ABSTRACT The role of the press as a political watchdog is crucial to the functioning of democracy. Especially in the run-up to elections, voters depend on the media's presentation of parties and candidates to make informed, responsible choices at the ballot box. But who, then, influences the news media? Empirical evidence in the United States and Europe suggests that political party campaigns and election coverage in the news media are interconnected and influence each other. This study tests whether such agenda-setting effects between party campaigns and the media also take place in the general elections in the world's largest democracy, India. India's western-type political system has a distinct media system characterized by high competition, diversification, non-consolidation and formal and informal ties between the media, commercial interests and political actors. Content analysis and Granger's causality test of newspaper coverage (N = 716) and party campaign messages (N = 458) found that agenda-setting effects do occur in India, but are largely bi-directional. We also found an overwhelming focus of both newspapers' election coverage and of all major party campaigns on one single candidate, the Bharatiya Janata Party (BJP)'s Narendra Modi. This, we argue, is a result of the broader trends that have shaped Indian politics in recent years. The significant correlations and non-significant causal effects between party campaign and media coverage also indicate a trade-off situation between political power negotiation and political balance in the press.


Wafer Plane Inspection (WPI) is an inspection mode on the KLA-Tencor TeraScaTM platform that uses the high signalto- noise ratio images from the high numerical aperture microscope, and then models the entire lithographic process to enable defect detection on the wafer plane[1]. This technology meets the needs of some advanced mask manufacturers to identify the lithographically-significant defects while ignoring the other non-lithographically-significant defects. WPI accomplishes this goal by performing defect detection based on a modeled image of how the mask features would actually print in the photoresist. There are several advantages to this approach: (1) the high fidelity of the images provide a sensitivity advantage over competing approaches; (2) the ability to perform defect detection on the wafer plane allows one to only see those defects that have a printing impact on the wafer; (3) the use of modeling on the lithographic portion of the flow enables unprecedented flexibility to support arbitrary illumination profiles, process-window inspection in unit time, and combination modes to find both printing and non-printing defects. WPI is proving to be a valuable addition to the KLA-Tencor detection algorithm suite. The modeling portion of WPI uses a single resist threshold as the final step in the processing. This has been shown to be adequate on several advanced customer layers, but is not ideal for all layers. Actual resist chemistry has complicated processes including acid and base-diffusion and quench that are not consistently well-modeled with a single resist threshold. We have considered the use of an advanced resist model for WPI, but rejected it because the burdensome requirements for the calibration of the model were not practical for reticle inspection. This paper describes an alternative approach that allows for a "soft" resist threshold to be applied that provides a more robust solution for the most challenging processes. This approach is just finishing beta testing with a customer developing advanced node designs.


A the beginning of May 2002, the Joint Committee of the Nordic Psychiatric Associations met in Stockholm in connection with the 11th Congress of the Association of European Psychiatrists. As the Baltic countries were represented, the meeting also covered aspects related to the North European Zone of the World Psychiatric Association. It is obvious that the historical bonds and the cultural similarities between the Nordic countries still engender strong fellowship, and there is undoubtedly an important role for the Joint Committee of the Nordic Psychiatric Associations. The Committee was therefore able to plan the next Nordic Psychiatric Congress in Reykjavik on 13–16 August 2003 conŽ dent that the members of the National Associations will take the opportunity to meet and share experiences and knowledge. This will be the 27th Nordic Psychiatric Congress, illustrating the long-standing,  ourishing cooperation between the Ž ve Nordic countries. It is also obvious that there is still a place for the Nordic Journal of Psychiatry as a vehicle by which the members of the Nordic Psychiatric Associations can publish their scientiŽ c reports and share experiences. It is also important that the Journal is covered by all the most salient databases. Through the journal, the results of the Nordic authors will be read and noticed across the world. However, it is also obvious that a broader international cooperation is of importance. Together with the three Baltic states, the Ž ve Nordic states form the North European Zone of the World Psychiatric Association. Today, the Nordic Journal of Psychiatry reaches members of the Associations in the eight countries of the North European Zone, with a circulation of 6,000 copies. However, there is also increasing interest in taking responsibility within the European cooperation. Sweden, Denmark and Finland have entered the European Union and the Baltic states are on their way. Finland has joined the monetary union and the Finnish Treasurer of the Joint Committee has suggested that all fees to the Committee should be paid in Euros, which are now being used in Finland and possibly in the other Nordic and Baltic countries in the future. There is also increasing interest in cooperation within the Association of European Psychiatrists (AEP). The European cooperation is more recent than the Nordic cooperation, the next Nordic Congress being the 27th, whereas the next European Congress will be the 12th. The AEP is still a comparatively small organization. With the Joint Committee of the Nordic Psychiatric Associations numbering more than 5,000 members, the AEP still has only 1,000–2,000 members. In the future, the European Congresses might be an interesting forum also for the members of the Ž ve Nordic and three Baltic states, and the journal of the AEP, European Psychiatry, might be strengthened to become a real alternative to the American Journal of Psychiatry.


Magnetohydrodynamic (MHD) flow of fluids with porous media has several applications in medical and industrial fields, including hyperthermia, wound treatment using magnetic field, cancer treatment, heat exchangers, catalytic reactions and distillation towers. In the present work, we explored the two-phase flow of MHD Jeffrey fluid in the presence of porous media through horizontal walls. The uniform liquid properties and magnetic field effects are also considered in this investigation. The heat and mass transfer effects on fluid flow with the addition of Hafnium metallic particles are evaluated. The governing nonlinear momentum and energy equations are found by using Jeffrey's stress tensor. We discussed three types of flows, namely, Plane Poiseuille, Plane Couette, and Generalized Couette. The effects of all involved parameters on flow and temperature distributions are deliberated with graphs for all cases separately. The results interpreted that increase in values of Darcy number upsurges the velocity and temperature distributions. Radiation parameter declined the temperature of fluid while Brinkman number enhances temperature in all types of flow. Comparison of Newtonian and non-Newtonian fluid is also presented in this study, and we also validated our results by comparing them with the already existing literature results.


1.5 million students, representing 21.5% of the 19 to 26 year old age-group (1989) (Statistisches Bundesamt, 1990); 243 institutions, 68 of which are universities, and 122 are the more vocational and less research-oriented so-called Fachhochschulen (residuum: arts colleges, teacher training colleges, theological colleges) (BBW, 1989, p. 146); 11 states (Lander) in the Federal Republic of Germany, financing and governing higher education within their respective borders; the federal government, with the Federal Minister of Education and Science, financing 50% of the investments in higher education, being responsible for student aid, having framework competencies in German higher education; the Science Council (Wissenschaftstrat), an advisory 'buffer body' in German higher education, consisting of both state and higher education members, delivering recommendations on the most pressing problems in German higher education; the Conference of Rectors and Presidents ( Westdeutsche Rektorenkonferenz: WRK), representing the common concerns of German higher education institutions to the public, the politicians and the governments. Apart from these actors and figures there is another frame of reference to be taken into account when talking of German higher education: the attempt to interpret the traditions and the heritage of German higher education: (i) German higher education is publicly financed within a federal system. It is free


In 2009, FSS carried out a qualitative study o f the state, causes and im pact o f household food insecurity, as well as their coping m echanism s, using the case o f Lideta Sub-city in Addis Ababa. The study found that food consum ption am ong the poor households that it covered had declined to very low levels over the last several years. The food consum ption for an average individual am ounted to one piece o f bread per individual or even nothing for breakfast, h a lf an injera w ith shi.ro o f variable quality or some qollo for lunch and the same for dinner. The causes o f the decline in the am ount and quality food consum ption include rises in the price o f food and other basic com m odities, losses o f jo b s or incom e sources, pre-existing poverty and unem ploym ent, contraction o f dem and for the goods and services o f the poor, and households' decision to invest in the schooling o f a family m em ber. The m ost im m ediate outcom e o f household food shortages is chronic hunger; o ther impacts include physical weakness, em otional distress, w eight loss, illness, and lower educational and work perform ance. H ouseholds' coping m echanism s include reducing the am ount and quality o f dietary item s, engaging in incom e generating activities and dependency on several incom e earners. The study recom m ends adopting an urban food security strategy w ith a safety net program me; im proving the grain subsidy program m e; strengthening C onsum ers Cooperatives; prom oting em ploym ent; expanding com m ercial and urban food production and processing; and im proving child nutrition.


Many of the claims about the benefits of individual contracts ride on the proposition that individual contracts deliver higher productivity (BCA 2005:12; ACCI 2004:1; Langoulant 2004; Andrews 2004b; OEA 2004a; Gollan & Hamberger 2003; Howard & Andrews 2005:3). When productivity is higher, the corporation can afford to pay more and is more than willing to do so. Individual contracts, therefore, are a 'win win' for both corporation and employee. It is on this basis that public policy changes since 1996 have sought to discourage union-related collective bargaining and promote individual contracting. This paper seeks to assess the claims of corporate lobbyists and the Federal government that individual contracting raises productivity. It compares the effects on productivity of individual contracting and union-related collective bargaining. It also refers to comparison between the effects of individual contracting and of awards on productivity growth. It starts by looking at national level evidence in New Zealand (where a system of individual contracts was abruptly introduced in 1991) and Australia (where individual contracts have been encouraged in the federal jurisdiction since 1997), then turns to closely examine the basis of the evidence put forward by the Business Council of Australia (BCA) and, more recently, the federal government. It also considers the argument that encouragement of individual contracting will help solve the current skills shortage, and the relationship between contracting and profitability.


