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Panthers coach Ron Rivera acknowledged that his team might still be trying to fix one of the weakest spots on the roster.
Rivera confirmed last week's report that the Panthers were talking to veteran safety Quintin Mikell.
"Without getting into details, I think there's a little curiosity and that's about as much as I can say about that," Rivera told Joe Person of the Charlotte Observer. "He can play. He's a good football player. We'll see how things go. It's still early. We've got a couple weeks left to go."
The 32-year-old Mikell would be the favorite for a starting job if he signed with the Panthers, since they don't have much opposite free safety Charles Godfrey.
Mikell was released by the Rams in March, but has shown plenty of evidence that he's still capable of helping a team. Especially a team as thin at his position as the Panthers.


text:
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Sparta Prague and Slovan Bratislava face sanctions from UEFA, the governing body of European football, following crowd violence during their Europa League tie in Bratislava on Thursday night. The game was suspended for 40 minutes shortly before half time after violent exchanges occurred between fans of the teams. Sparta eventually won the game 3-0. The hosts now face stadium closure for failing to prevent the disturbances while Sparta's fans could be banned from travelling to their team's away games. Both clubs have condemned the incident. A verdict by UEFA's disciplinary committee is expected next week, the Czech FA said.
President Miloš Zeman is in China on the first official visit by a Czech head of state to the country in 10 years. Mr Zeman on Friday visited a trade show in Chengdu, the capital of the Sichuan province, and met with Chinese Vice Premier Ma Kai to discuss plans to launch a direct flight connection between their countries, a spokesman for the Czech president said. Mr Zeman is accompanied by a large business delegation which includes representatives of Czech industrial companies, universities, wine producers, legal firms, railway operators, and others. The Czech head of state is scheduled to meet with the Chinese president and prime minister on Monday, the last day of his Chinese visit.
A man convicted of last year's murder of an influential Social Democrat politician has been sentenced to 17.5 years in prison. The court said that the man, a former army officer, gunned down Roman Houska in front of his home in the northern city of Ústí nad Labem in what looked like an execution, and rejected the shooter's claims that he acted in self-defence. Media reports described the killing as a contract murder but the court said no motive had been established. However, if new evidence emerges, the authorities will act accordingly, the court said.
Top Czech tennis player Petra Kvitová lost to Caroline Wozniacki of Denmark 2-6 3-6 in the group stage of the WTA Finals in Singapore on Friday, and has been eliminated from the event. Kvitová went ahead at the start of both sets but lost her lead after a series of errors and poor serving. The 24-year-old Czech said she was exhausted but would be in shape for the Czech Fed Cup team's tie against Germany in Prague next month.
Renowned Romany musician Eugen Horváth died on Friday at the age of 74, the Museum of Romany Culture in Brno said. The Slovak-born Horváth, known as Janko, came from a musical family, and learned the play the violin at an early age. In 1969, he formed his own cimbalom band which recorded several albums including the 1992 record Gypsy Weeping.
The Czech Finance Ministry has lowered its forecast for this year's GDP growth to 2.4 percent, down from its previous estimate of 2.7 percent. The ministry said is cut the forecast due to revisions of the country's economic growth in the previous quarters as calculated according to a new European methodology, known as ESA 2010. In the next two years, the ministry expects the economy to grow by 2.5 percent, mainly because of growing domestic consumption.
Czech MPs on Friday voted to approve the government's civil service bill, overturning the president's veto of the legislation. The bill should depoliticize public administration and overhaul the rules for the employment of public servants. However, the president had earlier warned he would file a complaint with the Constitutional Court if the bill is approved. Mr Zeman criticized, among other things, the fact that the legislation formally introduces posts of politically appointed deputy ministers. A civil service bill was first adopted by the Czech Parliament in 2002 as a prerequisite for the country's accession to the EU but has never been implemented.
Trade unions at the Czech national carrier Czech Airlines have cancelled plans to go on strike next Thursday over lay-offs and salary cuts. The decision came after the firm's management promised on Friday to "limit the impact" of the restructuring. Earlier this week, the troubled firm announced salary cuts and massive layoffs; some 170 of the airline's 400 cabin crew members are set to lose their jobs under the plan. However, the agreement will not affect the basic features of the plan, Václav Řehoř, the head of Czech Airlines' mother company, Czech Aeroholding, said.
Five-year-old British cancer patient Ashya King received a final dose of
proton beam therapy on Friday, concluding his six-week long treatment at
Prague's Proton Therapy Centre, doctors at the facility said, adding that
the boy has coped well with the treatment and is now able to eat and sit by
himself and move his hands. The patient is now set to return to Spain for
rehabilitation. The physicians are optimistic about the boy's prognosis
but said they would only be able to say whether the treatment has been
successful in several moths' time.
Ashya King's story received international attention after his parents took him from a UK hospital in August without his doctors' consent. They took him to Spain where they were arrested before being allowed to come to Prague for the special treatment.
The lower house of the Czech Parliament has postponed a vote on controversial child care legislation. The bill would require all nurseries, kindergartens and informal babysitting groups to comply with strict hygiene rules which critics say would threaten their existence. It would also most likely lead to the closure of some 120 outdoor nurseries known as forest kindergartens. The bill, approved by MPs last month, returned to the lower house after a presidential veto and a new vote on the legislation was on Friday. But the coalition Christian Democrats said MPs should first determine whether the bill should be amended.


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LOS ANGELES, Feb. 13 (UPI) -- Former teen idol C. Thomas Howell says he is thrilled to make the transition from a recurring player to full-time cast member for Season 5 of the gritty Los Angeles cop drama, "Southland."
"Considering I was only supposed to be in the pilot, it's miraculous five years later to be part of the regular cast," Howell told United Press International in a recent phone interview.
"A lot of that has to do with luck and the show has changed a lot," the 46-year-old actor explained.
"Originally, we were a divided show between the detectives and the police officers and now we pretty much focus on the cops, other than Regina King's [Detective Lydia Adams] character. I think that had a lot to do with it. But, for me, it's an opportunity to do really good work, week in and week out.
"I've got a great relationship with the actors and a great relationship with the writers and my responsibility has changed a little bit in terms of you know where you're going to be for four or five months out of the year. It's just a wonderful opportunity to grow as an artist and grow as an actor. And, each and every week, come in and give it your best; that's been awesome."
Having a complicated, controversial character like police officer Bill "Dewey" Dudek to explore over an extended period of time is also greatly appealing, Howell said.
"It's a challenge each week," the actor acknowledged about his risky role. "He says things that make a lot of people cringe. At times, he's a racist. At times, he's not. At times, he's a misogynist. At times, he's not. There are times when he is very responsible and there are times when he's not. You never really know what you're going to get with him and I really find it a challenge each and every week to, in a way, do despicable things and say things that are unfair and unlikable, but there are times when I really try to find a balance within him. To do those things and still maintain a likability, and that's just been incredible as a performer and as an actor. I've really enjoyed coming to work and making those choices and finding a way to play a guy who might not always be likable, but make him lovable. That's the real challenge."
Howell said the working or retired police who are always on the show's set are a tremendous resource in helping the actors, producers and writers make "Southland" as authentic as possible.
"We are surrounded by real cops," Howell emphasized. "Any cop you see in a uniform outside of the four of us -- Shawn Hatosy, Michael Cudlitz, Benjamin McKenzie and myself -- all the other cops are all real cops, so there is a certain responsibility that we all feel and take very strongly to do the right thing. Whether we're kicking down a door and drawing our weapons or writing out a citation, there are certain dos and don'ts that come along with the responsibility of being a cop.
"We've got great technical advisers that are making sure we're doing the right things at all times. Most of our stories come from events that really happened, so many times we'll be in the middle of a scene and the cops we're working with will come up and say, 'Yeah, I remember when this happened four years ago.' ... And you hear the real account of what actually went down when you're shooting a sequence. So we're constantly reminded by the people who do this for a living, that are actually facing the opposite end of the barrel of a gun for a living. ... Every day when I go in, I'm so impressed by the people who do this for real and I feel a certain amount of responsibility toward them to do things properly and I think the rest of the cast would say the same thing."
Howell said he knows he and his collaborators are doing a good job because of the feedback they receive from real cops.
"The best of the best have really embraced the show," the actor said. "We have so much support from the Los Angeles Police Department and vice versa. I spend a lot of time hosting LAPD events and the rest of the cast does the same thing and we work with these people so closely now and I have so much more respect for police officers and what they do than when I started the show.
"I don't think the general public really knows what these people go through day in and day out. I sort of wish they had the experience we've had over the last few years to really understand that. Because there's a lot more respect I have for these people and for their jobs and the stress and the hardships they go through on a daily basis.
"You never know on a simple call -- whether it's a domestic violence call or pulling over a car -- you just never know if the person you're dealing with if it's their last day and they're going to go out in a blaze of glory and bring you down with them."
Howell is best known for his roles in the films "E.T.," "The Outsiders," "Red Dawn," "Soul Man" and "Secret Admirer," "The Hitcher," "Tank," "That Night," "Gettysburg," "Gods and Generals" and "The Amazing Spider-Man," as well as for his guest appearances on TV's "Hawaii Five-0," "Revolution" and "Castle."
He is married and the father of three children.
The 10-episode, fifth season of "Southland" is to kick off Wednesday night on TNT.


