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A Phase 3 Study to Evaluate Marqibo® in the Treatment of Subjects ≥ 60 Years Old With Newly Diagnosed ALL
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01439347
Recruitment Status : Terminated (Sponsor decision)
First Posted : September 23, 2011
Last Update Posted : July 22, 2016
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Acute Lymphoblastic Leukemia (ALL)
|Drug: Vincristine Sulfate Liposomes Injection (VSLI) Drug: Vincristine Sulfate Injection (VSI)
|Phase 3
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|26 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase 3 Study of Study to Evaluate Marqibo® in the Combination Chemotherapy in the Treatment of Subjects >or=60 Years Old With Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
|Study Start Date :
|March 2012
|Actual Primary Completion Date :
|November 2015
|Actual Study Completion Date :
|November 2015
Active Comparator: Vincristine Sulfate Injection (VSI)
This is a phase 3, international, multicenter, open-label randomized, controlled trial with 2 treatment arms that vary only in the administration of standard VSI vs. Marqibo. Eligible subjects will be randomized to combination chemotherapy containing either VSI or Marqibo
Drug: Vincristine Sulfate Injection (VSI)
1.4 mg/m2 with a 2 mg dose cap as an intravenous (IV) infusion over 10 minutes
Other Name: Vincristine
Experimental: Marqibo
administration of standard VSI vs. Marqibo
Drug: Vincristine Sulfate Liposomes Injection (VSLI)
2.25 mg/m2 (without any dose cap) as an IV infusion over 60 minutes
Other Name: Marqibo
- Primary Efficacy Criterion [ Time Frame: 24 months of Sequential Induction ]Overall Survival will be measured for all subjects from the date of randomization until death from any cause.
- Secondary Efficacy Criteria [ Time Frame: Complete Remission ]Complete remission )CR+CRi; best response during study Duration of Response (CR+CRi) Event Free Survival(EFS)will be measured from the date of randomization until the date of the earliest of the following events: Death from any cause, relapse from CR/CRi, Bone marrow and or blood examination documentation failure to achieve CR/CRi following the last course of radiation therapy
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|60 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Have provided written, signed, and dated informed consent to participate in the study, in accordance with the ICH GCP Guideline E6 and all applicable local regulations.Are age >or=60 years (at the time of providing informed consent).
Have newly diagnosed, histologically proven, untreated Philadelphia chromosome-negative (Ph-) ALL, with >or= 5% bone marrow blasts.
Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. Have a life expectancy >or= 3 months.
Have renal and liver function as defined below within 14 days, inclusive, prior to study enrollment, unless the abnormality is considered attributable to leukemia:
Total bilirubin ≤ 2.0 x the upper limit of normal (ULN), unless the subject has a known diagnosis of Gilbert's disease Aspartate transaminase (AST, SGOT) or alanine transaminase (ALT, SGPT) ≤ 3 x ULN Serum creatinine ≤ 1.5 x ULN. Not have had major surgery within 4 weeks before the planned start of treatment.
If female, are post-menopausal, surgically sterilized, or willing to use acceptable methods of birth control (eg, hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) from the screening visit through 30 days after the last dose of any protocol defined chemotherapeutic agents.
If male and sexually active with a partner of child-bearing potential, agree to use an acceptable barrier method for contraception from the screening visit through 30 days after the last dose of any protocol defined chemotherapeutic agents.
Have the ability and willingness to fully comply with study procedures and restrictions.
Exclusion Criteria:
Has had prior systemic chemotherapy (for ALL or other malignancy). Has had prior vincristine for any reason. Is planning to undergo stem cell transplantation (SCT) as any part of first-line therapy for ALL.
Has Burkitt's lymphoma/leukemia. Has Philadelphia chromosome-positive (Ph+) ALL and/or BCR/ABL rearrangements documented by fluorescent in-situ hybridization (FISH), cytogenetics, or polymerase chain reaction (PCR).
Has active central nervous system (CNS) disease. Has ongoing neuropathy of any etiology > Grade 1. Has a history of persistent active neurologic disorders including demyelinating form of Charcot-Marie-Tooth syndrome, acquired demyelinating disorders, and other demyelinating conditions.
Prior hydroxyurea (Hydrea®) for the management of any condition other than leukocytosis or prior hydroxyurea of >7 days duration for the management of leukocytosis (hydroxyurea for the management of leukocytosis must be planned to be tapered off before or on Day 5 of Induction).
Has received prior steroids within 7 days before beginning protocol-specified Induction therapy for reasons other than leukocytosis (steroids for the management of leukocytosis are allowed but must be planned to be tapered off before or on Day 5 of Induction).
Has an active serious infection not controlled by oral or IV antibiotics or antifungals.
Has received any investigational therapy within 28 days before beginning any protocol-defined chemotherapeutic treatment.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01439347
|United States, California
|UC San Diego Moores Cancer Center
|La Jolla, California, United States, 92093
|Los Angeles, California, United States, 90095
|United States, Georgia
|Emory University, Winship Cancer Institute
|Atlanta, Georgia, United States, 30322
|United States, Illinois
|Northwestern University Fienberg School of Medicine
|Chicago, Illinois, United States, 60611
|University of Chicago
|Chicago, Illinois, United States, 60637
|United States, Michigan
|Karmanos Cancer Institute
|Detroit, Michigan, United States, 48201
|United States, Missouri
|Washington University School of Medicine
|St. Louis, Missouri, United States, 63110-1093
|United States, Nebraska
|Nebraska Medical Center
|Omaha, Nebraska, United States, 68198-7680
|United States, New Jersey
|Hackensack University Medical Center
|Hackensack, New Jersey, United States, 07601
|United States, New York
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|New York, New York, United States, 10021
|United States, North Carolina
|Duke University Medical Center
|Durham, North Carolina, United States, 27710
|United States, Ohio
|Cleveland Clinic
|Cleveland, Ohio, United States, 44195
|United States, Texas
|The University of Texas, M.D. Anderson Cancer Center
|Houston, Texas, Texas, United States, 77030-4009
|United States, Washington
|Seattle Cancer Care Alliance
|Seattle, Washington, United States, 98109
|Principal Investigator:
|Susan M O'Brien, MD
|MD Anderson
|Responsible Party:
|Spectrum Pharmaceuticals, Inc
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 23, 2011 Key Record Dates
|Last Update Posted:
|July 22, 2016
|Last Verified:
|July 2016
acute lymphoblastic leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action


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This article is not part of the Holby universe.
This article covers a subject that is part of the real world, and thus should not be taken as a part of the Holby universe.
"No Place Like Home" is the 241st episode of Casualty and the 15th episode of the 13th series.
Community content is available under CC-BY-SA unless otherwise noted.


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Interlinear Bible
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Matthew Henry Concise Commentaryon the Whole Bible
Chapter 8
Christ, as Wisdom, calls to the sons of men. (1-11) The nature
and riches of Wisdom. (12-21) Christ one with the Father, in the
creation of the world, and rejoicing in his work for the
salvation of man. (22-31) Exhortations to hear Christ's word.
Verses 1-11
The will of God is made known by the works of creation,
and by the consciences of men, but more clearly by Moses and the
prophets. The chief difficulty is to get men to attend to
instruction. Yet attention to the words of Christ, will guide
the most ignorant into saving knowledge of the truth. Where
there is an understanding heart, and willingness to receive the
truth in love, wisdom is valued above silver and gold.
Verses 12-21
Wisdom, here is Christ, in whom are all the treasures of
wisdom and knowledge; it is Christ in the word, and Christ in
the heart; not only Christ revealed to us, but Christ revealed
in us. All prudence and skill are from the Lord. Through the
redemption of Christ's precious blood, the riches of his grace
abound in all wisdom and prudence. Man found out many inventions
for ruin; God found one for our recovery. He hates pride and
arrogance, evil ways and froward conversation; these render men
unwilling to hear his humbling, awakening, holy instructions.
True religion gives men the best counsel in all difficult cases,
and helps to make their way plain. His wisdom makes all truly
happy who receive it in the love of Christ Jesus. Seek him
early, seek him earnestly, seek him before any thing else.
Christ never said, Seek in vain. Those who love Christ, are such
as have seen his loveliness, and have had his love shed abroad
in their hearts; therefore they are happy. They shall be happy
in this world, or in that which is beyond compare better. Wealth
gotten by vanity will soon be diminished, but that which is well
got, will wear well; and that which is well spent upon works of
piety and charity, will be lasting. If they have not riches and
honour in this world, they shall have that which is infinitely
better. They shall be happy in the grace of God. Christ, by his
Spirit, guides believers into all truth, and so leads them in
the way of righteousness; and they walk after the Spirit. Also,
they shall be happy in the glory of God hereafter. In Wisdom's
promises, believers have goods laid up, not for days and years,
but for eternity; her fruit therefore is better than gold.
Verses 22-31
The Son of God declares himself to have been engaged in
the creation of the world. How able, how fit is the Son of God
to be the Saviour of the world, who was the Creator of it! The
Son of God was ordained, before the world, to that great work.
Does he delight in saving wretched sinners, and shall not we
delight in his salvation?
Verses 32-36
Surely we should hearken to Christ's voice with the
readiness of children. Let us all be wise, and not refuse such
mercy. Blessed are those who hear the Saviour's voice, and wait
on him with daily reading, meditation, and prayer. The children
of the world find time for vain amusements, without neglecting
what they deem the one thing needful. Does it not show contempt
of Wisdom's instructions, when people professing godliness, seek
excuses for neglecting the means of grace? Christ is Wisdom, and
he is Life to all believers; nor can we obtain God's favour,
unless we find Christ, and are found in him. Those who offend
Christ deceive themselves; sin is a wrong to the soul. Sinners
die because they will die, which justifies God when he judges.
Bibliography Information
Henry, Matthew. "Concise Commentary on Proverbs 8". "Matthew Henry Concise Commentaryon the Whole Bible". <http://classic.studylight.org/com/mhc-con/view.cgi?book=pr&chapter=008>.
Dead links, typos, or HTML errors should be sent firstname.lastname@example.com about making this resource more useful should be sent email@example.com
Copyright © 2001-2020, StudyLight.org


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Friends, coworkers, strangers to help Aimee Copeland | News
AUGUSTA, Ga. -- Doctors have told Aimee Copeland's family she is in for a roller coaster of good and bad days over the next few weeks.
Her father tells us she is talking, laughing, and smiling with her family in the hospital intensive care unit.
It's been more than two weeks since the West Georgia University grad student cut her leg in a zipline accident and contracted a flesh-eating bacteria.
RELATED | Aimee's fight for life
The Carrollton community has rallied around her.
They've planned a fundraiser at her workplace, Sunnyside Cafe, on Rome Street. The event starts at 7 p.m. Friday. There will be music and raffles.
RELATED | How to help Aimee
Money raised will go directly to Aimee to help her through her recovery. Her best friend told us they don't want Aimee to worry about money, and how she'll support herself.


