text:
Aug. 26 is Women's Equality Day, which this year celebrates the 94th anniversary of the 19th Amendment giving women the right to vote.
American women won this right in 1920 after a decades-long struggle that began in 1848 when Elizabeth Cady Stanton and Lucretia Mott organized the first women's rights convention in our country's history.
More than 300 women and men came to Seneca Falls, N.Y., to protest the mistreatment of women in social, economic, political and religious life. In the following decades, thousands of people participated in marches through cities like New York and Washington, D.C., wrote editorials and pamphlets, gave speeches all over the nation, lobbied political organizations, held demonstrations, picketed the White House, went on hunger strikes and spent time in jail for their activism. Our foremothers realized they had a critical role to play in the political, social and economic life of their society and it was time for their voices to be heard.
Similar movements are still alive around the world. Women continue to raise their voices to bring attention to the most critical issues facing our communities, and our world at large. Empowering women to help reduce poverty, build economic growth, improve nutrition and engage politically are vital to the security of our communities.
However, at home and abroad, women still face challenges. For women in the U.S., a more equal future still means securing equal access to quality and affordable health care; equal pay with men, who still earn on average 33 cents more to the dollar than women; personal security and safety from gender-based violence; and full inclusion in public and political life.
Although New Hampshire made history in 2012 by making us the first state to send an all-female congressional delegation to Washington, D.C., and in the last elections we celebrated the historically highest number of women in Congress, women still hold less than 19 percent of the seats, lagging far behind many other developed and developing nations.
Women both in the U.S. and around the world have been at the forefront of peace building – advocating for diplomacy rather than war, reaching across political, ethnic and religious divides to bring communities together and addressing the root social causes that often lead to today's conflicts. We know that women play a crucial role in creating and implementing sustainable solutions to conflict.
On this Women's Equality Day, with continuing violence in countries such as the Central African Republic, Nigeria, Syria and South Sudan, concerns over the rights of women in Afghanistan as the U.S. withdraws, and renewed violence in Iraq, just to name a few, it is more important than ever to make sure that women's voices are heard.
Women around the world today are still carrying the torch that Lucretia Mott and Elizabeth Cady Stanton lit 166 years ago. This year, in recognition of Women's Equality Day, join with me to urge our members of Congress to pursue inclusive diplomacy over war and pass the Women, Peace and Security Act, which would ensure women's full and meaningful participation in all of our diplomatic, development and defense efforts at home and abroad. Let us make sure that women's voices are heard on the most important issue of all – peace.


text:
Next: ax_prog_mysql, Previous: ax_prog_md5sum, Up: The Macros
This macro searches for a modprobe command, such as can be found on Linux systems with loadable kernel module support. PATH is checked first, then the default location(s).
This is one of several autoconf macros intended to assist in configuring and installing loadable kernel modules.
Download the latest version of ax_prog_modprobe.m4 or browse the macro's revision history.
Copyright © 2008 Kaelin Colclasure firstname.lastname@example.com
Copying and distribution of this file, with or without modification, are permitted in any medium without royalty provided the copyright notice and this notice are preserved. This file is offered as-is, without any warranty.

subset: commoncrawl


text:
American Legion supports Obama's plan to deploy veterans to revive economy WASHINGTON, Sept. 8, 2011 /PRNewswire-USNewswire/ — Pressing Congress to pass the American Jobs Act, which aims to reduce unemployment and stimulate U.S. productivity, President Barack Obama told a joint session of Congress Thursday evening to look to the nation's veterans, who have fought with their lives to defend our… Read more
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text:
Has Fulltext
- yes (1)
Is part of the Bibliography
- yes (1)
Year of publication
- 2014 (1) (remove)
Document Type
- Journal article (1)
- English (1)
- Chirurgie (1)
E7080 (Lenvatinib), a Multi-Targeted Tyrosine Kinase Inhibitor, Demonstrates Antitumor Activities Against Colorectal Cancer Xenografts (2014)
Clinical prognosis of metastasized colorectal carcinoma (CRC) is still not at desired levels and novel drugs are needed. Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro and human CRC xenografts in vivo. The effect of E7080 on cell viability was examined on 10 humanCRCcell lines and humanendothelial cells (HUVEC). The inhibitory effect of E7080 on VEGF-induced angiogenesis was studied in an ex vivo mouse aortic ring angiogenesis assay. In addition, the efficacy of E7080 against xenografts derived fromCRC cell lines and CRC patient resection specimenswithmutated KRASwas investigated in vivo. Arelatively low cytotoxic effect of E7080 on CRC cell viabilitywas observed in vitro. Endothelial cells (HUVEC)weremore susceptible to the incubation with E7080. This is in line with the observation that E7080 demonstrated an anti-angiogenic effect in a three-dimensional ex vivo mouse aortic ring angiogenesis assay. E7080 effectively disrupted CRC cell-mediated VEGF-stimulated growth of HUVEC in vitro. Daily in vivo treatment with E7080 (5 mg/kg) significantly delayed the growth of KRAS mutated CRC xenografts with decreased density of tumor-associated vessel formations and without tumor regression. This observation is in line with results that E7080 did not significantly reduce the number of Ki67-positive cells in CRC xenografts. The results suggest antiangiogenic activity of E7080 at a dosage thatwas well tolerated by nudemice. E7080 may provide therapeutic benefits in the treatment of CRC with mutated KRAS.


text:
null-contributing-item-policy attribute determines how the composite repository should behave if it tries to get the value of a property from a contributing repository item, but the repository cannot find a contributing item that links with the primary item. There are three possible behaviors:
If there is no contributing item found, a
RuntimeException is thrown.
If there is no contributing item found, the default value for that property in the contributing item descriptor is returned. If there is no default value, null is returned
If there is no contributing item found, null is returned automatically.


