We thank Boyapati et al. for their interesting comments regarding our recent article. 2 Dealing with a loss of response to infliximab is often awkward, in terms or deciding whether to intensify infliximab therapy or to switch to an alternative. While infliximab dose intensification restores clinical response in 60–90% of patients in the short term, only 35–47% of the responders will remained in remission at 12 months. In that setting, the economic burden of dose intensification could be useless since patients will have to switch to another treatment sooner or later. On the other hand, a significant proportion of patients who respond to dose intensification will be able to go back to a standard dose of 5 mg/kg (59% of the patients in our study).Furthermore, the efficacy of a second anti-TNF after secondary failure of infliximab has been shown to be poor in Crohn's disease. We agree with Boyapati et al. that loss of response was not defined adequately. In our study, it was defined according to physician global assessment. However, the vast majority of patients presented with high partial Mayo score [median partial score of 7 (95% confidence interval 6–8)] and all of them had active disease according to this previous score assessment. 7 We fully agree that therapeutic drug monitoring is a cornerstone in the management of patients who lose response to infliximab and is currently lacking in our study. Indeed, it has been shown that infliximab could be consumed by the inflammatory burden, immunogenicity of the drug, and faecal loss. However, time is not on our side when loss of response occurs, and it is often difficult to wait for the results of therapeutic drug monitoring to decide whether infliximab therapy should be intensified. New assays that provide a real-time assessment of the anti-TNF trough levels and the presence of anti-drug antibodies are needed for a personalised drug optimisation strategy.


Presents the chain of tools developed at BULL for the verification of circuit designs. For several years, BULL has been a leading site in the field of formal verification of hardware. Until now, the main concern of BULL was in the validation of the VLSI circuits of its mainframe CPUs. The effort is currently extended to board components such as PLDs and ASICs.<<ETX>>


This paper proposes a pulse-width-modulation (PWM) and pulse-frequency-modulation (PFM) hybrid modulation scheme to minimize the light load switching loss of a dual-input LLC resonant converter for photovoltaic (PV) applications. The converter voltage gain is controlled by adjusting the duty cycle at light load and varying the operating frequency at heavy load. Zero-voltage-switching (ZVS) is realized in all primary switches and zero-current-switching (ZCS) is achieved in secondary diodes over the entire range of source voltages and load conditions. In addition, voltage stress across switches does not exceed the input PV voltage. The dual-input LLC converter with proposed control scheme was established in L Tspice+PSIM softwares to analyze the performance. A 500-W dual-input LLC prototype was built to experimentally demonstrate the performance of the proposed hybrid modulation scheme. The input voltage range was selected to be 25 V to 50 V with an output voltage regulated at 200 V DC. Experimental results are closely matching the simulation results. With the proposed modulation scheme, the converter light load efficiency can be improved by maximum 6% while maintaining the conversion efficiency above 90% for the entire power range.


A new similarity discretization method in FEM is presented while researching of quasistatic performance of micromachined microwave components by COMS technology. With the use of a recurrence relation, the new method not only uses much less computer memory than the conventional FEM but also simplifies the post-process.


The welfare, production performance and some qualitative characteristics of eggs obtained under three different rearing systems (conventional, organic and organic-plus) were compared. Three homogeneous groups, each of 120 White Leghorn hens, fed the same diets, were assigned to different rearing systems and data were recorded for 1 year. The welfare indicators were the following: first impact, behavioural patterns, tonic immobility and plumage status. Productive performance was recorded (% deposition; egg weight) and some qualitative traits (Haugh index, yolk colour, yolk, albumen and egg shell weight) were evaluated. Well-being was greatly affected by rearing system. The best welfare status was observed in hens of the organic-plus group, whereas the worst was in the conventional group (caged hens). Caged hens showed little interest or fear of observers, at times they had high tonic immobility and some aggressive pecking; the status of their plumage was very poor. On the contrary, caged hens produced more eggs, even if their qualitative traits (Haugh index and yolk colour) were worse than the organicplus eggs. The intense motor activity of organic hens and the concurrent intake of grass reduced their productive level; further egg deposition seemed more affected by seasonal variation.


Natural plasmids are present in fermented foods ranging from yogurts to sourdoughs, sausages, kimchi or pickling crabs. In this study, we describe the natural plasmids present in a product obtained by fermentation of bovine milk and colostrum. We used a microarray consisting in a chip covered in short DNA sequences that are specific to target microorganisms for a total of approximately 12,000 species. As far as plasmids are concerned, the array yielded 48 iterations, each one corresponding to a unique plasmid target. We discuss the putative role of some of these plasmids in contributing to the known properties of probiotics in supporting health and longevity.


Purpose
The purpose of this study is to investigate the effects of emerging market professional service small and medium-sized enterprises' (PSF SME) internal competencies and capabilities on their ability to establish relationship value among clients and achieve superior financial performance. This study addresses the paucity of research on emerging market PSF SMEs and their ability to build value for their clients.

Design/methodology/approach
Data were collected from 251 senior managers or owners of PSF SMEs who were from an emerging market economy but had operations in various foreign markets. The two-step structural equation modeling procedure was used to analyze the data and investigate the hypothesized relationships.

Findings
The results show the positive impacts of the PSF SME's human capital on innovativeness, service capabilities and relationship value. Human capital also had indirect positive impacts on relationship value and financial performance. Service capabilities were found to have a positive impact on relationship value and financial performance. In addition, innovativeness was found to have a positive impact on financial performance.

Practical implications
Emerging market PSF SMEs can gain competitive advantages and build solid long-term relationships with clients in the global marketplace when they focus on strengthening their human capital resources and successfully leveraging their innovativeness and service capabilities.

Originality/value
The study fills a gap in international business and management literature by offering guidance on how emerging market PSF SMEs can effectively use their internal resources and capabilities to build solid relationships with clients, deliver superior services and achieve global marketplace success.


Two simultaneous revolutionary changes are occurring in networking: the advent of mmWave networks and the advent of applications that require end-to-end delays of the order of a few milliseconds. mmWave is the first physical layer technology that promises huge wireless bandwidth, but with very poor reliability as a result of its vulnerability to blockage (optical fiber offers high reliability and high bandwidth; sub-6Ghz microwave networks offer lower bandwidth but graceful bandwidth degradation that can be mitigated). The emergence of the need for ultra-low delays for haptic communications and control loops in self-driving cars and other sensor-based applications, has radically changed the requirements for layers above the physical layer. These two changes transform standard networking problems and will lead to a new wave of research. Examples will be used to illustrate this paradigm shift.


In this study, a solver coupling the level-set and volume-of-fluid methods is developed for interface computation of incompressible two-phase flows on the OpenFOAM platform. It corrects the surface tension, density, and viscosity of the fluids with the level-set function synchronously. To examine the effect of density and viscosity corrections, an intermediate solver that only corrects the surface tension force is also developed. Two test cases, that is, a bubble rising freely in stagnant water and a drop impacting on a liquid surface, are performed to validate and compare the capabilities of the new solvers. It is found that the coupling solver which corrects all the fluids' properties mentioned above has the best prediction accuracy, especially for Rayleigh jet issues. With the application of this solver, the mechanism for the bubble entrainment in drop impact on a liquid pool is explained.


Working with faith communities in health promotion is widely acclaimed and yet not readily practiced. This article describes a study conducted among four faith communities to determine the process required for sustainable faith-based programs. Face-to-face interviews were conducted among 12 community volunteers who participated to identify their perceptions of the project. Two staff members were also interviewed to identify the process from their perspectives. Project-related documents were also analyzed to provide details and triangulate the data from the interviews. The study followed the project for 2 ½ years. Several factors were identified as significant influences on participation and project sustainability. These included value, active pastoral support, program success, and volunteer commitment. The results of this study indicate that pastoral support and faith community ownership are critical components that should be included in faith-based community building efforts.


The Soil Moisture and Ocean Salinity (SMOS) satellite mission of the European Space Agency (ESA), scheduled for launch in summer 2009, responds to the growing need for an accurate estimate of the root-zone soil water content. SMOS will operate at L-band frequencies, where the microwave signal is more sensitive to the soil water content. The European Centre for Medium-Range Weather Forecasts (ECMWF) is preparing to integrate this new data in its data assimilation chain ([1]). In this context, ECMWF has developed the Comunity Microwave Emission Model (CMEM) forward operator ([2]) to simulate the top of the atmosphere brightness temperatures (TB) in frequencies ranging from 1 GHz to 20 GHz as a function of the land surface conditions and vegetation. CMEM has a modular design and permits the combination of different parameterizations for each component of the soil microwave emission. [2] and [3] found that the Kirdyashev parameterization for the vegetation optical thickness was the best for the TB simulation. But little investigation was undertaken in the choice of the soil roughness model. A study over the SMOSREX field site [4] demonstrates that the calibration of this component is likely to be the most important in the microwave simulation. This paper investigates which soil roughness parameterization available in CMEM reproduces more accurately the observed TB. This study concentrates in the year 2004 using the operational configuration. Some results are showed in this paper.


ABSTRACT Systems which are built up from functionally identical elements having two inputs and two internal states are subjected to random initial positions and random structural connections such that a random determination of cycle length is achieved. This artifice enables tractable examination of the systems over varying system size. In particular we present a model for the distribution of the cycle length variable and also consider the effect of system size on cycle length.


Samples are taken from a periodic resonance signal by means of a gating circuit. The samples are smoothed by means of an RC filter and drive the Y axis of an X-Y recorder. The X signal of the recorder is driven by a voltage that is proportional to the value of the modulation field at the moment the sample is taken. Absorption curves and not their derivatives are directly obtained in this way.


