Smart sustainable cities represent a great challenge for the modern world. Generation Z (Gen Z), whose representatives are now entering adult life, will play a key role in the implementation of this concept. The purpose of this study is to investigate the nature of the relationship between the evaluation of smart mobility's importance for a smart city and the attitudes and behaviours of Generation Z members in the context of sustainability, use of ICT, and their declarative and actual participation in smart-city activities. The diagnostic survey method was used to achieve the research objective. The authors designed the questionnaire based on a literature analysis. The research sample consisted of 484 representatives of Generation Z—students of universities located in a smart city, Lublin (Poland). The collected data was statistically analysed using the following methods and statistical tests: Cronbach's alpha, Pearson's chi-square test for independence, symmetric measures: Cramer's V, and the contingency coefficient. The analysis of the obtained research results confirms that the conscious approach of Generation Z to sustainability has a significant and positive impact on their evaluation of actions taken in the field of smart mobility for a smart city. A similar relationship was confirmed with regard to the relationship between ICT use and smart-mobility evaluation. The significant and positive impact of young people's participation in smart cities on their evaluation of smart-mobility solutions' importance was not fully and unequivocally confirmed. In conclusion, the Generation Z representatives' awareness of the importance of sustainability and caring for the natural environment was confirmed by their desire to be pro-ecological in the areas of smart mobility studied in the paper. Moreover, young people who constantly use the latest technologies see their huge potential for the development of smart mobility in cities. However, despite the growing expectations of citizens' active attitudes and their increasing participation in smart-mobility development, it seems that the representatives of Generation Z are not really interested in it. Their declarations of willingness to join various opinion-forming and decision making processes do not actually transform them into active co-creators of smart-mobility solutions. Changing this approach can be an educational, organisational and technological challenge for smart-city authorities. The obtained research results could be used as guidelines for facilitating the search for innovative solutions in the area of smart mobility, improving the quality of life of smart-city residents based on the principle of sustainable development.


SUMMARY McDonald reported on the process the Memphis area library consortium is following in order to develop an RFP (Request for Proposal) to choose a new integrated library system. The consortium is required by state law to write an RFP for major purchases. The workshop focused on the basic organization needed to achieve their goals and concluded with a question and discussion period.


Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive impairment (aMCI) and 20 cognitively normal (CN) subjects completed resting‐state functional magnetic resonance imaging (R‐fMRI) scans. Multiple linear regression analysis was performed to test the main effects of the Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test delayed recall (RAVLT‐DR) scores, and their interaction on the intrinsic amygdala functional connectivity (AFC) network activity. Severer depressive symptoms and memory deficits were found in the aMCI group than in the CN group. Partial correlation analysis identified that the RAVLT‐DR scores were significantly correlated with the AFC network in the bilateral dorsolateral prefrontal cortex (DLPFC), dorsomedial and anterior prefrontal cortex, posterior cingulate cortex (PCC), middle occipital gyrus, right inferior parietal cortex, and left middle temporal gyrus (MTG). The GDS scores were positively correlated with the AFC network in the bilateral PCC and MTG, and left DLPFC. The interactive effects of the GDS and RAVLT‐DR scores on the AFC network were seen in the bilateral PCC, MTG, and left DLPFC. These findings not only supported that there were interactive neural links between depressive symptoms and memory functions in nondemented elderly at the system level, but also demonstrated that R‐fMRI has advantages in investigating the interactive nature of different neural networks involved in complex functions, such as emotion and cognition. Hum Brain Mapp , 2011. © 2011 Wiley‐Liss, Inc.


The rat sciatic nerve was transected mid-thigh and grafted with a silicone tube, the central 10 mm of which was filled with a collagen-glycosaminoglycan (CG) matrix. The rats were grafted contralaterally with empty silicone tubes as controls. The earliest compound muscle action potentials (CMAP's) at the plantar muscles were recorded around 11 weeks. After 30 weeks, the distal motor latencies recovered to about 50% higher than normal, the conduction velocity to about 50% normal, and the amplitudes of the CMAP's to about 50% normal. Of 7 rats in this study, all 7 nerves grafted with the CG matrix exhibited recovery, while only 1 grafted with the empty tube exhibited recovery. The CG matrix therefore appears to promote functional nerve regeneration across extended distances.


The influence of hafnium, yttrium and sulfur concentration on the oxidation resistance of single crystal, nickel base superalloys are compared at 1100°C in air. Both hafnium and yttrium improve oxidation resistance but the effects of yttrium are substantially greater than hafnium. Treatments to remove sulfur very significantly improve the oxidation resistance of superalloys. The effects of sulfur and oxygen active elements on superalloy oxidation resistance are examined.


A simple, specific, precise and accurate reversed phase liquid chromatographic (RP-LC) method has been developed for determination of insulin in dosage form. The chromatographic separation was achieved on a Symmetry® RP-C18, (150 × 4.6 mm, 5 μm) column at a detector wavelength of 214 nm and a flow rate of 1.0 ml/min. Mobile phase comprised of 55 volume of 1 mmol sodium sulphate in high performance liquid chromatographic (HPLC) water pH 3.2, adjusted by phosphoric acid and 45 volume of acetonitrile. The retention time of insulin was 4.3 min. The linear regression analysis data for the calibration plots showed good linear relationship in the concentration range between 1 and 45 µg/ml. The value of correlation coefficient, slope and intercept were, 0.9997, 67755 and 10773, respectively. Standard deviations of the slope and intercept for the calibration curves were 1824 and 17908, respectively. Limit of detection (LOD) and limit of quantitation (LOQ) values were determined to be 0.10 and 0.25 µg/ml, respectively. The method was validated for accuracy, precision and ruggedness. Mean recovery was 100.46%, while intra- and inter-day relative standard deviations were 0.395 and 0.289%, respectively. The proposed RP-LC method can be applied for the quality control or routine analysis of bulk insulin as well as commercially available formulations of insulin.

 Key words: Human insulin, isocratic, simple, rapid, high performance liquid chromatography (HPLC), pharmaceutical formulations.


The purpose of the present work is to study the bonding interactions between the substituents and the ring π system for a series of ortho and para MeₙH₃₋ₙM (M = C or Si, n = 0-3) substituted N,N-dimethylaniline . Both ground and excited-state interactions were studied and their magnitudes determined. The experimental data were then used in conjunction with molecular orbital calculations to differentiate among inductive, hyperconjugative, and d-pπ interactions on the ground and excited states. Overall, the study indicates that d orbital involvement in the interactions of organosilicon substituents with unsaturated systems is much less significant than is generally held. The importance of pₛᵢ⁻π and pₛᵢ⁻π* hyperconjugative interactions between silicon σ* orbitals and π system in producing the effects of silicon substitution on unsaturated systems has become more apparent.


In this letter we report active mode locking by means of a traveling acoustic wave in an arrangement with a diffraction acoustoopitic feedback. The active mode locking has een achieved in both linear and ring cw YAG:Nd/sup 3 +/ lasers. (AIP)


It can be stated that the state has turned to the non-financial functions of taxation with the tax expenditure practices, with the abandonment of This work is licensed under Creative Commons Attribution-NonCommercial 4.0 International License Türkiye'de Vergi Harcamalarının Vergilendirmenin Fonksiyonları Açısından Değerlendirilmesi: 2019-2023 140 Maliye Çalışmaları Dergisi Journal of Public Finance Studies a part of the current period tax collection. Purpose of tax expenditures can be explained by the aim of improving macroeconomic indicators such as economic growth, economic stability, efficiency in resource distribution and ensuring fair income distribution. Tax expenditures are generally incurred as tax exemptions, tax exemptions and tax deductions in tax practices. The tax system within the tax expenditure, size of the system and it is important for distribution as tax types in Turkey. The state forgoes tax receivables in the short term and leaves the collection of tax receivables to the long term, with the tax expenditure practices. It focuses on the economic and social objectives of taxation in the short term. Especially with the improvement of macroeconomic indicators, more tax revenues will be collected in the long term. This study aims to include the financial period 2019 to 2023 of tax expenditures in Turkey is evaluated using a variety of indicators and economic size in terms of the functions of taxation. Analyzes were made using the descriptive model, one of the qualitative research methods, and the documentation analysis technique, one of the research techniques. As a result of the study Turkey's 2023 targets for moving towards that in this process it was concluded that income tax is a direct tax and corporate entities located in tax expenditure item in the tax to determine a plan of effectively used as a fiscal tool.


This study investigated preservice teachers" content knowledge involving fractions operations and their beliefs about problem-solving. Preservice teachers took a semester of instruction on problem-solving that emphasized the use of multiple representations and solutions, communication of mathematical ideas, and working collaboratively. Common misconceptions were discussed and preservice teachers" beliefs about teaching mathematics were presented. Findings support initiatives to improve preservice teachers" content knowledge and beliefs in teaching and learning with understanding.


The oxide thickness is of great concern today. The basic idea is to grow SiO2 layer on Silicon. The oxide is grown on intrinsic silicon substrate by thermal oxidation i.e., wet oxidation and dry oxidation. The thickness is compared for both the oxidation processes after different oxidation cycles. The capacitance per unit length is also calculated for the oxide growth in above. The percentage oxide thickness is also estimated and the oxide is found to grow more into the substrate with time and number of cycles.


A door locking system for a freight or passenger elevator or goods lift installation having vertically spaced landings served by a vertically movable car, the landings and car each being protected by associated horizontal slide doors, a mechanical interlock device at each landing that prevents a landing door from opening without the presence of the car in registration with the landing, a door lock on the car for normally preventing the car door from opening when the car is out of registration with any landing, the interlock device being arranged to mechanically enable the door lock to release the car door to open when the car is in registration with a landing.