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Barnett under fire for abuse comment
West Australian Premier Colin Barnett has been called on to apologise to victims of child abuse after claiming the royal commission into child sex abuse could destroy institutions around the country.
Prime Minister Julia Gillard last week announced a far-reaching national inquiry would be held into abuse and allegations of abuse across many years and institutions.
On ABC radio on Monday, Mr Barnett said he held grave concerns about the legacy the massive inquiry may leave on the organisations investigated and the victims involved.
But the state opposition said the premier's reservations made light of the abuse suffered by many people over many years.
"The suggestion that we should avoid exposing individuals or institutions that have been involved in the sexual abuse of children because it may tarnish their reputation shows an appalling lack of sensitivity," opposition child protection spokeswoman Sue Ellery said.
"Most Western Australians would be appalled that the premier appears more concerned about protecting the perpetrators than providing a platform to investigate abuse claims."
Mr Barnett urged the government to "think very carefully" about the terms of reference and breadth of the inquiry, which he hoped would achieve positive outcomes.
"But I also fear for the negativity that could come out of it," he said.
"I think you will see many people's lives destroyed. I think you will see many of Australia's institutions - which may have been at fault - also destroyed, and great divisions in the community."
WA held its own inquiry into child sex abuse this year, focused on events in the 1970s and 1980s at the St Andrews Hostel in Katanning, run by notorious pedophile brothers Dennis and Neil McKenna.
The inquiry was later expanded to St Christopher's hostel in Northam, Hardie House in South Hedland and St Michael's House in Merredin.
Mr Barnett also said on Monday he was unsure about the prudence of including historical cases in the national inquiry and what effect it might have on the victims.
"This could be very divisive, and people dealing with issues that may have happened 20, 30, 40, 50 years ago... replayed that time later. I don't know exactly where that will lead us," Mr Barnett said.
"I would urge ... a restriction on the time of this commission."
But Ms Ellery said the royal commission would be an important part of the healing process.
"Investigations must be handled sensitively, but for too long the issue of child abuse by people in positions of authority has been placed in the 'too hard' basket or surrounded by secrecy," Ms Ellery said.
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The week might end, but new apps do not. And we've got all kinds of greatness coming at you this week—a shopping app, a TV guide, and more.
Basher's Presidents: If all the U.S. presidents of history got into a massive knife fight, who would be the last left standing? That's a very good question—one you can answer by downloading this adorably illustrated presidential history app that gives you a combination of essentially facts and fun but educational games. $1.99
Net-A-Porter: Oh those Lanvin sneakers look good. And if you can't wait to snag a pair for yourself, now you can buy your designer duds anywhere, anytime from your iPad from online retailer Net-A-Porter's new iPad app. You can buy shoes, clothes, accessories, and all the haute couture your closet can handle, just in time for fall.
NextGuide: The guide on your television is a piece of crap. You have to scroll through titles of shows and nothing sticks out. NextGuide is trying to reinvent that by linking up with your cable account and offering up a few of your favorite shows, actors, and interests, all arranged in a grid. Unfortunately, just Hulu and DirecTV are supported. Free


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Few people know that when Giovanni da Verrazano sailed into New York Harbor in 1524 he first landed on Staten Island. Though the Island was possibly the first place that European explorers arrived on land, Staten Island often seems last when it comes to implementing public policies that improve the quality of city living. Staten Island has all the problems facing the rest of the city--unplanned and uncoordinated growth, traffic congestion, and disappearing open and public space.
But nestled in this borough bounded by bays and kills are a few model solutions as well. The Staten Island Bluebelt, for instance, uses wetlands to capture stormwater runoff and, with nature's help, treats this tainted water for half the cost of the mechanical treatment that is necessary in more densely paved parts of the city. The Island has the only ferry in New York City that truly functions as public transportation: it runs 24 hours a day and is free (yes, FREE) to all riders. Just north of Fresh Kills landfill sits a paper re-manufacturing plant that takes a portion of the city's solid waste stream and uses these scraps to produce marketable goods, in large quantities. Looking ahead, the island is poised to become a choice borough if it can capitalize on its most famous assets, particularly its geographic proximity to (gasp!) New Jersey.
The island nature creates an insular feeling among residents and visitors alike. When viewed with Brooklyn, Queens and Manhattan, it seems to many people that only Staten is an island, when in fact four of the five boroughs really rest on islands as well. This psychological sense of non-belonging last culminated in a referendum question in 1993 in which islanders voted to form their own city, though the State Legislature never approved the secession. Three years later Fresh Kills landfill closed.
For a half century Fresh Kills landfill was both the largest physical landmark as well as psychological burden which islanders carried with them wherever they went. The closure of the landfill, while a mental boon for islanders and a boost to property owners, has not yet brought about a sustainable or even sane solid waste management policy for the city. But we are getting closer. Recently, officials from VISY paper organized a tour for borough leadership of a solid waste handling and sorting facility in Germany that is as close to the state of the art as anything in existence in the U.S. While garbage is not pretty business, the reality is that it is New York City's largest export as well as an expense item that accounts for nearly three percent of the city's annual budget. It is a problem we will have to solve to survive as a city.
In many ways the landfill's swing from open to closed is characteristic of the highly politicized nature of land use decision-making that afflicts US cities with the urban planning equivalent of bipolar disorder: now it is wide open, now it is sealed shut. Rarely is there any in-between. But fortunately for New York there is Staten Island.
The latest instance of this bi-polar disorder was diagnosed this past July, when Mayor Michael Bloomberg announced the creation of a task force to examine "growth management" on the island. Often derisively referred to as an overdevelopment task force, this entire effort, and the land use debate on the island, should instead be framed as an under-transit task force. It is a well-known fact that islanders feel alienated from much of the rest of the city. While they have only two linkages (a bridge to Brooklyn and a ferry to Manhattan) they have three connections to New Jersey in the form of the Outerbridge, the Goethals, and the Bayonne Bridges.
But as the population of the island has doubled since the time the Verrazano Bridge opened in 1964, the island has not added any new physical connections to surrounding boroughs or cities. Sure new funds are being tapped for additional express buses to Manhattan, but what the island needs desperately are new transit options that reduce pressures on the bridge and ferry crossing already jammed to capacity. For instance, the congestion on the Staten Island Expressway will not be solved with widened on-and off ramps here and there, but if there were other options such as passenger ferries or even truck ferries between New Jersey and Brooklyn the commuters and goods would actually have an option of how to travel.
A borough of nearly half a million people needs better transit not just between boroughs but within Staten Island itself. With rail lines along the west and north shores of the island now sitting idle for decades, how long can it be before policymakers realize that the solution to the island's development pressures woes are the mostly intact rail rights-of-way that are staring them in the face?
Perhaps the most visionary thinking for Staten Island has originated outside the state. Just a couple of years ago the executive director of New Jersey Transit suggested that the new Hudson Bergen Light Rail that now ends just across the Bayonne Bridge might someday pass over the Bayonne Bridge and all the way down to Tottenville at the southern tip of Staten Island. Such imaginative and apolitical thinking is what this congested island will need to prosper in the future. Beholden to a city and state so fixated on Lower Manhattan, perhaps Staten Islanders would be better off taking their case to Trenton.
Carter Craft, an urban planner, is program director of the Metropolitan Waterfront Alliance.


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"Vote And Don't Forget" | Online Resources To Keep Your Elected Officials Accountable
It is election time again and everyone is telling us it is very important that you vote in this election and make your voice heard. So your voice should be only heard on one day every 2 and 4 years? That doesn't seem right, does it? Voting is only one part of your civic duty and responsibilities.
We as citizens need to be more involved in the process than just on election day. How many of us contact our elected official during their term? How many of us see what bills are up for a vote? How many of you know how your elected official voted on a particular bill? We as a country seem to ignore what our politicians are really doing until the next election. It is sort of like a parent not checking on their young kids while they are left at home by themselves and then coming home and finding your home burned down to the ground. The law calls this child neglect. In case of our elections, it should be called "Voter Neglect." Most employers hold periodic reviews of their employees. We as citizens need to do the same for our elected officials. We are their bosses and it is not the other way around. If more of us did this, the lobbyists and self-interest groups would not have as much influence as they do now. So I ask you on November 2nd to "Vote and Don't Forget."
One might say, that is great, but I do not know how to contact my elected official or even find what bills are up for a vote. I have put together several online resources that makes it easy to contact and track your elected official during their term.
The first online resource is called Open Congress and it's purpose is to make Congress more transparent and to encourage civic engagement. Open Congress is a free, open-source, non-profit and non-partisan web resource where anyone can track elected officials, bills, issues, and even track money contributed to campaigns and elected officials. The site tracks bill in both the house and senate and how each elected official voted. You can set up an account an track or follow the bills or issues that concern you and get updates. You can even vote on the bills yourself, give personal approval ratings to Members of Congress and even write your elected official directly. The site even allows you to track the top bills that are supported by Wisconsin users of the site. There are actually close to 2,500 Wisconsin users of Open Congress.
The site even has resources, tools, and widgets that you can place on your site or even share with your Facebook friends. Here are some of the tools that you can use to educate yourself and others:
– Head to Head Vote Comparison – Compare voting records between two elected officials
– OpenCongress Facebook Application – This allows you put bills and issues that interest you on your Facebook profile
– Health Care Reform Widget – Track and display the status of major health care reform bills in congress on your site or blog.
– Bill Status Widget – Tracks the status of any bill in Congress
You should definitely take a look at this site before and after the election.
Congress.org is the next online resource to help you get informed and educated about what is going on with Congress. It is similar to Open Congress except that is focuses on making it easy to write your elected official. Over 8 millions letters have been sent to congress via Congress.org. Once you sign up for an account, the site creates a user profile where you can send letters to your officials, track your local elected official votes in Congress, get email updates on the issues that concern you and more. You can even write a "Soapbox Alert", which is a public message that other site users can read and use in their own letters to Congress. In addition to all these great tools, Congress.org writes some great articles on the political process.
Votesmart.org is a site that is described as "The Voter's Self-Defense System." You should definitely use this site before you go to the polls on November 2nd. The site has information on biographical information about candidates and elected officials, their voting records, issue positions, public statements and even campaign finances. They even have resources for candidates, journalists and teachers. They even have information about bills in each of the states including Wisconsin.
Votesmart.org created an amazing visual tool to help be a better educated voter called VoteEasy. You pick the issues that concern you and see where the candidates stand on them.
A really interesting tool is called the Political Influence Tracker, which was created by a partnership between Wired Magazine and Maplight Foundation. The tool tracks all the contributions a candidate receives and where those contributions originate from. You can embed the information on your own website or blog. Below is an example of two Wisconsin elected officials and the money they get for campaigns.
The final resource is homegrown and is called WisconsinVote.org. The site is a service of Wisconsin Public Radio and Wisconsin Public Television. The site is a dedicated resource for Wisconsin voters.. The site has profiles of all the candidates in Wisconsin running for political office.
I hope these various resources helps you be a better informed voter and I also hope you use these tools to keep your elected officials accountable. Remember "Vote, And Don't Forget!"


