The invention provides an identification method of superfine powder of a traditional Chinese medicinal material. The identification method is characterized by comprising the following steps: preparing a suspension from traditional Chinese medicine powder to be tested and a glycerinum test solution or mineral oil, shaking, immediately sucking the suspension, placing the suspension on a glass slide, covering the glass slide with a cover glass, slightly pressing to enable granules to be distributed evenly, and testing under a microscope, wherein when the detection result is that the number of granules with the width more than 180 microns is less than 1 and no granules with the width more than 210 microns are detected, the powder is the superfine powder. Through inspection on solvent carriers, concentration and use amount of the suspension and the limit of detection, the identification method can be used for more accurately detecting whether the powder conforms to the definition of superfine powder in pharmacopeia standards; in addition, the method is also applicable to various textures of traditional Chinese medicinal materials, and has a wider application range.


We previously reported that inoculation of rats with live vaccinia virus (VV) recombinants VVpyMT, VVpyLT expressing either the middle‐T (MT) or large‐T (LT) proteins of polyomavirus (PyV) can elicit immunity to challenge with syngeneic PyV‐tumor cells. We now report the results of cross‐vaccination studies. VVpyMT was ineffective against cells expressing LT protein but prevented development of MT‐expressing cells. Conversely, the VVpyLT was ineffective against MT‐expressing cells. In the two experiments performed, tumor growth enhancement rather than retardation was observed in VVpyLT‐vaccinated animals receiving PyV‐LT (FRLTI) challenge tumor cells. To determine the location of the major TSTA within MT, a further VV recombinant (VVpyMT/Cfr) was constructed that expresses only the unique C‐terminal segment of MT. VVpyMT‐Cfr and VVpyMT were equally effective in eliciting tumor immunity, indicating the presence of a major TSTA epitope within the unique C‐terminal region of MT.


Himantura bleekeri and Amphotistius imbricatus are bottom carnivores, with crustaceans ranking first in the food items followed by teleosts, molluscs and polychaetes. Number of poorly fed individuals was high in both the species. These species breed throughout the year. The male : female ratio of H. bleekeri for 1989-'05 and of A. imbricatus for 1997-'05 were 1:0.98 and 1:1.36 respectively. The length-weight relationship was: Log W= -8.7298 +2.7297 Log L for H. bleekeri and Log W = - 6.4691 +2.3119 Log L for A. imbricatus. Note


Using archaeological materials recovered from a housesite in Mobile, Alabama, Laurie Wilkie explores how one extended African-American family engaged with competing and conflicting mothering ideologies in the post-Emancipation South.


PUTUT EKO BAYUSENO. Water Resource Management in Oil Palm Plantation of PTPN III Rambutan Estate: Assessment on Grey Water Footprint Needs. Supervised by EDI SANTOSA. Internship was conducted at PTPN III Rambutan Estate, North Sumatera from 6 th February until 5 th June 2017, in order to enhance agronomic knowledge on oil palm production especially in the water resource management with special reference to grey water footprint analyze. The internship activity involved the technical aspects as worker (KHL) and manager (co-foreman and co-assistant). Observation included the water utilization by oil palm company of surface water, and the grey water footprint. The grey water footprint was calculated from the activity of fertilizing, weed controlling, pests controlling; and the water for assimilating the pollutants was considered from existing standing tree on the field including TBM and TM. The total grey water footprint was 7.732,16 m 3 ton -1 TBS consisted of fertilizing 7.139,22 m 3 ton -1 , weed controlling of 81,13 m 3 ton -1 , and pests controlling 511,81 m 3 ton -1 .


The massive multiple-input multiple-output systems (M-MIMO) and orthogonal frequency-division multiplexing (OFDM) are considered to be some of the most promising key techniques in the emerging 5G and advanced wireless communication systems nowadays. Not only are the benefits of applying M-MIMO and OFDM for broadband communication well known, but using them for the application of the Internet of Things (IoT) requires a large amount of wireless transmission, which is a developing topic. However, its high complexity becomes a problem when there are numerous antennas. In this paper, we provide an effective two-stage multiuser detector (MUD) with the assistance of the accelerated over-relaxation (AOR) iterative algorithm and Chebyshev acceleration for the uplink of M-MIMO OFDM systems to achieve a better balance between bit error rate (BER) performance and computational complexity. The first stage of the receiver consists of an accelerated over-relaxation (AOR)-based estimator and is intended to yield a rough initial estimate of the relaxation factor ω, the acceleration parameter γ, and transmitted symbols. In the second stage, the Chebyshev acceleration method is used for detection, and a more precise signal is produced through efficient iterative estimation. Additionally, we call this proposed scheme Chebyshev-accelerated over-relaxation (CAOR) detection. Conducted simulations show that the developed receiver, with a modest computational load, can provide superior performance compared with previous works, especially in the MU M-MIMO uplink environments.


Emerging studies revealed that tumor derived 2'3'-cGAMP could act as an immune transmitter and directly trigger anti-tumor immunity. Damage associated molecular patterns, e.g. damaged genomic DNA, released from injured cancer cells can be converted into 2', 3'-cGAMP by cGAS. Subsequently, cGAMP triggers STING pathway activation to produce type I interferons (IFNs) and other related innate immunity in the tumor microenvironment. Ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1), a membrane-bound nucleotide hydrolase, has been discovered as the predominant enzyme hydrolyzing 2'3'-cGAMP (Li, et al). Hence, ENPP1 blockade in the tumor milieu is a potential strategy against tumors by improving innate immunity response. In this report, we present a potent ENPP1 inhibitor ZX-8177. ZX-8177 showed an IC50 of 9.5 nM in a biochemical assay and an IC50 of 11 nM in MDA-MB-231 cell-based enzymatic assay. In a functional assay for evaluating efficacy of ZX-8177, the production of IFN-β1 by THP-1 cells was measured after the cells were cultured in the conditioned medium collected from MDA-MB-231 cells treated with or without ZX-8177. The interferon production assay showed an EC50 of 15 pM, suggesting that ZX-8177 effectively facilitated IFN-β1 production via cGAMP-STING axis. In CT-26 syngeneic mouse model, ZX-8177 treatment at 2 mg/kg, BID for 14 days can achieve around 37-60% tumor growth inhibition (TGI). No body weight loss was observed during treatment. Flow cytometry analysis indicated that ZX-8177 treatment resulted in a 2-3-fold increase in tumor-infiltrating NK (CD314+CD335+) cells, cytotoxic CD8 T cells (GranzB+CD8+), and M1-macrophages (CD206-MHCII+); and a decrease in M2-macrophages (CD206+MHCII-) (p< 0.05). Combination of Mitomycin C (0.5 mg/kg, i.p., BIW) and ZX-8177 (2 mg/kg, i.p., BID) in CT-26 model yielded synergistic anti-tumor efficacy (increased >30% TGI). The level of cGAMP in tumor tissue harvested from the combination treatment group was around 2-fold higher than that in the vehicle group. Furthermore, synergistic tumor inhibition of ZX-8177 and anti-PD-L1 antibody was also observed in MC38 mouse model. TGI of anti-PD-L1 antibody vs. combo treatment is 53% vs. 75%, p < 0.05. ZX-8177 has a favorable DMPK and safety pharmacology profile to support it as a clinical candidate for further development.
 Citation Format: Ying-ying Li, Zhiyuan Peng, Shuaijun Sun, Kun Guo, Deming Kong, Xiaomin Li, Yuning Xie, Siyu Shui, Yin Wang, Jinfu Yang, Xiaolin Alan Hao, Xiaoli (Shelley) Qin. ENPP1 inhibitor ZX-8177 enhances anti-tumor activity of conventional therapies by modulating tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5486.


There is inner closeness between students and campus, because some students do activities on campus. Public space are the most widely used by students in activities. So, the availability of public space on campus is very necessary. The quantity and quality of public space on campus is a main indicator in shaping student behavior. The purpose of a public space is to support student activities from the academy aspect and soft skill activities. While the availability of public space in the Faculty of Architecture and Design has not been able to provide a maximum container for students both in terms of quality and quantity. In this study try to identify the patterns of public space by using the sociopetal and sociofugal parameters. The concept of sociofugal and sociopetal is an important indicator in testing the quality of public space. Ideally a good public space is dominated by sociofugal aspects because it prioritizes socializing and discussing activities. This study uses architectural methods of behavour mapping which later facilitate the process of observation in the field. Hopefully later with the knowledge gained can contribute ideas for the design of the quality of public space in the future.


Objectives:To study the effect of electro-acupuncture(EA) at a classical inducing-labor acupuncture formula [Hegu(LI4)-Sanyinjiao(SP6)] on uterine smooth muscle coordinated contraction in late-stage pregnancy rat,so as to partly explore its scientific mechanism of inducing labor.Methods:Twenty-two healthy in early-stage pregnancy Wistar rats were randomly divided into a model control group and an EA group.And eleven healthy adult female Wistar unpregnancy rats were included in a normal control group.In the morning of the 20th day of pregnancy,the EA group was applied EA at bilateral Hegu(LI4) for 20min plus Sanyinjiao(SP6) 5min,a total of 25min was required.The intensity of EA was 0.2-0.3mA with 2/50Hz sparse-dense wave.Rats in control groups were tied 25min with bags at the same time.Outcome measures including Estradiol(E2),Progesterone(P) in serum and Prostaglandin F2α(PGF2α) in tissue were detected by Enzyme Linked Immunosorbent Assay(ELISA).And expression of Connexin 43(Cx-43) was measured by protein immunoblotting(Western Blotting).Results:Compared with the normal control group,the contents of E2,P and E2/P in serum,PGF2α and Cx-43 expression in the uterus in the model control group and the EA group were significantly increased(P0.05,P0.01).Compared with model control group,the contents of E2 in serum,PGF2α and the Cx-43 expression in the uterus in the EA group were significantly increased(P0.05),the EA group showed decreased serum P and increased serum E2/P,but with insignificant differences.Conclusion:Classical inducing-labor acupuncture formula combined with optimized EA stimulation parameters could active the uterus of late-stage pregnant rats by regulating the serum and uterus hormone levels,promote uterine coordinated contraction by increasing the expression of gap junction protein in smooth muscle of uterus.It might be one of its main mechanisms of inducing labor in the light of the molecular mechanism,and could provide scientific evidence for the application of acupuncture in obstetrics.