text:
Sara Lance is White Canary, the leader of the Legends. She is the younger sister of Laurel Lance and in the past also operated as The Canary and Black Canary.
Sara Lance is the daughter of Dinah Lance and Starling City police captain Quentin Lance. She is the younger sister of Laurel Lance.
Sara and Oliver on Queen's Gambit.
At one point, Sara began secretly seeing Laurel's playboy boyfriend, Oliver Queen, with only her mother aware of the affair. Oliver invited Sara to join him on his sailing trip with his father, Robert Queen, on their yacht Queen's Gambit. Against her mother's wishes, she agreed. That night, while they contemplated the consequences of their relationship, the sabotaged ship began to sink. While Sara seemed to have been the first casualty, with Oliver unable to do anything as he watched her sink and apparently drown, Oliver, Robert, and a third crewman were able to escape in a life raft.
As it turned out, Sara survived in the wreckage, and, after a stay on Lian Yu with Anthony Ivo that led her to ally with Oliver and his allies. Eventually, she was found by Nyssa al Ghul some time later, and trained by the League of Assassins in Nanda Parbat under the new name "Ta-er al-Sahfer" (yellow bird). During this time, Sara and Nyssa became lovers.
Sara Lance as The Canary.
Six years after the incident, Sara returned to Starling City, wanting to make sure that her family was safe after the earthquake that hit the Glades, and also wanting to leave her life as an assassin for the League behind while she still could consider herself a good person. Teaming up with the Arrow (who she knew to be Oliver), she killed Dollmaker, Al-Owal, and various other members of the League of Assassins before leaving to protect her family.
When her sister Laurel was poisoned with snake venom by the League of Assassins, Sara returned to Starling City, where she met with Nyssa once again, who was under orders from her father Ra's al Ghul to kill her former lover. However, Nyssa's true goal was to bring her ex-girlfriend back to Nanda Parbat and the League. Kidnapping Sara's mother while her sister was recovering in the hospital, Nyssa gave Sara 24 hours to come back to the League or she would kill Dinah. Nyssa released Dinah when Sara arrived with her father. She was happy to see Sara back, only to be shocked to see Sara had taken the same venom given to Laurel, which was also a poison on the League of Assassins members with Nyssa in case of capture. In the ensuing battle, the Arrow overpowered and nearly killed Nyssa, but the dying Sara pleaded for her release. In return for her would-be final act and the apparently continued love she had for her savior, Nyssa released Sara from her vow to be with the League, and left Starling City. Not long after, Sara was nursed to health with herbs from Lian Yu, afterwards meeting with her family (including Laurel, who rejected her), and apparently beginning a relationship once more with Oliver.
After aiding in the fight against Slade Wilson's Mirakuru army, Sara returned to Nanda Parbat and the League of Assassins, giving Laurel her jacket as a remembrance. A little later, Sara returned to Starling City, only to be killed by Thea who was under the influence of a drug by Malcolm Merlyn. Sara's death caused Laurel to use her anger and rage to become a new vigilante, the Black Canary.
Sara among Legends.
After discovering the existence of the Lazarus Pit, Laurel brought Sara back to life. Initially coming back as a soulless creature, John Constantine returned Sara's soul to her body. Sara begins a life of solitude in Tibet before being invited by Rip Hunter to his crew aboard the time traveling ship, the Waverider.
Sara Lance as White Canary.
When Rip became missing in action after the Legends were scattered throughout time, Sara became the new team leader and Captain of the Waverider.
She mercilessly hunted her sister's killer Damien Darhk, throughout history, before accepting she could not bring Laurel back. In the Invasion! crossover event, Sara returned to 2016 to support Oliver and the Flash in repelling the Dominators' alien invasion, and met the Kryptonian hero Supergirl from the parallel universe of Earth-38.
Some time later Sara was forced to use the godlike Spear of Destiny to save reality from the Legion of Doom. While tempted to rewrite her own tragic history, the Spear briefly reunited Sara with Laurel in the afterlife, who encouraged her to do what's right and makes peace with her death; she chose to render the Spear itself inert, foiling the evil plans of Eobard Thawne and allowing him to be killed by the Black Flash, who had been hunting him since he escaped Flashpoint.
Malice controls White Canary.
After several months staying in 2017 Sara resumed leading the Waverider crew as they tracked down and repaired anachronisms throughout time, working in a loose partnership with Rip Hunter's bureaucratic new organization, the Time Agency. Soon after resuming control of the Waverider, she attended Barry Allen and Iris West, where she had a one-night stand with Supergirl's foster sister Alex Danvers. Working together with assembled heroes, the team repealed an invading army from the Nazi world of Earth-X. Later, while confronting the demonic entity Mallus alongside her old friend John Constantine, Sara and Constantine hooked up, despite her ongoing romantic tension with Time Bureau agent Ava Sharpe. Constantine warned the Legends that Mallus would at some point take possession of Sara.
This project page needs to be cleaned up.
This article needs maintenance and organization, as it may have become cluttered or confusing. Its heart is in a good place, it's just a little special. Won't you please help out an article in need? This template will categorize articles that include it into the Clean Up task category.
Powers and Abilities
- Precognition (Formerly)[9]
- Martial Arts
- Archery: Although specializing in use of a staff that can separate into two sticks, Sara shows expertise with a bow the times she uses one.[11]
- Multilingualism: Fluent in English, Chinese,[2] and Arabic.[12]
- Acrobatics[13]
- Peak Human Condition
- Leadership[14]
- Firearms[15]
- Piloting: Sara is able to fly the Waverider.[16]
- Stealth
- Sonic Device: (Formerly) A handheld non-lethal Sonic weapon used to disable large groups of people. It overwhelms the hearing of everyone in the immediate vicinity, and is also capable of shattering glass.
- Waverider
- Motorcycle (Formerly)
- Expandable Baton: As White Canary, she uses a pair of expandable batons to fight. They are able to combine into a bo-staff.
- This version of the character is exclusive to the continuity of the television series Arrow, its tie-in comic book series, and its related television series. It is an adaptation of White Canary. The original character was created by Gail Simone and Ed Benes and first appeared in Birds of Prey (Volume 2) #1.
- Sara Lance was portrayed by Jacqueline MacInnes Wood on the pilot of Arrow, and by Caity Lotz in season two and onward.
- 144 Appearances of Sara Lance (Arrowverse)
- 15 Images featuring Sara Lance (Arrowverse)
- 11 Quotations by or about Sara Lance (Arrowverse)
- Character Gallery: Sara Lance (Arrowverse)
- ↑ Arrow (TV Series) Episode: Broken Dolls
- ↑ 2.0 2.1 Arrow (TV Series) Episode: League of Assassins
- ↑ DC's Legends of Tomorrow (TV Series) Episode: Camelot/3000
- ↑ The Flash (2014 TV Series) Episode: Fury Rogue
- ↑ DC's Legends of Tomorrow (TV Series) Episode: The Getaway
- ↑ DC's Legends of Tomorrow (TV Series) Episode: Hey, World!
- ↑ "Batwoman (TV Series) Episode: Crisis on Infinite Earths: Part Two"
- ↑ "DC's Legends of Tomorrow (TV Series) Episode: Slay Anything"
- ↑ 9.0 9.1 "DC's Legends of Tomorrow (TV Series) Episode: Ship Broken"
- ↑ "Pilot, Part 1"
- ↑ Arrow (TV Series) Episode: Crucible
- ↑ "Heir to the Demon"
- ↑ DC's Legends of Tomorrow (TV Series) Episode: Shogun
- ↑ "The Justice Society of America"
- ↑ Arrow (TV Series) Episode: Lost Souls
- ↑ "Compromised"
- ↑ "Vendetta"
- ↑ "Year's End"
|Team Arrow member
This character is or was a member of the Green Arrow family of vigilante super-heroes, who fight crime using archery and martial arts. They are a loose connection brought together through family bonds and shared experiences. This template will categorize articles that include it into the category "Team Arrow members."
League of Assassins member


text:
A Data Recovery Software - QR for CD
|Free to try
|Op. System:
|Last updated:
|4 Jan. 2007
|File size:
|Unistal Systems Pvt Ltd.
Publisher description for A Data Recovery Software - QR for CD
Quick Recovery CD is a non-destructive, simple and easy to use data recovery software, supports all types of Compact Disks, having multi-disk and multi-lingual support, simulates previously existing partitions and is read-only i.e. the program will never attempt to write to the drive to recover. Its unique Guided File Excavation Technology (GFETch) helps in locating files and folders, by doing a complete scan of all sectors to locate and extract the data, lost behind overwritten partitions and even if bad sectors hinder drive access. An exhaustive scan of the drive is performed to locate lost data. If data gets lost due to virus attack, bad sector, disk crash, etc., cause a business disaster then Quick Recovery is the best solution to rescue because it recovers/repairs almost all recovery cases encountered since 1993. Its features include: FEATURES It recovers the data even if : • CD is not accessible due to Table of Contents corruption. • CD-R, CD-RW is Damaged. • Directory structure is Damaged. • Any Volume Descriptor is Bad. • CD has data but is unreadable. • System hangs while reading CD. • CD not readable in other CD drives. • Damage due to scratches, cracks etc. • Disk has data but is unreadable. • Extract files if system hangs while reading CD.


text:
Share your personal immigration stories & experience and help other.
Use this control to limit the display of threads to those newer than the specified time frame.
Allows you to choose the data by which the thread list will be sorted.
Order threads in...
Note: when sorting by date, 'descending order' will show the newest results first.
Forum Rules


text:
Ambrym is a relatively unspoiled island famous for its volcanoes (Benbow and Marum) and handicrafts (tamtams and carvings). Ambrym islanders are also said to specialize in black magic.
Adventurous travelers can hire local guides to lead the strenuous climb to the volcanoes in the center of the island. If you visit in August, be sure to attend a Rom dance ceremony, more common in villages on the northern part of the island. The costumes the dancers wear are simply amazing. 100 mi/160 km north of Efate.
Request Full Destination Guide
To request access to the full version of this destination guide, please provide your email address below. Your email address will only be used for verification purposes and will not be used for marketing purposes.
|Copyright ©2020 Northstar Travel Media LLC. All Rights Reserved.
Your Travel Specialist
Forever Vacations
Email: firstname.lastname@example.com
PO Box 1145
Dillon, Montana 59725


