Background Immune check point inhibitors (ICPis) have transformed the treatment landscape for several cancers, but at the cost of triggering ICPi-induced colitis which resembles some aspects of IBD. Diagnosis is often made by symptoms, or by identifying endoscopic features of colitis. Little is known about histological findings in the absence of macroscopic disease. Furthermore, first-line management strategies beyond the use of systemic corticosteroids have not been explored. Our aim was to assess the incidence of microscopic inflammation in patients with ICPi-diarrhoea, and report our experience of treating two such patients with beclomethasone diproprionate (Clipper). Methods Electronic records of patients with advanced melanoma and ICPi- diarrhoea/colitis at the Royal Marsden Hospital (RMH) and Guy's and St Thomas' Hospital (GSTT) between 2011–2016, were retrospectively reviewed. Endoscopic, histological and clinical outcome data was recorded for patients who underwent flexible sigmoidoscopy and had colonic biopsies taken regardless of macroscopic findings. Two symptomatic patients (one treated with anti-PD-1, and another on combination -anti-PD-1/anti-CTLA-4 therapy) with isolated microscopic disease were managed with 5 mg Clipper, once a day, for 4 weeks. Endoscopic, histological and clinical outcomes were recorded 6 weeks after completion of therapy. Results A total of 63 flexible sigmoidoscopies were performed in 59 patients with ICPi diarrhoea/colitis. Microscopic inflammation with normal macroscopic appearances were recorded in 22% of cases. 6 patients were prescribed anti-CTLA-4, 4 anti-PD-1, and 4 combination therapy. Histological features that were distinct from conventional microscopic colitis were recorded in the majority of patients (10/14), which included acute and chronic inflammation, architectural distortion, crypt abscess formation and neutrophil infiltration. Four patients had changes consistent with conventional microscopic colitis (2 lymphocytic colitis, 2 collagenous colitis). Clipper induced clinical remission within 7 days, and histological remission by week 6 in both patients with ICPi-induced microscopic inflammation. There was no treatment associated adverse events. Conclusion Microscopic inflammation in the absence of macroscopic features of colitis is a common finding in ICPi-induced diarrhoea, justifying the routine practice of performing colonic biopsies even when endoscopy is normal. Our favourable clinical experience of using Clipper in 2 patients with microscopic inflammation merit further investigation in appropriately controlled clinical trials.


(Received 24 January 2013; published 8 July 2013)Usingqualitativeconsiderationsbasedonatwo-centerapproximationfortight-binding-modelmatrixelements,we demonstrate that Rashba interactions in complex-oxide two-dimensional electron gases are due primarily tochanges in metal-oxygen-metal bond angles at surfaces and interfaces. We verify this conclusion by comparingour picture with illustrative


The resume of theses. Methodological instructions are lied in the basis of algorithm[6]. The algorithm is based on different influence of lithology on TNNL,GGL,AL.methods and let to divide carbonate rocks to limestones, dolomites and dolomitzed limestones and to point reservoir properties of the rocks.
The main distinction of this method is that from rhe beginging you should point the lithological identity of the rocks and after this you should do the calculation of porosity and also the refuse of introduction of amendments for clay content.This is achived by using of main parameters, calculated for real composition of the rocks (mixture of limestone -dolomite)


model of self-regulation, the Centre supports calls for a number of changes in the current system to shore up its integrity and ensure that adequate investor protections are in place. In particular, we believe that guidelines for establishing an effective system must address public participation, continued flexibility, transparency and accountability, the development of effective surveillance, supervision and enforcement powers, and a board that follows an open election process that takes into account all stakeholders, not just SRO members. We also recognize the additional conflicts that this system faces as exchanges "demutualize" and become for-profit entities while continuing to regulate their members and markets. To address this, we support the establishment of an independent SRO body to oversee the regulation of the securities market with the various exchanges assuming continued responsibility for market operations. In this era of global consolidations, we also recognize the growing need to engage in cooperative efforts to regulate across borders. While there is no one regulatory model for securities regulation on a global basis, there are a number of areas in which most securities regulators share concern, regardless of the country, market, or type of regulation (selfregulation or government imposed) practiced. The International Organization of Securities Commissions (IOSCO), of which CFA Institute is an affiliate member, has already issued 30 Principles of Securities Regulation. Drawing on these principles, we urge renewed attention to the "commonalities" of regulation shared by the increasing global marketplace. In the wake of continued consolidations and uncertainty about the particular standards that will apply, we believe that industry participants and investors lack a uniform way to assess the risk associated with investing. We therefore recommend that that the major markets worldwide designate a global regulator or "overseer" to rate compliance with a set of commonly recognized standards.


A dynamic parameter estimation method with a two step algorithm has been developed based on spectral analysis. The spectral density function is first obtained from input-output signals of a system, then the dynamic parameters can be estimated from frequency response data. Some parameter estimation algorithms are derived by minimizing a unified loss function with different weight selections. Some excellent application results have been achieved in the measurement, simulation, compensation and control of sensors, actuators and precision machineries.<<ETX>>


A molded shell member includes an upper plate (1), surrounding side wall (2) and the lower plate (3), the upper plate (1), surrounding side wall (2) and the lower plate (3) enclose a hollow cavity, characterized in that the upper plate (1), surrounding side wall (2) or the lower plate (3) at least a base layer laminated with at least one laminated layer (4), laminated layer (4) and the base layer laminated synthetic whole, at least one surrounding side wall is provided on the hollow body (2) has at least one lateral groove (5) is provided with a connecting member between the hollow body connected to one another on the hollow body (19), the lower plate (3) extending there the pick side (21), at least two of the hollow body is connected by picking side (21) into a mold composed of a group within the cavity between the ribs shell member, the hollow body (20). Suitable for in-situ reinforced concrete or prestressed reinforced concrete hollow floor, roof, walls, foundation slab and hollow bridges, especially for hollow floor without beam use.


BACKGROUND
Dietary L-leucine or its metabolite 𝛽-hydroxy-𝛽-methylbutyrate (HMB) has a crucial role in the muscle protein metabolism of broilers during the first few-week growing period. This study aimed to evaluate the effects of L-leucine (LLPD) or HMB (HLPD) supplementation in a low-protein diet (20%, LPD) until 21 days old on performance, carcass weight, muscle yield, and meat quality, as well as intestinal morphometry in broiler chickens.

RESULTS
From d 1 to 42, LPD decreased body weight gain (BWG) and feed intake (FI) and increased feed conversion ratio (FCR) compared to a standard protein diet (22%, SPD). The LLPD and HLPD did not affect FI, but the LLPD decreased the BWG and increased the FCR compared to the SPD. The LPD group had lower body and muscle weights than other groups. Compared to LPD, HLPD increased dressing percentage. The LPD decreased the serum IGF-1 content compared to the SPD and LLPD. The duodenal villus height of the LPD and LLPD broilers was smaller than those of the SPD and HLPD birds. The HLPD broilers had lower duodenal villus width than the SPD birds. The duodenal crypt depth and ileal mucosal thickness were higher in the HLPD group than in other groups. The HLPD and LLPD enhanced the ileal villus height compared to the SPD. The LLPD and HLPD treatments did not affect meat quality traits compared to the SPD treatment.

CONCLUSION
Dietary HMB could be a conducive approach to reducing dietary protein for broilers until 21 days old. This article is protected by copyright. All rights reserved.


Huisache [Acacia farnesiana (L.) Willd. # ACAFA] and Mexican palo-verde (Parkinsonia aculeata L. # PAKAC) are native woody legumes that often occur together on rangelands of southern Texas and northern Mexico. Huisache produces a profusion of orange-yellow flowers during February or March giving it a conspicuous golden appearance. Mexican palo-verde produces a heavy bloom of yellow flowers in mid-April or early May giving it a yellow-green coloration. Plant canopy light reflectance measurements of flowering huisache showed that its reflectance at the 0.55- and 0.65-μm visible wavelengths was significantly higher than that of Mexican palo-verde in the vegetative stage and four other associated plant species or mixture of species. Conversely, reflectance measurements of flowering Mexican palo-verde showed that its reflectance at the 0.55-μm visible wavelength was significantly higher than that of huisache in the vegetative stage and the same four associated plant species or mixtures of species. Flowering huisache had a golden color on conventional color (0.40-to 0.70-μm) aerial photos that made it distinguishable from other plant species, whereas flowering Mexican palo-verde had a pink image on color-infrared (0.50- to 0.90-μm) aerial photos. However, immature plants of both species cannot be detected using this technique. Computer-based image analyses of conventional color film positive transparencies showed that huisache infestations could be quantified from associated rangeland species. This technique can permit 'percent land area infested' estimates of mature huisache on rangelands. These results show that aerial photography may be a useful tool to detect and monitor the spread of huisache and Mexican palo-verde on rangelands, and to delineate areas needing control.


The present invention discloses a kind of slip control method and a terminal belonging to the touch area. The method comprising: displaying the current touch point comprises slidable track; detecting a triggering signal acting on said sliding track; if the trigger signal is detected is re-determined according to the trigger signal of the current touch control point; according to the current touch point on the sliding track can be re-determined corresponding first track to a second track change; wherein the said first track is a sliding track on all or part of the track, the the length of said second track is greater than the length of the track. By the present invention, after detection of the trigger signal, the slidable track corresponding to the track of changes to a second longer track length, to provide a longer, larger and wider space to a user operation so that the user can quickly slip control operation is completed, saving battery power, the effect of the increase of life of the terminal.