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UNESCO, Malian and international experts have completed the first assessment of damage to cultural heritage in Gao, following the occupation by armed groups of parts of northern Mali. Their work addressed both sites and the cultural practices of local people.
"Urgent measures are required to safeguard the Tomb of Askia World Heritage site before the next rainy season in June," said Lazare Eloundou Assomo, Director of UNESCO's Office in Bamako, who took part in the mission.
"Concerning Gao's heritage, we must address the trauma experienced by the local population following violent attempts by the armed extremists to destroy their cultural identity and practices, including traditional music. We must heal these wounds to pave the way for reconciliation and lasting peace in the region," Eloundou Assomo concluded.
Other participants in the mission to Gao included: Lassana Cissé, head of Mali's heritage department; Alain Crédeville, of the French Embassy in Bamako; and Sophie Ravier, head of the culture and environment unit of the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA)1, which facilitated this first assessment with transportation and security. 1
During the visit, the experts found that the local community had carried out work to repair the Tomb of Askia, to avoid further deterioration of the 15th century earthen monument. Young people of the town of Gao also took the risk of defending the site during the occupation, preventing the extremists from damaging it in the way they damaged World Heritage sites in Timbuktu.
Despite community efforts, the experts found that the mosque's prayer rooms require major conservation work before the next rainy season, to prevent further deterioration.
The experts also found that other cultural sites in Gao have deteriorated. Ninety percent of the archaeological site of Gao Saneye, which dates back to the 11th century, had been pillaged by the extremists. The newly built Sahel Museum, to which collections were to be transferred in March 2012, was used by the extremists as a residence for nearly one year, leading to the loss of equipment. This situation must be remedied before the collections can be transferred.
Collections housed in the old building of the Sahel Museum, including the Tuareg Imzad string instrument, whose practice was recently inscribed on UNESCO's Representative List of the Intangible Cultural Heritage of Humanity, were preserved in hiding by the museum's curator and staff.
During extensive consultations with local community representatives, the mission heard of the difficulties endured by the inhabitants, especially cultural groups, musicians and dancers, who saw their instruments burned and their equipment and costumes destroyed. The Takamba, a popular Songhoy dance, as well as the Holey-Orey, the dance of the possessed, were prohibited. Women were forced to cut their traditional braids and stop wearing traditional ethnic costumes. The House of Artisans was vandalized, leaving artisans without sources of income.
UNESCO and the Malian authorities will now work together to produce a complete needs assessment of the cultural heritage of Gao and take measures to safeguard that heritage.
Watch the video (b-roll)
See our photo gallery
Media Contact: Roni Amelan, UNESCO Press Service, r.amelan(at)unesco.org +33 (0)1 45 68 16 50
1 As well as: Youssouf Dembele, Secretary-General of UNESCO's National Commission for Mali; Thierry Joffroy, Director of CRAterre-ENSAG; Sebastien Diallo, ICOMOS expert, and Alpha Diop, conservation architect;


text:
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For those looking for an exciting career in Information Management across the Industries and Knowledge Organizations.
Admissions are now open under Cycle 1 for a multidisciplinary M.Tech 2010-2012 Programme in Information Systems and Management offered by the International School of Information Management (ISiM), University of Mysore in collaboration with some of the leading Information Schools across the globe - Dalhousie University, Canada; University of Michigan, USA; University of Pittsburgh, USA; Syracuse University, USA; International Institute of Information Technology, Bangalore and Informatics (India) Ltd., Bangalore.
What do we offer?
-> Cutting Edge Global Curriculum that imparts skill sets across the Information Management space Databases to Data Mining to Data Analytics; Information Retrieval to Information Systems Design to Software Systems Management; Taxonomy, Ontologies and Semantic Web to Human Computer Interaction. Check out our syllabus for details.
-> Unique opportunity to be mentored by Industry Leaders from Google, Yahoo, Intel and others through a path-breaking project - WikiGyan
-> Truly international learning experience with faculty drawn from our partner institutions. Course would be taught by world renowned experts from across the academia and industry
-> Need based Bridge courses
-> World class facilities a brand new well appointed 24 x 7 accessible Wi-Fi enabled infrastructure in sylvan setting
-> Internships and projects with leading industry partners
-> Informal but rigorous pedagogy
Who is eligible?
-> Engineering Graduates / 4-Year Degree Graduates (10+2+4) / Master Degree in any Discipline
-> CAT / MAT / GATE / PGCET / State Level National Entrance Test Score
Important Dates for Cycle 1 Admission:
Application Deadline : March 31, 2010
Offer Decision : April 15, 2010
Acceptance Decision : May 1, 2010
Course Start Date : September 1, 2010
For application forms and more details contact us at:
International School of Information Management
University of Mysore, Manasagangotri
Mysore 570 006
Tel: +91-821-2514699; +91-821-2411417
Mobile: Lohith - 9886772356
Fax: +91-821-2519209
No announcement yet.
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Lindsay Lohan may make her first formal return to the public eye since being released from jail on August 2.
According to E!'s Marc Malkin, the troubled starlet, who was sentenced to a 90-day jail sentence in July for repeatedly violating the terms of her parole stemming from a 2007 DUI case (of which she served 13 days), was reportedly seen at the Nokia Theatre on Friday during rehearsals for the 2010 MTV Video Music Awards.
VIEW THE PHOTOS: 2009 MTV Video Music Awards
U.S. & World
The "Machete" star's VMA appearance will reportedly address Lindsay's recent troubles, according to an E! source.
Reps for MTV were not immediately available for comment on a possible LiLo cameo when contacted by Access Hollywood.
VIEW THE PHOTOS: Lindsay Lohan Surrenders For Jail
Copyright 2010 by NBC Universal, Inc. All rights reserved.
This material may not be published, broadcast, rewritten or redistributed.
Related Content from AccessHollywood.com:
VIEW THE PHOTOS: The Trials & Tribulations Of Lindsay Lohan
VIEW THE PHOTOS: Lindsay Lohan's Day in Court (July 6, 2010)
PLAY IT NOW: Lindsay Leaves Rehab: What Happens Next?
PLAY IT NOW: Inside The Pages: Lindsay Lohan In Vanity Fair - Was The Fame Too Much To Handle?
More from Access: [ Lindsay Lohan MTV Video Music Awards Jail ]


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text: An explosion of the hottest colours in today's fashion. Silky soft with a highly almost metallic lustre. An absolute fashion statement. Hand tied with a poly blended special yarn for strength and easy maintenance. The pile on these rugs always stand upright and maintenance is easy as the pile won't shed like woollen shag rugs. Make this rug the new conversation point in your home or office.


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The workshop will be held from September 01st - 03rd 2017 at the Martin Luther University
Halle-Wittenberg, Germany
Dear colleagues,
Population aging in the 19th to 21st centuries is unprecedented in human history. Although average life expectancy is still increasing, we will have to confront the same degenerative diseases as in the last century. Within the world wide health systems, the major goal will change from just treating isolated single diseases to an increase in healthspan. Ageing is the most important common risk factor and the basis for most of the age-related chronic diseases. In model systems, we have learned a great deal about the mechanisms of ageing and are able to modify health as well as lifespan by genetic, pharmacological or lifestyle interventions. It will be the goal in the future to translate such results into humans.
The purpose of this meeting is (1) to discuss aging as a modifiable risk factor of diseases, (2) to promote greater communication among the world-wide community of individuals engaged in ageing research and (3) to invite young students to join this field of research.
The congress will be the 8th international meeting on ageing in Halle (Saale) and will accompany the development of a focus on ageing research in Central-Germany. It will comprise invited talks and poster sessions. There will be no concurrent sessions.
We are looking forward to welcoming you to Halle (Saale) for a most exciting and enjoyable meeting.
Andreas Simm
Prof. Dr. med. Hendrik Treede
Department of Cardiac Surgery
Martin-Luther University of Halle-Wittenberg
Ernst-Grube-Str. 40
D-06120 Halle/Germany
Prof. Dr. rer. nat. Andreas Simm
Department of Cardiac Surgery
Martin-Luther University of Halle-Wittenberg
Ernst-Grube-Str. 40
D-06120 Halle/Germany
Tel.: +49 (0) 345 557 2647
Fax: +49 (0) 345 557 7070
e-mail: andreas.simm(at)uk-halle.de


text: Peacebuilding Share on Facebook Share on Twitter Share by Email THEMESPEACEBUILDING Tearfund is committed to promoting peace and reconciliation, supporting activities that impact positively upon situations of conflict while safeguarding staff and project participants (Tearfund's Quality Standards). Tearfund aims to take a conflict-sensitive approach in all its work and has developed a number of resources to help conflict-sensitive programming, which is especially important in emergency response work. Tearfund has also produced some guidance on how to promote peace at the community level, which may be more appropriate to longer-term development programmes. Good practice and learningread more Publications and resourcesread more


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East Devon holiday guide
East Devon is a beautiful place to visit and has a wealth of beautiful countryside and coastal scenery. With top events and lots of activities throughout the year, there is something for the whole family.
Use our online guide to discover top towns and villages, plan family days out with the What's On Guide, visit stunning beaches and find out a bit more about local history.
East Devon Holiday News
Places to visit
Useful Links
Read Online
Read the Exmouth Journal e-edition E-edition