text:
Note: Sheena Easton was a pop star of the 1980s. We didn't know it at the time, but this tour probably marked the end of her ten years or so of popularity, though perhaps there were hints of that in the behavior of the crowd that night in August, 1989. This was the review:
The transformation of Sheena Easton from happy pop star
to pouting disco queen has been so complete and so radical
that it's almost enough to make a sensitive individual
cynical about life. One year she was safe, the kind of
singer that parents love and teenagers hate, singing songs
like "My Baby Takes the Morning Train." Next thing she was
belting, "Come spend the night inside my sugar walls" and
getting banned by radio stations.
"Some Senator's wife said I was a corrupter of
America's youth," she told the crowd at her Shoreline
concert Saturday night. "Let's face it. Dan Quayle is more
dangerous to this country than I am." That's right, Sheena.
Come here from Scotland and tell us our problems.
It was small crowd at the Shoreline Amphitheater, maybe
one third capacity at best (Easton played the Concord
Pavilion on Saturday). But the 90-minute show had its
moments. Easton has a good, strong voice and comes across as
both self-possessed and quirky on stage — an intelligent,
thoroughly respectable young lady, who just happens to be
wearing a dress you can hide under your shoe.
Easton benefits from having a particularly hot disco
band, seven pieces, including three keyboard players. Songs
that I might never listen to on record, like "One Love" or
"Days Like This" from her latest album, jumped in
The show got off to a dumb and surprisingly undramatic
start. A man-sized cardboard heart was in the middle of the
stage, while over the loud speakers played a recording of
Easton trying to place a phone call. The bit went on too
long, so that by the time the heart was lifted and Easton
was revealed, singing "Telefone (Long Distance Love
Affair)," the cheering was fairly subdued.
Easton wore a purple mini-dress and high heels, and her
red hair is straight and shoulder-length. She looked sexy
and proper. "I was just in my dressing room, drying my hair
and thinking, `There's a live audience out there!"' she
said. Quiet blow-dryer, I guess.
In between the dance tunes, she threw in a few ballads:
"I Wouldn't Beg for Water" and "Follow My Rainbow." She
made a medley out of "Morning Train" and "Modern Girl,"
her first hits. "It's hard to believe Tiffany and Debbie
Gibson were in grade school when I did this."
Easton has an odd and characteristic way of dancing.
She's not Debbie Gibson, hopping on one foot for two hours.
Her gestures are small, subtle and slow. She puts her right
foot in. She puts her right foot out. She puts her knees
together and dips and wriggles but ever so slightly. Somehow
she manages to suggest that these small gestures are just
the tip of some great iceberg of passion.
Several of Easton's dance cuts were choreographed,
including "No Deposit, No Return," which I thought was
about conception and childbirth until I read the lyrics.
While her female back-up singers waved their arms on either
side of her, Easton stood in the middle doing the same
moves, but calmly.
The sameness of the music made the show drag at times,
despite the black mini-skirt and halter Easton changed into
midway. At one point an electric fan that was on the side of
the stage blew Easton's skirt up around her waist. Shades of
Marilyn Monroe. "Turn this thing down, it's disgusting!"
she barked at a roadie. I'd hate to get on Easton's bad
The best number of the night was the controversial
"Sugar Walls," a genuinely charged song. The band gave it
the full treatment, heavy on the bass, while Easton rubbed
her tummy, wiggled and pouted. I don't know what she was
doing, but it looked good. She closed the show with "For
Your Eyes Only" and her single, "The Lover In Me."
I thought the crowd, which was oddly relaxed Saturday
night, might leave before the encore. But they brought back
Easton for "Strut" and "Wind Beneath My Wings." Easton
put her arms out, as though she had wings, thanked the crowd
and said "Good night."
I've seen worse shows catch fire, but somehow this one
never did, and it's hard to figure why. The audience
remained in their seats the whole show, and walking out
there was none of that usual after-the-concert carrying on.
Outside in the parking lot, an employee at the Shoreline was
laughing. "This is too quiet, people," he said. "It's
really weird, guys, I'm telling you."


text:
Reg: $179.94
This product is
out of stock
Contact your dedicated Wine Specialist directly or email Customer Service:
Contact us
Wine consultation
Contact us
Wine consultation
Taittinger Prelude - 750ML
2006 Billecart-Salmon Nicolas Francois Billecart Vintage Brut - 750ML
Bollinger Special Cuvee - 750ML
Gosset Grand Reserve - 750ML
Laurent-Perrier Brut - 750ML
Dear Customer
We are having problems processing your request.
Please contact our sales office between 9 AM and 5 PM (PST) for further assistance at 1.888.859.4637.
I purchased a lot from JJB when I previously lived in California... Always better prices and they'd hold bottles until I put together cases to ship. Great customer service. I moved to Italy 4 years ago and was out of the loop, but I'm back and happy to go with JJ!
-Joseph S., June 2017


text:
New York, Jan 13: Music maestro A R Rahman on Monday scripted history by becoming the first Indian to win the prestigious Golden Globe award for best original music score for Mumbai-based saga 'Slumdog Millionaire,' with the film hitting the jackpot bagging honours in four categories.
A Mumbai underdog's rags-to-riches story directed by British filmmaker Danny Boyle, the movie swept awards in all the four categories it was nominated for, brightening its chances at the Oscars next monthLiving up to its reputation of an underdog-winner tale, the 'Slumdog' has emerged a favourite in almost all the pre-Oscar award ceremonies. It has already won the the best film, best director for Danny Boyle, best writer for Simon Beaufoy, best young actor for Dev Patel and best composer award for A R Rahman at the 14th annual Critics Choice Awards by Broadcast Film Critics Association's of America last week.
Boyle's film depicts the heart-warming story of an orphan Jamaal, who goes on to win the Indian version of popular game show 'Who Wants to Be a Millionaire? to get his love back. The film was adapted from Indian diplomat Vikas Swarup's novel 'Q and A' .
Taken from http://www.daijiworld.com/news/news_disp.asp?n_id=55657&n_tit=A+R+Rahman+Becomes+First+Indian+to+Win+
I have not seen this movie. You can watch it online.
Tuesday, 13 January 2009
Golden Globe for Slumdog Millionaire
Posted by Amrita at Tuesday, January 13, 2009
Labels: Celebrating India
6 Fertilize my soul:
- The Dementia Nurse said...
Hello Amrita! This movie is playing here now; with all of the awards, I am guessing it will play for a while. I'm looking forward to seeing it sometime this week. I will be thinking about you the whole time!
- 13 January 2009 at 21:51
- Sita said...
This movie is making the news the news here too--and there is a large South Asian population in Toronto, so I expect it will run for some time.
Hope all is well with you. Are you back 'up to speed' yet? This weekend is a conference on child sex slavery, focusing on Cambodia, and sponsored by Ratanak Foundation and IJM. I know the issue affects India as well. Heartbreaking.
Also making the news here is an Indian woman killed by her FIL over a dowry issue. So sad, she was so young , with a young son, and she was horribly treated since she came to live with her new in-laws.
Thank you, Lord, for Jesus, and the Hope He brings to a dying world.
Blessings, Amrita
Love, Sita
- 13 January 2009 at 23:20
- Jan said...
I'm so glad u like mexicomusings! I'm having fun w/ videoing now. All encouraging words help! So, please advise us when u see Slumdog Millionaire. I'm hoping perhaps 2 see soon. (pardon, compu is missing some kes.)
- 14 January 2009 at 10:10
- Michelle said...
I simply LOVE movie trailers. I am the person who goes early to the theatre to make sure I can see them and don't talk during them or I will ask you to be quiet. This is how I decide if I will see a movie or not. Unfortunately I don't go to the movies in Ukraine so I rarely get to see trailers.....I love that I can watch them on the internet now! This movie looks awesome and I will definitely look for it even if it's on DVD!
- 14 January 2009 at 17:44
- Amrita said...
Hi Gail, see the movie andtell us what its like. its not released yet in Imdia.
Yeah Sita, everyday we read stories about crimes against women and children. Dowry killings are common here , although there are strict laws against them and people get punished too.
Hi Jan, the Mexico videos are very captivating. its like dropping by for a virtual visit.
Hi Michelle,
I too don 't go to movie theaters. Ususally watch movies on TV. I 'd like to watch Slumdog on DVD sometime if its available.The trailer is quite good.
- 15 January 2009 at 18:33
- Amrita said...
Oh yes Sita I am much better now. Up and about if you please.And praise God Aunt Viginia was discharged from hospital last night so that is an added boost.
My washing machine busted a few days ago and after a lot of trys a man came to look at it. Timer has to be replaced . i gave him the money to buy it, hopefully he will do the job today or tomorrow.
- 15 January 2009 at 18:37


text:
Probation Report: Lindsay Lohan Just Won't Change
Lindsay Lohan's probation officer thinks she's a spoiled brat and asked the court to lock her up in jail -- because she wouldn't change her partying ways.
The probation report which was submitted to Judge Stephanie Sautner ... indicates Lindsay failed an alcohol test on June 13 -- the day after she was seen partying on her rooftop deck in Venice, Ca.
It also states Lindsay refused two prior narcotics tests -- on May 31 and June 2 -- and passed another on June 9.
LiLo's probation officer writes, "The defendant's behavior indicates she is not attempting to change. It appears that the defendant does not view being on the electronic monitoring program as a privilege.
The report goes on to recommend Lindsay should serve "suitable time in custody."
Of course, we now know Lindsay should NOT have been tested at all ... since the order requiring testing expired on February 25.
Waiting for your permission to load the comments.


