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Hot on the back of October's bumper local scene report and gig guide from Nottingham and the East Midlands, comes the seventh and final installment from DiS' man in the city for 2011...
So, when all's said and done it's turned out to be a pretty fantastic year for Nottingham and its music scene. The rise of Dog Is Dead to Radio 1 playlists and major label status via a relentless schedule of live shows tells its own success story. Having established themselves as one of the country's brightest young bands, 2012 looks set to be just as hectic with the band heading out on their biggest headline tour to date throughout February and March, followed by the release of their as-yet untitled debut long player later in the year. This coming weekend sees them headline their biggest ever show to date at Nottingham's Rock City, with support coming from up-and-coming local outfit Kappa Gamma among others. In the meantime, Dog Is Dead have also joined in with the seasonal festivities by recording a version of The Waitresses 'Christmas Wrapping', the video of which is at the bottom of the page.
Elsewhere, both Spotlight Kid and Swimming have put out excellent second albums this year. On top of that, Hhymn's fantastic debut In The Depths coupled with the Origamibiro long player Shakkei has gained local independent Denizen Recordings national recognition, with the promise of more to come next year from the likes of Injured Birds and the aforementioned Kappa Gamma. We're also expecting new material from Fists, We Show Up On Radar and Red Shoe Diaries in the none-too-distant future while motormouth extraordinaire Sleaford Mods has provided a taster for what to expect on his forthcoming album with the intriguingly titled 'Shit Streets Runny'.
On top of that, we're hearing that legendary garage punks The X-Rays have reformed with the promise of live shows next year, while hotly tipped four-piece Frontiers finally look set to release their first record in the coming months. Of course there's also Dot To Dot, Splendour, and Headstocks festivals to look forward to next summer, which can only make 2012 just as exciting a prospect as its predecessor.
Finally, celebrating over thirty years of excellent music from the city and its surrounding towns, here's the Nottingham Spotify playlist to end all playlists. Merry Christmas and a Happy New Year!
As is usually the case at this time of year, there's very little in the way of releases to tell you about, so instead we'd like to introduce you to five local artists expected to make a big impression over the coming months.
One such artist that has caught our attention in recent times is singer/songwriter Owen James Harvey. His fusion of country, folk, Americana and soul makes for a refreshing listen, and earlier this year he flew out to Nashville to record a six-track EP, which was released last week (5th December) and is available to purchase here. Having launched the EP at Camden's Blues Kitchen earlier this month, 2012 looks set to be a promising year indeed.
Remember Wolves (Of Greece)? Or Reynolds? And who could possibly forget Lords? Well meet Grey Hairs, a band featuring players from the aforementioned and more besides. Here's a clip of their brutal post-hardcore assault at its finest.
Grey Hairs 2 from Chris Summerlin on Vimeo.
In the meantime, those excellent purveyors of taste at Gringo Records have put together this excellent 12-track compilation featuring the likes of I'm Being Good, That Fucking Tank, Hookworms and many more besides. Even better, it's free, and can be downloaded via the link below:-
In Isolation call themselves "Noir Wave" having been influenced by the more underground post-punk sounds of the 1980s. Forthcoming single 'Film Noir Scandal' should be out in the early part of 2012 having been produced by Gavin Monaghan whose past credits include Editors among others, while they're also scheduled to appear in feature-length movie 'Zombie Hood' next year as well as contributing several songs to the soundtrack. One of which, 'The Wrong Girl', can be seen and heard below. As well as playing in the band, singer/guitarist Ryan Swift also runs the Dark Edge club night which we wholeheartedly recommend.
As well as playing with the excellent Injured Birds, multi-instrumentalist David Keye is building a reputation as an esteemed composer in his own right, as demonstrated on recent five-track EP 'Grace Of States'. Recorded entirely as solo piano pieces, it's an evocative, captivating collection of songs that once again serves to highlight another blossoming talent from the city.
Finally, 21-year-old Nottingham born singer/songwriter Rob Green is another name to look out for in 2012. Although currently based in Leeds, his recent show at the Bodega attracted a host of plaudits from those in attendance. Also a trained actor, his debut single 'Cardinal' is set for release on 13th January next year, and we're predicting big things.
16th December - Sleaford Mods + Grey Hairs + The Pushrods - Chameleon
17th December - Dog Is Dead + Tribes + Kappa Gamma - Rock City
17th December - Swimming + Fists-o-maza + Hhymn + August Actually + Unique Movements + many more... - Damn You! Xmas Covers Party @ Bodega Social
17th December - Earthtone 9 + Illuminatus - Rescue Rooms
19th December - Friendly Fires + Chad Valley - Rock City
20th December - Crazy Arm - The Maze
31st December - Baby Godzilla + Hot Japanese Girl + Captain Dangerous - The Maze
4th January - Great British Weather + The Conifers - The Maze
10th January - Band Of Jackals + Heroes Of Switzerland - The Maze
20th January - Shield Yr Eyes + I'm Being Good + Grey Hairs - Chameleon
20th January - Great British Weather + The Amber Herd + Lisa De Ville - The Maze
21st January - Gwar + Viking Skull - Rock City
23rd January - Dave McPherson (InMe) - The Maze
28th January - Wild Flag - Rescue Rooms
28th January - Arse Full Of Chips - Rock City Basement
31st January - Howler + Man Made - Bodega Social
If anyone has any Nottingham based bands, gigs, releases, links, events or clubnights to add they feel have been unjustly overlooked please do so in the comments section below.


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JulietteMcQueen video. All videos (4)JulietteMcQueen webcam
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Hey there! My name is Juliette, a sweet blonde with a smile to die for ;) and big perfect breasts. I love long tease, erotic talk , soft touches, and deep pleasure. I`m a smart girl with sexy body. Join me and discover me, you will be totally satisfied!

subset: commoncrawl


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Healthy & Delicious: Parsnip Soup with Vanilla Recipe
Healthy and delicious recipes from Serious Eats
Editor's note: On Mondays, Kristen Swensson Sturt of Cheap, Healthy, Good swings by these parts to share healthy and delicious recipes with us. Take it away, Kristen!
Frequently overshadowed by more colorful produce, the humble parsnip deserves more props than it often receives. The slender, goldenish root vegetable possesses the sweetness of a carrot and a slight starchiness that suggests a potato, all while packing a nice little nutritional punch. A good source of potassium, parsnips are also high in fiber, as well as vitamins C and K. They're much easier to peel than rutabagas, too. So there's that.
Unbeknownst to most, the parsnip has a secret weapon in its vast cache of, y'know, weapons that are less secret. It complements a stunning range of flavors. Sweet, savory, spicy - you name it, and the parsnip goes with it. Take vanilla, for instance.
Adapted from Marco Canora's Salt to Taste, the very-simple Parsnip Soup with Vanilla has a grand total of six ingredients: water, salt, pepper, butter, parsnips, and half a vanilla bean. Though the vanilla is always discernable, and becomes more assertive as the dish sits, it never overwhelms the parsnippy goodness. I've made the soup three times in the last three weeks, and plan on making it again soon.
One recipe note: Try to use parsnips with slender tops, since thicker parsnips possess woody cores that might have to be strained out. Otherwise, all you need is a knife and a pot, and you're golden. Just like your parsnips.
- Yield:4
- Active time: 10 minutes
- Total time:80 minutes
- Rated:
- 2 pounds parsnips (not too thick at the top), peeled and chopped into 1-inch chunks
- 8 cups water
- 1/2 vanilla bean
- 2 or 3 tablespoons unsalted butter
- Kosher salt and freshly ground black pepper
In a large Dutch oven, combine parsnips and water. Scrape seeds from vanilla bean and add to Dutch oven along with the husk itself. Bring to a boil. Reduce to a simmer and cook for 60 minutes. Remove vanilla bean husk. Add butter to soup, then using a blender or an immersion blender, carefully puree soup, in batches if necessary. If soup is too thick, add water until it reaches desired consistency. If soup is too thin, simmer to reduce until it reaches desired consistency. Season to taste with salt and pepper.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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"A surefire fix for fans of Kleenex and Delta 5…" - J. Edward Keyes, Magnet "A witch's brew of The Vaselines, surf and 60's garage… The Fuzzbox-esque half sweet, half swaggering 'It's Hip' and surfy 'The Man with the Spiked-Toed Shoes' could have been one of Rough Trade's finest hours." - Ed Zed, Rock Bottom
And from back in the day... "'Shell Shock'…is hypnotic, dark and intense. Nearest comparison (intended as a rough guide, not to define/confine) might be Velvet Underground." NME, 1980.
"[The Terraplanes] deserve to be HUGE" - Mick Mercer, Zig Zag 1981
Messthetics' first "solo" act re-emerges with vastly-improved sound and four songs from a hitherto lost 1979 session that rank with their very best, making for well over an hour of music. 12-page booklet with extensive notes, new photos and A+M ephemera, plus a traditional (and extremely handsome) H2D cover with a real photo.
$11.00 - includes live 1981 video of "Evil Going On."
'Terraplane Fixation'
'The Suspect'
'Terminal Beach'
'I Never Worry'
Copyright © 2020 Hyped to DeathPowered by osCommerce


