Background: Ketolides are semisynthetic antimicrobials designed to overcome macrolideresistant (R) S. pneumoniae (SPN). CEM-101 (solithromycin) is a fluoroketolide for oral and/or parenteral therapy of community-acquired bacterial pneumonia (CABP) with superior activity compared to other MLS B agents. Methods: A total of 1,737 (USA, Latin America [LA] and Europe [EU]) and 1,363 (USA and EU) SPN strains were collected in 2008 and 2009, respectively. Solithromycin and comparator agents were susceptibility (S) tested in Mueller-Hinton supplemented with lysed horse blood using CLSI broth microdilution methods (M07-A8). Results: In 2008 and 2009, ≥99.8% of the strains displayed solithromycin MIC values ≤0.5 µg/mL, and 100.0% were inhibited at 1 µg/mL (CLSI breakpoint for telithromycin [TELI]). Six strains showed solithromycin


Wind loads can cause significant vibrations in circular section members, resulting in serious structural hazards. In order to control the vibration of the structure and mitigate the hazards, this study investigates the optimal design and carries out a performance evaluation of a tuned mass damper inerter (TMDI) designed for the vibration control of circular section members in structures. The TMDI system is a novel vibration reduction device that utilizes an inerter based on a tuned mass damper (TMD). The main structure is a simplified Euler beam made up of circular section members, and the mass of the TMDI is coupled to the main structure by a spring and damper, as well as to the ground via an inerter. The optimization objectives are to minimize the displacement variance and maximize the energy dissipation index (EDI), and two different optimization schemes are designed. In addition to the comparative analysis of the results obtained from the different optimization schemes, a sensitivity analysis of the design parameters is also performed, and the results show that TMDI not only effectively reduces the additional mass but also has better vibration control performance and robustness than the TMD.


A variety of (R)-phenylglycinol-derived oxazolopiperidone lactams (1-14) are converted to linear-chain enantiopure aminodiols (15-26) by reduction with LiNH2BH3 in an unprecedented process involving the simultaneous reductive opening of the oxazolidine and lactam rings. The subsequent removal of the phenylethanol moiety gave enantiopure 5-amino-1-pentanols bearing substituents at the 2-, 3-, 4-, 2,2-, 2,32,4and 3,4-positions (28-36), which were isolated as the N-Boc derivatives.


This paper is an examination of the experience of exchange-rate systems since 1978. Despite the accelerating trend in favour of floating exchange rates, a substantial minority of IMF members have continued to fix the value of their currencies. The recent incidence of each of the principal types of exchange-rate peg is described.


Abstract In this work, a novel hydrophilic reactive polyurethane (HRPU) material and HRPU-based composite materials were prepared and used as chemical anti-water erodibility materials for Pisha sandstone. The compressive strength, surface hardness, penetrability and water contact angle were investigated. The results showed that the deformation rate of Pisha sandstone sprayed with HRPU/ethylene-vinyl acetate (EVA) material was approximately 15%, significantly larger than that of other Pisha sandstone samples, while the compressive strength was significantly improved, providing a good penetrability to form a hydrophobic consolidation layer, locking the water in soil. Meanwhile, the micro-morphology of Pisha sandstone was observed by scanning electron microscopy (SEM) images and the water retaining ability of HRPU/EVA material was discussed in detail. The results showed that the water content of Pisha sandstone sprayed with HRPU/EVA material could reach more than 20%, even after 16 h, which presented an excellent water retaining ability. In addition, the anti-water erodibility of Pisha sandstone with HRPU/EVA was improved to prevent soil and water loss, and provide some feasibility for growing plants. Therefore, it could provide a new material and idea to protect the Pisha sandstone area and other erosion areas.


The evolution of the magnetic and structural properties of La 2 / 3 Ba 1 / 3 MnO 3 perovskite manganite was studied as a function of temperature by means of dc magnetic measurements at zero pressure as well as under uniaxial pressure of 0.1 kbar and neutron-diffraction between 5-370 K. It was revealed that below the Curie point T C =314 K in addition to the main crystallographic phase possessing a rhombohedral structure R3c some amount of the orthorhombic Imma phase appears in the system. The system undergoes three magnetic phase transitions in low magnetic fields (of the second order at 300 and 250 K and of the first order at 177.5 K) and passes via a sharp but not complete structural transition R3c↔Imma in the vicinity of T e =200 K. The reduced change of magnetic susceptibility ΔΧ/Χ under uniaxial pressure displays a sharp minimum at temperature T e . Below the Curie temperature from 300 to 250 K the magnetic susceptibility Χ is independent of the temperature, which is considered as an indication of a probable formation below T h =300 K of a long period magnetic structure (probably a sort of low-angle helix).


As part of the effort to reduce accidents on drill floors, the pattern of fifteen years of retrospective accident data involving North Sea drill crews was studied. Of the various patterns examined it was found that there was an increase in accidents in the 0000 - 0400 hours period, and also that accidents rose to a peak in the middle of a two-week shift. Possible factors are discussed and suggestions made to decrease the accident peaks.


In the article the concept domain of linquocultural type hero in British linguoculture is investigated, its structure is determined and its linguistic expression is revealed.


The support plate comprises a cylindrical shaft (1a) designed to cooperate with a cephalic screw (2) previously placed in the corresponding part of the caput of the bone. This plate (1) has a shape and size which allow it to rest on the whirlbone while being arranged to allow at least one stem (3) to be freely engaged and positioned in the medullary canal so that the position of the plate (1) is controlled by the cephalic screw.


The technical achievements in voltage regulator's design and manufacturing fields during the 50 years from 1949 are looked back. The developing trend of various voltage regulators in 21st century is looked forward.


An Introduction to Logic and Scientific Method. By Morris R. Cohen and Ernest Nagel. New York, Harcourt Brace, 1934. xii+467 pp. The plan and purpose are indicated by the following extracts from the preface: "The present text aims to combine sound logical doctrine with sound pedagogy and to provide illustrative material suggestive of the role of logic in every department of thought." . . . "It is especially the hope of the authors that general readers as well as students of the natural and social sciences will find this book helpful towards an understanding of scientific method." The work consists of two Books. Book I, Formal Logic, is a complete and lucid exposition of the formal logic of Aristotle, followed by a selection of material from modern authors, for example, de Morgan, Boole, Peirce, Whitehead and Russell, blended into a consistent whole. Book II, Applied Logic and Scientific Method, is an exposition of the logic of probable inference. The authors first clear the ground by pointing out errors in former treatises on inductive logic, then lay the foundations for an improved exposition by means of chapters on Probability and Induction, Measurement, and Statistical Methods. They show that the structure erected in Book I can be placed on these foundations, and illustrate the scientific method thus constituted by applying it to various fields of knowledge. Chapter 1 forms an introduction to the whole. Book II is followed by an Appendix on demonstrations, Exercises, and the Index. At least a fourth of the book treats mathematical topics. Chapter 6 contains the formal properties of relations, the calculus of classes, and the calculus of propositions. Chapter 7 presents Veblen and Young's postulates for projective geometry, isomorphism, equivalence of axiom sets, independence and consistency of axioms, and mathematical induction. Chapter 8 contains a section on probability. Chapter 14 discusses sampling. Chapter 15 describes the nature of counting, and the measurement of intensive and extensive qualities. Chapter 18 is devoted to statistical averages, measures of dispersion and correlation, and dangers and fallacies in the use of statistics. The work is pleasing and satisfactory. The chapters on Aristotelian and Mathematical Logic, Methods of Experimental Inquiry, Statistical Methods, and Probable Inference in History, are especially good. The method of presentation is excellent. Every chapter is introduced by an explanatory section. Every general statement, every passage which might otherwise be obscure, is explained by instances. Interest is stimulated by the occasional introduction of unconventional expressions, humorous comments, and fanciful examples. The style is flowing and rhythmical, but discursive in places. Occasionally, the combination of long sentences and paucity of punctuation is disconcerting (see p. 233, lines 34-37; p. 356, lines 23-27). The vocabulary is extensive, and includes words, such as equiprobable, musicology, which are not in the dictionaries. The book is well printed in all respects. The authors' presentation of the scientific method differs in an important respect from that actually used in the exact sciences: scientists do not, except to a very limited extent, employ traditional logic in drawing their inferences.


Many disease conditions of the rabbit can affect the liver, and a variety of clinical signs may indicate a diagnosis of liver impairment, either as a primary or secondary condition. However, clinical signs are often non-specific and it may be difficult to make an accurate diagnosis of liver disease in practice. This article describes the clinical signs and diagnostic tests used in making a diagnosis of liver disease in rabbits, and discusses specific liver diseases and their management.


Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus. It is characterised by persistent scaly, disk-like plaques on scalp, face and ears that may cause pigmentary changes, scarring and hair loss. Squamous cell carcinoma can rarely arise within a longstanding DLE plaque in the skin. It presents as an enlarging warty growth or ulcer. We report a case of squamous cell carcinoma which developed on lesion of discoid lupus erythematosus within a short period of time.


This paper presents a technique for analyzing the amount of additives added to the liquid, whose level is to be controlled. The objective of the proposed work is to design a technique which will (i) measure level of liquid independent of solution, (ii) analyze the quantity of additives present in the solution and (iii) design a multi sensor framework to achieve objectives (i) and (ii). Capacitive Level Sensor (CLS) and Ultrasonic Level Sensor (ULS) are used for measurement of liquid level. Respective data conversion circuits are designed to convert output of both the sensor to a standard signal (voltage). For incorporation of Multi Sensor Data Fusion (MSDF) Joint Defense Labortory (JDL) framework is considered. Once the system is designed it is tested with data. Results obtained shows successful implementation of proposed work.


A series of highly conducting lithium siloxyaluminate polymers containing ethylene oxide side chains were prepared. Conductivities of the order of 10-5 S cm-1 at 25 °C were obtained. The materials were shown to be predominantly Li+ ion conductors.