text:
Lynette Hoppe
Lynette (Katherine) Hoppe was an Orthodox missionary to Albania serving under Archbishop Anastasios. A graphics designer, she published the book Resurrection: The Orthodox Autocephalous Church of Albania: 1991-2003. Suffering from breast cancer, Lynnette joined her Lord on August 27, 2006. She left behind her loving husband Nathan and two beautiful children, Tristan and Katherine.
Further reading
- Lynette's Hope: The Witness of Lynette Katherine Hoppe's by Fr. Luke Veronis. ISBN 1888212993
External links
- "A Christian Witness of Living and Dying, in Honor of Lynette Hoppe" by Fr. Luke Veronis, OCMC Mission Magazine, Fall 2006, pp. 8-9.
- The Hoppe Albanian Mission / Pray for Lynette
- Resurrection 1991-2003: The Orthodox Autocephalous Church of Albania by Lynette Hoppe. Foreword by Archbishop Anastasios: listing at Light & Life Publishing.


text:
I know it seems far-fetched, but there's a constant stream of humor in the technology industry, and my aim each month is to dig it up--and even if it's not really there, to ridicule it anyway. Like Microsoft buying AOL patents (one can imagine what they'll do with AOL's hold on the ability to stuff magazines with CDs), or AT&T changing its slogan (to "it's what you do with what we do" which is, frankly, pretty silly) or T-Mobile spokeswoman Carly tossing aside her innocent image for a Ducati and motorcycle leathers.
What could be more interesting than the Masters golf tournament snubbing new IBM CEO Virginia Rometty, or Republican nominee-in-waiting Mitt Romney's use of Google+ Hangouts? How about an Oregon man stripping naked at an airport TSA checkpoint to protest what he felt was a violation of his privacy--perhaps users of Facebook and other social networks want to take note?
There might be nothing funny about Big Data, except that it now seems to be the answer to every question being asked in IT right now; in other words, it's become the most hyped technology of 2012, and that makes it ripe for ridicule.
Don't believe me? Watch me have a little fun with all of this in the video below.


text:
If you have a pest problem, before you hire an exterminator find out what you can do on your own. This article describes the most common household pests and offers tips for eliminating them. Except for termites and bedbugs, you should be able to cure most pest problems without hiring a service.
If you need expert assistance, our ratings of area pest control services will help you find it. Several outfits were rated quite highly by their surveyed customers, but some companies received unfavorable ratings from large percentages of their customers.
Prices for household pest treatments also vary widely. While some companies charge $125 or less for a single treatment for cockroaches, others charge $250 or more. Some companies require their customers to sign up for long-term contracts that cost $400 or more. But for most household pests, a single treatment done properly should do the trick.
Don't assume you have to pay more to get good work: Our evaluation revealed no relationship between prices charged for pest control work and customer satisfaction.
If you suspect you have a termite problem, get several inspections because some companies have been known to recommend treatment when there is neither an active infestation nor serious threat of one.
Check the guarantees offered by companies you are considering. Will they pay for pest damages or just re-treatment? How often will they come over to inspect at no extra charge? And what do you have to do to keep the guarantee in effect?


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TOKYO - The future of Apple Inc's supply chain for its flagship smartphones has come under industry scrutiny as people familiar with the matter said Apple is in talks to buy control of a Japanese venture that makes key semiconductors for its iPhone screens.
The talks on what would be a rare acquisition in Japan for the U.S. technology giant come as competition heats up in the smartphone industry, with pressure to produce larger, sharper and less battery-draining screens. That makes the advanced chips made by the Renesas Electronics Corp division all the more valuable in future.
Renesas, a loss-making Japanese chipmaker that is restructuring to focus on its core auto business, is also in talks with other companies on selling its 55 percent stake in the chip division, known as Renesas SP Driver, people familiar with the matter said on Wednesday. The people did not name the other companies, nor indicate the current status of the talks.
Desire for control over a venture that makes all the display control chips for the iPhone as Apple battles rival products from the likes of Samsung Electronics Co Ltd makes a compelling case for Apple to seek a deal, industry officials and analysts said.
"It (Apple) certainly might not be happy that someone else might want it (the venture)," said Damian Thong, analyst at Macquarie.
"Apple routinely buys in key technology components and software which they feel are important for the development of their products. It's not new. What is unusual is that they're doing it in the context of a Japanese firm."
Renesas said on Wednesday it was considering selling the Renesas SP Driver unit, but declined to comment further.
Apple did not respond to an email seeking comment.
The Nikkei business daily, which was first to report on the talks, said Apple could buy the Renesas stake for 50 billion yen ($483 million) by summer. It added that Sharp Corp could also sell its 25 percent stake if requested to do so by Apple. Taiwan's Powerchip owns the remaining stake.
Shares of Renesas surged after the report by as much as 19 percent to 934 yen, their highest in more than three years. They pared those gains to end up 6 percent at 831 yen, compared with a 1 percent rise in the benchmark Nikkei average.
A deal by Apple would be a rare foray into a Japanese technology industry that has suffered from aggressive competition by ambitious rivals like Samsung Electronics in the last decade.
Renesas, formed from struggling chip units at conglomerates Hitachi Ltd, Mitsubishi Electric Corp and NEC Corp, has racked up nearly 650 billion yen ($6.28 billion) in net losses over the last eight years.
Sharp has also posted heavy losses in recent years.
Renesas SP Driver, the largest maker of chips used to control mobile device screens, supplies all three of the companies that make displays for the iPhone, industry sources say: Sharp, Japan Display Inc and South Korea's LG Display Co Ltd.
"There's no doubt that, for Apple, the question of who buys Renesas SP is a matter of grave significance," said one Japanese display industry source, who asked not to be identified due to the sensitivity of the matter.
Control over the supply chain has become increasingly crucial among smartphone makers. While up to now Apple has relied on outside suppliers for many key parts, Samsung Electronics makes vital parts for its Galaxy smartphones, from screens to chips to capacitors, in-house. That gives it greater control over costs, production schedules and specifications, as well as product information.
The business at the centre of the talks has its admirers, industry watchers say,
"Renesas SP Driver is strong in technology for LCD (panel drivers," said one industry analyst, who declined to be named. "Other driver makers can't catch up to its technology," he said, emphasising its strength in high resolution and power-saving features.


