Introduction: Treatment of multiple myeloma (MM) has improved over the last decade. Although long-term survival is noted in some patients, emergence of resistant disease still prevents cures. The objective of this study was to define "liquid biopsy" parameters that identify patients who do not benefit from a particular treatment before relapse becomes evident by serological markers. Having such parameters at hand will potentially inform changes in treatment.
 Methods: Here, we apply low-pass whole genome sequencing to profile a uniform cohort of 45 relapsed and refractory MM (RRMM) patients who have been treated in a multicenter phase II trial evaluating the combination of elotuzumab, pomalidomide, bortezomib and dexamethasone (elo-PVd; NCT02718833). Peripheral blood plasma samples were acquired for circulating tumor DNA (ctDNA) evaluation at four different timepoints (screening, cycle 3 day 1 (C3D1), cycle 5 day 1 and end of treatment). The concentration, relative fraction and copy number profile of myeloma-derived ctDNA were determined across all timepoints.
 Results: At the time of this preliminary analysis, 17 patients (35%) continue on treatment whereas 28 patients (58%) have developed progressive disease (PD). Our data suggest that ctDNA levels at screening and C3D1 strongly correlate with progression-free survival (PFS). Patients with available follow-up samples (n=40) were stratified according to ctDNA levels at C3D1 of treatment. Patients with a residual ctDNA level <10% showed a significantly longer PFS (median 17.6 months (95% CI: 1.4-6.5)) as compared to those with ctDNA levels ≥10% (median 5.9 months (95% CI: 0.2-0.7), log-rank Mantel-Cox test P=0.0006). The kinetics of ctDNA were largely concordant with the course of M protein and serum-free light chains (SFLC). To test our hypothesis that ctDNA assessment could be particularly useful for patients with inconclusive serological markers (minimal response (MR)/ stable disease (SD) by IMWG criteria), we performed a subgroup analysis of all patients with MR/SD at first follow-up (C3D1). In this group of 19 patients a residual ctDNA fraction ≥10% translated into a significantly shorter median PFS (1.6 months, 95% CI: 0.1-0.8) as compared to ctDNA levels <10% (5.8 months, 95% CI: 1.2-11.4, P=0.02).
 Conclusions: These data indicate that "liquid biopsy" evaluation of ctDNA may refine prognostication and provide added predictive value over serological markers alone. While in the large majority of cases ctDNA has excellent concordance with M protein and SFLC for monitoring of MM disease progression, ctDNA may identify patients where relapse is imminent before it can be detected by serological parameters. This approach may therefore complement our framework for treatment decisions. Notably, this approach is highly scalable, cost-efficient and provides information about the clonal evolution of MM without the need for a bone marrow biopsy.

 Yee: Adaptive: Consultancy; Amgen: Consultancy, Honoraria; Takeda: Consultancy; Celgene: Consultancy, Honoraria, Research Funding; Karyopharm: Consultancy; Bristol-Myers Squibb: Consultancy, Research Funding. Lipe:amgen: Research Funding; Celgene: Consultancy; amgen: Consultancy. O'Donnell:Sanofi: Consultancy; Amgen: Consultancy; Celgene: Consultancy; BMS: Consultancy; Takeda: Consultancy. Munshi:Abbvie: Consultancy; Amgen: Consultancy; Celgene: Consultancy; Abbvie: Consultancy; Amgen: Consultancy; Adaptive: Consultancy; Adaptive: Consultancy; Janssen: Consultancy; Celgene: Consultancy; Takeda: Consultancy; Janssen: Consultancy; Oncopep: Consultancy; Takeda: Consultancy; Oncopep: Consultancy. Richardson:Bristol-Myers Squibb: Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Oncopeptides: Membership on an entity's Board of Directors or advisory committees, Research Funding; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Amgen: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees. Anderson:OncoPep: Other: Scientific founder ; Sanofi-Aventis: Other: Advisory Board; Janssen: Other: Advisory Board; C4 Therapeutics: Other: Scientific founder ; Gilead Sciences: Other: Advisory Board. Raje:Celgene Corporation: Consultancy; Amgen Inc.: Consultancy; Merck: Consultancy; Takeda: Consultancy; Janssen: Consultancy; Bristol-Myers Squibb: Consultancy. Lohr:T2 Biosystems: Honoraria; Celgene: Research Funding.

 This abstract reports on the quadruple regimen elotuzumab, pomalidomide, bortezomib and dexamethasone which is not yet approved for the treatment of multiple myeloma in the United States.


An overlooked fact about tomorrow in English is that for some speakers, it allows non-utterance time readings as well as the utterance-time interpretations expected of a pure indexical. 1. Last week, UPS said that the package would be delivered tomorrow... (a) UT reading: I hope it arrives on time! (b) Non-UT reading: It still hasn't shown up! There are several possible explanations of non-UT readings of tomorrow. First, they may be due to Free Indirect Discourse, a literary style where temporal indexicals are interpreted relative to the main character's perspective. Second, tomorrow might be anaphoric rather than purely indexical, similar to now [1]. A third possibility is that tomorrow is a shifty indexical sensitive to speech verbshifted contexts [10]. Lastly, tomorrow might have a perspectival component capable of anchoring to salient event-time perspectives. I present results from a series of experiments showing that nonUT readings of tomorrow are acceptable in American English and exploring these four analyses. Experiment 1: How acceptable are non-utterance time readings? Experiment 1 tests whether American English speakers accept non-UT interpretations of tomorrow. Since the goal is to establish a theory-neutral baseline of acceptability, Exp. 1 uses sentences that were predicted to have non-UT readings on all four accounts. The sentences tested have third-person subjects, since first-person subjects block Free Indirect Discourse interpretations [4]; they also embed tomorrow under a speech verb, as required by shifty indexicals. The speech-verb embedding also sets up a salient event-time perspective as required by the perspectival account. We tested the availability of non-UT interpretations through a comic-captioning task on Mechanical Turk. Participants (n=72) were asked to rate the accuracy of the sentence as a caption for the third panel of a comic (Fig. 1) on a 7-point Likert scale. The ratings for tomorrow were compared with three other temporal expressions: the anaphoric the next day; the day-of-week name of the second panel (always true); and the day-of-the-week name of the first panel (always false). Figure 1: Exp. 1 example stimulus


Recent writing on diasporas has encouraged a shift away from viewing them as either quantifiable entities or as inevitable outcomes of international migration. Scholars now seek to highlight the ways in which diasporic identities are actively made and remade, and the connections forged both within and between places from such efforts. This paper addresses two dimensions of the process as they related to individuals of Irish birth and ancestry in Buffalo, New York, in the late nineteenth century. The first dimension relates to print culture and the role of the weekly Catholic Union newspaper in structuring and circulating a diaspora nationalism with a strong anticolonial identification, the second to the process of performing public acts of Irish nationalist memory that were simultaneously declarations of American loyalty. In the latter case, Robert Emmet (1778-1803), organizer of the 1803 rebellion in Dublin, became the pivotal figure around which a culture of commemoration took shape from the mid-1880s onwards. Together, these two dimensions of reading and remembrance offer examples of how diaspora-related cultural creativity was fashioned and articulated in one place and how it could be used to project a distinct Irish-American community while mobilizing opinions about Ireland's political future.


Introduction: One of the most spectacular discoveries of the Cassini mission is jets emitting from the southern pole of Saturn's moon Enceladus. The composition of the jets is water vapor and salty ice grains with traces of organic compounds. Jets are observed by multiple instruments on Cassini. Recent observations of the visible dust plume by the Cassini Imaging Science Subsystem (ISS) identified as many as 100 jet sources located along fissures across Enceladus' south pole called "Tiger stripes" [1]. There is a recent hypothesis that some of these jets are an "optical illusion" caused by geometrical overlap of continuous source eruption along the tiger stripes in the field of view of ISS [2]. UVIS observations: The Cassini Ultraviolet Imaging Spectrograph (UVIS) has observed occultations of several stars and the Sun by the water vapor plume of Enceladus. During the solar occultation separate collimated gas jets were detected inside the background plume [3,4]. These observations directly provide data about water vapor column densities along the line of sight (LoS) of the UVIS instrument. While Enceladus and its plume occult a star or the sun, UVIS takes spectroscopic measurements in its Far UltraViolet (FUV) and High Speed Photometer (HSP) channels. In the UVIS occultation mode the spatial dimension of the solar/stellar image is projected onto two windows on the detector, and focused onto 1024 pixels in the spectral dimension, each having a width of 0.606 Å [5]. During a solar occultation in 2010 95 successive spectra have detected attenuation of the solar light by the vapor, each integrated over intervals of 1 sec. We can calculate the optical depth of water vapor from the UVIS spectrum by summing over the wavelength range 850–1000 Å and normalizing the occulted signal by the non-occulted signal. Doing so for every spectra successively acquired during the occultation we can plot water vapor optical depth as a function of time during the observation. The optical depth can then be converted to the column density along the line of sight of UVIS. The result of this multi-step calculation for the 2010 solar occultation is shown in the top panel of Figure 1 (blue curve). Model: We have constructed a 3D direct simulation Monte Carlo (DSMC) model for Enceladus jets and currently apply it to the analysis of UVIS jet observations. The Monte Carlo model tracks test particles from their source at the surface into space. The initial three-dimensional velocity of each particle contains two components: a velocity Vz which is perpendicular to the surface, and a thermal velocity Vth which is isotropic in the upward hemisphere. The direction and speed of the thermal velocity of each particle is chosen randomly but the ensemble moves isotropically at a speed which satisfies a Boltzmann distribution for a temperature Tth. Vth is the parameter determining the jet widening rate per altitude and as


This paper attempts to uncover the semantic history of the concepts of "dialectic" and "didactic" which goes back to the Ancient Greece. I compare and contrast Socrates/ Plato's and Aristotle's approaches to dialectic. Dialectic became associated with formal logic in Scholasticism, and, as such, came under attack by secular and religious humanists in late Medieval Europe. The history of didactic began with Aristotle who introduced it in Sophistical Refutations to indicate a type of argument, synonymous to demonstration, but not antonymous to dialectic. Almost forgotten during the late Antiquity and early Middle Ages, didactic enjoyed wide acceptance by Ramists, especially Commenius, who saw in it a revolutionary methodological approach to education differing from the Scholastic trivium. While the contemporary use of didactic, whose intellectual value has significantly diminished since Commenius, is largely confined to the realm of instruction, dialectic became associated with the ideas of Hegel and Marx.