ABSTRACT This paper proposes a data transformation to deal with the presence of constant under/over-dispersion relative to the Poisson or binomial assumptions. The proposed methodology is very simple as it does not require to replace the Poisson or binomial by more complex regression models based on more flexible distributions. The new approach consist of a transformation of the response variable, followed by the analysis of its relation with the covariates by applying to the transformed variable the usual Poisson or binomial regression models. The transformation depends on a tuning parameter, which can be easily chosen using a straightforward criterion. The efectiveness of the proposed approach is illustrated by simulation experiments and by analyzing six real data sets.


Lake Suigetsu, Fukui prefecture, central Japan, is one of 5 tectonic lakes located in the San'en triangle (e.g. Okada et al., 2010) partitioned by the Mikata and Hiruga Faults of the Mikata Fault Zone in a north-south direction and the Kumagawa Fault in a west-east direction (Nakata and Imaizumi, 2002; Okada, 2012). Lake Suigetsu preserves annually laminated sediments over the last ca.70 kyr (Nakagawa et al., 2012) with a significant number of event layers (Schlolaut et al., 2014). The sediment is one of the best-dated annually laminated materials in the world (e.g. Staff et al., 2011; Bronk Ramsey et al., 2012). Theoretically, the sediments have the potential to provide one of the most precise and highly resolved records of tectonic events in the world. In this study, we reconstructed a very detailed history of fault movements from changes of sedimentation rate in off-fault records using the new core drilled in 2014 (SG14) and the previously obtained and well-dated core (SG06). The SG14 core was obtained from a point ~320 m to the east of the SG06 coring site funded by the Fukui Prefecture. The SG14 core is composed of overlapping segments recovered from four nearby boreholes to ensure continuity of the whole archive. We also took high-resolution photographs of the sediment section on the coring site before any oxidation could take place. On the basis of these high-resolution photographs, we recognised more than 300 event layers in the SG14 core and precisely correlated them to their counterparts in the SG06 core. This enabled us to transfer the high-quality SG06 chronology to the SG14 core and compare sedimentation rate changes of both cores in an exceptionally high resolution and precision for the last ca. 50 ka. The result showed semi-cyclic step changes in the difference of the sedimentation rate at least three times over 50,000 years. That is, the relative sedimentation rate drastically increased at the eastern side of the lake, closest to the fault (SG14), after gradually increasing at the western side near the depositional centre of Lake Suigetsu (SG06). These cyclic step shifts were not synchronous with thick and very characteristic event layers such as turbidites. These findings suggest that: (i) the cyclic step changes in differential sedimentation rate demonstrate direct records of the deformation events due to slips of the Hiruga Fault, and (ii) much thicker turbidites that are seen in the lake's sediment (at least not all of them) were not always induced by the near fault's movement. We propose that the following sequence best explains the mechanism responsible for these subtle changes in sedimentation rates: 1. the eastern side of the lake was lifted relatively, due to a reverse-fault slip of the Hiruga Fault; 2. the sedimentation rate increased relatively at the eastern site of SG14 because of sediment focusing nearer the fault; 3. subsequently, the sediment focusing occurred further from the fault; 4. the sedimentation rate gradually increased at the western SG06 coring site located near the lake's depocentre; 5. the eastern site (SG14) was relatively lifted by the fault again, and the same sequence repeated for a number of times. These results are consistent with the subsidence events related to the activity of the Mikata Fault Zone estimated in the nearby Lake Mikata, located to the south of Lake Suigetsu (Ishimura et al., 2010). In summary, we have reconstructed a precise and highly resolved record of fault movements. The detailed ages as well as the typical recurrence period will be reported at this conference. SSS12-20 JpGU-AGU Joint Meeting 2017


The time‐varying gas temperature of afterglow plasmas is determined from the frequencies of standing acoustic waves which are produced during the breakdown of low‐pressure gases (0.1–20 Torr). The sound field is probed with free‐space microwave (9 and 70 Gc/sec) interferometers in transmission and reflection. Capacitor discharges are found to heat the gas significantly. The temperature does not decay to room temperature within the observed afterglow periods.


This longitudinal study examined whether parenting quality, parental behaviours and children's temperament at 6 months of age predicted children's creations of imaginary companions (ICs) at 44 months of age. At six months, parenting quality and parental behaviours were measured using the Parent-Child Early Relational Assessment, and the frequency of mental-state references made during mother–infant interactions was recorded. Temperament was assessed using the Revised Infant Temperament Questionnaire. Parents then completed questionnaires assessing whether their children had ICs at 44 months of age. The results revealed that only the approach characteristic of temperament marginally predicted children's IC status. Results of the parental measures showed that parents of children with ICs were more likely to attribute mental states to their child and to refrain from intruding in their child's behaviours than parents of children without ICs. The results indicated that parental behaviours are important for children's creation of ICs.


To develop a method for detecting trace element chromium,manganese,arsenic,cadmium and lead in blood by inductively coupled plasma mass spectrometry(ICP-MS),blood samples were pretreated with closed vessel digestion and then detected by ICP-MS.The results showed that the linear correlation coefficient(r)of each linear regression equation for the corresponding element was over 0.999,and each relative standard deviation(n=6)was under 5.0%.The recoveries by the method were in the range of 88.4%~107.6%.The detection limit of ICP-MS was in the range of 0.048~1.4μg·L-1.The study indicates that this method is accurate and convenient,and is applicable for detection of trace elements in blood.


Democratic Progressive Party established in 1986 is the largest opposition party in Taiwan, from establishing to coming into power total 14 years in growth and transition; held the reins of government in 2000 and lost power by the party alternation in 2008. Under the effect of democratic politics, the party alternation in Taiwan shall be evolved into normality. DDP, as a young political party, has gone through various policy processes and party leaders' policy decisions, even the party members who served in DDP or public office are elected by a democratic manner that makes DDP become the first political party to carry out the inner-Party democracy, much more the system of the primary election to nominate candidates through party members' vote and opinion polls. The young, innovative, and local root is DDP's characteristic; from local to central organization structure have all middle and lower ranks obtain an equal chance to join the political affairs. DDP defeated the many-year ruling Nationalist Party (or Kuomintang; hereinafter referred to as KMT) during the presidential election held in 2000. It is believed, DDP is a party can change the future of Taiwan, and create a brand-new cross-Straits relations under an equal and reciprocal circumstance. This local party in its early stage was striving for human and suffrage rights, then, from the secondary stage to the third, for social justice, rightfulness, welfare, and equality of educational resources. As to the cross-Straits issue, of course, there is a different from KMT in cognition. This essay is to explore the evolvement in respect of the policy toward Mainland China occurred in a period from Lee Deng-Hui succeeded to presidential office in 1988 to emergence of the politically new star--- Tsai Ying-Wen. In an era of military confrontation, both sides cut down the communication and had nearly no reciprocation each other, hence, Taiwan did not have the necessity to enact any China policy. Nevertheless, as China continuously tried to conduct the united-front strategy, Taiwan was passively obliged to enact the "China Policy" such as "The Three Principles Reunite China" and "Three Noes Policy" (no contact; no negotiation; no compromise), but it was no more than a slogan. In 1987, Taiwan lifted the ban and allowed residents to visit relatives in China. For cross-Straits unfolded an enthusiastically interflow, Taiwan's "China Policy" started changing from passive to active. Not but that cross-Straits had a 180-degree transition, both sides' relationship still lay in the phenomena of "Official Passion & Civil Indifference" because of the influence of ruler's subjective or objective factor. In particular, the controversial disputes in respect of the "Special state-to-state relations" advocated by Lee Deng-Hue in his late reign period forced China to unilaterally suspend the cross-Straits negotiation. On the one hand, China's doubt about the "Taiwan Independence" commended by Chen Shui-bian and DDP caused the official contacting channel being cut during Chen's reigning period, but not the civil interflow, which on the contrary, became more intense and frequent. The civil force urged the ruler to enact the guideline of "China Policy" that became even more important. During Chen's reigning period, Taiwan in the international was constrained by the US and China, and pinned down by the opposition party; how could the "China Policy" be produced? It is also worthy to make a further exploration if the "Domestic factor" is the key point to affect the said Policy. DDP was turned into the opposition party through the party alternation in 2008; it could become the ruling party again. Regardless of which parties in power, "China Policy" is an important issue to be actively faced by each party, either ruling party or opposition party. The formation of any argument or policy will be affected by contemporary time, space, environment, and context in a mass, in particular, the "China Policy" that could directly influence the cross-Straits relations. China has always doubt about DDP's China Policy, but has no choice but to face the possibilities that DDP might regain the power. After all, Taiwan is a democratic country, and the party alternation by democratic election is the normality of an advanced democratic state. Tsai Ying-wen transformed from a scholar to DDY's chairwoman in the duration of 2008~2012, proposing the "Decade of political program" and "China Policy", the formation and tendency of which has directly and indirectly affect our national development. Therefore, how to deeply understand the China Policy enacted by DDY after a party alternation, we expect that DDY will be helpful for both sides' relationship while we seek and explore how to develop a peaceful and stable cross-Straits relations.


The logarithmic transformation can be utilized to equilibrate variances of traits of different size when these variances scale proportionally to the square of the trait means. Oth- erwise variances will not be equilibrated by log transformation. A simple model of ontogenetic growth is utilized to show that trait variances increase with the square of the mean during ontogeny when individual growth increments are perfectly correlated. Alternatively, if these individual growth increments are uncorrelated, trait variance accumulates only in direct pro- portion to the mean itself. For most actual ontogenies, the incremental growths would not be perfectly correlated, so log-transformed variances would be expected to decrease during ontog- eny. The model was extended to address the comparison of variances between two traits differ- ing in size. When two traits are highly correlated, the ratio of variances of the traits will be proportional to the square of the mean ratio. When two traits are uncorrelated, the ratio of variances scales directly to the ratio of means. Biological traits are usually characterized by varying degrees of intercorrelation (i.e., they exhibit multivariate structure). Since the appro- priate transformation to accommodate scale depends upon the intercorrelation among a set of traits, it is unlikely that a single transformation would equilibrate variances (and covariances) among all traits. A similar caution applies to genetic variances and covariances in quantitative genetics. However, narrow-sense heritabilities and additive genetic correlations are both ap- proximately invariant under a change of scale and can be compared across traits and/or popu- lations with less concern about scale effect. (Logarithms; morphometrics; ontogeny; quantitative genetics.)


