text:
Please change drop rate for specialization collection 8th item (more like the caffeine skritt? )
Okay, so while I am really really really happy ( ) with PoF thus far and I enjoy all the subtle changes that were made (and of course the big sweeping ones too) I have found an aspect that is not so enjoyable. We have been working on finishing our achievements and moved to the Specialization Collections. It started out really strong in that we were completing the items task quite enjoyably. Despite the trolls prematurely spawning the caffeine skritt so that it fails. Then we reached the 8th item on the list (for example: "Raidmarshal Bayonet") / Identifying gear / Trade Post Purchase items. We have opened stacks of Fine, Masterwork and Rare gear bags using the "Use All" command while magic Find was above 420+ and they just are not dropping. Usually I am the one things do not drop for but now my wife is also waiting on the specialization collections 8th item. That's what prompted this post, since during map chat (ooops yes, I used it ) there were reports of others farming just for those weapons. While I think some might like the buy from TP option that just is not fun for me. I would rather have a designated target or something to do to be rewarded with that drop. For those of us on the bottom of the drop + MF spectrum please change the drop rate for these items (more like the caffeine skritt? ). Oh, sure I am getting tons of exotics from PoF just none of the ones I am looking for for Achievements
Edited~ Okay, so not so bad! I completely forgot about Chest of the Desert Specialist and it was how I got my first 2 weapons also. Unfortunately it was after I did the yucky and bought the remaining 7 I needed YAY for PoF Meta's Thanks for making them tradable
Mounts are nice, otherwise it's just more empty maps with hordes of hard hitting mobs that is not impossible but more annoying to explore.
Getting to the Jackal was a pain as I had to run through hordes of enemies to get there.
Griffon mount? Unlikely as I won't be finishing PoF solo anytime soon....
Other than that, totally worth the money.
Can't wait for the next expansion I can't do anything on without a massive zerg...
(massive sarcasm but I have had a long day.)
I just did the Griffon collections, and I just get my griffon mount but i feel kinda upset and disappointed about it after I spent many valuable golds and efforts, and what I get is a next level glider... I expected more from a flying mount, at least to fly up without any high height position requirement... So if possible, please fix it. Btw, everything is awesome, I am just not satisfy with the griffon, that's all.
I love mounts. I don't know how I survived so long without the bunny. hugs bunny Oh bunny mount, you make map completion so much fun! And Griffon, so worth the effort it takes to get it! SO much fun to just build up speed and zoom around maps. No more wasting money on waypoints. Timberline falls was already my fav map for gliding, but with griffon it takes on another level of wow. I agree it'd be fun to see some more meta's in the main POF maps, or some more group events like the casino ones, where it's not necessarily a fight but players work together - particularly big events where various parts of the map all need help and some co-ordination. Just not too many of the auric basin "whoops someone did 1hp more damage than they should have now you have 1 minute to not fail this whole thing" though. Not that I don't like AB's meta but wow it's touchy. (are there meta's for the other maps in pof?)
.... I think the only thing I gripe about in GW2 lately is there's too much nerfing in PVE - nerf PVP all you want I couldn't care less about it - but leave PVE awesomeness alone, sometimes it's nice to kick a bit of butt! We're not all uber el3te g00nlord sockpoopers. Some of us are old women with bad eyesight and terrible reflexes!
"... sockpooper" OMG, that's awesome..lol That's the first time I had every heard that
What I find good in the expansion was the story, I like it more thank the HoT one , I even find the death story part creative as it shows us what happened until now. Mounts was a good idea, made a lot easier the traveling across Tyria. Even though these are desert maps, I dont find them boring, I think they made the best of them, even the snowy part fits the map.
What irritates me is that there are a lot mobs on the maps and they shoot off the mounts easily and make the traveling harder in the new maps.
I'm in the big fight with the golem as I type It's killing me over and over while I browse the forum.
The PoF builds aren't what I want to play. Hence, I don't have the firepower to destroy the protector golems fast enough to get to the main golem. I've been at it for close to 2 hours. At this point I feel trolled.
I don't raid because this game is not one that compels me to want that kind of scenario, ( though I go on Urzog's runs in GW1.) Why put that kind of content into a story mission?
~edit~ After a break for afk and forum, I returned and finished the fight. It's an interesting story and I love the tribal practices detail. I realized that in this final phase of the fight I could brute force it by simply banging away at the golem.
Mesmerizing Girl
The story instances are much too long, given there are no intermediate save points that survive exiting the instance. My internet hiccuped and kicked me out when I had almost finished The Departing, and I had to do the whole thing again. Then once I had almost finished it again (I had listened to Joko's offer) I got kicked out again. Needless to say I gave up for the day. You should either make the instances much shorter (at least by a factor 3 or so) or remember the latest checkpoint so that you can (optionally) enter there.
Talking about too long, the boss fights are waaaayyyy too long. What exactly is the fun in being forever killed and survived by Balthazar until you finally manage to down his health to 10% or so? The story idea is OK, the execution is not. Again, make this much shorter. Same with other way too long fights, e.g. the one where you have to keep dodging circles forever. This gets old fast, shorten it significantly.
Would love to have a feature to skip the intro mission if you've already done it on another character. Doing the mission for the 9th time is a bit of a drag. Especially since it has no check points in it and being DC'd at any point means you have to restart the entire thing over.
@Riff.1037 said:
Would love to have a feature to skip the intro mission if you've already done it on another character. Doing the mission for the 9th time is a bit of a drag. Especially since it has no check points in it and being DC'd at any point means you have to restart the entire thing over.
you mean map scrolls?
I Have No friends, so I Must pug
@Gaile Gray.6029 said:
New forum / same request:
Please share your high-level feedback about Guild Wars 2: Path of Fire in <100 words.
This is our traditional request for your main points of feedback about our newest release. Please share your likes, dislikes, suggestions -- all are welcome. But please keep these comments to 100 words or less, and join or create other threads for a more in-depth conversation on a specific topic.
Thank you for sharing!
Love the game, but am increasingly concerned at the focus on dexterity and timing as mechanic; design choices for encounters are now pushing threshold on my ability to play. Am sad.
@derd.6413 said:
you mean map scrolls?
Thought those were only for LA? searching for that did lead me to the Lily of Elon item as well as the Spearmarshal's Plea huzzah!
@Riff.1037 said:
@derd.6413 said:
you mean map scrolls?
Thought those were only for LA? searching for that did lead me to the Lily of Elon item as well as the Spearmarshal's Plea huzzah!
you can also buy one for season 3 and 4 maps. there's even a book for it.
I Have No friends, so I Must pug
The Good:
I love several new elite professions.
I really love new maps looking, the desert, the music, the aesthetic, very well done. I liked that the LORE had LESS characters, so they can have more screentime, HoT had just too much stuff going on.
The story was fun to do most of the time.
I like mounts, but I do not like the flying mount. I think it kills a lot of interaction with the players.
The creativity of several puzzles
The bad:
Some maps are really annoying to explore, the way that mobs are placed and their range of aggro/atacks it's very badly done in several cases, too much.
Optimizacion still pretty mediocre, the game runs a little better than HoT maps, but still not enough.
Balzatar as a villan had much more presence and dialogs. But he still being very one dimensional and just a flat character that is mostly a stereotype. You guys need to give villians good motives to be evil.
Some characters get VERY flanderized, specially Rytlock and Canach. They are the same characters from start to finish,they barely show expressions other than being sarcastic and mocking, really anoying. Taimi also became too annoying, these characters should have SEVERAL characteristics, stop writing them in such an indimensional way, make them deeper, more vulnerable. Make them express more things. Rytlock involving on Baltazar escape was just too stupid, just no.
The character that I really liked was Kasmeer, we can see her strugging with her faith, she changes, not is the best way, but I'm glad she had decent development.
To Kill a God achievements were... challenging.
Definitely fell in love with PoF. The reminiscent feel of GW1 lore coming to life before my eyes was fantastic. It was tied together very well. I love the mounts, and really wish more was done to bring back the armor of the Ancients beside the Funerary weapons and armor!!!
Make the champion bounty Silkears easier, he's almost unkillable, with 18 ppl we managed to almost take half of his hp. ppl are skipping him because he's a pain so ill never get this done. This is supposed to be a champ while the legendary bosses are easier to kill with groups this size.
edit: 28-3-2018 - I got him down, it took about 40+ ppl to do it and we got him in the last 30 seconds.
Nice kitten you guys playing
Stop playing it halfway, the Mac client was forcing my Mac Pro with 12 cores and 64gb of ram to shut down because of the heat. Anyway now with the spyware stuff I don't plan to reinstall it. Also Weaver just isn't fun and the lack of competitive content is a huge deception.
I am not done with the story, but so far I prefer HoT. I still spend a majority of my time in HoT maps/content. I feel the maps and content was interesting and challenging. Not to mention beautiful. The story and music was extremely well done as was my favorite thing about HoT. So far in PoF I find the following:
1. I was not a pro for mounts, but I am impressed with how they did them. Not only do they each have purpose but they have weight to them (physics). They feel more real. I like that they did not make permanent free flying. I think they really tried to create a fair balance with them.
2. I am strictly a ranger player. I have enjoyed the Soulbeast very much. Both Elite specs have been extremely fun to use. Though I cannot compare them since they have different play styles and purposes.
1. I am currently forcing myself to go through the story. It has not been very interesting for me thus far. I feel like with HoT I was at the edge of my seat.
2. I noticed some of the music was recycled. Same as Silverwaste/Dry Top. Just an observation.
3. Though I understand it is a different type of environment, I just personally prefer the jungle maps over the desert maps. I do not feel they are as interesting.
4. I enjoyed the challenge HoT brought, and it feels like PoF was not very much so.
"Nothing clears a troubled mind better than shooting a bow. "
I do not think either expansion was keeping to the spirit of GW2. They were both like ORR in that mobs were just thrown across the map to do nothing more than obstruct. No immersion at all. Of the 2 POF is the better experience. HOT was too much of a closed, channeled world for my tastes. Other than adding some extra accessible HP and MP I do not see me spending even a fraction of my time in HOT as I will in POF. In the end both expansions were like a throwback to old NES games. The game is now just a mount focused, large jumping puzzle.
Current Events: We should not be made to remember which character we did what with when we did a thing that time that it's not our responsibility to remember.
When you write a current event, if any of your characters did a pre-requisite for something, then you should be able to move forward with any character.
That's it.
Irwin M. Fletcher
P.S. Have a nice day.
In the event I don't get a chance, thank you all for the company and help when I needed it from time to time.
Well said.
Great expansion.
Love the mounts and professions. Made me and my friends play GW again.
Glad about populated maps through multiple events. Exploration feels great, and even better than previous instalments.
Vabbi needs serious rework of either rewards or mechanics. It's absolutely empty.
Other maps have champ/HP trains, commanders and, most important: crowds.
Vabbi is completely empty apart from 2-3 lost souls doing 100% of the map.
Shame, espesially considering how beatiful it is and well-crafted it is.
I don't like how Mastery System is being handled in the open world. Press 'F' to channel... this is so shallow. I understand the lack of time/resources to make all mastery points interesting like the Sous-Chef one. Isn't making masteries cheaper and not adding braindead 'channel' ones better?
Second thing Hero Point System. The game gives us more Hero Points than we need to unlock elite specs. I get that there can be some spare Hero Points. But there is way too many. I have both elite specs fully unlocked and 403 Hero Points left. I can unlock next elite spec once expac 3 hits without even playing it. It completly devalues the system.
I am afraid that masteries are going in the same direction. They are being thrown at us and once new expansion hits all what's left will become useless. 20+ spare Central Tyria Mastery Points, 40+ HoT ones. It's barely 6 months past PoF and I already have 13+ unspent Mastery Points (haven't even touched Vabbi & collections). At least Mastery Points are unique to the expansion unlike Hero Points.
Unlocking elite specs in PoF didn't feel interesting compared to my HoT experiences because of spare Hero Points. This is gonna snowball in the future if not adressed and solved.
I love the maps, the story and all. But having just gone back again after quite awhile for map completion I was reminded again how solo-unfriendly these maps are.
With lower and lower population it's definitely time to lower the HP and prob some attack power of everything "forged". Basically scale it reasonably for 1 person on a well geared toon doesn't down more than a few times in the course of simple mapping. Events are one thing, but hearts and PoI's and whatnot should be SOLO-Content.
(No I'm not new, and yes i know how to run my toons and how to build them)
I loved the setting, landscapes, architecture, textures, the atmosphere. I enjoyed seeing all the places from GW1 again. Also like the new Guild Hall. The story was really good but would like it even more if I could play story with friends without troubles. The mounts are amazing and add so much to the game but feel like they should always have been there. I really appreciate that the Mastery Points are actually doable without frustration (unlike the adventures in HoT). The only disappointment for me was too little water at the Elon River and not finding underwater combat there.
Loved 95% of PoF but it was trashy when it comes to the expectations of the Griffon quest.
Absoloutely hated having some days where you'd have lots of people joining you for quest boss's, and some other days or times none wanted to show up. And they didn't have any insentive to show up with a pointles event that offered nothing for them.
Had a thread about it few weeks back.
We really shouldn't have to worry that there will be a day when new players (maybe a year from now) will find it nearlly impossible to complete certain events, unless they beg their guildies to help them.
Revisiting content should be fun, but the quest bosses add no rewards and are a hassle that far too few would want to re-do (excluding bounty missions because they offer something that brings in the players, as oposed to say the event against Jabari to free that dudes wife... / for the griffon quest, but give no decent reward to make people want to go there).
Positives: The Bountys were great incentives for quests - rewards for all even those not doing mount quest, and it kept people coming back for more.
Cons: Non bounty boss events that require groups, with the purpose of doing certain mounts or mastery quests, hinder progress, in the long run.... as each expansion eventually lose interest from people. As the years go by... and newer stuff comes out (thuss making more work for you, to re-think certain quest and make them more do-able to any players who only just started them) .
< hectoword?
Liked HoT: +high challenge. Liked the maps. Like 3d maze. Navigation challenging. Liked the Mordrem as foes. Story took time.
PoF? PoFui. Not so much. Maps too easy. Foes too easy. Story too easy, except for the fight with Balthazar. Story felt too short.
Not that there wasn't some challenge; there was. But not what I'd come to expect after HoT. Exploration of PoF areas was easy. Not even all that dangerous (tho some obviously disagree). Soloed the story. Soloed exploration of most of the areas. Very few challenges needed a group.
Liked mounts, though. Rest was underwhelming. Story was too short. Some (most?) story challenges were too easy. Seriously.
Griffon quest was tedious & boring. Didn't care for it.
Much preferred HoT.
@Meviken.2054 said:
Liked HoT: +high challenge. Liked the maps. Like 3d maze. Navigation challenging. Liked the Mordrem as foes. Story took time.
PoF? PoFui. Not so much. Maps too easy. Foes too easy. Story too easy, except for the fight with Balthazar. Story felt too short.
I did a check last week to see which has the shorter story, HoT or PoF. To get an accurate result, I did explore all maps 100% prior to doing the story missions, and it turns out that HoT is in no way longer than PoF. That's just your subjective feeling. Also, the difficulty level (enemy- and fight-wise) of PoF is definitely higher than that of HoT (counting in the use of the new elite specs).
