A new class of potential prodrugs, 1,3‐cyclic propanyl phosphate esters of 18β‐glycyrrhetic acid, was designed and synthesized through the key reaction of 18β‐glycyrrhetic acid with 1,3‐cyclic propanyl phosphate ester catalysed by lithium diisopropylamide. The sustained‐release properties of 1,3‐cyclic propanyl phosphate esters of 18β‐glycyrrhetic acid in vivo were also investigated. The animal experiments showed that 18β‐glycyrrhetic acid was released from 1,3‐cyclic propanyl phosphate esters of 18β‐glycyrrhetic acid at a steady rate in rats and the plasma concentrations of 18β‐glycyrrhetic acid were nearly stable. The result indicated that 1,3‐cyclic propanyl phosphate esters of 18β‐glycyrrhetic acid have sustained‐release properties to avoid the quick metabolism of 18β‐glycyrrhetic acid. These prodrugs are highlighted as a promising new strategy to improve 18β‐glycyrrhetic acid metabolism.


INTRODUCTION With an estimated population of 140 million, Nigeria accounts for nearly one quarter of the populations of sub-saharan Africa. Growing at an estimated 2.8% a year, certainly it is one of the fastest growing populations in the World with children below the ages of sixteen for 45%. Despite its oil revenue, it is estimated that 70% of the population are still living below poverty line largely due to lack of access to quality education (VSO, 2008). The Federal Ministry of Education in its 2006 presentation identified education as a transformative tool to develop, empower and progress the Nigerian nation. Yet the education system which is regarded as an instrument for the nation's socio-economic development, industrial and technological advances and political as well as cultural growth, has over decades been in a state of severe crisis, stemming from an increase in disparity between the requirements vital to providing quality education and the available resources. According to the 2008 World Bank Report on Education sector ―Due to high increase in number and size, our education sector has now become large and complex, demanding for continuing strategic planning and efficient management‖. These challenges have prompted growing concern over the efficiency and effectiveness with which the nation's educational system is handled. In order to have a quality education that holds a strong bearing and insistence on economic empowerment of the Nigerian citizens, there is need to explore and examine the best options and best practices for guidance. Therefore, the primal intent of this presentation condenses around five major components viz: Brief Historical background of education in Nigeria; Theories of Quality Education; Toward constituting a Quality Education; Effective Entrepreneurship Education Programme; Entrepreneurship Education in the NPE, MS and Roadmap, Critique; Framing Challenges and Mapping Solutions.


Word version (with attachment) 2014-04-25 TO THE ADMINISTRATOR ADDRESSED: Subject: 2014 Summer School Program for Limited English Proficient (LEP) Students in Kindergarten and First Grade Attached is a copy of 19 Texas Administrative Code (TAC) Section 89.1250, Required Summer School Programs , w


We generalize the results of Randall and Sundrum to a wider class of four-dimensional space-times including the four-dimensional Schwarzschild background and de Sitter universe. We solve the equation for graviton propagation in a general four dimensional background and find an explicit solution for a zero mass bound state of the graviton. We find that this zero mass bound state is normalizable only if the cosmological constant is strictly zero, thereby providing a dynamical reason for the vanishing of cosmological constant within the context of this model. We also show that the results of Randall and Sundrum can be generalized without any modification to the Schwarzschild background.


The hydraulic valve block is a core component of an integrated hydraulic system. In practical usage, it exhibits problems such as material waste, long manufacturing cycle, significant energy loss, and leakage. Based on the aforementioned existing problems, this study presents the design of the hydraulic system valve block based on the valve block design principle. The internal valve channel of the hydraulic valve block is optimized for additive manufacturing technology to avoid auxiliary drilling, solve the problem of potential liquid leakage, and shorten the manufacturing cycle. Thus, it is more suitable for the production of customized complex hydraulic valve blocks. The multiobjective topology optimization method is applied to the lightweight design of the hydraulic valve block to save resources and decrease energy consumption. The results indicate that when compared with the original model, the minimum reduction rate of pressure loss in each oil circuit orifice after optimization of the hydraulic valve block corresponds to 32.02%, the maximum corresponds to 71.38%; the maximum stress of the final design corresponds to 542.9 MPa, which satisfies the material strength requirement; and the mass is decreased by 68.9%. Thus, the lightweight design of the hydraulic valve block is realized.


Abstract The reticular theory of twinning is extended to include the contribution of different, coexisting sublattices that consist of quasi-restored nodes (cooperative sublattices) and are characterized by a specific superposition index. The overall degree of quasi-restoration of the twin lattice is a function of the superposition index of the cooperative sublattices, and is expressed by a new parameter, called effective twin index, which is the generalization of the classical twin index. Twins where the effective twin index is lower than the classical twin index are termed hybrid twins. Several twins (e.g. twins of pyrite and of forsterite) that could not so far be explained by the reticular theory because of their too high twin index are interpreted as hybrid twins. The effect of hybrid twins on diffraction patterns is discussed.


In this overview of the development of the IBM 1401 and its underlying technologies, we begin with its vacuum tube forebears. We cover IBM's development of the 1401's basic enabling technologies and trace its origins in business accounting machines. We highlight its key features and characteristics, its market succession, and even its appearance in popular culture. We also describe the volunteer project at the computer history museum in Mountain View, California, that successfully restored two tape-oriented 1401 systems to full operation.


In this paper, we present an original solution for RF to DC conversion with multiple antennas. The presented device operates at 2.45 GHz. It combines passive parasitic element antennas (PEA) and RF to DC converters. The proposed device collects the RF energy with six independent antennas and realizes the conversion and summation of the DC voltage. The objective is to perform a uniform coverage of a room with a gain superior to a single and omnidirectional antenna. The typical application can be energy harvesting or command unit in home automation. This last application is our goal and the interest of the solution has been demonstrated through an application that aims at reducing standby mode consumption of electronic devices. The paper focuses on the attention required to realize an efficient summation. The whole system has been designed and manufactured to work in rooms from 3 to 15 meters side. The measured performances have validated this solution.


Based on S3C2440 processor and Linux3.6.6 kernel, wedeveloped an embedded impedance measurement system. This embedded system employ AD5933 as the impedance sensor, and data communication between AD5933 and S3C2440 processor is implemented with IIC communication protocol. In addition, the measurement resultsare displayed on the interface that is developed with QT.After modeling and solving the inverse problem by Newton Gauss algorithm, the distribution images of the object in the field are finally reconstructed satisfactorily. The research work offers a feasible and portable solution for clinical application of digital medical technology. Introduction Biomedical electrical impedance tomography (BEIT), as a newly noninvasive medical imaging technique, has been attracted much attentions in the field of biomedical engineering [1,2,3]. Compared to traditional imaging techniques, it has many advantages such as low cost, reusable, non-destructive, et al[4]. The BEIT technique which can monitoring the impedance variations between different tissues and organs, provides a new way to diagnose diseases [5,6,7,8]. Currently, the data acquisition module of most impedance measurement system are implemented with field-programmable gate array(FPGA)or digital signal processor(DSP)or PCI extensions for Instrumentation(PXI) and the collected experimental data is send to the computer with USB or serial port to reconstruct the images of the diseased tissue[9,10,11]. However, it quite inconvenient for moving these equipment when displaying the reconstructed images on computer monitors. It doesn't come near to the standard of current intellectualized medical instrument. In this regard, we in this paper develop aportable system that used for bioelectrical impedance measurement. Arm processor and Linux system are integrated into this embedded system. Impedance data are collected at the measuring end of this system, and the collected data are displayed with QT platform. This portable embedded based impedance measurement system integrate are more convenient and efficient when used for diagnosing diseases.


Objective To explore the relationship between the psychological bearing capacity and trait coping style of military chauffeurs, and explore their influencing factors. Methods By random cluster sampling, a total of 390 military drivers (experimental group) and 396 military non-drivers (control group) were chosen as subjects, and they were investigated with the Military Personnel Resilience Scale (MPRS) and Trait Coping Styles Questionnaire (TCSQ). The relationship between the psychological bearing capacity and trait coping style, and the influencing factors were analyzed. Descriptive statistics, independent sample t-test, correlation analysis and multiple stepwise regression analysis were performed by SPSS 17.0 software. Results  Compared to the control group, the scores of problem-solving, will power, self-confidence and the total score of MPRS were higher in experimental group (P<0.01 or 0.05). Correlation analysis suggested all the factors of MPRS in the drivers were positively correlated with positive coping style (P<0.01 or 0.05) and negatively correlated with negative coping style (P<0.01); the will power was positively correlated with educational level (P<0.05). Multiple stepwise regression analysis indicated that both the positive and negative coping style were incorporated into the regression equation with problem-solving, will power, interpersonal relationship, self-confidence and total score of MPRS as the dependent variables (P<0.01); negative coping style was incorporated into the regressive equation with family support as the dependent variables (P<0.01) and educational level was incorporated into the regressive equation with will power as the dependent variables (P<0.01). Conclusions The military drivers show a stronger psychological bearing capacity, and the major factor is trait coping style. In addition, educational level may affect the will power, so it may be regarded as a reference on psychological intervention to improve the psychological bearing capacity of military drivers.


Long before the Prime Minister's speech in Cardiff last October industry had been complaining that many school‐leavers applying for jobs could scarcely write their own language in a way that was either legible or even understandable, and could not do the simplest arithmetic. Was this the fault of the youngsters? Was the system that has as its aim equipping children to lead a full, fruitful, and useful life in some way to blame? Or were employers, universities, and technical colleges setting standards that were too high? Whatever the reasons the problem is there, is recognised, and is crying out for a solution.


Proposed interventions to prevent or delay the autoimmune response that leads to type 1 diabetes include reducing early exposure to complex antigens.


Olmesartan medoxomil is a selective angiotensin Ⅱ receptor subtype 1(AT1) antagonist that has been shown to reduce blood pressure. This paper reviews the pharmacological and toxicological research progress on olmesartan medoxomil.


