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Boris EvelsonVice President & Principal Analyst
Boris serves the Application Development & Delivery role. He is a leading expert in business intelligence (BI) — a set of processes, methodologies, and technologies used to transform raw data into meaningful, useful, and action-oriented enterprise information. Boris… (Read Full Bio)delivers strategic guidance, helping enterprises define BI strategies, governance, and architectures and identify vendors and technologies that help them put information to use in business processes and end user experiences.Boris' current research focuses on the practical and actionable best practices for building BI infrastructure and applications, such as BI business cases, architectural options, organizational structures, and vendor selection. Boris continues to explore emerging trends in next-generation BI, such as agile BI architecture and development approaches, in-memory analytics, advanced data visualization, convergence of structured data and unstructured content analytics, process-driven and operational BI, and many others.Previous Work ExperienceBoris has more than 30 years of experience with enterprise software and applications implementation, management consulting, and strategic advisory skills. Most recently, Boris was a managing partner at Textra, a boutique strategic advisory firm serving all IT constituents: users, vendors, and investors. Boris cofounded Textra after spending several years as a VP and a strategic technology advisor at JPMorgan/LabMorgan, where he led many successful internal BI initiatives, advising the bank's large enterprise software clients on enterprise adoption issues and product and marketing strategies. Prior to JPMorgan, Boris served as a senior manager of data warehousing and customer relationship management (CRM) practices at PricewaterhouseCoopers. Boris started his career at Citibank, where, among many other successful projects, he implemented the bank's first global credit risk data warehouse.EducationBoris holds a degree in music education from Moscow Gnessin School Of Music, Russia.


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The Coelo Medium Siena coffee table is an elegant, stunning piece and the design is the key to the Coelo collection.
There are a range of palette colours available including soft neutrals such as Oyster white and Ice White, to contemporary colours like Harbour Grey, Toasted Almond and the stylish Natural Stone. You can also choose the palette colours with a Patina effect. The pieces are carefully painted then are rubbed and lightly distressed by hand with an aged patina so no two pieces are the same and individual for you. Please select a painted finish for the legs and a wood colour for the top. There really is a colour for everyone
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subset: commoncrawl


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Securio P36c Cross Cut
The Securio P36c Cross Cut shredder has precision engineering and aesthetic style. This shredder will take your worries away - and your breath, too. Ideal for entire departments and office floors.
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$29 a Month to Protect Kids From ID Theft?
By Alyssa Abkowitz
Axton Betz had just rented her first off-campus apartment in West Lafayette, Ind. when the power company told her she needed to pay a $100 deposit to turn on the electricity. Betz, who was 19 at the time, assumed they required the large deposit because she had no credit history. But, for safe measure, she requested a copy of her credit report. "I thought it would be just one page on student loans," Betz says. Instead, she found 10 pages of defaulted credit cards – showing someone had been using her identity since she was 11 years old.
Stealing social security numbers to buy cars, apply for credit and obtain driver's licenses has now shifted to a new demographic: those under the age of 18. Credit companies and other firms are responding offering monthly services promising identity-theft protection for children. According to the Federal Trade Commission, there is a market for this: 19,000 child identity theft complaints were reported in 2009, the most recent data available, up 217 percent since 2003. What's more, a study done by the Carnegie Mellon CyLab showed children are 51 times more likely to have their identity stolen than adults. And while most of these stolen IDs are used by undocumented immigrants or organized crime rings, there's also the chance a child's own parents could use their kid's digits, says Bo Holland, CEO of AllClear ID, an identity protection company.
Prompted by those numbers, on Monday Equifax launched a family plan that keeps tabs on the identities of two adults and up to four children. The service, which costs $29.95 a month, alerts parents by e-mail or text message whenever someone tries to use any of the family's IDs. It also scans the Internet for personal information found on websites and monitors the adults' files from the three credit bureaus. Earlier this month, AllClear ID debuted a free ID theft mobile app for the iPhone and iPad that lets a parent make sure her child's identity hasn't been compromised. (There's also an option for daily monitoring, which costs $14.95 a month.) And AllClear formed a partnership with the National Cyber-Forensics and Training Alliance to let consumers see the reports of stolen data that, before now, were only shared with companies.
To be sure, there are plenty of people, including child ID victims themselves, who aren't sure whether a paid service is worth the price. While the FTC received 19,000 complaints, there are more than 74 million Americans under the age of 18, according to the 2010 U.S. Census, putting the chances of child ID theft at a mere 0.02%. What's more, the FTC issued a report earlier this month raising concerns that when victims of ID theft called the credit bureaus, the agencies used those calls as an opportunity to sell ID theft protection products, instead of offering help. "Several respondents and focus group participants complained that they felt pressure to buy one or more products and that, in some cases, they received services that they did not want or need," according to the report. Equifax says dealing with possible fraud is the top priority, but "when appropriate, Equifax representatives also share information about our credit monitoring and identity theft protection products."
The credit companies contend the services are useful because children may be even more vulnerable to fraud than adults. That's because most children have blank slates and haven't yet used their social security numbers financially, making them much more valuable. At the same time, the theft can go undetected for quite some time – particularly if the pilfered identity is used for, say, an employment record, which doesn't pop up on a credit report. "It's scarier than having your car or wallet stolen because you can go years before knowing it's gone," says Trey Loughran, president of personal information solutions at Equifax. Indeed, Mercediz Hand, who's now 24, had her identity stolen when she was eight – and her social security number was used for an entire decade before she became aware of the fraud.
Even government entities are getting proactive; earlier this year Utah's attorney general teamed up with TransUnion to unveil a child protection program that allows parents to register their child's personal information on a state anti-theft website. And instead of assigning social security numbers that correspond to where and when a child was born – which makes theft much easier – the Social Security Administration now assigns randomized number series.
Still, for victims of child ID theft, any help is welcomed. Betz, now a doctoral student, spent years fixing her credit reports and still receives phone calls from collection agencies. One collection agency even tried to sue her, but the case was dismissed when she showed her birth certificate proving that she was 13 at the time, which alleviated her of any financial responsibility. Says Betz: "It's taken almost half my life to clear this up."


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DALLAS (AP) -- A model on the November cover of Teen Vogue is a 19-year-old who reveals in the magazine that she is pregnant.
Jourdan Dunn is not visibly pregnant on the cover, and Teen Vogue Editor-in-Chief Amy Astley said the magazine didn't know about Dunn's pregnancy until after the photo shoot. But she said that editors didn't consider pulling the cover Dunn shares with fellow model Chanel Iman.
"Teen pregnancy is a difficult, real-life issue that Teen Vogue readers (with an average age of 18) are mature enough to be exposed to," Astley said in a statement. "Teen Vogue felt it was important to support, not punish, Jourdan Dunn, who contributed to a beautiful photo shoot and who will surely have an ongoing and successful career in fashion."
The cover has raised eyebrows among some parents, teens and advocates against teen pregnancy.
"There's no message to send to them that that's not OK. Maybe if she's on the cover to tell them 'Be careful,' that's one thing," said Catherine Essig, a 19-year-old sophomore at Dallas' Southern Methodist University, who was concerned about 15- and 16-year-old readers.
Many advocates said parents should use the cover as a way to talk to their kids about sex and the importance of planning pregnancies for the right moment in their lives.
"Teen parenting isn't glamorous, even if you are a teen model," said Valerie Huber, executive director of the National Abstinence Education Association.
A message left by The Associated Press at Dunn's New York City agency was not immediately returned. The London native told Teen Vogue that her unplanned pregnancy has been hard.
"All I could think about was what my mom was going to say, my agency, my boyfriend," said Dunn, who is expecting a boy in December. "When I told my mom, she started crying and blaming herself. She got pregnant with me at the same age, and she said, 'I don't want you to have to go through what I did.'"
The magazine should be used as a teachable moment because the media and popular culture help shape "the social script for teenagers," said Bill Albert, a spokesman for the National Campaign to Prevent Teen and Unplanned Pregnancy.
"It shapes what they think is cool, is not cool, what's in, what's out, what's acceptable, what seems to be the social norm," he said. "It's not the only influence and I'd suggest not the most powerful, but it is an influence."
But parents, he said, shouldn't underestimate their own power.
"Young people tell us time and time again that parents -- not the media, not their partners, not their peers -- parents most influence their decisions about sex," he said.
After a record high in the early 1990s, the teen birth rate in the U.S. dropped 34 percent from 1991 to 2005. But between 2005 and 2007, it increased 5 percent, according to the National Campaign to Prevent Teen and Unplanned Pregnancy.
A lack of family planning remains a problem even as women get older -- 70 percent of pregnancies among 18 to 29-year-olds are unplanned, Albert said.
The magazine cover story mainly focuses on the two models' friendship, which grew chilly over competition for a time, and their experiences as black models in the fashion world.
Jill Taylor, chair of the women and gender studies department at Simmons College in Boston, said that she would have liked to have seen the magazine use the model's pregnancy to provide more information about teen pregnancy.
"Fourteen and 15-year-olds reading it don't have an idea how hard it is for most single mothers having babies. She's got resources," Taylor said.
That difference between Dunn and most teens could be a starting point for a discussion about timing.
"What do you want to have in place when you get pregnant?" asked Dr. Janet Realini, president of the Healthy Futures, a nonprofit dedicated to preventing teen and unplanned pregnancies in San Antonio and Texas. "For teens, we mostly want them to think about staying in school, finding the person who is right for them."
As a mother of four and a co-founder of a Plano-based faith-based group that advocates abstinence, 42-year-old Kim Hinkle said that while she might not like her teens to see a pregnant model on the cover of a magazine, she understands it's a topic that is pervasive in society.
She agreed with experts who said the article could start discussions.
"As a mother, it's hard because you've got to live in their reality," she said.
On the Net:
Teen Vogue: www.teenvogue.com


