Abstract : The research supported by this grant is intended to evaluate Rak mRNA expression in both tumor tissue and breast cancer cells and to determine whether inhibiting RAK is a feasible approach to breast cancer therapy. To accomplish this goal two different assays of gene expression have been devised. The first method is a traditional competitive RT-PCR system in which a homologous competitor RNA is used as a standard. The second method involves the use of an electrochemical biosensor being developed in our lab. The biosensor is designed to detect the abstraction of electrons from guanine bases in surface immobilized target RNA's or RT-PCR products. This report describes the development of a rapid electrochemical method that has detected Rak RT-PCR products. Preliminary characterization of this system has determined the sensitivity limit of this system to be 60 amol/sq mm of electrode. In addition, results from competitive RT-PCR experiments on Rak mRNA have revealed that RAK is expressed in BT-474 cells at a level of roughly 100 zmol/micrograms total RNA.


Professional manual transcription of speech is an expensive and time consuming process. This paper focuses on the problem of combining noisy transcriptions frommultiple non-expert transcribers, where the quality of work from each worker varies. Computing transcriber reliability is a difficult task in the absence of gold standard reference transcripts. Three simple metrics for quantifying this reliability without using a gold standard are proposed. We create a database of 1000 Mexican Spanish broadcast news audio clips transcribed by five transcribers each through Amazon Mechanical Turk. Combination of multiple noisy transcripts using these reliability scores improves the word error rate of the combined transcript with respect to the LDC gold standard by 8% relative, and the sentence error rate by 4.1% relative, when compared with a combination without any reliability information.


The coercion of the passive voice construction can be interpreted from different perspectives such as traditional transformational grammar,functional grammar and cognitive grammar.A sentence of passive voice presents a different arrangement of the information of a sentence of active voice and there are various reasons accounting for its coercion.This paper focuses on these underlying reasons and illustrates with many examples from the perspectives of verb characteristics and cognitive context.Meanwhile,it also probes into the application of passive voice construction.


Menetrier's disease is a rare form of protein-losing gastropathy characterized by giant gastric folds, hypoalbuminemia and achlorhydria. The etiology is unclear although infections like helicobacter pylori and cytomegalovirus have been implicated in some cases. We report a case of 43-year-old male with human immunodeficiency virus who was diagnosed with Menetrier's disease. This appears to be the first such case described in the literature with these two coexisting conditions. The patient had no evidence of infection with either Helicobacter pylori or cytomegalovirus. He continued to remain symptomatic especially with persistent weight loss and underwent total gastrectomy with excellent clinical response. The present report describes the clinical features, endoscopic, operative and histological findings, and response to total gastrectomy. We discuss the causes of Menetrier's disease and raise the possibility of human immunodeficiency virus having a potential causal association with the disease.(J Dig Endosc 2010;1:22-25)


Evidence of lipoxygenase activity on grapes (variety Carignane) was obtained by four different methods: oxygen uptake enzymaticly catalyzed in the presence of linoleic acid; increase in absorbance at 234 nm by the action of a partially purified enzyme on linoleic acid; inhibition studies by elaidolinoleic acid and cyanide ions; and isolation and identification of isomeric hydroperoxides by HPLC and GC-MS. The results obtained by HPLC show that, after the action of grape enzymes on linoleic acid, 80% of 13-hydroperoxides and 20% of 9-hydroperoxides are formed. These results agree with the formation of C 6 aldehydes and alcohols from C18-hydroperoxides. Hypotheses concerning the destiny of 9-hydroperoxides are discussed.


In materials with a high magnetization, spin‐wave‐relaxation processes associated with the dipolar interactions will be very strong. The general features of these interactions are discussed in relation to various parameters of the problem. In particular the three‐spin‐wave splitting process is treated in the long‐wave‐length or low‐wave‐vector k limit, and results are presented for this case. Because of the complexity of the final expression the results are presented as an integral which is easily evaluated numerically. This expression gives a value for the linewidth contribution of this process in the low‐k portion of the spin‐wave spectrum.


In the present dynamically changing markets, for an efficient and effective supply chain to take place, it is necessary to focus on the stage of supplier selection. Supplier selection helps in reducing the costs, improve the quality and deliver the products on time, thereby enabling the  organizations to survive the rising competition in the current scenario of global competing environment. This mainly increases the importance of effective supplier selection in manufacturing industry. In this study, in  order to investigate the supplier selection in supply chain management, a questionnaire instrument is applied to companies of Indian manufacturing industry which is being mainly affected from the increasing global competition. A factor analysis is applied to the findings of questionnaire instrument to explore the supplier selection criteria of Indian manufacturing industries.


This paper has investigated the kinetics of limited hydrolysis on rice residue with Alcalase 2.4L FG by pH-stat method.The factors including reaction temperature,enzyme concentration,substrate concentration,pH value and reaction time were discussed and figged out for the reaction.Discussed the kinetics characteristics of the reaction catalyzed by the enzyme.The critical substrate concentration was worked out theoretically as 22.25g residue per 120mL water.The hydrolysis kinetics model was established and proved accurate.The RSD is within 10% in test experiments.


Failure of aspirin to suppress thromboxane production and therefore to inhibit platelet aggregation has been linked in vitro to inadequate protection against atherothrombotic events. Millions of people with heart disease who take aspirin need to know whether it is effective for them. Not finding out whether the patient is aspirin resistant would be comparable to diagnosing someone with high blood pressure, giving him medication and then not monitoring his blood pressure.


The paper presents the strategy of redevelopment of the post-industrial King's Cross area in London – one of the biggest European investments in the last years (the surface of approx. 67 acres), which could be considered the perfect case study for similar works.The author described in details the investment process, as well as the principles and effects of functional and spatial changes that have led to creation of the new system of open space, adaptation of selected post-industrial buildings for new functions (also the buildings proclaimed as a monument) and also fostering a new urban dimension to the wastelands. Detailed architectural issues are presented on the example of 3 squares: Granary Square, Pancras Square and King's Cross Square. Field research was realized from 2011 to 2016.


Nitrate is the main form of nitrogen absorbed by plants. Leaching of nitrate can contaminate groundwater. The measurement of soil nitrate with conventional methods is less practical, takes a long time, and requires a lot of costs. Measurement of variables that affect the presence of soil nitrate can be an alternative solution. The application of prediction models is proven to save time and cost. Complexity problems can use the ANN model. This study aims to developed prediction models for soil nitrate use the ANN model. The measurable parameters such as solution volume, soil moisture, and soil electrical conductivity were used as input parameters for the model prediction development. The samples use oven-dry soil that was added nitrate solution with several variations. The measurement of parameters was carried out in three replications. The training and validation of the ANN model resulted in RMSE values of 1, 0840029 and 1, 000646 then R2 values were 0.973 and 0.970. The ANN model can be an alernative to predict soil nitrate at different monitoring volumes.


Foreword ix John Friend Editor s Introduction xiv Liz Stillwaggon Swan Acknowledgments xxvi PART 1 COMING INTO THE SPACE: WHAT IS YOGA? 1 1 How Yoga Won the West 3 Jennifer Munyer 2 Will I Find My Guru in India? 15 Kieran McManus 3 The Seeker: How Yoga is Meeting Changing Western Spiritual Needs 24 David Robles 4 Men, Sports, and Yoga 36 Barbara Purcell and Andrew Shaffer 5 Standing on Your Head, Seeing Things Right Side Up 47 Steve Jacobson PART 2 THE ASANAS: YOGA AND THE BODY 59 6 Help! My Philosophy Teacher Made Me Touch My Toes! 61 Ken Burak 7 Man a Machine, Man a Yogi: Why Yoga s Critics will Come Around 73 J. Neil Otte 8 Yoga for Women? The Problem of Beautiful Bodies 84 Luna Dolezal 9 The Feeling of Beauty: A Yoga Project 94 Nicole Dunas 10 Picturing Yoga: Yoga Journal and the Perfect Form 106 Debra Merskin PART 3 PRANA: YOGA S VITAL ENERGY 117 11 My Guidance Counselor Always Said I d be a Great Yoga Student 119 Eric Swan 12 Balance in Yoga and Aristotle 129 Leigh Duffy 13 Healing the Western Mind through Yoga 139 Abby Thompson 14 The Path to Happiness Begins with a Journey Inside 149 Jim Berti PART 4 YAMAS AND NIYAMAS: ETHICS AND YOGA 159 15 Get Out of My Way! I m Late for Yoga! 161 Jeff Logan 16 Yoga Off the Mat 166 Julinna Oxley 17 Becoming-Frog: Yoga as Environmentalism 178 Megan M. Burke 18 Yoga and Ethics: The Importance of Practice 187 Paul Ulhas MacNeill 19 Why are You Standing on my Yoga Mat?! 200 Heather Salazar Notes on Contributors 212 ?


