Objective:To investigate the clinical therapeutic effect of modified anorectic powder on anorectic child patients belonging to liver-qi stagnation with spleen-deficiency type.Methods:The study is to apply modified anorectic powder to treat 260 cases of anorectic children of liver-qi stagnation with spleen-deficiency type(82 cases of zinc sulfate control group).After three months of treatment,the clinical effective rate of the modified anorectic powder group is 93.6%,the curing rate 79.3%.body weight equally increases 1.2 kg;The height equally increases potential 2.3 cm;the effective rate of Preventing and controlling recurrent cold is 92.6 %.The curative effect surpasses the control group.After treating 98 cases of zinc lacked in the anorexia children belonging to liver-qi stagnation with spleen-deficiency type,the hair zinc value of the therapeutic group rise to 60.05ppm,the control group increases 39.55ppm equally.Dealt with by statistics,the difference is prominent(P0.001).In testing the urine xylose absorption rate experiment of this type,The 48-cases therapeutic group is higher than the 22-cases control group after the treatment.The group's difference is prominent(P0.05).In the meanwhile,The hemoglobin of the treatment group is obviously higher than the control group,difference of the two groups is prominent(P0.001).Results:The modified anorectic powder can improve the child anorexia of liver-qi stagnation with spleen-deficiency type effectively,make the infant's height and weight increase,also have certain function in improving the absorbing function of small intestine and the content of hemoglobin of the anorectic infants.Conclusion:Modified anorectic powder has good clinical curative effect on the anorectic infants of liver-qi stagnation with spleen-deficiency type.


A laminate of a layered substance, which contains two or more kinds of elements as constituting elements, is added to an ionic liquid containing a specific cation and then the ionic liquid containing the laminate is irradiated with sound waves and/or electric waves.


An important aspect of making good decisions is the ability to adapt to changes in the values of available options. Research suggests that we are poor at changing behavior and adapting our choices successfully. This work contributes to clarifying the role of memory on learning and successful adaptation to changing decision environments. We test the effects of the direction of change and the type of feedback using a decisions from experience binary choice task, where individuals learn the outcomes and their associated probabilities from feedback received after selecting between available choice options. The results revealed a robust effect of the direction of change: risk that becomes more rewarding over time is harder to detect than risk that becomes less rewarding over time; and even with full information about the outcomes of choice options people showed sub-optimal adaptation to change. We rely on three distinct computational models to interpret the role of memory on learning and adaptation. The distributions of individual model parameters were analyzed in relation to participants' ability to successfully adapt to the changing conditions of the various decision environments. Consistent across the three models and two distinct data sets (our experimental data and other researchers' data), results revealed the value of recency as an individual memory component for choice adaptation. Individuals relying more on recent experiences were more successful at adapting to change, regardless of the direction of change. We explain the value and limitations of these findings as well as opportunities for future research.


TPS5094Background: In RCC, the Von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in most cases, resulting in the accumulation and overactivation of HIF-2α. HIF-2α is a key oncogenic driv...


This text discusses the Education in Chemistry worked in High School, from the analysis and reflections of a sequence of classes taught in a school located in Triângulo Mineiro, Brazil. For data collection, we developed open-ended question scripts with five Chemistry teachers from state public schools and we also describe [and analyze] the classes taught by one of the participating teachers. We perceive that the pedagogical practice of the basic education teacher is directed to the preparation of students to succeed in selective processes, in contrast to the practices that aim at training students to Brazilian Journal of Development Braz. J. of Develop., Curitiba, v. 6, n.12, p.103181-103195 dec. 2020. ISSN 2525-8761 103182 effectively exercise their role as citizens in society. Therefore, we reiterate the thesis of scholars when they affirm that high school does not have an end in itself, but distorts the main objective of this educational segment: full citizen preparation.


This paper looks at revenue amounts generated by non-profit hospital foundations throughout the US. A number of inputs, including, among others, compensation, type of support given to the hospital, type of foundation expenditures, and hospital size, were used to develop models of foundation revenue. Both neural network and regression models were developed and compared in order to see which one gave a better model and to see how they ranked the relative value of the input variables. Though the generated value of revenue for both models correlates highly with actual revenue, the neural network shows smaller error. The order of variable importance for the models is very different. Each model would have different implications for foundations in planning their next round of revenue generating events.


As a crude distillation unit(CDU) is one of the important processes in refinery industries and consumes enormous energy, an optimal design of a CDU was attempted. The target CDU is under commercially operated and its capacity is 150,000 BPSD. The mathematical models for an atmospheric distillation column(ADC) and naphtha stabilizer were established and we formulated the objective function so as to minimize the energy consumption. The optimal feed locations of both the atmo- spheric distillation column and stabilizer were obtained by solving mixed-integer nonlinear programming problems. The opti- mal duties of condenser and pumparound in the ADC were determined by the optimization task. In the case of optimal design, vapor and liquid load was apparently decreased and the size of the ADC and the stabilizer was accordingly decreased. The opti- mal feed tray of ADC and stabilizer were 34 and 14 respectively, and the condenser duty of the ADC was decreased by the amount of 15% and the duty of pumparound, which permits heat recovery, was increased by the degree of 37%.


With the rapid development of the unmanned aerial vehicle (UAV) industry and artificial intelligence industry, UAV has been used in the civil field. For civil UAVs, the distribution of logistics UAV is a hot research topic. Based on the UAV data set, the value function model of logistics UAV task planning is established by deep learning. It is found that there are obvious differences in value function for different deep learning methods. Moreover, it is also found that using the Random Forest Model has a good effect on the modeling of the value function. On this basis, the task planning model of logistics UAVs based on K-Means is established. In order to find an optimization algorithm suitable for the logistics system, this research uses an improved Genetic Algorithm, improved TS Algorithm, and Particle Swarm Optimization Algorithm to solve the model. By comparing three intelligent optimization algorithms, it is found that the improved TS Algorithm not only converges faster for this model but also has fast convergence for a large number of logistics task points by comparing the flight route and convergence curve of the objective function, which can meet the needs of largescale tasks in the actual logistics system.


A satellite communication anti-jamming design combing direct sequence spread spectrum(DSSS) and adaptive nulling antenna is proposed.For different jamming conditions and satellite transponding modes,theoretical analysis of system anti-jamming performance is given.It is concluded that the system anti-jamming capability can be effectivly improved by combining DSSS and adaptive nulling antenna and then performing onboard regeneration processing and transponding.


The article discusses the results of a study on the use of probiotic preparation "Monosporin" and of phytobiotic feed additive "Intebio" in the feeding of suckling calves, and their complex application. The results of the study showed that inclusion of the probiotic "Monosporin" and the phytobiotic "Intebio", both separately and together, in the calf diet had a positive effect on their increase in live weight and the resistance formation of the experimental livestock, which affected the low incidence of young cattle. The best results were noted with the combined use of the preparations "Monosporin" and "Intebio" at the end of the experiment, young animals from group 4 were superior to analogs from other groups in all studied parameters. Based on the studies carried out and the experimental data obtained, it can be concluded that the complex use of the probiotic preparation "Monosporin" and the phytobiotic feed additive "Intebio" in the feeding of young cattle according to the proposed scheme has a positive effect on an increase in live weight and growth gain, as well as the formation of immunity and the resistance of the organism of young cattle.


Purpose – The purpose of this paper is to study the effects of temperature, dissolved oxygen (DO) and velocity of seawater on corrosion behavior of three copper‐based alloys (admiralty brass, aluminum brass and Cu‐5Ni alloy used in condenser tubes).Design/methodology/approach – A series of electrochemical tests were carried out in seawater at different temperatures and DO contents using both stationary and rotating‐disc electrodes in order to investigate the corrosion behavior of alloys under these conditions.Findings – It was found that admiralty brass exhibited a significantly higher corrosion rate and Cu‐5Ni alloy was more resistant to corrosion than were the brasses. With increasing temperature, the corrosion rates of the brasses increased. Selective zinc dissolution took place over the whole temperature range. Increasing temperature decreased the corrosion rate of Cu‐5Ni alloy in seawater due to formation of a passive film. The passivation of the alloy could be explained by the presence of greater pr...


Nowadays, most weather forecasting centers produce ensemble forecasts. Ensemble forecasts provide information about probability distribution of the weather variables. They give a more complete description of the atmosphere than a unique run of the meteorological model. However, they may suffer from bias and under/over dispersion errors that need to be corrected. These distribution errors may depend on weather regimes. In this paper, we propose various extensions of the Gaussian mixture model and its associated inference tools for ensemble data sets. The proposed models are then used to identify clusters which correspond to different types of distribution errors. Finally, a standard calibration method known as Non homogeneous Gaussian Regression (NGR) is applied cluster by cluster in order to correct ensemble forecast distributions. It is shown that the proposed methodology is effective, interpretable and easy to use. The clustering algorithms are illustrated on simulated and real data. The calibration method is applied to real data of temperature and wind medium range forecast for 3 stations in France.


Objective: This current study was conducted to evaluate clinical, radiographic, and functional data, as well as complications associated with the repair of medial meniscus posterior root tears (MMPRT) using pullout sutures technique. Materials & Methods: the current study started in January 2014 till June 2016, including 27 patients with MMPRT who underwent arthroscopic pullout suture repair surgery. Of these, 25 patients were analyzed, clinical results by using Lysholm score and international knee documentation committee (IKDC) and magnetic imaging resonance (MRI) were evaluated, as a preoperative state as well as at the last follow-up visit. Results: Improving mean value of Lysholm score in all patients from the poor score in 15 patients as well as a fair score in 10 patients preoperatively to good score in 19 patients and an excellent score in 6 patients the last follow-up visit. IKDC men value become much better it changed from 43.36 ±5.35 preoperatively to 81.89 ± 8.48 at the final follow-up (P ˂ 0.001).


