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Penny Arcade
PAX events will host "Diversity Lounge" spaces
Penny Arcade Expo events will in future include a space called the Roll for Diversity Hub and Lounge, designed as "a resource for PAX Attendees to find information related to issues surrounding women, LGBTQ, people of colour, disabled people, and mental health issues in gaming".
Penny Arcade headlines
PAX Australia 2014 dated, moving to Melbourne Convention & Exhibition Centre
PAX Australia 2014 will run October 31 through November 2, and will remain in Melbourne, although in the larger venue.
Penny Arcade's On the Rain-Slick Precipice of Darkness 4 teaser trailer teases
Penny Arcade's On the Rain-Slick Precipice of Darkness 4 has a new teaser trailer available. The Zeboyd Games episode will launch on PC and Xbox Live Indie Games this spring for 400 MS Points, and you can watch the trailer below. Thanks, Joystiq.
Penny Arcade's On the Rain-Slick Precipice of Darkness 4 is less linear, has more strategy options
Zeboyd Games has said Penny Arcade's On the Rain-Slick Precipice of Darkness 4 will be less linear with more secrets and "secondary routes to the main dungeons," said the firm's Robert Boyd in an interview conducted with IGN. Boyd said a number of "adjustments, both small and not so small," have also been made so […]
PAX Australia issues new round of ticketing
PAX Australia has expanded its capacity in response to popular demand, securing a new exhibition space and issuing more tickets. Although individual day passes were still available, Saturday was completely sold out, making it difficult for those hoping to attend the whole show to grab tickets. The new Saturday passes are already running low so […]
PAX Australia 2013 social sites open
Keen on checking out PAX Australia when Penny Arcade's famous expo heads down under next year? Organisers have set up a Facebook and Twitter page to help hopeful attendees track updates. Details like date, venue and even host city are still to be announced – hell, PAX Australia was announced just a few weeks ago […]
PAX 2013 to last an extra day, event heading to Australia
PAX is coming to Australia next year, Penny Arcade's Mike Krahulik and Jerry Holkins confirmed today. It was also announced PAX Prime would last for four days instead of three next year. The Penny Arcade fellas are also considering a UK event as well, but there is nothing to announce on that end at present. […]
Free DLC for Penny Arcade Adventures 3 due during PAX
Expect an expansion for Penny Arcade Adventures: On the Rain-Slick Precipice of Darkness 3 around the end of next month.
Penny Arcade considering third PAX in Austin
During a panel at San Diego Comic Con, as reported by Gamespot, Penny Arcade's Mike "Gabe" Krahulik told the audience that the company is "aggressively exploring a third PAX" close to Austin, Texas. Austin already hosts a number of gaming events and is something of a development hotseat; a local event would join PAX Prime […]
Penny Arcade seeks crowdfunding to go ad free
Gaming culture webcomic Penny Arcade has launched a Kickstarter with no tangible rewards, instead giving readers the opportunity to pay to keep advertising off the site.
Penny Arcade Adventures 3 delayed
The PC version of Penny Arcade Adventures: On the Rain-Slick Precipice of Darkness 3 is due on July 25 – not July 10 as previously reported, apparently – but the Xbox Live Indie Games launch has been pushed back. Write Jerry "Tycho" Holkins confirmed the game failed community peer review due to a crash error […]
PAX Prime registration open next week
With PAX East done and dusted, Penny Arcade has announced the first details of PAX Prime ahead of this year's Seattle event. The Washington State Convention Center is playing host again, but some events will be spread across nearby venues – the Annex, Paramount, Seattle Sheraton and Grand Hyatt, for example. Registration opened temporarily, but […]
Less than 1,000 PAX East badges remain for April 7
PAX East organizers have tweeted that there are less than 1,000 badges available for Saturday, so if you are planning on attending, you need to hurry up and get your badge. PAX East runs April 6-8 at the Boston Convention and Exhibition Center. Last year, 69,500 people attended the weekend event, which this year happens, […]
PAX East stays in Boston until 2023 under new deal
Penny Arcade and MCCA (Massachusetts Convention Center Authority) have announced PAX East will stay at the MCC for the next ten years up until 2023. The new deal will mean the Massachusetts Digital Games Institute (MassDiGI) will get $325,000 each year the convention is held as part of the new deal to promote the industry's […]
Ex-Ars Technica editor joins Penny Arcade
Ars Technica gaming editor Ben Kuchera has bid farewell to the site in favour of a new role at Penny Arcade. Although details are yet to be locked down, it appears the site, which harbours a solid community and runs Child's Play in addition to the eponymous comic, will soon play host to a games […]
Avenger creators donate $10,000 to Child's Play
N-Control, creators of the Avenger, an external adapter which houses an Xbox 360 controller boatsing the ability to improve reaction time and more fluid movements, has donated $10,000 to Child's Play, and has pledged to donate $50,000 worth of Avenger accessories should the charity "find a need for it" and plans to continue donating to […]
Child's Play raised over $3.5 million in 2011
Penny Arcade's Child's Play charity raised a record-breaking $3,512,345 over 2011. Project manager Jamie Dillon praised the efforts of independent fundraising initiatives for the scheme's annual growth; the charity recently passed a $10 million milestone. Child's Play provides games and toys to hospitalised kids, which studies have linked with increased recovery rates. Well done to […]
Child's Play hits $1.5 million in donations for 2011
Child's Play has hit reached $1.5 million in donations for this year, the charity has said, with an aim to hit $2 million by the end of the year still on. The group, formed by Penny Arcade, has made $10 million since it was created in 2003. The main aim of the charity has been […]
Tuesday Shorts: Penny Arcade, UC3, King Arthur II, Teen brains on games
Below you will find a list of newsworthy snippets for your brain, including information on: Uncharted 3 skins, a curfew for online gaming, an MMO about The Mummy, and more.
Wednesday Shorts II: Tales of Xillia, Spiral Knights, Cthulhu, LBP2, Persona 3
I am running out of quirky, esoteric ways to insert an off the wall header image in these shorts posts, so, today I have included one I took of a Hummingbird Moth visiting my batch of flowers on the deck. Shorts are below.
Page 1
Penny Arcade latest
PAX Australia 2014 dated, moving to Melbourne Convention & Exhibition Centre
Penny Arcade's On the Rain-Slick Precipice of Darkness 4 teaser trailer teases
Penny Arcade's On the Rain-Slick Precipice of Darkness 4 is less linear, has more strategy options
Tuesday Shorts: Penny Arcade, UC3, King Arthur II, Teen brains on games
Wednesday Shorts II: Tales of Xillia, Spiral Knights, Cthulhu, LBP2, Persona 3
Friday Shorts II: Mortal Kombat retrospective, Kevin Butler, Penny Arcade, Ultima
PAX East 2011 schedule now online, RAGE and Amalur demos confirmed
Hothead explains why it won't be making a third Penny Arcade Adventures game
Gamers poll more than $2 million for Child's Play's coffers in 2010


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Tag: spammers
IP Block Lists
May 30, 2017 - IT Cost Savings - by rwolf - No Comments
There are many ways to protect your network. One of the many ways EITS works to protect their clients is with a "honey pot" the unsuspecting hacker or hacker bot finds. They or their mechanisms try to hack any number of services (mail, ftp, ssh, etc) which we detect then […]Read More

subset: commoncrawl


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To "celebrate" Data Privacy Day today, both Google and Twitter issued transparency reports, detailing how often they comply with government requests for information about users. In the United States, Google said it provided some or all requested information 88 percent of the time, while Twitter -- which says it prizes users' privacy -- did so 69 percent of the time.
Those numbers seem shockingly high, but in Twitter's case at least, privacy advocates at the Electronic Frontier Foundation said they didn't blame the social network for complying with the law. And, the EFF added, Twitter's new transparency report should be a "model" for the Internet industry.
CNET wants to know what you think. Are these numbers outrageous? Or are Google and Twitter -- and other Internet companies -- just doing what the law requires them to do?


