GDP is forecast to grow by nearly 2 per cent this year and in 2019. Our forecasts have been revised higher since November. Annual consumer price inflation peaked at 3 per cent in the final quarter of 2017 and is forecast to ease back to the target rate of 2 per cent over the next eight quarters. We expect the Bank of England to continue normalisation by raising Bank Rate in May by 25 basis point steps and every six months after that until the policy rate reaches 2 per cent.


Although passage of electrolytes into the bile from blood has heretofore been considered to be a passive process of diffusion, present experiments indicate a selective transfer of anions and cations to bile. I/sup 131/ and Br/ sup 82/ in doses of 70 to 100 mu c were injected intravenously into guinea pigs, and the catheterized bile duct was clamped at 10-min intervals. Results with the two isotopes were identical. The concentrations of I/sup 131/ and Br/sup 82/ in successive drops of bile increased rapidly, then more slowly, reaching a max after passage of 10 to 15 drops. This was followed by a gradual decline of isotope content of the bile. The isotope content of blood fell steadily over this period. In other experiments in which the blood concentrations of I/sup 131/ and Br/sup 82/ were maintained constant, no segmental variations in their bile levels were observed. The results indicate that these anions are not transferred across the terminal portion of the biliary tract (distal to the lobules), although the entire tract is permeable to anions. No secretion or reabsorption of the anions could be demonstrated. Contrary to what was previously found with Na/sup 24/ and K/sup 42/, the concentrations ofmore » I/sup 131/ and Br/sup 82/ are always lower in bile than blood, indicating a selective transfer of electrolytes into bile. (H.H.D.)« less


A facile rhodium-catalyzed transannulation of 1-sulfonyl-1,2,3-triazoles with β-diketones was realized, and a series of multisubstituted 2-carbonylpyrroles were synthesized efficiently (up to 94% yield). The protocol features several advantages, such as readily available materials, mild reaction conditions, a concise operating procedure, a broad reaction scope, and excellent regioselectivity when benzoylacetone derivatives were used.


The religious theories are the importance part of Marxist.In the period of revolution and socialism construct,Communist Party of China has been insist to combine together Marxist religious theories and China's reality,and obtained the huge result.The core of party's third generation central leadership collective Jiang Ze-ming comrade,advance with the times,bring forth new ideas in the persistence.At guiding the religion to adapt socialism,hold the relation between religion and the nationalities factor,the different religious cultural with each other harmoniously,enrich and expanded the Marxist religious theories.


New York State Criminal Procedure Law (CPL) 160.59 allows individuals whose criminal records meet certain conditions to seal their records. Applying relevant New York statutes to a sample of criminal histories of individuals applying for gig worker jobs, we estimate the share 2 and number of people who are eligible for this remedy though have not yet taken advantage of it. Approximately one-third of the people in our sample are eligible for sealing their records and thereby falling into the "second chance sealing gap." Extrapolating this share to the estimated 3 number of people with convictions in the state of New York (at least ~2.3M individuals), we estimate that at least 600K people fall into the said gap. According to official state records, since the passage of CPL 160.59 in October of 2017 through Oct 2020, 2,348 people have sealed their records. 1,175 people sealed their record in 2019. At this rate of sealing, it would take 500+ 4 years to clear the existing second chance sealing gap.


Improve the automation and efficiency of hoisting and handling. According to the on-site process and technical requirements, the intelligent hoisting system is designed, and the core machine is developed on the test bench. The application of PLC, servo, configuration and other automation technologies to the development of intelligent hoisting test-bed. The core is the program design of mechanical arm, clamping device, auxiliary suction cup, hoisting, handling and positioning. After testing, the test-bed can realize the variable shape and type of parts, safe and reliable, automatic and flexible work, convenient operation and strongn adaptability.


Objective:To design and construct the expression vector that can express the short interfering RNA(siRNA) against hepatitis B virus X gene,screen the effective target sequence of siRNA and explore the function of siRNA on HBV replication.Methods: The three siRNA against HBx gene were transcript synthesized intracelluarly by expressed templates of plasmid vector pSilencerTM2-U6,and the HBx gene was inserted into the reporter gene in order to construct the recombinant plasmid vector plucF-HBx.The recombinant plasmid and pSilencerTM-U6,which could produce siRNA,were co-transfected into HepG2 cells and screened out the effective siRNA that inhibits the expression of luciferase,the expression of HBx mRNA was detected by reverse transcription polymerase chain reaction(RT-PCR) to further identify the inhibiting function of siRNA on HBx expression,then siRNA were transfected into HepG2.2.15 to analyze the effect of siRNA on HBV replication.Results: One siRNA of the three synthesized siRNA displayed inhibitory effects on the luciferase expression with the inhibitory rate being 76.3%,and could specially inhibit the replication of HBV.Conclusion: Effective siRNA plasmids against HBx gene were constructed and screened out successfully to creat a favourable condition for gene therapy of HBV.


By introducing Clifford Algebra as the theoretical foundation and mathematical tools,a prototype temporal spatial analysis software system was proposed.The characteristics of this system can be summarized as following.① Under the premise of keeping the compatibilities with the commonly used GIS data,a new type of temporal-spatial data model,which unified the expression of both temporal,spatial and attribution components within the multivector structure,was proposed.② Geometric and metric operator libraries were defined,which can support multidimensional temporal spatial analysis.③ Plugging based temporal spatial analysis model constructing and integrating framework was implemented.Typical GIS temporal spatial analysis algorithms like multidimensional V-neighbor analysis,minimum union analysis and unified spatial-temporal process analyses with spacetime algebra were implemented and integrated.Results suggest that the proposed system can support multidimensional temporal spatial analysis effectively,which can also provide reference on improving research on unified temporal spatial analysis methods and GIS systems.


The study assessed the characteristics of successful and unsuccessful public community built and managed secondary schools. The study investigated the factors influencing the level of performance of public built and managed secondary schools in Kinondoni District in Dar es salaam region. The study was guided by three objectives as follow; assess the inputs of successful and unsuccessful, compare the process of teaching and learning and assess the quality of outputs and outcomes of successful and unsuccessful public community built and managed secondary schools.
The study employed a mixed approach method with case study design aimed at determining the factors influencing the level of performance of public community built and managed secondary schools. Purposive and simple random sampling techniques were employed to select 120 participants among the whole group of students and teachers in schools. Data collection included the use of interviews, questionnaires, observations, and review of documents. The data were arranged in columns and rows, and quantitative data were processed and analysed quantitatively and presented in terms of tables, charts and graphs, absolute and relative frequencies.
 The findings revealed that there is a great shortage of teaching and learning materials, teachers, buildings, houses, social services, less supervision from the inspectors and education officers.
The researcher suggests that in seeking the solution to the problem all stakeholders must be involved, allocating enough resources in the education sector, improve teaching and learning materials to schools in remoteness areas, change day to boarding schools, which are in remote areas, improve transport system and create friendly environment in teaching and learning.


Our previous investigation demonstrated that an existing underlying vulnerability in rat neonates (i.e. brainstem 5‐HT deficiency) in combination with a stressor (i.e. pre‐ and early post‐natal nicotine exposure) exacerbates autoresuscitation failure from an anoxic event at a critical developmental period (P10 rats). During this critical period, we hypothesize that caffeine, a respiratory stimulant, will improve successful autoresuscitation rates in the 5‐HT deficient, nicotine exposed P10 neonates and reduce mortality. Preliminary data demonstrate that an intraperitoneal injection of 10mg kg−1 caffeine prior to anoxic challenge improves autoresuscitation rates (survival rate approximately 40%) in the 5‐HT deficient, nicotine exposed P10 rats in comparison to the rats who received IP saline vehicle injections (survival rate of 25%). Prior investigation suggests that eupnea and heart rate recovery following an anoxic event (which elicits an apnea accompanied by a bradycardia) is significantly delayed in 5‐HT deficient rats treated with nicotine, making them more susceptible to failure of autoresuscitation (p<0.05). Presence of caffeine is likely facilitating successful autoresuscitation by shortening apnea duration and promoting an early onset of gasping post‐apnea for a faster eupnea and heart rate recovery.


Pingtan is the largest island in Fujian.It is in the East Asia monsoon region,which is the transition region alternately affected by easterly and westerly belt,with prominent seasonal climatic characteristics.Through statistical analysis of former observation data of Pingtan from the beginnings to 2010,it shows that the mean annual wind velocity is 5.0 m/s in Pingtan.Day with wind of gale force mainly occurs in winter half year,and the extreme wind mostly comes in summer,as a result of tropical cyclone.Leading wind direction axis is obvious in Pingtan,with southwest in summer and northeast in winter.With the development of the building and the shelter belt,annual day with wind of gale force in Pingtan tapers off evidently.


(54) COMBINATION OF TYROSINE KINASE (86). PCT No.: PCT/EP2005/013409 INHIBITOR AND HER-2/NEU FOR CANCER THERAPY S371 (c)(1), (2), (4) Date: Oct. 5, 2009 (76) Inventors: Claudine Elvire Marie Bruck, (30) Foreign Application Priority Data King of Prussia, PA (US); Catherine Marie Ghislaine Dec. 10, 2004 (GB) ................................... O427131.8 Gerard, Rixensart (BE) Publication Classification


Knockdown of KCC2 in the VPM of the thalamus weakens anesthesia. a, Diagram of experimental protocols and transfection of AAV2/9–hSyn– mCherry–miRNAi (KCC2) into the VPM for b. b, Representative images showing AAV2/9–hSyn–mCherry–miRNAi (KCC2)-transfected VPM neurons and comparison of KCC2 expression between groups of infected and uninfected


The small rural church of St Paul's Shipwreck sited on the outskirts of Mosta is known also as Tal-Mingiba. It was built around 1690 on the site of an abandoned earlier small church but, unfortunately, there is hardly any information about it. The present church was blessed by the Rev. Don Ferdinanda Castelletti on 9 February 1695 and it is known that a new cupola was added some time later in the seventeenth century. 1 It seems that for some time there was some difficulty in tracing the provenance of the property of the church. While the parish of Mosta maintained that it had the right of jurisdiction on the small church now it is known that it belongs to the Cathedral Chapter of Mdina.