Mechanical devices have been used since the time of antiquity to protect the head from direct impact. Most early helmets were crude shells with little or no padding that were effective against projectiles and penetrating objects. A gladiator's battle helmet is a good example. Early in the 1900's, when automobiles, motorcycles and aviation were in their infancy, padded leather helmets became fashionable, although their protective ability was limited. In the 1950s and 1960s, biomechanical scientists started to understand the impact loads that could cause skull fractures and brain injuries. With this understanding, instrumentation and tests were devised to quantify headimpact exposure and helmet performance. This testing spurred the development of the modern helmet. A modern helmet has energy-absorbing and impact-distributing properties to mitigate lacerations, contusions, skull fractures and brain injuries.


Hopes of applying the findings and speculations of evolutionary theorizing to the problems of ethics have yielded a program with a (deservedly) bad reputation. At the level of norms – substantival ethics – it has been a platform for some of the more grotesque socio-politico-economic suggestions of our times. At the level of justification – metaethics – it has opened the way to some of the more blatant fallacies in the undergraduate textbook. Recently, however, a number of people, philosophers and biologists, have sensed that a more adequate evolutionary ethics might be possible. United in the conviction that it simply has to matter that we humans are modified monkeys rather than the creation of a Good God, in His image, on the Sixth Day, they argue that recent developments in evolutionary biology, especially those dealing with the genetic basis of social behavior ("sociobiology"), open the way to a satisfactory biological understanding of morality.


Summary Irnrnunoreactive insulin (IRI) has been measured in a group of Nigerians. In 39 adults, 23 children and 34 ~egnant \\'Omen IRI in morning blood sampies showed high mean fasting ievels which may be related to the traditional high carbohydrate diet. Fasting plasma insulin levels were all be low 53 #Al/ml and values in males and non-pregnant women were respectively higher than in fernales and pregnant sub jects. The values in children were noticeably ~e.r t~n those reported from elsewhere and no progre~lve nse 111 plasma insulin with age was observed. ~ollo.wlll~ an oral glucose dose in 32 adults, de1ayed maxlrnallIIsulin response was generally observed. In 25% the pattern of ~~ulin res ponse was indicative of prediabetes. However, It IS sug gested that this rather high prediabetic rate may not repre sent the true incidence of the condition but may be partly influenced by gastrointestinal factors which may be peculiar to su bjects in the environment.


A time delay (TD) model of difference-frequency generation in a cavity of a dual-wavelength semiconductor disk laser has been derived. By using the model, the steady state operation point, its stability and transient dynamics of an intracavity difference-frequency generator are analyzed. The identical quantities have been also studied with the help of the normal mode expansion (NME) model. Both models result in steadiness of the steady state points for all parameter's values taken in the simulations. However, the dynamics behaves in rather different manners: the TD model results in the long-lived quasi-periodic relaxation oscillations, while the NME model leads to the fast aperiodic transition to the same steady state point. The time period of the relaxation oscillations equals to the cavity round-trip time.


My bones are trying to speak and so I listen— perhaps I only think I can hear. Sunken in a garden of paper and lights out, you brush over me with a hushed I'm here to—but I was never asleep and I tell you to turn on the light. Every night is the same and I will pine for that peace more than I could morphine, that so-called god of dreams letting me close my eyes but never wander. Excuse me, I'll write an e-mail. Let me sit up, raise my blood pressure from this strange number that strikes pallor in your cheeks. Tonight the dark is the red and the white, the ghosts that are only our reflections in the windows when you forget to turn the lights back out. I take up all this space; flowers are not allowed, counting cell by cell what time looks like. Phone rings—what time zone? And I cover my eyes with the bruised crook of my elbow and know that damnation is not here but on another floor or perhaps at home where nobody calls me miss or says Let's try reading that again, just to be sure.


Introduction Since the 1988 World Health Assembly resolution to eradicate poliomyelitis, transmission of the 3 types of wild poliovirus (WPV) has been greatly reduced.1 WPV type 2 (WPV2) has not been detected since 1999 and was declared eradicated in September 2015. Given that WPV type 3 has not been detected since November 2012, WPV type 1 (WPV1) is likely to be the sole WPV remaining in circulation. This marked progress has been achieved through widespread use of oral poliovirus vaccines (OPVs), most commonly trivalent OPV (tOPV), which contains types 1, 2 and 3 live, attenuated polioviruses, and has been a mainstay of efforts to prevent polio since the early 1960s. Attenuated polioviruses in OPV can undergo genetic changes during replication, and in communities with low vaccination coverage rarely result in vaccine-derived polioviruses (VDPVs) that can cause paralytic polio indistinguishable from the disease caused by WPVs.2


We consider the dark matter (DM) scenarios consisting of the mixture of WIMPs and PBHs and study how much fraction of the total DM can be PBHs. In such scenarios, PBHs can accrete the WIMPs and consequently enhance the heating and ionization in the intergalactic medium due to WIMP annihilations. We demonstrate that the CMB data can give the stringent bounds on the allowed PBH fraction which are comparable or even tighter than those from the gamma ray data depending on the DM masses. For instance, the MCMC likelihood analysis using the Planck CMB data leads to the bound on PBH DM fraction with respect to the total dark matter $f_{\rm PBH} \lesssim {\cal O}( 10^{-10}\sim 10^{-8})$ for the WIMP mass $m_{\chi}\sim {\cal O}(10\sim 10^3)$ GeV with the conventional DM annihilation cross section $\langle \sigma v \rangle=3 \times 10^{-26}~\rm cm^3/s $. We also investigate the feasibility of the global 21-cm signal measurement to provide the stringent constraints on the PBH fraction.


Although the Keynesian multiplier effect of public works is criticized for lack of a microeconomic foundation, it is still taught in most undergraduate courses and believed to be useful for policy makers. However, it has a serious fallacy even if we accept the consumption function. This note shows that useless public works is equivalent to unemployment relief expenditure in the presence of unemployment and that the argument on the multiplier effect seriously misleads the present national accounting and thereby distorts evaluation of public works. A correction of the textbook explanation on the income analysis is also provided.


Through the discussion of using Flash ActionScript in preparing test questions of courseware,we try to explore a program design ideas with simple and flexible method to prepare courseware which had high interaction and free operation,and covered a wide range of question types with a certain degree of extensibility.


By means of rainfall simulation, the mechanism of non-point source pollution of organ ochlorine pesticides(OCPs)by runoff was studied. The results showed that surface runoff perhaps played a more important role than the seepage water in the migration of OCPs from soil to water. The concentrations of OCPs in the runoff decreased with sampling time and then reached stablility after 60 minutes. The soil organic matter affected the trend of migration of OCPs. The concentrations of OCPs in the runoff of the peat soil were relatively high. The total residual OCPs decreased with soil depth. In the depth of0-5cm, the concentrations of OCPs were the highest. Compared to other soil types, the residual OCPs in the peat soil were lowest. The concentrations of OCPs still were relatively high even after 30 days, suggesting that the degradation of OCPs in the soil was very slow.


The article's aim is to present to the Brazilian public the travel journal and drawings from German merchant Ernst Hasenclever about his stay in Brazilian between 1837 and 1844, with particular focus on his first voyage from Rio de Janeiro to Sao Paulo, on Easter 1838


The invention belongs to the field of high polymer composite materials, in particular to a mineral filled flame-retardant acrylonitrile butadiene styrene (ABS) composite material. The composite material comprises the following components in part by weight: 45 to 70 parts of ABS, 1 to 5 parts of compatilizer, 10 to 20 parts of flame retardant, 10 to 25 parts of filled mineral, 5 to 20 parts of ABS high rubber powder, 0.1 to 1 part of antioxidant and 0.1 to 1 part of light stabilizer. The prepared mineral filled flame-retardant ABS composite material has excellent flame-retardant effect, also has good mechanical property and high heat resistance, and is lower in cost.


positive results, whereas negative skin tests were obtained again with Solu-Medrone and Solu-Cortef and also with methylprednisolone sodium succinate, methylprednisolone sodium acetate, hydrocortisone sodium succinate, prednisolone, prednisone, triamcinolone, dexamethasone, cortisone acetate, and the diluent solution. Passive transfer of the positive reactions were negative on three recipients, though the patient's positive skin test to Bermuda grass was passively transferable to each of the recipients. Serial measurements during two intravenous challenges which provoked anaphylaxis showed no significant change in six components ofthe complement system or fibrinogen. The interesting inconsistency between the results of the intravenous challenges and the skin tests is that the succinate salts of the steroid produced symptoms on challenge but only methylprednisolone or hydrocortisone alone gave positive skin tests. Mendelson et al. suggest that small structural changes in the molecule produced by succinylation or acetylation may have been responsible for the negative skin tests.


Professor Gaertner, the well-known pathologist, who has tnade a special study of the variations of blood pressure in normal and diseased conditions of the body, has succeeded in devising a new method for measuring directly the pressure, or rather the minimum of pressure existing at any given time in the right atrium of the heart. The veins standing in direct communieation with the auricle form uninterrupted tubes and can thus be used as a manometer; a simple re-flection will show that under normal conditions a vein which can be brought to the level of the mouth of the vena cava in the right heart, must stand under the same pressure as the right atrium. Very numerous experiments have been made at the clinics of Professors Neusser and Ptl, which gave remarkable results. If the lowered arm of a*healthy person, on which the veins form prominent cords, is raised slowly, the veins will suddenly collapse, when the observed vein is on a level with the atrium venosum dextrum, that is, at the height -of the cartilage of the third to the fifth rib. The difference between the height at which this phenomenon takes place, and the height of the triouspidal valve, measured by the weight of the corresponding blood column, is the pressure in the atrium. Experiments based on these reflections gave the following results: The pressure in the atrium was found tigher than normal whenever other examinations tended to make a stagnation in the pulmonary circulation probable. Thus in all cases of diseases of the mitral and tricuspidal valves, in pericarditis, pleuritic exudation, pulmonary .emphysema, pneumonia, and advanced phthisis. In making the experiment it is necessary to loosen all tight clothes, to stretch the arm, and keep it in slight pronation. Only thih veins should be chosen for observation, as veins with thickened or fibrotic walls will not collapse at the right height. The arm is slowly raised, and at a certain moment the veins collapse. Then the difference of height -(in centicnetres) is measured simply by measuring how far in perpendicular direction the vein is distant from the level of the tricuspidal valve, which can be found either by means of the stethoscope or by Roentg-en rays. If the pressure is very high it may even be necessary to raise the arm above the head of the patient, generally a difference of io to 4ocm. (4 to 06 in.) was found, compared with the normal pressure of about 2 CmU. (4 in.). It is remarkable that higher atrium pressure was found in cases where the patient complained-of uneasiness in the heart region. whilst in all other cases examinations failed to detect any organic lesion of the heart. Thus Gaertner's method will surely be a very useful addition to the physical methods of examination.