Ubiquitin /26S proteasome pathway( UPP) is the most effective,highly selective proteolytic pathway. It mediates 80% to 85% of the protein degradation in eukaryotic cell,participates in various cellular life courses,and plays an important role in maintaining the normal physiological function of the cells. The results show that many aspects of plant growth and development as well as some processes such as drought stress response are all affected by this pathway. It summarizes ubiquitin /26S proteasome pathway,which roles in the processes of plant growth and development,and emphatically elaborates the progress of the plant drought stress response and its mechanism mediated by the ubiquitin-protein ligase E3.


Proving the security of complex protocols is a crucial and very challenging task. A widely used approach for reasoning about such protocols in a modular way is universal composability. Several models for this approach exist, including the UC, GNUC, and IITM models. Despite the wide spread use of the universal composability approach, none of the existing models are fully satisfying. They all lack either soundness, flexibility, or usability. As a result, proofs in the literature are very often formally incorrect, protocols cannot be modeled faithfully, and/or using these models is a burden rather than a help. Given this dire state of affairs, the goal of this work is to provide a framework for universal composability which combines soundness, flexibility, and usability. Developing such a security framework is a very difficult and delicate task, as the long history of frameworks for universal composability shows. As the IITM model appears to be closest to this goal in terms of soundness and flexibility, we build our framework, called iUC, on top of the IITM model. At the core of iUC is a single simple template for specifying essentially arbitrary protocols in a convenient, formally precise, and flexible way, which allows protocol designers to concentrate on the core logic of a protocol. We illustrate the main features of our framework with example functionalities and realizations.


Soil compaction in experimental sugar cane increased the bulk density from 1,3 to 1,4 g.cm-3, the resistance of 2665,2 to 4515,2 kPa and it diminished the porosity from 51,9 to 48,2%. At 11 months the compacted non-cultivated soil treatment (CNC) reduced bulk density by 5,7%, the resistance by 31,4% and the total porosity increased by 2,3%, attributable to the capacity resilient of the soil. The treatment compacted-cultivated (CC) diminished the bulk density by 7,9%, the resistance by 47,6% and the total porosity increased by 3,5%. The amplitude of the optimum water interval (OWI) was reduced at CNC compared with CC treatment, with a critical bulk density of 1,28 g.cm-3 y 1,36 g.cm-3, respectively.


The lower Miocene Galoc clastic unit, offshore Palawan, Philippines, is about 500-600 ft thick. The unit overlies the Galoc Limestone and is overlain by the Pelitic Pagasa Formation. The Galoc clastic unit consists of alternating quartzose sandstone, mudstone, and resedimented carbonate deposited at bathyal depths, mainly as turbidites. The deep-water deposits are confined to the axis of a northeast-trending trough in which slope, submarine channel, interchannel, depositional lobe, slump, and basinal facies are recognized. Eroded shallow-marine carbonate lithoclasts are commonly incorporated within the siliciclastic turbidites. The main reservoir sandstones occur in submarine channels and depositional lobes. The sandstones are texturally submature, very fine to medium-grained feldspathic litharenites and subarkoses. The sandstones have detrital modes of Q78:F11:L11 and Qm51:F11:Lt38, with partial modes of the monocrystalline components of Qm82:P13:K5. Lithic fragments include chert, shale, schist, volcanic rock fragments, and minor plutonic rock fragments. Porosity in the better reservoir sandstones ranges from 11 to 25%, and calcite is the dominant cement. Dissolution textures and inhomogeneity of calcite distribution suggest that at least half of the porosity in the sandstones has formed through the leaching of calcite cement and labile framework grains. A source terrain of quartzo-feldspathic sediments and metasediments, chert, volcanics, and acid-intermediatemore » plutonic rocks is visualized.« less


A procedure is described for the digital processing of fibre diffraction patterns to yield a quasi-continuous map representing a central section through the cylindrically averaged intensity transform of the specimen. No assumptions are required about the nature of the specimen other than that it has fibre-type symmetry. The specimen intensity transform can be used to obtain integrated intensities for discrete reflections from microcrystalline fibres that are potentially as accurate as those obtained from crystals. Improved procedures for extracting structure amplitudes from specimens with continuous layer lines are also described.


Introduction: Sites of complex fractionated atrial electrograms (CFAE) with a short mean cycle length (MCL) and sites with a high dominant frequency (DF) have been advocated as targets for ablation in patients with persistent atrial fibrillation (AF). However, there are little data on the relationship between theses 2 markers. This study assessed the relationship between the DF and electrogram MCL after pulmonary vein (PV) isolation in patients with persistent AF.


Abstract Mixed-frequency Vector AutoRegressions (MF-VAR) model the dynamics between variables recorded at different frequencies. However, as the number of series and high-frequency observations per low-frequency period grow, MF-VARs suffer from the "curse of dimensionality." We curb this curse through a regularizer that permits hierarchical sparsity patterns by prioritizing the inclusion of coefficients according to the recency of the information they contain. Additionally, we investigate the presence of nowcasting relations by sparsely estimating the MF-VAR error covariance matrix. We study predictive Granger causality relations in a MF-VAR for the U.S. economy and construct a coincident indicator of GDP growth. Supplementary materials for this article are available online.


Abstract:This article considers the important interdisciplinary contributions of Karen Barad's "Transmaterialities: Trans*/Matter/Realities and Queer Political Imaginings" (2015). Barad adopted Mary Shelley's Frankenstein as a metaphor to examine concepts of agency, empowerment, and self-birth, in ways that challenged long-established notions of queer identities and scholarship. The present article adopts the trope of lightning strikes to consider the ways that Barad's Frankenstein-esque approach has reshaped and extended scholars' approaches to queer theories and methodologies across a range of disciplines.


The general integral of a class of three dimensional generalized Lotka Volterra systems is discussed. Basing on a new kind of transformation of variables, several groups of integrable conditions and the corresponding first integrals are obtained.


The effects of oil-water mixed frying (OWF) and pure-oil frying (POF) on changes in quality characteristics of soybean oil and chicken chop during six days of frying were comparatively investigated. The results showed that the changes in specific extinction coefficients, p-anisidine value, carbonyl value, viscosity and color of soybean oil were more pronounced in the case of POF, indicating that oil oxidative and polymeric degradation was retarded by OWF. Concerning fat content of chicken chop, lower (p<0.05) values were observed in the last three days in the case of OWF than POF. Meanwhile, OWF led to lower acrylamide formation in chops during the six days. Sensory evaluation showed that OWF provided chops with five attributes similar to those of chops fried by POF on the first day. As frying days increased, the decreases in scores for color, odor, flavor and overall acceptability were less in the case of OWF. In conclusion, OWF could be a worthwhile alternative for retarding oil deterioration and producing healthier and higher quality fried meat products.


Adriamycin (ADM) inhibited the beating of cultured mouse embryo myocardial cells dose-and time-dependently and subsequently lysed the cells. Fifty percent inhibition of beating cell number was observed when cultures were exposed to 430-520 μm ADM for 0.5h, 70-100 μm ADM for 4h and 3.5 μm for 36 h. When cultures were exposed to 3.5μm 3H-ADM, the radioactivity in the cells reached almost the maximum within 8 h, and about 90% was recovered as ADM itself even after 72 h. However, the beating cell number and the beating rate did not appreciably decrease within 8 h, then decreased to 78.5 and 67.1% at 24 h, and 5.6 and 5.2% at 72 h, respectively. Lysis of the cells was conspicuous at 48 h or later. It was also supported with the decrease in cellular proteins and the release of lactate dehydrogenase. These results indicate that ADM stimulates lysis of the cytoplasmic membrane following inhibition of beating. When cultures were exposed to 70 μm ADM for 4 h and then incubated in ADM-free medium, about 50% of ADM in cells was released within 24 h. However, inhibition of beating and lysis of such cells still advanced at about the same rate as in continuously exposed cells. ADM also decreased the cellular adenosine triphosphate (ATP) content in the same fashion as antimycin A, which inhibited beating in advance of ATP reduction. These results suggested that the beating state of myocardial cells is a sensitive and reliable parameter in this system for studies on the cardiotoxicity of ADM. The system may be useful for studies not only on ADM but also on agents having effects on the heart.


This paper proposes a mathematical approach to the analysis of disassemblability of a product for generating stable robotic assembly sequences. The disassemblability of a part, which represents a cost for disassembling the part from a base assembly, is derived in terms of both separability of a part from a base assembly and motion instability of the base assembly. Then, stable robotic assembly sequences are found in the list of parts, each of which is sequentially chosen to have a locally maximum disassemblability. To show the effectiveness of the proposed method, case studies are presented for industrial products. The results are compared with those of previous researches. The comparison shows that the proposed method can effectively generate stable robotic assembly sequences and provide essential informations on fixture design.


The author classifies the areas round the rail transportation station into that of public center, transportation hinge, mature residence center, and urban periphery, summarizes the characteristic and problem of this areas, predicts their development trend, and brings forward the specific measure of the planning and construction of these areas.


A 19‐year‐old woman presented with photophobia, pain in the eyes and diminishing vision for 12 years, intermittent fever associated with headache, giddiness, and nausea for 8 years, and depigmented macular lesions bilaterally around the eyes for 8 years. Examination revealed mild exophthalmos, poliosis of the eyelashes, depigmented macules over the bilateral upper and lower eyelids ( Fig. 1 ), and loss of hair over the scalp. An ophthalmologic evaluation revealed circumcorneal congestion in the eyes with fine pigmented keratotic precipitates and irregular pupils, suggesting iridocyclitis. The right eye showed vitreous opacities. Vision was 6/36 on either side and the intraocular pressure was 10 mmHg and 12 mmHg on the left and right eyes, respectively. Examinations of other areas of the body and other systems, including the nervous system, were within normal limits.


