Objective:To analyze the characteristics of early and late onset severe preeclampsia(S-PE)involving organ damage and its relations with neonatal prognosis.Methods:Eighty mothers with severe preeclampsia and their 80 neonates were divived to two groups according to the onset time of severe preeclampsia:onset ≤34 weeks group and 34 weeks group.The clinical data,pattern of organ damage,complications,and maternal and neonatal outcomes were analyzed.Results:Placenta was the main organ damaged in the early onset group,and the occurrence rate was higher than that in the late onset group(P0.005).Perinatal mortality was much higher in patients with organ damage than in those without organ damage.The early onset group had a poorer outcome than the late onset group.Conclusions:The earlier the onset of S-PE occurred,the severer the pathogenetic condtion is,and poorer the perinatal outcomes will be.Proper treatment and monitoring is essential for mothers with S-PE and the foetus.Pregnancy should be terminated in some of the cases if nessessary.


Treatment of patients with the simultaneous presence of Chiari malformation type I (MC I) and hydrocephalus may include both one-stage and two-stage surgical interventions. The article describes the two-stage surgical treatment experience performed for the first time in the Republic of Tajikistan.   Description of the case. A 50-year-old female patient with a three-year history of bursting headache, dizziness, nausea, and vomiting developed impaired coordination of movements and decreased visual acuity. Computed tomography (CT) revealedsigns of MC I: descent of the cerebellar tonsils 5 mm below the level of the foramen magnum and occlusive triventricular hydrocephalus with symmetrical enlargement of the lateral and third ventricles. The patient underwent surgery – endoscopic third ventriculocisternostomy (ETV) in combination with decompressive suboccipital craniectomy, which was supplemented by CI laminectomy. After the surgery, the symptoms regressed. According to the control CT scan, there was a moderate decrease in the size of the lateral and third ventricles, restoration of the normal anatomical structure of the posterior cranial fossa.


Part 1: Reading Through Intertextuality 1. Intertextuality and the Study of Texts Part 2: Watching with the Simpsons 2. Domesticom Parody, Genre, and Critical Intertextuality 3. Ad Parody and The Logic of Television 4. News Parody and the Public Sphere Part 3: Talking with the Simpsons 5. Parody and/as Interpretive Community 6 'The Simpsons Attitude' Conclusion


THE CEBTP CURVATURE METER WAS DESIGNED FOR HIGH-OUTPUT NON-DESTRUCTIVE TESTING. IT MEASURES THE DEFLECTION AND RADIUS OF CURVATURE OF A PAVEMENT SUBJECTED TO THE LOAD OF A SINGLE TWIN AXLE TRAVELLING AT 18 KM/H. IN THE MODEL THE AXLE LOAD IS 13 TONNES BUT IT CAN BE ALTERED TO ANY VALUE BY MODIFYING THE QUANTITY OF BALLAST ON THE VEHICLE. THE PRINCIPLE OF THE CURVATURE METER IS DESCRIBED TOGETHER WITH THE APPARATUS, RANGE OF MEASUREMENTS, REPRODUCIBILITY OF RESULTS, AND THE CORRELATION BETWEEN MEASUREMENTS WITH THE CURVATURE METER AND THE BENKELMAN BEAM. EXAMPLES OF THE USE OF THE MEASUREMENTS ARE GIVEN.


Based on observed data from the network of long-running ionospheric observation sites, we analyzed the ionospheric effect of D-layer and F-layer about the Eclipse on May 12, 2012 within China. The results indicated that the ionospheric effect is more obvious at middle and low latitudes. The critical frequency of F2-layer(foF2) in QingDao and XinXiang stations is higher than referenced value, and the hight of F2-layer bottom is raised, the observed data (foF2) in GuangZhou station showed obvious photochemical effect, that is "Sunrise delay".


Morphological and anatomical research of saussurea amara is carried out. Significant features of overground part which can be applied as characteristics of herbal authenticity are diagnostically defined. Results of performed research are used for the project of pharmacopoeial article «Saussurea amara».


In histological studies, it has frequently been demonstrated that ultraviolet (UV) exposure, in particular UVB, can induce significant thickening of the viable epidermis and/or stratum corneum. Since skin biopsy alters the original skin morphology and always requires an iatrogenic trauma, we aimed to introduce optical coherence tomography (OCT) in vivo for the investigation of changes of epidermal thickness (ET) following UVA1 and UVB irradiation. Twelve healthy subjects received daily 60 J/cm2 of UVA1 and 1.5 minimal erythema doses UVB on their upper back over 3 consecutive days. Twenty‐four hours after the last irradiation, OCT assessments were performed on UV exposed and adjacent nonirradiated control sites. Data of ET as expressed by comparison of the averaged A‐scans differed significantly between nonirradiated (94.2 ± 15.7 µm), UVA1 (105.4 ± 12.8 µm) and UVB (125.7 ± 22.1 µm) exposed sites. In comparison to the nonirradiated sites, UVA1 exposed skin showed significant (P = 0.022) increase of ET of 11% and UVB exposed sites a significant (P < 0.001) increase of 25%. ET of UVA1 and UVB exposed skin sites differed significantly (P =0.005). Our results obtained from OCT in vivo measurements confirm data of previous histological studies indicating that not only erythemogenic doses of UVB, but also suberythemogenic doses of UVA1 may have a significant impact on ET. OCT appears to be a promising bioengineering technique for photobiological studies. However, further studies are needed to establish its measurement precision and validity, and to investigate in vivo spectral dependence on UV induced skin changes such as skin thickening.


Effort estimation is a key component of planning a software development project. In the past, there has been a lot of research on estimation methods for traditional applications but, unfortunately, these methods do not apply to Extract Transform Load (ETL) projects. Coming up with a systematic effort estimate for ETL projects is a challenging task since ETL development does not follow the traditional Software Development Life Cycle (SDLC). Traditional application development is requirements-driven whereas ETL application development is data-driven. This research paper describes the development of an effort estimation model for ETL projects and compares this model with the most widely used algorithmic effort estimation model i.e. COCOMO II. A dataset comprising 220 industrial projects from five different software houses is used to build this effort estimation model using Forward Stepwise Regression. After eliminating 20 outliers from this dataset, the adjusted R2 (i.e. goodness of fit) of our model is 0.87. The prediction and training accuracy of this model is measured using the de-facto standard accuracy measures such as MMRE and PRED(25). On a training dataset of 200 projects, the training accuracy value of PRED(25) is 81.16% and MMRE is 0.16. Results show that our proposed estimation model provides considerably better estimation accuracy as compared to COCOMO II. On a validation dataset of 58 projects, the value of PRED(25) was 49% for our model as compared to 21% for COCOMO II. Furthermore, the MMRE of our model is 0.31 as compared to 0.99 for COCOMO II.


FOR ALMOST 20 years various pacing devices have been used to prevent or terminate tachycardias. Despite the success of selected applications in wellscreened patients, such devices implanted solely for antitachycardia purposes probably account for less than 1% of all pulse generator implantations.' Availability of alternative therapies, concern that the devices may not work appropriately or may worsen the arrhythmia, and design limitations have restricted the appeal of such therapy. However, the recent development of an implantable defibrillator2 and of a cardioverter3 for patients with ventricular tachyarrhythmias probably will alter this balance in the future. The purpose of this article is to review briefly the available electrical antitachycardia approaches with implanted devices, summarize results, and focus on the need for and type of electrophysiologic evaluation before consideration of such therapy. General. Electrical approaches' can be divided into three broad subheadings: (1) Rate support when symptomatic bradycardia results from therapy for tachycardia, e.g. sinus bradycardia as a side effect of drug administration, or heart block after His bundle ablation. Indications for pacing and the types of devices used in this category can be relatively straightforward, such as using a ventricular demand pacemaker for complete atrioventricular (AV) block, employing dual chamber units that can modulate the ventricular rate during supraventricular tachycardia in the patient with heart block and that also have antitachycardia functions,4 or using rate-responsive units that do not rely on normal sinus nodal function,5 creating another level of sophistication. (2) Prevention of tachycardia onset. These examples include pacing at normal rates to treat complete AV block or other bradyarrhythmias that appear to cause a ventricular tachyarrhythmia,6 pacing to suppress selected tachyarrhythmias such as torsades de pointes,7 pacing at short AV intervals to prevent AV nodal or AV reentrant tachycardias,8 and rapid atrial pacing to initiate an atrial tachyarrhythmia with a high degree of


The embodiment of the invention discloses a data center machine room energy-saving system, which comprises two rows of server machine cabinets placed face to face; the system is characterized in that wind tight baffles are arranged on the upward side and both ends of cold aisles of the two rows of server machine cabinets placed face to face and two ends; the wind tight baffles on the upward side and both ends of the cold aisles, the front of two rows of servers and a floor circle an enclosure space; the floor and/or on the baffles on the upward side of the cold aisles are provided with air outlet receiving cold air coming from an air conditioner and leading into the cold aisles. The system can reduce the energy consumption of the data center machine room conditioner, thus realizing the energy consumption of the data center machine room.


The main aims of the paper are to explore how far class origins and qualifications can account for ethnic minority disadvantage in Britain and to explore whether they operate in the same way for the ethnic minorities as they do for the white majority. Thus the paper examines both the processes that promote inclusion into advantaged positions (in the professional and managerial classes of the salariat) and also the rather different processes that lead to exclusion to unemployment and the disadvantaged and poorly paid jobs of the semi-skilled and unskilled working class. Interest also focuses on entry into the petty bourgeoisie, which has often been used by members of ethnic minorities as a way of escaping from unemployment or low status manual work. The data cover first-generation men, that is men who were born overseas and migrated to Britain. With respect to social inclusion, the results show that class origins and educational qualifications can largely account for the overall disadvantages suffered by Irish men who have migrated to Britain. They also account for about half of the overall Caribbean and Pakistani disadvantage although still leaving substantial disadvantage unaccounted for. With respect to social exclusion, social origins and qualifications account for a much smaller proportion of the overall ethnic disadvantage. Many of these inclusion and exclusion processes work in much the same way for members of ethnic minorities as they do for whites. In particular, contrary to theoretical expectations, advantaged class origins bring the members of ethnic minorities much the same occupational benefits as they bring whites. However, entry to the petty bourgeoisie is a major exception: ethnic minorities are not nearly as successful as the British-born whites in passing on to their sons resources that are helpful for self-employment.