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Non-stick, non-abrasive support fabric for fragile papers during conservation treatments. Used as an interleaving material when drying photographs, papers & textiles. The porous weave allows water to pass thru while the support fabric retains its strength. Pre-cut sheets for washing trays & tables, rolls for larger projects.
Hollinger Metal Edge Inc
9401 Northeast Dr.
Fredericksburg, VA 22408
Phone: 800-634-0491
Phone: 540-898-7300
Fax: 800-947-8814


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Document Actions
The Department of Africana and Puerto Rican/Latino Studies is an interdisciplinary program in the School of Arts and Sciences. The curriculum of the department, which offers courses in the humanities and social sciences, is devoted to the exploration and analysis of the history and culture of two heritages: the heritage of African people in the Americas, the Caribbean, and Africa; the heritage of Puerto Ricans; and the broader Latino experience in the United States. The multidisciplinary curriculum and the duality of heritages make the structure of the department unique and its curricular offerings challenging. Where it is applicable, the similarities and experiences of the two societies are emphasized but, generally speaking, the curriculum treats the two sequences as separate entities attempting to offer students of all backgrounds an alternative approach to the prevalent Eurocentric perspective.
- Learn more about Africana Studies >
- Learn more about Puerto Rican/Latino Studies >
- Program Learning Outcomes >
Administrative Assistant:
Ms. Barbara Saunders


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Reading a recipe aloud
Reading aloud is shown to improve confidence and understanding.
Cooks often use a wok to cook Chinese food, especially stir-fry. TV chef Ken Hom shows us a tasty way to make dish of Chinese vegetables in a wok.
In Britain, chips are a national favourite. Celebrity chef Heston Blumenthal tells us his recipe for making perfect chips.
If you're interested in cooking or working in a restaurant or cafe then try these vocabulary exercises to learn words about the kitchen.
Do you like making cakes and biscuits? Watch this video where Anne shows you how to make some traditional British biscuits. They taste so good!
How do you tell someone what you want them to do English? Do other people tell you what to do?


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Regular Price:
Special Price
• Baltic Blue Suede and Gold Metallic Suede
• Inner and Outer Sole : Leather
• Made in Spain
You can choose your usual size for the Supernova shoe unless you have slightly wider feet, in which case go for a half-size larger.
Before using your suede shoes apply a waterproof spray. Repeat the process on a regular basis, at least every seven times you wear them. This will protect your shoes and keep them as new. Avoid prolonged exposure to sunlight and water. In case of slight color loss, it is recommended to use a restorer spray matching the color of your shoes. Don't hesitate to bring them to a shoe cobbler as many times as necessary.
You must take out the protection film on the soles before wearing the shoes and only when you are sure you are not going to request a reimbursement.
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De l'amour dans votre boîte mail chaque mois
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A Sandwich a Day: Lazio at Sergimmo Salumeria
A new sandwich every day.
In this great city of ours, one could eat a different sandwich every day of the year—so that's what we'll do. Here's A Sandwich a Day, our daily look at sandwiches around New York. Got a sandwich we should check out? Let us know. —The Mgmt.
The sandwiches at Sergimmo Salumeria are an ode to the Italian classic sandwich. If you're looking for a slight twist on the usual, take a bite out of the Lazio Panini ($9). Thinly sliced layers of smoky, spicy chorizo make up the heart of this sandwich, while snappy pieces of provolone lace the meat with a mild buttery flavor. When paired with Sergimmo's balsamic dressing, the spread of black olives adds a surprisingly sweet cap to an otherwise salty sandwich filling. A handful of greens tops it all off with a little freshness before getting packed into a perfectly springy and crusty baguette.
Sergimmo Salumeria
456 9th Avenue, New York, NY 10018 (map) 212-967-4212


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(WXII/CNN) - A 3-year-old girl who has been the focus of an Amber Alert for more than a day has been found alive and well, officials said.
Greensboro police said Ahlora Lindiment was abducted by a woman while at a playground in an apartment complex. The Amber Alert was issued Wednesday night.
Police announced Ahlora had been found at a news conference Thursday.
Chief Wayne Scott said a woman called the police station's tip line just after 8 p.m. local time and said that she may have seen the girl at a church.
Officials found her standing alone in front of the church. She was reunited with her family and taken to a local hospital to be checked out.
Authorities are still searching for the suspect. Greensboro Police have identified her as N'denezsia Monique Lancaster, 22, of Greensboro.
Police said Lancaster is facing a charge of first-degree kidnapping.
"The obvious thing we need to do here is find this individual, determine what was the motive, what were the issues, and take our appropriate action up to and including any charges that may be relevant," Scott said. "We obviously want to try to find this individual, get them off the streets, and we don't have a similar issue to occur. This is very positive."
Authorities also released a surveillance image of the female suspect.
Witnesses described her as interacting in a suspicious way with children before leaving with Ahlora.
Copyright 2019 WXII via CNN. All rights reserved.


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UBS agrees to pay approximately CHF 1.4 billion in fines and disgorgement to US, UK and Swiss authorities to resolve LIBOR-related investigations.
As part of a proposed agreement with the US Department of Justice (DoJ), UBS Securities Japan Co. Ltd. (UBSSJ) has agreed to enter a plea to one count of wire fraud relating to the manipulation of certain benchmark interest rates, including Yen LIBOR.
UBS is making progress in risk-weighted assets (RWA) reduction in the fourth quarter and expects its fully applied Basel III common equity tier 1 ratio to be roughly in line with the third quarter's level of 9.3% , and net new money in UBS's wealth management businesses is expected to be positive.
UBS believes its fourth quarter net profit attributable to shareholders will show a loss, primarily as a result of provisions for litigation and regulatory matters.
Zurich / New York / London / Tokyo, 19 December 2012 – UBS AG announced today that its Board of Directors has authorized settlements with the US Department of Justice (DoJ) and Commodity Futures Trading Commission (CFTC) in connection with their investigations of benchmark interest rates. The proposed settlement with the CFTC is subject to the Commission's approval. UBS has reached a settlement with the UK Financial Services Authority (FSA) concerning its investigation. The Swiss Financial Market Supervisory Authority (FINMA) will also issue an order concluding its formal proceedings with respect to UBS.
UBS agrees to pay a total of approximately CHF 1.4 billion in fines and disgorgement. UBS will pay GBP 160 million in fines to the FSA and CHF 59 million as disgorgement of estimated profits to FINMA. The Board has authorized a payment of fines totaling USD 1.2 billion to the DoJ and CFTC, and expects those authorities to make further announcements later today. These monies would be paid according to specified payment schedules.
The conduct described in the settlements includes the following:
Certain UBS personnel engaged in efforts to manipulate submissions for certain benchmark rates to benefit trading positions;
Certain employees at the bank colluded with employees at other banks and cash brokers to influence certain benchmark rates to benefit their trading positions; and
Certain personnel gave inappropriate directions to UBS submitters that were in part motivated by a desire to avoid unfair and negative market and media perceptions during the financial crisis.
The conduct encompassed by the settlements includes Yen LIBOR, GBP LIBOR, CHF LIBOR, Euro LIBOR, USD LIBOR, Euribor and Euroyen TIBOR, although the nature and extent of the conduct in question varied significantly from one currency to another.
The Board of UBS Securities Japan Co. Ltd., (UBSSJ) has authorized UBSSJ to enter a plea to one count of wire fraud relating to the manipulation of certain benchmark interest rates, including Yen LIBOR. The Board of UBS AG has authorized the firm to enter into a Non-Prosecution Agreement (NPA) with DoJ relating to UBS AG and all of its subsidiaries and affiliates, except for UBSSJ.
Today's resolutions stem from industry-wide investigations into the setting of certain benchmark rates across a range of currencies. These investigations have focused on whether there were improper attempts by banks, either acting on their own or with others, to manipulate LIBOR and other benchmark rates at certain times.
UBS has fully cooperated with the authorities in their investigations and significantly enhanced its control framework for its submissions process for LIBOR and other benchmark interest rates. The investigations by other governmental authorities and private litigation referred to in our third quarter 2012 report remain ongoing notwithstanding today's announcements.
UBS CEO Sergio Ermotti said: "During the course of these investigations, we discovered behavior of certain employees that is unacceptable. Their misconduct does not reflect the values of UBS nor the high ethical standards to which we hold every employee. We have cooperated fully with the authorities and taken decisive and appropriate actions to correct the issues and to strengthen our control processes and procedures. We deeply regret this inappropriate and unethical behavior. No amount of profit is more important than the reputation of this firm, and we are committed to doing business with integrity."
UBS Chairman Axel Weber said: "The Board and I have zero tolerance for inappropriate and unethical behavior of any of our staff. We appreciate that the authorities have recognized UBS for the thoroughness of our investigation and our exceptional cooperation. We are pleased that the authorities gave us credit for the important and positive changes we have already made. Our credibility with clients, investors and employees is critical and therefore we have to continue to strengthen the firm's operations, culture and awareness of risk."