: awesome list: mounts, new music, the look of the maps, the architecture in maps, visible animations of enemies, no annoying enemies like in HoT.
list: I would have loved to have a less standard evil main villian. Joko should be more funny. I would have liked more references to abaddon or his margonites. And Vlast .
Serpent's Ire needs to be fixed. The difficulty is poorly tuned, resulting in a failure rate around 90%, and the rewards are so pitiful that most people have no reason to do it outside of getting the Funerary Collection and the Golem Backpiece recording. This results in massive frustration because there is no community learning to do it or organizing, just a bunch of random people beating their heads against it and then never returning to help the next set once they beat it once.
The return of the Rollerbeetle prompted me to write some creature design feedback. I love the Nightfall creature designs, and with PoF, I was generally disappointed that very little of that carried over:
I haven't played the new episode yet, but I'm hopeful it'll include some classic Kournan wildlife.
1 - 10 scale, (1=worst, 10=Amazing)
Story 9/10
Extremely well done in the storytelling. Plot is personal preference. Branching dialogue like swtor would be a HUGE improvement!
Mounts 9.9/10
My only criticism is that there should be way more skins for each mount, and it would be cool to see skins that could change the shape of the animal. Like turn the skimmer into a bat or a hoverboard.
As for the implementation, best mounts in an MMO ever!
Path of Fire was a great addition to the game, had a lot of fun playing through the expansion and the mounts are implemented excellently. After playing through the story, collecting all the mounts etc and completing the S4 living world episode, I'm now running through each of the PoF maps for 100% completion.
While the maps themselves are fantastic, offering lots of variety in environments, interesting locations and events, and some great encounters, I'm very disappointed by the return of the repeatable hearts from LS3. I appreciated that Heart of Thorns and the endgame zones of the base game had moved away from this grindy, repetitive gameplay format, and it's a shame to see them return. With nearly 20 level 80 characters on my account, the hearts themselves were my least favourite part of the base game, and became a huge chore especially after multiple playthroughs.
The prospect of having to run through all the hearts is why it's taken me almost a year since PoF's release to finish the zones - each heart takes far too long to progress and having them reset each day is just salt in the wound when I find out that collections and items require purchasing items from specific vendors. I understand that it's intended to add replayability to the zones and extend gameplay, however I feel that despite this, Heart of Thorns offered far more replayability through the addition of map metas, and that this is a step back.
I implore you to revisit this in upcoming content, and hope that future hearts, should they be included in the next living world seasons or expansions, only require one time completion for at least keeping access to the vendor open.
Path of Fire is very watered down, too simplified, dumbed down, and unchallenging. I was very disappointed about the PoF playthrough. The next expansion should be as challenging as HoT, just with less confusing minimap. The HoT world design was BRILLIANT and awe striking, it was just the poor minimap that made navigation impossible!
Games are supposed to be fun. I realize that everyone's definition of fun is going to differ. ArenaNet considered the fact when they built GW2. We have several different activities to please several different kinds of gamers. I am a veteran solo player. I bought the game before it originally released. I am a world explorer. I don't play the Dungeons/Fractals or PvP or WvW. I have dabbled in them, but I decided I didn't care for them. They are too punishing for me personally.
I play the story, craft, gather and sell, explore maps. The only 'group' play I participate in is when I use the boss timer to travel between bosses and there are other fellow players there.
The old Orr map exploration was too punishing. The Heart of Thorns and Path of Fire maps are too punishing. When a map is too punishing it is no longer fun. The story in Path of Fire is too punishing as well. I brought a friend and we both died many times. That's ridiculous in my not so humble opinion. I hate the red circles. Why do we have dodge? You can dodge a couple times and the red circles follow you. You no longer can dodge. You run out of dodge juice. The red circle that followed you kills you. It's dumb. It's not fun. I won't participate in that. At level 80 in elite gear I should be able to handle the trash on the expansion maps. I've earned it. But no, I'm punished with no end in sight.
I want to revert my account back to GW2 only without the expansions because my 'dailies' force me to go into the expansion maps which I hate. I created a free account in addition to this account so that I could have my dailies only in main Tyria. I looked into upgrading that account to GW2 only, but the upgrade forces the expansion(s).
I wish there was a way I could roll back my main account to before I purchased the expansions. Or a way I could upgrade my free account to GW2 only without the expansions. There's not many things I hate in life, but I hate the expansions. They cause me stress and they are not fun.
TDLR: I want to remove the expansion content from my account or upgrade my free account to GW2 only without the expansions.
In my feel, it's a small request. I crave for more "simple" mounts. The mounts' look is often either occupied with effects or armored like you're an elite soldier. While story-wise this may be true, it's not really what I have in mind with my character's aesthetic.
To be honest, I really wish for a yellow Moa mount. The one you ride in Final Fantasy, the one you ride in Ragnarok Online. I just love them, it really stick to me since I saw them as a child.
-I liked how the main story was narrated
-Mounts are fun.
-More and more I can see how GW2 lacks replayability in the new expansions, it makes it hard for people that enjoy that kind of content, like me, to stay engaged between different content releases.
-There is no real meaning for me to replay the story. No branching story, not even 1 different mission or meaningful dialogue based on the class/race.. I was going to replay with some other characters to get the other armor classes of the sunspear set but I quickly realized I already had all the sets since unlocking one piece by the story unlocks light, medium and heavy armor.
-Being able to go with the skimmer in the toxic zones took away the feel that those were unaccessible zones... I would have liked to have the Junundu Wurms instead.
-The specializations system already started to feel old and not so interesting.
-The devs missed the opportunity to give to the fans the Dervish as an elite specialization and spears as a land weapon maybe with a sunspear/paragon elite specialization.
-Not being able to mix specializations and related weapons limits the fun.
My opinion:
1. The story is enjoyable except the looooooong boss fights. I do not want to do the story again because of that.
2. The maps are the most beautiful ones so far, however, they are also aggro-hell and it just takes too long to kill mobs. More waypoints please.
3. The mastery system has been vastly improved. Much more enjoyable.
4. The mounts are mostly fun to acquire though the roller beetle is unnecessarily long to get and the griffon unnecessarily expensive. This would've been different if they weren't required for map completion/mastery points.
"In my experience, if you can't say what you mean, you can never mean what you say. The details are everything." ~ Minister Durano
What HoT bring to GW2
-A lot of adventure, really diversified and funny (Tendril torchers, salvage pit etc...)
-Same for Mastery, Itzel poison resistance, mushrooms etc...
-Meta event really amazing
-Really good spécialisations
-4 Raids with a very good story, spread on 3 raids and 1 bound to this scenario like an epilogue
What PoF bring to GW2
-Two news adventures. Just two. Supply run and Griffon. Really annoying btw
-Mounts, they are very cool but, meh, is not really original, but they are really cool yeah
-Meta really annoying and not interisting at all ! Seriously ! A fight against an Elder Dragon in HoT and 4 Branded Forgotten in PoF ? the five maps of Pof are really empty because we have nothing to do.
-Bounty, meh just some boss. Okey, but nobody cares, they are not interesting. Just another farm for another collection. Why not one or two really big World Boss like GW2 base game ? It would be really more impacting.
Great expansion. I've been a fan of both games since beta/launch. Thanks to everyone at ANET for the great work. I know it is a career but this studio is doing great things. One can only imagine what it is like to see your designs enjoyed or criticized by players and publications.
Overall, I enjoyed the expansion. Our return to Elona was fun and nostalgic. Sharing personal POI's with my wife, as we played, was something that improved the experience.
1. Mounts - Game-changing in every way! Opened up a new way to explore the game while adding a previously untouched dynamic to re-visiting old maps.
2. Maps - As I said before, Elona looks amazing. The mix of old and new from Nightfall is relieving. Large with a verticality that is different from base GW2 and HoT.
3. Characters - Appreciated seeing more POC in the game. The hairstyles, skin tones and clothing allowed me to embrace more of my ancestral culture while making a PC that I could more closely relate to.
4. Story - Gods, Joko and politics. This story really put into perspective what the situation is truly like for the races of Tyria. Plenty of humor, suspense and moments that raise the stakes.
I'm not a fan of the hearts Even after they are repeatable they are quite the chore to do. Their rewards are okay but I really don't feel they need to be attached to a heart. The group events have been a bit weak, even on the living world maps although an improvement over base PoF. I do really like the involved meta events of HoT a bit more. And lastly you could have added more armor skins.
-They really contribute to getting around Elona, because the maps are so damned big, something I appreciate; the mounts feel like they belong to the expansion, rather than being put in for marketing.
-They also make getting around HoT far more tolerable as well, with the added bonus of less visual clutter on the map (such as updrafts, leyline channels being together in one place)
-Broke navigating the base game over it's knee but they're fun and I enjoy them. Also helpful for finding where a jumping puzzle is.
-I know it's a 'bonus' mount but cripes the Gryphon is expensive. Not everyone has 250g down the back of the sofa, though you at least made it 25g chunks. I much prefer the roller beetle's system; a bit more of a grind/faff perhaps, but free. Please, if you do this again make it more roller beetle and less gryphon!
-The biggest thing I enjoyed is, by far, boons being used on the enemies. The cynic in me thinks this was added to justify Spellbreaker and Scourge but now enemies are actually using boons frequently (even more than one!) it's meant boon removal skills and sigils on other characters is worth bringing. It also means that when things like protection are swinging around, power isn't going to magically override everything. Don't be scared of making more enemies have player abilities or player like abilities, it worked in GW1 and in PoF the boon applications haven't broken things. If there's one thing I want to see more from PoF in other content it's this. I really want you to push boons on enemies; have enemies pump out resistance, or even things like condition removal.
-I like 'the forged and how they have a way of controlling the environment. The walls of fire the mages spawn are mechanically interesting, since you can't just run through to the target to clobber them.
-Sand lions and scarabs are annoying with their auras. They're nearly as annoying as smokescales, but at least you can lure a smokescale out of it's stupid immune-to-damage aoe. And at least with scarabs and sand lions aoe damage can still hit them.
-Bounties are okay but outside of grinding titles or getting a specific drop you kill them and move on. The randomised properties idea is fun, and can really change things up; however, sometimes the combination just screws you over. I'm okay with that actually-it's annoying but sometimes you're the pigeon, sometimes you're the statue.
-It was fun going back to elona and seeing how things had (and perhaps more importantly, hadn't) changed.
-This is a nitpick but you asked for feedback. The area around Elona Reach area is unregonisable though to the point where I logged back into gw1 to check and there is simply no landmark I recognise. This and the temple of ascension from Dunes of Despair surprised me; with the temple, that were was suddenly a massive cliff in the way. I was expecting joko's wall, or deep sulphur pits you couldn't cross, or ocean. Not a massive cliff out of nowhere. I understand it's not the same game, but it's set in the same place so such a massive change to local geography is jarring.
-I've mentioned it elsewhere but I like how in Vabbi culture undead are... there. There's no stigma, and you can be getting nagged by your great-uncle who's been dead for ten years.
Elite Specs
-I've not played all of them, because I'm not very good (or interested) in playing some classes, or the elite specs. I'll give my thoughts on some of them though.
-Spellbreaker is fun. I enjoy how it works and it synergizes well with the other traitlines. Can't believe it took someone else to point out what Full/Revenge Counter was referencing.
-Firebrand: I like the changes to the F skills it gives, short spammable buffs. Not sure I'm going to keep using it but it's definitely different to the base class, and fun to use.
-Holosmith is enjoyable, and while I don't play my engineer much, it's got me into giving scrapper another go too, and discovering I enjoy that elite too. So yay for holosmith. The overheat mechanic is quite fun too, even being allowed to weaponise it.
-I am still convinced Deadeye's rifle gunshot sound is meant to be trolling those who wanted a 'kitten sniper'. Pew pew!
-Soulbeast was a non-starter for me. I like running around with the pet, so eating the pet for buffs got me 0 interest. Bringing this up because Druid doesn't interest me either, so the ranger elite specs have been duds for me. Better luck next time?
Meta vs hearts:
-I prefer the large meta events from HoT and parts of living story, such as the attack on Lion's Arch. It reinforces what has (to me) been perhaps the tentpole design choice for the game: player cooperation, and working together. The entire map working towards a goal with different groups in different bits is the logical conclusion of that, and pre hot I always enjoyed the maps that required you to push the metas (like Orr) and felt the maps that didn't suffered for it.
Hearts are far more 'do on your own leave on your own' and I think that's in part why HoT is still has good population numbers. It has interesting events that tell the story by playing, most players have got the (far too many) masteries done and even if you don't, the mounts from PoF make getting around far, far less painful, and people have been trained to work together on the maps. But I still haven't forgiven you for the mushroom enemies, or the chakk.
However, PoF swung to mostly-hearts-but-a-few-metas. I wasn't on the forum at the time, I'm guessing that's due to feedback from HoT. My advice is push the HoT style meta events hard-some bits for some situations might be better with a heart, however, once again I want to say I think large scale meta events is far more interesting. I still remember the trailers hyping the game up pre-release about not seeing an npc with a marker standing there with an icon over their head (cough cough). I was going to see that centaur attack happen, I was going to have to defend or retake the village. You're never going to make people happy-I know I'm frustrated when 'the' meta map is full or I miss an event or arrive too late to help, and the wheels fall off the entire thing, but that honestly makes succeeding all the sweeter imo.
@Gaile Gray.6029 said:
Please share your high-level feedback about Guild Wars 2: Path of Fire in <100 words.
Path of fire unlocks elite specializations which give players unfair advantages in PVP and travel speeds which make it impossible for regular players to keep up with event trains. This makes the expansion is the very definition of "Pay to win"
I loved GW1, GW2 pales in comparison when it comes to the writing, I still like it though. I have 2500 hours in GW1 and 1600 hours in GW2. Path of fire is a complete disappointment to me because it seems like the balthazar plot was just taken out of nowhere. and written for the sake of having a plot. Instead of just making things up why not take things from the guild wars lore already in place, and create a plot. Like for example, the wizard's tower, was a mystery in GW1 and still a mystery in GW2, and we have not heard anything about it yet. The same goes for the dominion of winds, it's "just there" we have not heard anything about it. Elona we heard that Palawa Joko conquered it, but when PoF came out he's barely even in the story.
TLDR: The story is terrible. Instead of just making new things up, why not use the already mysterious and intriguing lore that is already written and make plots that way. Like in GW1 there were so many mysterious things that we fans were interested about that did not get fleshed out. We also things in GW2 we have no idea about like the largos. And Kralkatorrik or the Elder dragons isn't even mentioned in this, well so far, i'm on the last act of the PoF story.
A bit of a request (that I'm sure it as already said before):
Allow griffons to use updrafts!
Thanks for reading
@Kitty.6219 said:
A bit of a request (that I'm sure it as already said before):
Allow griffons to use updrafts!
Thanks for reading
and what would be the point of gliders ?
Improve GW2 performance. Add genuine DX12 support.