Abstract: In this paper, we present a novel sensor-fusion method that reconstructs trajectory of mobile devices from MEMS inertial measurement unit (IMU). In trajectory reconstruction, the position estimation suffers seriously from the errors in the raw MEMS data, e.g. accelerometer signal, especially after its second-order integration over time. To eliminate the influence of the errors, a new error model is proposed for MEMS devices. The error model consists of two components, i.e. noise and bias, corresponding to different types of errors. For the noise component, a low-pass filter with down sampling is applied to reduce the inherent noise in the data. For the bias component, an algorithm is designed to detect the events of movement in a manner of sensor fusion. Then, the denoised data is further calibrated, according to different types of events to remove the bias. We apply our trajectory reconstruction method on a quadrotor drone with low-cost MEMS IMU devices, and experiments show the effectiveness of the method.


Objective To summary the experiment of primary pancreas kidney transplantation.Methods The combined pancreas kidney transplantation was performed on 5 patients with diabetes mellitus associated with diabetic nephropathy or renal function failure from Dec. 1998 to Jan. 2000. The trea ting experiences of the operation skills, prevention of rejection and the management of non technical complications were summarized.Results Acute rejection occurred in 2 cases on the 8 and 23 postoperative week respectively. Pure red cell aplasia occurred in 2 cases 2 weeks after operation. One case received the resection of pancreas due to thrombosis of pancreatic artery and 4 cases recovered satisfactorily after transplantation. They have healthily survived over 1 year.Conclusion Combined primary pancreas kidney transplantation is an effective treatment for insulin dependment diabetes mellitus patients associated with end stage renal failure or diabetic nephropathy.


Establishment of rural professional cooperative economic organization is the effective way to improve the competitiveness of agricultural products,is particularly important for such a big agricultural province of Heilongjiang.To this end,we must transform the grassroots leadership,better guidance services under actual,way of fostering professional cooperation economy organization;around scale,develop professional cooperative economic organization.


In this paper, a method to estimate the mechanical properties of GFRP, in which the fibers are dispersed randomly in the matrix, is proposed by applying the probabilistic technique. The analytical model used in this method is composed of n-layered elements, that are the unidirectionally reinforced mats. The principal axes of these elements are located in the composed model by using the random vectors. To examine the above mentioned technique, the estimations of Young's modulus, Poisson's ratio and tensile strength of the chopped strand mat GFRP are performed. The analytical result fairly coincides with the experimental one.


Objective To compare the clinical effects of conventional continuous mode phacoemulsification and burst mode cold phacoemulsification for cataract.Methods From March,2010 to September,2010,234 patients(234 eyes) with cataract in our hospital were selected as the objects.All the patients were randomly divided into experimental group(120 cases) and control group(114 cases),burst mode cold phacoemulsification and conventional continuous mode phacoemulsification were performed,respectively.The intraoperative emulsifying time of two groups were observed,the visual acuity and corneal endothelial cell density at postoperative 1 day and 1 week between two groups were compared,and the postoperative complications were also compared.Results The intraoperative emulsifying time in experimental group and control group were(17.1±5.2)s and(53.3±8.4)s,there was significant difference(P0.01).The proportion of patients with visual acuity equal to or more than 0.5 at postoperative 1 day and equal to or more than 0.8 at postoperative 1 week in experimental group were obviously higher than those in control group,there were statistical differences(all P0.05).There was no statistical difference in preoperative corneal endothelial cell density between two groups(P0.05).Compared with pre-operation,the postoperative corneal endothelial cell density at 1 day and 1 week of two groups were all decreased,there were statistical differences(all P0.05).The postoperative corneal endothelial cell density at 1 day and 1 week in experimental group were higher than those in control group,there were statistical differences(all P0.05).The complication incidence in experimental group was obviously lower than that in control group,there was statistical difference(P0.05).Conclusion Burst mode cold phacoemulsification is superior to conventional continuous mode in clinical effects,the intraoperative emulsifying time can be shortened significantly and the postoperative complications incidence is lower.


Abstract The aim of this study is to determine the availability of cloud-free images in relation to satellite revisit periods for the UK and in particular for the North West of England. Cloud cover was analysed with cloud masks from AVHRR/APOLLO and TERRA/MODIS cloud products. Availability of cloud-free images was determined from revisit frequency and the numbers of monthly images from Landsat ETM+, ASTER, Quickbird and SPOT satellite sensor series. The average number of cloud-free days at Risley Moss and Charter's Moss is five days per month with a minimum of one cloud-free day. The results show that satellite revisit periods and cloud cover are major determinants of satellite data availability and in this study it was also found that contrary to popular opinion, satellite overpass does not necessarily mean imaging opportunity and additional cloud-free images could be obtained when there are no satellite overpasses. The numbers of cloud-free images at a given site may be increased by combining data from ...


Human eye conjunctiva myiasis is caused by the infection of first larval of the flies. The main symptoms are eye itchand the sense of eyewinker, the larval visible in conjunctiva bursa. To do well the sanitation and banish the flies breeding place is theeffective way in controlling this disease.


The thermal properties of a novel family of xerogels prepared from diepoxy-terminated poly(ethylene glycol)sof approximate molecular weights 600, 1000, 2000 and 4000 Da and various aliphatic polyamines(ethylenediamine, 1,4-diaminobutane, hexamethylenediamine, 1,8-octanediamine, 1,10-decanediamine,1,12-dodecanediamine, diethylenetriamine, triethylenetetramine, tris(2-aminoethyl)amine) were studiedby DSC and TGA measurements in order to establish the influence of several structural parameters that mayaffect the physical state of the network-forming polymer at a certain temperature. All xerogels synthesizeddisplayed crystallinity which was affected by the MW of the PEG precursors, number of carbon atoms withinthe diamine chain, amine functionality and structure and amine/epoxy groups mole ratio. Both meltingtemperature and amount of crystalline phase were lower for networks with either shorter PEG chains,longer diamine chain, higher amine functionality and stoichiometric amine/epoxy groups ratio, while thethermal stability was higher for either longer PEGs, diamines with higher carbon atom numbers, higheramine functionality and stoichiometric amine/epoxy groups ratio.Keywords


On the basis of training schema analyzing of civil aviation flight crew both at home and abroad,this thesis puts forward the choice and educational innovation of civil aviation training schema in China in the new situation.


The preferred delivery for every pregnant woman is labor with minimal pain. Labor Pain is caused by the process of contraction of the uterus in an effort to remove the fruit of pregnancy. One technique without drugs or non-pharmacological that can be to provide comfort to the mother in the face of labor is massage. The purpose of this study was to determine the effectiveness of the Deep Back Massage and Endorphin Massage methods on the intensity of pain in the active phase I at BPM Setia. This research was conducted from July to August 2019 at BPM Setia. The population in this study were all women who gave birth normally with a gestational age of 37 to 40 weeks when I active phase in Setia BPM during the study period. The sample size is 30 respondents. The results obtained showed that the deep back massage and endorphin massage each showed a p-value α 0.05), which means that there is no difference in the effectiveness of the deep back massage and endorphin massage on labor pain in the active phase I at BPM Setia.


An analytical method for the computation of the axisymmetrical dynamic characteristics of partly-filled cylindrical tanks is presented. The liquid is assumed to be inviscid and incompressible. The tank shell is assumed to be of constant thickness and its material to be linearly elastic. Under these assumptions, two coupled partial differential equations govern the vibrations of the shell. Because the tank is partly-filled with liquid, two different solutions are obtained for the lower (wet) and upper (dry) portions of the shell. A system of linear homogeneous algebraic equations is obtained by satisfying the boundary conditions at the bottom and top of the tank and the compatibility equations at the junction of the wet and dry parts of the shell. The determinant of coefficients of this system leads to the frequency equation. The natural frequencies, mode shapes and stress distributions showed excellent agreement with those obtained from a numerical solution.


This paperdescribes a new methodoftesting metaloxidesurgearresters forHV applications. As inthe case of circuit-breaker testing, thisso-called synthetic methoduses two separate sources,namely a high-voltage source (precharged capacitors) anda high-current source (60-Hz network). Totheauthors' knowledge, thisisthefirst timethatthe synthetic testing ofsurgearresters hasbeenexperimentally demonstrated. Forthepurpose, a 25-kA(asymmetrical) short circuit was produced without theaidofa fusewireand maintained for0.2s(12cycles). Thistypeoftesting allows a tenfold increase inthepower-frequency (60-Hz) capacity ofa teststation. RoleofSacrificial Arresters


Coiled tubing drilling applications are becoming more widely used because of their major advantages over the conventional jointed pipe drilling methods. Some of the advantages are: – drilling and trip under pressure, – continous circulation while tripping, – slimhole and thru tubing capability, – small location footprint. Before using coiled tubing (CT) for drilling practice, serious engineering considerations have to be taken into account because of coiled tubing limitations such as: – small diameters, – limited reach in horizontal wells. – hydraulic limitations etc. Cuttings transport during drilling (either conventionally or with coiled tubing) has a major impact on the economics of the drilling process. Inefficient hole cleaning can lead to numerous problems such as stuck pipes, reduced weight on the bit and reduced rate of penetration, lost of circulation, additional costs because of adding additives in the drilling fluid, wasted time for wiper tripping etc. One of the major challenges still is how to achieve efficient cuttings transport in such wellbores because drillstring rotation during drilling is not possible. This limits mechanical agitation of cutting beds, so flow rates need to be increased to compensate for this. There are many studies which agreed that the major effective drilling parameter on cuttings trans-


Smartphones are extensively used for capturing real-time images. These images can be shared very easily through any network. Multiple images can be captured to make sure the information is properly photographed. Scale Invariant Feature Transform and its variants are extensively used in image retrieval applications. Still, image retrieval can be done effectively in certain circumstances involving intensity, position and orientation mismatch with the help of position, scale and orientation Scale Invariant Feature Transform, a powerful variant of Scale Invariant Feature Transform. In this paper, an efficient retrieval approach for mobile images using position, scale and orientation Scale Invariant Feature Transform algorithm is proposed. The main aim is to find relevant information by exploring the keypoints from a group of images than using one input image. The proposed method then mines similar images based on the saliency from a group of images and then calculates the key features for image retrieval. The precision achieved by the above algorithm is better in terms of retrieved images has been confirmed from the test results.


