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For the Love of Coffee: 5 Great Valentine's Day Gifts
There's no more romantic present than something shared—unless it's a cup of wonderful coffee brought to you in bed, that is. Assuming your favorite person already has that base covered, here are a few loving suggestions for the coffee person in your life.
Panama Finca La Valentina by PT's Coffee Roasting Co.
What says "I Love You" better than a rare, romantically named microlot of one of the world's most esteemed coffees? This crop of Panama Geisha beans, roasted by Kansas roasters PT's, hails from one of Panama's richest coffee-growing regions, the mile-high mountainsides of Boquete. Described with hints of white grape and honeysuckle with a high acidity, the small quantities and high quality of this coffee may result in a little bit of sticker shock (how much per ounce?)—but that just means you'll savor it together that much more lovingly.
Home Coffee Brewing Classes
We've finally acknowledged that manual coffee brewing at home is the proverbial jam, and most major cities have coffee companies willing to help you hone your skills. Give a romantic gift that keeps on giving (back to you) by sending your sweetie to a home brewing workshop, then demanding he or she make the coffee for as long as you can get away with it.
Shops like New York's Joe offer affordably priced pourover coffee workshops, as well as more advanced espresso and milk training, as do national companies like Counter Culture Coffee, and look for occasional classes at your local independent, too, like San Francisco Four Barrel Coffee. Be warned that your partner's new expertise may win them a few arguments about your pouring technique.
A Coffee-Themed Dinner
Whether or not you're near enough to Los Angeles to reserve a spot at a Valentine's Day dinner in Intelligentsia's Pasadena café, you can still take caffeinated inspiration if you plan to cook at home. From basic mole sauces to complex chilis to after-dinner liqueurs, you can move beyond the Valentine's cliché of plain-ol'-chocolate and keep your lover up all night. Due to sleeplessness, I mean.
Something for the Coffee Table
Are you and your beloved still brewing coffee at home in a crummy automatic drip machine? There are few things that express coffee's romance more visually than the iconic Chemex. The larger sizes (ranging from six cups and upwards) are perfect for brewing a couple of cups of clean, delicious coffee, morning through night. The six-cup one-piece Chemex with built-in handle makes pouring easy and...sure, we'll say it—kinda sexy.
Something for the Bedside Table
For many of us, our true love is coffee, but few have ever written such a love letter as Alon Halevy's new book, The Infinite Emotions of Coffee. Halevy, a senior research scientist at Google, has traveled the world romancing coffee while following the thread that connects the beguiling bean worldwide. Infinite Emotions documents its social implications through stories and pictures, told from a professionally-curious-person's angle, and a coffee lover's inspired perspective.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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Date : 11/08/2019
Time: 1:00 pm - 4:30 pm
What to wear
Appropriate protective clothing must be worn, i.e. race or 2 piece leathers, Kevlar Jeans, Gore-Tex or cordura fabric suits, helmet, gloves & boots.
A little bit of rain is usually fine but in the event of heavy prolonged downpours, strong winds or icy conditions, for your safety (and ours) we reserve the right to postpone the course (only if absolutely necessary). An alternative date will then be arranged.
Cost & Deposit
The total individual cost of the session is £125, with a deposit of £50 payable to secure your spot.
The rest of the balance can be paid by via PayPal or cash on the day.
Our ninja photographer will take some shots of you looking your best on one wheel.
Photos can be purchased on the day
See below for early bird 30% discount on photos
Availablity : 3
Bookings are closed for this session.