The demand projection of power grid materials can furnish an effective support for the management of power grid materials. Due to variations in the data distribution of individual districts and diversity of materials, a single forecasting model is incapable of accurately predicting the demand for all types of materials. Moreover, for the data-driven network model, the effect of the model has a strong correlation with the quality of its input parameters. To address these problems, this study proposes a power grid material demand forecasting model based on feature selection and multi-model fusion. The first step in this regard is the usage of Pearson coefficient in the selection of main characteristic parameters from original parameters and using them as the input of the network model. Then, stacking fusion algorithm is used to fuse multiple basic models. At last, the proposed method mentioned in this study is tested on a real dataset. The results depict that the proposed method can fully integrate the advantages of various basic models with higher accuracy and generalization ability.


Neoplasta Coquillett is distributed in the New World. The male of N. fortiseta Smith and five new species collected in the Brazilian states of Santa Catarina and São Paulo (N. lobata sp. nov., N. longicornis sp. nov., N. macdonaldi sp. nov., N. nigrithorax sp. nov., and N. spinulosa sp. nov.), are described and illustrated. A key to Brazilian species is provided.


We show that the combination of charge and dipole conservation---characteristic of fracton systems---leads to an extensive fragmentation of the Hilbert space, which in turn can lead to a breakdown of thermalization. As a concrete example, we investigate the out-of-equilibrium dynamics of one-dimensional spin-1 models that conserve charge (total $S^z$) and its associated dipole moment. First, we consider a minimal model including only three-site terms and find that the infinite temperature auto-correlation saturates to a finite value---showcasing non-thermal behavior. The absence of thermalization is identified as a consequence of the strong fragmentation of the Hilbert space into exponentially many invariant subspaces in the local $S^z$ basis, arising from the interplay of dipole conservation and local interactions. Second, we extend the model by including four-site terms and find that this perturbation leads to a weak fragmentation: the system still has exponentially many invariant subspaces, but they are no longer sufficient to avoid thermalization for typical initial states. More generally, for any finite range of interactions, the system still exhibits non-thermal eigenstates appearing throughout the entire spectrum. We compare our results to charge and dipole moment conserving random unitary circuit models for which we reach identical conclusions.


The present study was carried out with a view to compute the cost of cultivation of Ghritkumari on basis of cost concept and measuring financial feasibility of the cultivation. Total 80 Ghritkumari cultivating farmers were selected using multistage sampling and to obtain results cost concepts were employed. The result of the study revealed that the cost A1 and cost A2 was found to be similar because the farmers cultivate Ghritkumari crop on their own land. The net present value (NPV) at 15 per cent discount rate was found to be ` 55317.16 for overall farm size. The net present value (NPV) calculated at 10 per cent and was found ` 67213.64 overall farm. The internal rate of return (IRR) was found 36 per cent on overall farm. The benefit cost ratio was found 1.17 at 15 per cent discount rate and 1.19 at 10 per cent discount rate on overall farm. Farm business income, family labor income and farm investment income was found to be ` 83143.24, ` 73909.69, ` 78589.59 highest during 3rd year of Ghritkumari cultivation, respectively. Hence more emphasis should be given to increase Ghritkumari cultivation. The government support helps in better production and marketing of Ghritkumari crop.


A comparative analysis of management accounting articles from the technical journals of the National Association of Accountants in each of the periods 1919 to 1925 and May to June 1975 discloses changes in the nature of the articles and of their authors.


Abstract: This study first outlines the classic Marshallian and Weberian theories of industrial agglomeration, highlighting the difference between Weber's theory, which "discusses the process of agglomeration emergence, based on predictable profit, from a state of nothingness," and Marshall's theory, which "discusses the process of continued self-reinforcement of existing agglomeration." Consequently, one cannot expect to understand the dynamism of industrial agglomeration by viewing these two theories separately. This study integrates the two theories to identify a framework for viewing industrial agglomeration dynamically. Specifically, this paper pays particular attention to "gatekeeper"-type companies, which capture the demand from markets outside the industrial agglomeration and make use of networks within the industrial agglomeration to meet that demand.Keywords: industrial agglomeration, localized industry, internal economies, external economies, gatekeeperIntroductionGenerally speaking, the existing theories on industrial agglomeration fall into one of two branches: A. Marshall or A. Weber (Matsubara, 1999; Sumiya, 1971). The former, which could also be called small to medium enterprise theory, assumes the prior existence of industrial agglomeration and examines mechanisms for the "profit of agglomeration" generated only after the agglomeration has emerged. Fundamentally, this school asserts that external economies operate through agglomeration. The latter, which could also be called the location theory, examines why industrial agglomeration emerges without assuming the prior existence of industrial agglomeration. Fundamentally, this school asserts that agglomeration emerges in geographically advantageous locations. In short, the Marshall school focuses on the function of the industrial agglomeration as a system, while the Weber school focuses on ex-ante rationality behind the emergence of the industrial agglomeration system. Since there are major differences between the two schools in terms of their views on companies and their approach, they tend not to refer to each other. However, it is necessary to take a dynamic perspective that incorporates both emergence and function in order to consider policies on industrial agglomeration.This study discusses the possibility of integrating the Marshallian and Weberian schools, and advocates the necessity of focusing on the existence of "gatekeeper"-type companies, which capture the demand from markets outside the industrial agglomeration and make use of networks within the industrial agglomeration to meet that demand.Marshall's Localized Industry TheoryChapter 10 "Industrial Organization, Continued. The Concentration of Specialized Industries in Particular Localities" of Marshall's Principles of Economics discusses "localized industries" (Marshall, 1920). Directly before Chapter 10, Marshall divides the economies arising from an expansion in the scale of production into two classes: internal economies, generated by the expansion of individual businesses, and external economies, generated by the expansion of the general expansion of the whole industry. Marshall goes on to state that Chapter 10 will discuss localized industries because external economies are mainly seen in localized industries, which are the concentration of many small businesses of similar characteristics in particular localities.Marshall begins Chapter 10 by stating the causes for creating localized industries. For example, in one particular locality, localized industries have originated from family groups expanding into villages. In another locality, localized industries have come into existence because of natural conditions (such as soil and climate characteristics, and proximity of mines and quarries in the neighborhood, or easily accessible by land or water). Other reasons include the patronage of a court, or the systematic summonsing of artisans by rulers to build a town. …


This study investigated the influence of chronic oral nifedipine on the hemodynamic effects of halothane or isoflurane anesthesia in dogs. Under general anesthesia with fentanyl and 3:1 N 2 O/O 2 inhalation mixture a left thoracotomy was performed and two needle force probes were placed in the left ventricular wall to measure myocardial force of contraction


The construction, distribution and management of public housing are important social problems which are related to social fairness and the basic right of citizens. So it is meaningful to set a series of indicators which can objectively indicate the performance level of public housing during the whole duration of construction and distribution. However, former studies focus on the performance of time, cost, quality and site, which can only demonstrate the core problem partly. Based on literature review and expert interview, this paper set a series of indicators which can systematically indicates the performance level of public housing from the aspects of decision making, planning, procuring, constructing, distributing and maintaining. Indicators selected in this paper can be easily quantified, even though some strongly subjective indicators can be studied with appropriate method. Fuzzy Synthetic Evaluation Model is used to build a model to evaluate the performance level of public housing. At last, this paper applied the evaluation model to several real projects in Harbin to research problems that exist in Chinese Public Housing. Results implied that government should pay more attention to the period of planning and distributing, and this paper provided some policy advice at last to help low-income family to live a better life.


Most of us have a story to tell about how we ended up choosing the field of special education. Especially those of us over a certain age. My own personal route began on a dirt road in Korea one wintry morning over thirty years ago. As a regular U.S. Army officer conducting reconnaissance patrols, I came across a child dead and frozen to the road. He died, I suppose, of exposure but the ice holding him fast to the dirt was to me the final indignity. I knew then that children are the forgotten victims of war. I knew then, instantly, that I wanted to help the children, not hurt them. And so I ended my military career as soon as possible and turned to education and-at least back then-to the forgotten ones of education, the kids in special education. Now I am half a world and half a lifetime away from that Korean morning. And I feel somehow vindicated that these last three decades have proved what I felt viscerally that day: the universal value of a child, any child. The completeness of his vulnerability, her endless possibilities, these are not constrained by where or who the child is. It is something that almost all of us reconize and agree to. It is why Saddam Hussein let the captive children leave Kuwait and why they were the first on the lifeboats on the Titanic and why today's political and social realities touch all children. Today's realities dictate that what happens in the rain forests of South America is as relevant to us as the unification of Germany and the drive for equality by the black South Africans. In today's society, the economy of Japan affects the financial stability of the world and the Persian Gulf, for good or ill, controls the developed countries' destiny. Today's world has at last become the global village so long envisioned. Global economies, global solutions, and global awareness of the value of the next generation become more obvious and more necessary with each passing minute. At last humanity is forced to recognize the significance of the insignificant: This one tiny insignificant planet is our village. But a village can be a good place to grow up. Consider the mores of villages and small towns: All children are watched over and watched out for by all the villagers. If Tommy swings a cat, Tommy's mother will know and soon, because someone in the village will tell her preferably not the cat's owner). Now that our village has grown to encompass our fragile world, Tommy's cat-swinging is not a local problem; it's not a Belgian problem, a Mexican problem nor even tile cat owner's problem. Tommy's behavior becomes the problem of whoever can offer the best solution. That is what a child-centered global village can offer us. Children in the mines and factories are not allowed now. Children as small adults to be seen and not heard is a discredited philosophy. Indeed, the village is moving toward a recognition of the rights of children. And when the child-centered global village does come, CEC must be ready. It is time now more than ever to renew our international efforts, not because they are necessary for the prestige of the association but because the children deserve the best we can give them. And in many cases the best in special education is a CEC member. Historically, CEC has had an on again, off again love affair with international special education that in many ways parallels the conflicting foreign outlook of both the U.S. and Canada. Both countries have at times in their history followed an isolationist policy. But isolationism is like the grand mansions of a century ago: Nobody can afford their upkeep. Time now for the affordability of joint commitment to agreed-upon goals. Precedent of such international commitment abounds in CEC's early history. …