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E: firstname.lastname@example.com: (+44) 020 3411 5439
Opening HoursMonday to Friday09h00 to 13h00
Weekends Closed
Closed Bank Holidays
Thinking of doing a ski season yourself? See our jobs page for more information!
It is with
great regret that we have taken the decision to cease trading effective from
Monday the 30th November 2020.
We would like
to thank all of our loyal clients who have chosen us to take their holidays
with over the years, along with the staff who have worked hard to provide our
clients with the very best holidays.
If you have a
holiday booked with us for the coming season, then further information can be
found on ABTOT's website here - https://www.abtot.com/advice-for-customers-of-time-of-your-life-travel-limited-t-as-ski-amis/. If you paid by card then you should contact
your card issuer to raise a section 75 chargeback claim and if you paid by bank
transfer then you should submit a claim to ABTOT.
We have tried
very hard throughout this period however unfortunately we are left with no
other alternatives but to take this very difficult step and we are so very
sorry to everybody affected.
We have been providing quality catered chalet holidays in France at value for money prices for nearly 30 years now. We believe that our guests deserve to be well looked after, no matter which holiday they choose - we strive to provide an excellent level of service in our catered chalets and also with our range of self catered ski holidays. For those who prefer independence we have thousands of privately owned properties available from small apartments to large luxury chalets.
As a family business, our concept is to care for each and every guest individually. We provide a ski chalet package which is as flexible as possible to your individual needs. We have a range of different accommodation options - catered chalets and self catered ski holidays - flexibility to travel to the resort in whichever way you choose and a full in-resort service so you can pay for what you need or want and not what you don't! Many people think it's cheaper and easier to book an all inclusive package - but with Ski Amis we will do all the leg work for you to make up your own personalised holiday at the best price possible - so why not let us give you a bespoke holiday for a package price.
Our unique recruitment and training approach for our catered chalet staff and our high standard fixed menus means that you can be guaranteed of the same good standards which of our catered chalets you choose and whichever year you travel! Our teams constantly receive the same good feedback ... read our review page to see what our guests say about us year after year.
Our efforts have been recognised with several industry awards and nominations over recent years - last year winning the "Best Ski and Winter Sports Holiday Company (Small)" category, and being a finalist in the "Best Small Holiday Company for Customer Service" category at the British Travel Awards 2015. The Awards are the "Oscars" of the travel industry, based purely on consumer voting. We were also nominated for the Daily Telegraph World Snow Awards 2015 in the "Best Chalet Operator" category and have twice before been part of the British Travel Awards with a nomination in 2012 and as a top 3 finalist in 2013. In 2013, we were also awarded joint winner of the "Best Ski Tour Operator" category in the Snowvole Awards 2013.
Cookies are small files stored in your browser and are used by most websites to help personalise your web experience. Some features on this site will not function if you do not enable cookies.
Once you click the "Disable" button a small cookie is used to store your cookie preferences. The "Disable Cookies" bar will be hidden for the remainder of your session.Cookie used: allowCookies
Analytical cookies allow us to recognise and count the number of visitors to our website, and to see how visitors move around the site when they are using it. This helps us to improve your website experience and the services we provide. No personal information is collected about you or about your computer.Cookies used: __utma, __utmb, __utmc, __utmz
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For additional information on cookies please check out the Information Commissioner's Office. More Details


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Curved Stairlift Suppliers in Sheffield
Going around the bend trying to find affordable curved stairlifts suppliers in Sheffield?
Look no further than Top Flight Stairlifts – Specialist in Curved Stairlift installations in Sheffield and surrounding areas.
You may need to consider purchasing a curved stairlift if your staircase has a turn or curve in it, and also depends on the layout of the staircase. If the staircase has a sweeping curve or multiple places where the staircase changes direction, you will require a curved rail stairlift.
Call Sheffield 0114 358 9611 for a Curved Stairlift Price
Why Choose Top Flight Stairlifts for Curved Stairlifts?
- Over 10 years' experience in the stairlift & mobility industry
- Straight stairlifts and curved stairlifts
- Reconditioned stairlifts and rental stairlifts
- Unbeatable warranties (on new and used stairlifts)
- 24 hour call out on servicing and maintenance
- Daily living aids
- FREE Home visit quotations available
Find out more about our stairlift company click here.
How much does it cost to install a curved stairlift in Sheffield?
Curved stair lifts are more expensive as they require custom building and will take longer to install than a straight stairlift. They are more complex in that the bending rail system follows the contours of the staircase, and this requires a more sophisticated and very accurate survey of the staircase to ensure the system is crafted and installed to meet the exact requirements.
Top Flight Stairlifts specialise in the supply, maintenance and installation of curved stairlifts in the Birmingham area, call one of our staircase experts on Sheffield 0114 358 9611 today.
As the specification is far greater than that of a straight stairlift and is also dependent on the specification of your staircase, manufacture can take anywhere between 5 and 7 days before delivery. This short delivery timescale is considerably quicker than other suppliers.
Installation requires two highly skilled stairlift technicians who will carry out the installation easily within one day.
Curved Stairlift Installers in Sheffield 0114 358 9611


text: On Saturday, April 6, 2019, our team will join the thousands of SUPERHEROES at the 15th annual Race for Autism in Balboa Park. It's going to be "Super!" As you know, this cause is very dear to me. Autism affects 1 in 59 children in the US today, and over 19,000 individuals right here in San Diego. 100% of the dollars we raise stays in San Diego to help our community, providing funding for autism treatment programs, vocational training for young adults, parent programs, educational workshops, and funding to hundreds of local classrooms. The funds raised at the Race benefit thousands of San Diego children and families each year. Every dollar truly makes a difference at improving the learning, social and employment opportunities for our children. Please join our team and give as generously as you can. Your support is greatly appreciated! Together, let's be Heroes for those with autism! Wyatt Michael


text:
In today's economic climate, it's not uncommon for employees to take on new roles, whether or not they're qualified. To the budget people upstairs, this may sound like a wonderful idea. In real life, the benefits of such a strategy do not always translate.
I saw this for myself a couple of years ago while working for a major company at its North American headquarters -- coincidentally, where the organization's CEO and everyone else at the top of the corporate food chain were stationed as well.
[ Also on InfoWorld: Peer into the secrets behind IT magic tricks and more networking know-how in Paul Venezia's The Deep End blog. | Follow InfoWorld's Off the Record on Twitter for tech's war stories, career takes, and off-the-wall news. | Subscribe to the Off the Record newsletter for your weekly dose of workplace shenanigans. ]
IT management at the company didn't treat any of their staff well, but the employees in this location were consistently handled like the proverbial stepchildren. New IT staff would come in on a temp-to-hire basis, assume the job responsibilities of three people, run full steam ahead until they burned out, and then quit/get fired. Very few actually made it to the point where they were hired on full-time. Even if they did, they usually didn't last much longer since the pressure only got worse.
When I arrived, I found that the only other IT staff member had been there a mere two months with minimal training. The last full-time IT person had left a month before, so she'd been on her own since and was frazzled beyond words.
Not only were we overworked, but the users at this site were some of the neediest and most demanding backstabbers you could find anywhere. Add to that a ridiculously complex configuration for the machines, file synchronization that never worked, roaming profiles that corrupted at least once a week for each user, and servers that were less stable than a 20-something former child star.
We were hired as the local IT staff for the usual desktop support responsibilities. The offsite tier 3 support team was responsible for managing the servers and network equipment.
After a couple of the employees burned out and another was fired, the director of IT came up with a brilliant idea that would save the company all sorts of money: He would have the local IT support people be responsible for server and networking equipment at the headquarters.
In theory I'm sure this sounded like a great idea, but in practice he was begging for trouble. I had some server experience from a previous job, so I was able to keep an eye on that. But the networking equipment -- fuhgeddaboudit. I didn't even know what each piece of equipment did, much less how to troubleshoot it. They were simply magical boxes with twinkling lights that made stuff work.
When I expressed my concerns to the director, he started with an empty promise to have someone from the network team "come down and show us some stuff." Then came a threat masked in all of the political horse crap he could muster: "We encourage all of the people that we hire to continue growing and bettering themselves, and this is what we would like to continue to see from you. So you can help the team out by taking on this role."