Objective To study the expression of matrilysin in gastric cancer and to evaluate the correlation between its expression and invasion,metastasis,and prognosis. Methods A total of 52 patients with gastric cancer were selected and followed up.The expressions of matrilysin in gastric primary focus,normal gastric mucosa,and metastatic lymph nodes were examined by reverse transcription-polymerase chain reaction(RT-PCR),Western blot,and immunohistochemistry,respectively.The correlations between matrilysin expression and tumor invasion,metastasis,and prognosis were assessed. Results The expressions of matrilysin in gastric primary focus and metastatic lymph nodes significantly increased,while decreased or loss in normal gastric mucosa(P0.001).The higher concordance was seen between the levels of mRNA and protein(P0.001).Among patients with infiltrating type,penetrated serosa,area of serosa involved more than 20 cm2,and metastatic lymph nodes more than 7,the expression of matrilysin was significantly higher(P0.01).The survival rate of patients with matrilysin higher expression(34.1%) was significantly lower than that with matrilysin lower expression(55.6%),χ2=9.778,P=0.002. Conclusions Up-regulated expression of matrilysin plays an important role in tumor invasion,metastasis,and poor prognosis,and it is a good molecular marker to reflect the biological behaviors of gastric cancer.


Ethano-veterinary practices are followed for treatment of different health conditions in India as well as in other parts of the world. Many reports have shown that inclusion of herbs in poultry diet can lead to improved health condition of birds. Several plants are reported to possess immunomodulatory activity. However there is paucity of studies proving molecular mechanism responsible for immunomodulatory potential of plants. Cytokines play crucial role in modulation of immune response. Herbal plants exhibit their therapeutic potential due to the presence of various phytoconstituents that may cause immunomodulation through directly interacting with cytokines. Moringa oleifera (drum stick) of family Moringaceae is one of the well-known medicinal plants. It can act as cardiac stimulants, possess antitumor, immunomodulatory, antipyretic, antiepileptic, anti-inflammatory, antiulcer, antispasmodic properties. Glucosinolates are secondary plant compounds typically found in members of the Brassicaceae and a few other plant families like Moringaceae. Thus the present study was carried out to explore immunomodulatory potential of one of the phytoconstituents glucomoringin of Moringa oleifera Lam. in chicken by conducting in silico interaction studies with six different cytokines of Gallus gallus. The protein sequence of cytokines genes were retrieved from NCBI and 3D structures were predicted through Swiss Model tool. The 3D structure of the phytochemical was retrieved from pubchem. Docking studies were performed by using PatchDock server between glucomoringin and receptors (IL-1β, IL-2, IL-4, IL-5, IL-10 and Interferon gamma) and the results were analyzed. Glucomoringin showed maximum score with IL-1β followed by IL-10. Thus it could be predicted from the in silico analysis conducted that binding of glucomoringin with cytokines may be responsible for its active role for its immunomodulatory potential. However there is a need to further explore its immunomodulatory potential through suitable in vitro and in vivo analyses to confirm these findings.


This paper reviews deep learning applications in medical diagnosis and prediction, such as Convolutional Neural Networks, Fully Convolutional Networks, and Generative Adversarial Networks in medical image analysis. It further summarizes the strength and weaknesses of deep learning in medical imaging and suggests that deep learning's great potential in medical fields.


The cavitation-erosion resistance of carburized 316LN stainless steel was significantly degraded but not destroyed by heat treatment in the temperature range 500-800 C. The heat treatments caused rejection of some carbon from the carburized layer into an amorphous film that formed on each specimen surface. Further, the heat treatments encouraged carbide precipitation and reduced hardness within the carburized layer, but the overall change did not reduce surface hardness fully to the level of untreated material. Heat treatments as short as 10 min at 650 C substantially reduced cavitation-erosion resistance in mercury, while heat treatments at 500 and 800 C were found to be somewhat less detrimental. Overall, the results suggest that modest thermal excursions perhaps the result of a weld made at some distance to the carburized material or a brief stress relief treatment will not render the hardened layer completely ineffective but should be avoided to the greatest extent possible.


The utility model relates to a supporting field, especially a be provided with bluetooth module's subway tunnel lamp of setting up of subway. The utility model discloses an utilization subway tunnel lamp (or advertising?light boxes ) evenly distributed's in subway tunnel characteristics, the ingenious integrates bluetooth module in the lamp, utilizes bluetooth module's the high transmission speed and the characteristic of low energy consumption to realize the information transmission in subway tunnel, because the utility model discloses a bluetooth module have small advantage, can only occupy in the tunnel lamp radio communication function that just realizes the tunnel lamp in very little position, practiced thrift most space and cost, and simultaneously, the utility model provides a with the inconvenient problem of external communication when subway tunnel lamp (or advertising?light boxes ) can effectively be alleviated maintainer and gets into the tunnel and safeguard rail or illumination lamps and lanterns, very big improvement maintainer's work efficiency.


Based on the premise that many teenagers are interested in swimming pools and hot rods, this paper describes some reactions for the identification and application of cyanuric acid.


The present study was conducted to estimate the copy number of mitochondrial sperm cells from Iraqi asthenozoospermic patients by using q PCR. Cases were established of Asthenozoospermia from Kamal AL.Samraee Hospital for Infertility and Baghdad extracts (28 fractions 80 % layers and 28 fractions 40% layers) obtained from 28ejaculates, 16 samples were from asthenozoospermic patients and 12 samples were from control subjects. content of mtDNA 0.05) between non progressive sperm ( copy number of defective sperm fraction and normospermic fractions were 74.2 92.8/copy per cell, respectively. infertile subjects and progressive motile sperms of control percoll layer as well as to non progressive motile sperms of both groups that were separated from 40% Percoll fraction. There is a highly significant difference ( control subject


We discuss the potential of ultrahigh energy (UHE) neutrinos as probe for new particle physics. After briefly reviewing the proposal that the decay products from UHE neutrinos annihilations on relic neutrinos are the observed UHE primaries, we concentrate on the suggestion that UHE neutrinos can acquire cross-sections approaching hadronic size if the string scale is in the TeV range. We review the calculation of the neutrino-nucleon cross-section σNνKK due to the exchange of Kaluza-Klein (KK) excitations of the graviton in a field theoretical framework and discuss the issue of unitarity. Assuming Regge behavior of the neutrino-nucleon interaction mediated by KK gravitons, we find that the effects of large extra dimensions are barely observable.


Limau purut (Citrus hystrix D C ) , cultivated throughout SE Asia, appears to be a selected form of the wild limau hantu (C. macroptera Montr., i.e. C. auraria Michel), though its earliest scientific name may be C. fusca Lour. Complete synonymy with types is presented in a provisional arrangement of 'wild' plants and cultivars. Suggestions for further work on C. hystrix and its relations with other cultivated citrus are made. X Citroncirus is formally reduced to Citrus and a new name proposed for the citrange root-stock, Citrus x insitorum Mabb. A diagram of the relationships through hybridity of cultivated citrus is presented.


The rapid development of cultural industry actuates the transformation of contemporary economy,and in turn the cultural industry's establishment relies on the development of cultural consumption. Therefore,an important internal correlation exists amongst cultural consumption,cultural industry,and the entire economic transformation. The key to achieving the dynamic effect of cultural consumption is to cultivate a cultural consumption market,allocate the key factors of the market with focus on innovation,balance the cooperative relationship between government and market as well as market demand from urban and rural areas,and promote market development through both internationalization and localization.


Abstract.  This article discusses "Derabat" written by Budi Darma using sociology of literature and Genetic Structuralist teories. It focuses on the writer's pont of view in protraiting Indonesian people. The analysis shows that social political condition of Indonesia  in the writer's point of view (Budi Darma) is in a mass. It manifest through the conflicts that emerge among the political etiles and through the decrease of social participant of the "ordinary" class of Indonesian society. Key words: sociology of literature, genetic structurist


The main steam temperature is one of the most important monitored parameters during the operation. This paper uses MATLAB as a visual modeling tool to combine the theoretical study with the realization in engineering. Considering the dominate time delay of the object, cascade and Smith predictor methods are used in system control. Then a satisfactory solution is given based on the comparison between different control tactics. A minor loop is added to overcome the interference before influencing the main parameter, and in the inertial area where the time delay phenomena is serious Smith predictor is used partly to predict the dynamic characters of the process under basic disturbance, so the adjustor takes action in advance to limit the overshoot dramatically. The application of the two methods has good result in the main temperature control.


Cherán is an indigenous town in Mexico that followed a political system established by the Federal Constitution until 2011 when the negligence of the Mexican State to protect the town from organised crime led to a self-defence movement that expelled criminals and overthrew the local government structure. The movement achieved a milestone when the community achieved self-determination through a federal court ruling. The recognition of self-determination was just the beginning of the real challenge to implement a cultural and political project. Fieldwork was conducted in Cherán that utilised ethnographic research and interviews as methods to explore the function of the town's governance. The findings showed that two crucial elements support the Cherán's democracy and exercise of self-determination. First is organised distrust, in which any citizen could serve a watchdog function to exact accountability in the governance structure. This distrust prevents the concentration of power to a few elites and shares power to the citizens. Second is Cheran's identity as an indigenous community, which is not limited to self-identification as a group with a set of values and beliefs, but also a valuable device to keep self-determination alive. Through the combination of three key concepts, namely, self-determination, organised distrust, and identity, this paper offers new insights on an alternative way of sustaining democracy that goes beyond elections.