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The case
The AD national newspaper reported spilling of the compound with the name GenX in the environment and reaching drinking water. This was picked up by other newspapers, like de VK. The chemistry news outlet C2W commented on the latter on Twitter:
Translated, the tweet reports that we do not know if the compound is dangerous. Now, to me, there are then two things: first, any spilling should not happen (I know this is controversial, as people are more than happy to repeatedly pollute the environment, just because of self-interest and/or laziness); second, what do we know about the compound? In fact, what is GenX even? It certainly won't be "generation X", though we don't actually know the hazard of that either. (We have IUPAC names, but just like with the ACS disclosures, companies like to make up cryptic names.)
But having working on predictive toxicology and data integration projects around toxicology, and for just having a chemical interest, I started out searching what we know about this compound.
Of course, I need an open notebook for my science, but I tend to be sloppy and mix up blog posts like this, with source code repositories, and public repositories. For new chemicals, as you could read earlier this weekend, Wikidata is one of my favorites (see also doi:10.3897/rio.1.e7573). Using the same approach as for the disclosures, I checked if Wikidata had entries for the ammonium salt and the "active" ingredient FRD-903 (fairly, chemically they are different, and so may their hazard and risk profiles). Neither existed, so I added them using Bioclipse and QuickStatements (a wonderful tool by Magnus Manke): GenX and FRD-903. So, a seed of knowledge was planted.
A side topic... if you have not looked at hypothes.is yet, please do. It allows you to annotate (yes, there are more tools that allow that, but I like this one), which I have done for the VK article:
I had a look around on the web for information, and there is not a lot. A Wikidata page with further identifiers then helps tracking your steps. Antony Williams, previous of ChemSpider fame, now working on the EPA CompTox Dashboard, added the DTX substance IDs, but the entries in the dashboard will not show up for another bit of time. For FRD-903 I found growth inhibition data in ChEMBL.
But Nina Jeliazkova pointed me to her LRI AMBIT database (poster abstract doi:10.1016/j.toxlet.2016.06.1469, PDF links) that makes (public) data from ECHA available from REACH dossiers in a machine readable way (see this ECHA press release), using their AMBIT software (doi:10.1186/1758-2946-3-18). (BTW, this makes the legal hassle Hartung had last year even more interesting, see doi:10.1038/nature.2016.19365). After creation of a free login, you can find a full (public) dossier with information about the toxicology of the compound (toxicity, ecotoxicity, environmental fate, and more):
I reported this slide, as they worry seems to be about drinking water, so, oral toxicity seems appropriate (note, this is only acute toxicity). The LD50 is the median lethal dose, but is only measured for mouse and rat (these are models for human toxicity, but only models, as humans are just not rats; well, not literally, anyway). Also, >1 gram per kilogram body weight ("kg bw"; assumption) seems pretty high. In my naive understand, the rat may be the canary in the coal mine. But let me refrain from making any conclusions. I leave that to the experts on risk management!
Experts like those from the Dutch RIVM, which wrote up this report. One of the information they say is missing is that of biodistribution: "waar het zich ophoopt", or in English, where the compound accumulates.


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BOSTON - Commercial health club financial performance improved for the quarter ending March 31, 2006, compared to the same period last year, according to a recently conducted survey of 26 North American health and sports club companies. The 26 small to mid-size clubs represent 175 facilities or an average of seven clubs per company. The survey was conducted for the International Health, Racquet & Sportsclub Association (IHRSA) by Industry Insights Inc.
The IHRSA index found that on a per club basis, a club grew its revenue an average of 3.8 percent to $1.2 million in revenue per club for the quarter. The participating companies also reported improved same-store revenue for clubs that have been in operation for at least two years, by an average of 5.1 percent to $1.2 million.
"The commercial health club industry typically shows growth during the first quarter, as Americans begin their new year's resolutions and make a commitment to get fit," said Joe Moore, president and CEO of IHRSA. "However, the results from this quarter indicate that even with a low to moderate rate of growth in total number of members, there was a highly respectable rate of growth in non-dues revenues. Clubs are realizing the importance of retaining their current members and offering them more quality cost oriented services."
A 10.6 percent increase in the club's same-store non-dues revenue is a testament to clubs successfully offering more at cost services. However, the IHRSA index found that the average earnings before interest, taxes, depreciation, amortization and rent (EBITDAR) increased by a moderate 1.5 percent to $0.25 million per club. As a percentage of revenue, EBITDAR was 21.1 percent of revenue for the first quarter of 2006 and 21.6 percent of revenue in 2005.


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DELHI, INDIA (Sept. 12, 11:45 a.m. ET) — The Delhi government is set to prohibit the production, storage and use of plastic bags in India's capital. The ban will also apply to some packaging applications including clear sleeves for greeting cards.
"Any kind of plastic will be banned now, whether it is thin or thick. However, the ban has not been imposed on woven plastics," said Delhi chief minister Sheila Dikshit. "Plastic bags choke drains and spoil the environment," she added.
Official documentation setting out the scope of the ban states: "No person, including a shopkeeper, vendor, wholesaler, retailer, trader and hawker, shall sell or store or use any kind of plastic carry bag for storing or dispensing eatables or non-eatable goods or materials."
The ban won't, however, apply to any plastic bag applications covered by the Bio-Medical Waste Management and Handling Rules, 1998.


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Now You're Thinking With Mari0rtals
My admirable, handsome, humble, delightful paymaster Mr. Walker already mentioned the remarkable looking Mari0 in October, but it wasn't out then. Truth be told, it's not quite out yet – but at about 10 tomorrow evening, this amazing mash-up of Super Mario and Portal 2 will downloadable. I point out it's Portal 2 to make a clear distinction: it has the gel and it will eventually have online co-op (currently it has local) in addition to the Portal gun. It also has Super Mario Bros, but let's not hold that against it. Even more moving imagery of it exists through this portal. Come… 0
Via Reddit.


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ifm's control systems can be completely operated via the program.
The connection is established via a standardised serial interface or a CAN PC interface.
The software allows setting of all communication parameters of the connected controller, programming of the controller in a PLC programming language standard and diagnosis/visualisation of the available data in the controller.


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In Virginia, Judge James Michael Shull was faced with of two divorced parents, each wanting custody of their child for Christmas. Since there was no compelling reason to choose one parent over the other, Judge Shull tossed a coin. The Virginia Supreme Court ruled last week that Judge Shull "failed to uphold the dignity of the judiciary," and removed him from the bench: a rather draconian punishment, given the behavior of some judges who are allowed to keep their gavels and robes (such as Philadelphia judge Teresa Carr Deni, appointed to another 6-year term earlier this month, despite her decision last month to downgrade the alleged at-gunpoint rape of a prostitute to a "theft of services" charge).
And exactly how should Judge Shull have resolved this issue? This was the proverbial coin-toss decision, which made tossing a coin rather appropriate. Would the Virginia Supreme Court have preferred he ask for a sword and suggest a more Solomonic solution?
- No Charges For 10-Year-Old Firestarter and other crime news both serious and not