It was believed that adolescents delay more and more the emancipation from home and this became an updated topic for the social results that it has today. Our objective is to measure the relationship children- parents to know if, at the end of the century, adolescents consider it part of their process of growth or, as it was before, a necessity to be free from them. Hypothesis : do current adolescents cohabit in a climate that takes them to be less urged to achieve their independence from parents home? Method : free interviews and semi directed ones with standardized protocol. Results : during 1994-1999- two hundred and eighty Argentine (18-20 years, both sexes) said to be conformed with the relationship (84% with their mothers and 72% with their fathers), that the family climate was pleasant(85%) and that they were respected in their decisions (88% mother and 85% father). They thought in becoming independent (64%), not to get rid of their parents (85%) but because they will feel happy (71%),or to make their own experience (65%), to achieve independence (57%) or because they felt already mature (52%). Most of them (53%) neither cared get rid of their parents nor felt fear doing that (56%) and did not feel (85%) to be loosing their parents.  It was confirmed that there is a delay to live independently. Such a postponement is not only owed to the economic situation, mostly the harmonic family climate predisposes to continue living with parents that embody new paternal models. . Leaving home is associated more to the pleasure of managering the own life than to getting rid of oppresor parents.


Composite actuators and sensors manufactured by combining a ferroelectric ceramic such as lead zirconate titanate (PZT) and a passive phase such as a polymer are used in a variety of applications including SONAR, vibration damping, change of structural shape (morphing) and structural health monitoring. The composite route provides specific advantages, including tailored piezoelectric response, high strain, a degree of flexibility and increased damage tolerance compared to conventional dense monolithic ceramic materials. For piezoelectric fibre composites, where fine scale brittle ceramic fibres of 40-800µm in diameter are introduced into a ductile polymer matrix, the composite strength and failure mechanism ultimately depends on the mechanical properties of each phase and their volume fraction. This paper examines the mechanical properties of piezoelectric fibres and the matrix phase and discusses the influence of fibre volume fraction on mechanical properties and failure mechanism of the composite. The 'critical' and 'minimum' volume fraction of fibre based piezocomposite sensors and actuators are also determined. The data is of particular use in determining the failure stress, failure strain and failure mechanism of composite actuators and sensors subjected to high levels of stress, for example in applications where these materials are embedded into structural elements for shape control and morphing.


Background: Tuberculosis is a global disease leading to cause death worldwide. The Revised National Tuberculosis Control Programme (RNTCP), Directly Observed Treatment Short Course (DOTS), was launched to reduce tuberculosis mortality, improve patient adherence to treatment, and prevent the development of drug resistance. The aim of this study was treatment outcome of tuberculosis. Treatment outcome is an important indication of tuberculosis control programme.
Methodology: An ambispective observational study was conducted in a government general hospital from August 2019 to January 2020 on the treatment outcomes of PTB and EPTB in the 15 years and older age group, both males and females, on category I regimens. Patients with comorbidities like HIV, diabetes, and social habits like smoking were included. Record based TB diagnosed data (August 2019 to January 2020) are taken and asses their treatment outcome after 6months of complete therapy. The recorded and collected data were analysed to evaluate the success rate of treatment outcomes for PTB and EPTB.
Results: A total of 350 subjects were enrolled in the study, of which 311 are included and 39 are excluded due to incomplete data. The study with age group of 15 and above years where males 218(70.10%) and females 93(29.90%). Total pulmonary tuberculosis cases are 277 (89.07%), and extrapulmonary tuberculosis cases are 34 (10.93%). Subjects with HIV 48(15.43%), Diabetes 54(17.37%) and Tobacco smoking 85(27.33%). The treatment outcome was observed as follows: cured 144 (46.30%), treatment completed 98 (31.51%), transfer out 10 (3.21%), died 27 (8.69%), treatment failure 7 (2.26%), treatment lost to follow-up 14 (4.50%), and treatment regimen changed 11 (3.53%). At the end of the treatment, the success rate was found to be 78%.
Conclusion: This study shows that the TB patients' treatment success rate was 78%, which is slightly less than the RNTCP norms. The died rate was 8% which is higher than national average. Perhaps the services need to improve tuberculosis case detection in HIV patients, while cure rates have to be improved in RNTCP. EPTB case enrolment is very low, whereas the referral system has to improve its services. So that EPTB cases enrolment may increase its number. The early detection may enhance the cure rates in patients.


OBJECTIVE
The study was carried out to explore the coping behaviour of spouses of schizophrenic patients.

METHODS
28 in-depth interviews were analysed with a view to discover the spouses' ways of dealing with illness-related burden.

RESULTS
Most spouses reported problem-focussed coping strategies, such as information seeking and crisis planning. Release-focussed coping strategies, such as relaxation activities, time-out and temporal disengagement, are likely to be used when the situation is perceived as unchangeable and spouses feel that they have to look after themselves as well. In the long-term, cognitive-emotional strategies are of great importance, aimed at the re-appraisal of the spouses' mental illness and a greater sense of self-efficacy in dealing with acute and everyday burden.

CONCLUSION
Spouses' coping strategies not only have a strong influence on their perception of burden, but also on marital satisfaction and on their commitment to the affected spouse.


Run personality layer above the operating system kernel threads that make any personalization layer is responsible in the new state of the kernel unknown. This prevents the kernel to perform operations on the thread has been set in one of these new states, where these operations on the state of the thread itself (for example, cancel, suspend, change the priority) is very sensitive. Instead, the kernel will be redirected to these operations threads handler for the individual layers, which then processes the operation. So in essence, the kernel can be extended by using additional layer of personality, so it can be used to run real-time applications for other existing real-time operating system written.


This paper presents a robust method for constructing a panorama from images.Firstly,in order to mitigate the variation of the illumination conditions,the histograms of the overlapped areas are equalized.Secondly,extracting the seed points,the highly textured point in the overlapped area,by using phase correlation.Because ROI is restricted within overlapped areas,more accurate correspondences are obtained.Finally,the weighted Block Matching Algorithm(BMA) is used to minimize image distortion caused by camera rotation.Comparing the performance of the methods which is Peak Signal to Noise Ratio(PSNR) with multi-types images,results demonstrates the robustness of the method.


Taking the construction of Xiaoyi underground garage as the example, this paper introduces the calculation of air exhausting and smoke exhausting amount in underground garage and equipment room, and sums up some experiences in the design.


Indonesia is Malaysia's second tourist generating country after Singapore, therefore it is important to
look at the macroeconomic determinants of Indonesia tourism demand in Malaysia in order to maintain
and sustain the significant Indonesian tourist inflows into Malaysia. This study employed quarterly data
from 2000Q1 to 2014Q4 to estimate Indonesian tourism demand with the explanatory variables of real
income, travel cost and exchange rate. The empirical findings suggest that there is a long-run
equilibrium relationship between Indonesian tourism demand and the specified determinants. In
summary, higher Indonesian real income, higher travel cost and stronger Indonesian currency will
encourage more Indonesian visitors visiting Malaysia.


[RFC6294] makes a survey of Proposed Use Cases for the IPv6 Flow
Label. The IPv6 protocol includes a flow label in every packet header,
but this field is, according to [RFC6294], not used in practice. This
document describes how the alternate marking method can be used as the
passive performance measurement method in a IPv6 domain.


Industry 4.0 has received a massive amount of attention worldwide in the past few years as a technological infrastructure to provide efficient operations in existing production systems as well as fast-tracking the implementation of internet-connected technologies across various industries. Industry 4.0 technologies have been considered as a strategy and implemented successfully in various developed countries. However, in emerging economies (or developing countries), the implementation of Industry 4.0 is not as successful as developed nations because of various challenges. However, fast-moving economies can take advantage of Industry 4.0 techniques as their requirement to operate at faster rates, capitalizing on new technologies that can drive efficiencies. This chapter examines the sustainability issues of Industry 4.0 in developing or emerging economies countries. These sustainability issues are related to scientific, technological, and societal issues.


Objective To study the relationship of meteorological conditions to the epidemic activity of adenovirus.Methods Samples obtained from 8 197 children hospitalized with acute respiratory tract infections(ARIs)during 2006 to 2010,were tested for adenovirus with direct immunofluorescence assay.Meteorological factors including mean temperature,relative humidity,rainfall amount,duration of sunshine and mean wind velocity were collected monthly.The relationship between activity of adenovirus and metrorological conditions were analyzed by linear regression and Stepwise regression analysis.Results Adenovirus was identified in 1.28% of 8 197 specimens.The positive rates of ADV was varied in different years(χ2 = 9.46,P = 0.046).There was a distinct seasonality;the positive rate was higher in spring and summer,especially in summer with the rate up to 2.73%(χ2 = 45.47,P 0.001).ADV activity was positively correlated with mean temperature and duration of sunshine,but negatively correlated with wind velocity.There also existed interrelation between mean temperature and relative humidity for ADV activity,but only the mean temperature has a statistically significant impact on ADV activity.Conclusions ADV plays an important role in respiratory tract infection in children.The epidemic activity of adenovirus is related to meteorological factors.