The species Anthrenus (s. str.) pueblanus sp. nov. from Mexico, Puebla State is described, illustrated and compared with similar species. The new species differs in the structure of antennae and male genitalia. A key to the Nearctic species of Anthrenus Geoffroy is presented.


The invention relates to compositions CONCENTRATED HARD SURFACE CLEANER, germicides and disinfectants TYPE causing a blooming effect. Such compositions contain the following components: 0.1-10% by weight of a solvent containing terpene desirably includes PINE OIL YD - limonene; 0.1-12% by weight of at least one solvent ORGANICO; 0.1-20% by weight of at least one constituent Nonionic, which desirably includes at least one nonionic HLB GREATER THAN OR EQUAL TO 10; And at least one nonionic surfactant with an HLB value EXCEEDING 8; An effective amount improver efflorescence of at least one amphoteric surfactant, selected from the alkylampho (MONO) Y (DI) - acetates, alkylampho (MONO) - AND DI - propionates and aminopropionates; Optionally a nonionic surfactant ADDITIONAL BASED PRIMARY an alcohol ethoxylate C 8 - C 18 PRESENTING A cloud point of 20 C in water; Germicidally AMOUNTS OF AT LEAST ONE EFFECTIVE Cationic PROPERTIES WITH GERMICIDAL; The rest is up to 100% AND WATER. Concentrate compositions may contain from 0-20% of other optional additives. In embodiments of the invention especially preferred concentrated compositions can be characterized as when these concentrated compositions are diluted in a ratio of 1 part to 64 parts water, 20 or 40 C the resulting mixture has a good transmittance loss LIGHT . Such concentrated compositions provide good features efflorescence when diluted in water to form compositions cleaners and sanitizers therefrom.


The goal of this paper is to explore the cross-domain mapping between music and film and meanings arising from tightly-knight relations among the musics of the film in The King's Speech (2010), written by David Seidler, directed by Tom Hooper, and composed by Alexandre Desplat. We accepted Nicholas Cook's idea that much meanings latent in music can be pulled out and clarified by means of the other media because "music never is alone," illuminating such hidden meanings that a successful mapping between music and film generates. The second movement of Beethoven's Seventh Symphony, which has been adopted for the last public speech scene, forms a close organic relationship to the other soundtracks produced by Desplat. Beethoven's Seventh in addition reinforces the dramatic narrative deployment and generates emergent meanings by carrying an allusive function of foreshadowing the film's conclusion. The 6/4chord, ostinato of the 5, neighboring motion, and rising third line, all of which arise from Beethoven's Seventh, have inspired Desplat in terms of a motive in multiple levels. These motives form two opposite axises of the narrative, despair versus hope, and suggest the final overcome of the stammer either by intensifying desperate moods or by expecting hope.


Stimulated by the vivid search for a theoretical understanding of high-Tc superconductivity, the magnetic properties of low-dimensional quantum antiferromagnetic (afm) systems that contain S = 2 moments on Cu 2 , V4 , or Ti3 ions have attracted particular attention. Unusual ground-state properties have been seen to evolve due to the proximity of such systems to quantum criticality via mainly a considerable sensitivity to higher-order effects in the exchange coupling but also to coupling to lattice or charge degrees of freedom. For example, the spin-Peierls transition observed in the inorganic one-dimensional Heisenberg antiferromagnet CuGeO3 leaves a nonmagnetic singlet ground state below 14 K, which was suggested to arise from the interplay of the nearest neighbor (NN) and the next-nearest neighbor (NNN) Cu–Cu superexchange and magnetoelastic coupling.


LHCII is a largest plant photosynthetic antenna complex. Examination of monomolecular layers of LHCII. with Atomic Force Microscopy reveals formation of regular ring-like structures composed of six trimers of the complex. FTIR analysis of aggregated LHCII suggests that regular supramolecular structures of the complex are stabilized by hydrogen bonding between the α helices C of neighboring trimers. Analysis of fluorescence emission spectra of LHCII-bound chlorophyll a reveals that the aggregation is associated with formation of new electronic energy levels that can be particularly important for both photosynthetic excitation energy transfer and quenching of excessive excitations under overexcitation conditions.


Maternal alcoholism (ethanol and sugar cane brandy) during gestation induces delayed cellular growth and differentiation in fetal rat palate epithelium, with increased nuclear, cytoplasmic and cellular volumes, increased epithelial and keratin thickness and decreased cellular numerical density.


In the last few years, there have been many studies on the dielectric properties of magnetic oxides, mostly in the aspect of the coupling between ferroelectricity and magnetism. These studies have been focused on dielectric anomalies at the magnetic transition temperature, the magnetodielectric e ect, the magnetic relaxor ferroelectricity, materials with high dielectric constants, etc. However, it appears that some of these studies were based on an erroneous interpretation of the dielectric functions measured by using LCR meters. Here, we report rare examples of two-step dielectric anomalies in TbMnO3 and Bi2Fe4O9 that show peculiar frequency dependences. We point out that the thermally-activated charge carriers in isolated impurities are the most probable origin of the dielectric anomalies with the typical relaxor-like frequency dependence.


The changes in China's economic system boost the Internet and lay a solid foundation for the development of the network economy. This paper analyzes the consumers' purchasing behavior and marketing strategy based on mobile internet environment.


The present invention relates to polycarboxylate cements containing glass compositions and their glasses for use in the preparation of polycarboxylate cement, wherein the glass contains SiO


The present study entitled "Bioefficacy study of Bacillus subtilis based biofungicide on leaf spot disease, growth and yield attributes of tomato [Solanum lycopersicum L.] cv. ArkaVikas" was conducted at Vegetable Research Farm, Department of Horticulture, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi during rainy season of 2016-17 in Randomized Block Design (RBD) with three replications. The treatments included foliar spray of chemical fungicide (Copper oxychlooride) and biofungicide (Taegro® and Trichoderma) either alone or in combination. Taegro® is a bacterial biofungicide containing 1×10 10 CFU/g (13%w/w) of Bacillus amyloliuefaciens strain FZB24 formulated as WP. A total of 12 characters including disease, growth and yield parameters were studied. Disease parameter included leaf spot disease incidence (%) and disease severity (%) whereas growth and yield parameters included days to 50% flowering, height, number Original Research Article Tiwari et al.; CJAST, 39(7): 35-41, 2020; Article no.CJAST.55879 36 of branches per plant, fruit length (cm), fruit width (cm), number of fruits per plant, average fruit weight (g), number of seed per fruit, fruit yield per plot (kg), fruit yield per hectare (kg) were studied. The biofungicide Taegro exhibited significant potential in reducing the leaf spot in tomato and improving the growth and yield attributes of tomato as compared to control. But combined used of Taegro with standard chemical copper oxychloride gave better result than Taegro alone. As a consequence, this may be used as part of an integrated disease management approach so as to minimizes the use of standard fungicides and also protect the environment from pollution and maintenance of the human health.


With recent developments in fusion engineering, interest has sparked in development of fusion devices for deterrent. Enormous amount of energy generated by combining two light nuclei could be contained and manipulated at will to trigger and accelerate micro explosions (from shock wave, x-rays or ion beam focusing) which finally result in full scale blast. Materials required to make such device are critical. They must possess high strength, high hardness, ductility, formability, drawability, and anisotropic properties. High entropy alloys (HEA) are new class of materials which nicely fulfils this requirement. Essentially, they are solid solutions of multi principal elements (usually > 5) eliminating the need of base metal as in conventional alloys. This gives them many unique properties which may be tailored at will (heat treatment, cold rolling, precipitation, irradiation). They also exhibit excellent directional properties with formation of distinct bands along certain preferred crystallographic planes even in hexagonal close packed structures. These anisotropic properties are strong function of rolling, working, or forging (swaging) direction and can be utilized to benefit. This study encompasses making outer shell of a typical fusion device selected on the basis of the weight, which is a function of area of pay load bay of carrier aircraft.


This article examines the decision of the CJEU in Brisal and KBC Finance Ireland (Case C-18/15) of 13 July 2016. Following a Portuguese reference for a preliminary ruling, the Court's decision provides further clarification on the permissibility of withholding taxation within the European Union. In relation to interest, the Court held that non-resident taxpayers may be subject to withholding taxes (even if comparable residents pursuing the same activity are not) but that non-residents may nevertheless not be taxed on gross income (when comparable residents are taxed on net profits) and are, therefore, entitled to deduct expenses directly connected to their business activity.


The main experience of Tibetan anti-poverty is that the particularity of Tibetan anti-poverty should be clearly understood,special anti-poverty policies should be constituted,and a comprehensive external supports should be given,detailed measures and practices suitable for the demand and acceptance of Tibetan people should be taken,political consciousness of Tibetan people should be cultivated during anti-poverty process,and international communication and cooperation should be actively developed.