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Pinto, John (jp904)Skip to content Skip to main navigation
532B Thndk
Educational Background
Ph.D., (Biochemistry), University of Medicine and Dentistry of NJ, 1974
Post-doctoral studies (Nutrition), Columbia University, 1975-78
Scholarly Interests
Selected Publications
CHAPTERS IN BOOKS: 2013 (Life time chapters published 14)
Pinto JT and Rivlin RS. Riboflavin. IN: Handbook of the Vitamins. Nutritional, Biochemical, and Clinical Aspects. Gregory J, Stover P, Suttie JW and Zempleni J., eds. (New York, Taylor and Francis, Inc., Fifth Edition), 2013.
Aquilato A, Lopez V, Doonan B, Hsieh T-C, Pinto JT, Wu E and Wu JM. BRAF Mutation in Melanoma and Dietary Polyphenols as Adjunctive Treatment Strategy. Chapter 102. IN: Polyphenols in Human Health and Disease: Vol 2; Watson RR, Preedy VR, and Zibadi S. eds. (Elsevier: San Diego, CA,) 2013.Cooper AJL, Dorai T, Dorai B, Krasnikov BF, Li JY, Hallen A, and Pinto JT. Role of glutamine transaminases in nitrogen, sulfur, selenium and 1-carbon metabolism: Glutamine Transaminases in normal and cancer Cells. IN: Glutamine in Health and Disease. Rajendram R, Preedy VR, and Patel VB. (Eds.) (Springer, New York) 2013.
JOURNAL ARTICLES PUBLISHED IN 2010-2014 (Life time publication 117 peer-reviewed manuscripts)
Cooper AJL, Krasnikov BF, Pinto JT, Bruschi SA. Measurement of cysteine S-conjugate β-lyase activity. Current Protocols Toxicol., 44: Chapter 4: Unit 4.36.1-16, 2010.
Cooper AJL, Krasnikov BF, Niatsetskaya ZV, Pinto JT, Callery PS, Villa MT, Artigues A, Bruschi SA. Cysteine S-conjugate β-lyases: Important roles in the metabolism of naturally occurring sulfur-and selenium-containing compounds, xenobiotics and anticancer agents. Amino Acids 41(1): 7-27, 2011.
Pinto JT, Lee J-I, Sinha R, MacEwan M., Cooper AJL. Chemopreventive mechanisms of α- keto acid metabolites of naturally occurring organoselenium compounds. Amino Acids 41(1): 29-41, 2011.
Chua CO, Vinukonda G, Hu F, Labinskyy N, Zia MT, Pinto J, Csiszar A, Ungvari Z , Ballabh P. Effect of Hyperoxic Resuscitation on Propensity of Germinal Matrix Hemorrhage and Cerebral Injury. Neuropathol Appl Neurobiol 36(5): 448-458, 2010.
Facompre N., El-Bayoumy K, Sun Y-W, Pinto J, Sinha R. 1,4-phenylenebis(methylene)-selenocyanate (p-XSC) but not selenomethionine inhibits multiple signaling pathways in human prostate cancer cells. Cancer Prev Res 3(8): 975-984, 2010.
Ungvari Z, Gautam T, Koncz P, Henthorn JC, Pinto JT, Ballabh P, Yan H, Mitschelen M, Farley J, Sonntag WE, Csiszar A. Vasoprotective effects of lifespan-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci 65(11): 1145-1156, 2010.
Ungvari Z, Bailey-Downs L, Gautam T, Sosnowska D, Wang M, Monticone RE, Telljohann R, Pinto JT, de Cabo R, William E. Sonntag WE, Lakatta E, Csiszar A. Age-associated vascular oxidative stress, Nrf2 dysfunction and NF-kB activation in the non-human primate Macaca mulatta. J Gerontol A Biol Sci Med Sci 66(8): 866-875, 2011.
Cooper AJL, Pinto JT, Callery PS. Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol 7(7): 891-910, 2011. Review. Erratum in: Expert Opin Drug Metab Toxicol 7(9): 1183, 2011.
Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappillya JB, Speer RE, Ahn Y-H, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG. Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chem Biol 18(6): 752-765, 2011.
Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarce N, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: A novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 67(4): 313-329, 2012.
Sinha I, Null K, Wolter W, Suckow MA, King T, Pinto JT and Sinha R. Methylseleninic acid down regulates hypoxia inducible growth factor-1a in invasive prostate cancer. Int J Cancer. 130(6): 1430-1439, 2012.
Bridges CC, Krasnikov BF, Joshee L, Pinto JT, Hallen A, Li J, Zalups RK, Cooper AJL. New insights into the metabolism of organomercury compounds: Mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine g-lyase. Arch Biochem Biophys 517(1): 20-29, 2012.
Facompre ND, El-Bayoumy K, Sun Y-W, Pinto JT and Sinha R. Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene) selenocyanate in human prostate cancer cells. Int J Cancer. 131(9):2134-42, 2012.
Csiszar A, Podlutsky AJ, Podlutskaya N, Sonntag WE, Merlin SZ, Philipp EER, Doyle K, Davila A, Recchia FA, Ballabh P, Pinto JT, Ungvari Z. Testing the oxidative stress hypothesis of aging in primate fibroblasts: Is there a correlation between species longevity and cellular ROS production? Gerontol A Biol Sci Med Sci 67(8): 841-852, 2012.
Cooper AJL, Krasnikov BF, Pinto JT, Kung HF, Li J-Y Ploessl K. Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. Comp Biochem Physiol B Biochem Mol Biol 163: 108-120, 2012.
Khomenko T, Kolodney J, Pinto JT, McLaren GD, Deng X, Chen L, Tolstanova G, Paunovic B, Krasnikov BF, Hoa N, Cooper AJL, Szabo S. New mechanistic explanation for the localization of ulcers in the rat duodenum: Role of iron and selective uptake of cysteamine. Arch Biochem Biophys 525: 60-70, 2012.
Tsikas D, Evans CE, Denton TT, Mitschke A, Gutzki FM, Pinto JT, Khomenko T, Szado S, Cooper AJL. Stable-isotope GC-MS/MS determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples. Anal Biochem. 430(1):4-15, 2012.
Pinto JT, Cooper AJL. From cholesterogenesis to steroidogenesis: Role of riboflavin and flavoenzymes in the biosynthesis of vitamin D. Adv. Nutr. 5: 1–20, 2014.
Sinha I, Allen J, Pinto JT, and Sinha R. Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia. Int J Cancer: 2014
a. Naturally-occurring organoselenium compounds
Our laboratory has identified mechanisms whereby naturally occurring organoselenium compounds exhibit chemopreventive effects on prostate and colon cancers. We discovered novel metabolic conversions of diet-derived selenoamino acids, Se-methyl-L-selenocysteine (MSC) and L-selenomethionine (SM), to their respective selenoketo acid metabolites, methylselenopyruvate (MSP) and ketomethylselenobutyrate (KMSB). Metabolism of MSC and SM and hence their chemopreventive qualities, were previously thought to occur primarily through β- and γ-lyase reactions. The lyase pathways were hypothesized to generate highly reactive and short-lived, methylselenol, a metabolite that has not been measured nor identified to exist within tissues. Our work shows that the selenoketo acids, derived from MSC and SM, but not MSC and SM themselves, exhibit potent inhibitory effects on a variety of histone deacetylases. This information has significantly altered our basic understanding of the chemopreventive activity associated with diet-derived organoselenium compounds. We have also identified the specific transaminases responsible for the transamination of selenoamino acids to their corresponding keto acids as well as the selectivity of the tissue types capable transamination of each selenoamino acid. Accordingly, glutamine transaminase K (kidney, GTK) selectively converts MSC to MSP and has less than 0.1% the activity with SM. GTK is a ubiquitous enzyme and displays varying degrees of activity in various tissues. By contrast, glutamine transaminase L (Liver, GTL) selectively metabolizes SM to KMSB exhibiting much less activity toward MSC (5-10% that observed with SM). This enzyme is present in liver and is marginally found in other tissues such as pancreas. The significance of this information resides in issues surrounding the aborted nation-wide, clinical study SELECT. Androgen responsive and non-responsive prostate cancer cells do not possess GTL but rather GTK and thus SM, which was provided to SELECT volunteers, was NOT effective in prostate cancer prevention perhaps for these reasons. By contrast, prostate cells do exhibit adequate activity of GTK and thus would have exhibited a response if methylselenocysteine had been used. This remains a viable issue and, in this investigator's opinion, should evoke further studies.
In both human prostate and colon cancer cells in culture, acetylated histone H3 levels increase during the period 5-24 h after treatment with direct addition of the selenoketo acids (MSP or KMSB). The proportion of cells occupying G2/M phase of the cell cycle increases at 10-50 µM MSP and KMSB, and apoptosis is induced, as evidenced by morphological changes, Annexin V staining, and increased cleaved caspase-3, -6, -7-, -9, and poly(ADP-ribose)polymerase. P21WAF1, a target used by investigators studying clinically-approved HDAC inhibitors, increases in MSP- and KMSB-treated colon cancer cells. Thus, in addition to targeting redox-sensitive signaling factors, selenoketo acids inhibit HDAC activity and nuclear status of acetylated histones.
b. Organoselenium compounds
In additional investigations on organoselenium compounds, we showed that another potential metabolite of methylselenocysteine promotes apoptosis in invasive prostate cancer cells in part by down regulating hypoxia inducible factor-1α (HIF-1α). Accordingly, we demonstrate that methylseleninic acid activates or stabilizes REDD1 (Regulated in Development and DNA Damage Response 1), a conserved mitochondrial stress-response protein whose over-expression inhibits the mTOR (mammalian target of rapamycin) pathway, a critical regulator of tumor cell proliferation. REDD1 has been suggested to act by binding to and sequestering 14-3-3 proteins away from tumor suppressor TSC2 (tuberous sclerosis complex subunit 2) thus leading to TSC2-dependent inhibition of the mTOR pathway. Endogenous REDD1 is required for both dissociation of endogenous TSC2/14-3-3 and inhibition of mTORC1 in response to HIF-1α and hypoxia. Thus, methylseleninic acid activates REDD1 in metastatic prostate cancer cells and significantly inhibits expression of factors that activate the PI3K/PKB and mTOR/p70S6K1 signaling pathways even under hypoxic conditions. In brief, phosphatidylinositol-3-kinase (PI3K) transmits a mitogenic signal through protein kinase B and mammalian target of rapamycin (mTOR) to p70S6K1. The mTOR inhibitor, rapamycin, is recognized to inhibit cells in G1 cell cycle progression and to block expression of cyclin D1, CDK4, CDC25A, and retinoblastoma phosphorylation. Our data suggest that methylseleninic induces REDD1 and inhibits prostate cancer cell growth in hypoxia despite activation of PKB and dysregulation of mTOR which are viable therapeutic targets in control of prostate cancer pathologies.
c. Naturally-occurring organosulfur compounds
Our studies show that S-allylmercaptocysteine (SAMC), a garlic-derived compound, inhibits growth, arrests cells in G2/M, and induces apoptosis in LNCaP, LNCaP C4-2, and PC-3 human prostate carcinoma cells as well as in SW480 and HT29 human colon cancer cells. Indirect immunofluorescent staining for microtubules (MTs) reveal that treatment of colon cancer cells or NIH3T3 fibroblasts with varying doses of SAMC causes MT depolymerization and MT cytoskeleton disruption in interphase cells, and interferes with the spindle assembly in mitotic cells.
Our investigations of signaling pathways involved in SAMC-induced apoptosis found that SAMC causes rapid and sustained induction of c-Jun NH2-terminal kinase-1 (JNK1) activity. SAMC also activates caspase-3, as evidenced by the cleavage of a fluorogenic tetrapeptide substrate and of poly(ADP-ribose) polymerase. Conclusions thus far are that garlic-derived SAMC exerts anti-proliferative effects, at least in part, by disrupting MT assembly thus arresting cells in mitosis and triggering JNK1 and caspase-3 signaling pathways that lead to apoptosis. By investigating the regulatory role displayed by garlic-derived allylsulfides on expression of inducible redox sensitive signal proteins and enzymes and on the overall antioxidant potential of the cell, our studies summarize newly identified mechanisms by which garlic-derived allylsulfide constituents may contribute significantly to cancer prevention and control.
These studies provide novel paradigms by which diet-derived organoselenium and organosulfur compounds might protect against prostate, colon, and a variety of other cancers.