The results of a blinded pilot study researching the correlation of thermographic abnormalities and spinal segmental dysfunction are presented. The highest agreement resulted between focal increases in thermal emission and fixation (64.7%). Other parameters studied were tenderness and textural skin changes which agreed with thermographic findings 63.7% and 59.9% respectively. Correlation coefficients were calculated for each subject and reasons for the wide range (r = .14 to .77) were discussed. Discussion of this research design and suggestions for future study were also presented.


The present paper is devoted to the improvement of the -order convergence of with memory derivative free methods presented by Lotfi et al. (2014) without doing any new evaluation. To achieve this aim one more self-accelerating parameter is inserted, which is calculated with the help of Newton's interpolatory polynomial. First theoretically it is proved that the -order of convergence of the proposed schemes is increased from 6 to 7 and 12 to 14, respectively, without adding any extra evaluation. Smooth as well as nonsmooth examples are discussed to confirm theoretical result and superiority of the proposed schemes.


We develop new algorithms based on multiband correlation models for the recognition of hyperspectral textures in three dimensions. The dependence of the observed texture of a material sample on viewing and illumination angles can have varying degrees of complexity. The bidirectional texture function (BTF) describes the appearance of a textured surface as a function of the illumination and viewing directions. The lack of appropriate hyperspectral image sets has limited attempts to characterize the BTF for 3D hyperspectral textures. In this paper, we use the DIRSIG model to generate a set of hyperspectral images over ranges of illumination and viewing angles in the 0.4 to 2.5 spectral region. We evaluate the performance of our methods for recognizing three-dimensional hyperspectral textures under unknown illumination angle.


On behalf of the Program Committee we are pleased to welcome you to the 2010 International Symposium on Computer Architecture held in Saint Malo, France.

It has been a great honor for us to serve as PC chairs of the prestigious ISCA conference. The ISCA conference is well known in the community as the forerunner in Computer Architecture because of its unique ability to provide, under one roof, maximum exposure for the newest ideas in the field. It is the responsibility of this conference to shape the direction Computer Architecture will take in the future and to promote its enormous potential.

Traditionally, the technical program of ISCA included some of the best research work in Computer Architecture, from the academia and industry. This year's ISCA program is as strong as ever, a testimonial to the continued vitality of Computer Architecture research. This year's program features papers on today's "hot" computer architecture topics, including energy efficiency designs, caches, memory subsystems, accelerator architecture, evaluation techniques, reliability and fault tolerance. This year we feature a unique QOB (Quantitative Out of the Box) session that emphasizes qualitative new innovative papers vs. thorough quantitative analysis papers. We hope you will enjoy and learn from the presentations and the papers.

The conference papers selection is the fruit of a long and rigorous process. The conference is grateful to all of the authors for the time and effort invested in submitting their best work. 245 papers were submitted to the conference, out of which the Program Committee selected 44 papers to be presented in the ISCA 2010 conference (18% acceptance rate).

We have been fortunate to recruit an outstanding Program Committee of 46 members that took the overwhelming task of selecting the best papers. Committee members contributed their time and expertise towards the goal of making this conference a success. We would like to deeply thank each and every Program Committee member. Only now we understand the enormous load they took on themselves: reviewing the submitted papers (we performed a total of 1200 reviews), interacting with other PC members and participating in the full day PC meeting marathon at the O'Hare Airport in Chicago (February 20th 2010).


Rubber mount is the research object in this paper.While thinking about the dynamic characteristics(demand) of high-speed automobile which is contradictious between low frequency range and high frequency range,we have a try to improve the dynamic characteristics by improving the structure of rubber mount.An analytical model for the rubber mount whose structure has been ameliorated is set up.The theoretical analysis and numerical simulation are put up.The(results) show that the dynamic characteristics of the rubber mount has been improved.It is helpful to carry improvement for the structure of rubber mounts in our country.


The problem of incomplete data is quite typical in sociological, economics or statistical studies that employ online data. The possible reasons for the incompleteness are: errors and changes at the data source websites, failures and errors in the instruments for collecting data, etc. Since missing data is generally undesirable in labor market forecasting, the preferred solution is filling-in the gaps through the use of an appropriate method that wouldn't bias the results. In our paper we present a brief review of methods for eliminating incompleteness of data and describe the application of the k-means method to fill the gaps in the labor market online data that we previously collected with a dedicated software system. We evaluate the effectiveness of the method by comparing the produced results (average wages and number of ads posted by the companies) with the data additionally collected by the system through the enhanced API-based mechanism. Further, we use autoregressive integrated moving average (ARIMA) model to provide forecasts for the labor market demand in IT specialists. Validation with the data subsequently collected for the last months of 2018 suggest reasonable accuracy of the model, which can be useful in labor market monitoring and management.


The point of view of this book is that the study of politics can be advanced by the quantitative analysis of political discourse. Why be quantitative? In reply, it is perhaps appropriate to bring out the limitations of qualitative analysis in terms of the work of the present writer. At the end of World War I, research on politically significant communication was almost entirely qualitative, consisting in the discovery and illustration of propaganda themes and their use. When the present writer described the propaganda of World War I in Propaganda Technique in the World War (1927)1 he took note of certain common themes running through the propaganda of all belligerent powers. The themes were:


The purpose of this study was to track changes in athletic identity and life satisfaction of elite athletes over time as a function of retirement status and the voluntariness of retirement decisions. Sixty-two elite Australian athletes from 3 different phases of their athletic careers were surveyed 5 years apart. Athletic identity was shown to decrease as athletes approached retirement. Athletes who retired voluntarily reported an increase in life satisfaction post-retirement. These findings support the need for athlete career education programs that emphasize autonomy and career planning.


Abstract— The data of Mechanik on the distribution of bone tissue mass have been analyzed statistically, summarized, and tabulated in a form convenient for reference. For comparison, analyses have been made of Mechanik's data on the distribution of bone marrow mass and of the data on the relation of skeletal mass or bone tissue mass to body weight as given by Mechanik in 1926 and by Borisov and Marei in 1974. About half of the bone tissue mass was in the limbs. The fraction in the arms and shoulder girdle was slightly greater in the males; that in the pelvic girdle was greater in the females. Standard deviations of the fractions of bone tissue in individual bones in each sex averaged about 10%, but ranged as high as 20%. Within this uncertainty, extrapolation to total body mineral may be made from measurements of a single bone. There were marked differences between the distributions of bone tissue and of marrow within the skeleton. Thus, the spine and pelvis contained 31% of the total marrow and 22% of the total bone tissue, while the skull and mandible contained only 7% of the total marrow but 15% of the total bone. While differences in other parts of the skeleton were smaller than these, it is clear that the weights of whole bones cannot properly be used in studies on bone mineral metabolism. The skeletal weight was rather constant at 13‐14% of the body weight in the males of the two populations over a wide age range. There was no sex difference in this parameter in the 4th and 5th decades of age, but the skeletons of older women tended to be lighter than those of contemporary men. Bone tissue average 8.4% of body weights in men and 6.9% in women, with considerable variation in the latter.


OBJECTIVE
To determine the physical violence profile against lesbians, gays, bisexuals, transvestites and transsexuals (LGBTT).

METHOD
Descriptive study, with a quantitative approach, carried out with sexual minorities of the municipalities of Juazeiro do Norte and Crato, Ceará, Brazil. A structured form was used to collect data. The study was previously approved by a Research Ethics Committee.

RESULTS
316 LGBTT members, mostly gays, single, mestizo and with a mean age of 24.3 years, took part in the study. Among the types of violence suffered throughout life, physical violence ranked second (31.3%); in this category, pushes (21.8%) and hits (17.4%) prevailed. The preferred place for attacks was the face (84.4%), and most of the aggressors are unknown persons (13.6%).

DISCUSSION
LGBTT victimization is a serious violation of human rights, with negative repercussions on health. The results point to a picture of social homophobia, similar to that observed across the Brazilian territory through reports published by the Secretariat for Human Rights of the Presidency of the Republic. Sexual minorities are victims of routine attacks that result in temporary and/or permanent sequels, such as torsions and fractures. The threat of attack is constant, since the major attackers are unknown bystanders.

CONCLUSION
The LGBTT community is victim of physical violence and its negative repercussions. The confrontation of this reality implies the elaboration of political and social strategies, from governmental and non-governmental sectors, in order to counteract and reduce this type of violence directed to this group.


The Coulomb formation in slightly elliptic reference orbits for two different two-craft formation geometries is studied. The fully constrained formation requires both spacecraft to be aligned along the nadir direction. The underconstrained formation only requires the spacecraft to maintain a constant separation distance allowing each spacecraft to rotate freely on the surface of a sphere. The Udwadia–Kalaba (U–K) equations of constrained motion are applied along with a constraint stabilization method to obtain the minimum integrated control effort required for formation maintenance in both scenarios, where a logic is introduced to determine the maximum Coulomb force. In addition, two nonlinear optimal control strategies are applied for formation achievement and maintenance. For each formation geometry, the fuel efficiency as measured by the integrated control effort of the thrusters obtained using the U–K formulation is compared to that obtained using nonlinear optimal control strategies.


Abstract The paper focuses on Customer Relationship Management (CRM), based on latest national and international studies of the subject. The goal of the paper is to identify how the selected companies that operate in Slovakia understand the concept of CRM and to what degree they actively use it. Thereafter authors compare different approaches to management of company's relationship with customers. They wanted to focus on a deeper analysis and decided to use in our orientation and evaluative research also a different approach, such as collaboration with international experts. In the paper the authors identify level of use of social CRM in selected companies in Slovakia and based on expert opinions of members of an international group they design an optimal model of CRM.