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Sildenafil to Treat HIV-Associated Pulmonary Hypertension
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00327080
Recruitment Status : Terminated
First Posted : May 18, 2006
Last Update Posted : December 17, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This study will examine how blood pressure in the lungs is controlled in healthy people, people with HIV and people with HIV and pulmonary artery hypertension (high blood pressure in the lungs, also called PAH). PAH sometimes develops in people with HIV, but it is not known why this occurs or how best to treat it.
Healthy volunteers and patients with HIV infection who are 18 years of age or older may be eligible for this study. All candidates are screened with a medical history, physical examination, electrocardiogram (EKG), chest x-ray, echocardiogram and blood tests. Participants undergo the following procedures:
All participants have a right heart catheterization and forearm blood flow study.
- Catheterization study. A catheter (plastic tube) is placed in an arm vein and possibly in an artery in the arm. Then a large catheter is passed through a vein in the groin, neck or chest. Through this "introducer" catheter, another catheter is advanced into the right side of the heart and to the pulmonary artery. A facemask is put in place to measure the amount of nitric oxide produced by the lungs. Acetylcholine is infused through the catheter and its effects on blood pressure in the lungs and on the amount of nitric oxide exhaled is measured. After about 1 hour, the catheter and facemask are removed and a new catheter is inserted through the introducer catheter into the pulmonary artery. The subject is moved into an MRI scanner where blood flow is measured after infusion of three different medications: acetylcholine (causes blood vessels to expand and slows heart rate); sodium nitroprusside (causes blood vessels to expand and increases blood flow to the heart); and L-NMMA (decreases blood flow by blocking production of nitric oxide in cells lining the blood vessels).
- Blood flow study. Small tubes are inserted into the artery of the patient's forearm. These are used to infuse medicines and draw blood samples. Forearm blood flow is measured using pressure cuffs placed on the wrist and upper arm, and a strain gauge (a rubber band device) placed around the forearm. When the cuffs are inflated, blood flows into the arm, stretching the strain gauge, and the flow measurement is recorded. A small lamp is positioned over the hand to measure the light reflected from the hand and blood flow in the forearm. Blood samples are then drawn to measure blood counts and proteins and other natural body chemicals. Then, forearm blood flow is measured after administration of small doses of sodium nitroprusside, acetylcholine and L-NMMA. There is a 20- to 30-minute rest period between injections of the different drugs.
In addition, HIV-infected patients with PAH undergo the following tests to determine the cause of their PAH: CT scan of the lungs, pulmonary function tests, 6-minute walk test, quality-of-life assessment, assessment of difficulty in breathing, exercise testing while measuring oxygen breathed in and carbon dioxide breathed out, blood tests, monitoring of oxygen saturation during sleep for 1 night and ventilation/perfusion scan. For the ventilation/perfusion scan, the subject breathes in a small amount of radioactive aerosol while images are obtained of the radioactivity as it enters the lungs, and then pictures of the lungs are taken from multiple angles. Next, the patient receives an injection of tiny particles of albumin (a protein) containing a small amount of radioactivity and pictures of the lungs are taken that show the pattern of blood flow to the lungs.
Patients with HIV and PAH who may benefit from the investigational drug, sildenafil (commonly known as Viagra), may continue to participate in the next stage of the study. They receive the first dose of sildenafil after completing the forearm blood flow study. They continue the drug for 16 weeks, returning to the clinic 1 week after the first dose and then every other week to monitor the response to treatment and drug side effects. At the end of 16 weeks, patients return to the clinic for a repeat evaluation, including blood tests, 6-minute walk test, echocardiogram, right heart catheterization and forearm blood flow study.
|Condition or disease
|Procedure: MRI Drug: L-NMMA Drug: Acetylcholine
|Phase 1
HIV infection has been associated with an increased prevalence of pulmonary hypertension. In addition, recent data suggests that a state of endothelial dysfunction develops in HIV disease secondary to anti-retroviral therapy and associated dyslipidemia or secondary to direct viral infection of the endothelium. This leads to premature atherosclerosis and possibly contributes to avascular necrosis of the hip. Similar effects on the pulmonary vasculature may be involved in the development of pulmonary vasculopathy.
In this study we plan to invasively characterize the status of pulmonary and systemic endothelial function and determine the mechanisms of pulmonary vascular endothelial dysfunction in HIV disease. To this end we will catheterize healthy volunteers and volunteers with HIV infection with and without pulmonary hypertension and directly measure acetylcholine-dependent blood flow in the pulmonary and brachial artery to assess pulmonary and systemic endothelium-dependent blood flow. Simultaneous measurement of exhaled NO and pulmonary capillary artery NO2 - will allow for complete characterization of the contribution of NO production to endothelium-dependent vasomotor control. We will also use recently developed MRI techniques to measure pulmonary artery blood flow during infusion of acetylcholine (ACH), sodium nitroprusside (SNP) and NG monomethyl-L-arginine (LNMMA) to establish responsiveness to an endothelium dependent vasodilator, endothelium-independent vasodilator and an NO inhibitor, respectively. Volunteers with pulmonary hypertension will have the option to undergo open label phase I/II treatment with sildenafil for 16 weeks and return for a repeat assessment of pulmonary hemodynamics as well as pulmonary and systemic endothelial function.
Endothelial cells will be isolated using novel flow-cytometry methodologies developed over the last two years at the NIH intramural division utilizing combinations of positive and negative selection based on specific surface markers for activated T cells and endothelial cells and markers of cell viability. Endothelial cells will subsequently be interrogated using amplified real time PCR methodologies and affymetrix based gene expression profiling developed in our laboratories. The levels of expression in endothelial cells of HIV virus, HHV8, eNOS, caveolin, HO-1, endothelin receptors A and B, and endothelin 1, in addition to other proteins regulating vascular homeostasis and cellular host defense (i.e. epidermal growth factor, transforming growth factor beta, platelet derived growth factor and interleukin-6), will be assessed.
These studies will provide insights into the mechanisms of pulmonary artery endothelial dysfunction and suggest rationally designed therapies targeting viral load, HHV8, and/or the NO/endothelin pathways. These studies have the promise of opening the door to the study of pulmonary artery endothelial dysfunction at the physiological, cellular and molecular level.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|20 participants
|Primary Purpose:
|Official Title:
|Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension
|Study Start Date :
|May 12, 2006
|Actual Primary Completion Date :
|March 18, 2009
|Actual Study Completion Date :
|March 18, 2009
- Evaluate pulmonary artery and systemic endothelial function in HIV infected volunteers with pulmonary hypertension in comparison to HIV infected volunteers without pulmonary hypertension.
- Evaluate the safety and efficacy of sildenafil in the treatment of hemodynamic and functional abnormalities in volunteers with HIV associated pulmonary hypertension.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
All volunteer subjects must be at least 18 years of age and must be able to provide informed, written consent for participation in this study. Eligibility in the study is determined prior to enrollment on the basis of the following inclusion and exclusion criteria.
For Healthy Volunteers:
- Males or females, 18 years of age or older.
- No history of HIV infection.
- EKG and echocardiogram with no evidence of clinical relevant heart disease (including TRV less than 2.5 m/s)
- No history of causes of pulmonary hypertension such as collagen vascular disease, chronic liver disease with ALT or AST greater than 2 times the upper limit of normal or cirrhosis of the liver, chronic thromboembolic disease, congenital heart defects, or pulmonary parenchymal disease with hypoxemia.
- No history of diseases thought to be related to development of endothelial dysfunction including systemic hypertension or diabetes requiring drug therapy, hypercholesterolemia and obesity.
- No history of anemia, thrombocytopenia or coagulopathy.
- No history of renal insufficiency.
No medical conditions requiring chronic medication use with the exception of:
- Heartburn, GERD
- Environmental allegeries, post nasal drip or non-allergic rhinitis
- Asthma with no history of oral steroid use, weekly inhaled steroids, or hospitalization for asthma exacerbation.
- Dermatologic conditions that do not require the use of oral steroids or other immunosuppressants.
- No more than 20 cigarettes per year for the previous 2 years and no cigarette use for 30 days prior to the screening evaluation until completion of the study.
For HIV Positive Volunteers:
- Males or females, 18 years of age or older.
- Diagnosis of HIV infection.
- Under the care of a primary care physician.
- No history of other potential causes of pulmonary hypertension such as collagen vascular disease, chronic liver disease with ALT or AST greater than 2 times the upper limit of normal or cirrhosis of the liver, chronic thromboembolic disease, congenital heart defects, or pulmonary parenchymal disease with hypoxemia.
- For stage 3 enrollment: symptomatic pulmonary hypertension with MPAP greater than or equal to 25 mmHg and six-minute walk distance between 150-450 m.
For Healthy volunteers:
- Current pregnancy, lactation or women not currently using medically acceptable birth control. (All women of childbearing age will be required to have a screening urine or blood pregnancy test)
Contraindication to MRI scanning including individuals with the following devices:
A) Central nervous system aneurysm clips
B) Implanted neural stimulator
C) Implanted cardiac pacemaker or defibrillator prior to enrollment
D) Cochlear implant
E) Ocular foreign body (e.g. metal shavings)
F) Insulin pump
G) Metal shrapnel or bullet
- Contraindications to MRI contrast agent administration:
- Inability to provide informed written consent for participation in the study.
- Chronic, medically refractory atrial tachyarrhythmias
- Symptoms of heart failure
- Mean PA greater than 25 mmHg or PVR greater than 1.5 wood units, or PCWP greater than 15 mmHg
- History of recreational drug use with the exception of marijuana. No Marijuana use within 3 months of protocol screening through completion of the study.
Volunteers may be excluded if in the opinion of the study investigators they have a condition that may adversely affect the outcome of the study or the safety of the volunteer.
For HIV Positive Volunteers:
- Current pregnancy, lactation or women not currently using medically acceptable birth control.
- Active, untreated opportunistic infection with the exception of oral thrush or neoplasm with the exception of Kaposi's Sarcoma.
Any of the following medical conditions:
A) Severe renal insufficiency (on hemodialysis or serum creatinine greater than 2.5 mg/dl) or (CrCl less than 20 ml/min).
B) Severe coagulopathy (platelets less than 100,000, PT INR greater than 1.5, PTT greater than 40 s)
- Chronic, medically refractory atrial tachyarrhythmias
- Current recreational drug use or use within 4 weeks of protocol screening with the exception of marijuana
Contraindication to MRI scanning including individuals with the following devices:
A) Central nervous system aneurysm clips
B) Implanted neural stimulator
C) Implanted cardiac pacemaker or defibrillator prior to enrollment
D) Cochlear implant
E) Ocular foreign body (e.g. metal shavings)
F) Insulin pump
G) Metal shrapnel or bullet
- Contraindications to MRI contrast agent administration:
A) Individuals with hemoglobinopathies
Volunteers may be excluded if in the opinion of the study investigators they have a condition that may adversely affect the outcome of the study or the safety of the volunteer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00327080
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Henry Masur, M.D.
|National Institutes of Health Clinical Center (CC)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|May 18, 2006 Key Record Dates
|Last Update Posted:
|December 17, 2019
|Last Verified:
|November 13, 2012
Pulmonary Hypertension
Blood Flow Studies
Right Heart Catheterization
HIV Infection
HIV Associated Pulmonary Hypertension
Healthy Volunteer
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Molecular Mechanisms of Pharmacological Action
Vasodilator Agents
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Physiological Effects of Drugs