The results of long-term research on the use of drained lowland peat and developed soils in feed production in the North-East of the European part of Russia are presented. The main agroecological technologies for the production of high-quality feed in soil-protective crop rotations, long-term pastures on drained low-lying peat soils and methods for using developed peatlands in intensive haymaking mode are proposed.


In plasmas immersed in the toroidal field Bφ, electrons drift downward while ions drift upward due to the field gradient and curvature (Bφ > 0 is assumed). The plasma is usually bounded at the top and bottom by the conducting vessel walls. The same amount of current must flow into and out from the walls at the top and bottom, respectively, to complete the current circulation via the vacuum vessel. In an ECR plasma in the LATE device radial profiles of vertical charge separation currents have been for the first time measured by radially aligned multi-electrodes fabricated at the top and bottom. Both the profiles at the top and bottom are nearly the same as the profile 2Pe/RBφ in the plasma as theoretically predicted. Current characteristics upon the sweep of external voltage onto the top ion collectors reveal that the current is due to inflow of ions with no secondary electron emission. c © 2012 The Japan Society of Plasma Science and Nuclear Fusion Research


In the light of increasing awareness of the importance of controlling the damage in seismic design, it is now well known that a paramount role should be given to deformation quantities in earthquake resistant design. As a result the traditional force-based strategy has been questioned and consequently displacement-based strategy has been suggested during the past decade. While the actual impact of displacement-based design strategy on seismic design practice has yet to be explored, clear advantage can be expected by using current advancement in computational tools to quantify and control the deformation demands within the structure.


Objective: To evaluate the net clinical benefit of a reduced dose of direct oral anticoagulants (DOACs) compared to warfarin in nonvalvular atrial fibrillation. Design and method: We searched three electronic databases covering the period until end-February 2021. All-cause death, non-fatal stroke/systemic embolism, and major bleeding events, with or without the inclusion of myocardial infarction, were used to define two different net clinical benefit outcomes. In addition, we evaluated different component outcomes of net clinical benefit as secondary outcomes. Finally, each outcome's risk ratios and 95% Confidence Intervals (CI) were calculated (random-effects model). Results: In the four randomized trials included (n = 29,779 patients), the net clinical benefit - with or without the inclusion of myocardial infarction - of low-dose DOACs, compared to warfarin, was a 12% (95% CI, 7%-16%) or a 10% (95% CI, 5%-13%) reduction of events, respectively. Compared to warfarin, the reduced dose of DOACs decreased death outcomes, major bleeding events, and hemorrhagic stroke, whereas all thrombotic outcomes were not different among the groups. Conclusions: DOACs at low doses present a more favorable net clinical benefit profile than warfarin.


Purpose In order to discuss the operating room to control the hospital infection the management countermeasure, pays special attention to the operating room disinfection isolation work.Method Establishment perfect management and surveillance systems; Strengthens all levels of personnel to train educates again; Find out the insufficiency through each kind of monitor, Looks for the reason. Carries on analyzes and reorganizes with the summary. Result Formulated the operating room to control the hospital infection countermeasure, caused each target in the normal range. Conclu- sion Only then the establishment and the perfect each management link, strengthen training to educate again can deepen to controls the hospital infection work the understanding, enhances the operating room the infection management level.


In this paper, an image-based humanoid robot pose recognition system is designed and implemented to recognize humanoid robot pose and some objects position in the field. Robot Operating System (ROS) is used to establish the software development framework for the image recognition system. The image recognition system includes feature matching, region of interest (ROI) capture, background subtraction, edge detection, and object segmentation. Then the Inverse Perspective Mapping (IPM) is used to determine the location of humanoid robot and some objects. Experimental results show that the proposed robot pose recognition system can simultaneously recognize and track both of obstacle, humanoid robot and its pose.


The Free State Department ofAgriculture distributed food security packages to Qwaqwa households in 2003. The purpose of distributing food security packages was to improve the food security status of poor households. Thirty households received food security packages to the value ofR4500.00 each between March and May 2003. The packages were designed to include: garden fencing materials, gardening tools, winter and summer seeds, fertiliser, water hoses, twenty village chickens, chicken feed and a portable, ready made poultry cage. This study sets out to evaluate the impact ofthese packages distributed by the Department of Agriculture to Qwaqwa households by comparing dietary diversity, frequency ofconsumption, income sources, coping strategy applications and food security status. Maxwell et al 's (2003) Coping Strategy Index (CSI) was used to determine relative food security status. Data on household demographics, food consumption patterns and consumption coping strategies was collected from 30 recipient households and 30 nonrecipient households whose names were on the waiting list for food security packages in Qwaqwa. The results of the. study showed that the packages improved food security in recipient households. First, the frequency of consumption of most foods included in packages (carrot, beetroot, eggs as by-product of chicken and chicken) was higher among recipient households. Food consumption patterns improved in recipient households as more households diversified food intake. Second, some coping strategies applied by recipient and non-recipient households were similar, but the frequency of application of these strategies differed between households in the two groups. The frequency ofapplication of


Abstract Disclosure: C. Alcorn: None. P. Subarajan: None. S. Ghaith: None. K. Jordan: None. Introduction: Megestrol, a progestin derivative, is a common drug used for anorexia or cachexia. Chronic use of megestrol can lead to suppression of the pituitary-adrenal axis, causing secondary adrenal insufficiency (SAI). Case: A 93-year-old female with a history of dementia presented with one-week history of confusion and weakness. She was found to have hyponatremia with a sodium of 134meq, consistent with her baseline. CT head and infectious workup were negative. She received 600cc of normal saline and repeat sodium decreased to 124meq/l. Nephrology was consulted due to concern for SIADH. She remained altered and was given a short course of hypertonic saline, 25cc for 4 hours. Repeat sodium after hypertonic saline was 118meq/l. TSH was normal but 8 am cortisol was 1.3 mcg/dL and ACTH level was <1.5 pg/ml. Endocrinology was consulted for evaluation of adrenal insufficiency. Cosyntropin stimulation test was performed with inadequate response, consistent with secondary adrenal insufficiency (SAI). The patient was subsequently given 50mg IV hydrocortisone with improvement in sodium to 125meq/l. The patient had been prescribed megestrol 200mg at home for cachexia. Upon discussion with her family, she was receiving multiple extra doses of megestrol per day for further appetite stimulation. She was only started on 200mg daily dose on admission. It was determined the patient had SAI secondary to megestrol use. This medication was discontinued, and she was initiated on hydrocortisone therapy with endocrinology follow-up. Conclusion: SAI is defined by deficiency of ACTH in setting of hypocortisolemia. SAI is often associated with prolonged glucocorticoid use but can also be seen in patients with pituitary tumors, pituitary surgery, or granulomatous disease. SAI can cause hyponatremia, hypoglycemia, and fatigue but is not typically associated with hypotension or hyperkalemia as the mineralocorticoid function of the adrenals remains intact. Though rare, there have been case reports of patients developing SAI while taking megestrol. Megestrol acts as a progestin and is used for appetite stimulation in patients with cachexia. Megestrol is believed to have cross-affinity for glucocorticoid receptors which leads to suppression of the pituitary-adrenal axis. This suppression leads to decreased ACTH production, inducing SAI. In this case, the patient was receiving higher than prescribed doses of megestrol at home. When her dose was reduced on admission it precipitated her adrenal insufficiency, accounting for the worsening of her hyponatremia. Identification of SAI in patients taking megestrol is imperative as early recognition and diagnosis can prevent severe complications such as adrenal crisis. These patients should have megestrol discontinued and be placed on appropriate hydrocortisone therapy. Close follow-up is required as it can take 2-3 months for pituitary-adrenal axis recovery. Presentation: Saturday, June 17, 2023


Abstract Article submissions to The Gerontological Society of America's high impact scientific journals continue to increase each year which has led to editors becoming more selective about which articles are accepted for publication. The purpose of this session is to describe how to efficiently and successfully navigate the process of determining which journal is the best fit for your manuscript. Objectives of the workshop include guidance in: (1) understanding the differences in scope and features of each journal; (2) determining which journal is most appropriate for the topic and methods of your manuscript; (3) appreciating how to use journals' Instructions to Authors to your benefit, and (3) conveying the scientific contribution of your article to the journal.


BACKGROUND
Cognitive disorders have been described in amyotrophic lateral sclerosis, but usually after the diagnosis has ben established.

CASE REPORT
A 57-year-old man was intubated for acute respiratory distress subsequent to pneumonia and diaphragm palsy. He had a 2-year history of drug-resistant depression and deterioration of cognitive functions. A pyramidal syndrome associated with biopsy-proven chronic neurogenic atrophy led to the diagnosis of amyotrophic lateral sclerosis. The electromyogram did not contribute to diagnosis. Brain MRI only evidenced moderate bilateral frontal-temporal atrophy. Brain SPECT demonstrated major perfusion defects in the frontal lobes.

DISCUSSION
This patient had amyotrophic lateral sclerosis and frontal-temporal dementia with an unusually late onset clinical presentation: cognitive disorder was the inaugural sign. Brain SPECT and muscle biopsy enabled us to identify the cortical and peripheral motor neurone involvement in this uncooperative intensive care patient totally dependent on mechanical ventilation.