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PROVIDENCE, R.I. (AP) — A new criminal defense lawyer for the widow of Boston Marathon bombing suspect Tamerlan Tsarnaev says his client will continue to cooperate with investigators but says he plans to keep quiet about the details of her case publicly because that could hurt the investigation.
New York lawyer Joshua Dratel, who has represented several terrorism suspects, joined Katherine Russell's legal team last week. He joins two Rhode Island-based lawyers who typically focus on civil cases.
Russell hasn't been charged with any wrongdoing, but she is under intense scrutiny by the FBI as it investigates the deadly April 15 bombing, which killed three people and injured more than 260. Authorities say the attack was carried out by her husband and his brother, Dzhokhar Tsarnaev.
Dratel told The Associated Press on Tuesday that he joined Russell's legal team because Russell needed someone who could navigate the criminal justice system and to protect her interests.He said she had spoken with investigators and planned to keep cooperating.
"I don't see that changing in the foreseeable future," he said. "There's no inconsistency between that and her interests at this point."
Dzhokhar Tsarnaev, 19, is in a prison hospital facing charges that could bring the death penalty. Tamerlan Tsarnaev, 26, died April 19 after a shootout with police.
Russell, 24, had been living in Cambridge, Mass., with her husband and 2-year-old daughter, but has been staying with her parents in North Kingstown, R.I., since the day her husband was killed. She has reverted to using her maiden name, switching from her married name of Tsarnaeva.
Among the questions about Russell is what she knew or saw in the weeks leading up to the bombing, and in the days after it. Two U.S. officials, speaking on condition of anonymity, have told the AP that Dzhokhar told investigators the bombs were assembled in the small apartment Russell shared with her husband. One of her Rhode Island lawyers has previously said she was working long hours and was frequently away from the apartment.
Dratel would not discuss details of Russell's life or relationship with her husband, and would not be specific when asked about her contact with federal investigators, such as when she had spoken with them. He said in his experience, investigators do not want people speaking to the media and publicizing what they are focusing on.
"It would be counterproductive for the investigation and for Katherine's interests for us to be more forthcoming at this time with any of the details," he said. "We wouldn't want to impair the investigation in any way."
The sole focus of Russell and her legal team, he said, was on the investigation.
"It's a fluid situation," Dratel said. "We're not at the end of it."
Lawyer: Tsarnaev's widow to cooperate
PROVIDENCE, R.I. (AP) — A new criminal defense lawyer for the widow of Boston Marathon bombing suspect Tamerlan Tsarnaev says his client will continue to cooperate with investigators but says he plans to keep quiet about the details of her case publicly because that could hurt the investigation.


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Far too many speaker docks for Apple products are boring black boxes. These hand-built aluminum docks shaped like the exhaust pipes from hot rods are some of the most creative we've seen in awhile.
Designed in Italy, iXoost docks come in three models: eight cylinders, 10 cylinders, and 12 cylinders. The eight- and 10-cylinder models both have two 28mm tweeters, two 25mm mid-ranges, a 100mm sub, and a 200mm sub—the latter model is larger in size. The 12-cylinder model adds a third tweeter, midrange, and 100mm sub.
But what really sets these hot rods apart is their gorgeous design that's available in a variety of anodized finishes and leather trims. The price of these things is still unknown, but considering that each piece is a custom build—they're modeled on hot rods after all—we expect that price varies by how badass you want your dock to be. [iXoost via Cult of Mac]


text:
This site is the archived OWASP Foundation Wiki and is no longer accepting Account Requests.
To view the new OWASP Foundation website, please visit https://owasp.org
WebAppSec.php: Developing Secure Web Applications
AppSec USA 2011 - Course Sold out
AppSec DC 2010 - see below
Registration | Hotel | Walter E. Washington Convention Center
Course Length: 1 Day
Web applications are the new frontier of wide‐spread security breaches. This tutorial will guide through development practices to ensure the security and integrity of web applications, in turn protecting user data and the infrastructure the application runs on. Several attack types and risks will be reviewed (including OWASP's Top 10), along with how the proper development practices can mitigate their damage. Although examples covered are PHP‐based, much of the content is also applicable to other languages.
This will be an updated, encore presentation of last year's well received course. Following are quotes from prior WebAppSec.php attendees:
- "Presented in a very structured format. Instructor knew his stuff. Good presentations."
- "Very knowledgeable! Covered a lot of topics in a limited amount of time"
- "The presenter was excellent. He didn't present an overload of information. The day went very quickly and I am leaving with a lot of valuable information"
- "The slides were excellent - full of good code examples and explanations"
- "Material that was presented was presented and covered well. Instructor is very knowledgeable"
- "Handouts & presentation well organized & coordinated"
All course registrants will receive printed materials and a certificate of completion which may be used for documenting CPE credits.
Student Requirements
Skill: Any - some knowledge of web development will be helpful
Attendees will gain the knowledge required to develop secure web applications, along with an understanding of various attack types against web apps and how they are mitigated by the proper coding techniques. The main learning objectives are:
- Developing the skills for securely coding web applications
- Reviewing existing web vulnerabilities and their impact
- Understanding how the proper development techniques mitigates known and some unknown web vulnerabilities
Instructor: Robert Zakon Robert Zakon is a technology consultant and developer who has been programming web applications since the Web's infancy. In addition to developing web applications for web sites receiving millions of daily hits, he works with organizations in an interim CTO capacity, and advises corporations, non‐profits and government agencies on technology, information, and security architecture and infrastructure. Robert is a former Principal Engineer with MITRE's Information Security Center, CTO of an Internet consumer portal and application service provider, and Director of a university research lab. He is a Senior Member of the IEEE, and holds BS & MS degrees from Case Western Reserve University in Computer Engineering & Science with concentrations in Philosophy & Psychology. His interests are diverse and can be explored at www.Zakon.org where his vitae is available.


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** 1/6/13 Top 3 Winner at Whoopsidaisy! **
** 12/31/12 Top 3 Winner at Tammy's Scrappin Corner! **
** 12/31/12 Top 3 Winner at Tammy's Scrappin Corner! **
The last few days have been a whirlwind! Hope you all had a wonderful Christmas! Santa brought me a new laptop as my last one was four years old and the screen was periodically going black on me while working. The old one had Vista and this new one has Windows 7. Of course, the way my luck goes, the version of PhotoShop I've been using on the old laptop won't work on this new one so I had to find a quick fix to get this card posted. I've done quite a bit of internet research over the last 24 hours and have found free (yes, free!) photo editing software called Gimp which works like a charm! I'm so stoked! I've discovered that my Microsoft Office 2007 won't work on this new laptop either (sigh) so the bucks I'll save by not having to purchase a new version of PhotoShop will more than pay for Microsoft Office 2010 that I need!
Just thought I'd share my good fortune, so now on with this post... The theme for this week's Dutch Dare Card Challenge #197 is "Celebration" and the challenge is sponsored by Crafty Sentiments Designs! Come play with us! I made a shabby chic new baby girl card and chose the adorable "Toby with Present" digi to play with. I paper pieced the image and layered it upon a few more layers. I got to use some papers from a very cool new 6x6 paper pack that I've not yet had an opportunity to use, which is always fun! Had a great time making this card and I'm really pleased with the way it turned out!
I'd like to enter this sweet card into the following challenges:
- Tammy's Scrappin Corner Challenge #42 - Come Play Bingo With Us (Flowers/Pearls/Pattern DP)
- Sweet Stampin - Seeing Double (two groups of three flowers)
- Tuesday Alchemy Challenge #46 - Anything Goes
- Challenges 4 Everybody Challenge #10 - Anything Goes
- Fab 'n' Funky Challenge #152 - Add Ribbon and/or Lace
- Paper Crafting Journey - Anything Goes Challenge
- Aud Sentiments - Use Any Sentiment!
- Whoopsidaisy Challenge - Celebrate
- Gina K Designs Pure Luxury ivory cardstock; Pretty In Pink 6x6 Glitz paper pack; Paper and More ivory canvas and chocolate cardstock; kraft cardstock from stash
- Crafty Sentiments "Toby with Present" digital image
- Ranger Victorian Velvet distress marker; Sakura Stardust pen; R20 Copic marker
- Ranger Antique Linen distress ink
- Spellbinders Classic Circles and Lacey Circles dies
- Cheery Lynn Italian Flourish die
- Lily of the Valley Circular Sentiment stamp
- Memento Rich Cocoa ink
- Wild Orchid Crafts ivory crochet lace
- Pink paper flowers from stash; pink flat-back pearls


