The dextral Talas‐Fergana Fault separates the western from the central Tien Shan. Recent work has shed light on the Cenozoic evolution of the eastern and central Tien Shan; much less attention has been paid to the western Tien Shan. In this contribution we present new thermochronological ages for the Fergana and Alai ranges that, combined with the available data set, constrain the Cenozoic exhumation history of the western Tien Shan. Following a tectonically quiet early Cenozoic period, we suggest an onset of exhumation at ~25 Ma. This early onset was followed by a period of slower exhumation and in some areas minor reheating. A final, strong late Miocene rapid cooling event is well represented in the western Tien Shan as in other sectors of the range. The early onset of uplift of the western Tien Shan dissected the previously continuous westernmost Parathethyan Sea, progressively isolating basins (e.g., Fergana, Tarim, and Alai basins) in the central Asian hinterland. Moreover, the coeval timing of late Miocene uplift along the length of entire Tien Shan implies that neither the Pamir nor Tarim can be the sole driver for exhumation of the entire range.


Employing an alternative methodology and new data, the authors address the debate concerning the underlying causes of racial residential segregation. Are white Americans avoiding racially mixed neighborhoods because they do not want to live with nonwhites? And if so, is this the case independent of factors with which race is associated, such as crime levels or housing values? An over-the-telephone factorial experiment addresses these issues, measuring variables that shape white Americans' choice of purchasing a home. Based on a national, random-digit-dial survey of 1,663 white Americans, the effects of African American, Asian, and Hispanic neighborhood composition on whites' likelihood of buying a house are explored, as well as the other variables for which race may serve as a proxy. Results indicate that Asian and Hispanic neighborhood composition do not matter to whites. Black neighborhood composition, however, does matter, and matters even more for white Americans with children under age 18. The effect of black composition is net of the variables that whites offer as the primary reasons they do not want to live with blacks. The implications of these findings for segregation trends and for future research are considered.


Based on a comparative analysis of algorithms and models for the design of flexible manufacturing systems (FMS) for the reconstruction and repair of second-hand cars, the purpose and main issues of the research article were determined. The proposed method provides for the development and reconstruction of vehicles that are physically and morally worn out and need to be maintained and redesigned. The aim of the article is to develop a flexible manufacturing module (FMM) for the automated reconstruction of various second-hand car models using an integrated computer-aided design and production system (CAD / CAM). The proposed solution prevents a large amount of the client's (car owner's) time and ensures that the work will be done within the assigned time frame. It also determines the cost at the initial stage, avoiding subsequent additional costs to the client.
To implement the tasks at the initial stage, the layout scheme of the FMM was proposed and its mechatronic elements were selected. Based on CAD / CAM technology, the process of automating the design of innovative coatings and assembly of a second-hand car was carried out.
Keywords: CAD / CAM technology, flexible manufacturing module, automation of design and assembly, second-hand car, reconstruction.


There is perhaps no more iconic image in Roman art than the spoils of Jerusalem panel on the arch of Titus at Rome, which memorialises a key moment in Vespasian and Titus' triumphal parade of 71: the display of cultic vessels from the destroyed Jewish temple. In this paper I suggest that in the eyes of the Romans, the cultic vessels displayed in the spoils panel on the arch of Titus represented the God of Israel, captive and paraded through the streets of Rome. From the Roman point of view the destruction of the Jerusalem temple marked the end of the cult of the Jewish God, who was subjugated to Capitoline Jupiter. Hadrian's reconstruction and dedication of Jerusalem to Capitoline Jupiter sixty years later represent the culmination of this process. In contrast, Josephus' writings reaffirm a belief in the continued existence of the God of Israel and the anticipation of an eventual reestablishment of a sacrificial cult in the face of the contrary assumption among the Romans.


Objective: The purpose of this study was to analyze the line of treatment and its outcome in cases of endometriosis presenting with infertility and pelvic pain at a tertiary center having facilities of operative endoscopy and assisted reproductive technology.Methods: All cases of Infertility and pelvic pain over a period of two years were subjected to laparoscopy. Patients who were diagnosed with endometriosis were classified into categories. Different system of classification was used for patients of Infertility and pelvic pain. A large number of patients were subjected to expectant management. Selected cases underwent IUI, IVF-ET and ICSI. The numbers of pregnancies were recorded in these cases. Patients with pelvic pain were treated with hormonal therapy.Results: 1038 patients were studied over a period of 2 years out of which 983 presented with Infertility and 55 with pelvic pain. 294 cases of infertility were detected and biopsy proven to be having endometriosis and 20 of the 55 cases of pelvic pain were also detected to have endometriosis. In the infertility group 76 patients were found to have bilateral tubal block. 215 patients were detected to have various grades of lesions but with patent bilateral/unilateral tubes. 6 patients with blocked tubes and 11 patients with patent tube/tubes also were associated with male factor infertility. 88 patients with blocked tubes and/or male factor received treatment with IVF-ET/ICSI. 178 patients underwent ovulation induction and 28 were simply observed. There were 42.8% pregnancies in the observation group, 49.4% in the ovulation induction-IUI group and 45.4% in IVF-ET/ICSI group.Conclusion: 30% of the cases of Infertility had endometriosis. Following operative endoscopy treatment for all cases, the occurrence of pregnancy was similar in patients who were simply observed and those who received treatment with ovulation induction-IUI. Those with mechanical problems of sperm-egg union are best treated with IVF-ET where facilities exist.


There is a controversy in groundwater management: some people argue that public participation has decreased efficiency in decision-making, while others believe this process is not executed effectively. Questions about whether public participation results from the context involving influential people, the rules, or the way participation mechanisms were designed need examination. In this study, opportunities, barriers, and challenges of public participation were analyzed in the management of a coastal aquifer affected by marine intrusion in the Maneadero Valley, México. Mixed methods were implemented, involving 28 interviews with key actors and 50 surveys conducted during 2014 and 2017 with groundwater users. Results show that public participation is mainly determined by power differences, lack of continuity in the participatory processes, and the design of the participation mechanisms. State actors have greater decision-making power in integrated groundwater management. In contrast, groundwater users have limited participation in the process of making proposals, and their participation is generally passive. There are limitations to broad, informed, and responsible public participation: examples of these limitations include different levels of information, inappropriate institutional arrangements, failure to disseminate scientific information, lack of spaces to exercise public participation, and absence of political will. Hence, to improve Maneadero aquifer management, it is necessary to decentralize decision-making, integrate technical and non-technical knowledge, generate scientific evidence about water availability, and give a prominent role to stakeholders and users from the initial stages. In addition, internalization and water culture are required. These results can help to guide integrated groundwater management in other arid regions.


The relative expression levels and number of microRNA (miRNA) response elements (MREs) are important parameters to determine the magnitude of the competing endogenous RNA (ceRNA) effect.(1) We agree that circular RNAs (circRNAs) express much less than certain microRNAs (miRNAs) and cannot be predicted to function as a sponge nearly as effectively as cerebellar degeneration related protein 1 antisense RNA (CDR1as). Consistent with this understanding, of the 177 circRNAs that were abnormally expressed in the very early stage of hepatocellular carcinoma (HCC), bioinformatics analysis revealed that only 52 circRNAs may act as miRNA sponges, and circular chromodomain Y like (circ-CDYL) was the one we confirmed experimentally in this study.(2).


Quasi-phasematched second order nonlinear optical interactions in periodically poled Ti:LiNbO3 channel waveguides, directional couplers and waveguide arrays are exploited to develop efficient all-optical wavelength converters, parametric amplifiers, time division (de-) multiplexers, and space-, phase-, and polarisation-switches. Introduction During the last years optical channel guides of excellent quality have been developed in Periodically Poled Lithium Niobate (PPLN), using either (annealed) proton exchange (APE) or Ti-indiffusion for fabrication. APE:PPLN guides usually have a somewhat smaller cross-section, yielding a higher (normalized) efficiency of nonlinear optical interactions [1]. On the other hand, Ti:PPLN channels have very low losses down to 0.03 dB/cm. Their excellent homogeneity over a length of up to 90 mm enabled the development of very efficient quasi-phasematched quadratic nonlinear integrated optical devices for ultrafast all-optical signal processing. (Simultaneous multi-) wavelength conversion, dispersion compensation, parametric amplification, λ-selective time division (de-)multiplexing, phaseand polarisation-switching as well as spatial switching have been demonstrated [2]. Moreover, homogeneous nonlinear directional couplers and waveguide arrays with up to 100 coupled channels have been developed to demonstrate new all-optical switching concepts. It is the aim of this contribution to review all-optical signal processing mainly in Ti:PPLN channel guides, but also in directional couplers and waveguide arrays. Applications in the field of optical communications are emphazised. Wavelength conversion All-optical wavelength conversion based on quadratic nonlinear interactions in Ti:PPLN channel waveguides offers a broad bandwidth or tuning range, respectively, quantum-limited noise, and ultrafast response and operation speed. Second Harmonic Generation (SHG), Difference Frequency Generation (DFG), cascaded SHG and DFG (cSHG/DFG), Sum Frequency Generation (SFG), and cascaded SFG and DFG (cSFG/DFG) have been exploited for efficient λ-conversion. In cSHG/DFG a strong fundamental wave at λf is used to generate via SHG a pump wave at λp = λf /2 to allow simultaneous DFG with a signal at λs (see Fig. 1). Fig. 1: Scheme of cSHG/DFG in a Ti:PPLN waveguide; a periodicity of about 17 μm is used for phase matched nonlinear interactions in the NIR. By the second process a λ-converted signal the idler wave is generated at λi with λi -1 = 2λf -1  λs . As this process is accompanied by spectral inversion of the signal, it can also be used for mid-span dispersion compensation in fiber optical communication links. Moreover, simultaneous multi-wavelength conversion is possible. As an example, Fig. 2 presents the simultaneous λ-conversion of the emission of two DFB lasers, of an extended cavity semiconductor laser (ECL) and of an actively mode-locked fibre laser (5 ps; 10 GHz) at ITU-wavelengths of 200 GHz channel spacing. 175 mW of fundamental power was fed to the input pigtail of the Ti:PPLN wavelength converter of 16.6 μm domain periodicity operated at 188.5 C. A conversion efficiency of –10dB was achieved in a spectral range of about 55 nm (FWHM) width [3]. Fig. 2: Output spectrum of a Ti:PPLN wavelength converter for multichannel operation by cSHG/DFG. 155


This paper was written at the Institute for Advanced Study, to which we are grateful for support. We also thank Carles Boix, William Ferguson, Sumon Majumdar , Jan-Werner Müller, and Ira Katznelson for helpful suggestions and members of the School of Social Science lunch table for useful discussions. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research.