Small and Medium Enterprises are expected to play a vital and vibrant role in the economic growth and development of Nigeria. Given the volatility of the Nigerian business environment, this paper ex-ray the operations of SMEs with a view to identifying challenges encountered in fulfillment of their expected roles. Several literatures on SMEs were reviewed along with a survey research design that sampled a   total of one hundred and thirty-eight (138) respondents by means of self-completed questionnaire; selected from four strategic locations in Lagos State. Data  were collected on possible issues affecting the operations of SMEs ranging from high borrowing rates, high loan requirements, government when making policy, documentation, collateral, entrepreneurial skills, business strategy to Infrastructural inadequacies. The data were analysed using the descriptive and inferential statistical tools. Result on challenges affecting SMEs operation was rated. The analysis of variances was applied to hypothesis testing. The result revealed that SMEs are constrained by inadequate funding and poor management. It was recommended that government should develop a lasting solution to the state of infrastructural deterioration especially electricity along with policies that can assist to cushion the bureaucracy in obtaining loans from micro finance banks.  Article visualizations:


The proximity of our Galaxy's center presents a unique opportunity to study a galactic nucleus with orders of magnitude higher spatial resolution than can be brought to bear on any other galaxy. After more than a decade of diffraction-limited imaging on large ground-based telescopes, the case for a supermassive black hole at the Galactic center has gone from a possibility to a certainty, thanks to measurements of individual stellar orbits. The rapidity with which these stars move on small-scale orbits indicates a source of tremendous gravity and provides the best evidence that supermassive black holes do exist in the Universe. This work was made possible through the use of speckle imaging techniques, which corrects for the blurring effects of the earth's atmosphere in post-processing and allowed the first diffraction-limited images to be produced with these large ground-based telescopes.


The purpose of this paper is to present an e[xtension and alternative of the hybrid method based on Saaty's Analytical Hierarchy Process and Technique for Order Preference by Similarity to Ideal Solution method (AHP-TOPSIS), that based on the AHP and its use of pairwise comparisons, to a new method called α -D MCDM-TOPSIS( α -Discounting Method for multicriteria decision making-TOPSIS).


This study scientifically measures the dynamic gait characteristics and energy cost of six male below-knee amputees, three vascular and three traumatic, while wearing SACH, single axis and multiple axis prosthetic feet via six-camera motion analysis, metabolic measurement cart and heavy-duty treadmill. Subjective results are additionally determined via questionnaire after testing. Motion analysis showed statistically significant differences at p < 0.05 between the solid ankle cushion heel (SACH), single axis and multiple axis foot in the velocity, cadence, stride length end gait cycle. Significant differences were found in energy cost among the prosthetic feet tested, and significant changes in walking under different speeds and different inclines. Results provide quantitative and qualitative information about the dynamic performance of the various feet which can be helpful in prescribing the optimal prosthetic foot for individual amputees.


The risk of cardiovascular diseases and sleep-disordered breathing increases after menopause. This cross-sectional study focuses on overnight transcutaneous carbon dioxide (TcCO2) measurements and their power to predict changes in the early markers of cardiovascular and metabolic diseases. The endothelial function of the brachial artery, the intima-media thickness of the carotid artery, blood pressure, glycosylated hemoglobin A1C and plasma levels of cholesterols and triglycerides were used as markers of cardiovascular and metabolic diseases. The study subjects consisted of healthy premenopausal women of 46 years of age and postmenopausal women of 56 years of age. From wakefulness to sleep, the TcCO2 levels increased more in postmenopausal women than in premenopausal women. In estrogen-users the increase in TcCO2 levels was even more pronounced than in other postmenopausal women. From the dynamic behaviour of the nocturnal TcCO2 signal, several important features were detected. These TcCO2 features had a remarkable role in the prediction of endothelial dysfunction and thickening of the carotid wall in healthy premenopausal women. In addition, these TcCO2 features were linked with blood pressure, lipid profile and glucose balance in postmenopausal women. The nocturnal TcCO2 profile seems to contain significant information, which is associated with early changes in cardiovascular diseases in middle-aged women. TcCO2 might not only measure the tissue carbon dioxide levels, but the TcCO2 signal variation may also reflect peripheral vasodynamic events caused by increased sympathetic activity during sleep.


Rotator cuff tears are the most common source of shoulder pain. Many factors can be considered to choose the right surgical treatment procedure. The most important factors are tear thickness (partial vs. full), tear size, tear shape, and muscle quality. The aim of this work was the fully automated quantification and classification of a full-thickness posterosuperior rotator cuff tear from MR images using a deep learning based approach. A complete new approach to automatically quantify and classify a rotator cuff tear, based on the segmentation of the tear from MR images, was developed and validated. A neural network was trained to segment the rotator cuff tear from an MR image and automatic methods for calculating tear width and retraction and for classifying the tear according to pattern, extension and retraction were implemented. The accuracy of the automatic segmentation and the automated tear analysis were evaluated relative to the ground truth of manual segmentations by a clinical expert, and analyzed based on the ground truth segmentations. Variance in the manual segmentations was assessed in a interrater variability study of two clinical experts. The error of the automatic segmentation to one of the two clinical experts are meant to be in the same region. To make quantification accessible the whole pipeline was implemented in an existing webapp. The results were also evaluated clinically by intraoperative measurements of the rotator cuff tear performed on a separate dataset of six patients. The accuracy of the tear retraction calculation based on the developed automatic tear segmentation was 6.56 mm ± 6.48 mm in comparison to the interrater variability of tear retraction calculation based on manual segmentations of 3.77 mm ± 3.58 mm. These results show that an automatic quantification of a rotator cuff tear is possible. The achieved accuracies of the quantification pipeline for rotator cuff tears need to be improved to make them clinically useable. The large interrater variability of manual segmentation based measurements, highlights the difficulty of the tear segmentations task in general. To improve the accuracy of an automated segmentation, a larger dataset for training may be required or a semi-automatic approach could be used.


An effective way to accommodate the computing demands of Internet-of-Things (IoT) end-user devices without the intervention of a remote server, is to motivate the collaboration between them. The latter paradigm, termed as collaborative Mobile Edge Computing (MEC), allows an end-user device to act as service provider, by allocating excess computing resources for the computation of a service requester's task, in exchange for adequate economic incentives. In this paper, we introduce a contract theory-based one-shot auction to model the computing resource trading between a service requester and the prospective service providers. Unlike existing works, we aim to account for the different types of asymmetric information arising during and after the contracting phase between the trading parties, regarding the service providers' willingness to collaborate and their offered computing power. The service requester derives a set of optimal economic bids, having statistical knowledge of the providers' private information, and each service provider autonomously selects the bid and its computing resource allocation that maximize its utility. The economic bid comprises a two-stage payment to secure the provider's truthful collaboration both prior and after the contractual agreement. The effectiveness of the proposed model is validated by comparison against benchmark contract theory models that unilaterally account for the providers' private information either prior/during or after the contracting phase.


Abstract RECENTLY wheat germ oil has been advertised as a desirable addition to the ration for the poultry breeding flock. Consequently many poultrymen are asking if it is necessary or desirable to add this material to their rations. Card (1929) reported no improvement in fertility or hatchability when 2 percent wheat germ oil was added to a mixed grain ration. Card, Mitchell, and Hamilton (1930) working with pullets that had been fed rations treated with an etheral solution of ferric chloride to destroy vitamin E showed that there was an immediate and marked improvement in hatchability when one-half cubic centimeter of wheat germ oil per hen per day was fed. The authors state "Although these results are of considerable scientific interest it should be pointed out that from a practical feeding standpoint there is little cause for concern with regard to possible vitamin E deficient rations because all whole grains and . . .


In 2020, the world has faced a new global challenge in the form of the COVID-19 coronavirus pandemic. The crisis has become a defining check-test for the Russian economy. The Russian Federation government' response was a number of measures to reduce the fast spread of coronavirus in the country, including borders closure, ban on public events, self-isolation regime introduction, educational and commercial activities transfer to virtual space and suspension of certain companies' activities. This has led not only to a number of changes in the consumer behaviour model, but also to the national digital services market boom. The digital trade segment accelerated the most, which stems from the specifics of such organizations. For a consumer the opportunity to buy goods and services on the Internet has become a key factor in ensuring a comfortable life in self-isolation. It is the retail field, which aims at meeting the basic needs of the population, and is integrated into the human life to the maximum. For retailers, in its turn, transition to the Internet and digital commerce development resulted not only in a certain volume of sales, but also in the increased competitiveness level. The given research considers the national digital services market development trends under the crisis. The paper analyses studies of the coronavirus pandemic impact on digital services development and provides the authors' approach to the "national digital services market" category. A retrospective analysis of the digital trade segment development and its current state gave insights into a number of recommendations for the national digital services market development in the near future.


A field experiment was conducted at the experimental field of the Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur under wet land condition during Boro season to find out the appropriate combination of population density and nitrogen fertilization for proper growth and yield of BRRI dhan29. The rice cultivars differed considerably in terms of crop growth characteristics as well as yield. The growth of BRRI dhan29 proceeded slowly at the beginning and the rate increased over time with new foliage being added. From 30 DAT CGR increased almost linearly up to 105 DAT; thereafter a sharp decline was noticed in all the treatments. Functional relationships between grain yield and plant factors have been established. CGR, RGR and NAR responded well to high N dose, higher number of its split and high population density. The experiment also revealed that the highest nitrogen use efficiency was obtained from 118-198 kg N ha-1x (basal + 3 split of nitrogen) x 67 hills m -2 treatment combination. Straw yield and harvest index increased with increasing nitrogen rate, its split and population density. Relationship between these three factors and yield of BRRI dhan29 revealed that 118-198 kg N ha -1 x (basal + 3 split of nitrogen) x 67 hills m -2 treatment combination performed the best in


The effect of introducing a cationic group to the substate on the crystallization process of electrostatic interactional silica colloidal crystals formed via heterogeneous nucleation was investigated by measuring the reflection spectrum and Kikuchi-Kossel diffraction patterns of the colloidal crystals on two types of substrate: one charged negatively by silanol groups and one with introduced amino groups. On the negatively charged substrate, the colloidal crystals formed a body centered cubic (bcc) structure and a face centered cubic (fcc) structure. On the other hand, on the substrate introduced amino groups, the colloidal crystals formed only bcc structure. The decrease in the close packing trend of the colloidal crystallin lattice was derived from the decrease in the particle mobility on the substrate with introduced cationic groups through the interaction between the negatively charged silica particles and the substrates, which resulted in the prevention of the crystalline lattice disproportionation.