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Home → All Products → n.y
All Products - Items tagged as "N.y"
Assortment of Cool Belt Buckles styles for men, women, boys and girls. Also fashion clothing accessories such as winter Toques, Hats, Ball Caps, Jewellery, Canadian and American Souvenirs!
Ideal gifts - Unisex fashion clothing accessories gifts for any age or gender!
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belt buckles for tattoo artist belt buckles for women belt buckles unisex Belts belts and buckles belts buckles belts with buckles Beseball big big apple big fat bastard big game big game hunting Bike Biker biker's Bikers Bikes Billars Bird Birds Bitch black belt bling Blue Body Bolt bomber hat Boobs Boot Boots booze Bottle bottle opener Bottles boucle boucle de ceinture boucle de ceinture pour charpentier boucle pour ceinture boucles de ceinture boucles et ceintures boucles pour ceintures Bow bow & arrow bow and arrow bow tie bow ties Bowling bowling buckle Bows bows & arrows bows and arrows Boys brasil brasil flag brasilian brass brazil brazil flag brazilian bridge British Columbia Brown Buckle buckle with belt Buckles buckles and belts buckles belts buckles for belts buckles for boys buckles for girls buckles for men buckles unisex bucklesbuckle bucle Bug bugs bulgaria bulgarian bull bull horns bull rider bull riders bulldog bulldogs Bulls Bullshit bus driver bus drivers buses 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country music buckle couvreur Cow Cowboy cowboy boot cowboy buckles cowboys Cowgirl Cowgirls cowsteer cowsteers craps Crest crime family cross cross belt buckle cross bones cross buckle crossbone crossbones crossbones belt buckle crossbones buckle Crosses crown crown buckle Crowns cuba cuba flag Dagger Danger DART BOARD DARTS decorative Deer dice dices DINNER BELL Disco dog Dogs Dollar dollar sign door knocker Dragon Drapeaux dream catcher dream catcher cap dream catcher caps drink drinks driver drivers duck duck key rack ducks e.v Eagle eagle belt buckle eagle buckle eagle eagles eagles easy rider Eight Electrician Electricity elk end of the world ENGLAND england's English estonia estonia flag estonian euro buckle euro sign european buckle excavator extra large F Face Faces facial FALLS farm fashion belt fashion belt buckles fashion for women fashion jewelry Fat faux fur winter hat Fd Feather Feathers fire dept fire truck fire truck buckles Firearm Firefighter Fireman fireman's 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grey wolf GRIM REAPER Grizzlies group Groups guevarra Guitar guitar belt buckle guitar buckle guitar player Guitars Gun gun belt buckle gun buckle gun buckles guns H hair cut Haiti Handgun Hat hats HAWAII hawaii belt buckle hawaii buckles Hawaii Souvenir heart belt buckle Hearts Hero Hippie hippie van Hippy HOLLAND Homy horns horoscope horoscope buckle Horoscopes Horse horse belt buckle horse belt buckles horse buckle horse buckles horses horses belt buckles house house pets howling wolf Humor humor buckles hungary hungary flag hungary flag buckle Hunter hunter belt buckle hunter's hunters hunters cap hunters hat Hunting hunting baseball cap i fear no beer ice fishing ice fishing buckle india Indian Indians Initial initial letter Initials Insect Instrument Instruments international flags Ireland irish irish belt buckle irish flag buckle Islam israel israel flag Italian italy J j'aime jamaica jamaica flag jamaica flag belt buckle jamaica flag buckle JAPAN je me souviens jerk jerk belt buckle jerk buckle jewelry Joke Jokes Kandahar Key key chain key rack kid kids king king of the road kings knot L labrador labrador belt buckle labrador buckle Ladybug large las vegas las vegas buckle last frontier leather belt leather belts Letter letter initial letter opener Letters lifeguard light light switch light switch cover lily fower line dance lion lion belt buckle lion buckle lion head buckle Lis live to ride Lock long hair longhorn longhorn belt buckle longhorn buckle longhorns loud pipes save lives loud pipes save lives buckle love cooking Lowrider lucky lucky shamrock M machinist machinist buckle macon Mafia mall cop Map maple leaf Marijuana martial arts MASK MASK BELT BUCKLE MASK BUCKLE masks masquerade MASQUERADE MASK Maya Mayan calendar calendar MECANICIEN mecanique mecanique boucle de ceinture mechanic buckles mechanic tools men's buckles mens belt buckles metal metal bell metal coasters Mexican mexican flag mexico mexico flag Military monaco monarch butterfly Money money talks money talks belt buckle monkey Monogram Monograms Montreal montreal buckle moose moose belt buckle moose buckle Motor Motorcycle motorcycle belt buckle Motorcycles mud flap girl mud flap girls Mug Music music buckle music buckles Musician my other ride buckle n.y Name Names National national flag Native Natives navy netherlands netherlands flag new orleans new york New York City new york twin towers NIAGARA NIAGARA FALLS night owl night owls no more bullshit Nort North north american Northern Nude Ny ny belt buckles for men women occupation occupation belt buckle octopus octopus belt buckle octopus buckle off road old old flag old hippie old Montréal Opener Openers operators oriental Oval owl owl belt buckle owl belt buckles owl buckle owl buckles owls painter paramedical paramedical buckle peace & love peace and love peace belt buckles peace buckles peace love PEINTRE peru peru flag pet Pets pick up lines pick up linespick up Piercing Pink Pins Pirate pirates Plated Player Players poison poker poker hand Pom pom pom pompier pompom hat Pool Portugal portugal flag portugal souvenir portuguese portuguese flag pot pot leaf pot marijuana Prey prey birds profession professions puerto rican puerto rico puerto rico flag Q Quebec quebec belt buckle quebec buckle Quebec Flag quebecois Queen Quinas radio radios ranch Red red cherries red cherries buckles red maple leaf retro retro disco Rhinestone rhinestone belt buckle rhinestone belt buckles rhinestone buckle rhinestone buckles rhinestone star Rhinestones ride to live Rider Riders Rifle Rings road warrior Rock Rodeo rodeo buckles Rodeos Roman roman fountain roof worker roofer rottweiler rottweiler buckle route route 66 royals russia S Saints Saumon school school bus school bus driver schools scorpio Scorpion scorpion belt buckle scorpion buckles Scotland sex pistols sex pistols belt buckle sex pistols buckle Sexy shamrock shoehorn Shoes shop sign Signs Silver silver plated sitting bull skeleton skeletons Ski ski hat Skull skull belt buckle skull buckles skull head skullgun skulls Smile Smoke smoking pot snake Snakes snap on belt snap on belts snapon Snooker snowflakes soccer soccer ball buckle soccer mom Soldiers soudeur Sound south america south american SOUVENIR souvenir ashtray souvenir bell Souvenirs spain spain sweatband Spanish spinner spinners Sport Sports sports buckle stadium Star star belt buckle star buckle Stars State statue of liberty Steers Stone Stones strawberry Style Sun sunshine sunshine buckle sweatband Swords Symbols table Tag Tags Tanks Tapes tattoo artists tattoo saying yeah it hurts belt buckle Tattooing Team Tennis Texas texas longhorn texas longhorns theater these colors do not run Tie tiger Toad tools Toques TOTEM POLE Trade Trades trencher Truck truck's mud flap girls trucker trucker buckle trucker's truckers trucks Tuques twin towers two head eagle belt buckle uk union jack unique belt buckles unique buckles unisex belt unisex watch united kingdom united kingdon 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Hydronic BackFlow Preventers and AutoFill Valves
BackFlow Preventers from Caleffi, Cash Acme and Watts Hydronic. Use Backflow Preventers and Auto Fill Valves for Hydronic Boiler Heating Systems.
Caleffi Autofill Boiler Feed Valve
Caleffi 553549A automatic filling unit, anti-scale, visual system pressure setting indicator. Complete with manual shutoff valve, strainer and check valve
Caleffi Back Flow Preventers with Dual check continuous pressure backflow preventer with atmospheric vent. NPT Female union connections, threaded
Caleffi Backflow Preventer Auto Fil
Caleffi Backflow Preventer AutoFill Combination 573009A Pre-adjustable automatic filling unit with backflow preventer
Watts Boiler Backflow Preventers
Use Watts Backflow Preventers to keep Boiler Water (with or without antifreeze) from entering domestic (Potable) water supply.
Cash Acme Combo Fill & Backflow
Cash Acme BFAC accurately reduces system pressure down to 14 psi while preventing the back-siphonage of contaminated water into the potable water supply
Cash Acme Backflow Preventers Prevents backflow of contaminated water into potable water supply lines. Ideal for boiler feed lines
Used on boiler supply feed lines to provide make-up water to the boiler. Prevents backflow when supply pressure falls below system pressure.
Cash Acme Boiler Feed Valve A-89C - 22064-0014 to supply water to heating systems when low
Watts Boiler Feed Valves supply water to heating systems when low


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Kindergarten Just Got A Lot Cooler Sublimation Transfer come Ready To Press! Sublimation Transfers can be used to easily create shirts, pillows, mugs, bags, mousepads, or any item that is at least 50% polyester, but 100% will give you the most vivid colors.
Transfers are professionally printed and will give you that High Quality look that will not peel or crack. All transfers are printed with High Resolution designs created by Southern Belle Graphics.
For Pressing Instructions, please click here.
1. Must be AT LEAST 50% Polyester, 100% Polyester will give you the best results.
2. ONLY use White or Light Colored Fabrics.
3. Must have a heat press.
1. WILL NOT work on 100% COTTON shirts!
2. WILL NOT work on Black or Dark Colored Fabrics! The transfer is not opaque and will NOT transfer White. Black or Dark fabrics will not allow the design to show through.
3. WILL NOT work with a home iron.
* * PLEASE NOTE!!! You must have a Heat Press to use these transfers, an iron will not work.
* * Easy to Understand Pressing Instructions will be included with each order.
* * 50% Polyester fabric will give you a Vintage Look. Some fading might occur after washed if 100% Polyester is not used.
* * The colors shown from Sample Pics will be different from the colors on the transfer. Once pressed the colors will be more vivid.
* * You will receive the Sublimation Transfer only, no shirt is provided.
* * Test Swatch will be one of my predesigned images for you to test the quality of the transfers.


