Abstract Background The questionnaire "Measurement of Health Literacy Among Adolescents Questionnaire" (MOHLAA-Q) was developed and validated in a multi-stage process to measure generic health literacy among 14- to 17-year-olds. The MOHLAA-Q combines subjective and objective measurements, consisting of four scales. The instrument was applied to explore associations between generic health literacy and different health behaviors among adolescents in Germany. The data should contribute to the age-appropriate development of health promotion interventions. Methods We carried out a nationwide cross-sectional online survey with 1,235 adolescents aged 14-17 years in Germany in 2019. Data on generic health literacy were collected using the four scales of the MOHLAA-Q and data on health behaviors were collected using single established single-item questions on sports, diet, alcohol consumption, and smoking. Bivariate and multiple analyses were performed for investigating associations between generic health literacy and health behaviors, adjusted for age, gender, education and self-efficacy. Results Not consuming fruit and vegetables daily was associated with lower health literacy levels in all examined scales. Doing no sports as well as smoking showed positive associations with low levels in "health-related communication and interaction skills" and "attitudes toward one's own health and health information". No associations were found between risky alcohol consumption and health literacy. Conclusions The results indicate that strengthening health literacy should be part of health promotion activities for increasing physical activity and healthy diet among adolescents. The MOHLAA-Q allows us to identify which specific dimensions of health literacy might be addressed in order to promote different health behaviors.


In this paper, the development history of the clarinet and the structure of the clarinet are summarized. Then, from the aspects of the performance of the clarinet, the teaching method is explained by the type, tone, pronunciation, spit, hand and transit of the clarinet. In the teaching of students prone to the situation to analyze and solve, and playing on the method of teaching some of the views; on the psychological also carried out a brief overview, combined with the above, on the teaching methods of teaching, conducted some discussion ; Playing not only have skills, but also music, for the performance of the works and playing style, through the clarinet each period of representative composers and works for a brief analysis of the style of the song and there are some music on the Playing, summed up from the classical period to the century, the characteristics of various periods of music and style, so as to how the players to form their own style of play to discuss.


These lines of efficient, high-power amplifiers cover frequency ranges as broad as 10 MHz to 26.5 GHz in support of emerging broadband-communications applications.


Characidae is one of the largest fish families of the Neotropical region, and presenting a pronounced morphological variability, certainly does not constitute a monophyletic group. The cytogenetical data also show a large chromosomal variation and can provide important information for a better understanding of the relationships between the species of this group. 18S and 5S rDNA probes were used in the present study for the chromosomal mapping in different Characidae species from the Sao Francisco River (Astyanax lacustris, Astyanax scabripinnis, Hasemania nana, Piabina argentea, Orthospinus franciscensis, Serrapinnus heterodon, Serrapinnus piaba and Myleus micans) and Alto Parana (Astyanax altiparanae) basins. Species with a single pair of chromosomes bearing the nucleolar organizing regions (NORs) were identified, as well as species with multiple NORs, up to a maximum of seven 18S rDNA sites. The number of 5S rDNA site was also not constant, varying from two to eight. The mapping of the ribosomal genes was useful for the characterization and differentiation of the analyzed species.


Commercial applications of Li-ion batteries for the electro mobility and stationary storage require high energy density, high rate capability and long cycle life of the battery. In this paper we have shown the improvement in energy density and rate capability of LiFePO4 composite cathodes by partially replacing conventional binders with poly-o-methoxyaniline (POMA) and tosylate doped poly(3,4-ethylenedioxythiophene) (PEDOT:p-Tos). Due to different redox properties of the used conducting polymers, POMA specifically improves the capacity to 14% as compared to conventional polyvinylidene difluoride (PVDF) and in case of PEDOT:p-Tos 83% capacity is retained at 5 C charging rate.


PREMISE OF THE STUDY
Cryptic species are superficially morphologically indistinguishable and therefore erroneously classified under one single name. The identification and delimitation of these species is usually a difficult task. The main aim of this study is to provide an inclusive methodology that combines standard and new tools to allow accurate identification of cryptic species. We used Erysimum nervosum s.l. as a model system.

METHODS
Four populations belonging to E. nervosum s.l. were sampled at their two distribution ranges in Morocco (the Atlas Mountains and the Rif Mountains). Fifteen individuals per population were collected to assess standard taxonomic traits. Additionally, corolla color and shape were quantified in 30 individuals per population using spectrophotometry and geometric morphometrics, respectively. Finally, we collected tissue samples from each population per species to study the phylogenetic relationships among them.

KEY RESULTS
Using the standard taxonomic traits, we could not distinguish the four populations. Nonetheless, there were differences in corolla color and shape between plants from the two mountain ranges. The population differentiation based on quantitative morphological differences were confirmed and supported by the phylogenetic relationships obtained for these populations and the rest of the Moroccan Erysimum species.

CONCLUSIONS
The joint use of the results obtained from standard taxonomic traits, quantitative analyses of plant phenotype, and molecular data suggests the occurrence of two species within E. nervosum s.l. in Morocco, one located in the Atlas Mountains (E. nervosum s.s.) and the other in the Rif Mountains (E. riphaeanum sp. nov.). Consequently, we suggest that combining quantitative and molecular approaches with standard taxonomy greatly benefits the identification of cryptic species.


Theorem 1.2. If all non-identity elements of G have the same order, this order is a prime p and |G| is a power of p. Proof. If |G| has two prime factors, say p and q, then G contains elements of orders p and q by Cauchy, which contradicts the hypothesis. Thus |G| has only one prime factor, say |G| = pm for a prime p. The orders of a non-identity element could be {p, p2, . . . , pm}. However, by Cauchy some g ∈ G has order p, so the hypothesis tells us every non-identity element of G has order p.


Discontinuity of structural-plane's appearance is a complex research object;however,it has important an influence to the mechanical properties.At the present time,the study of incompletely backfilling of structural-plane is very poor.The adhesive friction theory is applied to research the changing course of structural plane,which is based on the analysis of incompletely backfilling.


An autonomous mobile robot should find feasible trajectories in order to avoid collisions with obstacles in its environment. This ability to plan collision-free trajectories requires two major aspects: modulation and generation of trajectories. This is especially important if temporal stabilization of the generated trajectories is considered. Temporal stabilization means to conform to the planned movement time, in spite of diversified environmental conditions or perturbations. This timing problem applied for wheeled vehicles has not been addressed in most current robotic systems. Herein, we extend our previous work by integrating an architecture able to generate timed trajectories for a wheeled mobile robot, whose goal is to reach a target location within a specified time, independently of the world complexity.


Finding correspondences between different ontologies is a crucial task in the Semantic Web. Ontology matching tools are capable of solving that task in an automated manner, some even dealing with ontologies in different natural languages. Most state of the art matching tools use internal element and structure based techniques, while the use of large-scale external knowledge resources, especially internet resources, is still rare. In this paper, we introduce WikiMatch, a matching tool that exploits Wikipedia as an external knowledge source. We show that using Wikipedia is a feasible way of performing ontology matching, especially if different natural languages are involved.


Shearlet Transform (ST) is one of the most effective approaches for light field reconstruction from Sparsely-Sampled Light Fields (SSLFs). This demo paper presents a comprehensive implementation of ST for light field reconstruction using one of the most popular machine learning libraries, i.e. Tensor Flow. The flexible architecture of TensorFlow allows for the easy deployment of ST across different platforms (CPUs, GPUs, TPUs) running varying operating systems with high efficiency and accuracy.


The use of lean manufacturing principles has grown significantly in recent years. Although these principles make use of many Industrial Engineering methods, there is still limited coverage of lean manufacturing in many Industrial Engineering programs. This may be due to reluctance to add additional courses to existing degree requirements, or a difficulty in bringing together lean concepts that are often scattered among existing courses in the curriculum. To integrate lean principles into the Industrial and Systems Engineering curriculum at Ohio University, a laboratory course was developed. The course integrated methods taught in other ISE courses and demonstrated how these methods related the concept of a lean system. The laboratory approach was taken to enable students to gain hands-on experience in lean principles. The laboratory course met one day a week, which also made fitting the course into their schedules easier for the students. This paper provides an overview of the activities that were conducted in the laboratory sessions to demonstrate lean principles. The paper also discusses the supporting materials, including introductory lectures and out-of-class work. Observations from the instructor of the course and the students participating in it are also included.


The paper analyses the SVPWM control schema of three-phase inverter employing two phase connection mode applied to Brushless DC motor (BLDC) drive with a view to reduce torque ripple is proposed. The current ripple, created due to the stator winding inductance, leads to generation of ripple in the torque and prevents the usage of BLDC motor in a precise servo drive system. SVPWM techniques enjoy an assortment of advantages such as high output quality and less THD. Also a current controlled technique for BLDC motor drives is used. The paper includes MATLAB/ SIMULINK results of conventional hysteresis current PWM and the proposed SVPWM approach. The comparison of simulation results reveals that the SVPWM technique is effective in reducing the torque ripple and THD of current. This control method improves the system performance thus making it suitable for immense applications employing electromechanical actuators.


The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (≥80) predicts progression of renal disease in patients without renal artery stenosis. In 162 patients newly diagnosed with renal disease, the resistance index (1−[enddiastolic velocity/maximum systolic velocity]*100) was measured in segmental arteries of both kidneys. Creatinine clearance was measured at baseline, at 3, 6, and 12 months, and then at yearly intervals thereafter (mean follow-up 3±1.4 years). The combined endpoint was a decrease of creatinine clearance by ≥50%, end-stage renal disease with replacement therapy, or death. Twenty-five patients (15%) had a renal resistance index value ≥80 at baseline. Nineteen (76%) had a decline in renal function; 16 (64%) progressed to dialysis, and 6 (24%) died. In comparison, in patients with renal resistance index values <80, 13 (9%) had a decline in renal function, only 7 (5%) became dialysis-dependent, and 2 (1%) died (P <0.001). In a multivariate regression analysis, only proteinuria and resistance index were independent predictors of declining renal function. A renal resistance index value of ≥80 reliably identifies patients at risk for progressive renal disease.


