A clean incineration system of refuse and organic wastes and a device thereof relate to refuse incineration equipment. The incineration system mainly consists of an dry fan, a gas phase circulating incinerator, an air preheater, a dedusting/purification device, an induced draft fan and a chimney, a discharge outlet of the dry fan is connected to a feed inlet of the incinerator, a fume outlet of the incinerator is connected to the air preheater, the air preheater is connected to an air supply outlet of the dry fan, a suction opening of the dry fan is connected to a fume inlet of the dedusting/purification device, and a fume outlet of the dedusting/purification device is connected to the chimney by the induced draft fan. A dry distillation zone and a gasification zone form a gasification environment, and a first combustion zone and a second combustion zone form a combustion environment in the gas phase circulating incinerator, and a circulating air conduit and a circulating fan form a gas phase circulation loop outside the incinerator. Refuse fuel is gasified in the incinerator for combustion, and gaseous material generated in the gasification environment is allowed to have circulating gasification and combustion. The system and the device have the advantages of high burnout ratio, few pollutants generated from combustion and clean incineration of refuse.


We briefly survey our recent results about the Mumford goodness of several canonical metrics on the moduli spaces of Riemann surfaces,including the Weil-Petersson metric,the Ricci metric, the Perturbed Ricci metric and the Kahler-Einstein metric.We prove the dual Nakano negativity of the Weil-Petersson metric.As applications of these results we deduce certain important results about the L~2-cohomology groups of the logarithmic tangent bundle over the compactifled moduli spaces.


The invention relates to the technical field of a wine drink, in particular to a production method of rhodiola highland barley tea wine. The production method of the rhodiola highland barley tea wine comprises the following steps: 1) soaking; 2) decocting tea juice; 3) decocting white granulated sugar syrup; 4) decocting honey syrup; and 5) blending to obtain finished rhodiola highland barley tea wine. According to the method provided by the invention, highland barley wine produced by highland barley is used for immersing and extracting rhodiola crude medicine, tea polyphenol and strong tea aroma in tea leaves are extracted, the wine and the tea are scientifically integrally mixed by modern technology, the tea wine is combination of conventional wine culture and tea culture, the tea wine is smelt as tea and drunk as wine and has tea aroma and wine aroma when savoring. The preparation method is a big break in brewing history and a big innovation in tea ceremony history. Particularly, multiple nutrient substances in the highland barley raw material, the rhodiola and the tea leaves, which are beneficial for human body, are maintained furthest by utilizing a specific production process, in particular beta-glucan and flavonoid substances are maintained, and tea drinks processed by other juice and barley raw materials are incomparable with the wine drink.


The purpose of the study was to determine whether peer education using group approach focusing on knowledge and practice aimed at improving the insertion and management of peripheral intravenous catheter and procalcitonin detection could decrease the rate of peripheral intravenous catheterrelated blood stream infections and associated complications. . Subjects and Methods: This study was conducted during nine months from January 2010 to September 2010 in medical, surgical, neurology, and orthopedic departments at Mansoura University Hospitals. Two categories of subjects were included in the study; ANurses, including (8 peer trainers, were selected based on certain criteria and 60 trainees). B-130 Patients.Three research tools were used in the study: 1-Nurses' Knowledge questionnaire regarding the insertion and management of peripheral intravenous catheter and peripheral intravenous catheterrelated blood stream infections and associated complications.2Nurses' practice checklist regarding the correct procedures for the insertion and management of peripheral intravenous catheter, and 3-Surveillance of patients with peripheral intravenous catheterrelated blood stream infections and associated complications. Results: There was a significant increase of peer trainers and trainees 'knowledge and practice in all items before and after training (p<0.05) .There was a significant reduction in the percentage of infections in the surgical and Medical departments (p value was < 0.001 and 0.009) while there were no significant reduction in the percentage of infections in both neurosurgery and orthopedic departments. The total isolated organisms from PCABSI were 61 microorganisms most of them were Gram negative .Detection of procalcitonin by EIA showed that there was significant high level among patients with Gram negative bacterimia versus patients with Gram positive and also patients with candidal bacterimia (P-value < 0.001). Limitations for the study: This study was based only on peer trainers and trainees of Mansoura University hospitals, so, findings can not be generalized for peer trainers and trainees of all university hospitals. Conclusion: Based on the findings of this study, peer education program and procalcitonin detection was found to be effective in improving knowledge and practices of both trainers and trainees, reduction in the percentage of infections in the surgical and medical departments and no significant reduction in the percentage of infections in both neurosurgery and orthopedic departments. Recommendations: Training for peer educators needs to be an on-going process; refresher and more advanced training should be offered periodically. Retesting study should be done on a larger sample using a control group. A follow-up study could describe the aspects of the relationship that seem important from both the trainers and the trainee's perspective, this data could be used to further refine effective teaching and learning protocols. More research is necessary to assess long-term impact evaluations. A broader study across several health institutions is also recommended so as to get a sample that will be the best representative of all nurses' level could reduce morbidity and the costs of care associated with catheter-related bloodstream infections.It is hoped that this study will help in planning and improving policies for addressing issues related to the insertion and management of peripheral intravenous catheter at Mansoura University hospitals. [Karima F Elshamy and Maggie R Mesbah Effects of Peer Education Intervention and Procalcitonin Detection on Peripheral Intravenous CatheterRelated Blood Stream Infections and Associated Complications among Selected Patients at Mansoura University Hospitals, Egypt] Journal of American Science 2011; 7(10): 362-372].(ISSN: 1545-1003). http://www.americanscience.org.


Abstract: Adders are one of the most widely used digital components in digital integrated circuit design. With the advances in technology, the design that offers either high speed, low power consumption, less area, or a combination of them is designed. There are various processes performed by the digital circuits among which arithmetic operations are prominent. Three-operand binary adder is the basic functional unit to perform the modular arithmetic in various cryptography and pseudorandom bit generator (PRBG) algorithms. Carry save adder (CS3A) is the widely used technique to perform the three-operand addition. However, the ripple carry stage in the CS3A leads to a high propagation delay. Moreover, a parallel prefix two-operand adder such as Han-Carlson (HCA) can also be used for three-operand addition, significantly reducing the critical path delay at the cost of additional hardware. Hence, a new high-speed and area-efficient adder architecture is designed using pre-compute bitwise addition followed by carry prefix computation logic to perform the three-operand binary addition that consumes substantially less area, low power, and drastically reduces the adder delay. To design a faster computing system with less hardware we require some other architecture. The proposed architecture will reduce the area as well as the delay by replacing the Han-Carlson adder with the Ladner fisher adder in a Highspeed area-efficient three-operand binary adder. The proposed architecture is synthesized with the zynq-7000 library. The proposed architecture reduces the LUT count and delay by 20 and 0.4 nanoseconds respectively. By using these synthesis results, we noted the performance parameters like the number of LUTs and delay. We compared the adders in terms of LUTs (represents area) and delay value


The article shows possible causes of alopecia development in children. The methods of treatment used at present time are described.


Objective—Insulin resistance of vascular smooth muscle cells (VSMCs) has been linked to accelerated atherosclerosis in diabetes; however, the effects of insulin on VSMCs remain controversial. Most VSMC insulin receptors are sequestered into insulin-insensitive hybrids with insulin-like growth factor-1 receptors (IGF1Rs). Thus we hypothesized that regulation of IGF1R expression may impact cellular insulin sensitivity. Methods and Results—IGF1R expression was increased in aortas from diabetic mice. IGF1R overexpression in VSMCs impaired insulin-induced Akt phosphorylation. Conversely, IGF1R downregulation by siRNA allowed assembly of insulin holoreceptors, enhanced insulin-induced phosphorylation of its receptor, Akt, Erk1/2, and further augmented insulin-induced glucose uptake. IGF1R downregulation uncovered an insulin-induced reduction in activation of NF-&kgr;B and inhibition of MCP-1 upregulation in response to TNF-α. Conclusions—Downregulation of IGF1R increases the fraction of insulin receptors organized in holoreceptors, which leads to enhanced insulin signaling and unmasks potential antiinflammatory properties of insulin in VSMCs. Therefore, IGF1R, which is susceptible to feedback regulation by its own ligand, may represent a novel target for interventions designed to treat insulin resistance in the vasculature.


OBJECTIVES
To compare the bactericidal activity of besifloxacin, moxifloxacin and gatifloxacin and determine the contribution of the preservative benzalkonium chloride (BAK) to bactericidal activity.

METHODS
Time-kill experiments were performed against four species (n=12) with besifloxacin, moxifloxacin and gatifloxacin, in the presence or absence of BAK, at t=0, 5, 15, 30, 45, 60, 120 and 360 min, according to standard CLSI methods.

RESULTS
In the presence of BAK, bactericidal activity was observed within 5 min, regardless of the fluoroquinolone tested. The bactericidal activity of BAK was unaffected by the concurrent presence of besifloxacin and rapid killing (within 5 to 15 min) was not observed at BAK concentrations below 50 mg/L. However, when tested without BAK, besifloxacin was bactericidal in as little as 45 min, while moxifloxacin and gatifloxacin required at least 120 min; besifloxacin kill rates against fluoroquinolone-susceptible and -resistant strains were at least 2- to 4-fold faster than those of gatifloxacin or moxifloxacin.

CONCLUSIONS
Besifloxacin was the most rapidly bactericidal fluoroquinolone tested, followed by gatifloxacin and moxifloxacin, both of which had similar activity. Our studies demonstrate that the previously reported rapid in vitro killing by gatifloxacin formulations was probably due to the concurrent presence of 50 mg/L BAK, which is much higher than the 3.2 mg/L BAK observed in human tears 1 min after instillation of ophthalmic gatifloxacin solutions [Friedlaender MH, Breshears D, Amoozgar B et al. The dilution of benzalkonium chloride (BAK) in the tear film. Adv Ther 2006; 23: 835-41].


Physical education must meet the needs of the social development for the 21st Century in colleges and Universities,this paper has been discussed the guiding ideology, goal, type of physical curriculum installing, teaching content and method, the teachers'fine examplary role and so on,to speed up teaching reform's step constantly and improve teaching quality.