Background: Current evidence supports telehealth as a promising approach to increasing access to care and improving patient outcomes. However, provider and patient perspectives on telehealth can influence engagement with interventions and may impact health behavior and clinical outcomes for better or worse. Prior studies have focused mainly on the views of healthcare providers (HCPs). More research is needed on patients' perspectives in order to better understand how their perceptions influence use of telehealth, subsequent health behaviors, and clinical outcomes. Therefore the purpose of this study was to explore patients' experiences, perspectives, and attitudes related to telehealth. The theoretical framework guiding this research posits that patient adherence to self-care activities is influenced by patient perceptions about participation in the healthcare encounter, self-efficacy, and understanding of healthcare provider recommendations. Telehealth interventions may reinforce these factors, thereby supporting improved adherence to self-care regimens and improved clinical outcomes. Methods: Data for this study were collected from 16 attention control group participants enrolled within a larger study that tested an intervention for promoting lifestyle changes for cardiovascular disease risk factor reduction in adults with type 2 diabetes mellitus (T2DM). The intervention group received biweekly decision coaching based on self-selected health goals, while the attention control group received general healthcare information phone calls at the same interval. Telehealth was the topic of one of the healthcare information phone calls, and participants' self-reported experiences were written into case notes summarizing the key content of the dialog. Data were then coded for key themes and content-analyzed in relation to selected socio-demographic and clinical variables. Bivariate correlational statistics and chi-square tests of significance were used in the applicable contexts to explore associations among the variables. Results: Four major topics emerged from dialog of participants during the phone calls: (1) types of telehealth services used, (2) reasons for using telehealth, (3) factors that facilitated telehealth use, and, (4) factors that were barriers to telehealth use. Three statistically significant relationships were found between clinical variables and telehealth perceptions. First, time (years) since diagnosis with T2DM was correlated with higher HbA1C levels at baseline (r=0.51, p=0.04), indicating lower T2DM control with longer time since diagnosis. Time since diagnosis with T2DM was also associated with a higher number of perceived facilitators of telehealth use (r=0.58, p=0.02). Finally, an increased number of reasons to use telehealth (r=0.71, p=0.002) and a higher number of perceived facilitators (r=0.76, p=0.001) were correlated with current telehealth use. Discussion: For telehealth interventions to be successful, healthcare providers should understand what purposes, facilitators, and barriers are relevant to their patients. HCPs should also consider patients with complex medical conditions as potential candidates for telehealth interventions. This study contributes to an emerging body of research on patients' perceptions of telehealth. This new knowledge is a necessary basis to inform future research on the impact of telehealth in management of chronic health conditions such as T2DM. PATIENT PERCEPTIONS ON TELEHEALTH 3 Patient Perceptions on Telehealth in Chronic Disease Management With communication technology becoming increasingly present in everyday life, its use in health care is expanding (Hein, 2009; Coye, Haselkorn, & DeMello, 2009). Telehealth is a broad term that refers to the use of information technology in health care. Telehealth encompasses multiple types of electronically-based software, hardware, and health care services, and is generally characterized by the transmission of health-related information through communication technologies such as telephone or the internet (Hein, 2009). Telehealth includes programs designed to improve the services of and communication between healthcare providers (HCPs), such as e-prescribing, distance education, and online medical journal databases. Another category of telehealth service supports enhanced communication between HCPs and patients, which is of particular interest in the management of chronic diseases such as diabetes, congestive heart failure, and even psychiatric illnesses such as depression. Provider-patient telehealth services are farreaching and include telecommunication of appointment reminders or test results, electronic medical records available to both patient and provider online, video conferencing with distant specialists, mobile/smartphone applications for disease management or health promotion, and remote patient monitoring (RPM) of vital signs, daily weights, blood glucose levels, and other parameters of health and disease control. Potential benefits to both patients and providers through the utilization of telehealth programs have only recently begun to be systematically studied. Telehealth has the potential for multiple benefits because it supports the preventative, health promotion, and curative aspects of health by its very nature. It has the capacity to increase access to care by reducing costs to insurers and users of health care services. When telehealth is used successfully, fewer in-person encounters may be needed to manage health care needs (Chase et al., 2003), which could theoretically lead to decreased transportation and healthcare costs to the client. Telehealth may permit those in remote areas to have access to specialized care, which they may not have had the resources to obtain otherwise (Innovations Exchange Team, 2013). Financial benefits to the health care institution may exist, as the market for telehealth services is expected to grow due to the increasing incidence of chronic diseases, the need to improve community health, the projected increase in United States population, and the shortage of healthcare professionals (Hein, 2009). A significant potential benefit of expanding the current telehealth infrastructure is improved patient outcomes. A variety of studies have shown an association between chronic disease management through RPM and decreased emergency room visits, hospital stays, and nursing home admissions (Hein, 2009; Maudlin, Keene, & Kobb, 2006). Another study of RPM in people with diabetes has shown promising results in terms of glycemic control (Chase et al., 2003). Existing research on patient perceptions of telehealth has revealed positive attitudes overall, and many users report an increased sense of knowledge and empowerment in managing their health (King et al., 2010; Minatodani et al., 2013; Pare et al., 2007; Maudlin et al., 2006). Despite these studies of health and health system outcomes that document the potential public health impact of telehealth, a number of barriers to implementing telehealth on a wider scale are present. Infrastructure is currently inadequate to expand telehealth services to the entire population (Hein, 2009). For example, not every health PATIENT PERCEPTIONS ON TELEHEALTH 4 care practice has a system in place for private and secure telecommunication. In addition, the costs of the technology and training can be steep. One of the most prohibitive factors for providers is the lack of reimbursement for telehealth services, causing many to view implementation as an increase in workload without worthwhile compensation (Hein, 2009). Despite the fact that many studies have demonstrated positive patient attitudes toward telehealth, findings are mixed. Some patients have expressed reservations about telehealth and view it as a threat to their autonomy (Saunders et al., 2012). Furthermore, not all studies support that telehealth improves patient outcomes and is cost-effective (Takahashi et al., 2012). In summary, telehealth shows significant promise as an intervention to improve healthcare and health care outcomes. However, as a relatively new facet of healthcare, more research is needed on the efficacy of telehealth and consumers' perceptions before providers and policymakers can be convinced of its benefits. The existing research has focused mainly on the perspectives of health care providers and policymakers, with comparatively less focus on the perceptions of health care consumers. Therefore, the overall purpose of this thesis is to contribute to knowledge about how recipients of health care services perceive telehealth services. Review of Literature Chronic Disease Management and Patient Outcomes Telehealth holds great potential in the field of chronic disease management. A number of studies have demonstrated comparable or improved patient outcomes with telehealth interventions as compared to traditional in-person encounters, although research findings are mixed. A systematic review of telehealth by Pare et al. (2007) found that improved patient outcomes—as measured by decreased emergency department visits, hospital admissions, and average hospital length of stay— occurred in patients with cardiac or pulmonary disorders, but results were inconsistent among patients with diabetes or hypertension. In contrast, other research does support the efficacy of disease management programming and telehealth for improving outcomes in diabetes, a chronic disease that is associated with substantial excess health system costs and poor clinical outcomes (Centers for Disease Control and Prevention, 2014). For example, one retrospective cohort study of patients with diabetes enrolled in a telehealth management program revealed improved glycemic control as measured by decreased hemoglobin A1c (HbA1c) at three and six months (Kesavedev et al., 2012). Another study of patients with diabetes examined whether or not RPM of blood glucose levels could take the place of clinic visits and


Public digital libraries,which are developing rapidly for their convenience,high efficiency and low cost,can make massive amounts of knowledge information available to the social public easily and quickly,but are restricted by the right of communication through information network.The paper tried to expound and prove the feasibility of legal permission based on the analyze of the conflict between the non-profit digital library and copyright to balance the interests and promote the dissemination of culture and then put forward suggestions on the legal permission system of non-profit digital libraries.


The present work examines the validity of the Donnan approximation as a model for polyelectrolytes. A semi-empirical theory is presented and tested with a polymer of potassium-para-vinylbenzene sulfonate. A viscosity study was made with this polyelectrolyte in the presence of added electrolytes. The theory appears valid for fully ionized polyelectrolytes.


The recent emergence of the monkeypox virus (MPXV) in non-endemic countries has been designated a Public Health Emergency of International Concern by the World Health Organization. There are currently no approved treatments for MPXV infection in the United States or Canada. The antiviral drug tecovirimat (commonly called TPOXX), previously approved for smallpox treatment, is currently being deployed for treatment of MPXV infections where available based on previously accrued data. We tested the efficacy of TPOXX both in vitro and in vivo against a clade 2 Canadian 2022 isolate of MPXV isolated during the current outbreak. TPOXX prevented MPXV replication in vitro with an effective concentration in the nanomolar range. To evaluate TPOXX efficacy in vivo, we first characterized the CAST/EiJ mouse model with the same 2022 Canadian isolate. Unlike previous descriptions of this model, the Canadian isolate was not lethal in CAST/EiJ mice, although it replicated efficiently in the respiratory tract after intranasal infection. Subsequent experiments demonstrated that daily oral TPOXX treatment markedly reduced viral titers in the tissues 1 and 2 weeks after infection. Our data indicate that TPOXX is highly effective against currently circulating MPXV strains and could be an important contributor to curbing the ongoing outbreak. Description Tecovirimat treatment effectively inhibits monkeypox virus replication both in vitro and in vivo in CAST/EiJ mice. Monkeypox antiviral The antiviral drug tecovirimat (TPOXX) was developed to treat smallpox, which is caused by infection with variola virus, an orthopoxvirus closely related to monkeypox virus (MPXV). During this current global MPXV outbreak, TPOXX has been approved for treating infected individuals in Europe and has been used in other countries where available. Warner et al. demonstrate that TPOXX is effective against a 2022 Canadian MPXV isolate both in vitro and in the CAST/EiJ mouse model. This viral isolate is not as lethal in CAST/EiJ mice as previous isolates, despite evidence of respiratory tract replication, and appears to align with other recent isolates that define a new viral clade. Together, these findings support the therapeutic use of TPOXX against currently circulating MPXV and suggest changes in the virus that alter pathogenicity in mouse models.


Four cases of fluctuating hearing loss in West African and West Indian racial groups are presented. Two are Menière's disease, and the authors are unaware of any report in English publications describing Menière's disease in these racial groups. One is late syphilitic hearing loss and the other is idiopathic. The possible role of yaws is presented and long-held beliefs questioned.