Aomoto has recently given an extension of Selberg's integral. We extend his proof to the q-case and establish a conjecture of Askey. Our result is equivalent to a constant term identity for the root system $A_n $. This extends a conjecture of Morris.


It has been highly recognized that heavy metals and other trace species pollution concerns the environment, as well as human health. This paper describes the rapid detection of mercury and iodine using laser breakdown time-of-flight mass spectrometry at high sensitivity without partial fragmentation interference from other species. Two irradiation wavelengths 1064 and 532 nm were employed under various experimental conditions. The second harmonic 532 nm performs excellent measurement results. The influence of pressure on signal intensity displays a linear growth when increasing the pressure. The power dependence shows that as the laser power increased, mercury ion and iodine ion signal intensity increased first and then decreased. Experiment with different buffer gases clarified the recombination of mercury ion and iodine ion with electrons when increasing the laser power, resulting in the decrease of mercury ion and iodine ion signal intensity. Mercury ion signal intensity can be enhanced 3.8 times and the signal intensity of iodine ion can be enhanced 1.3 times employing 35 ps 532 nm breakdown. The detection limits (3σ/ms) of mercury ion and iodine ion signal using 35 ps laser breakdown were 0.82 ppb and 6.18 ppb, respectively.


In recent years, the overall situation of the mainland's Haruki Murakami study is: The translations are more fully; Monograph on a small number of categories of research; The fruitful results mainly focused on the results of research on professional papers. Include the following aspects: Insight from the works of Haruki Murakami's art world; Insight from a comparative perspective of research writer Haruki Murakami and other works of literature; Art with modern trend of thought to explain the text of Murakami Haruki; Research that is the phenomenon of Murakami Haruki, "Murakami hot" papers. However, as the influence of Haruki Murakami large, our research team, the scope of the study are not enough. How to expand the areas of research literature Haruki Murakami achieve a comprehensive grasp of the future research efforts should be a major topic.


Since the report of P. Levine et al. (1941) showing that erthyroblastosis could be caused by incompatibility between maternal and fetal Rh blood groups, a number of studies have been published considering the role of natural selection in the maintenance of blood group diversity. This consideration was extended to include the relationship between blood groups and disease in humans (J. H. Aird, 1954; J. A. Buckwalter et al., 1956) and between blood groups and traits of economic significance in animals (F. J. Shultz and W. E. Briles, 1953; J. Kendel, 1959). The blood group systems in chickens (W. E. Briles et al., 1950; D. G. Gilmour, 1959~) have been used to aid in the study of performance differences between related individuals. Of the chicken systems the B locus has proved particularly valuable in this respect because polymorphism is usually maintained even after prolonged inbreeding (W. E. Briles et al., 1957; D. G. Gilmour, 1959b), and Briles and his co-workers (1949, 1993, 1954, 1955, and 1956) as well as Gilmour (1954) have reported that the heterozygotes in the B system demonstrate a selective advantage in regard to several performance traits. There can be little doubt that the blood antigens or the genes responsible for these antigens do affect certain performance traits that are seemingly not directly associated with the red blood cells. It is the purpose of this report to present evidence concerning the relationship between the R locus genotype of the female parents and the performance of their progeny. The effect on the progeny of various genotypic combinations in the female parents has never been studied in poultry because methods for dividing related parents into genotypic classes were not available prior to blood grouping. The performance of 2273 female inbred-hybrids, of the leghorn X heavy breed source produced over a 2-year period and tested in replicate a t 9 locations was studied, The chickens studied were produced from two sources of single cross dams, one a New Hampshire (H3) X Rhode Island Red (H6) female and the other the same H3 X a different Rhode Island Red (H13), mated with Single Comb White Leghorn males. A description of the parent lines, inbreeding levels, U locus alleles and serological cross-reactivity of these alleles is given in a paper by W. E. Briles et al. (1957). The leghorn sires were of the B locus genotype E2B13 and as identical genetically as possible. Because these leghorn sires were uniform throughout the test they did not contribute to the measured variation, and are not considered beyond the realization that each chick produced for study was half leghorn, and had either the B2 or the BI3 gene. This is shown in TABLE 1, Section B Idocus Blood Type , column Progenies. The H6 and H13 lines came from the same foundation breeder but they were purchased in separate years. The H6 line had two B locus alleles and the H13


This chapter borrows from middle-ground studies and related hybridity theory to argue that the Syro-Anatolian Culture Complex (SACC) was on an equal cultural footing with its much more politically powerful neighbor, the Neo-Assyrian Empire. Although Assyria would come to conquer most of SACC by about 700 BCE, for several centuries the two entities influenced one another culturally, an influence that is visible in their cultural products like wall reliefs and monumental statuary. In several cases, these reliefs and statues deliberately fused elements from both places to produce newly significant products, often in ways that emphasized Syro-Anatolian cultural priority even in the face of political domination. Beyond the fusion of iconographic tropes in isolated artworks, this chapter surveys the archaeological record of Syro-Anatolian cities that continued in use past the Assyrian conquest, demonstrating that in nearly all cases these cities' architectural traditions were unmolested even while new Assyrian buildings were constructed, such that these cities themselves became hybrid entities of Assyrian and Syro-Anatolian cultural production.


The methodology for building and analyzing models of complex systems, based on the connection of co-gnitive modeling and fuzzy set theory within the framework of the concept of "Soft Computing", allows you to combine the advantages of both approaches in solving complex problems of analysis and management. But, despite active research in the areas considered, the issues of analyzing the state dynamics of complex systems based on non-clear cognitive models are not sufficiently developed. The theory and practice of applying fuzzy sets in cognitive modeling is not focused on calculations characteristic of complex systems. Consider an approach to analyzing the state dynamics of complex systems based on fuzzy cognitive models, which allows taking into account the features of non-linear behavior of simulated systems. Propose a model and method for analyzing the state dynamics of complex systems based on generalized fuzzy production cognitive maps. An approach to analyzing the state dynamics of complex systems based on fuzzy cognitive modes is considered, which allows taking into account the features of non-linear behavior of simulated systems. The model and method of analysing the state dynamics of complex systems based on generalized fuzzy production cognitive maps are proposed. The steps of this method are shown. Solutions are shown, due to which the presented model of system state dynamics on the basis of PCMS allows to significantly reduce the model dimension.


The invention provides a webpage access data processing method and a webpage access data processing device. The processing method includes determining historical data corresponding to a first time period; determining first access data of the first time period and a confidence interval of the first access data according to the historical data; extracting second access data of the first time period from a database, wherein the second access data refer to recorded webpage access data of a user terminal; judging whether the second access data are in the confidence interval of the first access data or not; if not, judging that the recorded second access data are abnormal; if yes, judging that the recorded second access data are normal. By the webpage access data processing method and the webpage access data processing device, the problem of incapability of judging whether the user access data are abnormal or not in the prior art is solved, and the effect of judging abnormal user access data accurately and timely is achieved.


cervical carcinoma is considered the second most common cause of gynecological malignancy death following ovarian carcinoma. The incidence of invasive cervical cancer is higher in low-income countries due to lack of screening programs. There are many treatments for cervical carcinoma, namely surgery, chemotherapy and radiotherapy with different morbidity and survival rates (also according to the stage of the disease).

 The aim of this work is to review the cervical cancer patients in Ain Shams University Maternity Hospital from 2012 to 2017 in the aspects of demographic characteristics, treatment modalities used, survival and morbidity.

 the data includes patients diagnosed as having cervical cancer from 1-1-2012 to 31-12-2017 in Ain Shams University Maternity Hospital as retrospective analytical study. We collect name, age, parity stages, Histopathology, treatment, morbidity and survival about each woman and analyze this data.

 study included 147 women diagnosed as having cervical carcinoma from 2012 to 2017 in Ain Shams University Maternity Hospital. the most frequent residence was greater Cairo (81%). Majority of patients and their husbands were illiterate (91.8%). Two thirds of the studied cases were married (66.7%). Less than two thirds of the studied cases were postmenopausal (64.6%). The mean age of cases included in this study was 52.3 years. SSC was the most frequent pathology (82.3%). the overall survival rate was 61.7% (survival duration 1.2year with IQR (1→ 2.5 year). By the end of our study 81.8 % of the cases survived in stage I, 65.7 % in stage II, 55.6 % in stage III and 33.3 in stage IV. The most frequent treatment modality was primary radiotherapy without surgery 53.2% with 60% survival with median duration 1year (0.8-2 year) .Then primary radiotherapy with surgery 22.5 % (19.8 % with completion surgery and chemotherapy and 2.7% with salvage surgery) with 56.2 % survival with median duration 1.1 year (1-2.5 year) and the least frequent was 1ry surgery (21.6 %) with 80% survival with median duration 1.8 year (1-3.9 year). Recurrence was in less than tenth of cases (9.3%), the most frequent site was extrapelvic (75.0%).

 In Ain Shams University Maternity Hospital the cases are usually clinically presented in late stages and usually with complications due to lack of screening. In developing countries like Egypt, brachytherapy may not be available for all patients. Our study proved that completion surgery after whole pelvic radiation can take place with comparable survival rates and morbidity. Our survival rates are comparable with other studies conducted in developed countries and are good with our limited resources but are less than other studies performed in developed countries.


The problem of cracks of traction gear covers for DF 4B diesel locomotives has always been serious, especially in winter, thereby influencing the normal locomotive operation. The recommended method and suggestions conform to actual situations at the locomotive depot to minimize cracks.