Distribution-to-distribution-based lidar odometry is known for its good accuracy, while it cannot run in real-time when the number of points is large. To alleviate this problem, Faster Generalized Iterative Closest Point (FasterGICP) is proposed in this letter, in which an acceptance-rejection sampling-based two-step point filter is proposed to exclude the points that rarely benefit the lidar odometry performance. Specifically, the lidar point cloud is firstly filtered and only the points with high planarity tend to be preserved, which can reduce the distribution approximation errors when the GICP works as a plane-to-plane Iterative Closest Point (ICP). Secondly, during the pose estimation optimization process, the lidar points are further iteratively filtered according to their contributions to the optimization objective function, in which the point's matching error defines the contribution. The two-step filtering process is achieved by designing the target and proposal distributions in the acceptance-rejection sampling framework. With the help of the point filter, our odometry can work in a scan-to-model strategy while demonstrating both efficiency and accuracy improvements. Extensive validation experiments are conducted on the public and our datasets. The results demonstrate that our method can achieve competitive performance compared with the state-of-the-art lidar odometry and Simultaneously Localization and Mapping (SLAM) methods. Our code has been made public available at https://github.com/SLAMWang/fasterGICP.


An analysis is made of the complex problems (retina image, time process of the visual sensation, visual acuity) of the human visual mechanism in relation to the safety of road traffic. The subject is developed theoretically in conjunction with experiments relating to the optic messages which the road and its marginal signals can transmit to the driver. (TRRL)


I N THE SURFACE Great Expectations is simply another very good example of that perennial genre, the education novel. In particular, it is the story of a restless young boy from the lower classes who comes into possession of a fortune he has done nothing to earn, founds a host of romantic aspirations upon it at the cost of becoming a snob, comes to be disappointed both romantically and socially, and, finally, with a more mature knowledge of himself and the world, works out his regeneration. As such, the novel is what G. K. Chesterton once called it, "an extra chapter to 'The Book of Snobs."' But while admitting that Pip is a fairly good specimen of a certain type of mentality so dear to Dickens's satirical spirit, we cannot overlook the fact that Dickens is using his character to reveal some still more complex truths about society and its organization. Though its shorter length and more compact organization have prevented it from being classed with Bleak House, Little Dorrit, and Our Mutual Friend, Great Expectations is really of a piece with that great social "trilogy" of Dickens's later years. In the briefer novel Dickens is attempting only a slightly less comprehensive anatomization of social evil; thematically, the implications of Pip's story are almost as large. Consider, for instance, how many different strata of society are gotten into the comparatively small number of pages that story takes up. In the first six chapters alone we meet members of the criminal, the military, and the artisan classes, together with a parish clerk and two well-to-do entrepreneurs. The


This paper is a result of a research project conducted in a Floridian county transit for one year. The primary objective of the paper is to present the study of the impact of automation on "total productivity" in bus transit. This was accomplished by first developing and applying a methodology for measuring the total productivity of the transit facility and then using the Total Productivity Model (TPM) and statistical techniques to measure the impact of automation on total productivity over a period of time. This paper bears a significant value to a transit manager, in that the methodology presented here can be applied to prospective technologies before they are acquired.


We investigate reactions of peroxide etches on 〈100〉 surfaces of In0.53Ga0.47As by measuring the pseudodielectric function 〈e〉 with spectroscopic ellipsometry. By comparing these data to calculations in the Bruggeman effective medium approximation, we find that residual 10–80 A layers of low density oxide, amorphous arsenic, or mixed oxide–arsenic compositions are formed depending primarily on solution pH. The chemical identity of these overlayers is in accord with their known solubility dependence on pH. Etch compositions previously shown to reduce reverse‐ leakage currents in In0.53Ga0.47As photodiodes correspond to those for which arsenic precipitates at the surface.


Taking ginsene as material,the different soil soluble protein content of ginseng cultivation,the nitrogen content of the soil were compared and analyzed,and the laws of water-soluble protein content of ground ginseng was studied.The results showed that ginseng grew in farmland,its content of total water-solubility protein and the major protein subunits were higher than the ones in humus soil;the nitrogen content in farmland soil was higher.It's may be conducive to the synthesis of proteins for ginseng grows in farmland soil.


Communism everywhere it settled aimed to create a new society and the 'new man' in the shortest possible time. In order to put into practice such social engineering, it was necessary that those social categories refractory to change to be annihilated. There-fore, the former politicians, the landlords, the wealthy peasants (the kulak), the bour-geois, the intellectuals, the artists were methodically and constantly repressed. Laws, institutions and people were summoned to effect change through repressive methods. The beginning of the process of building the communist society created many 'enemies of the people', as the communists described them, victims of the class struggle, but also of their own ideals. Belief in the 'Arrival of the Americans', and in the short duration of Communism led them directly to prisons, hard labor and deportation camps. Many perished, but most escaped and returned to the society that was reconfiguring itself on new bases and with new values. The fall of communism brought their recognition as 'victims' of the totalitarian regim's politics. In order to acknowledge their suffering the postcommunist Romanian state offers them compensations, granted them the label of 'anti-communist fighter', and eventually condemned Communism as 'illegitimate and criminal'. My paper discusses all these issues while pointing out what was at stake in organized repression during communism as well as in recognizing the suffering of the repressed in the first postcommunist decades.


The invention provides a pipeline laser washing device based on a curved surface holophote.The pipeline laser washing device comprises a laser, a lens system, the curved surface holophote and a motor, and the centers of the laser, the lens system, the curved surface holophote and the motor are located on the same straight line; the laser and the lens system are spaced by a certain interval so that laser light emitted by the laser can be collimated by the lens system, and light collimated by the lens system changes into annular parallel light entering the curved surface holophote in a parallel incident mode; the curved surface holophote is connected with a lead screw of the motor so that the curved surface holophote can move in the first direction when the lead screw rotates clockwise, and the curved surface holophote can move in the second direction when the lead screw rotates counterclockwise.By means of an optical shaping system and a parabolic reflector, the focus point of the emitted laser light can be located on the surface of a pipeline, and accordingly high unit area power can be acquired with low average power, pollutants evaporate, gasify or decompose instantly, and the heat conduction loss is reduced.The emitted laser light is annular focusing light and is high in pipeline washing efficiency.


Fast wire scanners were developed to measure the transverse density distributlons of LEP bunches. Secondary emission will provide the profile of the beam core. Bremsstrahlung emission re suiting from the bean-wire interaction will permit investigation of vary low density tails. Monitors will be installed at dispersion-free locations and will provide an absolute measurement of beam dimensions. Tests of a mechanical prototype have shown that the required speed and resolution can be achieved


208 This was truly a collaborative effort, and we want to thank Jeff Rufo and Sara Ritchey for their work on this project. A word on the professional roles of the present authors: we are (were, in the case of Stevens, who left CI in the fall of 2004) the two full-time staff members of the journal; as such we sit in the monthly editorial board meetings during which six to eight essays are discussed as possible candidates for publication. Also, we see all and sometimes write, from notes from the editorial board meetings, the rejection and acceptance letters. Our principal task, of course, is to copyedit manuscripts for publication. Because the character of a journal is partly determined by those who run it, we thought it important to note that, unlike many other journals, which rotate its editors every few years, CI's personnel—its editor, coeditors, and staff—has seen little change. This paper began as a talk that Jay Williams gave in 2004 at a conference, "Critical Inquiry: The End of Theory?" organized by Wang Ning at Tsinghua University in Beijing. Thanks to the audience at that talk for their comments and suggestions. Thanks also to Wang Ning, W. J. T. Mitchell and CI 's coeditors, John Tresch, Rafeeq Hasan, Alan Liu, Aeron Hunt, Denise Tillery, Robert Huddleston, Kate Gaudet, and Abigail Zitin. The Footnote, in Theory


According to the problem of low efficiency of KD-Tree's serial construction method,this paper focuses on KDTree's parallelizing construction methods.Firstly,by analyzing serial construction method and using GPU's parallelizing charac teristics,methods are improved.Secondly,by comparison of different methods,parallelizing construction method on GPU assure the accuracy and as well as the time complexity.


Offenders from the Ngaanyatjarra Lands should be held at the prison facility in Warburton for the best chance of being rehabilitated, according to Elder Daisy Ward.


In the present paper, a modified optimal profit model with settings of production and process parameters is proposed, where the larger-the-better product characteristic with the one-sided lower specification limit is considered. The product characteristic is assumed to be normally distributed with unknown mean and known standard deviation. The selling price of product is assumed to be linearly proportional to its warranty period. We also assume that the retailer's order quantity is negatively correlated with the wholesale selling price and is positively correlated with the warranty period. The single sampling rectifying inspection plan is adopted for determining the quality of product lot. The Taguchi's quadratic quality loss function is addressed for measuring the used cost of customer for product. The optimal manufacturer's process quality level, production run length, warranty period, and retailer's order quantity can then be simultaneously determined by maximizing the expected total profit of society including both the manufacturer and the retailer. Numerical results show that the longer warranty period and the higher product quality level will lead to the larger expected total profit of society. Arabian Journal for Science and Engineering (Arab J Sci Eng) Research Article Systems Engineering February 2015, Volume 40, Issue 2, pp 645-658 A New Kernel-Based Classification Algorithm for Systems Monitoring: Comparison with Statistical Process Control Methods  Foued Theljani , Kaouther Laabidi , Salah Zidi , Moufida Ksouri


Children can swim for free at Sandwell`s leisure centres during school holidays. Kids can get signed up now to enjoy free swimming during next week`s half-term break.