Space Roles for RobotsRodger A. Cliff, Ph.D.Chief Scientist, Automation and RoboticsLockheed Palo Alto Research Laboratory3251 Hanover St., Palo Alto, CA 94304For the purpose of this paper, I will consider a robot to be a more-or-less automated device which preforms useful physicalwork. Usually a robot performs work which would otherwise have been performed by a human laborer, but robots can alsoperform tasks requiring super-human performance. Robots are especially useful in harsh, dangerous environments where


A catastrophe model of employee withdrawal indicates that declining job performance, absenteeism, and turnover are discontinuous behavioral outcomes of the same withdrawal phenomenon arising from v...


BACKGROUND
We evaluated a transition to retirement intervention that adapted strategies used to support employment of people with intellectual disability in mainstream workplaces. The intervention facilitated their independent participation in mainstream community groups and volunteering.

METHODS
We randomised 29 older Australians who currently/previously worked in mainstream employment into an intervention group or wait-list control group. Hours of independent participation in target activities were collected before and after the 13-week initial intervention/waiting period, and at 52 weeks for intervention participants.

RESULTS
Six of the 12 intervention participants selected an activity and increased hours of independent participation following 13 weeks in the Keeping Active (KA) program and eight were independently accessing their selected activity at 52-week follow-up. None of the 19 wait-list participants increased their independent participation after 13 weeks.

CONCLUSIONS
The intervention was effective and highlighted the need to account for factors such as participant choice in evaluation of individualised programs.


Study Purpose. Poor hamstring muscle flexibility is one of the most common risk factors for hamstring injuries. This is due to tension in the musculotendinus structures which reduces the ability of the muscles to extend rapidly without injury. Therefore, this study aims to prove the effect of using PNF stretching and Static stretching exercises on the level of flexibility of the hamstring muscles in athletes.
Materials and Methods. Researchers used Quasi Experimental Design research procedures. This form of design is a development of true experimental design. After being divided into two, the sample will undergo an exercise program like usually given by the coach and after the practice session cooling down sample will be given two treatments, namely the group with treatment Static stretching And group Which other get treat the PNF Stretching exercise. The subjects of this study were Futsal athletes at SMA Negeri 4 Metro using purposive sampling so that there were 20 athletes. Furthermore, data analysis in this study was assisted using the SPSS 26 application.
Results. The results of the study obtained the results that there was a significant effect on PNF stretching on the level of muscle flexibility of futsal athletes, namely 0.000 < 0.05. The results show an increase in the degree of flexibility of the torso by 19.5%. In Static Stretching, it shows a significant increase in the level of flexibility of the muscles of Futsal athletes, namely 0.000 < 0.05 by showing an increase in the degree of flexibility of the torso by 6.7%. Furthermore, there is no significant difference between PNF stretching and static stretching in increasing the hamstring flexibility of futsal athletes.
Conclusions. The results of this study provide evidence that the PNF Stretching and Static Stretching exercises both have a significant effect on the results of hamstring muscle flexibility. That way, the results of this study can be applied in efforts to prevent injuries in sports. Researchers recommend the application of PNF Stretching and Static Stretching can be done regularly in sports coaching.


—Gujarati language is used for conversation by more than 55 million people worldwide and it is more than 1000 years old language. It is the chief language of the Indian state of Gujarat. There are many dialects of Gujarati like Standard Gujarati, Amdawadi Gujarati, Kathiawadi Gujarati, Kutchi Gujarati etc. The Gujarati language is very rich in morphology like other Indo-Aryan languages like Hindi. Many readability tests are available in the English language, but no readability complexity test is available for the Gujarati idiomatic text. The Complexity score is the sub concept of the readability test. In order to define complexity level of Gujarati text, complexity score of Gujarati text is calculated. We deployed a novel readability complexity score calculation method in which we considered the number of letters of each word, the number of diacritics of each word, Gujarati idiomatic text of n-gram where n=1 to 9, Gujarati idiomatic text of m-meaning idioms where m=1 to 7. The complexity score is calculated as the sum of word complexity score, diacritics complexity score, n-gram complexity score of Gujarati idioms and m-meaning complexity score of Gujarati idioms. We emphasized Gujarati idiomatic text for the calculation of complexity score as idioms make the text more complex to understand. This is an innovative and first of its kind work in the research community of Gujarati language. The results are hopeful enough to employ the suggested complexity score method for developing a readability test method for natural language processing tasks for the Gujarati language.


Clean coal technology for industrial boilers was studied form the aspects of optimization processing and coal classification, technical renovation of industry boiler, and overall SO_2 emission control. Techno-economic analysis shows that, ① energy consumption decreases by 13.45% and countrywide coal conservation is 41 million tons per year, ② SO_2 emission decreases by 80-90% and meets the environmental criterion of 1200mg/Nm~3, ③ Payoff period of this clean coal engineering is less than 4 yeas when the local coal rate exceeds 150RMB/t.Fig 1, tables 5 and refs 6.


【Objective】This study investigated the effects of grafting on heat resistance of different organs of chrysanthemum.【Method】The activities of superoxide dismutase(SOD),peroxidase(POD)and catalase(CAT)in leaves,roots and stems of grafted and cutting seedlings of chrysanthemum were studied at temperature of 40℃.【Result】The SOD,POD,and CAT activities in leaves,roots and stems of grafted chrysanthemum seedlings were significantly higher than that of cutting ones.The average SOD,POD,and CAT activities in leaves,roots and stems increased by 11.6%,378.0%and 260.1%;125.5%,131.3%and 203.1%;and 90.1%,98.0%and 90.5%,respectively.In leaves of grafted seedlings,SOD activity had the largest value of 375U/g.In roots of grafted seedlings,POD activity had the largest value of 605.87U/g.In stems of grafted seedlings,POD activity was slightly higher than the other two.【Conclusion】Grafting is an effective cultivation method to improve the resistance of chrysanthemum to heat stress.The heat resistances of different organs are significantly different.


Background
The aim of the study was to determine a prognostic value of the neutrophil to lymphocyte ratio (NLR), the platelet to lymphocyte ratio (PLR) and the lymphocyte to monocyte ratio (LMR) ratios for survival of patients, operated on due to non-small cell lung cancer (NSCLC).

Methods
The study was conducted on 532 patients, operated on due to NSCLC, in stages IA-IIIA. A total of 174 females and 358 males, aged 36-84 years (the mean age: 63.6 years) were included in the study. The following factors were subject to a statistical analysis, conducted for determination of potential prognostic values of NLR, PLR and LMR ratios: age, sex, nicotinism, the number of leukocytes, neutrophils, monocytes, platelets, histopathological diagnosis, T category, N category, the Charlson comorbidity index (CCI), kind of surgery, patient survival.

Results
The single-factor analysis revealed a relationship between NLR, PLR and LMR values, CCI values, the number of monocytes and the length of survival. The multi-factor analysis confirmed that for patients with expected 2-year survival, PLR above 138 (P=0.0008) is another negative prognostic factor, apart from the stage of the neoplastic disease and CCI above 4. For 5-year survival, such a relationship was not observed.

Conclusions
The PLR ratio is an independent and significant prognostic factor for expected, over 2-year survival of patients operated on due to NSCLC.


In this article the possibilities of functioning of breast as an attractant to male and leading to a long lasting relation in many cases are discussed. The three mechanisms discussed are on the basis of visual stimuli, pheromone and other chemicals like sebum.


OBJECTIVE:To evaluate the clinical efficacy of Xuebijing injection in treating acute paraquat poisoning.METHODS:35 patients with acute severe parquat poisoning who were admitted into ICU of our hospital from Jan.2002 to Apr.2008 were enrolled in our study:15 cases were assigned to control group,20(treatment group)received Xuebijing 100 mL bid for 7~10 d in addition to the therapy as in control group.RESULTS:Liver enzyme and creatinine levels in both group were reduced,with the level in the treatment group significantly lower than in control group(P0.05).The oxygen pressure after one week was significantly higher in treatment group than in control group(P0.05).The mortality was also significantly lower in treatment group than in control group(P0.05).CONCLUSION:Early application of Xuebijing injection can protect major organs from injury induced by parquat and reduce the mortality of parqaut poisoning.


This study aims to determine the ability to write papers by students of physics education courses at the University of KH. A. Wahab Hasbullah. Research subjects were students of physics education at the Faculty of Education, Kh University. A. Wahab Hasbullah in semester 1 of the 2019/2020 school year as many as 30 people. This research uses descriptive quantitative research design because the research objective is to determine the ability to write papers in terms of aspects of the characteristics of the paper, aspects of the structure of the paper and aspects of language use. The data collection techniques by reading the entire paper made by students, the aim is to identify and measure the level of scholarship consisting of the contents of the paper, organization of papers, vocabulary and terms, use of language, and spelling and writing techniques. The conclusion of this study is the ability to write scientific papers (papers) students viewed from aspects of the characteristics of papers by 65% with a fairly good category, the ability to write scientific papers (papers) students viewed from the aspect of the structure of papers by 65% with a fairly good category and ability writing scientific papers (papers) students viewed from the aspect of linguistic use by 63% with quite good category


Abstract
Based on the theory of event coding (TEC), the present paper presents two experiments that explore the possibility whether or not an action effect can become associated with the representation assumed to underlie a familiar movement sequence, that is, a motor chunk. Both experiments used four 4-key sequences, of which two sequences started with the same stimulus, the other two with another stimulus. In addition, each sequence had a specific response tone presented immediately after the first correct response. In the test phase, the tone was either mapped to the same sequences as was practiced, or had been changed to another sequence that started with the same stimulus. Experiment 1 suggested that participants formed a single response and one motor chunk per sequence . Experiment 2 also consisted of four different sequences but had participants perform only two at the same time and confirmed that an action effect can become associated with a motor chunk, although this association is not robust.