How to effectively compress and represent the large-scale graphic data becomes the fundamental issue for analysis and processing. Graphic data compression technology is an effective solution to significantly reduce the storage space while supporting fast access in the compressed form. An in-depth analysis is provided on the current development of the technologies, including compression technology based on the traditional storage structure, Web graph compression technology, social network compression technology and compression technology for a particular query. A detailed analysis and performance comparison about the representative methods of each technology is presented. Finally, the summary and prospect are listed.


Environment is the aggregate of surrounding things. The surrounding things like air, water, minerals, organism etc.; includes social and cultural forces that shape a life of person or entire population. Good environment is essential for a balanced life. Lack of environmental protection due to different types of pollution threatens the life of the people. Environmental protection generally relates to the protection of physical surroundings i.e. forest, trees, plants, wetlands, animals etc. But overall environmental protection also needs to include the social, psychological and the moral values. Buddha a great teacher can be said as the pioneer in protection of the physical as well as mental environment. According to Buddha actual up grading the life of people is possible only by protecting physical and mental environment of the people. Buddha has given importance of proper environment to get success in physical as well as spiritual development. According to him the overall development of a people start from the environment he is living in. According to Buddha good environment include less polluted place, with protection of nature, having necessary opportunity of good education, medical cure, employment facilities and opportunity of spiritual practice. It is obvious that one can live and get success easily physically as well as spiritually, if he is an inhabitant of good environment. Generally accumulated kamma is the decisive force in shaping the life style of a person. But good environment also plays vital role in making good or bad life. This is the main motto of this paper, "The Green Buddhist view to solve the modern *. Ph.D., West Bengal, India. BUDDHIST APPROACH TO RESPONSIBLE CONSUMPTION AND SUSTAINABLE DEVELOPMENT 130 day's problem". Purpose of this paper is to show how Green Buddhist view in Pali & Sanskrit literature from the perspectives of green applied Buddhism may be viewed as the new horizon of knowledge which has unveiled recent unprecedented developments in bio – medical, scientific and technological researches. Findings of this paper are the peripheral atmosphere is gravely polluted because the interior atmosphere in the mind is seriously damaged. The bottomless gluttony has pushed mankind to satisfy too much and unnecessary demands, and take them into neverending competitions, leading to self-destruction and environmental damage. Contrasting to the distasteful and voracious mind is the spirit of simple living and contentment by those who practice the Buddha's teaching & the effects of the Green Buddhist teachings on the environment. In conclusion we can say that the environment has become a prominent issue times. Though environmental issues were not as major in Buddha's time as they have become today, Buddhism has an understandable ethic when it comes to the environment. Living in harmony with the environment is a key part of Buddhism. And how the green philosophical view is changing the people's mind from gluttony to the purified mind & we all know that mental health is the main key for good physical health. If people's mind will remain satisfied then definitely their families & society will live in peaceful atmosphere.


An enhancement of intercalation by ion implantation has been observed. It is shown that by seeding the graphite sample with 23Na ions through ion implantation, subsequent intercalation with sodium using conventional techniques reaches a higher sodium concentration than for an unimplanted sample. This enhancement has been also achieved by ion implantation of argon (40 Ar) which is a chemically inert gas, implying that this enhanced intercalation of sodium into graphite is due to implantation-induced structural disorder rather than a chemical effect associated with the implanted species.


106 Ss made judgments of numerosity after they were exposed to the judgments of male confederates. There was a curvilinear relationship between communication discrepancy and immediately measured opinion change. The prediction that with delayed measurement retention of the changed opinion would dissipate over time was not significantly supported. A significant linear trend interacted with the curvilinear trend in the immediate measurement condition. These results were interpreted as being consistent with the sleeper-effect phenomenon.


I entered graduate school in the fall of 1967 with very poor preparation. I had left the British army at the end of 1965 and came to America in January 1966. I had heard that American universities accepted credits for previous academic work and I wanted an undergraduate degree. In those days the British Military Academy (Sandhurst) covered academic subjects as well as military ones. I was actually taught military history by John Keegan. It was his first term at the institution having just "come down" from Oxford.2 I managed to collect almost a year and half of credits when I enrolled at Boston University (BU). Going to school full time, I graduated in eighteen months with a history degree. In the American survey course we read The Perils of Prosperity by William Leuchtenburg. At the beginning this book has a very evocative description of the small town and rural Midwest—that description stayed with me for some reason and made the prairie milieu seem


Although various previous studies have explored the relationship between agricultural service adoption and its economic impact, little is known about how it may affect environmental quality, especially chemical fertilizer application. Our study examines the effects of agricultural production services (APSs) on chemical fertilizer use, as well as the effects mediated by farm size, using a national representative survey data set comprising 1321 farm households from 132 villages in China. We show that farms adopting APSs tend to decrease the usage of chemical fertilizer and, thus, have less deviation from optimal chemical fertilizer application. Farms with large sizes are more likely to reduce the usage of chemical fertilizer. Moreover, farm size has a significant mediating effect on the relationship between APS adoption and chemical fertilizer use. In particular, farms adopting APSs are more likely to expand farm size, resulting in chemical fertilizer reduction. Our results suggest that APSs contribute to promoting the scale operation and environmental quality in agriculture.


Implanted biomedical sensor networks provide a major application of sensor networks in the near future. They collect desired biometric data and communicate the data wirelessly to a base-station through a multi-hop network. Their high temperature due to wireless communication and circuitry power consumption, for a prolonged period might damage the surrounding tissues. This paper presents an efficient thermal-aware routing protocol based on Shortest Hop Routing algorithm. Our proposed protocol states that when some nodes in the shortest path have a high temperature, the protocol ignores this path and routes packets through other paths whose nodes have lower temperatures. The simulation results prove the superiority of the proposed method compared to other thermal-aware routing protocols in terms of reducing temperature without a significant increase in packet delivery delay and power consumption of nodes.


ANDERSON, P. J. S. and VERSTER, ANNA, 1971. Studies o n Dictyocaulus filaria. I. Modificatio ns of laboratory procedures. Onderstepoort]. vet. Res. 38 (3), 181-184 (1971). Techniques used in a study of the life-cycle of Dictyocaulus filaria (Rudolphi, 1809) are described. First stage lar vae migrate from faecal pellets placed in water. Infect ive larvae are cultured in clean water at room temperature and aerated overnight for 7 days. Sheep are infested per os with infective larvae. A t various intervals after infestation they are killed and their organs are cut into small pieces, placed in a modified Baermann apparatus and the parasites allowed to migrate from the tissue into physiolog ical saline at 37°C for 6 to 8 hours. Larvae are collected from lymph drained from the thoracic duct with a catheter. Some of the recovered worms are killed with an iodine solution; others intended for morpholo gical studies are killed by heating to 60°C and preserved in a mixture containing triethanolamine.


This report is the final document related to the second year, second activity whose title is: "Preliminary results obtained by using the 2D numerical propagation model and sensitivity analysis with respect to the parameters".The purpose of the collaboration between LAMPIT (Department of Soil Defence, University of Calabria) and CMCC is to develop an hydrometeorological chain in order to obtain a reliable tool in the context of flood evolution prediction able to provide quantitative information of practical importance within the civil protection activities.The LAMPIT contribution to the project concerns the mathematical description of both the generation and propagation of flood events at basin scale. The work here presented, carried out in close cooperation with dr. Pasquale Schiano and CIRA researchers (dr. Paola Mercogliano and dr. Gabriella Ceci), has been organised as follows:- Analysis of the models proposed in the technical literature with particular reference to the kinematic and diffusive approximations.- Collection and description of numerical tests usually used in the scientific context for the validation of the numerical models.- Development and implementation of 2D models.- Validation of the models developed by LAMPIT through numerical tests.


Floor of a concrete bridge and a deformable stepping adapter engagement structure method and deformable, wherein the bridge is configured as a stepping layered structure, with a floor beam disposed embedded iron; stepping bridge a distance between a floor and leave the Deformation; long pass iron mounted on the end face of the concrete floor structure and tread; metal into the U-shaped structure in the deformation joint, U-iron extends in the movement joint; U-iron is filled with asphalt flax; asphalt Ma wire layered with asphalt excelsior board; pre between the plate and the floor; iron cement mortar laid on the cushion; steel plate covered in cement mortar bedding, floor near the end portion of the embedded iron plate fixed by welding leaving a transverse gap; the polyurethane sealing material sealing the gap after welding. The present invention can satisfy the needs of large-scale projects in the deformation joint, but played a settlement, shock, expansion of the role and improve water resistance.


Summary This paper mainly deals with the almost surely exponential stability and exponential p-th moment stability for a class of stochastic Cohen–Grossberg neural networks with distributed delays and reaction–diffusion term. By constructing suitable Lyapunov functional, employing the nonnegative semi-martingale convergence theorem and applying matrix theory and stochastic analysis technique, two delay-independent and easily verifiable sufficient conditions are obtained to ensure the existence, uniqueness, almost surely exponential stability and exponential p-th moment stability of the equilibrium point for the addressed stochastic Cohen-Grossberg neural network with distributed delays and reaction-diffusion terms.