Research on the mechanism of injury-induced axonal degeneration (Wallerian degeneration) revealed that axonal degeneration is an active process involving transcriptional regulations and enzymatic reactions. Axonal degeneration is observed as part of the pathology in many neurological disorders, including neurodegenerative disorders, and causes key symptoms. Subcellular reactions regulating axonal degeneration are independent from those for apoptosis, in principle, and therefore, prevention of axonal degeneration may constitute an important therapeutic strategy against neurodegenerative disorders. We have previously shown that ZNRF1, a ubiquitin ligase, regulates stability of microtubules constituting cytoskeletal structure in axons via regulating degradation of AKT and thereby controlling its downstream phosphorylation reaction cascade. We also found that the phosphorylation cascade also promotes autophagy in degenerating axons. In this symposium presentation, we will summarize our findings on the mechanism of ZNRF1-dependent regulation of axonal degeneration. Symposium17


Scientific applications need to be moved among supercomputers, such as Tianhe-2 and TSUBAME 2.5. OpenACC provides a directive-based approach for a single source code base with function portability across different accelerators used in the supercomputers. However, the performance portability is not guaranteed by the OpenACC standard. Therefore, we propose a systematic optimization method, instead of auto-tuning by compliers, to achieve reasonable portable performance with minor code modifications. With this method, we evaluate the four kernels from Rodin a benchmark suite and one mini-application Hydro on our hybrid "CPU+GPU+MIC" supercomputer À with the CAPS and PGI compilers. We analyze Parallel Thread Execution (PTX) codes to further understand the performance portability, and find CAPS adopts a different strategy from PGI in thread distribution. The evaluation results show the optimized OpenACC versions can archive a better performance portability ratio than the OpenCL version in some cases. The understanding and the method are valuable for OpenACC application developers to efficiently and correctly use the available OpenACC compilers.


A wheelchair basketball showcase was hosted at a state university in New England. Student surveys revealed that the event had a positive effect on students' views of both individuals with disabilities and adapted sports. Using Allport's (1954) contact theory as a lens, the author demonstrates how the event met the four positive features that Allport believed should be present in order to reduce negative feelings toward another group: (a) equal status between the groups, (b) common goals, (c) intergroup cooperation and (d) the support of authorities. This exploratory study argues that adapted sports can be an effective method to positively impact stereotypical views of people with disabilities. Subscribe to PALAESTRA


normal. It engenders a conviction that whatever is done under its influence is inevitable and right. Jesus is the completely inspired person; He is the temporal manifestation in a human life of the Eternal Word. But His inspiration does not abolish the human being: He remains human, He is fully man, the representative man, the human person after God's image. Thus, in his effort to demonstrate that the orthodox doctrine can be stated in terms of contemporary understanding, Dr. Matthews has failed. For he has jettisoned the doctrine, making Christ a human person with concupiscence. This eclectic view of Christ is confused, inconclusive, and contradictory. It disclaims heresy, but in name only. Such a picture of Christ may please the modern mind; it does not solve the problem of Christ in the twentieth century.


The article analyses the acute problems of the observance of rights to personal liberty and immunity, provided by the Article 5 of the Convention for the Protection of Human Rights and Fundamental Freedoms in the light of the decisions of the European Court of Human Rights in respect of the Russian Federation.


Saurabh Bansal and James S. Dyer study a common problem in the commercial agribusiness market, where farmers have a preference for a farm input such as a seed based on a fit with their geographical...


The present paper aims to analyze the manner in which the parental alienation syndrome (acknowledged as a form of severe psychological abuse against children by the Directive No. 2/2016 for recognition of parental alienation phenomenon) is identified, prevented and treated and by Romanian state authorities.The parental alienation syndrome emerged and started to spread in Romanian society due to the increasing rate of divorce and the larger number of single parent families. According to the definition found in the first article of the Directive no. 2/2016, this form of abuse consists of the "systematic denigration work of one parent by the other parent, with the intention of ali enating the child from the other parent." In the article, we will analyze the legal and deontological duties of officials from the Child Welfare and Protection which operates locally and, also, how the civil courts exercise their active role in solving the cases in which is claimed the existence of this form of severe psychological abuse. We will also describe specific cases. From our point of view, the formal recognition ofthe parental alienation is a progress in the actual achievement of the welfare and best interests of children in Romanian society. This matter must be treated seriously as the emotional abuse committed against minors impede their harmonious and balanced development, with dramatic effects on medium and long term.


290 Background: Neutropenic fever is an oncologic emergency associated with high morbidity and mortality, requiring prompt antibiotic initiation. National infectious disease and oncology guidelines do not recommend vancomycin for standard empiric therapy, unless used for certain evidence-based indications. At our institution, we observed inappropriate use of vancomycin for neutropenic fever and implemented an intervention to educate providers regarding appropriate indications. Methods: We conducted a series of educational sessions focused on the evidence-based indications for vancomycin use in neutropenic fever with residents, nurse practitioners, fellows, and attending physicians. We also displayed educational posters in work rooms and patient units. We conducted a retrospective chart review to assess the impact on vancomycin prescribing practices and patient outcomes pre-intervention (9/1/17 - 2/28/18) and post-intervention (3/1/18 - 5/24/18). We used descriptive statistics and chi-square tests to assess differences. Results: Vancomycin was frequently prescribed without an appropriate indication in the pre-intervention period. Both the overall use and the inappropriate use of vancomycin decreased significantly in the post-intervention period (Table 1). There was no significant difference in mean duration of fever (2.7 vs 2.1 days, p = 0.06) or length of stay (30 vs 34 days, p = 0.58) between the pre- and post-intervention groups, respectively, despite the reduction in vancomycin use. Conclusions: Multidisciplinary educational sessions reduced unnecessary vancomycin use as empiric treatment for neutropenic fever without adverse patient outcomes. This is a low resource intervention that can be applied to other healthcare settings. Future work will evaluate the effect on cost.[Table: see text]


Abstract This study quantified the distribution of animals by farm size for portions of the dairy, beef, swine, and poultry sectors using the 2016 Census of Agriculture. Results showed that the distribution of farm sizes and animal populations were skewed or bimodal and varied by livestock type and by province. Thus, the average farm size has little meaning. Recognizing farm size diversity is important for developing effective policies and programs, conducting appropriate research, and developing practices and technologies to support farms of all sizes.


ABSTRACT Hepatitis C virus (HCV) is the only known positive-stranded RNA virus that causes persistent lifelong infections in humans. Accumulation of HCV RNA can be inhibited with alpha interferon (IFN-α) in vivo and in culture cells. We used cell-based assay systems to investigate the mechanisms responsible for the cytokine-induced inhibition of HCV replication. The results showed that IFN-α could suppress the accumulation of viral RNA by a noncytopathic pathway and could also induce apoptosis of virally infected cells in a concentration- and cell line-dependent fashion. Whereas the noncytopathic IFN-α response depended on a functional Jak-STAT signal transduction pathway, it did not appear to require double-stranded RNA-dependent pathways. Moreover, we found that functional proteasomes were required for establishment of the IFN-α response against HCV. Based on the results described in this study we propose a model for the mechanism by which IFN-α therapy suppresses HCV replication in chronic infections by both cytopathic and noncytopathic means.


In this paper, development of a fully synthesizable 32-bit processor based on the open-source RISC-V (RV32I) ISA is presented. This processor is designed for targeting low-cost embedded devices. A RISC-V development and validation framework with assembling tools and automated test suits is also presented in this paper. The resulting processor is a single core, in-order, non-bus based, RISC-V processor with low hardware complexity. The proposed processor is implemented in Verilog HDL and further prototyped on FPGA "Spartan 3E XC3S500E" board. This is found that the maximum operating frequency is 32MHz. The power is estimated to be 7.9mW using Xilinx Power Analyzer.


Although it is widely acknowledged that collocations are both indispensable and problematic for language learners and that they therefore should play an important part in second language teaching, especially at an advanced level, learners' difficulties with collocations have not been investigated in much detail so far. This paper reports on an exploratory study that analyses the use of verb-noun collocations such as take a break or shake one's head by advanced German-speaking learners of English in free written production. First, an attempt is made to define 'collocations' as precisely as possible, and the methodology that has been developed for analysing learner collocations in free production is described. Then, the types of mistakes that the learners make when producing collocations are identified and the influence of the degree of restriction of a combination and of the learners' L1 on the production of collocations is investigated. While the degree of restriction emerges to have some, but comparatively little, impact on the difficulty of combinations for the learners, the learners' L1 turns out to have a degree of influence that goes far beyond what earlier (small-scale) studies have predicted. Finally, the implications of these results for teaching are discussed, most importantly the role of L1-L2 differences.


Introduction: breast cancer is a health problem which makes the education of women necessary for early diagnosis. Objective: to design an educational intervention aimed at raising the preparation on the subject in women from 18 to 60 years of the Family office 12 of the University Polyclinic "Emilio Daudinot Bueno". Method: between November 2017 and October 2018 a prospective study was carried out, of the educational intervention type. The universe was the total number of women included in the age range indicated, and 97 intentionally selected were included in the study. Their level of information on the subject was investigated before and after applying the educational intervention. Results: before the implementation of the designed educational intervention, 50.5% of the women expressed an insufficient level of information regarding the Family office, and this proportion decreased to 21.6% after applying it, which meant a reduction in 57.2% of women with theoretical deficits regarding the issue. The percentage that increased their preparation was 36.9% (p <0.05), which indicated the advantage of implementing the educational intervention that was designed. Conclusions: the educational intervention aimed at the preparation of women regarding breast cancer in the University Polyclinic "Emilio Daudinot Bueno" made it possible to enrich their culture regarding the subject.