The purpose of this paper is to study the existence and uniqueness of the fixed point of uniformly pseudo-contractive operator and the solution of equation with uniformly accretive operator, and to approximate the fixed point and the solution by the Mann iterative sequence in an arbitrary Banach space or an uniformly smooth Banach space respectively. The results presented in this paper show that if X is a real Banach space and A : X X is an uniformly accretive operator and (I-A)X is bounded then A is a mapping onto X when A is continuous or is uniformly convex and A is demicontinuous. Consequently, the corresponding results which depend on the assumptions that the fixed point of operator and solution of the equation are in existence are improved.


The estimation of the quality of transmission (QoT) in optical systems with machine learning (ML) has recently been the focus of a large body of research. We discuss the sources of inaccuracy in QoT estimation in general; we propose a taxonomy for ML-aided QoT estimation; we briefly review ML-aided optical performance monitoring, a tightly related topic; and we review and compare all recently published ML-aided QoT articles.


Faculty of Veterinary Medicine, Department Physiopathology, University of Science Agriculture and Veterinary Medicine, Splaiul Independentei no.105, 050097 Bucharest; 2 Faculty of Veterinary Medicine, Department Clinical medicine and Hygiene, University Spiru Haret, Bucharest 3 Faculty of Veterinary Medicine, Department Biochemistry, University of Science Agriculture and Veterinary Medicine, Splaiul Independentei no.105, 050097 Bucharest, Romania email@example.com


THIS case is reported to show the value of an X-ray examination of the sinuses in the investigation of recurrent purulent meningitis which may be caused by an osteoma of the frontal sinus. The cause of the meningitis was an enormous osteoma. An osteoma is occasionally seen in a frontal sinus X-ray, but it is usually small and discovered by accident. It usually arises from the posterior wall of the sinus and it may cause sinusitis by obstruction. Rarely it may become large and penetrate the posterior wall of the frontal sinus. When this happens a pneumoencephalocele may be produced (Armitage, 1931; Cushing, 1927). More often the osteoma causes a proptosis by downward extension.


Abstract : Some applications of particle beam generators require repetitive operation. Diodes have been pulsed with a repetition rate of 30 Hz; however, investigations of short-time (100 mu sec) multiple pulses are sparse. Using inductive storage techniques to generate a diode electron beam combined with cascade switching permits the use of inductive energy sources for short pulse-to-pulse operation of diodes. Investigations related to generation of electron beams of modest energy and current (100000ev, 1000A) with a voltage pulse inductively produced by exploding wire switches were carried out. Techniques for and results of studies of diode recovery properties are reported. Circuits were developed for switching a second pulse to the diode with a pulse separation of 10-500 mu sec.


The surface glass-transition temperature (T s g) in monodisperse polystyrene (PS) films was examined on the basis of the temperature dependence of the lateral force at a given scanning rate. T s g of the PS films was found to be markedly lower than the corresponding bulk glass-transition temperature over the entire molecular weight range (4900-1,460,000). Also, the apparent activation energy of the surface segmental motion in the PS films was 230 ± 10 kJ mol 1 , significantly smaller than that for bulk PS. Finally, T s g measurement by lateral force microscopy was applied to binary PS mixtures with different molecular weights. On the basis of the Gordon-Taylor equation, the surface composition of the shorter component in the blend films was successfully obtained.


The paper deals with the analysis of price changes of roundwood (spruce, fir and beech sawlog, fuel - wood) and energy wood in Slovakia, Czech Republic and Austria during the period of 2008-+September 2011. At the beginning of the article, the authors identify the major factors influencing timber price trends such as legislation regarding technical standards for the quality grading of round wood, global economic recession, incidental felling and political influence. Consequently, detailed analysis of timber price changes in selected European counties is provided by means of line graphs. The results of the analysis revealed that demand for wood and wood products began to de - crease in mid-2008. The most critical situation was in 2009, primarily in the softwood market, when prices bottomed out. However, recent trends indicate a gradual rise in timber prices. In the future, a slight increase of timber prices is expected, however other factors (such as economic development, lobbyist pressure, incidental felling and many oth - ers) may influence prices, which makes it difficult to predict their trend.


We propose a new digital method for tracking position of particles from in-line holograms by using single wavelet coefficient. By computing a wavelet transform of the 1-D intensity profile of a hologram, resultant wavelet coefficients provide space-varying frequency information of an interference pattern. Our study finds that a dilation which is given by the maximum value of the real wavelet coefficient appeared at the center position of the interference pattern is determined by a recording distance and a wavelength of a coherent illuminating light. Therefore, this dilation can be used for extracting the recording distance of particles from the holograms. A feasibility of this method is experimentally verified by analyzing holograms of a line object.


Hyperammonemia in critically ill newborn is a life-threatening condition that occur due to block at some point in the normal metabolic pathway caused by a genetic defect of a specific enzyme. Some of these disorders are potentially reversible; others are amenable to long-term therapy if early diagnosis and aggressive management in the neonatal period can prevent the catastrophic neurologic deterioration that accompanies massive hyperammonemia. Early recognition of these conditions is important for proper management.


The invention discloses an interlock foldable stroller seat and relates to the technical field of children products. The technical problem of worse safety in use of existing technology is solved. The interlock collapsible stroller seat comprises a backrest part, a seat part, an interlock foldable mechanism and a limit locking mechanism. The backrest part is flexibly connected with the seat part and the backrest part and seat part both can relatively rotate around the flexible connected portion. The interlock collapsible mechanism is arranged between the backrest part and the seat part. The backrest part rotates around the flexible connected portion towards the direction deviated from the front of the seat part and near the back of the seat part, when the backrest part rotates to the folding portion, the seat part can be drove to rotate towards the direction deviated from the front of the backrest part and near the back of the backrest part to the collapsing portion of the seat part. The interlock foldable stroller seat is applied to improve the safety of stroller seats and allows interlock opening and folding to be achieved.


A black-and-white infrared (0.9 to 2.2 μm) video camera, filtered to record radiation within the 1.45 to 2.0 μm mid-infrared water absorption region, was evaluated with ground and aerial studies. Imagery of single leaves of seven plant species (four succulent; three nonsucculent) showed that succulent leaves were easily distinguishable from nonsucculent leaves. Spectrophotometric leaf reflectance measurements made over the 1.45 to 2.0 μm confirmed the imagery results. Ground-based video recordings also showed that severely drought-stressed buffelgrass (Cenchrus ciliaris L.) plants were distinguishable from the nonstressed and moderately stressed plants. Moreover, the camera provided airborne imagery that clearly differentiated between irrigated and nonirrigated grass plots. Due to the lower radiation intensity in the mid-infrared spectral region and the low sensitivity response of the camera's tube, these video images were not as sharp as those obtained by visible or visible/near-infrared sensitive video cameras. Nevertheless, our results showed that a video camera with mid-infrared sensitivity has potential for use in remote sensing research and applications.


Storage tanks from rainwater harvesting systems (RWHs) are designed to provide flow equalization between rainfall and water demand. The minimum storage capacity required to take into account the maximum variations of stored water volumes, i.e., the active storage, depends basically on the magnitude and the variability of rainfall profiles and the size of the demand. Given the random nature of the variables involved in the hydrological process, probability theory is a suitable technique for active storage estimation. This research proposes a probabilistic approach to determine an analytical expression for the cumulative distribution function (CDF) of the active storage as a function of rainfall moments, water demand and the mean number of consecutive storm events in a deficit sub-period. The equation can be used by developers to decide on the storage capacity required at a desired non-exceedance probability and under a preset water demand. The model is validated through a continuous simulation of the tank behavior using rainfall time series from Milan (Northern Italy).


With winning advances like catch of Things, Cloud Computing and Social Networking, mammoth proportions of framework traffic associated information area unit made Intrusion Detection System for sort out security suggests the strategy to look at partner unapproved access on framework traffic. For Intrusion Detection System we are going to call attention to with respect to Machine Learning Approaches. it's accomplice rising field of enrolling which can explicitly act with a decent arrangement of less human affiliation. System gains from the data intentionally affirmation and makes perfect objectives. all through this paper we keep an eye on zone unit going to separated styles of Machine Learning pulls in near and had done relative examination in it. inside the last we keep an eye on territory unit going to foreseen the idea of hybrid development, that might be a blend of host principally and framework based for the most part Intrusion Detection System.


The low-temperature molecular mobility has been studied by dielectric relaxation spectroscopy on the bulk films of statistic copolymers of vinylidene fluoride (VDF) with tetra- (TFE) and trifluoroethylene obtained by crystallization from a solution in acetone. The results show that activation energy of the kinetic units in the glassy state depends significantly on the concentration of polar groups. The cooperative mobility above the glass transition temperature is described by Vogel-Tamman-Fulcher equation; the lowest value of the effective activation energy was found in the copolymer with highest amount of non-polar TFE content. It has been shown that the parameters of the dynamics are related to the structural parameters obtained by infrared spectroscopy, wide-angle X-ray Spectroscopy, and small-angle X-ray scattering. In particular, the largest crystals and the highest value of the "large" period have been detected in VDF/TFE copolymer with lowest activation parameters of microbrownian and local mobility. Number of lamellar crystals in stacks is determined by the concentration of VDF polar groups in copolymer chain.


The paper is devoted to the definition of the role of culturological education in forming of schoolchildren's sociocultural competence. The main features of culturological education are revealed in the context of Russian education modernisation. The author defines the "sociocultural competence" notion and the interrelation of these phenomena within the school education process.


Apprenticeship learning based on inconsistent demonstrations is presented in this paper. We address a problem where given demonstrations are not directly applicable to reward function estimation due to the non-stationarity of an environment or the difference between the dynamics of a robot and a demonstrator. A basic idea of the proposed method is to use a subset of the trajectories sampled from the baseline policy as training data for inverse reinforcement learning. All consistent sample trajectories and inconsistent demonstrations are abstracted by an affine transformation invariant feature. Using the feature, the importance of each sample trajectory is estimated. Rating the sample trajectories based on importance, the training data for inverse reinforcement learning are identified. The validity of our approach is verified through simulation in two scenarios: inconsistency caused by variation of an environment and performance of a robot.


