Homozygosity for rs334 (GAG-GTG, glu6val) or sickle cell anemia is common in Saudi Arabia. In the Eastern Province the sickle hemoglobin (HbS) gene is usually on the autochthonous Arab Indian (AI) β-globin gene (HBB) haplotype [1]. The higher fetal hemoglobin (HbF) level in the AI haplotype is often associated with milder disease compared with other HbS-associated haplotypes, especially in children [2, 3].

The Xmn1 G-A (C-T) polymorphism (rs7482144) is present in both the AI haplotype and the Senegal haplotype. Rs10128556, which is in linkage disequilibrium (LD) with rs7482144, could be the functional SNP of the Senegal haplotype [4]. The minor alleles of these SNPs also characterize the AI haplotype where adults had ~20% HbF compared with ~10% HbF in the Senegal haplotype. This suggests that elements linked to rs10128556 and rs7482144 in the AI but not the Senegal haplotype might affect HbF gene expression.

We compared the genome-wide distribution of SNPs in Saudi patients with the AI haplotype and Benin haplotype. Variants distinguishing these populations were limited to chromosome 11p15.5. Annotation of these SNPs narrowed the selection to 3 that we analyzed jointly using haplotype analysis. Homozygosity for a T/A/T haplotype of rs16912979 (in HS-4 of the LCR), rs7482144 and rs10128556 was exclusive to the AI haplotype. The AI haplotype might include a functionally important sub-haplotype that accounts for high HbF.


Simple Summary The causative agents of Lyme borreliosis, spirochetes from the Borrelia burgdorferi sensu lato complex, can be transmitted via various life stages of the tick, making this disease a serious concern pertaining to One Health approaches. The detection of specific antibodies against Bbsl is generally achieved by using a two-tiered test approach based on an ELISA combined with a line immunoassay (LIA). In this study, canine and equine serum samples with known antibody status were tested with two different LIAs. Results were compared in term of sensitivity, specificity, diagnostic outcome for dogs and horses, as well as of operability of the test. For canine serum samples, reliable results can be achieved with both LIAs. In contrast, the serodiagnosis of horses is still challenging, and improvements of both LIAs are recommended. Abstract Lyme borreliosis is a vector-borne disease in humans and animals caused by bacteria from the Borrelia burgdorferi sensu lato complex (Bbsl). The possible transmission of Bbsl from companion animals to humans via ticks makes this disease important in terms of One Health approaches. Thus, early and accurate diagnosis and treatment are of utmost importance. Today's standard for the detection of specific antibodies against Bbsl is a two-tiered test system based on an ELISA for screening combined with a line immunoassay (LIA) for confirmation. In this study, 200 canine and 200 equine serum samples with known antibody status were tested with two different LIAs (A and B). Results were compared regarding sensitivity, specificity, the diagnostic outcome for dogs and horses, as well as operability of the test. The results for canine serum samples corresponded to 94.0%, making both LIAs a good choice for LB diagnostic in dogs. For equine serum samples, the agreement of both tests was 65.5%, displaying the challenge equine samples still provide in LB diagnostic. Major concerns were the interpretation of the OspA antigen (AG) signal and the use of unspecific (i.e., p100/p83) or too sensitive signals on the LIA. The operability of both LIAs was equally user-friendly. Regarding the tests' evaluation, the scanning process provided by LIA A was a major advantage considering the comparability of the tests.


Introduction: This paper provides an overview of the current immunologic research findings of lymphatic filarial worms, which affect millions of people worldwide.

Objectives: This paper aims to discuss the immunologic features of lymphatic filarial worms. It also aims to highlight their potential anti-inflammatory actions and the use of anti-filarial drugs against COVID-19.

Methods: A literature review was performed to obtain insights on the immunologic features of lymphatic filarial worms.

Results: The CD4+ (Th2) response profile is the main defence against filarial worms. Modulation of human immune responses are primarily mediated by parasite-secreted peptides. Lymphatic filarial worms have anti-inflammatory potentials. Drug repurposing of diethylcarbamazepine, doxycycline, and ivermectin can be looked upon against COVID-19.

Conclusion: Lymphatic filarial worms have several immunologic effects on host immune systems, which promote chronic infection and curtail anti-inflammatory responses. Insights in this paper can serve as a guide for the understanding of immunologic aspects of lymphatic filarial worms.


Abstract Future research activity in toxic shock syndrome should provide further understanding of the ways different host-defense mechanisms are involved in toxic shock syndrome; such efforts must ...


Abstract In the past few decades we have witnessed an explosion of suburban office development, but we are only beginning to understand the pattern of development that is emerging. In this article six longitudinal case studies are used to test the validity of four descriptive theories of office suburbanization. Urban villages, office corridors, and other popular theories prove to be too simple to capture the actual complexity in the case studies. A more complex pattern is evolving in which the majority of office space is located outside the regional CBD, with some scattered away from freeways, but most located in a large number of small and moderate-sized, low intensity clusters along freeway corridors. It will be important to evaluate the impacts of this emerging pattern on various planning issues and to better understand its underlying causes, if city planners wish to alter current trends. A new metropolis is upon us, and we need to understand what will be a critical element of the twenty-first century ...


The fate and transport of atrazine, including effects of photodegradation and a potential reaction with polysulfides, in the Upper Chesapeake Bay is investigated. A hydrodynamic model that includes all relevant physical and chemical processes is used to show that atrazine is transported vertically down the water column to the sediment water interface where it may react with naturally occurring polysulfides. Limited field data supports these results. Based on reaction rates reported in the literature, model results show that neither photolysis nor the reaction with polysulfides decrease the concentration of atrazine in the Upper Bay in any significant amount. Our modeling study shows that the minimum reaction rate required to decrease the concentration of atrazine in the bottom layer is 10 Ms. The wide range of reaction rates used to obtain these preliminary results suggests that a potential reaction between an herbicide or pesticide and polysulfides is not a significant removal mechanism for agrochemicals in the Upper Chesapeake Bay.


Civil Engineering Materials is one of the fundamental courses for the civil engineering majors. The paper analyzes the problems existing in the traditional experiment teaching of this course and discusses a new approach based on the Outstanding Engineers Training Program in the light of content, methodology, evaluation and long-term mechanism so as to improve students' learning ability, work attitude, hands-on skill and innovation ability, etc..


(NZB × NZW)F1 female (BW) mice spontaneously develop an autoimmune disease, characterized by the production of autoantibodies (autoAbs) and glomerulonephritis, which can be delayed by neutralizing IFN-γ Abs and accelerated by IFN-γ injections. To define the role of IFN-γ in the pathogenesis of glomerulonephritis, we established a population of BW mice deficient in IFN-γR (BWγR−/−) by repeated crossing; these mice were compared with BWγR+/+ and +/− littermates. Of the BWγR+/+ and +/− mice, 50% showed immune complex glomerulonephritis with heavy proteinuria at 8 mo of age, while only 10% of the BWγR−/− mice were affected at 14 mo. The serum concentration of anti-dsDNA and anti-histone Abs was dramatically reduced in BWγR−/− mice. The role of IFN-γ in promoting class switch to IgG2a and IgG3 could not fully account for the impaired production of anti-dsDNA in BWγR−/− animals since, IgM and IgG1 levels were also reduced. There was a high incidence of B cell lymphoma in the BWγR−/− mice, which might be related to the suppression of autoAb production. Thus, the absence of glomerulonephritis in BWγR−/− mice is likely due to a dramatic yet unexplained effect of the inactivation of IFN-γ signaling on autoAb production.


We consider the most general action for gravity which is quadratic in curvature. In this case first order and second order formalisms are not equivalent. This framework is a good candidate for a unitary and renormalizable theory of the gravitational field; in particular, there are no propagators falling down faster than 1/p2. The drawback is of course that the parameter space of the theory is too big, so that in many cases will be far away from a theory of gravity alone. In order to analyze this issue, the interaction between external sources was examined in some detail. We find that this interaction is conveyed mainly by propagation of the three-index connection field. At any rate the theory as it stands is in the conformal invariant phase; only when Weyl invariance is broken through the coupling to matter can an Einstein-Hilbert term (and its corresponding Planck mass scale) be generated by quantum corrections.


Ovarian cancer is usually diagnosed when the disease is tions, like screening tests for cancer, using either an information-seeking (monitoring) or information-avoiding (bluntat an advanced stage. The low survival rates associated with advanced ovarian cancer have contributed to the concern that ing) coping style [4, 5]. The minimizers in the Robinson article would be expected to show a preference for a blunting effective screening tests be developed to detect the disease at an earlier, and potentially more treatable, stage. However, style; they are apparently avoiding information about their cancer risk. It should be noted that this coping style appears screening for serious diseases such as ovarian cancer is not without drawbacks. In addition to limitations of the screento be quite effective at managing negative affect; the minimizers had the lowest levels of depression and anxiety. Moning methods themselves, ovarian cancer screening can affect, and be affected by, psychological distress in the individuals itors, on the other hand, actively seek out information in an attempt to manage their anxiety; they may amplify the threats undergoing this process. Psychological factors can affect a person's approach to cognitively and emotionally [5]. These individuals are most likely to seek out ovarian cancer screening and genetic testmedical care and preventive actions. Such factors have been studied with respect to cancer screening, although at this ing and may overutilize it. Monitors perceive themselves to be at higher risk for the disease [6] and are less likely to time most of the psychosocial research has focused on cancer screening procedures that are recommended for large sectors successfully manage their distress. However, their distress will be lower if they are able to receive the information they of the general population (e.g., mammography, pap tests, fecal occult blood testing, flexible sigmoidoscopy). seek; they are most stressed by situations in which adequate information is not provided [7]. Why should clinicians be concerned with the psychological issues that affect the ovarian cancer screening process? The article by Robinson et al. points out a second implication of psychological factors in ovarian cancer screening. The article by Robinson and colleagues [1] featured in this issue of Gynecologic Oncology highlights one reason. PsyThe psychological characteristics of the patients before screening appeared to affect the way that patients filtered chological characteristics of individuals in the population at risk have an impact on who presents for ovarian cancer and interpreted information about their risk. A high level of depression before the screening was related to higher perscreening. Robinson et al. found that women attending a clinic for ovarian cancer screening were more depressed and ceived risk after counseling about their risk, regardless of the level of risk estimated and relayed to the patient by the anxious than the general population. Additionally, only 17% of the screening patients were in the ''minimizer'' group, clinical team. The investigators found that the women who accurately perceived themselves as being at high risk were i.e., those patients who, after being educated by the clinical team about their elevated level of risk for ovarian cancer, the most depressed, followed by the group who perceived their risk to be higher than the risk estimates they received still perceived their risk as lower. The low percentage of patients in this group is not surprising, as women who perin their counseling session (the ''overestimators''). Returning to the monitoring and blunting constructs, we can ceive their risk as low despite evidence to the contrary are much less likely to seek out ovarian cancer screening. Low infer that the ''overestimator'' group identified by Robinson and colleagues shows a preference for a monitoring coping perceived risk has been found to be negatively associated with obtaining screening for cervical cancer and breast canstyle; in characteristic monitoring fashion they have amplified their risk of ovarian cancer. cer in some studies as well [2, 3]. Suzanne Miller has identified two styles of coping with If individuals' psychological distress affects how they interpret information about risk based on family history data, stressful situations that can be useful in understanding these data. Miller theorizes that people cope with stressful situawe also may expect that their psychological distress will