The book abounds in minor deficiencies: errors of omission (infectious mononucleosis is missing); errors of commission (the demonstrably and notoriously inaccurate indirect platelet counting method is employed and touted as the preferred method); and syntactical problems—"Hemosiderosis, another major disorder related to the presence of excessive iron deposits, is that found in certain anemias." The book's major deficiencies involve certain attitudes regarding therapy. To judge from his recommendations and performance Hall is convinced that corticosteroid is relatively harmless stuff. For the treatment of idiopathic thrombocytopenic purpura he proposes that "one may wish to recommend this regime indefinitely." He presents an exemplary case of child in whom thrombocytopenia developed following rubella. Pediatric hematologists have learned that it is safe, and therefore advisable, to give no medication for this self-limited disorder. Hall prescribed prednisone. After one week the child's platelet count had returned to normal (800,000 indirect), but steroid therapy was continued for


Introduction In 1874 Japan"s first machine-made paper was produced. Its history of 130 years is shorter than those in European countries. However, the Japanese paper industry grew rapidly in the 20th century, and Japan has remained the second largest paper producer in the world for almost 30 years after 1973. Though it was overtaken by others afterwards, Japan"s paper and paperboard production was still ranked third in the world (31.22 million tons annually), pulp production seventh (10.8 million tons), and its per capita paper consumption was eighth (247.4 kg) in 2007, as one of the top producers and consumers of paper.2 Though it set out the last among the major papermaking countries in the 20th century, Japan grew the fastest (Graph 1 and 2). The growth was supported by the rapid expansion of its domestic market. Unlike other implanted industries, import dependency was low from the outset. Foreign manufactures operating in Japan were virtually non-existent. The fact that a system in which domestic manufacturers cater to most of the domestic


Sericin films which have good mechanical property were prepared by using epoxides as cross-linking agent. The structures of modified membranes were characterized by X-ray diffraction, The dissolubility in water and the mechanical properties were measured. The effect of the cross-linking agent on the sericin's physical property and structure was discussed. The results indicated that the cross-linking agent had notable cross-linking effection,it changed crystal structure of sericin and improved the physical and mechanical property of sericin films, the film which added about 30% PEGO10 had better tensile strength and elongation at break.


The strengthening of national institutions is crucial to the success of the Rome Statute system. Given the recent emphasis on obtaining ratification of the Rome Statute in the Pacific, this article argues that the ratification and implementation process should include a review of the domestic criminal law in Pacific Islands countries in order to ensure that the crimes penalised by the ICC implementing legislation and the domestic law are in harmony. In addition, the rules of evidence and procedure should be amended so that they are in keeping with international norms of justice. Further, training of justice sector personnel is necessary in order to ensure that biases that affect the investigation, prosecution and hearing of gender and sexual violence crimes are addressed.


Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible synthetic polymers with structures mimicking natural proteins. These polymers exhibit reversible secondary conformation transitions and/or hydrophilic–hydrophobic transitions in response to changes in environmental conditions such as pH and temperature. The stimuli‐triggered conformation and/or phase transitions lead to unique self‐assembly behaviors, making these materials interesting for controlled drug and gene delivery applications. Therefore, stimuli‐sensitive synthetic polypeptide‐based materials have been extensively investigatid in recent years. Various polypeptide‐based materials, including micelles, vesicles, nanogels, and hydrogels, have been developed and tested for drug‐ and gene‐delivery applications. In addition, the presence of reactive side groups in some polypeptides facilitates the incorporation of various functional moieties to the polypeptides. This Review focuses on recent advances in stimuli‐sensitive polypeptide‐based materials that have been designed and evaluated for drug and gene delivery applications. In addition, recent developments in the preparation of stimuli‐sensitive functionalized polypeptides are discussed.


In the past, from a signal processing perspective, most wireless networks have been Single Input and Single Output (SISO), with the sequential nature of SISO signal processing serving as a bottleneck that limits performance. However, processing multiple signals simultaneously through smart antennas could lead to substantial performance improvement. Using this new approach, researchers are exploring Multiple Input and Multiple Output (MIMO) wireless technologies to improve end-to-end network throughput of multiple flows relative to SISO antennas. This proposal investigates the impact of smart antennas on a wireless ad hoc network.


Objective:To investigate the epidemic of meticill-resistant staphy lococcus aureus(MRSA)in intensive care unit(ICU),analyse the risk factors and its countermea sures.The ways to prevent and treat this nosocomial infection.Methods:The case histories from 10 in patients and environment of hospital who developed MRSA infection in ICU form Mar.7 to Mar.29,2008,were studied retrospectively to find out the reason of the epidemia and its countermea sures.Results:The rate of MRSA infection was 47.6% in ICU.MRSA could be found the air,hands of accompanying persons,healthy careworker et al.the MRSA spectrum cultured from is treatment based on the sputum culture results was in accordance with that in its environment.Conclusion:The MRSA infection was fulminate epiidemiological at a certain ward intensifying environmental,nursing,airy monitoring inside and outside ICU,avoiding across infection,adopting aseptic courses in invasive procedures and keeping good utilization principles for antimicrobial drugs,decline nosocomial infection of the MRSA in ICU.


The generation of wavelength-tunable dispersive waves in tapered optical fibers is modeled. The pump source is taken to be a femtosecond laser with emission wavelength at 1030 nm, which is appropriate for an Yb-based fiber laser and variable pulse energy and duration. The variable pulse properties translate into wavelength tunability of the dispersive waves across the visible spectrum due to the fiber tapering. This contribution investigates taper design strategies to obtain features such as spectral isolation of the visible output, low-noise operation with optimal spectral density, and short output pulses.


The research progress of the welding residual stress at home and abroad is summarized by the research methods and the means of the residual stress.The development and the problems to be solved are thoroughly discussed,so as to provide the direction for the optimal design of the stability of engineering structures.


UM-BUS is a novel dynamically reconfigurable high-speed serial bus for embedded systems. It can achieve fault tolerance by detecting the channel status in real time and reconfigure dynamically at run-time. The bus supports direct interconnections between up to eight master nodes and multiple slave nodes. In order to solve the time synchronization problem among master nodes, this paper proposes a novel time synchronization method, which can meet the requirement of time precision in UM-BUS. In this proposed method, time is firstly broadcasted through time broadcast packets. Then, the transmission delay and time deviations via three handshakes during link self-checking and channel detection can be worked out referring to the IEEE 1588 protocol. Thereby, each node calibrates its own time according to the broadcasted time. The proposed method has been proved to meet the requirement of real-time time synchronization. The experimental results show that the synchronous precision can achieve a bias less than 20 ns.


This assignment proposes an integral project that consists in the redesign and readjudment of a heritage house located in Latacunga city, which requires an inmediate intervention to conserve the original architecture of the republican era. The purpose of this project consists to revive the characteristics of republican life, to generate a fusion between XIX century and todays architecture. It's considered three main spaces: A coffee library, art galleries and a lodging area, whose common objective is to generate experience to national and international visitors. The interventions are made based on the concept of the fabric worked on the Jacquard loom and highlight in each space the original materials of the building, such as pumice stone and woodwork. Vegetation plays an important role that integrates interior and exterior spaces, which will be functional and aesthetically pleasing for young people and adults with an interest in culture. It handles a chromatic given especially by the colors of stone, wood and vegetation that provide warmth and harmony to the space, contrasted with primary colors to give a touch of joviality, and neutral colors such as black and white to evoke a sophisticated atmosphere. In this way an important architectural piece of the historical center will be conserved and additionally it will contribute to the culture and tourism of Latacunga city.


We compared patient-controlled epidural analgesia (PCEA) with patient-controlled intravenous analgesia (PCIA) using pethidine or fentanyl in a randomized, double-blind crossover study of 80 patients after caesarean section. Patients received pethidine by PCEA or PCIA, or fentanyl by PCEA or PCIA, with a crossover of the route of administration at 12h. For pethidine, pain scores were lower with PCEA vs PCIA from 4 to 16 h (P<0.05). Pethidine consumption was lower with PCEA vs PCIA from 12 to 24 h (P=0.0005). Patients preferred PCEA to PCIA (P=0.015). For fentanyl, pain scores were lower with PCEA vs PCIA at 12 h (P=0.045). Fentanyl consumption was lower with PCEA vs PCIA from 0 to 12 h (P=0.0007). Patients had similar preference for PCEA and PCIA. Pain scores and side-effects were similar between drugs. Plasma pethidine was similar between groups. Plasma fentanyl was higher with PCIA vs PCEA at 12 h (P=0.002). PCEA has advantages over PCIA and pethidine may be the preferred drug.


To determine the readiness of the company in applying the design thinking process, a measurement is needed. Thus, the company's leadership does not encounter problems in applying design thinking. The research method is based on the framework from Dunne, Eriksson and, Kietzmann on the analysis of company readiness in applying design thinking (DT). The readiness aspect is divided into eight dimensions, namely: goals, collaboration, work style, thought processes, knowledge generation, constraints, failures, and workflow. These eight dimensions are measures in the design thinking readiness matrix which are divided into four quadrants, namely: not ready for DT, ready to encourage DT, ready to fight DT's frustrations, ready to adopt DT. The research was conducted at PT. XYZ to assess readiness to apply DT. The results of this study indicate that PT. XYZ is moving towards the readiness stage to encourage DT. Therefore the leadership of PT. XYZ needs to strengthen the perceptions of managers and employees about design thinking in the company.