text:
The future concept cars coming out these days are just spectacular. Sports cars are out of the range, this is the "Incepto, new design trends and styling language, Azerbaijani designer Samir Sadikhov has come up with a sports cars concept that combines luxury and performance in a single vehicle.
Incepto Sports Cars Concept by Azerbaijani Designer Samir SadikhovThe first photo is the cars in a red and black design. Hailed as "Incepto," the two-seater presents an aerodynamic body, especially the glass-covered rear wheels, to ensure minimal wind resistance and better controls at high speeds. Developed for the year 2020, the sportscar includes a dramatic center-vertical exhaust to tout an astonishing design language.
The smooth, curvy exterior of the Incepto is equally supported by an elegant and comfortable interior. Incepto Sports Cars Concept by Azerbaijani Designer Samir Sadikhov photos it is eloquent of the writer to describe the design as language. There are many medium a speaker can use to communicate. Taking the time to imagine, sketch, plan and create a concept is a very high level of communication that most think only scientists or mathematicians can reach.
Fortunately the design world is for the simplicity on this chaotic oblate sphere(Earth). Therefore all the complicated terms have no meaning for the consumer. Words that we like to hear are easy to use, comfortable, efficient, smooth and classy. The design sounds just breathtaking and so are the photos.
A concept car, designed by Samir Sadikhov, proves an amazing dexterity of a Student cum designer with a vision to build a futuristic two-seated, sporty and a luxurious sports car. He has also been able to successfully combine a enhanced aerodynamic approach by covering the rear wheels by glass and an unusual central-vertical exhaust, which is perfectly radically designed, converting his self-branded limited dream-car into a successful final product.
Though Incepto has a radical design which is different from many other designs and concept cars there is a portion of impracticality which can be refined for its better secured future.