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ISSUES BEYOND PALO ALTONeighborhoods
Read the full story here http://www.PaloAltoOnline.com/news/show_story.php?id=10982 posted Tuesday, January 27, 2009, 11:30...Original post made on Feb. 22, 2009
Last comment by tracey Chen, on Jun 25, 2009 at 1:21 pm | 3 comments | 1240745 Views
SCHOOLS & KIDSWhat gives the school the right to give my child homework?
This is a legitimate question. I called the California Department of Education today and they did not know the answer. What...Original post made by Parent on Dec. 18, 2014
Last comment by Overload, on Aug 5, 2016 at 9:05 am | 481 comments | 657610 Views
SCHOOLS & KIDSStudent with 3.85 GPA gets rejection letters from UCs
Hi, My friend's daughter got 3.85 GPA, had 5 AP classes in high school, was on competitive swimming team, volunteered...Original post made by Parent on May. 28, 2012
Last comment by Nayeli, on Jun 28, 2017 at 7:48 pm | 373 comments | 581274 Views
ISSUES BEYOND PALO ALTOEnjoying multi-tasking?
0...Original post made by Mr. Man on Mar. 26, 2007
Last comment by Mimi Butternut, on Mar 29, 2007 at 1:34 am | 2 comments | 541832 Views
PALO ALTO ISSUESNikola Tesla statue to be unveiled in Palo Alto
A statue of the inventor of Nikola Tesla -- equipped with free Wi-Fi and a time capsule to be opened in 2043 -- is set to...Original post made on Dec. 6, 2013
Last comment by ACDC, on Jun 14, 2017 at 1:03 pm | 46 comments | 471624 Views
SCHOOLS & KIDSPaly school board rep: 'The sorrows of young Palo Altans'
My stress began in elementary school, where students were segregated into separate class meetings as "early" and "late" readers,...Original post made on Mar. 25, 2015
Last comment by BalancedParent, on Mar 30, 2017 at 3:54 pm | 487 comments | 365982 Views
AROUND TOWNThe things I remember about Palo Alto while growing up:
0...Original post made by Andrew L. Freedman on Oct. 19, 2006
Last comment by Steve L, on Sep 8, 2020 at 5:52 am | 1199 comments | 363411 Views
PALO ALTO ISSUESDowntown development sparks architecture debate
With its glassy walls, boxy shape, 50-foot height and preponderance of office space, a four-story building proposed for 240...Original post made on Sep. 5, 2013
Last comment by bru, on Sep 14, 2013 at 5:36 pm | 51 comments | 357005 Views
SCHOOLS & KIDSParents: Keep calm and parent on
I am a psychiatrist. After the tragedy last week, my phone has not stopped ringing with calls from concerned fellow parents....Original post made on Mar. 16, 2015
Last comment by But, but, but..., on Mar 21, 2016 at 5:31 pm | 215 comments | 354797 Views
PALO ALTO ISSUESHitting the restart button
Inside Palo Alto's newly renovated Downtown Library recently, Cornelia van Aken rattled off a list of new programs the staff...Original post made on Jul. 8, 2011
Last comment by KC, on Jul 19, 2011 at 3:23 pm | 14 comments | 348188 Views
PALO ALTO ISSUESBarron Park survey shows strong support for referendum on Maybell development
A grassroots effort to reverse City Council's approval of a controversial development on Maybell Avenue is quickly gathering...Original post made on Jul. 3, 2013
Last comment by Resident, on Jul 12, 2013 at 11:59 am | 61 comments | 346913 Views
CRIMES & INCIDENTSStanford sex-assault victim: 'You took away my worth'
Standing in front of a full courtroom in Palo Alto on Thursday, the 23-year-old college graduate who was sexually assaulted...Original post made on Jun. 3, 2016
Last comment by @Vince, on Jun 5, 2016 at 2:24 pm | 65 comments | 345627 Views
PALO ALTO ISSUESPalo Alto highest in county for disability claims by police, firefighter retirees
More than half of Palo Alto's police officers and firefighters retired with disability benefits over the past five years,...Original post made on Jun. 28, 2013
Last comment by S. Coen, on Jul 13, 2013 at 8:51 am | 76 comments | 288867 Views
SCHOOLS & KIDSSchool documents and source materials
In addition to documents and other original source material linked within news stories, other material obtained from the...Original post made on Nov. 24, 2013
There are no comments yet. 281054 Views
CRIMES & INCIDENTSSAP Palo Alto vice president arrested for LEGO scam
The vice president of Palo Alto software firm SAP Labs, LLC will be charged on Tuesday with four felony burglary charges...Original post made on May. 21, 2012
Last comment by sea reddy, on Jun 27, 2015 at 6:55 am | 40 comments | 279012 Views
PALO ALTO ISSUESJust how high can rent be increased?!?
I have been a great tenant for almost 16 years. The landlord (now in property management) is not the greatest, & maintenance...Original post made by mmmmMom on Jan. 30, 2013
Last comment by John, on May 27, 2013 at 5:43 pm | 40 comments | 277641 Views
AROUND TOWNMove Your Car Or Be Towed!
0...Original post made by Resident on Jun. 24, 2008
Last comment by follow the rules , on Apr 25, 2017 at 1:38 am | 71 comments | 268013 Views
PALO ALTO ISSUESCameras for running red lights in PA?
Too many people are running red lights when the signal is CLEARLY already read. Not just turning from yellow to red. I live...Original post made by Pro-Big Brother on Nov. 24, 2009
Last comment by jb, on Dec 9, 2009 at 3:11 pm | 68 comments | 266177 Views
AROUND TOWNPark Blvd crash spurs $17 million claim with Palo Alto
The family of a 12-year-old boy who was struck by a vehicle while riding on the 2500 block of Park Boulevard has filed a...Original post made on Jul. 2, 2013
Last comment by CrescentParkAnon., on Jul 8, 2013 at 10:54 am | 60 comments | 260648 Views
AROUND TOWNWilbur Junior High
0...Original post made by Andrew L. Freedman on Mar. 3, 2008
Last comment by Mark Baugh, on Aug 3, 2016 at 2:53 pm | 44 comments | 260421 Views
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For the last 26 years, the Palo Alto Weekly Holiday Fund has given away more than $7 million to local nonprofits serving children and families. When you make a donation, every dollar is automatically doubled, and 100% of the funds go directly to local programs. It's a great way to ensure your charitable donations are working at home.