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Canberra security company M5 Networks has been acquired by US defence contractor Northrop Grumman.
Terms of the deal haven't been disclosed, but Northrop Grumman says "The acquisition is not material to Northrop Grumman's 2012 financial outlook" which means it is unlikely to involve colossal sums. M5's team will remain in place and the company will retain its identity.
The acquisition is being positioned as a beach head for Northrop Grumman in Australia, with a statement saying it "… enhances our ability to provide innovative, agile and proven cybersecurity and communication solutions to Australian customers," according to Wes Bush, Northrop Grumman chairman, chief executive officer and president.
Canned quotes from M5 managing director Matthew Wilson support the beach head positioning, as he says "We expect that as part of Northrop Grumman, our customers also will benefit from the cybersecurity leadership and extensive resources that Northrop Grumman can bring to M5 Network Security and its employees.
We suspect the US company also like the looks of M5's secure comms hardware, which could be just the thing for some of its customers. ®


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The research report titled Mechanical Ventilators analyses the performance of the Mechanical Ventilators market the world, at present and historically, and makes future projections based on the result of the evaluation.The Mechanical Ventilators market is expected to extend at Compounded Anal Growth Rate (CAGR) of +10% throughout the forecasted period 2017 to 2022.
The report proposes the in-depth analysis of the Mechanical Ventilators market across different industry uprights and regions. This market is segmented over the world wide geographical regions. While the rate of threats are growing and evolving, organizations are demanding more security, efficiency and flexibility from their team. There arem any solutions on the basis of deployment and flexibility has been provided to fulfill these requirements and teams need more flexibility. The global Mechanical Ventilators market is a highly fragmented, niche market with the existence of a limited number of vendors.
Market providers compete considering the price, innovations, reputation, promotion, and service, distribution. There are chances of large players in the Mechanical Ventilators market to acquire small vendors with advance solutions as the market is still in it progressing and developing stage.
The study of the competitive landscape of Mechanical Ventilators market gives perception into the company profiles, current developments, financial status, mergers and gains, and the SWOT analysis. This research report will give the beginners the complete market scenario for making informative decisions on this market project.
Request For Sample Report @ https://www.fiormarkets.com/report-detail/145785/request-sample
For the largest market share in the prior years, the Mechanical Ventilators has been accounted, and are also expected to influencing the market over the forecast period as well.
The Mechanical Ventilators market report gives the different factors that can affect the industry such as economic impact. The competition of manufacturers on the basis of production, revenue by region, supply, consumption, import and export, price trend by type has presented in this report.
The report also covers the global Mechanical Ventilators market analysis by application, and manufacturing cost analysis. It also provides analysis of industrial chain, sourcing strategy and downstream buyers marketing Strategy, distributors/traders, and market effect factors.
The report also provides information about the fresh advancements of key players and their product price and picture. The business and financial overview of major companies are also discussed in the report. This information is beneficial for both established and beginners in the Mechanical Ventilators market.


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Welcome to USA FIT Salt Lake! We are a group of training partners and friends preparing together for the Huntsville Marathon and Half marathon on September 15th, 2018. Even if you've never run a step before, training with our group will help you conquer mental and physical barriers you never thought possible.
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Blue Goose offers 24 hour locksmith & emergency services in Boston – car key, auto locksmith, re-key, locks change, lockout rescue and more. Call now!
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Kle på Eve
Navn:Eve Jihan Jeffers
Bursdag: November 10, 1978
Eve was ranked #46 on VH1's 50 Greatest Hip Hop Artists. She was the only female artist signed to the Ruff Ryders label, after splitting from Ruff Ryders in 2004 she signed on to Dr. Dre's label. She starred in her self-titled television show ("Eve") and was the Co-Executive Producer from 2003-2006.


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New restaurant will offer great food at reasonable prices.
YREKA – A new family restaurant is under construction in Yreka and will be opening its doors this fall. Siskiyou Roadhouse owners promise that it will offer fresh food at affordable prices – all in a warm and inviting ambiance.
Honest John's Landscaping owners John and Lauren Kennedy are teaming up with Brian and Nanette Kische to open the new eatery.
The Kennedys owned and operated Yreka Drive Thru, now Gold Rush Burgers, for several years before selling it in 2005.
John Kennedy and the co-owners decided to build and open Siskiyou Roadhouse, he said, to provide a quality yet relaxed restaurant environment in an area that he described as having limited dining options.
Siskiyou Roadhouse will be located at 1281 S. Main St. on the 1.17-acre lot where Honest John's Landscaping is currently located. The nursery remains open for business on the west side of the property, with access from Bruce Street, and access to the restaurant will be via Main Street.
According to Kennedy, construction on the 4,000 square-foot restaurant began in April and is scheduled for completion this September.
In addition to a lunch menu, the restaurant will serve homemade-style steak, prime rib, lobster, unique salads and vegetarian dishes. The bread will be baked on site.
The restaurant building will feature a full bar with a television, a fireplace, vaulted ceilings, a spacious dining area and a window in the kitchen so children can watch their steaks being cooked. The covered outdoor patio dining area will include a fireplace and water features.
"We wanted something new and fresh," commented John. "This will be a laid-back environment for people to come and kick back."
Within six months of opening, Kennedy said he and his co-owners plan to expand the restaurant, creating a banquet room for special events. At that time, between 40 and 50 parking spaces will be added to the property.
Siskiyou Roadhouse will be open seven days a week from 11 a.m.-9 p.m. on weekdays and 11 a.m.-10 p.m. on weekends. The restaurant's phone number will be 842-YUMM.
"I look forward to getting this place done and open for business," said Kennedy.


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I am wondering how do you set the parameters appropriately for $a_n,\,\alpha,\,\text{and }b_n$ to plot the family of solution of:
$u_n(r,t) = [a_n\cos(k_n\alpha t)+b_n\sin(k_n\alpha t)]J_0(k_nr)$
where the Bessel function of the first kind of zero order represents $J_0.$
$0<k_1<k_2<\ldots<k_n<\ldots$ are all positve zeros of $J_0$.
The original equation is: $u_{tt}=\alpha(u_{rr}+\tfrac{1}{r}u_r), \quad 0<r<1,~ t>0,$
$u(1,t)=0, \qquad t>0,$
$u(r,t)$ remain finite as $r\rightarrow 0^+,$
$u(r,0)=f(r), \qquad 0<r<1,$
$u_t(r,0)=g(r), \qquad 0<r<1,~~$ where $f,g$ are initial displacement and velocities.
I tried something of the type:
0<r<1; t>0; Plot3D[Cos[8.654 t] + Sin[8.654 t] BesselJ[0, 8.654 r], {r, 0, 1}, {t,0, 10}]
Choosing other parameters in the solution to have the value of 1.
The output would resemble the following:
First graphic is for $J_0(2.4r)$, Second graphic is for $J_0(5.5r)$, and Third graphic is for $J_0(8.7r)$.


text: Contact, Questions and Answers - Thesis, Prop Making Do you want to know more about the course? Frequently Asked Questions How do I apply to a programme or course? To apply, please follow the link below to University Admissions. This information is only given in Swedish. This information is only given in Swedish. Is it possible to apply for a scholarship? The Swedish Institute Study Scholarships targets highly-qualified students from many different countries. See information and links here » I have a disability. What support is available and who should I contact? Information about regulations and who to contact is available at: ltu.se/funka » How can I find an apartment? Read more about housing Can't find the answer to your question? Ask your questions in our form , opens in new tab/window or give us a call: +46 (0)920-49 20 00 [/_special-polopoly/FormArticle.htm?a=115338&l=en]


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Why not indulge in a scrumptious Afternoon Tea at Patisserie Valerie - Covent Garden. Enjoy the great British tradition at a venue that has been treating its customers to delicious patisseries since 1926.
Patisserie Valerie have been famous for their handmade pastries ever since Belgian born Madam Valerie opened their first store in Soho. Afternoon Tea is served in the main restaurant, which pays tribute to the chain's continental heritage with its traditional bistro furnishings.
Their Afternoon Tea menu features a variety of classic savouries, alongside scones and a selection of sumptuous patisseries that have given the chain its international reputation.
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Afternoon Tea is served 2pm to 5pm Sunday - Friday & 3pm - 5pm on Saturdays
Booking is essential
Covent Garden
Please wait at the 'please wait to be seated' sign inside entrance
In the restaurant
No dress code
Children of all ages welcome
No live music
All major credit cards accepted
Guide dogs only


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Braves taking their time with Pastornicky
LAKE BUENA VISTA, Fla. -- Manager Fredi Gonzalez believes that infielder Tyler Pastornicky will miss a week or more of Grapefruit League games while he rehabs for his surgically repaired right knee.
"We've got to take our time and make sure that thing is good," Gonzalez said. "He feels great when running forward."
Should Pastornicky's rehab continue into the regular season, Ramiro Pena will fill the role of utility fielder. Pena has played third base, shortstop, second base and outfield during his career. Pastornicky has played shortstop, second base and outfield since making his MLB debut in 2012.
Pastornicky tore an ACL in his left knee on Aug. 14 when he collided with Jason Heyward in right field while playing second base and underwent surgery on Aug. 19.
Pena sustained his own season-ending injury on June 9, when he landed on his right shoulder while making two diving catches against the Dodgers. He underwent surgery on June 27.