In this paper, we demonstrate a whispering-gallery-mode microsphere resonator. The device is fabricated by fusion splicing of a section of no-core fiber with multi-mode fiber and single-mode fiber at its two ends. The open end of multimode fiber is etched to create an arc shaped cavity, with a microsphere glued at its bottom. The device has a Q-factor of 1.21 × 104, is robust in structure and of low cost.


Abstract In 1912, the National Union of Women's Suffrage Societies adopted a policy of electoral support for the Labour Party, known as the Election Fighting Fund (EFF). The most determined opposition to this policy came from the South Wales Federation of Women's Suffrage Societies. The article re-examines the story of that opposition, as well as the attempt by the EFF Committee to work in the North Monmouthshire constituency of the Home Secretary, Reginald McKenna, against the wishes of local suffragists. The article suggests that accounts of this period in British suffrage history have presented a too simplistic account, which masks the diversity of women's politics in Wales; and that the nature of coalfield communities combined with the parliamentary focus of the EFF to marginalise the working-class and Labour movement women of the area.


cated as manufacturing and service delivery systems than most uninitiated observers and users may recognize. Dining in a restaurant, whether one is served at the venerable Union Oyster House in Boston or at the window of a new food truck in Portland, requires a contextualized understanding of procedures. What looks simple is not. Restaurants are complex organizations that have evolved over an extended period of human history into heuristic mechanisms, which enable the practical application of many business theories.


: In this paper, we propose a new method for measuring metastability in the mutual exclusion element (MUTEX) implemented on a Field Programmable Gate Array (FPGA). Our method uses fi ne-grained phase shifts of a digital clock manager to trigger Flip-Flops to generate concurrent inputs for a MUTEX. By dynamically adjusting the phase shift between two clock signals, we can force the MUTEX into a metastable state. The bene fi t of our approach is that it is easier to force the MUTEX become metastable compared to the conventional approach using two un-correlated signals. The experiments have been performed on a Xilinx Spartan-6 (XC6SLX9-4TQG144C).


Summary 1. Electron micrographs have been obtained of a fibrous fraction separated from fragmented fresh vitreous humor of cattle eyes by centrifugation, which reveal the presence of three morphologically distinct fibril types. 2. The least numerous species is represented by a fibril 500-800 A in width having an axial periodicity of about 640 A and intraperiod structure characteristic of collagen. 3. A second fibrous component measuring 150-200 A in width is characterized by a repeating axial period averaging about 610 A. 4. A third and most abundant element is a fibril averaging 250 A in width exhibiting only a suggestion of a very fine axial repeating period.


Indonesia is a country with the most economically underprivileged people, many
people whose lives are in shortage so that some are willing to sell themselves to
certain people to earn money. While the crime of human trafficking No. 21 year
2007 on the eradication of criminal acts of Trafficking in Persons, Because of
this factor the police have to work extra to cope with the trafficking of women
kususnya people in order not to continue growing. It takes the role of the police
to overcome it as regulated in Law No.2 year 2002 on the police of the Republic
of Indonesia, in carrying out its role of police, especially the Bantul police
conducts two efforts in the form of; prevention and Repressive efforts (efforts
after the crime).


BACKGROUND: Fallopian tubes are the common surgical specimens in the pathology laboratory. Still there is lack of data to describe the frequency of various histopathological findings. To study the lesions encountered in the fallopian tube. AIMS AND OBJECTIVES: 1. To study the lesions encountered in the fallopian tubes. 2. To study the various histopathological findings of fallopian tubes. MATERIAL AND METHODS: Six hundred and twenty fallopian tube specimens either received separately or as hysterectomy specimens were examined grossly and histopathologically.1 Data collected were analysed. The microscopic findings were analysed based on the clinical diagnosis. RESULTS: Majority (228) cases of tubal pathology with inflammatory lesions followed by ectopic pregnancies (18cases). Primary neoplastic lesions were rare finding. Serial sections of the fallopian tubes and sections from representative areas are essential for a histopathologist so that the diagnosis of these pathological entities is not missed. CONCLUSION: Though the fallopian tubes remain unremarkable in a majority of the surgical pathology specimens, they must be subjected for histopathological examination to evaluate the various pathological lesions.


This article focuses on an emerging phenomenon in Portugal: the most visible and frequent presence of new collective actors in public policy processes. Often linked to philanthropic foundations, these actors call themselves to influence the educational agenda, and even the educational practices, and are highly dependent on expert knowledge. They are intermediary actors who perform cognitive and social operations that connect ideas, individuals and technical devices involved in policy processes. The article analyses the emergence of these intermediary actors and their attempts to influence and reshape the governance of education, through new political networks. Based on earlier empirical-based research inspired by network ethnography, and grounded on the political sociology of public action, the article presents a proposal for mapping these emerging intermediary actors, according to a) the spaces of collective action they use/create; b) their targets; c) their autonomy in the production of expert knowledge for policy. And depicts two trends related to their agency: the use of a more cognitive (rather than normative) regulation, more intensive and knowledge-based, converging to a new interactive and intuitive ways of knowledge dissemination; an increasingly intertwined regulation, involving several different social worlds, promoting and establishing new policy networks and the spread of the new philanthropy reasoning.


The paper deals with a circular economy as a way of sustainable production and consumption. The introductory part describes the basic features of circular and linear economics as well as their differences. The linear economy is based on the principle of "exploit - produce – discard". The aim of the circular economy is to preserve the value of products and materials for as long as possible, to minimize waste and to conserve natural resources. The paper presents examples of good practice of business entities and self-governments whose activities are in accordance with the principles of the circular economy.


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An 80-year-old man with back pain, a rib fracture, and multiple bone lytic lesions was diagnosed with multiple myeloma (MM) by bone marrow (BM) biopsy and transferred to our hospital. The BM aspirate showed many clusters of atypical cells resembling immature neoplastic plasma


One of the biggest goals of the religion of Islam is undoubtedly to build a society where people can live in peace and happiness. In order to realize this purpose, Almighty Allah sent the Qur'an as a book of life and Muhammad (pbuh) as a guide. The Messenger of God built a strong and livable society by realizing the greatest social change in the history of humanity in a short period of time such as twenty-three years, which is the time of his prophethood. Thanks to the method he applied, a period that was accepted as the age of happiness lived in the history of Islam. In this study, the methods applied by the Prophet (pbuh) in building a livable society were examined within the framework of the information in the hadith sources; in the context of hadiths, the universal general principles of building a livable and strong society have been tried to be revealed.


We investigate the effects of electron correlations on the ground-state energy and the chemical potential of a droplet confined by a parabolic potential at high magnetic fields. We demonstrate the importance of correlations in estimating the transition field at which the first edge reconstruction of the maximum density droplet occurs in the spin-polarized regime.


The article examines one of possible ways to solve the daily electric load demand balancing for power system on the basis of the economic motivation of plug-in hybrid, electric vehicles and vehicle-to-grid technology owners. Implementation of this technology has several economic and social advantages, such as additional revenue stream for cleaner vehicles, increased stability and reliability of the electric grid, lower electric system costs and backup for RES operation. To investigate the daily electric load demand, load profiles, electricity demand and production from 2010 to 2013 were analyzed and the consumption of electricity load for 2020 was considered. Economic motivation for EV participation in power markets is based on two-part network tariffs, with price difference for on-peak and off-peak energy. The impacts effects resulting from of the EVs integration into electrical distribution networks reduces the cost of charging for electric vehicles owners.


The (t, alpha ) reactions on even tellurium isotopes (A = 122 to 130) were studied at an incident triton energy of 12 MeV. Alpha angular distributions of transitions leading to states of antimony nuclei were compared to DWBA calculations. Angular momentum transfers and spectroscopic factors were obtained. Present results show significant configuration mixing of the proton wave function in the tellurium targets. Proton hole states in Sb isotopes were located and the two-particle-one-hole interaction is discussed. (auth)


Introduction: To provide evidence to improve cervical screening for women living with HIV (WLHIV), we assessed the accuracy of screening tests that can be used in low-resource settings and give results at the same visit. Methods: We conducted a paired, prospective study among consecutive eligible WLHIV, aged 18 to 65 years, receiving cervical cancer screening at one hospital in Lusaka, Zambia. The histopathological reference standard was multiple biopsies taken at two time points. The target condition was high-grade cervical intraepithelial neoplasia (CIN2+). The index tests were high-risk human papillomavirus detection (hrHPV, Xpert HPV, Cepheid), portable colposcopy (Gynocular, Gynius), and visual inspection with acetic acid (VIA). Accuracy of stand-alone and test combinations were calculated as the point estimate with 95% confidence intervals. A sensitivity analysis considered disease when only visible lesions were biopsied. Results: Among 371 participants with histopathological results, 27% (101/371) women had CIN2+ and 23% (23/101) was not detected by any index test. Sensitivity and specificity for stand-alone tests were: hrHPV, 67.3% (95% CI: 57.7 to 75.7) and 65.3% (59.4 to 70.7); Gynocular 51.5% (41.9 to 61.0) and 80.0% (74.8 to 84.3); and VIA 22.8% (15.7 to 31.9) and 92.6% (88.8 to 95.2), respectively. The combination of hrHPV testing followed by Gynocular had the best balance of sensitivity (42.6% [33.4 to 52.3]) and specificity (89.6% [85.3 to 92.7]). All test accuracies improved in sensitivity analysis. Conclusion: The low accuracy of screening tests assessed might be explained by our reference standard, which reduced verification and misclassification biases. Better screening strategies for WLHIV in low-resource settings are urgently needed.