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2003 Facilities Standards (P100) Overview
The Facilities Standards for the Public Buildings Service establishes design standards and criteria for new buildings, major and minor alterations, and work in historic structures for the Public Buildings Service (PBS) of the General Services Administration (GSA). This document contains policy and technical criteria to be used in the programming, design, and documentation of GSA buildings.
The Facilities Standards is a building standard: it is not a guideline, textbook, handbook, training manual or substitute for the technical competence expected of a design or construction professional.
A hardcopy of the Facilities Standards for the Public Buildings Service is available for purchase from the Government Printing Office.


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Back from break, Rangers still struggle with men on
O's rob homer from Beltre as Texas leaves 10 stranded in Holland's loss
ARLINGTON -- The Rangers were 0-for-10 with runners in scoring position and Adrian Beltre had a home run taken away from him by right-fielder Nick Markakis. Jeff Baker had a brilliant baserunning play that led to one run, but was also thrown out on the bases at a crucial time to cost the Rangers another run.
The Rangers did not get off to a great start offensively when the second half began Friday night and they lost to the Orioles, 3-1, at the Ballpark in Arlington. A couple of missed defensive plays also cost the Rangers one run on their way to a fifth loss in six games dating back before the All-Star break.
"We were so close," shortstop Elvis Andrus said. "You're that close and you're not able to execute, for sure you get mad. But the only way to win is by creating opportunities. Sooner or later, you're going to get the key hit."
The Rangers are still waiting to get the key hit after getting a runner on base in eight of nine innings. They also had a runner in scoring position in six of nine innings, but scored only one run against Orioles starter Wei-Yin Chen and relievers Darren O'Day and Jim Johnson.
"We just couldn't get the hit with runners in scoring position," catcher A.J. Pierzynski said. "It was one of those nights where we got guys out there, but we couldn't get them in. That's frustrating, but those things happen."
The Rangers are 4-for-37 with runners in scoring position in their last six games. They were hitless in four of those games and 19 overall with runners in scoring position this season. They are 2-17 in those games.
"Whatever it is, we didn't get it done," Beltre said.
Chen ended up getting the win and has won two straight starts over the Rangers since coming off the disabled list. He is 3-0 with a 1.29 ERA in three career outings against them.
Derek Holland pitched just as good as Chen and still took the loss after allowing three runs on just six hits in eight innings. But he gave up a home run to Matt Wieters in the second and, after a leadoff walk, an RBI double to Nate McLouth in the third to fall behind, 2-0.
The Rangers picked up a run in the fourth, only after Beltre hit a deep fly ball that was headed for a home run before Markakis snatched it, clearly extended over the right-field wall.
Baker then singled and demonstrated some heads-up baserunning. Mitch Moreland, with the infield shifted severely toward the right side, drew a walk. Baker jogged to second on the fourth ball, then noticed Orioles third baseman Manny Machado late getting back to his normal position. Baker bolted for third and made it easily. He scored on Craig Gentry's sacrifice fly.
"Machado had his head down and wasn't getting back to third base with any urgency," Baker said. "As soon as I saw him put his head down, I just went and was able to get in there pretty easy."
But then things got frustrating for the Rangers. Holland retired the first two batters in the fifth before Machado reached base on an infield hit -- a grounder up the middle that second baseman Ian Kinsler scooped up behind the bag, but bounced a throw to first that Moreland couldn't handle.
Markakis followed with a high pop to left-center. Gentry, starting in center, came in and missed a diving catch, and left fielder Jurickson Profar overran the ball while backing up. It got behind him and Machado came all the way around to score.
"I'm not really sure. [Profar] was playing a little farther over than I thought," Gentry said. "The ball was in between and I couldn't get there."
Said Profar, "(Gentry) dove and almost caught it, so I couldn't see the ball if he caught it or not."
Kinsler led off the fifth with a double and the Rangers couldn't get him home. Andrus moved him to third with a grounder to the right side. But Chen retired Pierzynski on a grounder back to the mound and Beltre on a grounder to third to end the inning.
In the sixth, Baker led off with a single. After Moreland struck out, Gentry doubled into right-center. Baker raced around third, but was held up at the last second by third-base coach Gary Pettis. Center fielder Adam Jones overthrew the cutoff man, but shortstop J.J. Hardy was right behind him. He corralled the throw, then caught Baker too far off third base and fired over for the out.
"I'm going pretty hard," Baker said. I'm running hard the whole way. I pick him up right before I hit the bag. I see him waving me, so I hit the bag and then he put the stop sign. I tried to get back the best I could, and they had me."
It was that kind of game for the Rangers on the first night of the second half.


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A team of designers have a taken one of the worlds most pressing environmental issues and created a piece which speaks louder than words. Designers Ricardo Casas, Alejandro Castro, Héctor Esrawe, Emiliano Godoy and Cecilia León de la Barra have produced a thought provoking rug, which contrasts it's oft and pleasant texture with the prickly problem we have surrounding the rapid decline of the Polar bear and melting ice caps.
Ironically named " Global Warming", this statement piece is sure to make anyone stop and think whether its placed in a living room, waiting room or café. I'm very impressed with the rugs simple design and how it conveys this message with such impact.
I would definitely have one of these in my home as way of raising awareness of global warming.


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After Sprint's MiFi 2200 mobile router and T-Mobile's 4G Mobile Hotspot ZTE MF61, the Samsung 4G LTE Mobile Hotspot SCH-LC11 from Verizon is the third mobile router we've reviewed.
While these mobile routers share a few major features such as support for both 4G and 3G networks, and the limit of just five concurrent wireless clients, each has its own pros and cons. In the case of the Samsung 4G LTE Mobile Hotspot SCH-LC11, the main difference is where it matters the most: the Internet connection. It's by far the fastest of the three. On the downside, the Samsung also lacks many features found in the others.
The router's incredibly speedy Internet connection, unfortunately, is counterbalanced by the expense of the two data plans, which have monthly caps of 10GB and 5GB for a cost of $80 and $50, respectively. The router itself costs $100 with a two-year contract.
If you're a business user who needs a fast Internet connection on the go but doesn't do a lot of downloading, or you just don't care about the extra costs incurred when the caps are reached, Verizon's Samsung 4G LTE Mobile Hotspot SCH-LC11 makes the most satisfying mobile router among its peers. For those who are on a budget, however, we'd recommend alternatives from Sprint or T-Mobile.
Measuring 3.5 inches by 2.3 inches by 0.5 inch, Verizon's Samsung 4G LTE Mobile Hotspot SCH-LC11 is about the same size as Sprint's MiFi 4082 3G/4G Mobile Hotspot. It's compact and good-looking enough to be tucked away or show off on the desk.
On top, the Samsung has a large on/off button that you need to press and hold for a few seconds for it to take effect. Next to it is an array of tiny LCDs that show the status of the Wi-Fi network and the cellular network the device is connected to, be it a 4G or a 3G. The router doesn't have a Wi-Fi Protected Setup (WPS) button to support quick additions of wireless clients to the network. This means the only way to connect a client is to enter the encryption key manually. Another thing that users will miss is the lack of a battery gauge. In order to see how much juice left in the battery, you'll have to log in to the router's Web interface, which is a hassle and might not even be possible via a mobile device.
On one side the router has a standard Micro-USB port for charging that has a nifty cover to keep it from getting dusty. Unlike Sprint's MiFi 4082, this port doesn't support tethering, meaning that when it's connected to a computer, the computer won't gain Internet access via the router. This limits the use of the router to Wi-Fi clients only.
Out of the box, the router is set up with an SSID (Wi-Fi network name) and the encryption key, both printed on a label underneath the bottom cap that covers the removable battery. This means all you have to do is insert the SIM into its slot, which is under the battery, turn it on, and get wireless devices connected to this default network, and you're up and running. There's no setup required.
If you want to further customize the device, you can do that by going to its Web interface. From a connected computer, point a browser to the router's default IP address, which is 192.168.1.1.
Verizon's Samsung 4G LTE Mobile Hotspot SCH-LC11 has the least amount of features among the three 4G mobile routers we've reviewed. It doesn't support network storage, lacks WPS, and has no built-in GPS. It doesn't have a port for an external antenna, either.