AUTUMN 2006 the overlap between radical periodicals and the new middle-class journals of popular progress by analyzing their fictional treatments of the distressed needlewoman. The length and richness of this final section indicates that, though this study begins in the late eighteenth century, its perspective and key concerns are very much those of a Victorianist. More specifically, they are those of a Victorianist interested in rescuing Victorian popular fiction (especially Reynolds), not only from the Victorian "acts of oblivion" with which the book concludes, but also from those twentieth-century critics (particularly Louis James) who perpetuate, even as they reverse, Victorian logic by representing such fiction "as a diversion from [radical] politics" and thus "a political defeat" (4). If, as Haywood admits, he unapologetically constructs "a metanarrative," representing the campaigns for and against radical reform—and the literary tradition they spawned—as both "ongoing" and fairly continuous (4), it is also true that his narrative finds both its telos and its hero in Reynolds. Ultimately, however, such interests and investments may make this well-researched and wide-ranging history of popular literature all the more appealing and useful to readers of Victorian Studies. Kelly Mays University of Nevada Las Vegas


This Master Thesis is a collection of all research activities developed to analyze the temperature drift of MIRAS instrument and perform amplitude calibration during the operational SMOS mission. Moreover, some preliminary results from SuperMIRAS instrument have been obtained related to baseline instrument calibration definition and Error Budget.


CD19-directed chimeric antigen receptor-modified T cells (CAR T cells) achieve durable remissions in about 30-40% of relapsed/refractory large B-cell lymphomas. T cell exhaustion and/or an immunosuppressive tumor-microenvironment may contribute to CAR T-cell failure. Pembrolizumab, an anti-PD1 immune checkpoint inhibitor, may reverse T-cell exhaustion following CAR T-cell therapy. We treated 12 patients with B-cell lymphomas who were either refractory to (N=9) or relapsed after (N=3) CD19-directed CAR T cell (4-1BB-costimulated) therapy with pembrolizumab 200mg IV every 3 weeks. Median time from CAR T-cell infusion to first pembrolizumab dose was 3.3 months (range: 0.4-42.8 months). Pembrolizumab was well-tolerated and the only ≥ grade 3 adverse events related to pembrolizumab were neutropenia (N=3; 25%). Best overall response rate after pembrolizumab was 3/12 (25%) [1 complete response; 2 partial responses]. One (8%) patient had stable disease, thus, 4/12 (33%) patients had clinical benefit. After pembrolizumab, 4 patients with clinical benefit had increase in percentage of CAR T cells by mass cytometry (CyTOF); 3 of 4 of these patients also had increases in CAR19 transgene levels by qPCR. Deep immune profiling using mass cytometry revealed increased CAR T cell activation and proliferation and less T-cell exhaustion in clinical responders. Together, PD1 blockade with pembrolizumab after CD19-directed CAR T-cell therapy appears safe and may achieve clinical responses in some patients with B-cell lymphomas refractory to or relapsed after CAR T-cell therapy.


Dr. Gendreau Chakarov received her Ph.D. in Computer Science and Cognitive Science from the University of Colorado Boulder where she examined how to integrate computational thinking into middle school science curriculum using programmable sensor technologies as part of the SchoolWide Labs project. She continues this work on the SchoolWide Labs Project as a research associate where she serves as the computer science and computational thinking specialist. Dr. Quentin Biddy is a Research Associate in the Institute of Cognitive Science. He is currently working with the iHUB and Schoolwide Labs projects researching and developing open source resources to support high school and middle school science teachers transitioning to Phenomena-Driven, Three-Dimensional Learning and assessment aligned to the NGSS. Through his work with the Schoolwide labs project, he is focusing on supporting middle school science teachers intentionally integrating Computational Thinking Practices into students' learning experiences through co-designed CT integrated NGSS aligned storylines. His research/work experience and interests focus on effective science learning and teaching, Phenomena-Driven learning, NGSS aligned 3D Learning and formative assessment, CT integration, Pedagogical Con-tent Knowledge, teacher professional learning, and the Nature of Science and History of Science in science education. Dr. Jennifer Jacobs is an associate research professor at the Institute of Cognitive Science at CU-Boulder. Dr. Jacobs has served as the PI or Co-PI on a variety of funded studies spanning mathematics and science education, with a particular focus on the development of curricular and professional learning resources for teachers and their impact on classroom instruction and student learning. – improve teaching engagement. My research and teaching interests include personalized learning, learning analytics, cyberlearning environments, educational digital libraries, scholarly communications, human-centered computing, and interdisciplinary research methods for studying cognition. I have written 140 articles on these topics, including over 80 peer-reviewed scholarly publica-tions.


Abstract Firms often utilize and coordinate adjustment of price, price promotions such as price discount and supply certain free samples to meet customer demands and achieve maximal profit in diffusion process of new product. While a product being introduced to the market, the firm has to use some strategies to attract the consumers to learn and buy the product. Some firms may choose pricing strategies, i.e. the skimming strategy or the penetration strategy, to recover its sunk costs quickly before competition steps in and lowers the market price or to learn the potential market and increased units sold. Another way to introduce the new product is to give consumers discount of the product, i.e. price promotion widely used in firms. Due to increasingly market competition, promotion has become the biggest expense item in company's marketing expenditure and has been frequently used as the most effective weapon by a lot of companies to increase their sales in the short term. Free samples are also an effective means for introducing and promoting a new product. It used to demonstrate a product's superiority and to attract a potential customer to try the innovation product and it can accelerate the diffusion process of new products. But because product sampling is expensive, a company needs to determine the "right" amount of sampling. This paper provides an analytical model for obtaining optimal decision jointly on sampling and price promotion. Based on sensitivity analysis, it investigates the interactions between the problem parameters and sampling, price promotions. Numerical study is also provided to demonstrate the contribution of the models.


This article deals with activities of clinics at medical universities in modern economic environment. It is proposed to develop the legal foundation for functioning of such a type of public health service, to introduce the informational and analytical system of clinics management devised by the author.A computer programs for evaluating the quality and efficiency of medical services in clinics at medical universities, offered by the author, will help optimize the therapeutic and diagnostic process in hospitals and evaluate the activities of medical workers by their final results.


Nowadays people tend to use mobile devices such as smartphone to access information to get more information about everyday life, especially about health. Diabetes Risk Application implemented on Android Smartphone can provide such information. This application need to be tested, so users can use this application to know the level of diabetes risk itself. Testing conducted with the aim to show that this application based on Android has successfully developed. Testing performed include application testing, system testing, hardware testing, and user acceptance testing. The results of all testing run showed that this application has been successfully developed.


Abstract : The U.S. Army is acquiring a system that superimposes instrument symbology on night vision goggle (NVG) imagery. However, previous research indicates that the symbology may distract a pilot's attention from obstacle detection, recognition, and avoidance and may interfere with proper scanning patterns. To test the effects of combining imager and symbology, 36 helicopter pilots were presented night-flight scenarios simulating NVG imagery only, symbology only, and imagery plus symbology. The aviators were required to monitor and respond to predefined scene and symbology targets. They detected and responded rapidly to a high percentage of targets when viewing the scene-only and symbology-only scenarios. Their performance decreased significantly when the two types of information were presented together, but the decrease was small when compared to the increased amount of information available in the display. Aviator performance improved with practice and was related to experience and eye dominance. The aviators suggested several modifications for the symbology suite.


Introduction Dynamic causal modeling (DCM) is an important tool for analyzing functional integration between different regions of the brain (Friston et al., 2003). Apart from very few exceptions (e.g. Kasess et al., 2008) the overwhelming number of DCM studies used data with repetition times (TR) greater than 1 second. However, it seems clear that the use of shorter TRs shows a number of advantages. First, shorter TRs simply increase the number of data points resulting in improved model fitting. Higher sampling rates also allow for better coverage of the hemodynamic response, thereby enabling better coverage of possible transient effects, particularly in event-related designs. Another advantage of short TRs is that differences in slice timing become less problematic (Kiebel et al., 2007). Clearly, there are also problems using short TRs, most notably the decreased coverage of the brain leading to a possibly restricted set of regions that can be analyzed. In this work we have investigated the effects of different repetition times at varying noise levels on the model selection outcome using simulated data based on a hypothetical 3-region network (fig. 1).


Innovation is the main driving force of the enterprise's sustainable development, and the important way for extending the life cycle. Quality is the enterprise's eternal goal and the guarantee to gain a large share of the market with interests. As a new concept, innovation quality draws more attention. Based on the related literature at home and abroad, this article outlines the concept of quality and innovation and the influence factors, analyses and integrates the concept of quality and innovation as well as influence factors, and puts forward the integrated framework of innovation quality, laying the foundation for follow-up study and practice.


Skillful knowledge is a kind of "know-how" knowledge. The acquisition of skillful knowledge depends not only on knowers' understanding of explicit knowledge, but also on knowers' usage of tacit knowledge in certain practices. The growth of skillful knowledge is a dynamic process, which bears on the normative issues involved in explicit knowledge and tacit knowledge. The growth model of skillful knowledge shows that knowers, through skillful activities, establish the theoretical knowledge about the world on the one hand, and deepen their practical knowledge in actions on the other hand.Thus, from those points, knowers' plural cognitive styles and their effective knowledge of the relationships between knowers and situations will be philosophically discussed in this paper.