text:
Maybe we should call the next 10 years the Decade of the Ultra-High-Net-Worth Individual. It's certainly a mouthful, but judging by the Knight Frank's Wealth Report 2014, it's accurate.
The report detailed the attitudes and trends of the richest of the rich, and one thing that stands out is the expected growth in their numbers by 2023. The U.S., which has the largest number of UHNW people, will see double-digit percentage growth. At the same time, countries with few in the category, such as Vietnam, will see spectacular growth in percentage terms.
See also: 8 tips for working with high-net-worth clients
For its report, which looked at charitable giving and luxury spending, among other metrics, Knight Frank surveyed 600 private bankers and wealth advisors that represent 23,000 ultra-high-net-worth individuals.
1. Biggest Risks to Wealth Creation
Global Economic Conditions: 33%
Local Economic Conditions: 19%
Local Political Situation: 18%
Local Taxation Conditions: 18%
Global Political Situation: 11%
2. Biggest Positives to Wealth Creation
Global Economic Conditions: 50%
Local Economic Conditions: 28%
Local Political Situation: 8%
Local Taxation Conditions: 10%
Global Political Situation: 4%
3. Expectations for North American Wealth Growth 2014
Increase: 67%
No Change: 32%
Decrease: 1%
4. Luxury Spending: 2014 vs. 2013
Increase: 36%
No Change: 57%
Decrease: 7%
5. Top Reasons for Making Investments of Passion
Personal Pleasure: 61%
Capital Growth: 22%
Status: 15%
6. Top Regions Looking at Art as an Investment
Latin America: 86%
Middle East: 58%
Russia/CIS: 57%
7. Philanthropic Giving 2014 vs. 2013
Increase: 15%
No Change: 81%
Decrease: 5%
8. Countries With the Most UHNWs in 2013
United States: 39,378
Japan: 16,540
Germany: 11,392
United Kingdom: 10,149
9. Countries Forecast to Have Greatest Precentage Gain in UHNWs by 2023
China: 80%
Singapore: 55%
Brazil: 44%
United States: 21%
10. Global Cities Ranked by Expected Precentage Growth in UHNWs by 2023
Ho Chi Minh City, Vietnam: 173%
Jakarta, Indonesia: 148%
Ordos, China: 141%
Mumbai: 126%
New Delhi: 118%


text:
Sixth Annual Burning River 100 to host USA 100 Mile Trail Championships
Provided by USATF
For the third year in a row, the Burning River 100 Mile Endurance Run will host the USA 100 Mile Trail Championships Saturday and Sunday, July 28-29, in Northeast Ohio.
Both champions return to defend their titles in Dave James and three-time Burning River 100 champion Connie Gardner. James won the race in 2011 in a time of 15:57:43 and Gardner's winning time was 19:01:39.
"I will always want to run the Burning River 100," Gardner said, who also claimed victories in the race in 2007 and 2009. "It's my hometown race in my own backyard. I love sharing and showing off our beautiful National Park with other runners from around the country. I'm hoping for a hot, humid summertime day."
"I have stepped up my training to levels equal to my 2009 form recently when I won three 100-mile races and ran most of the fastest 100-mile times in the world that year including my 13:06:52 in Cleveland," James said, who will be racing his second Burning River 100. "I have incorporated altitude training into my regime spending lots of time on trails above 10,000 feet in Flagstaff, Ariz."
The race, which starts in Willoughby Hills, Ohio, features a point-to-point course and ends in Cuyahoga Falls. The course runs along varying terrain that includes parts of three park systems – the Cleveland Metroparks, the Cuyahoga Valley National Park and the MetroParks serving Summit County. Approximately 350 runners are expected to participate in this year's Burning River 100.
"Once again we have a great field, and with so many runners there may be some surprise performances at this year's race," Race Director Joe Jurczyk said.
More information on the 2012 USA 100 Mile Trail Championships can be found at www.usatf.org.


text:
Monday, April 9, 2012
Matt Kemp named National League Player of the Week
From the Dodgers -
Los Angeles Dodgers center fielder Matt Kemp has been named National League Player of the Week for the period of April 4-8, 2012. The announcement was made earlier today on MLB Network.
In four games last week, Kemp batted .412 (7-for-17) while leading the Majors with six runs scored and tying for the Major League lead with eight RBI and 14 total bases. His two home runs and seven hits were both tied for third among National Leaguers, while his .824 slugging percentage ranked seventh. The Oklahoma native became the first Dodger to have three consecutive multi-hit games to begin a season since Adrian Beltre in 2000. Kemp collected hits in each of the first four games, extending his hitting streak to 16 games dating back to last season. His bat helped the Dodgers to a 3-0 start for the first time since 1999. The 27-year-old led the Dodgers out of the gate, going 2-for-5 with three RBI and a towering two-run homer en route to a 5-3 victory at San Diego's PETCO Park on Opening Day. On April 6th, 2011 N.L. All-Star went 2-for-4 with an RBI and two runs scored as the Dodgers took the second game of their four-game set at San Diego, 6-0. Kemp notched his third consecutive multi-hit effort on Saturday, going 2-for-4 with two RBI as the Dodgers topped San Diego, 6-5, in 11 innings. Kemp, a sixth round selection in the 2003 First-Year Player Draft, clubbed his second home run of the
season in Sunday's 8-4 loss to the Friars.
Other noteworthy performances last week included Kemp's Dodger teammates Chad Billingsley (1-0, 0.00 ERA, 8.1 IP, 11 SO, 1 BB, 3 H) and Andre Ethier (.267, 8 RBI, .733 SLG); Cincinnati's Jay Bruce (.273, 3 HR, 5 RBI, 3 R), who became the first player in Reds history to homer three times in the first three games of the season, along with Zack Cozart (.545, HR, 2 RBI, 4 R, 2 2B) and Johnny Cueto (1-0, 0.00 ERA, 7.0 IP, 4 SO); Carlos Beltran (.389, 2 HR, 3 RBI, 7 H), David Freese (.421, HR, 6 RBI) and Rafael Furcal (.526, 10 H, 3 R, 2 SB) of the St. Louis Cardinals; Milwaukee's Corey Hart (.444, 3 HR, 4 RBI, 1.556 SLG) and Zack Greinke (1-0, 0.00 ERA, 7.0 IP, 7 SO); Frank Francisco (0.00 ERA, 3 SV, 3.0 IP, 4 SO) and David Wright (.667, 6 H, HR, 3 RBI) of the New York Mets; Philadelphia's Roy Halladay (1-0, 0.00 ERA, 8.0 IP, 5 SO); San Diego's Clayton Richard (1-0, 0.00 ERA, 7.0 IP, 3 SO); and San Francisco's Pablo Sandoval (.417, HR, 4 RBI, .500 OBP).
In recognition of his National League Player of the Week Award, Matt Kemp will be awarded a watch courtesy of Game Time, the leader in licensed sports watches, available at MLB.com.
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When Lee Kuan Yew speaks, who listens? Presidents, prime ministers, chief executives, and all who care about global strategy.
Graham Allison and Robert Blackwill, two leading strategic thinkers, asked Lee Kuan Yew the toughest questions that matter most to thoughtful Americans weighing the challenges of the next quarter century. Drawing on their in-depth interviews with Lee as well as his voluminous writings and speeches, the authors extract the essence of his visionary thinking. The questions and answers that constitute the core of the book cover topics including the futures of China and the United States, U.S.-China relations, India, and globalization.
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Lee Kuan Yew does not retell the well-known story of Singapore's birth and growth to First World status. Nor do the authors interject their own thoughts or try to psychoanalyze Lee. Instead, they present his strategic insights in his own words. The result is textured and comprehensive, yet direct and succinct. Allison and Blackwill bring to bear their own experience as veteran government officials and senior scholars; their questions focus on essential policy choices as the U.S. pivots toward Asia.
Lee, the founding father of modern Singapore and its prime minister from 1959 to 1990, has honed his wisdom during more than a half century on the world stage. He has served as a mentor to every Chinese leader from Deng Xiaoping to Xi Jinping, and as a counselor to every U.S. president from Richard Nixon to Barack Obama. With his uniquely authoritative perspective on the geopolitics of East and West, Lee does not pull his punches. A few examples:
- Are China's leaders serious about displacing the U.S. as Asia's preeminent power in the foreseeable future? "Of course. Why not? Their reawakened sense of destiny is an overpowering force."
- Will China accept its place within the postwar order created by the United States? "No. It is China's intention to become the greatest power in the world—and to be accepted as China, not as an honorary member of the West."
- Will India match China's rise? "Not likely. India is not a real country. Instead, it is 32 separate nations that happen to be arrayed along the British rail line."
- On competition between East and West: "Westerners have abandoned an ethical basis for society, believing that all problems are solvable by a good government. . . . In the East, we start with self-reliance."
At the outset of the second Obama administration, Lee Kuan Yew is a timely and essential primer for every world leader and every reader who cares about the world.
A Council on Foreign Relations Book
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At the time of this writing Mac OS X had just been released as a Public Beta. Efforts are under way to bring MacPython to Mac OS X. The MacPython release 188.8.131.52.2c1 runs quite well within the ``Classic'' environment. A ``Carbon'' port of the MacPython code is being prepared for release, and several people have made a command line version available to the ``Darwin'' layer (which is accessible via Terminal.app).
See About this document... for information on suggesting changes.