Objective Immune-mediated inflammatory disease (IMID) is associated with an increased risk of mortality. It is unclear whether the higher mortality is attributable to the IMIDs themselves or to the higher prevalence of comorbidities in IMIDs. We aimed to investigate whether IMIDs per se confer a higher risk of mortality. Methods From the Korean National Health Insurance Service-National Sample Cohort database, this population-based cohort study included 25,736 patients newly diagnosed with IMIDs between January 2007 and December 2017, and 128,680 individuals without IMIDs who were matched for age, sex, income, hypertension, type 2 diabetes, dyslipidemia, and the Charlson comorbidity index. All individuals were retrospectively observed through December 31, 2019. The outcomes included all-cause and cause-specific mortalities. Adjustments for age, sex, and comorbidities were performed using multivariable Cox proportional hazard regression analyses, and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for the outcomes were estimated. Results The adjusted risk of all-cause mortality was significantly lower in patients with IMIDs than that in those without (aHR, 0.890; 95% CI, 0.841–0.942). Regarding cause-specific mortality, cancer-specific (aHR, 0.788; 95% CI, 0.712–0.872) and cardiovascular disease-specific (aHR, 0.798; 95% CI, 0.701–0.908) mortalities were the two causes of death that showed significantly lower risks in patients with IMIDs. A similar trend was observed when organ based IMIDs were analyzed separately (i.e., gut, joint, and skin IMIDs). Conclusion After adjusting for comorbidities, IMIDs were associated with a lower risk of all-cause mortality compared to those without IMIDs. This was attributable to the lower risks of cancer-and cardiovascular disease-specific mortalities.


If psychoanalytic psychotherapy is to be part of the undergraduate medical curriculum, it must be well taught, and demonstrably relevant to the training of doctors. Psychotherapy teachers have a responsibility to devise a syllabus which is clear and relevant and to provide teaching which stimulates and engages the students so that they learn by thinking and understanding. An outline of a syllabus for medical students is included and one seminar as an illustration of interactive learning is described.


In this paper, we study the dynamics of the atomic inversion, scaled atomic Wehrl entropy and marginal atomic Q-function for a single two-level atom interacting with SU(1,1) quantum system. We obtain the wave function and system density matrix using specific initial conditions. We examine the effects of different parameter s on the scaled atomic Wehrl entropy, atomic Q-function and their marginal distribution. We observe an interesting monotonic relation between the different physical quantities for different values of the initial atomic position and detuning parameter


The Technion is Israel's oldest institution of higher learning. Its origins date back to the years of pre‐World War I. To 1912 to be exact. But, due to the outbreak of hostilities it begun to function only in 1924. Some years had to pass before it got over its birth pangs. Its infancy led to moderate accomplishments compared to the present fame. The Technion stands to‐day on 300 acres of wooded land. Its campus on Mount Carmel is one of the most beautiful in the world. A city within a city the Technion comprises some forty impressive, modern buildings that blend into their landscaped setting. It took the newly founded College for Higher Education, which is in the Negev, under its wings, and the young Haifa University is affiliated with the Technion. Academically, it is being compared to the Massachusetts Institute of Technology. Not only for being a Technical University but for the superior qualifications demanded from its teaching staff and the high standard expected from its students.


Mustafa Kamal abolished the institution of Khilafat in 1924, but the Sargodha district Khilafat Committee continued its functioning. Peers of Sial Sharif and Bugvis of Bhera played the leading role, while pro-British feudal lords supported the government. Khilafat conferences were held in which high-level Khilafat leaders participated and addressed. Samarna-Fund was collected, and a sum of Rs 9600 was submitted to the Punjab Khilafat Committee. Sialvi and Bugvi visited different towns and villages and conveyed the Khilafat message in simple words. Bugvi was arrested and sent to prison for one and a half year. While on the arrest of Peer of Sial-Sharif, the Muslims of Soon Valley began to offer arrest every day. From the Khilafat movement, Muslims of Sargodha enhanced their awareness and gained experience. They utilized it in Pakistan Movement 1940-47 and received prominent status in any district of Punjab outside Lahore. They challenged their feudal lords of past and rulers of present and, as a powerful factor, won their share in freedom.


The sine-squared potential is introduce to describe the interaction between particles and the crystal.The motion equation of the planar channelling particles is reduced to the pendulum equatione by this interaction potential.The solution of the equation and the period of the particle motion are expressed exactly by means of Jacobian elliptic function and elliptic integral.The radiation intensity and properties of the radiation spectrum are discussed.It is point out that it is possible to take channeling radiation as a new γ-Laser.


The utility model discloses an adjustable movable type worktable and belongs to a universal detection platform. The device comprises a five-dimensional worktable and further comprises a three-foot base, wherein the three-foot base comprises a mounting plate, a cylinder, a hoisting handle and a base; the five-dimensional worktable is mounted on the mounting plate through a bolt; a piston rod is arranged on the bottom face of the mounting plate; the piston rod is sleeved in the cylinder; the piston rod is provided with a gear rack pair; a hoisting handle controls the piston rod by the gear rack pair to move up and down in the cylinder; and the base is fixedly arranged at the bottom of the cylinder. The worktable can move at any time and the height and the angle can be accurately adjusted.


Between 1970 and 2004, there has been a 55% reduction in road fatalities per capita in countries of the Organization for Economic Cooperation and Development (OECD). However, over the same period, motorcyclist fatalities per capita only decreased 44%. The number of motorcyclist fatalities accounted for an increasing proportion of all road users killed in Greece (+97%), Luxembourg (+25%) and the United States (+25%). Most studies have attributed the motorcycle safety problem to inexperience and unlicensed riders, riding under the influence of drugs or alcohol, bad riding behavior and poor motorcycle maintenance. This paper analyses the effect of improvements in medical care and technology in reducing motorcyclist fatalities. Data from the International Road and Traffic Accident Database (IRTAD) and OECD health care data for 1970 to 2004 were used. A fixed effects Negative Binomial model is developed to examine the effect of improvements in medical care and technology. Three proxies of medical care and technology changes are considered. These are average length of inpatient stay in the hospital, physicians per capita and infant mortality rate. Results find that all these proxy variables are significant with the expected sign suggesting that improvements in medical care and technology have contributed to reduced motorcyclist fatalities. The results also reveal that increases in gross domestic product (GDP) per capita, motorcycles and non-motorcycle vehicles per capita are correlated with high motorcyclist fatalities. On the other hand, increases in the population aged 25-64 years appears to be associated with decreases in motorcyclist fatalities.


There has been a tremendous growth in the adoption of Peer-to-Peer (P2P) systems for media distribution and file sharing. However, P2P is now also being used as underlying technology for other purposes such as the distribution of software updates or as infrastructure for a distributed information repository. The research introduced in this paper is motivated by a use case in the latter area. This use case addresses the problem of document and information sharing between educational institutions in Malaysia. The additional challenge is that apart from not having any central instance peers have regular, daily down-times. During the night all peers disappear altogether. Hence the challenge is to find an effective way to set-up a P2P information and document sharing system taking into account the special characteristic of the dis- and re-appearing peers. In this paper, we investigate various bootstrapping architectures for the proposed Scalable Private Reappearing Overlay Network (SPRON). The bootstrapping needs to be self-organize, scalable and handle deterministic churn rate during its network formation period for peers (or computers) in various operational levels of the ministry of education. The deterministic churn rate is defined as the continuous process of node arrival and departure pattern of a P2P system. Within this paper we present the background information of the research theme, problem statements, and a proposed Scalable Private Reappearing Overlay Network (SPRON) design to illustrate a specialized P2P network and its unique set of requirements. The main focus of the paper is the presentation of the finding of our investigation regarding the bootstrapping performance of Chord, Chord with Aggressive Join, and Kademlia in order to establish the most appropriate P2P structure to base our system on. Through this we determine the suitability of these structured networks as the foundation in the proposed Scalable Private Reappearing Overlay Network design.


T THE simultaneous appearance of a constitutional anniversary and of a new book on recent American political thought' furnishes an excuse for discussing once more the dependence of Americans upon the political thinking of their sesquicentennial ancestors. During one short generation, from about I76i to I788, there was a flowering of political theory in this country which has not often been equaled and very rarely surpassed in any comparable period. The controversial literature of the time occupies a position of hardly less importance than the literature of the English civil wars, upon which it so heavily drew. The institutional products, and especially the written constitutions, have not only continued to serve as patterns here but they have also been widely imitated-in France, in the British Empire, in Latin America, and even in post-war Europe. Nor did the age fail to produce its great political treatise, for the Federalist is a far more significant work on politics than many a book more generally studied from that point of view. It has suffered from 'an excess of oratorical praise and an almost total absence of analysis. To most students of American history it is simply the longest argument in favor of the ratification of the Constitution, and the depth and originality of its theoretical analysis is rarely considered. Even the famous No. IO is well known only for a paragraph or so which, wrested out of its context, gives aid and comfort to the exponents of the economic interpretation of history. Because to an extent unparalleled among modern peoples we have been living upon the ideas of our forebears we have at least had a relatively stable political tradition. Changes there have been-in constitutional institutions and in ideas about them-but the changes have been in terms of the ideas of the founding-fathers. There is no safety in prophecy, but at present it appears that for a long time to come further changes will be in those same terms. I shall have more to say on the subject later in this essay, but it may be remarked in passing that this traditionalism is certainly one of the main reasons why the Marxian philosophy has had so little success in this country. This political tradition is not to be defined by the use of a single word. Not democratic, nor revolutionary, nor conservative, nor constitutional,


Francisella tularensis is the causative agent of the infectious disease tularemia and is designated a category A bioterrorism agent. The type VI secretion system encoded by the Francisella pathogenicity island (FPI) is necessary for intracellular growth; however, the functions of FPI proteins are largely unknown. In this study, we found that the FPI protein intracellular growth locus E (IglE) showed a unique localization pattern compared to other FPI proteins. Deleting iglE from Francisella tularensis subsp. novicida (F. novicida) decreased intracellular growth. Immunoprecipitation and pull‐down assays revealed that IglE was associated with β‐tubulin. Additionally, GFP‐fused IglE colocalized with microtubule organizing centers (MTOCs) in 293T cells. The iglE deletion mutant was transferred with dynein toward MTOCs and packed into lysosome‐localizing areas. Conversely, the wild‐type F. novicida exhibited intracellular growth distant from MTOCs. In addition, IglE expressed in 293T cells colocalized with dynein. These results suggest that IglE helps to prevent dynein‐ and MTOC‐mediated intracellular trafficking in host cells to inhibit the transport of F. novicida toward lysosomes.