Objective Combined with myocardial tissues pathological changes after crush injury in rabbits,to evaluate the changes in left ventricular function by multi-functional complex cardiac ultrasound.Methods Forty-two New Zealand rabbits were divided into control group(6 rabbits) and crush injury group(36 rabbits),and crush injury group was further divided into immediately,6 h,12 h,24 h,48 h and 72 h after pressure relief groups in each group including 6 rabbits.The cardiac function was measured by multi-functional complex cardiac ultrasound,and the myocardial cells changes were observed by electron microscopy.Results All the rabbits were extracted 6 h after crush,the cardiac systolic and diastolic function indexes in immediately after crush group were decreased than those in control group,there was significant difference(P0.05).The left ventricular systolic function in 6 h and 12 h after crush group were decreased than those in control group(P0.01),while the left ventricular diastolic function was most obviously decreased in 24 h after crush group(P0.01).Mitochondrial swelling of myocardial cells could be observed by the electron microscopy.Conclusion In the early stage of crush injury,cardiomyocyte injury is induced,the damages are increased gradually,reach the peak after 12~24 h and sustain to 72 h after crush injury.Multi-functional complex cardiac ultrasound can assess the damage of heart after crush injury accurately,objectively and rapidly.


One of the modern directions in construction is the development of multistorey buildings, in which the main part of the structural elements is made of timber, and spatial stability is provided by reinforced concrete diaphragms or a stiffening core. A possible problem when using different materials in load-bearing structures is a significant difference in deformation characteristics and the effect of creep.


Due to its relatively low environmental pollution, plasma based surface hardening (e.g. of automotive components) is becoming increasingly important. This paper presents a novel 40 kW (20 kW) power supply unit for hardening/chemical vapor deposition (CVD) plants, as one plant can be used for both hardening and CVD, e.g. for coating cutting tools to increase tool life. The topology and the realization of the IGBT output stage, which has to generate voltage pulses with amplitudes up to 1 kV and a maximum repetition rate of 30 kHz (50 kHz with reduced output power) are described in detail. Furthermore, the construction of the high-frequency power transformer (which is necessary for potential separation) is discussed. Finally, measurement results are shown which also demonstrate the high dv/dt-stress of some system components in case an arc discharge occurs.<<ETX>>


An experimental setup was developed in order to test the detection efficiency of electron emission foils. An electron emission foil is a thin sheet of material which emits electrons when a high energetic particle passes through it. A highly efficient electron emission foil may be feasible if a number of factors are taken into account. The foil material should have a low potential barrier at its surface. The exit surface area of the foil should be made as large as possible. And an electric field can be applied in order to help extract the electrons from the foil. In order to test the efficiency experiment a copper coated kapton foil was incorporated into a parallel plate chamber (PPC) with a 50 μm gas gap size. Two printed circuit boards (PCB) were used as the basis for the PPC. The first was a Next Quad PCB, which was originally designed for use with multiple pixel chips. The second was specifically designed for use with the PPC. The PPC's were irradiated with 5.9 keV photons from a Fe source. The expected exponential behaviour of the gain as the electric field strength increased was found for a Next Quad based PPC. The specifically designed PCB PPC's showed a linear dependence on the electric field strength at high electric field strengths, this behaviour was unexpected and so far unexplained. Both PPC's gain decreased with an increase in the isobutane fraction of an argon isobutane mixture as expected. The gas flow rate in the PPC's was seen to affect the measured gain in the chambers. This was most likely due to poorly controlled experimental conditions. An increase in the gas gap size led to signals appearing at lower electric field strengths. The relation between the current and the electric field strength were compared for a number of specifically designed PCB based PPC's . The electric field strengths at which signals appeared was not identical for all the PPC's. There were a number of unexpected results which have not been explained so far. The construction of the PPC's did not allow the gap size of the PPC to be accurately determined. In order to perform the actual efficiency experiment the unexpected behaviour has to be further investigated. Apart from that the construction process of the PPC's has to be improved in order to improve the accuracy of the gap size. Until these issues are resolved no conclusions can be made about the electron emission foil efficiency.


In order to improve the transmission performance of the wireless power transfer (WPT) system under misaligned conditions, a novel type of dual-channel DDP type transmitter coil is proposed inspired by the traditional LCC compensation circuit and DD coil. The proposed DDP coil is a combination of DD coil and P coil, which jointly establishes the main flux for magnetic coupling and power transmission. At the same time, the P coil also acts as the resonant inductor of the LCC compensation circuit of the WPT system. When the system parameters are well designed, we can achieve relatively more stable output current during the offset of the primary and secondary sides. Experimental results indicate that when the misalignment varies from 0 m to 0.15 m, the output current variation range is 2.92 A to 3.68 A, the current fluctuation rate is 11.5%. Compared with the traditional DD coil with LCC topology, the proposed dual-channel transmitter DDP coil shows better performance in misalignment tolerance.


A numerical approach for assessing the injury risk of fish during turbine passages is introduced. The approach combines computational fluid dynamics (CFD) coupled with the discrete element method (DEM), and extends it with fish behaviour models. The fish behaviour is achieved by an additional force term acting on the particles. Based on ethohydraulic observations three rules of conduct were defined and combined via weighting factors. These rules represent 1) the aim to follow the main flow direction, 2) the instinct of downstream migration, and 3) an avoidance reaction towards moving objects. It is shown that the behavior of the fish surrogates can be actively tuned and adapted. This allows for the expression of both individual and collective behavior with the implementation of instantaneous reactions to the local, unsteady flow conditions in a trade-off with global behavior rules. Therefore, the approach allows for the investigation of a large bandwidth of tasks related to etho- and ecohydraulics and is not limited to the case at hand. In this study, the model is deployed on an example case of a water vortex power plant (WVPP) that allows for the presentation of the general mechanisms and advantages of the method.


Glutathionylation, i.e. formation of mixed disulfides between protein cysteines and glutathione (GSH), is a mechanism by which the redox state of the cell regulates protein functions. Most studies on identification of glutathionylated proteins focused on intracellular proteins. We used a redox proteomic technique based on preloading the cells with biotinylated GSH followed by affinity purification and mass spectrometry to identify glutathionylated proteins in the secretome of macrophages stimulated with lipopolysaccharide (LPS).
We confirmed the LPS-induced secretion of a selected set of proteins: peroxiredoxin (PRDX)1, PRDX2, vimentin (VIM), profilin1 (PFN1) and thioredoxin1 (TXN1). We found that PRDXs are released as glutathionylated dimers; moreover, we were able to confirm that the released TXN1 is glutathionylated. The release of the proteins was inhibited by the anti-inflammatory drug, dexamethasone and by thiol antioxidants GSH derivative GSH-C4 and N-acetylcysteine. We found that PRDX1, 2 and TXN1 are also released by pulmonary epithelial cells infected with influenza virus. For PRDX2, we showed that once released, it stimulated macrophages to release TNF-α acting as a danger signal (1). Proteins released under this specific form of cysteine oxidation may then have immunomudulatory activities. They could be useful as biomarkers of oxidative stress associated with infection or inflammation.


According to the trainning aim of the personnel majoring electr-mechanical engineering,it is helpful to arrange students to participate the construction of experimental program for their creative capability.The program choice,development ideas and procedure management of teaching experiments were studied and practiced,good results were obtained.


Customer relationship management (CRM) is a business philosophy and a strategy for ob-taining and keeping the most valuable relationships with the company's customers. Com-munication with customers wouldn't be missed in well prospering and well running com-pany of the 21st century. The customer is the most important point of a market and when the company doesn't take care of him in attention, he leaves the company to go to the competition. The company that wants to succeed in business should CRM use. I cooperated with Viessmann Ltd.


The fire resistance degree is mainly dependent on the fire resistance performance and fire resistance limit of structure component of the building. So in this paper from the definition and judgement standards of fire resistance limit of structure component the main factors influencing this limit are analyzed, at the same time some common measures are proposed to enhance the fire resistance limit for structure components.


An equivalent circuit for a symmetrical condensed TLM node is presented. The basic circuit has twelve ports and consists of 24 1:1 ideal transformers. Three additional conductances model the conductivity of the medium. The circuit is extended with additional ideal transformers giving six ports for short-circuit and open-circuit stubs which model the permittivity and permeability of the inhomogeneous medium. The scattering matrix of the 18-port network is determined symbolically by solving a set of linear circuit equations. The matrix agrees with previously published results for a symmetrical condensed TLM node, obtained from Maxwell's equations.


Many important bio-molecules, such as proteins and pharmaceuticals, have their natural resonances in the mid-infrared (2 – 30µm) region of the optical spectrum. The primary challenge of sensing these molecules is to increase the interaction between them and light with such long wavelengths. This can be overcome by exploiting optical nano-antennas which can squeeze the optical mode into a volume much smaller than the operating wavelength. We present a novel antenna design based on hybrid materials composed of a coupled Au-SiO2-Au nanorod integrated on the facet of a quantum cascade laser (QCL) operating in the mid-infrared region of the optical spectrum. FDTD simulations showed that for sandwiched dielectric thicknesses within the range of 20 to 30 nm, peak optical intensity at the top of the antenna ends is 4000 times greater than the incident field intensity. The device was fabricated using focused ion beam milling. Apertureless mid-infrared near field optical microscopy (NSOM) showed that the device can generate a spatially confined spot within a nanometric size about 12 times smaller than the operating wavelength. Such high intensity, hot spot locations can be exploited to enhance the photon interaction for bio-molecules for sensing applications.