Objective—Although the metabolic syndrome (MS) is associated with increased cardiovascular risk, its relationship with atherosclerotic progression is less well defined. We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women. Methods and Results—A total of 309 postmenopausal women entered the Estrogen Replacement and Atherosclerosis trial, of whom 248 underwent baseline angiography and completed follow-up angiography after an average of 3.2 years. Women were identified as having type 2 diabetes mellitus (T2DM) or the MS (National Cholesterol Education Panel diagnostic criteria). In adjusted models, participants with T2DM and the MS had greater angiographic progression [change in minimal diameter (&Dgr;MD): −0.15] than women without T2DM or the MS (&Dgr;MD: −0.08; P<0.05) or with MS alone (&Dgr;MD: −0.07; P<0.005); there was no difference in progression by MS status in women without T2DM (P=0.54)]. In adjusted logistic regression models, T2DM predicted coronary heart disease events [odds ratio, 2.79 (95% CI, 1.29 to 6.02)], and the MS demonstrated a similar trend [odds ratio, 1.98 (95% CI, 0.90 to 4.33)]. Conclusions—Among postmenopausal women with coronary heart disease, the presence of diabetes predicted disease progression, but the MS did not.


Coherent and squeezed states for the time-dependent-frequency harmonic oscillator are analyzed using maximum entropy principle techniques. The information-theoretic procedure leads to results equivalent to that of the Wigner-function formalism, although the former gives a physical interpretation of the involved parameters and allows for a nonzero-temperature density matrix


During safety training, students should learn dangers related to machining along with safety and proper procedures. Students could improve their safety understanding if they could experience real dangerous situations under controlled machining conditions. Using a simulator developed by the authors, students can experience danger and fear related to machining accidents. Because lathe machines are typical machining tools, they were selected for modeling for the accident simulator. Five training items including destruction of work and tools were chosen as actual accident models for demonstration by the simulator. This accident simulator was introduced into the education schedule of machine manufacturing safety training. Questionnaire survey responses indicated improvement in students′ recognition about safety and the dangers of machining work.


Abstract : This award has supported the development of new approaches and algorithms for inference problems on networks. These have been validated by experiments demonstrating their utility in detecting spam web pages. It has also supported the development of faster algorithms for determining which edges are most critical to the structure of a network.


Software to design resonators and diffusors covers specific devices; such as,
diaphrgmatic resonators, resonators of Helmholtz and the diffusors of
Schroeder. The system is developed with Microsoft .NET technology. To design
this software, an exhausting analysis on Architectural Accoustic dispositives
was done. Then, an algorithmic abstraction of the processes was done to
design the accoustic devices. Once the process algorithm was generated,
programming on Visual Basic .NET was introduced to generate forms and
necessary events for setting up the program.


Bandwidth efficient turbo coding schemes attract increasing research interest these years, most of these schemes are constructed by non-binary convolutional codes and need to be decoded symbol by symbol instead of bit by bit. In this paper, a modified symbol based SOVA decoding algorithm for non-binary turbo codes is proposed. Using our symbol based SOVA algorithm, soft output information from the prior iteration can be accepted as a priori soft input information for current iteration. The experimental results show that our algorithm can achieve close performance to MaxLogMAP algorithm for large interleaver size with lower complexity, and the performance loss of the SOVA compared to the optimal MAP algorithm is only about 0.3 dB at a BER of 10-4


The title compound, {[UO2(C9H4O6)(H2O)]·H2O}n, is a novel material consisting of a [UO2]2+ ion bonded to five O atoms, four of which are from three separate 1,3,5-tricarboxylic acid molecules, while the fifth is from a coordinated water molecule. This connectivity gives rise to chains running in the [01\overline 1] direction.


Sexual predatorstatutes require thatanoffender beeval uated for civil commitment, after completing his penal sentence, by psychiatrists, psychologists, and other mental health professionals. These professionals are usually asked todetermine whether theoffender: (1) has been convicted of sexually violent predatory offenses against twoor morevictims; (2) has a "mentalor behav ioral abnormality" that predisposes the person to the commission of criminal sexual acts; (3) is likely to en gage in sexually violent criminal behavior as a result of hismental or behavioral abnormality. Despite the fact that theAmerican Psychiatric As sociation believes that these statutes represent a mis useof psychiatry and are primarilyaimed at preven tive detention, the U.S. Supreme Court upheld their constitutionality in Kansas v. Hendricks.1 Similar statutes have been passed in about 16 states. The Supreme Court catalogued constitutionally permis sible instances in which "[s]tates have in certain nar rowcircumstances provided for the forcible civil de tainment of people who are unable to control their behavior and who thereby posea dangerto the public health and safety."2 In the aftermath, state depart ments of mental health have rushed to set up mech anisms to evaluate sex offenders who arecompleting their sentences. These officials have turned to mental health professionals to design and then perform these evaluations. Many professionals, like good soldiers, have charged into the breach and are attempting to do the best possible job. In their efforts to bolster clinical assessments, they are using a variety of new questionnaires and actuarial formulae. They are in terviewing offenders who agree to the interviews. Many offenders, understandably, refuse to be coopera tive with these assessments. The profession and the courts are learning a whole new list of acronyms for these tests, which include the following: Sexual Vio lence Risk-20 (SRV-20); Rapid Risk Assessment for Is the "best possible" job ethically and scientifi cally good enough? The courts have been increas ingly concerned with the introduction of "junk sci ence." Since 1923, Frye v. U.S. has served as a standard for determining whether expert testimony would "assist the trier of fact."3 Frye requires that expert testimony be supported by scientific princi ples or evidence that are "generally accepted" by the relevant scientific or professional communities. In the 1993 case of Daubert v. MerrellDow Pharmaceu ticals, the Supreme Court rejected the Frye test and construed Rule 702 of the Federal Rules of Evidence to create a "gatekeeper" function for federal judges.4 Daubert defined a four-prong …


Objective For Bushentianjing class of oral agents for the treatment of erectile dysfunction and other male disease Exploration. Methods Dozens of male patients randomly selected, and then were divided into two groups, one for the treatment group to another as the control group. In terms of its important conditions no significant differences, which contrast effects can explain the problem, compared to experimental data and other information obtained has a reference value. Results The two groups of patients with the disease has been effectively alleviate and had improved accordingly. Under the two groups found slightly higher in the treatment group rehabilitation efficiency. Groups of patients treated by taking liquid eased its complications, but with the corresponding control group after taking the rest kind of medicament improvement is not obvious. Conclusion Bushentianjing wide range of applications due to its oral, play a role in efficient use of safety features can be used in clinical care


Although the state has always attached great importance to the problem of employment of women at present, women in employment is still subject to many discrimination, encountering unfair treatment in the recruitment, training, promotion and other links of women. This affects the development of social economy, and also hinders the progress of the society. In this article, the cause of Chinese women' s employment discrimination is analyzed from a philosophical perspective, as well as current situation of employment and the change of women's strategy. The internal cause of the development of things should be put forward to improve women's consciousness of independence and comprehensive occupation quality. At the same time, it is to improve the external conditions of female employment based on the development of things external.


Cl−/HCO  3− exchanger and Na+/H+ exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases in Na+ excretion and consequently increase blood pressure. The present study investigated mechanisms by which H2O2‐induced stimulation of Cl−/HCO  3− exchanger activity is enhanced in proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHR) as compared to normotensive Wistar Kyoto (WKY). H2O2 decreased Km values for Cl−/HCO  3− exchanger activity in SHR PTE cells, but had no effect on the kinetic parameters in WKY cells. DTDP stimulated in a concentration‐dependent manner Cl−/HCO  3− exchanger activity in both cell lines, but SHR PTE cells were 2.4‐fold more responsive to this oxidant. In contrast, thimerosal had no effect on exchanger activity in both cell lines. The effects of H2O2 and DTDP upon the exchanger activity were blocked by DTT in WKY and SHR PTE cells. Similar to H2O2, DTDP decreased Km values for Cl−/HCO  3− exchanger activity in SHR PTE cells. Basal content of free thiol groups was higher in WKY PTE cells than in SHR. Upon H2O2 treatment the free thiol groups decreased in both cell lines; however, this decrease was more pronounced in WKY cells. In conclusion, in SHR PTE cells H2O2 stimulates Cl−/HCO  3− exchanger activity via modification of thiol groups of intracellular and/or transmembrane protein. Furthermore, the thiol oxidation‐dependent pathway also increases the HCO  3− affinity in SHR PTE cells. J. Cell. Biochem. 112: 3660–3665, 2011. © 2011 Wiley Periodicals, Inc.


(abridged) Context. Wide binaries are a potential pathway for the formation of hot Jupiters. The binary fraction among host stars is an important discriminator between competing formation theories, but has not been well characterised. Additionally, contaminating light from unresolved stars can significantly affect the accuracy of photometric and spectroscopic measurements in studies of transiting exoplanets. Aims. We observed 101 transiting exoplanet host systems in the Southern hemisphere in order to create a homogeneous catalogue of both bound companion stars and contaminating background stars. We investigate the binary fraction among the host stars in order to test theories for the formation of hot Jupiters, in an area of the sky where transiting exoplanetary systems have not been systematically searched for stellar companions. Methods. Lucky imaging observations from the Two Colour Instrument on the Danish 1.54m telescope at La Silla were used to search for previously unresolved stars at small angular separations. The separations and relative magnitudes of all detected stars were measured. For 12 candidate companions to 10 host stars, previous astrometric measurements were used to evaluate how likely the companions are to be physically associated. Results. We provide measurements of 499 candidate companions within 20 arcseconds of our sample of 101 planet host stars. 51 candidates are located within 5 arcseconds of a host star, and we provide the first published measurements for 27 of these. Calibrations for the plate scale and colour performance of the Two Colour Instrument are presented. Conclusions. We find that the overall multiplicity rate of the host stars is 38 +17 -13%, consistent with the rate among solar-type stars in our sensitivity range, suggesting that planet formation does not preferentially occur in long period binaries compared to a random sample of field stars.