Disclosed is a method for exposing an electron beam of a beam-shaping type, wherein the electron beam can be shaped into polygon having desired size by passing through a first and a second apertures. The position of the first or the second aperture tends to be deviated from its design position due to heat, resulting in a deviation of the electron beam. According to the invention, the offset value of the real image formed on the second aperture, with respect to the ideal image, is automatically determined by detecting a current passing through the second aperture. During an electron-beam exposure for patterning, the amount of deflection of the electron beam is corrected by taking the previously obtained offset value into consideration.


A new initiating explosive-tetraamminediazido cobalt(Ⅲ) perchlorate(DACP) was synthesized.Its structure was characterized by the IR,()~1HNMR etc.And the main properties were measured by the various methods.The results show that DACP is an excellent primary explosive similar to tetraamminebis(5-nitrotetrazolato) cobalt(Ⅲ) perchlorate(BNCP) in functions.Synthetic method of DACP is much simpler than that of BNCP.In some initiating devices,DACP may be a substitute for BNCP and(Pb(N_3)_2).


+*Melrose, J (A-NHMRC); *Smith, S (A-NHMRC); **Little, C (A-The University of Wales); *Kitson, J (E-The Royal North Shore Hospital); *Hwa, S (A-Taiwanese Government); *Ghosh, P (E-University of Sydney) +*The Institute of Bone and Joint Research, The University of Sydney and Royal North Shore Hospital, St. Leonards, NSW 2065, Australia.. The Institute of Bone and Joint Research, Level 5, University Clinic, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia., 612-9926-7395, Fax: 612-9926-6539, email@example.com


Calculations are presented involving the scattering of low energy4 He atoms from LiF(001), and compared with experiment. Resonant scattering theory is briefly reviewed, and a prescription for determining the shapes and signatures of resonant features is presented. Inelastic effects are included by means of a Debye—Waller scaling.


The purpose of this paper is to scrutinize the situation of the reception of unaccompanied children in Sweden and whether they get their rights satisfied during the asylum process. To see the phenomenon through different aspects the paper consists of legal, political and psychological perspective. In the search of an answer to my questions a description about how Swedish authorities working with unaccompanied children follow international and national laws and guidelines regarding the children will be outlined. The political unwillingness in the Swedish municipalities to receive unaccompanied children and its effects on the children is then to be followed. My conclusions are that it is hard for Sweden to live up to all of those laws and guidelines concerning unaccompanied children. This is partly due to the political unwillingness that exists in the municipalities. The consequences of this are that the children don't get all of their rights satisfied and many of the children have a psychological ill-health, which affects them negatively. (Less)


Clustering has been a powerful tool to visualize complex data with extensive applica- tions in many disciplines. In this paper, we propose an optimization-based solution to the fuzzy binary clustering problem by grouping all the data points into two clusters. Our model are based on two assumptions. One is that the similar objects are labeled similarly, which is known as the "cluster assumption" in semi-supervised learning. The other assumption is that the most dissimilar two objects belong to different clusters. The problem is formulated as a quadratic programming model and can seek the optimal fuzzy labels for the objects. Our model can be solved efficiently by designing a fast algorithm. In addition, it can be reformulated as a linear programming solved efficiently if the similarity matrix is sparse. Furthermore, this model can then be extended to explore the hard-binary-clustering and multiple-clustering problems by a few modifications. Experiments on both simulated and real data sets demonstrate the effectiveness of our method.


The present invention relates to an OFDM system multiservice multimedia transmission, receiving method and apparatus, transmission method comprising: the quality of service requirements of traffic to be transmitted, determine the basic frame structure comprising OFDM determining length and position data block, and when transmitting data symbols to be mapped to each service corresponding; resource sub-layer sheet when physically divided frequency; respectively different business data stream preprocessing symbols to obtain data to be transmitted; frequency resource allocation when each service respectively frequency resource; indicate the basic transmission parameters of an OFDM system in the signaling, the coding and modulation scheme for all operations and the time-frequency resource position; signaling, OFDM data block of the digital baseband signal; the digital baseband signal is processed, then through antenna. The present invention can flexibly support multiple multimedia services of different quality of service requirements of the transmission in a channel, when the effective allocation of frequency resources, spectrum efficiency, reduce receiver power consumption.


The hike in the demand for smart cities has gathered the interest of researchers to work on environmental sound classification. Most researchers' goal is to reach the Bayesian optimal error in the field of audio classification. Nonetheless, it is very baffling to interpret meaning from a three‐dimensional audio and this is where different types of spectrograms become effective. Using benchmark spectral features such as mel frequency cepstral coefficients (MFCCs), chromagram, log‐mel spectrogram (LM), and so on audio can be converted into meaningful 2D spectrograms. In this paper, we propose a convolutional neural network (CNN) model, which is fabricated with additive angular margin loss (AAML), large margin cosine loss (LMCL) and a‐softmax loss. These loss functions proposed for face recognition, hold their value in the other fields of study if they are implemented in a systematic manner. The mentioned loss functions are more dominant than conventional softmax loss when it comes to classification task because of its capability to increase intra‐class compactness and inter‐class discrepancy. Thus, with MCAAM‐Net, MCAS‐Net and MCLCM‐Net models, a classification accuracy of 99.60%, 99.43% and 99.37% is achieved on UrbanSound8K dataset respectively without any augmentation. This paper also demonstrates the benefit of stacking features together and the above‐mentioned validation accuracies are achieved after stacking MFCCs and chromagram on the x‐axis. We also visualized the clusters formed by the embedded vectors of test data for further acknowledgement of our results, after passing it through different proposed models. Finally, we show that the MCAAM‐Net model achieved an accuracy of 99.60% on UrbanSound8K dataset, which outperforms the benchmark models like TSCNN‐DS, ADCNN‐5, ESResNet‐Attention, and so on that are introduced over the recent years.


Background: The mitanin programme is a Community Health volunteer programme which was initiated by the Government of Chhattisgarh, India in 2002. The mitanin programme further progressed to lay foundation for the Accredited Social Health Activists (ASHA) programme by the National Rural Health Mission. There is robust indication that the community health workers could significantly contribute towards the betterment of health outcomes. The objective was tostudy the awareness and practices of mitanins (ASHA) in rural areas of Bilaspur district. Methods: A community based cross sectional study was carried out among 180 mitanins selected through multistage random sampling in Bilaspur district, Chhattisgarh, India during March to August 2015. A predesigned, pretested questionnaire was used for data collection. SPSS 21.0 version software was used to analyze the data. Results: Most of the mitanins had good knowledge regarding antenatal visits (62.2%) & HBNC visits (52.2%). About (62.8%) had an average knowledge regarding basic cleans to be followed for safe deliveries & regarding danger signs of pregnancy (46.7%). About (36.1%) had poor knowledge regarding symptoms of diabetes & contraceptive advice for spacing (35.6%). About (82.2%) of mitanins had opinion that fast breathing is an indicator of immediate referral of child followed by child unable to drink or breast feed (61.1%). In case of pregnancy, mitanins considered indicators of immediate referral should be swelling of face/hands (90.6%) followed by vaginal bleeding (74.4%). Major activities that they have conducted in last six months includes; accompanying pregnant women for institutional deliveries (92.2%) & participation in immunization sessions (87.8%). Conclusions: Mitanins play vital role in providing primary health care but still they need to put into practice their knowledge about services. Despite the training given to mitanins, lacunae still exists in their knowledge regarding various aspects of health care. Many of them were not aware about family planning, diabetes, tuberculosis, danger signs for pregnancy & newborn that indicate the need for immediate referral.


The University of Melbourne hosts a well-known graduate training program in clinical neuropsychology, which was the first formal training program in neuropsychology established in Australia. What is less well known is that neuropsychology research has a much longer history at the University of Melbourne, beginning in the second decade of the 20th century. This chapter briefly traces the early history, which centered on collaborations between staff at the then Melbourne Teachers College and the university department of anatomy. The historical account then leaps forward half a century to describe some of the University staff and key decisions involved in establishing the graduate neuropsychology training program that continues to the current time. Again, many aspects of this more recent history, including the diversity of staff involved, are not well known. Relying on personal recollections, correspondence between staff, and minutes of faculty meetings, this account aims to pay tribute to the many staff involved in the origins of clinical neuropsychology teaching at the University of Melbourne.


