Due to shared mechanisms of thrombosis and hemostasis, all current anti-thrombotic drugs in clinical use, including anti-coagulant and anti-platelet drugs, are associated with increased bleeding risks, which can be life-threatening. Thus, there is a need for developing new anti-thrombotics that minimally cause excessive bleeding. We have recently shown that integrin outside-in signaling, which plays an important role in occlusive thrombosis but is not required for primary platelet thrombus formation, is mediated via the interaction between integrin [[Unsupported Character - Symbol Font ]]3 subunit and heterotrimeric G protein, G[[Unsupported Character - Symbol Font ]]13. We have developed a novel inhibitor of integrin-G[[Unsupported Character - Symbol Font ]]13 interaction, mP6, which inhibits thrombosis without causing excessive bleeding in mouse models. In this study, we have directly compared effects of an improved formulation of mP6, M2mP6, with current anti-platelet drugs clopidogrel and aspirin on arterial thrombosis and hemostasis. We demonstrate that retroorbital injection of M2mP6 exerted potent anti-thrombotic effect within 5 min compared reported effects of clopidogrel of more than 1 hour. One time injection of M2mP6 (15 min, 5 μmol/kg, retro-orbital) is significantly superior to one-time ingestion of clopidogrel (2 hours, 2 mg/kg, oral) and superior to high concentrations of aspirin in inhibiting occlusive thrombosis using FeCl3-induced mouse carotid artery thrombosis model. Importantly, both clopidogrel and aspirin caused significantly prolonged tail bleeding time. In contrast, M2mP6 injection is not statistically different from control mice in tail bleeding time analysis. Furthermore, M2mP6, when used together with clopidogrel or clopidogrel and aspirin, showed synergistic effect in inhibiting occlusive thrombosis. These data demonstrates M2mP6 can potentially be a fast-acting and potent anti-thrombotic drug that does not cause adverse effect of bleeding.


The article presents dynamic methods for assessing the performance of a tractor unit, substantiates the dependence of transient processes of a tractor in an unsteady mode of operation. The performance of tractor units provides for an assessment of the ability to perform the specified functions that meet the requirements of regulatory and technical documentation. It is proposed to evaluate the performance of the tractor units when its technical condition changes by the magnitude and direction of the deviation of the center of gravity of the real transient process from the reference model. Express methods for diagnosing the steering and braking systems of a tractor are presented. The proposed express method of diagnosing the steering of the tractor allows you to carry out diagnostics with the least amount of time without the presence of a special platform. For diagnosing brake systems of tractors, a new indicator - the growth rate of deceleration - has been proposed as a diagnostic tool


Randomised trials are designed to eliminate systematic error (bias) in the estimate of the effect of an intervention (usually a treatment) through randomised allocation of patients to treatment the intervention with concealment of allocation. In an observational study, no such intervening in the treatment is made and the outcome is merely "observed" along with other relevant information (e.g. pre-operative characteristic of patients). Unless the groups of individuals who receive the intervention and control are similar (or such groups can be created), selection, information and confounding bias will need to be addressed in the statistical analysis.


Polyacrylamide gel electrophoresis (PAGE) is a standard procedure for identifying and analyzing polypeptides (1). Samples are prepared from cell lysates, subjected to electrophoresis and stained with silver nitrate or Coomassie Brilliant Blue (CBB) allowing direct visualization of bands within gels (1,5). Samples can also be radiolabeled, for example with [35S]methionine, and after electrophoresis, the resulting gels are dried on chromatography paper and autoradiographed (3). A wide variety of electrophoresis chambers are available for producing gels for these types of analyses. We describe here a procedure, which allows one to use a nucleic acid sequencing gel apparatus instead of the conventional equipment. The main advantage of this method is that it enables the use of one apparatus for both DNA sequencing and polypeptide work. To prepare a sequencing apparatus before sealing, we used a Sequi-Gen cell (21× 50-cm) (Bio-Rad, Hercules, CA, USA) for carrying out this procedure. The clamp set, which is used to hold the glass plates together, should be in good condition. Warped or uneven clamps cause leakage at the sides during gel pouring. Plates and spacers are washed normally and rinsed with 70% ethanol. No treatment is required to selectively bind the acrylamide gel to the outer glass plate. Four 0.4-mm spacers are required. These are doubled together along each side of the apparatus, giving a gap of 0.8 mm, once the assembly is clamped together. Thinner gels (0.4 mm) are extremely difficult to pour, and they break easily at the plate separation stage. The gap generated by the double set of spacers does not allow for the use of standard 0.8-mm combs for protein gel combs. This is overcome by using the Bio-Rad 14-cm plastic square combs (16 well), which are designed for sequencing. Two combs of 0.4-mm thickness are glued (or can be taped) together to form a single comb, which fits well in the gap made by the spacers. If combs are glued, a high-strength adhesive should be used so as not to increase the width significantly, and the edges of the comb are trimmed with a scalpel after gluing. New combs should be tested before pouring gels. The only other extra requirement is approximately 10 cm3 of modeling clay or plasticine, which is used for sealing the bottom of the assembled apparatus. The plasticine should be kneaded before use to make it very malleable and is split into three lots, two of 0.5 cm3 each and the remainder. The smaller pieces are pressed at the bottom corners of the assembly, over the areas where the ends of the spacers are located. Care should be taken to ensure that this area is completely dry as moisture can inhibit the sealing capacity of the plasticine plugs.


Abstract Songs are one of the rhetoric devices advertisers use to flatter audiences to buy products, services or ideas they might have not even thought of buying. If the scenes of an advertisement are accompanied by well-suited pieces of songs, they become more effective. While songs in advertisements serve various roles ranging from entertainment, increasing product or service memorability and targeting audiences to structure/continuity in the advertisement itself, this article argues that songs in advertisements also have the potential of constructing and negotiating meaning in specific contexts (Cook 1999:39). These specific contexts range from political to commercial advertising, to mention but two. The ultimate aim of this construction and negotiation of meanings in advertisements through songs is the "establishment of authority" (Huron 1989). When authority is established, an organisation's products, services or ideas will command superiority over those of competitors. In order to show how songs in an organisation's advertisement asserts authority of products, services or ideas, three Zimbabwean advertisements will be used as instances. Focus will be on the lyrical language of songs, for it is through these lyrics that audiences' disbeliefs or doubts are overcome and authority established.


This paper demonstrates that FIFTHTM, a new vector-based genetic programming (GP) language, can automatically derive very effective signal processing algorithms directly from signal data. Using symbol rate estimation as an example, we compare the performance of a standard algorithm against an evolved algorithm. The evolved algorithm uses a novel approach in developing a symbol transition feature vector and achieves an impressive 97.7% overall accuracy in the defined problem domain, far exceeding the performance of the standard algorithm. These results suggest that vector based GP approaches could be useful in developing more expressive features for a large class of signal processing and classification problems.


Why is an incidence study so important? In a prevalence study, we can only look at factors associated with the outcome in question. For example, we can see that people with diabetes also tend to have abdominal obesity or limited physical activity. However, we can only point to associations between these different variables. In an incidence study where we follow the same individuals over time, we can move beyond association to causation. We can see which characteristics at time point #1 caused the outcomes in those same people at time point #2. By looking at this, we can also learn what characteristics have predictive value for the outcome of interest. For e.g. we observe that patients of type 2 diabetes also tend to be obese. This data could indicate any of three possiblilties, viz. one, obesity could cause diabetes, two, diabetes could cause obesity and three, the two may be coincidentally found together without their being any causal association. Hence, a prevalence study cannot assert causation; it merely detects associations. Moreover, an incidence study allows us to get a better sense of all cases of an illness. In prevalence studies, we miss severe cases that have recently resulted in death. By sampling at two periods, we can learn about the causes of death of people who die between times #1 and #2.


In this poly-prismatic short study is examined historically and totally the diachronic attempts of an approach of "Absolute being" from the side of thinking man. More specifically it is searched philosophical and theological doubting and seeking for the existence of "Absolute being," as for the – conscious or unconscious – its influences above in human mentality. Also, it is discussed generally if firstly is feasible any approach of " Absolute being " by man. Moreover, the various philosophical-theological and religious-psychological ways of approach of " Absolute being " are recorded as also and how this "approach" is meant. Finally, it is reported the theological perpetual process of approach of "Absolute being" as the profound reasons of this " approach " .


Thermodynamic analysis of parallel flow single and double effect LiBr-H2O absorption system has been carried out. In the single effect cycle, the refrigerant leaving the evaporator is divided to flow in parallel and get absorbed partly in a heat recovery absorber and the remaining in a heat rejecting absorber. This reduces heat load of the generator to a great extent and hence, improves COP of the cycle. Similarly in the double effect parallel flow cycle, the solution leaving the absorber is divided into two parts, one being sent to the main generator and the other to the secondary generator. Such type of arrangement in the double effect system increases COP of the cycle as compared to the series flow cycle. The refrigerant distribution ratio (RDR) in the single effect refrigerant-parallel flow cycle and the solution distribution ratio (SDR) in the double effect solution-parallel flow cycle have been optimized. The optimization results, corresponding to the maximum COP, yield: RDR=0.30 and SDR=0.45. A comparative study between the single effect simple cycle, single effect cycle using heat recovery absorber, double effect parallel flow cycle and double effect series flow cycle has been presented. The analysis has been done by varying evaporator temperature (Te) from 5oC to 12.5oC and condenser/absorber temperature (Tc) from 30oC to 40oC.


FIELD: electricity. SUBSTANCE: application: in the field of electrical engineering. Device for symmetrical distribution of single-phase load between phases of three-phase network represents three-phase single- or multi-winding dividing transformer; at that each of secondary windings has additional turns independent from the main winding which are designed to compensate voltage drop in line and each consumer of the multi-winding dividing transformer is supplied from own or common (for single-winding dividing transformer) secondary winding, where line of each consumer is supplied from three in-series phase coils of the transformer, at that any two coils are connected in alignment while the third one is opposing connection. EFFECT: increasing capacity of distributing electric grids, reliability of power supply and safety of single-phase consumers.