Abstract Traditional breeding and molecular approaches have been used to develop tobacco varieties with reduced nicotine and secondary alkaloid levels. However, available low‐alkaloid tobacco varieties have impaired leaf quality likely due to the metabolic consequences of nicotine biosynthesis downregulation. Recently, we found evidence that the unbalanced crosstalk between nicotine and polyamine pathways is involved in impaired leaf ripening of a low‐alkaloid (LA) Burley 21 line having a mutation at the Nic1 and Nic2 loci, key biosynthetic regulators of nicotine biosynthesis. Since the Nic1 and Nic2 loci are comprised of several genes, all phenotypic changes seen in LA Burley 21 could be due to a mixture of genetics‐based responses. Here, we investigated the commercial burley variety TN90 LC and its transgenic versions with only one downregulated gene, either putrescine methyl transferase (PMT‐RNAi) or PR50‐protein (PR50‐RNAi). Nicotine levels of cured lamina of TN90 LC, TN90 PMT‐RNAi and TN90 PR50‐RNAi, were 70.5 ± 3.8, 2.4 ± 0.5, and 6.0 ± 1.1 mg/g dry weight, respectively. Low‐alkaloid transgenic lines showed delayed leaf maturation and impaired leaf quality. We analyzed polyamine contents and ripening markers in wild‐type TN90 control plants (WT) and the two transgenic lines. The ripening markers revealed that the PMT‐RNAi line showed the most pronounced impaired leaf maturation phenotype at harvest, characterized by higher chlorophyll (19%) and glucose (173%) contents and more leaf mesophyll cells per area (25%), while the ripening markers revealed that maturation of PR50‐RNAi plants was intermediate between PMT‐RNAi and WT lines. Comparative polyamine analyses showed an increase in free and conjugated polyamines in roots of both transgenic lines, this being most pronounced in the PMT‐RNAi plants. For PMT‐RNAi plants, there were further perturbations of polyamine content in the leaves, which mirrored the general phenotype, as PR50‐RNAi transgenic plants looked more similar to the WT than PMT‐RNAi transgenic plants. Activity of ornithine decarboxylase, the enzyme that catalyzes the committing step of polyamine biosynthesis, was significantly higher in roots and mature leaves of PMT‐RNAi plants in comparison to WT, while there was no increase observed for arginine decarboxylase. Treatment of both transgenic lines with polyamine biosynthesis inhibitors decreased the polyamine content and ameliorated the phenotype, confirming the intricate interplay of polyamine and nicotine biosynthesis in tobacco and the influence of this interplay on leaf ripening.


Grid integration of a laboratory scale Doubly Fed Induction Generator (DFIG) has been carried out and reported here. The stator of the DFIG is directly connected to the grid and the rotor is interfaced to the grid through a pair of back to back converters (rectifier and inverter). A low cost control scheme using sinusoidal pulse width modulation (SPWM) technique is used in the inverter to match the rotor voltage, phase and frequency with those of the grid and also to facilitate power transfer by creating a phase shift. Complexity in the interface controller is avoided as it allows only super synchronous generation. The scheme has been successfully validated in laboratory and the results are presented here.


We study the total and dark matter (DM) density profiles as well as their correlations for a sample of 15 high-mass galaxy clusters by extending our previous work on several clusters from Newman et al. Our analysis focuses on 15 CLASH X-ray-selected clusters that have high-quality weak- and strong-lensing measurements from combined Subaru and {\em Hubble Space Telescope} observations. The total density profiles derived from lensing are interpreted based on the two-phase scenario of cluster formation. In this context, the brightest cluster galaxy (BCG) forms in the first dissipative phase, followed by a dissipationless phase where baryonic physics flattens the inner DM distribution. This results in the formation of clusters with modified DM distribution and several correlations between characteristic quantities of the clusters. We find that the central DM density profiles of the clusters are strongly influenced by baryonic physics as found in our earlier work. The inner slope of the DM density for the CLASH clusters is found to be flatter than the Navarro--Frenk--White profile, ranging from $\alpha=0.30$ to $0.79$. We examine correlations of the DM density slope $\alpha$ with the effective radius $R_\mathrm{e}$ and stellar mass $M_\mathrm{e}$ of the BCG, finding that these quantities are anti-correlated with a Spearman correlation coefficient of $\sim -0.6$. We also study the correlation between $R_\mathrm{e}$ and the cluster halo mass $M_{500}$, and the correlation between the total masses inside 5\,kpc and 100\,kpc. We find that these quantities are correlated with Spearman coefficients of $0.68$ and $0.64$, respectively. These observed correlations are in support of the physical picture proposed by Newman et al.


The main measures to prevent the spread of the COVID-19 virus in long-term institutions for elderly people should be based on the principle of social distancing and on limiting direct physical contact between older residents and their families. In this regard, the system of nursing care for the elderly residents of long-term care institutions is forced to reorganize in order to provide residents and their families with adequate quality care, while ensuring infection safety.


ences (were it not, it would be trivial), but the presentation of data in quantitative form does not warrant the conclusion that the inferences are the result of a process as rigorous as the content analysis. They are not, and because they are not we finally put down the book with a mingled sense of deja vu and mild disappointment: deja vu because many of the conclusions are reminiscent of those reached earlier by students of popular heroes (including the businessman), mild disappointment because, for all the rigor of the content analysis, so many of the questions asked of the data derive from an almost unquestioning acceptance of current ideas that are more fashionable than profound. Life was never so simple as the journalists of yesteryear, whose writings Professor Greene analyzes, would have had us believe; nor is it so simple as it appears in the writings of so many of the sociologists and historians whose interpretations provide the basis of so many of Professor Greene's ad hoc conclusions. * # *


Since the quality factor of an acoustic wave resonator (AWR) reached 1011, AWRs have been regarded as a good carrier of quantum information. In this paper, a scheme to construct a NOON state with two AWRs assisted by a nitrogen‐vacancy‐center ensemble (NVE) is proposed. The two AWRs cross each other vertically, and the NVE is located at the center of the crossing. By considering the decoherence of the system and using resonant interactions between the AWRs and the NVE, and the single‐qubit operation of the NVE, a NOON state can be achieved with a fidelity higher than 98.8% when the number of phonons in the AWR is N≤3 .


Nowhere is China's aid program both more important and yet less understood than with North Korea. This article examines two puzzles: China's aid to North Korea coexists with a discriminatory trading relationship, and China continues to provide aid even as it tightens economic sanctions on North Korea's nuclear program.


In this empirical study the author describes how the Dutch approach to outlaw motorcycle gangs has changed since the 1970s


Epidemiological studies have linked exposure to traffic‐related air pollutants to increased respiratory and cardiovascular morbidity and mortality. Evidence from human, animal, and in vitro studies supports an important role for oxidative stress in the pathophysiological pathways underlying the adverse health effects of air pollutants. In controlled‐exposure studies of animals and humans, emissions from diesel engines, a major source of traffic‐related air pollutants, cause pulmonary and systemic inflammation that is mediated by redox‐sensitive signaling pathways. Assessment of human responses to traffic‐related air pollution under realistic conditions is challenging due to the complex, dynamic nature of near‐roadway exposure. Noninvasive measurement of biomarkers in breath and breath condensate may be particularly useful for evaluating the role of oxidative stress in acute responses to exposures that occur in vehicles or during near‐roadway activities. Promising biomarkers include nitric oxide in exhaled breath, and nitrite/nitrate, malondialdehyde, and F2‐isoprostanes in exhaled breath condensate.


We present a new fabrication method, called ''vertical spin coating,'' to prepare highly oriented J aggregates dispersed in polymer films. Linear dichroic spectra of the oriented J aggregate of 1,1'‐diethyl‐2,2'‐quinocyanine bromide PIC‐Br were measured at 5 K. The dichroic ratio at the peak of J band was 5 to 10, dependent on the preparation conditions. Precise measurement of the dichroism at the J band revealed that the J band is composed of two bands with transition dipole moments perpendicular to each other. The films are stable even at room temperature, and have applications as nonlinear optical devices.


Cesar Ritz and his hotels the building of the Ritz the search for luxury life below stairs life in the Ritz new ownership.


In this note we prove that, if $S_n$ is the greatest area of a rectangle which can be covered with $n$ unit disks, then $2\leq S_n/n<3 \sqrt{3}/2$, and these are the best constants; moreover, for $\Delta(n):=(3\sqrt{3}/2)n-S_n$, we have $0.727384<\liminf\Delta(n)/\sqrt{n}<2.121321$ and $0.727384<\limsup\Delta(n)/\sqrt{n}<4.165064$.


Abstract: In The Formation of Q, Kloppenborg identifies three redactional layers in the Sayings Gospel Q: the "formative stratum" (or Q1), the "main redaction" (or Q2), and the "final recension" (or Q3). He ascribes Q 14:16–24 to the main redaction. As an alternative, this article argues that the passage in question appeared in the formative stratum before it was incorporated into the main redaction.


In this paper, we investigate a Timoshenko‐type system of thermoelasticity of type III in the presence of a distributed delay. We prove the well‐posedness and two exponential stability results in the presence as well as in the absence of an extra frictional damping.


Hay feeding might have some advantaged in relation to herd health and reduces the risk for contamination of the milk with spores. Hay production compared to silage is more resource intensive – like use of energy for drying. Hay from two types of herb enriched grass swards and the traditional grassland showed no difference in intake or milk production when compared at three organic farms. Feed efficiency tended to be lower than standards based on silage feeding.


The objective of this work was to evaluate the yield of coriander Verdão subjected to nitrogen and phosphorus doses in the edaphoclimatic conditions inherent to the municipality of CratoCE. The experimental design was randomized blocks in a 4x4 factorial scheme, with three replications, totalizing 48 observations. The first factor consisted of the doses of phosphorus (0, 5, 10 and 20 g) and the second by nitrogen doses (0, 2, 4 and 8 g). The variables analyzed were: plant height, number of plants/m2, fresh mass of aerial part/m2, root mass/m2 and mass per plant. The results showed that the nitrogen factor significantly influenced the variables plant height, shoot mass per square metre and mass per plant. The effect of phosphorus was positive to increase the root area. Nitrogen applications provided additions of 57.6; 55.4 and 35.8% for plant height, aerial part mass per square metre and mass per plant, respectively. The tests of the phosphorus doses showed that the application of 9.82% provided the growth of 148.19, while the dose of 10.57% of P, increased the plant biomass in 969.8 g. The use of nitrogen contributed to the greater development of the plants, Demonstrated that the use of this mineral is extremely important to obtain better productivity indexes. The dose of 8g/m2 of N increased in mass per plant, fresh mass of aerial part and Root mass respectively in 57.6; 55.4 and 35.8% in relation to non-fertilized plants. The use of phosphorus increased the number of plants per square metre, fresh mass of the aerial part per square metre and root mass per square metre.