We have studied the dynamical properties of the OPO when it is inserted into the pump laser cavity. The temporal evolutions of the population inversion, pump and signal intracavity powers are modelised by a simple system of coupled equations. Numerical simulations show that the OPO can produce one or severa1 pulses depending on the signal cavity finesse and the pumping level of the laser medium. The energy transfer from the laser medium to the signal pulses can be very efficient.


Objective:The purpose of this study was to detect the signaling pathways involved in angiotensinⅡ(AngⅡ)-induced mesangial cell(MC) proliferation.Methods:The incorporation of 3H-thymidine(3H-TdR) and cell count were used as the measure of mesangial cell proliferation.Reactive oxygen species(ROS) production was determined by DCFDA fluorescence.Nicotinamide adenine dinucleotide phosphate(NADPH) oxidase activity was examined by lucigenin chemiluminescence.c-Jun animoterminal kinase(JNK) activation was assayed by Western blot.Results:AngⅡ time-dependently and dose-dependently increased intracellular ROS produc-tion in cultured human MCs as early as 3 min and peak at 60 min.Incubation with different dose of AngⅡ(1 nmol / L,10 nmol / L,and 100 nmol / L AngⅡ) for 60 min,ROS production increased for 1.82-,2.92-,and 4.08-fold,respectively.AngⅡ-induced ROS generation was inhibited by the AT1R antagonist losartan but not the AT2R antagonist PD123319,as well as NADPH oxidase inhibitors diphenyleneiodonium sulfate(DPI) and apocynin.In contrast,inhibitors of other oxidant-producing enzymes,including rotenone,allopurinol,indomethacin,nordihydroguiaretic acid,ketoconazole and G-nitro-L-arginine methyl ester(L-NAME) have no effect on AngⅡ-induced ROS production and MC proliferation.AngⅡ treatment induced translocation of cytosolic of p47phox and p67phox to the membrane and p47phox and p67phox gene expression.Conclusion:NADPH oxidase-derived ROS involved in AngⅡ-induced JNK / AP-1 activation and mesangial cell proliferation.


We derive a factorization theorem for the jet mass distribution with a given pTJ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_T^J$$\end{document} for the inclusive production, where pTJ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_T^J$$\end{document} is a large jet transverse momentum. Considering the small jet radius limit (R ≪ 1), we factorize the scattering cross section into a partonic cross section, the fragmentation function to a jet, and the jet mass distribution function. The decoupled jet mass distributions for quark and gluon jets are well-normalized and scale invariant, and they can be extracted from the ratio of two scattering cross sections such as dσ/(dpTJdMJ2)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$d\sigma/(dp_T^JdM_J^2)$$\end{document} and dσ/dpTJ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$d\sigma/dp_T^J$$\end{document}. When MJ∼pTJR\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$M_J \sim p_T^JR$$\end{document}, the perturbative series expansion for the jet mass distributions works well. As the jet mass becomes small, large logarithms of MJ/(pTJR)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$M_J/(p_T^JR)$$\end{document} appear, and they can be systematically resummed through a more refined factorization theorem for the jet mass distribution.


This paper analyses the newly issued "The Norms of Professional Ethics of Librarians in China", on the basis of Ethics theory, and expounds that after the establishment of the professional ethics of librarians, the focus of the construction of library professional ethics is on the development of the consciousness of librarian professional ethics, which guides and dominates all the professional ethical activities.


The efficiency of polyaniline/Fe 3 O 4 (PANI/Fe 3 O 4 ) nanocomposite (NC) as an adsorbent was investigated in the removal of Titan yellow (TY) dye from aqueous solution.  The PANI/Fe 3 O 4 was synthesized by polymerization of aniline in H 2 SO 4 medium in the presence of Fe 3 O 4 nanoparticles with ammonium persulfate as an oxidant.  The NC formed was characterized by SEM and FT-IR methods. The dye removal process was studied under various conditions and was found that the adsorption activity of the PANI/Fe 3 O 4 NC  was greater than that of the bare PANI and Fe 3 O 4 nanoparticles. Adsorption kinetics fitted with pseudo-first-order kinetic model.


0.05). The cardioprotective effects of morphine were abolished by naloxone or glibenclamide completely.Conclusions Morphine can reduce ischemia-reperfusion injuries in isolated rat heart. The cardioprotective effects of morphine are mediated by a local opioid receptor-KATP channel linked mechanism in rat hearts.


ABSTRACT

Widya Ngesti Pramono, 2015: Influence of Job Stress and Work Load Againts Job Satisfaction (Study of Taxi Driver At PT. Express Pool Bekasi C). Skripsi, Jakarta: Concentration of Human Resources Management, Study Program of Management, Departement of Management, Faculty of Economics, State University of Jakarta.

The purpose of this study were: 1) to know the overview of job stress, work load, and job satisfaction the taxi drivers at PT. Express Pool Bekasi C. 2) to know the influence of job stress on job satisfaction. 3) to know the influence of work load on job satisfaction. 4) to know the influence of job stress and work load simultaneously on job satisfaction. The analysis conducted in this research is descriptive analysis and correlation causality. Research carried out by the simple random sampling method on 171 taxi drivers at PT. Express Pool Bekasi C as respondents, while the technique of data collection is done by distributing questionnaires, which is processed using SPSS 16.0. The results of the regression indicates that there is influence between job stress on job satisfaction, and there is influence between work load on job satisfaction. Job stress and work load simultaneously influence the job satisfaction. This research has figured out the score of job stress and work load on job satisfaction is 0,805 or 80,5% through the result of adjusted R2 value while the rest is 19,5% is influenced by the other
factors.

Key words: job stress, work load, job satisfaction


Limited economic resources create constraints that force trade-offs among desired objectives. Likewise, state-balanced budget requirements force policy makers to make budgetary trade-offs among competing state programs. Constrained state resources have also encouraged states to issue bonds to finance infrastructure and capital assets rather than using pay-as-you-go financing for such investments. However, the expanded use of debt financing often faces another constraint known as debt capacity. As a result, states may be required to make trade-offs among the competing demands for debt financing similar to the trade-offs they must make for operating program expenditures. The authors' empirical findings indicate that tradeoffs occur between highway project—related debt and other state debt in those states with formal restrictions on total general obligation and revenue-backed debt (umbrella debt limits). In states without umbrella debt limits, there is no evidence of a trade-off between the highway debt and all other state debt.


PURPOSE: A method, game server, recording medium, and a game apparatus for providing sports game is provided to enable a user to scout desired player by offering a free agent market function. CONSTITUTION: An free agent market opening unit(210) controls a user terminal to be displayed on a menu screen. An unprotected player exposing unit(220) controls information of a plurality of free agent player to be displayed on the free agent market menu screen. A negotiation-related information exposing unit(230) exposes player evaluation information and negotiation costs information on the free agent market menu screen.


There has been little empirical research on the gender role socialization of Jewish men. This paper explores Jewish male gender role socialization and provides a model by which gender and ethnicity may be studied. A description of the gender role socialization of Jewish men, with an emphasis on advantages and disadvantages of such socialization from a developmental perspective, is presented. Special attention is given to messages received from parents in early childhood, peer interactions, and adult family life. Additionally, ways in which Jewish men compare themselves to other men are examined. It seems that the gender role socialization of Jewish men may cause diminished self-esteem in childhood and adolescence, with the rejection of Jewish cultural values as a possible outcome. Jewish boys are likely to admire the stereotypical American male, thereby discounting the image of the Jewish man. Emulation and denigration of certain stereotypical traits of other racial/ethnic minority men sometimes occurs. However, in mid-life, Jewish men may embrace the values that were once rejected, finding a wealth of prelTiously unexplored resources from early socialization. Rejection of the dominant culture's ideal man follows, leaving a strengthened Jewish identity. (RJM) Reproductions supplied by EDRS are the best that can be made from the original document. U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER tERICI ThIS document has been reproduced as received from the person or organization Originating it C Minor changes have been made to improqe reproduction quality Point s ol view or opinione Stated in this dcc u ment do not necessarily represent otficial OE RI position or policy C) C\J


The invention relates to a circular turning tool for ceramic excircle processing and an axial processing method thereof, which belong to the field of the non-traditional processing in machining. The tool mainly comprises a tool handle, a tool body and a tool head which are sequentially and coaxially connected; the tool handle, the tool body and the tool body are hollow round pipes, and the tool body wall is provided with a balance groove; and the tool head comprises tool teeth, through slots formed between every two tool teeth and tooth sockets processed on the inner surface of the tool teeth. The method axially turns the excircle to cylindrical ceramic material through the high-speed rotation of the circular tool; the tool head bottom end surface of the circular tool serves as the main cutting surface removing material, and the inner surface of the tool head of the circular tool serves as an auxiliary cutting surface and grinds the excircle surface of processed work piece; and the rotating speed of the tool is 4000 to 20000r/min, and the rotating speed of the work piece is 0 to 5000r/min. The invention can process the excircle of engineering ceramic material with high efficiency, and has the advantages of simple process, easy operation and lower cost.


Visualization in the emerging field of topological data analysis has progressed from persistence barcodes and persistence diagrams to display of two-parameter persistent homology. Although persistence barcodes and diagrams have permitted insight into the geometry underlying complex datasets, visualization of even single-parameter persistent homology has significant room for improvement. Here, we propose a modification to the conventional persistence diagram - the flat persistence diagram - that more efficiently displays information relevant to persistent homology and simultaneously corrects for visual bias present in the former. Flat persistence diagrams display equivalent information as their predecessor, while providing researchers with an intuitive horizontal reference axis in contrast to the usual diagonal reference line. Reducing visual bias through the use of appropriate graphical displays not only provides more accurate, but also deeper insights into the topology that underlies complex datasets. Introducing flat persistence diagrams into widespread use would bring researchers one step closer to practical application of topological data analysis.