THE NEW AASHO LOAD FACTOR SPECIFICATIONS ARE PRESENTED FOR DESIGNING PRESTRESSED CONCRETE HIGHWAY BRIDGES. THE EFFECTS OF THE NEW LOAD FACTOR EQUATIONS ON BOTH PRECAST-PRESTRESSED CONCRETE AND CAST-IN-PLACE POST-TENSIONED CONSTRUCTION ARE DESCRIBED. THE NEW LOAD FACTORS HAVE SUBSEQUENTLY BEEN INCORPORATED INTO THE 1973 AASHO SPECIFICATIONS FOR HIGHWAY BRIDGES. /PCIJ/


Introduction: Although multiple myeloma (MM) is typically described as an incurable disease, it has been shown in recent years that a small fraction of patients may reach more than 10-years progression-free survival (PFS), which is considered as the minimum threshold to identify patients in "operational cure". However, because of the scarcity of available data there is significant lack of knowledge in MM regarding the frequency of cases attaining operational cure, nor the existence of biomarkers that could prospectively predict such curability. Methods: Herein, we sought to define the frequency as well as the biomarkers predictive of operational cure in a large series of uniformly-treated transplant-eligible patients enrolled in the PETHEMA/GEM2000 protocol (VBMCP/VBAD followed by HDT/ASCT and 2 years of maintenance with interferon and prednisone). Patients9 follow-up was updated at the time of abstract submission, and the median follow-up of the series is now of 12-years. We used an automated multiparameter flow cytometric (MFC) classification model focused on the analysis of the bone marrow plasma-cell compartment to identify among newly diagnosed symptomatic MM those with MGUS-like vs. MM-like phenotypic signatures. Minimal residual disease (MRD) was monitored using a first-generation 4-color MFC assay (CD38-FITC / CD56-PE / CD19-PerCPCy5.5 / CD45-APC) with a limit of detection of 10-4. PFS and overall survival (OS) were measured from the time of diagnosis. Results: From a total of 1075 patients enrolled in the GEM2000 protocol, 763 were eligible for this analysis because they either relapsed or died during the first 10-years from diagnosis (n=666; 87%), or remained progression-free and alive for more than 10-yers (n=97; 13%); accordingly, all patients remaining progression-free and alive but for which the follow-up was inferior to 10-years were excluded from the analysis. We then investigated the biomarkers that could help to identify patients reaching operational cure after HDT/ASCT. As compared to the vast majority of cases, patients reaching >10-years PFS (13%) had significantly less frequent anemia (76% vs. 60%, respectively; P=.002), as well as more frequent Durie-Salmon stage IA (14% vs. 6%; P=.004), MGUS-like signature as determined by the automated MFC algorithm (28% vs. 6%; P 10-years PFS vs. those who relapsed earlier. On multivariate analysis, only the presence of an MGUS-like signature at baseline (P=.04; HR: 3.9) and MRD-negativity at day+100 after HDT/ASCT (P=.006; HR: 6.3) emerged as independent predictive markers for >10-years PFS; anemia, Durie-Salmon and CR status were not retained in the logistic regression model. Accordingly, patients with an MFC-defined baseline MGUS-like signature reaching MRD-negativity after HDT/ASCT (n=14) had a median PFS of 10-years and a 10-year OS rate of 79%, which were significantly superior to those observed among cases with MM-like signatures being MRD-negative (n=54) or positive (n=99) after therapy [median PFS of 6 and 3 years (P Conclusions: We demonstrated that operational cure (i.e.: >10-years PFS) was possible for 13% of transplant-eligible MM patients before the era of novel agents. Curability rates were particularly frequent among patients with a benign phenotypic signature at diagnosis and MRD negativity after HDT/ASCT, suggesting a remarkable clinical benefit of attaining deep remissions after intensive treatment for patients with early MM. Disclosures Paiva:Sanofi: Consultancy; Janssen: Consultancy; Millenium: Consultancy; Onyx: Consultancy; BD Bioscience: Consultancy; EngMab AG: Research Funding; Binding Site: Consultancy; Celgene: Consultancy. Puig:The Binding Site: Consultancy; Janssen: Consultancy. Mateos:Takeda: Consultancy; Celgene: Consultancy, Honoraria; Onyx: Consultancy; Janssen-Cilag: Consultancy, Honoraria. San Miguel:Celgene: Honoraria; Bristol-Myers Squibb: Honoraria; Onyx: Honoraria; Sanofi-Aventis: Honoraria; Novartis: Honoraria; Millennium: Honoraria; Janssen-Cilag: Honoraria.


According to Amartya Sen (1992) "Women Empowerment is the ability of women to exercise full control over one"s actions and is one of the central issues in the process of development for many countries in the world today." Women are empowered when they have the freedom to control and command their own lives. Economic empowerment increases women"s access to economic resources and opportunities including jobs, financial services, property, skill development and market information. One way of ensuring such economic empowerment of Indian women is through 'enhanced role of education'. This paper aims to focus on the economic empowerment of women by considering the enhanced role of education to eradicate gender inequality. This study tries to establish the importance of education by means of primary data collection and analysis in Delhi region for educated and uneducated women and ascertain the detrimental role of the same in the economic empowerment of women.


The Riemann hypothesis states that the Riemann $\xi(s)$ function has no zeros in the strip $0<{\rm Re}(s)<1$ except for the critical line where ${\rm Re}(s) = 1/2$. However, determining whether a point in the strip is a zero of a complex function is a challenging task. Bombieri proposed an assertion in the Official Problem Description that states, ``The Riemann hypothesis is equivalent to the statement that all local maxima of $\xi(t)$ (namely $\xi(s)$ on the critical line) are positive and all local minima are negative."In this paper, we follow Bombieri's idea to study the Riemann hypothesis. First, we show that on the critical line, the $\xi(s)$ function (which is then a real function of a single real variable) obeys a special differential equation, such that it satisfies Bombieri's equivalence condition. Then, since we have been unable to locate the original proof of Bombieri's equivalence theorem, we independently provide a proof for the sufficiency part of it. Namely, if the $\xi(s)$ function satisfies Bombieri's equivalence condition on the critical line, then by the Cauchy-Riemann equations, it has no zeros outside this critical line. Thus, we can conclude that the Riemann hypothesis is true. Finally, we comment on P\'olya's counterexample against using the simplified $\xi(s)$ function to study the Riemann hypothesis, noting that it violates Bombieri's equivalence theorem.


The present article shows the results of a survey presented as Final Paper from the Physical Education class at Centro Universitario Feevale in the year 2005. The investigated matter was: "What are the expectations from private high school students related to contents and practice to be performed in the physical education classes?"  The main goal here was to learn and understand High School students' perception about the activities and contents developed on the physical education classes, for helping in teaching practice. This survey was based on qualitative, interpretative, descriptive pattern and case study. The tools used to collect the data were: class observation, semi-structured interviews, field reporting and document analysis. The survey was accomplished in a private school in Taquara, Rio Grande do Sul, Brasil, with the cooperation of some High School students. The results showed that students expect to have physical education classes directed to the development of fitness for sports and they show their expectations concerning to class organization, methodology and professional teacher performance, activities and contents to be developed in high school classes.


A new device for measuring liquid level has been studied in this paper.By using photoelectric sensitive cell and anti jamming circuit interference of background lights and Hertzian waves was effectively avoided weak signals were amplified by amplificatory and rectifying circuit,and the fluctuation by approach of distilled water to the appointed position was well controlled by comparing circuit.Experimental results showed that this device is of no pollution,highly sensitive and easily controlled.


Ultraviolet (uv) irradiation of Balb/c mice with FS40 sunlamps causes a systemic suppression of contact hypersensitivity (CHS) to trinitrochlorobenzene (TNCB) and dinitrofluorobenzene (DNFB) .l We have investigated Fame of the photobiological and immunological characteristics of this effect and compared them to the previously reported characteristics of uv-induced suppression of tumor Mice were irradiated with a subcarcinogenic dose (2-20 J m-?) of uv on the shaved dorsal skin and afterwards sensitized on the shaved abdomen. C H S was determined five days later by the measurement of ear swelling 24 h after challenge. Animals sensitized one day after uv responded normally, but sensitization 3-15 d after uv resulted in about 70% suppression of the response. C H S returned to normal levels about 21 d after irradiation. Irradiation of unshaved mice required 14 times more energy for 50% suppression than that required for shaved mice, suggesting that the exposed skin is the primary target for this effect. The suppression of CHS was proportional to log,,, of the dose and was unaffected by dose fractionation over a five-day period or by changes in dose rate over a ten-fold range. Elimination of wavelengths below about 315 nm with a Mylar filter abrogated the suppressive effect of the sunlamps, even when the same dose was administered. Contact sensitization of uv-irradiated, but not unirradiated, mice induced the appearance of antigen-specific suppressor cells in the spleen. These were shown to be suppressor T cells by nylon wool filtration and deletion by anti-Thy 1.2 serum. Similar photobiological characteristics have been reported for the uv-induced suppression of immunity to uv-induced tumors."" Also, immunological characteristics, i.e., a time delay in the expression of the effect after irradiation and the generation of specific suppressor T cells, in this case for uv-induced tumors, are similar. Because of these similarities, a common step is implied on the pathway for the uv-induced suppression of these two effects. There are, however, two differences: 13 times more energy is required to suppress tumor immunity and the addition of exogenous antigen is not necessary for the generation of tumor-specific suppressor cells. Using these observations and the previously reported finding that there is a n antigen-presenting defect in uv-irradiated mice,", a hypothesis for the mechanism of uv-induced suppression is suggested. A photoproduct (which may be soluble) is formed in the skin upon uv irradiation and causes a systemic alteration in antigen presentation such that, when a contact sensitizer is subsequently added, suppression, rather than active immunity, results. In the tumor system, it is suggested that the uv has two functions: firstly, to generate a n antigen presentation defect and, secondly, to generate in the skin a tumor-


Abstract The papers in this special issue have all focused on the extent to which spatial planning systems develop and evolve in different domestic contexts. The contributions indicate that many processes of change are place-specific, time-contingent and sometimes path-dependent. For this reason, each national spatial planning system in Europe is distinct, with its own set of territorial institutions, planning practices and actor constellations. Each of the contributions in the volume has helped to demonstrate that common challenges and driving forces of reform to spatial planning (highlighted in the introduction to this special issue) can have differential impacts in different places, which is often due to the influence exerted by domestic actors in the process of change. Even the impacts of common European debates on spatial planning show a high degree of heterogeneity in the five case studies contained in this special issue (Finland, Greece, Italy, Latvia and Portugal) and provide little evidence to suggest that spatial planning systems are converging.