Abstract The pattern surface structure of a thin blend polymer film of Poly methyl methacrylate (PMMA) – Poly ethylene glycol (PEG) induced by Ar+ ion etching (5 keV) has been investigated by scanning electron microscopy. Blend polymer films have been obtained consisting of a hydrophilic PEG and a hydrophobic PMMA distributed in co-continuous phases. Four different compositions of the two polymers are dissolved in chloroform and irradiated with gamma rays (60Co) at 20 kGy to produce transparent films of blend polymer PMMA-PEG after casting. Self-assembled of PMMA-PEG film is obtained because of the high contrast between the two polymers. Ion-polymer interaction with a hydrophilic polymer (Ar+ +PEG) rather than the high etch resistance of hydrophobic polymer (Ar+ −PMMA) was observed. The results are discussed in terms of significant destruction of bonds in the blend polymer films as a result of which one polymer undergoes rapid dissociation rather than the other one. This means that etching with Ar+ ions of the PMMA domains are stable and PEG can be selective. The ATR-FTIR spectrum shows the absence of hydrogen bonds and XRD/DSC curves show the crystanility of PMMA depending on the PEG contents and gamma radiation effect, irradiated blend polymer PMMA/PEG has shown more resistant at thermal degradation than irradiated PMMA. This indicates that the PEG contents have an effect on the thermal stability of PMMA/PEG as detected by TGA. Finally, the pattern surface of irradiated blend polymer (PMMA-2%PEG) was plated with two coaxial layers subsequently of copper (Cu) and silver (Ag) using sputter technique.


We present WikiSpeech, an ambitious joint project aiming to (1) make open source text-to-speech available through Wikimedia Foundation's server architecture; (2) utilize the large and active Wikipedia user base to achieve continuously improving text-to-speech; (3) improve existing and develop new crowdsourcing methods for text-to-speech; and (4) develop new and adapt current evaluation methods so that they are well suited for the particular use case of reading Wikipedia articles out loud while at the same time capable of harnessing the huge user base made available by Wikipedia. At its inauguration, the project is backed by The Swedish Post and Telecom Authority and headed by Wikimedia Sverige, STTS and KTH, but in the long run, the project aims at broad multinational involvement. The vision of the project is freely available text-to-speech for all Wikipedia languages (currently 293). In this paper, we present the project itself and its first steps: requirements, initial architecture, and initial steps to include crowdsourcing and evaluation.


Frederick Lewis Allen was one of the pioneers in social history. Best known as the author of Only Yesterday, Allen originated a model of what is sometimes called instant history, the reconstruction of past eras through vivid commentary on the news, fashions, customs, and artifacts that altered the pace and forms of American life. The Big Change was Allen's last and most ambitious book. In it he attempted to chart and explain the progressive evolution of American life over half a century. Written at a time of unprecedented optimism and prosperity, The Big Change defi nes a transformative moment in American history and provides an implicit and illuminating perspective on what has taken place in the second half of the twentieth century.


Rasmussen's encephalitis is a chronic inflammatory disease of unknown origin affecting one cerebral hemisphere. We report a case of a seven year old boy who presented with unilateral seizures and progressive hemiparesis. J Nepal Paediatr Soc 2015;35(3):295-297


Objectives To evaluate the reliability of a novel segmentation-based volume rendering approach for quantification of benign central airway obstruction (BCAO). Design A retrospective single-center cohort study. Setting Data were ascertained using electronic health records at a tertiary academic medical center in the United States. Participants and inclusion Patients with airway stenosis located within the trachea on two-dimensional (2D) computed tomography (CT) imaging and documentation of suspected benign etiology were included. Four readers with varying expertise in quantifying tracheal stenosis severity were selected to manually segment each CT using a volume rendering approach with the available free tools in the medical imaging viewing software OsiriX (Bernex, Switzerland). Three expert thoracic radiologists were recruited to quantify the same CTs using traditional subjective methods on a continuous and categorical scale. Outcome measures The interrater reliability for continuous variables was calculated by the intraclass correlation coefficient (ICC) using a two-way mixed model with 95% confidence intervals (CI). Results Thirty-eight patients met the inclusion criteria, and fifty CT scans were selected for measurement. The most common etiology of BCAO was iatrogenic in 22 patients (58%). There was an even distribution of chest and neck CT imaging within our cohort. The average ICC across all four readers for the volume rendering approach was 0.88 (95% CI, 0.84 to 0.93), suggesting good to excellent agreement. The average ICC for thoracic radiologists for subjective methods on the continuous scale was 0.38 (95% CI, 0.20 to 0.55), suggesting poor to fair agreement. The kappa for the categorical approach was 0.26, suggesting a slight to fair agreement amongst the raters. Conclusion In this retrospective cohort study, agreement was good to excellent for raters with varying expertise in airway cross-sectional imaging using a novel segmentation-based volume rendering approach to quantify BCAO. This proposed measurement outperformed our expert thoracic radiologists using conventional subjective grading methods.


First to fourth gate driver ICs G1 to G4 to be connected to a gate line 18 of a drive element 21 are arranged along a side of a liquid crystal display 2. Along a side of the first to four gate driver ICs G1 to G4, a FPC 5 for receiving signals is arranged. A first bus line 15 that branches between the first and second gate driver ICs G1 and G2 connects gate-low terminals 11b and 11a of the first and second gate driver ICs G1 and G2, respectively, to the FPC 5. A second bus line 16 that branches between the third and fourth gate driver ICs G3 and G4 connects gate-low terminals 11b and 11a of the third and fourth gate driver ICs G3 and G4, respectively, to the FPC 5. Gate-high terminals 10b and 10a, logic terminals 12b and 12a, and signal terminals 13 of the second and third gate driver ICs G2 and G3 are connected to the FPC 5. Gate-high terminals 10a and 10b, logic terminals 12a and 12b, and signal terminals 13 of the first and fourth gate driver ICs G1 and G4 are connected to corresponding terminals of the second and third gate driver ICs G2 and G3.


The present volume, even more than the former one, requires a syndicate of experts to review it properly. Merely as a collection of material it is probably quite without parallel; and however much one may differ from some of the author's conclusions, the service he has rendered to scholarship and anthropology passes estimation. The work is almost as important for the study of Roman as for that of Greek religion ; and on one subject after another we have a very complete collection and discussion of evidence and of previous views, which would otherwise have to be sought in the most diverse quarters, and of which a considerable proportion appears here for the first time. The illustrations, as before, are excellent, and include figures of a great number of unpublished objects, many from the author's own collection; and special attention should be called to those contained in the folder at the end of the volume, particularly to the fine reconstructions of the Zeus Olympios and A thena Parthenos and Pheidias. The volume is especially rich in figures of coins, and Dr. Cook's interpretations of these will no doubt receive the careful consideration of numismatists; with these, as with many other aspects of the work, I am not competent to deal.


A 70 year-old Japanese man noticed a dark-red skin plaque (3 cm in diameter) on his right hip about 25 years ago. The plaque grew gradually upto a fist-sized irregularshaped elevated skin lesion and in recent 5 years the lesion repeated growth and retardation. The lesion was examined 3 times and diagnosed as malignant lymphoma at 67 year of age, 69 year of age and 70 year of age, revealing the same histology. Histologically large anaplastic cells showed Pagetoid intraepidermal growth associating polyclonal T and B cell infiltration in dermis. The large anaplastic cells were CD2+ CD3- CD4- CD5+ CD7+ CD8+ CD25+ CD30+ CD56- T-cells. CD8 Ki-1-posotive large anaplastic cell lymphoma (LAC) was diagnosed. PCR analysis of the DNA extracted from the large anaplastic cells in paraffin section showed oligoclonal bands of T-cell receptor gene B chain, suggesting a neoplastic nature of the cells. But the skin lesion showed involution into small one without any therapy. Dermatologically this lesion was diagnosed as solitary type Pagetoid reticulosis (Woringer-Kolopp disease), because of a long clinical course. Considering the clinical course and the examination results, secondary epidermotrpic large anaplastic cell lymphoma in solitary type Pagetoid reticulosis was suggested. Pagetoid reticulosis might be one of the precurssor lesions of cutaneous Ki-1-positive large anaplastic cell lymphoma.


Iran's legislator allows the sides of a commercial contract to set an arbitration agreement for resolution of probable disputes. This arbitrator can be chosen by the sides of a contract or by the court. However, the important point here is that Iran's legislator has set certain conditions for the selected arbitrator. For example the arbitrator should have independence and he or she should also be fair. In addition, the nationality of the arbitrator should be taken into account as well. Furthermore, Iran's legislator has set other conditions for arbitrators. For example there are limitations in terms of selection of arbitrators. Therefore, in this research it has been tried to investigate the legal requirements of arbitrators from the point of view of Iranian laws.


The future wireless communication networks demand the ability to provide tailored services on whenever and wherever basis. The Drone Small Cells (DSCs) provide unique opportunity to cater for such demands thanks to cost efficient robust and quick deployment. Non-Orthogonal Multiple Access scheme with its share of benefits such as spectral efficiency, balanced, and simultaneous multiple user access, is proposed as an ideal candidate for future DSCs. Among many challenges faced by this merger, this paper exploits the extra degrees of freedom of mobility of the drone-Base Station and formulate the problem of user-fairness maximization as a function of drone's altitude under individual rate constraint when a conventional Orthogonal Multiple Access is deployed. The performance of the proposed method is proved through Jain's fairness index for different environment profiles and coverage region. The results show that NOMA not only maximizes fairness between users but also increases the sum rate of the system.


According to an embodiment of the parallax barrier of the present invention is arranged by a plurality of pixels constituting the unit, and the display side of the display panel of n views. The parallax barrier has a plurality of unit pixels corresponding to the plurality of light transmitting portions and a plurality of light-shielding portions, the n is an integer of 2 or more, p is a divisor of n, p is a value of n except q, q is from minus 1 as the value m, is repeatedly arranged in the row direction corresponding to the light transmitting portion corresponding to a unit pixel of the m unit pixels formed by the light shielding portion.