Results from 29 semi-mature trials of New Zealand Pinus radiata D.Don indicate that height growth is positively correlated with final-crop stocking in certain circumstances, and where stockings are less than 800 stems/ha (higher stockings were not analysed). A subsidiary dataset, with ages from planting to 7 years, gave results that confirmed these. Twelve of the trials demonstrated a significant (p<0.05) decrease in annual height increment with a reduction in stocking. For these trials there was an average height loss of 0.13 m/year after thinning to final stockings, or approximately 2 m over one typical rotation, for every halving in stocking. One possibility is that this effect is due to wind: lower stockings incur greater wind turbulence, which reduces height growth.


Applications of private matching (PM) are not limited to any specific domain of interest. Social media, e-health and commerce applications can afford to share certain common information without disclosing any extra details. PM ensures to reveal only common information between the communicating parties. In this paper we have presented a light weight protocol named Reflection for PM. Depending upon different requirements of involving parties, Reflection can be used in presence of third party or as a point to point communication. Using services of third party (cloud) where communication has to route through it, it still preserves the privacy aspect of values being matched. The protocol works on a random number and produces the result of matching on behalf of original values, hence it converges in only two pass communication. It also protects any additional slipway of information during or after the PM. It safeguards the user communication against eavesdropper and even from offline attacks. In its simpler version, the protocol can work without using any encryption. Value comparison mechanism in presence of encryption, makes the overall process of PM more secure against hostile users.


Purpose

– The purpose of this paper is to apply an economic sociology perspective to the activity–resource–actor (ARA) interaction model for business relationships. Interaction has been chosen as a conceptual domain where economic sociology has a particularly high potential to advance business-to-business (B2B) marketing in terms of its future research directions.

Design/methodology/approach

– The paper provides a structured account of economic sociology through the description of eight key economic sociology concepts and discussion of the structuration theory. This is followed by an overview of the usage of the eight key economic sociology concepts in current B2B marketing research, and concludes with outlining eight specific future research directions which guide future research on interaction in business relationships.

Findings

– Eight economic sociology concepts are identified: embeddedness, networks, institutions, power, social capital, identity, social structures and cognition. An overview of the application of these constructs within the B2B marketing literature shows how most of them are used as metaphors with a gap in understanding their economic sociology background.

Research limitations/implications

– Future research directions are described individually, do not include potential interaction effects and are developed within the ARA interaction model framework. Given the conceptual nature of the paper, it does not provide any empirical data and illustrations related to any of the eight key economic sociology concepts.

Originality/value

– The paper answers a call for a wider integration of economic sociology into the B2B marketing literature. It provides a systematic eight-concept economic sociology framework to be used by B2B marketing theorists and researchers. The paper finishes with eight concrete future research directions through which an economic sociology perspective can help advance B2B marketing theory and business relationship management practice. A brief discussion of managerial implications is also provided at the end.


West coast of Sumatra is one of the vulnerable areas to natural disaster, such as tsunami. The prevention of potential destruction has to be done in order to reduce victim and economical loss. Naturally, coastal vegetation can reduce the wave strength, hence reducing the destructive force. The aim of this research was to obtain the potential area for greenbelt to support rehabilitation and prevention of potential destruction. Most of coastal area of Sibolga has very low Normalize Difference Vegetation Index (NDVI) value, indicating that area has less vegetation. Field checking showed that the coastal area has dense settlement with less vegetation. Land system found in the coastal area is Kahayan which is suitable for mangrove. The area is alluvium plain, behind the coastal is mountainous and hilly areas. In 100, 200. and 500 meters of greenbelt area width, highest vegetation density was very low, followed by low vegetation class. It means most of the area has no vegetation or less vegetation, therefore Greenbelt planning is needed to protect the beach from potential destruction of natural disaster, mainly tsunami.


In this paper, we propose a segmentation method of color images with being rid of oversegmentation. Many conventional segmentation methods assign one region to each gathering of pixels which have similar property. But, these methods tend to oversegment by the optical influences. Besides, they do not use the edge information, therefore the edge is not always selected to the boundary. In this study, we propose a segmentation method of color images with being rid of oversegmentation. Our method uses not only the pixel's property but also the information of regions' contour. It consists of the first segmentation process and the region combining process. First, the given image is segmented in consideration of the edge information. Next, the obtained regions are combined according to pixels' property and regions' contour.


Consensus exists in mathematics education that classroom assessment is an essential component of effective practice; however, the importance of teacher interpretation of student thinking in the assessment process is often overlooked. The purpose of this interpretative qualitative research study was to examine teachers' interpretations of artifacts of student thinking. In particular, we sought to understand the personal resources teachers used to construct their interpretations. Nine experienced and professionally active teachers participated in two interviews. The first interview was semi-structured and focused on the participants' professional experiences, conceptions of assessment, and assessment practices. The second interview was task-based and involved participants in the interpretation of student artifacts collected from second grade students in the area of place value. The results indicate that teachers applied to the act of interpretation a complex, but personal awareness of student thinking that influenced interpretation, including: (a) conceptions of levels of student performance, (b) expectations for student performance, and (c) awareness of common student difficulties. These results provide support for the conclusion that professional development related to classroom assessment should address the interpretative process of examining student artifacts, with emphasis on developing personal resources used in this process.


Prologue: Aims, Themes, and Motivations.- Prologue: Aims, Themes, and Motivations.- Mathematical Framework: Iterated Relations and Composition.- Dynamics of Relations.- Dynamics of Composed Relations.- Abstract Complexity: Abstraction, Invariance, Attraction.- Abstract Observation of Dynamics.- Invariance, Attraction, Complexity.- Abstract Compositional Analysis of Systems: Dynamics and Computations.- Compositional Analysis of Dynamical Properties.- Case Studies: Compositional Analysis of Dynamics.- Experimental Compositional Analysis of Cellular Automata.- Compositional Analysis of Computational Properties.- Epilogue: Conclusions and Directions for Future Work.


This paper aims at highlighting the fact that "equivalence" represents a concept worth revisiting and detailing upon when tackling the translation process of economic texts both from English into Romanian and from Romanian into English. Far from being exhaustive, our analysis will focus upon the problems arising from the lack of equivalence at the word level. Consequently, relevant examples from the economic field will be provided to account for the following types of non-equivalence at word level: culturespecific concepts; the source language concept is not lexicalised in the target language; the source language word is semantically complex; differences in physical and interpersonal perspective; differences in expressive meaning; differences in form; differences in frequency and purpose of using specific forms and the use of loan words in the source text. Likewise, we shall illustrate a number of translation strategies necessary to deal with the afore-mentioned cases of non-equivalence: translation by a more general word (superordinate); translation by a more neutral/less expressive word; translation by cultural substitution; translation using a loan word or loan word plus explanation; translation by paraphrase using a related word; translation by paraphrase using unrelated words; translation by omission and translation by illustration.


The connection between substance use and crime has attracted attention and study for many years, yet it is still not fully understood. While many studies find a strong correlation between the two, others do not, and the connection is a complex one at best. Politicians and policy makers, however, continue to both pass legislation and campaign around issues surrounding drug use and crime. This study looks at the correlation between the incidence of substance use and violent and income-generating crime among a nationally representative sample of juveniles born between 1980 and 1984. The data used is from the National Longitudinal Survey of Youth 1997. This is the first time that the NLSY97 data has been used to address this question. The study first examines whether juvenile substance use and juvenile crime are, in fact, correlated. It then examines the onset of both behaviors to help determine whether one can be said to cause the other. I find that alcohol, marijuana, and hard drug use are all associated with increases in violent and income-generating crime. Additionally, involvement in both types of crime is also predictive of later substance use. These findings imply a complex relationship between the two behaviors.


The goal of this study is to test the implication of optimal seigniorage theory that in the long run higher tax rates are associated with higher inflation rates and higher nominal interest rates. For this purpose, we examine the long run relationship between nominal interest rates, inflation and tax revenue using time series dataset for Turkish Economy for the period 1980-2011. We estimate the Mankiw's (1987) optimal seigniorage model for Turkish Economy with the cointegration and vector error correction methods (VECM). According to econometric result, in long run there is a causality relationship from inflation and tax revenue to nominal interest rates. However, in short run we could not find any evidence that support a causality from inflation and tax revenue to nominal interest rates.


The transcurrent tectonics in the Djibo area is characterised by sub-meridian sinistral ductile shear zones. The characteristics of the deformation affecting the shear zones in low-grade metamorphic conditions are defined. This major tectonic event is known in throughout West Africa and corresponds to the Eburnean orogeny


The article considers the process of transformation of modern society associated with the development of the digital economy, the main resource of which is digital technology. The author hypothesizes that youth of today (generation Z) is a special social group that can lead the emerging technological changes. Since the new digital biosocial space is a comfortable environment for young people. To prove the hypothesis, the author used the appropriate scientific methodology, including the value-oriented method, that allowed to identify the specifics of value orientations, psychological and cognitive features that characterize youth of today. It is proved that the global processes of Informatization of modern society have formed a number of specific features of the digital generation. It is concluded that it is necessary to create a new model of educational paradigm, which will not only meet the requirements of the digital economy, but will also be able to take into account the specifics of the mentality of young people.


This paper presents a rigorous solution for the half‐space Green's function of the matrix transport equation that describes the flow of polarized radiation in a free‐electron atmosphere. The singular normal modes expansion technique is used to construct the solution in such a manner that the expansion coefficients can be determined by applying the proper boundary conditions. The necessary completeness and orthogonality theorems are proved, and thus all expansion coefficients are found by simply taking scalar products. In addition, the albedo problem for a semi‐infinite half space is solved explicitly.