Different media are used to report news happening all around the world to the public. The news from all over the world is a big data source on the Internet. Besides, the news media have their own writing style and stands towards the news which may cause great influence towards readers' opinion. It is valuable to analyze the insights of various media. The existing works on sentiment analysis for the news data do not have a user-friendly interface to present their work and the news data are not retrieved regularly for continuous data analysis. To address the above problems, we propose Cat's Eye Project which aims to identify the stands of different news media through the usage of the words of those media, forecast the trend of some social issues, find out whether there is any indication before a new social issue formed and present our findings by using a user-friendly interface. We build our system on Google Cloud and use the built-in machine learning algorithms on Google Cloud to develop our learning model. By using cloud technology, the system implementation period is highly reduced, and it also guarantees the scalability of our system. The output finding can be used as interesting insights. Our pilot study showed that the media can affect the readers' opinion towards social issues.


A 74‐year‐old man was found to have a paralysed left hemidiaphragm within four months of the appearance of a typical herpes zoster rash involving his left shoulder and neck. Investigations, including bron‐choscopy and computed tomography of the chest, failed to detect a cause for the diaphragmatic paralysis. We believe that the cervical zoster and diaphragmatic paralysis were causally related, a rare but recognised association.


What the plantibody says ?
Iam a portmanteau derived from a plant and an antibody endo membrane and secretory systems- clinically viable proteins Pathogen resistance.


An improved Gaussian mixture particle filter algorithm is proposed for the highly non-linear bearing-only tracking system where the common tracking filters often fail to catch and keep tracking of the emitter.In the algorithm,based on the characteristics of SPKF and particle filter,the limited Gaussian mixture model is used to approximate the posterior density of states,system noise and measurement noise.The greedy EM is used to obtain the reduced order model and overcome such disadvantages of the standard EM as the number of the mixture components is assumed a known a priori,the performance of the overall parameter estimation process depends on the given good initial settings,and the estimated parameter can be resulted from some local optimum points,thus lessening effects caused by sampling depletion.Simulation results show that the algorithm outperforms the one based on PF and the one based on EM-GMPF in tracking accuracy and stability.Therefore it is more suitable to the nonlinear state estimation.


Thin organic coatings or monolayers on semiconductor and metallic substrates are straightforward to detect by FTIR spectroscopy, using either ATR methods or grazing angle specular reflectance. It is much more difficult to detect such coatings on plastics, because the refractive indices of the two materials are so closely matched. However, detecting these films on plastics, such as polycarbonates, is becoming increasingly important as the industry continues to expand. Polycarbonates and other plastics are widely used as an alternative for glass in products such as optical lenses, medical devices and electronics equipment. Plastics offer many advantages. They are lighter than glass and do not shatter, in addition to being easy to color, mold and recycle. However, polycarbonates and other plastics weather poorly, scratch easily and are permeable to some gases. To circumvent these limitations, polycarbonate and plastic substrates frequently are coated. These coatings include anti-reflection, antiabrasion and chemically resistant films. Some of these coatings are extremely thin and not readily detected by standard ATR spectroscopy methods. This paper explores the use of high incident-angle Ge-ATR to detect these thin coatings on polycarbonates and other plastic substrates.


Background: A 19 base pair deletion in dihydrofolate reductase (DHFR), an enzyme that reduces folic acid to tetrahydrofolate, has been implicated to play a role in folate related health outcomes.


The Fast Flux Test Facility (FFTF) is a 400-megawatt (thermal) sodium-cooled reactor designed for irradiation testing of fuels, materials and components for LMRs. It is operated by the Westinghouse Hanford Company for the US Department of Energy on the government-owned Hanford reservation near Richland, Washington. The first 100-day operating cycle began in April 1982 and the eighth operating cycle was completed in July 1986. Argon is used as the cover gas for all sodium systems at the plant. A program for cover gas monitoring has been in effect since the start of sodium fill in 1978. The argon is supplied to the FFTF by a liquid argon Dewar System and used without further purification.


Aiming at the shortcomings of sparrow search algorithm, such as dependence on initial solution, sudden drop of population diversity in the late iteration period, and easy to fall into local optimal value, a multi-strategy algorithm was proposed to improve sparrow search algorithm. In the initialization stage of the algorithm, the standard Brownian motion is introduced to enhance the global search ability of the algorithm and improve the population diversity. In the later stage of the algorithm iteration, the improved artificial bee colony search strategy is introduced to accelerate the convergence of the algorithm, and the influence of local extreme points on SSA can be reduced to improve the ability of the algorithm to jump out of the local optimal solution. The experimental results show that the improved sparrow search algorithm has faster global convergence speed, better optimization accuracy and stability in function optimization.


Objective To assess and compare the sensitivity, specificity, and predictive values of human epididymis factor 4 (HE4) and CA125 (cancer antigen 125 or carbohydrate antigen 125) in the evaluation of ovarian masses (whether benign, endometriomas, or malignant). Patients and methods This was a prospective study carried out in Kasr Al Aini University Hospitals that included 30 patients who presented with adnexal masses and were treated surgically. Patients were divided into three groups: patients with benign ovarian masses, those with ovarian endometriomas, and those with malignant ovarian masses. Assessment of history, examination, and laboratory workup including HE4 and CA125 were carried out for all patients, in addition to abdominal and vaginal ultrasounds, surgical treatment, or staging. Results An receiver-operator characteristic curve with area under the curve in benign versus malignant ovarian lesions showed a 100% sensitivity and a 96% specificity for CA125 at a cut-off value of 40, whereas it showed a 100% sensitivity and a 67% specificity for HE4 at a cut-off value of 42.7. Conclusion In our study population, measurement of HE4 did not provide further benefit over measurement of CA125 in patients with ovarian masses (whether benign ovarian cysts, endometriomas, or malignant ovarian diseases). As the sample size of our study is small, further studies are needed to confirm or confute this result.


The timing sequence curves and spatial isolines of gravity are drawn,and the dynamic variation and its characteristics of gravity anomalies before Wenan M5.1earthquake that occurred on Jul.4,2006 are analyzed.The results show that the process of seismogeny is relevcmt to the variation of gravity field;the epicenter usually locates near 0 isoline of high grads region.


We studied the clinical effects of high-dose methotrexate(HD-MTX)combined with rituximab and vincristine in 5 elderly patients, aged 65-83 years, with diffuse large B-cell lymphoma of the central nervous system(DLBCL CNS). Patients aged 65- 71 years were given 3.0 g/m2 of HD-MTX, while patients aged 75-83 years were given 1.5 g/m2 of the drug. All patients showed responses; 1 CR and 1 PR in MTX 3.0 g/m2 group, and 2 CRs and 1 PR in MTX 1.5 g/m2 group.


This paper presents a modeling and an analysis of one-dimensional periodic structure composed of a cascade connection of N cells considered as infinite. The ABCD matrix representations with the Floquet analysis have been used to derive the dispersion relation and input impedance of infinite periodic structure. The transmission matrix for the N identical cascaded cells has been successfully used to obtain an efficient and easy-to-use formula giving the necessary number of cells such that they can be considered infinite. As an illustrative example, the formula is applied and verified to finite size TL periodically loaded with obstacles. Scattering parameters and the input impedance of the structure are expressed and plotted.


Manganese oxide minerals are a significant component of the fracture lining mineralogy at Yucca Mountain (Carlos et al., 1993) and within the tuff-confining unit at Yucca Flat (Prothro, 1998), Pahute Mesa (Drellack et al., 1997), and other locations at the Nevada Test Site (NTS). Radionuclide sorption to manganese oxide minerals was not included in recent Lawrence Livermore National Laboratory (LLNL) hydrologic source term (HST) models which attempt to predict the migration behavior of radionuclides away from underground nuclear tests. However, experiments performed for the Yucca Mountain Program suggest that these minerals may control much of the retardation of certain radionuclides, particularly Np and Pu (Triay et al., 1991; Duff et al., 1999). As a result, recent HST model results may significantly overpredict radionuclide transport away from underground nuclear tests. The sorption model used in HST calculations performed at LLNL includes sorption to iron oxide, calcite, zeolite, smectite, and mica minerals (Zavarin and Bruton 2004a; 2004b). For the majority of radiologic source term (RST) radionuclides, we believe that this accounts for the dominant sorption processes controlling transport. However, for the case of Np, sorption is rather weak to all but the iron and manganese oxides (Figure 1). Thus, we can expect to significantly reduce predicted Np transport by accounting for Np sorption to manganese oxides. Similarly, Pu has been shown to be predominantly associated with manganese oxides in Yucca Mountain fractured tuffs (Duff et al., 1999). Recent results on colloid-facilitated Pu transport (Kersting and Reimus, 2003) also suggest that manganese oxide coatings on fracture surfaces may compete with colloids for Pu, thus reducing the effects of colloid-facilitated Pu transport (Figure 1b). The available data suggest that it is important to incorporate Np and Pu sorption to manganese oxides in reactive transport models. However, few data are available for inclusion in our model. A survey of published data found only single-point (Triay et al., 1991; Kersting and Reimus, 2003; Keeney-Kennicutt and Morse, 1984; 1985) and qualitative (Duff et al., 1999; Dyer et al., 2000a; 2000b) Np and Pu sorption information. This report describes recent experiments that quantified the sorption and desorption of Np(V) and Pu(IV) onto three manganese oxide minerals as a function of pH and time. The three manganese oxides (pyrolusite, birnessite, and hollandite) have all been observed on fracture surfaces at Yucca Mountain and are likely to predominate at the NTS. Pyrolusite, birnessite, and hollandite comprise both a range of manganese oxide structure (framework, layered, and tunnel, respectively) and composition and a range of observed manganese oxide mineralogies. The pH range of 3-10 used in these experiments covers the range of pH observed in NTS groundwater (Rose et al., 1997).


Multifrequency testing by a microcomputer uses discrete interval periodic muitifrequency test signals to interrogate a system with the aim of system identification in a non-parametric frequency response form. It involves one multifrequent experiment which combines the traditional monofrequent experiments. Data measurement, which is the precision measurement analogy of data communication, allows identification coding theorems and symbolic operations to be successfully applied in the design of a variety of data measurement signals. The three main symbolic operations are symbolic coding, symbolic phase shift keying and symbolic addition. In certain kinds of experiments the most suitable multifrequency test signal should be adapted so that the signalto-noise-power-ratio at the output is the same for each test frequency. Commonly the noise at the system output has a uniform power spectral density. This paper examines the use of weighted symbolic addition of square waves in the design of multifrequency adaptive digital test signals for this situation. These precision test signals have complementary multisymbol codes determined by the DAC output levels.