Pain palliation with bone-seeking radiopharmaceuticals is an effective treatment modality in patients with advanced metastatic bone cancer. Several studies have shown encouraging clinical results of palliative therapy using 186Re-HEDP, with an overall reported response rate of +/-71% for painful osseous metastasized prostate and breast cancer patients. 186Re-HEDP is a very potential isotope with numerous advantageous characteristics for this purpose. Myelosuppressive toxicity is limited and reversible, which makes repetitive treatment safe. However, individual studies are difficult to compare, and are hampered by the numerous and different methods used to assess clinical response. Standardized clinical response assessment using the objective multi-dimensional pain evaluation model should therefore be implemented.


As an Executing Layer between Plan Layer and Control Layer,MES may provide much more profit for industry.This paper concerns how to use Wonderware Intrack to design and implement MES for tracking the typical producing process.The MES's architecture,object and developing progress etc.are also described.


Objective To explore the expression of survivin gene in retinoblastoma (RB) and its relationship with the stages and histodifferentiation degree of RB and the expression of p53?bcl-2 proteins. Methods Expression of survivin, p53 and bcl-2 proteins in 38 RB conventional paraffin samples were detected with survivin, p53 and bcl-2 monoclonal antibodies respectively by immunohistochemical assay. The expression of survivin of normal retina in 6 control samples was observed. Results In 38 cases of RB, positive expression of survivin was found in 20 (52.6%); while none of the 6 normal retinal tissue expressed survivin, which had significant difference between the two group (P0.05). The positive expression of survivin did not correlate with sex of patient, disease stages and histological type (P0.05). In 38 RB cases, positive expression of p53 was in 25 with the rate of 65.8%, and of bcl-2 in 18 with the rate of 47.4%. The positive-expressed rates were much higher in positive-expressed p53 and bcl-2 group than those in the negative-expressed p53 and bcl-2 group (P0.05). Conclusion The increase of the expression of survivin implies that it may take part in the occurrence and development of RB; the interaction among survivin, p53 and bcl-2 may participate in the access and the course of RB.


A new series of pyrrole‐linked mono‐ and bis(1,3,4‐oxadiazole) hybrids, attached to various arene units, was prepared using a two‐step tandem protocol. Therefore, a benzohydrazide derivative was condensed with the appropriate aldehydes in ethanol at 80°C for 60–150 min to give the corresponding N‐(benzoylhydrazones). Without isolation, the previous intermediates underwent intramolecular oxidative cyclization in dimethyl sulfoxide at 180°C for 90–200 min in the presence of chloramine trihydrate to afford the target hybrids. The cytotoxicity of all hybrids was examined in vitro against the MCF‐7, HEPG2, and Caco2 cell lines. Arene‐linked hybrids 4i and 4j, attached to p‐nitro and p‐acetoxy units, were the most potent ones, with IC50 values ranging from 5.47 to 8.80 and 12.75 to 21.22 μM, respectively, when tested on the above cell lines. At the tested concentrations of 5 and 7.5 μM, hybrid 4i inhibited thymidylate synthase (TS) with the best inhibition percentages of 72.3 and 91.3, whereas hybrid 4j displayed comparable inhibitory activity to the reference pemetrexed. Hybrid 4j had inhibition percentages of 62.7 and 82.6, whereas pemetrexed had inhibition percentages of 59.2 and 80.2, respectively. The capability of hybrids 4i and 4j as potential TS inhibitors is supported by molecular docking studies, while SwissADME predicts their efficacy as drug‐like scaffolds.


AbstractBridge deterioration is inevitable in service, and the inspection and maintenance of bridges are needed to ensure structural integrity. To make cost-effective inspection plans, bridge manag...


Some of the features of the present case were very suspicious indeed of hysteria; the hemianasthesia, and the subsequent occurrence of anaesthesia on the right side, involving the whole of the cutaneous surface. So that, unless subsequent developments justified a different view, he thought it might be taken to be va case of hysteria in which vestibular reactions were absent. Dr. PRITCHARD said one would, a priori, conclude it to be a case of hysteria. He asked whether the retina was examined, and, if so, whether the field of vision was contracted, as that was said to be an accompaniment of hysteria. The PRESIDENT raised the question as to whether it might be organic ear trouble, with a neurosis which would account for the remainder of the symptoms. He did not regard spontaneous nystagmus as hysterical. Had any search and inquiry been made to ascertain whether there was congenital syphilis ? Mr. SYDNEY SCOTT said he considered that the case was not hysteria alone, but that there must be some organic lesion to account for the absence of vestibular reactions on one side. Dr. DAVIS replied that the case at first appeared to be one of acute suppurative labyrinthitis; but it could not have been that as the ear would not have dried up as it had done. Her vertigo was very violent, and two attempts made by the ophthalmic surgeon to examine her eyes were not very successful, as she became so giddy on opening her eyes that her fields of vision could not be taken. He did not think it could be pure hysteria, but that there must be some intracranial trouble as well. Wassermann's reaction proved negative. He did not think it was possible for a patient to be in such a condition unless there was something organic the matter with the nervous system. It had been suggested that she was insane, but that was not his (Dr. Davis's) view; her memory was good, and she knew that what she was doing was unreasonable. Mercury and iodide had no effect, but full doses of hydrobromic acid relieved the vertigo. Vertigo due to labyrinthine involvement was violent at first but tended slowly to pass off, whereas, vertigo due to an intracranial lesion persisted. This might be the case with hysteria, too.


Target ionization accompanied with projectile electron loss is investigated for 0.2–7 MeV Cq+ (q = 1 – 4) with He and 0.25–5 MeV Oq+ (q = 1 – 4) with He collisions. For projectile single-electron loss channel, the He double-to-single ionization ratio R is nearly independent of projectile charge state but dependent on the nuclear charge of projectile Zp. The results are analysed with atomic structure qualitatively. So far there have not existed the experimental data comparable with our results, to our knowledge. The ratio R is interpreted in terms of the two-step mechanism. This analysis agrees well with similar experiments in the literature.


Abstract Recent studies on no-reference image quality assessment (NR-IQA) methods usually learn to evaluate the image quality by regressing from human subjective scores of the training samples. This study presented an NR-IQA method based on the basic image visual parameters without using human scored image databases in learning. We demonstrated that these features comprised the most basic characteristics for constructing an image and influencing the visual quality of an image. In this paper, the definitions, computational method, and relationships among these visual metrics were described. We subsequently proposed a no-reference assessment function, which was referred to as a visual parameter measurement index (VPMI), based on the integration of these visual metrics to assess image quality. It is established that the maximum of VPMI corresponds to the best quality of the color image. We verified this method using the popular assessment database—image quality assessment database (LIVE), and the results indicated that the proposed method matched better with the subjective assessment of human vision. Compared with other image quality assessment models, it is highly competitive. VPMI has low computational complexity, which makes it promising to implement in real-time image assessment systems.


Although the various techniques used in ceramic production are obvious to those who work with clay professionally, they are not always recognized by archaeologists. A surface decoration commonly found on Greek and Roman fine wares, including Attic and Campanian Black Gloss, Thin-Walled Ware, Eastern Sigillata, Italian Sigillata, African Red Slip Ware, and Vesuvian Sigillata, is usually called rouletting, but I argue that in most cases the pattern is achieved by another technique known as chattering. Although some archaeologists are aware of the difference between the two procedures, there is ongoing confusion in the identification and use of these terms. This note discusses both decorative methods in an attempt to identify the diagnostic features that may help archaeologists differentiate between the two.


The identification of the level of anxiety, especially in accounting among business students, have not been directly explored and recognized. This empirical study was conducted to ascertain any significant determinants of accounting anxiety among business students. An online survey questionnaire was administered to all registered students at Bentley College, the largest business University in New England. A new accounting anxiety rating scale (AARS) was developed based on a modified computer anxiety rating scale (CARS) by Broome and Havelka (2002). A total of 1,112 responses were received and analyzed, indicating a response rate of 30 percent, which is relatively significant considering similar online survey responses. ANOVA tests were applied to determine the significance in accounting anxiety, controlling for four variables, academic majors, degree levels, experience and gender. The results show that there are significant differences in accounting anxiety levels in all four tests among students with different academic majors, degree levels, work experiences and significant difference in accounting anxiety between male and female students, contrary to recent and similar study of computer anxiety in business students.


The organizational and digital transformation projects are very complex to finalize, because of many reasons, and they mainly depend on the initial project's phases. The initial phases depend on the critical Building Blocks (BB) based Reorganizational Process' (RP) success, knowing that the Unbundling Process (UP) success and the deliverance of pool(s) of extracted and refined BBs, is the most important phase. BBs are combined to offer reusable Composite BBs (CBB), which are used to (re)build and optimize Organization's Units (OU) Platform (OUP). The optimization of OUs takes into account mainly intangible and non-financial objectives. The Enterprise's (ENT) RP is a sequence (or a set) of RPs on the OUP (RPOUP), which goal is to disassemble ENT's: Legacy OUs' archaic structure(s), Organizational processes, Information system's administration, Resources/Artefacts, Applications/Modules, Working models, and Components; into dynamic reusable CBBs which can be (re)used in standardized or In-House-Implemented (IHI) Organizational BBs (OBB); where a OU is a set of OBBs and different OUs can share OBBs, and hence CBBs. The conversion of the legacy OUs and their subsystems need an IHI Methodology, Domain, and Technology Common Artefacts Standard (MDTCAS) that maps to existing BBs, CBBs and OOBs. In generating Micro-Artifacts (MA) the RP can face major difficulties because of the ENT's heterogenous human profiles/cultures, system parts, OU's Resistances (OUR), managers/stakeholders exaggerated financial ambitions, and project's limited time/budgets. In this chapter the author uses an adapted version of the Applied Holistic Mathematical Model (AHMM) for CBB (AHMM4CBB) (Trad, & Kalpić, 2020a) to support RPOUP's feasibility that uses the initial phase's pool of BBs that result from the Automated Refine Processes (ARP) based UP.


The article recount nerve control and dissection of body about urinary function and nerve reflex mechanism of urinary function, and function recompose,recover,establishable reflex mechanism after spinal cord injury.