** ** compound of formula wherein A is C1-C4 alkyl optionally substituted with C1-C2 or mono or disubstituted with halogen an alkylene group; Z is a bond, O, S, C (O) NH or a C1-C3 alkyl optionally substituted with C1-C2; R1 is hydrogen, alkyl having 1 to 6 carbon atoms or phenyl; wherein the phenyl is optionally substituted with up to three groups selected from halogen, hydroxyl, C1-C6, C1-C6 alkyl, nitro, amino or mono or dialkyl (C1-C6) amino; R2, R3, R4 and R5 are each independently hydrogen, halogen, nitro or an alkyl group of 1 to 6 carbon atoms, the alkyl group optionally substituted with one or more halogens being; OR7, wherein each R7 is independently hydrogen, an alkyl group of 1 to 6 carbon atoms, the alkyl group optionally substituted with one or more halogens or benzyl phenyl, wherein the phenyl moiety is optionally substituted with up to three being groups independently selected dehalogeno, C1-C6 alkyl or C1-C6; phenoxy, wherein the phenyl moiety is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl or C1-C6.


Electrophysiological studies (EEG, evoked potentials, nerve conduction and EMG) in 13 patients with myoclonus epilepsy with ragged red fibres (MERRF) are presented. The most notable findings are the presence of atypical irregular generalized spike and wave discharges arising from an abnormal EEG background (9 patients), focal epileptiform abnormalities (6 patients) most commonly over the occipital regions and giant cortical SEPs (4 of 6 patients tested). Similar findings of disturbed EEG background activity, generalized spike and wave discharges and giant cortical SEPs appear to be shared by the group of diseases characterized by progressive myoclonus epilepsy.


Electrochromic molybdenum trioxide thin films were prepared by thermal oxidation in air of electrodeposited molybdenum trisulfide. MoO 3 prepared at temperatures ranging from 400 to 550°C were found to be polycrystalline. The best electrochromic properties (coloration efficiency and coloration time) evaluated in 1 M LiClO 4 /propylene carbonate were observed for films prepared by annealing at 425°C for 10 min. The coloration efficiency (35 cm 2 /C) for these optimum films compare well with those reported in the literature. The intensity of coloration of the film (absorbance at 634 nm) was found to scale linearly with film thickness. The electrochemical reduction of MoO 3 involves the transformation of Mo 6+ species to Mo 5+ , evidenced by x-ray photoelectron spectroscopy. The stability of molybdenum trioxide-coated tin oxide electrodes upon cycling and switching between oxidized and reduced states was investigated by cyclic voltammetry, potential-step experiments, and in situ spectroelectrochemistry. The results indicate that the stability of the molybdenum trioxide electrode is improved when it is used in a 0.1 M LiClO 4 , 14 mM HClO 4 , 2% H 2 O/PC solution rather than in a pure, nonaqueous electrolyte such as 0.1 M LiClO 4 /PC. The improved stability is related to the fact that the chemical disorder induced by cycling the MoO 3 electrode in the protic media is much less severe than in the aprotic media, primarily because while Li + are intercalated in the latter, only protons are intercalated in the aqueous/nonaqueous mixture


Objective To investigate the effects of hyperhomocysteinemia(HHcy) on myocardial endoplasmic reticulum stress( ERS) in Apo E- /-mice and its possible mechanism. Methods Thirty- six 5- week old Apo E- /-C57 BL /6J mice were randomly divided into three groups,including Apo E- /-control group,Apo E- /-HHcy group and the intervention group. Twelve 5- week old normal C57 BL /6J mice were served as normal group. After 20 weeks of feeding,the aortae were separated for HE stain and observation of aortic plaque. GRP78,CHOP and Caspase- 12 mRNA levels were determined by qRT- PCR. The methylation status of GRP78 and CHOP were studied using the nest touch down methylation specific polymerase chain reaction( nt MS- MSP). Results No significant aortic plaque was observed in either normal group or Apo E- /-control group. In the Apo E- /-HHcy group,the aortic plaque areas were greater,breaking into the aortic lumina,which were alleviated in the intervention group. The mRNA levels of GRP78,CHOP and Caspase- 12 in the Apo E- /-HHcy group were significantly higher than those in Apo E- /-control group( P 0. 05,P 0. 01),while they were significantly down- regulated in the intervention group( P 0. 05,P 0. 01). GRP78 and CHOP DNA methylation levels were significantly lowered in the Apo E- /-HHcy group( P 0. 01,P 0. 01),while significanty higher in the intervention group( P 0. 05,P 0. 05). Conclusion HHcy may affect Myocardial ERS via changing DNA methylation levels,then lead to apoptosis. Earlier folic acid and VB12 interference can effectively reduce the myocardial ERS and apoptosis.


In this work, we investigated the performance of single and double-glazed flat plate solar collector using a numerical approach. 1D and 3D models were developed by the thermal network model and the finite element model, respectively. We incorporated two different types of glasses with and without anti-reflection (AR) coating whose average transparency was measured to be 0.915 and 0.966 respectively. The loss coefficient of single and double glazed collectors were extracted to be ~3.234 and ~2.789, respectively, due to the decrease of convective loss for the double glazed design. With the AR coating, the single and double glazed collector showed ~88.8% and ~87.9% of the absorption capability, which makes the double-glazed design perform better than the single one. In addition, we investigated the spectral response of Cu-based nanostructured absorber plates and compared their performance with the conventional TiNOX absorber plates.


Coupled-bunch instabilities excited by RF cavity high order modes or resistive wall impedance can seriously limit the performance of third generation synchrotron light sources like ELETTRA. These instabilities can be cured by the use of active feedback systems. In the digital bunch-by-bunch approach adopted at ELETTRA, the position of the 432 bunches is sampled and corrected employing 500 Msample/s A/D and D/A converters. The correction values are computed by a multi-processor architecture made of state-of-the-art DSPs (Digital Signal Processors). A modular design allows to use commercialoff-the-shelf (COTS) components for the most critical parts of the system.


The circular economy (CE) is aimed at closing material loops by reducing and recovering resources in production and consumption processes. Many studies have discussed how CE helps companies create business opportunities while bringing environmental benefits. The business case for CE involves complicated issues such as industrial symbiosis, governmental interventions and the transformation of company culture. It is important to consider the whole context of CE when changing policies or business elements to optimise resource efficiency and avoid unsustainable consumption. By reviewing industry research reports and academic studies, this article summarises important circular business models and strategies and indicates current major barriers to CE. In addition, we explore multiple business cases and point out three important considerations that, if not used correctly, can lead to improper policies and environmental degradation when designing circular business models. These are (a) the use of biodegradable materials, (b) modular design for product life extension and (c) upcycling for new production processes. We then present a framework for companies to clarify vital considerations for resolving these issues based on systems thinking. The implications for business managers and policy makers are also discussed. This article serves to provide a better understanding of CE and explores how companies innovate in line with CE trends. Introduction


A soft-sphere discrete particle model was used to simulate mixing behavior of solid substrate particles in a slow rotating drum for solid-state fermentation. In this approach, forces acting on and subsequent motion of individual particles can be predicted. The (2D) simulations are qualitatively and quantitatively validated by mixing experiments using video and image analysis techniques. It was found that the simulations successfully predicted the mixing progress as a function of the degree of filling and size of the drum. It is shown that only relatively large straight baffles perpendicular to the drum wall (67% of the drum radius) increase the mixing performance of the rotating drum. Considering the different aspects of mixing dealt with in this work, it is concluded that the soft-sphere discrete particle model can serve as a valuable tool for investigating mixing of solid substrate particles. Finally, it is expected that this model may evolve into a potential tool for design and scale-up of mixed solid-state fermenters. MAI Schutyser, JT Padding, FJ Weber, WJ Briels, A Rinzema, RM Boom. Biotechnol Bioeng (2001) 75:666-675


This article traces the history of concerted black resistance to the film Gone with the Wind, whose popularity I argue was contingent on its expression of white nationalist pro-Confederate, pro-slaveholder Lost Cause mythology. By centering the voices of the resistance, this article offers a corrective to previous scholarship that fails to grasp the resistance's significance or frames it as merely provoked by the offensive nature of the film's racist imagery and language. Instead, at the heart of the protest was the danger that the film's mythology posed to black communities if it became entrenched in white national historical consciousness. Activists were correct about the film's ideological impact, and their protests wielded real influence, altering the film's final product to be less overtly racist. However, failing to stop Gone with the Wind, while muting its most racist components, contributed to the film's incredible popularity and its longevity.


We report a case, where a patient of chronic kidney disease developed hiccups and alteration of consciousness after consuming star fruit. Prompt recognition of his features lead to commencement of hemodialysis, and that saved his life. DOI: http://dx.doi.org/10.3329/bccj.v2i1.19968 Bangladesh Crit Care J March 2014; 2 (1): 40-41


MAY / JUNE 2018 Amid intensifying drought and wild temperature variations, farmers across the southern half of the Plains watched rangeland, pastures, and winter wheat turn brown or wither. In contrast, snow periodically blanketed the northern Plains and upper Midwest, although early-January cold blasts locally resulted in temperatures below –40°F. Meanwhile, Western precipitation was often confined to the northern tier of the region except during one notable storm, on January 8–9. During that renegade storm, heavy rain swept across Southern California and the southern Great Basin. At the height of the event, mudslides and debris flows devastated several Southern California communities, some of which had recently dealt with wildfires. Outside of the western United States, one of the month's most significant storms brought blizzard conditions to parts of the Plains and upper Midwest on January 21–22. Snowfall totals locally in excess of a foot were reported from Nebraska into the upper Great Lakes region. Elsewhere, periods of rain and wintry precipitation affected the South, East, and lower Midwest. Those regions also had to contend with earlyto midmonth cold waves, including some of the South's coldest weather in nearly 30 years. The Southern cold wave, which peaked on January 17–18, was preceded by multiple rounds of snow.