We obtain the minimum bandwidth required to meet an outage constraint in a multi-tier heterogeneous network assuming "maximum (biased) average received signal power" as the tier association metric. To do so, we model user and access point (AP) locations as Poisson point processes, and obtain the moment generating function (MGF) of the required spectrum; this analysis, in turn, is based on the cumulative distribution function of the bandwidth required by a typical user. Using this user load and the distribution of the coverage area of a typical AP, we derive the MGF of the AP load. We consider path loss attenuation and Rayleigh fading on both the desired and interfering signals; however, the expression for the AP load can be generalized to include arbitrarily distributed fading. An application of the results is to relate the AP outage rate and the tiers' allocated bandwidths.


A selective, rapid thermal-cyclic atomic-level etching (ALE) of tungsten is developed. The first step of this process is exposing the surface of tungsten with hydrofluorocarbon plasma at −22°C to form a tungsten fluoride-based surface modified layer on the tungsten surface. The second step is rapid thermal annealing with infrared (IR) irradiation to remove the surface modified layer. Tungsten 4f peaks and a fluorine 1s peak, which were assigned to tungsten fluoride, were observed by in-situ x-ray photoelectron spectroscopy immediately after plasma exposure. The peaks that originated from tungsten fluoride disappeared after the samples were annealed. Cyclic etching tests were carried out by repeating plasma exposure and IR irradiation with a 300-mm ALE tool. Films of tungsten, TiN, and SiO2 were used as sample materials. The amount of etched tungsten increased as the number of cycle repetitions increased. The etched amount per cycle for tungsten was 0.8 nm. In comparison, etching of TiN and SiO2 was not detected. Conformal etching profiles of patterned samples after 60 cycles were obtained. Furthermore, the etched amount per cycle showed saturation behavior with regard to plasma exposure time. Selective, rapid thermal cyclic ALE of tungsten was thus successfully demonstrated.


Abstract : An empirical system was developed for local application to permit both the assessment of relative conflagration potential (by assigning ratings to urban blocks indicating their relative susceptibility to mass fire) and the delineation of firebreaks to isolate or divide conflagration areas. The basis of the system was the application of fire protection engineering principles to evolve formulae and relative ratings for the factors involved in fire spread. Results consistent with the observations of experienced fire department officers were achieved when assigning numerical ratings to predominant factors; then applying a generalized formula for computing block ratings to indicate relative conflagration hazard. However, to obtain actual exposure distances required individual analysis of structures along the potential firebreak. As a result, two analytic methods were prepared, and simplified versions of each were devised. The regular and simplified methods were field tested by civil defense and fire department volumteers to insure ease of application, conformity to existing knowledge of fire spread, and consistency of results. The final versions are considered valid for the purposes set forth. (Author)


Background: Neonatal dermatoses by definition encompass the spectrum of cutaneous disorders that arise during the 1st 4 weeks of life. The appreciation of normal phenomena and their differentiation from the more significant cutaneous disorders of the newborn is critical for the dermatologists and pediatricians. Aims and Objectives: The aim of the study is to estimate the prevalence of various neonatal dermatoses and identify varying patterns of various physiological and pathological dermatoses. Materials and Methods: This was a hospital-based, cross-sectional study conducted during a period of 6 months. A total of 150 neonates were examined and data were collected, and results were analyzed statistically. Results: Out of 150 neonates, 147 (98%) had cutaneous lesions. Among them, 79 (52.6%) were male and rest were female. Of these, 112 (74.6%) weighed between 2.5 and 4 kg, 35 (23.3%) <2.5 kg, and 3 (2%) >4 kg. Physiological skin lesions were most common features seen in 148 (98.6%), followed by birthmarks 46 (31.3%), transient noninfectious lesions 35 (23.3%), inflammatory eruptions 13 (8.6%), and infections 7 (4.6%). Conclusions: A good knowledge of neonatal dermatoses is necessary for the treating dermatologists and pediatricians as many of cutaneous conditions are transient, appearing in the 1st few days to weeks of life, only to disappear shortly thereafter. However, their occurrence makes the parents worrisome. Proper diagnosis of the conditions helps in relieving the anxiety of parents and caregivers.


Underwater gas-tight structures will generate radiated noise when gas leaks, the identification of the radiation noise can be used to detect the presence of leaks in underwater structures and to remedy them at an early stage. The generation of gas leakage radiation noise is a very complex nonlinear process, so it is more difficult to make an accurate description and identification of it. An experimental environment is designed for the identification of gas leakage radiation noise from underwater structures, and a support vector machine identification method based on higher-order spectral features is proposed. Firstly, by extracting the higher-order spectrum of the signal, the signal features are made more prominent, thus improving the classification accuracy of the target recognition algorithm, and then the signal is classified based on the support vector machine to identify the gas leakage. The research results show that the method can effectively classify and identify simulated leakage targets, and has good prospects for engineering applications.


Introduction After the end of stable economic growth in many important industries, effective management of declining industries has become a relevant topic both for management practitioners as well as researchers (Harrigan 1988, Welge/Huttemann 1993). For instance in Germany, according to the industry classification of the German Federal Statistics Office, one finds that six manufacturing industry clusters representing more than 10% of net production reported a shrinking index of net production for at least ten years (1986-1996). These industries were (1) mining, (2) textile production and clothing, (3) leather manufacturing and processing, (4) iron production, (5) the foundry industry, and (6) aerospace, ship, and rail manufacturing (Statistisches Bundesamt 1997). Many reasons exist for industry-wide decline (Hartigan 1988). In summary, such reasons include location quality, regulatory changes, entry of new competitors, characteristics of a national economy, the business cycle, technical obsolescence of products or processes, sociological or demographic change, and changes in consumer requirements. Despite the relevance of understanding decline, few recent studies provide empirically-substantiated insights into successfully managing companies in shrinking industries. Traditionally, investigations of management patterns in declining industries focus on isolated functional management aspects, such as marketing procedures or product management (Sarfert 1989), restructuring (Targetti 1991), and divestiture (Bruggerhoff 1992). Other authors elaborate on relationships between industry decline and corporate life cycle theory (Miller/Friesen 1984), portfolio theory and business unit strategies (Trummer 1990). Few studies have analyzed companies in declining industries in a more holistic manner, i.e., included a broader range of variables which account for intra-industry variance of company success measures (Hartigan 1988, Vasconcellos/Hambrick 1989, Welge/Huttemann 1993). Given this overall situation, the purpose of the present study is to provide empirical data on levels and determinants of business success in one specific declining industry. This approach has two distinct advantages: (1) industry specific measures of success and of managerial practices can be tailored to meet the particular measurement requirements of the chosen industry which, in turn, contributes toward a study's contents validity; (2) the approach captures industry specific tendencies and, therefore can disentangle determinants of success which hold in particular for industries sharing similar structural characteristics (e.g., decline of demand, predominance of mid-size firms). We chose to analyze the German iron, malleable cast, and steel foundry industry. Four main reasons let to the selection of this industry: First, demand indicators clearly revealed that firms in the foundry industry operate under conditions of severe decline. Second, the German foundry industry included approximately 400 firms at the end of 1992. Thus, the number of firms in this industry is large enough to justify the expectation that one could reach a sample size in a mail survey sufficient for the use of multivariate statistical methods. Third, no previous research has explored empirically efficiency determinants in the foundry industry. Fourth, normative results obtained for the foundry industry may also hold for a number of similar supplier industries dominated by mid-size firms.(1) In addition to the substantial purpose given above, a further methodological objective of our work is to demonstrate the usefulness of an advanced OR-method, Data Envelopment Analysis, in the context of analyzing key success factors. This method can provide industry specific success criteria by capturing technical and revenue efficiency of foundries. Background: Modified Chance-Risk Profile of the Foundry Industry In Germany, the market for foundry products has decreased since the 1980s. …


This study presents a novel approach for building change detection from digital surface models (DSMs), which are generated from the images acquired by a multi-line digital airborne sensor ADS40. Our approach is based on building extraction, which is one of the most challenging research fields. A scheme is proposed that allows efficient integration of a local surface normal angle transform (LSNAT) method and a marker controlled watershed segmentation (MCWS) method for building extraction in dense urban areas mainly from DSMs, and subsequently, performs change detection based on the results of building extraction and the height difference of DSMs. The merits are that really changed buildings are detected, and false-detection can be decreased considerably compared to some other change detection methods. The proposed approach presents wonderful results for building extraction and acceptable results for change detection. * Corresponding author.


Periprosthetic infection (PJI) is a disastrous complication after artificial joint replacement. In the treatment of PJI, early and timely diagnosis of PJI and identification of pathogenic microorganisms are still the keys to successful treatment. However, there are still many shortcomings in the existing bacterial culture technology. Next-generation sequencing technology has been gradually applied to the diagnosis of PJI due to its characteristics of rapid, accurate and comprehensive diagnosis of pathogenic microorganisms. But, most of the current clinical joint surgeons are still lack of understanding of the next-generation sequencing technology and its application in the diagnosis of PJI. This paper reviewed this issue.

Key words:
Joint Prosthesis; Arthroplasty; Infection; Diagnosis


Patterns of preference for 12 labels of styles of music were examined, and the effects of gender, age, and training investigated. Subjects responded by indicating their preference on a 10-point Likert scale, and information on gender, training, and age was collected. Analysis of variance of data revealed significant main effects for training and style. In addition, the style by training, style by age, and the 3-way interaction of training, age, and style were all significant. Results broadly support findings in the literature regarding the effects of age and training on preference; however, the lack of effect of gender does not correspond to past literature regarding the prominence of gender influences.


The Riverside Police Department conducted a DUI/Driver's License Checkpoint on Friday, May 27, 2011, as part of Riverside's commitment to public safety. This checkpoint was one of many that have been or will be conducted throughout the year in the city of Riverside. The location of Friday's checkpoint was on Adams Street at Briarwood Drive. The goal of the DUI Checkpoint was removing impaired drivers and to bring awareness to the public of the dangers of driving under the influence of drugs and alcohol.