subset: commoncrawl


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Jeff Owens and Bob Pockrass Sporting News
SAT FEB 23 – DAYTONA BEACH, Fla. — At least 30 people were injured when car parts flew into the grandstands during a frightening Nationwide Series crash Saturday at Daytona International Speedway.
At least 12 cars were swept into a melee on the final lap, with rookie Kyle Larson's car lifting off the ground and slamming wheels-first into the front stretch grandstands near the flag stand. The front wheels and engine from Larson's car flew into the grandstands.
According to Speedway president Joie Chitwood, 14 fans were transported to local hospitals and 14 were treated at the infield medical center at the track. The Associated Press put the injury toll at 33.
Chitwood and NASCAR senior vice president Steve O'Donnell, who briefed the media on the accident Saturday evening, said they could not release information on the condition of the fans injured, referring the media to nearby Halifax Memorial Hospital.
Halifax Health spokesman Byron Cogdell said 12 people were transported to Halifax Health Medical Center in Daytona Beach and six others were taken to Halifax Health Medical Center of Port Orange. All were in stable condition, Cogdell said.
Lindsay Rew, a spokeswoman for Florida Hospital Memorial Medical Center, said its Daytona Beach hospital had one fan there who was in good condition. She said three others they had been expecting were diverted to another hospital.
No fatalities were reported at either hospital. Cogdell said two people taken to the Halifax in Daytona Beach arrived in critical condition, and one of those had life-threatening injuries, but both are considered stable.
Fans sitting near the crash described the accident as "surreal" and "shocking."
Ron Diehl Jr., who was sitting six rows up and about two sections from where Larson hit the fence, said debris from the accident was "raining down" but everyone near him was OK.
"It was surreal," Diehl said. "I was kind of in shock."
"As soon as he hit the catchfence, it kind of looked like the car exploded," Larry Spencer, a fan from Pennsylvania, said after returning from the hospital. "There was pieces of debris flying everywhere."
Chitwood and O'Donnell said that Sunday's Daytona 500 will run as scheduled.
"First and foremost, our thoughts and prayers are with our race fans," Chitwood said. "We responded appropriately according to our safety protocols and had emergency medical personnel at the incident immediately."
No drivers were injured in the accident and all 12 were treated and released from the infield medical center. Michael Annett was injured in an early accident and was transported to the Halifax hospital, where he was being held overnight.
The crash occurred about 50 yards from the start-finish line, where a wide section near a crossover gate was damaged.
Track workers were working feverishly Saturday night to repair the fencing.
"We are in the process of repairing this facility and will be ready to go racing tomorrow," Chitwood said.
Chitwood said the area of the grandstands where the accident occurred will be used Sunday during the Daytona 500.
"We don't anticipate moving any of our fans," Chitwood said. "We have our safety protocols in place, our security maintains a buffer that separates the fans from the fencing area. And with our fencing being repaired tonight to meet our safety protocols, we expect to go racing tomorrow with no changes."
Chitwood and O'Donnell said that both the track and NASCAR will conduct an investigation into the incident to see what changes may need to be made to fencing around Daytona and other tracks.
"We will review where the debris flew and what we need to do with that," Chitwood said.
"As with any of these incidents, we will conduct a thorough review and work closely with the tracks, learn what we can and see what we can apply in the future," O'Donnell said. "… We'll take the car and do that and we'll evaluate the fencing and see if there is anything we can learn."
Spencer tried to shield his 15-year-old brother from the debris. His brother suffered a gash to his left cheekbone, which needed three stitches.
Spencer was about four rows up in the Campbell grandstand right near where Larson hit the fence.
"As soon as I saw the pieces of debris go flying, I grabbed him and put my arms around him to shield him a little bit from any further injury."
Spencer, who said he is attending his sixth Daytona 500, saw the tire and its assembly come up into the stands and land two or three rows above him. He said the person hit by the tire appeared seriously injured.
He said he believes his brother was hit by a piece of the car. He said he took his brother to the restroom to get him cleaned up initially because so many other people were seriously injured.
"There was a lot of people up in those stands that were in worse shape than he was," Spencer said. "There were about two or three people that were laying and pretty much weren't moving.
"There were some people that were in rough shape."
Diehl, a fan from Maryland who has attended races at other tracks, was attending his first race at Daytona. He said his brother bought him the tickets as a Christmas gift and they were sitting together at the race.
"You saw the smoke and then we saw the impact and then parts started flying up in the air," Diehl said. "We saw a lot of the foam (from the car or the wall), some of the sheet metal … and I kind of froze and ducked my head."
The men have tickets in a different section for the Daytona 500. Diehl said he would sit in the same seats again.
"How often does this happen?" he said. "Hopefully everybody is all right."
Spencer, however, said he would not sit that low again. His tickets for the Daytona 500 are about 50 rows up on the backstretch.
"After seeing what I saw today with people just horrified and worried about their loved ones and the uncertainty, I certainly wouldn't sit there again," Spencer said. "It's as high as possible for me from now on."
Nationwide Insurance, the title sponsor of the Nationwide Series issued a statement Saturday night.
"Our thoughts and prayers are with the fans and their loved ones who were affected by today's incident," said Matt Jauchius, chief marketing officer for Nationwide. "We would like to commend NASCAR, Daytona International Speedway and the medical personnel involved for their quick response to the situation."
For more on this story go to:


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Sophiris Bio Announces 12 Month Follow-Up Data from Phase 2b TRIUMPH Clinical Trial of PRX302 in Patients with Benign Prostatic Hyperplasia
Oct 09, 2012, 07:00 ET
Single administration of PRX302 as a short outpatient procedure provided sustained benefit over 12 months
SAN DIEGO, CA and VANCOUVER, Oct. 9, 2012 /CNW/ - Sophiris Bio Inc. (TSX: SHS) today released top line data from the 12 month follow up of patients receiving PRX302 for the treatment of benign prostatic hyperplasia (BPH, or enlarged prostate) in a Phase 2b study (TRIUMPH). PRX302 produced a clinically significant improvement in the subjective symptom score (International Prostate Symptom Score, or IPSS) and the objective measure of mean peak urinary flow rate (Qmax) sustained over 12 months. As previously reported, the trial met the primary clinical endpoint of the study, which was to demonstrate the efficacy of PRX302 at 90 days post-treatment by a statistically significant improvement from baseline in IPSS when compared to placebo (vehicle only injection). Consistent with the results previously reported for this study, PRX302 continued to be well tolerated with no erectile function side effects during the 12 months following treatment.
PRX302 treatment resulted in approximately 8 to 9-point average reduction of IPSS that was sustained over 12 months. The IPSS is a patient self-administered questionnaire of lower urinary tract symptoms with a possible range of 0 to 35 points, with 0 being no symptoms and 35 being the high end of severe symptoms. This average improvement in IPSS was a clinically meaningful 2.8 to 4.1 point reduction over and above the IPSS improvement observed in the placebo group. In addition, PRX302 treatment resulted in a ~3 mL/sec average increase in Qmax, which was sustained over 12 months. Both IPSS and Qmax are validated clinical endpoints used for BPH product regulatory approvals.
PRX302 was well tolerated in this study with patients who had moderate to severe lower urinary tract symptoms due to BPH, about half of whom had previously taken oral medication for BPH. The side effect profile was favorable with most of the side effects attributed to the injection procedure itself and not related to drug toxicity.
"PRX302 is demonstrating potential as an alternative treatment to oral medications as well as surgical procedures," said Randall Woods, President and CEO of Sophiris Bio. "Patients commonly stop oral medications for lack of efficacy or side effects, or are non-compliant with taking daily pills. 'Minimally invasive' procedures that aim to remove excess tissue in the prostate require anesthesia and catheterization, which limit access for patients and add to cost. PRX302 has the potential to be safer than surgical procedures, more efficacious than oral medications, and with a sustained treatment effect for 12 months."
Woods added: "We expect to confirm these results in a pivotal study that closely resembles the design of this Phase 2b study and includes the same proven clinical endpoints used for prior regulatory approvals of drugs for BPH."
About BPH
Benign prostatic hyperplasia (BPH) is an enlarged prostate gland often resulting in a constricted or partially blocked urethra that can lead to pain, discomfort and other complications with urination. BPH occurs in almost all men as they age, with 50% of men over age 50 and 70% of men over age 70 complaining of symptoms. If untreated, it can lead to urinary problems such as:
- Trouble starting and stopping urination
- Frequent and irregular needs to urinate, particularly in the night while sleeping
- A weak urine stream
- Painful urination or urinary retention, leading to infections, stones or kidney damage
In the US, approximately 11 million men have been diagnosed with BPH. Five million of these patients are bothered enough by symptoms to seek treatment, such as daily pharmaceuticals, but these treatments often lack sustainable efficacy and are associated with undesirable side effects including sexual dysfunction. With current pharmaceutical treatments, symptoms will usually return if medication is discontinued. More aggressive treatment options include invasive surgical procedures that may be successful at treating BPH but may be accompanied by operative complications. Any type of prostate surgery can cause side effects, such as semen flowing backward into the bladder (retrograde ejaculation), loss of bladder control (incontinence) and impotence (erectile dysfunction).
About PRX302
PRX302 is designed to be a once-a-year treatment for the long-term relief of BPH symptoms without causing sexual dysfunction or sacrificing quality of life. PRX302 is precisely targeted to the prostate tissue constricting the urethra without damaging neighboring healthy tissue. It is delivered by a 1-3 minute injection completed during an office visit. PRX302 has been engineered to be activated only by the prostate specific antigen (PSA) enzyme that is produced in large amounts in the prostates of men with BPH. Once activated, PRX302 forms disruptive pores in the membranes of prostate cells, thus creating a highly targeted, localized and more convenient approach to eliminating prostate cells constricting the urethra.
About Sophiris
Sophiris Bio Inc. is a urology company developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH, or enlarged prostate), an unsatisfied market with large potential demand. PRX302, the company's lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is advised by world-leading urologists, backed by experienced investors, and led by a team that has achieved more than twenty drug approvals including drugs with annual sales in excess of $1 billion. For more information, please visit www.sophirisbio.com.
Certain statements included in this press release may be considered forward-looking, including statements about the potential for PRX302. Such statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on Sophiris' current beliefs as well as assumptions made by and information currently available to Sophiris and relate to, among other things, anticipated financial performance, business prospects, strategies, regulatory developments, market acceptance and future commitments. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties inherent in late stage drug development and risks relating to obtaining FDA and other regulatory approvals as well as risks identified by Sophiris in its public securities filings; actual events may differ materially from current expectations. Sophiris disclaims any intention or obligation to update or revise any forward-looking statements in this press release, whether as a result of new information, future events or otherwise.
SOURCE: Sophiris Bio, Inc.
For further information:
Lauren Glaser
Investor Relations
The Trout Group
[email protected]
James Beesley
Investor Relations
Sequoia Partners
[email protected]
Michael Moore
Investor Relations
TMX Equicom
[email protected]
Jason Spark
Media Relations
Canale Communications
[email protected]