To the Editor.— InThe Journal, Morris and Goldschlager1describe a beneficial response to intravenous (IV) calcium chloride in a patient who had verapamil-induced hypotension, low cardiac output, and bradycardia. While they stated that reversal of these adverse effects outweighed any possible vasodilating effect of calcium chloride, they cautioned against its use by stating that "the potential vasodilating effect of IV calcium chloride infusion (but not the gluconate, gluceptate, or lactate preparations) must be considered when using IV calcium to reverse adverse effects of verapamil," implying that these other preparations may be better. When using calcium gluconate to reverse verapamil overdosage, some authors have reported a poor response.2,3Furthermore, when IV calcium gluconate is compared with calcium chloride, the body's retention of calcium is less,4extracellular ionized calcium increases less predictably,5and the positive inotropic effect of equimolar amounts is not as great.6 If a


Linear dynamically varying (LDV) control is a technique for getting a natural (nonlinear, possibly chaotic) trajectory and a perturbed trajectory asymptotically synchronized given an initial condition offset. Probably the best illustrative example, which motivates this paper, is tracking the natural (possibly quasi-periodic) motion of a Trojan asteroid near the L4 point of Jupiter with a spacecraft that follows a trajectory perturbed by the non conservative propulsion forces. The tracking error is linearized around the natural dynamics of the Trojan body, leading to an LDV model of the tracking error. This in turn leads to a dynamically varying controller, itself given as the solution to a Partial Differential Riccati Equation, solved via the method of characteristics. It is shown that this technique allows for accurate tracking of the complicated dynamics around the L4 point.


Computers brought automation to industries such as chemicals, steel, and power generation during the 1960s. Real-time control of major industrial processes was achieved using Cold War hardware.


By splitting the well drive-in into two parts, before and after the field oxidation, it is possible to compensate the segregation effects due to field oxidation without having to increase the well concentration in the active areas. Due to the smaller dopant gradient between isolation and active areas, nearly neutral transistor-width dependence is achieved, resulting in width-independent transistor degradation behavior. Only in the case of threshold-voltage-adjustment directly by the p-well concentration is a weak reverse narrow-width effect observed. The reliability results show that the width effect on lifetime is turned eliminated. The lifetime reduction with decreasing transistor width, normally so critical for field-implanted devices, is not a problem.<<ETX>>


The present study compared the occurrence of estrus behavior and ovulation in response to the insertion of CIDR devices plus a classical treatment with equine chorionic gonadotrophin (eCG; single dose at CIDR removal) or alternative treatments with gonadotrophin-releasing hormone (GnRH, either in a single dose at 56 hours after CIDR removal, or in one dose at CIDR insertion and another dose at 56 hours after CIDR removal). The appearance of estrus behavior during reproductive season ranged between 84% and 95% and all females showing estrus signs had subsequent ovulations. The response, during seasonal anoestrus, was similar in the group treated with eCG, but less than half of the females in the groups treated with GnRH showed estrus signs in response to the treatment, although more than 80% of them showed resumption of ovulatory activity after the treatment. In conclusion, protocols based on GnRH administration offer similar yields to eCG-based protocols during the reproductive season but occurrence of estrus in response to GnRH-based treatments is highly compromised during seasonal anoestrus.


Audio recording/reproduction techniques have been investigated to further the realization of highly realistic communication. However, to achieve ultra-realistic communication, a real-time acoustic rendering technique must be developed along with current recording and reproduction techniques. Acoustic simulation is a promising way to simulate, predict, and render acoustic phenomena. However, it is difficult to apply conventional computational methods to real-time acoustic rendering for large-scale sound fields. Therefore, we propose a new acoustic simulation technique to realize real-time acoustic rendering of a large-scale sound field. The proposed method, based on a lattice gas cellular automaton (LGA), is called sound-field LGA. This paper introduces details of sound-field LGA, including a physical interpretation of the simulation and an application of 1-bit coding for source signal representation. Furthermore, preliminary results are demonstrated and discussed.


Following the emergence of COVID-19 in December 2019, which dramatically transformed our lives, concerns arose regarding the risk of a new infectious agent that may impact all of our lives, particularly after the emergence of monkeypox cases in 2022 in geographical locations where it is not supposed to be seen. We have noticed that pediatricians and all healthcare professionals working on children's health, in particular, need to refresh their knowledge of this zoonotic disease in greater depth due to information received that it may severely impact children and the fetus throughout the intrauterine period. Essentially a zoonotic infection, monkeypox is a disease caused by the pox virus and transferred from animals to humans. It can also spread from person to person through close contact. Typically, it has symptoms similar to a milder form of smallpox, and spontaneous recovery can be seen in two to four weeks (1). Vesicular rash, fever, weakness, severe fatigue, muscle pain, and generalized lymphadenopathy are the hallmark symptoms. As previously stated, children, fetuses, and people with immunodeficiency or immunosuppression may experience a more severe course of the disease (2). Monkeypox is endemic in 10 countries in Central Africa (especially the Democratic Republic of the Congo) and West Africa (especially Cameroon and Nigeria) (3). Its mortality rate is 3% in Central Africa and 1% in West Africa, based on the reports after the 1980s. It was first identified in monkeys in 1958 at the Statens Serum Institute in Copenhagen, Denmark, which is why it is also referred to as monkeypox. The first human case was reported in 1970 in the Democratic Republic of Congo. By 2022, cases were identified in all continents except Antarctica, and as of August 2022, a total of 28.219 cases were reported. According to the Ministry of Health, five cases have been reported in our country.


ABSTRACT This paper studies free vibrational behavior of porous nanocomposite shells reinforced with graphene platelets (GPLs). GPLs are uniformly and nonuniformly distributed thorough the thickness direction. Different porosity distributions called uniform, symmetric, and asymmetric are considered. The elastic properties of the nanocomposite are obtained by employing Halpin–Tsai micromechanics model. The GPL-reinforced shell is modeled via first order shear deformation theory and Galerkin's method is implemented to obtain vibration frequencies. New results show the importance of porosity coefficient, porosity distribution, GPL distribution, GPL weight fraction, and geometrical and foundation parameters on vibration behavior of porous nanocomposite shells.


Thinking of joining a university or college board? Phillip Cenere reports on a recent symposium in Sydney where the key lessons on risk management in the tertiary education sector were discussed.


Tender nodular lesions on palms can mimic other dermatoses and might be a clue to serious internal diseases. Neutrophilic dermatosis of dorsal hands is a rare localized variant of Sweet's syndrome.[1,2] Clinically, it presents as violaceous oedematous plaques, bullous, haemorrhagic, and ulcerated lesions on dorsal hands. However, only palmar involvement in NDDH is still less reported.[2,3] Review article on 123 cases of NDDH by Micallef D et al. reported only 5 cases having palmar involvement.[4]


The so-called 'refugee crisis' provoked a wave of solidarity movements across Europe. These movements contrasted with attitudes of rejection against refugees from almost all EU member states and a lack of coordinated and satisfactory response from the EU as an institution. The growth of the solidarity movement entails backlash of nationalized identities, while the resistance of the member states to accept refugees represents the failure of the cosmopolitan view attached to the EU. In the article, we argue that the European solidarity movement shapes a new kind of cosmopolitanism: cosmopolitanism from below, which fosters an inclusionary universalism, which is both critical and conflictual. The urban scale thus becomes the place to locally articulate inclusive communities where solidarity bonds and coexistence prevail before national borders and cosmopolitan imaginaries about welcoming, human rights, and the universal political community are enhanced. We use the case of Barcelona to provide a concrete example of intersections between civil society and a municipal government. We relate this discussion to ongoing debates about 'sanctuary cities' and solidarity cities and discuss how urban solidarities can have a transformative role at the city level. Furthermore, we discuss how practices on the scale of the city are up-scaled and used to forge trans-local solidarities and city networks.


An apparatus and method for the pelletization of waxes, wax-like and other materials having a sharp melt point include a vessel for forming the wax into a hot molten material. A heat exchanger then cools the molten wax to a temperature just above its melt temperature. The cooled liquid wax is fed to an extruder which further reduces the temperature and mixes the liquid wax into a thoroughly mixed extrudable solid wax. The solid wax is then extruded through die orifices of a die plate into a cutting chamber, and a rotary cutter cooperating with the die face of the die plate cuts the extruded solid wax strands into pellets. The die plate, cutting chamber and rotary cutter can have the same structure as an underwater pelletizer, but operating without water or liquid as a dry face pelletizer. The thus formed wax pellets drop out of the cutting chamber by gravity through an opening in the bottom thereof.