Polyamide molding material [5.10] containing A) 40 to 90% by weight of polyamide [5,10]; B) 10 to 60% by weight of fillers containing fibers or minerals, and C) 0 to 20% by weight of further additives, wherein the sum of the percentages by weight of components A) to C) gives 100% result.


On the basis of original gray forecast model,through re-building background value,the paper optimizes GM(1,1) forecast model.The test proves that the optimized model accuracy is higher than original model accuracy,which has great reliability and applicability.


The work of this thesis is aimed to the preliminary beneficiation potential evaluation and testing carried out on samples collected in a new zinc-lead ore deposit, currently under exploration, in the Gorno Zinc Project, Lombardy, Italy. The first part of the work focuses on a global overview on zinc and lead as commodities, highlighting their geological features, reserves and resources, exploitation and processing methods, industrial and economic importance. The second part describes the Gorno Mining district, its geological setting, industrial history, the present situation of the site and future developments planned by the owning company Alta Zinc Ltd. The experimental part introduces the materials and methods used for sampling, characterization and testing of the samples. Thin sections characterization has been carried out by Optical Microscopy and Scanning Electron Microscopy. Comminution tests have been conducted to understand the crushing behaviour of the material, while target minerals' grades have been estimated by means of XRD Quantitative Phase Analysis. Concentration potential has been assessed by froth flotation, arranged in two phases bulk flotation phases divided in two circuits. Final concentrates have been characterized by means of Optical macroscopic observation and XRD analyses. Recovery separation rates have been estimated.


BACKGROUND
Thyroid cancer is the most common malignancy of the endocrine system, accounting for ~ 5% of all thyroid nodules and 1% of all systemic malignancies. BRAF mutations, primarily p.V600E hot spot mutations, are found in 60 - 70% of papillary thyroid cancer cases (PTC) and in 33 - 40% of fatal anaplastic thyroid cancers (ATC), also called poorly differentiated thyroid cancer. Dabrafenib was approved by the United States Food and Drug Administration (FDA) in 2018 to be applied in combination with trametinib for unresectable advanced or metastatic anaplastic thyroid cancer harboring the BRAFV600E mutation. Unfortunately, there are few reports on the pathophysiology, molecular mechanism, and risk factors of interstitial lung disease induced by combined BRAF- and MEK-targeted therapy.

CASE PRESENTATION
We treated a 73-year-old man with metastatic BRAFV600E-mutated poorly differentiated thyroid cancer using the combination of dabrafenib and trametinib. Although a significant morphologic tumor response was observed in our patient using combined BRAF- and MEK-targeted therapy, he presented with non-febrile respiratory failure, and his chest computed tomography (CT) revealed bilateral reticulation and pleural effusion. Withdrawal from dabrafenib-trametinib and administration of methylprednisolone rapidly improved his respiratory status and imaging features.

CONCLUSION
The mechanisms of lung disease after the combined treatment with dabrafenib and trametinib are unclear. We hypothesized that dual-targeted therapy with a BRAF inhibitor, dabrafenib, and a MEK inhibitor, trametinib, might prevent the regeneration and proliferation of fibrotic epithelium in lung disease by blocking downstream proliferative signals.


Actinomycetes are filamentous Gram-positive bacteria that potential sources of antimicrobial substances. The aim of this study was to isolate actinomycetes from different soil types in Enggano Island and screened their antimicrobial activity. The phenol method with 802 medium and humic acid vitamin (HVA) medium was used to isolate the actinomycetes. Furthermore, molecular identifications were performed based on 16s rRNA gene sequence. Antimicrobial activity screening was performed against Bacillus subtilis BTCC B.612, Escherichia coli BTCC B.612, Micrococcus luteus BTCC B.552, Staphylococcus aureus BTCC B.611, and Candida albicans BTCC Y.33 by using the agar plug diffusion method. Fifty-six actinomycetes isolates were obtained from 11 soil types. Most of the isolates were Streptomyces genus with species S. hydrogenans, S. coelicolor, and S. koyangensis, which have similarities in the 16S rRNA gene sequence ranging from 98 -100%. Among isolates screened for their antimicrobial activity, five isolates, i.e. SMP 6, SMP 7b, SMP 18, SHP 9-3, and SHP 22-1a showed a potential activity against test microorganisms selected. All of isolates were more active against C. albicans compared with the tested bacteria. Further study will be conducted to isolate active substances against C. albicans.


Background: Based on numerous reports citing high sensitivity and specificity of non-invasive imaging [e.g. computed tomography angiography (CTA) or magnetic resonance angiography (MRA)] in the detection of intracranial aneurysms, it has become increasingly difficult to justify the role of conventional angiography [digital subtraction angiography (DSA)] for diagnostic purposes. The current literature, however, largely fails to demonstrate the practical application of these technologies within the context of a "real-world" neurosurgical practice. We sought to determine the proportion of patients for whom the additional information gleaned from 3D rotational DSA (3DRA) led to a change in treatment. Methods: We analyzed the medical records of the last 361 consecutive patients referred to a neurosurgeon at our institution for evaluation of "possible intracranial aneurysm" or subarachnoid hemorrhage (SAH). Only those who underwent non-invasive vascular imaging within 3 months prior to DSA were included in the study. For asymptomatic patients without a history of SAH, aneurysms less than 5 mm were followed conservatively. Treatment was advocated for patients with unruptured, non-cavernous aneurysms measuring 5 mm or larger and for any non-cavernous aneurysm in the setting of acute SAH. Results: For those who underwent CTA or MRA, the treatment plan was changed in 17/90 (18.9%) and 22/73 (30.1%), respectively, based on subsequent information gleaned from DSA. Several reasons exist for the change in the treatment plan, including size and location discrepancies (e.g. cavernous versus supraclinoid), or detection of a benign vascular variant rather than a true aneurysm. Conclusions: In a "real-world" analysis of intracranial aneurysms, DSA continues to play an important role in determining the optimal management strategy.


If moments of singular measures are passed as inputs to the entropy maximization procedure, the optimization algorithm might not terminate. The framework developed in our previous paper demonstrated how input moments of measures, on a broad range of domains, can be conditioned to ensure convergence of the entropy maximization. Here we numerically illustrate the developed framework on simplest possible examples: measures with one-dimensional, bounded supports. Three examples of measures are used to numerically compare approximations obtained through entropy maximization with and without the conditioning step.


Objective To study the mechanism in which the personality, copying style influenced survival time by changing immunity function in the patients with gastric cancer Methods The Minnesota Multiphase Personality Inventory (MMPI), coping style questionnaires (CSQ) and immunity function were measured in patients with gastric cancer on late stage (groupⅠ), gastric cancer patients with longer survival time (groupⅡ), and normal control Results Psychopathic deviate, social introversion subscale scores of MMPI in groupⅡ were significantly lower than that in the other two groups ( P 0 05) Statistical difference were found between groupⅠand groupⅡ in problem saving factor (SP) and help seeking factor of CSQ ( P 0 05) Natural killer cell (NKC) level in groupⅡ was significantly higher than in groupⅠ( P 0 05) There was negative correlation between the NKC and depression, psychopathic deviate, paranoia, psychasthenia, schizophrenia subscale scores of MMPI, there was positive correlation between NKC and SP, coping type in patients with gastric cancer Conclusion The gastric cancer patients with longer survival time are more extroversive and have more mature coping styles Their NKC level is relatively higher The results may be advantageous to improve the prognosis of gastric cancer


Resumen en: As the biological cycle of mussels (Mytilus galloprovincialis) is widely known, we try to verify whether the aliphatic hydrocarbon levels in the free-li...


Aim To investigate the principles of diagnosis and treatment of early postoperative inflammatory small intestinal obstruction.Methods The clinical features and treatments of 32 patients with EPISIO were analysed.Resalts Allcases were cured in the mean period of 19 days through nonoperative therapy.Conclusion Non-operative treatment is satisfactory for early postoperative inflammatory small intestinal obstruction,it well worth further recommending and applying.


Human eye movement is a key concept in the field of vision science. It has already been established that human eye movement responds to external stimuli. Hence, investigating the reaction of the human eye movement to various types of external stimuli is important in this field. There have been many researches on human eye movement that were previously done, but this is the first study to show a relation between the complex structure of human eye movement and the complex structure of static visual stimulus. Fractal theory was implemented and we showed that the fractal dynamics of the human eye movement is related to the fractal structure of visual target as stimulus. The outcome of this research provides new platforms to scientists to further investigate on the relation between eye movement and other applied stimuli.


In this paper, a printed monopole array antenna is designed, which is suitable for omnidirectional coverage above conductive carrier. The printed monopole is used as the radiation unit to construct a four unit linear array, and a more stable pattern coverage is realized in the horizontal plane perpendicular to the array axis. The monopole radiator adopts the combination of trapezoidal structure and rectangular structure, and the gradual microstrip line is used to feed it. In order to improve the stability of the pattern, a compact microstrip feed network is designed to ensure the in-phase radiation of each unit. The whole antenna array is realized on a printed circuit, which has simple structure and easy processing. A printed monopole antenna structure operating at 0.5GHz is designed. The electromagnetic simulation results show that in the frequency range of 0.47GHz and 0.55GHz, the voltage standing wave ratio of the printed monopole array antenna is less than 2, the gain is about 3.1dBi and 2.6dBi respectively, and the gain at the center frequency point of 0.5GHz is about 3.7dBi. In the horizontal plane, the rise of the pattern is less than 2.5dB relative to the mean value. The test results of the actual machined antenna show that the monopole subarray antenna proposed in this paper is feasible.