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Be a part of a unique online community that connects post production professionals and film academics worldwide.
You'll have access to personalize your news feed, access to Live Post Talks and much more. Contribute to the community by posting interesting post production content.
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For The Drew Barrymore Show, a set-up established by CBS VFX allows Barrymore to appear on a dynamic set in New York City while her guests appear in real-time from a secure set in Los Angeles. You can see the set-up below, and check out a clip of the show for how the final product looks.
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Foundry has released Nuke Indie 12.2v3, the latest version of its $499/year edition of the compositing software aimed at freelancers and artists starting up in business for themselves.
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If you're looking to showcase your video work in style, then check out our top three templates for Premiere Pro to help you create a showreel or demo reel.
September 25, 2020, 1:32 pm
Sound Devices just released a major firmware update for the 8-series mixer/recorder. Besides a long list of improvements and additions, the most notable new feature is SuperSlot support for the Wisycom MCR54 wireless receiver and compressors on all busses. The SD-Remote App also got a v7.00 update with additional features.
September 25, 2020, 1:32 pm
It's commonly noted that for many aspects of art, there are no rules. While you could say the same for editing, there's still a set of practical and theoretical practices that will improve your videos. Today let's look at the practical side and divide your edit into specific stages to maintain an efficient workflow.
September 25, 2020, 1:32 pm
As of Monday, "The Eight Hundred" became the highest-grossing movie of 2020 at the global box office, overtaking "Bad Boys for Life." To date, the Chinese war epic has raked in $425 million and continues to exceed all expectations.
September 25, 2020, 1:31 pm
Back in July, AWN reported that leading media and entertainment creative software company Foundry released Nuke Indie, an accessible version of Nuke Studio for eligible solo artists. Nuke Indie was the latest addition to the Nuke family of products combing industry-leading node-based compositing toolset of NukeX with the conform, editorial and review capabilities in Nuke Studio, making it a powerful and important tool for artists wanting to create high-quality visual effects.
September 25, 2020, 1:31 pm
VFX Legion has announced that CG supervisor, Blake Anderson, has joined the recently launched B.C. division's leadership team; the industry veteran brings a range of skills and experience managing and collaborating with large work-from-home teams of artists on feature films and episodic series. The announcement was made by company founder, James David Hattin.
September 24, 2020, 4:52 pm
Don't miss this VFX Breakdown by Pixomondo about their work on the impressive World War 1 sequence and many more for PERRY MASON...
September 24, 2020, 4:52 pm
In 2013, Jeff Campbell explained the work of Spin VFX on AFTER EARTH. He then worked on many shows including GAME OF THRONES, JOHN WICK, FEAR THE WALKING DEAD and THE SHANNARA CHRONICLES.
Gordon sits down with cinematographer James Kniest to discuss his work on The Haunting of Bly Manor. Including hiding people ...
Gordon sits down with documentary editor and producer Kathryn Robson to discuss storytelling and her work on the hit Netflix ...
Gordon sits down to talk to Emmy Nominated editors Kate Sanford & Tim Streeto to discuss their work on the Marvelous Mrs. ...
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Primary Health Care (PHC) Indicators Chartbook: An Illustrative Example of Using PHC Data for Indicator Reporting (PDF)
This 2008 chartbook offers an illustrative example of how primary health care information can be used to populate indicators on access, recommended care and organization/service delivery.
A review of seminal national and international health care research as it maps to health care priorities.
This analytical report measures the risk of a wide range of adverse events in Canadian health care delivery.
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Caramel Corn
Crunchy, buttery, and sweet.
This easy treat—popcorn slathered with buttery caramel—had the CHOW staffers lurking around the test kitchen awaiting the next batch. The caramel corn will last up to a week, making it the perfect gift to package and mail during the holidays.... Read More
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Oh Dennis! Thank you! Momma is trapped on something called a conference call and accidentally read this and had to mute so that they would not hear her laughing.
I love the suds and poor Miss Asta so perplexed.
What a surprise ending too. That Scampi was so fast I did not even know it was him.


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Good Morning,
Futures are lower again this morning, the DOW was down by more than 100 points, but is coming back just a little now, while the S&P took a run at 890 and is currently at 898 on the /ES, down about 8 points. Those are important points because it managed to break strong support at 900 overnight. The 890 level is now very important, it's where the 50dma and the 61.8% retrace line of the latest advance coincide.
The weekly initial unemployment claims number came down by 24,000 to 467,000 for last week, BUT the continuing claims, the total number of people receiving benefits, jumped to 4.6 million, the highest level since 1982. That number is also the number that is less manipulated. Tomorrow's monthly employment report is the most manipulated by seasonal adjustments, the BLS's death/birth model and so on. Be careful assuming that the report will be bad, I think that's already assumed after ADP's report yesterday.
Wal-mart, the GAP, and Macy's all warned about their sales over the holiday season, and Wal-mart said that they are going to miss their earnings estimate. That is a major blow to the retail space, most people were assuming that Wal-Mart would lead. Yet another example of how the stock market is not correctly priced for the true underlying economic conditions.
The Bank of England slashed their interest rates by another .5%, and took their bank rate down to 1.5%. Now you would think that would weaken the pound and make the dollar stronger, but in fact, the dollar is down pretty substantially this morning and gold is up.
Bonds are generally up in price/down in yield this morning, TLT is mostly flat with its close yesterday, however.
Financials seem to be a key to the market still. The XLF's failure to break the 50dma was very significant. This morning many of the financials are down and the XLF is down further as well.
Today's a very important day overall. We have now gone down to the 61.8% retrace level, close to the 50dma, and have so far bounced. We are oversold on the short term oscillators and that is providing a little support here. It seems to me that this is pretty much do or die in this area and I think using the 50dma as a short or long entry spot is a good idea, as long as you exit on a break that goes against you. Personally, I don't like the long side for anything more than a possible scalp as the daily stochastic just issued a sell signal yesterday and thus we probably have more sell off coming in the days ahead. But again, we must get through the 50dma first which right now is at 889 as you can see in the SPX chart below:
Keep an eye on the VIX to see if that is a false breakout or if it's real. If it continues higher today, there's a big clue for us.
That's about all I have, except another caution not to buy the media hype and B.S., I already see that CNN is running with a headline that says jobless claims fall sharply! I love the bias, the fact is that the media and most people are biased to be positive, and at the same time people are complaining that the media is being too negative about the economy. NO, they are not, they are still far too positive; people who are realistic about the economy do not get a commensurate amount of air time. Remember who owns the media and what their interests are!
Best to your day,
Thursday, January 8, 2009
Morning Update 1/8/2009
Posted byAmy Jamison at6:27 AM


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To celebrate Star Wars Day, we're giving away the best piece of merchandise to come out of George Lucas' films: the Tauntaun Sleeping Bag! To enter, you just have to show your love and appreciation for all things Tauntaun.
Dreamed up by the brilliant folks over at ThinkGeek, the Tauntaun Sleeping Bag is perfect for both junior and adult Wampas.
So how do you win this amazing creation? Simply enter out Tauntaun appreciation contest. Just submit a photograph, photoshop, t-shirt idea, graphic design, piece of existential art, video, drawing diorama, or photo that best celebrates everything Tauntaun. Heck make an LOL-Tauntaun, or turn in a picture of a drawing you made with crayons, we're cool with whatever — just be creative. Post your submissions in the comments below (and feel free to comment on who should win). The contest ends at at 2:00 PM PST tomorrow. We will notify the winner in the comment thread after the deadline has passed.
The only restriction is you MUST live in the US or Canada to participate for shipping purposes (sorry).
Here are the details of the lush Tauntaun bag:
Fully Licensed Lucasfilm™ Collectible, this classic Star Wars sleeping bag simulates the warmth of a Tauntaun carcass.
Features a built-in embroidered Tauntaun head pillow and plush Lightsaber zipper pull.
Plush interior, 100% Polyester construction exterior, and machine washable.
One size fits all (33"W x 67"L -not including head pillow or legs), which give enough room for adults and plenty of space for kids (ages 3 and up).
Retails for $99.99
Now get tauntaun slicing!