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Watch the video
A visit to Caddo Lake is an adventure back in time to an ancient waterway of mysterious intrigue. Settled on the shores of Texas' only natural lake, Spatterdock Guest Houses welcome you to unwind, relax and explore the untamed beauty that is Caddo Lake.
Five different houses to choose from, each of the Spatterdock Guest Houses offers you the opportunity for gracious lake house accommodations with distinct and unique style.
Check Out Our Guests Comments
Billy and Dottie Carter welcome you to Uncertain, Texas and Spatterdock Guest Houses. They want to share with you their "little bit of paradise", they call Caddo Lake. The Carters invite you to visit them at Wildfern, their "dogtrot" home on Taylor Island and enjoy their collection of antique duck decoys, fishing lures, and primitive furniture and other treasures/junk.
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For whatever reason, many a guitar player is satisfied with the idea of "mojo" being responsible for the way certain equipment handles or sounds. Theo Hartman of Hartman Electronics isn''t one of them.
Much like a craps player who is more interested in studying probability than the superstitions involved with what makes a table "hot," Hartman is vocal about his mojo agnosticism. He won''t deny that something unexplainable can exist, but he''d much rather calibrate every known variable involved and explore the nuances of classic components than acknowledge a mysterious x-factor as the main ingredient for a killer tone. You''d expect no less from an architect whose projects include listening environments with top-rate acoustics. Combine that kind of technical precision with the passion of a classically-trained musician and you end up with someone who is uniquely qualified to build guitar pedals for a certain kind of player.
Theo Hartman has tinkered with electronic circuitry for decades but didn''t start making pedals until 2005. In a few short years he has quickly gained a reputation for making equipment that satisfies discerning tastes. We recently had a chance to pick Theo Hartman''s brain about his products and the kind of thinking that leads to a pedal design.
How would you describe your product line?
Every pedal I make is based very closely and faithfully on an out-of-production original from the past 40 or 50 years. My goal is to make the right tools for the job and in each case it's to get that sound. So if you're a producer or a player who needs to achieve a very specific sonic objective my goal is to be able to provide a pedal to do that, no more and no less -- no questions asked. There's no trick to it whatsoever. I think we've all found ways to get tones from things that are other than what we're trying to sound like and that's fine. I'm just trying to make it a shorter walk.
What kind of player digs your stuff?
I think they might be the people who used to buy the UPC symbol groceries in the eighties, the ones with no brand on them with the black letters. They want what's inside. A lot of them are involved in psychedelic rock and to some degree college rock of the eighties (what was then called "alternative rock"). There's been an enormous resurgence of the tube amp in the last decade and a half. An entire generation is discovering why those amps sound the way they do. I think many people who are getting into that are realizing that there are some pedals from the same era that did things that kind of got lost in the shuffle in the heyday of value engineering in the eighties and they're coming back.
You're really into vintage components. Tell me about how that passion came about.
The vintage components I first came across were by accident. I believe in paying your dues and one of the things that attracted me to fuzzes was their incredibly simple circuit. I think it's really easy to get wrapped up in the science and the math of electronics when you're building electrical devices. I really wanted to keep myself grounded in the ear and its role in building these things and the fuzz is a platform that forces you to do that. There are fewer than a dozen parts that go into a fuzz. It's a primitive electrical circuit -- a poor circuit from a strict engineering point of view -- but some of the things that make it deficient in that regard are also what lend its musicality and I was interested in exploring how that happens in a fuzz. Because it's such a simple circuit, the decisions of the builder in selecting the parts that go into it and screening them and matching them up are really a large part of how the pedal ends up sounding.
So for me, that was a very musical, creative act – much more so than the decisions involved with making a Tube Screamer platform and then stamping out 1000 of them. I've heard it said that every fuzz is a snowflake and I think that's as good an analogy as any for describing the amount of variety and level of detail that goes into people's experiences in playing and hearing them. As a builder, that really attracted me because it kept me engaged creatively in every single unit that I was working on. It keeps me on my toes, too. The old parts have electrical characteristics that make them difficult to work with and end up resulting in me rejecting a lot of them but those same sorts of irregularities are also why the good ones sound so musical. It's a double-edged sword. It keeps my head and my ear in the game with every pedal, which is what I love about it.
There are some guitar players who can barely tell the difference between tube types. To be able to tell the difference between a Phillips OC44 and one made by Texas Instruments, we're talking about a certain caliber of clientele, aren't we?
That's true and it brings up an interesting point about who you're building pedals for and why. There is no way around individually screening transistors that go into a Fuzz Face circuit. If you ignore doing so, you do so at your own peril and at the expense of how what you build sounds. But there are more sophisticated electrical circuits that people use or make all the time that don't require that level of involvement from the builder. This gets into the really interesting question of when does something cease to be boutique and why.
I am not a big believer in boutique for boutique's sake. I see lots of amazing designs getting built well on a fairly large scale, and I'm a believer of using technology that is available to do it right and to be able to pass on the value that comes from that scale of manufacturing to customers. In fact, a couple of the designs that I'm working on at the moment will require no individual parts screening from me as a builder once they are launched. I take a hard look at it this way: how do I make my production of the same level of value to people who aren't listening for the difference between an OC44 and an OC71 transistor in their treble booster but want the functionality of these new designs.


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SAMJ: South African Medical Journal
On-line version ISSN 2078-5135
Print version ISSN 0256-9574
SAMJ, S. Afr. med. j. vol.102 n.3 Pretoria Mar. 2012
HPCSA: security and quicker registration remain elusive
The known tally of foreign doctors falsely registered with the Health Professions Council (HPCSA) over the past 11 years now stands at a dozen. How many others have managed to evade the cordon of retrospective checks once the alarm bell has sounded is now an open question - unfairly adding pressure on a cadre already stigmatised for a host of reasons, not the least of which is systemic xenophobia.1 For an organisation whose mission is to 'guide the professions and protect the public' this is not the stuff that confidence is built on, nor does it help address the human resources crisis in the rural areas to which most of these doctors are posted. One cannot argue with new Acting Registrar Dr Kgosi Letlape's determination to stamp out 'insider help' among his administrative clerks and tighten procedures, 'whether it takes 10 years or three months'. Yet the human resources crisis begs a wider view that gets the job done far more quickly while re-engineering procedures to as close to 'fail-safe' as possible. A read of Chris Bateman's story on the latest case2 also raises questions about supervision - the so-called ultimate safety net.
Medical terms in African languages
In southern Africa medicine cannot be taught in indigenous languages (apart from Afrikaans if also classified as indigenous), as there has been neglect of the development of such technical language. Farai Madzimbamuto explores ways in which a technical language can be developed, illustrating his approach with anatomical terms in the ChiShona language.3
Clinical and technical information in most African languages involves inexact terminology and code switching, thus lacking the explanatory power of the English language. African languages are absent in tertiary science education and forums where African scientists could present scientific material in the medium of African languages.
Languages use many methods for acquiring new terms. In ChiShona they have been acquired from English, Nguni, Afrikaans and Portuguese over centuries. Loan translation and semantic extensions are used extensively as a way of using the language's own resources rather than borrowing. The author illustrates the use of word compounding to demonstrate terminology development. Advancing the language can promote similar developments in others, making them more explanatory for the lay public and health professionals.
Cataract surgery improves care of orphans
In a rather nice touch, three academic generations of ophthalmologists collaborate in evaluating the impact of a cataract surgery programme on the care of orphans and vulnerable children in Swaziland.4 They studied patients aged 50 years and older undergoing age-related cataract surgery and who reported having children living in their households. The impact of the AIDS epidemic and effects on families is starkly illustrated. In Zimbabwe approximately 71% of grandparents older than 60 years have responsibilities for children orphaned by HIV/AIDS, and in South Africa each elderly caregiver looks after an estimated average of 4.6 children.
The World Health Organization called for practical and sustainable approaches to improve the capacity of older people to provide care for orphaned dependants. Cataract is the leading cause of blindness in Africa, including Swaziland. The authors show that cataract surgery on elderly visually impaired patients has the potential to impact positively on the care of orphans and vulnerable children. This provides a further good economic reason to increase the capacity to roll out cataract surgery for those in need in Africa.
Childhood poisoning
Poisoning in childhood comprises a significant component of injury-related morbidity and mortality. Balme and colleagues5 compare the trends of causative agents over the past two decades at Red Cross War Memorial Children's Hospital.
Their study reveals similar trends in causative agents over both two decades, which are comparable with trends in other developing nations. The growth in the number of pesticide incidents is alarming, with marked morbidity and mortality demanding advanced resources. Incidents due to household cleaning products have increased over 20 years. Despite the decrease in incidents due to drugs and paraffin, they remain responsible for almost 60% of new presentations. Although the benefits of simple preventive measures such as childresistant containers have been shown, paraffin remains the biggest single cause of poisoning.
Although exposures and poisonings by drugs remain a global concern, most drug subgroups cause limited morbidity. This contrasts with the alarming morbidity and mortality associated with traditional medicine in their study.
The study highlights significant suburban differences that provide the opportunity for targeted educational programmes and application of preventive measures such as child-resistant caps, but most importantly advocate for enhanced socio-economic development.
Nurses risk acquiring blood-borne virus infection
Hepatitis viruses including B (HBV) and C (HCV) are some of the many occupational infectious blood-borne pathogens for which healthcare workers (HCWs) are at risk. Kew and colleagues6 did a follow-up study 10 years after it was shown that 30.6% of nurses in an academic hospital in Johannesburg were positive for anti-HB, indicating resistance to HBV. At the time of the first study recommendations were made for a cost-effective approach to the prevention and management of viral hepatitis. A decade later, at most 52.4% of the nurses are now protected against HBV infection. A high HBV infection rate and low vaccine coverage among HCWs including nurses has also been documented in Kenya and Albania. Nurses therefore remain at high risk of workrelated HBV infection.
1. Bateman C. Vital foreign qualified doctors face xenophobia. S Afr Med J 2011;101:788-792. [ Links ]
2. Bateman C. Bogus neurosurgeon beats system hands down. S Afr Med J 2012;102:115-117. [ Links ]
3. Madzimbamuto FD. Developing anatomical terms in an African language. S Afr Med J 2012;102:132-135. [ Links ]
4. Pons J, Mapham W, Newsome B, Myer I, Anderson R, Courtright P, Cook C. The potential impact of a cataract surgery programme on the care of orphans and vulnerable children in Swaziland. S Afr Med J 2012;102:140-141. [ Links ]
5. Balme K, Roberts JC, Glasstone M, Curling L, Mann MD. The changing trends of childhood poisoning at a tertiary children's hospital in South Africa. S Afr Med J 2012;102:143-146. [ Links ]
6. Mosendane T, Kew MC, Osih R, Mahomed A. Nurses at risk for occupationally acquired blood-borne virus infection at a South African academic hospital. S Afr Med J 2012;102:153-156. [ Links ]