Mice immunized with the red cells of sheep (6.6×107/g body weight) were sacrified to collect sera and spleen samples in order to investigate the influence of light inversion on primary as well as secondary immune responses, and changes in the course of time of the immune response was studied. Tests for hemagglutination (HA) and hemolytic reaction (HR) were carried out to find the antibody titers in the sera, and the numbers of plaque-forming cells (PFC) in the spleen were counted. The following results were obtained: 1) The loss of immune response was significant in mice immunized on the 4th day after inversion of the light-dark cycles with the dark period prolonged, as compared with the control group under an unchanged light-dark regimen. 2) On prolonging the light period, similar phenomena were observed. 3) The time for the immune response on the 4th day after the inversion of light-dark cycles indicated that antibody production was suppressed only in the initial phase of the immune response.


The balanced development of provincial compulsory education refers to the balanced condition between all kinds of conditions and facilities that education needs and education investment.Based on this,the high quality and balanced development of the compulsory education can be realised.Thus,the equality of education rights can be fulfilled within regions,cities and universities.Faced with obstacles limiting the development of provincial compulsory education including economic elements,policies,systems and management,we have noticed that there are countermeasures promoting provincial compulsory educaiton as follows: 1.We should make sure the responsibilities that government at all levels should take.2.We should establish the scientific financial transfering system.3.We should standardise the secondary education development and push it into balanced development.4.A standardised teacher's salary system should be establised.5.We should establish a long-term and effective system for exchanging teaching staff and enhance countryside teachers' in-service training to achieve the balanced allocation of teaching staff.6.We should speed up the development of nine-year secondary school education through eduaction resources to improve countryside education quality.7.We should also speed up the development of education information technology to enhance the balanced development of compulsory education.8.Supervision and evaluation should be enhanced as well in order to establish the monitoring system of the balanced education development.


Visual search is a common task both in naturalistic settings and in the laboratory. Outside the labora tory, one might look for a car in a parking lot, a name in text, or a nav igation marker on the horizon. In the laboratory, search is simplified in several ways; commonly, the sub ject views a set of distinct objects and is asked to detect the presence of a particular object (the target) among a set of distractors. Two ex amples are shown in Figure 1. The top two panels illustrate the contrast increment task, in which the target is a disk of high luminance and the dis tractors are disks of lower lumi nance; the bottom two panels illus trate the line bisection task, in which the target is a rotated L and the dis tractors are rotated Ts. One of the most studied aspects of visual search is the effect on per formance of the number of objects, here referred to as the display set size. Display set sizes of 2 and 24 are illustrated in Figure 1. In the top panels, the target "pops out"?even for a large display set size. More pre cisely, display set size has little or no effect on search time or accuracy when the target is much brighter than the distractors. In contrast, in the bottom panels, finding the target requires "scrutiny" for the large set size. Display set size has a large ef feet on both search time and accu


Once again the concept of populism is en vogue, partly due to the fact that leaders such as Chavez in Venezuela and Berlusconi in Italy have come to power. However, the Social Sciences have serious problems in defining populism and elaborating a political theory to grasp this phenomenon. The present article attempts to fill this void. It is divided into two sections. The first part presents a historical analysis of the concept of populism, which demonstrates that it has been used to tackle a set of ambivalences immanent to all political order. The second part elaborates an ideal-typical definition of populism and offers a theoretical outline of this phenomenon. The proposed theory transcends the demonisation or divinisation of populism; it offers a perspective that helps to comprehend rather than pass a normative judgment on the concept.


This Special Analysis (SA) develops revised radionuclide inventory limits for trench disposal of low-level radioactive waste in the presence of wood products in the E-Area Low-Level Waste Facility. These limits should be used to modify the Waste Acceptance Criteria (WAC) for trench disposal. Because the work on which this SA is based employed data from tests using 100 percent wood products, the 40 percent limitation on wood products for trench (i.e., slit or engineered trench) disposal is not needed in the modified WAC.


In the present application, optimally injecting various fuel into the combustion chamber, embodiments of the configured injection apparatus so as to ignite is disclosed. Injection device according to one embodiment, an end portion configured to be placed adjacent to the combustion chamber, carried by an end portion, and an ignition function portion configured to generate an ignition event including. Injector also includes a force generating assembly and the movable valve. Force generating assembly, and the second force generating device including another first force generating device. The first force generating device generates a driving force to move the valve between the open position to the closed position and the combustion chamber. The second force generating device is electrically connected to the ignition function unit for ignition function unit supplies a voltage for generating at least partly ignited event.


Background : The prevalence of hyperlipidemia in Indonesia is increasing from year to year, in 2008 it was recorded at 35.1%. Then in 2013 it increased to 35.9%(WHO, 2013). Increased hyperlipidemia triggers Non-Alcoholic Fatty Liver Disease (NAFLD)(Ghanaei et al., 2019). NAFLD conditions cause liver cell damage, causing increased levels of liver enzymes such as SGOT and SGPT (Prahastuti et al., 2020). According to Pradana et al. (2017) it is said that red spinach leaf extract has antioxidant activity that is able to inhibit the incision of the oxidation chain reaction because it contains flavonoid compounds, quercetin, tannins, and saponins which have the potential as a preventive therapy for fatty liver. Objective: To determine the effect of red spinach (Amaranthus tricolor L.) leaf extract on SGOT and SGPT levels in white rats (Rattus norvegicus) fed a high-fat diet. Research Methods: The research method uses a literature study. The database in the literature study was obtained from Google Scholar, PubMed and NCBI which was taken by Population, Intervention, Comparation, Output, Study, and Time (PICOST) from 5,166 journals and finally 8 journals were obtained. Results: Literature from 8 journals is known to have 8 that discuss red spinach leaf extract. Conclusion: From the literature obtained, there was an effect of giving red spinach leaf extract (Amaranthus tricolor L.) on the levels of SGOT and SGPT given a high-fat diet. The dose is 200mg/kgBB and 400mg/kgBB with a duration of administration of 7 to 29 days. Keyword : High fat diet, Red Spinach Extract, Hyperlipidemia, NAFLD, SGOT, SGPT, White Rat


with biventricular failure and multiple-systemic organ compromise. The development of post-implantation acute respiratory failure with profound hypoxic lung injury has previously been reported. Veno-venous (VV) as well as VA ECMO has been successfully used in case studies as a suitable strategy to enable adequate oxygenation whilst allowing time for recovery of lung function. We have reviewed our experience. Methods: Single-centre, case series review of patients who required VV ECMO in conjunction with the TAH (Syncardia, USA). Results: The underlying etiology of cardiac dysfunction included: dilated cardiomyopathy; myocarditis; biventricular failure postvalvular surgical intervention, and biventricular failure following ascending aortic dissection repair. 4 patients were bridged to TAH on VA ECMO, with average treatment duration of 6 days; all these patients were intubated. Prior to ECMO cannulation, the average FiO2:PaO2 ratio was 56 (49–73.9) associated with a significant deterioration in respiratory mechanics with increased plateau inspiratory pressures (28-36cmH2O), and reduction in tidal volumes (217-400cc) and lung compliance. All of the patients had bilateral pulmonary infiltrates on chest radiographs. In four patients VV ECMO support was initiated prior to leaving theatre and in the other after 11 hours on ITU. In all cases the indication was refractory and severe hypoxemia. One patient had a Protek Duo cannula (Cardiac Assist, Pittsburgh, PA, USA), the others had two-cannula configurations. ECMO support was weaned off successfully in 4 patients after significant improvement in respiratory function, with an average treatment duration of 152h. One patient developed multi-organ failure and both TAH and VV ECMO support was withdrawn. Conclusions: The mechanism of this acute lung injury would appear to have multiple contributing factors including pre-existing lung injury, pulmonary edema secondary to mechanical obstruction of venous return during chest closure, and reperfusion lung injury. Additionally, pre-implantation VA ECMO support may mask pre-existing lung pathology. There were no additional operative factors or prolonged cardiopulmonary bypass times that may suggest a reason for deterioration in lung function. We describe our experience after TAH implantation and how VV ECMO was successfully weaned off in 4 out of 5 patient with resolution of the acute lung pathology. CCMCritical Care MedicineCrit Care Med0090-3493Lippincott Williams & WilkinsHagerstown, MDCCM


In 1977 the U.N. Commission on Human Right recommended to ECOSOC a request to the U.N. Secreta1ry-Gen ral to undertake a study, in connection with debates initiated in UNESCO, of the intemational dimen sions of the right to development as ai human right. On the basis of the Secretary-General's study of 1979, the Commission on Human Rights adopted a resolution in that year stating that the right to development was a human right and "as much a prerrogative of nations a of indi idua1s within nations." Two years later, in H)81, ECOSOC approved the Com rnission's decision to establish a Working Group of 15 gcwernm ntnl ex perts to dwell upon the matter; from 1982 to 19 5, the Working Group mbarked on the elaboration of a draft Dec:laration on th Right to Devel opment, considering its ".individual" and "coll ctive" asp cts. In 1985 the matter wa referred to the U. . Geneml Assembly, where for two years it was the object of dense negotiations. In 1986, th m Committee of the Gen eral Assembly adopted the Declaration by 133 votes in favour, one again t, and 9 abstentions, th U.N. Declaratlon on the Right to Development was 8


In the following, bypassing dynamical systems tools, we propose a simple means of computing the box dimension of the graph of the classical Weierstrass function defined, for any real number~$x$, by\[{\mathcal W}(x)= \sum_{n=0}^{+\infty} \lambda^n\,\cos \left ( 2\, \pi\,N_b^n\,x \right),\]where $\lambda$ and $N_b$ are two real numbers such that $0 <\lambda<1$, $N_b\,\in\,\N$ and $\lambda\,N_b >1$, using a sequence a graphs that approximate the studied one.


Reports from the committee members and others follow in abstract. Names and addresses of contributors are given as references for readers. The Chairman has complete reports on file.

Some studies are stressing techniques and reliability of the infiltrometer. A study is being initiated using the double ring technique on a number of soils ranging in texture from coarse sands to clays (H. R. Haise and Neil Dimick, Fort Collins, Colo., Agricultural Research Service and Angostura Project, S. Dak., respectively). It is planned to use about 20 double ring infiltrometers at each site and to sample the soil thoroughly within each infiltrometer ring for subsequent physical analysis. It is hoped to isolate some of the physical factors affecting infiltration. Attempts will be made to determine the number of samples needed to account for soil variability. Another study is now underway in Eastern Oregon to determine the reliability of the double ring infiltrometer for estimating field intake rates under different methods of irrigation (F. M. Tileston, Agricultural Research Service, Ontario, Ore.).