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Popular Posts
The 2018 apple season started out with not the best weather – it rained and rained and rained some more. One afternoon on a whim, my mother...
The Northern Spy is a variety we're just finally starting to get a decent crop off. Northern Spy is an heirloom apple that characteristical...
Many people have asked for the story of how our orchard came to be. In the late 60's Frank was in the Navy, and was stationed at the Bremer...
The Crimson Crisp is another new variety in our shop this year. It seems to me that the majority of the people that sample them end up buyi...
For all current information on Lapacek's Orchard please visit our new website www.LapaceksOrchard.com Thank you all so much!
Since the orchard now has ground cherries, I wanted to share this easy jam recipe. Ground cherries are delicious as a raw fruit, but they ma...
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Week 3 of Kids in the Garden and Trip to Burr Oaks Garden on Monday!
I have to be honest that I wasn't actually at the 3rd week of Kids in the Garden. I was lucky enough to get into a quilting class taught by Victoria Findlay Wolfe that day. So, I'm working off Diane's notes for this blog post…
The kids started out by the rain gauge to see that we've had 5" of rain since last week…quite a bit of change since the 2012 season.
Next – it was time to measure the sunflowers. This week 3 of the sunflowers measured in at 7", 9" and 6". The main talk of today was about edible flowers. Please remember – only eat a flower, plant or berry that you find outside if a knowledgeable adult tells you they're okay to eat. Never just eat something because it looks pretty or you're curious.
Different flower's that are edible:
- Bachelor Buttons
- Borage
- Calendula
- Carnation
- Chamomille
- chive
- daylily
- garlic
- lavender
- marigold
- mints
- nasturtium
- scabiosa
- stock
- viola
Three flowers were sampled by the children. The poll showed that 11 kids liked the pansy and 1 did not, 7 liked the bachelor buttons and 5 did not and that 8 children liked the Nasturtium and 4 did not.
Edible flowers weren't the only thing on the menu. The children also helped gather mint leaves. They got to taste chocolate milk with mint. It looks like 12 kids liked it and one did not.
Once snacking was done – any of the leafy extra's were fed to the goats.
The rest of the gardens had to be checked on as well to see how they were growing and if any work needed to be done in the gardens. I'm hoping Diane can fill in on anything exciting happened in this portion of the afternoon…
Burr Oaks Garden LLC Visit
Anyway – don't forget! THIS MONDAY, July 1st, we're taking a little field trip to the CSA Burr Oaks Gardens, LLC to find out more about how community supported agriculture works. We're all going to meet at 9:00 at:
Burr Oak Gardens
W5511 County Road B
Rio, WI 53955
please send me an email at: lapaceksorchard {at} gmail {dot} com to let me know if you're coming. If you forget to let me know and decide to come last minute that's just fine too!
Week 2 of Kids in the Garden
We had beautiful weather for our second week of Kids in the Garden! The number of kids attending wasn't super high but many were busy at 'Camp Invention' this week and we managed to have fun either way!
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We started with a quick poll about last week's snack, scrambled eggs with basil and 6 kids liked them, 2 thought they were okay and just 1 didn't like them. I would call that a success.
Next – it was time to visit the garden. We visited our sunflowers first. This week we measured 3 plants. One was 2", another 5" and a third 4". They're growing!
We had to go visit another garden so we could start collection produce for our snack. First we saw broom corn, sweet corn, brussel sprouts, cauliflower and cabbage which are all still growing and not ready for eating. We were able to pick some yummy kohlrabi's and fresh lettuce that the kids would get to try in just a bit.
Then we headed back to the garden by the goats were we checked out the onions and the different pea plants. The kids counted how many potatoes were growing in the buckets and we have 15 to 16 success stories so far. Capri was kind enough to pick a few of the radishes growing in her garden for us to try out and the kids picked a few more out of our garden.
Now it was time for our snack! we cut up the lettuce, kohlrabi and radishes for the kids to all try. We like that the kids at the very least try the snack…we never make them eat it all if they don't like it (we have goats to finish anything off) but it's great when a child discovers that they do like something they thought they didn't!
Since vegetables aren't always the tastiest just by themselves we wanted the kids to try out a few 'dip its' to add to the flavor of the veggies. We tried them with peanut butter, ranch and salt.
The results – 6 kids would have kohlrabi again, 2 would not. All 8 would have the lettuce again. 4 liked the radishes and 4 did not like the radishes (5 in the not like if you count me…but I did like the kohlrabi!) In was unanimous that the kids enjoyed all the 'dip its' on their veggies.
It was getting a little warm at this time so the kids either took a break to play or feed the goats the leaves from the veggies we picked for sampling.
Once our break was done we checked out the small strawberry patch we have…maybe samples next week…I know my fingers are crossed! Then we had to go and visit the other fruit trees on our farm that aren't apples. Plums (we might be getting 2 plums this year), peaches…also very sparse in the fruit department, cherry – we just planted one tree this year for Capri, and I'm happy to report the pear trees are just loaded!
Last stop before the day was done was to see what was happening at the pumpkin patch so far. Not much other than they're starting to sprout. it will be fun to watch the patch grow and develop over the next few weeks!
Does this sound like fun? Bring your child next week Wednesday from 2:00 – 3:30. Drop in's are welcome at just $5/kid/day.
Download the Week 2 Worksheet for your child to complete (100% optional) and bring it back next week by clicking HERE.
Thanks to everyone who came out for our second day and for being patient having me as the leader! I'm happy to say that Diane will be back next week and for the remainder of the summer to head the class.
Kids in the Garden–Week 1
Amazingly we managed to avoid rain and storms for our first week of 'Kids in the Garden'.
We saw lots of familiar faces and welcomed new ones into our group. The kids started by meeting the animals and getting a 'low down' on what was going to happen this summer. Next – they planted some beans to climb up the old play set. It seems that kids always like when they get to play in dirt.
Next – it was time to get together our 'garden treat' for the day. We sent the kids into the chicken coop to each gather an egg. It was a first for many. Next – they each picked a leaf of basil. The kids split into two groups – one for cracking and scrambling the eggs and the other for chopping up the basil. Once Diane friend up the eggs the kids got to each try a little cup of fresh from the coop scrambled eggs with a little basil and salt and pepper for seasoning.
I'm pretty sure Jason enjoyed the eggs. He politely went back for seconds…four times!
Once the treat was done we gave the kids a little break and then it was time to visit the gardens. The kids measured the sunflowers at 1" tall. It will be fun to track their growth – hopefully with some rain this year.As a little treat – all the kids that came to the first day of 'Kids in the Garden' got to take home a potted ever bearing strawberry plant that they can raise and take care of at home this summer.
We ended the day by checking out the snapping turtle that had made it's way into our front yard while we were gardening. Frank and Diane returned him to the marsh down the road on their way home from our house that night.
Does this sound like fun? Bring your child next week Wednesday from 2:00 – 3:30. Drop in's are welcome at just $5/kid/day.
Download the Week 1 Worksheet for your child to complete (100% optional) and bring it back next week by clicking HERE.
Thanks to everyone who came out for our first day! It's going to be a great summer in the garden!
Kids in the Garden starts TODAY! and Summer Hours
It's time! Kid's in the Garden is starting today – Rain or Shine!
It's not too late to sign your kids up! In fact – this season – it's never too late! You can either pay for the whole season OR you can drop in and pay just $5/kid/session.
You can read more about all the fun we have planned HERE.
The first 30 kids to join us today will get a strawberry plant to take home too! Don't let the rain keep you home – I promise we'll keep you busy!
Summer Hours
Yes – this year there will be Summer Hours at the Orchard.
We're going to be open on Wednesday's from 1:30pm to 4:30pm. If you can't make it at that time feel free to give me a call to set something up!
What will we have? Well – you can stock up on honey, maple syrup, canned goods, soy candles, and do gift shopping. No apples yet but we are growing lots of veggies and sometimes we have extra's – I'll keep you posted when/if/what we have for sale throughout the summer!
We'll see you at the orchard!


text:
Do you tweet, or do you twitter? The new edition of the AP Stylebook may help. Its says the "…verb forms are to Twitter or to Tweet." So either way is okay. Phew! Other new entries: the Middle Eastern eggplant dish baba ghanoush and texting as a verb.
Appropriately, you can follow the AP Stylebook on Twitter.