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Every house or office is recognized by postal address. When you send a postcard to someone, just write down the address and it will delivered by postman. It is the same with a machine. It has a unique address called IP address (Internet Protocol) address. When your machine send data to other machine, it will set the ip address as the destination.
My IP address is 192.168.0
If you see the number on above, there are four parts of number which are separated by 3 dots. Actually, each part of those number are Bytes that is is written into decimal number.
Is that what all we need to make our computer talk to the other computer?
If we do that, then it will bet not enough ip addresses for all computers in the world.
Then how is the trick?
All this connected computers are grouped. This group we know as LAN (Local Area Network). Then all these LANs are connected into a big network called Internet. We may say a minimum Internet is a connected two LANs and we are only part of small sub set of the entire network (internet).
Communicate to other computer in a different LAN.
When you send data to the other computer, it will check, "Am I in the same local network?" (or group as I said before)? The computer can not do this unless it has another parameter named 'netmask'.
Your computer will say:
"If I am in the same network with the destination computer that I want to send my data to, then I can continue the process."
Mean, "netmask" will be used to set the range of IP address that can be reached.
How combination of IP address and Netmask set the range of IP address?
Netmask consist of 4 bytes and written as decimal number, same like ip address.
Netmask: 255.255.255.0
Number 255 will say that your first byte, second byte and third byte of your ip address are the same with other computer.
So, the range will be:
Your IP: 192.168.0.1
Netmask: 255.255.255.0
Your range: 192.168.0.0 – 192.168.0.255 (see, that the 3 bytes from left to right are the same).
You IP: 192.168.45.125
Netmask: 255.255.0.0
Your range: 192.168.0.0 – 192.168.255.255 (see, that the 2 bytes from left to right are the same).
In a stand alone network, the netmask must be the same and all IP address must be in the same range.
PC-A IP: 192.168.0.10 Netmask: 255.255.255.0
PC-B IP: 192.168.0.2 Netmask: 255.255.255.0
PC-C IP: 192.168.0.200 Netmask: 255.255.255.0
If PC-A is not in the same netmask and IP range with PC-B and PC-C then PC-A will see the network in a different way.
PC-A IP: 192.168.2.10 Netmask: 255.255.0.0
PC-B IP: 192.168.0.2 Netmask: 255.255.255.0
PC-C IP: 192.168.0.200 Netmask: 255.255.255.0
PC-A can see PC-B and PC-C but PC-B and PC-C can't see PC-A.
Mean PC-A can not communicate with PC-B and PC-C.
The error message will be:
taufanlubis@zyrex:~$ ping 192.168.0.2
connect: Network is unreachable


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Soaring temperatures across most of Ukraine in recent days have slowed down traffic and kept people indoors during the daylight hours. Weather bureaus on July 19 say they expect the heatwave to continue into this week. Sunday, July 18, saw temperatures in Poltava reaching 36 Celsius (97Fahrenheit), breaking the 34 Celsius record set in 2007. The lowest recorded temperature for July 18 is 9 Celsius, recorded in 1911. Ukrainians were told that they should not expect cooler weather for at least two more weeks.
Monday, July 19, 2010
Record-high temperatures are forecast across Ukraine for July 19-25.
Posted by Oleg Bezverkhnii at 21:08
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text:
Senior Surveys
Click on the appropriate link to download the survey.
- CIRP CSS Graduating Senior Survey 2008-2012 Tables 1 - 18: **NEW 9-13-12** Tables show outcomes for Saint Mary's seniors graduating from Spring 2008 through Spring 2012 Includes National comparisons vs. 4-Year Catholic Colleges and vs. All 4-Year Private Colleges for 2012. Survey areas evaluated include general satisfaction items, satisfaction with campus services and facilities, self-reported of growth in learning skills/abilities, attitudes and behaviors related to diversity, and CIRP Construct scores (e.g. "Habits of Mind" score). Growth on CIRP Construct scores from the Freshman to Senior year for a matched group of students are included. TABLES 7-18 provide these statistics DISSAGGREGATED by GENDER, ETHNIC GROUP, and CATHOLIC vs. NOT CATHOLIC.
- CIRP-CSS Graduating Senior Survey SATISFACTION ITEMS 2007-2011 - Tables showing the percentage of Saint Mary's seniors graduating in the years Spring 2007 through Spring 2011 who are "satisfied" or "very satisified" on 12 items assessed on the CIRP College Senior Survey. Includes national comparisons with other 4-year Catholic colleges and ALL 4-year private colleges.
- CIRP CSS Graduating Senior Survey - Diversity Items SMC vs Other Catholic and Private Colleges
- CIRP-CSS Graduating Senior Survey Outcomes 2007-2011
Six tables showing Senior Satisifaction (Overall), Satisfaction with SMC Curriculum and Facilities, Self-Reported Growth in Skills/Abilities, Attitudes and Behaviors related to Diversity, and Mean Scores on CIRP Constructs. Data are displayed longitudinally 2007-2011 and include national comparisons with other 4-year Catholic colleges and ALL 4-year private colleges.
- Spring 2008 College Senior Survey


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A Farewell to 'Beyond School' Blog, as Coverage Finds a New Home
The Beyond School blog is retiring after a run of nearly three-and-a-half years.
The Beyond School blog is retiring after a run of nearly three-and-a-half years.
The schools will lengthen the day for 6th graders, who will receive extra literacy instruction, as well as enrichment and other academics.
The first of the schools in five states lengthening the school year by 300 hours are opening their doors for the new, longer year.
THINK Together, one of the largest extended learning providers in the country, acquires the Bay Area chapter of a national after-school organization.
Attention to the community schools model as a school turnaround strategy is growing.
The latest report in a five-year project on summer learning offers recommendations to districts aiming to offer high-quality summer programs.
Three summer programs have been selected out of a pool of 90 applicants for the National Summer Learning Association's annual award.
Growing attention is drawn to how to reduce academic losses over the summer months; expanded learning time seen as a solution by some.
Five cities will host summits with state and local leaders next year in support of after-school programs.
Students in Chicago earn virtual accolades for summer learning experiences at 140 organizations in the city.


text:
Reporting Day
Back at the ol' MLB.com condo here after spending the morning over at the Mattick for Toronto's reporting day for pitchers and catchers. The reporting date is kind of overblown, if you ask me. All this day means is players have to be in Florida — not at camp.
The real action will start on Monday, when all of the invited pitchers and catchers are required to be in camp for the first official workout. There's plenty of them around already, including Mr. Halladay (pictured right). That photo is from the AP wire — nice shot. I'll probably begin toting my camera to camp beginning on Monday. So keep checking back here for photos from around camp.
It was a pretty chill day today. Only three reporters and a few new faces around for the Jays. Ken Takahashi made his first appearance, as did GM J.P. Ricciardi and team prez Paul Beeston. I also saw Rod Barajas briefly before heading out to watch some of the pitchers work through drills.
I talked to Shaun Marcum today after he was done playing a light round of catch with one of the Jays' trainers. Marcum is throwing every other day right now and has been throwing since shortly after the Super Bowl. Seeing him and Dustin McGowan walking around is a constant reminder of what Toronto is missing, and the competition it's created this spring.
From our short meeting with J.P. today, we learned that the team isn't going to pencil Travis Snider into the Opening Day lineup just yet. Ricciardi said he could definitely envision a scenario in which the Jays feel Snider could benefit from more seasoning at Triple-A. That's one reason for the Millar signing, to help build a contingency plan.
If Snider begins the year at Triple-A, Adam Lind would be the starting left fielder and both Kevin Millar and Jose Bautista would likely make the team as well. With Snider and Lind in the fold, it's not clear whether the club would carry both Millar and Bautista, or if someone like Joe Inglett might be at risk.
As for any more spring additions:
"We'll see if there's anybody out there that we match up with in a trade," Ricciardi said. "I don't foresee it, because obviously the No. 1 thing we'd want to get is some kind of pitching and I just don't see that being in excess out there."
Discussing the rotation, Ricciardi said he's looking forward to seeing how the battle for the two vacancies plays out, with a mix of prospects, reclamation projects and holdovers vying for jobs. He did say that, on paper, the top five right now are Halladay (no kidding), Jesse Litsch, David Purcey, Casey Janssen and Scott Richmond.
As for Scott Downs being considered as a starter? No more. Said Ricciardi: "His heart's not in it. He doesn't want to do it, so we're probably better off keeping him at a comfort level." I say that's a smart move, because Downs is a big reason why Toronto's bullpen is as strong as it is right now.
Bench coach Brian Butterfield: "Hi, Scotty."
Scott Richmond, walking to the bullpen: "Hey."
Butterfield: "Hey? I haven't seen you all winter and all I get is 'Hey'?"
Richmond (laughing): "How are you doing today Butter?"
(a few minutes later, Brandon League walks by)
Butterfield: "Hi, Leaguer."
League: "Hey."
(Butter laughs and throws his arms in the air)
4 Comments
Jordan keep the posts coming.
In the long run having Travis Snider start in AAA wouldnt be the worst thing.
Glad to hear Downs is no longer being considered as a starter.
Sending Snider down to AAA sounds like JP getting his spin story ready for why he signed both Bautista and Millar. We're not going to make the playoffs this year and supposedly are preparing for 2011. So why in the world would we want to keep Millar-a guy who will turn 39 next year and who's skills are already in serious decline. I'd also like to see how much we've committed to pay Millar if he makes the team, that has been not suprisingly missing from any PR-why is that?
Snider is capable of becoming an elite hitter, maybe even one of the top 10 in the league. The issue is where will he get the best instruction and advance the best and fastest here or AAA. My take is Cito and crew are definately better for him than anyone we have at AAA. I think Cito and crew are one of the best hitting coaching groups in baseball.
If we really do want to get back into contention next year, both Snider and Arrencibia should be up here and give them two years under Cito-it will pay dividends for 10 or more years.
Our rotation looks like 2 through 5 on paper should be written in pencil.
We sent Litsch down last season, even though he was pitching very well at points. Who is to say he won't get sent down again if he struggles? Purcey and Richmond have only 17 MLB starts between them with a combined record of 4-9? Also, who knows what we are going to get from Janssen after a year off, and the previous year being primarily used in the bullpen?
Its going to be fun this spring! At least McGowan might be ready by May.
welikeroy- this will be a fun spring. This year is shaping up to be very simular to 2007. But who remembers ohka, zambrano, thompson. We will remember Listch, Mcgowan, marcum.I am confident that several pithcers will show they have the stuff to hold down a spot in 2010 and when Marcum and Mcgowan are ready to go we will have a surplus of pitching similar to 2008 and with a Cito enhanced offence anythings possible.
The question is who will be the break out pitchers of this season. my money is on Romero, and purcey.