The objective of the present study was to evaluate eight biochemical and Immunological parameters and comparison their level in the infected and non-infected people. The methodology include two parts biochemical assays included aspartate transaminase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea breath test (UREA), and creatinine, and Immunological parameters included D-dimer, ferritin, interleukin 6 (IL-6), C-Reactive Protein (CRP). The result detected by Cobas e411, Cobas C111 device. Results obtained showed high levels of all parameters of covid-19 patients in comparing with the control group patients, with significant differences (p<0.05). Receiver operating characteristic (ROC) curve showed a high area under the curve for all parameters Area under the ROC Curve (AUC) for all parameters were 1.000, except Patent Cooperation Treaty (PCT) was 0.796) and show high sensitivity for all parameters (sensitivity for all parameters were 100%, except PCT was 75%). The present study was observed significant correlations among the studied of the parameters. ©2022 National Information and Documentation Center (NIDOC)


Apparatus remote access (10) adapted to detect a communications protocol of a device (14) coupled to the apparatus remote access through a cable (16a, 17a, 20a), the apparatus comprising: a connector (12) forming a port to which via cable can be attached Ethernet device (16) or a serial device (17) including the connector (12) a plurality of pins; subsystem autosensing (28) in communication with selected pin of the connector pins (12) and configured to detect the presence of a voltage signal on at least one of the selected connector pins (12) when an Ethernet device or serial device is coupled to the connector (12) through the cable without need to receive a transmission signal from the device specific identification thus indicate the presence of the Ethernet or serial device; and subsystem control logic (30) responsive to the subsystem autosensing (28) for controlling at least one switching element subsystem autosensing (28) to connect the connector pins (12) to the internal components of the apparatus cause the apparatus to communicate with the device using a communications protocol or Ethernet protocol standard, respectively, depending on the type of communications device indicated.


Cytomegalovirus (CMV) retinitis in a kidney transplant recipient is a rare illness with only one other reported case in the literature.. We present a case of a 70-year-old kidney transplant recipient female who presented complaining of decreased vision of her right eye. She was diagnosed with CMV retinitis and started on intravenous ganciclovir. After three weeks of therapy, the patient has had no signs of CMV retinitis.. With only one other previous case report of CMV retinitis in a kidney transplant patient, appropriate treatment and predictability of recurrence are unknown.


Cognitive radio (CR) rises up one of the most talented technologies to solve the spectrum allocation problem and improve utilization of the radio spectrum resources, since communication technology expands its province and demand for radio resource has been increasing rapidly nowadays. In the CR home networks, CR devices must leave the current channel and re-connect to the other channel if incumbent user appears on the current channel. For that, it is important to quickly organize a new network or join to new network. Therefore, we propose an efficient method to minimize the initial access time for wireless distributed beaconing network with cognitive radio capability. Our mechanism efficiently helps to minimize the initial access time regardless of whether there is a beacon collision or not.


In any attempt to appraise the doctrines represented in the activity movement-as, in fact, any doctrines-it is well to state the assumption concerning the task and province of education on which the appraisal is based. This assumption is that the business of education may be comprehended under the two broad heads of (i) adaptation, or adjustment, and (2) integration, or development. Both are essential and of equal rank. Adjustment has reference to the external world of persons and things. A person has to adjust to the world by avoiding dangerous or unpleasant objects or actions, by obtaining food and other desirable things, by building and constructing, and by getting along with people. Integration and development refer to the internal condition of the organism. It may take place at the level of the, vital processes, such as breathing, heartbeat, and digestion, or at the level of the learned activities. In fact, learning is, in part, a process of achieving integration. Finally, integration may be represented in the realm of the emotions. Adjustment is brought about by means of agencies which are relatively specific in their nature, though not necessarily immediate. In fact, adjustments may be preparatory and relatively remote. The child acquires immediate adjustment when he learns to feed or to dress himself. He achieves remote or preparatory adjustment when he learns to read or write, in part so that he may carry on vocational or recreational activities as a youth or an adult, or when he learns to play the piano so that he may give public performances later on. Integration, on the other hand, depends not so much on what a person does as on how he does it. What he learns is of prime importance in his adaptation to his environment. How thoroughly he has learned and how smoothly and efficiently he can perform an 655


The work presented in this article is focused on the RF measurement campaign carried out in several subway tunnels in Metro Madrid (Spain). Most common segments such as straight lines, curves and passing through station as well as other unique scenarios in metropolitan lines were the selected locations during this campaign. Measurements were conducted in tunnels of diverse cross section shapes and taken at three frequency bands: 900 MHz, 2.4GHz and 5.7 GHz for both horizontal and vertical polarization.


nos de como a em à segurança do trabalho para os funcionários e das para o abordados ABSTRACT: SPT test is the method most used around the world for soil investigation, however it has several sources of uncertainty in its results. Therefore, an alternative to reduce some of these sources of uncertainty is the use of equipment with automatic hammer. Hence, the present work aims to present some of the resulting effects from the use of automated SPT equipment. For this purpose, records of the hammer drop height were made with a 4K (2160p) 30fps camera, as well as field observation of both methods. Results indicate greater homogeneity in drop height values of the automatic hammer equipment, added to smaller dispersion and average value closer to the brazilian standard (of 75cm). Furthermore, the automatic hammer method presents advantages in aspects related to occupational safety for employees and team optimization (reduction of one employee). In short, the studied aspects in this research reinforce the need for greater attention to the automated SPT method in the national scenario.


Despite the large number of tests currently available to screen potential anti-inflammatory and antirheumatic drugs (Swingle, 1974) there are very few based on leucocyte migration into inflammatory exudates. The implanted sponge technique (Saxena, 1960) seems worthy of more general use since it is a simple procedure, allows a variety of measurements to be performed on exudates at various time intervals after implantation and is suitable for the assessment of inhibitory effects on granuloma formation (FordHutchinson, Smith, Elliott, Bolam, Walker, Lobo, Badcock, Colledge & Billimoria, 1975; Wiener, Wiener, Urivetzky, Shafer, Isenberg, Janov & Meilman, 1975; Clarke, Vernon-Roberts & Currey, 1975). The method may be of particular value in the assessment of substances which interfere with either the formation or action of leucotactic factors derived from complement since rats depleted of complement components by purified cobra venom factor showed a marked inhibition of cellular migration into the sponge exudate (Wiener, Lendvai, Rogers, Urivetsky & Meilman, 1973). Some applications of the sponge method to the study of the sites of action of conventional antirheumatic drugs and the relationship between the involvement of blood platelets, leucotaxis and prostaglandins in the inflammatory exudates will be presented.


Rod lens and method of manufacturing thereof. A fusion glass (1) and a support glass (2) or a support (3) metal are heated in such a way that only the molten glass (1) melts and a spherical cap is formed which constitutes a lens element (10) connected to a light guide member (20). Several rod lens can form a matrix arrangement.


Grammar teaching is the most important constituent and the main means to cultivate students' language competence in foreign language teaching.In the essay,the author first clarifies the importance and necessity of grammar teaching in English major of normal college from the two aspects of language learning and demands of students' future occupations.Then,he points out and analyzes the problems of teachers and students' misunderstanding of grammar teaching and learning,lack of teaching periods,no good coursebook and teachers' outdated teaching methods and students' weakness in grammar.According to the analyses of the problems in English teaching of normal college,the author puts forward a series of reform measures and carries them out in his teaching.Through the countermeasures,he points out that most of the students have become more interested in English grammar,gained more knowledge of grammar,and become more efficient in language learning.They have got more sastified with the reform of grammar teaching,which proves that the reform of grammar teaching is successful.


The purpose of this paper is to reconsider the concept of Bolshevism and its relation to the concept of radicalism during the May Fourth Movement period by looking at the writings on Bolshevism and radicalism in the May Fourth Movement journals. The relevance of different views on radicalism lies in their usages in making claims about possible and desirable set of ideas for the future course of China. Authors such as Chen Duxiu, who wanted to support the idea that China should follow Soviet Russian examples in its development, wanted to give the concept of Bolshevism positive meanings. What made these efforts difficult, was that in this context one of the names, namely guojīzhŭyi (過激主義), which was used to refer to Bolshevism, was also used to refer to the concept of radicalism. This paper shows how many of the May Fourth Movement authors wanted to use alternative names without such negative connotations, such as the one that was based on the phonetics (布爾塞維克, Buěrsāiweike) or semantics (Bolsheviks as 多數派, Duōshupai, the majority party) of the original Russian version (большевики). Authors interested in Bolshevism saw the name guojīzhŭyi as an attempt to denigrate Bolshevism. This paper also shows that neither Bolshevik nor anti-Bolshevik propaganda did not manipulate May Fourth Movement authors. They followed international discussion and were well aware that Bolshevism was a controversial issue abroad.