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Recently, my colleague Dr. Mark Lau and myself wrote a short post on the UCSD Center for Mindfulness Blog. It describes, in brief, a Buddhist psychological model of how mindfulness exerts its clinical effects, based on the paper mentioned in my last post. You can read the blog post here.
Archive for the 'mindfulness' Category
A Buddhist Psychological Model of Mindfulness
How Does Mindfulness Work?
Interest in mindfulness in the clinical setting continues to grow. My colleagues, Dr. Mark Lau and Brandilyn Willett, and I have recently published a paper in the journal Mindfulness that proposes a detailed model to explain the mechanisms by which mindfulness exerts its clinical effects. You can view an online fulltext version of the paper here.
The Neurobiology of Mindfulness
There have been many exciting advances in the last few years in our understanding of how mindfulness meditation affects both the structure and function of the brain. I want to tell you about 4 studies to explain why mindfulness can be a powerful tool in the treatment of a number of psychiatric disorders.
Structural Brain Changes
Structural changes in the brain can occur as the result of meditation, according a study by Sara Lazar and her group at the Psychiatric Neuroimaging Research Program at Massachusetts General Hospital. Lazar took a group of experienced mindfulness practitioners and a matched control group that had no meditation experience, and they measured the thickness of their cerebral cortex. They found that the parts of the brain involved in self-reflection and empathy were significantly thicker in the meditators than in controls.
In particular, Lazar identified 2 cortical areas where differences in thickness between meditators and non-meditators were particularly striking. These were the right anterior insula (labeled number 1 in the figure above), which is involved in awareness of internal states, and Brodmann area 9/10 (labeled number 2 in the figure above), which is involved in the integration of emotion and cognition. The clinical implication of cortical thickening in these specific brain areas is that increased awareness of internal sensations and improved integration of emotion and cognition may improve how stressful events are handled. They also found that the typical age-related decreases in thickness in Brodman 9/10 area that we see in most brains did not occur in the brians of the meditators!
Functional Brain Changes
The next study I want to tell you about was done by Richard Davidson and his team at the Laboratory for Affective Neuroscience at the University of Wisconsin. To understand this study, I need to first give you some background on how the prefrontal cortex (PFC) is involved in emotion regulation. Each of us tends to have either greater left PFC activity or greater right PFC activity. This is known as asymmetrical prefrontal cortical activation, and the balance between left and right prefrontal cortex is key in emotion regulation.
Studies have shown that people with more left-sided activation tend to be more approach and reward oriented and emotionally positive, whereas people with more right-sided activation tend toward more avoidant and withdrawn and have more negative emotions such as anger, anxiety and depression. This asymmetry is eve npresent at birth and has been found to predict the length of time that it takes ionfants to cry after they are separated from the mothers! Perhaps not surprisingly, in people suffering from depression the finely tuned balance between left and right activation is shifted towards more right sided activation.
What Davidson wanted to know was whether mindfulness practice would shift the brain of the practitioners to having more left-sided prefrontal activation. Davidson found that 8 weeks of mindfulness practice increased left-sided prefrontal activation both at baseline and in response to emotional stimuli. The figure above shows the increase in left sided activation with negative affective stimuli in the meditation group, before the meditation course (Time 1) and 4 months after the course ended (Time 3). This is consistent with other research showing that more leftsided prefrontal activation is associated with more adaptive responses to negative or stressful life events. Davidson's work was the first to show that meditation could bring about this effect. They also observed that this shift towards increased left sided activation was associated with significant reductions in anxiety and negative affect in the meditation group.
I'd like to point out that this study also demonstrated that meditation can affect brain function in a sustained manner. That is, brain changes induced by mindfulness practice, like the shift to left sided activation, continued to be present in the brain between periods of mindfulness practice.
There is another way that increased levels of mindfulness change brain function. Several neurobiological studies have shown that during affect labeling, that is, when we use words to identify the emotion we are feeling, the prefrontal cortex becomes active and downregulates the activity of the amygdala, a region commonly associated with negative affective states. Interestingly, in people suffering from depression, the prefrontal cortex is less able to moderate the activity of the amygdala.
This figure above is from a study done by Creswell and his group at UCLA. They showed that in people with greater mindfulness, the effect of affect labeling is increased, resulting in a greater downregulation of the amygdala (as shown in the figure above) than in those with lower mindfulness. In other words, participants who had greater mindfulness scores at baseline were better able to regulate negative emotions than those with lower mindfulness scores.
Clinical Applications
Mindfulness Based Cognitive Therapy has been shown to decrease depressive relapse rates by almost 50% in the year after MBCT treatmentbra! Let's look at how the functioinal brain changes we have just reviewed might account for this result.
People suffering with depression have an impaired ability to regulate negative mood. Johnstone's research into brain changes that occur with depression highlighted two changes: first, there is counterproductive activation of the right prefrontal cortex, (depressed individuals have the shift to right sided prefrontal cortical activation that we discussed earlier) and secondly, in depression there is upregulation of the amygdala by the left ventromedial prefrontal cortex, rather than the downregulation seen in healthy individuals. So in depression we see a shift to overall right sided prefrontal cortical activation rather than left and upregulation rather than downregulation of the amygdala.
So one of the reasons that mindfulness can be such a powerful tool in treating depression is because it has the potential to reverse the neurobiological changes seen in depression. Mindfulness can shift a more right sided activation to a more left sided activation, and strengthen the functional connectivity between the PFC and the amygdala, allowing the left PFC to more effectively downregulate emotional responses in the amygdala.
Mindfulness Matters - a new blog and website
Welcome to Mindfulness Matters! This website is a place for patients, clinicians and others to learn about and discuss the connections between mindfulness and mental health.
I will be writing about the latest research in mindfulness and neurobiology, as well as sharing related insights from both my clinical and personal practice with mindfulness.
For an overview about what mindfulness is and how it relates to mental health, you can read my article What is Mindfulness?
For more information about my clinical and research activities, you can read my bio.
Please contact me with specific questions or topics you would like to know more about and I will try to address them in the blog.
Thank you for visiting Mindfulness Matters!


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FREE SHIPPING for all orders over $200 Australia Wide. Except Bone Inlay items.
14-day return policy offered. See T&C for details.
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Exquisite chain stitch Abstract Pattern Art Miro Throw Pillow Cushion is hand made on bright vibrant cheerful colours. The abstract qualities of this piece, as well as the juxtaposition of primary colors and pastels of this contemporary cushion cover, create a vibrant point of interest for your decor. The Miro throw pillow cushions are inspired from Joan Miro's constellation series. This abstract pattern art Miro cushion brings consistent strength and a quality of being light-hearted and cheerful living to the room.
It is a perfect abstract throw pillow for your couch or bed. The Miro throw pillow cushion is on Viscose Silk at front and canvas thick cloth with zipper opening at the back, Soft material to touch and feel, easy to vacuum clean.
Cushion Material: 100% Viscose silk at Front and 100% cotton at back.
Size: 45x45cm
*Please note: The colours may vary from the picture due to photography and also monitor colour resolution.
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|45 × 45 cm
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Zeldin tops Demos, will face Bishop this fall
It will be a rematch between Tim Bishop and Lee Zeldin this fall.
State Senator Lee Zeldin defeated George Demos in Tuesday's primary to secure the GOP line in the race for New York's 1st Congressional District seat.
Mr. Zeldin, 34, defeated Mr. Demos with 62 percent of the vote, grabbing 9,654 votes compared to 5,880 for Mr. Demos.
|Lee Zeldin
|George Demos
Mr. Zeldin (R-Shirley) will now prepare to redeem himself on Nov. 4 after his first run for political office six years ago against Congressman Tim Bishop (D-Southampton), in which he earned 41 percent of the vote compared to the incumbent's 58 percent.
Despite the previous results, he said he believes his odds are much better this time around in a midterm election, which national pundits widely agree can often bring fewer Democrats to the polls.
"In 2008, there were certainly factors that were out of our control that are not the same dynamics now," Mr. Zeldin said Wednesday morning. "Barack Obama was much more popular than he is today. People were suffering from [former President George] Bush fatigue and the war in Iraq. And the economy at the end of September really started to get a lot worse."
Personally, he pointed to experience he's since gained at the legislative level — he was elected to the New York State Senate in 2010 — which has brought him more name recognition, a pool of campaign volunteers and better campaign financing.
Despite all that, Mr. Demos outspent Mr. Zeldin throughout the primary campaign at a rate of more than three-to-one, spending over $1.9 million compared to Mr. Zeldin's $580,000.
Mr. Demos — who ran in two previous primaries, in 2010 and 2012 — said he was unsure what the future would hold for him.
"I want to continue to be involved in public service and fight for conservative principles," he said. When asked if he might run again for public office, he said he hadn't decided yet.
A spokesman for Mr. Bishop, Keith Davies, released the following statement after Tuesday's race.
"Lee Zeldin now has a voting record which shows he has far-right positions which are out of the mainstream in Suffolk County. Not only did he oppose the bipartisan SAFE Act which expanded New York's ban on assault weapons, he led a Tea Party rally to denounce it."
Mr. Bishop will be running for his seventh consecutive term after defeating challenger Randy Altschuler in his last two campaigns.