Following the end of the last ice age, decelerating global post‐glacial sea level rises submerged the southern North Sea, and along this coast, 63 km of soft glacial deposits are still being rapidly washed away. The collapse of the massive ice sheets covering Britain, Ireland and Fennoscandia was a complex process, with warming after 14.7 ka. Limited glaciation then returned during the Loch Lomond Stadial at the end of the Pleistocene, Doggerland, connecting Britain with the continent, was slowly immersed, becoming a shrinking island which was rapidly submerged after 8 ka. This coincided with the Storegga tsunami which hit what remained of Doggerland's shores and along the coasts of Scotland and Northumberland. Since then, the sea has risen by around 27.5 m. Now it is clear eustatic increases in global sea levels are starting to accelerate once again, we must start adjusting to this reality in the way we manage our coastal infrastructure and try to understand more about how this interacts with naturally dynamic shorelines.


The invention relates to a device for separating a luggage compartment, in particular a convertible, comprising a under a trunk lid (12) retractable roof (11) with a fixed separating element (10) which by means of at least one lever between an upper position for loading of the luggage compartment and a lower position for depositing the hood is adjustable. It is proposed that the separating element (10) from the trunk (13) is removable without tools.


National ownership is the basic principle in discussing issues related to developing countries. It is also a key to the promotion of peace-building in Afghanistan. In considering national ownership, it is important to distinguish the two elements behind the concept – legitimacy and capacity. These two elements are inter-linked and essential for the promotion of national ownership. The national police, being a core function of a state and the public face of the government, are considered a key to national ownership. The examination of the police will give us a useful insight into the question of national ownership. A comparison will be made between Afghanistan and Timor-Leste, which, despite differences in their situations, share many issues relating to developing a national police force. In Timor-Leste, executive police power is being transferred from the United Nations to the Timorese Police. The conditions for such transfer – institutional, operational and administrative readiness – are concerned both with the capacity and the legitimacy of the Timorese police. The case study in Timor-Leste will show the strong linkage between the two elements; the lack of capacity will undermine the legitimacy of the police and the government, while the police will not be able to sustain a credible service if not backed with legitimacy. The situation is more serious in Afghanistan, where the Afghan police service is suffering from a number of serious issues ranging from the shortage of resources and the lack of adequate training to wide spread corruption. The Afghan police's lack of capacity undermines its legitimacy and public mistrust makes its operation more difficult. As the police is a key pillar of national ownership, to strengthen the Afghan national police contributes to the promotion of Afghan national ownership. In view of the deteriorating security situation, serious efforts should be made to strengthen the Afghan police service. At the same time, it is imperative to build up trust with local people by promoting institutional integrity and strengthening servicing activities. There is a need to take a balanced strategic approach linking capacity building to legitimacy. The reform process must be nationally owned. Policy priorities should be set by Afghans and international donors must respect them. The United Nations, with its distinctive strength - impartiality and broad support from the international community, and the United Nations Assistance Mission in Afghanistan, with its broad mandate and extensive network of field offices, could play a meaningful coordinating role in this area.


Using 1‐D SDS‐PAGE, LC‐MS/MS, and MS3, we identified 119 proteins from chicken egg yolk, 86 of which were not identified in yolk previously. Proteins were roughly quantitated by calculating their exponentially modified protein abundance index (emPAI) to classify them as major or minor yolk components, and to estimate their distribution between yolk plasma and yolk granular fraction. The proteins with highest abundance were serum albumin, the vitellogenin cleavage products, apovitellenins, IgY, ovalbumin, and 12 kDa serum protein with cross‐reactivity to β2‐microglobulin. In addition yolk contained many other serum and egg white proteins, the proteases nothepsin and thrombin, numerous protease inhibitors, and antioxidative enzymes, such as superoxide dismutase and glutathione peroxidase. Among the moderately abundant proteins were two α2‐macroglobulin‐like proteins different from egg white α2‐macroglobulin, and the major biotin‐binding protein of yolk. An unexpected identification was that of the eggshell matrix protein ovocleidin‐116, which was previously thought to be eggshell‐specific. The list of chicken egg yolk proteins provided in this report is by far the most comprehensive at present and may serve as a starting point for the characterization of less well‐known yolk proteins.


To meet the requirements of modern marine high resolution seismic exploration where sound source can generate repetitive,stable and specific acoustic emission,plasma seismic source(PSS) for marine high resolution seismic exploration is described which is based on plasma corona discharge in sea water.Intensive shockwaves are produced when electrical energy stored in capacitors is dumped through electrohydraulic discharge.Pulsed power technology,pulsed corona discharge process,dynamics of bubble oscillation and acoustical emissions are theoretically and experimentally studied.Experimental results of power efficiency of power source,bubble dynamics and acoustical emissions are presented and discussed.After 9 years research and development,PSS has been successfully applied in high resolution seismic exploration,showing a good prospect in underwater acoustic applications.Three typical prototypes of PSS with discharge energies of 500 J per pulse,10 kJ per pulse and 50 kJ per pulse have been developed,their parameters and advantages are also presented.


An idiopathic degeneration involving predominantly the photoreceptors of the retina occurs in the elkhound similar to that which has been reported in other breeds of dogs and analogous to that which occurs in mice and men. It is suggested that the term applied to the comparable condition in man, retinitis pigmentosa, is inappropriate. A preferred name is photoreceptive abiotrophy of the retina. Photoreceptive abiotrophy in the present eight cases appeared to be a mendelian recessive trait producing signs at 6–8 months of age consisting of night blindness, narrowing of the retinal vessels and extinction of the electroretinogram. Pathologically it consists of degeneration of the photoreceptive cells and paradoxic obliteration of the retinal capillaries. Electron microscopy reveals disorganization and fragmentation of the outer segments of the rods and cones and pleating of the inner surface of the pigment epithelium, long before any abnormality is detectable by light microscopy. The pathogenesis of photoreceptive abiotrophy is obscure but in the early case here reported no abnormality was detected in diaphorase activity nor in glycogeneogenesis although there was a paucity of glycogen in the retinal glia and an absence of the normal capacity for glycogen synthesis at a later stage.


Objective To explore the value of electroencephalogram and MRI in diagnosis of pediatric mumps meningeal encephalitis.Methods The EEG and MRI of 60 cases who were diagnosed pediatric mumps meningeal encephalitis were retrospectively analysed.Results The positive rate of EEG and MRI in pediatric mumps meningeal encephalitis were 90.0% and 78.3 % respectively ( P < 0.05 ).Conclusion EEG shows higher sensitivity in diagnosis of pediatric mumps meningeal encephalitis than MRI and it is helpful to combinate EEG and MRI.

Key words:
Pediatric Mumps;  Meningeal Encephalitis;  Electroencephalogram;  MRI


[Problem] To provide a power generating device that generates a large electromotive force using an inexpensive and safe magnetic powder and makes it possible to be used in states other than a raised state.
[Solution] A power generating device comprises: a cylindrical body (2) constructed so as to be able to be hermetically sealed; a coil (3) provided on an outer circumferential portion of the cylindrical body (2); and a permanent magnet (4) provided outside the coil (3). A mixture (5) obtained by mixing a magnetic powder (51) with a liquid or another nonmagnetic powder is sealed inside the cylindrical body (2) so that a space is formed therein, and thereby is allowed to move inside the cylindrical body (2), the magnetic powder (51) preferably having a diameter of 10 μm to 100 μm, inclusive, and being not magnetized. Alternatively, as a liquid like this, by using a liquid containing a surface-activating agent and a defoaming agent, the magnetic powder (51) is non-aggregated and allowed to move inside the cylindrical body (2).


The purpose of this study is to examine the effects of nursing emotional labor, role conflict, and reciprocity on turnover intention in comprehensive nursing care wards nurses. 209 nurses working in comprehensive nursing care wards across 13 hospitals in G and M city participated in this study. Data were analyzed descriptive statistics, t-test, one-way ANOVA, Pearson correlation, and hierarchical multiple regression analysis. As a result, the research model explained 52.9%(F=14.458, p<.001) of intention to turnover. The most significant factor affecting turnover intention was emotional labor(β =.311), followed by reciprocity and role conflict. Therefore, it is necessary to devices and guidelines to protect nurses who encounter various situations in the process of emotional labor, and to implement a human resource management system that can maintain friendly and equal relationships.


In recent times the issue of fresh water shortages and salinity contamination of existing water sources has become a serious problem in a number of locations around the world. Hence, developing an environmentally friendly desalination technique is essential. In this work a theoretical model is developed in order to optimize a novel humidification-dehumidification desalination system. A sensitivity analysis was carried out, in order to find the optimum values for air and water flow rates. From this analysis it was found that a maximum of production rate of 1.5 kg/hr.m 2 was achievable, however it was also found that this rate was particularly influenced by the incident radiation, the inlet water temperature and the water flow rate.


The "clastic Devonian" of Tataria was deposited in Middle Devonian and early Frasnian time of the Late Devonian. This section is most complete in the south and southeast parts of the republic, where its thickness reaches 200 m. See figure 1. Present here are deposits of the Eifelian Stage, Starooskol and Mullin Horizons, Givetian Stage, and Pashiy and Kynov Horizons of the Frasnian Stage. The section consists of alternating sand-silt rocks in the lower parts of horizons and silt-clay rocks in the upper parts. Toward the west the Eifelian, Pashiy, and lower part of the Kynov gradually drop out of the section due to erosion. In the extreme west, where thickness of the clastic Devonian does not exceed 25-30 m, the Starooskol and in places also the Mullin are missing from the section.