Health education of tuberculosis(TB)plays important role on TB control in China,and the individual's knowledge of TB could take great impact on the effect of TB control.Four counties with different economic development levels were randomly selected in Shandong Province,and in each county,the rural TB patients who registered in the county TB Dispensary and have completed the DOTS treatment were enrolled in the study,total 404 rural patients were finally investigated in the four counties.And the patients were investigated by household survey method with structured questionnaires.This paper analyzes the knowledge of TB of Shandong rural TB patients,and studies the relationship between the regular treatment behavior and knowledge of TB.The results show that the knowledge of TB is not optimistically,16% of TB patients still didn't know the infectivity of TB,and 15% of TB patients didn't believe TB is curable.Even most of TB patients knew the free treatment policy,almost of them didn't say the detailed contents of policy,they just heard about it.The female and illiteracy TB patients had poorer knowledge of TB.The patients who believe TB is curable and know the free treatment policy had more possibility to keep the drug-gotten behavior regularly.It is recommended that the health education of TB should focus on key target population,pay more attention on the basic knowledge of TB with easily understanding and acceptable formats.In particularly,setting up the belief of the curability of TB among patients is very important to improve the effect of TB control.


Using the multi-layer perceptron model to analyze the data of 205 convenience stores in Chengdu, explore the influence of customer daily flow, customer preferences and convenience store purchase channels on the willingness of community convenience stores to transform under the new retail trend. Customer preferences and convenience store purchase channels will have a significant impact on the willingness of community convenience stores to transform, based on this, to provide guidance for the transformation and development of community convenience stores. 新零售趋势下社区便利店转型影响因素研究 汤韵1,a,*, 周林2,b, 李汶蔚3,c 1 四川农业大学电子商务系,都江堰,成都,四川,中国 2四川农业大学电子商务系,都江堰,成都,四川,中国 3四川农业大学会展经济与管理系,都江堰,成都,四川,中国 firstname.lastname@example.com, email@example.com, firstname.lastname@example.com


Sir,

In contrast to the reported poor prognosis of haemodialysis patients, the article by Heaf et al. [1] published in a recent issue of Clinical Kidney Journal reports the remarkable long-term survival of one such patient. We too have a similar story and can confirm that long-term survival is entirely possible. This may offer hope and allay the fears and depression that accompany the prospect of life-long dialysis.

Our patient was a woman, born in 1944, who started treatment at the age of 26 for end-stage renal disease due to glomerulonephritis. Our patient received a kidney transplant in 1981, but unfortunately this did not function and she was never able to discontinue dialysis, even for one treatment session. The graft was ultimately removed after 1 week.

Like Heaf et al.'s patient, ours underwent total parathyroidectomy with reimplantation in her right forearm, and calcium and PTH levels are now under control with 1 μg calcitriol weekly. What is even more remarkable is that her arterovenous fistula, which was inserted when she first started dialysis, is still working perfectly and is still used to administer treatment three times a week without any problems or signs of malfunction.

Despite severe arthropathy and coronary artery disease (she has refused coronary angioplasty), her quality of life is good since she is reasonably independent in her everyday life and still lives at home with her husband.

In September 2012, our patient celebrated 40 years of uninterrupted dialysis treatment with the entire dialysis staff, and an article appeared in a local paper to commemorate the event (http://ricerca.gelocal.it/tribunatreviso/archivio/tribunatreviso/2011/09/28/TP5PO_TP505.html). Interestingly, our patient has demonstrated the two essential qualities mentioned by Heaf et al.: 'good compliance and a will to live'. In our opinion, it is important that these cases are made known, to demonstrate that although it may not be the rule, it is possible to survive for such long periods of time on dialysis and experience a good quality of life.


In the last decade, social network analysis (SNA) tools have gained considerable interest in intelligence and security communities, as terrorist networks have become more global, decentralized, and flexible. Additionally, recent concerns have been voiced that virtual worlds provide likely breeding grounds for terrorism recruitment, communication, and coordination activities. This paper outlines research involving a survey of the approaches criminal or terrorist groups can take to covertly advance their causes in virtual environments. In addition, a methodology for collecting, storing, and analyzing information about virtual world cyber-behaviors is presented. As an initial effort, data collection devices were created in the virtual world Second Life (SL). These devices are capable of recording a variety of behavioral data about avatars in SL, and then piping that information to an external database. Information from the database can then be analyzed using SNA. Preliminary results indicate that a combined approach utilizing manual and automated intelligence techniques along with SNA provide valuable insights into the structure, function, and key players within virtual world social networks.


Image enhancement is a crucial pre-processing step in almost every medical imaging system. Different types of degradation can occur in medical images such as noise, blur and contrast imperfection. Filtering techniques have been successfully applied for denoising and deblurring images, while contrast enhancement has been achieved using histogram equalisation. This technique has the main drawbacks of losing details included in minor grey levels or over-enhancement. As a solution, the grey-level mapping technique has been adopted. Defining the new set of grey levels, to substitute those of the input image, using an exhaustive search is computationally complex; so metaheuristics are generally used. In this topic, this paper presents a new opposition-based firefly algorithm to search the best target set of grey levels for medical image contrast enhancement. The obtained results are compared against those obtained by histogram equalisation and classical variants of the firefly algorithm.


This digest summarizes proposed design guidelines for reducing hydroplaning on new and rehabilitated pavements developed in NCHRP Project 1-29, "Improved Surface Drainage of Pavements." This digest was prepared by R. Scott Huebner, David A. Anderson, and John C. Warner of the Pennsylvania Transportation Institute. The complete project report is available as NCHRP Web Document 16 at Internet address http://www4.nas.edu/trb/crp.nsf (click on Web Documents).


In a previous column (Physics Today, September 2005, page 10), I described how computer models might be used to mimic and describe a few of the small networks that control and drive biological systems. I focused upon the understanding that could be obtained from moderately accurate descriptions of relatively simple biological systems. Here, I wish to look at conceptualizations of much larger networks.


With the increasing interest in dark matter axion detection through haloscopes, in which different international groups are currently involved, the RADES group was established in 2016 with the goal of developing very sensitive detection systems to be operated in dipole magnets. This review deals with the work developed by this collaboration during its first five years: from the first designs—based on the multi-cavity concept, aiming to increase the haloscope volume, and thereby improve sensitivity—to their evolution, data acquisition design, and finally, the first experimental run. Moreover, the envisaged work within RADES for both dipole and solenoid magnets in the short and medium term is also presented.


Using data from Cycles 17, 18, and 19, we have updated the IR channel bad pixel table for WFC3. The bad pixel table contains flags that mark the position of pixels that are dead, unstable, have a bad zeroth read value, or are affected by "blobs". In all, 28,500 of the science pixels (2.77%) are flagged as bad. Observers are encouraged to dither their observations as a means of lessening the effects of these bad pixels. The new bad pixel table is in the calibration database system (CDBS) as w681807ii_bpx.fits.


P011 Imaging without a velocity model by pathsummation approach: this time in depth 1 Abstract In this paper we generalize a method proposed for model independent time imaging to calculate seismic images in depth without performing velocity analysis or using a priory knowledge of the exact subsurface model. By analogy to the use of Feynman path integrals in waveform modeling we develop an algorithm for depth imaging by summation of elementary signals over a sample of all possible paths between source and receiver. The constructive and destructive interference of these signals produces an image of the subsurface. Introduction It is


A large ascending Aortic pseudoaneurysm is a rare life threatening complication after off pump coronary artery bypass surgery. We herein describe such a case of massive ascending Aortic pseudoaneurysm, with impending rupture which was adherent to undersurface of sternum, was successfully treated by us at Square Hospitals Limited.
Bangladesh Heart Journal 2022; 37(1): 72-76


 Abstract— Cloud computing is a set of technologies that allows computing applications and data to be exposed as a set of services from a pool of underlying resources. It provides development environment, allocation and reallocation of resources when needed, storage and networking facility virtually. Cloud Computing is access to massive computing power and storage resources on demand to customers. This paper highlights the problem of ensuring confidentiality and integrity of data stored in public cloud. A user can access cloud service as a utility service. Cloud Computing involves storage of user data in cloud which enables user to throw data in cloud without worrying about how it is stored or backing it up. This paper focuses on achieving user control data storage framework by providing a cryptographic security service and storage service in document centric public cloud applications. In particular, we proposing a framework in which user have full control over its data by implementing an AES symmetric encryption technique for achieving data confidentiality and HMAC technique for checking integrity of stored data in cloud.


In order to seek a kind of simple,rapid,accurate determination of sulphur in recarburizer,high-frequency combus tion-infrared absorption method was used.Tests show that the optimum proportion of flux is 0.5 g pure iron+0.050 g sample+0.3 g tin pellet+1.5 g tungsten.The suitable sample is the interlayer in mixed flux,using coke as a reference material,the test results are accurate and reliable.The analytical result for practical samples meets the requirement.


The study of the La(1‐x)BixMnO3 system is conducted using X‐ray diffraction (XRD) and electrical measurements. A continuous solid solution is evidenced for the LaMnO3 rich part of this system (x ≤ 0.6). According to the analyses of XRD results, a rhombohedral symmetry ( R3¯c ) is observed for x ≤ 0.4 and a cubic structure for x = 0.5. The structural study allows to determine an increase in the mean perovskite lattice parameter, together with a decrease in the rhombohedral angle up to a cubic symmetry for x = 0.5. For x > 0.6, the system is no more single‐phased. Impedance measurements are conducted for ceramics in a wide‐frequency range (100 Hz–1 MHz), between room temperature and 800 °C. The exponential decrease in the alternative current (AC) conductivities (σAC) and the room temperature values correspond to a semiconducting behavior. Direct current (DC) conductivity measurements (σDC) are also performed below room temperature (25 K < T < 300 K). The results evidence for a metal–insulator phase transition. For the exponential part of the σDC curves, the gap energy is between 0.1 and 0.2 eV, confirming the semiconductor behavior of these materials.