Library is successful if it had been able to meet the needs and expectations of users. But until now Riau University Library Unit is still constrained by the quality of services provided such as: 1. The number of collections that are less meet the needs of visitors, as well as the lack of new books published in Library Unit. 2. The existing information systems today are still many problems. 3. System of preparation of the book is still not organized. 4. Less friendly and less of a response employees / officers in providing services. This study aims to determine the quality of service in improving visitor satisfaction in Riau University Library Unit and to investigate the factors that influence the quality of service in improving visitor satisfaction in Riau University Library Unit. Tjiptono theoretical concept in Hardiyansyah (2011: 40) There are six indicators to determine the quality of public services, namely: 1. Timeliness of care services 2. Accuracy 3. Courtesy and friendliness 4. Ease of getting care 5. Convenience in obtaining support services 6. Attribute servicing , This research method used descriptive qualitative method, ie the data obtained will be discussed thoroughly by the reality that occurs in institutions or where research is conducted. Then compared with the concepts and theories that support the discussion of the problems in this study, and then draw conclusions that are generally applicable. From the results of research and discussion conducted on "Quality of care in improving visitor satisfaction in Riau University Library Unit", it can be argued that the UPT service Riau University Library has been implemented but not maximum quality of services provided to library patrons. This is a drawback that can be used as a reference for the Riau University Library Unit in order to improve the quality of its services so as to improve the satisfaction of users of the library. Key words: Services, Visitor Satisfaction.


Editor, N ecrotizing scleritis occurs in Wegener0s granulomatosis (WG) and can also occur after ocular surgery (Bradbury & Taylor 2013). We present a 69-year-old female with scleral melting at the site of the lateral muscle insertion occurring 7 months after strabismus surgery in the left eye. Two years earlier, the patient presented with acute orbital inflammation in the left orbital apex, resulting in optic nerve compression, atrophy (Fig. 1D) and visual acuity of 'no light perception' (NLP) and exotropia (XT). Magnet resonance imaging disclosed orbital and sphenoidal sinus inflammation, and an orbital biopsy was performed at the department of neurosurgery, which showed no signs of malignancy (Fig. 1E). The patient was treated with systemic steroid, resulting in motility improvement. Left eye XT measured 45 prism dioptres by Krimsky method with fixation at 6 m.Due to the negative psychosocial effects of left exotropia, strabismus surgery was performed on the left eye by 9.0 mm hangback technique for the lateral rectus muscle with 6-0 polyglactin (Vicryl) sutures. Spersadex comp eye drops (Dexamethasonnatriumphosphate 1 mg/ml and chloramphenicol 5 mg/ml, Alcon laboratories, Ft. Worth, TX, USA) were instilled three times daily for 3 weeks, and Acular eye drops (ketorolac trometamol 5 mg/ml, Allergan Pharmaceuticals, Ireland) were instilled three times daily for 1 week postoperatively. Two months after surgery, the patient was orthotropic, and no scleral abnormalities were noted (Fig. 1A,B). Seven months later, she presented a painless 5 9 2 mm area of scleral melting at the original insertion of the left lateral rectus muscle (Fig. 1C) resulting in scleral perforation. The left eye was still NLP and was eviscerated. Microscopical examination showed scleral thinning (Fig. 1F) and inflammation with plasma cells, histiocytes and eosinophils, consistentwith chronic necrotizing scleritis of nodular type. With PAS,Grocott, Brown andHopps stains, no micro-organisms were detected. Giant cell arteritis was excluded by a negative temporal artery biopsy.


The Y2O3-Fe2O3-H2O-CO2 system, in which the source of CO2 and H2O was HCO2H and the Y2O3/Fe2O3 ratio was 3:5, was studied in order to det. the hydrothermal conditions necessary for the formation of oolites and the mechanism of their formation. At 200° the formation of oolites isostructural with natural ancylite occurred, along with a stable carbonate phase, Y(OH)CO3, and an FeCO3 siderite phase. Below 200° Fe(HCO2)2.2H2O and Y(HCO2)3 and I±-Fe2O3 were the stable phases. At 780° YFeO3 and magnetite were the stable phases. The formation of the oolitic structure is explained by assuming that at low temps. CO is evolved from the HCO2H to form bubbles which become the active centers for pptn. and crystn. [on SciFinder(R)]


Soft robots with inherent compliance have been recently investigated intensively for locomotion or manipulations. A critical problem for soft robots is the capability to estimate their shapes to enable closed-loop control for precise motion. In this paper, we propose a new low-cost sensor that can be leveraged for shape estimation of soft robots. This sensor, recently discovered as an artificial muscle, can be conveniently fabricated from low-cost conductive sewing threads. We recently found that the resistance will increase if the fabricated sensor is elongated due to an external force [1]. Since the sensor is inherently soft, it can be embedded into soft robots to estimate the shape. We establish a physics-based model to predict the external force and the displacement if the resistance is given and experimentally validate its correctness. Moreover, to demonstrate the sensing capability, we embed the proposed sensor into soft materials and successfully measure two curvatures of a two-segment soft robot. Therefore, the proposed sensor has the potential to estimate complicated shapes of soft robots to enable closed-loop control.


© 2020 V. N. Zayets et al.; Published by the Institute of Molecular Biology and Genetics, NAS of Ukraine on behalf of Biopolymers and Cell. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited Structure and Function of Biopolymers ISSN 0233-7657 Biopolymers and Cell. 2020. Vol. 36. N 5. P 329–340 doi: http://dx.doi.org/10.7124/bc.000A37


The author presents a philosophical interpretation of the contribution of bridge construction to the development of civilization.

Bridges have always been an important element of civilization, an instrument of human interaction with each other and with nature, an object of not only physical, but, above all, intellectual human activity. Therefore, their philosophical understanding, penetration into the logic and dialectics of the development of bridge construction is justified and necessary.

The following main factors determine the development of bridge construction: concept and criteria, requirements, competition, experience and information.

The concept of the projected bridge should take into account the categories of purpose, reliability, economy, traditions, the level of design achieved, personal preferences and experience of the designer.

The goal pursued by the construction of a specific bridge in a specific location is determined mainly by current needs, is formulated in the Terms of Reference and is regulated by the levels of consumer properties set in the norms.

At the same time, the criteria of strength and reliability must be observed throughout the entire life cycle. The level of reliability is provided by design standards.

The requirements for bridges should contain social, technical and humanitarian aspects. The economy is almost always, at least in our country, the main criterion when choosing a bridge option.

Competition is one of the main conditions for the development of nature and human society. There are three types of competition in the field of bridge construction: between different countries (competition of prestige), competition of scientific and design schools, competition in bidding.

Experience and information are important for the development of bridge construction. We are talking here about the collective experience of the bridge community.

An effective means of exchanging experience and ideas is technical literature, and above all, technical journals and collections, various bridge forums.


We would like to thank Dr. Gires for the letter concerning our article ([1][1]). We are very glad that Dr. Gires considers our data on how EGFR activation affects endometrial cancer cell invasiveness via EpCAM activity novel and interesting. The study highlights not only the function of EpCAM as a


Thank you for downloading people places and change an introduction to world cultures. As you may know, people have look numerous times for their chosen novels like this people places and change an introduction to world cultures, but end up in malicious downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they are facing with some harmful virus inside their computer.


The utility model discloses an analog signal excitation system for chip detection. The excitation system comprises an digital to analog converter DAC, a multipath input selection driver, a multipath linear amplifier, a multipath output driver, a resistor voltage dividing circuit and an analog-to-digital converter ADC, wherein the multipath input selection driver is connected with the DAC and the multipath linear amplifier, the multipath output driver is connected with the multipath linear amplifier, the first output end of the multipath output driver is connected with a detected chip, the second output end of the multipath output driver is connected with one end of the resistor voltage dividing circuit, and the other end of the resistor voltage dividing circuit is connected with the ADC. According to the utility model, detection signals of the chip to be detected are converted into analog signals, impedance conversion, signal amplification and current amplification are carried out on the analog signals, and finally obtained analog signals are sent to the chip to be detected; and thus, the measuring precision of the detection signals is improved to the maximum, the cost is reduced and the accuracy of the detection signals can be ensured.


It was observed that Zn~(2+) and Mn~(2+) additives played the activators and quenchers for the orange emission of colloidal ZnS∶Mn~(2+) nanoparticles, respectively. The time decay curves of Mn~(2+) 580 nm emission are nonexponential and become slower as Zn~(2+) is added, faster as Mn~(2+) added. On the basis of Langmuir isotherm model, the adsorption-desorption equilibrium constant K is obtained to be 2.9×10~4(mol/L)~(-1). The activation process resulted from the formation of monolayer ZnS outside of nanoparticles, which blocked the nonradiative pathways related to the dangling bonds of lone pairs on surface S~(2-). It is worth noting that the blue emission is also activated on introduction of Zn~(2+), indicating the original quenchers eliminated by the passivation of the surface through forming the ZnS shell can quench both the blue and the orange emission bands. It is not appropriate to describe the quenching process aroused by the addition of Mn~(2+) using the standard Stern-Volmer model. Considering Poisson statistics and assuming that one Mn~(2+) is sufficient for 100% quenching for orange emission, the reasonable linear plot is obtained. The average size of nanoparticles is 2.7 nm less than that calculated within the framework of effective mass approximation (EMA) model. The plausible reasons are as follows: 1. the increase of E_g owing to quantum confinement effect is overestimated by EMA; 2. the assumption that one Mn~(2+) is sufficient for 100% quenching of orange emission does not consist with the actual situation on the ZnS∶Mn~(2+) colloids. The quenching centers induced by the addition of Mn~(2+) may probably be Mn~(2+) themselves adsorbed on the surface of nanoparticles, which interact with the interior Mn~(2+) to perform Mn-Mn energy migration within short distance. Such opinion and the formation of the manolayer of ZnS on the surface is supported by the fact that the orange emission intensity is almost unchanged with the addition of Mn~(2+) after the activation process has taken place due to the addition of Zn~(2+). Surface or surface states play a crucial role on the optical properties of nanoparticles due to the relatively larger (surface)(-to-volume) ratio compared to the bulk. We expect the results may help to approach the nature of the mechanisms that surface or surface states dramatically affect the optical properties of nanoparticles.