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Sixers-Devils boss not worried about poker deal
NEWARK, N.J. (AP) — The chief executive of the NHL's New Jersey Devils and NBA's Philadelphia 76ers doesn't believe the teams will be cast in a bad light by agreeing to a multiyear sponsorship deal with one of the world's leading online poker companies.
Scott O'Neil, who runs the teams and the Prudential Center for groups led by leverage buyout specialist Josh Harris, and Norbert Teufelberger, the chief executive of bwin.party digital entertainment that operates partypoker, announced the historic deal Thursday.
It's the first between major U.S.-based professional teams and an online gambling company, but there were immediate questions about the relationship between sports and online gambling, which isn't seen positively in all circles.
O'Neil called it new territory, and hopes the reward outweighs the risk. The former NBA executive noted that his old employer held its All-Star game in Las Vegas in 2007 and its WNBA All-Star game at Mohgan Sun Casino in Connecticut in July.
"This doesn't seem like we're breaking any taboos," O'Neil said. 'I think for us the most important thing is being with a partner that can really engage our fans in a smart way and someone who understands for those of our fans who do play poker and those that are inclined for gaming whether they come to concerts here or a Sixers' game or a Devils' game they will be treated like a royal flush, if you will."
Partypoker ceased operations in the United States seven year ago after laws were changed, Teufelberger said, adding it has been looking to return for a while.
It has operated in Europe and has partnerships with some of the world's top soccer clubs — Manchester United in England, Real Madrid in Spain and Bayern Munich Germany.
Teufelberger realizes coming back to the United States is a new game.
"We have learned over the many years, with Real Madrid and Manchester and Bayern, and especially here in this country where it's such a controversial topic, that we're not just selling toothpaste," Teufelberger said. "We're selling a product that can be viewed as very problematic. It has to be engaging, it has to be entertaining, but it shouldn't be addictive."
New Jersey authorized Internet gambling last year to give a boost to Atlantic City's struggling casino industry, which has been beset by increasing competition for the past seven years. It began with a five-day trial period on Nov. 21 and launched publicly on Nov. 25.
As of Monday, 148,487 accounts had been created, though the state's Gaming Enforcement Division notes that individuals often create separate accounts on more than one site.
O'Neil said some 60 million people play poker in the United States.
"I hope they get to New Jersey and come to the Prudential Center and I hope they all go on partypoker.com," he said.
Neither O'Neil not Teufulberger would disclose the length of the partnership nor the amount involved in the agreement.
Teufulberger could not estimate how many money partypoker hoped to earn through the agreement, but added the company hoped to secure 20 percent of the online business in New Jersey.
Included in the partnership is the integration of partypoker into the Devils and 76ers websites and social media channels, and mobile applications; tickets and hospitality; in-arena signage, including dasherboards, on-ice and on-court; and rights to broadcast television and radio advertisements during Devils and Sixers games.
There will be booths at the Prudential Center to explain how to play online.
New Jersey is the third state in the nation to offer Internet gambling, after Nevada and Delaware.
The partypoker partnership will be immediately visible Saturday at the Prudential Center, when the Devils play, and the Wells Fargo Center, the home of the Sixers. Fans at the Prudential Center could play online after downloading an app on their cell phone.
"All the other states are watching how we do this," Teufelberger said. 'We're really under the microscope here."
O'Neil and Teufelberger said the partners have not explored what would happen if sports gambling were legalized in New Jersey.
"It'd be very difficult with the leagues at this point in time," O'Neil said, noting the NBA had to make some adjustments to its laws to allow the deal.
And if it did happen?
"The leagues would have a tough time with it. That's a moment in time," O'Neil said. "I'm fascinated and curious how this plays out over time, because we all know what's coming. We just don't know when how what or why. I wouldn't want to speculate."


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Monitor acquires Roksan in stereo equipment tie-up
High-end stereo equipment manufacturer Roksan Audio has been acquired by leading speaker specialist Monitor Audio in a deal advised by BCMS.
Founded in 1985, London-based Roksan is renowned among music aficionados for producing prestige turntables, CD players and amplifiers, with product ranges including Kandy, Caspian and Oxygene.
Essex-headquartered Monitor Audio – which sells into 100 countries worldwide – has built a market leading position in hi-fi and home cinema speakers, along with streaming products.
Monitor Audio Managing Director Andrew Flatt said: "Monitor and Roksan are both UK companies committed to superior audio performance and premium quality. We believe we could triple Roksan's sales pretty quickly, so we're excited about the possibilities this acquisition offers."
Roksan Audio Managing Director Tufan Hashemi added: "We have been striving to develop a range of speakers for a while, and Monitor has been keen to launch a range of turntables and amplifiers, so the combination of two great niche brands will serve both companies well."
The acquisition includes all employees, brand ownership and equipment, along with manufacturing facilities in northwest London. Terms and the value of the acquisition have not been disclosed.
BCMS acted as lead financial advisor to Roksan, and Deal Leader Mark Lucas commented: "Both parties got on well from the outset, which aided us in completing this transaction very quickly. The combination of Roksan and Monitor has created a powerful new force in the UK stereo market, and we wish everyone a successful future."
M&A Deal: PSAV acquires Concise
Shepard Announces Acquisition of Production Associates, Accelerating the Growth of their Audio Visual Division
Webinar: Timing is everything - how to prepare your business for a successful sale


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This article is from the archive of our partner .
In the latest installment of the hot sauce apocalypse saga, officials in California have declared the production of Sriracha hot chili sauce a public nuisance and are threatening to shut it down forever. The announcement was a long time coming — back in October, residents of Irwindale, the California town where sriracha is produced. were complaining of irritated eyes, headaches and sore throats, due to emissions from the factory. In November, the city council ordered the Huy Fong Foods plant, the company that makes the iconic sauce, to shut down.
After a unanimous vote on Wednesday, Irwindale's city council have issued an ultimatum to Huy Fong: reduce the wafting smell of the beloved spicy condiment, or someone else will do it, reports Rory Carroll at the Guardian. Huy Fong's attorney, John Tate told the hearing that lingering smell will be under control by June and the company will have an "action plan" ready in 10 days.
Getting rid of the smell is especially time-sensitive: chili grinding season, the time of year that creates the strongest odor, starts in August, reports Sarah Favot at the Pasadena Star-News. Right now there is no immediate risk of shutdown, but the company is clearly feeling the heat, so to speak. Time is running out, but there's no "srirachapocalypse" just yet.
This article is from the archive of our partner The Wire.
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text:
I've searched the forum, but I haven't been able to spot this topic.
Towards the end, personally my submission frequency increased, while my focus on the process shifted towards the goal.
I would like to deconstruct my process, but I've lost the original code to a corrupted harddrive.
But on my user info page, under "contest submissions" I can see all my submissions listed, I would be grateful to be able to download them all. ( http://aichallenge.org/profile_submissi ... 617&page=1 )
TL;DR Allow re-download of submission for logged in user on aichallenge.org


text:
Story highlights
- Leave nature as you found it, the National Park Service says
- But a little girl named Evie takes home two sticks from Yosemite National Park
- She feels guilt and returns them in a letter of apology
- Park rangers keep her letter and the two sticks posted on a wall for a year
It may as well be the 11th Commandment: Leave nature as you found it, the National Park Service says.
So imagine the horror of a little girl named Eve -- no, Evie, to be exact -- when she violated the Eden that is Yosemite National Park.
Her sin: She took home two sticks.
Park Ranger Matt Holly learned of this transgression during a routine day opening hundreds of letters from visitors awed by Yosemite.
The handwritten note from Evie read:
"Dear Park Rangers,
"I am a Yosemite Junior Ranger. I went to Yosemite recently and accidentally brought home two sticks. I know I'm not supposed to take things from the park, so I am sending them back. Please put them in nature.
"Thank you,
Touched by her innocence, Holly taped the two sticks to her letter and temporarily hung it over his desk.
It's been hanging there for almost a year, he said.
"We all loved it," the public information officer told CNN this week. "It was so moving to see how small the sticks were."
He contacted the family, who are park regulars, and told them of how Evie's note moved all the park rangers.
They are now preparing to reunite the sticks with their home.
"I think we are about ready to return them to where they belong, back in nature," Holly said. "The family comes here often, they know a lot about the park and she kind of knows where she wants them."
Evie's letter is now being considered for display in Yosemite's visitor center or elsewhere, Holly said.
The U.S. Department of Interior may already have its caption. On its Twitter account this week, the agency commented about the letter of apology from the junior park ranger, a title given to youths between ages 7 and 13 who complete a program while visiting a national park. It said:
"Cutest. Story. Ever."