text:
Thousands of Ghanaians packed Independence Square in the capital Wednesday to welcome their new president after an election so close that one small rural constituency held the key to victory for opposition candidate John Atta Mills.
Ghana's orderly transition of power is a bright spot after a dismal year for democracy in Africa. More than 1,000 Kenyans died in violent attacks that followed a disputed election 12 months ago. Kenya's crisis was followed by Zimbabwe's flawed elections, which resulted in a power-sharing agreement that has yet to be implemented. In Mauritania and Guinea, the military seized power from the elected governments.
"The election in Ghana is very important because the year started so badly with the violence in Kenya," says analyst Tom Cargill, assistant head of the Africa Program at the Chatham House, a research group in London. He points out that successful elections were held in Zambia last year, and in Sierra Leone in 2007. "The general trend is in a positive direction and Ghana is a continuation of that," he says.
Ghana has been embraced as an example to the continent's fledgling democracies. Kenya's prime minister, Raila Odinga, described Ghana as "a rare example of democracy at work in Africa." United Nations Secretary-General Ban Ki Moon called Ghana "an admirable example."
That the election was peaceful and transparent is all the more remarkable because the stakes were so high – revenue from reserves of 1.8 billion barrels of oil is expected to flow in 2010 – and the margin of victory was wafer-thin. Nine million votes were cast yet, only 41,000 – less than half a percent – separated Mr. Mills of the center-left National Democratic Congress (NDC) from his opponent Nana Akufo-Addo of the ruling center-right New Patriotic Party (NPP).
The winner was conciliatory in victory. "There is no NDC Ghana, there is no NPP Ghana .... There is one Ghana," Atta Mills told cheering supporters after official results were announced this past weekend. "I assure Ghanaians that I will be president for all," he added.
One Western diplomat in Accra pointed out that a close election does not have to be violent. "This is [more like] Florida, not Kenya," he said.
America's 2008 presidential election loomed large over Ghana's poll. Supporters of the two main parties talked of their dreams for an "Obama" – here meaning a first-round win – and analysts hoped that the loser would follow Sen. John McCain's example by conceding quickly and graciously. This Mr. Akufo-Addo did.
Emmanuel Gyimah-Boadi of the Ghana Centre for Democratic Development described the "mutual loathing and distrust" between the political rivals, yet it did not erupt into violence.
So why has Ghana succeeded where others so spectacularly fail?
Ghana's multiparty democracy is youthful but entrenched. Its unlikely progenitor was Jerry Rawlings, a serial coup organizer and military ruler. But in 1992 Mr. Rawlings reestablished multiparty democracy and there have been four elections since.
In 2000, Ghanaians voted for a change of government when Atta Mills, hand-picked by Rawlings, lost to John Kufuor, the outgoing president who handed over power Wednesday. That showed Ghanaians that their votes count and their politicians can be held accountable as Rawlings was, booted out for running a corrupt regime and a disastrous economy.
This time Mr. Kufuor's party was punished, say analysts, for failing to improve the lives of poor Ghanaians even as the economy grew at around 6 percent a year.
Also significant is Kufuor's willingness to abide by the law and leave office after two terms as demanded by the Constitution. Often in Africa, leaders are tempted to change the Constitution in order to stay in power.
Uganda's Yoweri Museveni, for example, changed the law rather than give up power as did Chad's Idriss Deby and Cameroon's Paul Biya. Zimbabwe's President Robert Mugabe shows no sign of giving up power after 28 years. Africa's longest-serving head of state is Omar Bongo of Gabon: 41 years in power, the country's only ruler since independence.
Unlike Kenya's electoral campaign, Ghana's politicians eschewed stoking ethnic divisions: they exist but remain in the background.
Ghanaians will tell visitors that they are proudly Ghanaian first; they are Ashanti, Fanti, Ga, or Ewé second. And they are aware that the continent was watching this election. "Here, we cannot be like in Kenya," said businessman John Ewusu, expressing a common sentiment during the elections.


text:
Check manual page of f5_bigip_cluster_status
F5 Big-IP: Active/Active or Passive/Active Cluster Status (< V11.2)
|official part of Check_MK
|Supported Agents:
The check queries the MIB tables of F5 BIG-IP loadbalancers (local traffic managers) to identify
if the cluster correctly runs in an active/active or an active/passive setup.
You can configure the expected behaviour via a WATO rule.
It will issue a warning if the cluster setup differs from the expected setup.
This check is expected to be run on cluster hosts, since it evaluates the state of multiple nodes.
If you run this check on a cluster node, it will raise no warning if the cluster node state
differs from active.
Since version 11.2 you are able to configure the node states. Default values are:
unknown will be treated as UNKNOWN, offline as CRIT, forced offline as CRIT,
standby as OK and active as OK.
One service is created.