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I love all kinds of toffee, fudge and caramel flavours.
what is your favorite flavor of
Whatever happens to be in the frig!
It's definitely lemon or/and yogurt,but i also like strawberry.
Homemade peach using fresh peaches from nearby orchards is my absolute favorite. There's nothing more refreshing on a hot summer day! When I can't have that, I'm very partial to butter pecan.
I've only had peach ice cream once....from a small vendor with a roadside cart while we were vacationing down on Holden Beach....that ice cream was great!
I love Ben & Jerry's Karamel Sutra. It combines my two loves: chocolate and caramel. The soft caramel core is the best part though!!!!
coffee or peanut butter cup! But honestly, I'm really a vanilla girl because I love toppings!
Definitely Mint Chocolate, but before it was created my favorite was Chocolate! ^_^
Caramel and pecan! Raisins in rum is also fine!
are we talking about ice-cream.. mmm yum yum my favorite is: "chocolate brownie" have anybody taste this flavor.. 100% recommended
MOOSE TRACKS! And anything with peanut butter and chocolate.
My husband is the ice-cream monster in this house - he'd eat ice-cream cones even in the snow! I don't really have a favourite - vanilla maybe or mint choc chip?
peanut butter and vanilla or chocolate together and then any kind of fruit flavor
ditto moose tracks. It's the BEST!
I'm a vanilla kind of gal... Plain ole vanilla is my favorite, with Chocolate shell and Marshmallow toppings. I will have Moose Tracks now and then, but I would take vanilla any day of the week.
Rocky Road is a favorite, although this summer I started buying Orange Sherbet a lot.
Holly -- LOVE Bunny Tracks! I'm in Missouri (near KC).
Strawberry, coffee (but I don't like to drink it) and Pistachio almond.
Moose Tracks and Rocky Road!
When it's hot in the Summer and I have more of a craving for something fruity, I'll
get Breyers Vanilla Bean and in a parfait or even tall glass, I'll layer it with fresh fruit
and a similar Jello. Strawberry works great and is very refreshing on a hot day.
Cake batter!
5 months ago when I originally answered it was mint chocolate chip but over the summer I was introduced to Talenti gelato...the sea salt caramel is to die for! when I want a sweet frozen treat, that's my automatic go-to now
Vanilla. Yep, plain vanilla. If I'm feeling fancy, I'll get French Vanilla. LOL Not a lot of options with lactose-free ice cream anyway.
However, most of these other people in my house prefer "things" in their ice cream, so we usually get moose tracks or fudge ripple or mint chocolate chip. Of which I eat none.
I'm pretty much a fan of anything chocolate - Rocky Road, Mississippi Mud, Original Chocolate, but I'm downright addicted to Cherry Garcia by Ben and Jerry's.
I would buy a freezer just to keep a stash of it in so I never run out.
Chocolate has ALWAYS been my favorite but anything with caramel is closing in!
Black raspberry cheesecake.
Plain ole strawberry for me, but preferably Haagen Dazs, then it's not 'plain ole' anymore:)
Don't have Ben and Jerry's here.
Chocolate marshmallow made by Turkey Hill Ice Cream. Yum!
I try not to eat ice cream anymore, because I have a liver condition that is associated with my PCOS, but, I do always love chocolate ice cream....chocolate anything really. Also, I used to always eat fudge brownie ice cream. I've never tried fresh home made ice cream. I'd love to someday. It would be ok in moderation because then there wouldn't be any chemicals in it lol.
Chocolate with a chocolate crackle in it ... everything chocolate
there are so many yummy ones. My favorite brand is Ben and Jerry. But there is one flavor that always makes me happy, and it is one of the simples ones: vanilla chocolate chip cookie dough. But I think it is more about the memories I have than actual flavor. The first time I tried it was in 2003, I think. Back in Poland there are no cookie dough ice cream, I was 21 years old when I ate cookie dough ice cream for the first time, it was in London on my first independent travel adventure. I felt like a little girl when I tried it. And since then I always reach for vanilla chocolate chip cookie dough ice cream.
Vanilla and passionfruit....


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Let $G$ be an algebraic group with Lie algebra $\mathfrak g$ and let $\Gamma$ be any finitely generated (discrete) group. One can consider the representation variety $\mathfrak R=\mathrm{Hom}(\Gamma,G)$. If one considers the group scheme $\mathfrak G$ associated to $G$, there is a nice argument that shows that infinitesimal deformations of a homomorphism $\phi\in\mathfrak R(\mathbb R)$ are the (Zariski) tangent space to $\mathfrak R$ at $\phi$ given by the kernel of the map $$ \mathfrak R(\eta)\colon\mathfrak R(\mathbb R[\epsilon])\to \mathfrak R(\mathbb R) $$ where $\mathbb R[\epsilon]$ is the algebra of dual numbers and $\eta$ is the augmentation $\eta(\epsilon)=0$.
One checks that $$\mathfrak R(\mathbb R[\epsilon])=\mathrm{Hom}(\Gamma,\mathfrak G(\mathbb R[\epsilon]))=\mathrm{Hom}(\Gamma,\mathfrak g\rtimes G) $$ and $T_\phi(\mathfrak R)$ is the fibre of $\mathfrak R(\eta)$ over $\phi$, i.e. homomorphisms into $\mathfrak g\rtimes G$ that project onto $\phi$, which must be of the form $\gamma\mapsto(\tau(\gamma),\phi(\gamma))$ for some function $\tau\colon\Gamma\to\mathfrak g$. Finally, the requirement that this homomorphism be indeed a homomorphism implies that $\tau$ must be a $1$-cocycle, i.e. $\tau\in Z^1(\Gamma,\mathfrak g)$, where $\Gamma$ acts on $\mathfrak g$ via $\phi\colon\Gamma\to G$.
My question is, whether the above is also true for Lie groups, which in general may not be algebraic groups.


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The results of the studies documented in this review suggest that there is a great deal of variability in the approaches taken by firms for establishing materiality. Such differences in materiality methods can affect both the effectiveness and efficiency of audits. For example, if firms differ in how they allocate materiality to financial statement accounts, then the scope of the work could differ across audits with similar characteristics. Auditors also appear to differ in terms of the factors they consider for determining the materiality of internal control weaknesses, suggesting that auditors may need more structured criteria to make materiality judgments about internal control weaknesses. Materiality judgments are influenced by authoritative guidance, suggesting that standard setters and audit firms have the ability to influence auditors' materiality judgments by providing auditors with specific guidance.
Messier, Jr., W.F., N. Martinov-Bennie, and A. Eilifsen. 2005. A review and integration of empirical research on materiality: Two decades later. Auditing: A Journal of Practice and Theory 24 (2): 153-187.
Firms should consider the levels of accountability pressure and situations where they use them and consider how different levels of pressure may impact performance. Higher levels of accountability pressure may increase effectiveness and increase the likelihood of finding material misstatements.
On the other hand, increased effectiveness and time spent due to higher levels of accountability pressure may cause inefficiencies and result in unnecessary effort. Firms should evaluate the costs and benefits for their situations.
The authors note that this study only looks at the effect of accountability pressure from an unknown partner. In the real world, auditors have accountability pressures from many levels such as other superiors, clients, regulators, and audit committees.
Further, the auditor may have assessed things differently if they knew the partner that was performing their review.
DeZoort, T., P. Harrison, and M. Taylor. 2006. Accountability and auditors' materiality judgments: The effects of differential pressure strength on conservatism, variability, and effort. Accounting, Organizations, and Society 31 (4-5): 373-390.
The results of this study are important for auditors to consider when making materiality judgments. The evidence indicates that auditors are more likely to overlook the qualitative importance of adjustments that affect a client's ability to meet or beat analysts' forecasts. Furthermore, findings suggest that auditors are more lenient with subjective audit differences. The study suggests that providing auditors with guidance on qualitative materiality may improve materiality judgments, but it does not completely alleviate the differences among the earnings benchmarks.
Ng, T.B. 2007. Auditors' Decisions on Audit Differences that Affect Significant Earnings Thresholds. Auditing: A Journal of Practice and Theory 26 (1): 71-89.
In light of cost reductions in data generation, storage, retrieval, and transmission, the inherent compromises within the paper paradigm are of little benefit. Users are entitled to more in-depth, granular values that they can manipulate, drilling down and up for more or less detail where needed. Financial reporting standards that govern presentation and arbitrary aggregation must likewise give way to rules regarding the limits and frequency of data transmission, as well as the quality of those data.
Audit standards must change as well. Error detection and risk quantification are no longer sufficient targets, but must be seen as small components of an audit of broader scope. The deep analysis of tremendous volumes of data and potentially thousands of exception reports necessitates a different paradigm of reporting and assurance. The role of auditing standards, far from being diminished in the face of increasing automation, must shift from governing sampling procedures to embracing the broader, deeper data availability and analysis of the modern era in an effort to create a better, more thorough audit.
Krahel, J. P., and W. R. Titera. 2015. Consequences of Big Data and Formalization on Accounting and Auditing Standards. Accounting Horizons 29 (2): 409-422.
Individual auditors have wide variations in the materiality thresholds the auditors use to assess qualitative materiality. Greater clarity in materiality guidance can potentially reduce the variability in auditors' materiality threshold judgments pertaining to qualitative materiality factors.
Ng, T. B-P and H. T. Tan. 2007. Effects of qualitative factor salience, expressed client concern, and qualitative materiality thresholds on auditors' audit adjustment decisions. Contemporary Accounting Research 24 (4): 1171-92.
The findings of this study are relevant to financial reporting standard-setters and regulators interested in the effects of financial statement presentation standards on the reliability of the information presented, to auditing standard-setters and regulators who have a responsibility to clarify auditors' responsibility for misstatement in disaggregated numbers, and to audit firms that must provide guidance to ensure consensus in their auditors' judgments. Standard-setters should also consider the fact that FASB has also been considering issues related to balance sheet aggregation or netting of balances. As a consequence, the importance of the effects of aggregation on auditors' materiality judgments may be broader than the focus of the current study.
For more information on this study, please contact Robert Libby.
Libby, R., and T. Brown. 2013. Financial Statement Disaggregation Decisions and Auditors' Tolerance for Misstatement. The Accounting Review 88 (2).
The proposed component materiality method helps the group auditor develop and document a rational plan for achieving the group assurance objective that is rooted in applicable auditing standards and decision theory.
The significant differences in results between the proposed method and the alternatives suggest the need for guidance more definitive than that provided by current auditing standards. Indeed, the authors' approach could be a useful metric for evaluating the efficacy of methods that do not have as comprehensive a supporting theory.
Field deployment of the proposed method requires software support. A specific implementation is available as an Excel app at http://raw.rutgers.edu/GUAMcalc.
For more information on this study, please contact Trevor Stewart at email@example.com.
Stewart, Trevor R., and William R. Kinney, Jr. 2013. Group Audits, Group-Level Controls, and Component Materiality: How Much Auditing Is Enough? The Accounting Review 88 (2): 707-737.