Sustainable development is an outcome of more than economic processes. It is an outcome of economic, social, and political processes that interact with and reinforce each other in ways that hinder or facilitate its achievement. To reach sustainable development, opportunities need to be generated, good initiatives at all levels facilitated, and stability ensured. This requires actions at local, national, and international levels. How can priorities be decided in practice? What framework is needed to ensure economic growth and an effective distribution of wealth that generates equality of opportunities? This paper suggests that to accomplish sustainable development, it is not enough to review the way economic development has been researched and conducted. An integral approach to economic development is needed, i.e., an approach that seeks to strengthen the civil and social institutions required for it. This, in turn, necessitates an integrated view of the person in society and, consequently, a focus on the economic agent's decision process acknowledging him/her in a holistic manner and in his/her social dimension.


Dynamical phase transitions (DPTs) are generally defined under two different but known-to-be related categories: DPT-I where the equilibrium value (or long-time average) of the order parameter as a function of the control parameter demonstrates a phase boundary; DPT-II where the Loschmidt return rate shows a cusp singularity in real-time dynamics. In this Letter, we introduce a quantum phase transition far from equilibrium based on a parametric temporal cutoff whose form can be derived from the velocity bounds of the system. We find that far away from the equilibrium, two-time correlators at the cutoff could exhibit order parameterlike behavior in analogy to equilibrium quantum criticality, i.e. zero in the disordered phase and nonzero with a power-law scaling once the control parameter reaches a critical boundary. For the integrable Ising model, the dynamic phase boundary coincides with the transition point of the underlying equilibrium transition, although the system is initially prepared in a fully polarized state. Once the integrability is broken, dynamical order persists with phase boundary shifted from the equilibrium one. The scaling dimension of the observed power-law scaling differs from the Ising universality class and its value changes as one moves away from integrability. Our results point to true nonequilibrium criticality and we elucidate the origin of this novel dynamic transition by studying the hierarchy of timescales in the dynamical response.


In this paper, we investigate vulnerability of a so called "cellular" and that of a multi-spot diffusing (MSD) multi-input-multi-output (MIMO) architecture to shadowing and its effect on communications cell size and the required transmit power. Because signal path obstruction by furniture is easier to predict and avoid, we are mainly concerned with shadowing and blockage caused by people either sitting or standing. To avoid blockage of communication link by a user of portable units, maximum radiation angle at the transmitter in both configurations must not exceed 45/spl deg/. This restricts communication cell size. We show the probability of blockage of a cellular link depends almost linearly on the distance of the portable unit from the communication cell center. Unlike cellular links, MSD-MIMO links can be designed to be robust against blockage, though still vulnerable to shadowing. In a typical office having a height of 3 m, probability of shadowing is less than 2% and in majority of cases shadowing causes less than 50% reduction in the received signal power. Power penalty due to shadowing is insignificant (less than 0.1 dB) with a 1% outage.


This study is aimed at evaluating the phenptypic and genetic diversity of local cattle breeds in Cameroon. To this end, biometric data were collected randomly in six (6) localities of the Mayo-Banyo Division, on a sample of 321 adult Banyo Gudali zebu cattle (234 cows and 87 bulls) aged between 6 and 16 years and having a body condition score varying from 2 to 4. Results reveal a variability of the coat color i.e., 19,00% white coat and its derivatives (speckled, stoat, grey, truiture); 9.99% black coat and its derivatives (black list and black piebald); 18.06% piebald (4.67% black piebald and 13.39 red piebald); 52.94% red and its derivatives (red piebald and red list). The single-colored coats are less represented (38.94%)compared to double-colored coats (61.06%). The frequency of alleles S+, D, ED, Aa, E+, s, A+, e and P are respectively 0.315; 0.201; 0.140; 0.267; 0.859; 0.685; 0.733; 0.386 and 1.000. There is a predominance of white-black horns (50.2%) over grey horns (42.4%). This population is characterized by long hairs, straight-edged ears oriented laterally and with humps occupying a cervico-thoracic position. The facial and back profiles are straight. The neck has a horizontal curved profile, the rump with a low set tail. Crescent shaped horns predominate (73,5%) followed by the horns in low lyre (15,9%) with the other shapes (stump, lateral pointed tip, crown and asymmetrical deformed right or left) being the least represented. The raised horns (92.5%) are predominant. Erect and moderate humps (86.6%) are dominant over drooping ones (13.4%).


Intercellular adhesion of Jurkat lympho- cytic cells was investigated by use of monoclonal antibodies 33B6 and 18D3, which bind to the � integrin receptor. 33B6 induced homotypic aggre- gation of Jurkat cells, whereas 18D3 inhibited this aggregation. Jurkat cells could be induced to aggre- gate at low 33B6 concentrations corresponding to 5% �l mtel'1fl site occupancy, and the rate of aggre- gation was maximum at 30% occupancy. Simultane- ous addition of mAb 18D3 and 33B6 demonstrated that the two antibodies mediate changes in thei integrin activation state that are competitive in na- ture. Aggregation through f3i integrin induced by 33B6 was reversed by subsequent addition of 18D3. To further examine the mechanism by which 33B6 and 18D3 affect cell adhesion function, we explored the binding ofmonoclonal antibody (mAb) 15/7. This mAb recognizes an activation epitope of thebite- grin and has been shown to sustain cell adhesion to vascular cell adhesion molecule 1 (VCAM- 1 ) and fibronectin. Activation of Jurkat cells with Mn2' caused a 2.5-fold increase in 15/7 binding but did not increase binding of 33B6. 33B6 partially blocked 15/7 binding to �3i integrin on unstimulated and Mn2'-activated Jurkat cells. 18D3 did not affect itiAb 1 5/7 binding. These results indicate that 33B6 and 18D3 modulated homotypic aggregation by in- ducing a novel activation state of the very late acti- vation integrin distinct from the state recognized by 15/7, which supports cell binding to VCAM-1 and fibronectin. J. Leukoc. Biol. 59: 872-882; 1996.


This paper investigates finite-time attitude tracking control strategies for hypersonic flight vehicles (HFVs) with parameter uncertainties, external disturbances, and actuator saturations by applying sliding model control, adaptive mechanism, and nonlinear disturbance observer techniques. A nonlinear dynamic model of HFV attitude system in reentry flight phase is established. Then, a basic attitude control method of the HFV system is designed based on a terminal sliding mode control (TSMC) scheme to accommodate the system-lumped disturbance torques and guarantee the finite-time stability. To relax the prior knowledge of bounded lumped disturbance of the TSMC-based HFV attitude system, an adaptive TSMC (ATSMC) scheme is proposed. In order to relax the limit of compound uncertainties and attenuate chattering phenomenon of the TSMC-based HFV attitude system, a nonlinear disturbance observer-based TSMC (DO-TSMC) scheme is presented, which enhances the disturbance attenuation and robust tracking performance. Finally, simulation results of a generic X-33 nonlinear model exhibit the effectiveness of the proposed TSMC, ATSMC, and DO-TSMC schemes.


The objective of the Capacity Building of the Pakistan Bureau of Statistics Project is to help the Pakistan Bureau of Statistics with: the re-basing of the Consumer Price Index (CPI); improving sampling for the HIES, Population and Agricultural Censuses; the implementation of the Household Income and Expenditure Survey, or HIES-Pakistan Social and Living Standards Measurement Survey, or PSLM; and the implementation of Computer-assisted personal interview, or CAPI to collect price data. The level two restructuring aims to: (1) extend the closing date 1 year from December 2016 to December 2017; (2) adjust the target dates of the project indicators to match the new end-date of the grant; (3) add travel for STCs as an eligible expense category; and (4) slightly modify some project activities to align with the current demands from the government and the extended time frame.


This study was aimed to examine energy, density, proximate, dietary fiber and
macronutrients ratio on the glycemic index and glycemic load of 6 kinds Indonesian local
package menus made of red rice as a staple food and several other potentially antidiabetic
food ingredients. The design was a quasi-experimental with 20 participants each of which
were10 non-diabetic subjects (4 males and 6 females) aged between 20.3±1.0 years old
and 10 subjects with type 2 diabetes (5 males and 5 females) aged between 54.4±9.3 years
old. The results showed test package menu 1 (nasi liwet) has glycemic index and glycemic
load can be accepted as healthy menu package in both, non-diabetic subjects (glycemic
index = 23.8±9.2; glycemic load = 11.9±4.6) and diabetes subjects (glycemic index =
17.5±8.5; glycemic load = 8.7±3.3). There is a moderate to a strong negative correlation
between glycemic index and the incremental area under the curve with the content of
protein, fat, total dietary fiber, soluble dietary fiber, and moderate to strong positive
correlation with macronutrients ratio. In conclusion, prevention of increased postprandial
blood glucose in the management of type 2 diabetes mellitus diet can be done by
preparing a local Indonesian menu package based on red rice food ingredients by
considering the type of menu, protein, fat, total and soluble dietary fiber, and
macronutrient ratio.


The paper is devoted to experimental determination of regularities of cyclic paths of complete and incomplete permutations, realized by means of the simplest regular OCCM. The paper is based on results obtained before and it specifies them.