The dehydrogenation of cyclohexene over carbon deposited on alumina, C/Al2O3, which was prepared by contacting hydrocarbons such as cyclohexane, cyclohexene and cyclohexanone with alumina surface at ≥823 K, was investigated under non-oxidative conditions. The deposited carbon was identified as condensed aromatic hydrocarbon with graphite-like structure in the results of XRD and 13C NMR measurements. It was found that the dehydrogenation activity was generated on alumina by carbon deposition: the dehydrogenation of cyclohexene proceeded over C/Al2O3 at 773 K, while the isomerization to methylcyclopentenes proceeded over pure alumina without carbon. The selectivity to dehydrogenated products such as benzene and 1,3-cyclohexadiene was maximized at a specific carbon content. The disproportionation of cyclohexene into benzene and cyclohexane proceeded over C/Al2O3 above the specific carbon content. Unpaired electrons
 observed in the EPR measurement are related to the ratio of dehydrogenation and disproportionation, whereas the dehydrogenation activity is not related with the unpaired electron content.


I drank and smoked at school age. Others picked and took magic mushrooms. Later, when I worked in a pub, some staff always got stoned in the beer cellar, much to my irritation. As a junior doctor, I witnessed the terrible complications of heroin: hepatitis, septicaemia, amputations, and the rest. And in the 1990s, I saw the recreational drug scene kick off—ecstasy, skunk, and then the increasing use of cocaine.

More recently, we have seen the increase in "legal highs," "club drugs," and the abuse of prescription drugs. Every generation seems to have …


: Distributed Denial-of-Service (DDoS) has caused great damage to the network in the big data environment. Existing methods are characterized by low computational efficiency, high false alarm rate and high false alarm rate. In this paper, we propose a DDoS attack detection method based on network flow grayscale matrix feature via multi-scale convolutional neural network (CNN). According to the different characteristics of the attack flow and the normal flow in the IP protocol, the seven-tuple is defined to describe the network flow characteristics and converted into a grayscale feature by binary. Based on the network flow grayscale matrix feature (GMF), the convolution kernel of different spatial scales is used to improve the accuracy of feature segmentation, global features and local features of the network flow are extracted. A DDoS attack classifier based on multi-scale convolution neural network is constructed. Experiments show that compared with correlation methods, this method can improve the robustness of the classifier, reduce the false alarm rate and the missing alarm rate.


Improved cross pressure tolerance has been demonstrated for electrodes containing impregnated seals. Electrodes, cooler assemblies, separator plates and reactant manifolds for the third 10-ft/sup 2/ short stack were completed. Assembly of the third 10-ft/sup 2/ short stack was initiated.


Managing the data for Information Retrieval (IR) experiments can be challenging. Dataset documentation is scattered across the Internet and once one obtains a copy of the data, there are numerous different data formats to work with. Even basic formats can have subtle dataset-specific nuances that need to be considered for proper use. To help mitigate these challenges, we introduce a new robust and lightweight tool (ir_datasets) for acquiring, managing, and performing typical operations over datasets used in IR. We primarily focus on textual datasets used for ad-hoc search. This tool provides both a Python and command line interface to numerous IR datasets and benchmarks. To our knowledge, this is the most extensive tool of its kind. Integrations with popular IR indexing and experimentation toolkits demonstrate the tool's utility. We also provide documentation of these datasets through the \sys catalog: https://ir-datasets.com/. The catalog acts as a hub for information on datasets used in IR, providing core information about what data each benchmark provides as well as links to more detailed information. We welcome community contributions and intend to continue to maintain and grow this tool.


This study aimed at investigating factors considered in the new Indonesian 2013 Curriculum development. Qualitative case study was selected as the research design for this study. The data was collected from a document released by Indonesian Minister of Education and Culture in 2013. Document analysis was utilized as the instrument of data collection in this study. The findings revealed that there are five issues considered in the new Indonesian 2013 Curriculum development.


This publication contains three papers on college student exchange between Japan and the United States. The first paper, entitled "The University of Massachusetts and Hokkaido University: A Case Study in Educational Cooperation," by Barbara B. Burn, describes the long-standing relationship between these two institutions in order to identify some of the main characteristics that have contributed to this relationship and as a means to explore some of the deterrents impediments to educational cooperation between universities and colleges in Japan and the United States. The second paper, "Student Exchanges and the Use of Technology" by Jackson 9. Bailey, discusses the diverse conflicts and difficulties that arise nut of student exchanges between Japan and the United States and argues that these issues must be resolved because effective educational exchange is so important to education and technology in both nations. The third paper, "Morehouse College Offers a New Direction in Japanese African American Relations" by Lee Gallo, describes the in-progress development of a Japan-United States friendship commission and argues for the increased participation of black students in international exchange programs. (JB) *****************************,Y***************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ********************************************************************** U S. DEPARTMENT OF EDUCATION Office or Edvcalionai Research and imptovemeni EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC, r-This document nas been tepioduCed as received Dom the person nr Organization originating rt Minor changes have been made to improve reproduction quality Pointe olview Or opinions statedin inns dOCu men, do not necessarily represent ()pica, OEM posinOn Or Policy NAFSA Working Paper #29


Objective:To evaluate the effects of individualized hemodialysis on lowering the hemodialysis complications.Methods:All together312times of hemodialysis in20chronic renal failure patients were investiˉgated.The clinical effects of two different dialysis methods which included routine dialysis and individualized dialysis were compared.Results:There were a few influences on plasma osmotic pressure and serum natrium in individualized hemodialysis group with good effects and fewer complications.Conclusion:Individualized dialysis could effectively prevent the dialysis complications,promote the dialysis quality together with ensuring the dialysis effects.


With the statistics of the materials of six large-scale juvenile physique surveys from 1956 to 1995 and the materials of national physique survey in 2000,this paper made an analysis of the effects of living environment of different periods on the height.The result showed that a good living environment could improve the height of people by a large degree,on the contrary,it would present obvious negative function which was more evident in baby infancy and the puberty.


Among the techniques to solve the knowledge bottleneck problem of supervised learning models, active learning is a promising method. One of the popular techniques of active learning is uncertainty sampling which, however, often presents problems when outliers are selected. To solve this problem, this paper presents a density-based re-ranking technique, in which a density measure is adopted to determine whether an unlabeled example is an outlier. The motivation of this method is to use not only the most informative example in terms of uncertainty measure, but also the most representative example in terms of density measure. The second effort we made is that a technique of sampling by clustering (SBC) is presented to build a representative initial training data set for active learning. Experimental results of active learning for word sense disambiguation and text classification tasks show that the proposed techniques can improve active learning with uncertainty sampling.


Multivariate statistical methods are utilized for developing statistical quality control techniques for multivariable continuous processes. The performance of univariate Shewhart charts, Hotelling's T/sup 2/ combined with univariate Shewhart charts, residuals based SPC techniques, and parameter based SPC techniques are compared. Control of mean droplet size and droplet size distribution in a spray drying process are utilized to illustrate the techniques discussed.


This study reviewed and evaluated measurement approaches and methods are to judge the compliance with and/or progress made towards meeting Kuwait Environment Public Authority's Ambient Air Quality Standards. By carrying out a continuous ambient air quality monitoring study in the company premises, the effectiveness of existing emission control measures can be easily assessed and adequate measures can be taken to improve the environmental commitment of the Kuwait National Petroleum Company. This paper presents predictions of air pollution (PM10, NOX, NO2 , NH3 , SO2 , H2 S, O3 , CO, THC and NMHC along with meteorological data of Wind Speed, Wind Direction, Temperature, Relative Humidity, Solar Radiation and Rainfall) emitted from a modern refinery plant at Mina Abdullah Refinery area. Our findings indicate that the ambient air quality parameters were well within the limit of the permissible Kuwaiti Standards for ambient air quality. Therefore, the Mina Abdullah Refinery activities are not likely to have any significant adverse impact on the air environment in the vicinity of the Refinery.