Salmonella is one of the most important zoonotic pathogens and the
 consumption of pork meat is one of the major sources of human infection. The
 aim of this study was to investigate the presence of salmonella on pig
 carcasses. Samples were taken from slaughterhouse A in two instances
 (sampling I and II, a total of 300 samples) and in slaughterhouse B once
 (sampling III, a total of 120 samples), from pork carcasses after the
 stunning and after the processing. Of the total number of examined samples,
 the percentage of positive samples for salmonella from pork carcasses after
 stunning was 46.7% (90/42), and samples from the carcasses after processing
 3.3% (90/3). Operations taking place on the slaughter line could have an
 effect on the salmonella contamination of carcasses.


We address the control synthesis of hybrid systems with discrete inputs and outputs. The control objective is to ensure that the events of the closed-loop system belong to the language of the control requirements. The controller is sampling-based and it is representable by a finite-state machine. We formalize the control problem and provide a theoretically sound solution based on finite-state abstractions of the symbolic behavior of the plant. In addition, we identify classes of hybrid systems for which a suitable finite-state abstraction can be computed and we sketch the corresponding algorithms.


Speaker recognition is a technology that recognizes a person's identity through a person's voice. Speaker recognition is one of the important research topics in the field of biometrics. This article first introduces the background and research significance of speaker recognition; secondly, it briefly introduces speaker recognition technology; again introduces the method research used in speaker recognition; and finally analyzes the research difficulties and challenges of speaker recognition.


A guide to the new revision of the Stanford-Binet tests.-For more than twenty years the Stanford Revision of the Binet-Simon Scale has been the leading test for the careful mental measurement of the children of this country, notwithstanding certain weaknesses which are well known. The publication of a new revision of the Stanford-Binet tests and of a new guide' to the administration of the tests is therefore an event of interest, not only to specialists in testing, but to school people in general. The guide for the tests is somewhat similar in general form to its epochmaking predecessor, The Measurement of Intelligence, published twenty-one years earlier. The new guide consists of five parts, the first of which contains a discussion of the new revision. The four other parts provide detailed instructions for administering and scoring the tests. The body of the book is followed by an extensive appendix, which contains tables showing intelligence quotients for all chronological and mental ages. Persons not actually engaged in administering the revised tests will be mainly interested in the first seventy-one pages, comprising Part I of the book. This part contains four chapters. In chapter i the essential features of the revision are outlined. In chapter ii the development and the standardization of the scales, involving ten years of experimentation, are reviewed. Chapter iii presents a statistical analysis of the scores that have been obtained with the revised tests. Chapter iv gives general instructions for administering the tests. No commentary on this new book would be complete without a summary of the more important features of the new scales with which it is concerned. Important innovations have been introduced which are designed to eliminate most of the weaknesses in the earlier scale. The older revision consisted of only one form. The newer one contains two forms, L and M, which are very different in content but are equivalent in difficulty and range. The older scale was satisfactory in the range from five to ten years but was defective at both extremes. The newer scales cover a much wider range, are more accurately standardized, provide a more extensive sampling of abilities, and are less verbal than the old scale, especially in the lower years. The new revision starts with age two, instead of age three, and there are tests at half-year intervals below age five. At the other end of the scales the gaps that existed in the preceding revision at years eleven and thirteen have been filled, and two supplementary superior adult levels have been added. The increased sampling provided by the new scales is indicated by the fact that, while Binet's original scale consisted of 54 tests and the first Stanford revision of 9o, each form of the new revision contains 129 tests. Notwithstanding the changes that have been made, the major concepts of Binet's original scale and the first Stanford revision have been conserved. The


Following the formulation of the constitutive model in the preceding Part I in this issue, the present Part II addresses the problems of computational algorithm and convergence of iterations. Typical numerical responses are demonstrated and the parameters of the model are calibrated by test data from the literature.


Based on the principle of corresponding states, a method developed for prediction the viscosity of liquid petroleum products that differ significantly in physicochemical properties and fractional composition. New approaches to the determination of the reduced temperature and viscosity are proposed. The initial data for the computation are the molar mass, the average volume boiling point and the relative density at 20 °C. Testing of the new technique in the temperature range (0.4–0.7)Tpc at pressures up to 10 MPa showed that the deviation of the predicted viscosity values from the experimental data is comparable with the experimental error.


We present phase-resolved spectroscopy of the short-period cataclysmic variable WZ Sge obtained with the Hubble Space Telescope. We were able to resolve the orbital motion of a number of absorption lines that likely probe the environment near the accreting white dwarf. The radial velocities derived from simultaneous fits to 13 absorption lines indicate an orbital velocity semi-amplitude of KUV = km s-1. However, we find that the phase zero is offset from the white dwarf ephemeris by +0.1. Our offset and velocity amplitude are very similar to constraints derived from optical emission lines from the quiescent accretion disk, despite the fact that we are probing material much closer to the primary. If we associate the UV amplitude with K1, our dynamical constraints together with the published K2 estimates and the known binary inclination of i = 77 ± 2 imply 0.88 M☉ < M1 < 1.53 M☉, 0.078 M☉ < M2 < 0.13 M☉, and 0.075 < q = M2/M1 < 0.101. If we interpret the mean velocity of the UV lines [- km s-1] as being due to the gravitational redshift caused in the high-g environment near the white dwarf, we find vgrav = km s-1, which provides an independent estimate on the mass of the primary of M1 = M☉ when coupled with a mass-radius relation. Our primary mass estimates are in excellent agreement and are also self-consistent with spectrophotometric fits to the UV fluxes despite the observed phase offset. It is at this point unclear what causes the observed phase offset in the UV spectra and by how much it distorts the radial velocity signature from the underlying white dwarf.


Based on the techniques of GIS/RS and the methods of the landscape ecology,the characteristics of the landscape changes and driving forces in midstream of Heihe mainstream basin from 1985 to 2005 were analyzed in the paper,especially the changes of landscape after water redistribution scheme in Heihe River basin was executed.The results showed as follows:(a) The landscape had changed greatly in Heihe River basin from 1985 to 2000,the farmland,woodland,resident and industry land increased,while grassland,water area and unused land decreased;the farmland,resident and industry land continued to increase from 2000 to 2005,and the changes of other patch type was adverse.(b) After 2000,at the class level,farmland and resident and industry land have become more fragmented,along with the area increasing,and patch shape has tended to be more regular,and the spatial connectedness of these two types increased gradually.The fragmentation,spatial connectedness and landscape dominance of woodland,grassland,water area and unused land had similar change trends.The fragmentation increased,but the spatial connectedness and landscape dominance of these four types decreased respectively.(c) At the landscape level,the diversity,heterogeneity and fragmentation of landscape increased after 2000,while the spatial connectedness and landscape dominance decreased.(d) The main forces of landscape change included population growing and the economic development.However,the reduce of available water resources in Heihe River has become the main force since 2000 which caused the significant changes of the landscape change.


Issues of the sustainable inclusive (comprehensive) growth of the global economy are discussed wordwide. Relevant programme desictions are being made at the national and international levels. In a number of countries natiotal strategies for the inclusive growth are being developed using the agreed upon indicators. Despite the policy efforts of developed and developing countries, the global economic recovery remains fragile. This paper focuses on the development issues of the countries of the Asia-Pacific region in the post-crisis period and considers such aspects as inequality and poverty. The gross national income of Mongolia in 2013 is presented, and shifts in the gross domestic product per capita in 33 countries during 2010-2014 are described. The comparative analisys of the gross domestic product of Mongolia and Mongolias neighbourhood countries Russia and China was performed. It was established that due to the ill-advised fiscal and budget policy Mongolia is at a high risk of debt distress. The current research concluded that in the conditions of the global economic crisis priority should be given to the accumulation of the budgetary resources.


Initially 4 branches of industrial engineering were chosen and experts were interviewed in each of them, to establish the main situations that a professional must face and solve through the application of the different tools offered by the career. The scope, critical success factors for implementation of these tools in the industry, key indicators to be improved, and the necessary information requirements necessary to achieve the expected results of this type of projects, were also identified.
Once obtained above refered information, a common reference framework to evaluate the operational impact of the tools, taking into account the influence that, the improvement of key indicators established by each industrial engineering tool, can have in different areas of the company, and in it's income , Invoicing, capacity to meet product/service demand costs inventories, etc.
Afterwards, study cases of the different industrial engineering tools and their impact on the creation of financial value were analyzed. To achieve this, it was necessary to perform an incremental analysis, comparing the future financial flows of the proposed situation to the financial flows of the current situation, in order to measure the economic value creation of each project.
Finally, a sensitivity analysis was performed to identify which indicators used to evaluate the project and the improvements in the operation of the company, are also critical to create financial value.


[Benthic Foraminifera of the Holocene from Golfo Nuevo, Argentine: paleoclimatical inferences]. Benthic Foraminifera from a recent Holocene core from Golfo Nuevo were analyzed. The fauna recovered was benthonic, and the predominant species were Buccella peruviana f. campsi (Boltovskoy), Buliminella elegantissima (d'Orbigny) and Bulimina patagonica d'Orbigny. Qualitative and quantitative analyses confirmed marginal marine conditions with lower oxygenation levels than under present-day conditions. This may have been a consequence of deterioration in climate which, due to its magnitude and persistence could have inverted the direction of the gulf's current thermohaline circulation, in which case it would represent a probable consequence of the so-called Little Ice Age.