Due to the exponential growth of biomedical repositories such as PubMed and Medline, an accurate predictive model is essential for knowledge discovery in Hadoop environment. Traditional decision tree models such as multivariate Bernoulli model, random forest and multinominal naive Bayesian tree use attribute selection measures to decide best split at each node of the decision tree. Also, the efficiency of document analysis in Hadoop framework is limited mainly due to the class imbalance problem and large candidate sets. In this paper, we proposed a two phase map-reduce framework with text preprocessor and classification model. In the first phase, mapper based preprocessing method was designed to eliminate irrelevant features, missing values and outliers from the biomedical data. In the second phase, a map-reduce based multi-class ensemble decision tree model was designed and implemented on the preprocessed mapper data to improve the true positive rate and computational time. The experimental results on the complex biomedical datasets show that the performance of our proposed Hadoop based multi-class ensemble model significantly outperforms state-of-the-art baselines.


The marketable surplus is the produce left over after meeting the household requirement. The average family size of above 5 members except medium holdings and average holding of 3.64 ha. The proportion of cultivated land was 92.58 per cent of total land holding. The production of cereals increased with farm size and the marketed surplus was more than marketable surplus for marginal and small holdings indicating distress sale more for marginal farms. The marketed surplus of pulses was more than marketable surplus, may due to sale of farm produce and purchase of dal.


Mica was modified with a tetradecyl group, and the products were characterized in various respects. 1,3,5,7-Tetramethylcyclotetrasiloxane (TMCTS) was deposited on mica at 80•Ž by chemical vapor deposition and was polymerized catalytically to form a poly(methylsiloxane) layer on the surface. Mica coated with TMCTS was prepared in four varieties with different mean particle sizes. The coated amount of TMCTS and the amount of Si-H groups decreased with increasing mean particle size. Mica modified with a tetradecyl group was synthesized from silicone coated mica by hydrosilylation with 1-tetradecene. The added amount of tetradecyl groups decreased with increasing mean particle size. The water contact angles and the yield value and the viscosity of disperse systems of mica modified with the tetradecyl group were dependent on the added amount of tetradecyl groups. Key-words : Chemical vapor deposition, Hydrosilylation, 1,3,5,7 Tetramethylcyclotetrasiloxane, Tetradecyl group, Viscosity


Canada's indigenous population (which includes the First Nations, Inuit, and Metis) suffers from startling health inequities that have been largely attributed to the persisting effects of colonization leading to poverty, overcrowding, and unemployment (Macaulay, 2009). As important social determinants of health, these conditions have played a critical role in the progression of both communicable and non-communicable disease epidemics amongst the indigenous population, including tuberculosis (TB) and human immunodeficiency virus (HIV). The prevalence of TB and HIV within the indigenous population is approximately 34 times and 2 times greater than in the non-indigenous population, respectively (PHAC, 2012; PHAC, 2016). The government of Canada has responded to these striking discrepancies by implementing national HIV and TB prevention and control programs which include initiatives targeted toward the indigenous population (PHAC, 2004; PHAC, 2014). However, these programs fail to adequately address the strong association between HIV and TB, and the importance of this association in the treatment and prevention of disease. The need to address this association is further magnified within indigenous populations which suffer from both these infections at aberrantly high rates.


A fairy tale is a piece of folk work (or literary/ author's fairy tale) with the elements of fantasy, which has its own peculiarities of reading. The formation of the primary school pupils' expressive reading skills at the lessons of literary reading is a complex process. Contemporary methodologists have introduced a system of methodological techniques of learning a fairy tale, taking into account its genre peculiarities. In the process of work at a fairy tale the «Grandmother-narrator» /picture № 2/ technique is being realized: at the lesson the text of a fairy tale is being expressively read by a teacher, some fragments are being read by the pupils, preserving the peculiarities of folk performing manner. The peculiarities of a fairy tale structure: the presence of the beginning, main part, ending, triple repetitions is caused by the usage of the technique («I, II, III bricks») in picture № 3). Permanent epithets, emotional and evaluative words create the unique atmosphere of magic in fairy tales. While listening to or reading the fairy tales pupils figure out and use these lexical units in order to characterize fairy heroes, this way realizing the technique in picture № 6. Working at characteristics of positive and negative heroes an important role is given to: «pupils' questions to the text» (What? Who? Where?); «tricky questions» – a technique in picture № 4). In order to express their attitude to the fairy characters the pupils select «tooltips» (picture № 8). A fairy tale has a didactic nature. The characters are punished for being evil and rewarded for the kindness in it. In some fairy tales the moral is formulated, in others the moral of the tale is not formulated. In such case the technique «Make a note of that» /picture № 7/: it is suggested to the pupils either to formulate the tale's idea by themselves, or to choose the second corresponding name of the fairy tale from the list of some proverbs. There are some elements of fantasy in the structure of a fairy tale. One of the techniques in the process of work at a fairy tale is the pupils' looking for the elements of fantasy, a teacher's talk about the fact that the main spell is a human being's kind heart will also be appropriate here. Working with a book exhibition will help the pupils to differentiate a folk and a literary tale, to understand in what respect they differ, what groups they are divided into /the technique in picture № 1/. In the process of work at the fairy tale an efficient technique will be a lesson of creativity «Making up a fairy tale independently». Such lesson will help the pupils to notice the peculiarities of a fairy tale plotting best.


The Kabbalah Centre is a new religious movement that seeks to disseminate the teachings of kabbalah to a universal audience. Kabbalah Centre teachings are an elaboration and interpretation of the kabbalistic writings of Yehuda Ashlag (18851954). Kabbalah Centre teachings are based on the creation myth common to kabbalistic theosophical speculation. One of the foundational stories for the Kabbalah Centre teachings on sexual ethics is the biblical story of the Garden of Eden. The reflexive relationship of the lower and upper worlds means that restraint, giving, and receiving are simultaneously physical and spiritual events within the earthly and metaphysical realms. The Kabbalah Centre presents a fairly conservative view of gender roles in general and within marital relationships in particular. The Kabbalah Centre movement presents its teachings as the cure for ailing interpersonal relationships, dysfunctional sexual behavior, and unexciting and emotionally dead marriages. Keywords: Kabbalah Centre teachings; kabbalistic writings; marital relationships; sexual ethics


A newborn boy had a dusky − red mass on his left anterior neck region and left face. The mass was hard and about 8 cm in diameter. His blood examination revealed thrombocytopenia, coagulopathy and anemia, and his chest X − ray showed cardiomegaly. The thrombocytopenia and coagulopathy with large hemangioma was diag-nosed as Kasabach − Merritt phenomenon. Pharmacological and radiological treatment failed to improve his condi-tion, and the high − output cardiac failure deteriorated to a need of continuous hemodiafiltration due to acute renal failure. Transarterial embolization with glue was performed for the congenital hemangioma on the 5th day of life. His cardiac failure as well as Kasabach − Merritt phenomenon dramatically improved after the procedure. Most hemangiomas in children regress spontaneously. However, some of them associate life − threatening high − output cardiac failure and consumptive coagulopathy. Transarterial embolization is required for a large hemangioma with such a condition.


The necessary Information concerning the origiii and contents of the Ummul-kitäb has already been given in my article, — "Notes sur rUmmu'l-kitäb" (hereafter briefly referred to äs the "Notes"), published in the Revue des ßtudes Islamiques (1932, pp. 419—482). As the space here available is limited, it seems advisable to take for granted that every reader of the original text of the Umnwfl'kitab, which is offered here, will make himself familiär with the "Notes", and thns obviate the necessity of repeating here all that is said in that paper. In these preliminary rernarks only such matters are touched upon äs require amplification or modification.


In the summer of 2010 Iwas invited to take part in an art show whose central theme was Skin. In preparation, I researched how artificial skin was made and used to create special effects in Hollywood. Artificial skin is made from a latex that is sold in buckets and looks much like house paint. For this group exhibit on Skin, I used the latex by pouring small amounts onto my studio floor and after this dried I could peel the strips of latex from the ground and use them to make miniature skin clothing. Theminiature skin clothing was used in the 2010 exhibit, but I was left with a third of a bucket of latex.


The role of adrenaline in the body, especially in athletes, is considered. Special attention is paid to the cardiovascular system performance in conditions of the continuous release of adrenaline. The ECG shape and the possible therapy in case of adrenaline heart are discussed.


USING PROJECTION TO ACCELERATE RAY TRACING An ast asia Bezerianos M.Sc. Graduate Department of Cornputer Science University of Toronto 2001 The high cost of Ray Tracing image rendering has driven many researchers to devise acceleration techniques like bounding volume hierarchies. This thesis introduces new ways of building bounding volume hierarchies. We modify existing algorithms to use bounding volumes projected ont0 the viewing and light planes. This allows faster traversal of less tight hierarchies. First, hierarchical structures are constnicted using only the information derived fiom the projection of the bounding volumes. Second, a view independent hierarchical structure is projected ont0 the viewing and light planes. Finally, we augment each of the previous hierarchies with testing rayç against both the projected and the view independent volume. Thus fast traversal of the hierarchy and tight modeling are combined. Testing demonstrates that projection hierarchies accelerate Ray Tracing when the number of objects in a scene is large and the number of possible hierarchies to choose hom is limited.


Spalding approaches Oglethorpe's career by asking " whedier die man was really wordiy of die admiration accorded to him." Was he one of die " effective and successful colonial founders such as Winthrop, Smith, Raleigh . . . and Penn "? Such qualified filio-pietism does not, however, preface a detailed account or full assessment. Spalding produces instead nine short, topical chapters and an epilogue, on the grounds that this makes it easier for him to " reach judgments at appropriate places." Some readers may doubt die usefulness of such an approach; odiers may feel tiiat Spalding, a careful, able, and sensible scholar, should have been more ambitious, attempting a fuller biography. As it is, he never directly lays out either die chronology or the developing context of Oglethorpe's American years nor does he remember that all his readers will not be as immersed and as knowing (Spalding is presumably a Georgian, certainly edits die Georgia Historical Quarterly, and teaches at die University of Georgia) about early Georgia as he is. What is probably most obscured by his topical analysis is the contextual (and chronology is part of context) explication of die constrictions on Oglediorpe which did not result from his personality but from market forces, human cupidity and jealousies, or odier factors. These reservations aside, Spalding has produced an attractive, scholarly, and sensitively-written book, illuminating the critical aspects of Oglediorpe's Georgia years. Spalding suggests diat the Trustees and Oglethorpe failed to provide conditions favourable to white migrants and white labourers, especially generous land grants, flexibility in land transfers and die encouragement of realistic cash crops rather than silk and vines. This defeated their hope to make Georgia a colony of yeoman-farmers: slavery could not be restricted to die colonies north of Georgia or prevented from spreading soudi-westward widi striking results for American history. But Oglediorpe was a highly successful Indian diplomat and his rallying of resistance to the Spanish invasion of Georgia in 1742 was important. Spanish success might have resulted in Soudi Carolina's invasion, in the adhesion of the slaves there to die invaders, and perhaps in a great slave uprising extending (this at least was Oglethorpe's belief) to Maryland. Oglethorpe and die other philandiropic humanitarians of die eighteendi century are interesting figures, especially when studied in relation bodi to the materialism and to die pietism of dieir time. If, as die audior tells us, many new primary and secondary sources have appeared since the last major biography of Oglethorpe in 1936, perhaps diere is scope for a larger study.