An important research question in optical see-through (OST) augmented reality (AR) is, how accurately and precisely can a virtual object's real world location be perceived? Previously, a method was developed to measure the perceived three-dimensional location of virtual objects in OST AR. In this research, a replication study is reported, which examined whether the perceived location of virtual objects are biased in the direction of the dominant eye. The successful replication analysis suggests that perceptual accuracy is not biased in the direction of the dominant eye. Compared to the previous study's findings, overall perceptual accuracy increased, and precision was similar.


The fractal character of fracture surfaces of thick-walled pressure vessels produced in the final fast fracture that terminates low-cycle-fatigue tests is compared with that of fracture surfaces produced in Charpy impact tests in samples of the same high-strength and -toughness steel (ASTM A723) alloy. Slit island analysis yielded fractal dimensions near 1.25 for the Charpy specimens, which is typical of high-strength steel alloys previously studied; however, extremely high fractal dimensions near 1.40 were determined for the low-cycle-fatigue specimens


The trajectories' safety of-V-bar single impulse departure during rendezvous and docking was studied in this paper.First,with the rectangle keep-out-zone,two types of safe free flying trajectories after impulse were defined.Then the sufficient and necessary conditions of these trajectories' safety were put forward and proved.At last,a departure problem with uncertainty was solved and simulated.The results show that the theory of single impulse departure is reasonable and the method to get the solution is available.


This paper explores potential causes of the flattening of the Phillips curve and why they matter for monetary policy. I use a novel open economy nested-CES model to show that an increase in product market concentration (Herfindahl-Hirschman Index) and a higher degree of openness to international trade both lead to a flatter Phillips curve. Within the model, the central bank's optimal policy choices depend separately on these two factors, not just on the resulting slope of the Phillips curve. My model predicts a 30% drop in the slope of the Phillips curve since the 1990s, where the major contribution comes from increases in product market concentration rather than increases in international trade openness. Through a series of policy experiments, I quantitatively show the suboptimality of the choices made by policymakers who are misinformed either about the slope of the Phillips curve or about its causes.


The invention discloses a residential quarter parcel delivery system comprising a control mainframe, an image pickup system, a delivery region access control system, a parcel storage cabinet, a parcel weighing device and a parcel identifying device, which are respectively connected with an interface device through circuits; and the control mainframe is connected with an internet communication module through a circuit. The residential quarter parcel delivery system disclosed by the invention is used for solving the last mile problem of express delivery so as to ensure safer, more convenient and quicker express delivery.


Abstract For sensitivity experiments, a method employing the customary probit theory is given for estimating the mean and standard deviation of an assumed cumulative normal distribution for the case where the levels of stimulus cannot be controlled precisely.


Various combinations of Al4C3, B4C, and carbon were used as sintering aids for pressureless sintering of alpha-SiC (94% 6H+ 6% 15R) powders. Densification behavior, polytypic transformation, microstructural development, and mechanical properties were studied. Appropriate amounts of Al4C3-B4C-C additions could facilitate alpha-SiC powders being pressureless sintered to high densities (>95% TD) at temperatures greaterthan equal to1850°C. Even using an alpha-SiC as a starting powder, many elongated grains developed in the microstructures during sintering at low temperature that might contribute to toughening. Anisotropic grain growth was found to be associated with the faulted structures and the 6H→ 4H phase transformation.


ABSTRACT IMPACT: We describe a novel methodology that combines CRISPR/Cas9-induced double stranded DNA breaks with homology dependent repair from an adeno associated virus (AAV) encoded template to generate single-allele edited isogenic cell line models of cancer-associated mutations with high efficiency. OBJECTIVES/GOALS: Conventional approaches to creating isogenic knock-ins, to model disease-associated mutations, are limited by poor efficiency and loss of the mutant allele on extended culture. We present an optimized editing approach combining CRISPR/Cas9 with Adeno-associated virus, using mutant SF3B1 as a prototype. METHODS/STUDY POPULATION: Left and right homology arms for SF3B1 were PCR amplified and cloned into pAAV-SEPT-Acceptor plasmid (containing a chimeric intron, neomycin resistance cassette and polyA tail). The disease-associated K700E mutation was introduced by site-directed mutagenesis. Single guide RNA (sgRNA) complexed with recombinant Cas9 along with the AAV donor were delivered into K562 cells, G418 resistant clones selected, and screened for integration by PCR. Confirmed clones were then transduced with a doxycycline-inducible Cre-recombinase containing lentiviral vector. Inducible expression of Cre-recombinase and expression of the mutant allele were confirmed by Western blot and Sanger sequencing respectively. RESULTS/ANTICIPATED RESULTS: Targeted-integration efficiencies among the Neo-resistant clones, generated by AAV-alone and AAV+CRISPR/Cas9, were 16% and 94%, respectively. Single cell cloning after Cre-mediated excision of loxp was unsuccessful presumably due to toxicity of the K700E mutation. To overcome this limitation, clones were transduced with doxycycline-inducible Cre-recombinase lentiviral vector. Doxycycline induction of Cre-recombinase resulted in reliable excision of the loxp cassette and expression of mutant allele at about 50% variable allele frequency (as determined by Sanger sequencing). The approach was validated in additional cell lines and for introduction of N-terminal FLAG tag for SF3B1. DISCUSSION/SIGNIFICANCE OF FINDINGS: Combining AAV and CRISPR/Cas9 can generate scalable single-dominant allele mutants with high precision and efficiency compared to AAV or CRISPR alone. Together with inducible Cre-recombinase, our approach can generate isogenic models where the mutation confers a growth disadvantage.


FIELD: transport engineering; bicycles. SUBSTANCE: invention relates to bicycle speed change control devices operated by cable. Intermediate member 18 is connected with bracket 14 by means of hinge pin 38 for turning around area 39 of hinge joint, being cross section of hinge pin 38. Guide surface 55 of cable is arranged visually intersecting area 39 of hinge joint in projection to axis of hinge joint. Intermediate member 18 can be arranged on inner side of bracket 14, and cable guide roller 54 can be arranged on outer side surface of bracket 14. Axis of cable guide roller 54 can be arranged on intermediate member 18 between area 39 of hinge joint and connecting mechanism in form of lever links 58, 62. Invention is aimed at elimination of undesirable tensioning of cable when intermediate member 18 turns relative to hinge pin 38 at changing of speeds. EFFECT: improved accuracy of speed change control. 21 cl, 15 dwg


Comparisons were made between benthic organism samples collected in 1960-61 and 1972-73 from five sites in the Sacramento River between Red Bluff and Knights Landing. The compositions of benthic organisms from both collection periods were similar. In both studies there was a general increase in mean number of organisms per square meter from May to September and a decrease from September to April. The mean number of organisms per square meter, mean number of taxa per square meter, and diversity index were larger for both studies in the upper reach than in the lower reach of the Sacramento River. The 1972-73 data showed variable patterns at a lower taxonomic level in monthly changes at each site, and monthly downstream changes in number of organisms per square meter, number of taxa per square meter, and diversity index. Fluctuations in benthic organism composition at each site within each sampling period may have been caused by sampling different stages of the individual life cycles of each type, or by influences of drifting organisms either from the Sacramento River or its tributary streams.


This article investigates the current sharing and voltage regulation problem of a DC microgrid by a distributed supervisory control method. In the existing secondary control methods, current sharing feedback control loop and voltage regulation feedback control loop are linearly integrated to shift the droop equation. However, the linear combination of two loops may easily offset the control effect of each other, as the control dimension is less than the objective dimension. This fact motivates us to design a distributed supervisory secondary control (DSSC) scheme to achieve a more flexible configuring of each converter. The DSSC consists of two candidate controllers and a supervisor. The two controllers refer to current sharing configuring and DC bus voltage regulation respectively, and the supervisor is to orchestrate the switching between candidate controllers based on the system environment of DC microgrid. Under the proposed DSSC, each converter selects to configure the current sharing or regulates the DC bus voltage according to its need. Theoretical stability analysis is rigorously conducted. Finally, both simulation and experiment results are presented to demonstrate the effectiveness of DSSC.


one, like that of most of his critics. At the same time, his notion of modernity was also not of a poetic nature. He was very well acquainted with the nature of modern, urban-industrial society. Herzl did indeed draw a very clear picture of the political, economic and social structure of Western civilization at the fin de siècle. He emphasized the influence of 'mass politics' on political culture, the conflict between capital and work, the hard conditions of the working class, etc. He even drew a parallel between the European proletariat and the Jews. Both were longing for salvation and were thus prone to utopias or visions which promised them redemption in the near future. He even went as far as to argue that it was impossible to predict what kind of misery would emerge from these future remedies, and had some doubts concerning the influence of advanced technology on modern society. He was not a simple-minded utopian who believed in modern progress. But while he was very cautious about the prospects for socialism and the chances of success in constructing a 'new world', he was very strong in his conviction that the prospects for Zionism were bright. It is correct to describe his Zionism as 'scientific Zionism' (on the model of 'scientific socialism').3° He firmly believed that the new forces created by man during the nineteenth century could be used in the service of progress and humanity. Zionism, in his view, was composed of national aspirations and social longings made possible by the power of science and technology. In other words, while he was very pessimistic about the prospect of a 'European utopia', he believed in the reality of the 'Zionist utopia'. Without trains, steam-power, electricity, etc., the