Abstract : Recent publications have drawn public attention to the growing evidence that a number of synthetic and naturally-occurring chemicals may disrupt normal function of endocrine systems. The scientific debate regarding endocrine disrupting chemicals (EDCs) centers around the insufficient data available to determine the ecological and human risks associated with environmental contaminants. This is partially due to the complex role of the endocrine system in regulating multiple physiological functions. Currently, the majority of EDC studies are focused on a few, well-known substances: DDT/DDE, dioxins and PCBs. Research fails to provide data on the majority of chemicals in use. The U.S. Air Force is placing emphasis on proactive reviews of its materials to preclude revelations which-may impact mission readiness. The project evaluated the health effects of chemicals commonly used by the Air Force for evidence of potential endocrine disruptor activity. The chemicals selected for review were compounds not previously evaluated for endocrine disrupting activity: organic solvents (trichloroethylene, trichloroethane, dichloroethane, methyl ethyl ketone, methyl isobutyl ketone and perchloroethylene), deicing and anti-icing agents (potassium acetate, sodium acetate, ethylene glycol,urea, propylene glycol, sodium formate and calcium magnesium acetate) and jet fuels and related hydrocarbons (toluene, ethylbenzene, xylene, jet fuel and diesel).


A new record centric diatom was found from Donghu Lake,Wuhan during the periphyton ecology investigation in 2004-2006,it shows close affinity to those of marine Eupodiscaceae species because of remarkable ocellus.As result,it is Pleurosira laevis(Ehrenberg)Compere.According to the study of Compere in 1982,we agreed that the name of Proteucylindrus taiwanensis Li et Chiang from Taiwan and Cerataulus laevis var. chinensis Grunow from Guangdong should be moved into this genus as P.socotrensis(Kitton)Compere.So,both species of Pleurosira were found from China.


High‐resolution clay mineral assemblage combined with Nd and Sr isotopic compositions of Core MD12‐3434 located in the northern South China Sea was investigated to reveal terrigenous sediment response to the East Asian monsoon evolution during the last glaciation. Clay mineralogical variations indicate clear millennial‐scale oscillations that are mainly due to rapid changes in the proportion of smectite to illite and chlorite. Smectite is derived predominantly from rapid chemical weathering of volcanic rocks in Luzon under strong summer monsoon, while illite and chlorite are mainly sourced from Taiwan through reinforced physical erosion. Thus, the smectite/(illite + chlorite) ratio is adopted to reconstruct the East Asian summer monsoon evolution during the last glaciation. Rapid increases in the smectite/(illite + chlorite) ratio imply strengthened summer monsoon occurred during Dansgaard‐Oeschger and Bølling‐Allerød interstadials. In contrast, rapid decreases in the ratio indicate relatively weakened summer monsoon happened during Heinrich and Younger Dryas stadials. These millennial‐scale climatic signals documented by clay mineralogical compositions of deep‐sea sediments in the South China Sea can be better preserved in calm deeper‐water sedimentary environments. Our study highlights the prompt responses of the East Asian monsoon system to millennial‐scale climatic changes occurred in high‐latitude Northern Hemisphere through contemporaneous chemical weathering of volcanic rocks and/or sediment supply variations under strong physical erosion in the low‐latitude South China Sea, implying an atmospheric teleconnection from the North Atlantic to the Asian monsoon region.


In text-to-speech (TTS) systems, an effective morphosyntactic classification is important to improve the prosody of synthesized speech as well as the pronunciation of words subject to vocalic alternation. This research work presents a methodology used for developing and assessing an ad hoc morphosyntactic parser to a TTS system for Brazilian Portuguese. The developed parser is composed of a dictionary and a set of rules structured in four levels. The methodology used for development consisted firstly in the creation of a large annotated dataset and an incremental development of rules for morphosyntactic classification. By using this approach, the achieved accuracy rate of the classification process is of 98.59% for words and 80.66% for sentences in a specific dataset.


Therapeutic proteins are fast-acting and potent medicines and have proved very successful in the treatment of a wide range of indications. With increasing knowledge of the molecular mechanisms of disease, there will continue to be opportunities to develop protein therapeutics. One estimate is that the global protein therapeutics market will be approximately $315 billion by 2025 [1]. Much of this growth can be attributed to the development of monoclonal antibody therapeutics as new targets are uncovered (e.g., checkpoint blockades). While there will likely be a rise in the development of bispecific antibodies and multifunctional antibody-based medicines (e.g., antibody drug conjugates (ADCs)), there are non-antibody-based proteins such as replacement and non-endogenous proteins still being developed. Strategies have been employed to increase the half-life and duration of action of these proteins to make them viable medicines. Endogenous (e.g., blood factors) and exogenous non-antibody proteins will continue to be developed. Therapeutic proteins are far from ideal molecules to be used as drugs. Development is often hampered by problems owing to limitations in (1) physiochemical instability (e.g., propensity to aggregate), (2) immunogenicity (e.g., ability to induce the formation of antidrug antibodies) and, (3) suboptimal circulation halflife and/or duration of action. Proteins that are rapidly cleared from the circulation must be dosed frequently, which can create toxicity and immunogenicity concerns. Poor pharmacokinetics (PK) properties are characterized by dose dumping, resulting in a subtherapeutic concentration between each repeat administration, which can have a significant impact on therapeutic efficacy. Optimizing protein PK cannot be considered a "bolt on" step in the preclinical development process. Establishing and optimizing PK properties from the outset should be integrated in the development of protein-based medicines. Optimal PK and duration of action must be designed for the best medical outcome possible. If too short, there are problems associated with too frequent administration. If too long, there could be potential problems with loss of protein stability, lack of ability to rescue a patient if needed, and possible toxicity issues. The expectation is that the continued development of half-life strategies will continue, hand-in-hand with the development of new innovative protein therapeutics.


When German soldiers and civil servants take hold of Poland in 1939, they see this country through the lens of ideas and stereotypes that are already old: the East is a backward, poor and dirty territory. From 1942 onwards, after the decision to kill all the Jews of Europe has been made, films and texts produced by the sanitary offices of the Wehrmacht and of the SS teach the German occupation forces how to "treat" the pathologies encountered in the East—above all typhus, which is meant to be genuinely Jewish. This biological conception of the "Jewish danger" presents the "final solution" as an unavoidable medical treatment, as a sanitary eradication.


We have reached a stalemate. Taken in its philosophical context, the manuscript reading —'perfectly', in the sense of completely and with a view to the best—is more natural than . But there are some excellent philological reasons for thinking that Stobaeus' reading is correct—especially the fact that appears nowhere (else) in any author. I would not go to the stake to defend either reading; but if I had to choose, I would (without much confidence) go with the manuscripts and : the gods 'manage the entire heavens perfectly'—that is, they neglect nothing, and see to what is best for everything as a whole.15


ABSTRACT Objective: Executive functions (EFs) have been assessed with performance-based measures and rating scales. Research has shown a lack of association between these two methods. One factor that might contribute to this difference is the structure provided on performance-based measures that is not provided on rating scales. This study examined the role of structure on self-directed task completion, an aspect of EF, using a novel unstructured performance-based task (UPT). Method: Children aged 8–12 years (38 attention-deficit/hyperactivity disorder, ADHD; 42 typically developing) and their caregivers participated. We compared performance on the UPT, performance-based measures of EF (Stroop test and Trail-Making Test), and a rating scale to assess EF (Barkley Deficits in Executive Functioning Scale–Children and Adolescents, BDEFS–CA). Results: Group differences were found across all measures. Significant associations emerged between the UPT and Stroop test, Trail-Making Test, and BDEFS–CA, but no significant associations were found between the Stroop test or Trail-Making Test and the BDEFS–CA. In regression analyses, performance-based tasks and the rating scale both uniquely predicted UPT performance. The UPT was a significant predictor of group status when entered with performance-based tasks, but the UPT did not enter as a significant predictor when entered with the rating scale. Conclusion: The UPT is a promising measure to assess self-directed task completion in children with ADHD.


High power laser beam welding represents a cost-effective alternative for fast joining of thick components. However, the reliability of the welded structures can be severely affected by solidification crack formation, caused by constructional restraints. Experimental investigations using 15 mm thick plates of the fine grained structural steel S690, welded with a 20 kW fiber laser under different restraint conditions revealed a relationship between hot cracking susceptibility and restraint intensity. Systematic laser welding experiments were conducted in the IRC (Instrumented Restraint Cracking)-test facility, under both free shrinkage as well as defined restraint intensities. In order to assess the stress-strain condition of the weld during solidification which is crucial in the hot crack formation process but also difficult, if not impossible to acquire experimentally, a two-dimensional thermo-mechanical finite element model of the IRC-Test was developed. The results constitute a good approach to explain and understand the detrimental effects of high restraints on hot cracking phenomena during laser beam welding.High power laser beam welding represents a cost-effective alternative for fast joining of thick components. However, the reliability of the welded structures can be severely affected by solidification crack formation, caused by constructional restraints. Experimental investigations using 15 mm thick plates of the fine grained structural steel S690, welded with a 20 kW fiber laser under different restraint conditions revealed a relationship between hot cracking susceptibility and restraint intensity. Systematic laser welding experiments were conducted in the IRC (Instrumented Restraint Cracking)-test facility, under both free shrinkage as well as defined restraint intensities. In order to assess the stress-strain condition of the weld during solidification which is crucial in the hot crack formation process but also difficult, if not impossible to acquire experimentally, a two-dimensional thermo-mechanical finite element model of the IRC-Test was developed. The results constitute a good approach to explain...