The principle,the scheme and the implement of the frame synchronous scheme with FPGA technology are introduced, and the problems needed to notice in the design. Several modules are presented with VHDL.


Abstract The temperature dependence of the piezoelectric constants of single crystals of ammonium sulfate (NH4)2SO4 was measured by means of a quasi-static method at about 400 Hz above the liquid nitrogen temperature. The piezoelectric activity appeared below the Curie point Tc . The components of d 11 and d 12 were ordinary and slightly depended on temperature except near the transition point. Their values at 200 K were −4.6 and 6.8 pC/N, respectively. On the other hand, the d 13-component could not have been detected around 85 K, however it gradually appeared in the heating run to negative maximum −0.7 pC/N around 200 K. Moreover it changed its sign at 217 K, reached a positive maximum 1.6 pC/N and vanished at Tc .


This paper extends the conditional logit approach (Rasch, Andersen, Chamberlain) used in panel data models of binary variables with correlated fixed effects and strictly exogenous regressors. In a two-period two-state model, necessary and sufficient conditions on the joint distribution function of the individual-and-period specific shocks are given such that the sum of individual binary variables across time is a sufficient statistic for the individual effect. By extending a result of Chamberlain, it is shown that root-n consistent regular estimators can be constructed in panel binary models if and only if the property of sufficiency holds. In applied work, the estimation method amounts to quasi-differencing the binary variables as if they were continuous variables and transforming a panel data model into a cross-section model. Semiparametric approaches can then be readily applied. Copyright The Econometric Society 2004.


A new numerical model for stratified two-phase flows with wavy interface is derived in this study. Assuming an equilibrium condition between turbulent kinetic energy, potential energy and surface energy, the turbulent length scale in the inner region of a two-layer turbulence approach can be described by a statistical model to account for the influence of the waves. The average wave number, which is an input parameter to this model, is taken from wave spectra. They can be predicted from a Boltzmann statistic of turbulent kinetic energy. The new turbulence model is compared with the two-phase k-ε-turbulence model. Time averaged flow properties calculated by the new approach, such as velocity, turbulence and void profiles, are shown to be in good agreement with experimental data.


A power loss vector diagram is proposed and used as a tool to investigate real and imaginary currents to trace power flow. The results of investigation show that in some cases the loss allocating results, the by-product of power flow tracing results, obtained by this current tracing method are obviously unreasonable. Simulations verified this discovery. It is therefore necessary to find a reasonable loss allocation rule when tracing power flows.


As the High Education in China has evolved into a new phase of Popularization Education, almost all the institutes of high education have been involved in fierce competition and self-decision. Therefore, it has become an essential issue for the survival and development of an institute of high education to fully strengthen its Core Competence. Institutes of high education should focus on strengthening the Core Competence by means of improving faculty qualification, promoting first-class subjects, ensuring quality control and enhancing administrative efficiency.


In high voltage testing there is a need to measure both the peak value and rms value of power frequency voltage. This paper describes method to calculate accurately both quantities; even when the frequency is not stable. The method can handle waveforms with harmonic content, and an uncertainty of few ppm can be achieved. Method is not sensitive to frequency fluctuation and phase lock loop is not needed.


A compact form can be used to describe an arbitrary high order sigma delta modulator. This provides insight into the structure of limit cycles in sigma delta modulators. We consider modulators of any order with periodic output. We make no assumptions regarding the input and are thus able to prove necessary conditions for limit cycles in the output. We show that the input must be periodic, but may have a different period from both integrator output and quantised output. We derive what this implies regarding limit cycles for sinusoidal inputs. Finally, we give examples where sinusoidal input to a third order modulator results in a limit cycle of a different frequency.


SILVA, Anderson Goncalves. Imagination and its uses: about symbolization in Schelling. 2009. 000 f. Thesis (Doctoral). Faculdade de Filosofia, Letras e Ciencias Humanas. Departamento de Filosofia, Universidade de Sao Paulo, 2009. Abstract: This work is structurated, so to speak, in three parts. The fisrt part aims This work is structurated, so to speak, in three parts. The fisrt part aims at "constructing" the notion of language in relation to mythology. In the second part, the relation between mythology and politic strategy. In other words, the "use" of mythology that could be called "technical use of mythology". In the third part, language, mythology and politics articulated in symbolization in Schelling's Clara. Key-words: Schelling – language – imagination – history – mythology – symbol – Clara


The fast polynomial transform (FPT) for computing 2-D cyclic convolutions is modularized into identical modules. In the new method, the 1-D cyclic polynomial convolution is decomposed into cycle convolutions of polynomials, all of the same length. Thus, only FPTs and FFT's of the same length are required. As a consequence, the architecture is more regular and naturally suitable for a VLSI implementation. >


Traffic flow transmission is a constantly important aspect of complex networks, geographical information science, and other science and engineering fields. Previous studies have shown that vehicle flow is more strongly correlated with morphological properties of streets than those of axial lines. In addition, street-based topological representations are more suitable for vehicle flow prediction, as well as more memory-oriented and global in nature. In this study, we construct a dual graph to represent the street–street relationship and propose a routing strategy for networks on the basis of gravitational field theory. We aim to diminish traffic congestion and enhance the transmission performance of networks. We borrow from gravitational field theory in establishing a gravitational field stimulated by a node in packet transmission and in defining the corresponding gravitational field equation. On the basis of this study, we present a mathematical model and a routing strategy. Experimental results indicate that compared with the shortest path routing strategy, the proposed method considerably enhances network capacity and effectively balances network traffic flow, especially for congested networks. We achieve critical gravitation that can always maximize network capacity, regardless of the values of other parameters.


This paper investigates the problem of wideband multiple-input multiple-output radar transmit beampattern synthesis in a spectrally dense environment, and two optimization problems are formulated according to practical consideration. The first one is beampattern matching design under the scenario of known interference spectral band while the second addresses minimum peak sidelobe beampattern design given both interference spectral band and interference direction. In addition, to improve transmission efficiency, other than the peak-to-average power ratio constraint, a useful modulus constraint, namely, dynamic range ratio, is adopted in our development. The resultant problems are nonconvex and nonsmooth, together with multiple constraints. The advantages of the majorization-minimization and alternating direction method of multipliers (ADMM) are combined to handle them. We first use the majorization technique to handle the nonconvex and nonsmooth issues and then utilize the ADMM to solve the multi-constrained problem. Two variants of the ADMM, called majorization-ADMM and proximal-ADMM, are devised, and their convergence is also studied. Finally, numerical examples are provided to verify the effectiveness of the proposed algorithms.


In the age of information,the university students ought to be capable of the ability of studying independently,the innovation ability,the stronger adaptive capacity and the reflectively criticizing ability.But in the current appraising mode of university students,there are shortcomings as the on-track appraising means,the partial appraising contents,making the appraising result utility,attaching importance to universal but lighting personality and so on.These have hindered the development of ability to obtain knowledge independently,the cultivation of the student initiative spirit and innovation ability,and the development of students' individual character.Directing against the shortcomings,researchers have raised a certain number appraising mode of university students to improve current appraising mode of university students.During construction of new appraising mode for university students,we should follow the principle of the opening,flexibility and democracy.We use the flexibility principle to inspect students' development from many-faceted and multiple means,and attend to the individual diversity of students,not to use cognition as only appraisal goal.We should conceive the containing aptitude to exercise the student learning and behavior to respect students' individual differences of the appraisal.These principles establish the main body status and improve the full-scale development of university students by the scientific appraisal.


In spite of prior extensive research on the role of information systems (IS) in controlling interorganizational transactions, very little has been sabout the role of handheld computers in inter-organizational control. The literature on han dheld computers suggests that their facilities of mobility and connectivity engender usability patter ns that are significantly different from those related to static and bulkier computers. Yet, the Ilacks elaborate models explaining the role of handheld computers in inter-organizational contr ol. This paper draws upon the philosophical assumptions of transactions costs theory to analyze this role. Four scenarios resulting from this analysis are appropriation and institutionalization of technology, and interaction and comprehension between the organizations. It further synthesizes these scenarios to propose four socio-technical systems of control that make electr onic data transactions with handheld computers efficient. It argues that handheld computers suppla nt bureaucratic control, and engender more diverse and resilient systems of inter-organization al control. These roles will require IS researchers to rethink the sufficiency of tradition al mechanisms of control suitable for efficient inter-organizational transactions, and induce the n ext wave of research on the control of electronic data transactions with inter-organizatio nal IS.


The state-of-the-art routing protocols for Wireless Sensor Networks (WSNs) require statistical information about the wireless links to the neighbors in order to estimate their quality and select the best route to convey the data. This information is obtained through probing the neighborhood with beacons and/or the application traffic, thus becoming overhead expensive in terms of energy and bandwidth or dependent on the presence of application traffic (in the case of low power Medium Access Control - MAC layers). This work proposes the idea of obtaining the link quality information from a resource commonly present in WSNs but so far unexplored: the packet repetitions used for transmission (TX) in sender initiated preamble sampling MAC protocols. It explains an approach for modifying ContikiMAC (the default MAC protocol in Contiki's Rime stack) to extract useful link quality information from a single packet. The study performs an estimation of the cost of the proposal in terms of energy and reliability. The results support the claim that the method can yield an overall reduction in energy and bandwidth if the routing layer uses the provided link quality information.