Though Ernest Hemingway rejects symbolism itself, the basis of his work is symbolic technique. So in order to comprehend his works. it is necessary to analyze his symbolism. This thesis aims to study biblical factors in the works of Hemingway and to show the relations between the biblical factors and subjects of his novels. A biographer noted that Hemingway`s main characters showed his view of life, universe, and christian mind. The continuation of this essay deals with analyzation of the male hero so that all of Hemingway`s works can be seen generalization of their catholicism. Most of the characters who are obsessed with gambling, drinking and sex have lived in Europe. In my opinion, christian symbolism was developed into the sinful human nature of Jake barnes and Santiago. From reflecting on them, we can see a great deal of changes which had occurred from young Hemingway. Strictly speaking, it is possible to destroy humans but humans can`t be defeated. The final end of our physical aspect can only be death. Although the spirit leaves us, the christian legacy of characters remains. Therefore, it leaves an image of sainthood and heroism that remains with us for a long time. In conclusion, this thesis reveals that christian symbolism is soaked into Hemingway`s works.


(57) Abstract: In accordance with the present invention, it is possible to produce a transgenic mammal that is capable of specifically expressing leukemia inhibitory factor in the pituitary. The transgenic mammal of the present invention is useful as an animal model for pituitary disorders. The transgenic mammal of the present invention also relates to compounds which stimulate the production of growth hormone, a compound useful in the treatment of physiological disorders associated with craniopharyngioma, compounds useful in the treatment of physiological disorders associated with pituitary cysts, etc. it is also useful to identify.


The discussion group (DG) consisted initially of a brainstorming about the topic of fast Wafer Level Reliability (fWLR) Monitoring. All different topics were collected and discussed which were mentioned by attendees, at the first night. At the second meeting a work package was started for the generation of a guideline on fWLR Monitoring. It was focused work with an initial report from the German Information Technology Association (ITG) working group, which is also debating the topic fWLR Monitoring.


Introduction: Imaging is a very important procedure in many medical and engineering disciplines. It provides a non-destructive method of examination and exploring the interior anatomy and internal structure architecture of a certain domain. In medicine, different imaging modalities are available and many of them share the same concept, although having different processes to achieve it. Aim of the study: to validate reconstruction of ultrasound images (derived from video format) could yield same results as in case of CT scan (directly constructed from DICOM data). Materials and methods: A wooden model were used to obtain images using ultrasound and computerized tomography (CT), these images were processed to produce a 3 dimensional model. Results: initial results show that the capability of synthesis data from ultrasound imaging modality in a fashion similar to that performed routinely with CT scan data Conclusion: ultrasound imaging is a very popular modality that could be used to compensate the shortcomings of other modalities


The article is an attempt to search for some examples of Polish political and social thought which can be described, from the modern perspective, as communitarian. The currents and figures evoked here are those who tried to conceptualize the vision of Solidarity, namely J. Tischner and J. Kurori, those who prepared the way for it: J. Strzelecki and the group gathered around Wieź, and some earlier traditions of Polish cooperative philosophy (E. Abramowski) as well as the Polish Romantic period. The authors are aware that Polish social philosophy contains quite a lot of communitarian elements, like respect both for community ties and individual freedom, consciousness of the social responsibility of an individual towards his community. Therefore, they limit their task to the presentation of only several exemplary figures whose ideas prove their closeness to the modern communitarianism.


The motion of a pair of counter-rotating point vortices placed in a uniform flow around a circular cylinder forms a rich nonlinear system that is often used to model vortex shedding. The phase portrait of the Hamiltonian governing the dynamics of a vortex pair that moves symmetrically with respect to the centerline---a case that can be realized experimentally by placing a splitter plate in the center plane---is presented. The analysis provides new insights and reveals novel dynamical features of the system, such as a nilpotent saddle point at infinity whose homoclinic orbits define the region of nonlinear stability of the so-called F\"oppl equilibrium. It is pointed out that a vortex pair properly placed downstream can overcome the cylinder and move off to infinity upstream. In addition, the nonlinear dynamics resulting from antisymmetric perturbations of the F\"oppl equilibrium is studied and its relevance to vortex shedding discussed.


9085 Background: Evidence for T cell mediated regression of human cancer in particular melanoma following immunotherapy is strong. Anti-CTLA4 treatment has been approved for treatment of metastatic melanoma and blockade of PD-1 has shown encouraging results. However, it is unknown which T cell reactivities are involved in cancer regression. Reactivity against non-mutated tumor self-antigens has been analyzed in patients treated with Ipilimumab or with autologous TILs, but the size of these responses are modest. Therefore, T cell recognition of patient-specific mutant epitopes may be a potentially important component. Animal model data recently suggested that analysis of T cell reactivity against patient-specific neo-antigens may be feasible through exploitation of cancer genome data. However, human data have thus far been lacking. Methods: To address this we have used MHC class I peptide exchange technology allowing production of very large collections of pMHC complexes, together with a pMHC "combinatoria...


A simplified mathematical model of heat transfer process in double skin façade was presented in this paper. The effects of outside environmental parameters and dimension of façade on the temperature of interior and exterior façade were analyzed and calculated. The results show that the main factor affecting façade temperature is solar irradiance, the temperature of interior and exterior façade would be lowered by using glazing with low absorption coefficient to decrease the effect of solar irradiance on indoor environment. The temperature of interior and exterior façade could be lowered by increasing the depth of façade gap, but the effect of lowering temperature by increasing the gap deeply was not obvious. The research results of this paper will provide theoretical background for the design and popularized application of double skin façade.


OBJECTIVE
To evaluate hemoglobin, leukocyte, platelet counts and red cell distribution width values during acute vivax malaria.

METHODS
This study, which comprises 90 symptomatic vivax malaria patients compared with 52 healthy controls, investigated hemoglobin, leukocyte, platelet counts and red cell distribution width values during acute disease prior to the treatment in vivax malaria, from May 2002 to December 2004 in Adana, Cukurova region, located in the southern part of Turkey, along the Mediterranean coast.

RESULTS
Mean values for hemoglobin, leukocyte and platelet counts in the vivax malaria group in our study were found to be significantly lower in comparison to the control group. Anemia and thrombocytopenia were also observed in the malaria group while not in the control group (p<0.05, p<0.0001). Mean red cell distribution width values were found to be significantly higher in the malaria group (p<0.0001).

CONCLUSION
Our findings indicated that routinely used laboratory findings such as low hemoglobin, leukocyte or platelet counts and especially high red cell distribution width values could present a more supportive clue in the diagnosis of vivax malaria in endemic areas.


A fundamental objective of Hong Kong in the 21st century is a vision of itself as an international cultural metropolis. This sits within a wider culture of change initiated by the comprehensive educational reforms launched in 2000, all aimed at preparing the future workforce for the challenges of the new millennium by encouraging students to take the learning initiative while simultaneously nurturing in them the ability to think and create. At the same time Hong Kong, at both an educational and at a wider, societal level, is a high-stakes, results-based environment generated by a culture of assessment. It is within this context that the article uses Music (through its traditional espousal of cultural values) as a "barometer" of the present climate to report the findings of a survey of Hong Kong secondary students in an attempt to gauge, and consequently articulate, the place of this particular subject within the curriculum. The subsequent confirmation that the cultural aims of the HKSAR are at odds with a mindset which is essentially commercial at heart reveals more than a simple mismatch in


Purpose – The purpose of this paper is to conceptualise the relationship between novels and organizational change and to introduce this special issue of the Journal of Organizational Change Management.Design/methodology/approach – The themes of the special issue are discussed and each paper is introduced.Findings – The relationship between novels and organizational change is a complex, iterative one that should be understood in its historical, political, economic and cultural context. If so understood, novels can enhance our understanding of organizational processes.Originality/value – Although literature and representation in general have been discussed in studies of organization and management before, the specific literary form of the novel has not been theorised in relation to the question of novelty and organizational change.


A computer‐simulation study of a water‐like system is carried out by making use of a two‐dimensional version of the Ben‐Naim and Stillinger potential. The pair potential is set up such that at 0 K it yields a square net structure at low pressures and an interpretation of two square nets at high pressures. The liquid state is surveyed over a wide range of temperature and pressure. Various kinds of molecular distribution functions are derived to see how the hydrogen‐bond network structure depends on temperature and density. The pressure and thermal equations of state are ''experimentally'' determined by a least square fitting to the pressures and energies calculated for about 200 different state points. The well‐known anomalous behavior of liquid water is reproduced at least in a semiquantitative way. The singular properties of supercooled water also are reproduced and their origin is ascribed to the thermodynamical instability. New anomalies are predicted at high temperatures and pressures.