Recent advances in the understanding of pain physiology and pharmacology have provided dental practitioners with more reliable information upon which clinical decisions in the treatment of endodontic pain can be based. One of the effective strategies currently used in these cases is structured to evaluate the painful condition through a 3-D approach which establishes a differential diagnosis, definitive treatment, and rational use of drugs, based on the most appropriate scientific evidence available in the literature. This article provides practical treatment strategies based upon current scientific evidence and uses information presented in the articles.


Bowles: 'what they talked about can only be conjectured' ventures Speck (206). Speck is, it seems, tempted to be ironical – yet we sympathise when he draws back. For Southey to do anything as 'flagitious' as having illicit sex ('flagitious' is one of his most-favoured words), is clearly inconceivable. His stoicism was one feature he did not share with either Shelley or Byron. These two books are excellent as biographies: as criticism, they're a bit shy. Peter Cochran DOI: 10.3366/E1354991X08000287


Connecting tube portion (12) constituting a suction member (10) including at least a first connecting tube (21) swingably connected to the suction member body (11) and rotatably connected to the first connection of the first tube (21) second connecting pipe (22). In the side of the second connecting tube (22), by means of a wheel mounting portion (14) is provided with a wheel portion (13). A wheel mounting portion (14) is attached to a wheel supporting body (32), the wheel support portion of the wheel (13) (32) capable of tilting operation center portion thereof as a fulcrum.


Foreword and acknowledgments Abbreviations Introduction 1 Transnationalism before the nation-state 2 Civilising the colonials 3 Human rights for indigenous 4 Radical transnationalism 5 Indigenous peoples and international institutions 6 Domesticating indigenous politics in Caging transnationalism Epilogue Notes References Index.


Television became a possible medium for advertising in the late 1930s but its emergence as a major medium dates from 1947. Arguments about the likely effectiveness of television as a source of entertainment attracting large numbers of viewers were coloured by fears of responses to ill‐devised uses by advertisers of the presentation of products or services. The profitability of television selling was forshadowed in 1947.


In this study, the Klein–Gordon equation in one spatial dimension is solved exactly for the generalized asymmetric Woods–Saxon potential containing the various forms of physical potentials, such as the usual Woods–Saxon, asymmetric Hulthen, usual Hulthen, asymmetric cusp and usual cusp potentials. The solutions that describe the scattering and bound states of the Klein–Gordon particles are obtained in terms of the hypergeometric functions. Using the boundary conditions satisfied by the wave functions and considering the asymptotic behavior of the wave functions, we examine a condition for the transmission resonances of the relativistic spinless particles in view of the generalized asymmetric Woods–Saxon potential. Furthermore, dependence of the transmission coefficients on the generalized asymmetric Woods–Saxon potential parameters as well as the energies of Klein–Gordon particles is investigated numerically by using the Mathematica Software.


The University of Maryland's participation in TREC's 2017 Dynamic Domain track focused on two types of experiments: adding new terms from passages judged as being relevant, and exclusion of terms from documents that the track's jig feedback system indicated were not relevant to the topic. The best results for iterative multi-step retrieval were obtained by restricting retrieval to documents that contained all topic terms, and then ranking those documents using terms extracted from known relevant passages. Introduction The participation of the Computational Linguistics and Information Processing Lab at the University of Maryland (UMD_CLIP) in TREC 2017 Dynamic Domain track (TREC-DD) focused on characterizing user intent from jig feedback, and on improving over a simple no-feedback baseline that performed a single query using TREC-DD topic terms and then sequentially returned the documents in rank order, going deeper in that list with every iteration. Our experimental conditions can be categorized in two ways: adding relevant terms, and excluding irrelevant terms. We obtained our best results from an approach that required the inclusion of the original topic terms and then ranked that subset based on the presence of terms from relevant passages, as provided by the TREC-DD jig—the system through which relevance feedback was provided. General Approach We implemented all of our methods using the Indri information retrieval system from the University of Massachusetts using Indri's default ranking function with stemming disabled. All of our results are for the automatic condition, with no human intervention. Each TREC-DD run1 involves repeatedly submitting iterations of 5 document results at a time, until a total of 25 documents (5 iterations of 5 results) have been submitted. The TREC-DD track coordinators allowed up to 10 iterations per run; however, we stopped after 5 iterations as a static estimate of the state where the user's information need has been met. 1 Here we use "run" in the usual TREC sense to mean the complete set of results on which an aggregate score is computed. Each run in our submissions contained five iterations, containing no more than five documents per iteration. 2 In every run, our first iteration (i.e. set of 5 document results) was obtained by using the TREC topic terms as the query, performing ranked retrieval, and submitting the top 5 results to the jig—the system that provided simulated user feedback. We then formulated the query for each subsequent set of 5 submitted document results separately, based solely on the topic terms and the 5 results reported as relevant or as not relevant by the jig for the immediate prior query. Stopwords were consistently removed from the TREC-DD topic and from documents in the result sets before queries were formed. To avoid submission of duplicates, we maintained a running list of submitted documents for each run, and any documents on that list were removed from the result set before selecting the 5 document results to submit to the jig. Our principal focus is on Normalized Cube Test (nCT) results, the normalized version of the Cube Test (an evaluation measure used in all three TREC-DD tracks). For completeness, we also report Cube Test (CT), Average Cube Test (ACT), nCT, Session Discounted Cumulative Gain (sDCG), normalized sDCG (nsDCG), Expected Utility (EU), and normalized EU (nEU) results. Official Runs Official runs are those runs that are submitted on time and scored by NIST. We submitted three official runs to TREC-DD 2017: clip_baseline: Our baseline run performed a single search using the topic terms as the query and then iteratively returned the first 25 documents, five at a time, ignoring any relevance feedback from the jig. clip_addwords: Our addwords run used positive feedback to perform query expansion. As always, the first query was formed only from topic terms. Subsequent queries were formed from topic terms plus terms from documents reported by the jig to be relevant. Each term (from the topic or from the positive feedback expansion set) was given equal weight. clip_filter: Our filter run used positive feedback to perform reranking. Indri's filter operator performs a Boolean conjunction (i.e., an AND operator) over the "required" term set and then reranks the remaining documents using an "optional" term set. We used the topic terms as the required term set and the terms found in the relevant document as the optional term set. The expansion terms in our addwords run and the optional terms in our filter run were identical. Our unconstrained approach to positive feedback (removing only stopwords) resulted in term sets ranging from small numbers—less than ten—to several hundred new terms. For the baseline run we searched the full New York Times (NYT) collection (1987-2007). Because of a configuration error, the other two official runs searched only the first half of the collection (1987-1997). We therefore focus on our baseline run results here, and we report unofficial results below for our addwords and filter runs with the entire collection.


This work deals with the analysis of heat generation and dissipation in the disc brake of a car during braking and the following release period by using computer-aided engineering software for three different materials of the rotor disc and brake pad. The objective of this work is to analyze the temperature distribution of rotor disc during operation using COMSOL Multiphysics. The work uses the finite element analysis techniques to calculate and predict the temperature distribution on the brake disc and to identify the critical temperature of the brake rotor disc. Conduction, convection and radiation of heat transfer have been analyzed. The results obtained from the analysis indicates that different material on the same retardation of the car during braking shows different temperature
distribution. A comparative study was made between grey cast iron (GCI), Aluminium Metal Matrix Composite (AMMC), Alloy steel materials are used for brake disc and the best material for making brake disc based on the rate of heat dissipation have been suggested.


The Arabic world's language situation is characterized by bilingualism (diglossia), as alongside the written language (Fusha), there exist many spoken languages. This situation raises important theoretical and methodological issues before the theatre in general and theatrical pedagogics in particular. The article deals with the problem of orthoepic norms' lacking in spoken Arabic, which affects both the teaching methods in theatrical high schools and the speech culture in general. In this context, the author gives a short review of language development in Arabic theatre and considers some points of view of Arabic theatrical directors and playwrights of different periods. The article represents a table of phonetics' comparison of Arabic literary and spoken languages. Furthermore, the article raises the problem of spoken language codification and also considers the issue of theatre language. Emphasizing the importance of both the written and spoken languages, the article concludes on the ambivalent approach to forming the theatrical speech teaching methods in the Syrian theatrical school, provided that local dialects are standardized and actors-students master the capital dialect along with the literary language. In practice, teachers have to combine the written language acquisition basing on the rules, and that of the spoken language using audio samples.