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Dave Pratt Live
Ep. 7
Dave Pratt Live
All Episodes
11/20/2020Ep. 228 New Season of Dave Pratt Live
04/27/2020Ep. 227 Dave Pratt Live returns this Fall.
04/08/2020Ep. 225 WATCH NOW! Chicks Dig DAVE PRATT LIVE! Share some laughs with your friends, and thanks to our sponsors Sagicor Life Insurance Atlas Automotive, Arizona Diamondbacks and Gatorade!
03/25/2020Ep. 224 WATCH NOW! Instant relief, but always in the wrong direction….. DAVE PRATT LIVE!!!
03/11/2020Ep. 223 NEW SHOW!!! DAVE PRATT LIVE! CAUTION: No Dave-ing and Driving!
02/19/2020Ep. 222 NEW SHOW! Watch DAVE PRATT LIVE. A new form of birth control.
02/05/2020Ep. 221 Watch Now!! Today's DAVE PRATT LIVE will crack you up!
01/22/2020Ep. 220 WATCH NOW! All new Dave Pratt LIVE!!! Don't Blow it!
01/08/2020Ep. 219 WATCH NOW!!! Dave Pratt LIVE! The Mayor gets Jugs O' Love from loyal viewers
12/18/2019Ep. 218 Watch Now!! Have a coffee with Dave Pratt LIVE!!
12/04/2019Ep. 217 WATCH NOW!! Alice and Colonel Sanders are not chicken of DAVE PRATT LIVE!!!
11/20/2019Ep. 216 WATCH NOW!! Today's DAVE PRATT LIVE is for all the single ladies!
09/04/2019Ep. 215 WATCH NOW!! On today's Dave Pratt LIVE you choose the punchline!
10/23/2019Ep. 214 Watch NOW!! We bare it ALL on a brand new DAVE PRATT LIVE!
10/09/2019Ep. 213 Watch Now! All new Dave Pratt LIVE!
09/18/2019Ep. 212 All New DAVE PRATT LIVE!! Going into a new season whole hog!
09/04/2019Ep. 210 Watch Dave Pratt Live! (And share some laughs with your friends!)
08/14/2019Ep. 209 WATCH NOW! New Monday Dave Pratt Live!
07/17/2019Ep. 208 NEW SHOW! Chicks Dig DAVE PRATT LIVE!
06/19/2019Ep. 207 Truckin' into the week with DAVE PRATT LIVE!
05/15/2019Ep. 206 HOT DOG!! Watch DAVE PRATT LIVE now!
04/10/2019Ep. 205 NEW SHOW!!! - Watch now. DAVE PRATT LIVE!
03/20/2019Ep. 203 Wednesday's DAVE PRATT LIVE!! As you can see the ratings are in
01/07/2019Ep. 202 DAVE PRATT LIVE! Watch now. Hangin' tough to start the week!
01/03/2019Ep. 201 First Show of 2019!!!! Watch now. DAVE PRATT LIVE! Flying high in 2019
12/21/2018Ep. 200 FRIDAY! Celebrities on DAVE PRATT LIVE! The Kardashians spotted in Arizona!
12/18/2018Ep. 199 PRATT'S PICK OF THE WEEK FROM BERGE MAZDA VOLKSWAGEN!
12/17/2018Ep. 198 MONDAY SHOW! Watch now! Merry Christmas From DAVE PRATT LIVE!
12/08/2018Ep. 197 Weekend Show! DAVE PRATT LIVE! World Summit of Star Worldwide Networks
12/01/2018Ep. 196 WEEKEND SHOW!! Watch now. Free and Brainless Entertainment from DAVE PRATT LIVE!
11/29/2018Ep. 195 PRATT'S PICK OF THE WEEK FROM BERGE MAZDA VOLKSWAGEN!
11/28/2018Ep. 194 Today's Show! DAVE PRATT LIVE warns against snorting VIAGRA
11/14/2018Ep. 193 Newest Show! Dial up DAVE PRATT LIVE!
11/12/2018Ep. 192 MONDAY'S SHOW! Guess who joins DAVE PRATT LIVE?
11/09/2018Ep. 191 FRIDAY'S SHOW!! TIme to set sail for the weekend with DAVE PRATT LIVE!!
11/07/2018Ep. 190 It's a Jeep thing with PRATT'S PICK of the week from Berge Mazda and Berge VW
11/05/2018Ep. 189 MONDAY SHOW! The Sub Culture of DAVE PRATT LIVE!
11/02/2018Ep. 188 FRIDAY'S SHOW. Employee of the Month for DAVE PRATT LIVE!
10/31/2018Ep. 187 Happy Halloween Show from DAVE PRATT LIVE!!!
10/30/2018Ep. 186 Keep on Truckin' with PRATT'S PICK of the week from Berge Mazda and Berge VW
10/23/2018Ep. 184 "The Mayor's" Berge Mazda Pratt Pick of the Week!
10/22/2018Ep. 183 MONDAY'S SHOW!! Royal laughs with DAVE PRATT LIVE! (Share with your friends!)
10/19/2018Ep. 182 FRIDAY'S SHOW!! The new DAVE PRATT LIVE ratings have arrived!!
10/18/2018Ep. 181 The Mayor's favorite cookie! NOMaste Baking Co.
10/17/2018Ep. 180 Pratt's Pick of The Week!! (Berge Bug!)
10/15/2018Ep. 179 MONDAY Show! DAVE PRATT LIVE with medical advice!
10/13/2018Ep. 178 WATCH NOW! Weekend Show. DAVE PRATT LIVE!!
10/11/2018Ep. 177 Who Wants To Drive This Car?
10/10/2018Ep. 176 Wednesday's show! DAVE PRATT LIVE!! We Are Killin' it!!
10/05/2018Ep. 175 Friday's Show! Where we have to bribe to watch DAVE PRATT LIVE!!
10/03/2018Ep. 174 Wednesday's Show! Tips for watching DAVE PRATT LIVE!
10/01/2018Ep. 173 MONDAY's show! DAVE PRATT LIVE is in the neighborhood!
09/28/2018Ep. 172 FRIDAY'S Show! Critic's reviews are in on DAVE PRATT LIVE!
09/26/2018Ep. 171 Wednesday's DAVE PRATT LIVE!! Puddin' his ass in jail!
09/24/2018Ep. 170 Monday's DAVE PRATT LIVE!! We are off to a HOT start!
09/21/2018Ep. 169 FRIDAY'S Show! DAVE PRATT LIVE!! Bringing you the highest form of Education!
09/19/2018Ep. 168 WEDNESDAY'S DAVE PRATT LIVE! Where Everyone is Welcome!
09/17/2018Ep. 167 MONDAY'S show. DAVE PRATT LIVE!
09/14/2018Ep. 166 FRIDAY'S Show! DAVE PRATT LIVE!! On today's show we answer the important questions
09/13/2018Ep. 165 Throwback Thursday, Hurricane Flo and Thunder Buddies.
09/12/2018Ep. 164 WEDNESDAY'S SHOW!! DAVE PRATT LIVE is now legal for EVERYONE!!!
09/10/2018Ep. 163 MONDAY'S SHOW! Serena's reaction from being forced to watch DAVE PRATT LIVE!!
09/09/2018Ep. 162 THURSDAY'S DAVE PRATT LIVE!!! Watch Now!
09/04/2018Ep. 161 Get a Head on TODAY'S DAVE PRATT LIVE!! Thanks to Sagicor Life Insurance for sponsoring our show!
08/29/2018Ep. 160 Today's DAVE PRATT LIVE!! Star Worldwide Network's host and New York Times Best selling author Christy Whitman releases her new book Quantum Success!
08/27/2018Ep. 159 JOHN MCCAIN TRIBUTE. "The Mayor" shares some personal friendship stories on DAVE PRATT LIVE!
08/24/2018Ep. 158 WEEKEND SHOW! Dave consoles the puppets still hanging on to AM-FM Radio.
08/22/2018Ep. 157 WEDNESDAY'S SHOW!! DAVE PRATT LIVE!! BELFIE???? Waffle on wheels and chess master Pratt!
08/20/2018Ep. 156 MONDAY'S SHOW!! DAVE PRATT LIVE!! Pratt explains Crazy Rich Asians and disses MTV Video Music Awards Dave's celebrity Berge VW. Meadowlark Lemon
08/20/2018Ep. 155 PRATT WITH GREG KIHN
08/17/2018Ep. 154 FRIDAY'S SHOW! DAVE PRATT LIVE!! Mike Reno from LOVERBOY, The Great noodle robbery, The Mayors favorite hotel pick!
08/17/2018Ep. 153 PRATT WITH MIKE RENO OF LOVERBOY
08/15/2018Ep. 152 WEDNESDAY'S SHOW!! DAVE PRATT LIVE!! Would this be considered Hump Day?
08/13/2018Ep. 151 MONDAY'S SHOW!! DAVE PRATT LIVE!! Proud of your High School Photos? Dave's Meteor Shower Party and Too much for Tiger?
08/10/2018Ep. 150 FRIDAY'S SHOW!! DAVE PRATT LIVE!!
08/09/2018Ep. 149 THURSDAY'S SHOW!! DAVE PRATT LIVE! Pratt rants about weather reporting. Drinking with the Mighty Ducks and Rum Donkeys in Hell's Kitchen.
08/06/2018Ep. 148 MONDAY'S SHOW! DAVE PRATT LIVE!! Horneytown Road. Dave's Café. Splash Sticks. Costco Brawlers and Goodbye Ms. Garrett.
08/03/2018Ep. 147 FRIDAY'S SHOW! DAVE PRATT LIVE! Our favorite new recipe. Who is gettin' a Whoopin? Everyone loves a little Doaner.