Rectangular collimation has proven to reduce the radiation dose to the patient as well as increase image quality. Studies have been conducted in the past to determine whether utilization of rectangular collimation results in a greater retake rate, however, there is a lack of data regarding the amount of rectangular collimation devices that are currently in use. The purpose of this study was to determine to what extent, if any, rectangular collimators are being utilized in dental and dental hygiene programs. A survey was created and sent via email to the program directors of Accredited dental and dental hygiene programs. A total of 97 programs responded to the survey, however 16 of those surveys were not completed. To be included in the data analysis, question number one (which program do you represent, dental or dental hygiene) must have been answered. Eighty-nine responses qualified, of those, 6 were dental programs and 83 were dental hygiene programs. The results determined that the majority of the programs teach about rectangular collimation in the didactic portion of the radiology course, but do not use a rectangular collimation device during patient care.


The recent environmental interests and concerns have an effect on the entire vehicle industry. Since the regulations like limiting the emission of greenhouse gases take into effect, people are more interested in green vehicles such as hybrid vehicle, electric vehicle, and fuel cell vehicle for they emit less greenhouse gases than conventional vehicle. Especially, hybrid vehicle is the most commercialized vehicle among green cars. The maximum velocity and the acceleration characteristic of a vehicle are important factors to figure out the performance of the vehicle. Driving real vehicle adjusting parameters like mass, frontal area, etc. may be accurate. However, this method costs highly and readjusting parameters may take too much time. So using programs and simulating the vehicle model may save time and money. In this study, hybrid vehicle will be modeled using MATLAB Simulink and the dynamic characteristics of the vehicle will be figured out considering some conditions. The type of hybrid vehicle model will be 6-wheel series hybrid combat vehicle using In-Wheel motor. The forces acting on the vehicle were calculated to figure out the dynamic characteristics of vehicle. Tractive force from each motor in each wheel can be calculated and resistive force such as drag resistance, rolling resistance, and slope resistance can also be calculated. After calculating net force on the vehicle, instantaneous acceleration and velocity can be obtained. The maximum velocity of the vehicle can be calculated when the resistance force and tractive force are equal during process of feedback of instantaneous velocity. If there are errors between characteristic of Simulink model and real model, discussions will be added.


The removal of mercuric chloride and methylmercury from a culture medium and a fi sh broth was examined by using methylmercury-volatilizing Alteromonas strains isolated from the seawater of Minamata Bay. The highest removable concentrations for the bacterial volatilization of mercuric chloride (HgCl ) and methylmercuric chloride (CH HgCl) were μg/ml and μg/ml, respectively. The maximum volatilization percentages for μg/ml HgCl and μg/ml CH HgCl were . and . , respectively. The volatilization percentages for CH HgCl by these strains were signifi cantly higher than those for HgCl . The removal of methylmercury in the fi sh broth was examined with a laboratory column packed by methylmercury-volatilizing Alteromonas macledii strain immobilized with -carrageenan beads. More than % of mercury was removed from the fi sh broth containing μg / ml of methylmercury in hrs. It seems that the immobilized cell application is eff ective to remove methylmercury from a drainage of fi sh processing


In the 1990s, Belarusian media space saw an influx of translations from multiple languages into Russian or Belarusian. This particularly included textbooks, as locally-written up-to-date textbooks for higher educational institutions simply did not exist in many fields. Today, higher education still sees a high rate of translated books; however, currently these translations are largely from Russian or Belarusian into English or other languages. This is due to two factors: foreign students coming to study in Belarus and the educational system introducing programs in English alongside programs taught in Russian. To supply these new programs, textbooks and other learning materials are being actively translated into English.


Abstract Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with Escherichia coli CGMCC 11674 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The FEEDAP Panel issued an opinion in 2019 in which they could not conclude on the safety of the additive for the target animals and for the consumer due to tryptophan‐related impurities such as 1,1′‐ethylidene‐bis‐l‐tryptophan (EBT). The applicant submitted additional data and the European Commission (EC) has requested EFSA to deliver a new opinion on the safety of the additive under assessment. The manufacturing process has been adjusted to reduce the amount of tryptophan‐related impurities and the analysis of three new batches of the additive indicated that levels of EBT and 1‐methyl‐1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (MTCA) represent no safety concerns for the target species or for the consumer.


The mobile-bearing variant of a single-radius design is assumed to provide more freedom of motion compared to the fixed-bearing variant because the insert does not restrict the natural movements of the femoral component. This would reduce the contact stresses and wear which in turn may have a positive effect on the fixation of the prosthesis to the bone and thereby decreases the risk for loosening. The aim of this prospective randomized study was to evaluate early migration of the tibial component and kinematics of a mobile-bearing and fixed-bearing total knee prosthesis of the same single-radius design. According to a prospective randomized protocol 20 Triathlon single-radius posterior- stabilized knee prostheses were implanted (9 mobile-bearing and 11 fixed-bearing). Fluoroscopy and roentgen stereophotogrammetric analysis were performed 6 and 12 months post-operatively. The 1 year post-operative roentgen stereophotogrammetric analysis results showed considerable early migrations in 3 mobile-bearing patients and 1 fixed-bearing patient. The range of knee flexion was the same for the mobile-bearing and fixed- bearing group. The mobile insert was following the femoral component during motion. This study showed no apparent distinction in early migration and kinematics between mobile-bearing and fixed-bearing single-radius total knee prostheses. Des- pite the mobile insert was following the femoral component during motion, and therefore performed as intended, no kinematic advantages of the mobile-bearing total knee prosthesis were seen. It is concluded that a mobile insert in single-radius total knee prostheses is redundant and will not lead to additional benefits.


Objective: To observe the clinical outcome and the effect of bone metabolism of cinacalcet combined with calcitriol in maintenance hemodialysis (MHD) patients with severe secondary hyperparathyroidism (SHPT). Methods: Thirty MHD patients with SHPT were enrolled into the study. All patients were given cinacalcet 25–75 mg and 0.5 μg calcitriol daily. Serum Ca, P, intact parathyroid hormone (iPTH), and bone metabolic markers were measured. The clinical symptoms and their changes were investigated. Results: The baseline levels of iPTH, Ca, and P were 1,787.3 ± 1,321 pg/mL, 2.54 ± 0.19 mmol/L, and 2.06 ± 0.15 mmol/L respectively. After 3 months treatment, iPTH decreased by 70%. Serum Ca and P fell to 2.39 ± 0.17 and 1.56 ± 0.50 mmol/L (p < 0.05), respectively. After 6 months, the bone-specific alkaline phosphatase, osteocalcin, and β-cross levels were decreased by 50, 37, and 49% respectively compared with corresponding values before treatment. A decline in the bone density patients was inhibited. Conclusion: Cinacalcet combined with low dose calcitriol can improve high calcium, high phosphorus, and high iPTH in MHD patients with severe SHPT and also improve bone metabolism. It can be used as a favorable choice for SHPT treatment.


Experimental evidence indicating that many conversion coefficients for enhanced E2 transitions between rotational states are not in agreement with theoretical values is given. Discrepancies are correlated with the ratio of neutrons to protons in the nucleus. (L.N.N.)


A method of picking up carbon nanotubes (CNTs) from nanotube bulk by van der Waals force inside a scanning electron microscopy is presented. An atomic force microscope cantilever was employed as end effector of nanorobotics manipulators for CNT picking up. A manipulation strategy was established by analysing the van der Waals force of three different types of contacting models. Three groups of experiments were designed and carried out to investigate the effects of different factors. Factors including pickup angle, pickup contact area between the CNT and the cantilever and pickup speed of the end effector were discussed. The results shown that a pickup angle at 90.1° and a pickup speed lower than 10 nm/step with a pickup contact length more than 1.5 µm would increase the probability of picking up CNT successfully.


Graphical and experimental methods exist for the determination of the local shearing stress and heat flux on the boundary of a duct of constant cross section in a fully developed turbulent flow. While the graphical method (see for example Ref. 1) is simple to effect, the premise on which it is based is questionable and even so a high order of drawing accuracy is necessary for reliable results. In the graphical method, it is assumed that there is no turbulent stress on surfaces which are perpendicular to the w-velocity contours (see Fig. 1). The shearing forces on the elemental area which is subtended at the boundary are then equated to the difference between the pressure forces acting over the elemental area of the duct cross section. This is a clever technique, but the use of surfaces across which the w-velocity gradient is zero for the calculation of the boundary stress needs more justification. Similarly, for heat flux distribution by a graphical method, it is difficult to determine the planes in the duct across which there is no turbulent heat transfer. As for the stress, surfaces across which there is no temperature gradient are not necessarily coincident with surfaces of zero heat flow. For the experimental determination of the wall stress, the ingenious Preston tube is available, but for the heat flux there is no simple counterpart. Heat meters (and their associated instruments) which are sometimes used are difficult to manufacture and their data must be treated with care.


Health is generally thought of as the absence of disease or physical infirmity. However, a great number of scientific studies show that there is an interdependence and interconnectedness between the physical, mental, spiritual and social dimensions of the human being. Consequently, there needs to be an emphasis on giving treatment and care to the whole person. This article proposes that a biblical understanding of the Hebrew word shalom provides a basis for emphasizing the need for health care beyond physical wellbeing. It also highlights some practical ways that Christians can contribute to meeting global health needs from the perspective of biblical human wholeness.


Based on the investigation of the disastrous fire accident in Daqing city on March 8, 2004 when 17 vehicles were burned, the seat and origin of fire were determined with the help of fire patterns and characteristics.The fire cause was finally analyzed and determined by using the remanence method even there is no melt drop and no residues.The conclusion for the investigation was consistent with the confession of the suspicion.