text:
Location: 6th of October , Egypt
Member Since: June 2012
Last online: August 2018
Open for read requests: Yes
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My dearest readers and visitors, I would like to tell you that my fourth and hopefully last college year has started and with it came my busy scheduel that I so love, which is why I would not be able to be "on" most of the time. Actually, I will be "on" on Thursdays and Fridays. The rest is as they say is history. However I would love it if you continue reading my stuff and leaving all the reading requests you want :) I wish I could get more feedbacks, positive or negative. I love to communicate and I like knowing what is liked and disliked about my works :) so don't be shy, and DON'T be lazy :D I don't care how short or long it may be ;) To be honest I am tired of the part when I am asked to give summery about myself or my life... so instead of jotting down the boring, flat information about me , hobbies, friends, etc.. I would like to tell all who shall view my account about why I love writing so.
I started when I had finished reading New Moon, my first English novel, followed by Web of Love for Mary Ballough (an author I never knew quite how to say her last name. I sounded retarded every time I gave it a try) I was fascinated by the way the words weaved images in my head, how it enriched my perception in the real world when I wasn't locked inside the world of a book. Since then, every thing I saw or felt -- may that be a particular scene in a movie or a group of children rombing in the street or the way a handsome guy or pretty girl walked or talked-- I almost always find myself wondering how would that be put in words, what are the words that would express that look, or gesture best. I now even know whether a movie was based on a novel or not... instinctively.
There, that is so much better than writing about ME... who wants to know about THAT anyway? Love is a word of very few letters in every language. Love is a simple word full of so many wonderful meaning. It brings joy and light. It shines with happiness and life. It sometimes comes with pain and aches in places we did not even know existed untill they got pained. It comforts in a friend's soothing touch and wipes tears with a mother's smile. It revives a weary old soul with a true love's kiss. And of course it inspires to no end. BUT to write about it, that would be a huge, gross injustice. Dear Bullies, That boy you punched in the hall today; committed suicide a few minutes ago. That girl you called a slut in class today; she's a virgin. That boy you called lame; has to work every night to support his family. That girl you pushed down the other day; is already being abused at home. You think you know them. Guess what, you don't. Copy and Paste this to your profile if you are against the mean bullying. I bet 99% of you wont. Sorry, my dearest friends and readers. I am going through some exams in college these days and, since it's Ramadan, time just gets lost in, well, time. It is strange, really. Therefore, I will dedicate some serious time to studying for a couple of days, and, insha'Allah by Monday all will return to its "rightful" course. Don't give up on me, though. Thanks for your support. kisses ;)
It confuses me and sometimes even annoys me when a certain story takes place somewhere I don't know what it is like, unless of course the authur gave quite the enthralling, hooking describtion of the place. Other than that it is just confuseing, not being able to imagine the scene of teh story, so I came up with something. Since there is only mountains, deserts, forests, rivers, seas and lakes and countries out there that may differs according to geografical positions, then it doesn't really matter where the story takes place. Therefore, I made up Isola Smeralda (Emerald Island) a fertile island for my imagination. Because I need forests and rivers and mountains, lots of rain and snow. Yes of course in Egypt we have river and mountains, but they are just not enough for me (we sure as hell don't have enough rain and no snow whatsoever) however you should look out for a novel that is set in Egypt entirely. I combine the writer's passion and real thoughts with the imaginary land that embraces this creativity, because we, authors, need to be comfortable while writing to get the reader into the events :) And people do like the lands of fantasy like Lord of the Rings, Hoguarts and the like, so I see that it is a pretty conveniet mix ;)
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Another milky morning in Central London and time to open all the windows to get some "fresh" air into the office. Lets face it: Life as a researcher in archaeology is usually not particularly exciting because the majority of our time is spent at our desks in front of a computer in more or less nice offices (Photo 1).
Photo 1 UP-NORTH project office at UCL Institute of Archaeology, London (photo: S. B. Grimm)
However, there are some of these days which make this job so much cooler and more exciting than any other job I can imagine: Sometimes these moments actually happen in front of the computers when you plot your results and they come out just the way you expected them to and you suddenly get the feeling to understand some patterns in (pre-) history. Quite awesome this deep history understanding!
Yet, many of those much cooler days are outside the office, when you go on field trips or archive visits or excavations. These can be nearby or at the other side of the planet – it's always interesting to poke your nose into another archive whether an earthen or a shelved one.
Since last September I have been working in London for the UP-NORTH project (https://www.facebook.com/upnorth.archaeology/ ) at UCL Institute of Archaeology – a good position to be curious. London is a pretty nice place for archaeology: The non-stop (re-) building of the city constantly produces new finds and the density of other institutions working in the field or closely related to our field such as the British Museum, the Society of Antiquarians, SOAS, or the Royal Holloway creates an amazing diary full of lectures, workshops, presentations, and exhibitions. However, to earn a living work also needs to be done.
The UP-NORTH project is funded by the ERC and tries to understand the resettlement of northern Europe after the Last Glacial Maximum (ca. 26,500-19,000 years ago) and the subsequent diversification of the behaviour of those human groups in the context of climate and environmental change. So our study period is the end of the Ice Age. In contrast to "classic" archaeologies that consider typo-technologies of material remains with the climatic and environmental indications from the site or from a larger surrounding, we try to directly connect archaeological remains with climatic and environmental analyses. We therefore use stable isotope analyses and aDNA on archaeological material. To put this in the larger context, the archaeological assemblages need a precise and solid chronology. We achieve this chronological position by dating the very same archaeological material. Yet, before any of this can be done, we need to know where the relevant archaeological assemblages can be found.
So my job in the last months was to poke my nose in other people's research: I filled long spread sheets with information about radiocarbon dates, sites, and assemblages and contacted people to find out more about those assemblages: their actual whereabouts, whether they would fit our purpose (Which pieces are actually preserved? What is preserved of them? How good is the preservation really? How many pieces are there of an ok preservation?), and whether we would be allowed to sample the material. Thus, I spent most of my time reading PDFs or books about great archaeology and writing e-mails. Once some of this e-mail writing was done – I also got to visit archives with one or more of my colleagues to either have a closer look at the material or to already take the samples such as in fantastic Brno.
What I learnt from all this? That an important part of modern archaeology is basically team work. Everyone in our team has a different expertise so that together we can cover quite a large number of questions and methods. Furthermore, we work closely with our local collaborators who have the necessary insights in the material and the sites to help us make the best choices for sampling. Without a team effort modern archaeology is simply not thinkable.
Last Tuesday we had one of these team days out: Three of us visited Jersey to see what the earthen archives there are currently revealing in the #IceAgeIsland project of our UCL colleagues Matt Pope & Ed Blinkhorn, British Museum's Beccy Scott, Southampton's Andy Shaw, and Manchester's Chantal Conneller – btw, again a team effort!
Most people outside archaeology think it's exciting to travel so much – mainly because they mix it up with their travels to go on vacation. Well, it is nice and I won't complain but let me tell you about my day out in wonderful Jersey – and decide afterwards whether you were willing to do this for some bones, stones, and rocks:
My day started with the alarm going off at 3.30am – I'm no early bird and getting up and awake to get going takes some time for me. So at 4.30am I could leave the house to catch my train to King's Cross where *surprise-surprise* my train to Gatwick was cancelled. Londoners will smile because many, especially those living south of London, know this problem too well. However, at 5am in the morning this forms quite a problem in London because the Underground is not going before 5.27am from King's Cross towards Victoria station where the Gatwick Express represents an alternative way to the airport. Yet, I got that tube and with some sprinting in Victoria Station and Gatwick Airport reached my flight at 7.20am to Jersey in time.
At Jersey Airport, me and my two colleagues plus a baby boy were picked up by Matt Pope, his daughter, and Chantal Conneller. After a short discussion about the plans for the day, we set off to Les Varines, a Late Upper Palaeolithic site that received quite some media cover last year when engraved schist plates were found there. Being in Matt's car, we received a first introduction to the island, its politics, peculiarities (they still have a bailiff there! and a scarily large looter community), and most of all its geology. So in Les Varines we were already quite well prepared when Ed Blinkhorn overtook to give us an introduction into the sites history and more insights in the complex geomorphological developments at the site and how these can be read from the 3D recording of the archaeological finds. We had a look at the structures that were gradually excavated (Photo 2) and then Chantal showed us some of the lithic material that had come out there – exciting for all the lithic lovers among us… so Chantal, the baby boy, and me. Organic material is very rarely preserved on Jersey. At les Varines they found a few bones last year. Some of which seem not to be burnt and, thus, of some interest for our project. Yet the preservation seems rather poor but if we can date them and possibly determine the species by ZooMS, it would help UP NORTH as well as the Ice Age Island project. Les Varines is one of the most northern and certainly the most north-western outpost of the Late Upper Palaeolithic Magdalenian expansion. The people leaving the remains at Les Varines went up north and then west, only Final Magdalenian people related to the Creswellian went further into Britain. By the time we were leaving the site, a first group of tourist was already guided over the site – making people aware of their heritage and making archaeological knowledge public is also part of the job. As the day of Archaeology also proves every year.
Photo 2 Excavation at Les Varines (Photo: S. B. Grimm)
On Jersey we next got on the road again to visit Beccy Scott in her intertidal excavations at Petit Portelet. Although quite a bit too old for our project, raised beaches and the possibility to find pockets of clayey loessic sediments from the Middle Palaeolithic in the intertidal zones is quite amazing. Tide can make the sea-level fluctuate up to 12-15m at Jersey – that is very impressive! Especially since the land mass can increase significantly during a very low tide. However, excavating in this spot on the beach therefore means constantly keeping an eye on the sea! Well, and not wearing too fancy clothes… (Photo 3)
Photo 3 Excavators at Petit Portelet (photo: S. B. Grimm)
We had some nice lunch nearby and then set off to the north of the island where some Mesolithic sites were explored in the past years. Unfortunately, none of these findspots revealed organic material thus far. Their location on the steep northern coast is quite interesting, in particular, since the project also collaborated with geophysicists to explore the sea ground off shore this northern coast and found that many parallel and intersecting valleys exist in the granite forming the island. Walking through these steep valleys during periods of lower sea-levels must have felt a bit like walking through a towering, stone-made Manhattan. On these spots on top of the modern coast an overview over this labyrinth of canyons was possible (Photo 4). What we could see from this spot were also many cracks and caves in the steep coastal cliffs. These are not easy to be explored as we should also find out on our next stop: La Cotte. Likewise Petit Portelet, this famous Middle Palaeolithic site can only be reached during low tide – and then you have to climb over a more or less slippery boulder field. In the 19th century, people reached this site – as well as some of the north coast caves from above via ropes that they also needed to climb back up if they wanted to leave the spots in time before the tides came back up. I clearly preferred the boulder field. And it was quite a WOW-effect turning around the cliff corner over the boulder field and suddenly standing in front of gigantic granite towers that embraced the site (Photos 5a and 5b). I doubt that coming from above has quite the same effect. This site now has a really good organic preservation – alas, the sediment our project would be interested in was shovelled away in the late 19th / early 20th century. The Middle Palaeolithic is meanwhile comparably under threat – this time it's the natural elements disintegrating the rock and the sediments and gradually letting them crumbling down and washed out to the sea. Archaeological field work is forbidden due to the potential dangers of falling rocks hitting excavators and protective measures are installed and constantly tried to be improved.
Photo 4 View from the North Coast at Les Marionneaux (photo: S. B. Grimm)
Photo 5 a (above) Marvel about the size of b (below) the La Cotte site (photos: S. B. Grimm)
We made our way back over the boulder field and beach just to see off Andy Shaw who was guiding a group of archaeology interested inhabitants to those outstanding towering granite columns of La Cotte. We got on our way back to the airport just in time to go through the security, have a little snack, and catch the plane back to London.
Mind you, I guess it is needless to say that after all this boulder climbing, heath and beach walking, site visiting, landscape learning, archaeology and geology talking I was quite shattered when I arrived back home at 10.15pm that night (this time without any serious trouble by tube or train). However, it was a gorgeous day out but I hope this little narrative will stop non-archaeologists from idealising out travels – even if they are little friendly visits as this one with lots of other chittery-chatter, they are work, not vacations! And thus on the next day we were also back in the offices… Yet with lasting impressions of a beautiful island, marvellous archaeology, and a big gratitude to our colleagues who took their time to show us around.
However, my days in the UP-NORTH project and in London are counted. In two weeks, I will have left the UK and by September I start a new position in northern Germany – so this time, I'm going up north and then east (more Hamburgian style for my fellow Lateglacial specialists). Yet, this leaves someone of you with the possibility to apply for my position (http://www.jobs.ac.uk/job/AOE765/research-associate/ ) and describe a day like mine -still different!- in the UP-NORTH project at next year's Day of Archaeology!