OBJECTIVE To investigate the protective effects and mechanism of nicorandil(Nic),glutamine(Glu)and metoprolol(Met)used in single or combination against myocardial ischemia reperfusion(IR)injury in vivo in rats.METHODSMale Wistar rats were divided randomly into seven groups:(1)sham operated group:didn't ligate the coronary artery;(2)IR group:only 30 min ischemia and 120 min reperfusion of LAD was conducted;(3)Nic group;(4)Glu group;(5)Met group;(6)Nic+Glu+Met(NGM)group;(7)low dose of Nic+Glu+Met(NGML)group.In the pharmacological precondition groups,the corresponding drugs were administrated ahead 30 min of IR protocol,and the initial drug doses were 1 mg·kg-1(1 mg·ml-1),1 mg·kg-1(1 mg·ml-1),1 mg·kg-1(1 mg·ml-1).Heart physiology of each group during the period of IR was monitored.Assessed the myocardial infarct size and morphology after IR.At the end of the reperfusion,the activity of creatine kinase-MB(CK-MB)、myeloperoxidase(MPO),superoxide dismutase(SOD)and malonaldehyde(MDA)in the plasma of rats were measured.RESULTS Compared with single therapy after IR in rat,the combination therapy of Nic,Glu and Met could do better in the following aspects:strengthening heart physiological function obviously;shrinklng IS and improving morphological changes caused by IR;redu reducing CK-MB leakage and MPO secretion;increasing the antioxidation ability of cardiocytes through elevating SOD activity and reducing MDA content.CONCLUSION The combination therapy of Nic,Glu and Met can protect against IR.


Linear ubiquitination is a key posttranslational modification that regulates immune signaling and cell death pathways, notably tumor necrosis factor receptor 1 (TNFR1) signaling. The only known enzyme complex capable of forming linear ubiquitin chains under native conditions to date is the linear ubiquitin chain assembly complex, of which the catalytic core component is heme‐oxidized iron regulatory protein 2 ubiquitin ligase‐1–interacting protein (HOIP). To understand the underlying mechanisms of maintenance of liver homeostasis and the role of linear ubiquitination specifically in liver parenchymal cells, we investigated the physiological role of HOIP in the liver parenchyma. To do so, we created mice harboring liver parenchymal cell–specific deletion of HOIP (HoipΔhep mice) by crossing Hoip‐floxed mice with albumin–Cre mice. HOIP deficiency in liver parenchymal cells triggered tumorigenesis at 18 months of age preceded by spontaneous hepatocyte apoptosis and liver inflammation within the first month of life. In line with the emergence of inflammation, HoipΔhep mice displayed enhanced liver regeneration and DNA damage. In addition, consistent with increased apoptosis, HOIP‐deficient hepatocytes showed enhanced caspase activation and endogenous formation of a death‐inducing signaling complex which activated caspase‐8. Unexpectedly, exacerbated caspase activation and apoptosis were not dependent on TNFR1, whereas ensuing liver inflammation and tumorigenesis were promoted by TNFR1 signaling. Conclusion: The linear ubiquitin chain assembly complex serves as a previously undescribed tumor suppressor in the liver, restraining TNFR1‐independent apoptosis in hepatocytes which, in its absence, is causative of TNFR1‐mediated inflammation, resulting in hepatocarcinogenesis. (Hepatology 2017;65:1963‐1978).


The concept of 'seeing land from the sea' (Cooney 2003: 323) has gained currency since the themed World Archaeology issue, 'Seascapes' (2003), building upon 'maritime cultural landscape' studies by Hunter (1994: 261), Jasinski (1999: 14-18), Parker (1999, 2001) and Westerdahl (1992, 2002). Since this time, however, few case studies have explored the practical methods that can be employed to incorporate such thinking into maritime archaeology studies. Are maritime archaeologists around the world embarking on survey vessels and pursuing a 'seaward perspective' (Phillips 2003: 376) or are there 'water views' (Guthrie and Kohen 2005: 16) that are yet to breach the conceptual barrier of the office door?


By examining muscular Christianity and its legacies, with particular attention to history's twilight zone, we can add to the genealogy of contemporary politics in unexpected ways, and unsettle our sense of contemporary institutions. This essay examines the history of the present, seeking insight into decolonization and postcoloniality via a study of baseball in the Caribbean. It looks at the relations between the region and Organized Baseball with a focus on how Organized Baseball manages its relationships in the new world order, challenging the narrative that US citizens brought baseball to the Caribbean and that Caribbean players and teams hoped some day to catch up to US leadership. Baseball in the Caribbean provides an excellent ground for observing the impact of the US-led new world order on complex social relationships.


miRNAs are a class of endogenous small non-coding RNAs that play important roles in regulating gene expression.It has been demonstrated that numerous miRNAs were able to modulate adipocyte differentiation,including miR-191.The pre-miR-191 and matured miR-191 were conserved among mammals.The results of Solexa sequencing showed that the miR-191expression fluctuated during adipogenesis.We examined the expression level of miR-191 in 3-day and 180-day old large white pigs,detected significant differences.To investigate the influence of miR-191 on adipocyte differentiation,an adenovirus vector was constructed with the Ad-Easy system.The adipose derived stromal cells(ADSCs) were infected by Ad-miR-191.The results indicated that overexpression of miR-191 dramatically reduced the mRNA expression level of SREBP-1C and LPL.Meanwhile,the lipolysis related genes HSL and ATGL mRNA expression levels increased remarkably.The overexpression of miR-191 also led to a notable reduction in lipid droplets in porcine pre-adipocytes as detected by oil red O staining.The Western blotting results indicated that the expression of PPARγ,C / EBPα and A-FABP proteins gradually reduced for 8 days in ADSCs with miR-191 overexpression as compared to the control cells.In conclusion,we vertifed that miR-191 inhibited the ability of ADSCs differentiation in vitro,and demonstrated the importance of miR-191 in the biological mechanisms for adipogenesis regulation.


Recent studies have shown how a gene's promoter can be used to drive expression of a selectable marker for functional genomic screens to identify cDNAs that can activate transcription of a target gene [Takahashi et. al, Cell, 2006 126: 1–14]. Our goal was to identify a promoter that was specifically active as cells enter the cell cycle, but that was inactive in arrested or quiescent (G0) cells. We chose the human Ki67 gene because it is a commonly used marker for cellular proliferation and used PCR to clone the Ki67 1.5 kb proximal promoter (−1233–+291). Comparative genomic analysis of this fragment reveals several highly conserved E2F transcription factor binding sites, suggesting that it is under control of E2F transcription factors, which are known to regulate the G1‐S phase of the cell cycle. Expression of GFP driven by the 1.5 kb Ki67 promoter results in cellular colocalization of GFP with endogenous Ki67 protein in HT1080 cells. Furthermore Ki67 promoter activity is attenuated by serum starvation or treatment with mitomycin C, evidence in support of its specificity for proliferating cells. In conclusion, the Ki67 promoter provides a useful molecular tool that could have a variety of applications, including rapid functional genomics screens that seek to identify novel oncogenes and tumor suppressors as well as for in vivo identification of cellular proliferation in transgenic animals (Supported by UCSD IRACDA training fellowship).


The objective of this work is to evaluate if modifying the technique of open thyroidectomy, without myocutaneous flaps, gets a good procedure with a shorter ...


Professor Adela Yarbro Collins, we met in person only recently on the SBL Council, but, like the hundreds of other students who passed through your class room, the hundreds of scholars and students who drank from the wells of your research, and the many institutions that benefited greatly from your academic lead ership, I do count myself to be among your mentees. In the late 1980s, when I made my journey to postgraduate studies in New Testament literature, your edited anthol ogy Feminist Perspectives on Biblical Scholarship was among the first four volumes on feminist biblical interpretation that I read.1 Not only did the book help me to formulate my questions, but it also gave me the skills of reading the Bible as a woman who lived, and still lives, in many patriarchal spaces. Given that historical criticism and exegesis were rarely attending to issues of gender during that time, your pioneering anthology was an oasis in the desert, for it gave me the right to dare to read the Bible academically as a woman.


The absorbed ultrasound energy is changed into heat in a dissipative medium. This could be of great advantage in treating tumors in a noninvasive manner, by raising their temperature to cytotoxic levels. In this study we investigated whether using a fixed-focus transducer can destroy breast tumor cells, especially in early stages, in a cost-effective manner and reduce treatment time significantly. An appropriate fixed-focus transducer was designed, and the resultant acoustic pressure was calculated by solving the Rayleigh integral. A two-dimensional breast model was constructed from the magnetic resonance image (MRI) of a cancerous breast. Then, the induced temperature elevation was calculated using the bioheat equation and applying the finite element method (FEM) to the model. Results demonstrate that this transducer can generate a temperature of up to 61 °C in 3 s, which is sufficient to destroy cancer cells, particularly in early stages.


The optimal vitamin D supplementation plan during lactation is unclear. We investigated the effect of maternal vitamin D supplementation on mother-infant dyads' vitamin D status during lactation. All controlled trials that compared vitamin D supplements to placebo or low doses of vitamin D in breastfeeding mothers were included. Pooled effect size and the associated 95% confidence interval (CI) for each outcome were estimated using random-effects models. A one-stage random-effect dose-response model was used to estimate the dose-response relation across different vitamin D dosages and serum 25-hydroxy vitamin D (25(OH)D) concentrations. We identified 19 clinical trials with 27 separate comparison groups (n = 3337 breastfeeding mothers). Maternal vitamin D supplement dosages were associated with circulating 25(OH)D concentrations in breastfeeding women in a non-linear fashion. Supplementation with 1000 IU of vitamin D/day increased serum 25(OH)D concentrations by 7.8 ng/mL while there was a lower increase in concentrations at vitamin D doses of >2000 IU/day (3.07 and 2.05 ng/mL increases between 2000 to 3000 and 3000 to 4000 IU/day, respectively). A linear relationship was observed between maternal vitamin D supplementation dosage and the infants' circulating 25(OH)D concentrations. Each additional 1000 IU of maternal vitamin D intake was accompanied by a 2.7 ng/mL increase in serum 25(OH)D concentration in their nursing infants. The subgroup analysis showed that maternal vitamin D supplementation was accompanied by a statistically significant increase in infants' 25(OH)D concentration in the trials with a duration of >20 weeks, vitamin D supplementation >1000 IU/day, East Indian participants, maternal BMI <25 kg/m2, and studies with an overall low risk of bias. Long-term maternal supplementation with vitamin D at a high dose (>6000 IU/day) effectively corrected vitamin D deficiency in both mothers and infants. Nevertheless, infants with 25(OH)D concentrations over 20 ng/mL may require a relatively low maternal dose to maintain vitamin D sufficiency.