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A universally unique identifier (UUID) is assigned to a zone when it is installed. The UUID can be obtained by using zoneadm with the list subcommand and the -p option. The UUID is the fifth field of the display.
View the UUIDs for zones that have been installed.
global# zoneadm list -p
You will see a display similar to the following:
0:global:running:/: 6:my-zone:running:/export/home/my-zone:61901255-35cf-40d6-d501-f37dc84eb504
global# zoneadm -z my-zone -u 61901255-35cf-40d6-d501-f37dc84eb504 list -v
If both -u uuid-match and -z zonename are present, the match is done based on the UUID first. If a zone with the specified UUID is found, that zone is used, and the -z parameter is ignored. If no zone with the specified UUID is found, then the system searches by the zone name.
Zones can be uninstalled and reinstalled under the same name with different contents. Zones can also be renamed without the contents being changed. For these reasons, the UUID is a more reliable handle than the zone name.
For more information, see zoneadm(1M) and libuuid(3LIB).


text:
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The Active 12 is our 2nd generation sports GPS device. With a HighRes screen for even more clarity when viewing maps of all scales and low energy bluetooth to allow for wireless route sharing between devices. All within our robust weather resistant casing.
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Read more on the Active 12.
Read more on great Active 20 Trade-In offers.
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August 28, 1928 - September 26, 2013
Newburgh, NY
Agustin Gomez, 85 of Newburgh, entered into rest on Thursday, September 26, 2013.
Son of the late Cirpriano and Carmen Gomez, he was born August 28, 1928 in Mendoza, Argentina.
He is survived by his wife, Crucita Gomez, at home; his children: Maria Rosa Gomez and Agustin Gomez; step children: Miguel, Gerson, Jose Luis and Angel Manuel Cruz; 12 grandchildren: Adri, Agustina, Lemec, Yanira, Jason, Gerson Jr., Maria, Joel, Keisha, Jafet, Ajalet and Erica; and 11 great-grandchildren: Valerie, Crystal, Ayanah, Sarah, Ariana, Cyrus, Naileene, Derrick, Damani, Naiyla and Leilani.
Visitation will be held from 4 to 8 p.m. on Sunday, September 29th at First Spanish Assembly of God Church, 25 William St., Newburgh, where Agustin was a parishioner.
To send a personal condolence or further information, please visit www.Brooksfh.com or call 845-561-8300.


text:
Bold River City — Womens Richmond T-Shirt by Amir Dennis
An original design by Amir Dennis in Richmond, Virginia. A bold choice.
Slim fitting with a longer length. Made with premium quality fabric and construction. Extremely soft, wears well and holds its shape and color over time. Can be dressed up or dressed down. SEE BELOW — SIZING RUNS EXTREMELY SMALL!
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- Pre-washed to minimize shrinkage; Side-seams for fit and stability


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What exactly is AWS?
AWS, or Amazon Web Services, is one of the most successful yet littlest known components of Amazon. Yes, the same Amazon you likely buy your toilet paper from also operates one of the largest cloud platforms on the web.
As described by Amazon, "Amazon Web Services (AWS) is a secure cloud services platform, offering computing power, database storage, content delivery and other functionality to help businesses scale and grow."
AWS supports a growing number of customers, ranging from small-medium businesses to enterprise firms such as Kellogg's, Conde Nast, Airbnb, Lyft, Slack, Thrive Market, and so many more. A growing user base also means that more and more companies are looking to hire professionals with extensive knowledge around setting up, managing, and securing AWS. It's not just Amazon hiring for AWS professionals — it's thousands of companies around the world.
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New Search
- NGC Cert #
- 4629125-050
- NGC Description
- c.5th Century BC ACHAEMENID EMPIRE AV Daric
- NGC Grade
- MS Strike: 5/5 Surface: 3/5
- Pedigree
- spear. rv incuse punch. obv hero-king w/bow &
- Comment
- flan flaw
If the information displayed above is incorrect or does not match the coin you are verifying, or if you believe that you have a counterfeit or tampered NGC holder, please contact firstname.lastname@example.com. To learn more about counterfeit or tampered NGC holders, click here.
*Population in Higher Grades calculation
Population in Higher Grades reflects the number of coins in the NGC Census population report in higher numeric grades and strike characters. For example, the Population in Higher Grades for a coin graded MS 67 BN would reflect the population for MS 67 RB and MS 67 RD (since these are higher strike characters) as well as all the population for higher numeric grades. Likewise, if a coin is graded MS 70 PL, the Population in the Higher Grades would reflect the population for MS 70 DPL (is any).
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text:
Learn how to design, execute, interpret, and report on simple psychology experiments! David W. Martin blends humor, clear instruction, and solid scholarship to make this concise text a perfect introduction to research methods in psychology. DOING PSYCHOLOGY EXPERIMENTS guides you through the experimentation process in a step-by-step manner. Martin emphasizes the decision-making aspects of research, as well as the logic behind research procedures. He also devotes two separate chapters to many of the ethical questions that confront new experimenters ? giving you a complete introduction to the psychology laboratory.Martin, David W. is the author of 'Doing Psychology Experiments ', published 2007 under ISBN 9780495115779 and ISBN 0495115770.[read more]
{{post.questionOneAnswer|unescape}} {{post.questionTwoAnswer|unescape}}[read more]
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Have interest and click the website to consult:
In daily life, some people can't do without wheelchair. For this special group, free travel becomes the deepest desire. However, their shared desire may come true since Airwheel H3 smart wheelchair comes into being. It is never an ordinary wheelchair and its whole body sends out a strong sense of wisdom. The following will unveil its true self in detail.
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text:
The E-direct offering of "components to complement a measuring point" contains display units, process meters, field indicators, process transmitters, surge arresters, barriers and much more. They cover a wide range of applications throughout various industries.
Analog measured values are indicated, evaluated and calculated by process transmitters. With the integrated loop power supply two-wire sensors can be powered. The universal inputs enable the connection of current, voltage, RTDs and TCs. Limit values can be monitored and relays can be switched. Process signals via analog outputs can be forwarded. Plant availability is very important as even short failures in production may cause high losses in sales. Therefore an individual protection of the devices e.g. surge protection as well as a high availability of plant parts needs to be ensured.


text:
"This You Chose"
This you chose, you know, the lethal wound, external fire,
Internal final cut the cleanest; the choice was never mine.
This you chose; your arms, your scent defined
The borders, walls, the floors, the exposure. Your desires
Say nothing past the yesterdays of pre-dawn, and glad
I was to rest the while, and glad you are that I am gone.
But nothing's rendered in the late night's song,
The me in you, and yes! You know the sad
Result: that moon's pain can not know a sequel.
The senses, these you know , with no contempt,
But radiant resignation in the hours of heat and pure idolatry. Spent,
The sentence stands within this world. These final sentiments rule;
The veil, the truths we've always known; the hourglass, the idols of our nights,
Its sands, a closing hush of breath at daybreak when all our meteors take flight.