In this paper we propose a novel unsupervised approach to learning domain-specific ontologies from large open-domain text collections. The method is based on the joint exploitation of Semantic Domains and Super Sense Tagging for Information Retrieval tasks. Our approach is able to retrieve domain specific terms and concepts while associating them with a set of high level ontological types, named supersenses, providing flat ontologies characterized by very high accuracy and pertinence to the domain.


This article talks about the calculation of production costs and the roughness after cutting for water jet, laser and plasma cutting processes. It is created a program that calculates productions costs, using empirical mathematical relations for calculating the feed rate and the roughness obtained after cutting. Key words: Cost, calculator, cutting, waterjet, plasma, laser.


Following Farmer's micro‐foundation of the General Theory, I build a competitive search model in which agents are divided in two categories, i.e. wage and profit earners. Within this framework, I show that the model economy has a continuum of equilibria that might be consistent with a certain degree of endogenous real stickiness. Moreover, calibrating and simulating the model in order to fit US first‐moment data, I show that this setting can provide a rationale for the Shimer puzzle, i.e. the relative stability of labor productivity in spite of the large volatility of labor market tightness.


Aurelius Prudentius Clemens (348–after 405 ce) is one of the most important and influential figures in Latin Christian poetry.

Keywords:

Late Antiquity;
literature


Carcinoma‐associated fibroblasts (CAF) promote tumor progression of pre‐neoplastic epithelial cells. To investigate the basis of this phenomenon, we compared the properties of fibroblasts cultured from normal human prostate (NHPF) to prostate CAF. NHPF and CAF were assayed for growth potential, cell death and proliferative capacity by measuring population doubling time, cell cycle distribution and capability to form colonies in soft agar. Resistance to genotoxic (UV radiation: 0–50 J/cm2) and chemotoxic (0–200 nM Taxol) agents were compared between CAF and NHPF by measuring cell viability and cell cycle analysis. Transforming growth factor β1 (TGF‐β1) immunoreactivity was assessed in non‐malignant and malignant prostatic tissue. No detectable differences were found when comparing CAF and NHPF with respect to population doubling time, cell cycle distribution and response to genotoxic and chemotoxic agents. The mean number of colonies in soft agar was 120.5 for CAF vs. 18.2 for NHPF (p < 0.05). Because TGF‐β1 and matrix metalloproteinase (MMP)‐9 have been associated with growth of fibroblasts in soft agar and tumor promotion, we measured the expression of these factors in NHPF and CAF by ELISA. There was no difference in expression of MMP‐9; however, TGF‐β1 was expressed in higher concentrations in CAF than in NHPF (p < 0.0014). Furthermore, TGF‐β1 expression was higher in the carcinoma‐associated stroma of prostate cancer tissue than stroma of non‐malignant prostatic tissue. Increased capability of CAF as compared to NHPF to form colonies in soft agar may be due to a higher expression of TGF‐β1 and correlates with the ability of CAF to promote malignant progression of prostate epithelial cells. © 2004 Wiley‐Liss, Inc.


Corporate social responsibility (CSR) is an integral path towards realizing vision 2030 and the sustainable goals of the UN, as well as the sustainable development of individual countries. However, in recent years it has become increasingly clear that these goals cannot be achieved without sustainable corporate practices. Previous research seeking determine the effect of CSR on the financial performance of various institutions have yielded different results, leaving geographical, sectorial, and scholarly gaps. This study aimed to discover the effect of CSR on the financial performance of financial institutions in Kenya, as this country lacks a direct association between CSR and corporate financial performance (CFP). We focused on examining the effect of ethical, charitable, and gender-mainstreaming CSR activities on the financial performance of financial institutions in Kirinyaga County. A study population of 300 employees working in the financial institutions in Kirinyaga County was included, and a sample of 171 participants was selected using stratified and systematic sampling techniques. A causal research design was adopted, and data were analyzed using SPSS software. Questionnaires were administered in person to gather primary data. The study found a strong positive relationship between CSR practices and the financial performance of financial institutions and recommends that firms invest more in ethical, charitable, and gender-mainstreaming CSR activities, as such activities positively influence their financial performance.


The aim of this study is to determine: (1). Which one gives better mathematics learning achievement, learning with Open-ended or Constructivist, (2). Which one gives better mathematics learning achievement, high, medium or low learning motivation, (3). Which one gives better mathematics learning achievement, learning with Open-ended or Constructivist on each learning motivation of high, medium, or low category. This research is a quasi experimental study with 23 research design. The population of this research is all students on eleven grade of Senior High School. The sampling technique was conducted by stratified cluster random sampling. The samples are the students of SMA N 1 Boyolali, SMA N 3 Boyolali, and SMA N 1 Teras. The instruments which used for data collection are learning achievement tests and student learning motivation questionnaire. The data analysis technique use two-way variance of analysis with unequal cells. The conclusion of the research were drawn as follows: (1) The students with Open-ended learning have mathematics learning achievement better than Constructivist learning, (2). The students with high or medium learning motivation have mathematics learning achievement better than low learning motivation. On the other hand, high learning motivation have mathematics learning achievement better than medium learning motivation, (3). Open-ended learning provides same mathematics learning achievement with constructivist learning on high, medium and low learning motivation.


With few exceptions, the incidence of epilepsy and unprovoked seizures has been reported to be higher in men than in women in both industrialized and developing countries, although this finding does not attain statistical significance in most studies. However, the risk of developing epilepsy differs between men and women according to age. In the Rochester, Minnesota population, the 50-year age-specific annual incidence of epilepsy was similar in the two sexes until about 50 years of age, and was then significantly higher in men than in women (Olafsson and Hauser 1999). Like the incidence, the prevalence of epilepsy tends to be higher in men.


In the last three decades, tribes have initiated numerous food projects, including seed distribution, farmers' markets, cattle and bison ranching, and community and school gardens. These enterprise...


We present RUDIK, a system for the discovery of declarative rules over knowledge-bases (KBs). RUDIK discovers rules that express positive relationships between entities, such as "if two persons have the same parent, they are siblings", and negative rules, i.e., patterns that identify contradictions in the data, such as "if two persons are married, one cannot be the child of the other". While the former class infers new facts in the KB, the latter class is crucial for other tasks, such as detecting erroneous triples in data cleaning, or the creation of negative examples to bootstrap learning algorithms. The system is designed to: (i) enlarge the expressive power of the rule language to obtain complex rules and wide coverage of the facts in the KB, (ii) discover approximate rules (soft constraints) to be robust to errors and incompleteness in the KB, (iii) use disk-based algorithms, effectively enabling rule mining in commodity machines. In contrast with traditional ranking of all rules based on a measure of support, we propose an approach to identify the subset of useful rules to be exposed to the user. We model the mining process as an incremental graph exploration problem and prove that our search strategy has guarantees on the optimality of the results. We have conducted extensive experiments using real-world KBs to show that RUDIK outperforms previous proposals in terms of efficiency and that it discovers more effective rules for the application at hand.


Ultrasonic transducers are widely used in many fields including manufacture and medical. In order to transmit maximal ultrasonic power to an acoustic load in ultrasonic surgery system, measurement of ultrasonic transducer is of great importance. In this paper, performance of ultrasonic surgery transducers with different loads of water and pork bone, pork soft tissues like liver, muscle were measured by Dynamic Signal Analyzer and Network Analyzer. Mason equivalent circuit model was also used to confirm electro acoustic power when ultrasonic surgery transducer was in different loads and to assess the transducer's performance. Results show that under small signals, the ultrasonic transducer has larger output power when contact bone than contact soft tissue or immerse into water.


Imipramine, amitriptyline and desmethylimipramine given alone depressed or did not affect the spinal monosynaptic reflex (MSR). 5-Hydroxytryptophan (5-HTP) alone produced a slowly developing moderate facilitation of the MSR. The 5-HTP-induced increase in the MSR was more rapid in onset and much greater in cats pretreated with imipramine. Imipramine, amitriptyline and desmethylimipramine administered after 5-HTP, when spinal cord serotonin content was elevated, produced, respectively, 4-, 3- and 2-fold increases in the monosynaptic spike height. Cinanserin or methysergide injected subsequent to 5-HTP plus a tricyclic compound caused the MSR to return abruptly toward the predrug height. Similar findings were observed in cats treated with α-methyl-5-HTP. Increased deafferentation of the cord did not reduce facilitation of the MSR by imipramine in 5-HTP-treated animals, but the effect was abolished by chronic spinal transection and greatly reduced by pretreatment (before 5-HTP) with a decarboxylase inhibitor. Our findings indicate that antidepressants given before or after 5-HTP potentiate the 5-HTP-induced facilitation of the MSR via central interaction with serotonin formed from 5-HTP. Decreased neuronal uptake of serotonin may be the mechanism involved in this interaction.


Individual students have different approaches towards learning because of different background knowledge, learning styles and preferences. Therefore, it is difficult for instructors to understand their student best learning approach. Furthermore, web application based on multi-agents for adaptive E-Content has been proposed to assist student individualized learning content in order to enhance their learning outcome.Existing systems normally utilize the main techniques of programming scripts and hierarchical course structure to support adaptive Electronic-Learning (E-Learning) course authoring for diverse category of students. These systems need instructor to obligate significant technical skills, and additionally to employ theories of learning styles, which are challenging requirements. To facilitate instructor to contribute in authoring adaptive E-Learning courses, we have designed web application architecture for administrator, assessor/instructor, and student. Three agents namely the exam agent, message agent and E-Content agent have been created to assist instructor and student. We designed the proposed architecture to be implemented for an online adaptive E-Content and E-Learning system. In addition, we conducted user studies to evaluate the effectiveness of the system.