STATEMENT OF SIGNIFICANCE
This study is the first dose-response analysis on the relation between circulating 25-hydroxy vitamin D (25(OH)D) and maternal vitamin D supplementation in mother-infant dyads. We also considered factors such as study design and population characteristics that may affect the outcomes of a given vitamin D trial that have been overlooked in previous reviews.


ABSTRACT Around the world, shoreline communities such as Norfolk, Virginia are seriously threatened by sea level rise. In previous decades, before the risks associated with climate change were widely understood, millions of dwellings were built in areas now prone to flooding. These dwellings, representing billions of dollars in investment, are occupied by billions of people. The appropriate response to rising waters is to stop making unwise settlement decisions along the shore; pursue short-term fixes that, in some coastal communities, can buy time; and retreat from the coast where necessary. In the United States, however, public policy continues to incentivize unwise development decisions, as do the practices of the finance and insurance industries. Little evidence suggests that the United States will soon alter its approach to sea level rise.


The paper's main goal is to use ratio analysis to examine the bank's overall financial situation. It demonstrates if the company is getting better or worse over time. The last five years worth of yearly reports from cub serve as the study's primary source of secondary data. Ratio analysis offers a foundation for both intra and inter firm comparisons. For great ease of understanding ,visual representations are employed. For a variety of stakeholders, including management, financiers, stakeholders, and creditors among other tools are helpful tools. In this study several ratio types are examined. This report provides information on the firm financial status as well as identifies issues and makes recommendations for how to fix them. Keywords: profitability, ratio analysis


In care-physical activity (care-PA) initiatives, primary care and sports collaborate to stimulate PA among adults at risk of lifestyle related diseases. Preliminary results of Dutch care-PA initiatives for low socioeconomic status (SES) adults indicate that these initiatives successfully lower participants' body weight and improve quality of life. However, insight into elements that make these initiatives work is lacking. Therefore, this research aims to unravel the effective elements of care-PA initiatives for low SES adults.

 Concept Mapping (CM) was used as tool to identify and cluster the effective elements. Nineteen Dutch health promotion experts individually listed as many elements as they felt were of importance to the effectiveness of care-PA initiatives. Next, each expert was asked to cluster the elements and to score them on importance. Then, CS Global MAX software was used for multidimensional scaling and a hierarchical cluster analysis to develop a cluster map. Finally, the cluster map was presented, discussed, and refined in a group meeting with 11 of the experts.

 The experts came up with 113 unique effective elements of care-PA initiatives for low SES adults, clustered into 11 clusters: 1) approach of professionals, 2) barriers experienced during the programme, 3) local embedding, 4) customisation of the programme to target population, 5) social support, 6) methods within the programme, 7) competencies of professionals, 8) accessibility of the programme, 9) actions within the programme, 10) recruitment of participants, and 11) intersectoral collaboration.

 A valuable overview of the effective elements of care-PA initiatives for low SES adults was created. The results can be used to improve existing care-PA initiatives and to develop new ones targeted at low SES adults at risk of lifestyle related diseases. This may eventually help to reduce health inequalities between low and high SES adults.

 Concept mapping has been a useful group-based tool to obtain information on the effective elements of care-PA initiatives, in which individual input from health promotion experts has been collected. The overview of effective elements of care-PA initiatives for low SES adults as presented in this study is valuable for the development of care-PA initiatives specifically targeted at low SES adults.


S Psychiatria Danubina, 2022; Vol. 34, Suppl. 1, pp 26-888 S252 the anxiety degree of consumers was evaluated by Self-rating Anxiety Scale (SAS) and Hospital Anxiety and Depression Scale (HADS). Study design: 100 consumers were randomly divided into study group and control group by random number table method, with 50 people in each group. Among them, consumers in the research group used the improved e-commerce model based on consumer psychology to shop and consume. The consumers in the control group used the traditional e-commerce model for shopping and consumption. One month later, the anxiety levels of the two groups of consumers were compared. Methods: The relevant data were processed and analyzed by software SPSS17.0. Results: After one month of consumption, the SAS score of consumers in the study group was significantly lower than that of consumers in the control group (P < 0.05), as shown in Figure 1. 0 10 20 30 40 50 60 70 80 90


The effect of temperature on the densities and viscosities of aqueous solution of poly(acrylic acid) (PAA) of different mass fraction (from 0.05 to 0.50) and liquid−liquid equilibrium, densities, and viscosities for the aqueous two-phase PEG-6000 + PAA + water system at equilibrium have been measured. The densities and viscosities of the PAA + water system at different temperatures were correlated as a function of mass fraction. The binodal curves for the PEG + PAA + water system have been correlated using a four-parameter equation. The increase in temperature results in an increase in the two-phase region. The tie line compositions have been fitted to both the Othmer−Tobias and the Bancroft equations. A linear dependency of both the plots indicates the consistency of the data; however, the Bancroft equation gives the best fit.


The brake shoe support assembly is able to track the lateral movement of a wheel, typically a wheel on an axle truck that allows lateral wheel movement. In operation, a flange of the wheel pushes on one side of the brake shoe support assembly, pushing it along a pin, and compressing a resilient biasing structure. As the wheel returns to a center or neutral position, the compressed resilient biasing structure expands pushing the brake shoe support assembly back to an original or neutral position. The resilient biasing structure also minimizes the lateral movement of the brake shoe support assembly down the wheel taper under normal braking loads thus preventing shoe ride-off. The resilient biasing structure may be enclosed in a housing adapted to prevent the intrusion of contaminants.


This paper presents a new power control strategy of grid-connected converter under grid fault conditions. Positive-and negative-sequence reactive power are controlled separately in order to effectively support unbalanced grid voltage. Both maximum phase current limit and maximum active power oscillation limit are taken into consideration which makes the converter operate safely under grid faults. Spare capacity are fully used to generate active power. Reactive power is generated immediately and active power is generate gradually during calculation procedure which makes it possible for online application. Also, generating active power gradually lighten the burden of crowbar or other energy transfer devices and bring less impacts to grid. Experiment results prove that the proposed method is effective.


This paper does an empirical research on school production efficiency of educational resource in chinese compulsory education, using the DEA model, Tobit model and other statistical methods. Results show that: (1) The school production efficiency of educational resource in the middle-eastern area of China is not satisfactory. Therefore, it is a feasible way to improve school production efficiency; (2) There are big differences in school production efficiency scores among different region, urban-rural and different school type; (3) The proportion of full-time teacher with qualified education, the control degree of school under government and the entent of school competition have statistically significant effects on school production efficiency of educational resource.


Nearest neighbor classifiers with direct sum successive approximation (DSSA) templates are shown to be effective for detecting and discriminating mines and mine-like objects in forward looking sonar data. DSSA results are demonstrated on data obtained form field measurements with actual mines and calibration targets. The DSSA templates are used in a nearest neighbor classifier that can be characterized as a new type of radial basis function neural network. This neural network is not designed with a preset complexity level as quantified by an a priori determined number of degrees-of-freedom. Rather, the system is constructed incrementally and adds additional degrees-of-freedom as required by the nature of the training data. The neural net system possesses stage structure that result in inherent computational and memory efficiency in searching and storing the DSSA-based radial basis functions.


INTRODUCTION Quinazolinone are the derivatives of quinazolines containing keto or oxo group based on the positions are classified as 2-(1H) quinazolinone (or) 1,2-dihydro-2-oxo quinazolines and 4(3H)quinazolinone or 3,4-dihydro-oxoquinazolines. These two system exhibit lactam-lactim tautomerism and undergo hydroxyl group replacement reactions [1]. Commonly β-lactam chemistry is of great importance because of the use of β-lactam derivatives as antibacterial agents. The molecular mode of action of the β-lactam antibiotic is selective and irreversible inhibition of enzymes processing the developing peptidoglycan layer {2}. Quinazoline and condensed Quinazoline exhibit potent central nervous system (CNS) activities like anti-anxiety, analgesic, anti-inflammatory and anticonvulsant. Quinazolin-4-ones with 2, 3disubstitution is reported to possess significant analgesic, anti-inflammatory. It is clear from literature review that a number of quinazolinone derivatives are known for the Analgesic [3], Anti-inflammatory [3], antibacterial [4], antifungal [4], Anti depressant [5],Anti-HIV [6], anticonvulsant [16], Anti-oxidant [8], Cytotoxic [9] Anti-viral [11]. The present studies were performed with the objective of Synthesis of new series of quinazolinone derivatives. Quinazolinone derivatives were synthesized by anthranillic acid react with benzoyl chloride to form benzoxacinone using hydrazine hydrate and condensed by various compounds like chloro benzaldehyde, chloro amino thiadiazole, ketones,mercaptoacetic acid to gives quinazolinone derivatives. Characterization of newly synthesized compounds by spectra methods via infrared spectra (IR spectra), Nuclear magnetic resonance spectra (1H NMR spectra) and Mass spectra. Screening of analgesic, anti inflammatory and anti bacterial activities of the newly synthesized compounds [4].


This text summarises the 2016/17 winter forecast of the KOF Swiss Economic Institute at ETH Zurich, released on 15 December 2016. The first part discusses recent economic developments abroad and in Switzerland, and presents the main forecast results across the various sectors of the economy. In the second part, the forecasts for Switzerland follow. The third part contains a closer look at the international economy. We expect the Swiss economy to grow by 1.4% in 2016, 1.6% in 2017 and 1.9% in 2018, respectively. Compared with our last forecast in October 2016, this amounts to a slight downward revision for the current and the upcoming year, which is mainly due to the newly available provisional data for the third quarter 2016.