The increasing use of rotary kilns as incinerators or pyrolyser of municipal solid wastes (MSW) has stimulated extensive research efforts to further characterize the bed dynamics of such irregular materials. Experiments concerning the influences of operational variables on the transport process of MSW as well as homogenous sand are conducted in a continuous technical--scale rotary kiln. The results indicate the residence time of particulates is not a certain value, but a function approximately subjected to normal distribution. The irregular MSW has a longer mean residence time (MRT) and a lower material volumetric flow (MVF) than sand, because of its higher θ d.The increment of both rotating rate and kiln slope monotonously reduces MRT and increases MVF.The exit dam has a significant effect on MRT, while the influence of internal structure consisting of various longitudinal ribs and circular ribs is mainly dependent on the height of circular ribs.The roughness of wall also has an effect on MRT through changing the motion regime of bed.


The Cherenkov detector is a key element of the particle identification system in the VES fixed target experiment at IHEP (Protvino). It consists of a 1.6 m R-22 gas radiator and a system of 28 mirrors with photomultiplier tubes (PMTs) as photon detectors. This paper is giving an overview of a description of the detector design, its model used in a simulation, particle identification algorithm, and discussing procedures of obtaining calibration constants. The particle identification performance is demonstrated with the Monte-Carlo and experimental data analyses.


This paper describes what is probably the largest data base to date for music research, specifi- cally a file of the opening melodies (known as incipits) of Renaissance Italian polyphonic pieces, each assigned a discrete serial number along with Information on composer, title, genre, source, and the researcher's initials. The file is open to all musicologists and is structured to permit additions, changes, or deletions of incipits or whole compositions, from all repertories of Western music, past and present. The music representation (DARMS) used for encoding and entering melodies into the data file is briefly described as well as the special music typography for the line printer unique to this project, which has been developed to print melodies in different arrangements and formats. With this data base and its I/O capabilities, it is possible to print camera-ready copy for book publications as well as maintain a computer file at Binghamton which is accessible to researchers. The paper concludes with a brief discussion of areas needing further research, including the use of interactive display terminals, a network for use by scholars, and mathematical studies of melody as wave form.


Purpose – The purpose of the paper is to examine shipping markets exposed on severe competition after Lehman Brothers crisis in 2008, and...


Objective: This review aims to determine the impact of different drugs and methods on the successful establishment of an animal model for chemical phlebitis (CP). Design: Search the Cochrane Library, ProQuest Academic Journal Library, PubMed, Web of Science, Ovid, Embase, CINAHL complete (EESCO) and other related databases to determine the literature. Screen out articles consistent with this review and summarize them. Results: Since the establishment of the database, a total of 1463 articles have been retrieved. After reading the title, abstract and full text, and excluding non-related and duplicate articles, 22 reports were finally included. Among them, there are 8 articles using different medication methods to compare the effects of establishing a CP model. The included articles explored the effects of different animal models, drug types, and their dose, concentration, speed, and time on the CP model. Conclusion: The factors of dose, concentration and time were positively correlated with the incidence of CP. The effect of speed factors on CP and the results of different animal models are inconsistent. It requires further research in the future.


Eight-year-old Theodosia explains to her teacher that she understands why students are told to be very quiet in the l M A X theater, because a whisper can be heard from one end of the theater to the other. "The ceiling is a parabola," Theodosia states. She has learned about parabolas from a lesson on sound at the Reuben H. Fleet Science Center. W here is this happening? In San Diego, California, 800 public school students from the inner city are attending a program called School in the Park (SITP), for approximately one-fourth of their 3rd-, 4th-, and 5thgrade education. This unique program blends rigorous academic standards (formal learning) with hands-on, experiential curricula (informal learning), using community resources at 10 institutions within San Diego's famous Balboa Park. From 6 to 9 weeks a year, these students study at the park's museums (and the San Diego Zoo) with museum educators. This dynamic teaching /learning context fosters students' active engagement in authentic, multi-sensory, purposeful exploration and study, and is carefully articulated with state education standards. Exciting? Sure. Effective? Without a doubt. Since the inception of School in the Park seven years ago, SITP students' standardized test scores have consistently risen. But why? What are the guiding learning principles that drive its success?


From the natural conception of unification of man an d nature, regional property and other aspects of settlement the natural spirit of humanities embodied in rural settlement culture is elaborated; at the same time the modern settlement environment is still analyzed. Author points out that the rural settlement culture will return to modern settlement environment.


With a focus on online consumer behavior in highly-wired countries (the United States, the Netherlands, and South Korea), this study attempted to identify and compare predictors of e-commerce activities in three areas — finance, product, and entertainment. The cross-national comparison revealed that users in each country did not have a compatible pattern of predictors in e-commerce activities. Although an age, web experiences, and a motivation of having less pressure were common predictors, there existed different social and cultural impacts on online consumer behaviors in each country. The main implication of this exploratory crossnational comparative study for e-commerce is that there are both global and local determinants of online consumer behavior. Therefore, researchers and practitioners should consider both


The initial agenda of Methodism as a renewal movement in the Church of England was 'to reform England, especially the church, and to spread scriptural holiness throughout the land'. Like most renewal movements in the history of Christianity, it did not succeed. Instead it morphed into a network of Methodist denominations across the world. 'The people called Methodists' outlines John Wesley's new version of Christianity and its separation from the mother church. It describes the search for succession, the process of ordination, and the core elements of Methodism. Methodists insist on the sacraments of baptism and Eucharist, and on orderly ordination for their clergy. But beyond that there is flexibility, innovation, and adaptability.


When a low‐level narrow‐band noise is placed near the frequency of a sinusoid, the pitch of the tone is displaced away from that of the noise. The shift may be 30 Hz at 800 Hz for a 10‐Hz separation between tone and noise. One theory suggests that the shift occurs because the signal/noise ratio is highest in a filter whose center frequency is displayed away from that of the noise. The optimum displacement depends on the filter shape. Is the displacement dependent on frequency or pitch? If on frequency, the filter may depend on physical mechanisms; if on pitch, the mechanism is more probably neural. Diplacusis permits the separation of pitch and frequency. Over some ranges, the pitch changes more for a given change in frequency in one ear than in the other. Filter displacements over such frequency ranges would be the same for either ear if frequency were primary, but would differ according to the change in diplacusis if pitch were primary. Preliminary results are inconclusive, but suggest that pitch may be more important than frequency.


ABSTRACT Introduction One of the most distinctive hallmarks of cancer cells is increased glucose consumption for aerobic glycolysis, which is called the Warburg effect. In recent decades, extensive research has been carried out to exploit this famous phenomenon, trying to detect promising targetable vulnerabilities in altered metabolism to fight cancer. Targeting aberrant glucose metabolism can perturb cancer malignant proliferation and even induce programmed cell death. Areas covered This review covered the recent patents which focused on targeting key glycolytic enzymes, including hexokinase, pyruvate dehydrogenase kinases, and lactate dehydrogenase for cancer treatment. Expert opinion Compared with the conventional cancer treatment, specifically targeting the well-known Achilles heel, the Warburg effect has attracted considerable attention. Although there is still no single glycolytic agent for clinical cancer treatment, the combination of glycolytic inhibitor with conventional anticancer drugs or the combined use of multiple glycolytic inhibitors are being investigated extensively in recent years, which could emerge as attractive anticancer strategies.


YSe1.83 was synthesized by vapor transport technique and its crystal structure was determined. The structure was isostructure of LaTe2-x, which was layered structure consisting of two-atom thick layers of YSe with distorted NaCl-type structure and one-atom thick layer of Se. The substructure of YSe1.83 was tetragonal with space group of P4/nmm and a=4.011(2) and c=8.261(3) Å with final R/Rw=6.4/6.9 %. The superstructure with asuper=2a, bsuper=6b and csuper=2c was found. The measurements of electronic and magnetic properties of this compound indicate that it is an electronic insulator and diamagnet.


In this thesis, we develop a relational localisation theory for topological algebras, i.e., a theory that studies local approximations of a topological algebra's relational counterpart. In order to provide an appropriate framework for our considerations, we first introduce a general Galois theory between continuous functions and closed relations on an arbitrary topological space. Subsequently to this rather foundational discussion, we establish the desired localisation theory comprising the identification of suitable subsets, the description of local structures, and the retrieval of global information from local data. Among other results, we show that the restriction process with respect to a sufficiently large collection of local approximations of a Hausdorff topological algebra extends to a categorical equivalence between the topological quasivariety generated by the examined structure and the one generated by its localisation. Furthermore, we present methods for exploring topological algebras possessing certain operational compactness properties. Finally, we explain the developed concepts and obtained results in the particular context of three important classes of topological algebras by analysing the local structure of essentially unary topological algebras, topological lattices, and topological modules of compact Hausdorff topological rings.


Objective: Asthma is a chronic inflammatory disease caused by genetic and environmental factors. Skin tests show type 1 hypersensitivity reactions against various allergens. Allergic triggers and degree of sensitivity against a specific agent can be determined by skin tests. In this study; the skin test results in asthmatic children, the presence of allergic rhinitis based on family history, and evaluations depending on several factors have been considered. Material and Methods: Patients who had been diagnosed and monitored with asthma together with allergic rhinitis and had no any other disease were enrolled in to the study. A standard data form was completed for each patient. Pulmonary function tests were performed. Skin prick tests were also performed for each patient. Results were assessed depending on atopy in the family history and diagnostic groups of Asthma / Asthma and Allergic Rhinitis. Results: In this study, 236 asthmatic patients in total who were 6-18 years old were included: 155 (65.7%) were male and the mean age was 7.9 (7.4-12.2) (IQR) years. The number of asthmatic patients was 163 while the number of patients who had both asthma and allergic rhinitis was 73. The frequency of sensitivity to at least one allergen was 42.6 % according to the result of the skin test. The maximum sensitivity was for pollens with a rate of 23.6%. Atopy frequency according to the diagnostic groups was 39% in asthmatic patients and 52% in those with asthma and allergenic rhinitis (p=0.061). The allergen sensitivity was 39.8% in the group with a family history of atopy and 44.3% in the group without a family history of allergen sensitivity (p=0.496). Conclusion: Allergen sensitivity has an important role in asthma in childhood. Allergen sensitivity should therefore be investigated for all patients who are diagnosed as asthma. The socio-demographic characteristics and family history of each patient who has a skin test done should be carefully questioned in terms of other concomitant allergenic diseases. Our study is similar to other pollen sensitivity studies in general. As expected, the frequency of allergen sensitivity was higher in the group that had asthma together with allergenic rhinitis than those with asthma only. Allergen sensitivity was lower in our study for the group with a family history while it was expected to be higher.