The title of this book is somewhat more expansive than its contents. The author, a native Ghanaian who holds a Ph.D. from the University of Tennessee and teaches government at South Texas College, reports on an interesting study of human rights/human dignity conceptualizations among the Akan people of Ghana. The Akan constitute about 60% of Ghana's 14 million people and consist of five major groups: Fanti, Ashanti, Akim, Brong, and Akwapim. A sizable Akan population also lives in the Ivory Coast. The author maintains that because the Akan share fundamental values and social structure with many other African peoples, the conclusions of this study can be generalized to Sub-Saharan Africa.


A switch-mode power converter includes a power isolation transformer (T10) and a drive transformer (T20) having their various windings collectively wound on a magnetic core having a center leg and outer legs. A primary winding and one or more secondary windings of the power transformer are wound on the center leg, and first and second windings of the drive transformer are wound on an outer leg. A primary control circuit controls one or more primary switches to supply the input voltage to the primary winding. A secondary control circuit controls secondary switches connected between the secondary windings and a load. Another control circuit controls operation the primary and secondary control circuits based at least in part on a feedback signal. The drive transformer windings are further configured to provide isolation between the primary control circuit and the synchronous rectifier control circuit.


nineteenth-century Indian-white relations, few are as important as the impact of the extension of U.S. criminal jurisdiction over Indian nations. U.S. expansion brought white settlers into intense conflict with Indian nations over lands and resources. Out of the ensuing chaos, turmoil, and violence, a federal response emerged that was genocidal for Indians. Those indigenous peoples who survived the massive deaths through diseases, warfare, and forced migration faced lives under repressive colonial rule. At some point during the transition of Indian nations from independent to subjugated political entities, which varied temporally from one Indian nation to the next, federal and state courts became places where matters involving Indian-white violence were resolved in accordance with white American legal principles and precepts of justice. When pondering these matters, scholars should consider a number of questions. How did Indian leaders respond to demands that they surrender individuals suspected of a violent crime against U.S. society to white authorities for trial? If opting to resist, why did they do so? What were the ramifications of their hesitancy? What types of advantage did U.S. authorities use to coerce Indian cooperation? What roles did institutional and societal racism play in determining if Indians received equal and fair treatment under the law? Were U.S. authorities willing to prosecute its citizens who committed violent acts against Indians? To what extent did racial perceptions shape 13


This paper considers a general stochastic SIR epidemic model driven by a multidimensional Levy jump process with infinite activity and possible correlation between noise components. In this framework, we derive new sufficient conditions for disease extinction and persistence in the mean. Our method differs from previous approaches by the use of Kunita's inequality instead of the Burkholder-Davis-Gundy inequality for continuous processes, and allows for the treatment of infinite Levy measures by the definition of new threshold values. An SIR model driven by a tempered stable process is presented as an example of application with the ability to model sudden disease outbreak, illustrated by numerical simulations. The results show that persistence and extinction are dependent not only on the variance of the processes increments, but also on the shapes of their distributions.


Various coding schemes based on lifting implementation of the discrete wavelet transform applied along motion trajectories have recently gained a lot of interest in video processing community as strong candidates to succeed current state-of-the-art hybrid coders. Still, there are a number of very important issues, including the choice of particular wavelet transform and motion model, that have significant impact on the overall coding performance and will determine usefulness of this class of coders. In this paper, we classify and discuss different motion/transform configurations that are being used in motion-compensated lifting-based wavelet transforms. Our results show that coder performance changes significantly for different combinations of motion models and transforms used.


Corresponding Authors: Oliver Fiehn – West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, Davis, California 95616, United States; email@example.com; Yu-Qi Feng – Department of Chemistry and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430072, PR China; email@example.com. Author Contributions J.D. and T.K designed the experiment. Q.Z., Y.W., and J.Y. performed experimental measurements. T.K. developed the in silico library. J.D. performed the library validation and application. J.D., O.F., and T.K wrote the paper with contributions from all other authors. Complete contact information is available at: https://pubs.acs.org/10.1021/acs.analchem.0c00172 Supporting Information The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.analchem.0c00172. Experimental MS/MS spectra of 12 DMED-FAHFA standards under direct infusion; validation of in silico DMED-FAHFA library with MS/MS spectra obtained from direct infusion of 35 DMED-FAHFA standards; detailed information on identified DMED-FAHFA standards; annotated DMED-FAHFA information in Arabidopsis thaliana by MRM transition and in silico library (PDF) The authors declare no competing financial interest. All data and software are publicly available for commercial and noncommercial use. HHS Public Access Author manuscript Anal Chem. Author manuscript; available in PMC 2021 June 01. Published in final edited form as: Anal Chem. 2020 April 21; 92(8): 5960–5968. doi:10.1021/acs.analchem.0c00172. A uhor M anscript


Delfiol D.J.Z., Cagnini D.Q., Cunha P.H.J., Crosignani N., Wouters A.T.B., Wouters F., Driemeier D. & Borges A.S. 2013. [Clinical and laboratory aspects of sheep supplemented with high levels of sulfur in diet to induce polioencephalomalacia.] Aspectos clínicos e laboratoriais em ovinos submetidos a dietas com níveis elevados de enxofre com objetivo de indução de polioencefalomalácia. Pesquisa Veterinária Brasileira 33(4):435-442. Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618970, Brazil. E-mail: email@example.com Polioencephalomalacia (PEM) is a neuropathologic condition of ruminants that can be induced by a variety of factors including excessive sulfur intake. This study aimed to investigate the relationship between diets rich in sulfur, high levels of ruminal hydrogen sulfide and the occurrence of polioencephalomalacia in sheep. Eighteen sheep were divided into three groups (G1, G2, and G3) and supplemented with 0.2%, 0.9% and 1.2% sulfur in the diet respectively. Clinical evaluation (i.e. heart rate, respiratory rate, rectal temperature and rumen motility) and laboratory exams (i.e. ruminal hydrogen sulfide concentration, venous gas analysis, ruminal pH, serum and liver copper concentration, computed axial tomography, necropsy, and histopathological examination) were performed. Rectal temperature, venous gas and ruminal pH were within normal limits. Tachycardia and tachypnea were observed in sheep of the three groups. Rumen motility was decreased in animals of group G2 and G3 when compared with G1. The higher the sulfur intake, the lower was the serum and liver levels of copper. Increased ruminal hydrogen sulfide concentration was detected in G2 and G3 sheep. None of the animals had clinical signs of PEM. Computed axial tomography, macroscopic and histopathological examination of the central nervous system showed no evidence of PEM. It is suggested that other factors are associated with excessive sulfur consumption for a PEM outbreak to occur in sheep.


The invention discloses air-seasoning alkyd resin prepared from discarded edible oil. The alkyd resin comprises the following raw materials of 10-20 parts of discarded edible oil, 10-20 parts of dry vegetable oil, 6-12 parts of polyhydric alcohols, 0.01-0.02 part of catalyst, 10-15 parts of binary acid or anhydride, 2-8 parts of monoacid and 45-55 parts of diluent. Compared with the prior art, the air-seasoning alkyd resin has the advantages that the discarded edible oil with low price is adopted to replace part of dry vegetable oil or vegetable oil acids used in the traditional formula, the cost of per ton of the prepared air-seasoning alkyd resin can be reduced by about 800yuan, and the property of the air-seasoning alkyd resin is not lower than that of an existing product.


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Background: Population health planning aims to improve the health of the entire population and to reduce health inequities among population groups. Socioeconomic factors are increasingly being recognized as major determinants of many aspects of health and causes of health inequities. Knowledge of socioeconomic characteristics of neighbourhoods is necessary to identify their unique health needs and enhance identification of socioeconomically disadvantaged populations. Careful integration of this knowledge into health planning activities is necessary to ensure that health planning and service provision are tailored to unique neighbourhood population health needs. In this study, we identify unique neighbourhood socioeconomic characteristics and classify the neighbourhoods based on these characteristics. Principal components analysis (PCA) of 18 socioeconomic variables was used to identify the principal components explaining most of the variation in socioeconomic characteristics across the neighbourhoods. Cluster analysis was used to classify neighbourhoods based on their socioeconomic characteristics. Results: Results of the PCA and cluster analysis were similar but the latter were more objective and easier to interpret. Five neighbourhood types with distinguishing socioeconomic and demographic characteristics were identified. The methodology provides a more complete picture of the neighbourhood socioeconomic characteristics than when a single variable (e.g. income) is used to classify neighbourhoods. Conclusion: Cluster analysis is useful for generating neighbourhood population socioeconomic and demographic characteristics that can be useful in guiding neighbourhood health planning and service provision. This study is the first of a series of studies designed to investigate health inequalities at the neighbourhood level with a view to providing evidence-base for health planners, service providers and policy makers to help address health inequity issues at the neighbourhood level. Subsequent studies will investigate inequalities in health outcomes both within and across the neighbourhood types identified in the current study. Published: 10 August 2005 International Journal of Health Geographics 2005, 4:20 doi:10.1186/1476-072X4-20 Received: 15 June 2005 Accepted: 10 August 2005 This article is available from: http://www.ij-healthgeographics.com/content/4/1/20 © 2005 Odoi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The patient was a 63-year-old male who had been on hemodialysis for 19 years because of end-stage renal failure due to diabetic nephropathy and who had been taking oral calcium polystyrene sulfonate (CPS) as a treatment for hyperkalemia. Previously, he underwent detailed tests for progressive anemia and black stools, and was diagnosed with descending colon cancer, for which he was treated by laparoscopic segmental colectomy of the descending colon with D3 lymphadenectomy. The postoperative course was uneventful and the patient was discharged on hospital day 11. However, because subsequent findings revealed progressive anemia and recurrence of bloody stools, lower gastrointestinal endoscopy was performed on hospital day 43. A bleeding circumferential ulcer was found at the anastomotic site and a longitudinal ulcer was detected at a different site. Biopsy of the ulcers revealed basophilic rhomboid deposits on the ulcer floor; thus, involvement of CPS was suspected. Hence, oral administration of CPS was discontinued, and as a result, anemia ceased to progress and subsequent lower gastrointestinal endoscopy showed improvement of the ulcers. Three years have passed and the patient has survived without recurrence of cancer or ulcers.