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- 225020701
- Abstract Product Id
- 28781
- Concrete Product Id
- 106400
Forerunner 735XT GPS running watch bundle
Price incl. VAT
plus €16.35 for delivery to United States of America
Colour: black/grey
Availability in the stores
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Or do you want to proceed with the purchase of the standard model?
Coincidence is just not your thing, not during training, cycling or triathlon. All relevant data of your sports success should be available as detailed and easy as possible. In this case, the Forerunner 735XT by Garmin is the perfect training partner for you. It provides an exact analysis of your performance data to allow for continuous improvement. The Garmin lightweight comes in a traditional wrist watch shape and with soft and comfortable silicone wristbands.
Your heart on your wrist
Apart from the included RUN chest strap, this high-end watch with Garmin Elevate™ technology offers a 24/7 heart rate measurement at the wrist. In this way, you can also leave your chest strap at home and still call up statistics such as heart rate zones and heartbeats per minute in real time. Absolutely uncomplicated and as efficient as possible – just as you wish.
The Forerunner 735XT, equipped with GPS and GLONASS, also is a fitness tracker and stores your calories burned, your number of steps or your sleep data. When being too inactive, it reminds you to move with a vibration alert. The running & triathlon watch not only provides extensive multisport functions or extended performance analyses, such as running efficiency values (optional), recovery advice or cycling dynamics (optional). It also allows for a vast field of use, thanks to its integrated activity profiles, such as running (indoor/outdoor), cycling (indoor/outdoor) or swimming (swimming pool/open water).
For perfect availability of your performance data
Create customized training units and download them for free on Garmin Connect. Further online features are available when connecting the device with your smartphone. Thanks to automatic uploads on Garmin Connect, live tracking and smart notifications, the watch is ideally suited for you as an athlete. It allows you to securely store your smartphone, while also receiving all incoming information on the multisport watch. Moreover, free display designs, apps and data fields are available via Connect IQ.
With smart notifications, automatic uploads on Garmin Connect and live tracking, the Garmin Forerunner 735XT is the ultimate smartwatch for athletes. Store your mobile phone securely during long cycling, walking, or even swimming training units and receive all notifications on the multisport watch. The Garmin Forerunner 735XT can be customised with free display designs, apps and data fields by Connect IQ. Moreover, the Strava Suffer Score app is already preinstalled and provides you with a free 60-day trial version for Strava Premium.
Basic features:
• Lightweight and comfortable silicone straps
• Small display housing
• Compatible with Connect IQ: customisable display with data fields, display designs, widgets and apps
• Watch
• Date
• Alert
• Multisport functions for running, cycling, swimming, multisport, hiking, skiing, strength training, paddling sports and cardio
• Smartphone notifications (shows emails, text messages and other alerts when connected with your smartphone)
• Compass page
• Vibration alert
• Music features
• Audio announcement when connected with your smartphone
• Telephone search
• VIRB® operation
• With Varia connectivity fully linked with all Varia safety products
Running features:
• V02max estimate
• Lactate threshold, load value and performance level
• Competition forecast
• Recovery advice
• Training plans
• Running prediction
• Running efficiency
• Acceleration measurement (calculates the distance for indoor training, without requiring a running sensor)
• Personal records
Running and cycling features
• 24/7 heart rate measurement with Garmin Elevate™ technology (measurement at the wrist)
• Visual heart rate display
• Compatible with HRM Tri/Swim/Run chest strap (please also see Bundle, product code: 2250207 and 2250209)
• Compatible with speed and cadence sensor 2 kit (product code: 2290558))
• Complete running and cycling efficiency values provide data about your step length, balance of ground contact time, vertical ratio, power phase, Platform Centre Offset (Power Phase and Platform Center Offset optionally with Vector 2 powermeter, item no.: 2141480)
• Compatible with running sensor (optionally available with item no. 2098559)
• V02max and performance display when cycling: zones & time in zones (optional with power meter, see for example item no. 2141480)
• Compatible with Shimano Di2
• Compatible with Varia™ lighting / Radar / Varia Vision™ (see for example product code: 2155632)
• Virtual Partner: train against a virtual person
• Virtual Racer: compete against other activities
• Track function (you can transfer tracks and follow them)
• Auto Pause® (stop watch automatically stops, for example when you stop at traffic lights)
• Auto Lap: automatically records lap numbers
• Auto Scroll: automatic display of data fields during training
• Auto page turner
• Intensity minutes
• Extended training: create your own, target-oriented training units
• Pace alert (alert is triggered when you deviate from the preset pace)
• Time or distance alert (audible alert when you reach a preset value)
• Interval training (set training and break intervals)
• Heart rate based calory calculation
• Training Effect (effect of an activity on your aerobic fitness)
• Customizable display views
• Compatible with power measurement devices (display of performance data of compatible ANT+ power measurement devices of third suppliers)
Swimming features:
• Compatible with HRM Tri/Swim chest strap (see item no. 2173717 and 2173735)
• Swimming pool features (lanes, distance, pace, number of strokes/stroke number, calories burned)
• Identification of swimming style (e.g. crawling)
• Open water swimming features (distance, pace, number of strokes/stroke number, calories burned)
• Improved distance measuresment in open waters
• The Forerunner 735XT guides you through your swimming training
Fitness Tracker:
• Step counter
• Distance
• Calories burned
• Automatic goal (learns how active you are and allocates steps to a goal of the day)
• Inactivity bar (is shown on the device after inactive for a period of time; walk about for some minutres to reset the display)
• Sleep monitoring (monitors the total time of sleep as well as times of movement or quiet sleeping)
• Inactivity display and alert (vibration)
• Physiological measurements provide information about load value, performance level or lactate threshold (calculated from previous activities)
Garmin Connect:
• Compatible with Garmin Connect™ (online community for analysis, classification an exchange of data)
• Automatic synchronisation (automatic transmission of training units to the computer)
• Support of Connect IQ™: possibilities for customisation by downloading display designs, data fields, widgets and apps
• Physiological measurements
• Running/walking functions
• Competing against activities
• User-defined alerts
• Adjustable lap field
• UltraTrac™ mode to extend battery life: GPS reception is deactivated in certain time intervals and the acceleration sensor takes over the determination of distance and speed
• Display resolution: 215 x 180 pixels
• GPS/GLONASS receiver
• Interface: ANT+, Bluetooth Smart (only data transmission), USB
• Lithium-ion battery
• Battery life: approx. 11 days (watch mode), 14 hours (GPS), 24 hours (Ultra Trac™)
• Waterproof up to 5 ATM (50 m)
• Impact-resistant
• Dimensions: approx. 45 x 45 x 12 mm
• Display size: approx. 31,1 mm diameter
• Weight: approx. 40,2 g
In the box:
• Forerunner 735XT GPS watch
• HRM-Run chest strap
• Data/charging cradle
• Documentation
- Compatible with ANT+:
- Yes
- Bluetooth:
- Yes
- Yes
- Navigation:
- No
- Altimeter:
- No
- Smart Notifications:
- Yes
- 24/7 fitness tracker:
- Yes
- Cycling features:
- Yes
- Swimming features:
- Yes
- Heart rate measurement at the wrist:
- Yes
- Heart rate measurement with chest strap:
- Yes
- Manufacturer`s ref.:
- 010-01614-15
- 753759159290