The aims of the study are 1) to describe how dangling modifiers are used by the students in writing Research Findings and Discussion and 2) to give a solusion of the dangling modifiers produced by them. ?e?aThis study is descriptive qualitative research. The object of the study is the Final Projects, especially Research Findings and Discussion Chapter written by the English Education Department Students of University of PGRI Semarang in the academic year 201 3/201 4. The total number of the sample is 30 Final Projects, and purposive sampling is used in getting the sample. In collecting the data, the writers used non interactive method that is in the form of documentation. There are three components used in analyzing the data?oOe¼OCOreducing the data, presenting the data, and drawing conclusion . The result of this study shows that the writers found 39 sentences of the 22 Research Findings and Discussion indicated dangling modifier. There was no dangling modifier in 8 Research Findings and Discussion. The sentences indicated dangling modifier started with present participle, past participle, to infinitive, dan prepositional phrase. The dangling modifiers are because the inroductory phrases of the sentences did not refer to the subjects of the main clauses. In other words, the subjects of the main clauses did not match with the introductory phrases of the sentences or the parts ofmain clause were in the form of expletive construction or passive construction ; as a result, thesubject s were not clear. In solving the problems of the dangling modifiers, the writers changed the subjects of the main clauses, so these matched with both the introductory phrases (modifiers) and the main clauses or added subordinating conjunctions and subjects (doer of action) on the introductory phrases, so these phrases became complete introductory clause s ( adverbial clause ) . Then it is suggested for the advisors to i mprove the quality in guiding the students to write Research Findings and Discussion both in techniques to write them and/or the structures of the sentences, so the students can minimize the errors in writing sentences, especially dangling modifier. ?e?a Keywords: analysis ,dangling modifier, Reserach Findings and Discussion


Abstract The "cerrado" biome in central Brazil is rapidly being converted into pasture and agricultural crops with important consequences for local and regional climate change and regional carbon fluxes between the atmosphere and land surface. Satellite remote sensing provides an opportunity to monitor the highly diverse and complex cerrado biome, encompassing grassland, shrubland, woodland and gallery forests, and converted areas. In this study, the potential of Terra Moderate Resolution Imaging Spectroradiometer (MODIS) data is analyzed to discriminate among these diverse cerrado physiognomies and converted pastures based on their seasonal dynamics and phenology. Four years (2000–03) of MODIS 16-day composited, 250-m resolution vegetation index (VI) data were extracted over a series of biophysically sampled field study sites representing the major cerrado types. The temporal VI profiles over the cerrado formations exhibited high seasonal contrasts with a pronounced dry season from June to August and a w...


Usability testing is often viewed as a way to improve the usability of products. Testing can, however, have a larger, long-range influence on the way an organization develops its products. As a test specialist, you can use a usability test or set of tests to diagnose such factors as the effectiveness of product design technologies, the technical and managerial skills of the people who produce products, and how well the members of a design team are working together. To make diagnoses at this level, you must keep a focus on the underlying causes of the strengths and weaknesses of the usability of products. To have a long-range impact on the way an organization develops products, usability test specialists need to view themselves as change agents. You must involve designers in test planning and execution, and write reports that speak about the underlying causes of the problems users have with products.


Ecological base flow is a basic requirement of water flow for a healthy river ecosystem. But in Weihe River the ecological flow is not guaranteed because of the water shortage, high sediment concentration and considerable agricultural water use along the river. In this study, Baojixia under-tableland irrigation area was selected as a representative area to which a mathematical model of one-dimensional steady water non-uniform sediment regulation was applied, to analyse the impact of channel desilting on guaranteeing the ecological base flow of Weihe River. The results indicated that scouring and silting of the channel was significantly correlated with the channel water capacity and sediment content in water flows. In addition, channel desilting contributed to 55.9×10 4 m 3 and 79.2×10 4 m 3 water saving in the irrigation area in January and December which belonged to the dry season. Their contribution rates to basic flow were 3.5% and 4.9%, respectively.


D'Arcy Thompson was a true pioneer, applying mathematical concepts and analyses to the question of morphogenesis over 100 years ago. The centenary of his famous book, On Growth and Form, is therefore a great occasion on which to review the types of computer modeling now being pursued to understand the development of organs and organisms. Here, I present some of the latest modeling projects in the field, covering a wide range of developmental biology concepts, from molecular patterning to tissue morphogenesis. Rather than classifying them according to scientific question, or scale of problem, I focus instead on the different ways that modeling contributes to the scientific process and discuss the likely future of modeling in developmental biology. Summary: This Review explores how modeling-based approaches can aid our understanding of developmental processes such as molecular patterning and tissue morphogenesis, highlighting their advantages and limitations, and their crucial role in future research.


In this paper, a novel mm-wave beam-steerable antenna with ferroelectric substructure is presented. Ferroelectric substructure is placed under grounded substrate of antenna and coupled with it by three slots etched in internal metallic sheet. The radiation pattern control capability is demonstrated by varying the permittivity of the ferroelectric substructure. The proposed antenna is an excellent solution for a low-cost mm-wave beam-forming due to high radiation efficiency, high gain, low-profile, and low cost of fabrication.


This study aims to evaluate the effect of using local bioactivators rumen contents consisting of local microorganism extract and crude enzymes on crude fiber, crude fat and The Extract matter without nitrogen content of palm fronds. The research was conducted by an experimental method using factorial design in RAL with 2 X 3 and 3 replications for each treatment. Factor A is a type of local bioactivator consisting of A1 = MOL, A2 = crude enzyme. Factor B is the dose of bioactivator, B1 = 10%, B2 = 20%, B3 = 30%. The results showed that there was no interaction between the dose and type of bioactivator on the content of crude fiber, crude fat and Extract matter without nitrogen of palm fronds.


Background : The aim of the study is to evaluate the difference of immunophenotypes of stromal cells between the pure phyllodes tumor (PT) type and the co-existent type of phyllodes tumor and fibroadenoma, and between benign and malignant PT. Methods : Immunohistochemical staining for actin, CD34, CD10, c-kit, bcl-2, p53 and MIB-1 was performed using tissue microarray blocks that contained 25 cases of pure PT (16 benign tumors, 4, borderline malignant tumors, and 5 malignant tumors) and 6 cases of co-existent type. Results : The expression rates of CD34 and MIB-1 in the pure PT type were significantly higher and the expression rate of actin in the pure PT was significantly lower than that of the co-existent type. However, there were no significant differences in the bcl-2, CD10, and p53 expressions between the pure PT type and the co-existent type, and no c-kit expression was observed in both types. No significant differences in the CD34, actin, bcl-2, CD10, and p53 expressions between the benign and borderline/malignant PT cases were found. However, a significant difference of the MIB-1 expression rate was noted. Conclusions : The stromal cells of the pure PT type are regarded as less mature myofibroblasts, and the CD10 reactivity in some phyllodes tumors suggests a myoepithelial origin. The MIB-1 labeling index would be useful for the grading of phyllodes tumor.


This paper studies the surface quality of tool,in last precise cutting in LS - WEDM multi cutting processing,the author attempts to cut in gas and has carried on the contrast experiment to conventional WEDM multi cutting processing. We confirmed reasonable parameters of servo voltage and feed speed of worktable in gas through experiments. Contrast experiment shows the results that new processing craft has superiority of roughness and straightness to conventional processing craft.


By using remote sensing data, temporal and special change of mineral distribution as well as environment variation at the Liuhuanggou mineral district was extracted. Spatial analysis, field work and statistical methods were employed to study dynamics of mineral development and corresponding eco-environment effect. A quantitative analysis model (time span: 1975 - 2004) of mineral development and subsequently eco-environmental effect was constructed, and environmental problems caused by mineral development were explored. Furthermore, those problems were also revealed straightforwardly by the thematic maps of mineral distribution and corresponding eco-environment variation in this study. Magnitude and tendency of land use change imposed by mineral development during the recent 30 years were discussed. Based on the study, policy suggestions were put forward.


Given the public lopsided view on scientific populazation,university undergraduates who are unusually lucky among others have become implicitly group ignorant of popular science,and as a result the compass becomes the "blind spot" in populating science.To further enhance the students' scientific literacy and prepare talents with innovative spirit and ability,it is necessary to carry out the education of scientific populazation in colleges and universities.The paper takes Chongqing University's Association for Science and technology as an example to discuss the theoretical and practical innovation in scientific population.


The article used 2-propanol?benzophenone and phase-transnsfer catalyst bromize four butyls ammonium ed. to synthesized photosensitive solicitation reagent,2-hydroxyl-2-methyl-1-phenyl aceton ssythesize.This teachnique had many strongpoint.Experimentation's instrument and condition were simpieness.The material was cheap and facile.The cost was economical.The transform rate was increased. The technique mitigated surrounding's pollute and increased economy benefit.


For nonlinear systems with state inequality constraints, the existing unscented recursive filtering methods utilize the constraint information in the sampling and update steps, rather than the prediction step. In practice, the constraints are known a priori and they are always satisfied by any true trajectory. To sufficiently incorporate the valuable information, this paper proposes a constrained unscented recursive filter, which applies the constraints to the whole filtering procedures. First, the constrained dynamic model is constructed by using the system projection technique, which optimally fuses the constraint information and the unconstrained dynamics. Next, the state evolutions of general inequality constraints and their special forms are derived, including linear inequality constraints (LIEC), quadratic inequality constraints (QIEC), and coexistence of LIEC and QIEC. Especially, it is proved that the dynamic model with constraints has a smaller uncertainty than the one without constraints, implying that introducing inequality constraint information definitely improves modeling accuracy. Finally, the numerical simulations in the context of target tracking verify the superiority of the proposed unscented recursive filter over the typical constrained ones for inequality constrained systems.


Abstract : The risk of decompression sickness increases sharply if you go deeper, stay longer or surface more rapidly than recommended by accepted dive plan guidelines. And even if you do obey all the rules, the risk of bending is never zero. So, wouldn't it be nice if there were some way to help increase your level of safety?