This consultancy had three main objectives: - to identify fields of common interest for Cdt and Cirad and propose a program of scientific training and visits; - to contribute to the elaboration of the Fircop project; - to give a course on conservation tillage research at Cirad. However, more emphasis was put upon the first and the third items. (Resume d'auteur)


Aerodynamic shape optimization of a helicopter rotor in hover is presented, using compressible CFD as the aerodynamic model. An efficient domain element shape parameterization method is presented which overcomes both the geometry control and volume mesh deformation problems simultaneously. Radial basis function global interpolation is used to provide direct transfer of domain element movements into deformations of the design surface and the CFD volume mesh, which is deformed in a high-quality fashion, and the parameterization method requires very few design variables to allow free-form design. This method is independent of mesh type (structured or unstructured) or size, and optimization independence from the flow solver is achieved by obtaining sensitivity information for an advanced parallel gradient-based algorithm by finite-difference. This has resulted in a flexible and versatile modular method of 'wrap-around' optimization. Previous fixed-wing results have shown that a large proportion of the design space is accessible with the parameterization method and heavily constrained drag optimization has shown that significant improvements over existing designs can be achieved. In the present work, the method is extended to a rotor blade, and this is optimized for minimum torque in hovering flight with rigid constraints on thrust, internal volume and pitching moments. Twist optimization results are presented for three tip Mach numbers, and the effects of different parameterization levels analysed, using various combinations of two levels; global and local. Torque reductions of over 12% are shown for a fully subsonic case, and over 24% for a transonic case, using only three global and 15 local twist parameters.


As such, the plain assertion that in all societies there is an inseparable interrelation between law and its respective institutional, social and political context is as fashionable as it is self-evident and unoriginal: a vague declaration of principle which is easily applicable to any society and legal system, classical Greek or Roman, "primitive" or modern. However, the contributors to this volume of detailed case studies and problem analyses do not simply take this assertion as a non-committal starting-point for yet another series of old-style academic seminar papers on the law and the process of law in fifthand fourth-century democratic Athens. They attempt to take it seriously on several levels and in a variety of different ways. Not only do they set out to elucidate the specific closeness and complexity of the relationship between law, legal institutions and procedures and the particular internal structure of that unique social and political entity which made up Athenian democracy in its heyday. Not only do they try to explore in detail the interplay between general ideas about, and prevailing attitudes towards, law and justice, the code of accepted and acceptable behaviour, the set of norms and social values, the civic ideology and collective mentalite of the Athenian citizen community on the one hand; and the concrete application of rules and norms, the actual administration of law, the day-to-day working of the courts and their procedures on the other. In the process, several contributors to this volume also, as it were, go out of their way explicitly to spell out and take on the theoretical implications, methodological consequences and challenges that such an ambitious programme necessarily entails.


The electrical, magnetic, and optical properties of charge-transfer salts containing tetrathiafulvalene (TTF) and the pseudohalides, thiocyanate (SCN) and selenocyanate (SeCN), have been investigated. These salts are quasi-one-dimensional compounds containing cation radicals only, in contrast to a cation-radical-anion-radical system, such as tetrathiafulvalene tetracyanoquinodimethane (TTF) (TCNQ). Measurements of electrical conductivity, thermoelectric power, and optical reflectivity of single crystals of the nonstoichiometric salts (TTF)12(SCN)7 and (TTF)12(SeCN)7 show metal-like characteristics above 200 K (high-temperature region). The conductivities at room temperature are approximately 750 mho/cm comparable to those found in (TTF) (TCNQ), and increase with decreasing temperature down to approximately 200 K. The thermoelectric power at room temperature is small and positive (approximately 9 microvolts/deg K), and decreases linearly with decreasing temperature in this region (as expected for metal-like hole conduction along the TTF chains). The ESR intensity, however, decreases with decreasing temperature above 200 K. At 170 K a metal-nonmetal transition occurs, and the transport and magnetic properties below this temperature are characteristic of a semiconducting state.


The 37 earthquakes with complete 3-component records are selected from the acceleration data of the mainshocks and the aftershocks recorded by Xinjiang seismic network;Their magnitudes are between 1. 8 and 6. 8,and epicentral distances are within 100 km(only one or two are more than 100 km). Based on the expression of the relation among focal peak value,acceleration and environmental shear stress field, the environmental shear stress values in South Tianshan,Xinjiang are calculated. The result shows that the mean shear stress values are relatively high in this area,which is concerned with the special tectonic setting of Xinjiang.


One of the most important benefits that WiMAX technology brings, the ability to provide differentiated quality of service (QoS) guarantees, could also prove to be the largest problem for system designers, because scheduling mechanisms able to cope with these demands have not been explicitly defined in the standard. In order to facilitate the understanding of how various scheduling schemes perform in a real system, we present here a detailed performance evaluation of some utility-based scheduling algorithms, covering aspects like fairness and QoS provisioning. Through a series of extensive simulations, we analyse the ability of the scheduling schemes considered to strike a balance between fairness among users, or more restrictively, user QoS requirement satisfaction, and system efficiency maximization. Further, we show how several simple algorithms could be used as building blocks, constructing a powerful mechanism that allows the system designer to obtain any desired system behaviour, or even to dynamically change from one profile to another, depending on specific network-related conditions. More specifically, by combining the benefits of proportional fair (PF) scheduling with the highly desirable system capacity maximization, and also taking into account a peak-to-average (PTA) channel quality metric, we are able to define a rule that outperforms traditional scheduling schemes, copes with various network conditions and provides graceful service degradation. Our results indicate that, by exploiting the intrinsic properties of orthogonal frequency division multiple access (OFDMA) as well as the mechanisms of the WiMAX system that are not regulated by the standard, one could increase the system efficiency, while fully respecting the QoS guarantees imposed. The use of algorithms that provide graceful performance degradation is highly advisable, in order to be able to employ a non-conservative call admission control (CAC) mechanism, which further improves the overall spectral efficiency by maintaining the system close to saturation at all times.


This document discusses the concept of research excellence: what it is, how it can be assessed and why it matters. Our context for this discussion is the Research, Science and Innovation (RSI) sector of Aotearoa New Zealand (NZ). Consequently, we start with the approach used by the Ministry of Business, Innovation & Employment (MBIE), which administers Vote Business, Science and Innovation. MBIE uses the definition in the National Statement of Science Investment: 2015-2025 ( NSSI ). We then discuss definitions and assessment in other New Zealand funding agents and organizations (e.g


Objective:To study podophyllotoxin in Dysosma genus that come from diffirent spicies or diffirent arears of Guizhou province,which provide the basis of rational use of Dysosma genus.Method:RP-HPLC method,Diamonsil C18(4.6 mm×150 mm,5 μm)column was adopted,the mobile phase consisted of methanol-water(55∶45) with flow rate of 1 mL·min-1,and the detector wavelength was 207 nm.Result:The calibration curve was linear relationship in the range of 0.32-1.61 μg(r=0.9999).The average recovery rate(n=6)was 102.1%,RSD was 0.8%.Conclusion:The podophyllotoxin in Dysosma genus of diffirent spicies or diffirent arrears has significant difference.


Due to an increase in industrialization, there is a notable decrease in agricultural farmland. Human population is increasing in day to day life which in turn increases the demand for food. Food is the primary basic source for the survival of human being on earth. Usually, traditional planting with soil consumes longer time. Nowadays there is a huge technology advancement in the agriculture sector with the hydroponic concept. Growing a plant without soil helps to increase the yield of crops in short duration for any climatic condition. From this idea pest and weed can be controlled and labor cost is reduced. A survey about technology and techniques are discussed to collect a review on automatic monitoring of hydroponics farms using IoT.


This article focuses on the value of weather information systems. It first gives an overview of the meteorological community and its data- collecting operations. The article then reviews existing and completed weather-related studies and projects. Emphasis is on Road Weather Information Systems (RWIS).


Tourism development is a factor of national security. Particularly, this is linked to the active distribution of information on territories, which influences on their geopolitical, investment and cultural attractiveness. The objective of the present work is analysis of identity of the tourism destinations of Russia with regard to their functioning for the purposes of the national security. The identity of tourist destination means sharp appearance of its characteristic features making it recognizable now or in the future. The identity of destination is relevant to the national security because of three main causes: mass recognition of a country or region permits them to strengthen positioning in the world; the identity is a tool of conservation of unique national and regional features under the conditions of globalization; outside interest to a territory through identity facilitates increasing value of its natural and historical-cultural heritage. The present work deals with analysis of names of collective accommodation facilities (hotels, hostels) bearing identity in the particular regions and cities of Russia. It is established that these names taken entirely do not contribute to the identity of the relevant destinations in all cases. The portion of those, which, in contrast, bear regional or national identity is usually relatively moderate. This is a challenge for the national security, which is as big as the latter should be provided by the industry of tourism and hospitallity. The solution of this problem is possible via successful, but well-balanced actions of administrative bodies and business society aimed at support of initiatives leading to increase in the identity of the Russian destinations.