6. Magnetic Clouds.- 6.1 Introduction.- 6.2 Definition and Properties of Magnetic Clouds.- 6.3 Origin and Composition of Magnetic Clouds.- 6.4 Model of the Local Structure of Magnetic Clouds.- 6.5 Large-Scale Structure of Magnetic Clouds.- 6.6 Motion and Stability of Magnetic Clouds.- 6.7 Nonthermal Particles and Magnetic Clouds.- 6.8 Effects of Magnetic Clouds on Geomagnetic Activity.- 6.9 Effects of Magnetic Clouds on Galactic Cosmic Rays.- 6.10 Magnetic Clouds and Compound Streams.- 6.11 Questions Concerning Magnetic Clouds.- References.- 7. Interplanetary Slow Shocks.- 7.1 Introduction.- 7.2 Generation of Interplanetary Slow Shocks.- 7.2.1 Steepening of Slow-Mode Waves.- 7.2.2 Magnetic Field Line Merging.- 7.2.3 Interaction of Interplanetary Discontinuities.- 7.2.4 Summary.- 7.3 Solar Wind Constraints on the Development and Evolution of Interplanetary Slow Shocks.- 7.3.1 Constraints on the Development.- 7.3.2 Constraints on the Evolution and Propagation.- 7.3.3 Summary.- 7.4 Constraints on the Unique Identification of Interplanetary Slow Shocks from Space Observations.- 7.4.1 The Classical Way.- 7.4.2 Additional Conditions.- 7.4.3 Implications of Checking Against Tangential Discontinuities.- 7.4.4 Examples.- 7.4.5 Summary.- 7.5 Summary.- References.- 8. Kinetic Physics of the Solar Wind Plasma.- 8.1 Introduction.- 8.1.1 General Remarks.- 8.1.2 The Importance of Kinetic Physics.- 8.1.3 Outline of the Article and Previous Reviews.- 8.2 Particle Velocity Distributions.- 8.2.1 Introduction.- 8.2.2 Ion Velocity Distributions.- 8.2.3 Electron Velocity Distributions.- 8.3 Coulomb Collisions and Nonclassical Transport.- 8.3.1 General Remarks.- 8.3.2 Observations on the Role of Coulomb Collisions.- 8.3.3 Kinetic Modeling of the Effects of Coulomb Collisions.- 8.3.4 Towards a Nonclassical Collisional Transport Theory.- 8.4 Wave-Particle Interactions and Anomalous Transport.- 8.4.1 General Remarks.- 8.4.2 Electrostatic Waves and Plasma Instability.- 8.4.3 Electromagnetic Waves and Plasma Instability.- 8.4.4 Electron Heat Flux Regulation.- 8.4.5 Regulation of the Ion Temperature Anisotropy and Heat Flux.- 8.4.6 Regulation of the Electromagnetic Ion-Beam Instability.- 8.4.7 Some Nonlinear Aspects of Wave-Particle Interactions.- 8.5 Nonequilibrium Thermodynamics.- 8.5.1 Introduction.- 8.5.2 Differences Between Ion Parameters.- 8.5.3 The Equation of State and Nonequilibrium Thermodynamics.- 8.5.4 Radial Gradients of Heat Fluxes.- 8.5.5 Radial Gradients of Ion and Electron Temperatures.- 8.6 Dissipation of MHD Turbulence and Particle Heating.- 8.6.1 Kinetic Damping of MHD Waves.- 8.6.2 Damping of Alfvenic Turbulence by a Nonlinear Cascade.- 8.6.3 Particle Heating by Wave Dissipation.- 8.7 Energy, Momentum, and Mass Input into the Solar Wind.- 8.7.1 Coronal Boundary Conditions.- 8.7.2 A Brief Account of Coronal Structures and Associated Interplanetary Phenomena.- 8.7.3 Interplanetary and Coronal Energy Fluxes and Solar Wind Constants of Motion.- 8.7.4 Physics of the Thermal Potential.- 8.8 Conclusions.- References.- 9. Waves and Instabilities.- 9.1 Introduction.- 9.2 Electrostatic Waves.- 9.2.1 Electron Plasma Oscillations.- 9.2.2 Ion Acoustic Waves.- 9.3 Electromagnetic Waves.- 9.3.1 MHD Waves and Ion Cyclotron Waves.- 9.3.2 Whistler-Mode Waves.- 9.4 Conclusion.- References.- 10. MHD Turbulence in the Solar Wind.- 10.1 Introduction.- 10.1.1 General and Historical Remarks.- 10.1.2 The Importance of MHD Turbulence for Space Plasma Physics.- 10.1.3 Outline and Scope of the Article and Its Relation to Previous Reviews.- 10.2 Structures and Fluctuations in the Inner Heliosphere.- 10.2.1 Large-Scale Solar Wind Structures.- 10.2.2 Mesoscale Structures and Fluctuations.- 10.3 MHD Theory and Turbulence Diagnostics.- 10.3.1 Basic Equations.- 10.3.2 Alfven Waves and Magnetosonic Waves.- 10.3.3 Analysis of Random MHD Fields.- 10.3.4 Integral Invariants of Incompressible MHD.- 10.3.5 Turbulence Spectra.- 10.3.6 Analysis Techniques in the Time Domain.- 10.4 Nature and Morphology of MHD Fluctuations.- 10.4.1 Power Spectra in Terms of Elsasser Variables.- 10.4.2 Stream-Structure Dependence of Alfvenic Fluctuations.- 10.4.3 Compressive Fluctuations.- 10.5 Origin and Evolution of Solar Wind MHD Turbulence.- 10.5.1 Sources of Interplanetary Fluctuations.- 10.5.2 Radial Evolution of Alfvenicity.- 10.5.3 Radial Evolution of Spectra.- 10.5.4 Self-similarity and Origin of Turbulence.- 10.5.5 Evidence for the Dissipation of Turbulence.- 10.6 Theoretical Concepts of Turbulence Generation and Evolution.- 10.6.1 Numerical Simulations as a Guide to Interpreting Observations.- 10.6.2 Models of Turbulence for Inhomogeneous Media.- 10.6.3 Nonlinearities and Cascading.- 10.6.4 Compressibility and Pseudosound.- 10.7 Summary and Conclusions.- 10.7.1 Left-Out Topics.- 10.7.2 Observational Summary.- 10.7.3 Conclusions and Recommendations.- References.- 11. Energetic Particles in the Inner Solar System.- 11.1 Introduction.- 11.2 Modulation of Galactic Cosmic Radiation.- 11.2.1 Model Concepts.- 11.2.2 Observations.- 11.3 Interplanetary Propagation of Solar Energetic Particles.- 11.3.1 Transport Models.- 11.3.2 Magnetic Field Properties and Pitch-Angle Scattering.- 11.3.3 Observations of the Mean Free Path.- 11.3.4 The ?-dependence of the Scattering Coefficient.- 11.3.5 Summary, Open Questions, and Suggestions for Further Studies.- 11.4 Coronal Propagation.- 11.4.1 Brief Overview of Early Observations.- 11.4.2 Models.- 11.4.3 Recent Observations.- 11.4.4 Discussion.- 11.5 Particle Acceleration in Solar Flares.- 11.5.1 Acceleration Mechanisms.- 11.5.2 Selected Observations.- 11.5.3 3He-Rich Solar Particle Events.- 11.6 Particle Acceleration in Corotating Interplanetary Regions.- 11.6.1 Features of Corotating Events and Their Relation to the Solar Wind.- 11.6.2 Corotating Events Throughout the Solar System and Solar Cycle Dependence.- 11.6.3 Models of Corotating Event Generation and Transport.- References.


This report briefly discusses: solvation of charge separated states in mixed solvents; molecular orbital symmetry in excitation and charge transfer; and transient raman experiments.


Background: Based on the anti‐adhesive/anti‐aggregatory and permeability‐reducing properties of activated protein C (APC) and prostacyclin (PGI2), we analysed and compared these substances regarding their efficacy in counteracting transcapillary leakage of albumin in the lung and the gut, and in improving arterial oxygenation under a condition of inflammation.


PURPOSE: A method for displaying a character according to the state of a hand held radio communication terminal is provided to offer interest to a user according to the user of a terminal by displaying the character of a figure corresponding to the state change of the terminal. CONSTITUTION: An MPU(Micro Processor Unit) checks whether a use frequency is normal(302). In case that the use frequency is abnormal, the MPU checks whether the use frequency is less than a predetermined regulation value(308). If the use frequency is less than the predetermined regulation value, the MPU checks whether termination exists(310). If the termination exists, the MPU selects image data of a character image of an optimum figure among character images stored in a memory and voice data corresponding to the image data(312). The MPU displays an character image according to the image data through a display unit and outputs a sound according to the voice data through a speaker(314).


In this thesis, we focus on User authentication and e-authentication frameworks. We have found a disconnect between industry authentication solution and e-authentication framework. The contribution is to evaluate biometric solutions against the criteria of e-authentication frameworks.


Shunbei oilfield is located in the Midwest of Tarim Basin. Since 2018 many wells in the block have encountered broken formation, directional wells wellbore collapsed seriously, resulting drilling sidewells, with a huge loss of drilling costs. The influencing factors of igneous formation stability include internal and external factors. The internal cause refers to the formation instability caused by the strength anisotropy and strong in-situ stress nonuniformity of igneous formation. The external cause refers to various factors that cause the change of the external environment of the formation caused by drilling engineering, including the physical and chemical interaction between the drilling fluid and the formation, well trajectory and mechanical disturbance of the drilling string, etc. Based on the analysis of the influencing factors of wellbore stability in igneous rock, the technical countermeasures of wellbore stability in igneous rock formation are put forward and field tests are carried out. In the Permian fractured formation of Shunbei oil field,the idea of "prevention first, combination of prevention and blocking" is adhered to the first principles. Low density and low viscosity drilling fluid with low displacement is adopted to prevent the occurrence of lost circulation. The wellbore of the igneous rock intrusion in santamu formation of Ordovician is easy to collapse. By adopting special sealing structure and strengthening plugging and anti-collapse, combined with slurry plugging and well washing and refining engineering measures, the safe drilling of the igneous rock can be ensured.


The present invention proposes a scheme for transmitting data at a first device in a communication system made up of at least two devices performing a dormant state and an active state alternately, the second device. For this, it broadcast a message containing the state transition information to the first device adjacent to the device the active status transitions from the dormant state. The second device receives a message that contains the state transition information, and notifies that transmission data to the first device. If the first device being notified that the data transfer is sending a message to permit the transfer of data, and the second device receives the message to permit the transfer of data to the first device.


Introduction In recent years, veterinarians and Ipet owners alike have been made aware of the role of dietary minerals in the etiology of a feline lower urinary tract syndrome known as feline urological syndrome (FUS), or lower urinary tract disease. Much has been written in both the popular and professional press on this subject, and the present paper is intended to review some of that literature with the restriction that the subject will be limited to nutrition and environmental issues surrounding the etiology and treatment of the condition. Excluded will be consideration of critical treatment of the condition which has been amply treated elsewhere (1). The condition is marked by dysuria, hematuria, cystitis and obstruction. It also includes the presence of sabulous and matrix plugs which may be distinguished from other urinary calculi by their softer texture (1-3). The obstructions or calculi are struvite or magnesium ammonium phosphate.