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Following tonight's UFC 132 broadcast, UFC 133 will be the next pay-per-view event to get a "UFC Prelims" special on Spike TV.
Officials confirmed the broadcast plans with MMAjunkie.com (www.mmajunkie.com).
While the bouts haven't been set, likely options are light heavyweights Alexander Gustafsson (11-1 MMA, 3-1 UFC) vs. Vladimir Matyushenko (25-5 MMA, 7-3 UFC) and featherweights Chad Mendes (10-0 MMA, 1-0 UFC) vs. Rani Yahya (16-6 MMA, 1-0 UFC).
UFC 133 takes place Aug. 6 at Philadelphia's Wells Fargo Center. The PPV headliner pits Rashad Evans against fellow top light-heavyweight contender Phil Davis.
The UFC 133 "UFC Prelims" special will be Spike TV's seventh of 12 scheduled for 2011 (UFC 126, UFC 128, UFC 129, UFC 130, UFC 131 and UFC 132 also got them). ION Television also has aired specials when Spike TV hasn't, such as with UFC 127.
UFC 133's remaining preliminary-card bouts are expected to stream for free on Facebook.
The UFC first offered a PPV teaser broadcast for UFC 103 in 2009, when the UFC went head-to-head with a boxing PPV broadcast featuring Floyd Mayweather vs. Juan Manuel Marquez. The Spike TV specials proved effective enough at generating last-minute PPV buys that officials from the UFC and the organization's longtime cable partner decided to make them a regular offering.
The full UFC 133 card includes:
MAIN CARD (Pay-per-view)
- Phil Davis vs. Rashad Evans
- Rich Franklin vs. Antonio Rogerio Nogueira
- Yoshihiro Akiyama vs. Vitor Belfort
- Jorge Rivera vs. Alessio Sakara
- Rory MacDonald vs. Mike Pyle
(Spike TV)
- Alexander Gustafsson vs. Vladimir Matyushenko
- Chad Mendes vs. Rani Yahya
- Brian Ebersole vs. Dennis Hallman
- Ivan Menjivar vs. Nick Pace
- Johny Hendricks vs. Mike Pierce
- Mike Brown vs. Nam Phan
- Rafael "Sapo" Natal vs. Costantinos Phillippou*
* – Not officially announced
For the latest on UFC 133, stay to tuned to the UFC Rumors section of the site.
(Pictured: Chad Mendes)