. In this study, a sensitivity analysis is implemented using response surface strategies to control the Walters-B nano(cid:13)uid stagnant point (cid:13)ow caused by a Riga surface. An electromagnetic actuator is known as Riga surface. The Buongiorno model is used to construct the mathematical model that includes a Newtonian heating condition as well as radiation e(cid:11)ects. Based on the fundamental laws of mass, momentum


The response of IOP in the normotensive human eye to Neodym‐YAG‐laser iridotomy was investigated in this study. In 2 series of 10 patients, each unilateral laser iridotomy was performed with a YAG‐laser prior to cataract surgery. In one group laser iridotomy was done without pre‐treatment, in the second group laser iridotomy was preceded by treatment with 1% pilocarpine. Close follow‐up of IOP before and after surgery was carried out with the Non‐Contact‐Tonometer. Laser iridotomy caused average IOP rises of 10 mmHg, which could be identified as early as 20 min after surgery, with a maximum of response after 80 min, and a declining IOP from 100 min post‐operatively onwards. Pre‐treatment with pilocarpine eyedrops could be reduce the laser‐mediated IOP rise to less than one fourth. These results recommend a mild miotic for routine pre‐treatment for iris laser surgery in order to cope with acute pressure rise as one of the major problems in these procedures.


The present paper reports the results of a Monte Carlo experiment using a turbulent channel flow. Different actions are proposed, varying the size, duration and sign of a localised volumetric force that acts near one wall of a turbulent channel flow, running at a small Reynolds (ReT = 165) in a small computational domain. The effect of each action is evaluated comparing the evolution of the flow with and without the action, gathering statistics over 1700 repetitions of the experiment for each action. The analysis of the results show that small/short forcings are equally likely to increase or decrease the skin friction drag, independently of the sign of the forcing (i.e., towards or away from the wall). When the size or the duration of the forcing increases, so does the probability of increasing the skin friction. Then, an a priori analysis is performed, evaluating the state of the flow just before the action, conditioned to actions that result in a decrease of the skin friction over a period of one eddy turn-over time. The resulting fields of velocity, wall shear stresses and wall pressure are consistent with an opposition control strategy, where the forcing is opposing the vertical motions near the wall. Finally, a preliminary analysis of the performance of actuation triggered by pressure or wall shear stresses sensors is evaluated (i.e., a posteriori analysis). Our results show that the actuation triggered by a wall shear sensor seems to be more effective than the actuation triggered by a wall pressure sensor, at least for the preliminary definitions of sensors and thresholds used here.


The gravitational attraction of planets can cause significant perturbation of the trajectories of meteoroids. The resulting deflection can result in significant enhancement of the flux of meteoric particles in the neighbourhood of the planet. We give an analytical method for calculating the relative flux of stream meteoroids in the vicinity of a planet. We include the effect of shielding of certain regions that are not accessible to the meteoroids that have impacted the planet. We compare our results with those of Divine et al. and although we confirm the accuracy of their trajectory equations, the fluxes predicted by their calculations are not consistent with integrated fluxes over a planet predicted by the classic work of Opik. Our method yields predictions for the integrated flux enhancement factor that are identical to Opik's. We present the results of these calculations and find that in all cases, tail-like regions of enhanced meteoroid flux appear downstream of the planet, with very large enhancements possible in the case of the giant planets for all probable stream velocities.


Yellowtail flounder Pleuronectes ferrugineus (Storer) have been identified as a potential species for coldwater aquaculture along the north-east coast of Canada. It has been shown that increased photoperiods improve growth and survival during the larval stage of this species. We conducted two experiments to determine the effect of photoperiod on the growth and survival of juveniles. The first experiment compared growth and survival under 24-, 18- and 12-h lighting per day with a restricted food ration. The second experiment compared growth and survival rates under the above photoperiods and ambient lighting with fish being fed to satiation. No significant differences in growth or survival were found in juveniles under the different photoperiods in either experiment.


Let A be the Steenrod algebra and D (V ) the Dickson algebra. An ordering in D (V ) is de…ned according to the Steenrod algebra action. Using this ordering, we prove the following: Let f 2 EndA (D (V )) be an A-linear degree preserving map. If f is non-zero on the lowest degree, then f is an isomorphism. Moreover, EndA D (V ) is a local ring, where D (V ) is its augmentation ideal. 1. Statement of results It is known that the classical Dickson algebra Dk is a polynomial algebra: Dk = Fp[d1; :::; dk] Mùi related Dk (for p = 2) with the dual of the Dyer-Lashof algebra calculated by Madsen. Motivated by topological questions regarding the cohomology of an in…nite (…nite) loop space and in‡uenced by the work of Campbell, Cohen, Peterson and Selick in [2] and [3] we study the problem under which conditions is an A-endomorphism of D (V ) := (H (V ))p an isomorphism. Here A stands for the Steenrod algebra. Firstly, we consider the classical Dickson algebraDk. Where modi…cations are needed between the case p = 2 and p > 2 they are provided. Given a sequence of k non-negative integers n = (nk; n1; :::; nk 1) let 2000 Mathematics Subject Classi…cation. Primary 55S10, 13A50; Secondary 55S12, 55P47, 13H05. Key words and phrases. Dickson algebra, Steenrod algebra, Isomorphisms of Dickson algebras, Local rings. This paper is in …nal form and no version of it will be submitted for publication elsewhere. 1 2 NONDAS E. KECHAGIAS


Aim: The LLLT was found to recover NIHL and ototoxicity induced hearing loss in rats but the optimal LLLT laser dosage to treat NIHL needs to be determined. The aim of this study was to find the optimal laser dosage to recover a NIHL with transmeatal-LLLT. Methods: Bilateral ears of rats were exposed to noise (narrow band noise, 120 dB, 16 kHz, 6 h). Left ears of the rats were irradiated with transmeatal-LLLT (830 nm) of 50, 100, 150, 200, 250, 300 mW for 60 minutes per day for 12 days, starting 1 day post induction of NIHL. Right ears were not irradiated and used as control ears. The hearing levels were measured at each frequency of 8, 12, and 32 kHz before the noise exposure, 1, 3, 8, and 12 days post noise exposure. The differences of hearing levels between left treated ear and right controlled ear at each frequency of different laser dosages (50 – 300 mW) were compared to see the most effective laser dosages to treat NIHL. Results: Hearing levels were most improved by 150 mW, slightly improved by 200 mW, not improved by 50 and 250 mW, and became worse by 300 mW. Conclusion: The results of this study suggest that most effective therapeutic laser dosage window to treat NIHL with transmeatal-LLLT was 150 mW for 12 days and it was not effective by 50, 250, and 300 mW.


We set the treatment of some element absent on the base of balanced fertilization to investigate the effect of each element on the yield of maize and the absorption character and their recycling in plant.The result showed:comparing with the optimum treatment,the yield of each treatment all decreased.The treatment of no fertilization was the worst,followed by the treatments of no nitrogen and no phosphorus,the treatment of no potassium and no zinc followed.Seedling stage to tasseling stage and tasseling stage to maturity stage were the absorption fastigium to plant.The experiment of the absorption of nutrition and balanced coefficient showed that the input and output of nitrogen was about balance,phosphorus was excessive for high yield and the input of potassium was not enough.


The hot-atom method has been used with tritiated phenyl cations and organic phosphines to synthesize tritiated mixed methyl-phenyl onium derivatives of phosphorus. The replacement of phenyl groups by various numbers of methyl ones in the initial phosphines and correspondingly in the phosphonium compounds has provided a means of examining the effects of stearic and electronic factors on the formation of organic onium phosphorus derivatives. The yields are given for the phosphonium derivatives produced by heterolytic decomposition of labeled diphenyl; the relative reactivities of the phosphines have been determined together with the stabilities of the substituted phosphonium cations.


Emerging markets are becoming a popular destination for private equity (PE) investments from around the world, including investments originated in both advanced economies and other emerging markets...


Support column on a vehicle body frame of a bus, with each having at least a body element is connected at opposite ends and an extending between the two ends of the hollow profile member (2), characterized in that the hollow profile element (2) is in one piece and has a longitudinal central axis, which is curved or has at least two non-parallel sections and that connect to the opposite ends of outer column sections between which a middle pillar portion is provided, which has in at least one direction of stress over a larger moment of resistance against bending than the outer column sections, wherein the hollow profile element (2) in the region of the central column section has a S-lay or two kinks.


The paper compared and analyzed the"5+1 regions"allocation and"custom transfer allocation". Meanwhile it points out the advantages and the improvement of"5+1 regions"allocation, comparing with"custom transfer allocation". What's more, it can be taken as the reference to the goods allocation and collective customs clearance among the special districts.


We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart.


First line of text: I have found a treasure, worth far more than gold. -- First line of chorus: Little blue diamonds heaven sent to me. -- For voice and piano. -- Caption title. -- Advertising includes musical incipits. -- Cover illustration by Starmer. -- Cover includes two photographs of Miss "Jackie" Saunders and Baby Jacqueline.


CERT-EU's mission is to enhance the security of the information and communications technology infrastructure of the EU institutions, bodies and agencies (its 'constituents'). It supports incident prevention, detection, mitigation and response by acting as the cyber-security information exchange and incident response coordination hub for its constituents. It is based in Brussels. Collecting and managing cyber threat information and using it in the detection infrastructure is key in risk mitigation strategies. Information exchange with external and internal partners is crucially important to realize the potential added value. CERT-EU actively and intensively engages in cooperation and partnerships with its peers and partners in the IT community and as such it is recognised as a leading player in information exchange, both on the theoretical level as in its real world implementation. CERT-EU has also made important advances in the way it exchanges information with its constituents to make the information actionable, relevant, useful and specific and to avoid as much noise and false positives as possible. A good understanding of the specific threats at any given moment increases the chances of mitigation. An organization may be more concerned by cyber-threats targeting its sector, its supply chain or its geographical area and it may handle in priority cyber-threats potentially causing the most damage, being the most persistent or having a specific motivation. Monitoring these aspects and acting accordingly allows organizations to mitigate the threats that are the most pertinent at a given time. As cyber threat information sharing matures, it is necessary to consider how it should be optimized and what it should deliver on the consuming end. This implies that information exchange should meet minimal quality criteria in terms of contextualization, timeliness and actionability. Faced with an extremely dynamic cyber-threat landscape, the challenge is also to automate information sharing and make it immediately actionable. But in addition, the process should also include escalation and alerting functions to trigger immediate attention to the most severe of threats. The talk will highlight the insights derived from CERT-EU practical experience in the past few years, presenting concrete success factors for cyber threat information exchange. It will also highlight some remaining challenges and unresolved problems.