The purpose of this study is to provide an overview to the company in order to plan sales and profit in accordance with what is desired. In doing sales planning and profit in advance to determine the break-even point, then the application of break even point analysis can be used to plan sales and profit planning. This reseаrch wаs conducted using descriptive reseаrch.The results of the аnаlysis conducted in PT Industri Mаrmer Indonesiа Tulungаgung (IMIT) in 2016 cаn be seen sepаrаtion cаn be known semi vаriаbel Rp 2.103.392.041 fixed costs аnd vаrаble costs Rp 1.826.159.887 with а contribution mаrgin rаtio of 56,40% while the BEP Multiproduk knowаble thаt PT Industri Mаrmer Indonesiа Tulungаgung (IMIT) reаch breаk even point аt the time of sаle of the compаny is Rp 3.729.594.815 or аt the time of sаle 58.334 m 2 . Cаlculаtion of 10,94% MoS. If the compаny wаnts profit rose 25%, the sаles to be аchieved is Rp 4.207.887.893 or 60.721 m 2 for product slаb mаrmer аnd 5.094 m 2 for product slаb kаsаr.Bаsed on the аnаlysis, the аnаlysis of breаk even point cаn be one of thetools thаt cаn be considered by the compаny for use in sаles аnd profit plаnning policy. Keyword : Break Even Point mix , Cost, Sales and Profil ABSTRAK Tujuan dari penelitian ini adalah untuk memberikan gambaran kepada perusahaan agar dapat merencanakan penjualan dan laba sesuai dengan apa yang diinginkan. Dаlаm melаkukаn perencаnааn penjuаlаn dаn lаbа terlebih dаhulu untuk menetukаn titik impаs, mаkа penerаpаn аnаlisis breаk even point dаpаt digunаkаn untuk merencаnаkаn perencаnааn penjuаlаn dаn lаbа. Penelitiаn ini dilаkukаn dnegаn menggunаkаn penelitiаn deskriptif.Hаsil аnаlisis yаng telаh dilаkukаn di PT Industri Mаrmer Indonesiа Tulungаgung (IMIT) pаdа tаhun 2016 dаpаt diketаhui pemisаhаn biаyа semi vаriаbel  dаpаt diketаhui biаyа tetаp sebesаr Rp 2.103.392.041 dаn biаyа vаriаbel sebesаr Rp 1.826.159.887 dengаn rаsio mаrjin kontribusi sebesаr 56,40%, sedаngаkаn BEP Multiproduk diketаhui bаhwа PT Industri Mаrmer Indonesiа Tulungаgung (IMIT) mencаpаi breаk even point pаdа sааt penjuаlаn sebesаr Rp 3.729.594.815 аtаu pаdа sааt penjuаlаn mencаpаi 58.334 m 2 . Perhitungаn MoS sebesаr 10,94%. Jikа perusаhааn menginginkаn kenаikаn lаbа sebesаr 25% mаkа penjuаlаn yаng hаrus dicаpаi sebesаr Rp 4.207.887.893 аtаu 60.721 m 2 untuk slаb mаrmer sedаngkаn untuk slаb kаsаr sebesаr 5.0934. Berdаsаrkаn hаsil аnаlisis yаng telаh dilаkukаn peneliti, аnаlisis breаk even point dаpаt menjаdi sаlаh sаtu аlаt yаng dаpаt dipertimbаngkаn oleh perusаhааn untuk digunаkаn dаlаm perencаnааn penjuаlаn dаn lаbа. Kata Kunci : Break Even Point Multiproduk, Biaya , Penjualan dan Labа


In the base of extracting vascular centerline using skeletonization algorithm,the tracking method of coronary vessel diameter measurement based on Measure of Match(MoM) evaluation model was proposed.The algorithm took account of the symmetry between the two edge lines of blood vessels and the centerline,and the optimized evaluation idea.By the quantitative measurement of the actual image and comparison with the actual diameter,it was found that using the proposed method can accurately measure blood diameter,and can effectively address the overlap of vascular branching and diameter measurement problems.


Retrospective look at ten years of assessing introductory statistics courses over quarters. Introduces a "how sure are you of this answer" question. Since Fall Quarter 1999, the authors have collected data from a required common final in introductory statistics and some finals in introductory psychology courses. After ten years we wonder whether there is some relationship between correct response and an individual student's assessment of their ability to answer a particular question correctly. Our study considers continuity in exams and the usefulness of asking students to assess their own problem solving ability. For each of twenty questions on a common final in an introductory statistics course, students are asked to rate their personal ability to answer that particular question correctly. Responses are studied on a number of scales. One set of scales is designed to study particular topics in introductory classes. The second set of scales looks at the difficulty of the problems in terms of literacy, skill and reasoning required to answer. In an age requiring 'customer satisfaction' we ask whether students are able to correctly utilize basic course skills and assess personal learning.


Accurate and complete cancer incidence data on Alaska Natives are available since 1969 as a result of collaborative efforts of the Indian Health Service and the National Cancer Institute (NCI). Cancer incidence rates from the initial 5 years of the Alaska Native Tumor Registry are compared with the most recent 5‐year period available. Cases are identified and information is collected on each patient in accordance with the procedures of the NCI Surveillance Epidemiology and End Results Program. Over the 25‐year period (1969‐1993), the numbers of newly diagnosed Alaska Native cancer patients each year have more than doubled. Age‐adjusted incidence rates have increased 28% in men and 25% in women. Cancer patterns in Alaska Natives continue to differ from those of U.S. whites and from American Indians living in the contiguous 48 States. Increases in Alaska native rates over time are due largely to increases in tobacco‐related cancers. Cancer 1998;83:1815‐1817. © 1998 American Cancer Society.


The urban development law is traditionally perceveid as the city expansion law. Yet, the town planning low does not grant the notion of the "opening to urbanization", the place it deserves. There is no definition of it, its judicial regime shall be deduced from a complex combinaison of various articles of the code. The "opening to urbanization" can be defined as the statutory transformation of a local town planning document which has the effect of classifying a wild environment into a built-up area or intro an area suitable for development. This tranformation can be made thanks to a modification or a review of the local urban development plan. The hypothesis of the creation of an united planning area, has been repealed by the solidarity and renewal urban act of december 13th 2000. The notion had an obvious signification in the soil managment, but the previous legislation granted it little attention. The "opening to urbanization" was just the occasion to organise a double procedure for the consultation of the people. The notion had a range of application limited to the future urbanization zones of the soil occupation plan, whereas in practise it had a larger scope. In december 2000 the lawmaker decided to expand the range of application of the notion, to natural and urbanisable future zones. The function of that notion has also been reinforced by the Solidarity and Renewal urban act of december 2000. On that occasion, the lawmaker has assigned to the notion of the "opening urbanization", new objectives which forestshadow a renewal about the urban development law. More than ever that law seems to be a receptacle for the various sectorial politics the purpose of which is the urban space.


The structural remodeling of extracellular matrix proteins in peripheral lung region is an important feature in chronic obstructive pulmonary disease (COPD). Multiphoton microscopy is capable of inducing specific second harmonic generation (SHG) signal from non-centrosymmetric structural proteins such as fibrillar collagens. In this study, SHG microscopy was used to examine structural remodeling of the fibrillar collagens in human lungs undergoing emphysematous destruction (n=2). The SHG signals originating from these diseased lung thin sections from base to apex (n=16) were captured simultaneously in both forward and backward directions. We found that the SHG images detected in the forward direction showed well-developed and well-structured thick collagen fibers while the SHG images detected in the backward direction showed striking different morphological features which included the diffused pattern of forward detected structures plus other forms of collagen structures. Comparison of these images with the wellestablished immunohistochemical staining indicated that the structures detected in the forward direction are primarily the thick collagen type I fibers and the structures identified in the backward direction are diffusive structures of forward detected collagen type I plus collagen type III. In conclusion, we here demonstrate the feasibility of SHG microscopy in differentiating fibrillar collagen subtypes and understanding their remodeling in diseased lung tissues.


Walter Block's critique of my paper fails to address the main argument: that Ludwig von Mises's support for laissez faire comes from a comparison of the systems recommended by the ideologies of socialism, interventionism, and liberalism. Mises compares these systems according to the criterion of their capacity to achieve the goal of satisfying material wants. This goal is either explicit or implicit in the arguments made by those who subscribe to the above ideologies. He uses value-free economic reasoning to determine whether the systems recommended by the three ideologies will achieve the goal. In this reply, I reaffirm the argument in the face of Block's critique. In addition, I address two other arguments. The first is the implicit argument in Murray Rothbard and in Block that Mises erred because he failed to take account of all the goals that policy advocates might have in recommending a policy. I argue that he did not err. The second is that Mises is a utilitarian, an argument also advanced by Leland Yeager. I argue not only that Mises was not but also that he repudiated the idea that his support for laissez faire was based on utilitarian welfare principles. The reply also answers some of Block's more specific criticisms of my paper. Copyright 2005 American Journal of Economics and Sociology, Inc..