Pleomorphic adenoma (PA) is the most common salivary gland tumor. Tumors originating from the major salivary glands are frequently located in the parotid gland. In contrast, tumors originating from the minor salivary glands are frequently found in the palatal region. PA occurring in the lips, especially the lower lip, is relatively rare.In this paper, we present 2 cases of PA arising in the upper lip and lower lip, respectively.The first case arose in a 72-year-old woman. The patient visited a dental clinic because of swelling of the left side of the upper lip and was referred to our department. Palpation revealed a painless movable mass. The lesion was 15 mm in diameter and located in the subcutaneous tissue on the left side of the upper lip.The second case was in a 60-year-old man. This patient visited a dental clinic because of swelling of the left side of the lower lip and was referred to our department. Palpation revealed a painless movable mass. The lesion was 13 mm in diameter and arose in the subcutaneous tissue of the left side of the lower lip.The clinical diagnosis in both cases was a benign tumor of the lip. Surgical resection was performed under local anesthesia in both patients, and the histopathological diagnoses confirmed PA. In both patients, the upper and lower lips healed well after the operation. About 1 and a half years after surgery, there was no evidence of recurrence.


The general election held on 21 May 1995 crowned Belgium's much heralded and long awaited federalisation, for the first time applying a recently reformed constitution's blueprint for national, regional and linguistic community governance. By Belgian standards, the event was an exceptional exercise in democracy: 6.3 million voters chose representatives to a new and much smaller Chamber of Representatives, a refashioned Federal Senate, three autonomous regional parliaments (Flanders, Wallonia, Brussels‐Capital), and a Community Council for the country's German‐speaking population. The result was an astounding reprieve for two scandal‐plagued Socialist parties and a deliverance from electoral disaster for Jean‐Luc Dehaene's centre‐left coalition government.


with the parallelism of task implementation, spatial distribution, well system fault tolerant capability and scalability, the multi-agent are widely used in many fields. The multi-agent synchronization control technology has been becoming a hot research at home and abroad. This paper set up unified time and frequency models of both homogenous and heterogeneous-agent, to explore the expression of multivariate time consistency problem. In addition, exploring the received signal strength (RSS) based time synchronization algorithm can enlarge the action range of multi-agent with keeping topologically connection, it also can ensure time synchronization and distance measurement when multi-agent lose satellite positioning function.


To fully profit from the advantages of high-K materials in metal-oxide-semiconductor gate insulator stacks, the reduction in the silicon oxide interfacial layer thickness is being pursued. In the framework of the percolation model, we explore the effects of reducing the interfacial layer thickness on the dielectric breakdown of the gate stack. If the reduction in interface layer thickness is performed at constant equivalent oxide thickness, a significant improvement of oxide lifetime is predicted. Our results also suggest that it is possible to scale the equivalent oxide thickness without degrading the breakdown-related reliability.


Phenolic cyclisation of 2-(3-hydroxyphenyl)cyclohexylamine (15) with aromatic aldehydes gave 6-aryl-1,2,3,4,4a,5,6,10b-octahydrophenanthridin-7-ols (3) and (4) cyclised at the ortho-position to the hydroxy-group together with the usual 9-hydroxy-derivatives (5), (6), and (7); compounds (3), (5) and (6) were also synthesised by Bischler–Napieralski reaction of the benzamide (23) of 2-(3-methoxyphenyl)cyclohexylamine, followed by reduction and demethylation. Moreover, the reaction of (15) with six aliphatic ketones gave the corresponding 6,6-disubstituted phenanthridines.


,C/cdrrr C'eirsrnrr. ! YYR. 5/31; 710 The effect of maturing systems (single vs groups) of ovine oocytes was silldied to examine the oocyte development in vitro. Oocytes were aspirated from follicle ovaries collected at local abattoirs Cibinong West Java, using a 18-G needle. Aspiration medium consisted of HI99 + 2 % FCS + 50 pg/ml Heparin and the maturating medium (IVM) consisted of B 199 10 90 FCS + 10 lg/ml FSH + 10 Cig/~nl hCG + 1 Llg/ml Estradiol. The oocytes collected were divided into three p ro~~ps and treated separately as follows: TI) oocytes were (natured singly in 50 IVM medium. T2) every five oocytes was matured in'5O IVM 1nedi111n and T3) every 10 oocytes was matul-cd in 50 IVM medium. AIi oocytes were maintained in incubator with 5 % CO, and high humidity at 38 "C for 20 11. The resulting ova were stained in 1 % lacmoid then rsalnincd for meiosis division under a ~nicroscope. There was a significant effect among treatments on the proportion oocytes reaching metaphase I 1 (P<0.05). The oocytes nlatured singly showed a lower proportion of the metaphase I1 compared to those mat~~red in groups. Oocytes cultured singly tended to arrest in the metaphase I and anaphase I. Oocytes matured in groups (5 to 10 oocytes per 50 p1 IVM drop) resulted a higher proportion in achieving the metaphase 11 stage compared tq those matured singly.


In the pixel 11, the floating semiconductor regions FD accumulates charge from the photoelectric conversion element PD. Charge transfer path to claim 1 CTP1 reaches the floating semiconductor region FD via the accumulation diode SD from the photoelectric conversion element PD. Charge transfer path of a 2 CTP2 reaches the floating semiconductor region from the photoelectric conversion element PD. AMP output unit provides a signal according to the potential of the floating semiconductor region FD. Charge transfer path to the first CTP is from the shutter switch TR (GS1) of claim 1 for controlling the transfer of charge from the photoelectric conversion elements PD, and the accumulation diode SD for accumulating charge from the photoelectric conversion elements PD, accumulation diode SD floating semiconductor region PD to the charge, and a transmission switch TR (TF1) for controlling the transfer, charge transfer path of a 2 CTP comprises a shutter switch TR (GS2) for controlling the transfer of charge from the photoelectric conversion element PD.


The construction method and parameters of blasting compaction engineering for deep thick silty soil and those for shallow silty soil are different.According to the features of deep thick silty soil and combining the real practice of blasting compaction construction of Wenzhou Deepwater Port Embankment Project,this paper deals with the principle,construction technology,construction parameters selection and inspection of blasting compaction for deep thick silty soil,which may serve as a reference for construction of similar projects.


Sensors, smart meters and IoT devices are key parts of the Building Information Systems. The amount of data generated from these sources is vast and the need for storage, fusion with secondary datasets (such as weather data) and aggregations has arisen in order to enhance building automation control activities. These data are stored on various data-sources, relational and non-relational, using different data formats. The combination of data coming from multiple data-sources constitutes a hard task, since each database uses different query language and structure. However, by combining all the available data-sources, it would be beneficial to reduce the volume of data during the training process. This paper presents an architecture that combines data from multiple data-sources (Databases, Object Storages, Building Information Systems) and create pipelines for aggregating the overall data.


Magnetic resonance (MR) based partial volume correction (PVC) compensates for the limited spatial resolution of positron emission tomography (PET) by using higher-resolution MR images to determine the fractional contributions of small anatomic structures to observed voxel activities. The efficacy of a PVC algorithm depends on correct estimation of imager resolution and accurate PET-MR image co-registration. The purpose of this study was to investigate the regional effects of these errors. Simulated PET and segmented MR data were generated using the Zubal MR brain phantom. Structures were classified as gray matter (GM), white matter (WM) or cerebral spinal fluid (CSF) to form a three-compartment segmented MR image. PET images were simulated by assigning known activities to each segmented MR tissue (10:3:1 GM:WM:CSF) and blurring (4 to 12 mm FWHM). With the above two datasets as inputs, the effects of resolution mismatch and misregistration on the corrected GM activity returned by a PVC algorithm were observed. Mean regional gray matter recovery (GMR) was calculated for each GM structure defined by the Zubal phantom. GMR values were then related to structure dimension and location characteristics. Regional GMR variations in the original simulated PET data were nearly eliminated after ideal PVC but resurfaced, although to a lesser extent, when resolution mismatch and misregistration were introduced. Regional GMR error was found to be related to the surface area to volume ratio of the region and the fraction of gray matter of adjacent regions.


This paper explains the design method of digital filter, analyses the design process of IIR and FIR digital filter with MATLAB . The practical research finds that students can enhance geist understanding of designing digital filter by using MATLAB in teaching ,and the teaching turns out with good effect.


The use of home cultural schemas in English interactions in an English-speaking host country as a form of discrepancy leading to misunderstanding. This study investigated the pragmatic transfer phenomenon, namely the use of Javanese culture in English conversation. It aimed at finding an occurrence of pragmatic transfer in the Javanese English conversation in the host country; the conversation strategies the transfer takes place, and the tendency of pragmatic transfer in the conversational strategies. The data were collected through semi-structured interviews and field notes. The analysis used the narrative analysis using vital emergent themes based on the pragmatic transfer principle, the conversational strategy, and the Javanese norms. The result indicated the availability of negative and positive pragmatic transfer in four strategies: making the most of others' praise, indirect response, denial over compliments, mitigating taboo or imposition marked with Javanese terms, idioms, and jargon insertion. Besides, motivation is an essential aspect that determines the existence of pragmatic transfer in English interactions.


Reviews the book "The Power of Problem-Based Learning," edited by Barbara J. Duch, Susan E. Groh, and Deborah E. Allen.


The content of this project is to consider historical background,
toptgraphy, invirnment, national traits, and local characteristics,
And then through choosing the architects of each country and
analysing the example of the works. Next, by searching what
effects local characteristics have on architectural works, I
will recognize importance of local characteristics. That is
purpose of this study.
Also, through simultaneously contemplating works of our country.
This study is expected to base on making shape of works, by
regarding local characteristics of our country.