As part of a national quality assurance programme of the Cercl'Air in cooperation with the Swiss Federal Office for the Environment (FOEN) and the Swiss Federal Office of Metrology (METAS) there have been intercomparisons of air quality monitoring stations of interested institutions in regular intervals since 1988. The former approach, alternating between calibrations with test gases of measuring stations on site and gathering mobile measuring units for additional comparative measurements every second year, had to be modified as mobile measuring stations have become increasingly sparse over the last years. The idea was to find a solution to combine the two types of intercomparison in one campaign. The problem was solved by assembling a mobile reference station for measuring air pollution, with the addition of equipment to provide test gases for the candidate instruments. With this mobile measuring unit, calibration with test gases and comparative measurements could be performed on site at the candidate air pollution monitoring stations. The results of the 2007 intercomparison campaign showed that the achieved quality improvements in air pollution measurements over the last twenty years - decrease of expanded uncertainties in intercomparisons by a factor of 4 to 7 depending on the type of pollutant - could be sustained.


Previous literature has examined natural remission rates from problematic drinking in the general population, but not in heroin and cocaine users. This study is a cross-sectional, retrospective study of the baseline data from the Baltimore site of the NEURO-HIV Epidemiologic Study focusing on self-reported substance use. It is one of the first efforts to identify levels of drinking severity and natural recovery in this population and explores possible rationales for the differences between conditions from non-clinical samples. The sample consisted of 338 participants who reported active heroin and/or cocaine use and having had a period in their lives when they engaged in problematic drinking behavior. Active heroin and cocaine users were divided into three groups based on current levels of alcohol use: abstainers, moderate, and problematic alcohol users. In this study, 69.2% of current heroin and/or cocaine users reported that at one time in their lives they engaged in problematic drinking behavior, but currently were no longer doing so. That is, 59.5% of the current heroin and/or cocaine users reported natural recovery from problematic alcohol misuse. Further, as drinking severity increased, prevalence of injection drug use decreased, while prevalence of snorting/sniffing cocaine increased. The recovery process from problematic alcohol use may provide strengths which could translate into recovery from other more hazardous substances. The authors call for research to explore which cognitive or environmental factors allow active heroin and cocaine users to achieve natural remission from problematic alcohol use beyond that seen in a non-clinical sample.


A vanadium dioxide (VO2) based solid-to-solid phased changing material has been attracting great interest in smart window applications. However, achieving high solar modulation and high transparency simultaneously in visible light is the major challenge for the practical application of this smart material. To resolve this issue, in this paper, a smart film composed of a VO2 nanoparticle matrix and a patterned VO2 film is presented. Numerical modeling and electromagnetic simulation are carried out to characterize the performance in terms of solar modulation and luminous transmittance, and a parametric study is carried out to optimize the proposed smart window film. Compared with the VO2 nanoparticle matrix, the proposed structure can obtain 23% solar modulation and 57% luminous transmittance but with a much thinner thickness, which will significantly reduce the cost and fabrication complexity and extend the environment stability.


We don't often think about vitamin D deficiency in our patients, but this study suggests that hypovitaminosis D is common -- at least among adult


Environmental pollution due to heavy metals is a world-wide problem in estuarine, coastal and marine waters. Metal pollution affects different organisms in different ways and the degree of the impact is site-specific. Aim of the present study was to determine the effects of heavy metals viz., Cu, Cd and Pb exposure on tissue accumulation, pigmentation and productivity of two marine macro algae, Fucus vesiculosus and Ulva lactuca under controlled laboratory conditions. Algae were collected from a reference location, Wemeldinge in the Eastern Scheldet Estuary in Netherlands. Metal concentrations were determined using ICP-MS. Productivity of algae was measured using Winkler method and the results were expressed as carbon equivalent. Pigment profiles of two species were analyzed by spectral absorbance over 250 -1100nm range. The results revealed that the metal accumulation in tissues significantly increased with increasing exposure to metal concentration whereas, pigmentation, and photosynthetic productivity decreased with increasing metal concentration. Hence, F. vesiculosus and U. lactuca could be used as bio-indicators to determine metal pollution in coastal waters.


This ancillary study examined the impact of depressive symptoms on the effectiveness of a urate‐lowering therapy in the context of a clinical trial.


The heats of vaporization of 1-methylcyclopentene, 3-methylcyclopentene, ethylidenecyclopentane, 1-ethylcyclopentene, methylenecyclohexane, allylcyclopentane, vinylcyclohexane, ethylidenecyclohexane, allylcyclohexane, 3,3-diethylpentane, 2,2,4,4-tetramethylpentane, and trans-2,2,5,5-tetramethyl-3-hexene have been measured by the gas chromatography – calorimetry method. These values have been combined with previously reported liquid heats of formation to give gaseous values of ΔHf. The results indicate that the internal double bond is favored by about 0.5 kcal over the exo in both 5- and 6-membered rings, but the endo–exo differences are much smaller than previously believed. Several of the liquid heat capacities that were measured were not well predicted by group additivity schemes.


In this study, a series of composites comprising polyether ether ketone (PEEK) and carbon fiber (CF)-reinforced polybenzoxazine for high-temperature friction materials for vehicle brake applications were developed using a high-temperature compression molding technique. The objective of this research was to systematically investigate the thermal, mechanical (tensile and flexural), and tribological performance of friction materials made from polybenzoxazine-based composites by varying the PEEK/CF mass ratio. Our study reveals the substantial improvement effect of the increased content of PEEK fibers on the thermal conductivity, the coefficient of friction, and the friction strength of the polybenzoxazine-based composite materials. Meanwhile, the introduction of carbon fibers was found to have a monotonic positive effect on the mechanical (tensile and flexural) properties and wear performance of the polybenzoxazine-based composites. The polybenzoxazine-based composites exhibit high mechanical strength, with a tensile strength of 50.1–78.6 MPa, Young's modulus of 10.2–24.3 GPa, a flexural strength of 62.1–88.3 MPa, and a flexural modulus of 13.1–27.4 GPa. In addition, the polybenzoxazine-based composite with a PEEK/CF mass ratio of 75:25 exhibits a high and stable coefficient of friction (0.33) and a specific wear rate (1.79 × 10−7 cm3/Nm at room temperature). Subsequent to the wear test at ambient temperature, the worn surfaces of five polybenzoxazine-based composite samples with various PEEK/CF mass ratios were studied using electron microscopy technology (SEM). The observation of small cracks and tiny grooves on the worn surfaces indicates a combined abrasive and adhesive wear mechanism of the material. Our experimental results clearly reveal superior mechanical properties and excellent tribological characteristics. As a result, these composites show promising potential for the application of friction materials in terms of vehicle braking system applications.


This merger and acquisition scenario explores negotiation through several lenses: preparation, negotiation as an art, valuation, tribal marketing and the freak factor. Preparation, especially with a best alternative to negotiated outcome is critical in setting the stage for negotiation. Negotiation as art presumes a need for practice and personal understanding of the situation. Valuations are never perfect, with each party having a bias. Tribal Marketing looks at the organizational dynamics and considers how firms can create support by letting stakeholders integrate themselves into the company. The Freak Factor assesses that a firm's strength is found in its weaknesses, success is found in magnifying strengths rather than balancing outs a weakness. The working paper uses fictional corporations to simulate and apply real situations. New Star Technologies is a venture capital backed biotechnology firm specializing in developing antigens for vaccines. The firm is loosing five million Euros a month, internally valued at 200 million Euros, and is developing a promising antigen for use in an AIDS Vaccine. New Star must become cash flow positive. Blue Bio is a publicly traded firm with a market capitalization of fifteen billion Euros; its research and development projects span many aspects of biotechnology. Blue Bio is expanding through acquisitions of smaller firms to develop research synergies and to build and international brand.Based on a student trail of this scenario, Piratical Suggestions include: Preparation is critical in negotiations; management should include diversity in negotiation planning. Valuations are never perfect; management should include brand valuation and consider the cost of cultural integration with the new firm. Tribes create value to the firm; management can promote the tribe by releasing control to stakeholders. Tribes are smart; management builds trust with the tribe by fostering open communication. Building on strengths maximizes value; management should recognize that weaknesses are keys to strengths.


Objective: To evaluate the 24-hour Holter ECG recording in hypertensive heart disease.
Methods: This was a descriptive and analytical cross-sectional study on files of patients with hypertensive heart disease, carried out from October 2016 to October 2019, in two health facilities in Lome (TOGO). Electrical left ventricular hypertrophy (LVH) was defined by the Sokolow-Lyon and Cornell indices. On echocardiography, the HVG according to the criteria of the American Society of Echocardiography, was the characteristic retained for a CH. Holter-ECG recordings were carried out over 24 hours by two Holter devices.
Results: 107 patients were included, with a sex ratio of 1.89 (M / F). The mean age was 62.2 ± 12 years. The mean duration of the evolution of hypertension was 10.8 ± 9.1 years. On standard ECG, arrhythmias were more frequent (32.6%) with ACFA in 5.6% of cases. The prevalence of echocardiographic HVG was 74.8%, predominantly concentric, and was significantly found in hypertensive patients over 10 years of age. During the 24-hour Holter ECG recording, ACFA was the common arrhythmia (30%), episodic in 90.6% of cases and permanent 9.4% and was statistically associated with OG size, sex and age. The Holter ECG detected sustained ventricular tachycardia in 7 patients (6.5%). The Recording was normal 12.1% of the time.
Conclusion: Hypertensive heart disease is the first of the cardiac complications of hypertension. The Holter ECG is a tool for the detection of fatal severe paroxysmal events that go unnoticed on the surface ECG such as AC/AF, sustained ventricular tachycardias.


A new type of electrometric AC-DC transfer standard is now under development at IEN. In this paper, the theory of this device and an analysis of the impact of some physical effects on the AC-DC difference, the description of the prototype, and preliminary experimental results are presented. The electrometric AC-DC transfer standard can now operate at the same level as resolution of thermal converters, even without the control of the distance between the electrodes. The measurements performed by the instrument are compatible with those obtained by means of calibrated thermal converters.