The material point method – the finite element method formulated in an arbitrary Lagrangian–Eulerian description of motion – is applied to large strain problems of soil mechanics. Two-dimensional, dynamic problems of pile driving (axisymmetry) and retaining wall failure (plane strain) are analysed. The case of non-cohesive models of the soil is analysed – the elastic–plastic and elastic–viscoplastic material models are applied.


FIELD: information technology. SUBSTANCE: device includes steps on which a response from a client machine associated with the user is intercepted in the device deployed in a defined place in the network; a step on which presence of a first advertisement is determined, and further determination of whether the first advertisement is replaceable; a step on which a second advertisement is selected if the first advertisement is replaceable, and a step on which the first advertisement is replaced by the second advertisement such that the second advertisement can be seen when the web-page is displayed on the client machine. If it is determined that the web-page has a replaceable advertisement, the preferred advertisement, which is of more interest to the user, is embedded in the data packets so as to replace the initial advertisement. As a result, the preferred advertisement serves after display of content of the web-page. EFFECT: invention enables faster control of data packets. 10 cl, 15 dwg


This article describes the method used in the computer basic subjects firstly, teacher is the center of the classroom and makes use of some multimedia devices, they emphasis on explaining grammar. This method is not good enough to train students' creativity. It brings forward a new method named conversion in this paper. After application in Visual C++ programming language it finds this method can raise the interest of students and build excellent classroom environment. In fact students make much progress.


The chemical constituents and contents of essential oil from Solidago canadensis L.were analyzed by GC-MS and antifungal activities against six agricultural pathogenic fungi were also assayed.Fifty compounds,constituting about 91.08% of the oil,were identified and the(+)-germacrene D(28.64%),α-pinene(15.08%) and limonene(11.80%) were main components in the oil.The essential oil displayed the significant inhibition on growth of Thanatephorus cucumeris and Rhizoctonia solani and showed medium effect on Botrytis cinerea,but had pretty weak antifungal activity against Alternaria solani,Colletotrichum lindemuthianum and Glanerlla cingulata.


(*) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS patent is extended or adjusted under 35 U.S.C. 154(b) by 93 days. Asbecket al., "Power Amplifier Approaches for High Efficiency and Linearity." RF Technologies for Low Power Wireless Communica (21) Appl. No.: 11/508,989 tions, Chapter 6, 2001. (Continued) (22) Filed: Aug. 24, 2006 Primary Examiner Khanh Van Nguyen (65) Prior Publication Data (74) Attorney, Agent, or Firm—Sterne, Kessler, Goldstein & FOX PL.L.C. US 2007/0247217 A1 Oct. 25, 2007 OX


What can exactly be recognized as the law? This question not quite the same as more ambitious question, "What is law in China", is nevertheless the first question to be addressed by any study of the legal system in the People's Republic of China (the PRC).This article surveys the system of legislation, the forms of legislation and other points, including amendment, promulgation and enforcement, translation, judicial precedent, custom, and the "policy" (_??__??_) of the state or Chinese Comunist Party (CCP) as a source of the law.There are some significant features in the sources of the law of the PRC;1, All of the laws of Guomindang (Chinese Nationalist Party) were repealed before the founding of the PRC;2, Because of this, the policy of the state or CCP has been one of the sources on those ocasions when there is no other existing legislation;3, There are so many different kinds of forms of legislation that the forms which are provided in laws on state organization cannot cover all of them;4, But, in quantity of laws and regulations, there are 36 (37) kinds of the forms which are provided in laws on state organization that cover most of legislation;5, 25 (26) of the 36 (37) are Gongwen (_??__??_), most of which are reports or documents of state administrative authorities;6, There had been no clear rules on promulgation and enforcement before 1987;7, There is still no rule of judicial precedent;8, Custom is recognized as a source of the law or a reference only in certain laws and regulations.


African swine fever (ASF) is known to cause large economic losses to swine producers due to the disease's high infectiousness, swift spread, and high mortality rate. Currently there are no safe and reliable vaccines available for use in swine production facilities. The virus's ability to remain infectious for extended periods of time in the environment, in pork products, and a range of external conditions makes the understanding ASF vectors and transmission routes critical to preventing infection in swine herds. Soft ticks are the main vectors and reservoir hosts for ASF. They facilitate viral replication and can infect pigs over a year after becoming infected. However, there is no current evidence of a direct relationship between soft ticks' occurrence and ASFv spread within Europe and they are environmentally limited within China. The seasonal trend of ASF in Europe, the extended habitats of mosquitoes, and the known ability of mosquitoes to carry a variety of diseases, make it important to better understand if mosquitoes can be ASF vectors. This study investigated the possibility of mosquitoes carrying ASFv in swine farms within China.


We report the case of an 11-year-old girl presenting with a 1.5-year history of swan neck-like deformed joint contractures of both hands. A possible diagnosis was sought in a wide range of rheumatological, metabolic, and neurological disorders. After detailed diagnostic procedures to exclude an organic pathology, steps were taken to establish a psychogenic origin. She showed symptoms that were incongruent with an organic neurological disorder, for example, a paroxysmal fluctuating course, reaction to placebo, and complete remission with psychotherapy and physiotherapy. The psychosomatic evaluation revealed a highly emotional conflict. This bizarre case demonstrates that secondary contractures are by no means an exclusion criterion for a psychogenic dystonia.


Background: A substantial percentage of patients transfused with blood products develop HLA allo-immunization. Although HLA-matched platelets are effective in treating thrombocytopenia for those with HLA antibodies, a significant proportion of patients lack HLA-compatible platelet products resulting in platelet transfusion refractoriness and life-threatening thrombocytopenia. We and others have shown that compliment activation leading to the destruction of platelets bound by HLA allo-antibodies may play a pathophysiologic role in platelet refractoriness. Eculizumab is a monoclonal antibody that binds and inhibits C5 complement, blocking both the classic and alternative pathways of complement. Here we investigated whether treatment with eculizumab could be used as a treatment in HLA allo-immunized patients to overcome platelet transfusion refractoriness. Methods: We conducted a phase II pilot trial (NCT02298933) of eculizumab treatment in 10 subjects who had 1) HLA allo-immunization (detectable HLA class I antibodies), 2) severe thrombocytopenia and 3) platelet transfusion refractoriness. Patients were treated with a single infusion of eculizumab at a dose of 1200mg. Platelet refractoriness was defined as a transfusion corrected platelet count increment (CCI) of 7500/uL at 10-60 minutes together with a CCI>5000/uL 18-24 hours post transfusion. Subjects were taken off study 14 days following eculizumab treatment. Responding patients who developed recurrent platelet refractoriness were eligible to re-enroll on study. All patients were required to receive meningococcal vaccination before eculizumab administration +/- antibiotic prophylaxis to cover N. meningitidis. Results: As of 4/2017, 11 Eculizumab infusions were administered to 10 HLA allo-immunized subjects (median age 39.5 years, range 20-71) with severe thrombocytopenia associated with platelet transfusion refractoriness. Patients had a diagnosis of SAA (n=4), refractory/relapsed AML (n=3); relapsed ALL (n=2) and high risk MDS (n=1). Total complement (CH50) was the most reliable measurement for complement inhibition; CH50 decreased to Remarkably, platelet refractoriness was overcome with eculizumab treatment in patients receiving HLA incompatible platelets; in 4 out of 5 cases where platelet refractoriness was overcome, the administered platelet product given immediately after eculizumab treatment expressed an HLA allele for which an HLA antibody had been detected in the patient9s serum (Table 2) . Resolution of platelet refractoriness resulted in a clinically meaningful reduction in the requirement for platelet transfusions: the median number of platelet transfusion given 2 weeks before and 2 weeks after the eculizumab infusion in responding patients was 9 (range from 3 to 11) and 4 (range from 3 to 5) transfusions respectively. For the non-responders, the median number of platelet transfusions given 2 weeks before and 2 weeks after the eculizumab infusion was 8 (range from 5 to 10) and 9.5 (range from 5 to 15) transfusions respectively. Conclusions: Final data from this pilot trial suggest eculizumab has efficacy in overcoming HLA antibody-associated platelet transfusion refractoriness. Importantly, these data reveal that eculizumab has the ability to overcome platelet transfusion refractoriness in patients with broad HLA allo-immunization in situations where HLA compatible platelets are unavailable. This study establishes proof of principle of the therapeutic role that compliment inhibition can play in overcoming platelet transfusion refractoriness and lays the foundation for a larger multicenter trial to define the overall efficacy of this approach. Disclosures No relevant conflicts of interest to declare.


Abstract New dipeptide–dihydroquinolinone derivatives were successfully synthesised by benzotriazole mediated nucleophilic acyl substitution reaction and their structures were elucidated by spectroscopic and analytic techniques. The carbonic anhydrase (CA, EC 184.108.40.206) inhibitory activity of the new compounds was determined against four human (h) isoforms, hCA I, hCA II, hCA IX and hCA XII. While all compounds showed moderate to good in vitro CA inhibitory properties against hCA IX and hCA XII with inhibition constants in the micromolar level (37.7–86.8 and 2.0–8.6 µM, respectively), they did not show inhibitory activity against hCA I and hCA II up to 100 µM concentration. The antioxidant capacity of the peptide–dihydroquinolinone conjugates was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. Most of the synthesised compounds showed low antioxidant activities compared to the control antioxidant compounds BHA and α-tocopherol.


Holographic optical elements recorded employing an object beam originated at a point can act as image forming systems free from aberrations if the reconstruction and reference beams coincide. However if these beams are tilted, aberrations often appear. In this article, a diffractive optical element free from coma is predesigned and numerically tested.