Hepatitis C remains the most common indication for orthotopic liver transplant (OLT) worldwide. In the era of all oral direct-acting antiviral (DAA) therapy, sustained response rates (SVRs) greater than 95% have been observed across multiple populations with compensated liver disease including the majority of previously designated ''special populations.'' This is especially important in patients with cirrhosis where SVR is associated with improvements in survival and reduction in risk for hepatocellular cancer and decompensation requiring OLT. Recent studies in those with hepatitis C–related decompensated cirrhosis have demonstrated that SVRs can indeed be achieved in the majority of these individuals, and short-term follow-up from these studies has shown that SVR is often accompanied by improvement in measures of decompensation including Model for End-Stage Liver Disease (MELD) score and Child-Turcotte-Pugh (CPT) score. Moreover, because hepatitis C recurrence after OLT is associated with worse outcomes, achieving SVR before transplant in a decompensated population with chronic hepatitis C will likely allow these patients to achieve long-term outcomes not different from non–HCV-infected populations. In the SOLAR-1 and SOLAR-2 studies, those with decompensated cirrhosis with genotypes 1 and 4 were randomized to receive sofosbuvir/ ledipasvir with low-dose ribavirin for 12 or 24 weeks. No difference was seen in SVRs in the 12or 24-week arms, and the therapy was well tolerated (Fig. 1). Similar results were reported in the ALLY-1 study where the combination of sofosbuvir/daclatasvir and low-dose ribavirin for 12 weeks in cirrhotic patients was described across all genotypes (Fig. 2). Moreover, these studies both reported improvement in MELD and CPT scores 4 weeks after therapy had been stopped with longer-term follow-up results expected. These studies have been complemented by realworld data from the United Kingdom where SVRs in Childs B/C patients were from 60% to 86% in genotype 1 and 43% to 71% in genotype 3 patients receiving 12 weeks of sofosbuvir with ledipasvir or daclatasvir 6 ribavirin. The reasons for the lower SVRs in patients with decompensated cirrhosis compared with compensated liver disease are not well defined. The presence of clinically significant portal hypertension may reduce hepatic exposure of DAAs by significant portosystemic shunting, although one report demonstrated that intrahepatic sofosbuvir and ribavirin metabolite levels are sufficient in cirrhotic livers from those who underwent OLT. The presence of cirrhosis may alter the metabolism of DAAs in the liver as well, although for protease inhibitors, higher area under the curve values have been observed in those with decompensated cirrhosis and to date, no protease inhibitors have been approved in the therapy of those with hepatitis C and decompensated liver disease (http://www.rxabbvie.com/pdf/viekirapak_pi.pdf, https://www.olysio.com/shared/product/olysio/prescribinginformation.pdf). For paritaprevir/ombitasvir/dasabuvir, a recent update to the label was made contraindicating the use of this set of DAAs in the treatment of those with decompensated liver disease, as opposed to not recommending their use in decompensated liver disease, which was in the original label, based on recent safety reports. Finally, higher doses of ribavirin than the 600 mg may be beneficial, although the anemia is more difficult to manage in those with decompensated liver disease. Another possibility is that the fibrotic matrix may create viral reservoirs that are difficult for DAAs to penetrate, with


it. The risks of harm are still significant and the societal benefits, though predicted, are not yet well established. But it does suggest that individuals should consider networksharing of their genetic information not just for personal benefit or for "fun" but also because doing so can benefit others. It also suggests that as the risks of harm diminish and the benefits to others increase, we all may have a moral duty to take ourselves out of the genetic closet.2


We introduced the fading memory effect to the model portraying the prediction in physical condition. The classical model is known as the Banister model. We presented the existence and uniqueness conditions of the exact solutions of this model using three different memory including the bad memory induces by the power law and the good memories induced by exponential decay law and the Mittag-Leffler law. We derived the exact solutions using the Laplace transform for the non-delay version.


Chapter 1 Preface Chapter 2 Acknowledgments Chapter 3 Introduction Chapter 4 Locke, Smith and the Foundations of Democratic Capitalism Chapter 5 Rousseau and Egalitarian Nationalism Chapter 6 The Political Conservatives: Burke and Hume Chapter 7 Utilitarian Reformers: Bentham and Mill Chapter 8 The Rise of Socialism-Revolutionary Marxists and Evolutionary Social Critics Chapter 9 Fascism, National Socialism Chapter 10 Max Weber and the Rise of the Modern Bureaucratic State Chapter 11 Functionalism or the Lack Thereof in Modern Society: Durkheim Chapter 12 Modernity and Conflict Theorists Chapter 13 Microsocial Perspectives-Viewing Daily Life Chapter 14 Cross-cultural Theories for the 21st Century: Feminism, Fundamentalism, and Environmentalism Chapter 15 Conclusion Chapter 16 People and Terms to Know Chapter 17 References Chapter 18 Index


Recent trends in data-centric systems have motivated significant standardization efforts, such as the Data Distribution Service (DDS) to enable data dissemination with guaranteed Quality of Service (QoS). However, clear design guidelines and techniques for the support of reliable and scalable DDS-based deployments, especially for (mobile) data intensive services, such as Internet-wide information dissemination for breaking news or financial analysis services, are still missing. After an analysis of main DDS fault-tolerance and scalability deployment issues, this paper proposes a novel solution with two core original contributions: i) DDS-compliant routing substrate to facilitate reliable data dissemination between mobile devices; ii) relay-based DDS support infrastructure with limited overhead to enable scalable Internet-wide data dissemination. Our solution, especially tailored for mobile computing scenarios, is lightweight and requires neither persistency nor heavy operations at mobile device side. Reported experimental results confirm that our proposal can guarantee desired scalability requirements with a limited network, CPU, and memory resource overhead.


SUMMARY A cold-adapted influenza A virus, CR-37 (H1N1), derived from genetic reassortment between A/Ann Arbor/6/60 (H2N2) cold-adapted variant virus and A/California/10/78 (H1N1) wild-type virus, was tested in Japanese adult volunteers. The CR-37 live virus preparation induced only low-grade clinical reactionsin volunteers for the first 3–4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38–0 °C). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccinees was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against thevaccine strain of ≤ 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NA1) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic H1N1 variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.


Most Lower Cretaceous rocks in Sonora are part of the Bisbee Group of southern Arizona, deposited within a basin considered to be an extension of the Gulf of Mexico into Texas, New Mexico, Arizona and Sonora. However, the Lower Cretaceous rocks of the Sierra Los Chinos are more closely related to the Lampazos rocks of eastern Sonora, and consequently, to Chihuahua stratigraphy. In the Los Chinos area, the exposed Lower Cretaceous units include the Agua Salada, Lampazos and Los Picachos Formations. The Upper Cretaceous sequence is made up of volcanosedimentary rocks overlain by Tertiary intrusive, volcanic, and sedimentary rocks. Lower Cretaceous rocks of the Sierra Los Chinos area are strongly folded and faulted, with kilometer-scale overturned folds and thrusts. The area was affected by at least two episodes of normal faulting. The Sierra Los Chinos sequence is paleogeographically and tectonically related to the Chihuahua tectonic belt and is unrelated to the Bisbee Group of Sonora. The marine conglomerate at the base of the Los Picachos Formation represents a significant active tectonic episode at the end of the Albian, possibly related to re-activation of strike-slip faulting due to tectonic transpression. The compressional structures in the Los Chinos area are similar to structures of the same age in the states of Chihuahua, Coahuila, and Nuevo Leon.


This study investigates the relationship between CEO characteristics and accruals quality from public firms listed in Indonesia Stock Exchange between 2010 and 2017. This study used two accruals quality measures namely absolute abnormal accruals and performance matched abnormal accruals. Specifically, absolute abnormal accruals are proxied by two proxies, a) the modified Jones model (Dechow et al. 1995) and b) accrual estimation error the augmented specification of Dechow and Dichev model (2002) as suggested by McNichols (2002). Furthermore, performance matched abnormal accruals are proxies by two proxies, a) performance matched abnormal accruals by using Kothari et al. 2005) and b) current accrual. This study identifies CEO characteristics as CEO female, financial work experience, business skill, tenure, and CEO founding.  The empirical findings that several CEO characteristics (i.e., CEO female, financial work experience, business skill, tenure, and CEO founding) is significantly associated with accrual quality; these in turn, may affect the quality of the firm's reporting. Overall, these results are consistent with the prediction of the upper echelons theory and have implication in corporate financial reporting.


The United States is continuing to experience a significant growth rate in the use of low- and moderate-temperature geothermal resources for direct use applications, which is making an increasing contribution to the United States energy demands. This paper provides an overview of how and where geothermal energy is being used, the extent of that use, and what the development trends and concerns appear to be. The applications discussed include industrial processes, heat pumps (heating and cooling), pools and spas, aquaculture and agriculture applications, and space and district heating projects. 3 tabs.


Abstract : Data on the decayed, missing, and filled surfaces and teeth of aeromedical evaluation referrals were compared to that of the USAF aviator population. Although the aviator population had a significantly larger number of decayed surfaces and teeth (p less than .01 to p less than .001), this difference could be explained by the population survey looking at the worst case scenario. When looking at the total decayed, missing, and filled surfaces and teeth (DMFS and DMFT), there was essentially no significant difference between the oral health status of the aeromedical evaluation referrals and the USAF aviator population. Keywords: Oral health status, Dental needs survey.