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|Catalog Number:
|Output Amps/Volts:
|Ship Weight:
|11 lbs.
This Leeson product is Non-Returnable. Please take the time to identify your product needs. It is the customer's responsibility to review all product information provided to determine the correct mechanical and electrical characteristics needed for your application. If you need further assistance with this product to identify your product specifications, please contact our sales team to answer any questions you may have.
LEESON Speedmaster Micro Series compact inverters offer "big drive" full features for adapting standard or premium efficiency three phase motors to adjustable speed operation. Complete, rugged WASHGUARD Food Safe Epoxy Coated enclosures for NEMA 4 (IP65) and NEMA 4/12 protection. No external cooling fan required on NEMA 4 (IP65) drives. NEMA 12 drives have external cooling fan. Fully Gasketed, water, oil and dust-tight enclosure. These Speedmaster Micro Series drives have the same features as the standard NEMA 1 units.
- Intelligent Power Module-IGBT's with a 16 bit Intel Microprocessor.
- User choice programming with: Choice of "Quick Start" factory presets and Built-in English programmable options via the key touch-pad.
- Output Frequency: 0-120Hz
- Overload Current Capacity: 150% for one minute, based on nominal output of the control.
- Speed reference signal. Choice of potentiometer, 0-10VDC, speed or load.
- Two auxiliary contacts: One form C relay and two open collector output.
- Preset speeds: Four.
- Slip Compensation.
- Adjustable carrier frequency. Adjustable acceleration and deceleration times.
- Forward/Reverse.
- DC braking-time and voltage adjustable.
- Password protected.
- Constant torque-with adjustable current limit.
- Rugged, heavy-gauge steel enclosures with barrier type terminal strips.
- Underwriter Laboratories Listed.
- Dynamic Braking is available as a kit for Installation in the field.
- Remote keypad is available as a kit for installation in the field or as a modification.
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Venezuela's Maduro marries longtime companion
CARACAS, Venezuela – Venezuelan President Nicolas Maduro and his longtime companion, former Attorney General Cilia Flores, have married in a civil ceremony.
Maduro made the announcement Tuesday on state TV during a meeting with allied governors.
The two wedded in a ceremony presided over by the ruling socialists' Caracas mayor, Jorge Rodriguez. Maduro tweeted photos.
Maduro and Flores have been a couple for two decades, ever since the failed 1992 coup led by the late President Hugo Chavez. Chavez's longtime foreign minister and chosen successor, the 50-year-old Maduro was elected president on April 14.
Flores has three children, Maduro one, both from previous unions.


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Do you have problems with Picajet stalling, freezing, and/or crashing?
Picajet has never stalled, frozen, or crashed.
[ 1 ]
Picajet occasionally stalls, freezes, or crashes.
[ 2 ]
Picajet frequently stalls, freezes, or crashes.
[ 4 ]
Picajet stalls, freezes, or crashes every time I use it.
[ 1 ]
Total Votes : 8
Joined: 18 Nov 2005
Posts: 35
Posted: Fri Nov 18, 2005 6:09 pm
Post subject: Problems and Suggestions
I emailed support and really didn't get much of a response, so I thought I'd try the forum and see what resulted from it.
I also saw that ther weren't very many polls. The polls seem to be a good medium for finding out how many people have certain problems or a way for the programmers to see how important certain features are to the consumers. I put up a poll to test this theory.
I just bought Picajet to organize my photos a last week and I've already run into several problems including:
-The program sometimes closes itself with no warning.
-The program stalls for up to 15 minutes at a time with no indicator that it is doing anything. It would be nice to have a status bar that shows what it is doing and how far along in that process it is.
-Sometimes when it stalls, it never starts working again and has to be stopped via the taskmanager.
-I've had subcategories randomly separate themselves from their category and end up at the bottom of the category column.
-The category counts are frequently very wrong. In one subcategory with 16 pictures, it says there are 347. Another subcategory says it has 21735 pictures in it when the "All Files" category says it has 18689 pictures.
-The help file is very lacking. At the very least, it should give an explanation of each function in the drop down menus. A thorough manual would be better.
-The duplicate search function appears to only work on pictures you've looked at recently. I had to run it 5 times before I found all of the duplicates in one of my smaller categories. It wouldn't recognize pictures
as duplicates until I had viewed it as a thumbnail.
-It would be nice to be able to cut and paste subcategories. Sometimes I have to drag and drop a category several times before I get it where I want it. Another possibility would be to have it set up like windows explorer by having the option to have two identical columns of categories/subcategories where you could drag subcategories from one column to the other and put the right where you want them.
-The program has offered me several times to report bugs when I'm offline. Is there a way that the bugs can be logged and sent later?
Other suggestions I have:
-Have an option to automatically alphabetize all subcategories. It's very annoying to have to do it individually for each category and subcategory and having to re-do it everytime you add a new subcategory.
-It would be nice to see a one and multiple level subcategory count for each category and subcategory.
-If you want a certain picture as an icon, it would be nice to be able to just drag that picture and drop it onto the icon you want to replace.
Overall, it's a nice program with a lot of potential
once the bugs are worked out.
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Joined: 21 Feb 2005
Posts: 37
Posted: Mon Nov 21, 2005 10:24 am
Post subject:
I second all of that. I've stopped using my registered PJ months ago because of the many bugs, the skinned interface and the lack of a manual.
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Howard Zinn
Howard Zinn, professor emeritus at Boston University, was perhaps this country's premier radical historian. He was born in Brooklyn in 1922. His parents, poor immigrants, were constantly moving to stay, as he once told me, "one step ahead of the landlord." After high school, he went to work in the Brooklyn Navy Yard. During World War II, he saw combat duty as an air force bombardier. After the war, he went to Columbia University on the GI Bill. He taught at Spelman, the all-black women's college in Atlanta. He was an active figure in the civil rights movement and served on the board of SNCC, the Student Nonviolent Coordinating Committee. He was fired by Spelman for his activism. He was among the first to oppose U.S. aggression in Indochina. His book Vietnam: The Logic of Withdrawal was an instant classic. A principled opponent of imperialism and militarism, he was an advocate of non-violent civil disobedience. He spoke and marched against the U.S. wars on Afghanistan and Iraq. His masterwork, A People's History of the United States, continues to sell in huge numbers. Among his many books are A Power Governments Cannot Suppress and Original Zinn with David Barsamian. Just before his death, he completed his last great project, the documentary The People Speak. Always ready to lend a hand, he believed in and practiced solidarity. Witty, erudite, generous, and loved, Howard Zinn, friend and teacher, passed away on January 27, 2010. His words inspire many the world over, "We don't have to wait for some grand utopian future. To live now, as human beings should live, in defiance of all that is bad around us, is itself a marvelous victory."
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