Biomarkers of oxidative stress malondialdehyde, catalase, reduced glutathione and plasma vitamin E were evaluated in pregnant, lactating and non pregnant non lactating Indian camels. Whole blood levels of malondialdehyde (lipid peroxidation product) were significantly higher in pregnant camels (28.11±0.44 nanomol/ml) than the non pregnant non lactating (25.86 ±0.91 nanomol/ml). Levels of catalase (antioxidant enzyme) and reduced glutathione (antioxidant protein) were also lower in pregnant and lactating camels than the non pregnant non lactating camels. Study showed that levels of oxidative stress biomarkers are higher in pregnant and lactating camels than the control non lactating non pregnant camels.


In this paper, the effects of wheel slip compensation in trajectory planning for mobile tractor-trailer robot applications are investigated. Firstly, a kinematic model of the proposed robot architecture is marked out, then an experimental campaign is done to identify if it is possible to kinematically compensate trajectories that otherwise would be subject to large lateral slip. Due to the close connection to the experimental data, the results shown are valid only for Epi.q, the prototype that is the main object of this manuscript. Nonetheless, the base concept can be usefully applied to any mobile robot subject to large lateral slip.


There are many references in the literature to the fact that the time taken for a vehicle to cross the stop-line at a signal-controlled road junction varies according to the type of vehicle and the manoeuvre it performs. Allowance for these effects has long been a common feature of standard procedures in various countries for making estimates of capacity and delay at signal-controlled road junctions. However, there has been relatively little discussion of exactly how these allowances should be applied. In this paper, one of the methods available is identified as being suitable for making these allowances. Another method which might seem to be suitable, is described and the errors which would result were it to be adopted are quantified. Full details are given of methods in which various combinations of estimates and raw data can be processed to give the quantities required for the estimation of capacity and delay. Some difficulties of data acquisition and processing are discussed and an approximate method is described which has much reduced requirements for raw data. (Author/TRRL)


This article addresses broad and plural concepts of landscape, considering its diversity of meanings and uses, which go far beyond its environmental and geographical connotations. It discusses the relationship between humanity and the rest of the natural world as a global process that combines physical and cultural aspects, and it seeks to highlight the contribution of environmental humanities to the understanding of these. Given the multiple conceptual interpretations and meanings of landscapes, we argue that current research trends are good examples of what we can consider as postdisciplinary approaches, challenging both disciplinary and interdisciplinary models of analysis. In this context, we use the recent pandemic scenarios as an example.


An object of the present invention is to provide a web service-based data backup and data archiving in a remote location. A client-side application is downloaded. The application client data encrypted locally and stored in the data storage facility at a remote location. Service provider and a data storage facility, can not access the information stored in the client. Encryption key used by the client, so that regain when the local computer has suffered damage, is stored in the data storage facility. Client encryption key, prevents the service provider or the like to access. Further, by performing a local indexing respect encrypted data, and remote locations already updates to data stored efficiently stored. .FIELD 5


As a recognized branch of medicine, anaesthetics is comparatively new. It was little over a century ago that the first anaesthetic drugs were used as an adjunct to surgery and it was not until the early years of the present century that the subject was included in the normal medical curriculum. The creation of the Diploma in Anaesthetics in 1935 was the first step towards its recognition as a specialty in its own right and this was followed by the establishment, in 1948, of the Faculty of Anaesthetists of the Royal College of Surgeons. The first professorial chair in anaesthesia was founded at Oxford in 1937. Some landmarks in the history of this important specialty are illustrated in the anaesthetic equipment shown on this month's cover, which provides a further example of the value of Mechanics in Medicine. In Ii99, Humphrey Davy stopped a tooth from aching by inhaling nitrous oxide and as a result of this experience suggested that the drug might be of value in relieving the pain of surgical operations. It was not until the mid-nineteenth century, however, that this suggestion was adopted, when Horace Wells, a dentist of Hartford, Connecticut, used it when treating his patients. At about the same time, also in America, Crawford Long, William Morton and Charles Jackson began using ether as an anaesthetic. On October 16th, 1846, William Morton, a dentist of Boston, Massachussetts, successfully anaesthetized a patient undergoing operation in the Massachussetts General Hospital. Morton's ether inhaler, consisting of a glass globe equipped with a mouthpiece and sea sponge soaked with ether, is illustrated on the cover. Also shown is an ether inhaler introduced in the following year by Dr. John Snow, an English physician who might well be called the first specialist anaesthetist. He invented a number of inhalers, paying great care not only to the physiological aspects, but also to the mechanical properties of the equipment. The inhaler illustrated basically comprised a draw-over ether container which was immersed in warm water. Dr. Snow described his ether inhaler in his book, published in 1847, entitled · On the Inhalation of the Vapour of Ether in Surgical Operations'. In 1876, Joseph Thomas Clover, FRCS, introduced a combined nitrous oxide ether apparatus. This could be used to administer either undiluted nitrous oxide oiether or a combination of both. The following year he introduced the portable regulating ether inhaler which is perhaps the best remembered of his inventions, although he himself preferred to use the nitrous oxide and ether apparatus of 1876. A predetermined quantity of ether was poured into the container and anaesthesia was achieved by the patient's breathing into and from the bag over the surface of the ether. The container was rotated to increase or decrease the anaesthetic potency of the inhaler. In 1847, Dr. James Young Simpson of Edinburgh began to experiment with chloroform in an attempt to prove that this could safely eliminate the agony of operation. Simpson succeeded, but not without much opposition, both from his medical colleagues and from sections of the public, until in 185!1 the use of chloroform was given the seal of respectability when Queen Victoria consented to its administration, by Dr. John Snow, during the birth of Prince Leopold and chloroform ' a Ia reine ' became the popular demand. During the late nineteenth and early twentieth centuries a number of medical committees reported on the respective merits of various anaesthetic agents. The Chloroform Committee of 1901, appointed by the British Medical Association, attempted to establish the minimum dosage of chloroform required to produce and maintain adequate anaesthesia. The Committee co-opted Mr. A. G. Vernon Harcourt, a physical chemist of Christ Church, Oxford, and their findings recommended an inhaler introduced by Harcourt in 190!1, which permitted a maximum administration of 2 per cent chloroform vapour in air with gradations downards when the temperature of the fluid was between 1!1°C and I5°C.


The interaction between multiple particles in an optical trap, and the phenomena collectively referred to as "optical binding", have been the subject of interest in a number of different trapping geometries. Examples include longitudinal and transverse trapping in counter-propagating Gaussian beams [1, 2], Bessel beams [3] and evanescent wave traps [4]. Excellent agreement has been demonstrated between experimental results and numerical simulation using electromagnetic theories such as Generalized Lorentz-Mie Theory or the Generalized Multipole Technique [5]. However there has been little success in translating these numerical simulation results into a simple, intuitive understanding of the differing mechanisms which produce these optical binding effects.


Pyrazoline derivatives, being used as potential medicinal agents, a series P 1 -P 5 containing 3,5-diphenylpyrazoline and N-phenyl-3,5-diphenylpyrazoline derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis (MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that P1 and P 2 possess good antibacterial potential against S. aureus, P 5 against S.epidermidis and P 1 and P 4 against E. coli.


The Papaveraceae family includes over 40 genera and 760 species in the world, of that 5 genera, namely Papaver L. with 15 species, Glaucium Mill with 5 species, Hypecoum L. with 3 species, Roemeria Medic with 2 species and Eschscholzia Cham with one cultivated species occur in Iraq. Opium alkaloids of 14 species of Papaveraceae in addition to two species of Fumaria L. were chemically studied using High Performance liquid Chromatography (HPLC) analysis. Five opium alkaloids, Morphine, Codeine, Thebaine, Papaverine and Noscapine were significantly detected and variably distributed in the species. The highest concentration of opium alkaloids was Noscapine with 814.624 ppm in P. somniferum while the lowest concentration was codeine with 66.978 ppm in the same species. Our results support maintaining Fumaria in distinct family Fumariaceae.


Abstract While the challenges of making a home in a foreign country are not unique to refugees in the Global South, their trajectories of integration in Southern host states often diverge from descriptions in the canonical literature on immigrant integration. What constitutes integration when newcomers share a language, cultural similarities, religious practices, and family ties with the receiving society? Drawing on ethnographic and interview data with Syrian refugees in Jordan, this article illustrates (a) the complexities that surface when refugees share similarities with members of the receiving community, (b) emerging axes of difference-making, and (c) distinct mechanisms linking humanitarian intervention with the facilitation and impediment of integration.


We study the sine‐Gordon soliton model of the dielectric α relaxation in crystalline polyethylene and similar polymers. These systems are characterized by a coupling constant which is essentially the ratio of intramolecular to intermolecular interaction strengths. We perform a stochastic molecular dynamics computer simulation for a wide range of coupling constants. We investigate analytically the high coupling (continuum) limit, modeled as free particle Brownian motion of the soliton, and the low coupling (pinned) limit, treated as hopping diffusion of the soliton over barriers at the sites on the polymer chain. We compare the simulation with these analytical theories and with experimental results for polyethylene. Agreement between simulation and theory for nonpolar polymers is excellent in the continuum limit down to relatively small coupling constants, and we also find quite reasonable agreement with experiments in that limit, considering the neglect of defects on the chains. The best fits of the pinne...