The Portland Cement Association, in 1984, published "Thickness Design for Concrete Highway and Street Pavements," introducing for the first time in any thickness design procedure the concept of pavement component erosion. The erosion criteria were added to the traditional concrete flexural fatigue criteria because heavy-axle loads cause deflections at slab corners and edges, which cause pumping, erosion of the subgrade, subbase, and shoulder materials, voids under and adjacent to the slab, and faulting of the pavement joints. The erosion criteria correlated well to all of the in-service performance data available at the time. These criteria were viewed as first-generation general guidelines that could be refined as field performance data became available on specific climatic and drainage conditions. The aim of this study was to collect performance data that has become available since 1984, and refine the existing erosion criteria to represent different climatic areas and drainage conditions.


'Environmental law' is the law about environmental problems and develops over time as society evolves, and as environmental problems emerge. This chapter considers how environmental problems in the southern catchments have impacted on the evolution, form and content of New Zealand's environmental law over time. The author focuses on four human activities and their associated environmental problems: resource gathering from the twelfth or thirteenth century AD; gold mining during the early 1860s; hydro-electric generation between the 1960s and 1980s; and irrigation for farming.


This observational study demonstrates that the magnitude and location of energization of electrons in the Martian magnetosheath is more complex than previous studies suggest. Electrons in Mars's magnetosheath originate in the solar wind and are accelerated by an electric field when they cross the bow shock. Assuming that this acceleration is localized solely to the shock, the field‐aligned electron distributions in the sheath are expected to be highly asymmetric. However, such an asymmetry is not observed in this study. Based on the analysis here, it is suggested that an additional parallel acceleration takes place downstream of the Martian bow shock. This additional acceleration suppresses the expected asymmetry of the electron distribution. Consequently, along a flux tube in the magnetosheath that is tied on both ends to the bow shock the difference in energization between parallel and anti‐parallel electrons is less than about 20 eV. Where this energization difference is expected to be maximal, we find the energization difference to be at most ≲25% of the predicted value.


In order to analyze the organic matter (OM) composition, this study carefully identified the OM types of 66 samples from Well A in the Dingshan area under microscope, and made an effort to obtain the semi-quantitative statistics contents of different bio-precursor derived OM. The results of OM content obtained under microscope showed a strong positive relationship (R2 = 0.85) with the TOC content analyzed by carbon–sulfur analyzer. The OM contained bethic algae debris, phytoplankton amorphous organic matter (AOM), acritarch, vitrinite-like particles, zooplankton (including graptolite, chitinozoa and others) and solid bitumen which was secondary formation OM. The phytoplankton AOM, graptolite and solid bitumen were the dominated OM in this interval. Solid bitumen (8%~11%) was filled at the bottom of the Wufeng Formation, which could be one reason for the high shale gas production in the lower part of this shale interval. N2 adsorption results showed that micropores and mesopores were predominant in this shale gas system, while pore volumes illustrated better positive relationships with organic matter than minerals, especially AOM content. Thus, both solid bitumen and AOM kerogen were the main sources for shale gas generation in this shale gas system.


The acetone solution of dimethyldioxirane was prepared with caroate (KHSO5) andacetone.This solution can be kept at low temperature(-20℃) for days. It is much conve-nient to use the oxidant for the epoxidation of carbon carbon double bonds in some unsaturat-ed natural products. Five unsaturated compounds were oxidized to the corresponding epox-ides with dimethyldioxirane and the reaction selectivity was discussed.


Globalization is a master historical process of time–space compression (Harvey 1990) between various localities made possible through the employment of modern means of communication and transportation. This process enhances and is reinforced by the expansion of international trade and transnational movement of capital in search of valorization. Globalization may affect major areas of human concerns: from economic and political to the pattern, volume, and intensity of human migration, to transnationalization of migrant communities, to family life and gender relations, to educational institutions, to religious, artistic, and intellectual movements, and to the nature and style of political violence.

Keywords:

economic development;
financial globalization;
international regulation;
social movements and social change


Based on the relations between Hermite and Laguerre Gaussian modes and recurrence algorithm,recurrence formulas of Laguerre-Gaussian(LG) beams propagating through a paraxial ABCD optical system with a rectangular aperture are derived.As an application example,the transformation of LG beams through a system with rectangular aperture and lens separated is studied numerically.The results provide a useful method for the transformation of beams with different geometrical symmetry.


In his Political Treatise, Benedict de Spinoza (1632-1677) describes a frame of government for a federal polity whose members are neither "confederated" nor "united" but are "mutually associated and united. " Spinoza regards thefederal polity as the preferred mode of republican government. His Political Treatise marks the turn in political science from the classic polis to the extended republic of modern times. His argument converges with and illuminates that of The Federalist in several respects. This article discusses Spinoza's contributions to the federal idea, and shows the importance of federalism for understanding Spinoza.


Use of Methylene Blue as a main ingredient in the dye becomes a problem for environmental pollution. It also occurs in the use of coal as fuel is increasing linearly who will be directly proportional to the fly ash waste generated. This study aims to determine the optimum conditions of adsorbent size and the speed of stirring. Adsorption of Methylene Blue performed by mixing with coal fly ash on the condition of adsorbent size (> 100 and 100-200) mesh and stirring speed (160, 180, 200, 220 and 240) rpm. Adsorption results were analyzed by using a spectrophotometer, the optimum conditions obtained capacities variation of fly ash on the adsorbent is 100-200 mesh size and the optimum conditions capacities fly ash at variable speed is 180 rpm. Adsorption shows a decrease in the power jerap fly ash Methylene Blue dye from the initial 10 mg / g adsorbent to 0.666 mg / g of adsorbent.


The authors have derived a universal system of planning charts on "quadragraphs" which can rapidly provide data for economic investment analysis and port planning in developing countries without the need for recourse to long and complex simulations. The charts are demonstrated in application to one form of port traffic. The method for one class of traffic and the research conclusions on which it is based are outlined.


This study concerns classroom noise of high school in Jakarta, Indonesia. Goals of this study are to investigate sources of school noise, effects of noise on teaching and learning of high school students, determine the relationship between noise levels and degree of annoyance. and experiments to reduce school noise levels. 120 students, between ages 19–22 years took part in study. Noise measurements, questionnaire, and experiments for restrictions of noise levels were carried out. Measured noise levels LAeq were ranged between 61.3 and 73.2 dB. There was strong relationship between noise levels and percentage of highly annoyed respondents. Analysis of the responses to the questionnaire found that 57% of respondents said that noise obstructed their learning achievement. Respondents said that road traffic, railway noise, chatter in class room and scraping sounds from tables and chairs were the most annoying sources.Results of restrictions to improve environmental conditions found that, in absence of road traffic noise, maximum reductions LAeq were 12.4 dB. Absence of railway noise, LAeq was decreased 11.3 dB. Absence of chatter in class room and scraping sounds from tables and chairs LAeq was decreased 8.2 dB. This shows that town planner can use various strategies to change school noise composition in order to achieve quieter environments at schools.


Fanfiction has been increasingly thrust into the spotlight of mainstream publishing culture. With the rise of the internet; both access to and production of fanfiction have exploded, and what was previously a private activity has been both normalized and even co-opted into six-figure deals with major publishing houses. Communities of fan writers and readers have not depended on outside authorization; they resist such attempts, preferring to authorize themselves. This tradition of self-authorization has often created conflicts between fan writers and outside interests, both in academia and in the broader realm of "official" content creators and disseminators. Further, fan writing is unusual in that it is presented in both the private and public spheres; it is often available to all readers at the click of a search engine, but fan authors operate in communities that are often literally, if not figuratively, locked to outsiders. Recent incidents such as FicGate, in which students in an undergraduate course began to comment on fan writings on several websites as part of their assignments, polarized both fandom and academics in Fan Studies because it blurred the lines of participation on both sides. In another case, Amazon's Kindle Worlds effort sought to monetize fan authors and fanfiction by licensing certain properties in which fan writers could legally sell their works—provided that they subscribe to stringent limitations on content. Surprising no one (except possibly Amazon) neither corporate franchises nor fan authors were particularly interested in this venture. Using these case studies in tandem with authorship theory, this essay will examine how fandoms effectively "authorize" and empower writers in their community and block out those they deem outsiders, and what this means for those who want to study their writings as a body of literature in their own right.


Abstract We report Dermophthirius carcharhini (Monogenea: Microbothriidae) from the skin of a dusky shark, Carcharhinus obscurus (Carcharhinidae), in the southwest Indian Ocean off Umhlanga Rocks, South Africa, and Dermophthirius maccallumi from the skin of 2 bull sharks, Carcharhinus leucas, in the northern Gulf of Mexico off Cat Island, Mississippi, U.S.A. No previous report exists of a microbothriid from the western Indian Ocean or from off southern Africa or of D. maccallumi from beyond the vicinity of the Lake Nicaragua–San Juan River system. We also provide a list of hosts and localities for members of Dermophthirius.


Exploiting the concept of the dinuclear system, the interaction potential energy of two fragments that are quite close to each other is analyzed. A semi-classical method is used to calculate fission fragment yields using a simplified two-dimensional scission-point model. By considering the tip-to-tip orientation at the scission point of the fission process, we investigate the mass, charge, and kinetic-energy distributions of the fission fragments, for excitation energies in the 0-20 MeV range. Our results show that the fission fragment distributions are reproduced quite well, including the recent experimental results for the isotone chain [D Ramos et al. Phys. Rev. C 97, 054612 (2018)]. Thus, the simplified model is useful for multi-parameter global measurements of fission products.


A rapid method to evaluate the classical turning points of vibrational levels for the electronic states of diatomic molecules whose energy terms can be represented adequately by a quadratic in (υ + 12) is discussed. The method is based on the fact that the internuclear distance "r" corresponding to energy "U" can be represented by an equation of the form y(r) = mx(U) + c, the equation of a straight line. The method is also extended to electronic states whose weye is not very large. To check the validity of these procedures potential energy curves are constructed for X 2Σ+, A 2Π3/2, and A 2Π1/2 states of CN; X 1Σg+ and A 3Σu+ states of N2; and 3Π0u+ state of 79Br81Br. All these values are compared with those obtained by RKRV method. In all cases the agreement is found to be satisfactory, with a deviation of less than 0.1% to RKRV values. Further, a method to check the validity of a Morse function for a particular electronic state is discussed, and a method to adjust the Morse function to represent the true...