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A professional wedding stylist will take the stress out of styling a wedding and create something that truly WOWs. To begin searching for your perfect stylist, have a rough idea of the wedding style and colour scheme you're after and your estimated styling budget. Then, read their customer reviews to ensure the stylist is a professional!Stylists Adelaide
Wedding Stylists Insights
There are 4 Adelaide Wedding Stylist suppliers from which to choose. Overall, they have an average rating of 5.0 out of 5. Couples usually enquire with 3 vendors in this category and book 12 months out from their wedding date, typically after Formal Wear and before Wedding Decorations. Engagement Venue suppliers range between $3,000 and $7,000, averaging at $5,000. Across Australia, the average cost is $5,110. Given Australian weddings typically cost $30,510, this means Australian couples spend 17% of their wedding budget on Wedding Stylist.
1 suppliers match your filters. Clear
We are passionate about helping you create and deliver a stress free wedding with memories that will last a lifetime.
No suppliers match your filters. Please try a different search


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Welcome to E-ZOIL
Performance. Pour it on.
We're all about performance. It's in our DNA. Our company was founded over 30 years ago with the sole purpose of providing owners and operators of vehicles and equipment with enhanced performance. We still live that philosophy today.
We invite you to explore our website to learn more about our performance-enhancing additives and cleaners.


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Sign in | Check Order Status | Holiday Shipping & Extended Returns
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The above time frames are not guaranteed, though in the vast majority of cases, are accurate. We will do our best to reach out in case of any delays.
*Please note that we are not responsible for delays due to customs. Figures for international shipping are our best estimates, but they will vary from country to country, and customs is often unpredictable.
This natural pinecone pendant features a Moldavite stone in the center.
This pendant measures approximately 2 long and includes a 32" brown faux leather cord and an information card about the pendant.
This is a natural product, which means that the actual shape, inner markings, and exact measurements of the cone and gems may vary slightly from photos.
Third Eye Pinecones are hand-crafted from the center of the worlds densest Pinecone, the Knobcone. The Knobcone Pine tree produces cones that stay closed for many years; when eventually exposed to fire, the cones open up, drop their seeds, and reproduce.
The pinecones used to make these pinecone pendants are sustainably wild-gathered high in the Santa Cruz Mountains. Once dried, aged, and cured, a single cross-section is cut from the heart of each cone. By cutting only a single cross-section per cone, the remainder of each Pinecone can be harvested and germinated for seed, therefore still contributing to the conservation of the unique species.
Each cross-section of pinecone is cleaned, sanded, polished, and designed, then sealed in resin. The resin seal protects the delicate cone itself, as well as the gemstone inlays. Pendants that are lighter in color are usually from a younger pinecone, while the darker pendants represent an older cone.
A few important details:
BillyTheTree.com. Family-owned since 2004.
Pandora is a registered trademark belonging to PANDORA. We are not affiliated, associated, authorized, endorsed by, or in any way officially connected with PANDORA.
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Suite 204, #157
Largo, FL 33771 USA
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Jeni Britton Bauer's Blueberry Cobbler
More than two pounds of fresh fruit are baked until bubbling to make this cobbler, found in Jeni's Splendid Ice Cream Desserts. Nine portions of shortcake batter are placed on top, to make a massive dessert that's messy and fun.
Why this recipe works:
- This recipe is super simple: toss the fruit in sugar, and use your food processor to make the dough. That's as labor-intensive as it gets.
- Often, fruit cobblers don't feel fruity enough. The use of blueberries makes gobs of thick juice that are sopped up by the shortcake dough, with enough left over to stain the ice cream you serve it with.
Excerpted from Jeni's Splendid Ice Cream Desserts by Jeni Britton Bauer (Artisan Books). Copyright (c) 2014. Photographs by Kelsey McClellan.
Read more: Bake the Book: Blueberry Cobbler
- Yield:makes 9 servings
- Active time: 15 minutes
- Total time:45 minutes
- 2 1/2 pounds blueberries
- 1 cup sugar
- 1/4 teaspoon fine sea salt
- Juice of 1 lemon
- 1/2 of dough for Sweet Cream Shortcakes (ingredients follow)
- Sweet Cream Shortcakes
- 3 cups self-rising flour, preferably White Lily
- 4 tablespoons cold unsalted butter
- 2 2/3 cups heavy cream
Make the dough: Put the flour and cold butter in a food processor and pulse 15 times. Add the cream and pulse until the dough comes together into a shaggy mess.
Turn the dough out onto a lightly floured surface and press it together. Fold the dough in half, then fold it over itself two or three times, just until it is no longer clumpy.
Make the cobbler: Butter an 8-by-8-inch baking pan. Combine the blueberries with the sugar, salt, and lemon juice in a medium bowl, tossing to coat.
Add to the prepared pan. Spoon the batter over the fruit, making 9 equal biscuits.
Preheat the oven to 375°F.
Bake the cobber for 35 minutes, until the tops of the biscuits are golden and the berries are bubbling. Remove from the oven and allow to cool slightly before serving.
This Recipe Appears InBake the Book: Blueberry Cobbler
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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Abortion Drones
The Abortion drone flies abortion pills from one country to women in another country. Using the different legislations and regulations it makes the reality of women in countries where abortion is restricted visible by creating access to the abortion pills.
Abortion drone Ireland, 2016
June 21 th, 2016. The Abortion Drone flew from the Republic of Ireland to Northern Ireland at Narrow Waters Castle. After the drone landed safely two women took the pills. At the same time Women on Waves employed a RC speedboat to send over more pills for the women. Making abortion illegal will… Read more »
First flight Abortion Drone, Poland 2015
The Abortion Drone was a success, women in Poland receive medical abortions. The drone departed from Germany and landed at the opposite side of the river in Slubice, Poland.
While the drones were crossing the German/Polish border , the German Police tried to intervene but the drone pilots… Read more »