ABSTRACT Effects of black plastic mulch and row covers on the performance of sweet potato production were evaluated. This study was conducted at E.V. Smith Research center, Shorter, Alabama. Treatments were: (1) black plastic mulch (BPM), (2) BPM + white, tinted, slitted plastic (WTSP) row tunnel, (3) BPM + spunbonded polyester (SPE) floating row cover, (4) BPM + clear, slitted plastic (CSP) row tunnel, and (5) bare soil (control). BPM + WTSP and BPM + SPE treatments produced the highest total yields, resulting in 46% and 34% increase over the control. BPM +. WTSP also produced significantly more U.S. #1 grade sweet potato roots as compared with the control. BPM and row covers accelerated vine growth. Results show BPM + WTSP and BPM + SPE to be alternative ways of increasing sweet potato yields.


1)
2-Thiouracil (2-TU) applied during low temperature treatment, inhibited flower formation in excised stem discs of Wedgwood iris. The inhibition was overcome by gibberellic acid (GA) and orotic acid but not by uracil or thymidine.

2)
The first signs both of an inhibitive effect on flower initiation by 2-TU and of GA promotion occurred at the beginning of the reproductive stage. Increase or decrease of the rate of development of the flower primordium could be established only two weeks later, during differentiation of stamens or tepals.

3)
The peak in respiration rate occurring in the bud at the beginning of the reproductive stage was entirely repressed by 2-TU and not restored on a medium containing 2-TU and GA.

4)
It is concluded that a specific RNA takes part in the earlier stages of flower formation in Wedgwood iris.

5)
The role of gibberellih-like substances in flower formation of the Wedgwood iris is discussed in the light of possible interaction with nucleic acid metabolism.


The primary responsibility of the Health, Safety, and Environment (HSE) Division at the Los Alamos National Laboratory is to provide comprehensive occupational health and safety programs, waste processing, and environmental protection. These activities are designed to protect the workers, the public, and the environment. Evaluation of respiratory protective equipment included the XM-30 and M17A1 military masks, use of MAG-1 spectacles in respirators, and eight self-contained units. The latter units were used in an evaluation of test procedures used for Bureau of Mines approval of breathing apparatuses. Analyses of air samples from field studies of a modified in situ oil shale retorting facility were performed for total cyclohexane extractables and selected polynuclear aromatic hydrocarbons. Aerosols generation and characterization of effluents from oil shale processing were continued as part of an inhalation toxicology study. Additional data on plutonium excretion in urine are presented and point up problems in using the Langham equation to predict plutonium deposition in the body from long-term excretion data. Environmental surveillance at Los Alamos during 1983 showed the highest estimated radiation dose from Laboratory operations to be about 26% of the natural background radiation dose. Several studies on radionuclides and their transport in the Los Alamos environment aremore » described. The chemical quality of surface and ground water near the geothermal hot dry rock facility is described. Short- and long-term consequences to man from releases of radionuclides into the environment can be simulated by the BIOTRAN computer model, which is discussed brirfly.« less


The Forest Inventory and Analysis Program (FIA) of the USDA Forest Service conducts a national inventory of forests of the United States. A subset of FIA permanent inventory plots are sampled every year for numerous forest health indicators ranging fiom soils to understory vegetation. Down woody material (DWM) is an FIA indicator that refines estimation of forest structural diversity, forest area fuel loadings, and national carbon sources. DWM comprise fine woody debris, coarse woody debris, slash piles, duff, litter, and shrub/herbs. Components of DWM are sampled using planar intercept methodologies, fixed-radius sampling, and point sampling. DWM data analyses produce core tables, regional/national reports, wildlife habitat assessments, and fuel maps. The DWM inventory began in 2001 and is currently implemented in 38 states.


Firms are acknowledged to be important actors involved in the deployment of resources available to a tourism destination. In turn, successful tourism firms can contribute to building the competitive advantage of tourism destinations through affecting a destination's tourism product or service. The present study analyses business performance in urban tourism using networks and entrepreneurial perceptions over a city's asset base as a framework of competitive performance. Business performance is measured in terms of productive efficiency—that is, technical and scale efficiency. Results indicate that networks and entrepreneurial perceptions of a city's asset base constitute important determinants of the successful operation of tourism businesses.


The variation feature of gravity field and seismicity before and after Fanxian ML4.3 earthquake discussed.Since May in 2003,the gravity field showed a tendentious descent-ascent-accelerative ascent style,and the earthquake occurred in accelerative change stage.After the tendency anomalies of point-value at some measuring stations and of segment-value of measuring segment lasted a considerable time,the variation amplitudes were(30~60)×10-8m·s-2.After the earthquake the gravity anomaly in this region did not recovered.Variations of gravity field in this area may be caused by the earth crust deformation,quality transition in deep crust and fault creep deformation.Meanwhile the earthquake prediction according to the gravity anomalies is introduced.


Summary
Extraction of equine incisor and canine teeth is a vital part of equine dentistry. Although dental pathology involving the incisor and canine teeth is less common, the practitioner should be prepared to diagnose conditions and develop a treatment plan. Depending on the pathology revealed via oral examination and intraoral radiographs, the treatment plan may include either simple (nonsurgical) or surgical extraction of an incisor or canine tooth. Technique and instrumentation refinement over the last 20 years has led to more precise extraction procedures with reduced secondary trauma to healthy tissues. As a result, incisor and canine extraction procedures are more predictable in execution and quality, with minimal complications.


One in three women with pelvic organ prolapse (POP) undergoing surgery have a relapse. Currently, no optimal surgical treatment has been identified for correcting a uterine prolapse. This population‐based register study aims to compare the relapse rate in patients with uterine prolapse undergoing hysterectomy with suspension or uterine‐sparing surgical procedures.


Instead of using only one notion of selection I argue for a broader typology of different types of selection. Three such types are differentiated, namely simple one-step selection, iterated one-step selection, and multi-step selection. It is argued that this more general and more inclusive typology might face more effectively the possible challenges of a general account of selection.


The borders of visual art on the eve of the 20th-21st centuries are being extremely expanded both at the empirical and theoretical levels and so is the agenda of contemporary philosophy of art. Is the unprecedented polyphony of discourses a methodological drawback or is it a heuristic opportunity that can help to broaden our knowledge about the essence of art and the notion of a work of art? What is visual art and what is artwork speaking the 21st century language?
The study examines the current trends and innovations in the visual arts field and how they can be interpreted. Authors come to conclusion that the times of normative or negativist approaches are over. The plethora of transformations is a value-in-itself and can be seen as a legitimate methodological situation, namely, as a meta-relativist turn. Examples that are presented in the paper deal with different sides of "a work of art formula": span of discourse, artist, audience, art space, art market, new technologies, etc. Those cases demonstrate the ambivalence of current visual art practices that can be interpreted either as complete negation of the preceding standards or as new discourses that are equally legitimate with the older ones. Meta-relativist approach treats all existing discourses and practices as equally legitimate and thus provides the method to broaden our understanding of the essence of art and definition of an artwork. The study suggests that it is a contemporary tool for further intra- and inter-disciplinary dialogue.


A monolithically integrated high-speed true-time-delay line with embedded electrically switchable Bragg gratings was developed and characterized. Such a monolithically integrated device structure leads to a significantly reduced device size and allows a more precise RF phase control. A 40 ps reprogrammable optical true-time delay increment was acheived with a very fast switching speed of <50 µs.


Mechanical distortion of tortuous coronary arteries mimicking spasm or dissection during percutaneous transluminal coronary angioplasty due to balloon guidewire systems has previously been reported. This case reports a similar phenomenon in the peripheral vascular system induced by a diagnostic catheter. Recognition of this pseudo lesion may help to avoid complications and unnecessary intervention.


Genomewide expression profiling has shown promise for predicting outcomes in hepatocellular carcinoma (HCC) patients. However, development of genome-based predictors has been hampered by the requisite use of frozen tissue samples. Now, investigators have tested whether a novel gene-expression profiling technique in formalin-fixed, paraffin-based tissue samples can predict survival in HCC patients.

Gene-expression profiling of more than 6000 human genes was performed in a training …


The experiments were conducted at Yuershan Farm of Chengde City in Hebei province to study the differentiation and formation of young spike of siberian wildrye seeded two years ago.The morphological changes of shoot apex appeared with siberian wildrye plants growing.According to the characters of the differentiation,the course of differentiation of young spike of siberian wildrye can be divided into vegetative stage,elongation stage, single ridge stage, double ridge stage, spikelet protuberances stage, glume protuberances stage, floret initiation stage, stamen and gynoecium initiation stage.


This paper offers an appreciative critique of Kim Etherington's recent book, Narrative Approaches to Working with Adult Male Survivors of Male Child Sexual Abuse. I discuss the issues raised in the book with reference to one of my current clients. Etherington does not produce new substantive theory: the power of this work is in the narrative. Her important contribution lies in the reflexivity with which she encounters her material. The use of critical reflexivity challenges the subject/object dichotomy inherent in much positivistic research, and presents a much-needed approach to process that is congruent with the lived experience of counselling. I would suggest that research is more likely to succeed in informing practice if the material is open to personal interpretation by the reader/therapist. Further, I would claim that the activity of using research creatively is itself a heuristic process: useful learning is most likely to occur if the dialogic relationship with the client and therapist is mirrored in the relationship between the therapist and the research text.