Through analyzing the critical state of the university environment of Chinese schoolyard by survey data,this paper points out the problems of space environment,greening environment,culture environment and community environment caused by expansion,combination and the building of new schools. Finally,the paper points out the new planning consciousness about the university environment and hope to direct the construction of future university environment.


We have calculated phase shifts, analytically and numerically, for an adiabatic long range potential, arising from the interaction of 3 particles in two dimensions. At large distances of the hyper radius r, the effective potential approaches (r 2 ln r)-1. We obtained the low energy dependence of the phase shifts which correspond to such a long range 'tail'. We also studied the contribution to the phase shifts from the short range part of the potential.


(n, k) fork-join queues are prevalent in popular distributed systems, erasure coding based cloud storages, and modern network protocols like multipath routing, estimating the sojourn time of such queues is thus critical for the performance measurement and resource plan of computer clusters. However, the estimating keeps to be a well-known open challenge for years, and only rough bounds for a limited range of load factors have been given. This paper developed a closed-form linear transformation technique for jointly-identical random variables: An order statistic can be represented by a linear combination of maxima. This brand-new technique is then used to transform the sojourn time of non-purging (n, k) fork-join queues into a linear combination of the sojourn times of basic (k, k), (k+1, k+1),..., (n, n) fork-join queues. Consequently, existing approximations for basic fork-join queues can be bridged to the approximations for non-purging (n, k) fork-join queues. The uncovered approximations are then used to improve the upper bounds for purging (n, k) fork-join queues. Simulation experiments show that this linear transformation approach is practiced well for moderate n and relatively large k.


The cellular components are called cell organelles. These cell organelles include both membrane and non-membrane bound organelles, present within the cells and are distinct in their structures and functions. They coordinate and function efficiently for the normal functioning of the cell. The cellular components are called cell organelles. These cell organelles include both membrane and non-membrane bound organelles, present within the cells and are distinct in their structures and functions. They coordinate and function efficiently for the normal functioning of the cell. A few of them function by providing shape and support, whereas some are involved in the locomotion and reproduction of a cell. There are various organelles present within the cell and are classified into three categories based on the presence or absence of membrane.


This is the final version of the Recommendations and Guidelines from the RDA COVID-19 Working Group, and has been endorsed through the official RDA process. The Research Data Alliance (RDA) COVID-19 Working Group members bring various, global expertise to develop a body of work that comprises how data from multiple disciplines inform response to a pandemic combined with guidelines and recommendations on data sharing under the present COVID-19 cicumstances. This extends to research software sharing, in recognition of the key role in software in analysing data. The work has been divided into four research areas (namely, clinical, omics, epidemiology, social sciences) with four cross cutting themes (namely, community participation, indigenous data, legal and ethical considerations, research software), as a way to focus the conversations, and provide an initial set of guidelines in a tight timeframe. The detailed guidelines are aimed to help stakeholders follow best practices to maximise the efficiency of their work, and to act as a blueprint for future emergencies. The recommendations in the document are aimed at helping policymakers and funders to maximise timely, quality data sharing and appropriate responses in such health emergencies.


As the number of vehicles in the world skyrocket over the last few decades, there have been many injuries or deaths from accidents due to all kinds of reasons. In this way, the safety, and especially stability, of vehicles now become an increasingly important research topic. At this moment, different researchers deploy different degrees of freedom (DOF) as they do the simulation studies for Vehicle Stability Control (VSC). Each has its advantages and disadvantages and affects the research in its own ways. In this paper, MATLAB and Simulink are both used to model the vehicles in different DOFs. By comparing the performance of each model, the effects of different DOFs on the VSC are analyzed, proving important ideas for the future of related research. The research concludes that VSC's effectiveness is directly proportional to the number of DOFs. Therefore, future research needs to focus on higher DOFs to improve vehicle safety.


This paper examines the positive impact of the inflows of capital into venture funds on the valuations of their investments in firms and two potential explanations for the relationship. Growth in venture capital commitments is shown to increase the valuation of new investments. This effect is robust to (i) the addition of controls for firm characteristics, public market valuations, and various alternative hypotheses, (ii) an examination of first differences, and (iii) the use of inflows into leveraged buyout funds as an instrumental variable. Interaction terms suggest that the impact of venture capital inflows on prices is greatest in states with the most venture capital activity. Changes in valuations do not appear related to the ultimate success of these firms. The findings are consistent with suggestions that competition for a limited number of good investments may be responsible for rising prices. See also my related papers "Venture Capital and Private Equity: A Course Overview", "What Drives Venture Capital Fundraising?", and "Conflict of Interest and Reputation in the Issuance of Public Securities: Evidence from Venture Capital".


A set of hypotheses was formulated on the basis of available knowledge about non-industrial private forest (NIPF) owners' risk preferences. The empirical material used for testing the hypotheses was gathered in telephone interviews with 130 randomly selected NIPF owners. The results confirm that direct economic risks such as price and cost changes are seen by this group as much more important than indirect economic risks such as biological damage. The forest owners regarded forest holdings as a safer investment than stocks or bank savings. The results on risk attitudes were ambiguous. However, when larger amounts of money were at stake, the forest owners could be considered risk averters and a decrease in absolute and relative risk aversion could be confirmed.


The data acquisition module of the auto-test system of water pump was studied in the paper.The design plan was presented according to the requirements of design.The adoption of the experiment devices for the data acquisition module was verified.The final adoption was: LWGY turbine flowmeter,EAJ 110A Pressure Transducer,NJ torque and rev measurement instrument with NC computer-based torque device and 8902F three-phase electronic parameter measurement instrument.


A statistical model is developed to understand the volume of water drawn from a horizontal water heater in relation to its primary heat replacement. An experiment is designed to obtain unbiased data that can be used to build a model. The model is a combination of linear and multivariate regression-based methods that uses the primary heating duration observed on the water heater's element heating pattern. It is determined that the relation between the primary heating event and the draw volume is linear. Testing showed that ambient temperature differences can increase the precision interval to 16% if not accounted for. Points of test data are used to expand the model and reduce the error to 6%. This method can reduce the complexity of physical models by eliminating the need to consider the complex thermodynamics within the electric water heater (EWH) caused by stratification for this early iteration of the model. Through the use of a simple linear regression model, it is found that a high volume draw at a high flow rate reduces the energy required by the heating element by distributing the concentrated energy at the top of the EWH better. This temperature profile is assumed to be a result of the positioning of the thermostat in the EWH. The ambient temperature is also found to have a significant impact on energy input of the heating element for a draw event.


One kind of Chinese pinyin input method and the remote control using the telephone nine numeric keys, character input Pinyin. In order to input alphabet symbols, using the key pad of the key "2" - "9", and the conversion key distribution, a combination of the phonetic symbols converting the input characters or words. Therefore, to reduce learning difficulties, reducing keystrokes.


This paper describes our editing group's experiences in changing from paper to online documentation and provides insights for other publications groups considering the move to online documentation. We have focused this paper on the changes witbin our editing group however, we feel these changes are pertinent to any publications group, especially to any group with similar job responsibilities. Our Group's Move from Paper to Online Documentation In 1992 the publications group at Tandem Computers in Austi& Texas, responded to requirements from customers and internal field support groups by beginning to evaluate online documentation. After months of thoroughly investigating the available technologies and tools, we chose to use SGML and the DynaText viewer from Electronic Book Technologies, Inc. Because our source files are in both troff and FrameMaker, we also selected a document management tool by PassageSystems and contracted with this company to produce the specific Iilters we needed. We spent many months refining our tools strategy, planning our move to online documentatio~ and then implementing our plan. In the spring of 1995. we delivered our first documentation CD-ROM in suppott of one of our smaller pro~cts. We used this release as aprototype to test our new processes and to evaluate many of our decisions. In December of 1995, we delivered a Permissionto copy without feeall or pmt of thk material is grantedprovided that thecopiesm not madeor distributed for direct comrnemiatadvsntage,theACM copyright nctice audthetitle of thepublicationandits dateappear,andnotice is given thatcopying is by permissionof theAssociationfor Computing Machinery.To copy otherwise,or to mqmbtish, nquim a feeanchr specificpermission. documentation CD that contained 35 manuals to suppon the latest UNIX operating system offering and hardware platform from Tandem. Since December, we have updated and re-released this set of documentation twice. Whh these releases we have accomplished our initial goal of taking existing books and putting them online in a usable way. Now we are beginning to focus on our longer term goals of making our documentation more effective and easier to access. Organization of Our Publications Group Our publications group has six functional group~ writing, editing, graphic desigm technical support, QNproduction, and release coordination. The responsibilities of each group areas follows:


This paper describes an investigation into a novel miniaturized microwave matched band-stop filter with pseudo-infinite attenuation for the enhancement of wireless link on floating production storage and offloading (FPSO) vessels. The proposed method is capable to produce almost infinite attenuation even with very low Q resonator and is suitably used to suppress very high power interference signal. Another important feature of the filter is that it possesses matching response at all frequency. The solution can be easily integrated with the existing system with minimum cost and more importantly without interrupting the service. Furthermore, the filter can be switched to exhibit an all pass response by turning "OFF" the PIN diodes incorporated into the filter topology. An experimental prototype will be demonstrated for the proof-of-concept.