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Michael is in New York City for the week meeting up with book publishers, OpenSky, and judging Iron Chef. He asked me to repost Carol Blymire's Q & A on celiac disease. Look forward to a new post from Michael on Monday. And I am hoping for some off-the-cuff photos for this Friday's post from him. —Emilia
Originally posted October 19, 2010
The blog world knows Carol Blymire for her cooking her way through The French Laundry Cookbook (which is how I became acquainted with her). She's now documenting her adventures in avant-garde home cooking in her new blog, Alinea at Home. By day, she's a communications and public policy consultant in D.C. Day and night, she lives with celiac, a disease that prevents her body from digesting gluten, diagnosed after years of tests for ALS and MS and the like when her dermatologist noticed some rashes and said she probably had celiac. Sources say that 3 million Americans suffer from celiac. One in 4 is genetically predisposed to the disease. No one knows what engages the gear that activates it. Millions are likely undiagnosed. Until Carol went on a rant about what she goes through (I was likely being insensitive), I had no idea what . . . well, more people, chefs especially, ought to know.
Carol, let's make sure everyone's clear on this. Having celiac disease, the inability to digest gluten, isn't like being lactose intolerant. Or is it? I mean, really, how serious is it?
Oh jeez . . . I hope you weren't hoping to win a Pulitzer for this, because I'm going to have to talk pretty explicitly about "digestive issues." Can we do that on a food blog?
I take that to mean there's some rectal enthusiasm involved here?
Here's what happens when I'm accidentally "glutened": uncontrollable, painful, explosive diarrhea that comes on quickly with next-to-no warning within 30 minutes of ingesting gluten. So, if I'm glutened in a restaurant, it might hit while I'm still sitting there finishing up my lunch. If I'm lucky enough to make it to the bathroom on time, then I have to hope there's enough time in between "episodes" to drive home, where this lovely symptom will continue for another 24–36 hours.
Is that it?
Not even close. Over the next 48 to 72 hours, we celiacs also get to experience joint pain, stomach cramps, migraines, dehydration, numbness and tingling in the extremities, insomnia (despite being exhausted from all the butt explosions), and toward the end of it, a foggy-headed serotonin crash where it's difficult to get out of bed, think clearly, or accomplish even the most basic life skills. Oh, and bumpy skin rashes. Let's not forget those. So pretty.
Sounds like the hangover I had after my friend Blake left last weekend, something I hope not to repeat.
Getting glutened is really debilitating. If I have a big event, vacation, or important meeting, I have to plan to not eat food other than my own cooking the three days before because I can't risk being stuck at home, sick from gluten, and miss out whatever it was I needed or wanted to do. And, whenever I eat out (whether at a restaurant or a friend's house), I make sure I know all the possible places I could stop on the way home in case I get sick.
Why can't you eat at restaurants and just tell them that you've got celiac and can't eat gluten?
Cross-contamination is probably the biggest risk: you can't plate someone's spaghetti à la nero and then plate my food without washing your hands in between. You can't put a burger on a bun, re-check the ticket and see that I'm no-gluten, and just take the burger off the bun and serve it to me. I can't eat fries that have been cooked in the same oil as anything battered. If an expediter wipes the rim of a plate with bread on it before serving it, then uses the same towel edge to wipe my plate, then they've essentially just wiped my plate with a piece of bread, and I'll be sick.
So many people lie about having food allergies ("I'm allergic to dairy, so no butter" but they order ice cream for dessert) that some chefs have confessed to me that they don't take gluten directives seriously. I get it: I used to make fun of people who said they were allergic to wheat because I thought they were being dramatic and annoying.
What can chefs do to improve?
Trust that when someone says "no gluten," they have celiac and are not just trying the latest fad diet. Learn about gluten because it's everywhere. And, be extra-careful about cross-contamination—that's the biggest risk, actually, in restaurant kitchens. You can't touch bread or something with gluten in it and then touch our food without washing your hands in between. You can't just do a "whoopsie" and take the burger off the bun and serve it to us.
Having celiac can be really isolating, because it's safest and healthiest to just cook for yourself. But, I'm a social creature and I love restaurants, so I had to (and still have to) muster the courage to leave the confines of my kitchen and let others cook for me.
What should I do if I'm having someone for dinner who has celiac?
Be patient when the person with celiac asks you about every single ingredient and its origin. Be willing to read the labels of every single thing you put into a dish. Know that we understand how stressful and frustrating it can be to cook for someone with celiac; believe me, we get it, and we love you for making the effort to cook for us.
All of this comes with the gentle reminder to fellow celiacs that it's in our best interests to call a restaurant a day or two ahead to let them know we can't eat gluten. It's kind of dickish to just show up somewhere and expect a restaurant to deal with a major dietary restriction. And, always send a thank-you note or personally thank the manager and chef. It's not always easy to accommodate people with celiac, so a little thanks goes a long way.
One last question: What's been your experience when you do find a restaurant that truly understands your condition?
More than once, I've actually cried during a meal because it was so good and wasn't making me sick. A pastry chef here in town sent out a round of all his desserts that he'd made gluten-free. There are a lot of chefs who have gone above and beyond to make sure I've been safe—and that there's nothing in the world that has made me feel more cared for . . . really and truly.
I asked for a recipe to accompany this post, and Carol asked if she could post Shauna and Daniel Ahern's pizza dough for their new (excellent) book, Gluten-Free Girl and the Chef (it also makes a great cracker or flatbread dough):
Gluten-Free Pizza Dough
Carol loves this recipe because it is not only pizza dough but also doubles as a cracker dough. She topped this one with olive oil, fresh mozzarella, some Woodlands pork ham, and wine-steeped figs. She did another last night for the neighbors with tomato sauce, fresh mozzarella, ricotta, and purple basil.
Makes two 10-inch crusts if you like them thick, 12-inch if you like them thin.
- 125 grams (1 cup) cornstarch
- 125 grams (¾ cup plus 2 tablespoons) corn flour
- 125 grams (¾ cup) potato starch
- 125 grams (¾ cup) sweet rice flour
- 1 tablespoon xanthan gum
- 1 teaspoon guar gum
- 1½ teaspoons kosher salt
- 375 grams (1¾ cup) warm water, about 110°F/43°C.
- 50 grams (¼ cup) extra-virgin olive oil, plus extra for brushing
- 15 grams (4 teaspoons) active dry yeast
- gluten-free cornmeal for sprinkling on pan (not all are gluten-free due to manufacturing practices)
- Combining the dry ingredients: Sift cornstarch, corn flour, potato starch, and sweet rice flour into large bowl. Add xanthan gum, guar gum, and salt. Sift mixture into bowl of stand mixer.
- Activating the yeast: Combine warm water, olive oil, and yeast in small bowl. Stir gently. Let rest for a minute.
- Making the dough: Pour yeasty water into dry ingredients. Mix at medium speed (using the dough hook attachment) for 2 minutes, until dough comes together and feels soft and pliable. Set dough aside in a warm place and let rise for 1 hour.
- Preparing to bake: Preheat the oven to 550°F/288°C (or as hot as your oven will go). If you have a pizza stone, put it in the oven now. Sprinkle a pizza tray or baking sheet with cornmeal.
- Rolling out the dough: Cut the dough ball in half. Put one of the balls of dough between 2 pieces of parchment paper. Through the paper, roll out the dough as thin as you can make it.
- Prebaking the crust: Carefully transfer dough onto the pizza pan. Brush dough with olive oil. Bake until the dough feels firm and when you lift it off the pan, it will hold its shape, about 7 minutes.
- Take the crust out of the oven and top it as you wish.
- You can make the second crust immediately (and really, you probably will). Or, you can put it in the refrigerator and have pizza again the next day.
A few other gluten-free sites, besides Shauna's:
Gluten Free Easily, by Shirley Braden
Wasabimon, by Stephanie Stiavetti
And by a teenager, Lauren McMillan, diagnosed with celiac, Celiac Teen.
If you liked this post on What I Didn't Know About Celiac, check out these other links:
- My post and rant on Food Fascism.
- Stephanie Stiavetti's guest post and recipe for gluten-free fried chicken.
- Will heritage grain help out those with gluten intolerance?
- Lime chiffon pie recipe shared by Lauren McMillan, the Celiac Teen.
© 2012 Michael Ruhlman. Photo © 2012 Donna Turner Ruhlman. All rights reserved.