According to database theory, a database designer can specify any set of data dependencies, no matter how complex, to constrain a database scheme. This paper investigates how much complexity is actually needed in real-world situations. It is shown that every "natural" set of mvd's must belong to a class of mvd's called conflict-free. Conflict-free sets of mvd's have the desirable property that they allow a unique 4NF dependency preserving database scheme; moreover, non conflict-free sets have no such normalization. If a set of mvd's is not conflict-free, then the dependencies are inadequately specified; there are semantic concepts that are unrepresented in the scheme. These concepts are isolated, and it is shown that adding these concepts amounts to making the set of mvd's conflict-free.


Genetically encoded sensors enable quantitative imaging of analytes in live cells. State-of-the-art sensors are commonly constructed by combining ligand-binding domains with one or more sensitized fluorescent protein (FP) domains. Sensors based on a single FP are susceptible to artifacts caused by differing expression levels or sensor distribution in vivo. Hence, our lab developed dual-FP Matryoshka technology introduced by a single cassette that contains a stable large Stokes shift (LSS) reference FP nested within a reporter FP (cpEGFP), allowing simple construction of intensiometric sensors with the capacity for ratiometric quantification. The first-generation Green-Orange (GO) Matryoshka cassette established proof of concept but required custom optical setups to maximize achievable dynamic range. Here, we present a genetically encoded calcium sensor that employs optimized second-generation Green-Apple (GA) Matryoshka technology that incorporates a newly designed red LSSmApple fluorophore. LSSmApple provides improved excitation spectrum overlap with cpEGFP, allowing for monochromatic co-excitation with blue light. The exceptionally large Stokes shift of LSSmApple results in improved emission spectrum separation from cpEGFP, which minimizes fluorophore bleed-through and facilitates imaging using standard dichroics and red fluorescent protein (RFP) emission filters. We developed an image analysis pipeline for yeast (Saccharomyces cerevisiae) timelapse imaging that utilizes LSSmApple to segment and track cells for high-throughput quantitative analysis. In summary, we engineered a new fluorescent protein, constructed a genetically encoded calcium indicator (GA-MatryoshCaMP6s), and performed calcium imaging in yeast as a demonstration.


A reciprocity counseling program had previously been used for adult marital problems and for child classroom problems. The present study extended the method to youth problems in the home and communitY with 29 vouths al!cd &16. including 12 teenagers. Tht: principal features of the components of the program were r~ciprocal behavior; I contracting. positive com· munication tra ining and self-correct ion. The number of problems reported by the parents and youths decreased by about 75> o after counseling vs little or no decrease for the wait-listed controls. The ratings of problem severity were also reduced and endured at the 6-month follow-up.


Purpose Passion is considered a critical aspect of entrepreneurship. According to the dualistic model of passion (DMP), entrepreneurs' passion for their work can be harmonious or obsessive, leading to different personal and work outcomes. Drawing on DMP and the self-determination theory, this paper investigates these two types of passion for work and their effects on entrepreneurs' subjective well-being (SWB), psychological strain and social loneliness.Design/methodology/approach The authors conducted a self-administered online survey with 312 entrepreneurs in Turkey. The authors selected the sample using purposive sampling and referrals through snowballing via associations, university start-up organizations, entrepreneur lists and personal networks. The data are analyzed using multiple regression analysis.Findings The results show that harmonious passion is negatively related to strain, while obsessive passion is positively related to both strain and social loneliness. Furthermore, both types of passion are associated with higher SWB. Finally, age moderates the relationship between obsessive passion and SWB.Practical implications The findings draw attention to another dark side to entrepreneurship and a useful perspective to raise awareness that entrepreneurs may think positively of obsessive passion and ignore the negative consequences.Originality/value This study contributes to the literature by showing that both positive and negative consequences of passion may co-exist based on the entrepreneurs' self-perceptions. It also contributes to the very scarce research in non-western, emerging contexts in entrepreneurial passion research and constitutes the first study conducted on this topic in Turkey.


This research was conducted to find out the gap value between student's actual perception and ideal expectations of the Dipa Makassar University website services quality which is measured by WebQual 4.0 Modifications quality dimensions; 1) Information Quality, 2) Service Interaction Quality, 3) User Interface Quality and 4) Usability. Data was collected using a questionnaire with simple random sampling technique. Furthermore, the collected data were analyzed using differences analysis and Importance Performance Analysis (IPA). The results of the study prove that there is a gap between students' perceptions and expectations on each website quality dimension, where the perceived value is smaller than the student's expectations. The smallest gap lies in the quality of service interactions with a conformity level of 87.56% which indicates that website services are quite successful in the quality of service interactions. The biggest gap lies in the quality of information with a conformity level of 68.80% which indicates that website services have not met student expectations, especially the quality of information.


Enterprise Resource Planning (ERP) systems have established a reputation in the world of business as indispensables tools that integrate all departments and functions across a company into a single computer system. However, implementing an ERP system does not always result in enhanced organizational performance. In order to ensure successful implementation, companies should study the critical factors having an impact on the whole procedure. In this context, the present study proceeds in developing and testing an original conceptual framework (research model), which explores the factors having an impact on ERP implementation success (internal environment, technology-related issues, implementation team, end-users), as well as the impact of the implementation itself on organisational performance. The proposed conceptual framework was tested, using a newly-developed structured questionnaire, in a sample of 204 Greek companies that have already implemented an ERP system. The Structural Equation Modelling (SEM) technique was used in order to test the research hypotheses.


Background The development of drugs that target lung adenocarcinoma caused by epidermal growth factor tyrosine kinase (EGFR-TK) and anaplastic lymphoma kinase (ALK) mutations has focused the need to obtain sufficient tissue at biopsy to allow the detection of such molecular markers and so improve treatment options for selected patients. To investigate this further, we looked at the diagnostic yield from various biopsy techniques in our large lung cancer unit (400 cases per year, overall histological yield 77.5%). Methods We collected data from all patients with an ultimate histological diagnosis of adenocarcinoma for the years 2014 to 2016, looking at the diagnostic method, whether tissue was analysed for molecular mutations, and whether repeat procedures were necessary for EGFR-TK and ALK testing. Results 224 patients were identified: 42 by EBUS-TBNA, 66 by CT-guided biopsy, 44 at bronchoscopy, 66 at surgical resection, 6 from pleural fluid, and 1 by lymph node FNA. For molecular testing see Table. In addition to those patients where sampling was insufficient to make the diagnosis, a further 30 had inadequate cell numbers for mutation analysis and the reporting pathologist recommended repeat procedures. Of the 10 patients who underwent this, only 2 were retested for molecular markers, and the Results were unchanged. Conclusion This study shows that all our pre-resection positive diagnostic samples for lung cancer do not always provide sufficient tissue for molecular analysis. Although insufficiency rates were similar between CT, EBUS and bronchoscopy, one third of CT-guided specimens had few cells for the definite exclusion of mutations. With the advent of new therapies for lung cancer, we need to optimise our diagnostic sampling techniques when testing for molecular mutations. Abstract P267 Table 1 Rate of insufficient tissue or inadequate cell number for molecular mutation detection per sampling technique Biopsy Technique Insufficient tissue for EGFR testing (% of biopsy samples per sampling technique) Insufficient tissue for ALK testing (% of biopsy samples per sampling technique) Inadequate cell number for definitive molecular mutation detection (% of samples per sampling technique) EBUS-TBNA 7.70% 12.80% 20% CT-Guided Biopsy 9.50% 20% 35% Bronchoscopy and biopsy 11% 11% 6.25% Surgical resection 0% 0% 0% Pleural fluid analysis 20% 20% 20% Lymph node FNA 0% 0% 0%


The mycoflora of stored rice was determined for 63 paddy grains samples and 32 polished rice samples collected from 18 counties of Zhejiang Province in 1980—1981. Forty eight species belonging to 17 genera of fungi were isolated and identified, including 5 species of Mucorales, 18 spp. of Aspergillus, 10 spp. of Penicillium, 4 spp. of Fusarium and other 11 species of Hyphomyeetes.
No notable differences could be found both in species and number of the mycoflora associated with the stored rice in different regions of the Province. When paddy grains were milled to polished rice, the kinds and numbers of fungi borne on the grains and percentage of infected kernels declined markedly. Samples from freshly harvested paddy grains showed the type of mycoflora composed of such field fungi as Alternaria, Curvularia, Cladosporium, Nigrospora etc.. When samples from paddy grains stored for one to four months were examined, it could be found that the total numbers of various kinds of fungi isolated from the grains and percentage of the infected kernels were at their maximum as a result of invasion by storage fungi. As to samples from paddy grains stored for one year or more, however, storage fungi predominated in mycoflora of the grains, and the total numbers of various kinds of fungi isolated and percentage of the infected kernels sharply declined. The examination showed that the kinds and numbers of fungi isolated from grains were similar between indica rice and japonica rice under similar conditions.


Alpha amylase is widely distributed in animals, plants and bacteria, and is one of the important digestive enzymes and has a significant effect on the growth of mollusk. It is the first time the alpha amylase gene in silver lipped pearl oyster Pinctada maxima is cloned. The full length of the cDNA(named as pmAMY) is consisted of 1732 bp, including a 5′ UTR of 25bp, an open reading frame(ORF) of 1554 bp encoding 518 amino acids and a 3′ UTR of 153bp. The estimated isoelectric point and molecular mass of deduced amino acid residues are 7.63 and 57.7 kD, respectively. Amino acid sequence analysis indicates that pmAMY contains a signal peptide with 16 aimino acid residues(MLLIVCSIAFFHSVYG), 8 cysteine residues(Cys46、Cys104、Cys157、Cys176、Cys392、Cys398、Cys464、Cys476), 3 active sites(Asp213、Glu249、Asp314), 4 calcium binding residues(Asn118、Arg174、Asp183、His217), 3 chloride binding sites(Arg211、Asn312、Arg350) and 4 conserved sequences(Ile111 Val116、Val207 Ala215、Phe247 Val251、Val308 Asn315). Blast analysis shows that pmAMY shares the highest identity(82%) with Pteria penguin, the lowest(27%) with Thermococcus hydrothermalis and 57% 79% with some other organisms.Two introns are obtained, being 846 bp and 162 bp, respectively. Both introns begin with GT and ended with AG, consistent with common sequences of intron splice sites. Tissue expression analysis indictes that pmAMY only exists in hepatopancreas.The results above lay a base work for further research on the function of pmAMY and discovery of SNPs as well as its relationship with growth trait of P. maxima.