Due to the strong protection of anonymity, Darknet has been exploited by criminals to distribute harmful content and banned items, such as drugs, weapons, and malware, which are regarded as public hazard entities. The task of public hazard entity recognition can help to detect and analyze malicious activities in the Darknet. This paper focuses on the research of Chinese public hazard entity recognition in the field of illegal drugs. To evade detection and surveillance, Chinese public hazard entities in the Darknet usually utilize disguised forms, like homophones and multi-entities in a sentence, which makes it harder to identify them using traditional entity recognition methods. In this paper, we present an effective deep learning-based multi-information fusion model to identify Chinese public hazard entities in the Darknet. Specifically, we introduce the grammatical information by adding Pinyin and lexical features, and strengthen the semantic features by adding the word vectors from one advanced pre-trained language representation model. Then we combine these three parts with a classical sequence annotation architecture used in general named entity recognition to form our ultimate model. At last we construct a real dataset from drugs-related groups in the Darknet and conduct several experiments to evaluate our model. The experimental result verifies that our proposed model gains a good performance on the recognition of Darknet public hazard entities.


Effective knowledge sharing between organizations of knowledge chain is conducive to the reduction of cooperation cost and fast implementation of knowledge value,while the sharing activity is subject to the trade-off between benefits and costs.In this paper,an evolutionary game model of knowledge sharing between organizations of knowledge chain is built and the influence factors of knowledge sharing are analyzed.Concrete measures to promote knowledge sharing are put forward.


Underwater communication has mainly been driven by the Navy under specific circumstances and challenges. Currently used here are conventional technologies using acoustic transmission, which can only realize data rates up to several kilobits. From the perspective of the operators of a submarine there is a logical prioritization towards covert operation combined with an evolution in data rates. The use of unmanned underwater vehicles (UUVs) in submarine operation enhances the capabilities of submarine missions. The fibre optic link however hampers the submarine's movements underwater and does not provide the anticipated communication "at speed and depth". Cassidian Optronics has developed and patented a special optical method1, wherein these difficulties can be overcome by means of an "optical GPS" . The report describes the underlying process and thereby gives an outlook on the possibilities opened up.


In this paper we investigate the ability of Long- Term Evolution (LTE) network to provide coverage for Unmanned Aerial Vehicles (UAVs) in a rural area, in particular for the Command and Control (C2) downlink. The study takes into consideration the dependency of the large-scale path loss on the height of the UAV, which is derived from actual measurements, and a real-world cellular network layout and configuration. The results indicate that interference is the dominant factor limiting the cellular coverage for UAVs in the downlink: outage level increases from 4.2% at 1.5m height to 51.7% at 120m under full load condition. Lower network loads or larger inter-site distances reduces the interference and thus improves the coverage significantly: outage at 120m is reduced to only 1.9% under network load of 25% for example. Similar effects are expected to be achievable by static or dynamic interference coordination schemes. In addition, ideal Interference Cancellation (IC) scheme with ability to remove completely the dominant interferer shows less effective for UAVs than for users on the ground. On the other hand, macro network diversity has very good potential for drones, as not only it improves the coverage, but also the reliability of the C2 link.


Enzymatic conditions for preparing small peptides from rice proteins with alcalase 2.4L were optimized by single factor experiment and the enzymatic kinetics was established. The optimal enzymatic conditions were as follows: temperature 55 ℃ pH 8.5, enzyme-substrate ratio 0.096 AU/g(substrate). Product inhibition was observed during the enzymatic hydrolysis process, but no substrate inhibition was observed within tested substrate concentration(90 g/kg). The enzymatic kinetic parameters were: k2 = 0.28 mmol/(AU·min), Km= 5.76(g·min)/mmol, and Vmax = 0.67 mmol/(kg·min). The kinetic enzymatic equation was: 1/V0 = 56.29/[S0][E0] + 1/0.28[E0]. After enzymolysis for three hours under the optimal enzymatic condition, the degree of hydrolysis(DH) reached 16% and the hydrolysates content with molecular weight between 264~584 u reached 94%. The molecular weight distribution of hydrolysates was barely changed after 3 h enzymolysis.


The present study was aimed to investigate the bacterial causes of newly born lamb mortalities. Seventy samples were collected (20 apparently healthy, 40 diseased and 10 dead lambs) their age ranged from one day up to 3 months old. The clinical symptoms of diseased lambs were weakness, partial loss of appetite, diarrhoea and respiratory signs. The bacteriological examination revealed that 48 samples (68.6%) were positive for bacterial isolation and 30 (62.5%) and 18 (37.5%) were single and mixed infection respectively. E. coli was isolated at incidence percentage 23(31.9%), Pasturella spp. 16(22.2%), Salmonella spp. 13 (18.1%), Klebsiella spp. 8(11.1%), Staphylococcus aureus 6(8.3%), Streptococcus spp. 4(5.6%) and Pseudomonas spp. 2(2.8%). E.coli isolates were identified serologically into 5 (O 26 ), 7 (O 55 ), 4 (O 101 ) and 7 untyped strains. Also, ٍ ٍ Salmonella spp. was identified as 6 S. typhimurium, 4 S. montividio and 3 untyped strains. In vitro sensitivity test of isolated strains revealed that the most effective antibiotic were sensitive for Enrofloxacin, Cefotaxim and Trimethoprim sulfameth-axazole and should be used in treatment of diseased cases.


Artificial Intelligence (AI) is an emerging technology which aims to make intelligent machines, especially intelligent computer programs. It can be utilized to enable human intelligence onmachines, but the ability of AI does not have to confine itself to biologically observable methods. It can identify hidden relationships, correlations, and trends that may not be apparent in traditional viewpoints. As a result, AI-enabled technologies have achieved significant achievements for medical care including diagnosis, treatment, drug discovery, and healthcare management [1]. Continuousmonitoring of patients plays a crucial role for medical diagnosis and treatment. Nonetheless, existing monitoring techniques have inherent limitations. Numerous methodsnecessitate theuse ofuncomfortable or cumbersome devices, with certain devices even being invasive. Consequently, patients have to face restrictions on their daily activities, and the duration ofmonitoring is curtailed.Moreover, some monitoring methods are cost-prohibitive, demanding specialized equipment and trained personnel for operation. To resolve this challenge, radio frequency (RF) based wireless monitoring schemes which enables contactless, noninvasive and continuous monitoring have been proposed [2]. Specifically, human activities would modulate the propagation of RF signals, which makes it possible to extract human information from the variation of RF signals. Benefiting from AI's ability to identify hidden relationship between signal variation and human activities, contactless self-medication management, Parkinson detection, sleep monitoring and cardiac activity have been achieved the past decade. In the realm of chronic disease management, selfmedication is a prevalent practice. However, due to challenges introduced by inadequate professional guidance and medication adherence, patients often encounter issues related to medication self-administration. Errors in selfmedication can impose additional burdens on both patients and healthcare institutions. To address this, in 2021, Zhao proposed an innovative AI system that analyzes wireless signals within patients' homes to identify errors in selfmedication [3]. Utilizing the reflection of wireless signals from the human body, the system can extract the signal corresponding to the activity of the patient. By applying AI techniques to analyze the signals received by sensors, the system can effectively track specific movements associated with self-medication. Consequently, this approach enables not only monitoring of medication timing but also assessment of whether patients adhere to the correct steps of using the medication device. This wireless sensing-based solution alleviates the burden on healthcare institutions and does not impose any inconvenience on patients' daily lives. For medical treatment, in-depth knowledge of an individual's health status and physiological functions is crucial for healthcare professionals to develop treatment plans and preventive measures. Continuous monitoring of physiological signals such as respiration and heart rate holds significant importance in individual health management, disease prevention, and treatment. Present monitoring approaches typically employ portable and wearable devices to record parameters like heart rate, respiration, and sleep quality. Wireless sensing utilizes reflected signals extracted from the chest and abdomen of the human body to monitor vital signs. This is achieved by analyzing the phase and amplitude variations caused by respiration and heartbeat. In 2021, Wang achieved precise monitoring of human vital signs using commercially available millimeter-wave devices [4], demonstrating median errors of 0.19 breaths per minute and 0.92 beats per minute for respiration and heart rate, respectively. The continuousmonitoring of physiological signals also holds critical significance in disease diagnosis. Parkinson's disease, the world's fastest-growing neurological disorder, had over 1 million patients in the United States as of 2020. Regrettably, there are currently nomedications capable of reversing the progression caused by the Parkinson's disease. Consequently, early diagnosis of Parkinson's disease represents a significant area of research. Traditionally, *Corresponding authors: Yan Chen and Manqing Wu, RCDC-Research Center for Data to Cyberspace, University of Science and Technology of China, Hefei 230026, Anhui Province, China; and Institute of Dataspace, Hefei Comprehensive National Science Center, Hefei 230026, Anhui Province, China, E-mail: firstname.lastname@example.com (Y. Chen), firstname.lastname@example.com (M. Wu). https://orcid.org/0000-0002-32274562 (Y. Chen) Med. Rev. 2023; aop