08/01/2018Ep. 146 WEDNESDAY'S SHOW! DAVE PRATT LIVE! Beware of the wife. Dave's cool off tip of the day. Armor Piercing Straws and one SEXY producer!
07/31/2018Ep. 145 TUESDAYS SHOW! DAVE PRATT LIVE!! Did they really think this through?...
07/30/2018Ep. 144 MONDAY SHOW! DAVE PRATT LIVE! Are you easily offended? Loser of the Day and what's in Dave's wallet?
07/27/2018Ep. 143 QUESTION OF THE DAY, TEMPS STILL HOT and WHAT IS A LUG NUT?
07/25/2018Ep. 142 Wheel of Fortune, Selfies that kill and Dave is the 7th Brady Kid
07/24/2018Ep. 141 How Do You Feel About The Heat? Vegas Street Performers, Shout outs, and Ethel gets a how to use the internet lesson
07/23/2018Ep. 140 Stupid Hikers, More Shark Week and Chick Filet Baby!
07/20/2018Ep. 139 DUCT TAPE BIKINIS, HOLE IN ONE, NFL PROTEST SEASON, HAPPY BIRTHDAY KYLE PRATT!!
07/18/2018Ep. 138 Coffee and Kardashians, Croc lovers and Grandma on speeding
07/17/2018Ep. 137 A stuck Swift, false Doctors, Naughty Papa, and a thankful Mayor
07/16/2018Ep. 136 Firetruck jacked, Beaches, Trump and Putin, Jack in the Box, and cavemen!
07/16/2018Ep. 135 Radio: Football is just around the corner
07/13/2018Ep. 134 MORE THAN A FEELIN....
07/11/2018Ep. 133 Towel stealing Rio
07/10/2018Ep. 132 Monsoons are back!
07/09/2018Ep. 131 A bunch of Bull (runnings)
07/09/2018Ep. 130 Dave Pratt LIVE Radio Show - Cooling off to 105
07/06/2018Ep. 129 Hot temps in the Valley
07/05/2018Ep. 128 Lori from Right Way Roofing Stops by.
07/04/2018Ep. 127 Fireworks, Shout outs, and Darth Vader! Happy 4th of July!!
07/03/2018Ep. 126 From the Bay City Rollers to Topless Car Washes
07/02/2018Ep. 125 Ten minutes and we'll give you a few laughs
06/27/2018Ep. 124 Gas Prices
06/12/2018Ep. 123 Roof Repair, Replacement & Installation By Right Way Roofing
06/11/2018Ep. 122 The Tony Awards
06/04/2018Ep. 121 Summer Vacation
05/29/2018Ep. 120 Predictions 15 years Ago
05/21/2018Ep. 119 Memorial Day
05/14/2018Ep. 118 Royal wedding
05/07/2018Ep. 117 Triple Crown?
04/30/2018Ep. 116 May is here
04/23/2018Ep. 115 Summer Jobs
04/16/2018Ep. 114 Rob's Not allowed on Social Media
04/09/2018Ep. 113 Yellow Lights
04/02/2018Ep. 112 April is here
03/27/2018Ep. 111 Opening Day
03/19/2018Ep. 110 Upsets!
03/12/2018Ep. 109 The Selfie Station
03/05/2018Ep. 108 Oscars
02/26/2018Ep. 107 Amnesty Box
02/19/2018Ep. 106 Daytona 500
02/12/2018Ep. 105 Winter Olympics In Full Swing
02/05/2018Ep. 104 Minus 8 Degrees
01/30/2018Ep. 103 THE PHOENIX OPEN, SUPERBOWL WEEK, WINTER OLYMPICS
01/23/2018Ep. 102 NEIL DIAMOND, Super Bowl, The PERFECT WOMAN
01/18/2018Ep. 101 Joint Hockey
01/08/2018Ep. 100 Clean your Desk!
01/02/2018Ep. 99 FIRST SHOW OF 2018!!
12/11/2017Ep. 98 HOLIDAY PARTY…….TEAM USA ........CHRISTMAS TOWNS
12/06/2017Ep. 97 Directions
12/04/2017Ep. 96 Waffle House
11/30/2017Ep. 95 "Journalism"
11/27/2017Ep. 94 7-ELEVEN , THANK YOU'S, BALLOON RIDE, AND MORE
11/20/2017Ep. 93 From pancakes to pornstars!
11/13/2017Ep. 92 Christmas Music, AZ license Plates, Dating Formulas
11/09/2017Ep. 91 Dave Pratt is Thankful 11-9-17
11/07/2017Ep. 90 Dave Pratt's THANKFUL LIST!
11/06/2017Ep. 89 Godzilla, Murder on the Orient Express, Bruno Mars and more
11/03/2017Ep. 88 Cowboy Dave!
11/02/2017Ep. 87 Dave's Baby Announcement
11/01/2017Ep. 86 Dave Pratt's Thankful List 11-1-17
10/31/2017Ep. 85 Dave Pratt's Halloween Thankful List
10/30/2017Ep. 84 An Excuse
10/23/2017Ep. 83 Halloween party, Harvey Weinstein, and city to city rocket service
10/16/2017Ep. 82 Halloween Candy
10/09/2017Ep. 81 Pizza Pizza
10/02/2017Ep. 80 October
09/27/2017Ep. 79 Kinda Corney
09/25/2017Ep. 78 Titanic Price
09/18/2017Ep. 77 Monday Night Football
09/11/2017Ep. 76 A day without Football?
09/05/2017Ep. 75 Football Season
08/28/2017Ep. 74 300 Million
08/22/2017Ep. 73 Ding Your Dong
08/14/2017Ep. 72 Helicopter Ride
08/07/2017Ep. 71 Live from Hell
07/31/2017Ep. 70 Elevator Talk
07/31/2017Ep. 69 Ericka's "Augmentation "
07/24/2017Ep. 68 Jump the Shark
07/10/2017Ep. 67 Crappy Coffee
07/03/2017Ep. 66 4th of July Week
06/26/2017Ep. 65 CONTINUING THE 30TH ANNIVERSARY OF TOP GUN!
06/19/2017Ep. 64 120 Degrees
06/12/2017Ep. 63 ADAM WEST, TIGER WOODS, and PUERTO RICO
06/05/2017Ep. 62 Busted by Facebook
06/01/2017Ep. 61 What's Bugging Dave? Dunkin' Doughnuts
05/30/2017Ep. 60 Its a Pirate Life for Me.
05/25/2017Ep. 59 Dave Pratt Live with Hailey and Drones
05/19/2017Ep. 58 ERICKA'S BOYFRIEND
05/22/2017Ep. 57 Memorial Day Travels
05/17/2017Ep. 56 Dave Pratt Live with Dave Burns
05/15/2017Ep. 55 Marlins Fan
05/11/2017Ep. 54 Dave Pratt Live with Hailey Frances
05/10/2017Ep. 53 What's Bugging Dave? May 10th 2017
05/09/2017Ep. 52 Those Bears
05/09/2017Ep. 51 Banned from the Ukraine
05/07/2017Ep. 50 Sean Hoy Grand Marshall of Cinco de Mayo Parade
05/04/2017Ep. 49 Sammy Goes To College-The Mayor Preps Him
05/01/2017Ep. 48 Long Shot odds
04/29/2017Ep. 47 These new business cards. I got a million of 'em. See?
04/24/2017Ep. 46 Pratt Cam On The Streets - Phoenix Zoo
04/24/2017Ep. 45 Happy Days
04/20/2017Ep. 44 Dave Pratt Live-How The Mystery Envelope Works
04/18/2017Ep. 43 Dave Pratt Live with Karynda Kearns and Driveby Blessings
04/17/2017Ep. 42 Taxes
04/14/2017Ep. 41 New Star Wars Trailer is here
04/12/2017Ep. 40 Would You Rather with Ericka
04/12/2017Ep. 39 Dave Pratt Live with Scottsdale Center for Women's Health
04/10/2017Ep. 38 Figuring it out
04/08/2017Ep. 37 Pratt Cam - National Beer Day!
04/04/2017Ep. 36 Dave Pratt Live-The Fire Alarm Drill Catches Producer In The....
04/03/2017Ep. 35 Final 4
04/01/2017Ep. 34 Pratt Cam Final 4 Baby!
03/20/2017Ep. 33 In honor of Star Worldwide returning to comicon
03/27/2017Ep. 32 Dave Pratt Live 200th Show
03/27/2017Ep. 31 Final 4 coming to Phoenix
03/24/2017Ep. 30 A big thank you to our loyal viewers on Dave Pratt LIVE's 200th Episode on CW 6
03/22/2017Ep. 29 Would you rather fight 1 Horse-Sized Duck or 100 Duck-Sized Horses?
03/20/2017Ep. 28 Chuck Berry Tribute
12/01/2016Ep. 27 Giant Chicken
03/17/2017Ep. 26 Dave Pratt LIVE on St. Patty's day With Sean Hoy
03/14/2017Ep. 25 Dave Pratt Live with Girl Scout Council
03/13/2017Ep. 24 Beauty and the Beast
02/15/2017Ep. 23 You are the Star
03/06/2017Ep. 22 Spring Break 2017
02/28/2017Ep. 21 Dave Pratt LIVE and Phoenix Magazine at the RV show
02/27/2017Ep. 20 Really that's the best that Hollywood has?
02/23/2017Ep. 19 Dave Pratt Live on the Oscars
02/23/2017Ep. 18 Dentist Trip who needs gas
02/21/2017Ep. 17 Gas Station woes
02/20/2017Ep. 16 Meet The Mayor-Clayton Conatzer
02/20/2017Ep. 15 Meet The Mayor with Guest Judy Schriener
02/20/2017Ep. 14 Dave Pratt Live
02/13/2017Ep. 13 Debut of The Pratt Cam
02/13/2017Ep. 12 Dave Pratt Live
01/30/2017Ep. 11
01/23/2017Ep. 10
01/16/2017Ep. 9
01/09/2017Ep. 8
01/03/2017Ep. 7
12/19/2016Ep. 6
12/12/2016Ep. 5
11/28/2016Ep. 4