Thioredoxin, despite its function as an intracellular disulfide reducing enzyme and its lack of a signal sequence, has been found to play some roles extracellu- larly. Here we show that thioredoxin is actively secreted by a variety of normal and transformed cells, including fibroblasts, airway epithelial cells, and activated B and T lymphocytes. Neither brefeldin A nor dinitrophenol, two drugs that block transport through the exocytic pathway, inhibit secretion of thioredoxin, indicating that the latter does not follow the classical ER-Golgi route. The secretory mechanism for thiore- doxin shares several features with the alternative pathway described for interleukin-18, such as the po- tentiating effect on secretion of several unrelated drugs and the sensitivity to methylamine. However, unlike interleukin-18, thioredoxin is not detected in membrane-bound compartments of secreting cells. In addition, when COS7 are transfected with plasmids encoding pro-interleukin- 18 or thioredoxin, only the latter is detectable extracellularly. novel of secretion, alternative the


A proposed method of processing the outputs of multiple gyroscopes to increase the accuracy of rate (that is, angular-velocity) readings has been developed theoretically and demonstrated by computer simulation. Although the method is applicable, in principle, to any gyroscopes, it is intended especially for application to gyroscopes that are parts of microelectromechanical systems (MEMS). The method is based on the concept that the collective performance of multiple, relatively inexpensive, nominally identical devices can be better than that of one of the devices considered by itself. The method would make it possible to synthesize the readings of a single, more accurate gyroscope (a virtual gyroscope) from the outputs of a large number of microscopic gyroscopes fabricated together on a single MEMS chip. The big advantage would be that the combination of the MEMS gyroscope array and the processing circuitry needed to implement the method would be smaller, lighter in weight, and less power-hungry, relative to a conventional gyroscope of equal accuracy. The method (see figure) is one of combining and filtering the digitized outputs of multiple gyroscopes to obtain minimum-variance estimates of rate. In the combining-and-filtering operations, measurement data from the gyroscopes would be weighted and smoothed with respect to each other according to the gain matrix of a minimum- variance filter. According to Kalman-filter theory, the gain matrix of the minimum-variance filter is uniquely specified by the filter covariance, which propagates according to a matrix Riccati equation. The present method incorporates an exact analytical solution of this equation.


Semiconductor structures using ferromagnetic semiconductors as spin injectors are promising systems for future spintronic devices. Here, we present combined photoluminescence (PL) and time-resolved magneto-optical experiments of a nominally nonmagnetic quantum well(QW) separated by a thin barrier from a ferromagnetic Ga(Mn)As layer. Due to the partial quenching of the PL, we conclude that there is a significant Mn backdiffusion into the QW. Moreover, from the time-resolved measurements, we infer that the Mn leads to n-type doping within the QW, and, in addition, strongly increases the electron spin dephasing time.


Aims: Improvements in technology and access have led to growing adoption of continuous glucose monitoring (CGM). Targets for glucose metrics including time in range (TIR) have been published. We aimed to investigate i) the proportion of people with ≥70% TIR and ii) the proportion with ≥70% TIR and Methods: Data were collected from 2015 to 2019 from the Cornerstone4Care (C4C) database, a freely available patient support program for people with both type 1 diabetes (T1D) and type 2 diabetes (T2D) on any treatment type. CGM traces were divided into 14-day periods according to the ambulatory glucose profile (AGP)-reporting system. Only profiles with data aligned with these standards were included. Patient data are presented using the first or the mean of all AGP profiles. Results: In total, 484 persons uploaded CGM-data to the database (4727 AGPs); 242 had T1D and 74 had T2D (self-reported), the rest were unknown (Table). People uploaded between 1 and 75 AGPs (mean=10). Average TIR (70-180 mg/dL) based on mean profiles was 63%, 68% and 64% for T1D, T2D and all, respectively. Conclusions: Less than half of the population achieved ≥70% TIR, ~30% with ≥70% TIR and Disclosure R. M. Bergenstal: Advisory Panel; Self; Abbott Diabetes, Eli Lilly and Company, Novo Nordisk, Onduo LLC., Roche, Sanofi, United Healthcare, Consultant; Self; Abbott Diabetes, Ascensia, Dexcom, Inc., Eli Lilly and Company, Hygieia, Johnson & Johnson, Medtronic, Novo Nordisk, Onduo LLC., Roche, Sanofi, United Healthcare, Other Relationship; Self; HealthPartners Institute, Research Support; Self; Abbott Diabetes, Dexcom, Inc., Eli Lilly and Company, Helmsley Charitable Trust, Hygieia, Johnson & Johnson, Medtronic, NIDDK, Novo Nordisk, Onduo LLC., Roche, Sanofi, United Healthcare. E. Hachmann-nielsen: Employee; Self; Novo Nordisk A/S. J. Tarp: Employee; Self; Novo Nordisk. K. Kvist: Employee; Self; Novo Nordisk A/S. J. B. Buse: Consultant; Self; Cirius Therapeutics, CSL Behring, Fortress Biotch, Mellitus Health, Moderna, Pendulum Therapeutics, Praetego Inc., Stability Health, Zealand Pharma A/S, Other Relationship; Self; AstraZeneca, Eli Lilly and Company, Novo Nordisk, vTv Therapeutics, Research Support; Self; NovaTarg Therapeutics, Novo Nordisk, Sanofi, Tolerion, Inc., vTv Therapeutics, Stock/Shareholder; Self; Mellitus Health, Pendulum Therapeutics, PhaseBio Pharmaceuticals, Inc., Stability Health. Funding Novo Nordisk A/S


Postsecondary co-enrollment, or simultaneous enrollment at multiple institutions, is becoming increasingly common among U.S. college students. This descriptive analysis documented the characteristics and co-enrollment patterns of Latinx/a/o students in the Beginning Postsecondary Students Longitudinal Study (12/17). Findings of the study revealed that Latinx/a/o students co-enrolled at multiple postsecondary institutions at greater rates than all students combined, and that persistence and bachelor's degree completion rates were higher for co-enrolled Latinx/a/o students than for all Latinx/a/o students.


Discharge to an in-patient rehabilitation facility or another acute care facility not only constitutes a postoperative challenge for patients and their care team but also contributes significantly to health-care costs. In the era of changing dynamics of healthcare payment models where the risk of cost over-runs are being increasingly shifted to surgeons and hospitals, it is important to understand better outcomes such as discharge disposition. In the current manuscript, we sought to develop a predictive model for factors associated with nonroutine discharge after surgery for grade I spondylolisthesis.

 We queried the Quality Outcomes Database for patients with grade 1 lumbar degenerative spondylolisthesis undergoing a surgical intervention between July 2014 and June 2016. Only those patients enrolled in a multiside study investigating the impact of fusion on clinical and Patient Reported Outcomes (PROs) among patients with grade 1 spondylolisthesis were evaluated. Nonroutine discharge was defined as those that were discharged to postacute or nonacute care setting in the same hospital or transferred to another acute care facility.

 Of the 605 patients eligible for inclusion, 9.4% (n = 57) had a nonroutine discharge (8.7%, n = 53 discharged to an inpatient postacute or nonacute care in the same hospital and 0.7%, n = 4 transferred to another acute care facility). On multivariable logistic regression, after adjusting for an array of demographic, socioeconomic, clinical, and operative variables, factors found to be independently associated with higher odds of nonroutine discharge included higher age (OR 10.53, 95% CI 3.8-29.2, P < .001), higher BMI (OR 2.42, 95% CI 1.45-4.05, P < .001), depression (OR 4.97, 95% CI 2.10-11.77, P < .001), and length of stay (OR 3.4, 95% CI 2.3-4.9, P < .001).

 In this multisite study of a defined cohort of patients undergoing surgery for grade I spondylolisthesis, factors associated with higher odds of nonroutine discharge included higher age, higher BMI, presence of depression, and higher length of stay.


Abstract As a biomedical hard tissue implant candidate, porous Ti–Mo alloy has received considerable attention because of its special porous structure, appropriate Young's modulus and compressive strength as well as good corrosion resistance. As a bioactive coating, hydroxyapatite is commonly used to cover the surface of bioinert metallic prostheses due to its excellent biocompatibility, bone-like structure and composition. This article reviews the current developments and the relationships between the fabrication methods, porous structure, mechanical properties, bioactive surface modification and corrosion behavior of porous Ti–Mo alloy used for hard tissue implant application. Furthermore, the future research directions are discussed to optimize the porous structure and improve the properties of porous Ti–Mo alloys.


This paper introduces a new cascade configuration of inverted T-type LC EMI chip filters. Initially, two different types of T-type LC filters, produced by a multilayer green sheet technology, were characterized and modeled in the frequency range from 0 to 3 GHz, and then combined into a cascade configuration of inverted T filters. The equivalent circuit model developed for the basic T-type LC chip was used to characterize this configuration using the schematic interface in Microwave Office (MWO), an integrated RF/Microwave design tool. MWO built-in electromagnetic simulator using geometric structure (EM) was further used to model and simulate the new EMI filters in an unbalanced configuration. All simulation results were compared with experimental results and mutual validity of the applied approaches was verified.


Immunization against hepatitis B virus (HBV) infection is recommended in patients with inflammatory bowel disease (IBD), particularly in those under immunosuppressive therapy. Limited data are available about IBD patient's response to HBV vaccination. We assessed the response rate to HBV vaccination in IBD patients and evaluated the impact of different factors on the efficacy of HBV vaccination.


Children with behaviour problems tend to be more unengaged and low-achieving at school than children without behaviour difficulties. This systematic literature review is highlighting the meaning of ...


The concept of risks management expert system in standardization, constructed on the basis of the process approach on a modular principle is offered. The algorithm of formation of expert system module is developed, allowing to put process of working out of state standard in operated conditions on criterion of the set risk level.


Gene regulatory networks (GRNs) describe epistatic relationship of genes and how the expression of some genes influence the expression of other genes. This information is critical for understanding molecular mechanisms regulating various biological processes and molecular basis of several diseases. Current research work mostly attempts to infer such regulatory relationships (and GRN architecture topology) from gene expression data. This paper improves on this methodology by utilizing additional information available that describes which cis-elements are present in which genes, and at what locations. Using the underlying principle that target genes of a transcription factor should share the same binding site in their promoter regions, we propose a scoring method that facilitates the refinement of a candidate GRN. Improvements are demonstrated with three data sets, on which GRNs are first obtained from existing dataset (AtRegNet) or using an existing approach (ARACNe), and then modified using cis-element information.