Objective: N-Nitroso-dibutyl amine (DBN) is an established hepatocarcinogen in rodents and its effects on the liver of Swiss albino mice have been examined. The observed alteration in marker enzymes activities indicates hepatic dysfunction and damage to the liver caused by DBN-treatment in mice. This study was aimed to check the carcinogenic effects of DBN exposure on liver mitochondria. Methods: DBN at a dosage of 10 mg kg -1 body weight in 5 % ethanol was administered intravenously weekly for a period of 16 w to induce cancer. Cancer induction was followed by monitoring the activities of marker enzymes such as acetylcholine esterase (AChE), glutathione-S-transferase (GST) and gamma-glutamyl transpeptidase (GGT), which was further supported by the histological examination of liver tissue. Transmission electron microscopy was done to see the alterations in the morphology of the liver mitochondria. Liver mitochondrial membrane proteins were isolated, and proteomic analysis was done. Results: Our preliminary observations indicated significant alterations in the activities of liver marker enzymes [GGT and AChE significantly elevated (<0.025 and<0.0001) whereas GST significantly decreased<0.0001] and in the morphology of liver mitochondria in mice upon DBN exposure. The shape and size of liver mitochondria were found to be highly disrupted and contained large vacuoles, enlarged cristae compartments in comparison to that of the normal control mice. The protein concentration was significantly elevated (<0.0001) in treated mice. The proteomic analysis of the liver mitochondrial membrane surface proteins showed differential expression in DBN-treated mouse compared to that of the normal control [d1]  . A protein of approximately 14 kDa was found to be overexpressed in the case of DBN treated mice which was seen in a trace amount in normal control. Overexpressed protein was found to be anionic in character. Conclusion: It was evident from the present study that a weekly dosage of DBN with 5 % ethanol for 16 w induces hepatocarcinoma in mice. These results suggested that alterations in the morphology of mitochondria, differential expression of mitochondrial proteins upon DBN exposure are associated with mitochondrial dysfunction in the liver. Keywords: N-Nitroso-dibutyl amine, Hepatocarcinogen, Carcinogenesis, Mitochondrial dysfunction


Reports on an evaluation of California suicide intervention training workshops to provide evidence that training is delivered with fidelity and adherence to the workshop's design, as well as with high quality.


Weed control and farming system practices are being assessed for their ability to reduce the seed banks of weed species that have developed herbicide resistance. In six long-term field experiments in southern Queensland, we are testing a wide variety of management practices to deplete soil seed banks of key annual weed species, such as wild oat, common sowthistle, liverseed grass, barnyard grass and awnless barnyard grass. Irrigation increased the emergence of all species with timing of irrigation being important. Higher stubble levels increased the emergence of larger seeded species including wild oat and awnless barnyard grass, but decreased the emergence of sowthistle. Cultivation reduced emergence of sowthistle and summer grasses, but had little effect on wild oat emergence. The wild oat seed bank was reduced by up to 70% in the top 5 cm of soil either with or without cultivation. However, cultivation increased the number of wild oat seeds persisting below 5 cm. Data suggest that wetter environments will encourage a more rapid depletion of summer grasses and sowthistle through increased emergence. Similarly, maintaining crop residue may increase seed bank depletion of larger seeded species through increased emergence. Cultivation increases the persistence of all the target species and is not a favoured practice for rapid depletion of the seed bank.


The device presented in this study is a four-probe, multi frequency, portable bioimpedance analyzer based on the magnitude-ratio and phase-difference detection principles. The system is built around a digital sine-wave generator, a voltage controlled current source, a phase-gain detector and a microcontroller unit. The Cole-Cole parameters, namely R0, R�,


We successfully realized phase‐locking of a 2.7‐THz metal‐metal waveguide quantum cascade laser (QCL) to a reference, which is generated from an external microwave signal by applying two stages of frequency multiplication. The reference is the 15th harmonic of a signal at 182 GHz, which is produced by a semiconductor superlattice nonlinear device. The signal at 182 GHz is generated by a multiplier‐chain (×12) from a microwave synthesizer at ∼15 GHz. Both QCL laser and reference radiations are coupled into a superconducting NbN hot electron bolometer mixer, resulting in a beat signal, which is fed into a phase‐lock loop. Spectral analysis of the beat signal confirms that the QCL is phase locked. This result is a crucial demonstration for a QCL used for local oscillator and opens the possibility to extend heterodyne interferometers into the far‐infrared range.


Thomas Carlyle remains a great name in the history of English letters, whose reputation has hardly ever been questioned in Britain, although it has been exposed in continental Europe and America. On reason for that may be that the United Kingdom has de facto remained unscathed politically by twentieth-century barbarism, for which this article argues that Carlyle bears a large share of responsibility in the history of ideas. Carlyle, remembered as a Romantic essayist par excellence in spite of his Goethean contempt for the Romantics, has also brought water to the mill of a tradition that views romanticism as a prelude to fascism. By revisiting Carlyle's philosophy, it is possible to show how, by a peculiar hybridization of the heritage of British Calvinism with German idealism, the "sage of Chelsea" has done much to herald and conjure up extreme-right totalitarianism in Europe, by his style as well as by his thoughts.


Essentials Fibrinogen circulates in human plasma as a complex mixture of heterogeneous molecular variants. We measured strain‐stiffening of recombinantly produced fibrinogen upon clotting. Factor XIII and molecular heterogeneity alter clot elasticity at the protofibril and fiber level. This highlights the hitherto unknown role of molecular composition in fibrin clot mechanics.


Texturing is a key technology in improving the reality of3D image,and texturing extensions are furthered texturing in SGI graphic stations.This paper discusses how to use de-tail texture extension,sharpened texture extension,etc.to improve3D scene quality in develop-ing Tower Control Simulators(TCS).


It is demonstrated that the accelerating and focusing phases of the nonlinear three‐dimensional axi‐symmetric laser wake can almost entirely overlap starting from a certain distance behind the laser pulse in homogeneous plasma. Such field structure results from the curvature of phase fronts due to the radially inhomogeneous relativistic plasma frequency shift. Consequently, the number of trapped low‐energy electrons can be much greater than that predicted by the linear wake theory. This effect is favorable for quasi‐monoenergetic acceleration of a considerable charge (several hundreds of pC) to about 1 GeV per electron in the plasma wakefield driven by an ultrashort (∼ 30 fs) weakly focused (r0 ∼ 100 μm) petawatt laser pulse.


The ability of different models to predict speeds of sound, u, of binary mixtures formed by alkoxyethanol and octane, oxaalkane or propylamine has been examined. The models applied are: the free length theory (LFT), the collision factor theory (CFT), and equations such as those proposed by Nomoto, Junjie or Van Dael. Collision factor theory, Nomoto's and Junjie's equations provide similar deviations between experimental and calculated u, which is represented quite accurately by these three models. Poorer predictions are obtained when applying the Junjie's equation to propylamine systems, probably due to the existence of strong interactions between unlike molecules in such mixtures. In contrast, slightly better u predictions from CFT are obtained for the systems 2-methoxyethanol + polyether, or hydroxyether + propylamine. The good u predictions obtained using Nomoto's equation remark the validity of Rao's assumption on additivity of molar sound velocity contributions from atoms, atom groups and chemical bonds of the constituent molecules. Discrepancies between experimental and calculated u are larger when using FLT than those obtained from CFT, Nomoto's or Junjie's equations. This has been ascribed to association and size or shape effects. The linear dependence on the molar fractions of the component liquids of the Rao's and Wada's constants suggests that there is no complex formation in the investigated mixtures, and that the interactions present in such systems are of dipolar type.


Conference Series LLc LTD is organizing "4th World Congress on Environmental Toxicology" which is going to be held in the month of October 26-27, 2020 at Osaka, Japan. The Theme of the conference is "An initiative to bring Harmony to the Natural Environment". The conference offers Prestigious Award for Young Research's at Environmental Congress 2020 Gathering the New-born Advances in Environmental.


AMALIA NAWANGSIH. Influence of Jigsaw Cooperative Learning Model with
Student's Learning Outcomes on Kewirausahaan Subject 11
 Grade with
Academic Year 2016/2017 in Bina Bangsa Mandiri Vocational High School.
Skription. Jakarta : Concentration of Accounting Education, Study Program of
Economic Education, State University of Jakarta. 2017.
The purpose of this study to determine the influence og jigsaw cooperative
learning model with student's learning outcomes on kewirausahaan subject 11

grade with academic year 2016/2017 in Bina Bangsa Mandiri vocational high
school. This study used a experimental method. In this study, experimental class
numbered 26 students and control class numbered 24 students. In experimental
class was given an action with jigsaw cooperative lerning model while control class
was given an action with problem based learning model. The instrument used for
students learning outcomes was an objective test to students.
The result of data analyst techniques as follows : all data are normal and
homogeneous. Result of hypothesis test using t-test obtained T count (2,59) > T
tabel (2,056).). therefore concluded that there is difference between learning
outcomes of students who used jigsaw cooperative learning model with learning
outcomes of students who used problem based learning model. Then this proves
that jigsaw cooperative learning model use has an effect on students learning
outcomes


Mapping algorithm which means which core should be linked to which router is one of the key issues in the design flow of network‐on‐chip. To achieve an application‐specific NoC design procedure that minimizes the communication cost and improves the fault tolerant property, first a heuristic mapping algorithm that produces a set of different mappings in a reasonable time is presented. This algorithm allows the designers to identify the set of most promising solutions in a large design space, which has low communication costs while yielding optimum communication costs in some cases. Another evaluated parameter, vulnerability index, is then considered as a principle of estimating the fault‐tolerance property in all produced mappings. Finally, in order to yield a mapping which considers trade‐offs between these two parameters, a linear function is defined and introduced. It is also observed that more flexibility to prioritize solutions within the design space is possible by adjusting a set of if‐then rules in...


Varieties of genotypes frequency in populations of mating of homologous genotypes or mating of homologous phenotypes were studied in this paper, demonstrates consistence and difference of their genotypes entropy and gametes' mutual information. The conclusions were tested by computer imitation.


By means of the theory of time scales and Riccati transformation technique,we establish some new oscillation criteria for the second-order nonlinear neutral delay dynamic equations on time scales.Our result generalizes and improves some known results for the oscillation of second-order nonlinear delay dynamic equations on time scales.


In this article we present some techniques to determine the types of automorphisms of extremal doubly even binary self-dual codes, also called ex- tremal type II codes, with parameters (24,12,8), (48,24,12) and (120,60,24). We aim to obtain information about the automorphism group considering the exclusion of some prime numbers from its order. Keywords: Binary codes, self-dual codes, doubly even codes, extremal codes and automorphisms of codes. MSC2010: 11T71, 20B25, 94B60.