text:
Thursday, February 24, 2011
Cleaner CDK Code #9: using the LoggingTool
Don't concatenate Strings when calling the LoggingTool
Logging in the CDK can be turned off, and in production use, I often do. Therefore, we can make it speed up by concatenating debug message String only when debugging is turned on. The CDK LoggingTool can take care of this, so you should pass the Strings are individual parameters to the logger call. Instead of:
logger.debug("the current atom is " + atom);
you should write:
logger.debug("the current atom is ", atom);
And this works for any arbitrary number of Strings and objects, because the logging tool debug method has this signature: public void debug(Object object, Object... objects). So, you can also just do:
logger.debug("The ", i, "th object is connected to the ", j, "th");
Actually, looking at the debug() method's signature, I am not sure why we still have the first Object separately... mmm.
Adding a CDK atom type
Most of you have already developed a love/hate relation with the CDKAtomTypeMatcher. This is the class that complains about atom types not being recognized. And let me stress this one more time. When you get such a method, it means that the CDK cannot add hydrogen, it cannot calculate QSAR descriptors, etc, etc. I have had the comment that CDK 1.0 never complained about that. True. It just ignored the fact that it did not know what to do with that atom, and calculated (wrong) properties anyway.
The solution to such a missing atom type warning can be two-fold. First, the input data was wrong, for example, because formal charges were lost at some point. A typical example is a neutral four-coordinated nitrogen. Second, the input data is correct and the CDK is wrong. This doesn't happen too often, but it does.
This last is the topic of this post. The CDK can be 'wrong' in two ways. Either it doesn't know the atom type (CDK 1.2 and 1.4 have more atom types than CDK 1.0 ever had; so), or the perception algorithm makes a mistake. The latter is not uncommon, particularly for some elements, like nitrogen. The cause here is the input data, or better, the lack of input data. Missing bond orders, missing explicit hydrogens. Now, cheminformatics can make educated guesses, and so the perception algorithm does. But it depends on its education.
Doing the needed education of the CDK basically looks like this commit. It adds:
- a new atom type to the ontology,
- adds code to the CDKAtomTypeMatcher for the perception, and
- adds unit tests to make sure it does the right thing.
- the element (duh),
- the formal charge,
- the number of bound neighbors,
- the number of double bond equivalents (piBondCount),
- the number of lone pairs, and
- the hybridization state (sp3, sp1, etc).
Monday, February 21, 2011
CKAN and RDF: a nice example of why ontologies matter
In fact, the Open Data definition as outlined in the Panton Principles does not allow for a non-commercial clause, which several LODD data sets are labeled with. Clear copyright and license statements are really important. This applies to source code, but most certainly to data too.
So, early March there will be a virtual, online hack session on making a start clarifying the licensing and copyrights of the various LODD data sets. CKAN, the OKF's registry of data sets sounds like a suitable place to organize things. And, they support RDF making it even a nicer match. Or...
Records, data sets, packages, lists, ...
Well, I am running into a number of problems that need to be solved. The first one is, in fact, rather fundamental. A record in the CKAN catalog is typed as a CatalogRecord. Nothing more, nothing less. However, looking at the database content each record is like a data set. The GUI confirms that with links like 'Add a dataset'. Then again, following the link, it is described as a 'data package' as well as a 'dataset'. This is confusing.
Yes, it is! Really! Just look at how people are using it.
Take for example the record for LODD (well, there is a second LODD record and I haven't found a way to delete records). But, the LODD data is not a single data set, but a aggregation (package?) of data sets. This is basically one of the standing issues with Linked Open Data: license incompatibilities, just like with mixing GPL v2 and v3 in source code. As such, these records which are basically lists of datasets typically not have a license listed, as multiple license apply.
There seem two solutions: the use of groups and of tags. I opted for a new W3C's HCLSIG LODD task force group.
Small issues
As said, I could not find a way yet to remove datasets, so cleaning up the catalog is a bit difficult. You can add comments, but I am not sure if these get read. Earlier, I noted that the GNU FDL license was missing, but that is available from the list now, so I have updated the NMRShiftDB record. The combination of Attribution and Share-Alike for the Creative Commons license is missing from the list though, affecting the ChEMBL record.
Another issue that must be addressed in CKAN is how to deal with redistributions. For example, the above cited ChEMBL data is also available as SPARQL end point by me, and this end point currently has a different record. Should those records be merged? I guess not, because there is only place for one maintainer. So, perhaps a CKAN catalog record is not even a dataset, but a data set provider?
Well, this does make a really nice example of what can go wrong if terms are not well-defined, e.g. using an ontology. People do not know how to fill the database, leading to noisy content, limiting the usefulness of the data. I do hope we get to see definitions for what groups and datasets are in the catalog before our hack session in March.
Thursday, February 17, 2011
OPSIN used for a Bioclipse wizard
Somewhere in January I added a new New Wizard to Bioclipse for OPSIN, but forgot to blog about that earlier, which will be available in Bioclipse 2.6 later this year (or just the hudson build service).
Science 3.0 needs a facelift before ...
It comes down to the fact that the website has way too much information, and uses way too much space for things that do not matter. The interesting content only starts half-way my screen. I tend to have given up finding the interesting bits by then.
But even within each thread there is room for improvement. There too, there is abundant whitespace, though that might prove functional when the layout becomes more compact. Also, I life the photo of the people whom I follow to be removed (something that is done with a userscript only on FriendFeed too!). Instead, it should be clear where to thread comes from. (Regarding that, I am not sure if any RSS feed you can now list, will actually show up in this activity stream yet.)
"Fill in the #Wikipedia Survey and Help Our Community"
As a nice spin-off if gives you a star rating for how well you are into the social science networks:
I got eleven stars, but that should not surprise you.
Monday, February 14, 2011
Things are looking blue... (for #bioclipse)
Last Friday a virus kicked in. Don't know whether flu or cold, but it had already ruined my 5-6 February weekend too. I need high fever to keep bed, otherwise I just can't. Worse, when having an elevated temperature, I cannot think clearly anymore, and I haven't been able to think clear since about last Wednesday, so I should have seen it coming. Nor can I think clear today, leading to incomprehensibly question on BioStar, and the general lack of progress in writing and other important things, like planning.
Sunday, February 13, 2011
Bioclipse upgraded to CDK 1.3.8 and CDK-JChemPaint 17: builds broken
Well, and I got them wrong. A few things had to happen. First of all, I had to revert the JNI-InChI library to a plugin, as I have no experience with making OSGi bundles out of random jars (there is this bnd tool which exists for that task, but never used it before). But, the upgrade brought in version 0.7 which should solve the InChI library loading issue, as well as bring InChI to various more platforms. So, the JNI-InChI jar was pulled from the target platform, and the rebuild worked out of the box.
The second thing I did was upgrade the org.openscience.cdk bundles. This repository had three branches, one for pure CDK, now updated to CDK 1.3.8, a CDK-JChemPaint branch updated to version 17, and a bioclipse2.4 branch for Bioclipse 2.x (we now and then patch things to make it work, so that we do not have to wait for them to be applied upstream, with the CDK itself). I thought it would be good to create a separate bioclipse2.6 branch for Bioclipse master, but that was a mistake. This branch information is scattered over the .rmap and .cquery files, and they are not all in one single git repository, and those that are, are not synchronized with the versions on Hudson either. It's normal in prototyping, but not helping me. After a couple of hours fiddling, I got this one compiling too.
Right now, I'm stuck with getting bioclipse.cheminformatics compiling again, and looking for ERRORs in an enormous log file. If only ERROR messages were a bit more descriptive, something like "Hej, you said to look for org.openscience.cdk.sinchi in file foo.bar, but I cannot find it anywhere.", then I'd have some clue where to look.
That makes me wonder if anyone actually ever wrote up best practices for error messages...
BTW, I also still have another, independent dependency issue to solve: the one for Google's Guava, so that everyone can play with the Bioclipse-Google interaction.
Wednesday, February 09, 2011
Chemical data curation: yes, it is that bad.
If we are in the field of property prediction, knowing what tautomer to calculate descriptors for is crucial. Not that we actually have easy access to experimental data showing what the important tautomer is for our end-point (predicted property), but at least we can track what tautomer we modeled with. Has everyone ever asked you to add units to experimental values? Like "the temperarature was 279 degrees; Celsius or Kelvin??" Well, this is the exact same thing. If your QSAR model training report does not include that information, you are doing it wrong. (/me ducks)
So, why does it in fact matter? It matter simply because calculated properties are different. Backing up to the ChemSpider example in my question about InChIs with the fixed-hydrogen layer I noted that (like in many other databases) the synonyms seems to include IUPAC names for at least two tautomers. However, while the ChemSpider is, in fact, for the tautomer-independent structure (using the InChI mobile hydrogen layer; and keep in mind that the InChI uses only a limited amount of heuristic rules for identifying tautomers, making it not detect all 40 tautomers of warfarin), the 2D diagram, the 3D model, and the calculated properties reflect only one tautomer.
And calculated properties are exactly the input in QSAR's statistical modeling. It is interesting to realize that the differences in calculated molecular descriptors can vary both minimally, or not at all, as drastically. Very drastically, in fact. The recent paper by Porter (doi:10.1007/s10822-010-9335-7) shows the 40 warfarin tautomers, and discusses a few properties, such as the pKa. The experimental pKa of warfarin is around 5. Now, the paper reports calculated pKa values for a variety of software products (AMBIT is unfortunately missing). First of all, it shows that the various tools differ, which is to be expected. But that variance is neglectable when compared by the effect of picking the wrong tautomer. I was impressed by the range of predicted values for the various tautomers. I ranged from about 5 to 12, throughout all tools. That means warfarin is predicted to be mildly acidic (some tools predict pKa's down to 2.5) to very basic! No way your statistical modeling will understand that!
And this is why Open Data is so important in chemistry. So, the next time Joe (Organic) Chemist bitches about computers and cheminformatics, tell him it is his own fault: he should have released his data out in the Open.
Anyway. Tautomerism was a curation issue in the first(!!!) entry I was curating. The sixth had the more well-known problem, I think. I may be blind, but I would say this drug has a stereocenter:
But none of the databases I checked so far (including ChemSpider) defines the stereochemistry! I thought we settled that some decades ago? Stereochemistry of drugs matter. What is going on here? I guess I have to browse some primary literature and access some experimental data today then. If I can afford it.
Porter, W. (2010). Warfarin: history, tautomerism and activity Journal of Computer-Aided Molecular Design, 24 (6-7), 553-573 DOI: 10.1007/s10822-010-9335-7
Sunday, February 06, 2011
Groovy Cheminformatics...
Some project are never finished. Neither is this one, but it is never too late to change how things work, so, taking advantage of publishing-on-demand, here I introduce the release-soon, release-often equivalent of cheminformatics books, my Groovy Cheminformatics with the Chemistry Development Kit book:
With a serious discount for just being the first edition (1.3.8-0), but still counting at 72 pages with 75 code examples, this edition marks a personal milestone (and probably not much more than that). There remains much to do, but I promised a release by tomorrow, so here it is. Next releases will contain more code examples, more functionality descriptions, and more literature reviewing where such code is used in science. The plan is to make new editions with each new CDK release, as well as new editions when I added a new chapter, section, or just paragraph. But, there will not be a Nightly build service anytime soon.
The current table of content is as follows:
Now, the book content is not open content. However, it contains nothing that is not available in other means. It's just the compilation that makes this book interesting, as well as that I put effort in ensuring the code examples remain working. For that, I ask a minor financial contribution.
Wednesday, February 02, 2011
Accessing Google Spreadsheets from Bioclipse
I am almost done refactoring two year old code for the Open Notebook Science Solubility project, which converted its data from the Google Spreadsheet into RDF, for the Beautiful Data book chapter.
Open Chemical Data #2: Dryad
About 1.5 years ago I started a FriedFeed room Open Chemical Data where RSS feeds of new chemical data are aggregated. It started with the RSS feed from the NMRShiftDB, and later ChemPedia Substances was added (which is expected to go EOL). I was informed, however, about Dryad. It is a website that allows deposition of data published in journals, as CC0. That latter is amazing! And when they announced a new twitter feed, also noted they had a RSS feed of new data sets. I asked about feeds specific for chemistry, which prompted Ryan to set up this Yahoo Pipe.
So, Dryad is now part of the Open Chemical Data room (second item):
Integrating CiteULike in LaTeX-based paper writing
book.bib: @echo "" > book.bib @wget -O - http://www.citeulike.org/bibtex/group/14384 >> book.bib
BTW, does anyone have experience with the new biblatex?
Tuesday, February 01, 2011
DIY: Running R from within Bioclipse
Arvid has done an excellent job in setting up Hudson for Bioclipse, which is not so trivial as for Maven projects. With the R functionality I blogged about earlier today moved to the bioclipse.statistics repository, things are automatically build when new patches hit the repository. And Hudson doesn't just compile the code, it also exports binaries. The main Bioclipse products build can be downloaded here (Windows, Linux, OS/X; if you need more, please let use know). And, all the additional features got automatically uploaded to individual update sites, very much like Maven projects getting pushed to a Maven repository.
So, here's an Bioclipse-R install guide for the adventurous (i.e. Christian, Rajarshi and Rebecca, perhaps Juuso :). I will describe it from a Debian GNU/Linux perspective.
First, make sure you have R and rJava installed. I strongly recommend the versions from sid/unstable (2.12 and 0.8-8), which are more stable here than those from testing:
$ apt-get install r-base-core/sid r-cran-rjava/sidThen you download the nightly build of Bioclipse 2.5.x from Hudson, e.g. for my 32bit Linux:
$ cd /tmp $ wget http://pele.farmbio.uu.se/hudson/job/Bioclipse.product/lastSuccessfulBuild/artifact/tmp/bioclipse/net.bioclipse.platform_feature_2.4.0-eclipse.feature/Bioclipse.2.5.0.linux.gtk.x86.zip $ unzip Bioclipse.2.5.0.linux.gtk.x86.zip $ cd Bioclipse.2.5.0.linux.gtk.x86/But before we boot Bioclipse, we first need to tell it where to find the R instance, and we need to set two variables for that: R_HOME and java.library.path. The latter is set via the bioclipse.ini file, by adding this line to the end:
-Djava.library.path=/usr/lib/R/site-library/rJava/jriThe other is an environment variable and can be set with:
$ export R_HOME=//usr/lib/RThen Bioclipse can be started:
$ ./bioclipseThe first thing to do is install the R Feature. To do this open the Install New Software... dialog from the Help menu, and add (with the Add button) the Bioclipse Statistics update site on Hudson at this Location (copy/paste the Location URL into the below dialog):
After the install is completed, which will require a reboot of Bioclipse (why?!?!), you can open the R console by opening a dialog from the Window -> Show View -> Other... menu:
The R Console will then show up as view, as depicted in my earlier post.
Loading of libraries, like running library("rcdk") or library("pls"), crashes the whole thing if you use R and rJava from Debian testing, and silently fails with those from unstable. It's on my agenda.
Running R from within Bioclipse
One rarely know feature of Bioclipse is that you use it to run R code. This functionality has been around for a while from experimental, and recently updated to use rJava by Carl. In the next months we will improve passing around data between Bioclipse and the R session, providing a richer chemometrics experience. And, with a bit of luck, it will be part of the upcoming 2.6 release.