subset: commoncrawl


text:
Public transit agencies are facing budget shortfalls and aging equipment. As transit asset managers navigate the "do more with less" environment, safety and reliability remain their top concerns.
Despite shirking budgets, the Federal Transit Administration is increasing their scrutiny of transit agencies' state of good repair practices. However, in an Accenture survey of over 100 transit asset managers, almost 40 percent stated they would need more $500 million to achieve a state of good repair and nearly 80 percent cannot meet even half of their maintenance backlog with their current funding.
While there are no quick fixes to this situation, taking an integrated approach can help address the deficit. By exploring data visualization, integrating systems, maximizing mobile opportunities, and adapting their organizational structures to be more nimble and break silos, transit agencies could begin to address their state of good repair backlogs.
Agencies will be able to have increased transparency, ultimately leading to better and more cost effective decisions if they digitize and integrate the abundance of data collected across the system. By integrating asset data with visual tools (such as geographic information systems, business intelligence software, and system dashboards) operators and maintainers can function more efficiently, and also better communicate the results and value of total asset management programs to agency leaders and the riding public.
Agencies that harness the power of mobility will be able to provide maintenance personnel with the necessary tools to improve inspections, expedite work order processing, and decrease incident response times. Furthermore mobility applications can enhance the rider experience with real-time integrated operational data and system alerts.


text:
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~~BLUETOOTH~~, ~~ONE OWNER CLEAN HISTORY REPORT~~, ~~FINAL MARKDOWN PRICE BEFORE IT GOES TO AUCTION!!~~, ~~DON'T MISS THIS DEAL!~~.31/39 City/Highway MPGAdvantage Nissan was selected as the Top and ONLY Nissan Dealer in WA with the coveted Nissan Award of Excellence along with 2014, 2015, &2016 Dealer of The Year by Dealer Rater. We are a Family owned and Operated Business Serving the greater Seattle area for over 60 Years!
A negotiable documentary service fee in an amount up to $150 may be added to the sale price or the capitalized cost of a vehicle at time of purchase.
Used vehicle pricing includes all offers and incentives. Tax Title and Tags not included in vehicle prices shown and must be paid by the purchaser. While great effort is made to ensure the accuracy of the information on this site errors do occur so please verify information with a customer service rep. This is easily done by calling us at 360-373-6300 or by visiting us at the dealership.
*For NV Cargo & NV200 Prices include Nissan Fleet Franchisee/Distributor Program and have valid business license. Contact today to determine eligibility.
**With approved credit. Terms may vary. Monthly payments are only estimates derived from the vehicle price with a month term % interest and % downpayment.
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† Based on 2017 EPA mileage ratings. Use for comparison purposes only. Your actual mileage will vary depending on how you drive and maintain your vehicle.
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Sign a lease today and get $40 off your installment monthly!
Connect with us! Text POINTE to 47464 for more info!
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Washer/Dryer in Every Unit
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Ceiling Fan in Every Bedroom
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text:
Celestia provides photo-realistic, real-time, three-dimensional viewing of the Solar System, the galaxy and the universe. It is an easy to use, freely-distributed, multi-platform, open source, software package which has become a valuable tool for astronomy education. Used in homes, schools, museums and planetariums around the world, it also is used as a visualization tool by space mission designers. Versions are available for computers running Windows, Macintosh (Mac OS X) and Linux operating systems, with mobile (iOS and Android) versions recently released.
Although it is optimized for 3D astronomical visualization, Celestia can be used to display and explore other 3D environments, too.
And, for some reason, many people seem to find exploring with Celestia to be a lot of fun.
About this guide[edit]
This Guide to Celestia is intended to be a comprehensive source of information for students, educators, and other users of Celestia. It includes instructions for obtaining, installing, using, customizing, and troubleshooting the Celestia software, as well as explanations of concepts and techniques from astronomy and computer graphics as needed to fully explore and understand Celestia and its universe. It is intended to address the needs of novice, casual, and advanced users.
The Guide to Celestia is very far from complete. You can help by adding useful content. Members of the Celestia community are encouraged to be bold in editing this WikiBook to provide the additions and corrections needed to make it useful for themselves and others. Please share your knowledge here.
Icons indicate approximate development status.
Of course, all pages are subject to improvement at any time.
Using Celestia[edit]
Currently, this section only contains basic explanations of how to use Celestia. If you would like more detail, please refer to Frank Gregorio's Celestia 1.6.1 User's Guide (also available as a PDF).
Getting Celestia to Run[edit]
Exploring Celestia's Universe[edit]
- Getting Started: some usage examples
- Locations
- Navigation
- View Control
- Time Control
- Bookmarks (cel: URLs)
- Snapshots and Movies
Understanding Celestia[edit]
Enhancing Celestia[edit]
The following reference pages will help you to add features and make Celestia easier to use in your environment.
- Scripting Overview
Customizing Celestia[edit]
- Catalog Files: Defining new Objects
- Positioning Objects: Flying through Time and Space
- Orbits & Trajectories
- Rotation Models
- Scripting Positions (some implications of scripted methods)
- Keeping up Appearances
- Specifying the Correct Time: TDB is not UTC
- Celestia/Troubleshooting Celestia
- Troubleshooting Scripts
- CELX Development Suggestions: tips for improving your CELX/Lua scripts.
- Development: Compiling Celestia for yourself
- Development Road Map: Planned improvements and new features.
- Features being considered for v1.6.0
- 1.6.0 Changes for SSC/STC/DSC files
- 1.7.0 Changes: WIP list of changes in Celestia 1.7.0
- Versions: Major Celestia milestones.
- Bugs and Feature Requests
- Internationalization (Celestia i18n): Contributing to the translation of Celestia
Addon Tutorials for Beginners[edit]
The following pages are for beginners. These are tutorials for creating different kinds of celestial bodies in Celestia.
- Tutorials: a few things you should know before making addons for Celestia.
1. Creating Solar System Objects
- Asteroids (basic): Adding simple asteroids to Celestia.
- Comets: Adding comets to Celestia.
- Asteroids (advanced): More advanced aspects of asteroid-making in Celestia.
- Moons: Adding natural satellites around objects in Celestia.
- Near-Earth Asteroids: Making asteroids whose orbits get perturbed in Celestia.
2. Creating Extrasolar Objects
- Stars: Adding stars to Celestia.
- Star Systems: Adding binary stars and multiple star systems to Celestia.
- Exoplanets: Adding exoplanets to Celestia.
3. Creating Deep-Sky Objects
- Acknowledgements: Contributors to Celestia and to this WikiBook.
External links[edit]
Related Wikibooks[edit]
- A-level Physics/Cosmology
- Astrodynamics
- Astronomy
- Glossary of Astronomical Terms
- Solar System
- Wikijunior:Solar System
- Introduction to Astrophysics
- Transformative Applications in Education/Celestia
- The Universe Made Simple
Celestia Web Sites[edit]
- https://celestia.space/ - Home of Celestia
- https://github.com/CelestiaProject/Celestia - Celestia binaries and source code
- https://celestia.space/forum/ - Celestia Discussion Forum
- https://www.classe.cornell.edu/~seb/celestia/ - Selden's List of Resources for Celestia
- https://de.wikipedia.org/wiki/Celestia - German wikipedia
- https://fr.wikipedia.org/wiki/Celestia - French wikipedia
- https://fr.wikibooks.org/wiki/Celestia - French WikiBook
- https://www.jcvignoli.com/celestia/wiki/index.php/Accueil - French Celestia Wiki
- http://celestia.albacete.org/ - Web page with a lot of activities (Spanish)
Celestia Add-ons[edit]
- http://www.celestiamotherlode.net/ - The main add-ons repository
- http://www.celestialmatters.org/ - Celestial Matters web site: Celestia add-ons and other content of interest to Celestia users
- http://forum.celestialmatters.org/index.php - Celestial Matters forum
- https://www.jcvignoli.com/celestia/ - French repository of add-ons with eMule links --old
- http://www.celestiamotherlode.net/catalog/educational.php - A website containing detailed Celestia educational resources and journeys
- http://forum.celestialmatters.org/viewforum.php?f=6 - Celestial Matters - F-TexTools and refereed Add-ons
Articles about Celestia[edit]
- http://www.linuxjournal.com/content/exploring-space-celestia - Linux Journal article Exploring Space with Celestia by Mike Diehl, July 15, 2008.
- http://www.linux-magazine.com/issue/58/Celestia_3D_Space_Simulation.pdf - Linux magazine article Touring the galaxy with Celestia STAR JOURNEY by Kristian Kissling, Issue 58, September, 2005.
- http://web.archive.org/web/20051224085847/http://www.esa.int/gsp/ACT/mission_analysis/designtool_overview.htm - ESA Advanced Concepts Team overview of design tools, 2005.
- http://discovermagazine.com/2004/nov/emerging-technology/ - Discover magazine article Emerging Technology by Steven Johnson, September, 2004.
- http://www.tiempolibresite.com/content/view/482/2/ - Interview of Chris Laurel by TiempoLibreSite