A field investigation entitled "Effect of GA3 on growth, yield and quality of different rose varieties" was carried out during Kharif season of the year 2016-2017 at Horticulture Section, College of Agriculture, Nagpur with the objectives to study the different rose varieties for growth, flower yield and quality parameters and to find out the suitable scented rose variety for commercial cultivation in Nagpur conditions. The experiment was laid out in Factorial Randomized Block Design with four treatments. The treatments were replicated thrice. The treatments are G1-control G2100ppm G3200ppm G4300ppm with varieties V1 Toro, V2 Double delight, V3 -Gladiator. The result of the present investigation indicated that, significantly maximum vegetative growth in respect of height of plant, branches plant -1 leaf area and internodal distance were recorded by variety Gladiator and maximum plant spread were recorded in variety Toro and GA3 200ppm. Similarly yield parameters, maximum yield plot -1 , yield ha -1 were recorded by variety Gladiator and GA3 200ppm.Thus, it can be inferred from the present investigation that, the variety Gladiator and GA3 200ppm was found to be better in respect of vegetative growth and yield and parameters for commercial cultivation under Nagpur conditions.


This piece analyses the CJEU's Bablok Case from the perspective of Law and Economics. It uses doctrinal and economic argumentation to test its effects on international trade as well as on the legal order of the EU. It tests whether these insights lives up to the expectations of the lawmaker. Furthermore, it makes policy recommendations how these insights can be used to further policy making in this area at EU level.


ABSTRACT This article examines the puzzling phenomenon that many Chinese liberal intellectuals fervently idolize Donald Trump and embrace the alt-right ideologies he epitomizes. Rejecting 'pure tactic' and 'neoliberal affinity' explanations, it argues that the Trumpian metamorphosis of Chinese liberal intellectuals is precipitated by their 'beacon complex', which has 'political' and 'civilizational' components. Political beaconism grows from the traumatizing lived experience of Maoist totalitarianism, sanitizes the West and particularly the United States as politically near-perfect, and gives rise to both a neoliberal affinity and a latent hostility toward baizuo. Civilizational beaconism, sharing with its nationalistic counterpart—civilizational vindicativism—the heritages of scientific racism and social Darwinism imported in late-Qing, renders the Chinese liberal intelligentsia receptive to anti-immigrant and Islamophobic paranoia, exacerbates its anti-baizuo sentiments, and catalyzes its Trumpian convergence with Chinese non-liberals.


.............................................................................................................................7 INTRODUCTION ....................................................................................................................9 METHODS ............................................................................................................................ 14 Sampling sites .................................................................................................................... 14 Sample collection and processing .................................................................................... 15 Environmental data ........................................................................................................... 16 Deriving the phytoplankton-based metric: PDI ............................................................... 16 Assessing the performance of the model ......................................................................... 17 Testing the assumptions of the model .............................................................................. 18 RESULTS .............................................................................................................................. 21 Performance of the model ................................................................................................. 21 Correspondence to the original training set ..................................................................... 22 TP as a driver of the community composition................................................................. 23 DISCUSSION ........................................................................................................................ 25 Rationale for the use of PDI ............................................................................................. 25 TP and other environmental variables structuring the planktonic community.............. 27 Effect of climate change ................................................................................................... 30 4 Summary ............................................................................................................................ 32 ACKNOWLEDGEMENTS .................................................................................................. 33 REFERENCES ...................................................................................................................... 34 FIGURE CAPTIONS ............................................................................................................ 51


Perfecting oneself through edifying others is an essential qualification of the Bodhisattva or Mahasattva. The basis of this idea lies in the fundamental conception of the oneness of existence which amounts to the same as the universal inherence of the Buddha-nature in all beings, the realization of which being the ultimate aim of Buddhist discipline. This is naturally hampered by the varying capacities and inclinations of individuals, their egoistic illusions and strivings, and the perturbations of the world periods as well It is the life work of a Mahasattva 2± to overcome all these divisions and agrtations on the part of himself and thereby to induce fellow beings to the realization of the same Buddha-nature in all, his ways and efforts following the Buddha's steps as expounded in the Lotus In addition we have seen in the preceding papers how the ways are enunciated in the two books telling the cases of the queen Shoman and the elder Yuima. Now the latter, defying the ordinary distinction of good and bad, of right and wrong, insists emphatically on the need of variations and adaptations in the educative measures of edifying others, and goes on even to say that a veritable Mahasattva shall not shun even what appears evil. Among the gathas stating the acts and works of the elder leader, the following ones enumerate his acts which are apparently vicious


Objective To study the effect of amiodarone combined with pravastatin for non-valvular paroxysmal atrial fibrillation.Methods Ninty-seven cases were randomly divided into treatment group (n=47) and control group(n=50).The control group was treated with amiodarone, and the treatment group with amiodarone plus pravastatin.The frequency of atrial fibrillation occurrence and the duration of atrial fibrillation,the left atrial diameter and C-reactive protein in the two groups were detected before and after treatment.Results The frequency of atrial fibrillation occurrence and the duration of atrial fibrillation after treatment were significantly decreased in the two groups (P0.05).After treatment, the left atrial diameter and C-reactive protein in the treatment group were significantly lower than those in the control group (P0.05).Conclusion Amiodarone combined with pravastatin can reduce the recurrence of paroxysmal atrial fibrillation,which is related to the anti-inflammation of pravastatin.


COAX ELBOW WITH FLEXIBLE SHAPE A PLACE DETERMINED AND FORMING AN ANGLE MAKES WITH A RADIUS OF CURVE PROVIDES FOR HIGH FREQUENCY SIGNAL TRANSMISSION, WITHOUT DETERIORATION OF ELECTRICAL CABLE. ON THE CABLE leaner HIS JACKET AT THE ELBOW TO FORM, ON TRAINS AND FIXED ELBOW ELBOW IN THIS FORM WHICH WAS GIVEN TO USING MATERIAL DURCISSEUR permeating DRIVER OUTER BRAID CABLE. THE MATERIAL IS DURCISSEUR, PREFERABLY, WELDING OR GLUE RESIN.


In the framework of the design and use of the flexible manufacturing systems, it is necessary to ensure the consistency of the data used by the different actors. With this intention, the construction of a repository constitutes an interesting solution. An object oriented approach seems to be well adapted to the design of such a repository. The presented approach is based on a bottom-up and progressive integration of the data managed by different points of view. Starting from the real world data and models produced by several experts, a neutral model is built, based on the semantic of the used data rather than on the formalisms; thus, the evolution and reuse of the model are possible. The proposed meta-model gives the concepts used in the models, and allows the management of the different viewpoints. Finally, an example shows how two viewpoints are integrated.


The study was designed to evaluate the business development and transfer of technologies to small manufacturing companies by research institutes in South Western Nigeria. The study covered all the industrial research institutions with headquarters in South Western Nigeria. The study showed that the involvement of scientists in innovation process was rated highest in the idea generation (4.14) and idea screening (4.29) phases; high in R&D (3.86) and fairly high in pilot plant development (2.71) and commercialization (2.43) phase. Their involvement was rated low in business analysis and development (2.14), and test marketing (2.29) phase. The involvement of engineers was rated highest in idea generation (3.28), fairly high in R&D (2.71), pilot plant development (2.57), and idea screening (2.40) phases. However, their involvement was rated low in business analysis and development (2.0), test marketing (2.0), and commercialization (1.28) phases. The involvement of technology marketers in innovation process was generally rated fairly high in R&D (2.7) and business analysis and development (2.6), and low in all the other phases of innovation. However, their involvement at IAR&T, FIIRO, and NIOMR in all the phases was rated very high (3.0-5.0). The involvement of entrepreneurs was generally rated from fairly high to low (2.7-2.3) in all the phases of innovation. The involvement of financial institutions in all the phases of innovation was generally rated low (1.281.71).


: We present a fully 3D printed, on-fiber hybrid photonic structure to create customizable single-fiber optical tweezers. The structure contains waveguiding, reflecting, and refracting micro-optical elements stacked to generate a high-NA focal spot. Optical tweezers (OT) are non-destructive, contactless tools that use light to trap and manipulate microscopic objects. They have applications in diverse fields, especially in biomedicine and physics [1]. Due to their unique applications and the ability to analyze sub-micron biological systems, the Nobel prize for Physics in 2018 was awarded to Arthur Ashkin, the inventor of OT. Conventional single-beam OT setups require a laser beam focusing with a high-Numerical Aperture (NA) objective. However, these setups are bulky and restrict the trapping capabilities, while the miniaturization of OT unlocks new possibilities such as trapping in turbid media or in-vivo.


Due to the enhancement of sensing technology in recent years, the researcher community embedding it to solve the real-life problems of physical and environmental types. Smart technology needs to be embedded in agriculture and farming to increase the crop to get more economic benefits. Agriculture and farming is core occupation since the human being start living on the earth, and with the passage of time, it is being modernized by using technologies for forming purposes. In the last half-century, due to modernization in technology along with electronics, the way of farming has been modernized and still in progress. Internet of Things (IoT) gives a new aspect in the field of smart farming and agriculture domain. With the use of a smart sensor system embedded with IoT, it revolutionized the way of farming and crop management and made it easy to monitor the agriculture farms. For improving the product and increasing the yield, temperature, moisture, humidity, and pest control are key components to be monitored and controlled. In this research work, an automatic Plant Irrigation System is proposed, which embedded smart sensor systems and IoT for the purpose of monitoring and managing the farm, which automatically provides water to plants and keeps updated by generating a message. In the proposed framework, several features are embedded, e.g., remote monitoring, intruder caring, temperature, and moisture sensing, security, leaf wetness, and irrigation facilities. To control these parameters via IoT, the system is connected with a remote device by interfacing a sensor system with a microcontroller. The proposed system is simulated, and the results are presented in the latter part of this paper, which is very much satisfied for further enhancement of this research work.


At its best, football is a glorious, uplifting, unifying sport. But it hasn't been at its best for some time. Disillusioned by corruption scandals, billionaire club owners and an ever-smaller group of title challengers, Martin Calladine drifted away from the game that had defined 25 years of his life. He found solace in an unexpected place: American football. Despite the glitz and the endless ad breaks, the NFL has a curiously Corinthian purity: preventing teams buying success by sharing TV money equally, having a strict salary cap and, with the draft, letting the worst teams get the pick of the best new players. The Ugly Game is a funny, angry book of essays for football fans setting out where the game has gone wrong and showing that, perhaps surprisingly, the NFL has many of the answers.