© BMJ Publishing Group Limited 2023. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION A male patient in his mid50s with a history of arterial hypertension and smoking presented to the emergency department after falling from a height of 1 m. He had a thoracic trauma with fractures of the 1st–6th ribs bilaterally and was discharged with painkillers. Two days later, he was readmitted with an inferior ST elevation myocardial infarction and an acute ischaemic stroke in the territory of the right middle cerebral artery. Given the patient's haemodynamic stability and high likelihood of an embolic aetiology to the clinical condition, it was decided not to perform coronary angiography and stroke treatment was prioritised instead. After endovascular thrombectomy, contrastenhanced CT was performed revealing a mass (18×10×25 mm) in the ascending aortic lumen, without evidence of aortic dissection, aneurysm or tortuosity of the aorta (figure 1). An infarction of the right kidney was also reported. Transoesophageal echocardiography (TEE) confirmed the presence of a pedunculated highly mobile echogenic mass attached to the anterior region of the aortic root, near the right coronary ostium, measuring >15 mm, suggestive of a thrombus. A 12 mm mobile echogenic mass in the anterior region of the left ventricular outflow tract (LVOT) was also identified, suggestive of a thrombus (online supplemental videos 1 and 2). Other findings included left ventricular inferior wall hypokinesia with normal left ventricular function, akinesia of the free wall and diaphragmatic wall of the right ventricle with severe right ventricular dysfunction and small patent foramen ovale with minimal shunt. He was admitted to the intensive care unit where he developed cardiogenic shock with multiorgan dysfunction. Given the high risk of cardiac surgery, a multidisciplinary decision was taken to start anticoagulation with unfractionated heparin after repeating the head CT to exclude haemorrhagic complications. Despite adequate medical management, the patient deteriorated and died after 48 hours. The patient was deemed unsuitable for ventricular support due to his advanced myocardial infarction and significant neurological deficits. Thrombus formation in LVOT and in a nonaneurysmal ascending aorta is extremely rare due to the high blood flow environment. It has potentially lifethreatening complications arising from coronary, cerebral and systemic embolisation. Few cases of aortic mural thrombus have been described in the absence of severe atherosclerosis, aneurysmal disease and aortic dissection. 2 Moreover, cases of LVOT thrombi related to chest trauma have rarely been reported. 4 Diagnostic evaluation of these patients should include a combination of imaging studies, such as TEE and CT. Because there are no clear consensus


Farming practices can have a large impact on the net emission of greenhouse gases, including carbon dioxide (CO2), methane, and nitrous oxide (N2O). The primary sources of N2O from dairy farms are nitrification and denitrification processes in soil, with smaller contributions from manure storage and barn floors. Emissions from all greenhouse gas sources are interrelated, so strategies to reduce emissions from one source can affect emissions from another. Therefore, a comprehensive whole‐farm evaluation is needed, which can be cost‐effectively achieved through computer simulation. The Integrated Farm System Model (IFSM), a process‐based whole‐farm model, was extended to simulate sources of N2O and other greenhouse gas emissions. A module was added to simulate N2O emissions from croplands using relationships from the previously established DAYCENT model, and relationships were incorporated to predict emissions from slurry storage and free‐stall barn floors. The new module was found to predict N2O emissions consistent with reported values from specific experiments and previously estimated whole‐farm emissions. The model also predicted sensitivity to soil texture and soil water content similar to experimental data and DAYCENT model predictions, which further verified this most important component of N2O emissions. Simulations illustrated the impact of management practices on a representative farm in central Pennsylvania. Reducing the use of inorganic fertilizer by accounting for manure nitrogen (N) reduced N2O emission from the farm by 6% and reduced the net farm emission of all greenhouse gases in CO2‐equivalent units by 1%. Adding a mulch cover crop to corn land reduced N2O emission by 34% with a 7% reduction of all greenhouse gases. Use of a top‐loaded manure storage tank prevented formation of a surface crust, which eliminated storage N2O emission with little effect on net farm emission of all greenhouse gases. This extended whole‐farm model provides a tool for evaluating proposed N2O reduction strategies along with their effects on other greenhouse gas emissions, other N and phosphorus losses, and farm profitability.


Introduction Rat-bite fever due to Streptobacillus moniliformis is an uncommon infection, which seems to have been increasingly diagnosed in the Hunter New England–Central Coast area of New South Wales, Australia, in recent years. Method A case series was presented and a review of the literature since 2007 was performed. Results Our case series includes 11 patients with a median age of 27 years (range, 8–61 years), all of whom were diagnosed with bacteremia. All patients reported rat exposure, although only 4 of 11 were bitten. Common features included fever, rash, joint pains, headache, and vomiting. Patients were mostly treated with 2 to 4 weeks of antibiotic therapy; complications were rare with resolution of symptoms at last follow-up in most cases. There have been 87 patients with rat-bite fever described in the literature since 2007. Clinical findings were similar to our case series although complications, particularly endocarditis and septic arthritis, occurred in approximately a third of cases. Conclusions The case series and literature review of rat-bite fever describe a characteristic clinical picture with fever, arthritis, and rash; a history of rat exposure is supportive, and blood cultures with current laboratory techniques are usually diagnostic.


The author introduces K-Gateaux differentiability,K-Frechet differentiability,and goes further into the relationship between K-smoothness and K-Gateaux differentiability,K-strong smoothness and K-Frechet differentiability.


In general, the cause of AntiMA (antimerger acquisition) action is the profitdriven motive, i.e., a defensive behavior required by the stockholders and employees of a business to prevent their own interests from loss. Nowadays, AntiMA taking place in China is also because of the requirement to protect national economic security. Based on an analysis made to the foreign experience of AntiMA strategies and its feasibility if applying it to China at present, a conclusion is drawn that AntiMA process had better come into effect in accord with MA process, in combination with growing awareness of AntiMA, innovated financial system and sound law/regulations required for AntiMA. Some suggestions are offered for solving the current issues found in AntiMA implementation.


The tools of the optical measurement of deformation are increasingly used to characterize the mechanical as well as thermal properties of MEMS or microcomponents. Both, the residual stress state and thermally induced deformation can be analyzed by applying of laser Doppler vibrometry or by several variants of laser based optical methods usually using photoelectric detection. In the paper the application of techniques for the dynamic movement and vibrations measurement of microelements and thin silicon membranes is reported. Using the laser Doppler vibrometry is discussed to evaluate the stress state of membrane-like microbridges, to obtain frequency characteristic and impact response of microcantilever and to measure the resonances of thin silicon membranes. Based on observation of time-averaged light intensity pattern at focal plane, newly developed method of autocollimation is demonstrated with the possibility to visualize the vibration mode shapes of membranes. Beside this, also the experience with laser deflection detecting by position sensitive detector technique is described.


The elements of competitiveness of enterprise culture mainly include learning creativity, administrative creativity and technical creativity. To promote the competitiveness, it is necessary to combine the external and internal competition environments confronting the enterprise, advance the adjustment of enterprise culture to administration, implement the recombination and readjustment among between the internal and external resources, strengthen the management of human resources, and motivate enterprise institutional innovation and inspiring system innovation.


Using a spatial sequence approach instead of a temporal one,plant functional traits and aboveground primary productivity were investigated along successive recovery stages in an alpine meadow on the Qinghai-Tibetan plateau.The functional traits,including plant height,relative growth rate,special leaf area,leaf dry mass content,and total biomass of dominant plant species at the individual and community levels were measured at recovery succession stages of 1,3,7,10,and 15 years.The recovery succession significantly reduced the value of plant functional traits such as plant height,relative growth rate and special leaf area,but increased the value of leaf dry mass content(y=0.170 5x+0.106 3,R2=0.506 5,P0.001).There were negative relationships between plant height(y=-12.299x+410.3,R2=0.678 2,P0.001),relative growth rate(y=-0.022 9x+0.624 7,R2=0.699 2,P0.001),special leaf area(y=-61.171x+2 756.5,R2=0.595 6,P0.001) and succession stage,but a positive relationship between leaf dry mass content(y=0.170 5x+0.106 3,R2=0.506 5,P0.001) and succession stage.A negative relationship also emerged between above-ground net primary productivity(ANPP) and succession stage(y=-0.228x+7.386 7,R2=0.495 4,P0.01).Plant height(y=0.014 7x+0.942 6,R2=0.457 5,P0.01),relative growth rate(y=8.695 4x+1.869 9,R2=0.519 1,P0.001) and special leaf area(y=0.002 4x+0.942 6,R2=0.361 7,P0.01) all had significantly positive effects on ANPP,while leaf dry mass content had no significant effect on ANPP(y=-0.435 5x+6.797,R2=0.101 5,P0.05).The plant height,relative growth rate and special leaf area could be used as predicting traits for ecosystem productivity response to succession in the alpine meadow.In the management and utilization of alpine meadow ecosystems,these three functional traits could be used to describe and predict ecosystem function response to environmental changes.


The International Thermonuclear Experimental Reactor FEAT design for a long-pulse tokamak burning plasma experiment (R=6.2 m, a=2 m, B=5.3 T, I=15 MA) is intended to achieve extended burn in inductively driven deuterium–tritium plasmas with the ratio of fusion power to auxiliary heating power, Q, of at least 10 and a nominal fusion power output of ∼500 MW. It also aims to demonstrate steady-state plasma operation using noninductive current drive with a Q of at least 5. Particular features of the design are: a significant operating window for Q=10 inductive operation; long inductive pulses (several hundred seconds burn); a capability for studying steady-state scenarios, specifically in cases where α-particles make a significant contribution to the plasma pressure; disruption physics processes which are comparable to those expected at the reactor scale; and an α-particle density and heating power which permit the key issues of α-particle confinement and α-particle driven magnetohydrodynamic instabilities to...


The contribution addresses the application of formal methods in functional specification, design and verification of real-time software systems in safety-critical applications. We present basic principles of software verification methods directed towards automatic proof of safety properties against the model of the system. Verification of the railway interlocking system developed by the AZD Prague Ltd. is presented. We discuss advantages and drawbacks of the presented methods and the possibility of using model-checking algorithms in the testing stage of the system development.