CIRAD-CA (formerly IRCT) has participated in cotton research (mainly Gossypium hirsutum), especially cotton breeding, in a number of tropical countries in Africa, Latin America and Asia for 45 years. The work carried out has led to the creation of high quality plant material, well suited to the specific ecological conditions of the countries concerned and whose fiber qualities have progressively joined the best in their category. These varieties (ISA 205, STAM F, ISA 3 19, IRMA BLT, P 288, and glandless GL7) are grown currently on more than 1 500 000 hectares. In the past, ginning outturn, a characteristic of great economical importance, has been improved. In fiber technology, the two main spinning processes (open end and ring spinning) have produced two types of demand, firstly for strong, fine fiber about 1 "3/32 1ong (open end) and secondly for high grade cotton with long, strong fiber (combed ring spinning). In seed technology, the development of glandless varieties can improve returns from cotton growing. CIRAD-CA participates actively in the training of national teams of breeders, provides assistance to the organisation of international research networks (CORAF, Cono Sud) and makes efforts to master the new tools of biotechnology with a view to giving access in the tropical countries to the benefits from progress made in genetic science. The introduction into cotton's genomes of genes providing resistance to insects opens up a new way of research, which could limit the use of insecticide sprays, with an economical and ecological impact on production costs and protection of the environment. (Resume d'auteur)


The simulation of temperature gradient about the infrared optical system was accomplished by finite element analysis,and the imaging quality of system was evaluated. The finite element model of the infrared optical system was established by ANSYS. The deformation of infrared lens' mirror surface under different temperature gradients was analyzed. The Zernike polynomial was used to fit the data of mirror surface after deformation,and the Zernike coefficients were exported to the optical design software ZEMAX for analyzing the image quality of optical system. The results show that the mirror surface of optical element is changed by the temperature gradient,and the aberration of optical system is produced,so the image quality of optical system is decreased. At the same temperature gradient,the effect of the radial temperature gradient on imaging quality is more serious than the axial temperature gradient.


A survey was conducted on cryptosporidial infection of swine on ten counties or cities in Anhui province.Cryptosporidium oocysts were found in fecal specimens from 58 subjects out of the 577 swines inspected with the average infective rate being 10.05%(58/577);The discrepancy of the infective rate of Cryptosporidium among various areas and various ages and sexal swines was compared.The results showed that there was difference in the infection rate of Cryptosporidium among ages and areas,but no difference between sexs.The Cryptosporidium oocysts were identified morphologically as Cryptosporidium parvum.


A dynamic model and differential equation of asymmetric dual-discs overhanging rotor system were establisheel,taking into account the casing elasticity,rotary dynamic excitation of bearings,elastic connection between casing and stator,and gyroscopic effect.Based on the theory of stability,the system stability and the stability regions were studied by investigating the properties of the Jacobi matrix.The effects of different parameters on stability regions of the system were discussed.The step response curves and zero-pole map were utilized for identification of system stability quickly and directly.The results show that rotary dynamic excitation of bearing and rub-impact to against stable operation of the system;The influences of stiffness of the two bearings on stability are basically the same.The influence of the excitation of the two bearings and the rub-impact of the two discs on stability is different obviously.The smaller the elastic connection stiffness between between casing and casing is,and the bigger the elastic connection stiffness between casing and stator is,the better the system stability is.When the bearings stiffness is bigger than the critical stiffness,there appear stability regions in the system;otherwise,there are no such regions.


"Keep falling on left side, dizziness/feeling sick. Permanent pain over my right eye, sleep between 12–14 hours day. Co-ordination not very …


Between April 23, 1996, and June 21, 1996, the U.S. Environmental Protection Agency contracted Haliburton-NUS, Inc., to drill four clusters of three monitoring wells near the Keystone Sanitation Superfund Site. The purpose of the wells is to allow monitoring and sampling of shallow, intermediate, and deep waterbearing zones for the purpose of determining the horizontal and vertical distribution of any contaminated ground water migrating from the Keystone Site. Twelve monitoring wells, ranging in depth from 50 to 397.9 feet below land surface, were drilled in the vicinity of the Keystone Site. The U.S. Geological Survey conducted borehole-geophysical logging and determined, with geophysical logs and other available data, the ideal intervals to be screened in each well. Geophysical logs were run on four intermediate and four deep wells, and a caliper log only was run on shallow well CL-AD-173 (HN-1S). Interpretation of geophysical logs and existing data determined the placement of screens within each borehole. INTRODUCTION The Keystone Sanitation Superfund Site was an active landfill that accepted household, municipal, and some industrial and construction wastes from before 1966 until April 1990. In 1982, the Pennsylvania Department of Environmental Protection discovered volatile organic compounds (VOC's) in an on-site monitoring well and a nearby spring. Subsequent sampling by the U.S. Environmental Protection Agency (USEPA) in 1984 confirmed the presence of VOC's in off-site residential wells. In 1987, the Keystone Site was added to the National Priorities List. The USEPA took the lead on the Remedial Investigation/Feasibility Study (RI/FS) in 1989. The purpose of the RI/FS was to evaluate the nature and extent of hazardous contamination and determine cost-effective remediation alternatives for the Keystone Site. In 1990, a Record of Decision (ROD) was signed by USEPA that specified a landfill cap and ground-water withdrawal and treatment as the remedies for contamination from the landfill site (Operable-Unit 1). In addition, the ROD provided for further study of off-site Operable-Unit 2 (OU-2) contamination. An RI/FS for OU-2 is currently being conducted by Haliburton-NUS, Inc. (NUS), to characterize the nature and extent of hazardous contamination and determine cost-effective remediation alternatives for off-site contamination.


Play for systems and methods for treating water component in the fluid, in which the collection chamber for collecting water from a fluid with a drying agent, is moved to the second fluid to collect water from the desiccant and it includes a chamber. The desiccant evaporator flows into the collection chamber to cool, cooler heats the desiccant flowing into regenerative chambers. Diluted desiccant from the collection chamber, in such a way as to effectively control the movement of both mass and heat between the chamber and replaced with concentrated desiccant from regenerative chambers. In one embodiment, the mass level of the desiccant in one or both of the chamber, not replaced until it exceeds a predetermined level. Heat flow 2 of the drying agent when moving between chambers, conducting between flow 2 of the desiccant. Efficiency is increased by this, to reduce the energy required in the evaporator and condenser. .FIELD 1


In this paper, a digitally controlled boost DC-DC power converter featuring a high-resolution Dyadic Digital Pulse Width Modulator (DDPWM) is proposed to achieve Limit-Cycle oscillations (LCOs)-free operation, high DC accuracy, low output voltage ripple at high switching frequency. The effectiveness of the DDPWM in suppressing the onset of LCOs, increasing DC accuracy, and reducing output ripple is verified by both Simulink/Modelsim co-simulations and experimental testing on a 7-10V input, 13.8V output boost converter operated at 1.17MHz switching frequency. Thanks to the proposed modulator, improvement of more than 6X DC accuracy is achieved compared to a plain digital PWM. Moreover, approximately 3X less output ripple in comparison to a digital PWM with thermometric dithering is achieved.


. A mechanical model for post-mortem striated muscle is proposed. It is based on a combination of a 4-element viscoelastic model with either the Voigt or the Maxwell muscle models. Its applicability was verified by making stress relaxation tests on quadricep muscles from white male rats. The tests were conducted on an Instron Universal Testing Machine equipped with an environmental chamber allowing the specimen to be submerged in Krebs-Ringer solution and maintained at a constant temperature of 38°C.


BACKGROUND
White striping (WS) is a myopathy of breast muscle (Pectoralis major) that affects the quality and consumer acceptance of breast fillets of broiler chickens. Previous studies have shown that intermittent dilution of dietary nutrients suppress the development of WS on the breast muscle of broiler chickens. However, the mechanism by which these interventions reduce the occurrence of WS remains inconclusive. In this study, we adopted intermittent reduction of dietary digestible lysine (dLys) density or metabolizable energy (ME) and amino acid (AA) density using chemical and fatty acid composition of breast fillets, blood metabolites to understand the mechanism while histopathology and immunohistochemistry of breast muscles were used for confirmation.

RESULTS
Occurrence of white striping was lower in broiler chickens fed 85% dLys diets in comparison with other groups. Crude protein and ether extract in breast meat of 85% dLys groups were greater (P < 0.001) and lower (P = 0.010), respectively. Serum concentrations of lipid metabolites and enzymes were lower in broiler chickens fed 85% dLys diets than control group (P < 0.05). Feeding 85% dLys diets had low degree of myodegeneration and necrosis, inflammation, lipid deposition, infiltration of T-lymphocyte (CD3+) and macrophages (Iba-1+), and low expression of heat-shock protein 70 (HSP70) than other groups (P < 0.001).

CONCLUSION
Dilution of dietary dLys to 85% of the required quantities reduces the development of WS in broiler chickens by slowing the growth, lipid synthesis, and muscle damage confirmed by lower extent of histopathological lesions. This article is protected by copyright. All rights reserved.