The following problem is considered: For a given (measured) vector l, a vector v is sought such that A(l+v)+By=w for some unknown y and v T v=min (matrices A, B and the vector w are given). Further, it is assumed that the system of equations has a partitioned form A j (l+v)+B j y=w j , j=1,···,n. Formulas for solutions are given, also in the partitioned form along with a multistage numerical algorithm.


The invention discloses an electromagnetic shielding material comprising the components in percent by volume: 85-92 percent of conductive particle, 5-10 percent of conductive adhesive and 3-5 percent of antioxidant. The electromagnetic shielding material has favorable reusability and electric conductivity.


Modelling fertility patterns of a population has gained popularity among the demographers in recent years. This article investigates the fertility patterns of Pakistan and its urban and rural regions. The analysis of age specific fertility rates (ASFRs) has demonstrated high fertility in rural population as compared to urban and overall Pakistan population during the period 1984-2007. Substantial respective decreases of 44.98%, 48.72% and 46.76% in total fertility rates (TFRs) of rural, urban and overall Pakistan have been observed during the past 23 years. Two parametric models, viz., Hadwiger function (Hadwiger, 1940) and Peristera and Kostaki model (Peristera and Kostaki, 2007) were used to model the ASFRs of rural, urban and overall Pakistan during the year 2007. The models used in this study have canonical demographic interpretation whereas the previous endeavors used to analyze the ASFRs of Pakistan were lacking this important aspect (Nasir et al., 2009). Using model selection criteria (Montgomery et al., 2012), the Peristera and Kostaki model (Peristera and Kostaki, 2007) was found parsimonious to model the ASFRs of Pakistan where the estimated coefficients have practical demographic interpretation.


Influence of salt stress on microflora and enzymes activities in vegetable soil was studied through artificially adding simulated composites salt(SCS) into natural vegetable soil.The SCS was designed according to components of the saline soil in Shanghai,which comprised 14.6% Ca2+,7.9% Na+,4.0% Mg2+,45.4% NO-3,16.0% SO2-4,12.1% Cl-.Compared with the control,bacteria amount decreased,but actinomycete increased in all four different salt-enhanced soils(1,5,10,20 g·kg-1) at all five testing intervals.In additions,fungi rose up in all the salt-enhanced soils at 15th day,and then dropped down at 30th,45th and 70th day.The ratio of bacteria/microorganisms-cultured in soil(MCS) decreased and that of fungi/MCS increased.There were negative correlation between the activities of four enzymes(urease,protease,invertase and catalase) and salt content except for invertase,catalase under the low salt stress(1 g·kg-1).Correlation analysis indicated that the activities of soil urease,protease,invertase and catalase were highly negative linear correlation with salt content in vegetable soil.Especially,the correlations between protease and invertase were high and stable,and the coefficients were between-0.930 and-0.997.


War — Meaning and Existence of — United Nations Enforcement Action in Korea — Suppression of Armed Insurgency in Malaya.


Abstract : The bulging of metal ammunition boxes containing 1-1/2 illuminating Flare Cartridges has been investigated. The defect occurred during storage of flares manufactured in 1976-78 and was found to be due to the entry of moisture into the magnesium based flare composition resulting in the generation of hydrogen. The stores were so adversely affected that MRL recommended that they be destroyed.


This work reports on the fine structure and histochemistry of several regions of the alimentary canal in Pholoe minuta (Fabricius, 1780). Particular emphasis is placed on the elaborate secretory cells (tryptophan-containing secretion) associated with the pharyngeal jaws. Mucus gland cells were located and described for the oesophagus (acid mucins), pharynx papillae (sulphated acid mucins), pharynx luminal lining (mixed acid mucins) and the intestine (mixed acid mucins). Enzymic gland cells (zymogen-like secretory granules) were identified in the luminal lining of the pharynx and in the intestine. Lysosome-containing cells (presumably absorptive) were described in the intestine. Glycogen reserves were observed along the coelomic peritoneum and a seasonal pattern for their deposition and utilization is briefly discussed.


The invention relates to the technical field of heterocyclic chemistry, especially relates to a condensed ring system containing oxygen atoms as the only heterocycle atoms, concretely discloses a preparation method of a Darunavir intermediate. The method comprises the following steps: obtaining a compound of formula (3) by using (3R,3aS,6aR)-hexahydro-furo[2,3-b]furan-3-ol as a raw material to react with triphosgene under alkaline conditions, then directly reacting with a compound of formula (7) to obtain a compound of formula (8); or obtaining a compound of formula (3) to react with an N-hydroxyl compound to prepare active ester, and then reacting with the compound of formula (7) to obtain the compound of formula (8).


Cleland, C., Hunter, R., Murtagh, B., Sengupta, U., Tully, M., Kee, F., Moutinho Barbosa de Melo, S., Hino, A., Florindo, A., Duarte, F., Alberico, C., Lopes, A., Reis, R., & Ellis, G. (2016). Healthy Urban Living and Ageing in Place (HULAP):Physical activity, built environment and knowledge exchange in Brazilian cities: Study Protocol. Poster session presented at WHO HEPA Europe 2016, Belfast, United Kingdom.


The invention relates to a method for the treatment of pollutants, especially acid sludge, contaminated soil material, in which the pollutants are brought into contact with a treatment agent, said treatment agent containing a paper lime.


Abstract This study holds that negation phenomena in a natural language involve much more than mere logical entailments in some individual's epistemic model. The unique characteristics of negation, i.e., the persistent diachronic renewal of negative particles cross-linguistically, as well as the prevalent synchronic reinforcement of these particles through emphatic mechanisms, demand an analysis that casts the expressive speaker, not her epistemic model, in the leading role. Opting for a comprehensive account of negation in Modern Greek, the present analysis highlights this subjective involvement of the individual and suggests that it is the thinking and – more important – the feeling speaker that directs the distribution of Modern Greek negators.


A computational grid is a widespread computing environment that provides huge computational power for large-scale distributed applications. One of the most important issues in such an environment is resource management. Task assignment as a part of resource management has a considerable effect on the grid middleware performance. In grid computing, task execution time is dependent on the machine to which it is assigned, and task precedence constraints are represented by a directed acyclic graph. This paper proposes a hybrid assignment strategy of dependent tasks in Grids which integrate static and dynamic assignment technologies. Grid computing is considered a set of clusters formed by a set of computing elements and a cluster manager. The main objective is to arrive at a method of task assignment that could achieve minimum response time and reduce the transfer cost, inducing by the tasks transfer respecting the dependency constraints.


An accurate modeling of flow path connectivity is critical to reservoir flow performance prediction. Flow path connectivity is controlled by the complex shape, extent and spatial relationships between pay intervals, their intersection with wells, and the existence of flow barriers between wells. These features can be represented in three different scales of reservoir modeling variables: the large scale facies object, the mid-scale effective property at the cell-center (porosity and permeability), and the extremely fine-scale consisting of thin flow barriers that cannot be accurately represented in current high-resolution pixel-based models. To preserve these important fine-scale geological features at the flow simulation block scale, we propose introducing an additional modeling variable as the edge of a model cell. This cell edge is a continuous or categorical value associated with the cell face and is defined in conjunction with the cell centered property which is often reserved for facies types and/or petrophysical properties. The edge property is modeled in conjunction with the pixel-based facies to preserve the correct spatial associations with the large scale facies objects during upscaling and history-matching. For the flow simulation model, the edge properties are easily translated into transmissibility multipliers. Using the example of 3D shale-drapes attached to channel-sand bodies in a turbidite environment, we show how such shale drapes can be accurately upscaled and history matched to production data while maintaining the geological concept that describes the drape geometry. The perturbation parameter in history matching is the continuity of the shales as the edge property. More generally, we show how this coupled modeling of cellcenter and cell-edge allows for more flexible reservoir modeling, opening up the potential for modeling and history matching complex geological features effectively at the scale that they are relevant, without additional computational cost of flow simulation.


This is a report of creative and technical considerations in building a participatory sound performance The SINE WAVE ORCHESTRA stay. In this performance, the participants one by one leave their own sine wave in the performance space. These sine waves form a mutually interfering sound space while the sound field of a room changes during the performance.


A three-judge panel of the 8th U.S. Circuit Court of Appeals ruled that procreation is not a major life activity and therefore is not protected under the Americans with Disabilities Act (ADA). A number of lawsuits alleging HIV-related discrimination have been based on the notion that a person with the virus cannot engage in acts of reproduction. Specifically, a hospital employee contended that the Iowa Methodist Medical Center's refusal to provide fertility treatments in its self-insured health-care benefits program violated the Americans with Disabilities Act (ADA) and the Employee Retirement Income Security Act. The employee referred unsuccessfully to a Northern District of Illinois ruling that reproduction was a major life activity because the reproductive system was included among systems that can have an ADA impairment. The employee's attorney believes this ruling will have negative consequences for people with HIV who have no symptoms that limit work or other activities.


We review definitions of optical resolution and how they relate to the Instrument Transfer Function of surface profiling interferometers. The corresponding optical cutoff provides a selection criterion for a given metrology application (PSD, waviness).