Two adult patients who underwent living donor liver transplantation and had an acute accumulation of right-sided pleural effusion were studied. The chest x-ray (CXR) of patient 1 revealed no specific finding 3 days before surgery. Patient 2 was known to have a pleural effusion and underwent pigtail drainage before transplant. After anesthesia was induced and venous catheters were inserted, a portable chest radiograph was taken to confirm the positions of the central venous catheters and the endotracheal tube. A massive right-sided pleural effusion was observed unexpectedly in both patients. Approximately 2000 mL of transudative fluid was surgically drained through the right diaphragm in patient 1 when the abdominal cavity was opened. The acute accumulation of massive pleural fluid in patient 2 was the result of clamping of the pigtail drainage tube while the patient was being transferred to the operating room. When the tube was unclamped, 2000 mL of fluid was drained. The intraoperative and postoperative transplant courses of both patients unfolded without incident, and both were discharged from the hospital in stable condition. These cases suggest that CXR after induction of anesthesia and before liver transplantation surgery is recommended, not only to document the positions of the central venous catheters and endotracheal tube but also to detect a potentially life-threatening pleural effusion that requires appropriate management.


. The paper deals with the problem of a quasistatic frictional contact between a nonlinear elastic body and a deformable foundation. The contact is modelled by a normal compliance condition in such a way that the penetration is restricted with a unilateral constraint and associated to the nonlocal friction law with adhesion. The evolution of the bonding field is described by a first-order differential equation. We establish a variational formulation of the mechanical problem and prove an existence and uniqueness result under a smallness assumption on the friction coefficient by using arguments of time-dependent variational inequalities, differential equations and the Banach fixed-point theorem. 49J40, 35J87.


A numerical simulation study accounting for trap and defect effects on the current-voltage characteristics of a 4H-SiC-based power metal-oxide-semiconductor field effect transistor (MOSFET) is performed in a wide range of temperatures and bias conditions. In particular, the most penalizing native defects in the starting substrate (i.e., EH6/7 and Z1/2) as well as the fixed oxide trap concentration and the density of states (DoS) at the 4H-SiC/SiO2 interface are carefully taken into account. The temperature-dependent physics of the interface traps are considered in detail. Scattering phenomena related to the joint contribution of defects and traps shift the MOSFET threshold voltage, reduce the channel mobility, and penalize the device current capabilities. However, while the MOSFET on-state resistance (RON) tends to increase with scattering centers, the sensitivity of the drain current to the temperature decreases especially when the device is operating at a high gate voltage (VGS). Assuming the temperature ranges from 300 K to 573 K, RON is about 2.5 MΩ·µm2 for VGS > 16 V with a percentage variation ΔRON lower than 20%. The device is rated to perform a blocking voltage of 650 V.


Previous international studies, in which the authors participated, have revealed that involvement of teachers in decision-making and responsibility-taking processes is crucial for their receptiveness towards implementation of current and future educational change. It is also evident that the role and responsibilities of school principals have changed significantly over the last decade or two. An indication was obtained of the views of South African secondary school principals regarding the involvement of their teachers in processes of school change and these were compared to the views of school principals from other countries. The results for the South African sample, as well as those for the other nine countries, showed that there was fairly strong support for the involvement of teachers in most school-change activities. It also appeared that, in comparison to other countries, principals in the South African sample occupied a middle position in all of four clusters of possible activities, as well as for the mean questionnaire score. South African Journal of Education Vol. 26(2) 2006: 189-198


This study explores students" participation in the development of scoring rubric for EFL debate assessment. The study investigates 1) What categories and semi-areas do students include in their own rubric? 2) How do students view the semi-area included in students" own rubric? and 3) How are students aware of EFL debate assessment and rubric development? A total of 50 university students majoring in English education participated in mini-debate sessions as a pair activity and the rubric development. As a result, the students proposed 22 semi-areas and each area was allotted into one of the four categories: linguistic aspects, non-linguistic aspects, content, and organization. Even though all groups included linguistic aspects in their rubric, they highly valued organization. Next, students had a positive attitude on their engagement in EFL debate assessment and rubric development.


The influences of anhydrous hydrogen fluoride on the native form of hen egg-white lysozyme under standard conditions of peptide synthesis were investigated by measuring the enzymatic activities of materials recovered from mixtures of anhydrous hydrogen fluoride and hen egg-white lysozyme. The enzymatic activity of hen egg-white lysozyme gradually decreased on incubation with anhydrous hydrogen fluoride at a given temperature. After incubation of the mixture at 0 °C for 60 min, at least three fractions could be separated by gel-filtration on Sephadex G-50. One of these was eluted in the same position as native lysozyme and was fully active enzymatically. Its ultra-violet, and circular dichroism absorptions were identical with those of native lysozyme, and the tetragonal crystals obtained from this fraction could not be distinguished from those of native lysozyme.


The experiment was made by the piglets fed on jifeng biological bacteriam and the capbility of productive was tested at the same time.The result indiated that :In the experiment ,the daily gain of piglets fed Jifeng biological bacterium was higher than that of control group by 8.9%.And the price of feed of piglets fed Jifeng biological bacterium was higher than that of control group by 14.0%.The economic benefit of each piglet fed Jifeng biological bacterium was higher than that of control group by $128.On the other hand,the survival rate of piglets fed Jifeng biologcal bacterum was higher than that of control group by 20.7%.


In order to promote the energy saving and emission reduction in the taxi industry, and improve the management mode of the new business such as the ride-hailing service. This paper studied the system architecture and performance index of taxi multi-function integrated terminal. The research applied the Beidou satellite positioning precision measurement technology in the vehicle terminal for remote monitoring and testing. It also developed an energy consumption acquisition module based on OBD(on-board diagnostic system) to read the vehicle status, which including the speed, travlled distance, oil consumption and the engine parameters. This paper studies the high performance integrated Beidou positioning module which supports Beidou and GPS, which can obtain the information such as the vehicle position, driving speed, driving direction, driving angle and so on. It set up the metering - billing module based on the taxi automatic sampling test and Taxi fares adjustment, provided real-time monitoring of taxi metering - billing and fares adjustment data automatic update for measurement and supervision department, and embed the safety control module. Therefore, the taxi service level, the energy conservation and emission reduction can be improved.


A paediatric online diagnostic tool called Isabel was launched at the Royal College of Physicians in London this week.

The tool has been developed by a charity, also known as Isabel, which was launched by Charlotte and Jason Maude, whose daughter Isabel almost died at age 3 years of necrotising fasciitis as a complication of chicken pox, after it was missed by a series of doctors. The diagnostic tool was set up with help from paediatric intensive care consultant Joseph Britto at St Mary's Hospital in London, who helped …


Nowadays, many organizations consider organizational agility crucial for survival and ongoing competition, because it empowers any organization to develop a series of distinct capabilities so as to rapidly and constantly respond to changes and take advantage of new opportunities. This study mainly intends to examine the effect of certain agility capabilities on organizational agility. The statistical population comprises a total of 455 employees working at staff offices of the National Iranian South Oil Company (NISOC), among which 206 individuals were selected as sample based on the Morgan's Table through simple random sampling. For data collection, two standard questionnaires were employed. In order to analyze the data, SPSS and LISREL were employed. The results of structural equations modeling suggested that the agility capabilities (i.e. competency, flexibility, responsiveness, promptitude and technology) leave a significantly positive effect on organizational agility. Finally in this regard, several recommendations were made concerning the results.


A 71-year-old man was admitted for intractable gastrointestinal bleeding because of residual gastric cancer with liver metastasis (▶Fig.1). He presented having had three episodes of hematemesis or melena in the previous 30 days. Conventional endoscopic management for bleeding of unresectable gastric cancer is challenging because of the low clinical success rate and high amount of rebleeding [1]. After careful discussion with the patient and his family, treatment using endoscopic ultrasound (EUS)-guided lauromacrogol injection was decided. Repeat endoscopy revealed persistent active bleeding from the anastomosis of the residual stomach (▶Fig. 2). A vessel originating from the submucosa and extending into the mucosa was identified using EUS-aided color Doppler imaging (▶Video 1). EUS-guided lauromacrogol injection was performed using a 22-gauge needle (Echo 3–22; Cook Endoscopy, Winston-Salem, NC, USA). Moreover, color Doppler imaging confirmed the absence of blood flow after therapy (▶Video 1). Endoscopy immediately after the injection confirmed the absence of bleeding (▶Fig. 3). The patient was followed for more than 6 months without further episodes of gastrointestinal bleeding. No adverse events or complications were recorded during or after the procedures. The efficacy of EUS-guided therapy of nonvariceal upper gastrointestinal bleeding has been described. Series have been published with success rates of 88%– 100% for the treatment of Dieulafoy's lesions, pancreatic/gastroduodenal artery pseudoaneurysms, gastrointestinal stromal tumors, periampullary tumors, duodenal ulcers, and intractable marginal ulcers after Roux-en-Y gastric bypass [2–4]. To our knowledge, EUS-guided lauromacrogol injection for the treatment of refractory gastric cancer bleeding has not been reported in this setting. E-Videos


This paper describes a novel machine learning approach based on deeper and wider deep learning model, for better feature learning and latent feature discovery for the clinical name entity recognition task. The performance evaluation of the proposed framework with a benchmark clinical NLP dataset, the clinical CLEF eHealth challenge 2016 dataset, has led to promising performance, when assessed in terms of F-measure, Recall and Precision. The Hybrid CNN model with hyperparameter optimization led to an F-score 89 % for the CLEF eHealth 2016 Challenge task involving synthetic nursing handover dataset.