This paper expresses the principle of back surplus values of man's wear from the angle of human engineering and sums up the single variable linear regression between back surplus values and bust with draped pattern. On the base of European back bodice suit pattern, we do quantitative analysis on back bodice suit pattern in our country and make it more optimized. In this way, We simplify the procedure of manufacturing and make it more effective.


Photodynamic treatment with methyl aminolevulinate (MAL‐PDT) is considered an effective and highly recommended treatment for Bowen's disease. However, its long‐term efficacy remains to be established, as significant differences have been reported in this respect.


This study examined the longitudinal stability and dynamics of group membership within the Greenspoon and Sakflofske's dual-factor model of mental health. This expanded model incorporates information about subjective well-being (SWB), in addition to psychopathological symptoms, to better identify the mental health status and current functioning of youths. Participants included 730 seventh- and eighth-grade U.S. middle school students. Four groups of students were identified: flourishing (i.e., high SWB and low psychopathology), vulnerable (i.e., low SWB and low psychopathology), symptomatic but content (i.e., high SWB and high psychopathology), and troubled (i.e., low SWB and high psychopathology). Analyses of stability of group membership revealed varying levels of stability, with flourishing students demonstrating the highest stability. Analyses also revealed that social support variables yielded meaningful predictions of changes in group membership. Implications for professional practice are discussed.


Lasers are being used to drive spherical implosions either directly of with generated xrays with the goal of obtaining fusion in the laboratory. Pulsed power can drive implosions with much higher efficiency, but with lower implosion velocities and with cylindrical rather than spherical convergence. MagLIF [S.A. Slutz et al., Phys. Plasmas 17, 056303, 2010] is a concept that uses fuel magnetization and preheat of the fusion fuel to allow these relatively slow cylindrical implosions to achieve fusion conditions. MagLIF experiments on the Z Accelerator at Sandia National Laboratories [M.R. Gomez et al. Phys. Rev. Lett. 113, 155003 (2014)] have produced significant fusion yields with only 18 MA drive. It has been shown numerically [S.A. Slutz and R.A. Vesey, Phys. Rev. Lett.,108, 025003 (2012)] that MagLIF could provide large yields (> 1 GJ) and large gains (~1000) when driven by currents exceeding 60 MA. New pulsed-power machines based on Linear Transformer Driver (LTD) technology [W.A. Stygar et al., submitted to Phys. Rev. ST Accel. Beams] could provide such currents. The basic physical principles of MagLIF and the experimental results obtained so far will be reviewed. Simulations of MagLIF on future LTD machines will be presented.


The BIM paradigm, supplied by appropriate standards like IFC, became unavoidable in recent construction projects. Several applications (e.g. indoor navigation, energy analysis ...) find in it a source of information on which they can rely. However, practices reveal that BIM models are not always directly reliable for applications and the latter have to ensure the validity of the data by their own. In the case of indoor navigation, the calculations will highly rely on the IfcSpace objects describing the rooms, in addition to their spatial relationships with their surrounding components. Unfortunately, it is common to face IFC models in which IfcSpace objects contain wrong geometric and topological description. In this paper, the authors discuss the issues related to BIM models validation for indoor navigation. Furthermore, they present a method to generate valid indoor spaces in IFC models. The approach relies on the structural components of the building (walls, slabs, etc.) and uses topological operations, supported by the combinatorial map data structure, to produce watertight space volumes.


Objective To discuss the diagnosis and treatment of penetrating heart trauma.Methods We retrospectively analized the clinical data of 21 patients with penetrating heart trauma in the latest 11 years.Results All the 21 patients were performed the urgent operation.One patient had cardiac tamponade after the operation of mending myocardium because the pericardium window was too small,and it was not effective to puncture to put a tube for drainage.After nine days of the operation the patient was operated again to resect more pericaidium to drain,and was cured.Another patient had psychiatric symptom after eleven days of the operation.Conclusion The patients with open chest trauma can be diagnosed penetrating heart trauma if he has Beck Triad Sings with systolic pressure decreasing,pulse pressure reducing and central venous pressure increasing,and has echocardiography.The urgent operation of opening chest is the only one effective treatment to reduce the mortality.


The purpose of this study was to study carcass characteristics of swamp buffalo in Pandeglang. A total of 93 samples buffalo from abattoir in the district of Labuan, Pandeglang district, Banten Province. Carcass parameters include slaughter weight, carcass weight, percentage of carcass weight, back fat thickness and rib eye area. Relationship between age and carcass quality of buffalo were analyzed by using the general linear model approach. Age was grouped into I ( 4 years). The results showed that the slaughter weight and carcass weight were influenced by age (P < 0.01) in both sexes buffalo. Influence of age on back fat thickness was found in female buffalo group (P < 0.01). Variables of carcass percentage and rib eye area musle was not affected by age in both sexes. Correlation analysis on carcass quality variables indicate that the slaughter weight positively correlated with carcass weight (0.89) and back fat thickness (0.47). Carcass weight correlated positively with back fat thickness (0.65) and rib eye area (0.22). Positive correlation was also found between the thickness of back fat with a large rib eye area (0.27).


To update a bibliography published earlier by Standing, et al. (1972) a detailed literature search was made. This effort yielded 703 substantial references concerning picture-memory studies listed in three different sections of this paper, that is, one for published papers, one for dissertations, and one for reviews. This updated bibliography covers the period from 1973 through mid-1984. In addition to this updated bibliography, an account of conspicuous trends which reflected the entire set of references in this bibliography and some comments or evaluations of these references were given.


Abstract Cake cutting is a classic fair division problem, with the cake serving as a metaphor for a heterogeneous divisible resource. Recently, it was shown that for any number of players with arbitrary preferences over a cake, it is possible to partition the players into groups of any desired size and divide the cake among the groups so that each group receives a single contiguous piece and every player is envy-free. For two groups, we characterize the group sizes for which such an assignment can be computed by a finite algorithm, showing that the task is possible exactly when one of the groups is a singleton. We also establish an analogous existence result for chore division, and show that the result does not hold for a mixed cake.


Force field-based and ab initio molecular dynamics simulations are combined with impedance spectroscopy experiments to reveal the high proton conduction performance of a three-dimensional titanium phosphate TiIVTiIV(HPO4)4 under humidity and further elucidate the microscopic mechanism at the origin of the proton transport throughout the porosity of this solid. The molecular simulations revealed that the POH groups in the structure act as a proton source, and the proton is transported from one pore to another through the hydrogen bond network formed by water molecules and the bridging O of the solid. Propitiously, besides its superprotonic behavior with a conductivity of 1.2 × 10–3 S cm–1 at room temperature and 95% relative humidity, this material is one of the best porous solids reported to date in terms of efficiency for proton transfer with a resulting activation energy (0.13 eV) as low as that reported for Nafion commercially used as electrolyte membrane in fuel cells. Furthermore, this solid shows a ...


Hydrogen has evolved as the most clean and sustainable fuel, produced directly from naturally abundant water resources. Generation of hydrogen by electrochemical or photoelectrochemical splitting of water have been conceived as the most effective method for the hydrogen production. Herein, we first report a robust solid metal-thiolate framework (MTF-1) by hydrothermal crystallization of the reaction mixture consisting of 1,3,5-triazine-2,4,6-trithioltrisodium salt and Cu(II) under mild synthesis conditions. The material was characterized by PXRD, HRTEM, SEM, XPS, UV-visible spectroscopy. MTF-1 has been explored as efficient catalyst for electrochemical and photoelectrochemical hydrogen evolution reaction (HER) via water splitting reactions. MTF-1 showed onset potential 0.045 V RHE and η (@10 mA cm -2 ) at 0.096 V RHE . The electrochemical surface area (ECSA) of MTF-1 was found to be 509 m 2 g -1 . The photo current density at pH 5.0 was found to be 0.487 mA cm -2 at 0.6 V RHE . The feasibility of the reaction pathway is correlated from the density function theory (DFT) study, which suggested the complete downhill energetics indicating spontaneous electrochemical hydrogen generation in the acidic medium.


Cs2Hg3M2S8 (M ) Ge, Sn) were synthesized in 70% and 65% yields by reacting HgS, and Sn or Ge, in molten Cs2Sx at 520 °C. Rb2Hg3Sn2S8 and Rb2Hg3Ge2S8 were synthesized in 42% and 73% yield by reacting the same reagents in molten Rb2Sx at 350 °C. Cs2Hg3M2S8 crystallize in the triclinic space group P1 h .C s 2Hg3Sn2S8: a ) 7.878(2) A, b ) 9.157(3) A, c ) 6.803(2) A, R) 92.96(2)°, ' ) 109.45(2)°, A ) 107.81(2)°, V ) 434.1(2) A 3 , and Dcalc ) 5.207 g/cm 3 . The unit cell of isostructural Cs2Hg3Ge2S8 is a ) 7.808(2) A, b ) 9.164(2) A, c ) 6.612(2) A, R) 92.02(2)°, ' ) 108.65(2)°g, A ) 108.10(2)°, and V ) 419.9(2) A 3 .R b 2Hg3M2S8 crystallize in the monoclinic space group P21/c ,R b2Hg3Sn2S8: a ) 10.132(2) A, b ) 6.540(2) A, c ) 13.434(2) A, ' ) 97.93(1)°, V ) 881.7(6) A 3 , and Dcalc ) 4.770 g/cm 3 . The unit cell of isostructural Rb2Hg3Ge2S8 is a ) 9.938 (3) A, b ) 6.352 (2) A, c ) 13.117 (3) A, ' ) 97.33 (2)°, and V ) 821.3 (4) A 3 . The structure of Cs2Hg3M2S8 consists of [Hg3M2S8] 2layers separated by Cs + cations. The layers contain tetrahedral Sn 4+ or Ge 4+ centers and two types of Hg 2+ , two coordinate linear and three-coordinate pseudotrigonal centers. The structure of Rb2Hg3M2S8consists of a 3-dimensional [Hg3M2S8] 2- framework with Rb + cations located within channels of the structure. This structure also contains tetrahedral Sn 4+ or Ge 4+ centers and two types of Hg 2+ , the two-coordinate linear type and a four-coordinate "seesaw" geometry. Optical band gaps, determined from single-crystal UV/vis spectroscopy, range from 2.52 eV in the tin-based compounds to 2.89 eV in the germanium-based analogues. Cs2Hg3M2S8 become glasses upon melting. Infrared and Raman spectroscopic characterization of the glasses are reported.