Objective Pulmonary ventilation/perfusion(V/Q)imaging was used in the diagnosis of atypical suhsegmental pulmonary embolism(PE)and monitoring the response to anti-coagulation.Meth- ods A total of 141 patients(58 men,83 women,40~83 years)underwent ~(99)Tc~m-MAA and ~(99)Tc~m-Tech- negas pulmonary V/Q imaging,and then underwent pulmonary perfusion imaing after 1-24 months oral an- ticoagulative therapy.Fourteen cases had lower limbs venous lesions,45 diabetes mellitus or hyperlipaemia, and 63 the history of invasive diagnosis or therapy management recently.Pre-and post-anticoagulation ima- ges were compared and combined with clinical information and other imaging modalities to assess the subseg- mental PE.Results All pulmonary perfusion images showed defects in different sizes with normal pulmo- nary ventilation images.After therapy,the radioactive uptake and distribution in both lungs improved in 118/141(83.69%)eases.The post-treatment scans were judged normal in 35 patients,obviously improved in 49,mildly improved in 34.Conclusion Pulmonary V/Q imaging provided accurate information in both diagnosis and post-therapy monitoring of atypical subsegmental PE.


We show there is evidence that a method of summing important logarithmic corrections which are significant in the large-x region leads to a superior description of deep-inelastic scattering data (analyzed using the evolution equations). Next-to-leading-order calculations can imitate the impact of this summation method, but at high x it appears that there are higher-order and higher-twist corrections which separate those approaches.


lishment supporting the armed forces. The seaman has always appeared the victim of corrupt administration. Debt, wastage, apparently excessive contractprices and allegations of inefficiency on the part of state officials all aspects of current concerns with state policy now featuring prominently in debates in the House of Commons were just as prominent, ifnot more so, in the eighteenth century. Now, as then, it is easy to blame individuals for their wayward ways, to condemn entire departments on account ofthe failings of a few individuals, and to blame the managers of limited staff for neglecting work low on their priority list. Both books therefore present popular views of the naval establishment. Could the Victualling Board have been both wise and incompetent? The conclusions ofthese two books are really incompatible unless one realizes that corporate policy evolved, embodied in the experience of long-established commissioners and clerks. The managers are the focus of these books; the clerks figure not at all except as miscreants in Macdonald's book. Among both clerks and commissioners, there were undoubtedly men who became ill, old and less efficient as they passed the age at which people normally now retire. But commissioners and clerks worked together to ensure contracts and supplies met demands. They learned from mistakes. They filled loop-holes in contracts. They supported faithful and conscientious contractors who encountered difficulties. They dropped the devious and unreliable ones. At the same time, the Victualling Board was not isolated either physically or governmentally. Its office was crammed into Somerset Place alongside other Admiralty and Treasury offices and it was part of a state establishment steadily being moulded to meet the demands of public opinion. Views at the time were thus changing. Apparent wisdom and incompetence existed side by side, facets ofthe same bureaucracy. Moreover, just as the bureaucracy and its tasks were developing, so too were the ideas and standards by which decisions and competence were judged. It was therefore the greater corporate consciousness which determined state achievements and reforms and it is to the ideology and expectations embodied in that consciousness to which these two books lead. Consequently, Macdonald, Knight and Wilcox have performed a service over and above the particular purposes their books perform. Important contributions in their own right, their books fill gaps in knowledge about the organization of British naval power. At the same time, their books form steps to a greater understanding of the British state. Authors and publisher are to be commended. They contribute to a new understanding ofthe nation and its achievements to which the supply offood to its armed forces was fundamental.


A. D. Mekhtiyev, e-mail: email@example.com, S. Seifullin Kazakh Agro Technical University, Nur-Sultan, Kazakhstan. P. A. Kropachev, S. Zh. Aizhambayeva, A. А. Kalinin, Karaganda Technical University, Karaganda, Kazakhstan. R. Zh. Aimagambetova, Republic State Enterprise on the right of economical jurisdiction "Kazakhstan Institute of Standardization and Metrology", Nur-Sultan, Kazakhstan. A. D. Mekhtiyev, National Research Tomsk Polytechnic University, Tomsk, Russia. Y. Zh. Sarsikeyev, S.Seifullin Kazakh Agro Technical University, NurSultan, Kazakhstan Th e article presents the results of computer simulation related to establishing the parameters of mine hoisting machine steel structure strengthening elements. The simulation was performed using the ANSYS computer program. The basis of this program is the finite element method therefore, selecting the type and the size of the finite element affects the calculation accuracy. There have been studied 11 computer models. The results obtained make it possible to establish the strengthening element optimal shape, size and thickness. The most optimal shape of the pad is a disc; this has a positive effect on reducing the level of mechanical stresses in the fracture zone of the beam. The strengthening element «disc pad» is used to combat fatigue failure of the brake beam structures of a mine hoisting machine. The article presents practical experience in the fight against fatigue failure of f mine hoisting machine steel structures.


OSP liability: Paris Court of appeal confirms the abandon by French Courts of the "notice and stay down" doctrine* In a decision of 21 June 2013, the Paris Court of Appeal has confirmed that the…


This report summarizes test work performed on the Flakt-Boliden absorption/steam stripping flue gas desulfurization (FGD) process for the Electric Power Research Institute (EPRI). The Flakt-Boliden process employs a sodium citrate buffer solution to remove sulfur dioxide (SO/sub 2/) from gas. The scrubbing solution is regenerated by stripping with steam. The basic process was tested in a pilot plant of about 1 MW scale at Tennessee Vally Authority's (TVA) Colbert Power Plant. This report discusses the results of those tests. 8 figs., 13 tabs.


The collection and examination of student data, encompassing academic achievements, awards, and certifications, assume an essential function within the field of education as a means of showing students' capabilities. Nevertheless, it is crucial to note that regular paper-based records are vulnerable to both physical destruction and the act of fabrication, while standard databases can have security holes. Moreover, the process of manually gathering physical papers from centralized organizations is both laborious and complicated. To address the concerns above and foster sustainability in the field of education, this study first suggests using Scorechain. This innovative solution integrates blockchain technology into a comprehensive data-management system for managing all student-related data. Secondly, by utilizing the inherent security features of blockchain technology, Scorechain develops a stable multi-role hierarchy, increasing the integrity and reliability of data. This also facilitates the efficient transfer of information among various stakeholders, including parents, recruiters, and educational institutions, thus fostering transparency and accountability. Lastly, the Scorechain system facilitates collaboration and data exchange among universities inside a shared network. Scorechain was constructed using the Rust programming language and is based on the Substrate blockchain architecture. It underwent careful development, testing, and analysis to ensure operational efficiency. The feasibility and long-term viability of Scorechain in genuine educational contexts are highlighted as blockchain technology facilitates seamless integration into the education sector.


Previous numerical studies on the ground state structure of Bose--Fermi mixtures mostly relied on Thomas--Fermi (TF) approximation for the Fermi gas. In this paper, we establish the existence and uniqueness of ground state solutions of Bose--Fermi mixtures at zero temperature for both a coupled Gross--Pitaevskii (GP) equations model and a model with TF approximation for fermions. To prove the uniqueness, the key is to estimate the $L^\infty$ bounds of the ground state solution. By implementing an efficient method---gradient flow with discrete normalization with backward Euler finite difference discretization---to compute the coupled GP equations, we report extensive numerical results in one and two dimensions. The numerical experiments show that we can also extract many interesting phenomena without reference to TF approximation for the fermions. Finally, we numerically compare the ground state solutions for the coupled GP equations model and the model with TF approximation for fermions as well as for the...


Effect of Rhodamine B dye on the growth and properties of L-Alanine Thiourea Bulk single crystals has been reported. The cell parameters and crystallinity of pure and dye admixtured LATU crystals were confirmed by single crystal, powder X-ray diffraction and high resolution X-ray diffraction analyses. The functional groups present in the crystals were confirmed by FTIR analysis. The UV-vis-NIR transmission studies show the optical transparency in the entire visible region of Rhodamine B dye admixtured LATU crystal. The laser damage threshold value significantly enhanced for dye admixtured crystal in comparison with pure LATU crystal. The crystals were further subjected to other important characterizations such as dielectric measurement, micro hardness, thermal and NLO studies. The relative SHG efficiency of Rhodamine B dye admixtured LATU crystal was found to be 1.46 times higher than that of pure LATU crystal.


This paper analyses the frontier between aDBn and aPhD, aiming to clarify in the former the concept ofascientific contribution, analyzing the methodological ...


In order to meet the current status of the widely used USB interface,the data acquisition card USB-6008 made by NI company was studied,its hardware architecture was analyzed,the design process and block diagram of the virtual oscilloscope based on USB interface was given,and the actual measurement was applied.At the premise of technical parameters of the data acquisition card,virtual oscilloscope can achieve the same accuracy as ordinary oscilloscope.In the fields such as file storage and data calculation,virtual oscilloscope has more obvious advantages.


Despite contributing 80% of the food production in developing countries, women receive only partial support for their efforts. There has been, however, a significant shift in the approach towards well being of women from "welfare during fifties", to "development during seventies" to "empowerment during nineties" and to "participation during 2000". Women are also expected to face challenges in food security due to the lack of access to technology. This is because men are more likely to look for work and women have to manage their farm as well as homes. Drip irrigation technology is not only suitable for large farms but also for kitchen gardening. It is also appropriate for operation by women as it does not require use of spade etc as in conventional irrigation. The development of reliable low cost drip system that fits the needs of women farmers in India has long been recognized as a critical need. Three low head drip systems were designed and standardized for vegetables cultivation covering area of 50 to 600 m2 area. Developed systems having bucket, drum, main pipes, portable laterals, and drippers. The drip system operates by gravity from a bucket of 25 litre capacity placed at 1 to 1.5 m height, a drum of 200 litres capacity placed at 3-meter height and drum of 1000 litres capacity placed at a height of 4 meter. About 25 to 50 plants of vegetables can be irrigated by using the single system. This technology is very ideal for rural conditions and small scale agricultural production besides back yard vegetable cultivation in village houses. The management of the bucket kit system is very easy and requires no special skills. Forty (40) family low cost drip systems were installed in the backyards of homes in selected villages especially in those houses where farm women were keen to maintain. Results of these family drip systems are very encouraging. Different bucket kits produced 150 kg of bottle gourd, 90 kg of bitter gourd, 75 kg of okra in one season (March to June). Vegetables production through low cost family drip system and conventional drip system will help achieve nutritional security at village level at nominal cost besides empowerment of rural women.