Objectives: Using the method of meta-analysis to compares and analyzes the development characteristics of children's FMS in countries with different development levels from the perspective of gender. Methods: We searched the PubMed, EBSCOhost, Embase and Web of Science databases for studies published up to April 5, 2021, empirical studies on the FMS of children aged 3-6 were included. Two researchers independently screened and extracted data according to inclusion and exclusion criteria. RevMan 5.4.1 software was used for meta-analysis to analyze the mastery level of global children's FMS. Results: Finally, 18 articles were included. Results of the meta-analysis showed that whether in developed or developing countries, there was no statistical significance in comparing the locomotor skill scores of boys and girls (all P > 0.05); however, both in developed countries and developing countries, the scores of object control skills generally appears that boys are better than girls (Developed: 0.48 [95% CI 0.40, 0.56], Z=11.74, P<0.05, I=0%; Developing: 0.53 [95% CI 0.30, 0.76], Z=4.53, P<0.05, I=81%). Conclusion: From the perspective of gender, the developmental characteristics of FMS in children showed consistent patterns in countries with different development levels. There is no difference in the mastery of locomotor skills among children of different genders, but there is a significant difference in the mastery of object control skills, and boys are significantly better than girls.


Recycled plastics are considered as materials with physical, mechanical and aesthetic properties worse than the virgin ones. In fact, this is true because degradation during lifetime and during the recycling operations changes the structure and the morphology of the polymers and then the final properties of the secondary material. Several strategies are under investigation, and in some cases also applied, in order to avoid further degradation during recycling and, if possible, to repair the macromolecules broken during lifetime and then to restore or to improve the initial properties. In this paper the more important techniques, already used in industry or under investigation, according to this philosophy are shortly reviewed.


Purpose: To improve the production of a novel exopolysaccharide (EPS) by Bacillus mucilaginosus CGMCC5766. Methods: The culture medium for production of EPS was optimized using statistical experiment design. Sucrose, CaCO 3 and K 2HPO 4 were found to be the key factors based on the results obtained from Plackett‐Burman experimental design. The optimal concentration range of the three factors was examined by the steepest ascent path, and then the optimum concentration was further investigated through response surface methodology. Validation experiments were also carried out to establish the adequacy and accuracy of the model obtained. Results: Under optimal conditions (sucrose 61.31 g/l, CaCO 3 5.06 g/l and K 2HPO 4 0.17 g/l), EPS concentration achieved 22.04 g/l, which was about 1.6-fold increase compared with that using the original medium. EPS concentration in 5-l fermenter reached 23.46 ± 0.76 g/l. Conclusion: The optimization medium is considered fundamental and useful for the development of B. mucilaginosus CGMCC5766 cultivation process for efficient production of EPS on a large scale.


Objectives. It is known that a great extent of radiation is emitted from the medical instruments used in hospitals and that radiation exposure can cause thyroid cancer. However, the correlation between occupational radiation exposure in hospitals and thyroid disease is not extensively recognized. Methods. The subjects of the study were female nurses, who worked at a single hospital and female, who had undergone a health examination at the same hospital during the same period. The 1,024 nurses and 2,631 healthy women were enrolled for the present study. All the participants were screened using thyroid ultrasonography, and fine-needle aspiration & cytology was performed on potentially malignant nodules. Results. Thyroid nodules were present in 315 nurses (30.8%) and 1,023 health check-up female (38.9%). Typically, 107 nurses (10.4%) and 201 health check-up female (7.6%) had suspicious nodule and were further tested with ultrasonography guided fine-needle aspiration & cytology. The 16 nurses (1.6%) and 38 health check-up female (1.4%) were diagnosed with thyroid cancer. The prevalence of thyroid nodules was enhanced in both the groups and a significant increase was noted in health check-up female group (P<0.05); however, no difference was seen in the incidence of thyroid cancer in both the groups (P>0.05). Conclusion. In our study, working in a hospital does not increase the prevalence of thyroid nodules or thyroid cancer.


synopsys.com Synopsys S-Metro is a comprehensive and powerful tool for automated metrology data import, image processing, contour extraction, visualization, and analysis. Lithography process engineers use it to assess and visualize critical dimension (CD) metrology data. S-Metro determines key measures that characterize the performance of the lithographic process, such as process window size or exposure latitude. Multiple datasets are analyzed individually, and the overlapping (or common) process window is reported.


Practical aspects of linear regression modeling are reviewed, explicitly incorporating knowledge about the signs and ordering of the regression parameters. Statistical properties of equality and inequality constrained estimators are presented. This co..


Chrome leather shavings were used to prepare adsorbent for removal of aromatic organic acids from aqueous solution. Benzoic acid, o-, m-, and p-phthalic acids, salicylic acid and p-hydroxyl benzoic acid, which are common pollutants in waste water, were used as adsorbates in this study to investigate the sorption behavior of the adsorbent made from chrome leather waste. It was found that the sorption capacity of aromatic organic acids on the adsorbent depends largely on the molecular structures of these compounds. The sorption capacity of o-phthalic acid on the adsorbent was as high as 2.8mmol/g in experimental conditions, and that of salicylic acid was around 0.41mmol/g. However, no significant sorption was observed in the case of benzoic acid. Sorption isotherms of aromatic organic acids are typically non-linear ones, and can be well fitted by adsorption-partition model. The contributions of adsorption and partition to total sorption of these compounds on the adsorbent were quantitatively described. It was found that, for o-phthalic acid, the function of partition is predominant, and for p-phthalic acid, adsorption plays a key role. As for m-phthalic acid and salicylic acid, the contributions of adsorption and partition to total sorption depend on the concentration of adsorbate. Those results demonstrate that this adsorbent can be applied to remove aromatic organic acids from wastewaters in a wide range of concentration.


To promote teaching reform and connotation construction in higher vocational colleges,the paper discusses reform measures based on actual problems in professional teaching of human resources management,including professional Committee construction,teaching staff with Double Qualified Certifications,optimization of teaching environment,teaching information resources and the system of professional qualification certificates to develop professional and highly qualified personnel in human resources management.


The world's second most populous language family straddles the Himalayas along the northern and southern flanks. The Trans-Himalayan language phylum has been known by various names since it was first recognized in 1823, such as Tibeto-Burman, Sino-Himalayan, Indo-Chinese, Sino-Tibetan and Sino-Kiranti. Each label presumes a different model of phylogenetic relationship. It is high time that empirically unsupported models be discarded. The structure of the language family as a whole is presented with special reference to Sinitic. The Trans-Himalayan model is amenable to accommodating new historical linguistic insights and can better inform other disciplines about ethnolinguistic prehistory than the competing language family models. 现代人类学通讯 2011 年 第五卷 第 135-142页 第二届语言进化与遗传进化国际会议


Objective To treat duodenal ulcer(DU) by step withdrawal of proton pump inhibitor rabeprazole(Rab),and to investigate whether gastrin(GS) is correlated with DU relapse.Methods One hundred patients with DU were randomly divided into two groups.Treatment group(50 patients) were treated with Rab step withdrawal method and control group(50 patients) with Rab conventional therapy.Before the withdrawal,serum GS was decreased to normal levels.The therapeutic efficacy was evaluated by clinical criteria in both groups.Serum GS and DU recurrence were measured 9 weeks and 1 year after treatment to observe the relationship between GS and DU recurrence.Results The efficiency of treatment was 94% and 88% in treatment group and control group,respectively,and no significant differences in the efficiency were observed between the two groups(P0.05).Serum GS levels and DU recurrence in treatment group were significantly different from those in control group(P0.01),but no significant differences in GS levels in patients with recurrence were observed between the two groups(P0.05).Conclusion The method of step withdrawal of Rab for DU can restore normal levels of serum GS and reduce the rate of DU relapse.Furthermore,there is a relationship between serum GS levels and DU recurrence.


This article puts forward a class construction maturity model after the analysis of the present situation of class construction in high vocational college.And the elementary contents of the model are discussed and analyzed on the basis of quoting much literature.


Cameron K (2008) Positive Leadership: Strategies for Extraordinary Performance. San Francisco, CA: Berrett-Kohler. Cameron KS, Dutton JE and Quinn RE (2003) Positive Organizational Scholarship. San Francisco, CA: Berrett-Koehler. Chia R and Holt R (2009) Strategy without Design: The Silent Efficacy of Indirect Action. Cambridge University Press, Cambridge. Fineman S (2006) On being positive, concerns and counterpoints. Academy of Management Review 31(2): 270–291. Harter N (2006) Clearings in the Forest: On the Study of Leadership. West Lafayette, IN: Purdue University Press. Johnson G (2008) Merleau-Ponty, Reciprocity and the Reversibility of Perspectives. In: Weiss G (ed.) Intertwinings: Interdisciplinary Encounters with Merleau-Ponty. Albany, NY: SUNY Press, pp.169–187. Küpers W and Weibler J (2008) Inter-leadership: Why and how to think leaderand followership integrally. Leadership 4(4): 443–447. Leder D (1990) The Absent Body. Chicago, IL: University of Chicago Press. Merleau-Ponty M (1962) Phenomenology of Perception. London: Routledge. Merleau-Ponty M (1995) The Visible and the Invisible. Evanston, IL: Northwestern University Press. Merleau-Ponty M (2003) Nature. Evanston, IL: Northwestern University Press. Segal S (2010) A Heideggerian approach to practice-based reflexivity. Management Learning 41(4): 379–389.