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We are in the business of providing peace of mind and your confidence is our number one priority. We follow a Code of Ethics, and a very disciplined policy with respect to your privacy, as well as how we collect, maintain and store your personal information. We also have the highest degree of website security around our online access. These policies are written in plain language and outline our commitment, as well as certain user responsibilities and caveats about accuracy etc. Please take a few moments to familiarize yourself with these policies.


text:
Categories » Geography »
- 0 comments
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- 31771 visits
This report contains the list of all the municipalities in Extremadura ordered by their area. The information comes from the National Geographic Institute (NGI). In Ancient Rome, a municipium (Latin word which gave rise to the Spanish word "municipio") was a free city governed by its own rules. That has little to do with current city halls, however. In fact, municipalities in Spain were mapped out in the 19th and 20th centuries around the most representative population nuclei of each territory. Even so, as can be confirmed in this report, the surface areas of different ones vary greatly.
- Author: ivy (Updated Jul 5, 2011)
- Sources: Classora Rankings Group National Geographic Institute
Did you know you can display the rankings in different ways?


text:
Thin Crash
Sizes: 14" 16" 17" 18" 19"
Weight: thin
Volume: low to medium loud
Stick Sound: velvety, washy
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Sustain: medium
Bell Character: integrated
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Home > Products > Cymbals > PST 7 > Crashes > Thin Crash | Crash | Heavy Crash |


text: heart pin xl January 22, 2020 by Editor Editor Jo Malin created this blog for modern couples who yearns for the extraordinary. Based on her sheer love of transparent planning advice, artful styling and contemporary bridal looks, she writes for the freedom of getting married the way you want. When she is not editing the blog, you can find her sketching and sewing for the new label Sheer Bride, vintage shopping, building a ceramic sculpture or walking on the beach.


text:
The euro zone's debt crisis is just the center of an "adjustment" which is affecting all advanced economies, former European Central Bank (ECB) President Jean-Claude Trichet told CNBC.
"The Europeans have a special responsibility because we are the epicenter of the worst crisis since World War II. And that, of course, calls for highly responsible decisions," he said.
All the advanced economies are undergoing their first major adjustment since the Second World War, according to Trichet.
"When you look with historical credit at what has happened since 2007, it was the start of the adjustment of the advanced economy. We have to understand-- it's our turn. We cannot ask the rest of the world to finance us eternally if we spend more than we earn. As simple as that," he said.
"We paid quite a high price for a dominant vision, which was too much benign neglect before the start of the crisis."
He also highlighted several "naïve beliefs" from policymakers in the pre-crisis days, including the belief that the developed world's financial and economic systems were "stable and resilient" because they absorbed the dotcom bubble bursting in the early years of the twenty-first century.
Central banks across the board in the advanced economies – including the Bank of Japan and the U.S. Federal Reserve, are engaged in "non-standard measures" to protect their economies, he pointed out.
The Fed announced its third round of quantitative easing on Thursday, which was followed by a rally in markets around the world, while the ECB's widely-anticipated bond-buying program, dubbed "Outright Monetary Transactions", which will buy up bonds of struggling countries if they threaten to rise to levels which make borrowing costs unsustainable, was announced last week. (Read More: Will Post-Fed Market Rally Last?)
"What has been done in the case of Europe, is commensurate to the gravity of the situation. But it has to be checked," Trichet said.
Governments now have to use the time provided by these measures to work hard to restore their economies to health, according to Trichet, who warned that there "is very hard work to do in all advanced economies.
Trichet was confident that history would judge him well for his eight-year stewardship of the ECB, which finished with his handover to Mario Draghi last year.
He also called for an end of the belief that some financial institutions are "too big to fail," which led to many of the banking bailouts that increased governments' debt burdens during the credit crisis.
Quick delivery by governments and conditions being placed on the new bond-buying program are the key factors for the euro zone right now, Trichet argued.
The man who steered the euro zone through the early years of the crisis, called for "speedy and expeditious delivery" by governments.
He said of the bond-buying program introduced by his successor: "It has to meet the requirements and conditions, including to be commensurate to the destruction of pocket we have to cope with. It has to be accompanied with appropriate messages for the private and public sector."
"I think it is extremely important not only for the euro but the rest of the world," Trichet said.
"It depends on the governments individually to adjust and collectively through the ESM (European Stability Mechanism) to deliver. In the past, they did not always rapidly and actively. Governments are not necessarily delivering what they promised." (Read More: Will ESM Be Big Enough?)
The French economist also argued that it was not just the struggling peripheral economies which need to deliver, but also the stronger economies which have to prop them up. Germany , the euro zone's biggest economy, was the only member of the ECB to vote against the plan for OMTs last week.
"We have those who have problems, and they are clearly identified. But there are those who are part of the college who have to understand that their prosperity and stability is associated with the stability of the whole," Trichet said.
He warned that Greece exiting the euro would be the "worst possible decision for the Greeks themselves… and also of the rest of Europe and the entire world." (Read More: Greece Denies Report of Third Bailout)
"Of course history is not written and it depends on the decision of the various countries concerned," he added.
Reported by Michelle Caruso-Cabrera, CNBC Chief International Correspondent. Written by Catherine Boyle, CNBC. Twitter: @catboyle01.


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Pilot Study on the Effect of Adding Raltegravir +/- a Second Drug on HIV Levels in the Gut (PLUS)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00884793
Recruitment Status : Completed
First Posted : April 21, 2009
Results First Posted : July 23, 2012
Last Update Posted : July 23, 2012
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections
|Drug: raltegravir Drug: Study NNRTI Drug: Study PI
|Not Applicable
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|8 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Official Title:
|A Prospective Longitudinal Pilot Study to Measure the Effect of Intensification With Raltegravir +/- a Protease Inhibitor (PI) or Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) on HIV-1 Levels in the Gut
|Study Start Date :
|September 2008
|Actual Primary Completion Date :
|December 2009
|Actual Study Completion Date :
|December 2010
Experimental: intensification with raltegravir +/- NNRTI or PI
Intensification with raltegravir 400mg PO BID +/- a study PI or NNRTI
Drug: raltegravir
The baseline ART regimen will be intensified with raltegravir 400mg orally (PO) twice daily (BID) (all participants) +/- a study NNRTI or protease inhibitor (PI) (at the option of the participant and the study clinical team).
Other Name: Isentress
Drug: Study NNRTI
Subjects who are not already on an NNRTI and who are suitable candidates will have the option of adding a study NNRTI (either efavirenz or etravirine).
Other Names:
Drug: Study PI
Subjects who are not on a PI and who are suitable candidates will have the option of adding a study PI. PIs used as study drugs will include atazanavir (+/- ritonavir), fosamprenavir (+/-ritonavir), lopinavir/ritonavir, and darunavir/ritonavir.
Other Names:
- Number of Subjects Who Had a Decrease in HIV RNA Per Million CD4+ T Cells in the Ileum [ Time Frame: 12 weeks ]Number of subjects who had a decrease from week 0 to week 12 in unspliced cell-associated HIV RNA per million CD4+ T cells in the ileum
- Number of Subjects Who Experienced an Increase in CD4+ T Cells (as a % of All Cells) in the Ileum. [ Time Frame: 12 weeks ]Number of subjects who experienced an increase in CD4+ T cells (as a % of all cells) in the ileum (by flow cytometry) from week 0 to week 12.
- Number of Subjects Who Experienced an Increase in CD4% in the Ileum. [ Time Frame: 12 weeks ]Number of subjects who experienced an increase from week 0 to week 12 in CD4+ T cells (as a % of T cells, by flow cytometry) in the ileum
- Average Change in "Activated" (CD38+HLADR+) CD8+ T Cells in the Ileum [ Time Frame: 12 weeks ]Average of changes(week 0-week 12) in the % of CD8+ T cells that are CD38+HLA-DR+, by flow cytometry
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age 18 to 65 years
- Infection with HIV-1, as documented by a licensed ELISA and confirmed by a Western blot or HIV-1 RNA at any time prior to study entry
- On ART for at least 12 months prior to study entry with a regimen that includes at least two NRTIs and either an NNRTI or PI
- No change in ART for at least 3 months prior to study entry.
- CD4+ T cell count of 200 or greater within 30 days prior to study entry.
- HIV-1 RNA level consistently below the limit of detection of commercial ultrasensitive assays (<50 copies/mL) for at least 6 months before study entry.
- Women of reproductive potential (those who have not undergone surgical sterilization via hysterectomy, bilateral oophorectomy, or tubal ligation and who have had menses in the preceding 24 months) must have a negative urine or serum pregnancy test within 48 hours prior to study entry.
- All subjects must agree not to participate in the process of conception (such as active attempts to impregnate or become pregnant, sperm or egg donation, in vitro fertilization) while receiving study drugs and for 6 weeks after stopping study drugs. If participating in sexual activity that could lead to pregnancy, the subject and/or partner should use at least two reliable methods of contraception, including oral contraceptive pills, an intrauterine device (IUD), condoms, and a diaphragm or cervical cap with spermicide.
- Ability and willingness to provide informed consent.
Exclusion Criteria:
Any condition that, in the opinion of the GI specialist, would either be a contraindication to endoscopy or would increase the risk from sedation, endoscopy, or mucosal biopsies. These conditions may include, but are not limited to:
- Significant complication (such as perforation) from prior endoscopy
- Known bleeding diathesis
- Platelet count < 100,000 per microliter
- Current use of antiplatelet agents (aspirin, other NSAIDS, clopidogrel (Plavix), other antiplatelet agents) or anticoagulants (heparin, low molecular weight heparin, warfarin, lepirudin, or other anticoagulants) and inability to temporarily hold such medications for endoscopy.
- Active angina, unstable angina, or MI within 2 months prior to study entry
- Decompensated CHF
- Respiratory insufficiency with FEV1 < 1L, resting hemoglobin saturation of <92%, or need for oxygen supplementation
- OSA requiring CPAP
- Ongoing substance abuse
- Peripheral glucose > 350 mg/dL
- Prior use of raltegravir
- Any condition that, in the opinion of the infectious disease (ID) specialist, would be a contraindication to raltegravir. These conditions may include, but are not limited to: unstable clinical condition (such as recent hospitalization, cancer with need for chemotherapy or radiation); severe hepatic insufficiency; need for contraindicated medicines; breastfeeding; or high risk for myopathy or rhabdomyolysis.
- Calculated creatinine clearance (CrCl) < 50 mL/min, as estimated by the Cockcroft-Gault equation
- AST (SGOT), ALT (SGPT), alkaline phosphatase, or bilirubin > 3x the upper limit of normal (ULN).
- LDL > 200 mg/dL or TG > 400 mg/dL in fasting lipids, as measured within three months prior to screening or at the time of screening
- Plan to change the background ART within 16 weeks after study entry
- Receipt of any HIV vaccine
- Receipt of a non-HIV vaccine within 30 days prior to study entry
- An opportunistic infection within 60 days prior to study entry
- Use of significant immunosuppressive medications (such as systemic corticosteroids, tacrolimus, sirolimus, mycophenolate, azathioprine, interferon, and cancer chemotherapy) within 60 days prior to study entry.
- Active drug or alcohol abuse that, in the opinion of the investigator, would interfere with adherence to the requirements of the study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00884793
|United States, California
|San Francisco General Hospital
|San Francisco, California, United States, 94110
|San Francisco VA Medical Center (SFVAMC)
|San Francisco, California, United States, 94121
|Principal Investigator:
|Diane Havlir, MD
|San Francisco General Hospital (SFGH) and University of California San Francisco (UCSF)
|Principal Investigator:
|Joseph K Wong, MD
|San Francisco VA Medical Center (SFVAMC) and University of California, San Francisco (UCSF)
|Principal Investigator:
|Steven Yukl, MD
|SFVMAC and UCSF
|Responsible Party:
|University of California, San Francisco
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|April 21, 2009 Key Record Dates
|Results First Posted:
|July 23, 2012
|Last Update Posted:
|July 23, 2012
|Last Verified:
|June 2012
residual replication
gut-associated lymphoid tissue
treatment experienced
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Atazanavir Sulfate
Raltegravir Potassium
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors