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Equity futures are jumping this morning, below is a snapshot of DOW and S&P action over the weekend and overnight:
The dollar is down a huge amount, nearly a whole percent. That type of move is getting to the "unorganized" type of level. Caution though, as the bond market that was lower is now higher, signaling that not everyone and everything is heading in the same direction. Gold set another new high, touching 1,111, while oil is still in the $79 range.
Remember my article over the weekend where the IMF was talking down the dollar? Here's a news flash, the IMF needs to be disbanded! If you are an official outside of the U.S., I would strongly encourage you to not even talk to one of these criminals, much less do business or certainly not take a loan from them. They are the world's current mafia, their crimes are on a much higher level than anything ever seen in the history of man. They, their debt based money from nothing, and their manipulations need to be stopped.
Then the G20, a group entirely beholden to the same central bankers who run the IMF, come out with statements like this:
"Policy makers from the U.S., U.K., Japan and 17 nations said on Nov. 7 that it's too early to withdraw spending intended to revive growth. European Central Bank President Jean-Claude Trichet said before the G-20 meeting that "excessive volatility" in currency markets is damaging and a strong dollar is important for global economic stability.
"Markets don't need to be worried that these governments and central banks are suddenly going to take away all the stimulus measures," Stuart Bennett, a senior currency strategist at Calyon in London, said in an interview on Bloomberg Television. "Risk appetite should remain supported into the end of the year."
Makes me sick. Well, they will all go down together – the sooner the better. And there's that "strong dollar" comment again while I literally watch the dollar sink into the abyss.
But guess what… today's a phi mate turn date combined with a Bradley model turn. They are usually accurate to within a couple of days. There was no turn last week, and thus the odds are high for one this week, although there is very little economic data with which to produce large movements. Wednesday is Veterans Day (stock market open), and the only releases of note are International Trade, International Prices, and Consumer Sentiment all released on Friday.
The 1,070 level in the SPX is important to see if prices can remain over that range. 1,074 is the 61.8% retrace of what should have been the wave 1 decline. 1,090 is the next higher pivot, 1,107 follows that, 1,061 is the support pivot.
The DOW Industrials have now retraced more than 78.6% of their more shallow decline, but wave 2 being the "fool ya" wave can retrace up to 100%. If the DOW makes a new high, then it is likely that we are instead working on the final wave higher of wave B up.
Should be another interesting week, lip service, manipulations, bad data, and mass psychosis abound.
George Carlin Video: The Truth About Wall Street And Washington:


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Breaking news: Moretown Landfill will not be recertified
On Thursday, March 14, the Vermont Agency of Natural Resources (ANR) announced its decision to deny Moretown Landfill's recertification application. The Route 2 facility can continue to operate under its existing certification until April 15, 2013. After that, it will close.
The ANR denied Moretown Landfills recertification on two grounds: "the operator's failure to control odor and landfill gas emissions at the facility" and "the facility's contribution to violations of groundwater quality standards," the Agency explained in its decision announcement.
When the facility switched ownership from Interstate Waste Services to Advanced Disposal Services this past September, it invested over $450,000 in attempting to correct these problems, but ultimately the improvements were not enough. "The application provided by Moretown Landfill fails to demonstrate that proposed operational changes would result in the facility attaining compliance with the standards of the Solid Waste Management Rule," the ANR said.
This past December the ANR announced its "intent to deny" Moretown Landfill's recertification after the facility was cited for several environmental violations, but during a public comment period that followed, the ANR considered over 200 comments from Vermonters explaining how the landfill affects their livelihood.
While many of those comments came from Moretown residents, who either depend on the landfill as a source of revenue or suffer from its strong off-site odors, others came from out-of-towners, such as small business owners who worry how closing one of the state's two landfills will increase their already high overhead costs for trash removal and environmentalists urging the ANR to take a stance against negligent business practices.
The ANR addressed residents' concern about increased trash removal costs in its decision announcement: "Although there will only be one lined landfill in Vermont, it is important to note that the trash collection and disposal system in New England is regional, and includes other landfills in New Hampshire, New York and Massachusetts," the ANR said.
And the state has already begun investigating new landfill sites. "While there is significant capacity in the existing Vermont landfill, three other sites have also been through local and state permitting," the ANR said. "For a range of reasons the owners of those sites have not felt that it was worthwhile developing these permitted locations. The closure of Moretown may well make one of these other sites more viable."
The owners of Moretown Landfill have yet to respond to the ANR's decision, but the Moretown Select Board will discuss how the decision will affect the town at their next meeting on Monday, March 18.


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If the world really does get flooded like in Waterworld, energy supplies will be scarcer than ever. So we'll need this craft, the world's largest solar-powered boat, with 5,382 square feet of solar panels.
The ship, measuring 102 feet long and almost 50 feet wide, took 13 months to build in the German city of Kiel. It'll have its formal launching in April, and skipper Raphael Domjan hopes to sail it around the world in 2011. Images by AP. [Associated Press]