text:
Earn up to 150 Puritan's Perks points. Learn More
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Part of the ginger family, Turmeric has been used for centuries in Asian cultures for its natural healthy benefits.** Among the active ingredients in this ancient root are curcuminoids—most notably curcumin—plant-based antioxidants that help cells defend against damaging free radicals.**
By providing potent antioxidant support, Puritan's Pride Turmeric Curcumin herbal supplements aid in your body's overall well-being.**
About Puritan's Pride
For more than 45 years, Puritan's Pride has helped families achieve a lifestyle of wellness. Our vitamins and supplements are made with care from the highest quality ingredients. They are tested or inspected as many as 15 times throughout the manufacturing process. That's why you can shop with confidence. We take pride in our products and helping customers feel their best.
Supplement Facts
|Serving Size 1 Capsule
|Amount Per Serving
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|800 mg *
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No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.


text:
Primary location
B-1050 Brussels
Raphaël De Coninck
Vice President
Dr. Raphaël De Coninck is a Vice President at Charles River Associates (CRA), where he heads the Brussels office. Raphaël has provided expert economic evidence and testimony in numerous high profile cases covering antitrust and competition matters (including over 60 mergers and 20 "Phase II" merger investigations, abuses of dominance and cartels), intellectual property and damages quantification. He has advised clients in litigation and regulatory proceedings in front of the European Commission and of national courts and authorities, primarily in Belgium, France, the Netherlands, the United Kingdom, Spain and Switzerland.
Raphaël's experience spans a wide range of products and industries, including pharmaceuticals, IT, consumer products and retail, transport, telecoms, energy, basic industries, financial services, media and entertainment. While at CRA, he has worked for clients such as Universal Music Group, Google, Dolby, Pfizer, Novartis, Mylan, Baxter, Abbott, GE, Virgin Atlantic, Danone, Henkel, L'Oréal, ABF, Ahold Delhaize, FIFA, Cable Europe, Canal+, SFR, Deutsche Bank, JP Morgan and the European Commission.
Prior to joining CRA, Raphaël was a member of DG Competition's chief economist team at the European Commission. He has published numerous articles on the economics of competition and contributed to major competition policy initiatives, including the European Commission's Best Practices for Economic Submissions and Data Collection in Merger and Antitrust Cases, and the European Commission's Practical Guide on the Quantification of Antitrust Damages.
Raphaël received a PhD in economics from the University of Chicago, and degrees in law and in economics from the University of Liège, Belgium. He previously lectured on law and economics at the University of Chicago, held an academic position at New York University School of Law, and is currently teaching on competition policy at the Free University of Brussels (ULB) and at the Brussels School of Competition (BSC).
- Ph.D. Economics, University of Chicago
- M.A. Economics, University of Chicago
- Licence Law, University of Liège
- Licence Economics, University of Liège


text:
District Department of Transportation (DDOT) identifies and develops the transportation related projects for the District of Columbia Capital Improvement Program (CIP) and the annual Capital Budget. The CIP uses these recommendations as the basis for projects to include in the Transportation Improvement Plan (TIP) and Financially Constrained Long-Range Plan (CLRP). These documents, compiled by the Washington Metropolitan Council of Governments (WMCOG), provide an overview of the transportation projects desired and planned for construction over a period of twenty years.
Capital Improvement Program (CIP) and Capital Budget
The District of Columbia's Capital Improvement Program (CIP), the "Capital Program," comprises the financing, acquisition, development and implementation of permanent improvement projects for the District's fixed assets. Such assets generally have a useful life exceeding three years and cost more than $250,000. The CIP document is a comprehensive, annually updated, six-year plan for the development, modernization or replacement of city-owned facilities and infrastructure and can be viewed on the website for the Office of the Chief Financial Officer. The CIP consists of the appropriated budget authority request for the upcoming fiscal year and projected funding/expenditure plans for the following five years. In most instances, the major portion of capital authority goes toward improvements or applicable activities associated with streets, bridges, government facilities, public schools, and recreational projects.
Transportation Improvement Program (TIP)
The Transportation Improvement Plan (TIP) is prepared each year by the National Capital Region Transportation Planning Board (TPB), which is the designated metropolitan planning organization for the Washington region. As a product of the urban transportation planning process, it outlines the staged development of the area's financially-constrained Long-Range Transportation Plan (CLRP), with priority projects selected for programming by the TPB, the states, and the transit agencies presented in the first year of the six-year program. The TIP is updated by state, regional and local transportation agencies each year.
The Purpose of TIP
Expresses the region-wide intent to implement specific facilities and projects during the upcoming six-year period.
Provides a medium for local elected officials, agency staffs, and interested members of the public to review and comment on the priorities assigned to the selected projects.
Satisfies one of the requirements of FHWA and FTA for the continuing transportation planning process of this region (necessary for certification to insure continued federal financial assistance for Washington area transportation improvements).
Establishes eligibility for federal funding for those projects selected for implementation during the first program year, known as the Annual Element of the program.
This TIP is a multi-modal listing of the public transit, highway and HOV, bicycle and pedestrian improvements as well as ridesharing programs and transportation emission reduction measures for which the obligation of funds has been programmed. It documents the cost, implementation phasing, sources and types of funds, and describes each project included in the program.
Constrained Long Range Plan (CLRP)
The Constrained Long-Range Plan (CLRP) for the National Capital Region identifies the capital improvements, studies, actions and strategies that the region proposes to carry out by the year 2020. It is "financially constrained" to include only projects that the region can afford to build and operate during a 25-year period. The plan is updated at least every three years. The document summarizes regional plans and programs. Major improvements, studies, and actions included in the plan are described in this document. However, detailed descriptions of these major projects, as well as descriptions of small-scale projects not shown here, are contained in separate supplementary documents.
The plan addresses a number of other federal requirements, including meeting national air quality standards, contributing to annual emissions reductions, and considering the relationship between land use and transportation. Greatly expanded opportunities for interested citizens and organizations to participate in each stage of the plan's development were provided.


text:
ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at email@example.com.
- Angell, Charles
- 1 Arizona State University
- 1 Chakraborty, Manas
- 1 Levitus, Marcia
- 1 Lindsay, Stuart
- 1 Public
- Chemistry
- Biophysics
- 1 Protein oligomerization
- 1 Rubisco Activase
- Reverse Fountain Cytoplasmic Streaming in Rhizopus Oryzae
- Diné Research Practices and Protocols: An Intersectional Paradigm Incorporating Indigenous Feminism, Critical Indigenous Research Methodologies and Diné Knowledge Systems
- Developing an Augmented Reality Solution for Mapping Underground Infrastructure
- Characterization of 2D Human Ankle Stiffness during Postural Balance and Walking for Robot-aided Ankle Rehabilitation
- Using Molecular, Cellular and Bioengineering Approaches Towards Understanding Muscle Stem Cell Biology
Ribulose-1, 5-bisphosphate carboxylase oxygenase, commonly known as RuBisCO, is an enzyme involved in carbon fixation in photosynthetic organisms. The enzyme is subject to a mechanism-based deactivation during its catalytic cycle. RuBisCO activase (Rca), an ancillary enzyme belonging to the AAA+ family of the ATP-ases, rescues RuBisCO by facilitating the removal of the tightly bound sugar phosphates from the active sites of RuBisCO. In this work, we investigated the ATP/ADP dependent oligomerization equilibrium of fluorescently tagged Rca for a wide range of concentrations using fluorescence correlation spectroscopy. Results show that in the presence of ADP-Mg2+, the oligomerization state of Rca gradually …
- Contributors
- Chakraborty, Manas, Levitus, Marcia, Angell, Charles, et al.
- Created Date
- 2014


text:
By: Lorillia Brown-Phillips, The Money Mentor, Your Black World
The Facebook stock buying frenzy began on Friday May 18, 2012, the company's initial public offering (IPO) stock purchase price opened at $38 for the general public. Everyone is talking about buying Facebook stock with the hopes of riding the stock tidal wave of wealth. While buying a company's stock can be a great asset class to have as part of your investment portfolio, many novice investors need to be cautious before joining the masses of online stock purchasers. If you are considering opening a stock account online to begin investing, here are 6 tips to consider before you make your first stock purchase.
- Understand Risk tolerance – an investor's risk tolerance determines if an investor is a conservative, moderate or an aggressive investor. Knowing your risk tolerance is important before you make any type of investment purchase, conservative investors tend to be risk averse to stock buying, where as moderate and aggressive investors are risk seekers. Always check to see if the online broker's website has a risk tolerance measuring questionnaire.
- Commission & Transaction fees – find out what are the transaction fees being charged to place a stock order. Many stock trading websites fees range from 4.95 to 9.95 the price can be based on the day of the week, the buying frequency or type of investment selection.
- Minimums – do the online broker require an upfront deposit to place an order, make sure minimums are not required to get started.
- Customer service – what type of interaction is available to answer your questions; are there live agents to take your calls, live chat sessions or only a FAQ page. Keep in mind customer service can only answer questions regarding the online trading plat form; many customer service agents that work for online brokers are not license professionals. This means they cannot give customers advice on their investments.
- Investment selection – what type of investments do the online broker provide for purchasing, it's important to know is the website for only buying EFTs, stocks, mutual funds, or a variety of investments.
- Oversight affiliation –is the online servicer a member of SIPC®, which is the Securities Investor Protection Corporation or FINRA, Financial Industry Regulatory Authority. Online brokers usually include their affiliations within the footer of the website.
About the Author:
Lorillia Brown-Phillips is a Financial Literacy Educator and Author of "Jump Start Your Credit: How to Negotiate and Settled Your Debts in 10 Steps", subscribe to her blog at: www.yourmoneymentor.com


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123 HP Officejet Pro 8031 Airprint Setup
123 HP Officejet Pro 8031 AirPrint Setup supports the feature of AirPrint which enables you to print wirelessly with your iOS devices. AirPrint 123 HP Officejet Pro 8031 is a mobile printing solution that comes inbuilt in the Apple iOS devices with v4.2 or later mobile operating systems. Easy printing with via a wireless network, your iPad, iPod, iPhone.
Make sure that your Apple iOS device and your printer support the 123 HP Officejet Pro 8031 Apple AirPrint feature. Check that your iOS device and your Printer both are connected to the same network connection.
123 HP Officejet Pro 8031 Set up the Wireless Connection
- Check that your printer is not connected via USB or an Ethernet connection (the printer cannot be connected wirelessly when connected to USB or Ethernet)
- From the Control panel display select the 'Setup' (Network setup)
- Go to the Wireless connection option.
- Go to the menu
- Select the Wireless setup wizard option.
- Now follow the instructions on your screen and complete the AirPrint setup.
- Try to print
If you are still facing the problem then try the below-given method to print with AirPrint.
Need help ? Call For Technical Support Call Toll Free 1-819-716-0730
123 HP Officejet Pro 8031 Set up WiFi Direct
You can connect your printer directly to your iOS device via WiFi direct or HP direct connection. Make sure your printer is On and you WiFi direct is On. (You can see the icon on the panel display if the WiFi direct is switched On)
- Switch On the WiFi direct from your printer control panel.
- On your iOS device go to the Settings menu and then go to WiFi settings.
- Now select your printer name from the list. Make sure that the printer name begins with 'DIRECT'.
- If you are asked to enter the password then, the default password is '12345678'.
- Now try to print by opening the photo or document on your iOS device.
- Click the Share icon from the display menu option.
- Now touch the Print icon to print the file or doc.
- Select the name of your printer from the list.
- Go to the 'options' menu if you want to alter the settings (orientation, page type, contrast etc) according to your requirement.
- Select the number of copies you want to print and then click Print.
Disclaimer: 123-hp-com.club is an independent service provider of tech support for third-party products. Any use of third party trademarks, brand names, product, and services is only for reference and to furnish information. If your product is covered by warranty, the support service may be available for free from the manufacturer. We disclaim any ownership in, right to, affiliation with, or endorsement by unless stated. Users are advised to review our policies before using our Website.