This paper gives a comparative description of Synagelides agoriformis STRAND in BOSENBERG et STRAND, 1906, S. annae sp. n. from Japan and S. nishikawai sp. n. from Nepal.


Introduction: Respiratory Synctial Virus (RSV) is one of the most important viral pathogens for lower respiratory tract infections in children. RSV infections show seasonal pattern peaking during w...


We explore the basis and consequences of the formalism known in the literature as the method of local equilibrium. Contemporary controversies regarding the foundations of thermodynamics are rooted not only in different sets of concepts and principles, but also in semantics. An attempt is made here to use a consistent group of terms, each of whose dictionary meaning corresponds to its physical nature as closely as possible. Since the intention is to study irreversible processes in systems in which even locally there prevails a state of nonequilibrium, the term local equilibrium is abandoned in favor of the phrase principle of local state. In defining the thermodynamic state of system, a distinction is made between the intensive parameters which appear in the physical space and those which describe states of constrained equilibrium in the Gibbsian phase space. The principle of local state is applied by association with every nonequilibrium state n and accompanying equilibrium state e of equal values of U, a, {alpha}, and by asserting that the entropy {bar S} assignable in physical space and temperature {bar T} measured in it can be approximated by the values S and T calculated in the Gibbsian phase space by standard, classical methods. A continuous sequence of accompanying equilibrium states is called an accompanying reversible process, it is conceived as an adiabatic projection of the continuous sequence of nonequilibrium states. The essential part of the method consists in the formulation of the Gibbs equation for the accompanying reversible process in the phase space. It is noted that the local-state approximation, made explicit in this paper, has been used and tested in fluid mechanics though its validity is contested in contemporary continuum mechanics and mechanics of solids.


The Health Promoting Hospital (HPH) concept has gained much momentum since its development in Europe in the late nineteen eighties. The Montreal network of HPH was created in 2005, within the context of the last reform. The McGill University Health Center (MUHC) is a part of this network since 2007. This study focuses on the creation of a health promoting hospital setting for patients and addresses the mealtime experience of older hospitalized patients requiring a puree diet. A qualitative case study design was used to explore patients' perceptions of aspects of their puree meal tray, assistance provided by staff and the social context in which the meal was taken. Health professionals' view of the patients' experience were also obtained. Results indicate that the difficult identification of food items, flavour, appearance and variety were all important factors negatively affecting the mealtime experience. Feelings of loss of control were also reported by patients and staff. The social context in which the meal was taken was highlighted as an area which could be targeted to improve mealtimes. A program using formed puree food items could help lessen the negative impact of the prescription of a puree diet. Changes in nursing practices regarding the creation of a pleasant social atmosphere were identified as an inexpensive option to improve the mealtime experience for patients and decrease feelings of lack of control for staff in this aspect of care.


One of the main practical problems with dexterous robots is the complexity of integrating a large amount of sensors within a small robot architecture. In this paper, the control of cooperative robots without using velocity measurements is considered. Our main purpose is to analyze the feasibility of avoiding velocity measurements to manipulate an object firmly.


It is always attractive and challenging to explore the intricate behavior data and uncover people's motivations, preference and habits, which can greatly benefit many tasks including link prediction, item recommendation, etc. Traditional work usually studies people's behaviors without time information in a static or discrete manner, assuming the underlying factors stay invariant in a long period. However, we believe people's behaviors are dynamic, and the contributing factors including the social influence and personal preference for behaviors are varying continuously over time. Such continuous dynamics convey important knowledge about people's behavior patterns; ignoring them would lead to inaccurate models.

In this work, we address the continuous dynamic modeling of temporal behaviors. To model the fully continuous temporal dynamics of behaviors and the underlying factors, we propose the DP-Space, a dynamic preference probability space, which can capture their smooth variation in various shapes over time with flexible basis functions. Upon that we propose a generative dynamic behavior model, ConTyor, which considers the temporal item-adoption behaviors as joint effect of dynamic social influence and varying personal preference over continuous time. We also develop effective inference methods for ConTyor and present its applications.

We conduct a comprehensive experimental study using real-world datasets to evaluate the effectiveness of our model and the temporal modeling. Results verify that ConTyor outperforms existing state-of-the-art static and temporal models in behavior predictions. Moreover, in our detailed study on temporal modeling, we show that temporal modeling is superior to static approaches and modeling over continuous time is further better than that over discrete time. We also demonstrate that the ancient behavior data can still become important and beneficial if modeled well.


Objective
To investigate the value of ultrasonic two-dimensional speckle tracking imaging(2D-STI) layer-specific strain and transmural gradient in evaluating the changes of hypertensive patients′ left ventricular three layers myocardial function.

Methods
Thirty-five hypertensive patients without renal insufficiency were selected as group A, and 25 hypertensive patients with renal insufficiency as group B. For comparison, 40 healthy volunteers were gathered as control group. Then, the systolic peak longitudinal strain of the left ventricle(LPS), endocardium(LPSEndo), mid-cardium(LPSMid) and epicardium(LPSEpi) were collected.After that, features of transmural gradient(ΔLS) and its percentage(ΔLS%) were analyzed.

Results
For each group, gradient features exist in each layer of left ventricular myocardium: LPSEndo>LPSMid>LPSEpi. For each group, the differences between LPSEndo and LPSMid, and that between LPSEndo and LPSEpi were both statistically significant(P 0.05). Compared with control group, the ΔLS%Endo-Mid of group A rised, and the ΔLS%Endo-Mid, ΔLS%Mid-Epi of group B rised, the differences were statistically siginificant(all P<0.05). Compared with group A, the ΔLS%Endo-Mid, ΔLS%Mid-Epi of group B rised, the differences were statistically siginificant(all P<0.05).

Conclusions
The layer-specific strain technique can quantitatively evaluate the changes of systolic function of the left ventricular myocardium in hypertensive patients. ΔLS% may have better sensitivity than ΔLS in dection of systolic function damage of the left ventricular myocardium and can provide more reference for the evaluation of left ventricular systolic function.

Key words:
Echocardiography; Hypertension; Ventricular function, left; Layer-specific strain; Transmural gradient


Benefits that customers derive from their participation to relationship programs are not only economic, or even utilitarian (e.g., convenience). In this article, we shed some light on the variety of perceived benefits – utilitarian, hedonic and symbolic – that customers may retreive as members of these programs, based on a literature review in various fields (e.g., consumer value theory, shopping motives theory, use and gratification theory...), and a qualitative study. We then propose and validate a scale to measure five types of perceived benefits, and apply our generic measurement tool to the retailing industry in France. We identify the main benefits that lead to a higher satisfaction level toward the programs. Finally, we demonstrate the relevance of the concept of perceived benefits as a segmentation criteria, and its potential to improve the efficiency of relationship programs, thanks to a better understanding of customers' perceptions.


Stacia M. Stribling, Ph.D., is an Assistant Professor at George Mason University in Fairfax, VA. As an advocate for teacher research in public schools, Stacia is active in the Teacher as Researcher SIG of AERA and serves on the NAEYC Teacher Research Steering Committee. T here is an old adage that the best way to learn something is to teach it. If "learning" is a state of more deeply understanding an issue or a concept, then I would agree with this maxim as it relates to my knowledge of quality and ethics in teacher research. While I have wrestled with issues of quality and ethics as a teacher researcher, only after encountering numerous challenges while instructing others in teacher research methods have I begun to better understand the ways in which they intersect and impact the entire research process. Determining how to respond to the experiences and issues my graduate students faced in their schools as they began to undertake teacher research forced me to define more clearly where I stand on these matters.


Two experiments were conducted to assess the effect of three poultry diets on growth and reproductive performance of Achatina achatina snails. In the first experiment 120 juvenile snails in groups of ten were fed four experimental diets for a period of 182 days. The treatments were T1-Broiler starter, T2 -Grower mash, T3 -Layer mash and T4 Unripe pawpaw fruits. The Completely Randomised Design was used with four treatments and each replicated three times. The second experiment involved 120 adult snails fed the four diets using the same experimental design. The results revealed that juvenile snails fed on broiler starter diet (T1) had significantly (P 0.05) in terms of feed intake, final weight, weight gain and feed conversion ratio. Feed intake seemed to follow a trend in the adult snails; feed intake increased as protein content of feed increased. No significant differences (P>0.05) were observed in the adult snails in terms of total eggs laid and egg length; however, egg weight and egg width were found to be significantly higher (P<0.05) for snails fed layer mash (T3). Therefore, the broiler starter (T1) could be fed to growing snails to improve performance whereas the layer mash (T3) could be fed to enhance reproductive performance in Achatina achatina.


It has become commonplace to portray Nietzsche äs the preeminent philosopher of nihilism. This reading, however, is highly questionable, since the term 'nihilism' does not appear in his notes until 1880 or in his published work until 1886. In fact, nihilism is only one in a series of concepts that Nietzsche employed in his attempt to come to terms with the Spiritual crisis of European civilization. Moreover, he used it only briefly and then abandoned it in favor of the concept of decadence. Nihilism for Nietzsche grew out of the death of God. God, äs Nietzsche's Zarathustra argues, died out of pity for man, i. e., because man was no longer powerful enough to sustain him. The death of God is thus the reflection of a fundamental degeneration of humanity. Man is no longer capable of creating or sustaining gods. As Nietzsche remarks in The Antichrist^ *!AJmost two thousand years — and not a single new god!" The death of God, however, opens up new possibilities, freeing man in a way unknown since the tragic age of the Greeks. According to Nietzsche, we can now become more than we have been or less, rising to glorious new heights or sliding into dark depths. In his late thought, he associates the ascending path with Dionysus and the descending path with the Crucified. The future of humanity, in his view, rests upon our decision for one or the other of these two possibilities. The contrast could hardly be more stark — choosing the Dionysian path is saying Yes to life in all of its terrifying chaos and complexity; choosing the path of the Crucified ^is rejecring life in favor of an imaginary beyond. It is within this formulation of these two possibilities that Nietzsche deploys the concept of nihilism.