In Romania, approximately 9.1 millions of inhabitants live in the rural environment. Attention over the rural environment is first of all drawn because of the lower life standard compared to the urban environment, of the lower income that is obtained therein, of the smaller profits of the economic activities from this environment. Poverty in the rural areas is due mainly to low agricultural productivity and low opportunities of employment in other spheres besides the agricultural sector. The development of the rural areas and reduction of the high level of poverty from these areas can be achieved through rural social economy development support and incentive programmes, development of the human capital and increase of the social protection level in the rural environment. Encouraging of the development of rural entrepreneurship may contribute to the increase of productivity in the rural areas, and based on it, to the increase of the life standards of the inhabitants from the rural areas.


The friction factor data from transitional rough test pipes, from the measurements of Sletfjerding and Gudmundsson (2003, "Friction Factor Directly From Roughness Measurements, " J. Energy Resour. Technol. 125, pp. 126-130), have been analyzed in terms of directly measurable roughness parameters, R a the arithmetic mean roughness, R z the mean peak to valley heights roughness, R q the root mean square (rms) roughness, and R q /H rms textured roughness (H, the Hurst exponent is a texture parameter), in addition to h the equivalent sand grain roughness. The proposed friction factor λ, in terms of new scaling parameter, viz., the roughness Reynolds number Re Φ =Re/Φ (where Φ is a non-dimensional roughness scale), is a universal relation for all kinds of surface roughness. This means that Prandtl's smooth pipe friction factor relation would suffice provided that the traditional Reynolds number Re is replaced by the roughness Reynolds number Re Φ This universality is very well supported by the extensive rough pipe data of Sletfjerding and Gudmundsson, Shockling's (2005, "Turbulence Flow in Rough Pipe," MS thesis, Princeton University) machined honed pipe surface roughness data, and Nikuradse's (1933, Laws of Flow in Rough Pipe, VDI, Forchungsheft No. 361) sand grain roughness data. The predictions for the roughness function ΔU + , and the roughness scale Φ for inflectional roughness compare very well with the data of the above mentioned researchers. When surface roughness is present, there is no universality of scaling of the friction factor λ with respect to the traditional Reynolds number Re, and different expressions are needed for various types of roughnesses, as suggested, for example, with inflectional roughness, monotonic roughness, etc. In traditional variables, the proposed friction factor prediction for inflectional roughness in the pipes, is supported very well by the experimental data of Sletfjerding and Gudmundsson, Shockling, and Nikuradse. In the present work, the predictions of friction factor as implicit relations, as well as approximate explicit relations, have also been proposed for various roughness scales.


We have investigated the relationship between surface roughness and morphology and the formation of self-assembled monolayers (SAM). Rough surfaces were prepared by abrading polished Si[100] wafers with SiC paper. Dodecan (-C/sub 12/H/sub 25/) SAM were prepared by refluxing the samples in a 30% dodecene solution in mesithylene. The FTIR spectra of these samples were analyzed with respect to the CH/sub 2/- and CH/sub 3/- peak positions, peak intensities and peak widths.


The question of how to fund long-term care of older and disabled people has long confounded politicians across the developed world. While health care in England has been 'free at the point of delivery' since 1948, social care has been subject to means-tested charges. Last autumn the coalition government asked Andrew Dilnot, an Oxford economist, to come up with new proposals. Dilnot's commission has recently reported.1 Has he anything new to propose and why does this matter to general practice?

Long-time observers of social policy will be familiar with previous reviews,2–4 notably the Royal Commission on Long Term Care which reported in 1999.2 The failure to make progress is easily explained. Calls for free personal care, whatever the situation north of the border, were never likely to garner support from the English exchequer. (Following the introduction of free personal care in Scotland in 2002, there has been a substantial increase in demand for care which cannot be explained by demographic trends, higher rates of disability, or reductions in informal care.5) Dilnot thinks that the state should pay more for social care; but so must we. In specifying how — and with a degree of realism — his report represents an advance.

Reading earlier reports, one is struck by the commonality of concerns and phraseology. All parties agree that the current system is 'confusing, unfair and unsustainable.'1 Many people's last years are blighted by fear of penury. They are unable to plan ahead to meet their future care needs. This is the only area where people cannot pool their risks and protect themselves against …


The prediction of behaviours in dynamic and subjective environments is an interesting issue in the way to obtain a complete delegation of human-like decisions in autonomous agents. Complex mathematical algorithms have been proposed by academic researchers to be applied in agent-based recommendation systems. In this paper we propose to use a classic estimation method known as alpha-beta filtering. This innovative approach is compared with a previous proposal (called AFRAS) from the authors that it is based on fuzzy sets and that has been successfully compared with some of the most representative reputation models and with another classic estimation method (Kalman). This paper evaluates how consumer agents applying both methods predict the behaviour of provider agents focusing on the velocity of convergence of the predictions to the real behaviour where such behaviour adopts a prefixed variability


INTERPRI':TATIONS O1-" NIE'rZSC:IIE have been improving dramatically in the last decade, both in sophistication and in appreciation of his texts ancl issues. Nevertheless, there remains something disappointing about the tield of Nietzsche interpretation. As Bernd Magnus has noted, the main contributions to the fielcl come from three broad and roughly distinguishable groups: "analytical" interpreters who regard as their task the determination of Nietzscbe's views on distinct tractitional conceptual issues in philosophy, "deconstructionist" interpreters who regard philosophical issues as socially and historically conditioned and interpret Nietzsche accordingly, and "reconstructionist" or more purely scholarly interpreters who simply seek to make the most exhaustive and coherent account of Nietzsche's corpus. Magnus notes that these groups tend to talk past one another, indicates that their clifferences stem principally from divergent nmtaphilosophical commitments--divergent commitments about what "philosophy" as a discipline and activily is--and suggests that the controversy between these groups "can and ought to be surmounted." ' Because divergent metaphilosophical positions disagree about what constitutes a serious problem or a plausible view, a major ditticulty faced in overcoming such controversy is finding determinate issues and texts which can support proctuctive disagreement. This problem is especially acute wivh Nietzsche because clocumenting an interpretation of his views is so difticult that it scarcely allows for considering one's own interpretive principles, the reasons one fincts particular issues and passages compelling, or alternative readings of the texts. Thus both the principles about which these groups disagree as well as the textual issues on which they disagree remain in the background, making it diflicult to bring divergent interpretations into mutual focus. Nietzsche's own unprecedented emphasis on the importance of


For over two decades, the OpenGL API provided users with the means for implementing versatile, feature-rich, and portable real-time graphics applications. Consequently, it has been widely adopted by practitioners and educators alike and is deeply ingrained in many curricula that teach realtime graphics for higher education. Over the years, the architecture of graphics processing units (GPUs) incrementally diverged from OpenGL's conceptual design. The more recently introduced Vulkan API provides a more modern, fine-grained approach for interfacing with the GPU, which allows a high level of controllability and, thereby, deep insights into the inner workings of modern GPUs. This property makes the Vulkan API especially well suitable for teaching graphics programming in university education, where fundamental knowledge shall be conveyed. Hence, it stands to reason that educators who have their students' best interests at heart should provide them with corresponding lecture material. However, Vulkan is notoriously verbose and rather challenging for first-time users, thus transitioning to this new API bears a considerable risk of failing to achieve expected teaching goals. In this paper, we document our experiences after teaching Vulkan in both introductory and advanced graphics courses side-by-side with conventional OpenGL. A collection of surveys enables us to draw conclusions about perceived workload, difficulty, and students' acceptance of either approach. In doing so, we identify suitable conditions and recommendations for teaching Vulkan to both undergraduate and graduate students. © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).


In the last decade, we have witnessed a number of cases where a small deviation from crystallographic or average structure strongly modifies electron states, physical and chemical properties and functions. The crucial role of breaking local symmetry, stabilizing a certain electronic (spin-state) configuration, has been recognized recently, by x-ray absorption spectroscopy (XAS). In biological systems such as haeme proteins, having 3d transition metal ions at active sites in a large molecule, XAS studies clarified the intimate relation between the local structure and the spin state. A number of high Tc superconducting oxides have been investigated and a generic behavior of local lattice as an intrinsic tendency of highly correlated electrons is revealed. We find anomalous local lattice distortions in YBa2Cu3Oy emerge at characteristic temperatures T* and T0 associated with changes of electron states, indicating a strong electron-lattice coupling. We demonstrate that in situ XAS can probe the local lattice ...


The rheumatic manifestations of endocrine diseases are well-known. The endocrine system has a complex effect on the structure and function of musculoskeletal tissues. The symptoms of locomotor apparatus injuries often come to the forefront in the clinical picture of an endocrine disease. It is therefore important to put endocrine diseases, including hypothyroidism, arthropathy, myopathy, etc., in a range of differential diagnoses of musculoskeletal system lesions. It should be remembered that changes in the locomotor system are able to partially or completely regress when endocrine disorders are adequately and long compensated for. The paper describes a clinical case in which, despite an obvious diversity of the typical clinical presentations of hypothyroidism, the main complaint was pain in the joints and muscles. In this connection, the female patient was initially misdiagnosed. This could be avoided if there was alertness to endocrine arthropathies and myopathies.