For thin film solar cells, there is a large gap between the record efficiencies and panel power output. It was found that for a "typical industrial" CIGS cell efficiency of 15.5%, the efficiency drops to 11.7% when it is operating under the circumstances of a monolithically integrated solar panel. Part of this gap is due to limited conductivity and transmittance of the front contact. By application of a metallic grid, the conductivity can be improved by over two order of magnitude at a transmittance loss of only a few percent as was shown experimentally. In addition, modeling was used to quantify the impact of such approach on the power output of monolithically integrated solar panels. This model includes optical and resistive losses, as well as related losses caused by the inhomogeneity of the operating voltage over the surface. Both power output and the different types of losses are mapped out for various cell configurations. Optimization of transparent conductive oxide resistance, cell length, finger width, and finger spacing of grids was performed and led to an efficiency improvement from 11.7% to 13.8% when the front contact is upgraded with a metallic grid consisting of 20 µm wide parallel fingers positioned perpendicular to the interconnect. Further optimization for a wide variety of cell and grid configurations show that for a technically more feasible size of 100 µm wide fingers, the calculated efficiency is still 13.5%. Finally, the power output is mapped out for a large number of configurations as to create an overview and insight in the interdependencies of cell configuration and finger dimensions. Copyright © 2014 John Wiley & Sons, Ltd.


Sui Dynasty established a new kind of official system,and Tang,Five Dynasties inherited it.Althrough changed with time,the administrative centre of official system is three Shengs(省),six Ministries(部)(Ministry of Civil Appointment吏部,Ministry of Revenue户部,Ministry of Rites礼部,Ministry of War兵部,Ministry of Punishment刑部,Ministry of Works 工部),all Courts(寺) and Jians(监).Being the forestry administrative departments,Ministry of Revenue and Ministry of Works were in charge of the decree of forest management and utilization.Sinong Court(司农寺),Jiangzuo Jian(将作监),Shaofu Jian(少府监) and other relative Courts and Jians managed advising people pursuing farming and sericulture,planting bamboo and trees,deforestation,supply of fuel forests,management of landscape and architecture and woodwork technique,and they are the general affairs sections.The latter weren't subordinate to the former,but must obey the former departments' decree.This official system manifested the characteristics of composition dispersed and command concentrated of forestry official system in Sui,Tang and Five Dynasties.


This article, written as a foreword to the hundredth volume of the Law Reports of the Commonwealth (LRC), celebrates the growing success of these law reports published since 1985. Generally appearing in four or five volumes each year, the reports collect some of the main cases, mostly from final courts, decided throughout the Commonwealth of Nations. With the demise of the Privy Council as an institutional link, the courts of the Commonwealth remain connected by the English language, a shared doctrinal and historical tradition, common legal taxonomies and a similar professional culture. The author pays special tribute to the excellent Cumulative Indexes from the 1980s to date; the insightful annual Editorial Reviews which draw attention to grand themes and trends throughout the Commonwealth in the LRCs; the outstanding work of the two foundation general editors Professor James Read and Dr. Peter Slinn; and the publishers Butterworths LexisNexis. In the place of imperial rule there is now a free sharing of knowledge in the law, as befits the free association of the Commonwealth of Nations.


Self trapping exciton state is obtained for an open chain of a PNB polymer with finite length, in the framework of the Baranowski Butterner Voit model. The results shows:an electric field makes notable effects on the charge density, ring torsion angle and bond lenth configuration of the exciton. And it makes the absorption peak of the exciton move to higher energy. While the electric field is stronger than 0.74 MV/cm, the exciton is dissociated into a soliton and an anti soliton, and the single peak of the exciton absorption is splitted into two peaks at 1.1 eV and 1.4 eV, associated with the electron soliton and hole soliton. Based on the results, we attribute the absorption peaks at 1.0 eV and 1.3 eV observed in the polymer to the pair of solitons.


The ever-increasing and diverse user demands as well as the need for uninterrupted access to the medium with minimum latency in dense machine type communication networks, are the key driving forces to a holistic network redesign. In this context, fifth-generation and beyond (5G/B5G) networks, incorporate various advanced physical layer techniques, such as relaying-assisted transmission, aiming to improve network performance hl and extend the coverage area of multicellular orientations. However, the deployment of such techniques in a cellular environment characterized by high interference levels and multi-variate channel representations, leads to increased computational complexity for radio resource management (RRM) tasks. Machine learning (ML), and especially Deep Learning (DL), is proposed as an efficient way to support end-to-end user applications in highly complex environments, since ML/DL models can relax the R hl RM-associated computational burden. In this paper, we consider the joint problem of relay node (RN) placement and selection subject to subcarrier allocation and power management constraints in 5G/B5G hl networks. Various DL-based methods are examined and combined to solve both sub-problems. The performance of these schemes is evaluated for various relaying-assisted transmission approaches, hl either considering known channel state information (CSI) or not. According to the derived results, total system energy efficiency (EE) and spectral efficiency (SE) can be improved by up to 30%, when considering only the DL-based RN placement scheme compared to state-of-the-art non-ML schemes. The deployment of the reinforcement learning (RL) model for RN selection, can improve EE up to 80%, while SE can be improved up to 75%, compared to a system with only DL-enabled RN placement.


It was shown that in ultrafine-grained nanostructured Cu processed by severe plastic
deformation and subjected to cold rolling and annealing, the level and character of Young's
modulus anisotropy is significantly different from values corresponding to cold rolled and
annealed coarse-grained Cu. The crystallographic texture formation processes are investigated
in these states in parallel. The comparative study of the elastic behaviour and
crystallographic texture lets us draw conclusions concerning the leading role of not only
developing crystallographic texture but a specific defect structure of grain boundaries as
well in the formation of unusual elastic properties of ultrafine-grained materials processed
by severe plastic deformation.


Background: Anastomotic leakage (AL) related to colorectal surgery is associated with high morbidity and mortality. Predicting AL remains challenging but may improve outcomes significantly. Serum biomarkers, such as C reactive protein (CRP), white blood (WBC) count and platelets could be useful. Aim: To evaluate the role of CRP, WBC and platelets in postoperative period of colorectal surgery with anastomosis as predictors of AL. Methods: A prospective database including patients undergoing colorectal surgery was developed during a 16-month period. After applying exclusion criteria, 84 patients were eligible. In the postoperative period, daily blood samples were collected to determine CRP, WBC and platelet count until postoperative day 5 or until discharge. Results: Eight patients developed AL (50% of which were major). An association between AL and high CRP was demonstrated on postoperative day 2 with a threshold of 223.7 mg/L. CRP presented an area under the receiver operator curve (AUROC) of 0.7993. White blood count (WBC) and platelet count did not demonstrate any significant difference between groups. Conclusion: CRP is a useful serum biomarker for the early diagnosis of AL after colorectal surgery. Early recognition of AL may lead to better outcomes.


This study compares the efficiency of a non-linear model called artificial neural network with linear autoregressive and random walk models in the one-step-ahead prediction of daily Indian rupee/US dollar exchange rate. We find that neural network and linear autoregressive models outperform random walk model in in-sample and out-of-sample forecasts. The in-sample forecasting of neural network is found to be better than that of linear autoregressive model. As far as out-of-sample forecasting is concerned, the results are mixed and we do not find a "winner" model between neural network and linear autoregressive model. However, neural network is able to improve upon the linear autoregressive model in terms of sign predictions. In addition to this, we also find that the number of input nodes has greater impact on neural network's performance than the number of hidden nodes.


The study comprised 50 patients with West syndrome who were treated at our hospital from January 1975 to January 1990. The ratio of boys to girls was 27:23. The age at onset of infantile spasms (IS) ranged from 2 months to 1 year and 10 months (mean age 6.9 months). The 50 patients were classified into the following four groups: cryptogenic patients receiving 0.025 mg/kg ACTH per day (4 patients) (I-C), symptomatic patients receiving 0.025 mg/kg of ACTH per day (25 patients) (I-S), cryptogenic patients receiving 0.015 mg/kg of ACTH per day ( 5 cases)(II-C), and symptomatic cases receiving 0.015 mg/ kg of ACTH per day (16 cases)(II-S). Children with normal development and no abnormalities on neurological tests and imaging studies at the time of onset were classified under the cryptogenic group, while all the others were symptomatic. Treatment was discontinued depending on the response to treatment or the appearance of side effects. Seizure recurrence was assessed 16 months after the treatment.


This paper concerns the autonomous responsive type light adjustment window (intelligent windows) among smart windows which adjust the light upon receiving environmental energy. More specifically, this is a thermotropic window panel that laminates and seals a new type of highly viscous polymer aqueous solution gel. A conventional thermotropic window panel has never been put to practical use since the reversible change between the colorless, transparent state (water-clear) and translucent scattered state (paper-white) with uniformity was not possible. The change involved phase separation and generated non-uniformity. The author, after fundamental studies of hydrophobic bonding, successfully solved the problem by developing a polymer aqueous solution gel with amphiphatic molecule as the third component in addition to water and water-soluble polymer with hydrophobic radical, based on the molecular spacer concept. In addition, the author established peripheral technologies and succeeded in experimentally fabricating a panel type 'Affinity's Intelligent Window (AIW)' that has attained the level of practical use.


JN this study, Roy Allen explains new uses of money and new financial, trade flows in the global economic system. It is argued that international financial markets absorb an increasing amount of money in order to operate effectively, making it "less" available for non-financial or GDP uses. He also shows, how existing paradigms, e.g. Keynesianism and monetarism, fail, in several ways, to reflect increasingly globalized economic processes and also develops elements of a new methodological approach which better approximates these processes.