In this study, a water-based corundum suspension was used to deposit 60 μm alumina coatings onto carbon steel substrates by HVOF spraying. The aim was to develop thin coatings with superior wear properties. Hydrogen was used as a fuel gas and process parameters were varied to determine their effect on microstructure and properties. Coating microstructure was examined by SEM to assess particle melting and morphology and XRD was used to study the phase transformation of the feedstock suspension. At higher combustion flame energy, the coating transformed primarily to gamma alumina, while at lower energy, it was found to be a mixture of alpha and gamma alumina. Nanoindentation tests were used to measure the hardness and elastic modulus of individual phases. Ball-on-plate wear tests helped reveal the relationship between wear performance and the alpha-gamma ratios in the coatings.


A storage catalyst nitrogen oxide comprising: a material catalytic trap comprising an effective catalyst component for promoting the reduction of NOx under stoichiometric or rich conditions arranged on a support of refractory metal oxide, and a material of the NOx storage effective to adsorb NOx in poor conditions and desorbing and reducing the NOx under nitrogen stoichiometric or rich conditions, the material of the NOx storage particles ceria spray dried with BaCO3 or a mixture of BaCO3 and MgCO3 supported on particles comprising ceria and a refractory carrier member, wherein the material of catalytic trap is disposed on the member refractory support, and wherein the material of the NOx storage can be obtained by mixing a solution of barium particles ceria, drying spray particles, heating the dried particles pulveri tion and arranging the particles coated on a substrate.


Acute myeloid leukemia (AML) is the most common leukemia in adult patients, with a 5-year survival rate of less than 30 percent. Therefore, more effective therapeutic strategies are required to prolong the survival of AML patients. Importantly, anti-apoptotic proteins, especially B-cell lymphoma 2 (Bcl-2), overexpression in AML is associated with uncontrolled growth as well as chemoresistance. Unsurprisingly, Bruton's tyrosine kinase (BTK) overexpresses in AML and associated with poor prognosis and chemoresistance. The FDA-approved BTK inhibitor, ibrutinib, has been successful in treating other hematologic malignancies, but a proportion of patients relapse mainly because of acquired mutations at Cys481Ser (C481S) in the kinase domain of BTK. If we are to develop effective BTK-based therapeutic regimens, it is critical that we account for these likely mutations and avoid agents that target the kinase domain. To develop a more selective and effective BTK inhibitor, we modified our first-generation BTK inhibitor to avoid the C481S mutation in the BTK kinase domain. This advance allowed us to develop a second-generation BTK inhibitor, KS151, that shows in vitro potency against C481S mutants. Because BTK and Bcl-2 are critical in chemoresistance and poor prognosis, combination therapy targeting BTK and Bcl-2 is a more viable option for AML patients to achieve better therapeutic outcomes. We propose the combination of KS151 with venetoclax (ABT-199) or ABT-737 in resistant AML cells. We employed a panel of three AML cell lines: Kusami-1, U937, and THP-1. Remarkably, KS151 was able to induce AML cell death with an average IC50 of 4 μM. Furthermore, KS151 showed a significant increase in both venetoclax and ABT-737 efficacy against AML cells. Western blot analysis demonstrated that Kusami-1 cells have the highest expression of both BTK and Bcl-2 proteins. Taken further, flow cytometry (Annexin V staining) demonstrated that KS151 combined with inhibition of Bcl-2 by venetoclax synergistically induced apoptosis (approximately 95%) of Kusami-1 cells. Collectively, the combination therapy showed promising and synergistic in vitro anti-leukemic activity against AML cell lines and represents a new viable treatment for AML patients. Future studies will apply the combination strategies in AML-resistant cell lines and include assessment in patient samples and in vivo studies.
 Citation Format: Nicole K. Schmalbach, Omar S. Al-Odat, Weam Othman Elbezanti, Gabriella Yao, Daniel A. Guirguis, Krishne Gowda, Shantu G Amin, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Manoj K. Pandey. Development of a novel BTK inhibitor against resistant acute myeloid leukemia [abstract]. In: Proceedings of the AACR Special Conference: Acute Myeloid Leukemia and Myelodysplastic Syndrome; 2023 Jan 23-25; Austin, TX. Philadelphia (PA): AACR; Blood Cancer Discov 2023;4(3_Suppl):Abstract nr A01.


The publication purpose - justification of pedagogical conditions of development of professional ethics of future teachers of the educational organization, as actual direction of training of future expert who is based on the fundamental principles of universal morals, ethic and humanistic ideals and the specific principles of a profession. The professional ethics of the teacher of the educational organization as the scientific direction studying manifestations of morality and the principles of professional ethics in the field of pedagogical work, regularity of behavior and relationship in system is proved: the "teacher" - "teacher" who - is "trained" the providing contents of the rules and norms of pedagogical activity expressed in the form of ethical codes. It is shown that professional activity of the teacher of the educational organization from a position of ethics represents the system based on the principles of the world, professional and pedagogical and personal and personal ethics. The structure of professional ethics of future teacher of the educational organization presented ethic and world outlook, professional and educational, cultural and behavioural, reflexive and estimated by components is defined. The pedagogical conditions providing formation of professional ethics reveal according to logic of the offered structure. The theoretical provisions submitted in work supplement basic provisions of professional ethics and concepts of moral and professional development of the personality, enriching the theory and a technique of continuous professional education.


In this paper, concrete material tests were carried out to investigate variations of workability, compressive and splitting tensile strength, and flexural strength and toughness characteristics of steel-fiber reinforced high-strength concrete according to increase of fiber volume. Test specimens were arranged with six levels of concrete compressive strength, 30㎫, 50㎫, 60㎫, 70㎫, 8㎫, 90㎫ and fiber volume ratios, 0.0%, 0.5%, 1.0%, 1.5%, 2.0%. The test results showed that effects of steel fibers in improvement of concrete splitting tensile and flexural strength were more distinguished in high-strength concrete than general strength concrete.


ACQUIRED abnormalities of platelet function are very common. Platelet function, as assessed by in vitro studies or the bleeding-time test, is affected by a vast number of drugs, common foods, vitamins, and spices; by systemic conditions such as chronic renal disease and surgery requiring cardiopulmonary bypass; and by hematologic disorders such as myeloproliferative and lymphoproliferative diseases, dysproteinemias, and the presence of antiplatelet antibodies. The possibility that these abnormalities may underlie an increased risk of bleeding is an important issue when bleeding occurs without a clear cause or when invasive procedures are required. However, the clinical importance of platelet dysfunction is . . .


Substance use disorder (SUD) is one of the most common comorbid conditions in adults with attention deficit-hyperactivity disorder (ADHD). There are still few studies that address combined ADHD and SUD as compared to studies on ADHD without SUD. The aims of the present thesis were (1); to conduct a clinical characterization of men with ADHD in compulsory care for severe SUD; (2) to investigate whether pharmacological treatment in ADHD/SUD cases was associated with improved long-term psychosocial outcomes; (3) to explore the feasibility of DBT (dialectic behavior therapy)-based skills training in ADHD/SUD patients in compulsory care; and (4) to explore the association between the skills training and the psychosocial outcome after six months. All studies were conducted at a compulsory care institution for men. In the clinical characterization (Study I), 60 men with ADHD and SUD were compared with (1) 120 men in compulsory care for severe substance abuse without a known ADHD regarding comorbid psychiatric symptoms, psychosocial background, treatment history, and cognition, and with (2) 107 men with ADHD but without severe SUD from an outpatient psychiatric clinic. In Study II, a comparison was made between 30 patients who had received pharmacological treatment for ADHD and 30 non-treated patients. The long-term outcome was measured as the current status regarding abuse, voluntary rehabilitation, accommodation and employment, as well as mortality. In Study III, the feasibility and acceptability of DBTbased skills training were explored; 40 patients were included. The patients were follow-up six months after discharge from compulsory care, (Study IV). The outcome measures were substance abuse status, voluntary treatment status, and accommodation and employment status. The characteristics of the ADHD/SUD found in Study I were an early onset of antisocial behavior that persisted into adulthood and poor cognitive skills. Study II showed that the overall mortality was high (8.3%) and that the pharmacologically treated group had significantly better outcomes in all measured psychosocial parameters. In Study III, it was found that the DBT-based skills training for ADHD was feasible and acceptable in a context of compulsory care for SUD. Significant symptom reduction, as well as an increased general well-being, was also found. The completers of the DBT-based skills training had fewer relapses and were more often in voluntary treatments, compared to non-completers in the sixmonth follow-up study (Study IV). However, no causal conclusion regarding the relationship between the DBT-based skills training and the psychosocial outcome can be drawn due to the base-line differences between completers and non-completers, as well as the lack of a control group. To sum up, ADHD in combination with SUD is a particularly disabling condition. The combination of severe substance abuse, poor general cognitive ability, severe psycho-social problems, including indications of antisocial behavior, and other co-existing psychiatric conditions should be considered in treatment planning for adults with ADHD and SUD. Pharmacological treatment of ADHD in individuals with ADHD and severe SUD may decrease the risk of relapse and increase the patients' ability to follow a nonpharmacological rehabilitation plan and thereby improve their long-term outcomes. Use of the structured treatment setting in the compulsory care for SUD for the initiation and stabilization of the pharmacological treatment for ADHD may be beneficial for high-risk populations. Furthermore, adapted structured treatments, such as DBT-based skills training, may be feasible in compulsory care and useful for some patients in this group. Discontinuation of voluntary treatment programs during the compulsory care may indicate low motivation or ability to participate in voluntary treatment and therefore predict a negative outcome after discharge. LIST OF SCIENTIFIC PAPERS INCLUDED IN THE THESIS I. Bihlar Muld, B., Jokinen, J., Bölte, S., Hirvikoski, T. (2013). Attention Deficit/Hyperactivity Disorders with co-existing substance use disorder is characterized by early antisocial behaviour and poor cognitive skills, BMC Psychiatry, 2013, 13:336. II. Bihlar Muld, B., Jokinen, J., Bölte, S., Hirvikoski, T. (2015). Long-term outcomes of pharmacologically treated versus non-treated adults with ADHD and substance use disorder: a naturalistic study, Journal of Substance Abuse Treatment, 51(2015) 82-90. III. Bihlar Muld, B., Jokinen, J., Bölte, S., Hirvikoski, T. DBT-based skills training for men with ADHD and SUD in compulsory care: a feasibility study, ADHD Atten Def Hyp Disord DOI 10.1007/s12402-016-0195-4 IV. Bihlar Muld, B., Jokinen, J., Bölte, S., Hirvikoski, T. Brief report: Six months post-discharge follow-up of structured skills training groups for men with ADHD in compulsory care due to substance abuse – an open study (submitted). PUBLICATIONS NOT INCLUDED IN THIS THESIS