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THE ROLE OF ENDOPLASMIC RETICULUM PROTEIN GRP78 IN NORMAL HEMATOPOIESIS AND PTEN-NULL LEUKEMOGENESIS by Shiuan Wey A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (GENETIC, MOLECULAR, AND CELLULAR BIOLOGY) August 2011 Copyright 2011 Shiuan Wey
Object Description
|The role of endoplasmic reticulum protein GRP78 in normal hematopoeises and PTEN-null leukemogenesis
|Wey, Shiuan
|Author email
|Doctor of Philosophy
|Document type
|Degree program
|Genetic, Molecular and Cellular Biology
|Keck School of Medicine
|Date defended/completed
|Date submitted
|Date approved
|Restricted until
|Date published
|Advisor (committee chair)
|Lee, Amy S.
|Advisor (committee member)
Kahn, Michael
Shibata, Darryl K.
|The endoplasmic reticulum (ER) is an intracellular organelle for protein folding, lipid synthesis and Ca²⁺ storage. It is also responsible for the transportation for most of the secretory and transmembrane proteins. When the protein load exceeds the ER folding capacity, the ER undergoes stress and activates a set of signaling cascades that is termed the unfolded protein response (UPR). The multifunctional GRP78 is the major ER molecular chaperone with protein folding abilities and the master regulator of the UPR, and recently has been shown that a subfraction of it is localized on the cell surface acting as a co-receptor for various signaling pathway activation. ❧ Traditionally GRP78 is regarded as protective against hypoxia and nutrient starvation prevalent in the microenvironment of solid tumors, thus, its role in the development of hematologic malignancies remains to be determined. In this thesis, elevated GRP78 expression was detected in leukemic blasts of adult patients, leukemia cell lines and inversely correlates with time to relapse in childhood acute lymphocytic leukemia. To directly elucidate the requirement of GRP78 in leukemogenesis, we created a biallelic conditional knockout mouse model of GRP78 and PTEN in the hematopoietic system. Strikingly, heterozygous knockdown of GRP78 in PTEN null mice is sufficient to restore the hematopoietic stem cell (HSC) population back to the normal percentage and suppress leukemic blast cell expansion. AKT/mTOR activation in PTEN null bone marrow cells is potently inhibited by Grp78 heterozygosity, corresponding with suppression of the PI3K/AKT pathway by GRP78 knockdown in leukemia cell lines. This is the first demonstration that GRP78 is a critical effector of leukemia progression, at least in part through control of oncogenic AKT signaling. Furthermore, overexpression of GRP78 renders human leukemic cells more resistant to AraC-induced apoptosis whereas knockdown of GRP78 sensitizes them, suggesting GRP78 is a novel potent therapeutic target for leukemia. ❧ Hematopoietic stem cell (HSC) homeostasis in the adult bone marrow (BM) is regulated by both intrinsic gene expression and interactions with extrinsic factors in the microenvironment. GRP78 has been shown to be critical for the maintenance of cellular homeostasis and prevention of apoptosis. Homozygous knockout mice of GRP78 are embryonic lethal at E3.5, indicating GRP78 is essential for embryonic cell growth and pluripotent cell survival. However, this has not been investigated in adult hematopoietic stem cells. Here we generated a conditional knockout mouse model that acutely deletes GRP78 in the hematopoietic system. GRP78 deficiency results in a significant reduction of HSCs, progenitor and lymphoid cell populations yet an increase in myeloid lineage granulocytes and monocytes in cKO mice. The GRP78-null induced reduction of the HSC pool can be attributed to enhanced apoptosis. In agreement, GRP78 deficient BM cells exhibited activated UPR signaling in all three branches and induced expression of pro-apoptotic CHOP and caspase activation. Transplanting Grp78 KO hematopoietic cells into WT microenvironment also yielded a decrease in HSCs, suggesting that GRP78 in hematopoietic cells is required for HSC survival and homeostasis. In addition, a multiplex cytokine assay reveals alteration in several cytokine serum levels in cKO mice, suggesting GRP78 plays a pleiotropic role and is essential in regulating hematopoietic system homeostasis and maintenance.
|GRP78; AKT; PTEN; leukemia; hematopoiesis
|Part of collection
|University of Southern California dissertations and theses
|Publisher (of the original version)
|University of Southern California
|Place of publication (of the original version)
|Los Angeles, California
|Publisher (of the digital version)
|University of Southern California. Libraries
|Electronically uploaded by the author
|Legacy record ID
|Contributing entity
|University of Southern California
|Wey, Shiuan
|Physical access
|The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given.
|Repository name
|University of Southern California Digital Library
|Repository address
|USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA
|Repository email
|Archival file
|Page 1
|Contributing entity
|University of Southern California
|Repository email
|Full text
|THE ROLE OF ENDOPLASMIC RETICULUM PROTEIN GRP78 IN NORMAL HEMATOPOIESIS AND PTEN-NULL LEUKEMOGENESIS by Shiuan Wey A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (GENETIC, MOLECULAR, AND CELLULAR BIOLOGY) August 2011 Copyright 2011 Shiuan Wey


text: Aluminium disk dog tag Aluminium disk dog tag Aluminium disk dog tag Aluminium disk dog tag €14.99 Quantity: at €14.99 each Add To Basket Hand stamped Aluminium disk dog tag We've all been there: you've just adopted your new pooch and you're hitting up your local pet store to pick up supplies. Right away, you know you'll need food, treats, a bed, a bowl, a leash, a collar (dang, this dog is expensive!) and… what are we forgetting?… oh, duh, a dog tag! While many pups are microchipped these days, having a good ol' fashioned dog ID tag hanging from their collar is still a great idea. And so we can't blame you if, like most of us, you use one of those handy machines to print your new friend's name and your number on one of those shiny blue or gold bones or hearts. It's easy, it's cheap and it works. But we know how obsessed with your dog you are, and how over-the-top you often go to pamper and accessorize them in the coolest, most fun ways. So we're betting plenty of you have graduated from those initial purchases to flashy new harnesses, collars, and maybe even more unique dog tags. There's tons of fun finds once you start digging, so if you're thinking it's about time to gift your pup with a shiny new ID tag, you've come to the right place. We hand stamp your details into the metal tags and unlike surface engraved tags these will last for a very long time maybe forever, tags are no use if you cant read them, : )


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Both the San Jose Sharks and Tampa Bay Lightning attempt to take two-game leads in their respective playoff series. For the Sharks, that'd mean holding rink against the Detroit Red Wings. For the Lightning, that'd mean heading south only needing to win two of three home games against the Washington Capitals to advance to the conference finals.
Detroit/San Jose's on at 3 p.m. eastern. Tampa/Washington follows at 7 p.m.
Noon start may be better for Red Wings than Sharks [San Francisco Chronicle]
Red Wings' Johan Franzen is moving closer to playoff form [Free Press]
Capitals were undone by their poor power play [Washington Post]
Injured Simon Gagne, Pavel Kubina not expected to play for Tampa Bay Lightning in Game 2 of East semifinal vs. Washington Capitals [St. Petersburg Times]
(Photo H/T Don Smith/NHLI)


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I don't think this is really a valid point against Dakota. What person can you name that is literally innocent on the outside and evil on the inside (as you put it)? Not to mention the fact that this person also needs to be an actress and the right age to play Jane. Yes Dakota is innocent inside and out (thank God... she's only 15!), but since she is an established actress I don't think she'll have a hard time portraying the "evil" part. After all, that's what acting is all about - playing a part, not actually BEING that character in your everyday life.I.WANT.TO.BE.BELLA wrote:6: She is not pretty enough to play a vampire who is innocent on the outside and evil on the inside. Dakota is just innocent on inside and out so how can she portray Jane?
I'm curious, do you also have this same problem when watching movies with any well-established actor/actress? Like are you ever just sitting there watching Saving Private Ryan but then suddenly get all confused and think you're watching Forrest Gump because they both star Tom Hanks? That's just weird to me. And I'm being sarcastic here, as I'm sure you were when you first wrote that comment. Do you see how ridiculous it sounds?I.WANT.TO.BE.BELLA wrote:7: She is in SOOOOOO many movies i will get mixed up when i see her and wonder what movie i am watching.
Like many actors before her, Dakota is taking on a new role that she's never done before. I think confusion on which movie you're watching should be at a minimum. Plus, the presence of vampires and werewolves should help clarify things so you don't mistake New Moon for like I Am Sam or something.
I'm not trying to be harsh here, I just think people are being way too critical about this. It's like the uproar that happened when Rob was cast as Edward and now people absolutely love him, for the most part. Give the girl more credit, she deserves the benefit of the doubt. I don't think Dakota's previous success should be held against her. And I think she'll be great as Jane.