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For most guitarists, multi-effect units are a mixed bag. While the benefits are obvious and the idea sound, a lot of affordable multi-effectors end up jack of all trades and master of none. More than a few readers have probably gone the affordable multi-effector unit thrilled that it could move from Dimebag Darrell tones to some crazy ring modulator with the flick of a switch—only to grow tired of the shrieking, icepick tones, cold tonality and inability to cut in a band setting.
But floorboard multi-effects units have come a long way since you found that cheap, $100 plastic box of bees beneath your Christmas tree. More processing power, ever-shrinking digital circuitry, and economical production make today's floor board multi effects units more compact, capable and affordable than ever. And the new generation of multi-effectors overflow with accurate vintage amps and effects models, simple and streamlined recording options and musical possibility.
We wanted to take a good look at just how far these devices have come in recent years, so we decided to have a go with three brand new floorboard multi-effectors—the Fender Mustang Floor, Boss GT-100 and ZOOM G5. We heard drastic improvements in modeling technology and encountered some digital limitations. But while there's room for evolution, each of these floorboard multi-effectors is a capable tool for guitarists that need a little bit of everything, whether on stage or in a recording situation.
Fender Mustang Floor Effects Processor
The Mustang amp series has been a huge success for Fender—combining amp and effects modeling into affordable do-it-all amplifiers. On top of that, they're pretty simple to operate, featuring an operating system that has a shallow learning curve that appeals to novice bedroom guitarists and studio players that like to call up sounds fast. With the Mustang Floor, they've condensed the entire package into a rugged metal floorboard with a simple, clean layout.
The Mustang Floor's firmware stores a total of 13 amp models, more than half of which are based on Fender amps including the '57 Deluxe, '65 Twin Reverb, Super-Sonic, '65 Deluxe Reverb, and others. The other models are emulations tending towards Marshall classics as well as the Mesa/Boogie Dual Rectifier and Peavey 6505. Amp modeling can also be bypassed, just in case you want to use the floorboard as an effects unit with your amp, without the amp modeling coloring the tone. Effects-wise, the selection is much broader—packing in 37 fully-customizable effects that cover overdrive, wah, compression, delay, chorus, flange, pitch shifting, ring modulation, reverb, and several other effect types. The floorboard's expression pedal can be assigned to control pretty much any amp or effect parameter on the fly, making it possible to do things like gradually increase an amp's preamp gain or midrange, deepen reverb depth, or push a delay's repeat count into self-oscillating craziness.
Like the other two floor processors in this roundup, the Mustang Floor is designed to be connected, routed and controlled in a variety of ways. Two XLR outs and two unbalanced 1/4" outs are available to hook up the unit to a mixing board or amp input, and a dedicated USB port for direct recording and patch updating is an option for players who want to record direct without crisscrossing cables. A MIDI control, a built-in effects loop, an auxiliary in, and 1/8" headphone out are also part of the package.
The first thing about the Mustang Floor that stands out is how well-built it feels. The weighty floorboard's metal enclosure feels sturdy in hand, and solid under foot moving through its switches. The expression pedal felt a little tight, but is adjustable via a screw on the side. After turning on the device, running a USB cable to my iMac, and connecting an Ibanez JS-1000 guitar, I fired up FUSE—Fender's software for creating and altering patches for the Mustang series—plugged in my headphones, and ran through the initial patches. Right off the bat, it's apparent that Mustang Floor has the same tone and nuances that typify the Mustang amps—full-bodied cleans, and overdrive tones that often need a lot of tweaking.
First off, the Mustang Floor's emulation of Fender's classics like the Twin Reverb are pretty nice, despite missing some of their signature sparkle on the highs. Still, they are very responsive and balanced on the whole. The Deluxe Reverb model in particular had a very striking midrange punch, through it could occasionally sound just a touch cold and processed in midrange-heavy applications—almost like hearing a great recorded tone played back from a mastered recording, which is actually a really nice thing if you're using the unit to record direct. Though if you're looking for the feel and skin-tingling snap of a great mid '60s Twin blaring behind you, the Mustang Floor routed through the house system isn't going to deliver all of the subtle nuances that an authentic rig would.
Great effects, excellent build.
Heavy overdrive and distortion can be overly bass-heavy. Some models are colder-sounding than others.
Playability/Ease of Use:
The unit's strength is the effects. And the Individual Stompbox mode that overrides the amp models so you can use the unit as a standalone effects unit is a really appealing function of the Mustang Floor for how good they are. The overdrives are smooth and highly tweakable, almost to the point where it's easy to apply too much of one control if you're not careful. Modulation effects are outstanding too—especially the excellent-sounding chorus and delay models, which add dimension when the tone is a bit flat.
The Mustang Floor is capable of crafting some seriously brutal distortion tones, in addition to sitting pretty well in early '70s classic rock scenarios. Getting the low end to behave itself can be the biggest hurdle. When I stuck with the Marshall-influenced models it's relatively easy to keep clarity intact. In fact, cranking the preamp gain and dropping the Ibanez's volume control yielded some of the best blues-rock overdrive tones in the unit, most of which that also had a really responsive midrange snarl. Heavier tones were harder to reign in though, mostly because the low end that the Mustang's software generates for models with copious overdrive borders on the colossal—especially with the American '90s and Metal 2000 models. And even though the patches containing these models were great starting points, a lot have sub tones that can overpower the signal. In thrashier applications I had to keep the Bass down to around 10 o'clock or lower, just to keep it tight underneath the mids and treble frequencies.
The Verdict
The Mustang Floor can make you look and sound like a pretty resourceful guitarist. And it's a great deal too. The tones often reveal a digital edge, but the convenience, superb effects, and rugged build merit high marks. If you're a fan of the Mustang modelers—or just need a solid, portable modeler for quick direct recording or stage use—it's more than worth a look.