1. A pharmaceutical composition for the stabilization of sensitive plaques in blood vessels in a subject in need of such a stabilization, or intended for preventing or treating restenosis in diabetic patients, which contains rapamycin or a derivative thereof capable of inhibiting mTOR, in combination with one or more pharmaceutically acceptable diluents or carriers. ! 2. Use of rapamycin or a derivative thereof having the ability to inhibit mTOR, for the manufacture of a medicament for stabilizing sensitive plaques in blood vessels in a subject in need of such a stabilization, or for the prevention or treatment of restenosis in diabetic patients. ! 3. Use or composition according to claim 1 or 2, for use in combination with one or more active co-agent. ! 4. The use or composition according to claim 1 or 2, wherein the rapamycin derivative having the ability to inhibit mTOR, is 40-O- (2-hydroxyethyl) -rapamycin. ! 5. A device or system for administration of a medicament comprising I) a medical device adapted for local application or administration in hollow tubular bodies and II) derived therapeutic dose of rapamycin is capable of inhibiting mTOR, rapamycin or in combination with a therapeutic dose of one or more active co-agent selected from the group consisting of EDG-receptor agonist having limfotsitistoschayuschimi properties, cox-2 inhibitor, pimecrolimus, a cytokine inhibitor, a chemokine inhibitor, an antiproliferative agent, a statin, a protein growth factor or cos


One observes that a considerable level of confusion remains about some of those aspects of irreversibility, entropy generation and `the arrow of time' which actually are well understood. This demands that great care must be taken in any discussion of irreversibility to use clear-cut notions and precise language in order to be definite about which property follows from which assumption. In this work, a novel toy model of `algebraic mechanics' is presented that elucidates specific key aspects of entropy generation in a system with extremely simple reversible fundamental dynamics. It is argued why insights gained through a detailed quantitative study of this toy model also have to be taken into account for any realistic model of microscopic dynamics, classical or quantum alike. As irreversibility also touches upon the quantum mechanical measurement process (through the `proof' of the `H-Theorem'), a simple way to address the tenacious question `when (and how) the wave function collapses' is offered.


Activity-based costing is ideally suited to downsizing and restructuring support departments that handle functions such as personnel, accounting, administration, and materials management. Using the Charleston, South Carolina, Naval Shipyard as an example, this article shows how combining activity-based costing and value-added analysis techniques made support activities visible and understandable, facilitated the restructuring of support functions, helped judge which activities were necessary, and improved the cost and performance of activities.


Abstract Objectives: Paid care provided in the home or through community organizations includes important support services for older adults with dementia such as cleaning and personal care assistance. These services could delay the transition to long-term care, but access may differ across sociodemographic groups. This study examined the relationship between paid care and transitioning out of the community among diverse older adults with dementia. Methods: Using data from 303 participants (29.4% Black) with probable dementia in the National Health and Aging Trends Study (2011-2019), subdistribution hazard models estimated the association between receiving paid care at baseline and the probability of transitioning out of the community over the next eight years. Covariate selection was guided by the Andersen model of healthcare utilization. Results: Paid care was associated with lower risk of transitioning out of the community (SHR = 0.70, 95% CI [0.50, 0.98]). This effect was similar after controlling for predisposing factors and most prominent after controlling for enabling and need for services factors (SHR = 0.63, 95% CI [0.42, 0.94]) and was only evident among Whites. There were no racial differences in the use of paid care, but Black participants were less likely to transition out of the community than Whites despite evidencing greater care needs. Discussion: Paid care services may help delay transitions out of the community. Future research should seek to explain racial differences in access to and/or preferences for home-based, community-based, and residential care.


Digital cameras, laptop computers, cellular phones, as well as many portable electronic devices require batteries for powering. Based on the electrolyte type, electrolytic batteries can be categorized into solid-based, liquid-based, and ionic-based batteries. Aluminum ion batteries (AIBs) have some promising properties such as low cost, high safety, and high specific volumetric capacity. Nevertheless, in order for AIBs to be extensively used, developing novel electrode materials possessing high energy density is requires. This is mainly dependent on the cathode materials. However, these cathode materials have some drawbacks such as structural decomposition, low battery capacity, low discharge voltage, and volume expansion resulted from the intercalation of large-sized ions. Therefore, future research might concentrate on the investigation of cheaper electrolyte and novel cathode materials for enhancement of energy density and working voltage. This review focuses on the recent cathodes, in particular, composite cathode materials, including graphite, CuS, V2O5, Li3VO4@C, VS4/rGO, and Ni3S2/graphene.


AIMS Managed care is a market model of health care distribution, aspects of which are being incorporated into the Australian health care environment. Justifications for adopting managed care lie in purported claims to higher levels of efficiency and greater 'consumer' choice. The purpose of this research, then, is to determine the ethical implications of adapting this particular administrative model to Australia's health care system. In general, it is intended to provide ethical guidance for health care administrators and policy-makers, health care practitioners, patients and the wider community. SCOPE Managed care emerges as a product of the contemporary, neo-liberal market with which it is inextricably linked. In order to understand the nature of this concept, then, this research necessarily includes a limited account of the nature of the market in which managed care is situated and disseminated. While a more detailed examination of the neo-liberal market is worthy of a thesis in itself, this project attends, less ambitiously, to two general concerns. Firstly, against a background of various histories of health care distribution, it assesses the market's propensity for upholding the moral requirements of health care distributive decision-making. This aspect of the analysis is informed by a framework for health care morality the construction of which accompanies an inquiry into the moral nature of health care, including a deliberation about rights-claims to health care and the proper means of its distribution. Secondly, by way of offering a precautionary tale, it examines the organisational structures and regulations by which its expansionary ambitions are promoted and realised. CONCLUSIONS As a market solution to the problem of administering health care resources, the pursuit of cost-control, if not actual profit, becomes the primary objective of health care activity under managed care. Hence, the moral purposes of health care provision, as pursued within the therapeutic relationship and


In order to accelerate the weathering of paint and enamel test panels, Gardner, Davis, and Davis [1] ] exposed samples on a movable rack, instead of in a fixed position, facing south and inclined 45 from the horizontal. By means of a water wheel and daily manual adjustments the rack was kept facing the sun throughout the day. The rather considerable shortening of the testing time obtained by this method inspired the adoption of the same principle in the pres-


In a previous communication it has been shown that when labeled plasma protein is given intraperitoneally it rapidly appears in the circulation and that after 6 hours the level of activity is the same in the circulation as if an equal dose of protein had been given intravenously (1). In contrast it was also shown that the oral administration of plasma protein led to entirely different results, owing presumably to the degradation of the protein in the gastrointestinal tract. In addition, it was demonstrated that the plasma protein in the circulation rapidly came into equilibrium with some tissue or tissues which caused its breakdown, since the rate of evolution of labeled carbon dioxide reached its maximum after a period of only 2 or 3 hours. The present experiments were designed to show the rapid transfer of the labeled protein from the blood or peritoneal cavity into the lymph by the direct method of collecting lymph from the thoracic duct. Plasma protein was labeled either by feeding serine-p-U4 as before (Donors A) or by feeding killed labeled organisms to rats (Donors B). The organism used was Rhodospirillum rubrum, grown in a medium containing labeled bicarbonate until the maximum uptake had been attained.' Details of the procedure will be given in a later communication.


Nadim as the herald of a new discourse are less convincing than his choice of Mahmud Tahir Lashin to represent its maturity. From Nadim to Lashin, and incorporating many heretofore under-researched writers such as Labiba Hashim and 'A'isha Taymur, he shows the impossibility of separating aesthetic analysis from social conditions of production. He ends with a detailed study of "Hadith al-qarya" (a translation by C. Cobham is provided) weaving together the many strands that compose his own narrative. MARILYN BOOTH


The invention provides a high precision angle measurement method. Firstly, an object to be measured is arranged on a rotary platform; subsequently, a 720-tooth circular dividing table and a 391-tooth circular dividing table are combined and arranged on the rotary platform, and a plane reflector is arranged on the combination of the 720-tooth circular dividing table and the 391-tooth circular dividing table; subsequently, a photoelectric auto-collimator is adjusted so that the measurement light emitted by the photoelectric auto-collimator aims at the plane reflector; the combination of the 720-tooth circular dividing table and the 391-tooth circular dividing table is rotated by an angle; and the rotation angle is recorded; subsequently, the rotary platform is rotated reversely so that the measurement light emitted by the photoelectric auto-collimator re-aims at the same position on the plane reflector; at the moment, the rotation angle values of the 720-tooth circular dividing table and the 391-tooth circular dividing table are angles that a to-be-measured sensitive device turns. The operation steps in the method are simple, and angles all around can be tested at high precision.


Optical fibers, chemistry, lasers, and fluorescence spectroscopy have been combined to form remote fiber fluorimetry (RFF). The key to RFF is the use of fiber-optic chemical sensors (FOCSs). The RFF system has been used to measure volatile chloroorganics in groundwater and the vadose zone. This new technology provides an analytical capability where traditional systems have not been practical or feasible. FOCSs were tested in Henderson, Nevada, in wells that were known to contain chloroform. Backup analysis provided an independent reference for the in-situ measurements. 2 references, 3 figures.