The invention provides an intelligent early education system, a client side and a data processing method. The intelligent early education system comprises a first client side, a cloud server and a second client side and is characterized in that according to the configuration of the first client side, a selection instruction input by a user of the first client side is sent to the cloud server, and the cloud server obtains corresponding service data according to the selection instruction; according to the configuration of the cloud server, the selection instruction is received, the corresponding service data are obtained according to the selection instruction, and task information is formed by the service data, sent to the second client side and composed of one or more service data; according to the configuration of the second client side, the task information is received to be used by the user of the second client side. According to the intelligent early education system, the service data can be obtained in a more targeted mode, the task information more suitable for being used by the user of the second client side is generated, and the pertinence and setting performance of the task information are improved.


Metastructures hold promises for the realization of novel optical functions. Common topologies utilized in the form of metasurfaces featuring simple periodicities, however, are not exploiting the f...


Background : Pediatric anesthetists were surveyed regarding their anesthesia management of a screaming child with a penetrating eye injury. The results are reviewed in relation to the available evidence in the literature.


The purpose of this article is to get some possibilities of environment consciousness and ethics for Korean churches through the experiences of African Independent Churches. Mission churches and AICs are the two primary ecclesial contexts in which African initiative has occurred. Mission churches are those that have evolved from the outreach of Western denominations and still represent the collegial traditions concerned. African Initiated Churches are the churches begun by Africans in Africa primarily for African. In fact, As regards the African Initiated Churches, Missionary genius, missionary methods and missiological significance of AICs have not been studies in depth. Christian mission deals with the outreach of Christian faith and life in the extension of Christ`s good news beyond the boundaries of ignorance, cultures, poverty, suffering or whatever obstacles obscure a clear Christian witness in the world. In AICs, the interpretation of a prophetic healing ministry is inevitably very wide. Illness was viewed not only as individual psychosomatic afflictions but also as sociopolitical conflicts and crises which had to be resolved in terms of very real perception of God`s expanding kingdom. So we can say that the church liberating humankind from poverty and deprivation and the church healing an abused earth are integrally linked in the AICs. In short, the prophetic churches`s ministry of healing quite naturally came to be extended to buring social and political issues in AICs` ecclesiology. Some AICs have a close identification of Christ`s body with the abused and barren soil make sense, Traditionally the ancestral guardians of the land belonged to the soil and In Africa context, Christ is both guardian and the soil itself. New conceptions of Christ`s lordship and his salvation of all creation can develop from this essentially African express of his pervading presence in the cosmos.


Brinjal ( Solanum melongena L.), also known as eggplant, is commercially important solanaceous vegetable crop of Indian subcontinent. Rich variability exist for both cultivated type and its wild species in the country. It is popular among people of all social strata and hence, it is rightly called as vegetable of masses (Patel and Sarnaik, 2003). Hybrid vigour in brinjal was probably first reported by Nagai and Kida (1926) across combinations of some Japanese varieties of brinjal. With increasing popularity of F 1 hybrids in eggplant, it is imperative to obtain hybrids having excellent quality coupled with high yields. To obtain high yield per unit area, exploitation of hybrid vigour is one of the good way and particularly in crop like brinjal, whereas more seeds per fruit are obtained of hybrid brinjal. The common approach of selecting parents on the basis of per se performance does not necessarily lead to fruitful results but it provides to the breeders an insight in to nature and relative magnitude of fixable and non-fixable genetic variances. In this context, the present investigation was under taken to identify potential parental combination in order to have superior hybrids and extent of heterosis in F 1 hybrid over better and mid parent in a diallel cross set of 7 parents.


Growing processing tomatoes represents one of the most intensive forms of land use in terms of water consumption and nutrient inputs. During the last decade in many European countries and in the United States, Integrated Crop Management guidelines have also been applied for fertilisation and reducing nitrogen inputs to crops has become compulsory. A large number of Best Management Practices, rules and tools have been developed to steer farmers toward sustainable farming practices. High-input crops, of which the processing tomato is one of the most important, now have to face new worldwide emergencies: water shortages and desertification. Moreover, consumers demand certified food quality and safety, nutraceutic foods and environmentally friendly production. Market and policies have changed. In this new context both farmers and industries must focus on a rational use of natural resources: preserving water and soil fertility will be part of a product's new quality labels. ICM strategies must be applied and improved if these goals are to be reached. ICM improvement requires, above all, profound changes in technical/social/economic perspectives: ○ Water and nutrient inputs must be no longer reasoned in terms of quantity but in terms of their efficiency in achieving a precise target (e.g. °Brix Water or Nitrogen Use Efficiency as °Brix kg ha -1 mm -1 or kg -1 N) ○ Nutrient supplies (amount and timing) must be based on the crop energy/biomass conversion ratio, not on the predicted yield ○ Physical and physiological-based DSS, rather than simplified approaches (tables, checkbook methods, etc.), must be incorporated into ICM ○ Extensive learning and Information Technology diffusion programs must be activated ○ Environmental laws reduce crop profitability: society must accept the responsibility of rewarding farmers for their role in safeguarding clean water, fresh air and bio-diversity ○ An integrated Production Chain approach is needed to correctly manage water and soil resources ○ Non-conventional water and nutrient sources (brackish and reused water, compost) should be taken into account The amount of water needed to produce 1 ton of peeled tomatoes decreases by 14.7 % if ICM rules are applied at a farm level only and by 19.3% if water use is optimised throughout the production chain. Applying improved ICM strategies which enhance water and nutrient efficiency could bring estimated water savings of about 25%.


This article is an analysis of the corpus of knowledge relating to medical care in schools, based on the work of its most significant exponent. It traces the development of this subject from the second half of the nineteenth century when it took on institutional status, to the rise of the republic. The article identifies and puts into perspective the attitudes expressed by doctors, teachers, psychologists, pediatricians and other child specialists over the course of this period. It also explores other indicators of its institutional status such as congresses held, scientific societies and scientific journals dealing with this subject. The study centers on the situation in Spain but makes reference to the international context in so far as it influenced the Spanish approach.


The deformation behavior during tension of titanium GRADE 2 and steel 3723HR samples is investigated. The distribution of localized plasticity foci in the near-surface layers of samples of two materials is studied. A correlation between the stages on deformation curves and evolution patterns of spatial localized plasticity foci on titanium alloy GRADE 2 and steel 3723HR is established. It is established that a different type of deformation diagrams σ=f (ε)) during tension of metallic materials is manifested in the different distribution character of deformation fields at different stages of the deformation curve.


This study investigates the tax efficiency of actively managed equity funds by conducting a previously unaddressed natural experiment. Specifically, we examine whether asset sales were timed to take advantage of the introduction of a substantial discount to realized capital gains when the holding period was at least one year. Institutional equity fund management in Australia is principally focused on the pre-fee and pre-tax performance surveys of leading asset consultants. Given this industry setting, our study is important because tax efficiency is not accounted for directly in the reported performance numbers, and is thus opaque. We find that active fund managers overall have significantly increased the proportion of long-term capital gains realized after the change in taxation code, although there are significant variations across funds. We also find that active fund managers realize more long-term gains on both large capitalization and low volatility stocks.


Let $\MCZK$, denote the multiplier algebra over $\CZK$, the algebra of continuous functions into the compact operators with spectrum the infinite product of two-spheres. We consider multiplier projections in $\MCZK$ of a certain diagonal form. We show that, while for each multiplier projection $Q$ of the special form, we have that $Q(x)\in\BH\setminus \KK$ for all $x\in \prod_{j=1}^\infty S^2$, the ideal generated by $Q$ in $\MCZK$ might be proper. We further show that the ideal generated by a multiplier projection of the special form is proper if and only if the projection is stably finite.


1. A method, comprising: obtaining a set of magnetic resonance data partially parallel imaging (MR-PPI) with incomplete sample utilizing a plurality of RF receiver coils (14); irekonstruiruyut dataset MR-PPI with partial sample to generate the reconstructed magnetic resonance (MR) images, wherein the reconstructing includes the steps of: (i) apply operator generalized partially parallel data collection autocalibration (GRAPPA) or direct convolution to to fill at least some of the missing data set of MR-PPI data from incomplete sample thereby to form an enlarged set of data comprising a data set of MR-PPI with incomplete sample and missing data Restores s by the operation (i), and (ii) use an algorithm different from GRAPPA operator and distinct from the direct convolution to reconstruct the enlarged data set, or to reconstruct the data set of MR-PPI with incomplete sample using a larger set of data as a set of initialization data for the iterative algorithm rekonstruktsii.2. A method according to claim 1, wherein:. Obtaining comprises the step of obtaining the data set of MR-PPI with incomplete sample, comprising a central region k-space including k = 0, where the sample is not incomplete, intermediate region k-space surrounding the central region k-space sampling which is incomplete with a first acceleration coefficient R1, and an outer region k-space surrounding the intermediate region of k-space, wherein the sample is incomplete with a second acceleration factor R2, where R2> R1.3. spo


Purpose To report on the outcome of surgical submacular choroidal neovascular membrane (CNV) removal in children and to perform a comprehensive review of literature concerning this intervention in children. Methods In this retrospective, noncomparative, interventional case series, we included 8 eyes of 7 consecutive children with subfoveal choroidal neovascularization treated by pars plana vitrectomy (PPV) and CNV removal. Main outcome measures were visual acuity and complications. Results Mean age at surgery was 8.6 ± 5.2 years (range: 2–16). Two out of 8 eyes were idiopathic. Corrected-distance visual acuity (CDVA) improved from 1.01 ± 0.45logMAR (range:0.3–1.5) at presentation to 0.60 ± 0.37 (range:0–1) at last follow-up (p = 0.03). Mean follow-up was 3.9 ± 3.9 years. Six eyes received at least one intravitreal injection of bevacizumab prior to surgery. Recurrence occurred in one eye with Best's disease. Literature review revealed a total of 42 cases with the most frequent etiologies being Presumed ocular histoplasmosis syndrome (POHS) and idiopathic CNV. Considering all cases together, mean CDVA improved from 1.00 ± 0.37logMAR to 0.52 ± 0.42 (p < 0.01). CNV recurrence occurred in 11 eyes (22.0%), 7 of which had an inflammatory etiology. Other complications included pigment epithelium tear, atrophy and retinal tear. Conclusion Surgical removal of CNV is a viable, effective and safe option in children with persistent submacular neovascular membranes.