text:
A step ahead
As powerful and attractive as never before. With the sapphire, a mixing console has become available that combines the best of both worlds. Our latest console for radio broadcast is not limited to proven cutting-edge technology but also offers an eye-catching new design.
The advantage: while technicians will be convinced by the possibility of various upgrades, maximum flexibility and sophisticated functionality, radio broadcasters will be continually impressed by the modern, clearly laid out control surface, which makes working with the new sapphire fun. In addition, the sapphire offers everything expected from a powerful mixing console: top quality, intuitive user guidance and clever solutions, all of which guarantee even greater working efficiency.
Modular technology - Today's intelligent solution.
Your individual requirements will determine which sapphire configuration is the right one for you. All you need to start broadcasting is a central module, a channel module and a couple of interfaces. However, the sapphire is also able to meet more demanding needs — with the addition of more channel modules, a sapphire can be transformed into a true production mixing console, placing a total of 60 faders at your finger tips.
But potential configurations go beyond the console's surface. A specific example: Level and control options are displayed directly above the respective channel in the overbridge, offering more ease of use and the best possible workflow in daily productions.
Control Panel
- Available as desk top or integrated version
- Up to 60 motorised 100 mm faders
- Operation possible with multiple operating layers (multi-layer, up to 120 virtual faders)
- Panel version with rotary and key extensions available as upgrade
- Optional visual extension with multitouch function to display channel levels and operation modules
System core
- Modular plug-in card system based on the DALLIS I/O system
- Central motherboard with integrated control system and signal processing (redundantly designed as an option)
- Integrated matrix with up to 512 inputs and outputs (non-blocking, 384 MADI + 128 DALLIS I/O slots)
- PC-independent and fan-free operation
- Optional redundant power supply
Signal Processing
- Integrated routing matrix, 768x768 crosspoints, non-blocking, transparent routing
- 96 mono DSP input channels (stereo, surround or simulcast coupling possible) with input gain, panpot / balance, direct out and insert
- 128 DSP modules ( 96 on input channels, 32 on sums, coupling possible like input channels)
- EQ (3 fully parametric bands and 2 filters)
- Dynamic units (gate , expander and compressor)
- Limiter
- Delay (up to 340 ms with switchable units: metres, ms or frames
- 80 mono summing busses (stereo or 5.1 coupling possible)
- 500 metres (mono, stereo and surround coupling possible) with loudness function on sums and channels
- 64 mini-mixers
- 32 DeEssers (mono)
- Integrated Intercom matrix with up to 64 talkback stations
- Analog Mic / Line (transformer or el. balanced)
- Headset (incl. VCA interface)
- AES / EBU (AES3) with and without sampling rate converter (SRC)
- ADAT® (ADAT® is a registered trademark of Alesis, LLC and is used here under license.)
- Serial data transfer (RS232, RS422, MIDI)
- GPIO (OC, Relay, VCA)
- 2 or 6 MADI ports on the masterboard
- IP codec
- AES67/RAVENNA Audio-over-IP option
- Wordclock input and internal generator
- Optional via MADI
- Supported sample rates 48 kHz and 44.1 kHz
- Up to 5 PFL busses
- Surround sources (5.1 or 5.1+2) and busses (5.1)
- Integrated mix-minus /conference logic
- Freely programmable logic core (redlight, faderstart, program switch, TB integration, etc.)
- IP-based and serial interface for interaction with radio automation systems ("sapphire" operating mode)
- IP-based and serial interface for matrix control ("Nova17" operating mode)
- Controller and Routing matrix optionally redundant
- Ember+ interface for integration with master control systems
- Optional MIDI interface for interaction with audio workstations (HUI protocol e. g. for ProTools™)
- Remote control of external Lawo matrices possible (e. g. source selection)
- Optional control via touch screen (VisTool)
- Optional graphic matrix control (NovaConnect)
Configuration and Maintenance
- Software for system configuration and logic programming
- Remote control of nearly all console functions with the help of VisTool, also via VPN
- Integrated web server for system diagnosis
- Dedicated SW tool for performing software updates
- Remote maintenance via IP
Subject to change without prior notice, no responsibility is taken for the correctness of the details provided.


text: Underpads and drypads are absorbent, protective healthcare essentials that are especially welcome at home. Shop our extensive selection in different weights, absorbencies and sizes for wheelchairs, chairs, floors, surfaces and beds. Underpads can be used on beds to protect bedding and mattresses from unexpected leaks, on baby changing tables, on bathroom floors where toddlers are potty training and even on the kitchen floor as a puppy pad. If you're dealing with a loved one's incontinence, you'll want try our true hospital-quality drypads Medline Ultrasorbs, Extrasorbs and Therasorbs which offer ultimate absorbency and protection. Because all of these items were originally created for hospital and healthcare use, many are available in convenient bulk quantities.