Description The structures, properties, and calcium signaling roles of two proteins implicated in Wolfram syndrome are discussed. Mutations in WFS1 (which encodes Wolframin, WFS1) and CISD2 (which encodes CDGSH iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts with juvenile diabetes and progresses to neurological dysfunction. WFS1 and CISD2 belong to different protein families with distinct properties. Despite differences between WFS1 and CISD2, loss-of-function mutations in these proteins result in similar disease phenotypes, suggesting that they have convergent roles. WFS1 and CISD2 both localize at the endoplasmic reticulum (ER), the main intracellular calcium (Ca2+) store, which is implicated in several diseases, including WS. Here, we not only review the roles of WFS1 and CISD2 in Ca2+ signaling modulation but also point out knowledge gaps. Because WFS1 and CISD2 form complexes with Ca2+ transporters and Ca2+ channels, it is thought that they influence the activity of these transport systems in cells. Together, the studies reviewed here provide a better understanding of the pathogenesis and the severe disease burden of WS and may contribute to the development of therapeutics.


Catholic modernism, an intellectual trend that developed within the Catholic Church in the late nineteenth and early twentieth century, sought to rebuild the Church and to modernise its teaching methods. It combined tradition and modernity, and it was at the level of literature that such link was made – a medium whose effect on religious belief was significant. Due to its reformist tendencies modernism was often called "the new Protestantism." St. Francis was also the patron of the quest for renewal. A resurgence of interest in the saint was noted in the late nineteenth and early twentieth century among Anglicans, Lutherans, and Protestants. St. Francis represented such qualities that all Christians, regardless of denomination, see as a perfect incarnation of the principles of the Gospel. Protestants (followed by Catholic modernists) portrayed him as a reformer of the thirteenth-century Church and a patron of the "new reformation." In a natural way, he combined and renewed, or actually restored the teaching of Christ. In the Young Poland era, the approach to St. Francis was largely shaped by the book Life of St. Francis of Assisi by Paul Sabatier. Traces of its reception can be found in most Catholic publications of the period devoted to the life and work of the saint.


Comparing molecular structures isoften donebased onrelatively high-dimensional, binary fingerprints thatrepresent absence orpresence ofcertain structural elements. Thethen commonly usedTanimoto distance considers allthose bits similar, although someoftheunderlying structural elements maybequite closely related. We propose aweighting schemeforsuchrelated bits whichsoftens theinfluence ofdifferences inbitpatterns that represent similar contexts. We demonstrate theusefulness ofthis context awaresimilarity metric using anautomated bit-weighting mechanism anda setofsimilarity weights basedonTopomer shapesimilarity between thestructural elements encoded inthe finger print.


Structurally different ferrocene peptides I–VI exhibit considerable conformational differences. This study has explored the structural properties of VII [Y-AA-Fca-OMe ; Y = di-tert-butyl dicarbonate (Boc), acetyl (Ac) ; AA = L-Ala, DAla ; Fca = 1-aminoferrocene-1-carboxylic acid] with an exchanged sequence of constituent amino acids relative to VI (Y-Fca-AA-OMe ; Y = Boc, Ac ; AA = L-Ala, D-Ala). The ferrocene peptides VII were obtained by coupling C-protected Fca with Boc-L-Ala-OH and Boc-D-Ala-OH, respectively. The Boc protecting groups of the obtained conjugates Boc-AAFca-OMe (2a, AA = L-Ala ; 2b, AA = D-Ala) were convertedto sterically less demanding Ac groups to give Ac-AA-Fca-OMe (3a, AA = L-Ala ; 3b, AA = D-Ala). In order to examine their conformational properties, peptides VII were subjectedto spectroscopic analysis (IR, 1H NMR, CD) and molecular modeling (DFT). The alteration of peptides VI into VII significantly influenced their conformational properties. Conjugates VI were stabilized through interchain hydrogen bonding, whereas inter- and intrachain hydrogen bonds were established in their constitutional isomers VII. The replacement of the bulky Boc group with an Ac group did not cause major conformational changes, and the absolute configuration of the alanine chiral centers did not affect the conformational properties.


We discuss the phenomenological consequences of the UA(1) symmetry-breaking two-flavour four-fermion antisymmetric (AS) Lorentz tensor interaction Lagrangians. We use the recently developed methods that respect the `duality' symmetry of this interaction. Starting from the Fierz transform of the two-flavour 't Hooft interaction (a four-fermion Lagrangian with AS tensor interaction terms augmented by Nambu and Jona-Lasinio (NJL)-type Lorentz scalar interaction responsible for dynamical symmetry breaking and quark mass generation), we find the following. (a) Four antisymmetric tensor and four AS pseudotensor bosons exist which satisfy a mass relation previously derived for scalar and pseudoscalar mesons from the 't Hooft interaction. (b) Antisymmetric tensor bosons mix with vector bosons via one-fermion-loop effective couplings so that both kinds of bosons have their masses shifted and the fermions (quarks) acquire anomalous magnetic moment form factors that explicitly violate chiral symmetry. (c) The mixing of massive AS tensor fields with vector fields leads to two sets of spin-1 states. The second set of spin-1 mesons is heavy and has not been observed. Moreover, at least one member of this second set is tachyonic, under standard assumptions about the source and strength of the AS tensor interaction. The tachyonic state also shows up as a pole in the space-like region of the electromagnetic form factors. (d) The mixing of axial-vector fields with antisymmetric tensor bosons is proportional to the (small) isospin-breaking up-down quark mass difference, so the mixing-induced mass shift is negligible. (e) The AS tensor version of the Veneziano-Witten UA(1) symmetry-breaking interaction does not lead to tachyons, or any AS tensor field propagation to leading order in NC.


Abstract The problem of inducing convergent quasi-sliding regimes on smooth state-space surfaces of non-linear single-input single output discrete-time controlled systems is addressed in full generality. A suitable extension of the notion of relative degree is used in establishing the most salient features of quasi-sliding motions in non-linearly controlled systems. Several examples are given.


Abstract Let A be a commutative ring with identity and the ring of formal power series in n variables. In this paper, we consider the SFT-property on A and its relation with . Then, we see when the minimal prime ideals of are extended from those of A. We discuss the notion of nicely-contractible ideals in and its relation with the SFT-property. We apply our results to the ideals and the ideals of .


This article deals with the development of a rigorous solution to the steady-state temperature in an anisotropic strip. The solution is given with respect to a coordinate system (x, y), which conforms with the strip geometry but does not necessarily coincide with the principal directions of the anisotropic material. Using a partitioning-matching technique and the separation of variables method, exact expressions are obtained for temperatures in the strip under prescribed boundary temperature conditions. Numerical values of the temperatures and heat flux are provided in graphic form. Also, a discussion is presented regarding the solution method and the temperature distribution features in the heat conduction problem of an anisotropic medium.


Shape variation characteristics of the Brillouin gain spectrum caused by sinusoidal-like strain distribution, which is a typical non-uniform strain distribution produced in a ring structure, are clarified through numerical calculation and experiments.


Objectives. To evaluate the proportion of women with threatened miscarriage (TM) who proceed to miscarriage in a population of single ethnicity and to investigate prospectively their risk of adverse pregnancy outcome in relationship with the cytokines levels in their circulation. Methods. We conducted a prospective observational study over a period of 1 year of 94 Maltese women presenting with TM at the same hospital and compared their clinical data with those of 564 age-matched controls from the National Obstetric Information System (NOIS) of Malta. Main outcome measures included gestational age and weight at delivery and incidence of adverse pregnancy outcomes. A pilot study was carried out, where in subgroups of 10 women with TM (n = 10), non-pregnant women (n = 12), normal pregnant controls (n = 9) and women presenting with missed-miscarriage (n = 11), the plasma levels of β-human chorionic gonadotrophin (β-hCG), tumour necrosis factor α (TNFα), interferon γ (IFNγ), interleukin-6 (IL-6), interleukin-10 (IL-10) and TNF-receptors 1 (R1) and 2 (R2) were measured. Results. Of the women presenting with TM, 25 (26.6%) proceeded to complete miscarriage. The TM group had also a significantly higher incidence of antepartum haemorrhage (p < 0.005), pre-eclampsia (p < 0.05), foetal growth restriction (p < 0.05), premature labour (p < 0.001) and retained placenta (p < 0.005). In the pilot biochemical analysis, significantly (p < 0.05) higher levels of TNFα and lower levels of TNFR2 were found in the TM subgroup compared to non-pregnant controls. The ratio TNFα/IL-10 was significantly (p < 0.05) higher and the β-hCG levels was significantly lower (p < 0.01) in missed-miscarriage and non-pregnant subgroups than in TM and normal pregnant controls. The IFNγ/1L-10 and IFNγ/1L-6 ratio were significantly (<0.001) different between the four subgroups with the lowest level found in TM. No similar gradient was found for the TNFα/1L-6 ratio. Conclusion. Women presenting with TM are at significantly increased risk of adverse pregnancy outcome and the pathophysiology of these conditions involves a change in the Th1/Th2 balance. Changes in levels of cytokines could help to predict and thus prevent the development of some of these complications.


A 67‐year‐old man was admitted with a 2‐year history of dropped head. Neurological examination revealed ptosis, dysarthria, neck weakness, hyporeflexia of all limbs, and autonomic failure. Electrophysiologic study showed a 400% increment response to high‐rate repetitive nerve stimulation. Serum anti‐P/Q‐voltage‐gated calcium channel antibody was positive, confirming the diagnosis of Lambert–Eaton myasthenic syndrome (LEMS). His symptoms and electrophysiological abnormalities improved with oral prednisolone following plasmapheresis. This is the first report of LEMS as a cause of dropped head syndrome. Muscle Nerve 40: 134–136, 2009


This paper presented by McCarty and Harriet Taylor at the June 1946 Cold Spring Harbor Symposium was largely written by McCarty
 and was part of his effort to bring his work on transformation to "some kind of reasonable conclusion" prior to his
 leaving the lab that July. By the time this paper was published, McCarty recognized that his push for closure caused him to
 reach certain conclusions and include some data that would soon be proved erroneous by subsequent experiments by Rollin Hotchkiss,
 also in Avery's lab.