Objective To study the effect of theanine on the fatigue.Methods After the mice were administered for 30 days,the swimming test were carried out,and the death time was observed and recorded;after mice swimmed for a period,the blood were taken for determinig urea nitrogen in serum and lactic acid in blood;The liver were taken for determinig the glycogen.Results Theanine prolonged significanty the time of mice swimming,decreased the consumption of glycogen and the level of urea nitrogen in serum;Also theanine inhibited the augment of lactic acid in blood caused by swimming,and accelerated the elimination of the increased lactive acid in blood.Conclusion Theanine could have the action of anti fatigue.


The most important factor that affects the testimony of witnesses in the court is the defects existing in the legislation of the criminal testimonial system.From the angle of jurisprudence,inconsistence of legal systems,imperfection of legal adjustment mechanism and lack of scientific legislative techniques are the main problems.These problems should be solved in the course of re-amending the Criminal Procedural Act so as to enable a witness to give his voluntary testimony.


Received: 4 July 2019 Accepted: 26 September 2019 The ability of the non-uniform Fast Fourier Transform (NUFFT) to predict the particle feedback on the flow in particle-laden flows in the two-way coupling regime is examined. In this regime, the particle back-reaction on the fluid phase can substantially modify the flow statistics across all the scales, when particle loading is significant. While many works in the literature focus on the direct B-spline interpolation, which is now a well-established method for the one-way coupling, only a few methods are available for the computation of particle back-reaction, which are often lower order and reduce the overall accuracy of the simulation. In our implementation, particle momentum and temperature back-reactions on the fluid flow are computed by means of the forward NUFFT with B-spline basis, while the B-spline interpolation is performed as a backward NUFFT. An application of the NUFFT to the simulation of a statistically steady and isotropic turbulent flow, laden with inertial particles is presented. The effect of particle feedback on velocity and temperature structure functions and on particle clustering is discussed as a function of the Stokes number, together with the spectral characterization of the particle phase.


The attitudes and behaviors of healthcare service providers can influence both provider and patient satisfaction. Groups of individuals that communicate effectively, delegate tasks, share responsibility, and work towards a common goal are indicative of a collaborative clinical culture. Using a new survey instrument, we were able to assess the level of collaborative clinical culture in the Department of Anesthesiology and Perioperative Care at the University of California, Irvine. Positive team function was found to be associated with high levels of morale, and team problems were associated with increased job stress. The survey instrument was shown to have excellent internal consistency, and is suitable for measuring collaborative clinical culture in this type of hospital setting. This exploratory analysis with a new instrument provides a baseline from which additional research in multiple departments and with multiple patient outcomes can be performed.


As 'Scandinavian cinema' is the subject both of cinema studies and Scandinavian studies, this article discusses their relationship in the past and present. The primary focus is on their differing approaches as well as possible synergies between these two disciplines with regard to the study of Scandinavian cinema. Scandinavian studies is a necessary supplement and a support to cinema studies, while engaging with cinema is at the same time both an opportunity to take the transition to Scandinavian studies as Kulturwissenschaft seriously and to attract students interested in media.


Soft-output equalizers that exploit a priori information on the channel inputs play a central role in turbo equalization. Such equalizers are traditionally implemented with the forward-backward or BCJR algorithm, whose complexity is prohibitive for channels with large memory. Many reduced-complexity alternatives to the BCJR algorithm have been proposed that use a linear equalizer and use the a priori information to perform soft intersymbol interference cancellation. In this work, we propose a soft-feedback equalizer (SFE) that combines the equalizer output and the a priori information to improve interference cancellation. Also, by assuming a statistical model for the a priori information and the SFE output, we obtain an equalizer with linear complexity, as opposed to the quadratic complexity of some similar structures. Simulation results show that the SFE may perform within 1 dB of a system based on an BCJR equalizer, within 0.3 dB of quadratic complexity schemes, and consistently outperforms other linear complexity schemes.


Each of the mobile payment device are associated with a single account in a payment processing system is distinguished by using the track data. Track data from the mobile payment device is read at a plurality of merchant point of sale (POS) terminals, respectively. Rather than relying on a PAN, the merchant can use the data track, or a proxy as the unique identifier for the mobile payment device. Traders and on the basis of the unique identifier may be carried out commerce related to mobile payment device. For example, shipping charges for each occupant gatjiman account of in the transportation environment having a different mobile payment device is to be calculated using the unique identifier, such as the full track data read from both the two tracks of the mobile payment device to the can. Card account, GUID


Resonance demodulation is a commonly used method to obtain fault information, whose main challenge is to seek a suitable frequency band for demodulation. Autogram is a recently proposed method for optimal demodulation frequency band (ODFB) selection, in which the frequency domain is divided by a binary tree structure. However, the frequency band information obtained by Autogram is easily missed. To solve this issue, a 1/3 binary tree structure is employed to segment the frequency domain and improve the segmentation accuracy of Autogram. Despite this, the frequency bands with different position information cannot be fully obtained through the above-mentioned structure yet. In this article, the traverse symplectic correlation-gram (TSCgram) is proposed to overcome the shortcomings existing in Autogram and based on that, a novel fault diagnosis method for rolling bearing is proposed. First, the frequency domain of the raw vibration signal of rolling bearing is accurately divided through the traversal segmentation structure. Then, the concept of symplectic correlation is introduced to reduce the interference of noise, as well as other unrelated components on the traditional kurtosis, thus further improving the accuracy of ODFB detection. Finally, the band position corresponding to the maximum symplectic correlation kurtosis (SCK) value is chosen as the ODFB for fault diagnostics of rolling bearing. Also, the proposed method is applied to the simulated and measured data analysis by comparing it with fast kurtogram and Autogram methods. The comparison and analysis results indicate that the fault diagnostic effect of the proposed TSCgram method is better than the comparing methods.


In this paper, in order to reduce power dissipation at MOSFET gate port of class E amplifier, we propose gate signal peaking using third harmonic component. With PSPICE simulation, it is shown that higher power efficiency and higher output power of power stage can be obtained using third harmonic component than pure sinusoidal gate signal with same level of gate power dissipation.


User services at NlU (Acadenzic Compzdting Senlices) faces the sanze trezzds that menace and excite euery other i?zformation services organization. We shozrld not fool ozzrselzles that tlzese trends represezzt a single transition, and tlzaf we will lzot need to meet these clzallenges again. Dyer associates chatzge COT lack of it) witlz organixtional culture. Hozu do we recognize inter?zal and external clrltllre and anticipate change? Some of these changes were hrozcght on becazise of the inability to get responsizle seruicefrom the conzpzlter center. Sonze of these charzges were brouglzt on by new azzd inexpensiz7e technology. To change, to lzandle change, azzd tojtnction effectizlely, Dmcker suggests that we define "what ozlr business is and what it shoztld be". Do we knozu what semice is? User services is at tlze in&face betzueen the cliefz t and tlze conzpzcter center. There are activities tlzat wefoczls on that we believe will nzake ourselves better. Deming szcggesls that qztality is a focus on client expectations, worker parficipation, and constant improvement. How do tlze ideas apply to zlser seruices? The role of ztser services is to develop and provide information abozlt information processing. This reqzzires technically conzpetent workers-knowledge zuorkers. Drzrcker szcggests that the knowledge zuorker direct himselfor keyself. Wlzat are the responsibilities of the knozuledge zuorker? User services and tlzeir environnzent are chalalzging. It is important to z4nderstand client expectations and to empower workers to nzeet tlzose expectations to sz4miue. Drzrcker szcggests that the manager has responsibilities to the orgalzizatiolz tlzat allozu workers to be eflective and clients to be satisfied. Meeting these responsibilities reqzzires collaboration and consensus and no longer includes the use of power and authority. What is the role of the manager? Recognizing Culture and Anticipating


The present invention is a technique related to a method for producing an organic thin film transistor by applying, and a method of manufacturing the composite thin film manufacturing method of the compound semiconductor thin film of an organic / polymer. In the present invention, using a corona discharge causes the organic semiconductors and polymeric vertical phase separation, to jimyeo a desirable crystal growth of the organic semiconductor made in this process, the growth surface of the thin film uniformly increase the device performance as a semiconductor layer of the organic thin film transistor can. Representative examples of the organic semiconductor TIPS-PEN, oligo thiophene, etc. can be used.


In this study, we tried to analyze the influence of ICM(Iodinated Contrast Media) in MR imaging compare to GBCA(Gadolinium Based Contrast Agent), and as this result we discussed whether resonable or not the protocol which is MRI scan after enhanced CT scan without proper time interval in clinical field. For this research, we assembled two phantoms. which one was iodine and another one was gadolinium. We did test two phantoms in conventional MRI scan which is T1, T2, T2 FLAIR and 3D angio. After that, quantitative analysis was progressed. The results of study were as follow : SSI(Saline's


Basic education reform proposed new reqnest to physics education and teacher's traiming.Zn this paper,we discuss the classroom teaching mode of physics teaching method.


This paper describes a fault tolerant controller (FTC) design to enhance the wind energy conversion system (WECS) with Permanent Magnet Synchronous Generator (PMSG) robustness to mechanical rotor speed sensor failure. This proposed sensor FTC strategy is based on the combination of the actual sensor and an adaptive Luenberger observer with a decision-making unit, which detects whether the mechanical sensor is faulty and selects the most accurate generator rotor speed and position for the Indirect Field Oriented control (IFOC) loops. Extensive simulation study shows that the proposed sensor FTC approach can efficiently detect the generator speed sensor fault and tolerate this type of fault, and so offers a simple configuration with a satisfactory accurate reference-rotor-speed tracking requirement for maximum power extraction.