text:
PORTLAND, Maine — The day after leaving office following an eight-year stint as Maine's governor, Angus King hit the road.
For the next 5½ months, King, his wife and their two children lived together in a 40-foot RV, driving 15,000 miles and traveling through 33 states.
The journey was King's way of making the shift from being "The Man" with a staff, constant press attention and 24-hour-a-day police protection to being "simply a man," he writes in his new book, "Governor's Travels: How I Left Politics, Learned to Back Up a Bus, and Found America." The book will be on bookstore shelves in mid-July.
"The trip turned out to be the perfect transition from a job like governor because it was utterly different from what I had been doing, but it was still engaging," King told The Associated Press. "I didn't go from the intensity of being governor to sitting in a rocking chair and reading a newspaper. I went to something that was very engaging. But instead of worrying about the Legislature, I was worrying about whether the next RV park had a dump station."
King was elected governor as an independent in 1994, his first run for public office, and was re-elected in a landslide in 1998. Prohibited by law from running for a third term, he left office in January 2003.
He and his wife decided to buy a motor home equipped with all the comforts of home, take 12-year-old Ben and 9-year-old Molly out of school and embark on an extended, leisurely trip with no specific itinerary. King kept a log during their travels, which he then took to Down East Books.
The result is a 160-page book that chronicles the voyage, which took them from Maine to Florida, then west through the southern states to California, north to the Pacific Northwest and back east through the northern states and Canada.
The book drives home the themes of transition, family and travel, King said, while encouraging people to live their dream.
"It's amazing the number of people I talk to who get kind of misty about the idea of traveling across the county with their family," King said. "Either they did it as a kid, they knew someone who had done it or they always want to do it. It seems to be a fantasy many Americans have, and part of the purpose of the books is to encourage people to do it. If I can learn to back up a bus, believe me, anybody can."
The book will be distributed nationally, said editor Michael Steere.
King, 67, said he's also going to the Family Motor Coach Association's annual convention in August in Madison, Wis., where he'll present a slide show and try to sell a few books.
"It's a fun book," he said. "This isn't going to replace 'Look Homeward, Angel' in high school literature classes, but I hope people will enjoy it from the perspective of travel and RV-ing."


text:
Auto Publishers Price Starting at
*Based on model year EPA mileage ratings. Use for comparison purposes only. Your atual mileage will vary, depending on how you drive and maintain your vehicle, driving conditions, battery pack age/condition (hybrid only) and other factors.VIEW OUR INVENTORY
Powerful engine selections; sharp styling inside and out; available all-wheel drive
The GMC Terrain receives several changes for 2016. Trims now include SL, SLE-1 and SLE-2, SLT and Denali. The front and rear fascias are restyled, with a new grille design for SLE, SLT and Denali trims. LED daytime running are standard on top trims, the center instrument stack is revised, an eight-way power-adjustable passenger seat is offered on the SLT, and available safety technologies on SLE and SLT include blind-spot alert and rear cross traffic alert.


text:
wet okole seat covers
Reviewed By Chaz M (Twin Falls, ID) Reviewed for a 2007 Subaru Impreza —6/15/2013 8:34 PM
Love the seat covers! Not too bad to install, and look great. If the car sits in the sun the smell of adhesive gets kind of over powering, and they get kind of hot after sitting in them for a bit.


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Questions? Ask in the Community Forum.
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Frequently Asked Questions
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Community content is available under CC-BY-SA unless otherwise noted.


text: Have you hugged your foot today? Created by Tinker Hatfield during his hot streak of sneaker design for Nike during the late 1980s and early '90s, the landmark Huarache technology is intended to offer a lightweight, foot-hugging feel. This is achieved by the use of stretchy neoprene material in a bootie design around your foot and ankle, which Tinker was inspired to use after noticing how the inserts for water skis securely and comfortably held your feet in place. Huarache tech debuted in the Nike Air Huarache runner and Air Flight Huarache basketball shoe in 1991, and has since been utilized across virtually all Nike categories from cross-training, to soccer, to modern lifestyle sneakers. Nike Huaraches have become a mainstay in the brand's casual line, with the Air Huarache right up there with always-in-production greats like the Air Max 1 and Air Max 90. Simply put, your sneaker collection can't quite be complete without a pair of Huaraches.


text:
Namayiana is an informal cooperative of Maasai women artisans who create traditional Maasai beaded items. Namayiana means "We are blessed" in Maasai. When asked how long the Maasai have been doing beadwork they answer, "Since the first Maasai was born." These Maasai artisans live about an hour from Nairobi in the Ngong Hills. Namayiana has provided many benefits to the more than 100 families involved. Income from craft sales has helped to provide food, clothing and school fees for the artisans' families. The women work independently for Namayiana, both at home and at the workshop.
Namayiana was founded in 1990 when two Maasai handicraft groups merged. The group was initially sponsored by Mennonite Central Committee Kenya, and is now independent. Ten Thousand Villages has purchased products from Namayiana since 2001.


text:
New Year, new 'do!
With less than two weeks until 2013, Kim Kardashian touched down at LAX on Tuesday Dec. 18 with a fresh new look: Sexy, side-swept bangs and a few inches off of her overall length. "There's no place like home! I'm soooo tied! Finally a day off tomorrow! Can't wait to sleep in, in my very own bed!" Kardashian tweeted of her arrival back from Miami; she appeared fresh-faced, with minimal makeup, at LAX.
PHOTOS: Kim's best hairstyles ever
The man responsible for the 32-year-old reality superstar's sexy, trendy new look: Celeb hairstylist Chris McMillan.
"Fun shoot today @mrchrismcmillan He just can't control his scissor hands! #bangs'," Kanye West's love tweeted beneath several instagram shots of the haircutting process.
McMillan, who famously gave Jennifer Aniston her iconic "Rachel" haircut back in the Friends era — and gave Miley Cyrus her shocking blonde, punk pixie cut earlier this year — also chronicled Kardashian's makeover.
"shawnsssr BANGS!!! @kimkardashian #love #fringe #photoshoot #sexy @ Pier 59 Studios,'" he wrote.
Tell Us: What do you think of Kardashian's new do?
For access to all our exclusive celebrity videos and interviews – Subscribe on YouTube!


text:
Richland Farms | KCET
Several years ago, a group of migrant farmers from Mexico and Central America took over an empty lot in South Central Los Angeles and created a community garden that became a model for urban agriculture. These farmers started out with one basic goal -- feed their families as economically as possible using knowledge and practices brought with them from the agrarian roots of Central America. Real estate disputes in 2006, however, put an end to the community garden, and the farmers were evicted from the land.
Similar to the struggles of the South Central farmers, the land and history of Compton's Richland Farms can provide a new springboard for community-based environmental practices.
We explore the land and history of Richland Farms, while taking a look back at the forms of informal urban agriculture practiced by the area's black residents during the 1950s and '60s. The story also traces the practices that were lost and then recovered by Latinos migrating from Central America, and ask what lessons they may provide for creating models of urban agriculture for future generations.