Florida has imported over a million 'Malayan Dwarf7 seed coconuts from Jamaica and has several hundred thousand of these planted in the landscape. Of the three 'Malayan Dwarf varieties (gold, yellow, and green), the golden variety is predominant. Because it requires more care than the lethal yellowing susceptible 'Jamaican Tall' coconut and, by nature, has a lighter green color and golden petioles, many people feel this palm is less desirable and some have even mistaken its normal coloration for lethal yellowing. To demonstrate the importance of nutrition in the growth of golden 'Malayan Dwarf coconut palms, a test was set up in Crandon Park on Key Biscayne, Florida. Both foliar and granular fertilizers were formulated to provide the specific nutrient requirements of the 'Malayan Dwarf. A program for establishing 'Malayan Dwarf coconut palms was deter mined using foliar and granular fertilizer for the initial six months and granular fertilizer alone at 3-4 month intervals to maintain fertility. 'Malayan Dwarf coconut palms respond dramatically to fertilization and, with proper care, are a valuable addition to the tropical look of south Florida. The 'Malayan Dwarf coconut palm (Cocos nucifera L. 'Malayan Dwarf) is known to require more care and fertilization than the 'Jamaican Tall' (Midcap 1975). Early introductions during the 1950's in Dade and Monroe County have survived lethal yellowing, but many of the palms appear to be nutrient deficient. Public acceptance of the 'Malayan Dwarf coconut palm has been lower than antici pated because the horticultural requirements of the palm are different than the common 'Jamaican Tall\ Of the three types of 'Malayan Dwarf coconut palm (golden, yellow, and green) the green appears to be horticulturally the best adapted for south Florida. Early importa tions of 'Malayan Dwarfs' were predominately of the golden iThe author wishes to express his gratitude to Mr. Howard Bardsley (F.E.C. Fertilizer, Homestead, FL) for providing the granular and foliar fertilizer used in this experiment and to Mr. Dick Jones (Dade County Parks and Recreation Dept.) for allowing this demon stration in Crandon Park. Additional thanks are made to Mr. Astor Goodison (Jamaica Coconut Industry Board), Mr. Harry Britt and Mr. Tony Bushell (Crandon Park), Mr. Jesse Durko (ARC, Ft. Lauderdale), and DeArmand Hull (Dade County Extension Service), for their assistance. Additional demonstrations were made at Oglesby Nursery & Gulfstream Country Club. 74 type. Although the golden 'Malayan Dwarf grows well and is almost totally resistant to lethal yellowing its natural golden cast and lighter green color makes it appear to be "underfed". In the past few years the public's preference for green 'Malayan Dwarfs' and the Jamaican Coconut In dustry Board's willingness to sort out and ship Florida seednuts of this type has made this green coconut very popular. With proper care all 'Malayan Dwarf coconut palms will thrive in south Florida. 'Malayan Dwarf coconut palms require the most care during their first few years. When young they may be a little less cold tolerant than the 'Jamaican Tall' and require a well drained soil, good nutrition, and adequate irrigation. The most critical step in determining the success of 'Malayan Dwarf coconut palms in the landscape is during the es tablishment phase after transplanting. Good care during the first 6-12 months after the palm is planted will alleviate many of the problems that can occur later. To determine the importance of nutrition in the growth of golden 'Malayan Dwarf coconut palms a test was set up in Crandon Park on Key Biscayne, Florida. Materials and Methods Because of the special microelement needs of most palms and the unique requirements of south Florida's high pH soils, a special formulation of granular fertilizer was de veloped (Table 1). This high microelement mix is slow Table 1. Analysis of 'Malayan Dwarf Coconut Palm Granular Fertilizer. Plant Nutrient Percent Total Nitrogenz Nitrate Nitrogen Ammoniacal Nitrogen Water Sol. Org. Nitrogen (and/or Urea Nitrogen) Water Insoluble Nitrogen Available Phosphoric Acidz Soluble Potash* Chlorine (not more than) Secondary Plant Nutrientsy Total Magnesium as Mg Water Sol. Magnesium as Mg


Abstract Endogenous glucocorticoids are converted to their biologically inert 11-dehydroderivatives by isoforms of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD). The low-K m, NAD+-dependent renal isoform (Type 2) identified in the distal nephron protects mineralocorticoid receptors from activation by endogenous glucocorticoids. The function of high-K m, NADP+-dependent renal isoform (Type 1) is less well understood. Since glucocorticoids may modulate sodium transport in renal proximal tubules (PT), we hypothesized that Type 1 activity in this segment may be regulated by dietary Na+. 11β-HSD activity was assessed in homogenates of canine PT by the conversion of cortisol to cortisone in the presence of NADP+ 200 μM. A high-Na+ diet for 4 days increased the V max 4-fold, with no change in the Type 1 K m (40 mEq/day Na+ diet: K m 0.959 μM, V max 3.40 pmoles/min/mg protein versus 150 mEq/day Na+ diet: K m 0.962 μM, V max 14.8 pmoles/min/mg protein). Type 1 mRNA also rose in the salt repleted animals. The high-Na+ diet produced no detectable change in the Type 2 isoform enzyme kinetics and mRNA level. No reverse oxo-reductase activity was noted with either renal isoform. Thus, renal Type 1 11β-HSD can be regulated by dietary Na+ independent of changes in the renal Type 2 isoform.


UT-SAFT is one of the well-known reconstruction tools, which pr ovides information about the defect size. In this work we studied the use of phased arr ay technique in combination with the SAFT algorithm to inspect power plant components. As a first exam ple we inspected a real-sized mock-up model representing a part of a reactor pressure vessel wi th a 180 mm-thick ferritic base material followed by a 6 mm-thick austenitic cladding layer. The phased a rray probe was coupled at the outer ferritic surface. We detected and sized artificial cr acks within the cladding with a depth ranging from 4 mm to 10 mm. Secondly, we investigated a mock-up model resembling a nozzle including a thermo sleeve inlet and a maximum wall thickness of about 37 mm. Art ificially inserted notches with a depth of 3 mm could be detected and sized, where the thermo sleeve is welded at the inside of the nozzle.


In this communication, we report on the anisotropy of the superconducting properties of multifilamentary Bi-based tapes experimentally investigated by AC magnetic susceptibility measurements. The susceptibility /spl chi/=/spl chi/'-j/spl chi/'' was measured using a commercial system and a couple of orthogonal pick-up coils. The /spl chi/'' vs. temperature curves were shown to exhibit two peaks. The smaller of the peaks, occurring near T=72 K, was only visible for particular field directions and within a given frequency window. Such results point out the role played by the phase difference between the applied magnetic field and the internal magnetic field seen by the filaments.


Hadronic final states in e+e- and lepton-nucleon collisions QCD in multiparticle production soft hadronic interactions hadron-nucleus and heavy ion interactions interplay between soft and hard interactions polarization in high energy physics cosmic rays neutrino masses future plans.


The principal aim of this research study was to improve the reliability of structural performance prediction for pavement structural condition. The intention of this research was to provide accurate information upon which decisions can be made, regarding when and how a particular road network needs to be rehabilitated, and where the associated budget should be allocated. The project focused on developing structural deterioration models for flexible pavements for the Queensland road network using Traffic Speed Deflectometer (TSD) data collected over a five-years period by the Department of Transport and Main Roads (TMR), Queensland.
The Falling Weight Deflectometer (FWD) is a non-destructive testing device which has been used by many road agencies worldwide since 1980's, primarily for structural evaluation of flexible pavements for pavement design and evaluation of structural integrity. In early 2000, the world's first Doppler based TSD was developed by Greenwood Engineering. Currently more than ten TSD vehicles are in use worldwide. Two main advantages of the TSD technology are its ability to carry out continuous bearing capacity measurements, rather than measurements at discrete points, and the ability to conduct tests at traffic speed without the need for lane closure, as is the case for a stationary device, such as, the FWD.
To achieve the desired outcomes, of this study a comprehensive review of locally and internationally available literature related to deflection data collection, interpretation and analysis was undertaken. This provided a clearer understanding of the research undertaken in the past and closed the existing knowledge gap on structural performance. Furthermore, an initial research study carried out to examine the structural performance of flexible pavements using TSD for network-level analysis, generated some interesting findings that deflection data collected by TSD can be easily transformed into FWD- equivalent Structural Numbers. Additionally, this study has successfully established a correlation between maximum deflections TSD-D0 and FWD-D0 derived from the two devices. In this study, TMR's tolerable-deflection FWD equations are transformed to TSD- based equations through the derived TSD and FWD relationship. Subsequently, a methodology has been developed to predict structural remaining life from the measured TSD deflection data.
The major part of this research was devoted to develop structural deterioration models for flexible pavements for Queensland roads. The structural deterioration model is a critical input in the pavement management system for predicting structural performance and pavement rehabilitation needs. A simple, practically implementable concept was adopted in this study to develop the models. These deterioration models were developed by using five years of time series TSD deflection data as a function of other readily available data through adopting data mining techniques and tools. This study successfully established robust and simple structural deterioration models that will enable road agencies to incorporate available TSD data in the pavement management system for developing network-level pavement investment strategies. Furthermore, the deterioration models were developed as a function of maximum deflection (D0) and adjusted structural number. These models were useful as most of the currently available pavement management software can incorporate these models without making any major changes to the program.
In conclusion, this is the first research carried out in Queensland using a large amount of network level data collected by TSD for developing structural deterioration models. The findings of the research make a significant and original contribution to knowledge and narrow the knowledge gap of practically using structural data at a network level. The structural deterioration models developed in this research will assist road agencies in the sustainable management of ageing road assets and provide them with greater insights into pavement conditions.


Sulfation is an important steroid inactivation in human tissues. Sulfotransferase (SULT) 2B1b selectively conjugates 3β‐hydroxysteroids and is expressed in epithelial cells of normal and cancerous prostate tissues. Dehydroepiandrosterone (DHEA) and Δ5‐androstenediol (Δ5‐Adiol) sulfation prevents their conversion to more potent androgens and estrogens in tissues although both compounds may also be biologically active.


A high-speed ATM/STM hybrid switching network is proposed. The switch employs a multistage interconnection network with local memory to realize the ATM and STM switch together. Different classes of services can use different switch modes. The performance analysis shows that it has excellent delay vs. throughput performance for ATM traffic in the presence of STM traffic and very low blocking and loss probability for STM call requests in the presence of other traffic.