The prevalent use of chloroform as the anesthetic of choice in many districts of the United States and its use throughout this country almost to the exclusion of ether, and this in spite of the increasing evidence and more or less general knowledge of its grave dangers, induces me to report the following cases. I hesitate to report them only because I am unable to give pathologic data concerning them. The clinical courses, however, of Cases 1, 2 and 3 are so typically those recently attributed to chloroform as the causative agent in producing acute degenerative changes in the liver and an acid intoxication, that I think little doubt can be entertained of the diagnosis. The fact that such changes have been induced experimentally in animals by chloroform, and that clinically nothing else seems to explain the condition so aptly, has led, I think, to the general acceptance of the


This study aims to determine the antimicrobial and antioxidant activities of essential oil components and methanol extracts of Fumaria asepala Boiss. (Akşahtere) and Fumaria schleicheri Soy.-Will. subsp. microcarpa Hausskn. (Şahtere) species grown in Turkey. While essential oils were isolated by the hydrodistillation method, the analysis of these oils was determined by GC/MS device. According to the results obtained, the main component of the essential oil of F. asepala is Phytol (20.74%), followed by Thymol (20.42%), Benzyl Benzoate (15.89%), and Hexahydrofarnesyl acetone (12.92%); It was determined that the main component of the essential oil of F. schleicheri subsp. microcarpa is Benzyl Benzoate (29.07%), followed by Hexahydrofarnesyl acetone (19.72%), n-Hexadecanoic acid (11.40%) and Phytol (10.04%). The disk diffusion method was used to determine its antimicrobial effects. The above-ground parts of F. schleicheri subsp. microcarpa showed the best antimicrobial effect against K. pneumoniae-ATCC 700603 (25mm), while F. asepala showed the best antimicrobial effect against S. aureus-ATCC 25923 (24mm) and K. pneumoniae (24mm). To determine their antioxidant effects, total antioxidant level (TAS) and total oxidant level (TOS) were determined. It was determined that the TAS value of the methanol extract of F. schleicheri subsp. microcarpa at a concentration of 1 mg/ml was 2.8314 mmol, and the TOS value of F. asepala was 3.1610 mmol at the same concentration. It was determined that the total oxidant levels in both species were high.


Clinical trials in accordance with the chained system and evaluated is defined managed. Central authority is subjected to the use of a clinical trial protocol designer to create a protocol meta model. Each metamodel contains a list of preliminary patient eligibility attributes conform to a specific disease type. Protocol designers, selects the metamodel, clinical examination protocols, including eligibility and patient workflows encoded in the meta model. The resulting protocol database is stored in the library. Sponsors and each clinical practice, access to the protocol is restricted. Research site, perform the patient eligibility screening and access to the appropriate protocol database of protocol database library. When a patient is enrolled in the study, the protocol database is shown to the clinician the task to be performed each time the patient visits. This task includes patient management tasks and data management tasks. Workflow graph clinician instructs even time suitable for obtaining the informed consent of the patient. Sponsor is received reports of a patient's progress condition to monitor the progress condition of the patient, the central authorities to produce the performance metrics in response to the report. All components of the system is to use a common disciplined medical terminology database. .FIELD 1


Through sorting-out classification of a lot of literatures,analysis of veneer dryers is made from the angle of heat transfer modes.Some problems with jet veneer dryers and hot-press dryers and relevant measures for improvement are introduced respectively,with suggestions for future research development and application of veneer dryers presented.


In this paper we prove a coincidence point theorem in dislocated metric spaces, provide a supporting example and extend the theorem to dislocated quasi metric spaces. We observe that the supporting example of a result of K.P.R. Rao and P. Ranga Swamy ([7]) , on the existence of a coincidence point for four self maps on a dislocated metric space is not valid . We also make a modification of their result. Mathematical Subject Classification: 47 H 10, 54 H 25.


FIELD: physics, computer engineering. SUBSTANCE: group of inventions relates to dynamically painting user controls. A system for painting user controls on a GUI comprises a computer-implemented tracking module configured to track the position and direction of movement of a cursor on the GUI. Said painting module is configured obtain information on colour using a pixel of an icon included in a separate user control from said plurality of user controls, wherein the separate user control is identified based on the position or direction of cursor movement. The painting module also determines the backlight colour of the separate user control based on the information on colour, wherein the backlight colour is determined based on the dominant colour of the icon. EFFECT: broader capabilities of user navigation on a graphical user interface (GUI) with minimal efforts by tracking the position and direction of movement of the cursor over the GUI. 10 cl, 13 dwg


Urticadioica leaves were powdered and extracted with methanol 70 %. 17 beta-estradiol was used to induce prostatitis. Fifty mice were divided into five groups, The first control group (T1) , The second induction group (T2) was treated by distilled water, the third induction group (T3)was treated with crude extract of Urticadioica leaves 300mg/kg B.W, the fourth induction group (T4) was treated with aspirin 50mg/kg B.W, the fifth induction group (T5)was treated with crude extract of Urticadioica leaves 150mg/kg B.W and aspirin 25mg/kg B.W. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) for induction groups treated with 17 beta-estradiol showed significant decrease as compared with (T1), while the T3,T4 and T5 showed no significant difference as compared with T1. The result of testosterone hormone of (T3) showed significant increase as compared with (T1) and other groups. The results of body and prostate weight for T3,T4 and T5 revealed no significant difference as compared with T1. The fertility index of (T3) was increased as compared with T1 while the T4 was decreased as compared with T1. The histopathological changes after induction of prostatitis revealed hyperplasia of the prostatic glands and  infiltration of inflammatory cells, while the T3 revealed the return of the acini to normal shape, and hydropic degeneration in the epithelium of prostatic glands disappeared. The T4 showed decreased hydropic degeneration, few inflammatory cell and epithelial hyperplasia, while the T5 was characterized by few inflammatory cell infiltration and the acini showed very decreased hydropic degeneration. In this study we concluded that the alcoholic Urticadioica extract could markedly treat proststitis by its anti-inflammatory effect with reduce side effect of aspirin such as infertility.


Dietary antioxidants with yet unproven efficacies in averting prostate cancer (PCa) are widely used in the United States as preventives. Experimental evidence establishing a causal relationship between oxidative and nitrosative stress (OS/NS) and PCa development and showing its modulation by dietary antioxidants would help justify their usage.


Photothermal therapy (PTT) is one of the most promising approaches to combat multidrug‐resistant bacteria with less potential to induce resistance and systemic toxicity. However, uncontrollable distribution of photothermal agents leads to lethal temperatures for normal cells, and failure to offer timely and effective antibacterial stewardship. A pH switchable nanoplatform for persistent luminescence imaging‐guided precise PTT to selectively destroy only pathological cells while protecting nearby normal cells in bacterial infected microenvironment is shown. The PLNP@PANI‐GCS is fabricated by grafting polyaniline (PANI) and glycol chitosan (GCS) onto the surface of persistent luminescence nanoparticles (PLNPs). It takes advantage of the long persistent luminescence of PLNPs to realize autofluorescence‐free imaging, the pH‐dependent light–heat conversion property of PANI to get a stronger photothermal effect at pH 6.5 than pH 7.4, and the pH environment responsive surface charge transition of GCS. Consequently, PLNP@PANI‐GCS enables effective response to bacterial‐infected acid region and electrostatic bonding to bacteria in vivo, ensuring the spatial accuracy of near‐infrared light irradiation and specific heating directly to bacteria. In vivo imaging‐guided PTT to bacterial infection abscess shows effective treatment. PLNP@PANI‐GCS has great potential in treating multidrug‐resistant bacterial infection with low possibility of developing microbial drug resistance and little harm to normal cells.


The differences between sexes and the concept of sex determination have always fascinated, yet troubled philosophers and scientists. Among the animals that reproduce sexually, teleost fishes show a very wide repertoire of reproductive modes. Except for the gonochoristic species, fish are the only vertebrates in which hermaphroditism appears naturally. Hermaphroditism refers to the capability of an organism to reproduce both as male and female in its life cycle and there are various forms of it. In sequential hermaphroditism, an individual begins as female first and then can change sex to become male (protogyny), or vice versa (protandry). The diverse sex-phenotypes of fish are regulated by a variety of sex determination mechanisms, along a continuum of environmental and heritable factors. The vast majority of sexually dimorphic traits result from the differential expression of genes that are present in both sexes. To date, studies regarding the sex-specific differences in gene expression have been conducted mainly in sex determination systems of model fish species that are well characterized at the genomic level, with distinguishable heteromorphic sex chromosomes, exhibiting genetic sex determination and gonochorism. Among teleosts, the Sparidae family is considered to be one of the most diversified families regarding its reproductive systems, and thus is a unique model for comparative studies to understand the molecular mechanisms underlying different sexual motifs. In this study, using RNA sequencing, we studied the transcriptome from gonads and brains of both sexes in five sparid species, representatives of four different reproductive styles. Specifically, we explored the sex-specific expression patterns of a gonochoristic species: the common dentex Dentex dentex, two protogynous hermaphrodites: the red porgy Pagrus pagrus and the common pandora Pagellus erythrinus, the rudimentary hermaphrodite sharpsnout seabream Diplodus puntazzo, and the protandrous gilthead seabream Sparus aurata. We found minor sex-related expression differences indicating a more homogeneous and sexually plastic brain, whereas there was a plethora of sex biased gene expression in the gonads. The functional divergence of the two gonadal types is reflected in their transcriptomic profiles, in terms of the number of genes differentially expressed, as well as the expression magnitude (i.e. fold-change differences). The observation of almost double the number of up-regulated genes in males compared to females indicates a male-biased expression tendency. Focusing on the pathways and genes implicated in sex determination/differentiation, we aimed to unveil the molecular pathways through which these non-model fish species develop a masculine or a feminine character. We observed the implicated pathways and major gene families (e.g. Wnt/b-catenin pathway and Retinoic-acid signaling pathway, Notch, TGFβ) behind sex-biased expression and the recruitment of known sex-related genes either to male or female type of gonads in these fish. (e.g Dmrt1, Sox9, Sox3, Cyp19a, Filgla, Ctnnb1, Gsdf9, Stra6 etc.). We also carefully investigated the presence of genes reported to be involved in sex determination/differentiation mechanisms in other vertebrates and fish and compared their expression patterns in the species under study. The expression profiling exposed known candidate molecular-players/genes establishing the common female (Cyp19a1, Sox3, Figla, Gdf9, Cyp26a, Ctnnb1, Dnmt1, Stra6) and male identity (Dmrt1, Sox9, Dnmt3aa, Rarb, Raraa, Hdac8, Tdrd7) of the gonad in these sparids. Additionally, we focused on those contributing to a species-specific manner either to female (Wnt4a, Dmrt2a, Foxl2 etc.) or to male (Amh, Dmrt3a, Cyp11b etc.) characters, and discussed the expression patterns of factors that belong to important pathways and/or gene families in the SD context, in our species gonadal transcriptomes. Taken together, most of the studied genes form part of the cascade of sex determination, differentiation, and reproduction across teleosts. In this study, we focused on genes that are active when sex is established (sex-maintainers), revealing the basic "gene-toolkit" & gene-networks underlying functional sex in these five sparids. Comparing related species with alternative reproductive styles, we saw different combinations of genes with conserved sex-linked roles and some "handy" molecular players, in a "partially- conserved" or "modulated" network formulating the male and female phenotype. The knowledge obtained in this study and tools developed during the process have set the groundwork for future experiments that can improve the sex control of this species and help the in-deep understanding the complex process of sex differentiation in the more flexible multi-component systems as these studied here.