AML is frequently diagnosed in elderly patients, with a median age of 69. Many older patients cannot tolerate intensive chemotherapy and/or stem cell transplantation, making curative treatment difficult and rates of early relapse high. Immunotherapy with dendritic cell (DC) vaccines after chemotherapy was shown by others to provide clinical benefit to some AML patients (van Tendeloo et al. 2010). Here we report results in four AML patients receiving DC vaccines targeting the antigens Wilm9s tumor-1 (WT-1) and preferentially expressed antigen in melanoma (PRAME), applied in compassionate use, employing new generation monocyte-derived fast DCs, matured with a cocktail containing the TLR7/8 ligand R848. The mature DCs show high expression of CD83, strong up-regulation of HLA-DR and co-stimulatory molecules, down-regulation of CD14 and polarized release of IL-12p70, with no or low IL-10 secretion, upon T cell encounter. After informed consent and hematopoietic recovery from chemotherapy, mononuclear cells were collected by apheresis and mature DC vaccines were prepared to separately express full length mRNA encoding the two target antigens (Subklewe et al. Cancer Immunol. Immunother. 2014). DCs were administered intradermally, once weekly for 4 wks, at wk6 and then on a monthly basis. Blood and bone marrow (BM) samples were collected throughout treatment. Minimal residual disease (MRD) was measured in BM and blood by quantitative PCR of WT-1 expression and BM was monitored by morphology. Table 1 summarizes the salient features of the patients, treatment parameters, MRD monitoring and initial immune response assessment. DTH reactions were detected in all patients challenged with DCs at wk6. Immune responses of CD4 and CD8 T cells demonstrating intracellular interferon gamma (IFNg) expression were assessed by flow cytometry of PBL stimulated overnight with peptides spanning WT-1, PRAME, and hTERT and survivin as vaccine-unrelated antigens. Responses were scored positive when two-fold or greater frequencies of IFNg-expressing T cells were found compared to unstimulated controls. Patient (Pt.)CU030 and Pt.CU031 showed CD4 and CD8 responses to different test antigens. Pt.CU030 displayed strong and persistent CD8 responses to PRAME and a surprising increase in hTERT reactivity, potentially representing epitope spreading. The pt. continues to receive monthly vaccination and displays a low fluctuating WT-1 PCR signal in BM but no signal is seen in blood at wk61 after start of vaccination. Pt.CU031 displayed WT-1-specific immune responses until wk37 when responses decreased and WT-1 PCR signals increased in BM. The pt. developed Bell9s palsy and immune responses were no longer detected after cortisone therapy. WT-1 signals then increased strongly in BM, accompanied by an increase of blasts. Pt. CU033 had no significant T cell response during 9 months (m) of vaccination. WT-1 signals now increase slowly in BM but relapse cannot be confirmed by morphology and WT-1 PCR remains negative in blood. Pt.CU040 has only received DC vaccines for 5 m, remains in morphological remission and immune response and MRD monitoring are ongoing. These results show that fast, TLR-polarized DCs induce or enhance specific T cell responses in elderly and undertreated AML patients, with individual strengths and specificities. Preliminary assessments suggest that changes in MRD are related to increase or loss of vaccine-associated immune responses. Disclosures Eckl:Medigene Immunotherapies GmbH: Employment. Schendel:Medigene Immunotherapies GmbH: Employment, Equity Ownership, Membership on an entity9s Board of Directors or advisory committees, Patents & Royalties: for DC maturation cocktail. Kvalheim:Medigene Immunotherapies GmbH: Other: Scientific collaboration.


It is not uncommon to reduce the dose or to discontinue anticoagulant agents before tooth extraction in patients who are receiving anticoagulant therapy. However, dose reduction or discontinuance of anticoagulant agents can cause complications such as thromboembolism. Recent recommendations to maintain the usual dosage of anticoagulation regimens have increased the importance of developing reliable procedures for local hemostasis. We used cotton-type atelocollagen to fill tooth extraction cavities in 25 patients who were receiving anticoagulant therapy and evaluated its efficacy. The cavity was sutured in 11 patients, but no other specific procedures, such as hemostatic splints, were used. The thrombotest (TT) levels and PT international normalized ratio (INR) before the operation ranged from 10.2% to 40.2% and from 1.44 to 2.89, respectively. Except for one patient in whom the cotton-type atelocollagen was displaced, we successfully performed primary hemostasis in all patients. There was no problematic postoperative hemorrhage.


This educational resource is designed for educators in the Life Sciences learning areas. It provides an opportunity for learners in Grade 10 to engage in learning activities and explore meaningful ways of conserving a threatened or endangered species in their local environment. The focus species in this WOW! Pack is the Eastern Cape Rocky, Sandelia bainsii.


This article introduces a powerful ODE solver called the Taylor Center for PCs (http://www.ski.org/gofen/TaylorMethod.htm) as a tool for teaching and performing numeric experiments with ODEs. The Taylor Center is an All-in-One GUI-style application for integrating ODEs by applying the modern Taylor Method (Automatic Differentiation). The Taylor Center also offers dynamic graphics (including 3D stereo vision). After a brief review of the features of the Taylor Center, we consider instructive examples of ODEs in various applications and also several particular examples illustrating intricacies of numeric integration. The article therefore continues the thesis of Borrelli and Coleman [2] that awareness and caution are needed while interpreting the results of numeric integration. We offer practical ideas and advice on how to use the Taylor Center for teaching ODEs, and to increase the motivation and interest of students.


Hau culture(filial piety culture) contains long history tradition,abundant content origins,rational kernel composition,but is facing national realistic predicament that it is being weakened in the countryside.The traditional culture of filial piety is to play a role of important value and manifold functions in the construction of rural social stability and harmony,country family providing for the aged,the development of village spiritual civilization and so on,so carrying forward and glorifying Hau culture is the actual choice for the new village construction.


The influence of anthropogenic trace gas emissions on the global troposphere is controlled by both chemical and dynamical processes, and the interaction between them controls any long-range impacts. We use the FRSGC-UCI 3-D chemical transport model to quantify the effects of anthropogenic emissions from the developing countries of East Asia on neighbouring continents and on the global troposphere. We show how the coupling of chemistry and meteorology leads to the largest changes in ozone over North America and Europe in spring and autumn, and demonstrate that future increases in precursor emissions may be expected to have significant effects on background levels of ozone at a hemispheric scale.


solve the continent's severe economic difficulties, which make a mockery of all human rights. Years of IMF-propagated medicines are partly responsible for the present unrest in African countries. However, France's decision to stop propping up undemocratic regimes may have been partly responsible as well: this change in policy, announced at the Franco-African summit held at La Baule, June 1990, meant the end for Hissene Habre's regime in Chad, whichwas refused French militaryback-up and swept away by a rebel force a few months later. The Chadian example illustrates another aspect of Africa's dilemma's: on the one hand dependence on Western countries may provided necessary support for the process of democratization, while on the other hand it may consolidate African dependence on outside forces, leaving the evolution towards democracy and the rule of law in a vulnerable state. What is certain, however, is that despite the slow beginnings of the African Commission on Human and People's Rights, political and civil liberties will remain on African government agenda's for some time. Meanwhile, the promotion of human rights is primarily a responsibility of national NGO's (April 1991).


This chapter discusses the centrality of the invisible church for Bunyan and his readers. Called to lead the Bedford congregation in 1671, Bunyan was committed to defending and building the visible church, but its purpose was to nurture souls on the pilgrimage to heaven, the invisible church of glory whose members were known only by God. Doctrinal works on the theology of justification, polemical works on 'things indifferent' (such as baptism) or on essentials of faith, and pastoral works on the spiritual conditions of his readers, all attest to Bunyan's single-minded focus on the invisible church in the 1670s. Religious toleration, like the visible church, was not a good in itself but a means to an end: the 'desired countrey' of union with God, the imagined community outside of time that made the present an interval of remembrance and anticipation.


Whereas the old cars required only a few electrical motors, the modern demand for comfort and safety, from air conditioning to ABS brakes, requires an ever-increasing number of small motors per vehicle. The car industry produces and consequently uses each year several hundreds of million motors of a few hundred watts. In these conditions, optimization is and will be an important issue for automobile equipment suppliers. In Part I of this article, authors have presented an analytical model for prediction of DC PM commutator motor performances on an operating range. The relevance of its results has been validated by comparison with experimental results and allows to implement it in an optimization procedure. This optimization is the main goal of this second part.


We used a multiplex nested-PCR assay for the simultaneous detection in cerebrospinal fluid (CSF) of fivehuman herpesviruses (HVs) (cytomegalovirus [CMV], Epstein-Barr virus [EBV], varicella-zoster virus [VZV],herpes simplex virus [HSV], and human herpesvirus 6 [HHV-6]) in a clinical evaluation of human immuno-deficiency virus (HIV)-infected patients with neurological disorders. This method, which has the advantages ofbeing rapid and economical, would be of particular interest for the diagnosis of neurological syndromes causedby more than one HV. We studied 251 CSF samples from 219 patients. HV DNA was demonstrated in 93 (37%)of the CSF samples (34% of the patients). CMV was the HV most frequently detected in our patients (25%),while EBV, VZV, HSV, and HHV-6 DNAs were present in significantly fewer cases (7, 4, 3, and 1%, respec-tively). When results were compared with the final etiological diagnoses of the patients, the multiplex HV PCRshowed high specificity for the diagnosis of CMV and VZV neurological diseases and for cerebral lymphoma(0.95, 0.97, and 0.99, respectively). The sensitivity of the assay was high for CMV disease (0.87), was low forcerebral lymphoma (0.33), and was not evaluable for VZV disease due to the small number of patients with thisdiagnosis. Nevertheless, detection of VZV DNA had possible diagnostic value in four of the nine cases, and EBVDNA amplification always predicted the diagnosis of cerebral lymphoma in patients with cerebral masses.Detection of HSV DNA was frequently associated with CMV amplification and fatal encephalitis. HHV-6 wasnot considered to have a pathogenetic role in the three cases in which it was detected. This multiplex HV PCRassay is a specific and clinically useful method for the evaluation of HIV-infected patients with neurologicaldisorders related to HV.