This paper examines whether the Danish management system achieves welfare maximisation. For cod in the North Sea, Skagerrak, and Kattegat, rations are used. It is shown that rations raise substantial information requirements and that the existing allocation of rations is inoptimal. In addition, a linear programming model is used to show that there is considerable overcapacity in the Danish trawler fleet in the Baltic Sea. Danish fisheries managers have access to an extensive data set, and with the available information it would be possible to secure a welfare optimum.


Abstract Objectives. The aim of this study was to retrospectively evaluate three risk scoring methods in predicting outcome after elective endovascular repair of an abdominal aortic aneurysm. Design. A Zenith stent graft was employed in 205 patients during years 2001–2005. Results. The 30-day postoperative mortality rate was 2.9%. Receiver operating characteristics (ROC) curve analysis showed that the Glasgow aneurysm score (GAS) (AUC: 0.843, p=0.004) and the Giles' score (AUC 0.815, p=0.009) had a rather large area under the curve in predicting 30-day mortality rate. The modified Leiden score was much less accurate (AUC: 0.594). The best cut-off value for the GAS in predicting 30-day mortality was 90 (0.6% vs. 17.9%, p<0.0001). Patients with a GAS ≥ 90 had a 4-year survival rate of 56.8%, whereas it was 78.5% among those with a lower GAS (p = 0.001).The best cut-off value for the Giles' score was 11 (1.3% vs. 8.3%, p<0.0001). Patients with a Giles' score ≥ 11 had a 4-year survival rate of 63.9%, whereas it was 79.0% among those with a lower score (p = 0.016). Conclusions. The GAS and Giles' risk scoring methods are good predictors of poor immediate and late outcome after EVAR.


In Reply. —Dr Small has suggested that the conclusion that our simple educational intervention increased the completion of durable power of attorney for health care forms is erroneous. In fact, in this randomized, controlled trial, 18.5% of the subjects in the experimental group completed a durable power of attorney for health care form following the receipt of the intervention materials, compared with 0.4% in the control group ( P Small states that the baseline completion rate


s : Aim of this research is to find out Emotional maturity among students so investigator selected two groups, on is, Home Residential student and other is Hostel College students, both groups have 140 students. In each group has 70 students from hostel college students. Data were collected from V.V. Nagar. Emotional maturity scale by Roma pal (1988) was used for data collection. 2×2 factorial design was used and data were analysised by ANOVA test. Results showel, that there is no significant difference in He Residential and Hostel college students. There is no significant interaction effect in Emotional maturity between residence and sex in college students. The boy's are more mature than the girls's.


A real-time hybrid test of a 3 story-3 bay reinforced concrete frame which is divided into numerical and physical substructure models under uniaxial earthquake excitation was run using a fixed iteration implicit HHT time integration method. The first story inner non-ductile column was selected as the physical substructure model, and uniaxial earthquake excitation was applied to the numerical model until the specimen failed due to severe damage. A finite-element analysis program, Mercury, was newly developed and optimized for a real-time hybrid test. The drift ratio based on the top horizontal displacement of the physical substructure model was compared with the result of a numerical simulation by OpenSees and the result of a shaking table test. The experiment in this paper is one of the most complex real-time hybrid tests, and the description of the hardware, algorithm and models is presented in detail. If there is an improvement in the numerical model, the evaluation of the tangent stiffness matrix of the physical substructure model in the finite element analysis program and better software to reduce the computational time of the element state determination for the force-based beam-column element, then the comparison with the results of the real-time hybrid test and the shaking table test deserves to make a recommendation. In addition, for the goal of a "Numerical simulation of the complex structures under dynamic loading", the real time hybrid test has enough merit as an alternative to dynamic experiments of large and complex structures.


Objective Self-management of chronic diseases is regarded as dynamic experience which is always evolving and that requires constant adjustment. As unexpected and new shifts in diseases occur, patients tend to abandon acquired behaviours calling into question their sustainability over time. Developing a daily self-management routine as a response to lifestyle changes is considered to facilitate self-management performance. However, fitting self-management recommendations in one's daily life activities is a constant challenge. In this review, we describe the performance of self-management routines within daily settings in people living with chronic conditions with the aim of identifying factors that challenge its integration in daily life. Design Scoping review. Data sources We searched PubMed, Web of Science, CINAHL and PsycINFO on February 2022. Eligibility criteria We included qualitative studies on self-management experience, in English, with adult participants, original and peer-reviewed, and depicting the performance of self-management activities in one's own environment. Data extraction and synthesis Two reviewers independently screened titles and abstracts. After agreement, one reviewer screened the full text of relevant articles and extracted the data. The data were synthesised and analysed thematically. PRISMA Extension for Scoping Reviews checklist was used for reporting the steps. Results Twenty-two studies were included. The thematic analysis brought up two overreaching themes. The first one is the Environment support with three subthemes: family and cultural norms; health professionals and guiding communication; and society and disease perceptions. The second theme is comprehension gap with two subthemes: reading the body and applying information. Conclusions The integration of self-management requirements in a daily routine is affected by the patients' inability to apply disease knowledge in different context and by the challenge of understanding body symptoms and predicting body reactions in advance.


In October 2015, the Auditing Standards Board (ASB) issued SAS No. 130, An Audit of Internal Control Over Financial Reporting That Is Integrated With an Audit of Financial Statements (sec. 940), which withdraws AT section 501. SAS No. 130 is effective for integrated audits for periods ending on or after December 15, 2016, at which time the content of this section will be removed. The ASB concluded that, because engagements performed under AT section 501 are required to be integrated with an audit of financial statements, it would be appropriate to move the content of this section from the attestation standards into generally accepted auditing standards.


To one or more users is a system that provides a product annotations in the video. The system receives a video from a user, the video includes a plurality of video frames. The system extracts a plurality of key frames from a video, to generate a visual representation of the key frames. The system, a visual representation of the key frames as compared to the plurality of product visual signatures, where each visual signature identifies the product. Based on a comparison of the visual representation and the product visual signatures of key frames, the system key frame, determines whether to include the product identified by the visual signature of the product. A plurality to generate a plurality of product visual signatures, the system collects a plurality of training images including a plurality of specialized product image obtained from specialty products repository, each specialized product image, obtained from a plurality of web resources associated with the product image.


Methyl-3-(phenylmethyl)-benzeneacetaldehyde was prepared from 3-benzylacetophenone by condensation, hydrolysis and decarboxylation successively in "one pot". The synthetic method was succinct and effective with 82% oveall yield. The title compound is a key intermediate of ketoprofen.


Ground rubber tire (GRT) is a particulate vulcanizate consisting mainly of rubber hydrocarbon and fillers. Rubber hydrocarbon of GRT (rGRT) has been used as a partial substitute for EPDM rubber in a dynamically vulcanized EPDM/acrylic-modified HDPE (A-HDPE) blend. The blends with higher rubber content show poor processability and physical properties, while the compositions with higher plastic content behave like toughened plastics. However, the 60:40 rubber/plastic blend was found to behave as a thermoplastic elastomer, and it was observed that 50% of EPDM can be replaced by rGRT without deterioration in properties.


THE PURPOSE of this review is to investigate the relative merits of different test objects and procedures used to measure visual acuity, with particular emphasis on their suitability as selection tests for industry, the military services, etc., and as screening tests for the detection of errors of refraction or other visual defects. Adoption of a standard procedure for the measurement of individual differences in acuity which gives valid and precise measures and is at the same time simple and practical requires consideration of the following points: (1) selection of the most suitable type of test object; (2) specification of the range and gradation of the sizes of test object required, and (3) standardization of the brightness of test object and background and of other variable factors in the test procedure. RELATIVE MERITS OF DIFFERENT TYPES OF TEST OBJECTS In an excellent review Cowan


Accurate cost information is the most pivotal factor influenced the pricing of logsitics services,but,the traditional costing approach based on product amounts does not suit the costing and pricing demands of logistics services for logistics enterprises.According to the activity-based costing theory,the rationale application of the activity-based costing to costing logistics companies was discussed.According to the process and characteristics of the logistics activities,a costing and pricing decision model of logistics projects based on the activity-based costing for logistics enterprises was constructed,which could deduce the price interval of logistics projects and provide the decision support of quoting,marketing,competing for logistics enterprises.


According to the analysis of the fishing accident statistics during the past decade from Analysis report of China fishery vessel safety(1999-2008),vessel crew is a high risk occupation.One hundred and sixty of every 100,000 fishing crews died in our country,the death rate of which is two times more than that of miners'.Major reasons in these vessel accidents include:crashing accidents between fishery vessels and fishery vessel or other vessels(60.1%),death rate after falling into waters accounts for 46% of the total death,irregular operations caused 58% of fishermen's injury and disability,such as hauling machine accident or breaking down,entwined by fishing nets.There are some key risk points in these accidents,including irregular navigation and operation,backward facilities used on board,unreasonable safety measures,as well as a large number of inferior safety and rescue equipments used.Countermeasures and recommendations were put forward in the paper regarding how to reduce the accidents,which could provide reference for management authorities in developing related policies.


Computers have thus far been applied in medicine most effectively in situations where a standard mechanism already exists for dealing with the data: in the accounting problems of administrative work; in sorting and printing out the results of laboratory tests; and in conventional types of mathematical calculation performed during research or other activities. Despite these obvious and desirable successes, computers have not yet had an important impact on the more inherently clinical features of medical strategy and tactics. The intellectual qualities of scientific practice in clinical medicine do not appear to have been significantly affected by the many theoretical models and grandiose systems proposed during the recent exuberance of "computers in medicine."