In 1991, the Minneapolis Community Development Agency (MCDA) launched the Neighborhood Revitalization Program (NRP) to national acclaim.1 Structured by formal neighborhood organizations, each of which has a history and its own internal politics, the program institutionalizes participation and enables citizens to determine how local community development funds will be spent. It has four goals: build neighborhood capacity, redesign public services, increase government agency collaboration, and create a sense of community. NRP envisions an active citizenry taking control of the democratic process by making crucial decisions about city spending. The NRP—heralded as one of the most progressive programs in the country to advocate civic engagement through viable neighborhood associations—may, however, both encourage and discourage certain groups from participating. Of late, the program has been criticized for promoting the interests of homeowners over those of renters, who tend to be minorities. The fact that political structures shape the outcomes of this policy highlights the limitations of the NRP and structure-based participatory empowerment. Thus, the controversy surrounding the NRP illustrates the pros and cons of remedying lack of civic participation by empowering citizens at the sublocal level of neighborhoods. Discussed in this article is the effectiveness of the NRP in particular and the logic of formalized participatory governance generally.2 Much of the rhetoric concerning the current "legitimacy crisis" in liberal democracy centers on the lack of citizen participation. Advocates claim that participation in governance is a primary way by which people gain more power in the political and economic system (Barber 1984; Boyte 1990; Bellah et al. 1991; Boyte and Kari 1996). The alleged connection between participation and power is epit[Political participation] enriches the lives of men not only by what it does for them but what it does to them. —Arnold Kaufman (1968)


Directional information adding method on the reference picture according to the present invention, reference to a reference picture indicated by the picture index to provide information about the picture or in either direction (forward direction or backward direction) from the block to, the coding , there is a feature that the unique information in the display order of the reference picture can tell whether the-th point on the inclusion in the reference picture indication information. Here, according to the present invention, the specific information that provides information on display order of the reference picture it may have the feature that the value denoted by (Picture Order Count) POC. In addition, the prediction motion vector calculation method according to the invention, using the motion vectors of the neighboring blocks performing the median operation, and in the wanted a prediction motion vector (PMV) of the block to be coded neighboring block for motion vector in the case of having obtaining the direction (forward direction or backward direction) information of the respective motion reference picture vector that is a reference, and with reference to the directional information of the acquired motion vectors, select the motion vector of the neighboring block, and in that to obtain the prediction motion vector of the block to be coded including the selected motion vector by performing a median operation it has that characteristic.


Cancer is an inevitable matter of concern in the medicinal chemistry era. Chalcone is the well exploited scaffold in the anticancer domain. The molecular mechanism of chalcone at cellular level was explored in past decades. This mini review provides the most recent updates on anticancer potential of chalcones.


Specific heat, magnetic torque, and magnetization studies of LiCoPO4 olivine are presented. They show that a unique set of physical properties of LiCoPO4 leads to the appearance of features characteristic of two-dimensional Ising systems near the Ne´el temperature TN = 21.6 K and to the appearance of an uncommon effect of the influence of a magnetic field on the magnetocrystalline anisotropy. The latter effect manifests itself as a first-order transition, discovered at ∼9 K, induced by a magnetic field of 8 T. The physical nature of this transition was explained, and a model describing experimental dependences satisfactorily was proposed.


In the first of a new series of articles on essential first aid in the GP practice, Wendy Berridge tackles fainting


8 Protein associations assume a significant part in the revelation of protein capacities and pathways 9 in natural cycles. Computational strategies have pulled in gigantic consideration among scientists 10 due to the capacity to foresee protein-protein cooperations and approve the got exploratory 11 outcomes. In this survey, we have audited a few computational techniques for protein-protein 12 communication expectation just as depicting significant data sets, which store both anticipated and 13 identified protein-protein associations, and the devices utilized for examining protein cooperation 14 organizations and improving protein-protein connection unwavering quality. 15 16


Objectives Prescription opioid diversion is a significant contributor to the opioid misuse epidemic. We examined the quantity of opioids consumed by emergency department (ED) discharged patients after treatment for an acute pain condition (musculoskeletal, fracture, renal colic, abdominal pain and other), and the percentage of unused opioids available for potential misuse. Design Prospective cohort study. Setting Tertiary care trauma centre academic hospital. Participants A convenience sample of patients ≥18 years who visited the ED for an acute pain condition (≤2 weeks) and were discharged with an opioid prescription. Patients completed a 14-day paper diary of daily pain medication use. To reduce lost to follow-up, participants also responded to standardised phone interview questions about their previous 14-day pain medication use. Outcomes Quantity of morphine 5 mg tablets (or equivalent) prescribed, consumed and unused during a 14-day follow-up. Quantity of opioids to adequately supply 80% of patients for 2 weeks and 95% of patients for the first 3 days was also calculated. Results Results for 627 patients were analysed (mean age ±SD: 51±16 years, 48% women). Patients consumed a median of seven tablets of morphine 5 mg (32% of the total prescribed opioids). The quantity of opioids to adequately supply 80% of patients for 2 weeks was 20 tablets of morphine 5 mg for musculoskeletal pain, 30 for fracture, 15 for renal colic or abdominal pain and 20 for other pain conditions. The quantity to adequately supply 95% of patients for the first 3 days was 15 tablets of morphine 5 mg. Conclusions Patients discharged from the ED with an acute pain condition consumed a median of fewer than 10 tablets of morphine 5 mg (or equivalent). ED physicians should consider prescribing a smaller quantity of opioids and asking the pharmacist to dispense them in portions to minimise unused opioids. Trial registration number NCT02799004; Results.


This paper describes a reference architecture developed in the European project EURIDICE, funded by the European Commission for new approaches regarding supply chain design and information systems integration of different stakeholders throughout supply chains. The detailed high level architecture design phase has been finished and it will be described in this paper with the most important architecture components providing novelty for supply chain design.


The reaction of racemic α-keto β-lactams 5a–5c with the commercially available chiral compound trans-4-hydroxy-L-proline (6) in the presence of a catalytic amount of Bi(NO3)3⋅5 H2O in EtOH gave a diastereoisomer mixture of β-lactams with a pyrrole ring at C(3) (7 to 12). This is the first enantioselective synthesis of optically active β-lactams (=azetidin-2-ones) that possess a pyrrolyl residue at C(3), in a single step.


This work analyzes and evaluates the possible use of different speech coding algorithms, namely Melp 2.4 kbps (NATO Stanag 4591), Celp 4.8 kbps (FS1016) and Celp 8.0 kbps (ITU-T G.729), in portable laser optical wireless communication at low bit rates, following a brief description of the laboratory scale system designed and constructed for the experiments. Related to the various outdoor application examples, the results based on the Perceptual Evaluation of Speech Quality (PESQ) algorithm for the quality assessment are presented. Results, obtained from the laboratory prototype, proved that MELP vocoder is the choice of speech coding because of its several advantages such as increased transmission distances under similar conditions and achieved power economy at reduced link distances especially in portable applications.


Three genes from a shotgun genomic library of Flavobacterium columnare virulent strain ALG-00-530 were identified, characterized, and selected for differential expression analysis based on sequence similarity to putative virulence genes from related species. These genes were: glycosyltransferase (gtf), nitric oxide reductase (norB) and thioredoxin (trx). A collection of 30 F. columnare strains, including strains from genomovars I and II, were tested for the presence of these genes. Distribution patterns of gtf, norB, and trx across the species were not uniform. Nucleotide sequence variation was observed between genomovars for each gene; however, strains within the same genomovar shared identical gene sequences. Nine strains of F. columnare, from both genomovars, were chosen for gene expression analysis. The expression profile of these genes varied when selected strains were grown in vitro under identical conditions. ALG-00-530, a high virulent strain, was chosen for gene expression comparison under standard growing conditions, iron-limited conditions and in the presence of skin explants from channel catfish. NorB, and trx gene expression levels varied when ALG- 00-530 was incubated under different conditions.


The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.


Sinulog is a dance ritual in honor of the miraculous image of the Santo Nino. The dance moves to the sound of the drums and this resembles the current...


for an Invited Paper for the HAW05 Meeting of The American Physical Society Nuclear Reactions with light ion and photon beams: Contributions to Neutrino Astrophysics MAMORU FUJIWARA, Research Center for Nuclear Physics, Osaka University In the star burning, the reaction processes such as charge exchange, inelastic scattering and fusion take place on the basis of the star hierarchy structure with various densities and temperatures. Experimental information from the nuclear reactions has been applied to the astrophysical phenomena observed by telescopes and to understand the isotope composition of meteorites in the solar and galaxy systems. For examples, charge-exchange reaction cross-sections relate closely toβ-decay and electron capture processes. From the observations of isoscalar giant monopole resonances in nuclei provided via inelastic scattering, one can argue the nuclear incompressibility, which is one of the important parameters for the supernova explosions and neutron star structure. Studies of photo-nuclear reactions are deeply related to astrophysics to understand the origin of element synthesis in the galaxy since the nuclear synthesis is made in the environment with ultra high intensity photons in supernovae. In my talk, I would like to show the recent results from the (3He,t) and (t,3He) and (α,α′) experiments with light ion beams in relation to the neutrino astrophysics. I also show the future possibilities of photoreactions at new facilities in Japan.


Urban residential areas are the homes of urban citizens,and the main places where people live and have a rest;its environmental quality directly influences the physical and mental health of the urban citizens.However,because of the high density of population of urban residential areas and comparative lack of green fields,greening construction of urban residing areas is restricted.But there are many buildings in the urban residential areas,and the area of wall space is great,and the wall space can be made full of use to develop vertical greening for the purpose of enlarging vegetation quantity,adjusting the greening view,making up for the lack of the greening land.Therefore,it is necessary to change the traditional greening mode,and greatly develop wall vertical greening of the urban residential areas,which can be beneficial for the construction of a pleasant,clean and comfortable environment.Thus the quality of the living environment can be greatly improved.