text:
Frequent and periodic database updates enabling dynamic data for accurate risk ratings.
Alignment of geographic ratings with over 70 financial institutions globally including broker dealers and several large banks using a tested methodology.
Reduced time spent on generating ratings and reviewing the results leading to more time for focusing on risk mitigation rather than risk assessment.
IBM enables companies to scale and adapt quickly to changing business needs without compromising security, privacy or risk levels when using IBM cloud offerings.Learn more about IBM Cloud security


text:
A few years back, we published a series of seven books called Guides to New Testament Exegesis. The seven titles are also available individually (links below go to individual volumes), but of course you save by purchasing the collection:
- Introducing New Testament Interpretation by Scot McKnight
- Interpreting the Synoptic Gospels by Scot McKnight
- Interpreting the Gospel of John by Gary M. Burge
- Interpreting the Book of Acts by Walter L. Liefeld
- Interpreting the Pauline Epistles by Thomas R. Schreiner
- Interpreting the Epistle to the Hebrews by Andrew H. Trotter Jr.
- Interpreting the Book of Revelation by J. Ramsey Michaels
These books provide a general introduction (by Scot McKnight, no less!) to the interpretation of the New Testament, as well as genre-specific methods and materials for doing exegesis. One thing I didn't know (but learned from reading the product page on Logos.com — good stuff there!) was that:
The vision for this collection comes from Gordon Fee's New Testament Exegesis: A Handbook for Students and Pastors. By developing handbooks for each genre and book collection, this collection operates as an extended treatment of Fee's narrower scope.
Fee's work is detailed and valuable; to have his methodology distilled and applied to these particular genres is a helpful thing. It's like getting a jump start in New Testament exegesis. And to have it done by folks of the caliber of Scot McKnight, Thomas Schreiner, and Gary Burge? Even better. Check it out.
Speaking of New Testament exegesis, another title that you might find helpful is Donald Hagner's introduction, New Testament Exegesis and Research: A Guide for Seminarians. This is geared toward seminarians, but helpful for everyone. If I understand correctly how the book came about, it is basically the information that Hagner gives incoming seminarians, to get them properly grounded at the start of their seminary career.
Need some more suggestions? I'm out of room here, but you might try I. Howard Marshall's New Testament Interpretation, David Alan Black's Interpreting the New Testament, or perhaps even Katharine Barnwell's Linguistics and New Testament Interpretation. Check 'em out!


text:
Product Description
Fits Round Patio Table or Set up to 94W x 23H (inch): Heavy Duty polyester exterior with waterproof inner layer makes Savanna Covers a top choice for all season protection. Attractive two tone colour provides a premium look to your outdoor setting. Comes with adjustable elastic hem cord, airvents for needed air circulation, handles for easy removal, strap and buckle to secure in windy conditions.


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Cctv cameras Meyerton best CCTV Suppliers in Meyerton, best CCTV Cameras in Meyerton, best CCTV Installations Meyerton
CCTV Cameras Meyerton are ready to assist you with all your CCTV Camera Needs. Whether you need new CCTV Cameras installed, repairs or maintained we are here to help you. We supply all the well known brands of CCTV Cameras and have all the latest technology CCTV Cameras. We provide full training to all our CCTV Technicians as we know technology is always growing so we need to be up to date with all the latest CCTV Cameras. We aim at providing professional service at all times and that we are able to answer any questions that you may have regarding CCTV Cameras. All out clients have been very satisfied with the service that we provide. CCTV Cameras are becoming very popular and also a much need for security purposes. We offer the best quality CCTV Cameras and CCTV Cameras to suite your needs and budget. We always have our client's needs taken care of and we make sure we understand exactly what they are looking for.
CCTV Cameras Meyerton have been in the CCTV industry for over 35 years and have always kept up to date with all the latest technologies such as wireless cameras which we also supply. We are also able to connect the cameras to your smart phone allowing you to view your premises even when you are not there. Each Job that we dot we do it to our best ability and we will never not leave job uncompleted or leave our clients unsatisfied. Our workmanship is guaranteed and we promise that you will not be disappointed in the service that we offer. For all your CCTV Camera Installation, repairs and maintenance contact CCTV Cameras Meyerton today.


text:
As part of our outreach and education commitment, the AAVSO provides a list of prepared PowerPoint presentations written by AAVSO members, intended for you to use in a talk or presentation about variable stars and how to study them. These presentations cover a wide range of topics: from Variable Star Observing Techniques to Dark Sky Preservation to CCD Photometry Techniques. Intended audiences range from general public to advanced astronomy meetings.
We invite submissions to the listing of available PowerPoint presentations. Each presentation must meet the following criteria:
1. Each slide must be annotated with text as would be provided by a speaker when appropriate.
2. The presentation must be of your own original work. Any images, graphs, quotes, etc. in the presentation, if not the author's, must give proper acknowledgement to the actual owner of the work.
3. The PowerPoint presentation must be compatible with PowerPoint v.97 and later.


text:
With Comcast upping its speeds to 50Mbps in a few markets, Verizon's gotta roll out a big, round number to compete, so they've announced, and then hedged, the upcoming rollout of 100Mbps FiOS service, starting hopefully in 2009.
Verizon technology director Vincent O'Byrne declared 2009 the year America finally breaks the 100Mbps barrier that Hong Kongers have, well, long since passed. O'Byrne was quick to note that the bump in speed isn't really essential to most Verizon customers, but that the number represents more of a marketing milestone that could give them a one-up on chief competitor Comcast.
Later, a Verizon spokesperson contacted Telephony Online, the original reporter, to perform some spectacular hedging: "Verizon expects to have its delivery processes for speeds like that locked down in 2009 so that service with speeds approaching 100 Mb/s would be enabled in the very near future," the spokesperson said. So Verizon is going to hit that landmark 100Mbps soon, but it appears for now there's no guarantee. No pricing was made available, either, although the current fastest tier, at 50Mbps, costs $US145 without bundled phone service. [DSL Reports]


text:
Tag Archives: Ashes
FWA Q&A: TIM RICHTIM RICH of The Independent on heroin and incest...interviewing the wrong Kanoute...and a fabulous lunch in the occupied territories
Have you ever worked in a profession other than football?
I once ran a campsite in France and once worked, very inefficiently, filling bottles of shampoo at a factory where all work stopped for 10 minutes to listen to Simon Bates' Our Tune.
Tags: 2005 European Cup Final, AC Milan, Africa Cup of Nations, Allianz Arena, Andorra, Ashes, Bangkok, Brazil, Chelsea, Frank Keating, John Bercow, Kanoute, liverpool, Martin Blackburn, Neil Custis, Real Madrid, Rory Smith, sir bobby robson, St James' Park, Steven Gerrard, Sunderland Echo, The Independent, Zinedine Zidane


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If the bread contains a ribbon of creamy almond paste it is called a "stol". If it doesn't, it's "just" Christmas bread. During the December holidays, buttered slices of kerststol will be part of breakfast or brunch and may be offered to guests instead of a cookie with their cup of coffee or tea.
The stores and bakers will sell exactly the same bread at Easter, but then it's called paasstol.
The commercially prepared stollen are heavy, chewy and rather rich. I prefer mine a little lighter so I use all purpose flour instead of bread flour.
1/2 cup of golden raisins
1/2 cup of candied peel (orange, lemon, citron)
1/4 cup of orange juice
2 1/2 cups of all purpose flour
1/2 cup of milk, warm
2 teaspoons of active dry yeast
1/4 cup of sugar
1/2 teaspoon salt
1 egg, beaten
1/2 stick of butter, melted
1/2 teaspoon lemon zest
1 small can of almond paste* (or make your own by blending 8 ounces of sliced almonds with the same amount of powdered sugar, an egg, a teaspoon of zest and a teaspoon of almond flavoring)
2 tablespoons of butter, melted
2 tablespoons of powdered sugar
Combine the raisins and the candied fruit and soak in the orange juice, preferably overnight but at least for a good four hours.
In a large bowl, place the flour. Make a well in the center and pour the warm milk in, and sprinkle the yeast on top. Let it sit for five minutes. This is a great time to pour the soaking fruits in a colander or sieve so they can drain. Stir the flour and the milk until it barely comes together. Add the sugar and the salt, stir again, and slowly add the egg, then the melted butter and the lemon zest. Continue to knead for five or six minutes or until the dough comes together. If it's too dry add a tablespoon of milk at a time.
Give those raisins a quick squeeze to drain some superfluous liquid. Fold these into the dough: either by hand or in your bread mixer, but be careful that you don't tear through the gluten strands! You'll probably have more dried fruit than you think will ever fit, but keep kneading and pushing those raisins back in the dough (they tend to escape). Knead the dough carefully until the raisins and candy peel are well distributed. Grease a bowl, place the dough inside, cover and rest for an hour at room temperature or until the dough has doubled in size. Don't skip this step as the stol will be very thick and heavy if you do.
Gently deflate the dough and pat into an oval. Place the oval with the short end toward you and make an indentation along the length of the dough, in the middle. Now roll the almond paste on the counter until it forms a roll almost as long as the dough. Lay the almond roll in the indentation and lift the left side of the dough over the paste. Make sure that the dough does not meet the bottom half all the way: a significant shape of the stol is the bottom "pouting" lip of the bread. If you want a more pronounced pout, fold the right side of the dough one-third towards the almond paste ribbon, and fold the left side of the dough in half, placing it on top of the bottom half and covering the paste.
Rest the dough on a lightly greased baking sheet or silicone mat. Cover it and let it proof for about 30 minutes or until ready to bake: the dough should barely spring back if you poke it with your finger. In the meantime, preheat your oven to 350F. Bake the bread for 40 minutes on the middle rack, then reduce the heat down to 325F. Brush with melted butter and bake for another five minutes, then brush again and bake for another 5 minutes. If the bread is browning too fast, cover it with a piece of aluminum foil. Use a digital thermometer to determine if the bread is done: the temperature should be 190F and rising.
Cool the bread on a cooling rack. Sprinkle with powdered sugar and slice.
Tip: If you have any kerststol left over the next day, toast a slice until nice and golden. Whip the almond paste out with the tip of your knife and spread it on the warm slice of bread. Yummm!!!!!!!!!