In the present study, surface protection properties of multiwall carbon nanotubes (CNTs) deposited on polished austenitic stainless steel are evaluated. Electrophoretic deposition is used as a coating technique. Contact angle measurements reveal hydrophilic as well as hydrophobic wetting characteristics of the carbon nanotube coating depending on the additive used for the deposition. Tribological properties of carbon nanotube coatings on steel substrate are determined with a ball-on-disc tribometer. Effective lubrication can be achieved by adding magnesium nitrate as an additive due to the formation of a holding layer detaining CNTs in the contact area. Furthermore, wear track analysis reveals minimal wear on the coated substrate as well as carbon residues providing lubrication. Energy dispersive x-ray spectroscopy is used to qualitatively analyse the elemental composition of the coating and the underlying substrate. The results explain the observed wetting characteristics of each coating. Finally, merely minimal oxidation is detected on the CNT-coated substrate as opposed to the uncoated sample.


The paper reports determinations of rate constants for the physical deactivation of 0 2(1Ag) by gases present in the atmosphere. A modified discharge-flow technique was employed, and relative concentrations of 0 2(1Ag) were measured by a photoionization method. The rate constants for the process were ^ 1.1 x 10"19, =s£ 2.1 x 10"19, ~2.4 x 10-18, ~3.9 x 10~18, ~ 1.5 x 10"17 (cm3molecule^s-1) for M = N2, Ar, 0 2, C02, HsO respectively. The rate constant for quenching by dry air was measured directly to be 4.3 ± 0.7 x 10~19 cm3 molecule-1 s-1; this value is consistent with the most recent estimate based on [02(1Ag)] in the upper atmosphere (3.5 +1.0 x 10-19 cm3 molecule-1 s-1; W. F. J. Evans, private communication). Wall deactivation efficiencies varied from 1.2 x 10-5 to 2.3 x 10-5.


In order to clarify the response of crops to sink restriction, we examined the effects of ear removal on photosynthesis of the flag leaf in wheat. For 11 days there was no difference in CO2 exchange rates between the control and the no-ear plants after ear removal, but after 11 days the rates in the no-ear plants were higher. For 11 days there was no difference in diffusive conductance, apparent quantum yield (AQY) and apparent carboxylation efficiency (ACE) and chlorophyll contents between the plants. Though there was no difference in diffusive conductance, AQY and chlorophyll contents between the plants after 11 days, ACE and ribulose-1, 5-bisphosphate carboxylase/oxygenase contents in the no-ear plants were higher than those in the control. Therefore, it was presumed that activity of CO2 fixation system in the no-ear plants was higher and that flag leaf senescence was delayed due to ear removal.


The gear transmission is most widely used in mechanical transmission with large carrying capacity,high efficiency,precise gear ratio,compact structure,reliable operation and long life.However,the gear transmission design process needs a large number of complex charts and calculations,which causes great difficulty for designers.This article fits the charts and statics in the process of design to make them programmed,and then uses VB language to input the data that needed directly into the computer system,which provides several schemes to be selected for designers.


Given a regular weight $\omega$ and a positive Borel measure $\mu$ on the unit disc $\mathbb{D}$, the Toeplitz operator associated with $\mu$ is
$$
\mathcal{T}_\mu(f)(z)=\int_{\mathbb{D}} f(\zeta)\bar{B_z^\omega(\zeta)}\,d\mu(\zeta),
$$ where $B^\omega_{z}$ are the reproducing kernels of the weighted Bergman space $A^2_\omega$. We describe bounded and compact Toeplitz operators $\mathcal{T}_\mu:A^p_\omega\to A^q_\omega$, $1<q,p<\infty$, in terms of Carleson measures and the Berezin transform
$$
\widetilde{\mathcal{T}_\mu}(z)=\frac{\langle\mathcal{T}_\mu(B^\omega_{z}), B^\omega_{z} \rangle_{A^2_\omega}}{\|B_z^\omega\|^2_{A^2_\omega}}.
$$ We also characterize Schatten class Toeplitz operators in terms of the Berezin transform and apply this result to study Schatten class composition operators.


Background: Asthma is a heterogeneous disease characterized by inflammation occurring with traits similar to those of respiratory history such as wheezing, shortness of breath, chest contents, and a cough that causes the disorder.
Purpose: To know the benefits of breathing control and diaphragmatic breathing in reducing shortness of breath in people with asthma as well as to Know the benefits of static bicycle in improving functional ability in asthmatics.
Result: After 6 weeks of therapy, there was a decrease in the degree of shortness of breath, where the assessment of shortness of breath on T5 and T6 which previously had a value of 3 to the value 1, while the evaluation using Six-Minutes Walking Test increased, where in the first meeting get 26 , 4 which belong to the POOR category and at the last meeting get the value of 27.2 which belongs to FAIR category.
Conclusion: breathing control and diaphragmatic breathing can reduce the degree of shortness of breath and static bicycle can improve functional ability.
Keywords: asthma, breathing control, diaphragmatic breathing, and static bicycle


We report transport studies of GaSb/InAs core/shell nanowires. It is shown that with increasing InAs shell thickness, it is possible to tune the carrier concentrations and transport in the structures from p-type (core-dominated) to n-type (shell dominated). For nanowires with an intermediate shell thickness (5–7 nm), we show that the transport is ambipolar, such that an applied top-gate potential can provide further control of carrier type and transport path. In this range, the nature of the GaSb-InAs junction also changes from broken gap (semimetal) to staggered (narrow bandgap) with a small decrease in shell thickness. From a device point of view, we demonstrate that the presence of a thin (<3 nm) InAs shell improves p-type GaSb nanowire transistor characteristics.


In data mining process,it only considers the weight of data items,or only considers the temporal semantics of data,resulting in incomplete mining results.For the above-mentioned problem,the weighted association rules,temporal association rules and the periodicity of temporal data are studied.The weights,K-support bounds and periodicity are introduced into temporal association rules.The algorithm of mining weighted temporal association rules based on periodicity is proposed.Applying the algorithm in audit data of a management system,results show that this algorithm can accurately mine the weighted temporal association rules,and with the same time complexity,it makes the mining of association rules more meticulousness than weighted association rule algorithm.


Cu-MCM-41 nano particles have been shown to effectively catalyze the multi-component synthesis of propargylamines by the reaction of aldehydes, amines, and alkynes (A3 coupling) effectively at 100 °C under solvent-free conditions. Spherical Cu-MCM-41 nanoparticles were prepared by a simple method and characterized by XRD, TEM, SEM and FT-IR techniques. Cu-MCM-41 with a Si : Cu molar ratio of 20 : 1 shows the best catalytic activity. The catalyst was recovered by simple filtration and reused for several cycles without considerable loss of activity.


Has analyzed the FIR digit filter's basic principle,designs the FIR low pass filter under the MATLAB environment using the window box number,has realized the low pass FIR filter's design simulation.It will design conforms to the request filter to real-ize on TI Corporation DSP TMS320LF2407A,through the experimental result indicated that the FIR filter accuracy is high,the stabil-ity is good,may the effective filtration unwanted signal,the design result satisfy the performance index request.


Baxter, William H. III 1992. A Handbook of old Chinese phonology. Trends in Linguistics Studies and Monographs 64. Berlin: Mouton de Gruyter. Sagart Laurent 1999. The Roots of Old Chinese. Amsterdam: Benjamins Pulleyblank, E.G. 1962. 'The consonantal system of Old Chinese', Asia Major, 9: 58-114, 206-65 Pulleyblank, E.G. 1984. Middle Chinese: A Study in Historical Phonology, Vancouver: University of Bristish Columbia Press. 郑张尚芳 2003.〈上古音系〉,上海教育出版社


Currently, consumers purchase sporting goods not only to satisfy their requirements according to their benefits, but also for their own pleasure and satisfaction. Using Moderation of Price Perception and Instagram Promotion, the purpose of this study is to examine and analyze the impact of hedonistic and utilitarian values on the purchasing motivations of sports fans. As a test of research data, 301 respondents were selected using a technique of purposive sampling and the criteria of individuals who like sports and are familiar with the brand Duraking. The data was analyzed using Structural Equation Model Partial Least Square (SEMSmartPLS) version 3.2.9. According to the findings of the study, hedonistic values have a direct effect on purchase intention, whereas utilitarian values do not. Price Perception and Instagram Promotion strengthen the influence of Hedonic Value and Utilitarian value on purchase Intention by acting as moderators.


In 1992, a multiagency model of transition planning was developed and implemented to meet the identified needs of students who are deaf-blind in Michigan. This article outlines the project's activities, accomplishments, challenges, and goals for the future.


An oil pressure tank is the energy conservator of the governor.The oil pressure tank of GEDEPID 1 500 governor has broken down many times in recent years in Wanjiazhai Hydraulic Power Station.To cut back the fault rate and ensure safe and steady operation of the generating unit,the author analyses the tank's sturcture and working principles,classifies the various breadowns,searches for the causes and puts forward corresponding countermeasures in combination with concrete experiences.After the improvement,the similar faults have been avoided,which shows that the improvement is reasonable and effective and has some reference value for the maintenance of this sore of apparatus.


Negotiation between virtual agents and humans is a complex field that requires designers of systems to be aware not only of the efficient solutions to a given game, but also the mechanisms by which humans create value over multiple negotiations. One way of considering the agent's impact beyond a single negotiation session is by considering the use of external "ledgers" across multiple sessions. We present results that describe the effects of favor exchange on negotiation outcomes, fairness, and trust for two distinct cross-cultural populations, and illustrate the ramifications of their similarities and differences on virtual agent design.


Nowadays, micro-blogging sites are getting popular due to the involvement of a large number of users. In the case of natural disasters, a significant amount of relevant information (giving crucial information) are present amongst the tweets. Therefore, there is a need to develop a system that summarizes relevant tweets by extracting informative tweets. In the current paper, we have proposed an unsupervised approach for summarizing the relevant tweets namely, MOOTweetSumm+, which automatically selects the informative tweets. Several tweet-scoring measures: (a) anti-redundancy measuring the dissimilarity between tweets; (b) similarity with outputs provided by LexRank (a graph-based method measuring tweet importance based on the concept of eigen-vector centrality in a graph); (c) BM25 based ranking function; (d) tf-idf based ranking function; (e) length of the tweet; (f) re-tweet count, are simultaneously optimized utilizing a binary differential evolution algorithm. Further, two different versions of the LexRank, utilizing syntactic and semantic similarity, have also been explored. For evaluation, four different disaster-event related datasets are used, and performance is measured in terms of ROUGE scores. An ablation study is also performed to determine which set of measures is best suited for different datasets. From the results obtained, it is clearly evident that our approach improves by 13.2% and 5.8% in terms of ROUGE-2 and ROUGE-L scores, over the existing approaches, respectively.