Introduction: Fetal alcohol syndrome is a preventable, yet common condition caused by maternal alcohol consumption during pregnancy. There are four specific biochemical markers in the bloodstream that can help to gauge how much alcohol a mother has consumed during pregnancy. Mothers who consumed at least 29.6mL of alcohol per day, would show at least one marker and mothers who showed two or more markers gave birth to infants that were physically shorter, lighter in weight and had smaller head circumferences than children who were not prenatally exposed to alcohol ("Fetal Alcohol Syndrome", 2002). The SHH gene, also know as Sonic Hedgehog, is a chemical signal that plays a vital role in embryonic development. Sonic Hedgehog promotes cell growth, specialization, and development of parts of the body such as the brain, spinal cord, eyes and limbs. Specifically though, it plays a vital role in the development of the brain and spinal cord ("SHH", 2015). Prenatal exposure to alcohol can severely decrease the amount of sonic hedgehog transcription factors in cell populations (O'Neil, 2010). Due to the fact that sonic hedgehog plays such a vital role in spinal cord development, we predicted that chick embryos exposed to alcohol during development would have shorter body lengths than embryos that were not exposed to alcohol. The spinal cord of embryos exposed to alcohol would not be able to develop as efficiently because of the decreased amount of sonic hedgehog transcription factors. Therefore, in this study, we examined the effects of embryonic exposure to alcohol on chick embryos to test the hypothesis that embryos exposed to alcohol will, on average, develop a shorter body length than chick embryos not exposed to alcohol.


The use of permanent hair dyes exposes hairdressers to contact allergens such as p‐phenylenediamine (PPD), and the preventive measures are insufficient.


This paper focuses on the reliability of complex system that has been measured as a complex system using minimal paths. The reliability of this system has been assigned to research the possible approaches of the assignment reliability values based on reducing the total cost of this method. The results originally included: (i) Three cost functions were used to measure the cost of the complex system: First, the exponential behavior model with the feasibility factor model. Second, the exponential behavior model. Third, the logarithm model. (ii) The reliability of every component of the system was calculated using Particle Swarm algorithm to solve the problems of optimizing the given reliability of the complex system.


The synthesis and characterization of several highly ordered lanthanide complexes formed by the use of f-metal directed supramolecular synthesis is described. These unique self-assemblies or bundles are chiral as well as luminescent, where the lanthanide-based emission is observed upon excitation of the ligands (antennae) employed. These structures also give rise to chiral lanthanide luminescence (using CPL) demonstrating the chiral nature of these self-assemblies.


Predeformation parameter is essential to elevator steel wire rope's production and performance.In the process of production,adjustable horizontal predeformation device is most suitable for producing elevator ropes because of its adjusting horizontal spacing and vertical spacing of the wheel at the same time.In the process of designing perform head,cone angle,work wheel diameter and wheel groove radius etc.The design principle of predeformation parameter technology: ensure enough deformation of strand,when the strand going through the middle deformation wheel.Steel wire rope structure,stranding condition,standard and intensity,core material,etc.will effect on predeformation.Deformation rate is an objective way of judging predeformation parameter;fiber core deformation rate is controlled 82%~90%,steel core deformation rate is controlled 82%~87%.


Radars must operate in environments where interference can potentially degrade performance. With a fully digital array, classical adaptive radar signal processing methods suffer from higher order of computations and latency overhead. This is a challenging problem in the era of dynamic spectrum sharing where the interference sources can be highly variable. In this paper, we propose a fast ML-assisted method for detection of interference sources and estimation of their directions of arrival. These estimates are used for computation of adaptive weights with a covariance-based method that reduces the number of complex matrix inversion operations. Using simulation-based evaluations, we compare the results of our proposed approach with the classical methods.


.............................................................................................................................. 4 INTRODUCTION ...................................................................................................................... 6 Energy metabolism in skeletal muscle ................................................................................... 6 Dynamics of skeletal muscle lipid pools ............................................................................ 9 Metabolic flexibility of skeletal muscle ............................................................................ 10 Skeletal muscle fiber types ............................................................................................... 11 Role of peroxisome proliferator-activated receptors (PPARs) in energy metabolism in skeletal muscle ...................................................................................................................... 12 Peroxisome proliferator-activated receptor / ................................................................. 12 Exercise and energy metabolism in skeletal muscle ............................................................ 14 Skeletal muscle as a secretory organ................................................................................. 18 Insulin resistance, obesity and type 2 diabetes ..................................................................... 19 AIMS OF PRESENT STUDIES .............................................................................................. 22 SUMMARY OF PAPERS ....................................................................................................... 23 Paper I ................................................................................................................................... 23 Paper II ................................................................................................................................. 25 Paper III ................................................................................................................................ 27 Paper IV ................................................................................................................................ 29 METHODOLOGICAL CONSIDERATIONS ......................................................................... 31 Cultured skeletal muscle cells as an in vitro model .............................................................. 31 Donor characteristics ............................................................................................................ 33 Methods used to measure energy metabolism in cultured skeletal muscle cells .................. 35 DISCUSSION AND CONCLUSIONS .................................................................................... 37 Oxidative capacity and metabolic flexibility ........................................................................ 37 Fast-to-slow transformations in skeletal muscles ................................................................. 41 Lipid storage and turnover .................................................................................................... 42 Effects on insulin sensitivity ................................................................................................. 45 Final considerations .............................................................................................................. 46 REFERENCES ......................................................................................................................... 48


Ligand pKa and metal hydricity scale with one another in (de)hydrogenation catalysts that undergo metal–ligand cooperativity, irrespective of metal or ligand identity. Anionic hydrides are significantly more hydridic than their neutral counterparts.


SELECTED FAMILIES residing in Phoenix, Ariz., were studied from June 1960 through August 1961 to determine if intensive observa¬ tion would indicate the mode of introduction and familial spread of common enteric organ¬ isms. Such information had previously been sought by studying family contacts of persons acutely ill with diarrhea who were being ob¬ served in an investigation of the etiology of diarrheal diseases (1). However, the interval between onset of illness and study of the family prevented collection of definitive information. Inevitably 7 to 12 days elapsed from the onset of symptoms until medical attention was sought and pathogens were identified. Monthly sur¬ veys of populations to determine prevalence of Shigella and Salmonella and of diarrhea like¬ wise failed to provide information in sufficient detail to reveal patterns of introduction and spread of enteric organisms in families.


Fang Dongmei's life ontology was established on the basis of absorbing western life philosophy and Chinese philosophy,especially The Book of Changes and The Doctrine of Mean.In the early stage,when he absorbed Bergson and Nietzsche's life philosophy,he couldn't solve the contradiction between rationality and non-rationality,sense and sensibility.After transferring to Chinese philosophy,on the enlightenment of the theory of life and value in The Book of Changes and The Doctrine of Mean,he modified the contradictory ideas set in his early stage,and put forward universal life as his highest concept in his philosophy.What's more,he defined six elements to illustrate his concept of universal life,including principle of life,love,generation,unity,neutralization and harmony,and association,which make Fang Dongmei's life ontology have the character of organism and systemization.


Gamma logging while drilling played an important role in logging while drilling.Because it can be used for reservoir classification and evaluation of drilling ratio of reservoir in horizontal wells.Gamma logging while drilling was mainly affected by such environmental factors as size of the borehole and mud property etc.According to different environmental effects,auto-correction described in this paper was first used to read out values by discrete sampling from corresponding correction charts.Regression analysis was used to fit the reading point data so as to find out the correction formula (models) and write a corresponding correction program.A standard formula (model) is used to replace the correction chartboard for automatic environment correction of logging data while drilling gamma well logging.The results are close to the corrected wire line gamma data from logging while drilling.


We investigate a supersymmetric extension of the W3 algebra, which is common to a c=4 free fermion model and to the generic c<4 supersymmetric coset models based on at level (3, m). By using the so-called character technique, we identify a set of eight generating supercurrents of this algebra. For m=1, corresponding to c=10/7, the algebra reduces to the "minimal" super W3 algebra, which has been studied previously.


We measured the mean plane of the Kuiper Belt as a function of semimajor axis. For the classical Kuiper Belt as a whole (the nonresonant objects in the semimajor axis range 42–48 au), we find a mean plane of inclination and longitude of ascending node (in the J2000 ecliptic-equinox coordinate system), in accord with theoretical expectations of the secular effects of the known planets. With finer semimajor axis bins, we detect a statistically significant warp in the mean plane near semimajor axes 40–42 au. Linear secular theory predicts a warp near this location due to the nodal secular resonance; however, the measured mean plane for the 40.3–42 au semimajor axis bin (just outside the ) is inclined to the predicted plane, a nearly 3σ discrepancy. For the more distant Kuiper Belt objects of semimajor axes in the range 50–80 au, the expected mean plane is close to the invariable plane of the solar system, but the measured mean plane deviates greatly from this: it has inclination and longitude of ascending node . We estimate this deviation from the expected mean plane to be statistically significant at the ∼97%–99% confidence level. We discuss several possible explanations for this deviation, including the possibility that a relatively close-in ( au), unseen, small planetary-mass object in the outer solar system is responsible for the warping.


The demand for mapping the buried cables is increasing dramatically with the rapid expansion of urban area, but there are few specific procedures and approaches to map underground cables without disturbing the normal electricity supply. In this letter, a cable-mapping approach based on the ground-penetrating radar (GPR) is proposed, which consists of two parts. First, the parallel scan lines are established along which the GPR is moved to obtain the B-scan images; the hyperbolic shapes on these obtained images are identified and fitted; and the locations and depths of the detected sample points of the buried cables could be derived from these hyperbolas. Then, due to different terrain and surrounding obstacles, as well as the use of pipe-jacking technology,1 the underground cables may not be straight. The detected points are interpolated by a three-dimensional spline interpolation algorithm to obtain a smooth 3-D curve with location and depth information. Compared with the 2-D model, the 3-D curve could visualize the direction of buried cables more intuitively. Also, in comparison with other interpolation algorithms, the error caused by the proposed interpolation is minimized on the chosen data sets. Experiments on real-world data sets are conducted, and the obtained results demonstrate the effectiveness of the proposed model.1Pipe-jacking is a trenchless technology for buried utilities [1].