This paper uses modeling to analyze the impact of alternative economic policy instruments on carbon dioxide and other greenhouse gas emissions from the United Kingdom (UK) transport sector. The forecasting models incorporate cross-elasticities between modes. The paper considers the impact on emissions of carbon dioxide and other greenhouse gases of economic policies such as an increase in fuel taxation and reductions in public transport fares.


Based on analyzing all kinds of risk in the economic responsibility auditing in universities currently,according to reveal the connotation of modern risk-oriented audit,the article points that applying risk-oriented audit methods can effectively evade the audit risk and improve the auditing quality.


In this paper, a signal processing method for high-speed underwater acoustic transmission of image is presented. It has two parts. Part 1 is underwater acoustic coherent communication signal processing. Part 1 includes 3 technical points. 1. Doppler shift compensation. Chirp signals are inserted between data packages. A correlation process between two copy correlation results gives more accurate estimation of the mean Doppler shift. Resample the data to compensate it. In feedback adaptive equalizer an adaptive phase compensator with fast self-optimized least mean square (FOLMS) adaptation algorithm is utilized resulting in better motion tolerance than compensators with 2nd order PLL algorithm. The performance of the combination of mean Doppler shift compensation and adaptive phase compensator is quite good. 2. A combiner is used in advance of equalizer. Both combiner and feedback adaptive equalizer are based on FOLMS adaptation algorithm and have reduced computation complexity and good performance. 3. Cascaded equalizer and Turbo-TCM decoder and the iteration algorithm. A new bit-symbol converter based on Soft Output Viterbi Algorithm (SOVA) is studied. Comparing with the traditional decision, coding and mapping algorithm, new converter can reduce BER by nearly 2 orders. Part 2 is a robust image compression algorithm. In high-speed underwater acoustic image transmission, there are always some error bits. Ordinary image compression algorithms, for example, JPEG and JPEG2000, are sensitive to error bits. One error bit may destroy whole image. So they are not suitable for high-speed underwater acoustic image transmission. Based on digital wavelet transform and fixed length coding, a robust compression algorithm for optical and acoustic image is studied. The algorithm includes 4 technical points. 1. Utilizes CDF9/7 wavelet base to transform the images. 2. Analysis the energy distribution of the subbands coefficients. A suitable transformation layer number is 3. 3. Apply different quantization steps to different subbands in accordance with their energy distribution. 4. Fixed length coding to prevent error propagation. The results show the algorithm achieves a balance among image quality, compression rate, and most important, robustness to bit error. The data rate of compressed true color optical image and gray scale acoustic image are 0.80 bit/pixel and 0.85 bit/pixel respectively. Image quality remains good when BER is lower than 10-3. There are some small dirty points when BER rise to 10-2. Based on the signal processing techniques described above, an underwater acoustic communication system is built. Its band is (7.5~12.5) kHz. Its receiving array is an equal spaced 8 elements linear array. Each element is semi-spherical directivity. QPSK and 8PSK modulation and iteration algorithm for cascaded equalizer and Turbo-TCM decoder based on Soft Output Viterbi Algorithm are used. The system is tested in Qiandao Lake, a 20-50 meters deep reservoir with lots of submerged hills. Low BER is achieved in 5.5 km rang when data rate is 10 kbps. One 256times256 true color image or gray scale image can be transmitted in 7 second. The product of its communication distance and data rate is 55 km*kbps. Without the limitation of the lake area, the product is estimated to reach 80~100 km*kbps.


Shaw's careful analysis of how refugee relief was intertwined with imperial history. As she notes, any troublesome refugees could be easily dispatched to imperial locales. When these opportunities for imperial transmigration diminished, so, too, did British sympathy for refugee aid. At the same time, the empire generated refugee crises of its own. If refugees had typically served as symbols of despotism overseas, then what happened in the case of those who were fleeing British violence? Today, Britain is confronting a global refugee crisis on an unprecedented scale. Shaw's nuanced history is a vital reminder of the twists and turns that intervention in refugee care has taken in the past and the varied effects such intervention has had. Much has changed since the days depicted in Shaw's meticulous account, not least the legal frameworks through which refugees and migrants interact, and Shaw is rightly cautious about drawing any easy parallels between past and present. Still, all historians of refuge and refugees have much to learn from this smartly told origin story.


The measurement of the Sound Strength (G) room acoustic parameter requires a calibration of the measuring system, so either the sound power of the source or the sound pressure level at a distance of 10 m in free field is known. Two procedures are described in ISO 3382-1: Calibration in a reverberation chamber and calibration in free field in a large anechoic chamber. Both methods require that all conditions in the measuring chain (amplification gains, sound card, cables etc.) remain fixed during calibration and in-situ measurements. This can be impractical mainly because measurements may be performed much later than calibration and at a distant location, and it cannot be guaranteed that the conditions in the measuring chain remain unchanged. In this paper a Two-step calibration procedure is proposed that removes the requirement of fixed conditions of the measuring chain. The procedure adds a second step to the normal reverberation room or free field calibration methods, in order to allow compensation for any shift in octave bands from the calibration to the in-situ measurement condition. The procedure is implemented in the ODEON Room Acoustics Software v.13.03 as a Two-step calibration to be applied in connection with the sine-sweep method for room acoustic measurements.


Dr. Woods is Professor and Chair, Department of Parent and Child Nursing, University of Washington, Seattle, WA. This research project was supported by a grant from the Division of Nursing, USPHS No. NUO1054. This paper formed the basis of her presentation at the National Conference on Women's Health, held in Bethesda, MD, June 17-18, 1986. Contributing to this paper were Martha Lentz, PhD, RN; Ellen Sullivan Mitchell, ARNP, PhD; Katherine Lee, PhD, RN; Diana Taylor, PhD candidate, RN; and Nitsa Allen-Barash, PhD candidate; all of the University of Washington School of Nursing.


Traditional approaches to modeling the effects of storm systems have relied on custom data bases and computer code. In addition, the effects of wind, waves, and storm surge are rarely modeled simultaneously using the same data structures or algorithms. For the coastal engineering and emergency planning community, this results in having to use different and complex sources of information. In addition, output products are often in formats difficult to use with planning support systems such as Geographic Information Systems (GIS) and Computer Aided Drafting. This paper describes a method of modeling the effects of large scale storm systems using an approach based on GIS technology, called 'TAOS'. A generic data base structure was developed, using available 'off the shelf' data sources such as satellite imagelY and public domain data where possible. Surface characteristics are determined from the results of satellite imagery. Meteorological input parameters may be in three modes: from historical storms, from hypothetical storms, or directly from the National Weather Service's (NWS) National Meteorological Center and National Hurricane Center model outputsfor forecasting. The TAOS storm model relies on solving flow equations for air and water via coupled finite difference solutions. The code is heavily optimized to run on either Intel 486, Pentium, or SPARC based computers, with the option to parallel up to three machines. Model runs result in output data bases in GIS format for the parameters of interest, such as maximum wind at surface, maximum still water height, maximum wave height, etc. As the outputs are in a standard GIS format, non-technical users may quickly access model output products. The results of TAOS are compared with existing storm models. Results of the TAOS runs on historical storm systems generally equal or outperform existing modeling techniques. Finally, the application of the TAOS system in the Caribbean Disaster Mitigation Project for a regional storm hazard assessment is outlined.


Presently, micro pollutants which occur in water resources worldwide are the main problematic issues causing hazardous effect on environment and harming human life. Polymeric resins are the effective adsorbents, which have properties like static chemical properties, high porosity and specific adsorbent sites. The new resin Guargum Mandelic Acid Resin (GMA), has been synthesized which is toxic free substance for the treatment of industrial waste water. Guargum Mandelic Acid Resin (GMA) has been used for the adsorption of heavy metal ions like Lead (Pb2+), Copper (Cu2+), Iron (Fe2+), Chromium (Cr²+), Zinc (Zn+²) etc. by batch and column method. The GMA resin was characterized by FTIR and SEM. In laboratory, experiments were performed at different pH range, concentration and time of contact.


We were pleased to read of the integration of SIGN into Healthcare Improvement Scotland so as to take advantage of their health economic expertise. The new team may wish to reflect on the review in the same journal issue of the use of direct oral anticoagulants (DOACs), formally known as NOACs, as an alternative to warfarin. Though well researched in terms of the details on use of DOACs, there were a number of oversights. Dabigatran, like warfarin, is susceptible to interpersonal variation, something the makers failed to make public, leading to legal actions. The reported noninferiority of rivaroxaban rests on a study where the INR in the warfarin arm was measured using a device which was subsequently recalled by the FDA due to unreliability. Prescribing DOACs costs the NHS around 25 times per patient more than warfarin and have not been shown to be substantially superior at stroke risk reduction. Indeed, well administered warfarin is superior. The enthusiasm for the new agents led to an increase of £100 million in NHS England expenditure in the year to November 2015. Even after allowing for the cost of routine INR surveillance, the cost of managing patients with DOACs is four times higher for no clear clinical gain. Furthermore, the new antidotes developed for DOACs' reversal cost between £2,500 and £5,000 per use, which is substantially more expensive compared to vitamin K injections to reverse a warfarin overdose.


PURPOSE: A batch and endless rolling system and a rolling method are provided to selectively implement a batch rolling process and an endless rolling process and to replace rolls without stopping a continuous casting process. CONSTITUTION: A batch and endless rolling system comprises a continuous casting facility (101), a cutter (110), a rolling mill (160), and a cooling device (170). The continuous casting facility produces main pieces having the thickness of 30-150 mm at 4.5-15mpm. A batch rolling process and an endless rolling process are selectively processed according to the casting speed of the main pieces produced in the continuous casting facility.