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Hard to believe we've been camped in Gail/Dan's driveway for over a week. Is it remotely possible that we've overstayed our welcome? Um, yes.
But, what a terrific family holiday we've had. We arrived on Christmas Eve afternoon, about 10 minutes behind my sister Lynn and husband Jerry, who traveled from Green Valley, AZ. We tucked the Fireball in behind Gail and Dan's coach. It was intimidating enough that we slept with one eye open every night!Gail's son Mark, along with his wife Tatsumi, and kids Erin and Shaw rolled in from Laguna Hills, CA on the 26th to complete the holiday celebration. This is our whole gang – Lynn/Jerry, Gail/Dan, Tatsumi/Mark, Shaw, Erin, John and me. Jezzy sneaked into the photo, although the other five pups somehow were left out. Gail/Dan bought everybody remote controlled helicopters for Christmas. An aerospace engineering degree apparently didn't help Mark much with his launch. Who knew these would be so difficult to fly?John also a tough run with his mini-helicopter, managing to fly it into the light fixture over the dining room table, delighting the peanut gallery, and terrorizing all the dogs.
We did get in a bit of a hike at Red Rock Canyon National Park (sans Gail and Dan), despite frigid temps and high winds, over unenthusiastic protests of teenagers Erin and Shaw. We scrambled over boulders and through narrow crevices on a clear, cold day, and enjoyed the spectacular scenery (in spite of ourselves). Here's Mark, Tatsumi, and Erin. Tatsumi gave us a real Cheryl Strayed moment when she slipped out of her shoe while scrambling over some slickrock. Fortunately, her shoe tumbled down onto John, who snagged it as it rolled past. It was a photo-perfect afternoon, highlighted by the appearance of four wild burros, sighted shortly after we drove into the scenic drive. Although we know they are in the area, this is the first time we've even seen them – what a treat! We kept our distance, so this photo is somewhat less than National Geographic quality.t Much of the rest of our time was spent playing games (I may be the family cribbage champ, although Gail and Mark tried hard). Have you ever played Dumb Ass? A crazy fun board game with lots of laughs. Perhaps the weirdest game was Heads Up, which utilized an iphone. It was ridiculous, separating the generations among us even more quickly than Name That Tune could have done.
While Mark and Shaw played dominos, Erin created a beautiful pagoda with the spare bones. She casually created what the rest of us could not have done with an instruction diagram. Thank you, Shaw and Erin for hanging in there with us – I can't imagine myself being quite so gracious as a young teen hanging out with my great aunts and uncles.
Mark, Tats, and kids rolled away on Monday, Lynn and Jerry on Tuesday. So, we decided to gorge on sushi on Tuesday night. One of the most enjoyable feasts we've had. Our Fireball refrigeration has crapped out again (for the last time). We're junking this fridge, but have decided to go without any electronic refrigeration for the next month, while we camp. Just too much hassle (and expense) to get one shipped in to Vegas, so that we can install it while we are still here. Does that qualify as roughing it? Doubtful!
Jezzy and I have patrolled the area since we've been here, trying to make up for the three lost days of activity while we were in transit. Here's my activity log from my Garmin Vivofit for December. I purchased it on December 4 – can you tell which were our three travel days? Not too bad for 27 days!
John and I took the bus down to the strip on December 31 (afternoon) to check out the decorations at the Bellagio. Stunning. Unfortunately, there were too many people, and I have too little patience to have anything to show for the day. But, the gawk-worthy Chihuly ceiling there did merit a photo.Taking the bus was a blast, but it did account for a big portion of my mileage for the day (about 10.5 miles). We waited patiently at one stop, after running out of energy to push ahead on foot.The oddities of Vegas, and especially Gail's neighborhood will never get old for me. We awakened every morning (around 3am) to the rooster that her neighbors keep in their back yard. Apparently, they also brought in some turkeys (at least one of whom escaped the Thanksgiving axe). It's a bit unnerving to hang out in the back yard, and hear a turkey next door – although we never got a glimpse of him because of the wall between. The house around the corner has two horses in the yard. It's wild and woolly in their unincorporated neighborhood.
Christmas decorations without snow will always be an oddity to me. These strings of lights, laid right on the roof would never last in Michigan.Palm trees?But, now it's time to camp! Tomorrow at this time, we'll be in Lake Havasu State Park. That's our first stop in a month-long trek around the perimeter of AZ, traveling along the west, south, and east borders. All of our destinations are campgrounds we've never visited, and we're excited to cycle new roads, and hike new trails.
So, bye to Gail and Dan (for now). They'll be heading to Green Valley in February, staying just yards from Lynn/Jerry, and a few miles from our rented house in the area. For now, we're shedding no tears at parting.
We did finish out our year with 179 days of living in our T@DA. Not sure if we can outdo that in 2015, but we will dream about it.
Happy New Year to all. Hope there are adventures in your future!


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Las Vegas, NV -- Representatives from dozens of national and state-based equine protection, advocacy and rescue organizations gathered April 9 and April 10 at Bally's Las Vegas for the third annual Homes for Horses Coalition Conference to discuss the re-homing of at-risk horses in America and other equine welfare concerns.
The conference was held in conjunction with The Humane Society of the United States' Animal Care Expo, which included two equine welfare workshops on Wednesday, April 8. Immediately following Homes for Horses 2009, coalition member Best Friends Animal Society hosted an "Equine Sanctuary Basics" workshop April 11 and April 12 at Best Friends Horse Haven in Kanab, Utah.
"The equine rescue community in the United States is hard at work every day to provide care and futures for America's homeless horses, and the Homes for Horses Coalition helps this community to excel in its mission" said Keith Dane, The HSUS' director of equine protection. "Coalition members attending this conference were provided with many ideas and tools that will enable them to ensure that every horse has a home, and no horse must ever endure neglect, abandonment or the horrors of being sent to slaughter."
Formed in 2007, The Homes for Horses Coalition is dedicated to ending horse slaughter and other forms of equine abuse while promoting growth, collaboration and professionalism in the equine rescue and protection community. Sponsored by the Animal Welfare Institute and The HSUS, the conference featured a wide range of equine protection issues including: innovative programs for re-homing at-risk horses; fundraising strategies; community outreach; emergency preparedness and a new accreditation program for equine rescues and sanctuaries.
"This year's conference truly marked a turning point for the equine welfare community", said Liz Ross, the Animal Welfare Institute's federal policy advisor. "With the announcement of a forthcoming accreditation program for equine rescues and sanctuaries and wide participation from a diverse range of groups, we are moving towards an increased level of professionalism and wider reach in our work to aid at-risk horses."
The Homes for Horses coalition member organizations represent a wide array of equine welfare organizations including equine rescues, sanctuaries and retirement homes, as well as programs that work directly with children, law enforcement and community groups to provide second careers for at-risk horses. All of the coalition's members are active supporters of The Prevention of Equine Cruelty Act of 2009 (H.R. 503/S727), which, when passed, will prohibit the slaughter of horses for human consumption in the U.S. and the export of American horses for slaughter. To learn more about the coalition, please visit: homesforhorses.org.
The Animal Welfare Institute, founded in 1951, is a non-profit organization dedicated to reducing the sum total of pain and fear inflicted on animals by humans. AWI's government and legal affairs division is leading the national campaign to end horse slaughter and advocating passage of the Prevention of Equine Cruelty Act. For more information, please visit www.awionline.org.
The Humane Society of the United States is the nation's largest animal protection organization — backed by 11 million Americans, or one of every 28. For more than a half-century, The HSUS has been fighting for the protection of all animals through advocacy, education and hands-on programs. Celebrating animals and confronting cruelty — On the web at humanesociety.org.


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Amazon Global Store provides customers access to international brands and imported products on Amazon. The selection currently contains items shipping from the United States.
Products sold through Amazon Global Store are made available for purchase to you. You can pay for these products in Arab Emirates Dirham (AED) using payment methods such as credit cards and Cash on Delivery (COD). When you search for a product of your choice using the search bar, the search results displayed will contain imported Amazon Global Store products along with other similar products offered by local sellers. To refine your search to display only Global Store products, select Amazon Global Store US in the left navigation pane on web or under Filter on mobile.
The prices displayed for Amazon Global Store products include the import fees and taxes deposit (IFD) for importing the product into the UAE. The applicable IFD and shipping charges will be displayed during the checkout process so you can review the same before placing your order.
The prices for all Amazon Global Store products on Amazon.ae are amounts converted from USD to AED on a daily basis.
Expedited Shipping rates are estimated below the item price. Learn more About Global Store Shipping Rates & Times.


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Is anything more boring than a guitar solo? For every exquisite blues jam from Hendrix or Page there's a million, billion widdley-widdley space-filling show-offs getting in the way of the next chorus. They have their place, and that place is 1974... unless you're The Wave Pictures' Dave Tattersall. He's not Eddie van Halen or Randy Rhodes, he's better - technically he's all over the shop, but that's not the point. He writes such beautiful and expressive parts, so messy and impassioned you could listen to him play forever. Which is a good thing, because City Forgiveness, the Leicester trio's twelfth(ish) album is a double: 20 tracks, 90 minutes. That's a lot of Wave Pictures to take in.
But then this is a band that have never stuck to convention. They're about the most 'indie' indie band on the planet - they couldn't be more indie if they lived with Steve Lamacq under a poster of Morrissey in a club called 'Smashing' and existed on a diet of cider and old Helen Love fanzines. And there's things bands like that just aren't allowed to do: double albums are quite near the top of that list, followed by lengthy guitar solos and careers that seem to go on forever. They're giving it a good go though.
By now The Wave Pictures have pretty firmly set their stall out. They create bright, brittle pop and woozy, warm ballads, recorded with a cosy, sessiony analogue feel. The lyrics are witty and brilliant, the chemistry between the trio palpable, and the musicianship intricate without being showy. City Forgiveness doesn't mess with the formula, but does let the band spread out a little. The jams feel longer and more indulgent, that's true, but they also feel completely natural. Even the six-minute-plus 'The Yellow Roses' never feels like it's outstaying its welcome, as it spirals and shuffles through a dark, Sixties blues. 'New Skin', one of the more sombre moments here is allowed to build slowly, reflecting the lyrics' feel of gradual healing through, it has to be said, a fair dollop of misery, "I am a whippet now, I am alarmingly thin" sings Tattersall, "I was born on the head of a pin, but I think I just grew another layer of skin". Elsewhere 'Golden Syrup' is amongst the most stripped down and acoustic the band have been, a ramshackle strum bringing to mind the La's.
There's some great pop moments here too. 'Before This Day' forms around a spidery, Africa-inflected guitar figure, with Tattersall painting a picture of domestic life where "Mum steadies the ladder with a slippered foot" while "the neighbours' cat is white and insane, collarless aggressive and unnamed". Meanwhile 'Chestnut' digs into a growly blues riff, ("Soapy bubbles on my face / I look just Father Christmas" sings Tattersall.) It's ace.
There's not a duff track here, yet something does feel a little off - it surely ultimately comes down to the length. Putting it bluntly this is two albums, not one. And those two albums sounds really similar. It's immensely hard to pull off a double album - it needs to flow and move, and peak and trough. While City Forgiveness does allow the trio breathing room, they never use that space to justify the length - they're doing what they do, and doing it well, but the over-familiarity when faced with 90 minutes of this stuff does great songs a disservice.
7Marc Burrows's Score