STUDY OBJECTIVE: To determine the effect of a "boot camp" for first-year residents to assess their level of proficiency in departmental basic competencies. METHODS: First-year residents were paired with upper-levels for a shift on labor and delivery before their first rotation. Proficiency in competencies, including history and physical examination skills (H&P), use of the electronic medical record system (EMRS), rounding and handoffs, and documentation was evaluated to determine the level of supervision required. Questionnaires were given to all residents 3 weeks later for evaluation purposes. RESULTS: All first-year residents felt that boot camp promoted decreased anxiety, better preparation for first shift and increased EMRS proficiency. Interestingly, 71% noted that it helped them identify areas needing improvement in H&P skills. All upper-level residents surveyed agreed that this prepared new residents for their first shift, 87.5% noticed decreased anxiety, 75% advancement in EMRS use, and 62.5% recognized areas of improvement in H&P skills. Eighty-seven percent of all residents agreed it should continue annually. Duty-hour violations and patient-care efficiency metrics between July and October will be compared with previous years as a hard outcome measure. CONCLUSION: New academic years face steep learning curves and inefficiencies that negatively affect patient safety, efficiency and duty hours. The current "boot camp" decreased anxiety of new residents and better prepared them for the first day of residency. Furthermore, it provided an objective tool for the program director to better determine the level of individual supervision required. Objective measures of effect on efficiency and duty hours will also be presented.


should abstain from all sexual activity. Second, it is striking that Jewish mystics should so extol the virtues of domestic life and value conjugal relations with their wives so highly. One might expect that the natural tendency of the mystic would be to withdraw from physical relationships in order to be able to concentrate on mystic contemplation and spiritual growth. The kabbalists' stress on the necessity and importance of conjugal relations and their incorporation of them into their theosophical system would seem to be an instance of making a virtue of necessity, i.e., the need to oppose the Christian view which valued abstinence and 'celibacy more highly than marriage and sexual relations. Aside from his other achievements in this work, Cohen has laid to rest the notion that the blame for the environmental crisis of our time can be laid at the feet of the Judeo-Christian heritage. Whenever the notion did develop, it was certainly not before the Reformation. Finally, the author has demonstrated the value of scholarly research, based on a thorough knowledge of the sources in their original languages and the necessity of reading these sources on their own terms and in their own contexts. One can only hope that the art the author has herein demonstrated will never be lost. Barry Walfish University of Toronto Library


Hyperfibrinolysis has been observed in patients heavily transfused with solvent/detergent‐treated pooled plasma (S/D plasma). We compared coagulation and fibrinolytic variables in blood containing S/D plasma with blood containing fresh‐frozen plasma (FFP), with and without α2‐antiplasmin or tranexamic acid (TXA) supplementation.


ABSTRACT We replicate, using adult web users, a study comparing advertising effectiveness and content evaluation in print and on the web (Gallagher, Foster, and Parsons, 2000). As in the original study involving students, the replication found that advertising was equally effective in the two media. However, while the original study found that evaluation of an article containing advertising was lower when it appeared on the web than when it appeared in print, this result was not replicated. Examination of two subgroups showed that results for the subgroup resembling the student sample were consistent with the original study. We propose conditions under which student samples are appropriate.


System level verification with scalable and reusable components provides a solution and to develop a complete environment with constrained random testing functional, coverage and assertions. This paper details the design and implementation of SoC's UARTSPI Interface. The UART-SPI interface provides usage for the universal asynchronous receiver/transmitter (UART) to serial peripheral interface (SPI). The SPI bus is assort synchronized serial peripheral interface, it causes MCU to carry on the communication with each kind of peripheral by the serial mode to exchange the information. .This paper introduces the procedure of delivering the information from CC2430 with wireless transceiver function interface to the C8051F120 by serial peripherals interface.


Interval training method is used as one of the means of training methods among various other methods, applied for athletes' training in different sports. H. Reindel, H. Roskamm (1959) were the first having put a highlight on this training method in a scientific literature. In 1960, I. Astrand et al. provided detailed studies on the impact of interval training method on O2 intake (VO2), pulse rate (PR), blood lactate (La) concentration and other physiological processes in athletes' body when performing different workouts bearing the interval character. H. Reindell et al. (1962) used to analyse the physiological essence of interval workouts and grounded the practical use of them in developing athletes' aerobic capacity, i.e., ability of muscles to use O2, as well as functional capacity of blood respiratory system. Lately, increased attention was paid to interval workouts when combining intense work of short-term with that of low intensity. However, there is a shortage of investigations dealing with the body changes caused by interval workouts, applied in the process of elite kayak rowers. It is of paramount importance to identify the change of oxygen intake intensity in kayak rowers' working muscles, as well as the differences of oxygenation in the workouts of different duration and intensity. The aim of the work was to explore and compare the effect of high intensity interval and repeated training workouts on muscles' aerobic metabolism in elite kayak rowers. Organization and methods of the research. Two elite kayak rowers (aged 29 and 30) participated in the research. After 10 min warming-up, the athletes performed complex exercise, which consisted of repeated 6 min duration work of 80% intensity at second ventilation threshold (2VAT), which was followed by 6 min sitting at rest, and later on they carried out the workout of 6 min duration by the above mentioned intensity. Afterwards, after 6 min rest, they performed the interval workout of 6 min duration with 10 s intense work by 300 W power at the limits of critical intensity level (CIL) when VO2max is reached. Having performed this high intensity workout, the athletes had 30 s rest filled with light work, and after they repeated the workout overcoming the distance of high intensity. After a passive rest of 6 min, the athletes used to twice repeat the work at the same afore indicated intensity. Our research proved it to be effective in elite kayak rowers' training an application of interval workouts with short (10–20 s) high intensity distances, aimed at the development of muscles aerobic metabolism. Under such conditions, muscles perform great mechanic work without acidifying body. It was found that general O2 consumption of kayak rowers during interval workouts is less comparing to the same work of the same duration by less intensity. VCO2 in exhaled air did not reach VO2 level in any case of the workouts. These indices were greater when performing 6 min duration distances evenly than using interval method. It appears to be purposeful to further investigate effectiveness of interval workouts aiming at expanding the possibilities in elite kayak rowers' training. Keywords: kayak rowers, aerobic metabolism, muscles oxygenation, interval method. DOI:  http://dx.doi.org/10.15823/sm.2018.7


Advanced aircraft and high-power gas turbine engines need high-temperature gas turbines with low aspect ratio blades. The required aspect ratio can be obtained by increasing the chord length without changing the blade length and the ratio of the average turbine diameter to the blade length. Increasing the chord lengths of rotor blades in hightemperature and high-pressure gas turbines can significantly reduce the number of blades, as well as mean-profile and local heat transfer coefficients from the gas to the blade. At the same time, bending stresses in turbine stages decrease at different aspect ratios of rotor blades. In this paper, the influence of the radial clearance determined by the chord length of fixed length blades on the basic performance indicators of gas turbines with different aspect ratios of rotor blades is studied experimentally under the conditions of turbine stages. The obtained results are recommended for use in the design of gas turbine engines of various purposes.


At present the problem of state sovereignty in the process of globalization is a heated issue of international law research. This article, based on the analysis of the definition of globalization, is to expound a few theories about relationship between the globalization and the state sovereignty, and discuss interaction of the globalization and the state sovereignty. It also points out that the state sovereignty is not being fundamentally transformed by globalization, but it must suit new historical conditions. The author also put forwards some suggestions on China's countermeasures to this issue.


We used industry-based cost estimates4 that were lower for seat belts and higher for installed air bags than those used in the study by Graham et al. Air bag component and installation costs vary, but are generally higher than the $278 estimate used by Graham et al (who did not include installation). It also was unclear why the cost of all seat belts in the vehicle ($57) was included together instead of using the cost of each belt in the individual front seats ($30). We feel the latter may be more appropriate, because the analysis is highly sensitive to costs of equipment.


Shame, Guilt and Alcoholism — Treatment Issues in Clinical Practice, 2nd edn. By Ronald Potter-Efron. The Haworth Press, New York. 237 pp., $24.95. ISBN 0-7890-1517-X.