A high-level power dissipation model for filter- and transform-type digital signal processing (DSP) algorithms implemented using linearly connected multiply-add-based processing elements is presented. Exploration of alternative algorithms, architectures, and design styles for a given signal processing task in terms of high-level parameters is possible using this model. It is shown that there is often an optimal selection of the number and type of time-shared processing elements for VLSI implementation that minimizes the overall power dissipation. A major application of the proposed model is to make quantitative evaluations for exploration of alternative DSP algorithms and architectures. When combined with previously developed area-time metrics, the proposed power dissipation model permits a more realistic evaluation of new and existing circuit solutions to DSP tasks. >


The disagreement between writers such as Goody and writers who have taken a similar line to myself is not over whether literacy can be involved in great social changes, whether it can facilitate communication and the storage of information or whether it has become, in many places, a mechanism for operating social distinction. We are all agreed about this. In fact, all the points the author makes about the Iban, as he generously acknowledges in several places in the paper, are points I have made myself in relation to the Merina in a number of articles reproduced in How we think they think (Bloch 1998; originally Bloch 1968, 1989, 1994).


The invention discloses a human face tracking optimization method for a camera and an application. According to the method, interference of colors, similar to a human face, of objects on the periphery of the human face to a self-adaptive window can be reduced in histogram calculation optimization and jumping verification manners and the like on the basis of Camshift tracking, so that the camera can quickly and accurately track the human face; besides, when the method is applied to an intelligent health monitoring system, the human face can be quickly and accurately tracked, and preparations are made for acquisition of physiological parameters and expression recognition.


This article profiles the Mackenzie River Twin Bridges project, the largest field-cast ultra-high performance (UHPC) project in North America in terms of bridge size and total volume of UHPC joint fill material used. Part of the TransCanada Highway realignment near Thunder Bay, Ontario, Canada, The Mackenzie River bridges consist of twin two-lane bridges with three spans each (total length 590ft (180m)). The bridges use variable depth, continuous steel plate girders with full-depth precast, lightly prestressed concrete deck panels. This article presents a detailed examination of the project, which also includes precast concrete approach slabs and concrete deck panels connected at transverse joints and attached to steel girders using field-cast ultra-high-performance concrete.


The OECD on February 11 issued its final paper on the transfer pricing aspects of financial transactions (the OECD FT Paper), which will become Chapter X of the OECD Guidelines. This represents one of the last missing pieces of the OECD BEPS project. On July 3, 2018, the OECD had published a first discussion draft (Discussion Draft). The complexity of the topics and disparate regional approaches led to the publication of a non-consensus document, within which there were many areas where the OECD was seeking input from commentators.


The size distribution of cytoplasmic messenger RNAs (m-RNA) has been studied in rat liver and in monodifferentiated cells (mouse reticulocytes and myelomas). It has been found that the RNA which exhibits a « rapid turnover » and a polydisperse profile of radioactivity is refractory to phenol extraction. This property has been exploited to selectively isolate m–RNA from the phenol residue by means of an extraction at an alkaline pH. The sucrose density gradient profiles of m–RNA isolated from monodifferentiated cells show monodisperse peaks having the sedimentation coefficients expected on the basis of the molecular weights of monocistronic messages for α and β chains of hemoglobin (reticulocytes) and L and H chains of immunoglobulin (myelomas). The sedimentation profile of cytoplasmic m–RNA associated with rat liver polysomes shows a much broader distribution, with sedimentation coefficients ranging from 8 S to 28 S.


Learning organization is an organization that constantly extends its capacities for its future creativity. This phenomenon has been introduced during last 20 years and its aim is to enable organizations' managers and employees to resist to turbulent commercial environments and organizational competitive superiority and dynamism. in these organizations, delegation of authority, group and team work, and cooperative management, innovation and creativity, and other clear characteristics are emphasized, which have been discussed in this article in details. Another important concept dealing with learning organization is organizational learning. Organizational learning is a process of performances' improvement through more knowledge and understanding. Learning organization is the product of organization learning.


A consumable supply member for the image forming apparatus, which is an ink or refillable ink storing an amount of an amount of original. A housing which is oriented to the user the direction of gravity towards the bottom of the interior of the ink supply member is reduced. The image forming apparatus having a rotary latch, the top of the latch member cooperating with the supply and the supply member in place. In the first side is provided with a container inserted into the apparatus housing groove and a fluid outlet vent. Having a separation space between the fluid outlet and the vent port, such that when the user actuates a latch biasing member urging the housing to be expelled from the auxiliary supply member. The separation distance between the fluid outlet and vent maximized to facilitate the expulsion is, while the fluid outlet proximate the bottom of the ink retention minimal. A further embodiment describes a configuration of the supply member, the distance and the member users, specification, to name a few.


The study analyzed the essential conditions of contracts in the field of public procurement, which are somewhat specific and much larger in number compared to the essential conditions of ordinary business contracts. During the research, the authors established that the mandatory procurement conditions play a decisive role in the conclusion of public procurement contracts. The subsequent conclusion or non-conclusion of the relevant contract or its subsequent invalidation by the court will depend on how accurately the customer sets out the procurement conditions in his procurement announcement and in his tender documentation. Typical mistakes of customers when setting out the essential terms of procurement contracts and procurement conditions were considered. The results of the research can be used to improve the procurement process and the appropriate conclusion of contracts by customers and participants in public procurement in order to avoid typical mistakes or violations that may cause negative consequences in the future: cancellation of procurements, non-conclusion of relevant contracts, recognition of their invalidity or nullity.
Today, there is a huge public market in Ukraine, which functions thanks to the Prozorro electronic system. Legal relations on this market must comply with the Law of Ukraine "On Public Procurement" and other normative legal acts. Therefore, it is relevant to study the contractual process of public procurement with an emphasis on the essential conditions of the relevant contracts, which are derived from the mandatory procurement conditions. When considering the essential terms of public procurement contracts, contracts that are publicly available in the Prozorro electronic system were analyzed. Considering the practice of the Supreme Court, the typical errors of the customers in setting out the essential conditions and the corresponding negative consequences of these errors were considered, in particular, in the case of incorrect definition of the subject of the contract by the customers and excessive detailing of the procurement conditions by the customers in the procurement announcement and in the tender documents.
Analyzing scientific research and publications, it can be argued that the proposed topic is insufficiently researched and developed by other scholars in the field of civil and economic law. The subject of the contract, as a defining essential condition of the contract, was studied by scientists M. M. Aharkov, M. I. Brahinskyi, V. V. Vitrianskyi, E. O. Sukhanov, M. M. Hudyma and others. But none of these scientists paid attention to the fact that the subject of the purchase contract is a broader concept compared to the subject of the contract in other business contracts. Other essential conditions of the purchase contract were not investigated by the specified scientists.
The purpose of this article is the analysis of scientific publications, regulatory legal acts, their enforcement, judicial practice and features of the process of concluding contracts with the aim of establishing the determining factors of the formation of essential terms of contracts in the field of public procurement. Based on the results of the analysis, it can be stated that there are no such concept as essential procurement conditions in the current legislation.


Some recent studies have found that there are some side-channel vulnerabilities in the operating system. Attackers would exploit the side-channel vulnerability for malicious purpose, such as hijack connections, denial of service attacks, etc. Currently, most attacks are detected manually. In this paper, we found that the reason for the existence of network protocol side-channel vulnerability is the use of shared resources. Since the state of shared resource affects all connections, when a connection uses a shared resource, information about that connection can be inferred by observing the usage of the shared resource. In order to find the shared resources, we implemented a tool called TASR which is a method of static analysis. The first is to find out what shared resources are available by the definition of shared resources in static analysis. Then, the data packet is used as the taint source to search the tainted shared resources. The second step is to analyze the taint-transmission-path according to the acquired tainted shared variable. Then it can find the side-channel vulnerability. By using this method on TCP, UDP and ICMP protocols, we find the following four shared variables: challenge_count, tcp_memory_allocated, tcp_memory_pressure, sysctl_icmp_msg_per_sec. It is difficult for tcp_memory allocated and tcp_memory pressure to exploit, because they will go through multiple strict checks. Using challenge_count can hijack the connection and inject malicious packets. Using sysctl_icmp_msg_per_sec can assist in DNS cache poisoning attack.


Aiming that traditional sensor can't realize the posture sensing of mouse pointer,by comparing the differences between the two-axis acceleration sensor and two-axis gyroscope,the mouse pointer localization method using two-axis gyroscope was put forward.The measurement method for static-state revolving angle of two-axis gyroscope,the change rate calculation of the dynamic revolving angle and the optimization on the sensitivity coefficient of the mouse pointer as well as the ΔX and ΔY calculation of the mouse pointer were expounded in detail.Considering that the voltage drop and the change of environmental temperature would cause the zero drift of two-axis gyroscope,a new algorithm for dynamic self-tuning was presented and satisfactory results were achieved.The technology has been integrated into the production of wireless air mouse.


Abstract A simple experiment concerning the effect of temperature indicates that the larvae of Balanus balanoides always swarm in the 1st naupliar stage, and that the larvae are never retained in the mantle cavity until the cypris stage.


A numerical study of femtosecond soliton switching by the relative phase change of a weak control pulse is carried out for a Kerr coupler with the simultaneous presence of intermodal dispersion, cross-phase modulation, third-order dispersion, self-steepening, and intrapulse Raman scattering. It is shown (numerically) that cross-phase modulation, though it appears as a very tiny parameter, plays a positive role in this mode of soliton switching and that these perturbative effects may lead to useful soliton switching if the relative phase of the control pulse is monitored judiciously.


An antibiotic ointment failed to clear the lesion on the patient's back. A more detailed history revealed the nodule's troubling genesis.