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As you must have realized by now, Zach and I have a pretty hardcore love affair with travel going on. I started traveling internationally at age 16, when I went to Australia and New Zealand through a student exchange program. That experience was all it took to get me hooked on exploring and wandering the globe. After that, I went on volunteer trips to the Bahamas and Kenya. If you remember all the way back to our "falling-in-love" story, you'll remember that I left Zach in Ohio when I went to serve as a Peace Corps Volunteer in Tanzania. After I got back and things got more serious between us, Zach caught my wanderlust disease hardcore. For the last few years, we've basically worked to travel, working overtime and saving all we could and then taking off on epic road trips and adventures. We've done multiple road trips through North America, and our seven-month Latin American Odyssey was the biggest adventure yet.
Needless to say, one of the wedding traditions we're most excited about is the HONEYMOON!!! There are just a few small obstacles to overcome first…
- We have no money.
- Zach has a real job now.
- We can't decide where to go!
Yep, the sad fact of the matter is that just paying for our broke-ass wedding is going to clean out most of our excess funds. Will it be totally worth it? I'm sure! Do I sometimes think we should just go to the courthouse and then book it to Thailand for a month? Hell yes!
There's also this whole "growing up and getting a real job" issue. It's something we've somehow managed to avoid…until now! Actually, I still don't have a "real job" but rather a seasonal internship AND four shifts a week at a bar/restaurant. Zach however, stumbled his way into an awesome job as a line cook in a 4-star restaurant, complete with salary and benefits and everything! It's a great new phase for him in a lot of ways, but unfortunately ample vacation days are not part of the deal. In the past, we always just up and left our jobs to travel and found new ones wherever we ended up when we got back. Not something we want to do anymore!
Suffice it to say, we will not be able to go on a big honeymoon anytime soon after the wedding, probably not anytime this year.
While it is kind of sad, we're going to make up for it in a couple ways.
#1. Vegas Friendy-moon!
A lot of our Ohio and east coast friends have never been out west at all. Because they're a fun-loving bunch, a lot of them are planning to tack on some Las Vegas adventures to their trip when they come out and see us get married. Although Zach and I aren't really "Vegas types", we decided to join, realizing we'd never, ever again get a chance to party on "The Strip" with so many of our best friends. Plus, I'm hoping the hotel will throw some perks our way if I tell them it's our "honeymoon."
#2. Real honeymoon in the future.
Despite our more settled, awesome life in San Diego, we can't go very long without traveling abroad. We're hoping to go somewhere, anywhere, for at least a few weeks as soon as we can swing it financially and job-wise. The problem is, we have no idea where to go! Top contenders…
Spain & Morocco
Thailand or Indonesia
Do you think planning two crazy nights in Vegas on the tail end of our wedding is a terrible idea? And where should we go for the big trip?


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Remember that story the other day about Aroldis Chapman's Pittsburgh hotel room being robbed while he was across the river at the Reds-Pirates game? Remember how it involved a woman in the room who was found bound by her hands and screaming shortly after the robbery occurred? Weird, right? Well, now it turns out that the woman, 26-year-old Claudia Manrique, who works as a stripper in Baltimore and Washington, D.C., has changed her story.
And guess what else? The cops have doubts about Manrique's account. Chapman says she may owe thousands of dollars to someone who helped her emigrate from her native Colombia. She has an ex-boyfriend who alleges she stole $2,000 from him just three months ago. What else? Oh, right: Manrique is currently "dating" Chapman, but the cops say she's married to a different guy.
The original story was that a man had knocked on the door of the room Manrique was sharing with Chapman, saying he worked for hotel maintenance. Once inside, the man demanded to steal items, tied up her hands using cloth napkins, and stole a variety of valuables.
Here's the Pittsburgh Post-Gazette:
One thing not taken was a Louis Vuitton bag containing more than $200,000 worth of Mr. Chapman's jewelry. Ms. Manrique said her attacker held her at gunpoint and demanded the bag of jewelry several times, ransacking the room when she refused to relinquish it. But, police reports note, she could not explain how the man knew the bag of jewelry was in the room in the first place.
When detectives confronted her about discrepancies in her story, she began to cry. A polygraph test showed she was not being truthful about the robbery, according to the report.
Ms. Manrique eventually changed her story, saying the robber first approached her at a CVS pharmacy and threatened to harm her friend in Silver Spring if she did not give him her room number. The man showed up a few hours later, and she let him in, fearing for her friend's safety.
So what was Chapman's take? According to the P-G, he "told police he began dating the Colombian native in April, and she would meet him in other cities where the Reds were playing." Here's more:
He later told detectives that Ms. Manrique had been receiving unwanted phone calls throughout her stay in Pittsburgh. He believed they were from a man in Maryland to whom she owed $9,000 on a $30,000 debt that allowed her to gain entry into the country, police reports say.
Mr. Chapman told police that Ms. Manrique "wasn't acting like herself" when she asked him if he could book her an earlier flight home.
Hey, it happens. So what's with the ex-boyfriend and the money? His name is Shahryar Kamouei, and there's a police report in Baltimore from March that says Manrique allegedly took $2,000 from him by gaining entry to his online bank account. The husband? That's who the cops say picked Manrique up at the police station Wednesday night. But who's he? According to Kamouei, Manrique's boyfriend before Chapman became Manrique's boyfriend, "She said she's only married to get a green card."


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Dungeon Fighter LIVE
XBLM – ME3: Earth multiplayer expansion hits 360 July 17, Oblivion and Fallout 3 sale starts today
Microsoft has updated its Xbox Live content schedule, and the releases kick off today with a sale on Fallout 3 and Oblivion content, Kinect PlayFit, and Portal 2 and Zumba Fitness Rush hit Games on Demand. Below the break you will also find a date for the free Mass Effect 3: Earth Multiplayer Expansion and […]
Dungeon Fighter LIVE headlines
Dungeon Fighter LIVE due on XBLA next week
Dungeon Fighter has finally secured a release date on Xbox Live Arcade: July 13. The hack-and-slash RPG hit Steam last week, but the console version is quite different; Dungeon Fighter Online was once touted as the Xbox 360's first freemium game, but in the end Nexon had to spin off a special, microtransaction-free version called […]
Nexon's Dungeon Fighter LIVE: Fall of Hendon Myre to release on XBL later this year
Nexon has released a promotional trailer for Dungeon Fighter LIVE: Fall of Hendon Myre, its Xbox Live version of Dungeon Fighter Online for PC. The video features scenes and illustrations of the original game's Slayer, Gunner, and Fighter characters, and is posted below. Microsoft Studios is set to publish the game, and it will be […]