This paper analyses the uncertainties in probabilistic interpretation of short-term earthquake precursors, even when the statistical information commonly indicated in the literature as sufficient to define the characteristics of these precursors is assumed to be known. The wide margins for uncertainty in the interpretation of such data are pointed out. One of the principal causes of uncertainty, as an example, lies in the physical origin of false alarms. Depending on this physical origin, the conditional probability of an earthquake, other conditions being equal, may vary in certain cases from values around 0–1 to as much as 0–7 or even higher.

The utility of an alarm system, defined as the ratio between the mean number of favourable cases (successful alarms) and the mean number of unfavourable cases (false and missed alarms) is analysed. It is shown that an alarm system based on monitoring n ≥ 2 precursors, if the alarm is set off only after a combination of all precursors, may be considerably less useful than a system based on monitoring only one of the considered precursors.


Strategies applied by urban policy makers in order to achieve sustainable city development may be in conflict with each other because it crosses many disciplines and policy areas. This research focusses on the dilemma between compact city and urban greenspace policies and their influence on actual land-use change in Amsterdam and Brussels. These cases are selected because of their similar urban growth yet diverse policy and governance contexts. We contend that comparing how urban policies try to address this dilemma can provide a deeper understanding of how policy strategies affect land-use change. The results show that densification indeed decreases the quantity (Amsterdam: −4.7% Brussels: −11.9%), average size (A: −3.1% B: −25.6%) and connectivity of urban greenspaces. Observed land-use changes seem disconnected from purported urban greenspace policies, whereas urban development plans seem to dominate changes in greenspace quantity and form.


Abstract : War is a complex phenomenon. The dynamics and complexities associated with modem military engagements, from peace keeping to major regional conflict, demand that the information associated with such environments be carefully selected, framed, and presented to facilitate effective decision making at all levels. We hypothesized that the six fundamental variables of combat represented by the military acronym METT-TC (Mission, Enemy, Troops, Terrain and weather, Time available, and Civilian considerations) would provide a framework from which to efficiently organize and represent the salient dimensions of the battlefield during the military decision-making process (MDMP). The U.S. Army's Crusader Concept Experimentation Program 3 (CEP 3) was selected as an ideal arena in which to conduct a preliminary investigation of METT-TC dimensions and their associations with representative battle command decisions. Subjects were five field grade officers permanently assigned to a U.S. Army combat unit. During a 2-week experiment period, 24 decisions were isolated and documented across three phases of combat operations (delay, defend, attack). Importantly, decision makers reported high levels of both %significance and understanding for most of the dimensions represented by METT-TC, except for civilian considerations, which were not represented in the experimental scenarios. Significant differences in levels of understanding according to decision types (major versus minor) were observed. In summary, experienced military decision makers recognize the importance of METT-TC dimensions, and we suggest that these dimensions offer a means to present aggregate information to increase situational understanding. Further research is recommended to isolate patterns of interactions among these important dimensions across the full spectrum of military operations.


Theefficacy andsafety ofamphotericin B colloidal dispersion (ABCD)were compared withthoseof amphotericin B deoxycholate suspension (ABDS)(Fungizone) ina murine modelofdisseminated cryptococcosis. Miceweretreated intravenously witheither ABDSat0.2, 0.8, or3.2mgtkg ofbodyweight perdose or ABCDat0.8, 3.2, 6.4, 12.8, or19.2mgtkg perdosethree times perweekfor2weeks. Excluding micetreated withABDSat3.2mgJkg, which was acutely lethal in100%ofmice, andABCDat19.2 mg/kg,whichalso resulted intwoearlydeaths, thesurvival ofABCD-andABDS-treated groupswas prolonged oversurvival of controls (P< 0.05). Survival ofABCD (3.2mg/kg)-treated micewas improved overthatofABDS (0.2 mg/kg)-treated mice(P< 0.05); however, comparisons ofmice givenall other dosages ofABCDwithmicegiven sublethal dosages ofABDSdidnotdemonstrate differences insurvival. Comparative fungal burdens inorgans showed adecrease inliver(P< 0.05) andspleen (P< 0.05) burdens forABCDwiththe19.2-mg/kg therapy versusthose withABDSwiththe0.8-mg/kg therapy andliver burdens forABCDwiththe12.8-mg/kg therapy versusABDSwiththe0.8-mg/kg therapy (P< 0.05). There was no difference inorgan burdens between therapy withABCDat0.8mg/kgandABDSat0.8mg/kg. These datashowthat theefficacy ofABCDisequal tothatofABDSon a milligram-per-kdlogram basis formurine disseminated cryptococcosis. Because ofits decreased toxicity, greater efficacy withABCDcould beachieved through doses fourfold higher thanthe100l% lethal doseforABDS.Thus, ABCDshowspromise asan effective butless toxic alternative toABDSforthe treatment ofdisseminated cryptococcosis.


Pyrophyllite, kaolinite + quartz and beidellite were synthesized at 300 and 350°C at 1 kbar within a period of 10 days. For the crystallization silica - alumina gels in salt solutions were used as starting materials. In all cases lowering the temperature from 350 to 300°C results in the formation of only kaolinite and quartz instead of pyrophyllite and sometimes kaolinite. In NaOH and NaF solutions beidellite is formed accompanying pyrophyllite. Some additional experiments with gels containing the cations Na, K, Li, or Ca resulted in the formation of beidellite with sometimes kaolinite. The anions present in the solution and the state and quantity of the interlayer cation and especially the counter anion in solution are important factors determining the phyllosilicate formed under relatively low grade metamorphic conditions and hydrothermal alteration.


The purposeof his research is to know what factors causing the incident of criminal act of neglecting by parent toward their children and to know what detriment which is suffered by children as the consequences of criminal act of neglecting by parent. Method of legal writing in this research used juridical normative research, i.e. by reviewing the Valid Laws, source data which used were primary legal sources and secondary legal sources. Based on the result of this research, thus the factors causing the incident of children neglecting is often related to the mater of prosperity and the lack of parental consideration toward the children's right. This neglecting caused the detriment in children which could influence the growth and development of children in further steps. This detriment comprises of physical and psychological detriments. Thus, the children as the victim of parental neglecting should gain
particular protection, either through as institution or outer institution to relieve the condition of the children, and it should held cooperation from the part of family, society, and government to prevent and eliminate criminal act of children neglecting to the children.


Cholera El Tor, which had been confined for several decades to its original home in the Celebes islands, began to spread out in a pandemic form in 1961. By 1963 most of the islands in the Western Pacific were involved in the pandemic, as were also many countries in South and South-east Asia. By the end of 1963 cholera El Tor had penetrated into East Pakistan, and from April 1964 it has also been present in Calcutta. Thus the Indo-Pakistan subcontinent is now having for the first time a mixed infection of classical cholera and cholera El Tor. In this paper some bacteriological, epidemiological, and immuno logical problems arising from this situation are discussed.


Abstract This paper estimates the effects on production, trade and economic welfare of current trade policy regimes throughout the world on Uganda relative to other economies. This will be a benchmark against which to examine various multilateral and preferential trade policy scenarios that might emerge over the next decade as part of the WTO's Doha Round and from the expected move later this decade towards Economic Partnership Agreements with the European Union. The results suggest modest gains or worse for Uganda, in part because it already has low tariffs and ready preferential access to rich-country markets. Several important caveats to this type of analysis are stressed though, before drawing out some trade and policy implications for Uganda.


Previous consumer research on waste has prioritized disposable and low-involvement possessions. The authors extend scholarship into the context of obsolete buildings as a means to better engage with the complex materiality of waste and to explore the role anti-consumption plays in consumers' valuations of end-stage consumption. This study focuses on the phenomenon of urban exploration, a subculture who seek to discover and explore derelict buildings. Drawing on an ethnographic study including in-depth interviews, the authors reveal how anti-consumption manifests in the urban environment in terms of alternative understandings of value. In contrast to the economic valuations that often dominate public policy decision making, this study highlights the need for policy makers to consider diverse, and perhaps conflicting, value regimes. The authors propose an Obsolescence Impact Evaluation that enables a systematic assessment of the stakeholders potentially impacted by redevelopment and demolition, differing re...


Submit Manuscript | http://medcraveonline.com ultimately progressing to neuroAIDS [1-3]. This is mainly attributed to the integration of the HIV-1 genome into the host genome causing viral latency. The cells that harbor latent HIV typically stay in specific anatomic sites e.g. secondary lymphoid tissue, testes, liver, gut and the CNS [4,5]. The situation is more complicated because in addition to the latent reservoir, other cryptic viral sources exist during HAART, including a very small amount of active virus replication that occurs even during therapy [6]. It is not clear whether this is due to poor HAART penetration into the sites of virus replication or to residual replication that occurs even at ideal drug concentrations. Moreover, neurotoxicity and drug resistance makes the treatment of HIV infection more challenging. Thus, complete eradication of HIV-1 reservoirs from CNS remains a clinically formidable task to cure or treat NeuroAIDS [7].