In Hong Kong, >80% of patients with cardiovascular disease are diagnosed with coronary heart disease (CHD), and the incidence is increasing in middleaged adults (age >40 years).1 Preventive strategies (such as physical activities, healthy dietary choices, and quitting smoking) are effective approaches to reduce modifiable cardiovascular risk factors. Webbased and technology-supported programmes have contributed to the improvement in exercise adherence and outcomes.2-5 These programmes are effective if delivered individually by telecommunication for support and an enhanced interactive approach. In view of the advantages of e-health programmes and the widespread use of the internet, as well as a growing number of young patients with CHD, an interactive e-health educational intervention (e-HEI) was developed.


It is a well-known fact that mass media tools have tremendous impact on people all around the world, and it is also becoming a significantly important research area for scholars, educators and researchers in applied linguistics. EFL students in Turkish context complain about their speaking skills in English despite their exposure to English for a long period of primary and secondary education. Knowing this fact as a member of this community, an exploratory practice was conducted as a pilot study to find out young adult EFL students' (38) perceptions on the impact of mass media tools in the improvement of their speaking skills. The results of the questionnaire conducted for this purpose displayed the fact that subject EFL students believed in the positive effect of mass media tools on their speaking skills but they were not aware of. Keywords:  MMT (mass media tools), A-V M (audio-visual materials), ESL (English as a Second Language), EFL (English as a Foreign Language)


The survey of literature is presented from the last over ten years, pertinent to the ever present problem--sudden death. The paper presents mainly the problems of epidemiology, and the possibilities and methods of preventing sudden death, as well as the organizational activities increasing the chances of resuscitation of patients with sudden cardiac arrest.


Based on the analysis of environmental impacts of scallop cultivation,the estimation of N and P pollution loads in scallop cultivation is improved.The contributions of organic matter mineralization in sediment and excretion by scallop on inorganic nutrient are considered at the same time.The estimation of N and P pollution loads in scallop cultivation is calcu-lated in Jiaozhou bay under this plan.


Ultra precision CNC milling can be used to fabricate the Microchip electrophoresis on the substrate of PMMA which exhibited a better electro-osmosis performance. All micro-channels on the chip are 150μm X 140μm in section area, and the separation micro-channel is 5 cm long. The top chip and the bottom one are packaged with hot embossing technique with the ponder pressing machine at the condition of 80°C 0Pa, 5min. EOF performance is theoretical studied based on the theory of low Reynolds Number, electro-osmotic mobility could be calculated μ∞ =2.3 × 10-4 cm2/Vs. While the experiment test EOF with current monitoring method show that the apparent electro-osmosis mobility is μ∞ = 3.02 × 10-4 cm2/Vs at pH9.18, 5mmol/L borax buffer solution. The difference between the theory calculation and experiment results could be explained by the XPS test which indicate that the surface valent bonds intensity were strengthened after milling fabrication.


This paper discusses some of the best practices in instructional supervision with a sharp focus on the knowledge and skills that a 21st century instructional leader is in dire need of. This is done side by side with a qualitative study of instructional supervision in Adventist secondary schools in Ranen Conference, West Kenya Union Conference. This paper investigates further the perceptions of the administrators and teachers towards the clinical supervision, the challenges in the implementation of clinical supervision and the knowledge the administrators have on clinical supervision. An interview schedule was formulated and used to gather information from the five principals of the secondary schools in the conference. Evidence of the findings indicated that at least supervision is being conducted in these institutions even though the frequency, intention and the approach varies greatly from one institution to another. Moreover, the administrators interviewed expressed their strong beliefs in the place of clinical supervision as the new instructional order and as the only means to inspire teacher's professional growth and subsequently quality learning.


This study employs qualitative approach and some instruments to collect the data such as interview, Focus Group Discussion (FGD), literature study, and document analysis. The purposes of the study are to gather the information from the religious leaders about urgency in managing the adherent relationship, to know the management form, and to find out the aspects that are managed. The result of study concludes that religious leaders really agree to the regulation determined by government on urgency in managing the adherent relationship and involve the religious leaders as well community organization to build interfaith harmony.


The molecular identification using 26S ribosomal RNA indicated that the Candida species in this study was Candida catenulata strain QD16.1. Treatment of C. catenulata with different antifungals revealed that fluconazole (F) was the most inducer to the virulence factor lipase followed by itraconazole (I), then miconazole (M), while combination of (F) and (I) synergistically inhibited lipase induction, so it reduce Candida virulence. Purification of lipase extracted from C. catenulata growth medium was performed using ammonium sulfate [(NH4)2SO4] precipitation and Sephadex G100 gel chromatography which resulted in one peak of purified enzyme. The pure enzyme detected that the optimum pH was 5.5, temperature was 37°C. The value of Km was 0.271 mM and Vmax was 14.94 U/ml. The metal ions Na +, K+, Ba+ and Fe+2 inhibited lipase activities, while Hg+2 strongly reduced it. However, Zn+2 exerted an enhancement to lipase activity. EDTA and -mercaptoethanol inhibited lipase activity indicating that it is a metalloenzyme. The detergents Tween 80 and SDS enhanced its activity, while Tween 20 and Triton x-100 inhibited it.


In this paper a mathematical model is developed for the dynamical analysis of typical heavy vehicles chassis submitted to road irregularities. The mathematical model simulates the chassis of a front engine urban bus, using a finite element representation. The vehicle uses leaf-spring front and rear suspension system. The passengers and the vehicle engine are represented by discreet systems of mass-spring-damper. The suspension of the vehicle is modelled using four discreet systems, one for each tire, simulating a suspension made of leaf-springs. In the present investigation, a more realistic model for the road irregularities is incorporated to the analysis methodology. Such a model considers that the pavement irregularities are defined in a non-deterministic model. The pavement roughness is modelled by a weakly stationary, second order and ergodic random process. In this way, a direct relationship between the mean square values of the irregular profile and the roughness power spectrum density (PSD) can be obtained. The dynamic response of the system, when submitted to the crossing of irregular surfaces associated to different types of pavements is compared with limits of human comfort proposed by code recommendations.


Conventional target tracking systems are based on powerful sensor nodes, capable of detecting and locating a target in a large deployment area but most systems require high transmission power levels and a large volume of messages, much time for neighbor discovery operations, and many sensors to detect the target at a given time. We propose a two‐level cooperative and energy‐efficient tracking algorithm (CET) that reduces energy consumption by requiring only a minimum number of sensor nodes to participate in communication, transaction, and perform sensing for target tracking in wireless sensor networks. It is expected that only the nodes adjacent to the target are responsible for observing the target to save the energy consumption and extend the network lifetime as well by using a wakeup mechanism and a face‐aware routing. Through performance analysis and simulation studies, we demonstrate that CET improves target capturing speed and outperforms some existing protocols of target tracking with energy saving under certain ideal situations. Copyright © 2009 John Wiley & Sons, Ltd.


Using Chinese provincial data from 1997 to 2006, we examine the role of education in regional innovation activities. We test the spatial autocorrelation of provincial innovative activities and find significant support for it in the data, suggesting the need to incorporate spatial dependence in estimating the impact of education on innovation. We find that workers' tertiary education is significantly and positively related to provincial innovative activities measured by invention patent applications per capita. The result does not vary when spatial dependence is incorporated in the estimation. Thus, we find strong and robust evidence for the prediction of the endogenous growth theory about the positive effect of human capital on innovation.


Antidepressants by frequency of administration and use in medical practice among all psychotropic drugs take the second place after the tranquilizers, due to the high prevalence of depression and subdepression in the world. Despite the relatively extensive arsenal of antidepressants, they unfortunately do not meet modern requirements in terms of their effectiveness and especially safety in a medical application. The purpose of this article is a summary of modern ideas about toxicodynamics and kinetics of antidepressants of different chemical structure. The basis of toxicodynamics of tricyclic antidepressants (TCAs) are disorders of the peripheral and central nervous system (CNS) and the heart. Clinical picture of overdose with TCA and monoamine oxidase inhibitors (MAOs) can be grouped according to their influence on the autonomic nervous system (anticholinergic, adrenoblocking action), cardiovascular system and CNS. Thus, pharmacotherapy of depressive states and subdepressive states from groups of tricyclic antidepressants and MAO inhibitors are potential and real danger of the emergence and development of intoxication. Toxicodynamics of these groups of antidepressants is characterized by multivector nature of effects, which requires appropriate measures to prevent their implementation.


The invention relates to a wallpaper water-based ink and a method for making the same. The ink comprises the following components: 10-25 parts by mass of a thermochromic pigment, 20-45 parts by mass of a polyurethane resin, 10-15 parts by mass of a rosin resin, 5-9 parts by mass of monoethanolamine, 13-22 parts by mass of deionized water, 0.3-0.7 part by mass of a water-based antifoaming agent, 0.05-0.12 part by mass of a water-based dispersant, 0.1-0.3 part by mass of sodium benzoate, 0.2-0.5 part by mass of a mildew inhibitor, 0.6-2.3 parts by mass of an antiseptic, 1.2-2 part by mass of ultrafine wollastonite powder, and 2.5-5 part by mass of glycol. The wallpaper water-based ink provided by the invention has the advantages of slight odor, nonflammable property, variational colors with temperature variation, and mildew proof and bacterial inhibition effects; and no pollution occurs during the preparing process, and VOC emission is low.