CHERNOBYL, UKRAINE-In the 10 years since the world's worst nuclear accident tumed this obscure town's name into a household word, armies of scientists have been trying to figure out exactly what happened inside reactor number 4 of the Chemobyl nuclear power plant on 26 April 1986-and what is likely to happen to the health of the surrounding population as a result. Researchers are confident they know what triggered the accident, and preliminary results from some of the medical studies are trickling in: Aside from a sharp increase in the incidence of childhood thyroid cancer, much ofthe medical news so far is reassuring (see page 357). But for a small band of200 scientists based in a former kindergarten here, an urgent question remains unanswered: What happened to the 190 tons of uranium oxide fuel that originally resided in the destroyed reactor? Estimates of the amounts released into the atmosphere and the tally so far ofthe fuel in the rubble beneath the reactor leave between 10 and 50 tons unaccounted for. Three different scenarios have emerged to explain this discrepancy: Some or all of the missing fuel may have been ejected in the initial explosion, or it may have been spewed out in the subsequent fire, or it may be as yet undiscovered beneath the reactor. Each of these alternatives is based on different views of what occurred in the early stages of the accidenta period of this much-studied event that remains a topic of considerable scientific debate. Figuring out how the accident progressed and where the missing fuel ended up is largely the job of the 200 researchers in this ghost town who belong to the Ukrainian National Academy of Sciences' (UNAS's) Intersectorial Scientific and Technical Center (ISTC). Because most ofthe reactor's monitoring equipment was lost in the two explosions that destroyed reac-


Active noise control is a research area, where both
 acoustic and control related problems influence success of applications. The aim
 of the paper is to address the control aspects. After introducing active noise
 control in general, the fundamental state of the art is presented. The possible
 control techniques are discussed. Premises for the choice of feedforward,
 feedback and combined architectures are summarised. Single-channel and
 multi-channel systems are confronted. Benefits and drawbacks of continuous-time
 and discrete-time approaches are emphasised. Fixed-parameter and adaptive
 control systems are referenced. General control system requirements are
 formulated. Fundamental performance limitations are explained. Various control
 problem formulations including cost functions and constraints are presented for
 an exemplary structure.


When a new system, concept, or tool is proposed in the aviation domain, one concern is the impact that it will have on operator workload. As an experience, workload is difficult to measure in a way that will allow comparison of proposed systems with those already in existence. Chatterji and Sridhar (2001) suggested a method by which airspace parameters can be translated into workload ratings, using a neural network. This approach was employed, and modified to accept input from a non-real time airspace simulation model. The following sections describe the method and pilot test comparing a future airspace concept with a current day baseline in terms of workload levels. The results presented describe a preliminary analysis from using these models with the data from two non-real time model runs.


Customer satisfaction is the perception of customers on the service whether that service has met his needs and expectations. The quality of service, personal demographic and psychological factors, perception of equity and fairness, price, product quality, situational factors, and attributions for service success or failure are the factors that influence the customer satisfaction. This research paper will determine the attributes which influence consumer decision making process while opting for any tax saving instrument or financial instruments like life insurance depending upon its flexibility, reliability of brand, liquidity and many other features. The descriptive survey with the research articles it brings to the fore that the Life insurance has been preferred as depending on the services offered by the insurance companies like number of product, knowledge of customer (via KYC), timely issuance of policies and after-sales services before and after claim. By understanding financial services customer can improve business for companies on the basis of better service received. The insurance firms strive to identify customer requirements and develop strategies that allow them to meet or beat the service level provided by their competitors.


An accurate approach for diagnosis of attention deficit hyperactivity disorder (ADHD) is presented in this paper. The presented technique efficiently classifies three subtypes of ADHD (ADHD-C, ADHD-H, ADHD-I) and typically developing control (TDC) by using only structural magnetic resonance imaging (MRI). The research examines structural MRI of the hippocampus from the ADHD-200 database. Each available MRI has been processed by a region-of-interest (ROI) to build a set of features for further analysis. The presented ADHD diagnostic approach unifies feature selection and classification techniques. The feature selection technique based on the proposed binary-coded genetic algorithm searches for an optimal subset of features extracted from the hippocampus. The classification technique uses a chosen optimal subset of features for accurate classification of three subtypes of ADHD and TDC. In this study, the famous Extreme Learning Machine is used as a classification technique. Experimental results clearly indicate that the presented BCGA-ELM (binary-coded genetic algorithm coupled with Extreme Learning Machine) efficiently classifies TDC and three subtypes of ADHD and outperforms existing techniques.


The invention relates to a wall shuttering for concrete structures comprising a base body, configured as a formwork skin and outer side anchor holes for detachable connection to other wall formwork. It is proposed to arrange the anchor holes with a substantially uniform pitch to each other and to dimension the wall formwork so that the distance between the anchor holes to the outer vertical and / or horizontal limitation of the wall formwork no more than half the grid distance, preferably substantially the half of the grid spacing corresponds.


This LibGuide will help students find books and articles. It also provides information on ALA and MLA citation styles. Information on how to find films and videos


The working principle of drying machine of rotation is introduced,the content of combined construction of CAD system of drying machine of rotation and associated caculation of design,analysis,drafting creation is accounted,fill the blank of CAD system of this type machine,it is compatibility and valuable to application.


The article reveals some results of a sociological study on the features of religious identity of spouses and social practices of children's inclusion in interethnic families (on the example of the Republic of Bashkortostan). This topic is most relevant for multi-ethnic regions, where interfaith marriages are quite common, despite the presence of isolationist attitudes among a part of the population. Marriages between representatives of various religious movements lead to the formation of a special cross-cultural environment of interaction, which requires the spouses to make many decisions, including on the confessional affiliation of children, on the choice of mechanisms for the formation of religious identity. Based on the author's research, the article analyses the state of religious identity of a resident of a multi-ethnic region in a dynamic aspect. Special attention is paid to spouses who are in an interethnic marriage. The author studies variants of religious communications, among which the dominant one is the co-existence of religions in variations from "common / unified religion" to "equality". Most of the families studied are classified as egalitarian and democratic in terms of their power structure and upbringing model. The article provides data on the state of religious identity of children raised in multi-ethnic families. The authors call traditional, psychological and educational motives for introducing children to religion the predominant ones. Based on the presented material, the authors come to the conclusion that there are two most common models of introducing children to religion in interethnic families: passive (indirect) and active religious socialization. The first model is the most popular among residents of large cities, while traditional families choose the second one.


Goldstone-Mode Phonon Dynamics in the Pyrochlore Cd2Re2O7 C. A. Kendziora, I. A. Sergienko, R. Jin, J. He, V. Keppens, B. C. Sales, and D. Mandrus Naval Research Laboratory, Washington, D.C. 20375-6365, USA Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3X7, Canada Condensed Matter Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA Department of Physics and Astronomy, The University of Tennessee, Knoxville, Tennessee 37996, USA Department of Materials Science and Engineering, The University of Tennessee, Knoxville, Tennessee 37996, USA (Received 30 March 2005; published 16 September 2005)


The Amazon River is the world's largest, discharging more water to the ocean than any other river. Study of the world's freshwater resources becomes more significant with increasing awareness of global climate change and its potential effect on those resources and atmospheric forcing. In this work, a reanalysis of the daily discharge and gauge height data for 87 active gauge stations throughout the Amazon River Basin is presented. The data was originally obtained from the web site maintained by ANEEL – Brazilian Electricity Regulatory Agency. We describe the problems encountered in trying to use the original data and the assumptions applied in the reanalysis procedure. The reanalysis consisted of filtering inconsistencies in the comma (decimal) notation, filling in missing data, and replacing inconsistent data values by applying the assumption of a stationary Markov process. The reanalyzed data is available to the community through an anonymous ftp-site.


The competence of integrating circuits within LTCC materials is an added advantage to implement the material in electronic circuits. Since the circuits are buried inside the material, it is not easy to tune the circuit if the required performances are not achieved. Therefore precise knowledge of microwave properties of Low Temperature Co-fired Ceramic (LTCC) materials is crucial before designing the circuit for the efficient design of microwave systems, especially for design of communication filters. Many communication devices operate at low temperatures. In order to implement LTCC at low temperature communication circuits and devices, engineers need precise values of the complex permittivity. The aim of this paper is to characterize LTCC material as a function of temperature at microwave frequencies using a very precise measurement technique, Split Post Dielectric Resonator. DuPont Green Tapes were characterized in the temperature range of 20 K – 300K at a frequency of 9.5 GHz.


Osteoporosis is a condition in which the bones are thinner and more liable to fracture. It is commoner in women and in people over 50. It cannot be cured so the focus is on prevention, which means identifying and addressing risk factors such as obesity, low vitamin D, chronic inflammation and prolonged steroid medication. Chronic urticaria (hives, CU) is an inflammatory condition, so one might expect it to be linked with osteoporosis, but that has never been investigated. If people with CU are indeed more likely to develop osteoporosis, they could be advised about preventative measures. To study this, doctors from Israel identified 11,944 patients diagnosed with CU in a large medical database covering 4.5 million people. A potential difficulty was that people with CU are more likely to be female, obese and to have been treated with systemic steroids, all of which also increase the risk of osteoporosis. Therefore for each CU patient they studied 5 age‐ and sex‐matched control patients (people of the same age and sex but without CU) and their analyses took into account other known risk factors for osteoporosis. During a 16 year period 8.7% of the patients with CU were diagnosed with osteoporosis compared with 6.8% of the controls. They concluded that CU is a small but significant additional risk factor for osteoporosis. An accompanying editorial cautions against basing conclusions on routine health records which may not have all the information required. Nonetheless, doctors treating chronic urticaria might bear in mind the risk of osteoporosis in their patients, and counsel accordingly.