Molecular characterization is central to personalized cancer medicine in hematological malignancy. As our understanding of the molecular basis of hematological malignancy increases, so does the expectation of patient-derived genomic data to guide risk stratification and treatment selection using novel targeted agents. Whilst the clinical benefit of genomic characterization to guide treatment choices is established in some hematological malignancies (e.g. TP53-mutated chronic lymphocytic leukemia), ensuring that sufficient health economic value is achieved when implementing personalized medicine approaches that involve the use of high-cost diagnostics and therapies presents a significant and pressing challenge. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive non-Hodgkin lymphoma and is curable with frontline chemo-immunotherapy in approximately two-thirds of patients. The majority of the remainder are incurable with standard salvage approaches [1]. Our ability to identify these individuals through assessment of clinical and molecular risk factors is improving. One useful prognostic marker in DLBCL is the classification of disease into subtypes based on the hypothesized cell-of-origin from different stages of B-cell differentiation, designated germinal center (GCB)-like, or activated B-cell (ABC)-like DLBCL [2]. Whilst there are important clinical and molecular associations and confounders, ABCDLBCL has generally been associated with inferior overall survival independent of International Prognostic Index (IPI) in patients treated with standard upfront chemo-immunotherapy, R-CHOP [3,4]. One contribution to the observed difference in outcomes may be the difference in molecular drivers of GCBDLBCL compared to ABC-DLBCL and the incidence of NF-jB pathway dysregulation in ABC-DLBCL leading to activation of pro-survival genes and resistance to conventional chemotherapy [5]. This molecular observation has led to rational attempts to target this pathway with novel agents such as bortezomib, ibrutinib, and lenalidomide resulting in variable success to date [6–9]. In this issue of Leukemia & Lymphoma, Chen et al. [10] apply statistical modeling to evaluate the health economics and cost effectiveness of the upfront treatment of patients with DLBCL according to molecular (GCB/ABC) subtype with R-CHOP± lenalidomide (R2CHOP) based on assumptions from existing phase II trial data [11]. Despite the increased cost of delivery of R2-CHOP, their analysis demonstrates that (i) subtypebased treatment protocols are cost effective compared to uniform treatment and (ii) when the difference in survival benefit between subtypes based on standard treatment is substantial, the most accurate testing method to determine subtype should be used even at a greater cost per test. Given the relative expense of salvage chemotherapy and autologous stem cell transplantation for patients that relapse, upfront treatment with more expensive novel agents was shown to maintain cost effectiveness even when statistically simulated to produce only modest improvements in progression free survival/relapse rates. The validity of any health economic analysis is dependent on the level of evidence supporting core assumptions. Whilst addition of novel agents to RCHOP in order to improve outcomes in poor risk molecular subtypes has been an area of active research, the available evidence is currently largely limited to phase II studies. The forthcoming findings of two phase III, international, randomized, double blind,


Through investigation and documentary research, the author analyzes the problems in building and managing large stadium in China, put forwards some suggestions on how to solve the problems based on the experience of other countries in the world.


This study attempts to test influences Debt to Equity Ratio, Return on Equity and Earning Per Share to the stock prices. This research was carried out on a go public industrial manufacturing company in Indonesia Stock Exchange. A method of the sample in this research using methods purposive sampling with a period of research in 2011 until 2013. The data used in this study is data from manufacturing companies that met the selection criteria. The analytical method used in this research is multiple regression analysis. The research proves that the DER have no significant negative effect on stock prices, ROE have no significant positive effect on stock prices, while EPS positive and significant effect on stock prices. Adjusted R Square value is 0845 it explains 84.5% of the dependent variable can be explained by the independent variable, while the remaining 15.5% is explained by other causes beyond the model. Keywords: Stock Prices, Debt to Equity Ratio, Return on Equity, Earnings Per Share


Light‐duty vehicles account for about 20% of US CO2 emissions. However, new vehicle fuel economy standards have not been significantly tightened since they were first enacted three decades ago. A historical impediment to imposing tougher fuel economy standards has been the long‐standing perception that reducing the mass of a car or truck would make it more dangerous to its occupants in a crash. One often hears that this perception is dictated by "simple physics:" that, all else being equal, you are at greater risk in a lighter vehicle than in a heavier one. Our research on driver fatality risk has found that, when it comes to vehicle safety, all else is never equal. Vehicle mass is not the most important variable in determining occupant safety, not even in frontal crashes between two vehicles. You are at no greater risk driving an average car than you are driving a much heavier (and less fuel efficient) truck‐based SUV. And larger and heavier truck‐based SUVs and pickups impose enormous risks on car occup...


As an important part of the aerospace ground computer detection system,the network downloader plays an important role. This paper describes the overall design of the network downloader with the schematic design of the hardware main modules given,and provides the application of reference for LVDS interfaces,high-speed bus and stacked design in the PCB design to ensure the system hardware reliability. Good performance is achieved in practice.


The results of an advanced supersonic transport aircraft/engine integration study to be used as a detail preliminary design case to assist in the assessment of noise standards applicable to future supersonic transports are summarized. The design considered reflects the application of the advanced technologies which are projected to be available for program initiation in the 1980-1985 time period. Suppression characteristics included were obtained in simulated forward flight in the Rolls-Royce spin rig using a small scale model. The engine size selected produces a noise no greater than 108 EPNdB at any of the three Far Part 36 (Stage 2) defined measuring points and is sized slightly larger than the optimum cruise size to meet this noise constraint condition.


Shotaro Morozumi* Toshiro Komuro** and Seiichi Suzuki*** ' Compacts of molybdenum powder mixed with various amouts Iess than 2 percent of hydrogenated holmium, lanthanum, mischmetall, scandium and yttrium, respectively, were arc-rnelted under an argon atmosphere. Button-like ingots were chemically analyzed for carbon, oxygen and added 'elements in the ingots, tested for the warm workability, and examined by metallography en microstructure and fracture surface. As it was found that scanduim had an excellent effect on the workability of molybdenum, ingots melted with various amounts of scandium up to O.5 percent were tested further for the workability and tensile properties at temperatures from 203 to 353K. Results obtained are as follows : (1) Among the elements added, scandium had the most distinguished scavenging ability in arcrnelting of rnolybdenum. (2) The added elements formed their oxides by the reaction with impurity oxygen in the molten molybdenurn, and the oxides floated off from the molten metal onto the surface as rnolten slags. (3) As a result of deoxidation, the warm workability of molybdenum was improved, on which scandium had the most rernarkable effect. (4) Elements with low deoxidizing ability, e.g. Ho, produced precipitates in the matrix and grain boundaries before they scavenged oxygen enough. (5) Even though elements, e.g. Sc, had high deoxidizing ability, when they remained in excess in molybdenum, the workability of the metal became lower. (6) Molybdenum ingots arc-melted with an optimum amount of scandium, say O.2 percent, had appreciable ductility at about room temperature. (Received May 9, 1983)


Objective To evaluate of clinical value for coronary heart disease patients who cornary artery's internal diameter narrows between 0 and Ⅱ grade with myocardial contrast echocardiography.Methods 50 cases who had typical angina symptoms,the cornary artery's internal diameter narrows between 0 and Ⅱ grade with angiography.those patients must removed off anther disease.these parameters such as LVEDD,LVESD,EF,Dt,Emax,Amax,Emax/Amax,A,β and MBF measured with MCE and echocardiogram.compare perfusion flow and cardiac function with normal team by science of statistics.Results β and MBF was found descend than normal team.There was no significant difference in LVEDD,LVESD,EF,Emax,Amax,Emax/Amax,and Dt.Conclusion MCE can evaluate regional myocardial perfusion and microcirculation.the patients who cornary artery's internal diameter narrows in o to Ⅱgrade by angiography exist blood flow velocity decrease and microcirculation damage but the cardiac function was normal.


Background: Diabetes Melitus (DM) is one of chronic diseases that exist in all countries in the world and keep growing signifi cantly from year to year. There were 366 million people with diabetes mellitus worldwide in 2011, and is expected to increase to 552 million people in 2030. Most of the people with diabetes live in low and middle income countries. Indonesia has 7.3 million people with diabetes in 2011, and is predicted to increase to 11.8 million in 2030. Long term complication from diabetes, both microvascular and macrovascular, can cause insuffi ciently blood supply to hills which can culminate to ulcer infection and will end with an amputation. Goal:The purpose of this research is to know the relationship between foot care and ulcer risk of diabetes foot. Methode: This research method is non experimental- correlational with cross sectional design. In this research, there are 45 respondents. Result:Based on bivariate analysis, it is known that self foot care (p=0.003) and footwear choice and usage (p=0.009 have significant correlation with ulcer risk of diabetic foot. Continued with multivariate analysis, self foot care related to ulcer risk with p<0.005 (p=0.01). People with diabetes who get good foot care have chance to prevent diabetes foot ulcer risk 14 times compared with people with diabetes who get poor foot care. Conclusion: The conclusion of this study are highly correlated independently foot care in the prevention of diabetic ulcers. Based on this study are expected for nurses to conduct a study to diabetic foot conditions and provide education about diabetic foot care. Key words: foot care, foot ulcer, diabetes melitus.