Recently, the Poti river mouth region has experienced environmental impacts that resulted in a change of landscape in its dry season, highlighting the eutrophication and proliferation of phytoplankton, algae, cyanobacteria and aquatic plants. Considering the aspects related to water-quality monitoring in the semiarid region of Brazil from remote sensing, this study aimed to evaluate the performance of Sentinel-2A satellite data in the retrieval of chlorophyll-a concentration in Poti River in Teresina, Piaui, Brazil. The chlorophyll-a concentration retrieval and mapping methodology involved the study of the water surface reflectance in Sentinel-2A images and their correlation with the chlorophyll-a data collected in situ during the years 2016 and 2017. The results generated by the Chl-1, Ha et al. (2017), Chl-2, Page et al. (2018), and Chl-3, Kuhn et al. (2019) equations show the need for calibrating the algorithms used for the Poti River water components. However, the empirical algorithm Chl-2 shows a correlation has been established to identify the spatiotemporal variation of chlorophyll-a concentration along the Poti River broadly and not punctually. The spatial distribution of this pigment in maps derived from Sentinel-2A is consistent with the pattern of occurrence determined by the in situ data. Therefore, the MSI sensor proved to be a tool suitable for the retrieval and monitoring of chlorophyll-a concentration along the Poti River.


....................................................................................... i LIST OF FIGURES .......................................................................... iv LIST OF ABBREVIATIONS ............................................................ v INTRODUCTION ........................................................................ 1 MATERIALS AND METHODS .................................................. 8 RESULTS ................................................................................... 13 DISCUSSION ............................................................................. 37 REFERENCES ............................................................................ 41 ABSTRACT IN KOREAN ......................................................... 45 -IN KOREAN ......................................................... 45 -


Development Credit Agreement-Port Modernization Project II (with schedules and General Conditions Applicable to Development Credit Agreements dated 1 January 1985). Signed at Washington on 7 May 1990


We investigate the role of NO2 in dimethyl ether (DME) ignition with a combustion shock tube. Ignition delay times are measured at 987–1517 K and 4 and 10 atm. Different equivalence ratios (0.5, 1.0, and 2.0) and NO2 and DME concentrations are explored. NO2 promotes DME ignition, and the promoting effect becomes more pronounced at high NO2 concentrations or low temperatures. NO2 addition also augments the influence of the equivalence ratio on ignition delay times. Four detailed reaction mechanisms from the literature are examined against the measurements, and an updated kinetic model is proposed and validated in comparison to experiments. On the basis of the updated model, sensitivity analysis, reaction flux analysis, and rate of production analysis are conducted to provide details on the kinetic effect of NO2 on DME ignition.


Traditional medicines are used by about 60% of the world's population. It has prompted man to explore his immediate natural
surroundings and try many plants to develop a variety of therapeutic agents. The herbal drug market itself is growing at a rate of 20-30%
annually. The growth rate of this in the global market is encouraging for the manufacturers to produce more pure herbal drugs. Bryonopsis
laciniosa Linn is one such herbal plant which has many therapeutic actions. It is most commonly available plant throughout India. Traditionally it
is used as Antipyretic, Analgesic, Anti-inflammatory, Anti-microbial. As per literature, there is no extensive work done on Pharmacognostic and
Phyto-chemical screening of the plant so, it was planned for this study.


The activity of the enzymes 5′-nucleotidase (EC 188.8.131.52), adenosine nucleosidase (EC 188.8.131.52), adenine phosphoribosyl transferase (EC 220.127.116.11) and acid phosphatase (EC 188.8.131.52) was determined in sections of tomato plant (Lycopersicon esculentum Mill. cv. Bellina). The distribution of the enzymes changed markedly during development and a role for these enzymes in cytokinin metabolism is suggested.


The present invention discloses a macrolide compound or salt thereof, synthesis method, pharmaceutical composition, and application thereof. The present invention provides a method for preparing a macrolide compound 1, a macrolide compound 1', or a salt thereof; also provided are a macrolide compound 2, macrolide compound 2', or salt thereof, a pharmaceutical composition containing said compound or salt, and the application thereof in the preparation of a pharmaceutical for inhibiting methicillin-resistant Staphylococcus aureus. When one or more of the macrolide compound 2, the macrolide compound 2', the macrolide compound 2 salt, and the macrolide compound 2' salt of the present invention is used together with a β-lactam antibiotic, the inhibiting effect of the β-lactam antibiotic on methicillin-resistant Staphylococcus aureus is significantly increased. This is a new class of potentiator having a good potentiating effect in vitro, alleviating methicillin-resistant Staphylococcus aureus resistance to β-lactam antibiotics, and having good prospects for market development.


Objective: Investigate safety, tolerability, pharmacokinetics (PK), and target engagement (TE) of losmapimod in healthy volunteers (HV) and FSHD1 patients. Background: FSHD is caused by the aberrant expression of the homeobox transcription factor DUX4 in skeletal muscle. DUX4 activates a transcriptional program resulting in muscle loss and disability. Losmapimod is a selective small molecule inhibitor of p38α/β being developed to reduce DUX4 expression, the root cause of FSHD. Design/Methods: This was a three-part study. Part A: 10 HV randomized to single oral doses of losmapimod (7.5 mg then 15 mg; n=8) or placebo (both dosing periods; n=2). Part B: Parallel-group study of losmapimod15 FSHD1 patients randomized to placebo (n=3), losmapimod 7.5 mg (n=6) or 15 mg (n=6) twice daily for 14 days. Part C: Open-label losmapimod 15 mg (n=5) twice daily for 14 days. Muscle biopsies were performed at baseline and during treatment, targeting MRI normal appearing (Part B) and STIR + (Part C) muscle tissue. PK and TE, measured by phosphorylated and total HSP27, were assessed in blood and muscle. Results: Preliminary blinded analysis showed that adverse events (AE) were mild and self-limited. PK profiles were similar between HV and FSHD patients: mean Cmax in blood of 36.6 (HV) and 40.9 ng/mL (FSHD) for 7.5 mg, and 74.6 ng/mL (HV) and 85.0 ng/mL (FSHD1) for 15 mg. Dose-dependent concentrations in muscle (42.1 and 63.6 ng/g) were observed, with a plasma to muscle ratio of approximately 1:1. Dose-dependent TE was observed in blood with robust and sustained target engagement at 15 mg. Conclusions: Losmapimod was well tolerated with no SAEs reported and achieved dose-dependent exposure in plasma and muscle at concentrations predicted by pre-clinical models to provide efficacy by reducing DUX4 activity. These results support advancing the 15 mg dose into Phase 2. Final data will be presented. Disclosure: Dr. Mellion has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics and Vertex Pharmaceuticals. Dr. Mellion holds stock and/or stock options in Vertex Pharmaceuticals which sponsored research in which Dr. Mellion was involved as an investigator. Dr. Mellion holds stock and/or stock options in Vertex Pharmaceuticals. Dr. Mellion has received research support from Fulcrum Therapeutics and Vertex Pharmaceuticals. Dr. Ronco has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics. Dr. Ronco has received compensation for serving on the Board of Directors of Fulcrum Therapeutics. Dr. Ronco has received royalty, license fees, or contractual rights payments from Fulcrum Therapeutics. Dr. Ronco holds stock and/or stock options in Fulcrum Therapeutics which sponsored research in which Dr. Ronco was involved as an investigator. Dr. Ronco holds stock and/or stock options in Fulcrum Therapeutics. Dr. Thompson has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics. Dr. Thompson has received research support from Fulcrum Therapeutics. Dr. Hage has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics.Dr. Brooks has nothing to disclose. Dr. van Brummelen has nothing to disclose. Dr. Pagan has nothing to disclose. Dr. Badrising has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Dr. Badrising's institution (The LUMC) received compensation for consultancy and clinical trial fees from Novartis and consultancy compensation from Argen X for work done by U.B.. Dr. Raines has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics. Dr. Tracewell has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapuetics. Dr. van Engelen has nothing to disclose. Dr. Groeneveld has nothing to disclose. Dr. Cadavid has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Fulcrum Therapeutics. Dr. Cadavid has received research support from Fulcrum Therapeutics.


An optoelectronic semiconductor chip is specified, comprising a first contact location (1) and a second contact location (2), and a reflective layer (3), which is directly electrically conductively connected to the second contact location. The reflective layer contains a metal that tends toward migration, and the reflective layer is arranged in such a way that a migration path (4) for the metal can form between the second and the first contact location. A means (6) which, during operation of the semiconductor chip, forms an electric field that counteracts the migration of the metal is provided at the semiconductor chip.


ECG s ignal are widely used in all over world to find various cardiac disorder, in today's world ambulatory ECG signal recording and monitoring becoming a popular using wearab le A ECG monitor and patient can do his daily routine life for timely diagnosis and treatment of cardiac disorder, but Ambulatory ECG signal is contaminated by motion artifact due to physical body movement so it must be removed before proper clinical analysis of AECG. We have recorded AECG signal using self made A ECG recorder (Wearable device). Here four types of physical movement data taken like right hand movement, sitting to stand movement, waist and walking movement with faster and slower pace of five healthy person. We denoised AECG signal and identified motion artifact of different four physical activity using wavelet techniques. We have also taken videos of different physical activity to analy ze and verify motion art ifact in AECG signal.


Access of the wind power will change the original structure of distribution network and fault current's magnitudes,direction and so on,and then it may affect the correct action of stage current protection of distribution network. To this problem,at first,the paper analysed the mathematical model and control strategy of VSCF doubly-fed wind power generator,and stimulated of its operating characteristics on the RTDS / RSCAD. The detail of doubly-fed wind power generation of 10 k V distribution network system model was established,and through the model simulation and analysis of the effect on the original protection,the further experiments were carried out fwith the different access capacities of wind power. The result of simulation shows that the action of current protection relates to the access capacity of wind power and fault location directly.