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text: TRAFFIC ADVISORY: Access to and from RFK Stadium from I-395 via the Southeast/Southwest Freeway has been rerouted due to the District Department of Transportation's 11th Street Bridge Project. For current traffic routes to and from RFK Stadium via I-395, please click here. Access from DC-295 and other points are unaffected.


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It seems JSBuilder fails on a valid regular expression. I am trying to compress the Dav Glass YUI Addon Tools.js and I get an unterminated string literal error from JSMin on the following line:
(notice the odd number of double quotes)Code:syntaxCheck: /^("(\\.|[^"\\\n\r])*?"|[,:{}\[\]0-9.\-+Eaeflnr-u \n\r\t])+?$/
BTW, Jack thank you so much for yui-ext and the JS Builder tool -- they have been a huge help for me.


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NASHVILLE -- On the eve of this year's Winter Meetings, Orioles executive vice president of baseball operations Dan Duquette re-emphasized that the team's top priority is acquiring a middle-of-the-order power bat.
Speaking to reporters Sunday night at the Gaylord Opryland Resort and Convention Center, Duquette said the Orioles are more likely to address that need via trade, but they will continue to monitor the free agent market.
"I believe we will be able to do some good here," Duquette said. "We're working all the time, the timing of these deals isn't always at the winter meetings, but it's a good time to close on a deal, so we are going to do what we can to help our team this week."
The non-tendering of first baseman Mark Reynolds, which occured Friday, made the Orioles' need for a power bat a more pressing one, Duquette said. He added it didn't matter whether it was a left-handed of right-handed hitter.
Duquette said that since the organization has acquired a "surplus" of pitching, the Orioles could be willing to part with pitching in order to get that power hitter.
"We have more depth through our pitching staff, which is a good thing, right?" Duquette said. "And we have a number of young pitchers on the horizon, in [Kevin] Gausman and [Dylan] Bundy, that could come up during the year and help us. We also have more qualified major league starting pitchers than we have slots. But all those things are good things. So if we have a surplus as perceived by other teams then we could make a trade that could help us in another area."
Duquette added he's comfortable with his options at second base -- the team claimed Alexi Casilla off waivers -- and feels the team has added organizational speed and defense with the addition of Casilla, outfielder Trayvon Robinson and Yamaico Navarro.
The Orioles also look to be active in Thursday's Rule 5 draft, coming off the success of last year's draft, when they took infielder Ryan Flaherty from the Cubs and were able to retain him all season. The Orioles have the 23rd pick in this year's Rule 5 draft.
Also of note:
-- Duquette said while the team still has interest in resigning outfielder Nate McLouth and pitcher Joe Saunders, the Orioles haven't had any contact with Jim Thome.
-- Orioles manager Buck Showalter said he had narrowed his third-base coach search and would like to name name his selection by the end of the meetings.


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Hello Hostesses!
If you're anything like me, you've been bustling around this week, making lists of…well, darn near everything. Groceries, to-dos, important events… and of, course, with one of the most festive holidays fast approaching, you may also be making lists of people you'd like to include in your celebrations, and what you plan to give them.
I've received mishloach manot on Purim that were supremely elaborate and packed to the brim, and I've also received bags of goodies that were extremely thought provoking and personal. One in particular that comes to mind was a bag given to me by one of the ushers at my temple, a lady whose friendship I am lucky to have. Her gift certainly showed how much thought she'd put into it, maybe in a little less conventional way. Her pointedly plain, brown paper bag included one small bottle of kosher wine, one apple, one bag of carrot sticks, one bag of prune hamentashen, and one bag of ribbon candy. Included was a note about how each item in the bag requires a different blessing, and that in the midst of all the revelry, we should take the time to remember the holiness in each item. It was a very touching sentiment, one that I will remember fondly for years to come.
There are many ways to put together your gifts of Purim food items. A popular way to arrange your baskets is to create themes, based on whatever strikes your fancy–the season, the recipient's hobbies or passions, a sports or movie theme, a springtime theme if it's warm where you are, or a chilly weather theme if you're still getting snow. It can be kosher foods based on a favorite movie or play, a color theme, anything your heart desires.
I made a few different theme baskets to show you this year.
This happy hostess is stuck in Saint Louis, where we got another inch of ice and snow last night. While hunkered under my blanket with my husband, I thought about some of my warm and cozy comfort foods. And thus, the Snuggle Purim Basket was born:
This basket was super easy to put together. I bought:
- Some 1-quart canning jars
- A bag of raffia
- A rectangular basket, about 4″ deep
- A small 1-cup jar with an airtight lid
- Pre-made ciabatta rolls from a local bakery
- A tin of chocolate chip cookies
I made a large batch of basic vegetable noodle soup. You can also simply buy cans of your favorite ready-to-eat brand. Because the cookies and ciabatta contain dairy, I'd stick with vegetarian soups like vegetable barley, tomato, split pea, etc.
I ladled the soup into the clean canning jar, place the lid tightly, and wrapped with raffia to make a decorative bow. Because this should be eaten quickly, there's no need to actually "can" and pressurize the soup unless you think the recipient will want to store it. It will keep, refrigerated, for 2-4 days. For artistic purposes, I removed the packaging from the ciabatta and cookies, but you can keep yours on if your baskets will be sitting out a while.
I spooned about a cup of cappuccino mix into my smaller jar. You can use instant coffee, hot cocoa blend, teabags, whatever you like. You can add a note if you like, by writing out mixing instructions on a small tag and tying it to the jar with a strand of raffia or ribbon.
Ray of Sunshine Purim Basket:
To battle some of this cold, I thought–"What's the most bright, summery activity there is?" The answer was immediate–picnics, of course! What says summer cheer better than red and white checked tablecloths, fresh fruit, and sunshine? Nothing I can think of.
So I put together the "Ray of Sunshine" basket.
This is arranged in an actual picnic basket, and though the photos are too close to see, all the food items are nestled in red and white checked cloth napkins. A trip to Hobby Lobby allowed me to pick up some silk sunflowers and some fuzzy little bees for decoration. They attach with wire, easy peasy.
In this basket, I arranged all your summer picnic staples.
- Cold fried chicken– picked up at a local deli.
- Fresh fruit
- A large bottle of lemonade A canning jar filled with Fresh Garden Salad, decorated in a gingham ribbon.
- Corn on the cob, wrapped in aluminum foil
- Chocolate chip cookies– if your recipient keeps kosher, substitute a non-dairy dessert, such as macaroons or pareve hamentashen.
Even though summer is quite a ways away here in St. Louis, one can always daydream about it. One of my favorite things to do when the weather is warm is visit one of our many beautiful vineyards. My husband and I used to make a monthly tradition of visiting a local winery and enjoying an afternoon on the terrace. So when I asked him for a basket idea, he suggested perhaps revisiting one of our favorite themes.
The "Afternoon at the Vineyard" Purim basket:
This is a smaller basket, but absolutely packed with decadence and deliciousness.
Everything is snuggled nicely into a green satin cloth napkin. You can use raffia or cotton batting underneath to help keep everything in place and fill in any extra spaces–not that you'll have extra room with all the goodness in here!
This basket contains:
- Two single-serving bottles of sweet Riesling. Any bottle of your favorite wine will work. Or you can give juice.
- Bunches of grapes, both green and red
- A wheel of Gouda (again, any cheese will be fine–just make sure it's a hard enough cheese that it can withstand room temperatures if it will be sitting out for a while. You can find kosher cheese at any local Whole Foods or kosher market)
- A small tub of hummus. I chose sundried tomato and basil flavor.
- A package of water crackers. I chose "vegetable medley" flavor.
I stuck a few cookies in there to fill out the space, and I also had a small tub of olives–greek and italian, packed in oil, but they somehow got swiped. I think my husband forgot I was making baskets and helped himself to a snack.
Purim Brunch Basket:
And of course, if you or your little ones will be delivering baskets in the earlier hours, nothing beats a Purim Brunch Basket! Give your recipient the best gift of all–a full gourmet breakfast with no dishes and no cooking!
I picked up a few things for this basket, but it's all super easy stuff to make yourself, too.
I used a basket I had around the house, and just lined it in a remnant of pretty pastel polkadot fabric I bought at a craft store. With prices usually less than $5 a yard, check out your local fabric or craft store's clearance racks for interesting fabrics. You don't have to buy a lot, and it always comes in handy for lining gift baskets, wrapping jars, anything!
This one is so versatile. You really can put anything in it.
I chose to add a 2-serving spinach and mushroom quiche. You can make your own, or make a dozen little mini-quiches, instead.
I also bought a couple miniature loaves of pumpkin raisin bread from my favorite Mom-n-Pop bakery, and accompanied these with fresh fruit and two bottles of Simply Pure orange juice.
You can mix and match whatever you like into such a basket:
- Dry cereal and bottles of milk
- Homemade bread, scones, or muffins
- Hard boiled eggs, in the shell
- A wheel of cheese
- Pastries
- Homemade granola bars
- Jars of instant coffee or teabags
Oh, my head is reeling from all the choices!
Whether you copy one of these, or if one item inspires you and you run with that idea into a whole new world of possibilities, your recipient is going to adore your gift and the thought that accompanies it. It doesn't have to be fancy or elaborate. Even if your goodies are simple and tucked into a plain paper bag, if you put a little thought and meaning into it, the person who opens it is sure to remember it for years to come.
Enjoy, and happy eating!
Charlie Michelle
Related articles
- Sweet and Savory Hamentashen by Leah Koenig (thejewishhostess.com)
- How to Add Drama and Fun to Your Purim Seuda Table (thejewishhostess.com)
- How to Make Chocolate Dipped Pretzels For Purim (thejewishhostess.com)
- Purim Table Decor That's Fit For a King (thejewishhostess.com)
- Queen Esther Reigns and Entertains With Regal Purim Decor! (thejewishhostess.com)
- Purim Table Decor That's Fit For a King (thejewishhostess.com)
- Get Your Popcorn Toffee Drizzled Mishloach Manot from The Jewish Hostess (thejewishhostess.com)
- Wishing You A Purim Table Setting with Power and Panache! (thejewishhostess.com)
- Egg, Nut, and Dairy Free (Vegan) Hammentashen for Purim (thejewishhostess.com)
- The Jewish Hostess Post Purim 2011 Party ReCap (thejewishhostess.com)