The present invention relates to through complete equipment bone insertion of the suture. This device comprises a body (1) for supporting the protruding cannula (3) having a working end (30), the device is a flexible thread-like elements (4), sharpened tip (40 ), and at least one suture (opening that functions to pass 5) (41) is formed, is accommodated so as to slide coaxially within the cannula (3), based on the instruction, the cannula working end exits (30), provided with a thread-like element which is assumed curved position, the instrument, a first means for the two directions with respect to the cannula (3) generates a coaxial movement of the thread-like elements (4) If, comprising second means for generating a coaxial movement of the thread-like elements in the direction out of the cannula (3), and in a short time, the movement generated by the second means, threadlike element generated by the first means It is released from the forward. .Field


ABSTRACT The objective of this study was to report our experiences using the layered closure technique for obstetric-related old complete perineal lacerations. This was a retrospective study that identified all patients who underwent surgical correction for a defect that was obstetric-related and involved complete or near complete disruption of the perineal body and external anal sphincter. Thirty-one patients were included for analysis. Two patients each had undergone one prior attempt at repair. The mean interval from the time of laceration or previous repair to the repair was 26 months, with a range of 8 days to 15 years. Five patients underwent repair at the time of a subsequent vaginal delivery. Two patients underwent early repair for what was essentially a dehiscence of a fourth-degree episiotomy. Twenty-six of the 31 patients (84%) healed uneventfully and remained completely continent. The remaining 5 patients had some element of breakdown of the repair. Factors that may have contributed to failure...


Million tons of walnut shells, the waste by-product from walnut industries, are produced annually worldwide and are under-utilized in kernel manufacturing. Walnut shells are rich in phenolic compounds thus are valuable sources for antioxidants. In this study, the optimization of ultrasound-assisted extraction of phenolic compounds from walnut shells was performed with response surface methodology (RSM). The maximum yield of total phenolic compounds from walnut shells was 92.96±1.47 mg GAE/g DW under the optimum extracting conditions of 10 min at 0°C with 43.71% ethanol and 53.93% ultrasound amplitude. Analysis of antioxidant activities of the extracts found that the radical scavenging capacity of DPPH from the walnut shell extracts (10 - 500 μg/mL) was 4.05 – 88.59%, while the ferric reducing antioxidant power (FRAP) (10 - 100 μg/mL) was 119.64-1278.95 μM Trolox equivalent (TE). The results indicate that phenolic extracts from walnut shells are a good natural source of antioxidants, making this process a strong contender for future applications in the food and agricultural industries.


Framboid microcrystals, which are intrinsically similar in size and habit within any individual framboid, must have all nucleated and grown at the same time. The formation of many thousands of equidimensional and equimorphic microcrystals in framboids is the fundamental evidence for burst nucleation. This is conventionally described by the LaMer model, which is characterized by (1) a lag phase before nucleation becomes significant; (2) burst nucleation where the rate of nucleation increases exponentially and may be completed in seconds; and (3) a short growth phase where nucleation becomes again insignificant. The growth phase is limited by the diffusion of Fe and S in stagnant, diffusion limited environments. By contrast, individual pyrite crystals evidence isolated nucleation and unlimited growth in advecting systems. The reaction with surface =FeS provided by sulfidized iron oxyhydroxides may a major route for producing individual pyrite crystals, rather than framboids, especially in sediments. Framboid formation by the nucleation of pyrite in solution can be described by classical nucleation theory (CNT), which leads to results consistent with observed critical supersaturation ranges, critical nucleus radius, and surface energies.


The entirety of any organism is achieved primarily by the regulated expression of the components of its genome. We are the phenotypic result of our genotypic expression. That is, our gene products are integrally responsible for the physical, intellectual and behavioral traits that identify us as individuals. Genes are hereditary material composed of nucleotide sequences that code for the synthesis of proteins that are either structurally or metabolically active in living tissues. The tight regulation of gene expression is innately programmed and responsible for the intricately detailed assembly and function of the biological systems that make up an organism. When the balance of our gene expression is distorted by outside influences or internal mishaps, the resulting malaise is commonly known as disease. Such alterations of the gene sequence or of the regulation of gene expression may result in protein products that either do not function properly or are not manufactured at all. The mutated or absent proteins may upset the normal activity of the cells and lead to the expression of an illness. Scientists have thoroughly dissected many diseases in attempts to develop therapies that either compensate for defective gene expression or that interfere with disease mechanisms. Current treatments often consists of oral drug administration to deliver temporary symptom relief. Many obstacles such as harmful side effects, drug resistance, cost and addiction associated with long-term use often accompany such therapy. In the search for more efficient and permanent alternatives, scientists are studying the potential use of viral vectors as a vehicle for gene therapy.


Given the uncertainty in the timing, location and magnitude of future earthquakes, for most engineering purposes it is most meaningful to use a probabilistic approach to characterizing the ground motion that a given site will experience in the future. A probabilistic seismic hazard analysis takes into account the ground motions from the full range of earthquake magnitudes that can occur on each fault or source zone that can affect the site. The probabilistic approach is very compatible with current trends in earthquake engineering and the development of building codes, which have embraced the concept of performance based design. In contrast to the traditional building code approach, performance-based design requires an explicit prediction of the structure's performance at each of several ground motion levels corresponding to a set of performance objectives. Each performance objective is associated with an annual probability of occurrence, with increasingly undesirable performance characteristics caused by increasing levels of strong ground motion having decreasing annual probability of occurrence. Performance based design requires a more comprehensive representation of ground motions than has conventionally been used. For example, ground motions estimates are needed at multiple annual probability levels, and may need to be specified not only by response spectra but also by suites of strong motion time histories for input into time-domain non-linear analyses of structures, because response spectrum analysis is based on a linear elastic model and therefore does not address the non-linear response that is the essence of building damage and failure.


The utility model provides a logging tool calibration device and a system with the device, wherein, the device comprises an axisymmetric circular column tank, an inner column surface of the tank forms a vent hole, the tank has salt solution inside, a throttle press-out device is arranged inside the tank. The system comprises the logging tool calibration device and a circulating system of the salt solution inside the device, wherein, the circulating system is provided with a circulating pump and a circulating pipe which is connected with the circulating pump, one end of the circulating pipe is connected with a solution inlet of the logging tool calibration device, while the other end of circulating pipe is connected with a solution outlet of the logging tool calibration device. The device and the system of the utility model can more accurately process a calibration to the logging tool.


A multi-layered discourse analysis of the interaction of three to five-year-old children in two preschools reveals a highly structured process occurring between the children and their caretakers to build and maintain joint attention. This process, serving to promote socialization into preschool, is constructed through language, gaze, intonation, and physical embodiment.


This research tested the interactions among organizational learning culture, leadership styles, climate for innovation, and marketing concept of sports clubs in team sports. The study included elite sport managers (N=118), from four team sports (football, basketball, handball, and volleyball), who participated in the highest rank of national competition in Serbia. The organizational learning culture was measured with attitudes of respondents about the organizational learning culture at individual, team or group level, and organization as dichotomous variables, while leadership styles used the MLQ self-assessment questionnaire. The climate for innovation scale was measured with scales for assessing organizational support for creativity, maladaptation, support for innovation, and resource supply. The presence/absence of components of the different marketing mix aspects was measured as a four-dimensional variable for evaluation marketing concept. The results supported the mediation and path models. Direct effect to variable marketing concept is noticed only in the organizational learning culture, while climate for innovations and leadership style did not have a direct effect on the marketing concept. Indirect effects revealed that the status of the sports branch, the market position of each club in its sport competitive results, and the education background of managers' impact marketing concept in team sports in Serbia. The theoretical and practical contributions of obtaining results are discussed.


The invention discloses a PET film with a two-layer structure and a solar cell backboard comprising the PET film. An outer PET film and an inner PET film are subjected to bidirectional stretching co-extrusion to form the PET film with a two-layer structure. The PET film has small thickness, a high rate of heat dissipation, a high reflecting rate and long-term aging resistance. The PET film with a two-layer structure is used as a base layer, and an adhesive layer and an insulation film layer are bonded at a side of the base layer so that the solar cell backboard is formed. The PET film has excellent insulation, heat radiation, heat resistance, mechanical properties and water-blocking properties. Compared with the existing solar cell backboard, the solar cell backboard comprising the PET film has better heat resistance, weatherability and water-blocking properties, has a simple structure and can be repaired easily.


In 2002 Quebec's National Assembly hosted an international conference on the history of parliamentary libraries. On that occasion, Gaston Bernier called for more research on the history of parliamentary libraries , inviting researchers to make use of the rich and unexplored archives of parliamentary libraries throughout the world (2003). This historical overview features some of the most prominent parliamentary libraries in the world, their evolution, and the collections and services the institutions provide to their constituencies. Parliaments are assemblies of elected representatives, usually of an entire nation, that have supreme legislative powers within a particular state or country. The distinctive qualities of different types of parliaments may be explained by the varying historical contexts in which countries have established their parliaments. Systems of parliamentary government vary according to the constitutional role assigned to the parliament and the electoral and party systems that determine their composition and political organization (McLean, 1996). Parliaments are an expression of democratic values. Democratic parliaments should be representative, transparent , accessible, and effective. In order to fulfill these characteristics, parliamentarians need access to up-to-the-minute unbiased research and information facilities. A well-resourced parliament, such as is typical in developed economies, will have, inter alia, a comprehensive library and information service (Beetham, 2006). Parliamentary libraries (also known under various terminologies such as federal libraries, legislative libraries, information resource centers, documentation centers, or reference services) enhance the research and information capacity of parliaments. As their histories show, however, some also came to consider their constituencies as lying beyond the confines of their parent legislature.


For most of Southeast Asia the Cold War was over by 1980. Communism was a failed system and, with the exception of the Indochinese countries, governments of Southeast Asia were satisfied with die Western model of development. One could say that die last vestiges of die Cold War eased out of Soumeast Asia when Vietnamese troops left Cambodia. Given the relative success of the Soutiieast Asian economies, one might think diat peace and progress had come easily to Soumeast Asia. But diese are still fragile commodities. As major issues are resolved, residuals remain.