In order to obtain precise analysis of integer harmonics and non-integer harmonics in power system,firstly,neural network based on a triangle base function with fixed parameters is discussed,by which the frequencies,amplitudes and phases of fundamental and various integer orders of harmonics could be obtained once only.Secondly,an improved triangle base function based neural network is presented——neural network based on a triangle base function with adjusted parameters,precise analysis of integer harmonics and non-integer harmonics is achieved by combining fast Fourier transform(FFT) algorithm with the improved model.The simulation results have verified the effectiveness and practicability of the two algorithms,the higher accuracy of the improved algorithm is verified.It provides a reliable basis for analysis of non-integer harmonics.


This research aims to know the effect of using movie synopsis on students' vocabulary mastery in the first-grade students of MTsN 2 Kota Bengkulu. The population of this research is seven classes of the first-grade students of MTsN 2 Kota Bengkulu; the total number is 301 students. The sample was taken by class VIIB, an experimental class with 30 students, and class VIIA, a control class with 30 students. The instrument of the research used a vocabulary test. The data was evaluated and analyzed to determine the effect using the T-test Formula. The result means that there are differences between both classes in the effect of movies synopsis on students' vocabulary mastery. In other words, the experimental class's vocabulary increased more than the control class. The mean score of the pre-test result of the experimental class was 58,56, the mean score of the control class was 59,86, the mean score of the post-test result of the experimental class was 76,63, and the control class was 61,90. The gain of pre-test and post-test of the experimental class was 18.07, and the gain of pre-test and post-test of the control class was 2.04. It means movies' synopsis as education media was influential in developing students' vocabulary mastery. The researchers suggest that teachers use the synopsis of the movie as one of the techniques in teaching vocabulary, so the teacher can motivate the students to develop their vocabulary mastery and contribute to developing the teaching and learning English process, especially in teaching English vocabulary.


The problems in online purchasing decisions those are made by someone on Shopee e-commerce can be influenced by the advertising creativity and the use of endorsers or the celebrity influencers are as promotional strategies. For this reason, Shopee e-commerce must have creative advertising concepts and choose the right endorser to be able to attract the consumers make online purchases on Shopee e-commerce, it is especially for millennials who are considered the people who make the most purchases online. This study aims to describe how the influence of Advertising Creativity and Shopee Endorser on Online Purchase Decisions in E-Commerce on Business Administration Students, Hang Tuah University of Surabaya. The research method that is used in this study, it is quantitative with the data analysis that is used in the form of statistics/quantitative or numbers. The results showed In accordance with the results of the calculation of the variable regression coefficient, the constants of each Advertising Creativity (X1) and Endorser (X2) variables show a positive value, thus there is a unidirectional effect between these variables and Purchase Decisions (Y) on Shopee e-commerce. In accordance with the results of the multiple correlation test (R) shows the result that is 0.842 and guided by the correlation coefficient 0.90-1000 = very strong, thus it can be concluded that there is a very strong relationship between Advertising Creativity (X1) and Endorser (X2) variables on Purchase Decisions (Y) on Shopee e-commerce. The results of the t-test and f-test together show that the results of each variable simultaneously and partially have a positive and significant effect on Purchase Decision (Y) on Shopee e-commerce.


Abstract : Operational Stress Injury (OSI) is the term used in the Canadian military to describe psychological illnesses resulting from traumatic events experienced by soldiers during operational duties. These include post-traumatic stress disorder, depression and substance abuse. The Canadian Forces and Veterans Affairs Canada have established mental health clinics, called Operational Trauma and Stress Support Centres (OTSSC's), and Operational Stress Injury (OSI) Clinics across Canada to facilitate early diagnosis and treatment of members and veterans suffering from OSI's. Yet it often takes years for traumatized soldiers to present for care. There are many reasons for this. Shame, isolation, and institutional stigmatizing of mental illness are compelling counter-forces to the urge to seek help. Recent research has shown that the fear of stigma is one of the principal reasons why soldiers do not seek treatment, even when they recognize that they are suffering from psychological problems. In contrast to this, the literature tells us that early intervention is a critical factor in decreasing the sequelae of PTSD and other mental disorders.


The article is devoted to the analysis of structural parallels existing between Accius's tragedy «Deiphobus» and Vergilius's «Aeneid». The correspondence revealed points to the fact that Vergilius used scenes of the above-mentioned tragedy quite actively to create numerous episodes of his own poem. This is undoubtedly indicative of the great influence of the ancient Latin tragedy on his creative work.


In 189 of 334 patients, who had been treated with fractionated doses of radio‐iodine for Graves' disease 7–15 years ago, the serum concentrations of triiodothyronine have been estimated in addition to the following parameters: Protein bound 127iodine (PB127I), free thyroxine index, cholesterol‐ and TSH‐level in serum, tendon reflex time and clinical index according to Billewitz et al. (1969). In forty‐one of the 189 sera the free T4 (AFT4) and free T3 (AFT3) concentrations were measured as well. The following hormonal and clinical patterns were observed:


The history of medicine in late fifteenth- and sixteenth-century Portugal cannot be dissociated from the evolution of the monarchy and overseas expansion. Kings and queens were responsible for changes in the institutional structures of charity, creating new hospitals (especially Nossa Senhora do Pópulo in Caldas and Todos-os-Santos in Lisbon) and a new set of confraternities – the Misericórdias – that would take charge of most hospitals in the kingdom from 1564 onwards. Overseas expansion made possible the transformation of the island of Madeira into one of the main producers of sugar, which was then distributed by private persons and institutions, including charitable ones, forming part of medical treatment for the sick poor. Asian spices, also, became common in public and private pharmacies early in the sixteenth century. Through hospitals, which were linked to the royal network of patronage, substances such as sugar and spices became available to the poor.


We study the traffic states and fundamental diagram of vehicular traffic controlled by a series of traffic lights using a deterministic cellular automaton (CA) model. The CA model is not described by a set of rules but is given by a difference equation. The vehicular traffic varies highly with both signal's characteristics and vehicular density. The dependence of fundamental diagram on the signal's characteristics is derived. At a low value of cycle time, the fundamental diagram displays the typical trapezoid, while it shows a triangle at a high value of cycle time. The dynamic transitions among distinct traffic states depend greatly on the signal's characteristics. The dependence of the transition points on the cycle time split and offset time is found.


The magnetic field in circular current expressed by polar equation can be solved by applying the derived polar coordinate form of the Biot-Savart law in magnetic anisotropic medium.The magnetic field with a minimum at the circular center has been verified.


Let the coefficients of the divergence parabolic equation on the Heisenberg group be real valued,bounded measurable VMO functions with respect to a quasidistance induced by vector fields X1,X2,…,X2n and satisfy the uniform elliptic condition.By making use of boundedness of singular integral operators and their commutators on Morrey spaces defined on the Heisenberg group and the freezing coefficients argument,the regularity in Morrey spaces of weak solutions of the divergence parabolic equation is established.


Emergency officers could often benefit from a route planning system that is based on constant traffic monitoring and complex decision making, seeking to give victims another breath of hope by assisting emergency units with reaching them on time. The main challenge is providing responses in a continuously evolving environment within a prescribed time frame, while using limited resources and information that is often incomplete or uncertain. This paper presents a route control concept for emergency vehicles through urban traffic. The proposed genetic controller is designed to dynamically reassess the route while the vehicle passes through the road network, continuously generating new routes based on current traffic. The algorithm is tested in an agent based simulation model that includes both traffic participants and a distributed traffic control system.


The present invention relates to a method for an object with the global satellite system (GNSS) receiver for positioning, according to the present invention, the method comprising the steps of: by the GNSS receiver receives a signal that is located by the said transmitter transmitting the GNSS satellites in line of sight of the object; update service data on an object, said service data includes the satellite clock data clock inside the satellite, satellite orbit data representing the position of the satellite, to the GNSS satellite transmitter delay code offset delay code represents the deviation data and the ionospheric model ionospheric state; ionospheric model based on the data related to said determined signal delay represents the ionospheric delay correction data, the signal is delayed by the signal path through the ionosphere GNSS between the transmitter and transmitting signals received by the receiver of the GNSS signals generated; and based on the signals, the satellite clock data, satellite orbit data, satellite delay code deviation data and the determining ionospheric delay data, determine the position of the object.


Objective To investigate the effect of Endostatin on the expression of NF-κB and MMP-9 in Melanoma cells in vitro. Methods The inhibition of cell proliferation by Endostatin were determined by cell counting kit-8(CCK-8)assay in Melanoma A375 cells. The effect of Endostatin on A375 cells invasion were measured through transwell. The expression of NF-κB and MMP-9 were respectively analyzed by reverse transcription-polymerase chain reaction(RT-PCR)and Western blot. Results Endostatin inhibited the growth of A375 cells in a time-dose dependent manner. After a 72-hour Endostatin (20μg/mL) treatment on A375 cells,the number of membrane-invading cells were (21.5±7.3) and (56.8±6.2) respectively. And the expression of NF-κB and MMP-9 were down-regulated. There was significant difference when compared with control group (all P0.05). Conclusion The effect of anti-invasion or anti-metastasis of Endostatin is caused by downregulating the expression of MMP-9 and NF-κB. These researches provide some theory basis for treating Melanoma cells in clinic.


In this paper we present a generic methodology for calibrating walking models. Applying the methodology to the Nomad walker model improved substantially the quality and significance of the parameters. This methodology aims to describe all aspects of the parameter estimation process of walker models, while making it applicable to the calibration of any walker model. The base of the methodology is the simultaneous calibration of several aspects of pedestrian traffic to improve the robustness and generic application of the model. We investigated the impact of combining different flow configurations, estimating parameters for groups of pedestrians, using errors of pedestrian state variables in the optimisation and introducing prior information about the parameters.


Within the recent years the spatial distribution of Zodiacal dust has been subject to a variety of modelling approaches. Whereas models derived from observations in the visual range tend to demand for an increase of interplanetary matter above the solar poles (bulges), models based on infrared measurements and extended to small r seem to favor a decrease there (holes). The models are reviewed, and the dynamical structure implicated in the models is outlined.