The first edition of this book appeared in 1989 and this new edition incorporates developments in the psychology of guilt and shame. The author is an experienced counsellor in mental health and addictions. Those reared on the importance of defining terms in a way that is categorical and susceptible to reproduction may worry about the elusive nature of the concepts involved here. He describes shame as 'a painful sense of one's basic defectiveness as a human being' and guilt as an 'uncomfortable self …


This paper has a thorough analysis to CHAP and points out its security flaws. By using cryptology, ID authentication technique and USB Key technique, it has been improved. Then designs UBAP protocol which is an ID authentication protocol under environment based on USB Key. It is a one-time password authentication mode with double factors combining software with hardware, which guarantees reliable bidirectional ID authentication to both server and user. Lastly, this paper has a non-formalization analysis to UBAP, it has proved that the protocol can resist the replay attack, server-impersonated, the snoop attack, the inserting channel attack, the middle-man attack and the brute-force attack.


We have demonstrated the feasibility of a high temperature cool-wall optical furnace that harnesses the unique power of concentrated solar heating for advanced materials processing and testing. Out small-scale test furnace achieved temperatures as high as 2400 C within a 10 mm X 0.44 mm cylindrical hot-zone. Optimum performance and efficiency resulted from an innovative two-stage optical design using a long-focal length, point-focus, conventional primary concentrator and a non-imaging secondary concentrator specifically designed for the cylindrical geometry of the target fiber. A scale-up analysis suggests that even higher temperatures can be achieved over hot zones large enough for practical commercial fiber post- processing and testing.


Reactions with dimethylcarbamoyl group transfer from N-acylpyridinium salts to pyridine N-oxides and from N-acyloxypyridinium salts to pyridines in acetonirile solutions were studied. Their rate and equilibrium constants and activation parameters were determined. The reactions were shown to be one-step and to follow the S N 2 mechanism. Equations relating the rate and equilibrium parameters of the N-O and O-N acyl transfer reactions to the basicity of the nucleophile and outgoing group were obtained.


Abstract. The results of the study of interspecific black currant hybrids are presented by the method of distant hybridization created in Central Yakutia. Six high-yielding, large-fruited and powdery mildew resistant Altai varieties were crossed with local varieties, which are based on the following currant species – R. dikuscha Fisch. ex Turcz, Ribes pausiflorum Turcz. ex Pojark. and R. procumbens Pall. to develop new adapted varieties. The aim of the research is to evaluate interspecific hybrids of black currant and promising forms to identify for the conditions of Central Yakutia. Objectives are to study the resistance of black currant hybrids to winter damage, powdery mildew and kidney mites; fruitful forms identify; the sources of positive signs and valuable promising forms highlight. Methods. The work was carried out in accordance with the program and methodology of variety study and selection of fruit, berry and nut crops. The hybrids were evaluated in the field against a natural background. Scientific novelty. New sources of economically valuable traits and promising hybrids for black currant breeding in Yakutia will be identified. Results. 13 sources of winter hardiness, 5 - yield were selected as a result of the study of black currant hybrids. A high yield of hybrids immune to powdery mildew was observed in 4 families, and to a kidney mite in 5 families. The selected sources of valuable traits and crossbreeding combinations will be further used in the work on black currants to create a new breeding material. The selected sources of economically valuable traits will be used in the future in the selection of black currants to create a new source material. Two promising forms of black currant distinguished themselves - 1-12-13 (Altayskaya pozdnyaya × Pamyati Kyndyla) and 2-9-13 (Podarok Kuzioru × Khara Kytalyk) according to the complex of features. They are of interest and will be studied for practical breeding.


Passively mode-locked fibre soliton lasers have become attractive as sources for laboratory and telecommunications applications due to their properties of simplicity, tunability, and subpicosecond operation. However, such lasers tend to suffer from instability in the repetition rate, which for many applications is unacceptable. Recently, though, stable harmonic passive mode-locking was observed in a ring laser configuration.1 In this paper, we present a detailed experimental study of time jitter in such a laser and demonstrate that a jitter as low as 600 fs can be obtained.


This introductory chapter provides the context for Cultures of Decolonisation by offering a theoretical framework for analysing the 'end of empire'. It sets out the value of using the lens of culture, broadly understood, to explore the processes of decolonisation. Here, we argue that cultural products and sites provide a productive arena for engaging with the complexities of decolonisation as lived beyond 'flag independence' and constitutional reform, and that object and spatial form are active agents in the discourses of independence, nationalism, decolonisation and neo-colonialism. Diverse cultures, shaped through and contributing to ideologies of modernism, development, internationalism, reframing notions of the universal and the specific, and engaging with questions of knowledge, epistemology and expertise, were crucial in the remaking of the geopolitical landscape in the mid-twentieth century. Material culture, social spaces, and creative arenas, from the museum to the internet chat room, Royal Mint and dictionary, are highlighted as sites for commentary and reflection, activism and articulation, and the celebration and negotiation of decolonisation. Having established the importance of image, object, text and practice in thinking through decolonisation, a series of claims about the nature of decolonisation are made: first, we argue for the need to redraw Eurocentric historiographies of decolonisation and highlight the activities and agency of decolonising and newly independent nations and individuals within and alongside analyses of metropolitan cultures of decolonisation. Second, we argue for the transnational and international nature of decolonisation, highlighting movements and networks – of people, ideas and things – between places and across borders, emphasising instances of solidarity and cross-fertilisation amongst individuals and communities, and the role that the cultural realm had in facilitating these exchanges beyond the high politics of empire. The role of the individual actor (working in tandem with the designed and natural world, and political and cultural frameworks) is particularly emphasised. In acknowledging the impact of the so-called periphery on decolonisation in this way, parallel assumptions about the origins of modernism and modernity are also contested. Finally, it is argued that we must pay attention to the shifting and non-linear temporalities of decolonisation. It is in the cultures of decolonisation that we can see more clearly the pre-histories, continuing legacies, resurgences, and contradictory trajectories of this phenomenon.


T he US Preventive Services Task Force (USPSTF) issued a recommendation of referring women at risk for perinatal depression to counseling. Perinatal depression affects 11.5% of mothers in the United States annually and is associated with short and long term risks to both mother and infant. Although the USPSTF had previously recommended screening for depression in all adults, including pregnant and postpartum women, the new recommendation focused on prevention instead of screening. To enact this advised change in approach, more research is needed to determine how to identify at-risk women, connect the identified women to effective treatments, and gage the outcomes of this new approach. Identifying women who have perinatal depression is straightforward utilizing self-rated scales collected in a clinical setting. It is more difficult to determine which women are at risk before the occurrence of perinatal depression because no accurate screening tool has been identified. The USPSTF concluded that studying a patient's history of depression, depressive symptoms, and sociodemographic features can help target women who should be referred to counseling. Future research should focus on developing a comprehensive screening tool as well as identifying biomarkers suggestive of vulnerability to perinatal depression. The optimal location for identifying at-risk women is where they receive care, due to the frequency of prenatal and postpartum visits. However, more resources are needed in this setting to devote needed time and energy for identifying at-risk patients and giving appropriate treatment recommendations. In addition, the shortage of professionals specializing in cognitive behavioral therapy and interpersonal psychotherapy makes needed care inaccessible to many women. It may be necessary to train lay personnel or utilize internet-based and smartphone-based platforms to ensure patients receive necessary care in a timely manner. Although the USPSTF found that counseling was an effective prevention for perinatal depression, there was a wide variety of counseling protocols included in the evidence report. Further research into the focus and duration of counseling sessions is needed to determine the optimal treatment program that would meet an at-risk patient's individual needs. After the conclusion of the recommended counseling, effectiveness studies must also be conducted to observe if subjects experienced favorable outcomes. In the case of women with more severe mental illnesses, systematic provisions for referral and treatment should be developed. In conclusion, the USPSTF's screening and referral recommendations have huge life-saving potential, but face many challenges for implementation. If today's health care systems can execute the recommended changes by overcoming the challenges of patient identification, sufficient treatment resources, and outcome analysis, there will be a significant improvement in the wellbeing of mothers and their children. Obstetric Anesthesia Digest Volume 39, Number 4, December 2019 Editorials and Reviews


Collecting quality data from software projects can be time-consuming and expensive. Hence, some researchers explore "unsupervised" approaches to quality prediction that does not require labelled data. An alternate technique is to use "supervised" approaches that learn models from project data labelled with, say, "defective" or "not-defective". Most researchers use these supervised models since, it is argued, they can exploit more knowledge of the projects. At FSE-16, Yang et al. reported startling results where unsupervised defect predictors outperformed supervised predictors for effort-aware just-in-time defect prediction. If confirmed, these results would lead to a dramatic simplification of a seemingly complex task (data mining) that is widely explored in the software engineering literature. This paper repeats and refutes those results as follows. (1) There is much variability in the efficacy of the Yang et al. predictors so even with their approach, some supervised data is required to prune weaker predictors away. (2) Their findings were grouped across N projects. When we repeat their analysis on a project-by-project basis, supervised predictors are seen to work better. Even though this paper rejects the specific conclusions of Yang et al., we still endorse their general goal. In our our experiments, supervised predictors did not perform outstandingly better than unsupervised ones for effort-aware just-in-time defect prediction. Hence, they may indeed be some combination of unsupervised learners to achieve comparable performance to supervised ones. We therefore encourage others to work in this promising area.