In recent years, various disasters have taken place frequently, and then highway blocking has happened from time to time. In order to be open to traffic as soon as possible, the project management should take the corresponding measures not consistent with the normal construction. This paper mainly studied the project management of urgent repair of highway after disaster(This paper uses "this kind of project"), analyzed the characteristics of urgent repair of highway after disaster, main tasks of project management, and proposed the measures to improve the ability and level of project management of this kind of project based on the actual situations and project management experience, so as to perfect the this kind of project and create greater benefits for people.


Guided by the theories of system theory, synergetic theory, and other disciplines and based on fuzzy data mining algorithm, this article constructs a three-tier social security fund cloud audit platform. Firstly, the article systematically expounds the current situation of social security fund and social security fund audit, such as the technical basis of cloud computing and data mining. Combined with the actual work, the necessity and feasibility of building a cloud audit platform for social security funds are analyzed. This article focuses on the construction of the cloud audit platform for social security funds. The general idea of using fuzzy data mining algorithm to build the social security fund audit cloud platform is to compress the knowledge contained in a large number of data into the weights between nodes and optimize the weights through the learning of the neural network system. Through the optimization function, the information contained in the neural network is stored in a few weights as far as possible. The main information is further highlighted by network clipping and removing weights that have little impact on the output.


The paper presents issues related to the electromagnetic compatibility of a plasma reactor. A diagram of a gliding arc discharge plasma reactor's column and its power system are presented, as are the measuring system and the preliminary voltage measurement results of conducted electromagnetic disturbance on the power lines of the plasma reactor in question.


Background: Cornelia de Lange syndrome is a rare syndrome of highly variable phenotype making a spectrum ranging from classic syndrome with many cardinal features to mild condition few cardinal features. Typically patients with classic syndrome had growth and mental retardation and distinctive facial dysmorphism including thick (bushy) and / or long eyebrows commonly with synophrys, short nose with depressed or concave nasal bridge and/or upturned nasal tip , long or smooth or indistinct philtrum, thin upper lip vermilion and/or downturned corners of mouth, and low set ears. The diagnosis of the syndrome is clinical. Ocular abnormalities that can be associated with Cornelia de Lang syndrome squint, nystagmus, refractive errors, and ptosis. Materials and methods: The occurrence of Cornelia de Lange syndrome has not been reported or well-documented. The first four Iraqi patients (Three boys and one girl) with Cornelia de Lange syndrome are described. The relevant literatures were reviewed with aim of determining the early documentation of the syndrome in the medical literatures. Results: All the patients were sporadic cases and had growth retardation, severe mental retardation with significant developmental delay, thick eye brows with some degree of synophrys, short nose with depressed or concave nasal bridge, and low set ears. All the patients had normal karyotype. One male patient had all of the classical features including long smooth and indistinct philtrum, thin upper lip vermilion, and downturned corners of mouth. The second male patient had a concave nasal bridge that becomes more obvious during crying, nystagmus and bilateral convergent squint. The third boy had milder dysmorphic features. The fourth patient was a girl who was the second of a twin. She had severe growth retardation and was hypotonic with poor head control. She also had bilateral convergent squint, refractive error, and reduction in visual acuity. Conclusion: The first four Iraqi patients with Cornelia de Lang syndrome are reported.


The paper made routine inspection for the three simply supported steel bridges which are city's main thoroughfares for years,and found that the bridge vibration amplitude was large as well as the injury site of steel box girder all started from the deck pavement.Therefore,by the investigation of traffic flow,this paper made analysis checking to the structural section and local stress concentration section,at the same time conducted random sampling for the physical and chemical properties of steel sheet base material,made ultrasonic testing of the plate thickness,plate surface cracks,welds,etc.,analyzed the cause and then evaluated the strength and stiffness of the structure by load test.


Feeling out of the loop is a common experience that people have. This research shows that feeling out of the loop lowers people's sense of control and power. More interestingly, to overcome this lack of power, people are more likely to take action after feeling out of the loop. They are also more likely to make first offers in negotiations after feeling out of the loop.


This article proposes a methodology for enabling Unmanned Aircraft Systems (UASs) to avoid obstacles. The strategy, which makes use of a Robust Exact Differentiation (RED), relies on spiral trajectory tracking maneuvers, and is based on a backstepping controller with disturbance compensation. The RED strategy has been adopted since it enables the exact estimation of disturbances from the first moment, a characteristic that may be useful for real-time UAS operations in environments with obstacles. Our research concentrates in one of the main components of a Sense and Avoid (SSA) system, specifically, conflict resolution, leaving as future work the sensing aspect. To demonstrate the performance of the proposed solution, we present a set of simulation results as well as a real-time experiment where a holonomic UAS makes use of the estimation and control strategy while evolving in an environment with obstacles.


The fatigue and corrosion fatigue lives of S135 drill pipe steel were tested in air and in a simulated marine environment. The empirical equations for fatigue lives in different environments were obtained via regression analysis, and fatigue fracture mechanisms were elucidated. Results showed that an endurance limit existed in air, and fatigue cracks were initiated from or near the surface of specimens. The morphologies in air were cleavage fracture at the crack initiation zone and fatigue striations at the crack propagation zone. In the marine environment, fatigue striations were less at higher stress amplitudes, and fatigue lives were lower than that in air. Fatigue cracks were initiated from the corrosion pits on and near the surface of specimens. The morphologies were characteristic cleavage fracture at the crack initiation zone and cleavage fracture and secondary cracking at the crack propagation zone. Less fatigue striations occurred on the main fracture surface. The fracture mechanism in the marine environment can be summarized as follows: corrosion pit formation, crack initiation, crack propagation, piercing, and fracture.


A small group of academics and practitioners discuss the challenges now facing today's business schools. First and foremost is the challenge now being mounted by "online" courses to the traditional methods of classroom lecture and discussion, supplemented in some cases by apprenticeships and other kinds of "experiential" learning. How will traditional universities burdened with high and rising fixed costs for buildings and faculty compete with very low‐cost competitors - programs that reportedly have enabled star lecturers to reach audiences that, in some cases, have exceeded 100,000 students?. In assessing the seriousness of the challenge, the panelists start by attempting to articulate what is valuable in current business school education - valuable enough to enable the best business schools to command as much as $175,000 for two‐year (or shorter) programs that confer MBAs. Much of the discussion focuses on establishing the relative importance of the disciplines, or body of knowledge, that are taught in business schools, as compared to the development of "collaborative" habits and interpersonal skills aimed at enabling students to make more effective use of their knowledge within large organizations. Some of the panelists, notably Jeff Sandefer, founder of the (now ten‐year old) Acton School of Business, argue that far too much of today's business school curriculum is devoted to the classroom and conventional learning. And many of the changes in the top business schools during the past decade appear to reflect Sandefer's charges. But, to the extent there is a consensus among the other panelists, it is that the best business schools will continue to try to accomplish both of these goals, though with varying degrees of effectiveness, while most schools attempt to maintain their specialized capabilities, and carve out distinctive niches based on them. For some schools, such specialization is likely to mean continued emphasis on theory and classroom learning - though almost certainly with more attention to practical application and collaborative decision‐making. For other schools, the main focus will continue to be the development of general management and leadership skills.


Fine particulate matter (PM2.5) has a serious impact on human health. Forecasting PM2.5 levels and analyzing the pollution sources of PM2.5 are of great significance. In this study, the Lagrangian particle dispersion (LPD) model was developed by combining the FLEXPART model and the Bayesian inventory optimization method. The LPD model has the capacity for real-time forecasting and determination of pollution sources of PM2.5, which refers to the contribution ratio and spatial distribution of each type of pollution (industry, power, residential, and transportation). In this study, we applied the LPD model to the Beijing-Tianjin-Hebei (BTH) region to optimize the a priori PM2.5 emission inventory estimates during 15–20 March 2018. The results show that (1) the a priori estimates have a certain degree of overestimation compared with the a posteriori flux of PM2.5 for most areas of BTH; (2) after optimization, the correlation coefficient (R) between the forecasted and observed PM2.5 concentration increased by an average of approximately 10%, the root mean square error (RMSE) decreased by 30%, and the IOA (index of agreement) index increased by 16% at four observation sites (Aotizhongxin_Beijing, Beichenkejiyuanqu_Tianjin, Dahuoquan_Xintai, and Renmingongyuan_Zhangjiakou); and (3) the main sources of pollution at the four sites mainly originated from industrial and residential emissions, while power factory and transportation pollution accounted for only a small proportion. The concentration of PM2.5 forecasts and pollution sources in each type of analysis can be used as corresponding reference information for environmental governance and protection of public health.


&NA; The aim of our study was to evaluate the correlation between skin thickness and bone mass with a view to eventually using this parameter as a clinical screening tool to identify women with possible low bone mass in whom a more costly diagnostic test, such as x-ray radiometry, should be performed. One hundred and ten women who were scheduled for osteodensitometry were invited to participate. Skin thickness was measured with a mechanical calliper. Bone mineral density (BMD) was measured at the lumbar spine (L2-4) and at the femoral neck levels by dual energy x-ray absorptiometry (DXA). The Pearson's correlation coefficient obtained between skin thickness and lumbar spine BMD was 0.37 (p = 0.0001); between skin thickness and femoral BMI it was 0.33 (p= 0.001). The correlation coefficient between skin thickness and age was ‐0.35 (p = 0.0001) and between skin thickness and body mass index was 0.30 (p = 0.002). The correlation coefficient between BMD values obtained at the femoral and lumbar levels was 0.74 (p = 0.0001). In addition to our results, we present a summary of the data available in the literature on the correlation observed between skin thickness collagen content and bone density. The coefficient of correlation varies greatly among these studies and is not consistently statistically significant. These differences can be explained by the methodologies used by the different authors. Although skin thickness cannot replace BMD in identifying women with low bone mass in whom estrogen replacement therapy is indicated, we think that skin thickness may become a helpful tool in screening women. Further research is needed before clinical recommendations are given.