Germanes, R3GeH (R = Me, Et, or Cl) react with (Ph3P)2Ir(CO)CI to form six-co-ordinate dihydrido-complexes, (Ph3P)2Ir(CO)(H)2GeR3(IV); their stereochemistry in solution has been elucidated from their 1H n.m.r. and i.r. spectra. Triphenylgermane behaves differently forming the five-co-ordinate complex, Ph3PIr(CO)(H)(CI)-GePh3(XII). The Ge–Ir bond in (IV)(R = Me or Et) is cleaved at 150° with regeneration of the germane. It is also cleaved by oxygen, C2H4Br2, I2, and HCI, H2, and HgCl2. Triphenylphosphine in (IV) may be replaced by Et3P or (Ph2PCH2)2. Ethylene is hydrogenated by (IV) to yield the iridium(I) complex, (Ph3P)2Ir(CO)GeR3(XI) which is reconverted into (IV) by H2. Trimethylgermane and (Et3P)2Ir(CO)CI form H2, Me6Ge2, and (Et3P)2Ir(CO)(H)2CI. Bistrimethylgermylmercury and (Ph3P)2Ir(CO)CI react to give the germylmercury complex (Ph3P)2Ir(CO)·Hg·GeMe3 together with mercury and trimethylchlorogermane.


The aim of the examination of the passion altarpiece conserved at the Mayer van den Bergh museum at Antwerp was to study the original polychrome painting. Recent layers of paint were removed after repeated softenings with benzol, methylene and ethylglycol chlorure, and sepiolite. The original paint was protected with wax and polyvinylacetate.


A sample of 1,276 male stipendiary parochial clergy working in the Church of England completed the Revised Ministerial Job Satisfaction Scale and an index of charismatic involvement, together with the short-form Revised Eysenck Personality Questionnaire. After controlling for age and personality, charismatic clergy record higher levels of job satisfaction in comparison with clergy not influenced by the charismatic movement.


Vitrification combined with in-straw dilution may replace conventional cryopreservation of bovine embryos, but this requires further study for practicality. Our objectives were to compare three ethylene glycol concentrations (6, 7, and 8 M) and two equilibration times (2.5 and 3.5 min) for one-step addition of cryoprotectant. In vitro-matured oocytes from slaughterhouse ovaries, fertilized using sperm of 3 bulls, were cultured in chemically defined medium (CDM-1/CDM-2) plus FAF-BSA to produce 420 blastocysts. Day 7.5 embryos were placed into HCDM-2 (HEPES-buffered medium) and then transferred to a 6 μL drop of vitrification solution (V) (6, 7, or 8 M ethylene glycol, 0.5 M galactose, and 18% w/v Ficoll 70 in HCDM-2). Immediately thereafter, 1 cm column of DHCDM (0.5 M galactose in HCDM-2) was drawn into a 0.25 mL straw, followed by a 0.5 cm column of air and another 7 cm of DHCDM. Another 0.5 cm column of air was aspirated before the 6 μL of V (0.5 cm) containing the embryos were aspirated; then 0.5 cm of air followed. Finally, DHCDM was drawn until the first column came into contact with the cotton plug. Straws were then heat-sealed and plunged into liquid nitrogen slightly above the embryos after 2.5 or 3.5 min equilibration. The rest of the straw was then submerged slowly. Straws were thawed in air for 10 s and then in 37°C water for 20 s. Straws were held at room temperature (24°C) for 4 min before being expelled into HCDM-2. They were then placed into CDM-2 + 5% FCS for culture. Quality score (1 = excellent, 2 = fair, 3 = poor), survival (S) as determined by expansion of blastocysts, and hatching (H) were assessed at 24 and 48 h post-thaw. Data from 6 replicates (2/bull) were analyzed by ANOVA after arc sin transformation of percentage data. S and H responses were calculated as a percentage of non-frozen controls in the same replicate. Control survival and hatching rates were: 24S: 90%, 24H: 50%, 48S: 90%, 48H: 72%. Quality scores at both 24 and 48 h were higher (P   0.1). Neither ethylene glycol concentration nor exposure time affected survival or hatching at 24 or 48 h (P > 0.1). Survival rates (as a % of control) at 48 h were: 8 M: 57%, 7 M: 55%, 6 M: 36% and hatching: 8 M: 39%, 7 M: 30%, and 6 M: 21%; 2.5 min tended to be better than 3.5 min for survival at 24 h, hatching at 24 h, survival at 48 h, but not hatching at 48 h (56% and 43%, 30% and 26%, 55% and 44%, 28% and 32% respectively). Higher concentrations of ethylene glycol proved beneficial in terms of embryo quality, with the same trend for survival and hatching rates. One-step addition of cryoprotectant for vitrification shows potential for simplifying embryo cryopreservation. However, further research is needed to produce more acceptable survival rates and to study vitrification of in vivo-produced embryos.


Extract: A 28-month-old Negro male with atypical Sandhoff's disease (GM2 gangliosidosis, type 2) is described. Clinical presentation closely resembled Sandhoff's disease. The appendiceal neuron cytoplasm was distended with periodic acid-Schiff (PAS)-positive material. Hepatic glycolipid N-acetylneuraminic acid was elevated 1.5-fold, chiefly because of increased GM2. Neutral glycolipid hexose was elevated twofold, mainly because of a component with globoside-like chromatographic properties. Unlike patients with Sandhoff's disease, the child had total β-D-N-acetylhexosaminidase activity 20–24% of normal in serum and plasma and 7–11% of normal in leukocytes and cultured fibroblasts, but activity in liver (<2% of normal) was similar to that in Sandhoff's disease. In all tissues examined, >95% of the activity was heat denaturable, corresponding in electrophoretic mobility to the heat-denaturable component of normal tissues. The decrease in heat-denaturable activity with time and the pH optimum were similar in patient and control crude tissue preparations and partially purified preparations of plasma hexosaminidase A. In the child's mother, total hexosaminidase activity was approximately 50% of mean control values in serum, plasma, and leukocytes, and serum hexosaminidase A was relatively increased. This finding, together with the death of at least three other children in the kindred from an apparently phenotypically similar illness, indicates the inherited nature of the disorder.Speculation: Appreciable hexosaminidase activity in serum and plasma and its marked deficiency in liver suggest that the active form (or forms) in serum and plasma differ from those in solid tissues, and that the mutation in the case described has altered the hexosaminidases in a manner that virtually abolishes their activity in solid tissues but permits their partial activity in serum and plasma.


Name of Sponsor /Company: Individual Study (For National L7CB S.A. Pharma Sector Table Referring to Authority Use Part IV Only) Of the Dossier Name of Finished Product: Volume: Zyrtec@ Name of Active Ingredient: Page : Cetirizine dihydrochloride Title of Study: EARLY TREATMENT OF THE ~TOPIC ~HILD (E.T.A.C.@) EVALUA=ION OF THE EFFICACY AND SAFETY OF CETIRIZINE IN PREVENTING THE ONSET OF ASTHMA IN CHILDREN WHO SUFFER FROM ATOPIC DERMATITIS. A MULTI-COUNTRY, DOUBLE BLIND, W4.N'DOMISED, PLACEBO-CONTROLLED TRIAL . Investigators: The E.T.A.C.@ Study Group Composition of the Scientific Advisory Board: J.O. Warner (Southampton,GB), Chairman L. Businco (Roma, I) K. Knol (Groningen,NL) .0. Casimir (Bruxelles,B) J.L. Menardo (Montpellier,F) I'.L. Diepgen (Erlangen,D) C. Naspitz (S~o Paulo,BR) M. Kjellman (Link@ping,S) U. Wahn (Berlin,D) Publication (reference)' – Oranje A.P., Staider J.F., Taieb A., and de Longueville MScoring of atopic dermatitis by SCORAD using training atlas by investigators from different disciplines. Pediatr Allergy Immunol 1997;8:28-34. — ETACTM Study Group. Determinant of total and specific IgE in infants with atopic dermatitis. Pediatr Allergy Immunol 1997;8:177-84.


Volatile chemicals in the headspace above heated pork fat were purged into aqueous solutions of cysteamine, sodium bisulfite, or methylhydrazine to trap aldehydes and ketones. Nine aldehydes and four ketones were determined as thiazolidine derivatives in traps containing aqueous cysteamine or aqueous sodium bisulfite. The major compounds produced were hexanal, heptanal, and pentanal. In general, aqueous cysteamine was more efficient at trapping carbonyl compounds than was aqueous sodium bisulfite. However, formalydehyde and acetaldehyde were trapped better by sodium bisulfite solution than by cysteamine solution. Acrolein and malonaldehyde were determined as l-methyl-2-pyrazoline and 1-methylpyrazole, respectively, from the trap containing methylhydrazine. This represents the first time that malonaldehyde has been determined in the vapor phase.


The purpose of the criteria presented here is to provide standard guidance for the design of nuclear radiation shields thoughout new facilities. These criteria are required to assure a consistent and integrated design that can be operated safely and economically within the DOE standards. The scope of this report is confined to the consideration of radiation shielding for contained sources. The whole body dose limit established by the DOE applies to all doses which are generally distributed throughout the trunk of the body. Therefore, where the whole body is the critical organ for an internally deposited radionuclide, the whole body dose limit applies to the sum of doses received must assure control of the concentration of radionuclides in the building atmosphere and thereby limit the dose from internal sources.


The problems related to the synthesis of automation systems of driving tractor units in forest nurseries that provide performance without human intervention throughout the sequence of operations of tree planting material growing are examined


Scientific justification of necessity of carrying out certification of deposits and opencasts for production the all-widespread minerals is given in article. As an example we made the passport for Streletskiy chalk deposit in Belgorod region of Belgorod oblast.


Radiative relaxation times of optical states in small dielectric particles of arbitrary shape are calculated in the quasistatic limit up to the second order of perturbation theory, assuming that the polarization distribution for the optical states is known. The concept of antisymmetrical optical states, previously developed for a system of discrete dipoles, is generalized for the case of a bulk dielectric particle. We use the integral form of Maxwell's equations to obtain a general expansion of solutions for the polarization function inside a particle in terms of eigenfunctions of the integral interaction operator. Then we calculate imaginary parts of corresponding eigenvalues, which determine the radiative relaxation times of optical excitations, treating the non-Hermitian part of the interaction operator as a perturbation. The imaginary parts of eigenvalues are expanded in terms of total multipole momenta of corresponding eigenmodes. Particles with special properties of symmetry can possess polarization modes with very large radiative relaxation time. We also discuss a possibility of application of the eigenfunction decomposition to numerical calculations of optical cross-sections for some particles of non-spherical shape.