Background: Extensive lymphatic malformations (LM) may cause substantial morbidity. The mTOR (mammalian target of rapamycin) inhibitor sirolimus shows promise for treating vascular anomalies, though response assessment is not standardized. Objective: To retrospectively characterize changes on MRI in extensive LM in children treated with sirolimus. Methods: Twenty-five children treated with sirolimus for extensive LM were included. Baseline MRI was defined as MRI closest to therapy initiation; follow-up MRI was defined as most recent MRI while on therapy. Two pediatric radiologists independently determined MRI lesion volume by tracing lesion contours on all slices (normalized to patient body mass index) and signal by placing an ROI on lesions' dominant portion (normalized to CSF signal), on baseline and follow-up T2-weighted sequences. Inter-reader agreement was determined, and values averaged for further analysis. Volume and signal changes were compared with patient, lesion, and therapy characteristics. Results: Mean (±SD) interval between sirolimus initiation and follow-up MRI was 22.1±13.8 months. Mean lesion volume index on baseline and follow-up MRI was 728 mL/m2 ± 970 mL/m2 and 345 mL/m2±501 mL/m2, respectively (p<.001). Ninety-two percent demonstrated a decrease in volume index >10% (mean volume change -46.4%±28.2%). Volume change was inversely correlated with age (r=-0.466, p=.02). Mean volume change was -64.7%±25.4% in children under 2 years old versus -32.0%±21.6% in remaining children (p=.008). Mean volume change was -58.1%±24.0% for craniocervical lesions versus -35.5%±28.2% for body and extremity lesions (p=.03). Mean lesion signal ratio on baseline and follow-up MRI was 0.81±0.29, and 0.59±0.26, respectively (p<.001). Mean signal ratio change was -23.8%±22.7%. Volume and signal changes were moderately correlated (r=0.469; p=.02). Volume and signal changes were not associated with sex, lesion subtype, sirolimus serum concentration, or interval between sirolimus initiation and follow-up MRI (p>.05). Inter-reader agreement for volume index change was excellent [intraclass correlation coefficient (ICC)=0.983] and for signal ratio change was moderate-good (ICC=0.764). Conclusion: Sirolimus treatment for extensive LM in children is associated with significant reductions in volume and signal on T2-weighted MRI. The volume decrease is greater in younger children and craniocervical lesions. Clinical Impact: The results may facilitate development of standardized MRI-based criteria for assessing pharmacotherapy response of vascular malformations.


The occurrence of a colonial ascidian, Polyclinum indicum (Sebestian, 1952) was recorded estuarine environment at Parangipettai, southeast coast of India for the first time from Vellar estuary. The ascidians, commonly called as "Sea Squirts" is a class in the Tunicata subphylum of sac-like marine filter Phylum : Chordata feeders. ascidians are characterized by a tough outer Subphylum : Urochordata "tunic" made of the polysaccharide tunicin, as compared Class : Ascidiacea to other tunicates which are much less robust. They are Order : Enterogona found all over the world, usually in shallow water, an Suborder : Aplousobranchia important group of marine, sedentary organisms found Family : Polyclinidae distributed from the littoral zone to the deep sea. They are Genus : Polyclinum the major components of fouling community occurring on Species : Indicum the hulls of ships, piers, pilings, test panels, buoys, floats, cables and various other harbor installations. From the MATERIALS AND METHODS


This Deliverable details the agreed vehicle fleets and driver recruitment criteria. Across all VMCs, a wide range of vehicle types, engine types, and driver types is planned for the field trials. This will provide necessary data for SP4 and SP5 to investigate the effectiveness of the ecoDriver solutions and scaling up the impact of the ecoDriver systems.


Oligosaccharidoses are Lysosomal Storage Disorders (LSDs) that result from mutations in genes encoding exoglycosidases, leading to accumulation of unmetabolized N-linked oligosaccharides within lysosomes. Age at onset and rate of disease progression vary among patients. Diagnosis based solely on clinical presentation is often challenging because of overlapping clinical symptoms between these disorders. The aim of this research is to use tandem mass spectrometry (MS/MS) to establish a multiplex method to measure exoglycosidase activities, in dried blood spots (DBS), involved in the degradation of N-linked oligosaccharides using natural substrates. Current fluorometric assays for each exoglycosidase using specific 4-methylumbelliferyl (4MU) substrates allow enzyme activities to be determined separately from a variety of human tissue sample types. A universal buffer was established by comparing these assay conditions to allow multiplexing of the exoglycosidases in a single vial. Initial attempts to develop an enzyme activity assay using disaccharides as the starting substrate and by monitoring unique monosaccharide products by MS/MS after exposure to an enzyme source from cultured skin fibroblasts were unsuccessful due to interfering endogenous hexose isomers. Taking another approach, multiplexing was successfully demonstrated for P-Galactosidase and P-Hexosaminidase using alternative substrates. 4MU and paranitrophenol (PNP) conjugated to particular monosaccharides allowed 4MU and PNP products to be measured and enzyme activities to be calculated. Here, we provide a proof of principle that MS/MS technology can allow simultaneous multiplexing of several enzyme activities using distinctive starting substrates. A multiplex assay for the remaining exoglycosidases can still permit the development of an Oligosaccharidoses screening test to assist clinical diagnosis.


Abstract A comprehensive study of 18 % Ni maraging steel welds is done in order to determine the suitability of repair welding of aluminum die-casting dies and to prolong the in-service tool life. This study emphasizes the influence of welding parameters and post-welding precipitation annealing heat treatment on the welds' mechanical and metallurgical properties. A series of U-grooved specimens of 1.2344 tool steel is prepared. These grooves are filled with 1.6356 maraging steel as filler wire using multi-pass Gas Tungsten Arc welding. The metallurgical properties of the filler welds, in the as-welded condition and after precipitation annealing with a series of different parameters, are studied. The influence of preheat temperature, heat input during welding, and hot working of maraging steel welds is evaluated regarding mechanical and metallurgical properties. The response surface models for the prediction of mechanical properties (i. e. hardness, toughness, tensile strength, and yield stress after post-welding heat treatment) are developed. The results show that metallurgical and mechanical properties significantly depend on welding technology and post-welding heat treatment parameters. Gas Tungsten Arc welding with low heat input permits the omission of solution heat treatment after welding, while hot working of welds during welding increases the mechanical properties. Developed models for the prediction of mechanical properties enable selection of precipitation annealing parameters for a particular application based on desired mechanical properties.


A 26-year-old man presented with coarse facies, recurrent cutaneous cold abscesses, upper respiratory troct infection and candidiasis since infancy. Laboratory investigations showed extremely high serum IgE (270) 10/1) level and pus culture from an abscess grew coagulase positive staphylococcus and Pseudomonas aeruginosa. Besides surgical drainage of the abscess and a short course of cephalexin, zinc sulphate (220 mg/day) was administered orally for six months. All lesions healed within a fortnight and clinical remission was observed for one year on follow up.


1. The severity of herpetic infection, of mice varied according to the site of inoculation, decreasing in the following order: cornea, skin of abdomen, pad of hind foot, tail. 2. The preliminary treatment of the foot pad or tail with methylcholanthrene increased the susceptibility to herpetic infection to a limited extent. 3. Two-week-old mice showed a much greater susceptibility to herpes virus inoculated on the tail or on the pad of the hind foot than did adult mice. 4. The HF strain of herpes virus, after more than 125 serial brain-to-brain passages in mice, possessed high virulence for cutaneous tissues of mice and showed no important differences in this respect from a recently isolated strain (Klee) of herpes virus.


on presence in VR: A survey. Journal of Cyberpsychology and Behavior, 4(2), 183-201. Sheridan, T. B. (1992a). Musings on telepresence and virtual presence, telepres ence. Presence: Teleoperators and Virtual Environments, 1, 120-126. Sheridan, T. B. (1992b). Defining our terms. Presence: Teleoperators and Vir tual Environments, 1(2),272-274. Sheridan, T. B. (1996). Further musings on the psychophysics of presence. Pres ence: Teleoperators and Virtual Environments, 5, 241-246. Simons, H. W. (1976). Persuasion: Understanding, practice and analysis. Read ing, MA: Addison-Wesley. Skalski, P., & Tamborini, R. (2007). The role of social presence in interactive agent-based persuasion. Media Psychology, 10(3),385-413. Skalski, P., Tamborini, R., & Westerman, D. (2002). The Development of scripts through virtual environments. Paper presented at the 88th annual meeting of the National Communication Association, New Orleans, LA. Slater, M., & Wilbur S. (1997). A Framework for Immersive Virtual Environ ments (FIVE): Speculations on the role of presence in virtual environments. Presence: Teleoperators and Virtual Environments, 6(6), 603-616. Slater, M. & Usoh, M. (1994). Body Centered Interaction in Immersive Virtual Environments. In Thalmann & Thalmann (Eds.) Artificial Life and Virtual Reality (pp. 125-147). Chichester, UK: Wiley. Soukup, C. (2000). Building a theory of multi-media CMC. New Media & Society, 2(4), 407-425. Steuer, J. (1992). Defining virtual reality: Dimensions determining telepresence. Journal of Communication, 42(4), 73-93. Stout, P. A., Villegas, J., & Kim, H. (2001). Enhancing learning through use of interactive tools on health-related websites. Health Education Research, 16(2), 721-733. Sundar, S., Kalyanaraman, S., & Brown, J. (2003). Explicating web site interac tivity: Impression formation effects in political campaign sites. Communica tion Research, 30(1), 30-59. Usoh, M., Arthur, K., Whitton, M. C., Bastos, R., Steed, A., Slater, M., & BrooksJr., F. P. (1999). Walking> Walking-in-Place > Flying in Virtual Envi ronments. In Proceedings ofSIGGRAPH. (pp. 359-364). Los Angeles, CA: Association for Computing Machinery. Webster, J., Trevino, L. K., & Ryan, L. (1993). The dimensionality and corre lates of flow in human-computer interactions. Computers in Human Behav ior, 9,411-426. Welch, B. (1999). How can we determine if the sense of presence affects task performance? Presence: Teleoperators and Virtual Environments, 8(5), 574-577. Witmer, B. G., & Singer, M. J. (1998). Measuring presence in virtual environ ments: A presence questionnaire. Presence: Teleoperators and Virtual Envri onments, 7(3), 225-240. Wu, G. (2006). Conceptualization and measuring the perceived interactivity of websites. Journal of Current Issues and Research in Advertising, 28, 87-104.