This article looks at urban space through the lens of reimagining the status of individuals with disabilities as people with health issues. Today, they are viewed as a social group who claims their right to the city and to barrier-free urban space, and who is characterized by social interaction. The paper argues for an urgent need of creating universal inclusive spaces and specific areas on the city map which would address special needs of individuals with different forms of disability. The results of a survey of individuals with disabilities, residing in the City of Yekaterinburg and Sverdlovsk Region, as well as expert interviews with representatives of local and regional authorities, indicate that the public bodies are aware of the needs of individuals with disabilities and making attempts to address the requests of this group. The respondents identified the following key problem areas: difficulties of moving around the city, a lack of barrier-free access into buildings, and a lack of sanitary facilities in the visited organizations.


Contents of this report include work performed at the University of Wyoming and the University of Colorado. For the University of Wyoming these are: (1) statistical correlations; (2) Hanna core data analysis; and (3) reverse combustion in Balsa Wood. The University of Colorado conducted: (1) reverse combustion studies; (2) water-influx modeling studies and applications; and (3) laboratory core characterization studies.


Financial management defined as behavior and perceptions about how financial is managed. For the present, student financial management refers to the behavior and perceptions of how students manage their finances and handle their money during studies. The aim of this study is to assess university students' financial management skills. Data were collected among Universiti Utara Malaysia (UUM) students. The selection of this sample was students with an age between 18 years old to 25 years old. The sample was selected through the simple random sampling technique with the sample size of 114 respondents. Perceived financial management skills were measured using a Likert scale from 1 (unskilled) to 5 (skilful) on 12 management related items: daily expenses, debt, future needs, time, savings, use of education loan, purpose of education loan, social interaction, stress, decision making, problem solving and career planning. The data were analyzed by using t-tests and Analyses of Variances (ANOVA) through Statistical Packages for Social Sciences (SPSS) version 25. The scores for the financial management skills were computed and the results revealed there was no gender difference in the score. However, the female students showed a higher level of financial skills than the males. Therefore, there are significant differences in the mean score among ethnic groups, with Indian students scoring the lowest compared to other ethnic groups.


LNG which has been very popular as one of eco-friendly energy sources has a clear characteristics in that it is safe and cheap compared with other energy sources. It should be supplied and spread to many people so that they can enjoy this benefit. However, as it is difficult to establish necessary infrastructures due to geographical constraints in the mountain regions and economic feasibility, the polarization of wealth has been much worser over time. Under these circumstances, the study developed a LNG tank container which could complexly be used for land (railway and road) and maritime transportation and as a storage facility to solve this problem. The study established a demonstration project plan for a smooth land transportation of LNG containers and carried out a demonstration project for a land transportation from Pyeongtaek LNG base to Alpensia Resort in Pyeongchang based on a checklist by transportation stage. The study presented the possibility of transporting LNG tank container transportation by land and a revitalization plan.


This study aims to analyze the effectiveness of Work Discipline in Improving the Performance of State Civil Apparatus on the General Bureau of Southeast Sulawesi Regional Sekretariat, with indikators of disciplinary assessment: time discipline, rules and responsibilities and performance appraisal indikators consist of: work achievement, and work performance. This study took a sample of 2 people, consisting of Head of Public Bureau and Head of Administration. The results of research show that the effectiveness of Work Discipline in Improving Performance of State Civil Apparatus At Public Bureau of Regional Sekretariat of Southeast Sulawesi has been done well. This is seen in the indikator of work discipline has the highest score (60.00%) ,, on the level of effectiveness of work indicates that the indikator of achievement of work shows the score (73.33%), so the Effectiveness of Work Discipline in Improving Performance of Civil State Apparatus On Bureau General Sekretariat of Southeast Sulawesi Province can be said to have done well.


Under phosphorus-deficiency stress, changes of abscisic acid (ABA)contents in seedling of three asparagus bean [Vigna unquiculata W. ssp. sesquipedalis (L.) Verd] cultivars differing in tolerance to phosphorus-deficiency were studied. The results showed that ABA contents in root increased under P-deficiency stress, ABA contents declined early, then increased to a peak, and declined again, the peak appeared earlier in cv. Erlubai (Low P-deficiency-tolerance) than cv. Luhuabai (High P-deficiency-tolerance). The increase in cv. Xianggangqingcv. Erlubaicv. Luhuabai. The ABA contents in older leaf, stem and youngest fully-expanded leaf increased under P-deficiency stress, the increase in cv. Xianggangqingcv. Erlubaicv. Luhuabai, but that in cv. Erlubaicv. Xianggangqing cv. Luhuabai at later stage. The ABA contents in younger leaf and stem increased under P-deficiency stress, the increase in cv. Luhuabai cv. Erlubai cv. Xianggangqing. The increase of ABA contents in leaf and stem under P-deficiency stress might enhance transportation of phosphorus and water, reduce membrane lipid peroxidation.


Iron-pyrite (FeS2) has received renewed interest for photovoltaic application due to its high absorption coefficient, abundant supply of constituent elements and expected environment friendliness. In the present investigation, thin-films of iron-pyrite were obtained via sulfurization of sol-gel synthesized hematite (Fe2O3) films at 550 °C and sulfur vapor pressures ranging from 30.4 kPa (0.3atm) to 319.2 kPa (3.15atm). For the studied sulfurization pressure range, each of the iron-pyrite thin-films showed n-type conductivity with charge carrier concentration decreasing by an order of magnitude (10 to 10 cm). The corresponding change in the S/Fe ratio was from 1.81 to 1.99.


The present study reports the length weight relationshipof Olyralongicaudata from Chisang River, Nepal. Study was carried out in 30 fishes collected from April 2019 to Jul 2019. The body weight ranged from 0.8 to 5.2 g and total length from 6.1 to 13.4 cm. Regression analysis was done to analyzed the data. The growth performance of length-weight relationship is found to be highly significant (r=0.936). The fish was found to show isometric growth pattern with exponential value (b) equal to 2.5115.


Motivated by the application of scheduling a sequence of locks along a waterway, we consider a scheduling problem where multiple parallel batching machines are arranged in a sequence and process jobs that travel along this sequence. We investigate the computational complexity of this problem. More specifically, we show that minimizing the sum of completion times is strongly NP-hard, even for two identical machines and when all jobs travel in the same direction. A second NP-hardness result is obtained for a different special case where jobs all travel at an identical speed. Additionally, we introduce a class of so-called synchronized schedules and investigate special cases where the existence of an optimum solution which is synchronized can be guaranteed. Finally, we reinforce the claim that bidirectional travel contributes fundamentally to the computational complexity of this problem by describing a polynomial time procedure for a setting with identical machines and where all jobs travel in the same direction at equal speed.


7. Introduction. THE Raman frequencies of simple molecules have been of great help in the past in verifying the dynamical theory of molecular vibrations and Placzek's polarisability theory of the Raman lines. The complete spectra of these substances often gire valuable clue to the ultimate structure of their molecules. 111 the course of the investigations of the author on the Raman spectra in the field of inorganic chemistry, which has appeared in these Proceedings during the past four years, he has obtained some new unpublished results in the spectra of telluric acid, and of the chromate, molybdate, tungstate, periodate, bisulphate, chlorate, bromate and azide ions as both solids and aqueous solutions. The present paper gives a discussion of these results in relation to the structural properties of these compounds.


The golden rule of Aldo Leopold's land ethic clearly supports active management of predators that harm populations of rare animal species. In the early part of his career, while working as a forester in the American Southwest, Leopold advocated exterminating large predators like gray wolves (Canis lupus lupus) and grizzly bears (Ursus arctos horribilis) from the region, but he later changed his mind when he realized that native predators help maintain ecosystem integrity. Philosophically, Leopold's changing views on predators exemplifies John Dewey's customary and reflective morality. But Leopold's dramatic narrative in A Sand County Almanac about his regret for helping kill a female wolf with pups on the Apache National Forest in 1909 should not be misinterpreted to mean he condemned all predator management as environmentally wrong. On the contrary, today, in some situations, the ecosystem integrity Leopold valued actually may be dependent upon active management of certain predator species. And, in some cases, lethal control may be the best option. I examine situations involving rare species that are harmed by predators in which the land ethic's golden rule (i.e., "A thing is right only when it tends to preserve the integrity, stability, and beauty of the community, and the community includes the soil, waters, fauna and flora, as well as people") mandates predator management. I explain why "letting nature take its course" is not a desirable option, and maintain that, in such cases, the predator management polemic should be focused on how management should proceed rather than on whether it should proceed.


The 21st Century thinking skills are important skills to have for everyone. These skills can be developed through learning and assessment with the help of applications. This study aims to measure 21st century problem solving skills using Seesaw as an assessment for learning. The method used is descriptive. This research was conducted in one class 10 of SMAN X in West Bandung which was selected by purposive sampling. This study used three project based learning projects. The instruments used were tasks, test instruments, and questionnaires. The task is uploaded in the Seesaw application and assessed with a rubric which is modified from the K-12 Public Education standard 2015. The test instrument is adapted from the NAEP (National Assessment of Educational Progress). The results showed that there was an increase in students' problem solving skills with more N-gain scores in the high category. The mastery of problem solving skills was more in mastery. The progress of students' problem-solving skills also increased during the completion of task 1 to task 3.


This paper provides a company survey of the Turkish Aerospace Industry (TAI) which is Turkey's largest defense and aerospace firm. The paper explains and describes the history of the company, its organization and performance. Various statistical indicators of TAI are used to measure competitiveness and efficiency, based on published data at the industry and firm level. The indicators include productivity, output, firm size, development time-scales, job creation, exports and profitability. The study concludes that TAI is developing an air defense company and the firm's productivity is increasing over time, but profitability rates are unstable. Although export level have been increasing their, share in total sales is insignificant and TAI usually meets the domestic demands where their most important customer is the Turkish government.