Supplemental Results Ancestral sequence reconstruct ion and capture specif ic i ty Our study is based on a fragment of Doedicurus sp. carapace that contains a small quantity of endogenous DNA (Figure S1a). Given the low percent on-target endogenous DNA in this sample, shotgun Illumina sequencing would have been cost prohibitive. Targeted enrichment, using baits designed on the basis of sequence data from modern species, has been shown to provide an efficient way of retrieving endogeneous genetic material from the DNA extracts of extinct remains [S1]. However, in cases in which the extinct taxon has uncertain phylogenetic affinities, it may be advantageous to use baits designed from ancestral sequences reconstructed in silico from a phylogenetic analysis of modern sequences. Results using these ancestrally reconstructed baits show that our procedure allows for the capture of endogenous mitochondrial reads of extinct Doedicurus with increased specificity when compared to baits designed strictly on modern species genomes (Fig. S2b). As can be seen, the percentage of baits mapping to the assembled Doedicurus mitogenome at different thresholds (allowing from 5% to 40% mismatches) was consistently higher for ancestrally designed baits than it was for baits derived from extant species alone. This is particularly evident for the more stringent mapping thresholds (5% to 20%) in which higher mapping percentages were obtained with baits designed from the ancestral xenarthran mitogenome sequence. For example, when 15% mismatches are allowed between the reads and the Doedicurus mitogenome, 61% of the baits designed from the ancestral xenarthran mitogenome mapped, versus only 6% of the baits designed from the extant Bradypus tridactylus mitogenome. Even though low specificity baits (up to 40% sequence divergence) have been shown to be relatively efficient at capturing target regions [S2], our procedure based on ancestral sequence reconstruction appears to improve the specificity of capture in the case of Doedicurus, which represents a distinct armadillo lineage without close living relatives. As specificity is important in aDNA studies in which target sequences typically represent a minority of sequence data within an extract, the method presented here could potentially prove useful for future aDNA studies.


Concerning the environmental issues, the eco-friendly panel product has been developed by using natural based adhesive to ensure safe product application for human health. In this study, Paraserienthes falcataria veneer and citric acid – starch were used in the manufacturing of plywood. The 30 wt% concentration of citric acid – starch-based adhesive was prepared and it was spread to each veneer with 150 g/m2 of glue spread. The plywood was constructed by 3 layers of veneers. The dimension of each veneer was 30 × 30 × 0.2 (cm). The effect of composition ratio between citric acid (CA) and starch (St) as natural sources of adhesive on delamination and shear strength of the plywood was investigated. The plywood was produced under pressing conditions of 180°C for 10 min with 5 MPa of pressure. The variation of compositions ratio (CA:St) were 90:10, 80:20, 70:30, 60:40, 50:50. The research results showed that the plywood with 50 wt% additional of starch had the lowest delamination and highest shear strength. The shear strength of plywood satisfied Standard National Indonesia (SNI) of plywood for general use. Infrared (IR) spectral analysis demonstrated the presence of ester linkage, indicating that the carboxyl groups of citric acid reacted with the hydroxyl groups of the wood veneer. Therefore, 50:50 of composition ration between CA and St was effective composition ratio in the manufacturing of eco-friendly plywood.


The role of clouds in the climate system, their interaction with radiation, the coupling between aerosols and clouds and the atmospheric branch of the hydrological cycle are recognized as key elements in the climate system by several international consortia, such as the Joint Programming Initiative Connecting Climate Change Knowledge for Europe (JPI Climate) and the Intergovernmental Panel on Climate Change (IPCC). Although these research topics are high on the international research agenda, hardly anything is known about the interaction between clouds, precipitation and aerosols in the Antarctic. This is unfortunate, as the Antarctic ice sheet is expected to become a dominant contributor to sea level rise in the 21 century. Since precipitation is the only source of mass to the ice sheet, and precipitation and cloud processes are closely connected, an improved insight in these processes is essential.


The human placenta once was thrown after the delivery, found to be a very useful organ though it has very short life. With more and new research the old concept about placenta has changed. Now it is well established that health of growing embryo depends on the health of the placenta. To begin with immunology of neonate also depends on transplacental transport. It is well established that the health of the growing embryo depends on the health of the transplacental transport. Normally, IgG can be transported through placenta however, in Covid-19 infected pregnant woman even IgM, which is much bigger molecule than IgG, can also be transported and are found in the embryo.


This case study presents the unusual experience of performing a series of Voluntary Guinea pig – Conscins of the Conscientiogram jointly with my Evolutionary Duo, throughout the 15 months of the Intraconsciential Recycling II (Recin II), part of the Self-conscientiometric Program promoted by the International Association of Interassistantial Conscientiometry (CONSCIUS). It presents the optimizing prophylactic measures of the join experience of the technique, the evolutionary benefits for the duo through the mutual self-exposition and the interassistance dedramatizing the realization of Guinea pig – Conscins by a duo.


Despite earlier expectations that globalization would eradicate the need for geographical space and distance, 'maps matter' today in ways that were unimaginable a mere two decades ago. Technological advances have brought to the fore an entirely new set of methods for representing and interacting with spatial formations, while the ever-increasing mobility of ideas, capital and people has created a world in which urban and regional inequalities are being heightened at an accelerating pace. As a result, the ability of any given place to reap the benefits of global socio-technical flows mainly hinges on the forging of connections that can transcend the limits of its material location. In contrast to the traditional 'topographic' perspective, the territorial extent of economic and political realms is being increasingly conceived though a 'topological' lens: as a set of overlapping reticulations in which the nature and frequency of links among different sites matter more than the physical distances between them.


SUMMARY This study aims to determine pathological findings observed in serologically Mycoplasma gallisepticum (MG) and Mycoplasma synoviae (MS) positive chickens and to compare immunohistochemical, PCR and culture methods for the mycoplasmosis diagnosis. For that, clinical findings were recorded in 120 broiler chickens from commercial poultry farms serologically MG (n = 27) and MS (n = 93) positive with the rapid slide agglutination test. Following necropsy, tissue samples of sinus, trachea, lung, air sac and knee joint were examined using culture, PCR, histological and immunohistochemical (IHC) techniques. Clinical, anatomical and histological alterations corresponding to a severe acute inflammation were found in 12, 35 and 45 cases respectively. Single MG positive immunolabelling was observed in 4 cases, mainly in trachea and lungs, strong MS positive labelling, mainly in trachea, air sacs and lungs, in 16 cases whose 6 also exhibited a weak MG staining. The PCR amplification was positive in 14 out of the 16 IHC positive cases for MS (211 bp band) and in all IHC positive cases for MG (302 bp band), leading to high agreement scores (97.8% and 100% respectively) whereas MS and MG positive cultures were found in 12 and 3 cases respectively. The agreement scores between IHC and culture and between PCR and culture were 95.7% for the MS detection and 96.3% for the MG detection. Consequently, it was concluded that PCR and IHC methods offer a better sensitivity than the culture methods and may be used in the diagnosis of avian mycoplasmosis.


Demand Side Energy Management has now been established in the smart grid framework in order to meet the fluctuating demand-supply gap that exists mainly during peak load periods. Along with the potential of energy efficiency and conservation measures, due to the increasing use of domestic appliances in a developing country like India, Demand Response (DR) has gained a lot of importance in the residential sector. Most of the DR algorithms that have been developed mostly focus on energy consumption scheduling without considering electricity market prices. In this paper we have proposed a DR algorithm for residential consumers in India, which can be used to optimally schedule appliances, making use of actual day-ahead electricity market price data and also considering user preferences in the operation of appliances. The algorithm has been simulated for five different consumers using a flat pricing scheme and two time-differentiated pricing schemes. For each customer, an estimated saving of 6% can be obtained by using hourly pricing. Analysis of the results underlines the importance of formulating effective dynamic pricing policies for successful implementation of DR algorithms for the residential users thereby tapping into the vast DR potential that exists in India.


Communication system (300,1000) is a hybrid automatic repeat request (H-ARQ), Adaptive Modulation and Coding (AMC), corresponds in a distributed fashion active set handoff, and scheduling functions. Therefore, the mobile station (MS) (1014), the control information corresponding to the enhanced reverse link transmission is notified to the active set base transceiver stations (BTS) (301,303,304), a wireless network in the prior art control function controller (RNC) is corresponded to (314, 316, 318), to be executed by the BTS. This communication system enables H-ARQ flush functions based on time and SIR in BTS during soft handoff (SHO), enhanced reverse link, i.e., the scheduling process for uplink channel (414), H -ARQ, is provided a control channel structure corresponding to the AMC function, increase throughput to the maximum, MS in SHO region, corresponding to the best TFRI out of multiple assignments it receives from multiple active set BTS it is possible to select a scheduling assignment.


This paper presents a review of research into the performance of blast walls in providing protection against the damaging effects of a blast wave generated by the detonation of a quantity of high explosive. Explosive sources might be military weapons such as aerially-delivered bombs or, more likely in the context of the current world situation, improvised explosive devices such as might be deployed by terrorist organisations. The paper reviews studies concerned with how blast walls achieve structural protection with particular reference to the importance of the blast wall's location relative to the threat and the asset that is to be protected. The question of what damage a blast wall might sustain, while still retaining its protective capabilities, is also discussed. The paper presents examples of both 'permanent' and 'temporary' blast wall designs and constructions used by both military and civilian organisations.


The paper by Rothleitner et al (2014 Metrologia 51 L9) reports on the measurement of the speed-of-light perturbation in absolute gravimeters. The conclusion that the perturbation reaches only of the commonly accepted value violates the fundamental limitation on the maximum speed of information transfer. The conclusion was deluded by unaccounted parasitic perturbations, some of which are obvious from the report.