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Assistance is provided on an individual and/or small group basis to any student attending Anoka Technical College. Tutored subjects in the Writing Center include all courses taught at Anoka Technical College that involve writing activities, with a special emphasis in English Composition courses.
The Writing Tutors are located in the Writing Center, Room 130. Walk-ins are welcome, appointments are available as well. Hours of operation are posted in the Writing Center.
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text: We all live on a pale, blue dot spinning in space. Blue. . . atmosphere. . . water. I explore the DNA and proteins of archaeological fish bones to understand what happened in the past under the blue surface of the water in order to better understand the lives of those in the past and the future of our present oceans. I also am starting up a holistic outreach project called Fish 'n Ships which focuses on connecting modern fishing and food, historical fishing and food, and aquatic ecology (picture below from our opening event). Today though, I am at a conference: Marie Sktodowsha-Curie Actions (MSCA) ESOF satellite event 'Research and Society' because my funding for my job in BioArCh at the University of York comes from MSCA.


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- Alzforum Recommends
Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5820-5. PubMed.
Please login to recommend the paper.
RNAi Therapy Works in Animal Models
Scott Harper et al. recently demonstrated that RNA interference (RNAi) can treat Huntington disease in an animal model (Harper et al., 2005). This work, together with a previous published experiment from the same group on treatment of spinal cerebellar ataxia (Xia et al., 2004), and two other experiments on treatment of ALS (Ralph et al., 2005; Raoul et al., 2005), demonstrates the concept of RNAi therapy for neurodegenerative diseases.
The common approach in these experiments was to deliver RNAi using viral vectors. All showed in vivo knockdown of the target gene and phenotypic improvement. These are very encouraging developments that bring RNAi one step closer to clinical application. Here I provide some background about these experiments and discuss some challenges that we still need to meet in order to realize the full therapeutic potential of RNAi.
In general, genetic disorders can be caused by two types of genetic mutations. One causes the gene to lose its function and the other causes the gene to gain a function—the gain could be either a novel function or an enhancement of an existing function. The treatment strategy for the loss-of-function type of mutations is to deliver to the patient a normal copy of the mutated gene so that its function can be replaced. But for a long time the conceptual framework for treatment of gain-of-function mutations was less obvious. However, RNAi has provided a conceptual basis for this kind of treatment (see ARF Live Discussion).
RNAi is a cellular function that is widely conserved in eukaryotes. Triggered by double-stranded RNA (dsRNA), RNAi destroys the target RNA that shares sequence homology with the dsRNA. The mechanism of RNAi is not understood completely, but a key executor is a protein complex called RNA-induced silencing complex, or RISC, which contains proteins and a single-stranded RNA (guide strand) derived from the dsRNA that the cells are originally exposed to. This guide strand is capable of recognizing the target RNA by Watson-Crick base pairing. After the pairing, RISC cleaves the target RNA. Thus, RNAi can destroy the target RNA specifically. When the target is an mRNA, RNAi can selectively knock down the expression of the target protein (Tomari and Zamore, 2005). This makes RNAi ideal for treatment of diseases caused by gain-of-function type of genetic mutations (see ARF Live Discussion).
A serious challenge to the success of RNAi therapy is the delivery of RNAi in vivo. Authors of the above four papers met this challenge by demonstrating that viral vector-delivered RNAi can treat neurodegenerative diseases in animal models. These experiments used viral vectors that express short hairpin RNA (shRNA) that can be processed to short RNA duplexes called small interfering RNA (siRNA) (Shi, 2003). The siRNAs mediated RNAi against mutant ataxin-1, SOD1, and huntingtin mRNAs, which cause spinal cerebellar ataxia 1 (SCA-1), amyotrophic lateral sclerosis (ALS) and Huntington disease, respectively. These successes are not surprising since all of these diseases are caused by gain-of-function gene mutations. Although the nature of the gained function is not clear, it is clear that disease severity correlates with the levels of mutant protein. Therefore, lowering the mutant protein levels will protect neurons from the toxic effects of these proteins.
What are the future challenges in developing RNAi therapy? Here I raise a few: First, how long is shRNA expressed after the viral delivery and to what extent and for how long is the target gene silenced? These questions have not been answered in these experiments. Therefore, it is not clear whether the observed therapeutic effects are a result of transient silencing or a sustained silencing of the target genes. A related question is, what is the best time to administer the RNAi therapy, before or after the disease onset? In all experiments the RNAi therapy was administered before the disease onset. It will be important to determine whether, by administration of RNAi therapy after the onset of the disease, the disease can be reversed.
Next, as a general rule, is it necessary to administer mutant-allele-specific RNAi? In these four cases the siRNAs were not specifically designed to silence the mutant gene because the mutant genes are human transgenes that differ in sequences from the mouse endogenous genes. Silencing the transgenes does not affect expression of endogenous mouse proteins. In human patients, however, shRNAs would silence both the mutant and the wild-type gene expression. This may be problematic because the wild-type functions of these genes are necessary for normal cellular function, and animal experiments show that in some cases they are essential (Cattaneo et al., 2001; Ding et al., 2003). In humans, the phenotypes for lack of these genes are not known, but they could be serious, given the animal data. To overcome this problem, allele-specific silencing or RNAi with replacement gene therapy may be necessary (Ding et al., 2003; Miller et al., 2003; Xia et al., 2005).
Third, are the viral vectors the best way for delivery of RNAi therapy? Delivery using viral vectors carries risks associated with gene therapy (Kimmelman, 2005). An alternative is to deliver siRNA directly to patients. A recent study has demonstrated that chemically modified siRNAs can be systemically administered and can knock down specific genes in multiple tissues (Soutschek et al., 2004; see ARF related news story). However, siRNAs with chemical modifications that allow the siRNA to penetrate the blood-brain barrier have not been reported. Nevertheless, siRNA or chemically modified siRNA may be directly delivered to the CNS to induce specific knockdown (Thakker et al., 2004). Direct delivery to the CNS does carry disadvantages, such as risks and costs associated with surgery and constant consumption of drugs. Long-term risks of toxicity with chronic administration of siRNA or chemically modified siRNA are yet to be determined.
In conclusion, the new results are exciting, and they are the first steps toward developing RNAi therapy. There is little doubt that most, if not all, mammalian cells possess the RNAi mechanism. The key to therapy rests on the development of highly efficient and safe delivery methods. If this can be achieved, RNAi can not only be used to treat genetic disorders that are caused by dominant, gain-of-function mutations, but also sporadic diseases where the disease pathways are understood. For example, if the amyloid hypothesis for Alzheimer disease is correct (Hardy and Selkoe, 2002), RNAi can be used to downregulate BACE and/or other proteins that are involved in the production of Aβ, a substrate for β amyloid that is postulated to cause neuronal degeneration.
Cattaneo E, Rigamonti D, Goffredo D, Zuccato C, Squitieri F, Sipione S. Loss of normal huntingtin function: new developments in Huntington's disease research. Trends Neurosci. 2001 Mar;24(3):182-8. PubMed.
Ding H, Schwarz DS, Keene A, Affar el, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z. Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell. 2003 Aug;2(4):209-17. PubMed.
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002 Jul 19;297(5580):353-6. PubMed.
Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5820-5. PubMed.
Kimmelman J. Recent developments in gene transfer: risk and ethics. BMJ. 2005 Jan 8;330(7482):79-82. PubMed.
Miller VM, Xia H, Marrs GL, Gouvion CM, Lee G, Davidson BL, Paulson HL. Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7195-200. PubMed.
Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DC, Wong LF, Bilsland LG, Greensmith L, Kingsman SM, Mitrophanous KA, Mazarakis ND, Azzouz M. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat Med. 2005 Apr;11(4):429-33. PubMed.
Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med. 2005 Apr;11(4):423-8. PubMed.
Shi Y. Mammalian RNAi for the masses. Trends Genet. 2003 Jan;19(1):9-12. PubMed.
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 2004 Nov 11;432(7014):173-8. PubMed.
Thakker DR, Natt F, Hüsken D, Maier R, Müller M, van der Putten H, Hoyer D, Cryan JF. Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17270-5. PubMed.
Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev. 2005 Mar 1;19(5):517-29. PubMed.
Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med. 2004 Aug;10(8):816-20. PubMed.
Xia XG, Zhou H, Zhou S, Yu Y, Wu R, Xu Z. An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase. J Neurochem. 2005 Jan;92(2):362-7. PubMed.View all comments by Zuoshang Xu


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Blush Pink Denver Pillow Cover
Reed Feather Straw pillow covers are handcrafted in the United States. Each throw pillow cover is made with 100% upholstery weight cotton fabric that feature unique and colorful designs. Transform your home with decorative pillows from Reed Feather Straw.
- Process Time: 10 - 15 business days (Monday - Friday, excluding holidays).
- Material: Made with 100% light weight upholstery fabric.
- Cover Closure: Envelope.
- Fabric Design: Is continuous on both front and back.
- Care: Machine wash cold with gentle detergent (Woolite).
- Additional Note: Pillow insert sold separately.