text:
Prednisolone Priming Study in Patients With Chronic Hepatitis B
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00778596
Recruitment Status : Unknown
Verified May 2012 by Yun-Fan Liaw, Chang Gung Memorial Hospital.
Recruitment status was: Recruiting
First Posted : October 23, 2008
Last Update Posted : May 25, 2012
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Study purpose:
To investigate whether ALT rebound following corticosteroid priming enhances response to telbivudine therapy.
Efficacy assessments:
The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without prednisolone priming.
Data analysis:
A summary table will be presented as frequency tables for categorical variables as number, and percentage, whereas descriptive tables for continuous variables as number, mean ± SD and median (minimum, maximum). All statistical assessments will be two-sided and evaluated at significance level of 0.05. Continuous variables will be analyzed using t-test, or ANOVA, and categorical variables will be analyzed using chi-square or Fisher's exact test. A non-parametric method, Wilcoxon rank-sum or sign-rank tests will be conducted for continuous, and categorical variables if data is far from normal distribution.
|Condition or disease
|Chronic Hepatitis B
|Drug: Prednisolone Drug: Placebo priming
|Phase 4
This is a Phase IV, multi-center, double-blinded, placebo control randomized study to evaluate the therapeutic effect of telbivudine with or without prednisolone priming in patients with chronic hepatitis B.
Patients are allocated to either group A or B randomly.
Group A: Patients initially receive a 4-week course of oral prednisolone (30 mg daily for 3 weeks and then 15 mg daily of 1 week). After a rest period of no treatment for 2 weeks, the patients receive telbivudine therapy at a daily dose of 600 mg for 2 years. Patients will be asked to come back to clinic for follow-up 6 months after telbivudine treatment.
Group B: Patients receive a 4-week course of placebo. After a rest period of no treatment for 2 weeks, the patients receive telbivudine therapy at a daily dose of 600 mg for 2 years. Patients will be asked to come back to clinic for follow-up 6 months after telbivudine treatment.
Eligible patients will be randomized prior to the first dose of study medication. The visit at which the patient receives the first dose will be defined as the study Baseline. Patients will return to the clinic at 3, 4, 6, 10, 14, 18, 30, 44, 58, 72, 86, 98, 110, 116, 122, 128 and 134 weeks post-Baseline. At each of these visits, routine clinical laboratory tests, adverse event inquiry, and other clinical assessments will be performed. Serum samples for HBV DNA analysis will be obtained at 4, 6, 30, 58, 86, 110 and 134 weeks. Serum samples for HBV sequencing will be obtained at Screening and Week 110 (or upon early termination from the study).
Complete physical examinations will be performed at each study visits to evaluate any adverse signs or symptoms reported by the patient.
Serum for HBeAg, antibody to HBeAg (HBeAb), HBsAg, and antibody to HBsAg (HBsAb) will be obtained at Screening, Baseline, and Weeks 6, 30, 58, 86, 110 and 134(or upon early termination from the study), and at all protocol-required follow-up visits.
Patients will be followed monthly for 6 months after discontinuation of study drug(s).
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|160 participants
|Intervention Model:
|Parallel Assignment
|Double (Participant, Investigator)
|Primary Purpose:
|Official Title:
|A Randomized, Double Blind Controlled Trial to Evaluate the Therapeutic Effect of Telbivudine With or Without Prednisolone Priming in Patients With Chronic Hepatitis B
|Study Start Date :
|February 2009
|Estimated Primary Completion Date :
|December 2012
|Estimated Study Completion Date :
|December 2013
Experimental: Prednisolone priming
Prednisolone priming 4 weeks, then treated with telbivudine.
Drug: Prednisolone
Prednisolone priming for 4 weeks, then followed a telbivudine treatment for 2 years.
Placebo Comparator: Placebo priming
Placebo priming for 4 weeks, then followed a telbivudine treatment for 2 years.
Drug: Placebo priming
Prednisolone priming for 4 weeks, then followed a telbivudine treatment for 2 years.
Other Name: Placebo
- The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without prednisolone priming. [ Time Frame: 1 year ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Treatment naïve patients or interferon-treated patients 6 months before, or oral antiviral agents treatment ≦ 2 weeks before or treatment < 3 months 1 year prior to screening.
- Male or female, 18 to 65 years of age.
Documented chronic hepatitis B defined by all of the following:
- Clinical history compatible with compensated chronic hepatitis B.
- Detectable serum hepatitis B surface antigen (HBsAg) >6 months and at the screening visit.
- Hepatitis B e antigen (HBeAg) positive >3 months.
- Serum HBV DNA > 2x10^5 IU/mL and raised serum ALT > 2xULN but < 5xULN determined on at least 2 occasions 1 month apart before screen or within 3 months of pre-screen, raised serum ALT > 2xULN but < 5xULN determined 1 month apart before screen and at screen.4.
- Liver biopsy showing chronic hepatitis and fibrosis stage ≦ 4 by Ishak classification within 6 months or fibrosis ≦ 4 between 6 to 12 months plus platelet count ≧ 150,000/mm3 or noninvasive assessment (fibroscan or ARFI) of liver fibrosis to excluding liver cirrhosis within 6 months.
- Willing and able to comply with the study drug regimen and all other study requirements.
- Willing and able to provide written informed consent to participate in the study.
Exclusion Criteria:
Patients will be excluded from the study for any of the following reasons:
- Pregnant or nursing.
- Of reproductive potential (men and women) and unwilling to use double-barrier method of contraception (i.e., condom with spermicide or diaphragm with spermicide).
- Co-infection with hepatitis C virus (HCV), hepatitis D virus (HDV), or HIV.
- History or clinical signs/symptoms of hepatic decompensation or portal hypertension, such as ascites, presence of esophageal varices or variceal bleeding, hepatic encephalopathy, or spontaneous bacterial peritonitis.
- Liver cirrhosis (Ishak fibrosis score 5 or 6).
- Any medical condition that requires prolonged or frequent use of systemic acyclovir or famciclovir (e.g., for recurrent herpes virus infections).
- History of hepatocellular carcinoma (HCC) or findings suggestive of possible HCC, such as suspicious foci on imaging studies or elevated serum alpha-fetoprotein (AFP) levels. A history of treated malignancy other than HCC is allowable if the patient's malignancy has been in complete remission, off chemotherapy and without additional surgical intervention, during the preceding 3 years.
- One or more known primary or secondary causes of liver disease other than hepatitis B (e.g., alcoholism, non-alcoholic steatohepatitis, autoimmune hepatitis, malignancy with hepatic involvement, hemochromatosis, alpha-1 antitrypsin deficiency, Wilson's disease, other congenital or metabolic conditions affecting the liver, congestive heart failure or other severe cardiopulmonary disease). Gilbert's syndrome and Dubin-Johnson syndrome will not exclude patients from participation in this trial.
- History of clinically evident pancreatitis.
- Currently abusing alcohol (i.e., an average daily intake of more than 40 g of ethanol) or illicit drugs or a history of alcohol abuse or illicit substance abuse within the preceding 2 years. Patients currently on methadone maintenance treatment programs are NOT eligible.
- A medical condition that requires frequent or prolonged use of systemic corticosteroids (e.g., severe asthma, severe arthritis or autoimmune conditions, organ transplantation, adrenal insufficiency).
- A medical condition requiring the chronic or prolonged use of potentially hepatotoxic drugs (dapsone, erythromycin, fluconazole, ketoconazole, rifampin, anti-tuberculosis regimens, etc.). All such drugs must have been discontinued ≥ 30 days prior to randomization.
- A medical condition requiring use of nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, foscarnet, vancomycin, cyclosporine, tacrolimus, or frequent nonsteroidal anti-inflammatory drugs (NSAIDS) or aspirin [administered daily for more than one week at a scheduled dose intended for anti-inflammatory therapy]). All such drugs must have been discontinued ≥ 30 days prior to randomization.
- Any other concurrent medical or psychosocial condition likely to preclude compliance with the schedule of evaluations in the protocol or likely to confound the efficacy or safety observations of the study.
- Enrolled or planning to enroll in another clinical trial of an investigational agent while participating in this study.
Any of the following laboratory values at Screening:
- Hemoglobin (Hb) <11 mg/dL for men or <10 mg/dL for women.
- Total white blood cell count (WBC) <2,500/mm3.
- Absolute neutrophil count (ANC) <1,500/mm3.
- Platelet count <75,000/mm3.
- Serum albumin <3.2 g/dL.
- Total bilirubin ≥2 mg/dL with direct bilirubin > 50% of total bilirubin.
- Serum creatinine >1.0 x ULN.
- Alpha-fetoprotein (AFP) >50 ng/mL (requires further evaluation, to rule-out hepatocellular carcinoma)
- Creatinine clearance (CrCl) <0.83 mL/sec (<50 mL/min) calculated by the laboratory using the modified Cockcroft-Gault method.
- Serum amylase or lipase ³1.5 x ULN.
- Prothrombin time (PT) prolonged by >3 seconds or International Normalized Ratio (INR) > 1.5, based on the upper limits of normal (ULN) of the reference value, despite vitamin K administration.
- Use of any investigational drugs within 30 days or 5 half-lives of randomization, whichever is longer.
- Systemic malignancy within 5 years.
- Previous treatment with telbivudine.
- History of hypersensitivity to components of either telbivudine formulations, or to drugs with similar chemical structures.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00778596
|Contact: Mei-Hsia Ku, MS
|+886-3-3281200 ext 8114
|Chang Gung Memorial Hospital - Chiayi
|Chiayi County, Taiwan
|Contact: Hui-Ching Chuang, BS +886-5-3621000 ext 2005
|Principal Investigator: Shui-Yi Dong, MD
|Chang Gung Memorial Hospital - Kaohsiung
|Not yet recruiting
|Kaohsiung City, Taiwan
|Contact: Chiu-Rong Chen, BS +886-7-7317123 ext 8301
|Principal Investigator: Chuan-Mo Lee, MD
|Chang Gung Memorial Hospital - Keelung
|Keelung City, Taiwan
|Contact: Yi-Ling Chen, BS +886-2-24313131 ext 3181
|Principal Investigator: Rong-Nan Chien, MD
|Chang Gung Memorial Hospital
|Linkou, Taoyuan County, Taiwan, 333
|Contact: Mei-Hsia Ku, MS +886-3-3281200 ext 8114 firstname.lastname@example.com
|Principal Investigator: Yun-Fan Liaw, MD
|Principal Investigator:
|Yun-Fan Liaw, MD
|Chang Gung Memorial Hospital
|Responsible Party:
|Yun-Fan Liaw, Chang Gung Memorial Hospital
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|October 23, 2008 Key Record Dates
|Last Update Posted:
|May 25, 2012
|Last Verified:
|May 2012
Hepatitis B
Hepatitis A
Hepatitis B
Hepatitis B, Chronic
Hepatitis, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepadnaviridae Infections
DNA Virus Infections
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal
Antineoplastic Agents


text:
Very good Murno.
A good walk at the start and some good rock jumping as you get near the top.
As always in this country - Awesome views!!
Travel and Coronavirus
Please check current coronavirus restrictions before travelling within or to Scotland.
Click for details
Share your personal walking route experiences in Scotland, and comment on other peoples' reports.
Warning Please note that hillwalking when there is snow lying requires an ice-axe, crampons and the knowledge, experience and skill to use them correctly. Summer routes may not be viable or appropriate in winter. See winter information on our skills and safety pages for more information.