The paper puts forward the model for radar type recognition in data fusion.Relational analysis method is used to recognize radar type,and evidence theory is used to fuse the data in the different time field.These two methods are combined effectively in the paper.The result of recognition illuminates that this model can efficiently improve the recognition rate,the reliability and the ability of fault tolerance in the strong noise environment.


This project forms part of a wider research interest in the sensory qualities and embodied experiences of historic buildings and places. As part of the Much Ado About Portsmouth festival in April, an interdisciplinary group of students worked at the manor to produce installations, photographs, creative writing and soundscapes.


ii results have demonstrated that the ballistic transport in DG MOSFETs is enhanced due to channel length (Lch) scaling until Lch = 10 nm, but when Lch is further scaled to less than 10 nm, SR scattering intensified by spatial fluctuation of quantized subbands drastically degrades ballistic transport. The results indicate that performance improvement is difficult even if MOSFETs are scaled less than 10 nm, which is very important viewpoint for the discussion of the miniaturization limits. Next, a quantum-mechanics-based MC simulator is developed for rigorously incorporating quantum transport effect along the source-to-drain direction. The simulator is based on Wigner transport equation (WTE) and the method is called 'Wigner Monte Carlo (WMC)' simulator. WMC method solves WTE using MC algorithm and incorporates not only scattering effects but also quantum transport effects more precisely. Therefore, the method is thought to have the ability suitable for the simulation of integrated nanoscale devices. This study is the first successful attempt of WMC simulation in Asia. Furthermore, the WMC quantum simulation method is extended to multi-subband (MS) simulation and effects of quantum transport effects in silicon DG MOSFETs with channel length of less than 10 nm are investigated. As a result, it is demonstrated that the quantum reflection makes significant differences in the microscopic features of electron transport and can even reduce the drain current at on-state. On the other hand, SD tunneling is shown to play a crucial role in the subthreshold properties of scaled MOSFETs with channel lengths of less than 6 nm. Finally, in order to demonstrate the applicability of WMC method to new channel material MOSFETs, III–V channel MOSFETs are simulated. III–V compound semiconductors are expected to replace Si as the channel material in n-channel MOSFETs because of their lower transport effective mass and higher electron mobility than Si. Therefore, treatments of conduction band structure in III-V MOSFETs and polar optical phonon scattering, which is intrinsic to the compound semiconductor materials, are described, and the treatments are incorporated to WMC simulator in order to investigate the impact of SD direct tunneling in III–V channel MOSFETs with In0.53Ga0.47As and InP. As a result, it was found that subthreshold current increase due to SD direct tunneling becomes more remarkable in both In0.53Ga0.47As and InP MOSFETs, owing to its considerably lower effective mass compared to Si. In addition, the critical channel length for which a drastic increase in subthreshold current occurs due to SD direct tunneling was found to be about 20 nm for both In0.53Ga0.47As and InP MOSFETs. Since this value is significantly larger than that for Si MOSFET, SD direct tunneling can be a major obstacle to downscale III-V MOSFETs into Lch < 20 nm. Hence, to go beyond the end of the roadmap, we will need a material selection for suppressing SD direct tunneling while maintaining the high current drivability. We suggested that the choice of a material with a heavier transport mass might be one option.


Breast cancer is a pressing non-communicable disease, especially affecting women, with its incidence on the rise. In 2020, it ranked among the most common cancers in Indonesia. Timely detection and precise diagnosis are pivotal for effective breast cancer management. To enhance diagnostic accuracy, the K-means clustering method is applied to group patients based on shared attributes. This research aims to contribute significantly to breast cancer diagnosis by leveraging the K-means method, potentially improving patient survival rates.The research process involves data collection, preprocessing, K-means application, evaluation, and visualization. A dataset of 569 breast cancer patient records with 32 attributes from Kaggle is utilized. The K-Means algorithm is assessed using accuracy, yielding a value of 0.8457, signifying good performance. Malignant cases (211) and benign cases (301) are visualized in a scatter plot, distinguishing between them.In conclusion, this study presents an initial step in utilizing the K-means algorithm for breast cancer diagnosis, offering promising results. Further research and the development of more advanced models are imperative to address the global health challenge posed by breast cancer among women.Index Terms—breast cancer; clustering; K-Means Algorithm


An apparatus (1405) fluid dispenser to accommodate a device (1408) fluid discharge, comprendiendoel dispenser fluid a body (1409) defining a cavity, and a nozzle (1411) dispensing quetiene one dispensing orifice, characterized by the provision of a cap (1407) terminal protective having: an inner surface for engagement with the body, and an inner portion having an annular wall defining a cavity in which a plug (1460) is alojadocomo an insert caperuzara the same, in which the insert cap comprises a flat base and a portion (1461) upper convex and said planaesta base shaped to be received by said cavity so that the convex top faces haciafuera, wherein the cap terminal is movable from a first position in which it covers the nozzle to a second nozzle positioned which is exposed, and wherein the stopper is located on the end cap so that when the end cap is in laprimera position, the convex upper stopper portion is in contact with the dispensing nozzle to seal elorificio the dispensing nozzle and in the second position the stopper is separated from the dispensing nozzle.


Three palladium (II) complexes with the isonitrosobenzoylacetoneimine (HIBI) ligand, Pd (p-CH3C6H4IBI)2 (1), Pd (C6H5IBI)2 (2) and Pd2Cl2 (C6H5CH2IBI)2 · CHCl3 (3), were prepared and characterized by IR, Raman and X-ray diffraction studies. The geometries around the palladium atoms in the complexes 1 and 2 are distorted trans-PdN4 square planes, and the Schiff base ligands RIBI− are coordinated through their oximo-nitrogen atoms and imino-nitrogen atoms. The week Pd…HC agostic interactions [Pd…H = 0.2764 nm] complete the hexacoordinate environment around palladium in the complex 1. The octahedral deformation of the classical square planar environment of the Pd atom is due to the week Pd…O (1b) interactions [PdO (1b) = 0.3157 (9) nm] in the complex 2. The complex 3 is a first example of binuclear complex with isonitrosoketoimine ligands, in which one of oximo groups is coordinated through oximo-nitrogen and oximo-oxygen atoms.


In this paper we search for the location of a facility in a city that minimizes the total transportation cost. We consider goods to be transported from supplier locations outside the city to the facility and from the facility to customer locations in the city. We model the city as a disc with radius R and we assume the population density and customer location density at a distance r from the city centre to be proportional to exp(-γr) with γ a real number. Furthermore we assume that all supplier vehicles enter the city at the same point. We calculate the total cost of the customers and suppliers transportation in the city in function of the facility location and we prove three theorems about the optimal facility location. One of these theorems enables us to find the optimal location numerically. We also present graphs of the optimal location in function of an introduced parameter for different values of γR.


We constructed the low-coverage Porphyra yezoensis draft genome using the Solexa high-throughput sequencing system.The predicted genome size was approximately 220 Mbp,with the GC content of 53.09%.The draft genome contained 26 629 predicted protein-coding genes,16 409 of which had introns,averagely 2.22 introns per gene.Gene structure analysis of intron-containing genes showed that the average gene size and intron size was 2214 bp and 319 bp,respectively.Metabolic pathway analysis indicated that the purine metabolism was the largest pathway.The P.yezoensis draft genome constructed in this study manifested important genomic properties such as genome size and the gene structure of protein-coding gene,proving the feasibility of Solexa high-throughput system in sequencing the whole genome of P.yezoensis.


We consider an infinite-horizon in problem with stochastic demands where the data vary periodically. Karlin Karlin, S. 1960a. Dynamic inventory policy with varying stochastic demands. Management Sci.6 231-258; Karlin, S. 1960b. Optimal policy for dynamic inventory process with stochastic demands subject to seasonal variations. J. SIAM8 611-629. shows that a periodic critical-number policy is optimal and presents an algorithm for computing the critical numbers, assuming discounted costs. Here we develop an alternative, conceptually simpler approach to these problems. The results include a proof of the optimality of such policies for the average-cost case, and a qualitative description of the behavior of the optimal policy as "smoothing" fluctuations in the data.


Due to the climatic conditions in the Central European countries road pavement structure should be water and frost resistant. This problem is especially important for pavements rehabilitated with the cold recycling technology. The aim of the research project was to determine the impact of foamed bitumen and bitumen emulsion content on the physical and mechanical properties of the base course with the cold recycling technology and to determine its water and frost resistance. The bitumen binder was added to the recycled material in the amount of 2.0% to 3.5 % with changes every 0,5%, and hydraulic binder (cement) of 1.0%. The test showed that the application of foamed bitumen in the base course materials results in an improvement its mechanical properties (Marshall stability and stiffness, static creep modulus and indirect tensile strength) in comparison to bitumen emulsion. The measurements of water and frost resistance (according to AASHTO T283) and the resistance to low temperature cracking (according to PANK 4303) have showed that the use of foamed bitumen results in higher resistance to these climatic factors than in case of the application of the bitumen emulsion as a binder in the cold base course mixes.


In order to localize itself a mobile robot tries to match its sensory information at any instant against a prior environment model, the map. A probabilistic map can be regarded as a model that stores at each robot configuration q the probability density function of the sensor readings at q. By combining the knowledge of its current position, the new-coming sensory information, and the probabilistic map the robot is capable of improving its prior position estimate. In this paper we propose a novel sensor model and a method for maintaining a probabilistic map in cases of dynamic environments. When the environment structure changes, the map must adapt to this change by modifying the sensor densities, at the respective configurations. We propose a combined algorithm for map update and robot localization.