VHCF crack initiation mechanisms in different engineering alloys Muhammad Waqas Tofique*, Jens Bergstrom*, Christer Burman* *)Karlstad University Department of Engineering and Physics, SE-651 88 Karlstad, Sweden E-mail: email@example.com M.W. Tofique Abstract Fracture in the very high cycle fatigue (VHCF) life regime has drawn a lot of attention during the later years. The fatigue major crack growth makes up for a very small part of the VHCF life, but a large part is spent in initiation and early growth. As this latter will control life length it is of interest to study mechanisms in the initiation and early growth of VHCF cracks. Early work in the field was on pure metals, as on copper, and later the properties of engineering steels were extensively studied. It was found that initiation in steels often occurred at internal defects, e.g. oxide inclusions, and the specific feature of the fracture surface was called optical dark area (ODA), and similar. Now, this initial crack growth zone is often referred to as fine granular area (FGA), describing the very fine rough fracture surface observed around the initial defect. However, other materials may have other distinctive features and it implies different mechanisms. In the present article results from studies on the initiation and early VHCF crack growth in different materials will be discussed. The fatigue crack initiation mechanisms prevalent in high strength martensitic steel grades, hot rolled plate duplex stainless steels, cold rolled strip duplex stainless steel, cold rolled strip martensitic steel and a super alloy grade are compared. The fatigue testing of all the grades was conducted in the VHCF regime using an ultrasonic fatigue testing equipment operating at 20 kHz. The fracture surfaces of failed specimens were analysed using electron microscopy (SEM and TEM). Observations of the fracture surfaces revealed the presence of a microstructure controlled growth of short fatigue cracks in all the tested grades. Fractography of failed specimens of a high strength martensitic steel grade, EN X40CrMoV5-1, revealed the typical FGA within a fish-eye area around the internal inclusions. By mapping the FGA size development during VHCF loading, as obtained from fracture surfaces, FGA growth results were obtained. A similar study on hot rolled plate duplex stainless steel grades, 2304 SRG and LDX 2101, revealed the presence of an initial crystallographic growth region in which crack growth direction is changed by phase and grain boundaries. The early fatigue damage accumulation occurred predominantly in one phase. The fatigue crack initiation in both cold strip duplex and martensitic grades occurred at surface defects due to the cold rolling process of these grades. However, the presence of a FGA zone around the surface crack initiation site was observed similar to the internal initiations in the high strength steels. On the other hand, an initial transcrystalline fatigue crack growth was observed on the fracture surfaces of failed specimens from the superalloy grade Inconel 718. Besides the fracture analysis crack growth data are also presented.


Aim: In this study it has been focused on entrepreneurial university trend which has been very popular especially for a few decades. Entrepreneurial university interlinks its three missions: education, research and serving society. That has meant partly having in a university structure besides traditional education and research functions a technology transfer office (TTO) and active patenting of own research results by the university. That means also creating entrepreneurial competencies and mind set among university members, active position to production and implementation of university knowledge for prosperity of society and entrepreneurial environment inside and around the university supporting knowledge transfer. The concept of entrepreneurial university emerged as a response to a fast changing business environment and to the necessity to delivered graduates more capable to solve more and more complex problems that business face in the era of globalization. Here the target audience of the entrepreneurial university is industry and business world, and the cultivation of qualified manpower to do work in this area is directed to enter the entrepreneurial university of the field. In this study it has been revealed a entrepreneur model that can be applied in universities in the country. The proposed model consists of six themes and their sub-categories. These themes are: evaluation of campus facilities, academic and administrative management, government effect, financing, educational activities, industry cooperation (commercialization) Within the first 50 universities 2014 Index of Entrepreneurial and Innovative University announced by TUBITAK to the public is the population of this study. This index is determined by the method of sampling for 12 university officials and face to face interview was conducted to evaluate the applicability of the model with 12 lecturers having publications in the relevant field. It has been expressed that applicability of proposed third generation (entrepreneurial) university model has been shown to be applicable, but in our country, due to the legal, financial and administrative constraints entrepreneurial university model may not fully be implemented.


A home network device management system and a method thereof are provided to remarkably increase the efficiency of message processing as an HGW(Home Gateway) modifies the header information of an OMA DM(Open Module Alliance Device Management) message only, without the necessity of analyzing and reconfiguring the OMA DM message. A home network device management system, managing a plurality of connected subscriber devices(100-1-100-3), comprises a DMS(Device Management Server)(300) and an HGW(200). The HGW(200) and the subscriber devices respectively comprise OMA DM-based agent modules(210). The DMS(300) manages a plurality of subscriber devices connected with the HGW(200), and executes software upgrading/management and failure management for the subscriber devices. Also the DMS(300) transmits OMA DM messages for subscriber device management, receives associated responses, and manages the subscriber devices. The HGW(200) mediates the data transmission and reception between DMS(300) and subscriber devices, analyzes header information, based on the OMA DM message transmission and reception between DMS(300) and subscriber devices, modifies message header information according to analyzed results, and transmits modified messages to the DMS(300) or associated subscriber devices.


The financial crisis that began in 2007 pointed out deficiencies in policy-makers' responses to systemic risk. It turned out that not only individual bank insolvencies but also spillovers from negative externalities among entities can cause serious threats to the financial sector. During the last 10 years, many international and national initiatives were taken to strengthen the soundness of the financial system, introducing a macroprudential perspective to financial supervision. However, the recent COVID19 pandemic resulted in a serious negative shock for many economies and their financial sectors. In this paper, using the network model we try to analyse how these recent unexpected developments affected the Polish banking sector with systemic risk. To analyse Polish bank stability we developed a formal stress-testing framework based on the network model that allowed systemic risk identification, modelling and measurement. We tried to integrate analysis of time and the cross-sectional nature of systemic risk.


The pectoral nerves (pecs 2) block is widely used as adjunct to general anaesthesia for breast surgery as postoperative pain management. There are a few case reports and a single case series that describe regional anaesthesia as a single technique or supplemented by light to moderate sedation. Regional anesthesia has very few cardiovascular or pulmonary side-effects, as compared with general anesthesia and Pectoral nerve block is a relatively new technique, with fewer complications than other regional anesthesia. Here we describe the management of a 78-year-old lady ASA 3 who presented with a bilateral breasts hyperplasia that is causing her sever back & neck pain, discomfort & recurrent skin infections of the inframammary area. She is type 2 DM, hypertensive and considered unfit for general anaesthesia due to significant ischemic heart disease. A bilateral breast reduction mastopexy was successfully performed under bilateral pecs 2 block and serratus anterior block using a combination of Ropivacaine 0.2% and Levobupivacaine 0.5%


A new series of transition metal complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II), VO(IV), Hg(II) and Cd(II) have been synthesized from the Schiffbase (H 2 L) derived from 4-aminoantipyrine, 3-hydroxy-4-nitrobenzaldehyde and 2-aminophenol. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductance, mass, IR, UV-Vis, 1 H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis, magnetic susceptibility and ESR spectral data of the complexes suggest a square planar geometry around the central metal ion except VO(IV) complex which has square-pyramidal geometry. The redox behavior of copper and vanadyl complexes has been studied by cyclic voltammetry. The minimum inhibitory concentration (MIC) values of the. investigated compounds indicate that the complexes have higher antimicrobial activity than the free ligand. The nuclease activity of the above metal complexes shows that only copper and nickel complexes cleave DNA through redox chemistry.


Control of steel sheet shape and vibration at the air knives can increase the quality, save zinc and reduce costs. In this paper, an electromagnetic actuator set is designed to evaluate the feasibility of using active magnetic levitation technology to control vibration of the steel sheet. Vibration control model is built and incomplete derivative PID controller with series lead compensation is used in this work. Through galvanizing line test, the set can stabilize the sheet motion greatly, improve the galvanizing quality and save zinc.


internationally renowned prisons . . . will help universalize some of the problems facing Le Nuove as a museum/tourist site and to place Le Nuove within a broader global prison museum context' (p. 179). In the last, short chapter, significantly titled 'The Outer Walls', the author examines the perception of Le Nuove 'from the outside', through the relations that the prison institution has had and continues to have with the city of Turin, as well as the role and significance that it may itself have in the future, especially considering that 'certainly its time as a prison has passed and it has entered a new phase of transformation and renewal whose final outcome is still uncertain' (p. 212). At any rate, according to the intentions of the author, the book offers a detailed and well-documented analysis of 'multiple temporalities and meanings brought out through stories in and about the prison' (p. 213). Canright Chiari's work is undoubtedly a very useful testimony and an important scholarly contribution as concerns the 'stories' that have crossed the space of this prison, 'an imaginary mapping of a place as it exists in memory as well as in myth, not as a static place but as an assemblage of events, which are continuously transformed by and for the present' (p. 213). Letme conclude bymentioning that perhaps the author could have investigated in greater depth the historical, political and cultural context that characterized the complex history of the 1960s and 1970s in Italy, so as to avoid dangerous and misleading simplifications of a complex and problematic period that was certainly marked by severe conflicts and social tensions, but also and above all was rich in essential and indispensable political and cultural achievements by antagonistic forces. In addition, she could have lingered longer on the problematic and complex conceptual definition of terms such as, for instance, 'terrorism', 'political violence', 'armed fight' and 'years of lead'. Also, it would have been useful, in my view, had she offered further and more argumentative comparisons with those critical theoretical references (she does, in fact, mention Carlo Ginzburg, Alessandro Portelli, and Foucault) to which the author relates in some ways in the course of her writing. However, perhaps all of this is beyond the intentions and the plans of this challenging work. It is a book that, drawing on the substantial and well-structured archival material and interviews provided to the reader, still remains crucial for anyone who wants to learn in detail and to deepen their knowledge of the 'cultural history' of Le Nuove in Turin.


must have had an Ms chromosome, and the one who supplied the Ns chromosome to the children must have been MsNs. To account for the MS+ child the other parent must have been MSMs. Thus the genotypes of the S-positive children must be MSMs and MSNs respectively. The patient's husband is MsMs, and their son, who is MsNs, got Ms from his father and Ns from his mother. This family does not open up any possibilities of detecting cross overs between the MN and Ss loci, but 123 families have now been investigated without the detection of a crossover (Race, Sanger, Lawler, and Bertinshaw, 1949). This fact and, even more strongly, the maintenance in the general po,pulation of an uneven distribution of S and s with respect to M and N, show that crossovers must be very rare and the linkage between the loci must be comparable in closeness to that between the C, D, and E loci on the Rh chromosome. When it was found that the antibody was probably of spontaneous origin it was thought that its occurrence might be genetically determined. The sera of the patient's three S-negative siblings were therefore examined for anti-S, but none was found.