The Petri dish tests revealed that 500-fold Polyhydroxy Dinaphthaldehyde wasn′t capable of inhibiting effectively hypha growths of many pathogen fungi, Gerlachia nivilis (Monographeva nivalis), Gaeumannomyces graminiss, Venturia pirina, Alternaria Solani, Phytophthora capsici, Glomerella lagenaria and Fusarium oxysporium, otherwise, it promoted a few pathogen fumgo to grow weakly, such as Gibberella zeae, Cochliobolus sativus and Rhizoctonia cerealis. This same density of polyhydroxy dinaphthaldehyde also may control strongly cucumber downy mildew disearse caused by Psedudoperonts pora cubensis, furthermore cucumber hosts can much rapidly reproduce after they are treated with polyhydroxy dinaphthaldehyde solution, but its protection activities were inferior to carbendazim.


In this paper we studied the link between economic growth and the environment. We discussed the inverse U-shaped relationship between environmental pollutants and economic growth. First, we analyzed the long-term observation of the growth of CO2 emissions which is characterized by three phases. Second, we estimated the EKC curve for Tunisia. The results of our estimates revealed a problem of autocorrelation of errors which we solved by using the Cochran-Orcutt method. The model was corrected for ρ = 0.4. In addition, we noticed that the Durbin-Watson model without the dummy variable is better than the model that incorporates the dummy variable. This finding confirmed the existence of an inverted U-shaped CEK. Our results show that the country has not yet reached the threshold of development from which economic growth is accompanied by a reduction of pollutant emissions. More precisely, the value of GDP* is $2062,647 which is much lower than the $8,000 found by Seldon and Song (1994) characterizing the reversal point of the inverted U curve. Tunisia is therefore in the phase where an increase in GDP is accompanied by a deterioration of the environment.


This article introduces the Viikki eco-neighbourhood in Helsinki, summarizes the eco-efficiency of the green building in the community,compares and analyzes the special eco-criteria , greenscore system and eco-management of the Viikii.


OBJECTIVE To study the preparation method of liposome loaded with docetaxel(Doc) and antisense oligodeoxyribonucleotide(ODN).METHODS The liposomes were prepared by ethanol injection method,evaluated with entrapment efficiency and particle diameter and the center combination design.The particle size was determined by nano series.The entrapment efficiency of Doc was determined by HPLC and ODN was labeled with FITC for the entrapment efficiency determination.RESULTS The optimal formulation was phospholipids-cholesterol(3:1),the ratio of drug to lipid was 1:50,Chol-DC-Chol(2.4:1),the content of Chol-PEG2000 was 8%,the entrapment efficiency of Doc and ODN were 50%-60% and 60%-70%,respectively.CONCLUSION The liposome loaded with Doc and ODN was successful prepared by ethanol injection method.


Blood cell production is one of the major limiting effects of cell-cycle-specific chemotherapy. By studying the effects of the drugs on a mathematical model of hematopoiesis, a better understanding of how to prevent over-reduction of circulating blood cells may be investigated. In this model we will use a delay-differential equation developed by Mackey and Glass (1977) to show acceptable chemotherapeutic doses (i.e. survival of the circulating blood cells) as a function of: the period which the drugs are administered: the strength of the dose; and the delay from initiation of blood cell production to its release into the blood stream. We then make qualitative comparisons to known effects of cell-cyclespecific chemotherapy on circulating blood cell elements. Finally, we also consider how the effects of hematopoietic growth factors alter the outcome of the therapy.


A review of the elements of microwave spectroscopy as it concerns, or is likely to concern, radio astronomy is presented. This review attempts to show how atomic and molecular resonance lines arise in the radio frequency spectrum and to discuss the important parameters of spectral lines. Finally, it is shown how the intensity of radio emission received from the galaxy is modified by the presence of an interstellar atomic gas having a resonance transition at the frequency of observation.


Bi_2(Zn_(1/3)Nb_(2/3))_2O_7 based ceramics were prepared by a traditional solid phase reaction method.The effects of substitution Na~+ for Bi~(3+) and Ni~(2+) for Nb~(3+) on the sintering and dielectric properties of Bi_2(Zn_(1/3)Nb_(2/3))_2O_7 based ceramics were investigated.The sintering temperature of the substituted samples dropped to 870℃from 960℃.At -30℃-+130℃,the dielectric relaxation peak with a broad temperature region is obviously observed and two relaxation peaks appear when the substitution of Ni~(2+) reaches 0.2.Then,with the increasing of substitution, the temperature of the permittivity maximum shifts to higher temperature and the activation energy involved in the relaxation processes increases and the distance between two relaxation peaks become longer.Defect dipole and distortion of crystal lattice theories are used to explain the dielectric relaxation of Na-Ni doped Bi_2(Zn_(1/3)Nb_(2/3))_2O_7ceramics.


Serum samples were collected from Datong Cattle Farm and Haiyan county in Qinghai province from March to May in 2010 to investigate the prevalence of viral diarrhea/mucosal disease and infectious rhinotracheitis in yaks.The yak serum samples were tested by quantitative enzyme-linked immunesorbent assay(ELISA).Out of 111 yak serum samples collected from Datong Cattle Farm,26 samples(23.42%) were detected positive and 9 samples(8.11%) undetermined for viral diarrhea/mucosal disease while 72 samples(65.45%) were positive and 8 samples(7.27%) undetermined for infectious rhinotracheitis.Among 141 yak serum samples collected from Haiyan county,28 samples(19.86%) were detected positive and 15 samples(10.64%) undetermined for viral diarrhea/mucosal disease while 7 samples(4.96%) were positive and 3 samples(2.13%) undetermined for infectious rhinotracheitis..


In the modern theory and practice of international investment law on forced removal of foreign ownership, the issue of indirect expropriation remains topical. Despite the fact that the term "indirect ("creeping") expropriation" is not legally secured, it is actively used both in the doctrine and arbitration practice. Analysis of judicial practice shows that the courts tend to develop and specify the signs indirect expropriation of foreign property so that eventually they could be fixed in the international regulatory system. International arbitration courts are trying to establish a fair balance between the rights of investors and the rights of the state to regulate.


This paper proposes three techniques for locating lightning strikes in a 115 kV transmission system over 88.5 km, based on the arrival time of a transient wave obtained from a discrete wavelet transform (DWT). The first technique calculates the location based on the 'type D' travelling wave method. The second technique analyses the first arrival time and same reflected-back wave arrival time between two substations. In the third technique, two sensors are installed to record arrival times at each sensor. Case studies of direct lightning strikes to phase conductors (shielding failure) are simulated using the 'Alternative Transients Program/Electromagnetic Transients Program' (ATP/EMTP). The influences of three parameters are considered: inception angles, the phase of the conductor, and the position at which the lightning struck the transmission system. By performing an operation scheme for all techniques, a positive sequence current is calculated, using a three-phase current from the ATP/EMTP program which is converted using Clark's transform. A positive sequence current is extracted to several scales using the DWT, and the orders of arrival times for both substations are determined. After the arrival times are obtained, each technique uses a different order of arrival time for calculating the lightning location. By comparing the average error among the three techniques, it is shown that the arrival time of the two sensors' technique is less than that of the other techniques.


OBJECTIVE:To investigate the effect of genetically modified adenovirus H101 on nude mice model of human osteosarcoma. METHODS:Incubate OS-732 cell line on 29 nude mice were divided into treatment group and control group. The genetically modified adenovirus H101 was injected into the primary tumor in the treatment group and DMEM was injected intratumorally in the control group. Observe the mean diameter and the wet weight of the primary tumor and the distant metastasis. Calculate the lung metastasis nodules and the total metastasis nodules. They were also analyzed by FCM. RESULTS:There were no significant differences with the mean diameter,wet weight and the aneuploid percents of the primary tumors and the distant metastasis tumors between the treatment group and the control group (P0.05). The lung metastasis nodules of the treatment group and the control group were 4.20±2.33 and 3.57±2.20,respectively. There were no significant differences(t=0.745,P=0.463); The total lung metastasis nodules of the treatment group and the control group are 11.00±6.43 and 9.57±6.17,respectively. There are no significant differences (t=0.611,P=0.547).CONCLUSION:The genetically modified adenovirus H101 can not inhibit the growth and metastasis tendency of the osteosarcoma in this nude mice model.


Abstract : A study of the F-layer of the ionosphere made with an HF backscatter radar using a narrow-beam antenna has revealed a large number of irregularities in the size range from 50 to 500 km in north-south extent. It was possible to divide these irregularities into 5 types which were named spot, line, split, step, and range variable. On the basis of 60 one-hour records, the probability of the occurrence of each type was estimated (spot: 60%; split: 90%; others: less than 20% of the time). North-south motion of the irregularities was observed, but it occurs less than 10% of the time and always with movement from north to south. When observed, the average velocity of movement is of the order to 1000 km/hr. On occasion, growth and fade of the irregularities was noticed, with the time from start of growth of time of fade-out being of the order of 10 to 15 minutes.


This study aimed to examine the dynamic response of large converters to the braking process. Based on the rigid–flexible coupling theory of the multi-body dynamics, and by adopting the finite element method and multi-body dynamics software Recurdyn, this work constructed a variety of rigid–flexible coupling dynamic models of converter transmission systems. With torsional vibration of the converter furnace during braking as the object of analysis, this research studied the pattern of the impact of speed change of driving motors, braking time, and rotational damping of the system on the torsional vibration characteristics of converters during the braking process. Comparison of the simulation results indicated that the rigid–flexible coupling mode had a greater impact on the simulation results and simulation efficiency. In particular, the analysis model using elastic units in the coupling between rigid and flexible bodies could effectively simulate the torsional and vibrational response of the converter braking process. Dynamic simulation results showed that increasing the braking time and rotational damping of the driving motor could effectively reduce the torsional vibration of the furnace under certain conditions. Within the same braking time, the maximum value and the continuity of the driving motor acceleration had the greatest impact on the torsional vibration amplitude of the furnace, and optimal control of furnace torsional vibration could be achieved when the acceleration was a second-order curve.


The subject innovation is this as a device for precise putting practice, putting lines narrow and also to reach the end portion of the accurate adjustment of the alignment, or putting the power of a putter or a line target bar by which line bar (bar) projecting to a predetermined height hayeoseo to fall to either side before rolling has an effect that allows you to check and correct wrong information reaches the hall cup