text:
Maybe you've read Toronto Star columnist Catherine Porter's account of my encounter with her and her daughter at Sunday's Queen's Park protest. The trouble is, the central facts of Porter's story are not accurate. And we have the video to prove it.
Porter writes that her 9-year-old daughter Lyla saw me "belittling" someone about global warming, and that Lyla "was preparing to brawl with Levant" and that we had a "fight".
But that's just not true.
Porter tried to set up some sort of teachable moment between her daughter and me, but it just didn't happen.
So she made up the facts she wanted.
It doesn't really matter to me – I've had worse things said about me, by better people.
As I said in my earlier report, I had a great time at the protest. I met a lot of colourful people. I had some lively debates. But no fights or brawls.
I met some really weird people, to be sure.
But to be honest, the weirdest person I met was Catherine Porter, who demanded I talk to her young daughter, and then told a tall tale about it in the newspaper.
PS: Here's the shorter "highlight reel" of my conversation with Porter and her daughter:
UPDATE: On July 17, the Toronto Star's Public Editor, Kathy English, wrote a full-page piece in the paper, acknowledging errors in Porter's report:
UPDATE: On July 22, Catherine Porter's "apology" to me appeared in the Toronto Star.
I wasn't impressed:
Get the unfiltered truth the media party won't tell you:
JOIN TheRebel.media for more fearless news and commentary you won't find anywhere else.
READ Ezra Levant's bestselling books debunking environmentalist propaganda against the energy industry:
Groundswell: The Case for Fracking
Ethical Oil: The Case for Canada's Oil Sands


text:
Austrian National Space Law
- Cordula SteinkoglerCordula SteinkoglerInstitute for European Law, International Law and Comparative Law, Universitat Wein
This is an advance summary of a forthcoming article in the Oxford Encyclopedia of Planetary Science. Please check back later for the full article.
The Austrian Outer Space Act, which entered into force in December 2011; and the Austrian Outer Space Regulation, which has been in force since February 2015, form the legal framework for Austrian national space activities. The elaboration of national space legislation became necessary to ensure compliance with Austria's obligations as State Party to the five United Nations Space Treaties when the first two Austrian satellites were launched in 2012 and Austria became a launching state on its own. The legislation comprehensively regulates legal aspects related to space activities, such as authorization, supervision, and termination of space activities; registration and transfer of space objects; recourse of the government against the operator; as well as implementation of the law and sanctions for its infringement. One of the main purposes of the law is to ensure the authorization of national space activities. The Outer Space Act sets forth the main conditions for authorization, which inter alia refer to the expertise of the operator; requirements for orbital positions and frequency assignments; space debris mitigation, insurance requirements, and the safeguard of public order; public health; national security as well as Austrian foreign policy interests; and international law obligations. The Austrian Outer Space Regulation complements these provisions by specifying the documents the operator must submit as evidence of the fulfillment of the authorization conditions, which include the results of safety tests, emergency plans, and information on the collection and use of Earth observation data. Particular importance is attached to the mitigation of space debris. Operators are required to take measures in accordance with international space debris mitigation guidelines for the avoidance of operational debris, the prevention of on-orbit break-ups and collisions, and the removal of space objects from Earth orbit after the end of the mission. Another specificity of the Austrian space legislation is the possibility of an exemption from the insurance requirement or a reduction of the insurance sum, if the space activity is in the public interest. This allows support to space activities that serve science, research, and education. Moreover, the law also provides for the establishment of a national registry for objects launched into outer space by the competent Austrian Ministry. The first two Austrian satellites have been entered into this registry after their launch in 2012. The third Austrian satellite, launched in June 2017, will be the first satellite authorized under the Austrian space legislation.


text:
The Mountain Goats – "Damn These Vampires" (Stereogum Premiere)
When the Mountain Goats announced All Eternals Deck most folks focused on the fact that tr00 metal fan John Darnielle had death metal legend Erik Rutan (Morbid Angel, Hate Eternal) on hand to produce four of the 13 tracks. To the point that people assumed Darnielle was, in fact, planning to release a DM album. He debunked this quickly. Remember, just because you're recording with a death metal dude doesn't mean … etc. (Though this P4K interview with Darnielle's worth reading here, especially if you're curious how Rutan influenced certain sounds.) As mentioned previously, we also shouldn't overemphasize the Rutan thing because All Eternals was recorded in four different studios: Rutan did four songs, John Congleton handled four, Brandon Eggleston had one, and Scott Solter turned knobs for the rest. Unlike past Mountain Goats albums it's hard picking out a central theme (or overall feeling), but Darnielle's spoken about how "the songs cluster around themes of hidden things and the dread that hidden things inspire" and "the excitement, the attraction, the magnetic draw that scary unknown hidden things exert." He's said "other possible points of reference" include "'Burnt Offerings,' 'Go Ask Alice,' and that one scene in 'The Warriors' where they're on the train and the sun's coming up and they're safe but you know the scars are permanent now." We're also told the title All Eternals Deck refers to "an apocryphal tarot deck." It's fun excavating Darnielle's work, as always, and you might as well get started at the beginning with this opener, the Congleton-produced "Damn These Vampires," one that plays on this horror flick thing ("God damn these bite marks deep in my arteries…") as a classic Western. Or at least a story that can be told using genre imagery: "Brave young cowboys of the near north side / mount those bridge rails, ride all night / scream when captured: arch your back / let this whole town hear your knuckles crack…" This is a Mountain Goats album best experienced through headphones, so maybe don those.
The Mountain Goats – "Damn These Vampires"
All Eternals Deck:
01 "Damn These Vampires"
02 "Birth of Serpents"
03 "Estate Sale Sign"
04 "Age of Kings"
05 "The Autopsy Garland"
06 "Beautiful Gas Mask"
07 "High Hawk Season"
08 "Prowl Great Cain"
09 "Sourdoire Valley Song"
10 "Outer Scorpion Squadron"
11 "For Charles Bronson"
12 "Never Quite Free"
13 "Liza Forever Minnelli"
All Eternals Deck is out 3/29 via Merge. (The album doesn't include Twitter exclusive "Tyler Lambert's Grave," which you should download now.) Because the metal kids will be curious, Rutan produced "Birth Of Serpents" (of course), "The Autopsy Garland" (of course)," "Beautiful Gas Mask" (yes) and "Sourdoire Valley Song." The trio's heading out on tour with North Carolina BTW (and later Gayngs members) Megafaun, who're supporting on all dates except for 4/8 in Chapel Hill.
03/24 – Richmond, VA @ The National
03/25 – Washington DC @ 930 Club
03/26 – York, PA @ Strand-Capitol PAC
03/28 – New York, NY @ Bowery Ballroom
03/29 – New York, NY @ Bowery Ballroom
04/01 – Boston, MA @ Paradise
04/02 – Ithaca, NY @ Castaways
04/03 – Toronto, ON @ Opera House
04/05 – Chicago, IL @ The Vic
04/06 – Nashville, TN @ Mercy Lounge
04/07 – Atlanta GA @ Variety Playhouse
04/08 – Chapel Hill, NC @ Cat's Cradle
04/10 – Asheville, NC @ The Grey Eagle
04/11 – Columbus, OH @ Wexner Center
04/12 – Pittsburgh, PA @ Mr Smalls
04/15 – Philadelphia, PA @ Theater of Living Arts
Jon Wurster, Darnielle, and Peter Hughes out stargazing:


text:
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text:
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The global body for professional accountants
ACCA Canada receives many inquiries from ACCA members and student members worldwide who have an interest in working or studying in Canada. ACCA Canada is unable to directly assist individuals immigrating to Canada, and members and students are advised to contact the Canadian High Commission, embassy or consulate in their own country for details of immigration requirements.
Please visit http://www.cic.gc.ca/english/index.asp for the department of citizenship and immigration (CIC) in Canada.
Prospective permanent immigrants will need to meet the criteria of a points system which takes into account a number of factors such as education, qualifications, age and family currently in Canada. Details are available at the Citizenship and Immigration Canada website.
We can advise that ACCA members have received considerable education points on the basis of their ACCA qualification.
At the present, a member who holds an Association of Chartered Certified Accountants (ACCA) designation, is considered to hold a Bachelors degree.