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Lions, tigers, and Crown Royal? Well, why not. The noted Canadian whisky recently recruited the king of the jungle for its newest television commercial which is bound to catch the attention of many. It looks like "Reign On" might serve as a sneak peek at Crown Royal's newest campaign and what better way to flaunt your reign than with a lion. Oh, and Bobby Bland's "Ain't No Love In The Heart Of The City" of course. That song is commercial gold. Also, it should be noted that the YouTube description for the commercial reads, "A roar sounds even mightier over clinking glasses." I like it…I like it a lot.
You'll Also Like: Drink Recipes: Warm Up To The Season With Cocktails From Crown Royal Maple Whisky


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27.0202 Definitions.
As used in this chapter, unless the context clearly requires a different meaning the following definitions apply:
(a) "Business" means and includes any activity or conduct (whether proprietary, partnership, corporate, or whatever form) engaged in, or caused to be engaged in, with the object of gain or economic benefit, either direct or indirect, but does not include casual sales or personal service contracts.
(b) "Commission" means the Territorial Planning Commission of American Samoa.
(c) "Endorsement" means and includes written evidence obtained by an applicant from the examining department that the applicant has fulfilled the necessary qualifications and requirements prior to the obtaining of the license. It also, when the context so requires, means and includes the evidence of endorsement appearing on the face of the license.
(d) "Engaging in or carrying on a business" means a regular employment which occupies the time, labor, or attention of the person on a continuing basis although one act may be sufficient if circumstances show a purpose to continue, and it need not be the sole or full-time employment of the person, but may be on a part-time or periodic basis.
(e) "Examining agency" means that agency of the government or department of the government which is by law, rule, or regulation given the responsibility of examining and endorsing a class of applicants for required qualifications.
(f) "License" means and includes the permission granted by the Territory of American Samoa under authority of this chapter conferring upon the licensee the right to engage in a business or practice a trade or profession which without the authorization and permission would be illegal; it also, when the context so requires, means and includes the written evidence of that permission.
(g) "License fee" means the charge or assessment levied by the law for the privilege or authority to do that which, without payment for and obtaining the privilege or authority, would be illegal under the provisions of this chapter.
(h) "Person" means and includes any individual, over 21 years of age, firm, copartnership joint venture, association, corporation, estate, trust, or other combination or group acting as a unit.
(i) "Renewal" means the continuation for the next succeeding year of the privilege to conduct the licensed business except that no license shall be renewed unless the application is made therefor within 3 months of the expiration of the last license issued.
(j) "Treasurer" means the Treasurer of American Samoa or his designated representative.History: 1975, PL 14-4 § 2; amd 1978, PL 15-92 § 1.
Amendment: 1978 Paragraph (b): substituted "territorial planning" for "economic development".
Case Notes:
Absent a requirement that all persons engaging in business have a license, only those businesses which are without a license would otherwise be illegal, either malum in se or malum prohibitum, need a license. Government v. South Pacific Island Airways, ASR (1976).


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IRAs for the Unemployed
If you or your spouse has earned income for the year, you can fund an IRA.
Do I need to have a job in order to contribute to an IRA?
Not necessarily. You usually need to have earned income from a job sometime during the year to contribute to an IRA for yourself. (Unearned income from pensions, investments or Social Security doesn't qualify.) However, if you're married and don't work but your spouse does, then he or she can contribute to a spousal IRA for you. So stay-at-home parents, retirees with a spouse who is still working, and others who were unemployed for the year but had a spouse who earned an income have a chance to boost tax-advantaged retirement savings.
The working spouse can contribute up to $5,000 to his or her own IRA and up to $5,000 for the nonworking spouse for 2012, as long as the working spouse's annual income was at least as much as the combined contributions. You can add an extra $1,000 for each spouse who is age 50 or older. You still have until April 15, 2013, to contribute to an IRA for 2012. For 2013, the contribution limit has increased to $5,500 per person, with the catch-up contributions remaining at $1,000 for people age 50 or older.
The spousal IRA can be either a Roth or a traditional IRA. To qualify for a Roth for 2012, the adjusted gross income on your joint tax return must be less than $183,000 (the amount you can contribute starts to phase out above $173,000). Single filers can contribute to a Roth as long as their income was less than $125,000 (the amount you can contribute starts to phase out above $110,000). The income limits are slightly higher for 2013 contributions –- see my column for details. You can access Roth contributions anytime without taxes or penalties, and you can withdraw earnings tax-free and penalty-free after age 59½ as long as you've had a Roth for at least five years.
There are no income limits for contributing to a traditional IRA, but your income must be below certain limits for your contributions to be tax-deductible. Withdrawals (except for any non-deductible contributions) will be taxable. See Fund an IRA, Cut Your Taxes for details.
Keep in mind that kids who have any income from a job can make IRA contributions, too -- even if they just earned a little money from babysitting, mowing lawns or any other part-time job -- as long as their contributions are not more than the amount of money they earned for the year. See Open Low-Minimum Roth IRAs for Kids for details.
For more financial-planning advice, log into our Jump-Start Your Retirement Plan Days on February 7 and February 12. You can get a free one-on-one session with a member of the National Association of Personal Financial Advisors (NAPFA). We'll be featuring four chat rooms hosted by financial advisers, focusing on taxes and retirement, saving for retirement, income in retirement, and other financial challenges. See Jump-Start Your Retirement Plan Days 2013 for more information and to sign up for the live chats.


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Renting your home when you aren't there can seem like a great way to generate additional income, yet it can also generate risks that some typical home insurance policies might not necessarily cover.
That's why both our household and holiday home policies are developed to cover Airbnb hosts too, giving you the flexibility to rent out your home to guests as and when you want.
Airbnb is changing the tourism industry and creating new opportunities for tourists, business travellers and hosts. As an Airbnb host, if you're insured with Intasure, you will automatically be covered for the below:
Cover for loss of rent means that if, for example, your house incurs damage such as a burst pipe – preventing either yourself or a guest from staying – you won't miss out on the income you would have made from your Airbnb guests.
Plus we understand the last minute nature of Airbnb bookings, so you don't need to contact us every time you receive an entire property booking; you just have to let us know if you have received a partial room booking.
To find out more get in touch with Intasure today!Get a Quote Now
This provides you with a summary of the AirBnb Host insurance cover. For precise details of cover, including the conditions and exclusions that apply, the policy document itself should be referred to.
Product information
AirBnB insurance, View and download Insurance product information document - Click here
Policy Wording
UK Holiday home insurance, View and download policy wording - Click here
Legal Assistance
View and download policy
Keyfacts - Click here
Wording - Click here
Intasure ® is a trading name of Arthur J. Gallagher Insurance Brokers Limited, which is authorised and regulated by the Financial Conduct Authority. Registered Office: Spectrum Building, 7th Floor, 55 Blythswood Street, Glasgow, G2 7AT. Registered in Scotland. Company Number: SC108909 | UK Privacy Notice | Legal & Regulatory Information | Cookies