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East Yorkshire Delivery Company
Removals (Hull & Beverley), National Removals, Deliveries & Self Storage
East Yorkshire Delivery Company is a family run business based in the historic Market Town of Beverley, East Yorkshire. East Yorkshire Delivery Company is a well established business with in excess 14 years of experience in the removal industry and also retail deliveries industry.
We have a massive regular customer base within the removal and delivery business which takes us through the whole of the UK and Ireland.
We like to think of ourselves as the company with the whole package, removals with well trained staff who have been with the company from the beginning who understand the pressures and stress of our customers on moving into there new homes/offices.
East Yorkshire Delivery Company work alongside Armadillo storage, Store More Self Storage and Poppy Storage for those who may need to move into storage. Whether it be to complete the sale of their property, to those who may be doing restoration work to their own homes or those who may be relocating with there career changes. Whatever the reason we are here to cover all aspects of your moves weather it be residential or commercial.
East Yorkshire Delivery Company offer packing services with packing materials national and European, we offer dismantle and rebuilding services of your furniture, we can cater for everybody's individual needs.
With the delivery side of the business, we look after a large range of exclusive retail furniture stores within the whole of the UK, from Beverley to Knightsbridge and London to Ireland and many more.
Within Beverley, we deliver for stores such as Multiyork, Laura Ashley, Ladygate Interiors, Carol Bird interiors and Alexandra Ellis.
Within the City of Hull we deliver for Beds on Legs, Argos, Shakers Furniture Store, Magnet Kitchens, Maiden Head Aquatics and the bespoke kitchen company Hepworth & Wood.
We are local to the East Yorkshire area, however we work nationwide throughout the UK, Ireland and Europe. We are based in Beverley, just outside of Hull, where we have established many local contracts and regular customers who use us repeatedly.
Here are some of the services East Yorkshire Delivery Company offer:
- Removals – Domestic & Commercial
- Deliveries – from Individual Items of furniture to full kitchens & much more
- Packaging Materials
- Packing Services
- Storage Facilities#
- Disposal Services – offered alongside Removals & Deliveries
- Building & Dismantling Garden & Household Furniture
- Office Removals, Relocation & Re-Organisation


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Office Suite New York City
December 10, 2015
Our local experts are ready to serve you. Visit our website >>> Commercial Real Estate . . . . . . Princeton, Palm Hilo, St. Ketchikan, Paducah, Chibougamau, MI PA Kodiak, TX MS Haven, CA CT Sarnia, IL CA City, Palm KS TX QC NJ Albany, BC Island BC VA locale HI Watertown, GA Jacksonville, IA … More Office Suite New York City


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Aart Oxenaar
March 31
Stefan Behnisch and Thomas Auer
April 5
Susannah C. Drake
April 20
Craig Dykers
April 26
David Hacin
May 4
March 31, 2011
Abstract: Educating Architects for a Transforming City explored the concurrent education model and the ways in which it exemplifies the notion of a 'Porous Academy' by facilitating constant exchange between School and City. Aart discussed the century-old relationship between the Academy of Architecture and the City of Amsterdam, as well as the importance of the concurrent education model in building and supporting the network that has made successful collaboration possible. He shared insight on how this exchange is evidence of the ability and necessity of architecture schools to remain open to the changing demands of society, while simultaneously maintaining the essence of the craft of architecture within a variety of contexts.
Dr. Aart Oxenaar, Director of the Academy of Architecture, Amsterdam School of the Arts, studied art history and archeology at the University of Amsterdam. With the support of the Netherlands Organization for Scientific Research, he has conducted research into the work of P.J.H. Cuypers. He has worked for the Netherlands Architecture Institute in Rotterdam as a writer and exhibition maker, and was the Founding Coordinator of the Centre for Architecture and Urbanism in Tilburg. Since 1998 he has been Director of the Amsterdam Academy of Architecture. He is active as an advisor in the field of architecture and planning, as a member of the IJburg Quality Team and chairperson of the Committee for Building Quality and Monuments in Amsterdam and serves on the Advisory Board for Spatial Quality in Haarlem. In addition to his work as an architectural historian, with a focus on the nineteenth century, he has published on contemporary architecture in the Netherlands. In 2010 he obtained his Ph.D. from the University of Amsterdam with an extensive publication on the architect Pierre Cuypers, celebrated designer of the Central Station and Rijksmuseum in Amsterdam, entitled P.J.H. Cuypers en het gotisch rationalisme (NAi Publishers, Rotterdam).


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Around Town
Get started with College Greenlight to compare the University of St Francis weather with your hometown!Create an account now!
There are always fun things to do around campus, and they do give you a free gym membership at a local park district (ice rink and pool!!). Many student organizations have things going on almost everyday of the semester.Read More
Tons of activities and clubs on campus to join!Read More
At the University there are many events always happening. Clubs and organizations are very involved on campus with creating movie nights, service events, talent shows, fashion shows, free bowling, sport tournaments, etc. There is a wide range of different activites to do on campus so students don't ever have to feel like there is nothing to do. Additionally, the Joliet Mall, Barnes and Noble, and two movie theaters are close to campus that students can also enjoy.Read More
There is always some activity going on on campus. Tons of posters and flyers are hung throughout the campus with various meetings and opportunities. Living on campus puts those students at an advantage of knowing what is going on on campus. Clubs are great for passing time. There are events clubs set up outside campus and hold on campus as well. Students can take advantage of the rec center and the free gym membership at Inwood. On weekends the university holds movie nights which is all free. There's never a boring day on campus, students just need to look and keep an open mind.Read More
Clubs and organizations. There are an obscene number of clubs to join, with many being VERY active and having a lot to do. The trick to staying busy here really is to join a club and find your niche, get involved and be recognized.Read More
you can do a lot of things around the school. Chicago is always a busy place. you can go to concerts around or drive to down town Chicago and enjoy a nice day at the beach during the summer or go shopping.Read More
Game room!Read More
Meeting and hanging with friends is always a plus. Many activities are open like bowling night or movie nights. There are tons of activities open to everyone and down the street is a theater with old releases for just a dollar, always a fun and cheap thing to do once a week.Read More
Joliet area offers alot of activities. There are minor league baseball teams, shopping centers, plenty of outdoor activity and Chicago is just a 45 train ride away.Read More