Abstract : The objective of this project was to develop a systematic series of chemical, physical, and mechanical procedures which would allow timely, technically sound and cost-effective screening of new candidate resins which were available in limited quantities.


The integration of atom optics components on a small surface may lead to many new experiments exploring the boundaries of quantum mechanics. Coherent transport of atoms is a key ingredient, and for this reason many groups are developing magnetic waveguides for cold atoms.14 So far the confinement in these guides is rather poor, resulting in the population of many transverse modes. Typically 10 Gauss over 100 pm gives a mode spacing of 40 kHz for Cs atoms4 We have developed a new magnetic waveguide, based on ferromagnetic material. At saturation the surface-field is 1 Tesla, which can be applied over a 10 pm distance corresponding to a mode-spacing of 18 MHz. Our structure is shown in Fig 1. We use a sandwich of mu-metal and copper sheets to generate a magnetic field. An electrical current of up to 5A is running through the copper, encircling the mumetal sheet. This induces an upward or downward field in the mu-metal, similar to a solenoid with a ferromagnetic core. Thin kapton sheets are used to provide electrical isolation. The magnetic field above the mirror is described in more detail in the paper by M. Vengalattore et al, elsewhere in these proceedings. By applying a horizontal bias field parallel to the mirror, and using only the inner set of mumetal sheets ("inner dipole") we create a magnetic quadrupole field above the surface. This is used to trap the atoms using the surfaceMOT tecbniq~e.~ We create a tube-like MOT with a large aspect ratio, shown in Fig. 2. By increasing the bias field the MOT may be moved towards the magnetic surface, at the same


Abstract Flat-band systems have attracted considerable interest in different branches of physics in the past decades, providing a flexible platform for studying fundamental phenomena associated with completely dispersionless bands within the whole Brillouin zone. Engineered flat-band structures have now been realized in a variety of systems, in particular, in the field of photonics. Flat-band localization, as an important phenomenon in solid-state physics, is fundamentally interesting in the exploration of exotic ground-state properties of many-body systems. However, direct observation of some flat-band phenomena is highly nontrivial in conventional condensed-matter systems because of intrinsic limitations. In this article, we briefly review recent developments on flat-band localization and the associated phenomena in various photonic lattices, including compact localized states, unconventional line states, and noncontractible loop states. We show that the photonic lattices offer a convenient platform for probing the underlying physics of flat-band systems, which may provide inspiration for exploring the fundamentals and applications of flat-band physics in other structured media from metamaterials to nanophotonic materials.


Indian Society is bound by duties and responsibilities which are a part and parcel of the country's culture. As India is a place of different cultures, there are certain traditions which are followed by Indians in an astute manner. Manju Kapur, in her novel Difficult Daughters, has portrayed the traditional women of India. Here, she has presented women belonging to three generations. Kasturi follows the tradition by marrying and bearing eleven children and she expects the same from her first daughter Virmati. But Virmati prefers the road which is less traveled. She begins to value education and higher things in life against her parent's wish. The novel is also successful in presenting clearly the abuse that the women face at the hands of society. She wishes to pursue education for herself for which she pays a high price by falling in love with the professor. She finds no meaning in following the tradition or culture that she was


In this work we present a set of guidelines to help designers during the activities of interaction design process to support user-centered approaches. The aim is to guide designers in integrating professional, personal and social contexts of the user during the construction phase of applications that are embedded in the user's workflow. These guidelines were formulated from studies conducted in a Hospital for treatment of chronic mental illness in Brazil. During these studies we observed healthcare professionals in their daily activities and with these information we developed information and communication (technology?) solutions to bring new technologies in their day-to-day while not disrupting their work routines. In the Hospital environments, where our study took place, the healthcare professionals are not familiar with technology and they do not use technologies for their work. We observed, collected and analyzed several data related to the activities of the design process and the designer's work. These analyses helped us in understanding some weak points in the design process that do not simplify the integration of the different contexts in which users are naturally inserted. With the integration of contexts, we promote the extension of user's abilities and the appropriation of technologies and applications, favoring an expanding of the user's abilities involved.


The Metropolitan Water District of Salt Lake and Sandy (MWDSLS) is the owner of an existing 1753 millimeter (inside diameter) water transmission pipeline that begins in Wasatch County, Utah traverses through Utah County and ends at the terminal reservoirs in Salt Lake City. The approximate length of the water transmission pipeline is 67.6 kilometers. The pipeline was approved for design and construction by the President of the United States on October 24, 1938, built by the Bureau of Reclamation (BOR) in the 1940's and turned over to MWDSLS in 1951. (Ref. 1) The Salt Lake Aqueduct (SLA) supplies water to Salt Lake City and Sandy City municipalities. This paper will discuss existing facilities, condition assessment of interior and exterior linings, hydraulic assessment, capacity evaluation, and multi-hazard risk assessments for Level 1 and Level II seismic events as required to develop prioritized replacement projects.


YbbN/CnoX are proteins that display a Trx domain linked to a tetratricopeptide (TPR) domain, which are involved in protein-protein interactions and protein folding processes. YbbN from Escherichia coli (EcYbbN) displays a co-chaperone (holdase) activity that is induced by HOCl (bleach). EcYbbN contains a SQHC motif within the Trx domain and displays no thiol-disulfide oxidoreductase activity. EcYbbN also presents a second Cys residue at Trx domain (Cys63) 24 residues away from SQHF motif that can form mixed disulfides with substrates. Here, we compared EcYbbN with two other YbbN proteins: from Xylella fastidiosa (XfYbbN) and from Pseudomonas aeruginosa (PaYbbN). While EcYbbN displays two Cys residues along a SQHC[N24]C motif; XfYbbN and PaYbbN present two and three Cys residues in the CAPC[N24]V and CAPC[N24]C motifs, respectively. These three proteins are representatives of evolutionary conserved YbbN subfamilies. In contrast to EcYbbN, both XfYbbN and PaYbbN: (1) reduced an artificial disulfide (5,5′-dithiobis-(2-nitrobenzoic acid) = DTNB); and (2) supported the peroxidase activity of Peroxiredoxin Q from X. fastidiosa, suggesting that in vivo these proteins might function similarly to the canonical Trx enzymes. Indeed, XfYbbN was reduced by XfTrx reductase with a high catalytic efficiency (kcat/Km=1.27 × 107 M−1.s−1), like the canonical XfTrx (XfTsnC). Furthermore, EcYbbN (as described before) and XfYbbN, but not PaYbbN displayed HOCl-induced holdase activity. Remarkably, EcYbbN gained disulfide reductase activity while lost the HOCl-activated chaperone function when the SQHC was replaced by CQHC. In contrast, the XfYbbN C40A mutant lost the disulfide reductase activity, while kept its HOCl-induced chaperone function. Finally, we generated a P. aeruginosa strain with the ybbN gene deleted, which did not present increased sensitivity to heat shock or to oxidants or to reductants. Altogether, our results suggest that different YbbN/CnoX proteins display distinct properties and activities, depending on the presence of the three conserved Cys residues. Graphical Abstract Highlights - CXXC motif is required for the thiol-disulfide reductase activity of YbbN proteins. - XfYbbN and PaYbbN display thiol-disulfide oxidoreductase activity - The affinities of XfTrxR for XfYbbN and XfTsnC (canonical Trx) are comparable - XfYbbN and EcYbbN, but not PaYbbN, display holdase activity induced by hypochlorous acid - Engineering EcYbbN/CnoX by inserting a Cys residue in the SQHC motif resulted in a gain of function (thiol-disulfide oxidoreductase activity) and abolished the HOCl-induced holdase activity.


As technology advances, 3-D ICs can significantly alleviate the interconnect problem coming with the decreasing of feature size and are promising for heterogeneous integration. In 3-D ICs, one of the key challenges is the vertical technology, using through-silicon via (TSV) for different device layers connection. In this paper, by noticing the TSV assignment comes under the influence of the whitespace distribution in a given 3-D floorplan, we proposed an algorithm called whitespace insertion (WSI) based on the floorplan-representation Sequence Pair to make the whitespace distribution in the given floorplan more reasonable for TSV insertion. When given 3-D circuit placement or floorplan results, we also proposed a minimum spanning tree based algorithm for TSV assignment to minimize the total wire length, assuming each net may have at most one TSV on each device layer. Experimental results show that, in the given 3-D floorplans there is a huge gap about 45.54% of the wire length increase between the ideal and the practice. And based on our method, the total wire length can be reduced by 13% on average without changing the chip area.


In this paper, an intelligent control system of car windows and doors based on CAN-bus was introduced. The electrical motor and electronic control module of car windows are connected to the system in the use of serial communication of Distributed Control and Real-time Control supported by the use of CAN-bus. CAN-bus can be used in Data transmission, sharing or inquiry to achieve the purpose of distributed control. Compared with the traditional manual operation or point-topoint interconnection, the use of CAN-bus technology can reduce wiring significantly, as well as a simple body structure. Therefore, system reliability can be improved and easier to maintain. System also has good portability and scalability. This program has certain applied value in intelligent control and userfriendly design of car power windows.


Rich and his co-workers noted that certain anatomic lesions in drug hypersensitivity and in periarteritis experimentally induced by horse serum bear a close resemblance to those of the rheumatic diseases.1This observation led to speculation as to the possible role of hypersensitivity in the causation of rheumatic fever, rheumatoid arthritis, lupus erythematosus and periarteritis nodosa. Therefore, when Hench and his group reported the dramatic effects of cortisone and pituitary adrenocorticotropic hormone (ACTH) in patients with these diseases it seemed possible that the clinical improvement might be due to some change in hypersensitivity induced by these agents. Accordingly, experiments were begun to test the effectiveness of pituitary adrenocorticotropic hormone in patients with diseases clearly due to hypersensitive reactions.2A brief review of our experience with 23 patients with asthma, 5 with serum disease type of reaction to penicillin, 2 with sympathetic ophthalmia and 2 with ophthalmic and skin sensitivity