Background and Purpose: There are several ways to enhance marriage. Prevention and Relationship Enhancement Program (PREP) are among the methods of educating relationships. Relationship education programs have made a significant contribution to the growth and development of millions of couples. This study aimed to investigate the effectiveness of the Prevention and Relationship Enhancement Program (PREP) on quality of life and marital commitment in married women.
Materials and Methods:  This quasi-experimental research was conducted in a pretest-posttest control group design with 15 participants in the experimental group and 15 participants in the control group. Marital Commitment Questionnaire (DCI), and World Health Organization Quality of Life Questionnaire (WHOQOL) were completed as research instruments by the participants. The full version of PREP.8 was presented to the group of 15 participants over a weekend for a total of 12 hours, with each segment lasting for two hours. The Multivariate Analysis of Covariance (MANCOVA) as well as the Univariate Analysis of Covariance (ANCOVA) tests were used. Hedge´s g effect size (ES) was also calculated to determine the magnitude of pairwise comparisons.
Results: The findings indicated that there was a significant difference between the experimental and control groups in terms of quality of life (Social Relations: Exp:12.27±1.28, Cont:11.13±1.64, P≤0.03; Environment, Exp:30.73±3.06, Cont:28.67±3.27, P≤0.02) and marital commitment (Structural Commitment: Exp: 76.40±5.08, Cont: 70.53±3.42; P≤0.02).
Conclusion: We concluded that utilizing PREP can successfully help Iranian couples in their relationships providing them with more knowledge and skills.


A field experiment was conducted during the winter seasons 2020-2021 and 2021-2022 in Haditha district, Barwana district, which is located in the northwestern part of the center of Anbar province and is characterized by its sandy, clay soil. In order to study the effect of bacterial inoculation and spraying with arginine and glutamic acids on the physiological traits of fenugreek (Trigonella foenum-graecum L). The experiment included (18) treatments resulting from the interaction of the bacterial bio-inoculation (Sinorhizobium meliloti) (inoculated and without inoculated ) with combinations of amino acids arginine and glutamic. The experiment was designed according to RCBD with a within the split plots. The results of the study showed a superiority of the inoculation treatment with (Sinorhizobium meliloti) in the traits of root growth. Also in the traits of vegetative growth. The combination of arginine 50 mg.L-1 + glutamic 50 mg.L-1 was significantly excelled in root growth traits. As well as in the traits of vegetative growth.


Abstract: LaFeO 3 system with doped Ti, Co, Cu was manufactured by solid state reactio n method, it was sintered at 1250 0 C and 1290 0 C in 10 hours with a heating rate of 3 0 C /min. Using X-ray diffraction and Scanning Electron Microscope (SEM) to examine the structure, it reveals that samples are single-phase and orthogonal -perovskite structure describing by the Pnma space group , the unit cell volume of the samples increases when Ti, Co, Cu are doped to replace ion Fe +3 . The size of particle increase while raising the temperature of sintering. Doping Ti, Co, Cu ions has strongly changed the magnetic properties of the sample system. Magnetic hysteresis loops M(H) and magnetocaloric M(T) of the samples are measured in different magnetic fields and show interesting results. All the samples shown strong f erromagnetism , among which La(Fe 0.4 Cu 0.1 Ti 0.5 )O 3 shown the strongest and its Curie temperature is about 450 0 C. Keywords: LaFeO 3 doped Ti, Co, Cu; m agnetic hysteresis loop M(H); magnetocaloric loop M(T); strong ferromagnetism


The article focuses on the analysis of translations of Polish poetry made by Isabella Grinevskaya who was active in the late nineteenth and early twentieth centuries. Her translations have been considered in the context of the literary dominants of the Silver Age period as well as principles, views and discourses of translation valid at that time. It also concentrates on Grinevskaya's religious and philosophical interests, which influenced her choices in translation. Attempts were also undertaken to demonstrate the art of Grinevskaya's translation, regardless of the historical period in which she created her works, as one of the links within Translation Studies.


................................................................................................................................ II List of Tables ....................................................................................................................... III List of Figures ...................................................................................................................... IV List of Abbreviations ............................................................................................................ V Acknowledgements .............................................................................................................. V


Adaptability and comprehensive evaluation of 12 Russian Cultivars and 1 Mongolian Cultivar of Sea buckthorn(Hippophae rhamnoides) were studied at 3 sites,Shuiling of Heilongjiang,Dengkou of Inner Mongolia and Yongshou of Shaanxi.The results showed:(1) The main affection factor was environmental factor for the adaptability of Large Berry Cultivars of Sea Buckthorn.In the development of Large Berry Cultivars of Sea Buckthorn,geographical location must be considered firstly;when the planting place determined,then the breed needed to be selected according to their adaptability.(2) The adaptability of Large Berry Cultivars of Sea Buckthorn originated from high latitude had the decreasing trend with the decreasing of latitude in China.Trial plots of Shuiling,Dengkou and Yongshou belonged to the best adaptable introduction region,the adaptable introduction region and the un-adaptable introduction region.(3)In Shuiling trial plot,the Large Berry Cultivars of Sea Buckthorn with the fruit production above 4 500 kg·hm-2 were Chuyi,Hunjin,Yousheng,Chengse,Aertaixinwen,Wulangemu;In Dengkou trial plot,the Large Berry Cultivars of Sea Buckthorn with the fruit production above 6 000 kg·hm-2 were Chuyi,Jinse and Yousheng,these introduced breeds were worthy of vigorously developing.(4)The adaptability region of Large Berry Cultivars of Sea Buckthorn in China could be divided into 3 regions: the best adaptable introduction region,such as Shuiling County,the adaptable introduction region such as Dengkou County and the cultivation-taming region such as Yongshou County.


This paper introduces an automatic flood mapping application that is hosted on the Grid Processing on Demand (GPOD) Fast Access to Imagery (Faire) environment of the European Space Agency. The main objective of the online application is to deliver operationally flooded areas using both recent and historical acquisitions of SAR data. Having as a short-term target the flooding-related exploitation of data generated by the upcoming ESA SENTINEL-1 SAR mission, the flood mapping application consists of two building blocks: i) a set of query tools for selecting the "crisis image" and the optimal corresponding "reference image" from the G-POD archive and ii) an algorithm for extracting flooded areas via change detection using the previously selected "crisis image" and "reference image". Stakeholders in flood management and service providers are able to log onto the flood mapping application to get support for the retrieval, from the rolling archive, of the most appropriate reference image. Potential users will also be able to apply the implemented flood delineation algorithm. The latter combines histogram thresholding, region growing and change detection as an approach enabling the automatic, objective and reliable flood extent extraction from SAR images. Both algorithms are computationally efficient and operate with minimum data requirements. The case study of the high magnitude flooding event that occurred in July 2007 on the Severn River, UK, and that was observed with a moderateresolution SAR sensor as well as airborne photography highlights the performance of the proposed online application. The flood mapping application on G-POD can be used sporadically, i.e. whenever a major flood event occurs and there is a demand for SAR-based flood extent maps. In the long term, a potential extension of the application could consist in systematically extracting flooded areas from all SAR images acquired on a daily, weekly or monthly basis.


Significance Targeting more than one molecular cause implied in the pathogenesis of Alzheimer's disease (AD) with a sole drug is considered a promising challenge, because it may address the numerous failures that recently occurred during clinical trials that were conducted in this area. Donecopride has been designed by us as a multitarget-directed ligand, targeting both serotonin subtype 4 receptor and acetylcholinesterase with excellent in vitro activities. The latter seems able to not only restore the cholinergic neurotransmission altered in AD but also, promote the secretion of a neurotrophic protein that is detrimental to the neurotoxic amyloid-β peptide. With its excellent drugability, donecopride further displayed significant procognitive effects in mice and generated a promising lead for a previously unidentified approach in AD treatment. RS67333 is a partial serotonin subtype 4 receptor (5-HT4R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the neurotrophic protein sAPPα. This effect has generated great interest in RS67333 as a potential treatment for Alzheimer's disease (AD). We show herein that RS67333 is also a submicromolar acetylcholinesterase (AChE) inhibitor and therefore, could contribute, through this effect, to the restoration of the cholinergic neurotransmission that becomes altered in AD. We planned to pharmacomodulate RS67333 to enhance its AChE inhibitory activity to take advantage of this pleiotropic pharmacological profile in the design of a novel multitarget-directed ligand that is able to exert not only a symptomatic but also, a disease-modifying effect against AD. These efforts allowed us to select donecopride as a valuable dual (h)5-HT4R partial agonist (Ki = 10.4 nM; 48.3% of control agonist response)/(h)AChEI (IC50 = 16 nM) that further promotes sAPPα release (EC50 = 11.3 nM). Donecopride, as a druggable lead, was assessed for its in vivo procognitive effects (0.1, 0.3, 1, and 3 mg/kg) with an improvement of memory performances observed at 0.3 and 1 mg/kg on the object recognition test. On the basis of these in vitro and in vivo activities, donecopride seems to be a promising drug candidate for AD treatment.


IN his treatise known under the title of Hippike or The Art of Horsemanship, the historian Xenophon, writing towards the close of a busy and adventurous life, furnishes the Greek cavalryman with much expert advice drawn from his long experience as a professional soldier. No small part of the essay is concerned with the question of the choice of a proper mount, after which the matter of defensive armor for the knight is examined.


This document defines a Cryptographic Message Syntax (CMS) profile for
a general purpose Resource Tagged Attestation (RTA), for use with the
Resource Public Key Infrastructure (RPKI). The objective is to allow
an attestation, in the form of an arbitrary digital object, to be
signed "with resources", and for validation to provide an outcome of
"valid with resources". The profile is intended to provide for the
signing of an attestation with an arbitrary set of resources.


(57) ABSTRACT A P-bar excitation system employs a generator having means for adjusting the voltage and current available from the P-bars. In some installations, the direct output of the P-bars can be connected directly to the rectifier and control circuit for development of dc excitation power. This permits elimination of the conventional excitation transformer and overall simplification of the excitation system. The voltage and current are adjusted using paired P-bars per phase, wherein each pair of P-bars is connected in series, and angularly displaced from each other about the inner circumference of the armature to attain a vector sum of voltages yielding and desired voltage per phase. In another embodiment, the generator magnetic flux, or equivalently, the number of armature turns is adjusted to yield the desired P-bar voltage and current.