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The week in review
Most epochal: The 10th anniversary of September 11.
Most torrential: A five o'clock thunderstorm September 12 brings hail, a tree on top of a car on JPA, and a stalled car on flooded Old Ivy Road.
Wettest: McCormick Observatory records more than five inches of rain between 9pm September 5 and 5:30pm September 7.
Biggest loss of a community leader: Mary Ann Elwood, first female president of the Charlottesvile Regional Chamber of Commerce, first female chair of the Charlottesville Democratic Committtee, and co-founder of Book Buddies in city schools, dies September 12 at age 78. She received the Paul Goodloe McIntire Citizenship Award in 1998.
Saddest loss: Elizabeth Hewlett Hahn, 49, who anchored the NBC29 evening news programs about 20 years ago and went on to various Richmond careers in the fields of advertising, teaching, and creative writing, dies August 31 after a lengthy illness.
Highest profile arrest: Former mayor Blake Caravati, 60, is charged with assault of a family member September 9.
Wildest wings: A 26-year-old man is shot around 1am September 12 at Wild Wings Café on West Main, and is discovered walking up the street with a bullet lodged in his neck. The victim is in stable condition, and no arrests have been made at press time.
Biggest disparity: William Thompson gets three years in prison August 30 for driving drunk and killing newlywed winemaker Daniel Neumeister. The next day in federal court, Rodney Wayne Barnes gets 22 years for selling cocaine and heroin across state lines.
More varying sentences: Richard Allen Smith Jr., 25, will serve just four years for throttling and bludgeoning to death his friend, Pierre-Louis Rigaut, 23, in July 2010 at Graves Mountain Lodge. However, Demonte Burgess, 20, picks up 10 years for attempted malicious wounding and three other firearms charges for an incident at Wilton Farms on top of 29-year sentence he got in July for the unrelated shooting death of Miguel Lugo Salazar in January 2010, the DP reports.
Biggest dog-shooting sentence: Previous felon Brian Tichner, half of the duo originally charged in January with fatally shooting "Mattie," an Earlysville family dog, gets a three-year sentence, according to the Newsplex. The alleged triggerman Justin Tyler Riggs, pled to a two-year sentence last month.
Biggest brother: Charlottesvile plans to start busting non-helmet wearing, bike-riding kids 14 and younger, who face a $25 fine that can be dismissed for first timers who can prove they own a helmet.
Biggest grant: Nonprofit Charlottesville Tomorrow hires a community engagement coordinator named Jennifer Marley with a $102K grant from the John S. and James L. Knight Foundation and the Charlottesville Area Community Foundation. The expanding, public-meeting-covering organization (and unofficial cheerleader for the dam plan) partners with the Daily Progress, whose employees recently were asked to take another 15 unpaid furlough days before the end of the year.
Uncoolest county: Albemarle supes vote 4-2 September 7 to ditch the county's membership in the Cool Counties initiative, a voluntary nationwide plan to reduce energy usage and carbon emissions.
Latest setback for former High's Ice Cream suspect: The $200 million lawsuit against the city of Staunton filed by William W. "Gus" Thomas Jr., the Spottswood man originally charged in the notorious double slayings, is thrown out of federal court, the News Leader reports. Thomas was acquitted of one death in 1968, but maintains that he remained a conspired-against suspect until 2008, when Sharron Diane Crawford Smith, 60, confessed on her deathbed.
Latest threat to children: SpongeBob SquarePants, according to a recent study that shows four-year-olds who watched the fast-paced cartoon show performed measurably worse on mental function tests than those who watched slower-paced Caillou or those who drew pictures. UVA psychology prof Angeline LIllard, the study's lead author, says SpongeBob shouldn't be singled out, and that other fast-paced shows can affect learning. Nickelodeon responds that SpongeBob is aimed at 6-to-11 year olds, not four year olds, according to the AP.


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At just 23 years old, lightweight contender Chris Horodecki (17-3 MMA, 0-0 BFC) already boasts stints in the WEC and IFL. Now, it's on to Bellator Fighting Championships.
Horodecki meets once-beaten prospect Chris Saunders (9-1 MMA, 0-0 BFC) in the main-card opening bout of Saturday's Bellator 47 event, and "The Polish Hammer" says he's happy to be fighting in his native Ontario, Canada.
Actually, Horodecki is just happy to be fighting at all.
"It was absolute chaos," Horodecki recently told MMAjunkie.com Radio (www.mmajunkie.com/radio). "Last week, I was supposed to fight on a card called Border Wars in Windsor, Ontario, which is about an hour-and-a-half from where I live on the border of Detroit and Ontario. My opponent fell through, and then I went through about four or five opponents. It got eventually to the point where the Ontario Athletic Commission just scrapped my bout altogether.
"That happened the Monday before last, so I was kind of in a little bit of chaos because I had done a whole camp, and I was just a few days out from the fight and didn't have a fight."
It was a bit of a shock to the big-show veteran who was starting to adjust again to life on the regional stage. Fortunately for the Team Tompkins fighter, Bellator had a late opening on their schedule.
"Fortunately, my manager and my coach were able to get me on board the Bellator card," Horodecki said. "It's right down the street. I fought on a card here in Ontario at Casino Rama, where the show's going to be at. Everything just kind of worked out.
"One door closed, and another door opened. I'm going to use this opportunity to show my stuff."
Horodecki earned mixed results in a four-fight WEC run, as wins over Ed Ratcliff and Danny Downes were sandwiched between losses to Donald Cerrone and Anthony Njokuani. While that left his promotional record at a respectable 2-2, Horodecki was released when the WEC folded into the UFC.
The striking specialist returned to action this past April with a victory over David Castillo in an event that took place at Casino Rama, the same venue that hosts Saturday's Bellator card. Horodecki earned a submission win, flashing some of the newfound grappling skills that he's been working on during training sessions in Las Vegas, as well as his native Canada.
"I still like to punch and kick," Horodecki said. "That's my craft; that's my trade. But I've been working on my game and getting it all well-rounded to keep improving. I was happy to get the first submission win. Fortunately now, I've got a couple more behind it."
In Saunders, Horodecki fights a 25-year-old Californian with an impressive seven-fight win streak. A win could earn Horodecki a spot in an upcoming Bellator lightweight tournament, but the 20-fight veteran said he's not looking beyond the challenge that awaits him on Saturday night.
"We'll see what happens," Horodecki said. "Right now, I'm focusing on Chris. I'm focusing on getting this win. After that, I've already got another fight for September that was previously signed in Canada for the Freedom Fight promotion, which is Canada's longest-running promotion. But right now, I'm just focused on Saturday."
It's a crucial time for Horodecki. Despite having youth on his side, he's gone just 5-3 since opening his career at an impressive 12-0. With a multi-fight deal in place with Bellator, he may have found a new home, but he'll need to get results to keep his spot.
For Horodecki, who just two weeks ago thought he might be sidelined, future considerations are not a top priority. It's all about what happens in the cage on Saturday night.
"Right now, I'm just happy to be fighting on national TV, coast-to-coast," Horodecki said. "I'm very happy about that. Big fights are what I've always been in. I'm at home there. Just one fight at a time and keep looking for big shows and getting on big cards."
For more on Bellator 47, stay tuned to the MMA Rumors section of MMAjunkie.com.
MMAjunkie.com Radio broadcasts Monday-Friday at noon ET (9 a.m. PT) live from the Mandalay Bay Resort & Casino's Race & Sports Book. The show is hosted by Gorgeous George, MMAjunkie.com lead staff reporter John Morgan and producer Goze. For more information or to download past episodes, go to www.mmajunkie.com/radio.


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We first saw the UM175 back in April and now Verizon has released the EVDO USB Rev A Modem for use on their network. We will be comparing the UM175 against the other USB EVDO Modems in the coming days. Be sure to read our Verizon UM175 First Impression on EVDOinfo.com.
Related Links:
- Buy the Verizon UM175 with 2-year contract from 3GStore.com
- Discuss the Verizon UM175 on EVDOforums.com


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From Wikipedia: http://en.wikipedia.org/wiki/Ottawa_Convention_Centre#Construction
The Ottawa Convention Centre is a convention centre in downtown Ottawa, Ontario, Canada which opened in April 2011. The Centre replaces the Ottawa Congress Centre, which opened in 1985. The new centre is built on the site of the Congress Centre building, which was demolished in 2008-2009. The Centre is located on Colonel By Drive, just south of Rideau Street. The facility is owned by the Ontario provincial government.
The capital of Canada is Ottawa, in the province of Ontario. There are offically ten provinces and three territories in Canada, which is the second largest country in the world in terms of land area.While politically and legally an independant nation, the titular head of state for Canada is still Queen Elizabeth.On the east end of Canada, you have Montreal as the bastion of activity. Montreal is famous for two things, VICE magazine and the Montreal Jazz Festival. One is the bible of hipster life (disposable, of course) and the other is a world-famous event that draws more than two million people every summer. Quebec is a French speaking province that has almost seceded from Canada on several occasions, by the way..When you think of Canada, you think of . . . snow, right?But not on the West Coast. In Vancouver, it rains. And you'll find more of the population speaking Mandarin than French (but also Punjabi, Tagalog, Korean, Farsi, German, and much more).Like the other big cities in Canada, Vancouver is vividly multicultural and Vancouverites are very, very serious about their coffee.Your standard Vancouverite can be found attired head-to-toe in Lululemon gear, mainlining Cafe Artigiano Americanos (spot the irony for ten points).But here's a Vancouver secret only the coolest kids know: the best sandwiches in the city aren't found downtown. Actually, they're hidden in Edgemont Village at the foot of Grouse Mountain on the North Shore."It's actually worth coming to Canada for these sandwiches alone." -- Michelle Superle, VancouverText by Steve Smith.