Organizational communication scholars have paid scant attention to the motivations of people who choose careers in social service organizations. This study examined organizational identification in the context of two Thai social service organizations: government-run Community Development Department (CDD) and non-governmental Population and Community Development Association (PDA). The degree to which CDD members identified with CDD and PDA members identified with PDA was assessed by using the Organizational Identification Questionnaire constructed by George Cheney (1982). Comparison of CDD and PDA scores on Cheney's OIQ provided findings that mirror those of previous studies of organizational identification. Specifically, the level of organizational identification among employees who work for the non-governmental privately-run social-cause organization (PDA) was significantly higher than for employees who work for the government organization (CDD). Thus, the non-governmental organization appears to be more effective than the government organization in fostering employee identification. Interestingly, a factor analysis of Thai responses to the Cheney instrument revealed three dimensions that were different from the three dimensions theorized by Cheney (1982). While Cheney's conceptualization of identification included employees sense of membership, similarity, and loyalty to their organization, the Thai dimensions reflected life values ('pride in membership'), social values ('fit with organization'), and personal values ('comfort zone'). These findings hold important implications for communication scholars who study employee motivation in non-Western organizational contexts.


Definition 1.1 [5] Fix a degree n line bundle ~ on E. Set V = H ~ (E, ~ ) . Identify V| with H~174 Define the shifted diagonal A~:={(x,x+ (n-2)r) lx~E}. Denote by M the set of fixed points for the involution (x, y) ~ (y + 2r, x 2r) on E • E. We say that a divisor D on E • E is allowable if D is stable under this involution, and M occurs in D with even multiplicity. The n-dimensional Sklyanin algebra associated to (E, r) is defined to be the quotient of the tensor algebra,


This study ofhealth seeking behavior outlines the main approaches within the field, and summarizes some of the key findings from recent work around the probes. Health seeking behavior is a somewhat over-utilized and undertheorized tool. Although it remains a valid tool for rapid appraisal of a particular issue at a particular time, it isof little use as it stands to explore the wider relationship between populations and health systems development. If we move the debate into new and more fruitful arenas, this study reaches the conclusion that we need to develop an understanding how populations engage with health systems, beyond health seeking behavior as a tool for describing the determinants ofhealth. This study uses secondary sources and descriptive methodology.


Aims: To determine the relationship between circadian preference and risk for developing alcohol use disorder among medical students and pre-university students. Study Design: An analytical cross sectional study was conducted among non-Muslim Place and Duration of Study: Melaka, Malaysia from September to October 2014. Methodology: 250 participants were selected by using multistage sampling method, 223 students participated (89.2% resposnse rate). Sociodemographical data, assessment of circadian preference by International Journal Chronobiology (IJC) and WHO Alcohol Use Disorder Identification Test were collected using a structured questionnaire. Bivariate analysis, chi-square test, Fisher Exact test and multiple logistic regression analysis were calculated. Results: Out of 223 non-Muslim undergraduate students, 60.09% were having intermediate type, 21.97% were having evening type and 17.94% were having morning type of circadian preference. Only 17.04% of the participants were having moderate, high and addictive alcohol consumption risk; among them 7.9% were addictive and 10.5% were high risk. Participants with evening type of circadian preference were 4.5 times more likely to be associated with a higher risk for developing alcohol use disorder as compared to participants with morning type of circadian preference (OR 4.5, 95% CI 1.2-17.0, P=0.02). After adjusted for age, gender, ethnicity, hostel and monthly allowance, evening type of circadian preference and risk for developing alcohol use disorder were not significantly associated to each other. Conclusion: Circadian preference was significantly associated to the risk for developing alcohol use disorder among the undergraduate and pre-university students in bi-variate analysis without considering other factors such as age, gender, ethnicity and monthly allowance. However, no significant association were found among each of the factors that were being compared. This was because there was a confounding variable which was gender affecting the result. In our study, male students had a higher risk in developing AUD and male students were more likely to have evening type of cicadian preference. We should provide adequate counseling about sleep hygiene, healthy sleep-wake cycle and encourage students to develop morning type of circadian preference in order to reduce the risk of developing alcohol use disorder. risk for developing alcohol use disorder; medical students; pre-university students; cross sectional study.


Purpose: Patients with recurrent incurable, or metastatic (R/M) head and neck cancers (HNCs) refractory to platinum and immunotherapy have poor survival. Cellular therapies have emerged as treatments with potential activity in solid tumors. This proof-of-concept trial investigated an allogeneic cytokine-induced, memory-like (CIML) NK cell infusion followed by IL-15 superagonist (sa) after lead-in CTLA-4 inhibition (ipilimumab) plus lymphodepleting (LD) chemotherapy in advanced HNC. Methods: This phase 1 single-center trial enrolled patients (pts) with R/M HNC (n=7 HNSCC, n=3 salivary cancer) regardless of human papillomavirus (HPV) status who had prior platinum and immunotherapy. Pts in cohort 1 received LD fludarabine (25 mg/m2) and cyclophosphamide (60 mg/m2/kg) on days -6 to -2 prior to haploidentical CIML NK cell infusion on day 0 (5-10 × 106 viable cells/kg=dose level 0) followed by N-803 (IL-15sa, 15 mcg/kg subcutaneously) starting on day +1 every 21-days for 4-doses; in cohort 2, pts received the same regimen with a dose of lead-in ipilimumab on day -7. Cohort 1 treated 3 pts at dose level 0; <2 DLTs triggered an additional 3 pts (n=6). Cohort 2 treated an additional 4 pts. Primary objective: safety, maximum tolerated dose of CIML NK cells. Secondary objectives: objective response rate, progression-free survival (PFS), overall survival (OS), and phenotypic expansion and function of adoptively transferred NK cells. Results: From 9/8/20 to 12/2/22, 10 pts enrolled. One DLT was observed at dose level 0. Median age: 58; 9/10 (90%) were men; 8 (80%) had oropharyngeal primaries (6 HPV+) with a median 6 prior lines of therapy for R/M disease (range: 3-8). Eight (80%) had offspring donors. Grade (G) 3-4 hematologic adverse events were common (10/10, 100%). One patient died of G5 febrile neutropenia and infection (DLT). Median days hospitalized: 15 (range: 9-37). Mild CRS was observed in 6/10 (60%); 5/6 received anti-IL6 therapy; no neurotoxicity was observed. One (10%) partial response (PR) lasted 6.5 months; 6 (60%) had stable disease, 3 (30%) had progression. Tumor regression was observed in 5/10 (50%) at day +30. At a median follow-up of 20.2 mos, median PFS: 2.6 mos (95%CI 1-3.9); median OS: 3.5 mos (95%CI 1-4.7). CIML NK expansion in the peripheral blood (PB) occurred on day +7 in 9/10 of pts. A donor-specific antibody was found in the one patient without expansion. In pts with tumor regression at day +30 compared to those without, CD56dimCD16+ NK cell clusters expanded by day +14 (93.7% vs. 37.3% of PB NK cells). The CD16+KIR+CD57+ NK cell cluster was more prevalent in the ipilimumab-treated pts at the time of tumor regression (16% vs. 4%, p<0.05). Conclusion: Allogeneic CIML NK cells can induce tumor regression associated with persistent CIML NK cell expansion in advanced HNC pts. Tumor regression was associated with CD56dimCD16+ NK cell expansion. We demonstrate safety and feasibility with the expected toxicity of LD. These findings have important implications for the development of cellular therapies in solid tumors.
 Citation Format: Glenn J. Hanna, Roman M. Shapiro, Michal Sheffer, Michela Ansuinelli, Grace Birch, Robert A. Redd, Alejandro Alonso, Denbaa Bat-Erdene, Samantha Himberg, Heather Daley, Diego E. Hernandez-Rodriquez, Katharin L. Shaw, Jerome Ritz, Sarah Nikiforow, Robert J. Soiffer, Rizwan Romee. Allogeneic memory-like natural killer (NK) cell therapy with IL-15 superagonist with or without ipilimumab for advanced, incurable head and neck cancer: A phase 1 trial [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PR11.


(57) Abstract: The present invention relates to a method for treating or preventing arthritis. The method comprises administering an IL-1 inhibitor and methotrexate therapeutically effective amount to a patient in need to treat or prevent arthritis. In a preferred embodiment, IL-1 inhibitor is a recombinant IL-1ra in humans, and methotrexate N-- [4 [(2,4-diamino-6-pteridinyl) methylamino] benzoyl] -L- glutamic acid is there. The present invention also relates to useful in this way, a pharmaceutical composition comprising an IL-1 inhibitor and methotrexate.


A two-fluid, two-dimensional model of the supersonic plasma flow in a divergent magnetic nozzle is extended to include different thermodynamic behaviors for electrons and ions. The effects of electron cooling under a polytropic law are studied, showing that the earlier hypersonic jet associated with cooling results in a lower beam divergence and facilitates plasma detachment. Ion thermal energy is converted to directed kinetic energy by the gasdynamic acceleration mechanism without the mediation of an ambipolar electric field, and alters the electric response of the plasma. Further work to include anisotropic and kinetic effects is outlined.


Vanadium single crystals were irradiated with fast neutrons to 7 x 10/ sup 17/ n/cm/sup 2/ at ca 70 deg C. The critical current density J/sub c decreased with irradiation, the change being ca 4-fold at 1 ROe and 4.2 deg K. DELTA J/sub c/ depends on the temperature and magnetic field. (DLC)