Report discussing proper techniques for cultivating sweet potatoes, including suggestions for propagation, harvest, and the prevention of diseases. There is also a discussion of uses of the sweet potatoes and production costs.


A brief sharing some findings from the University of Oregon's descriptive study, "What do they do there? Examination of alternative education schools, programs, and practices for special education students."


The paper highlights the problem of mathematical modeling of the highly complex manufacturing system in which work stations are arranged serially within each production plant. Production plants are located in a parallel way. The specification details and the model resulting from them led to creating the simulator to be employed to solve the problem of realizing customers' orders. Equations of state are given to illustrate the state of the system at each stage. The complex system is controlled by implementing heuristic algorithms. The criteria to be met are defined. The study case is based on randomly generated data and solved by means of the dedicated information tool. The search for the satisfactory solution is carried out either by an increased number of simulation runs or comparing the pairs or combinations of order and plant choosing algorithms. The main goal remains to meet the stated criterion. INTRODUCTION The growth of markets towards globalization results in materialization of automated industries with high performance of manufacturing systems. Traditional manufacturing systems are no longer able to satisfy these requirements. In the global market there is an increasing trend toward achieving a higher level of integration between designed and manufacturing functions in industries to make the operations more efficient and productive (Modrak and Pandian 2012). Effective organization and management of materials, processes and human resources of a company is a prerequisite in today's highly competitive industrial landscape. Key goals are to improve planning and scheduling of processes, increase productivity, minimize inventory level, improve responsiveness to changes in demand, improve quality, and lower operation cost. These problems are solvable with the use of modelling and simulation of such production systems. One of the most useful tools in the arsenal of an operations research (industrial engineering) management science analyst consists in computer simulation. In this case it is necessary to put attention to the benefits resulting from combining both spheres, the one of formalized algorithms and the other one of the human instinct (Neumann 2011). The use of simulation, as a support tool to the operational decision making process, allows us to analyze, from a statistical point of view, the behavior of a production or logistic system that is subject generally to either controllable and or not controllable factors. Through computer simulation it is possible to select those operational decisions that maximize an objective function or a system performance parameter, and to evaluate effects of these decisions without controllable factors variability. An approach to implement efficiently and effectively simulation models in manufacturing systems is deployed in (Chramcov et al. 2011). Currently, a wide range of commercial products which use graphic interfaces (e.g. Arena, Witness, MapleSim 4, AutoMod, Quest, PlantSimulation, etc.) offer an extremely wide spectrum of possibilities for modelling and simulation of manufacturing, logistic and other queuing systems (Rizzoli 2009). Nevertheless, the general language C# has been adopted for creation of our production system simulator because the programming logic cannot be easily expressed in GUIbased systems (Babich and Bylev 1991). The initial specification and consequent modelling of the discussed manufacturing system is described in detail in (Bucki et al. 2012a). This paper is later expanded to the simulation form enabling us to carry out a simple simulation process (Bucki et al. 2012b). The simulation process shows that one of the suggested heuristics minimizes the total order realization time. However, the need to search for the solution to tasks carried out in the complex manufacturing system with buffer stores leads to extending specification details and the subsequent model which finally forms the basics for the simulation process (Bucki 2012). The simulation process is carried out by means of the simulation tool built on the basis of these specification details and the subsequent model (Marusza 2013). GENERAL SYSTEM FORMULATION Let us propose the information system imitating the continuous production process carried out in J work Proceedings 27th European Conference on Modelling and Simulation ©ECMS Webjorn Rekdalsbakken, Robin T. Bye, Houxiang Zhang (Editors) ISBN: 978-0-9564944-6-7 / ISBN: 978-0-9564944-7-4 (CD) stations arranged in a series. We assume that there is a machine in each work station which can perform I operations. However, we assume that only one tool can be determined to perform the operation on the order unit in each work station. We assume there are buffer stores between the work stations. The capacity of each buffer store is limited. Operations are performed in the work stations in sequence. Further, we assume there are more than one identical production systems available. Let us assume that A manufacturing plants are arranged in parallel. This system requires K stages to realize the order elements. The matrix of orders at the k-th stage is considered in the form (1), where k n m z , is the number of conventional units of the n-th order of the m-th customer at the k-th stage. The stage k, k=1,...,K is the moment of making the production decision. [ ] k n m k z Z , = ,m=1,...,M; n=1,...,N; k=1,...,K (1) The order matrix is modified after every decision about production in accordance with the specification (2). ⎪ ⎪ ⎩ ⎪⎪ ⎨ ⎧ − − = − − otherwise. stage, th at the realized is units of number the if 1 , , , 1 , , k n m k n m k n m k n m k n m z k x x z z (2) Some of the charge materials are used for manufacturing products of the specific order. The assignment matrix of ordered products to charges takes the form (3), where n m, ω is the number of charge material assigned to the order n m z , [ ] n m, ω = Ω , m=1,...,M; n=1,...,N (3) Elements of the assignment matrix take values according to (4). ⎪ ⎩ ⎪ ⎨ ⎧ − = otherwise. 0 charge, th the from realized is order the if


With the rapid development of economy in China, environmental problems are increasingly affecting people's daily life and work. Xuecheng area of Shandong Zao Zhuang is one of the oldest coal towns in China. Coal income is one of the main sources of local economy. Heavy dusts, produced by the coal mines and large cement plants, are seriously affecting the air quality index (AQI) and impairing local residents' health. Consequently, people in this area have to reduce their outdoor activities, which has led to loss of the town's vitality. In this paper, based on design strategy, the source of inspiration and medium and from the overall perspective, we design an innovative ecological Street Community Park, applying the concept of "Cradle to Cradle".


We are told 'there is an underlying honesty in the attitudes of these men, a desire to have social justice prevail, and there is stubborn hope for the future. The drudgery, the dirt, and frequently the danger of their occupations may wear them out, but it never seems to diminish theirfaith in the humanityofman, or the capacity for humour' (p.7). If anything, these photographs are too didactic, being redolent with things concerning the strength ofmale bodies, the dignity oflabour and heroic struggle. The men in these photographs stare out at us, their arms akimbo, one leg forward, isolated, their warm faces contrasted with stark and harsh backgrounds. Their readiness for work also indicates a readiness for resist-


Objective: To study the variation of expression of CD4+ CD25+ regulatory T cells and Foxp3 mRNA in patients infected with Helicobacter pylori and its clinical significance.Methods: Changes of expression in 35 H.pylori-negative adults and 45 H.pylori-positive patients and Foxp3 mRNA were analyzed using immunohistochemistry and PCR.Results: The proportion of CD4+ CD25+ regulatory T cells in the gastric mucosa in H.pylori-positive patients(5.012%)was obviously much higher than that of CD4+ CD25+ regulatory T cells in H.pylori-negative patients(0.739%).The level of expression of Foxp3 mRNA was significantly higher than those of H.pylori-negative patients(P 0.01)in gastric mucosa of patients infected with Helicobacter pylori.Conclusion: The patient infected by H.pylori may inhibit specific T-cell response caused by H.pylori through the expression of the up-regulation of CD4+ CD25+ regulatory T cells,resulting in the long-term colonization of H.pylori.


HpD; and the scattering characteristics of the laser beam used with or without a light scattering medium. These experiments are part of a research project with the aim of developing a photoradiotherapy method for the treat ment of multifocal bladder cancer.


The samples made from a SiC-C/SiC composite were pretreated in Ar under creep,fatigue, creep and fatigue interaction, as well as in dry oxygen and wet oxygen under fatigue at 1300℃ for 15 hours. The fracture behaviors of the pretreated samples were investigated at 1300℃. The loading-strain curves and the microstructures of the sample were compared with each other. The various of high temperature tensile behaviors was attributed to the different microstructures resulted from different high temperature pretreatments.


Internet has become the main channel of information on investment for individual investors."market trend" is a major consideration for individual investors to investment market.Here to try to design the opinion mining system of stock,the system uses model-based method of tendentious analysis of stock analysts,to identify and extract the predictable view of statement classification and tendentious analysis of the final stock analysts.The experiment results show that the use of the approach makes the opinion mining system's precision rate arrive at 91.7%.


The propulsion apparatus for a vessel and a method for installing them are disclosed. The propulsion apparatus for a vessel according to an embodiment of the present invention includes a rear propeller fixed to the rotating shaft; A rotatably supported by the axis of rotation of the rear propeller front forward propeller; By inverting the rotation of the rotary shaft reverse rotation device for transmitting to the front propeller; including, but inverting the rotation device is a gearbox is accommodated in the tail formed footprint of the hull in a state in which a built-in plurality of gears to implement inversion of the forward propeller It includes, and the installation space may be formed in a width larger than the longitudinal width of the gearbox apply tolerances.


This study tried to explore the influence of teaching reading comprehension utilizing the principles of genre analysis. In conducting the present study, 53 homogenous EFL Students were selected out of the 73 0nes as the subjects of the study and were divided randomly into two groups of experimental and control. Experimental group has composed of 27 language learners with 14 females and 13 males; and the control group included 26 language learners with 13 females and 13 males. Ten reading passages were instructed to the selected subjects during thirty hours-the experimental group using a genre based instruction and the control group using the traditional approach usual in teaching reading comprehension. The results of the study revealed that those who received a genre-based instruction performed better than those students taught reading based on traditional reading. In terms of gender, the study showed non-significant and trivial differences between the performances of the two genders.


A new 9 methylacridine, fluorescent material, is synthesized by microwave radioation, frequency and time of microwave radiation are also discussed. In addition, its fluorescent property is studied.


This paper considers two commuting smooth transformations on a Banach space, and proves the sub-additivity of the measure theoretic entropies under mild conditions. Furthermore, some additional conditions are given for the equality of the entropies. This extends Hu's work about commuting diffeomorphisms in a finite dimensional space (Huyi Hu, 1993, Ergod. Th. Dynam. Sys., \textbf{13}: 73-100) to the case of systems on an infinite dimensional Banach space.