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Will Scott of Search Influence has pointed out a new "feature" on a business's Places Page that is sure to infuriate more than one SMB. Right below the review section of the Places Page, Google has added a new section titled (with no little irony): Nearby Places You Might Like. This screen shot of the Places Page for a jeweler in Buffalo, Barbar Oliver & Co. Jewelry:
Since it was introduced, Google has promoted their Places Page as an alternative landing page for a business and it was highlighted as such during their Local Listing Ad test last year. There isn't an SMB in the universe that has invested in maintaining and highlighting their Places Page that wants nearby competitors listed on that very same page.
It is an interesting choice of upgrades to the Places page for Google to make. Clearly, from their point of view, they need to make the Places Page a beginning point to a users experience with Google not an ending point. As they have directeded more traffic internally to the Places Page instead of the list view in Maps, I am sure that they have found that users have no obvious place to go from there. The user interface to view more pages within Maps is not very noticable and most of the links on the page lead off site. Obviously, not a great strategy if selling more ads is the goal.
Google could have chosen, in the past, to highlight a business's Places Page in the main index but choose not to. Now, when a user does arrive at the page for a business there is a choice to visit competitors Place's Pages as well as other nearby businesses. In a strange interface convention, the link to a Nearby Places You Might (not) Like is selected it opens a new window in a very un-google like fashion.
Clearly, moving forward, Google is hoping to make the Places Page and elements on it more visible. They are also hoping to monetize this by enticing owners of the pages to either advertise or enhance their local listing. It seems to be an incredible bone head move if that is their plan to wave a red flag in these very same owners faces prior to that move.
This move will be perceived as "evil" regardless of their motivations and goals. One can only hope that it is a test of very limited duration and not a new, permanent part of the Places PageGoogle Places Adds Nearby Places You Might (not) Like by Mike Blumenthal


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Sentencing for Jackson Jr., wife set for August
A federal judge on Tuesday set Aug. 14 as the new sentencing date for former Illinois U.S. Rep. Jesse Jackson Jr. and his wife.
U.S. District Judge Amy Berman in Washington, D.C., scheduled the new hearing after Wednesday's original sentencing date was postponed. Berman previously noted that the rescheduling was done to "accommodate the court" and not at the request of the couple's attorney or prosecutors.
Jackson, the son of civil rights leader the Rev. Jesse Jackson Sr., pleaded guilty this year to spending $750,000 in campaign funds on personal items, including a gold-plated Rolex and mounted elk heads, among other things.
He faces a maximum five-year prison term. Under his plea agreement, Jackson must pay back the $750,000 and he'll be subject to a host of other financial penalties.
Jackson's wife, Sandi Jackson, is to be sentenced at the same hearing on a related conviction.
Last week, prosecutors filed a forfeiture motion listing the Jackson's two homes, which observers said could result in them losing one or both of them.
The Jacksons have two school-aged children, and the judge must decide whether to stagger their sentences so that they won't be in prison at the same time.


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Small Treasure Chest
By Neuchatel
This gold keepsake chest is filled with an exquisite treasure, Swiss Chocolates! From rich hot chocolate made from pure Swiss chocolate shavings to delicate chocolate coins, this treasure brings true delight.
All Swiss Chocolates
Neuchatel Chocolates imports all of their raw chocolate directly from Switzerland.
5th Generation Swiss Chef
Chef Albert Lauber is a fifth generation Swiss Chef, born , raised, and trained in Switzerland.
Time Tested Recipes
With over 40 years experience, Chef Albert has created a masterful collection of Swiss Chocolate confections.
Only the Best Ingredients
Chef Albert uses only the finest ingredients available to create his confections.


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- Home
- The Haves and the Have Nots
- The Haves and the Have Nots - Season 7 Episode 15
The Haves and the Have Nots - Season 7 Episode 15
Centers on the rich Cryer and Harrington families (the haves) and the poor Young family (the have nots) whose lives intertwine when Hanna Young begins working for the Cryers.
Actor: Renee Lawless , Jaclyn Betham , Crystal R. Fox , Tyler Lepley
Country: USA
Episode: 15/185 eps
Duration: 42 min
Quality: HD
Release: 2013
IMDb: 6
Season 1 - The Haves and the Have Nots
"Jim Cryer learns that his mistress has befriended his daughter; Candace blackmails Jim."
"Amanda has Wyatt and Jeffery assist her with the move into her new apartment while Hanna is set-up on a blind date by Benny."
"Benny prepares for his date by asking to borrow a car but is arrested and charged with drug possession after falling trap to someone's malicious intent. Amanda seduces her professor to raise her grade."
"It is revealed to Hanna that Benny happened to be behind the wheel of Candace's car. David reveals how he participated in the set-up. Katheryn ends up having a bond with Hanna regarding their issues."
"After all the issues going on around her, Amanda tries to commit suicide after an altercation with Candace sets her over the edge. Katheryn shames Candace directly after Jim reveals the affair."
"Katheryn tells everyone that she is leaving for vacation but that information turns out to be false. Veronica agrees to work on Benny's case. Wyatt is shocked when a previous girlfriend shows up. Jim receives the news that Amanda and Candace have moved into an apartment together."
"Jim and Candace end up in a verbal altercation. Amanda is in recovery while Katheryn might have to prepare for surgery. Wyatt receives another visitor from his past. After reviewing the case, Veronica questions Jim about some of the details. Amanda reveals a shocker to Candace, that she was raped."
"Information is discovered by a detective that links Benny and Tony. Veronica continues to work toward answers for Benny's case. Laura is kept away from Wyatt by Jeffery."
"Veronica collects enough evidence to send it off to David, which in turn exposes the conspiracy. Katheryn gets nervous when her secret almost goes public."
"After her secret is reveled, Katheryn tells everyone what she really knows about Jim's secret activities. Jeffery finally discloses his love for Wyatt."
"Jeffery tells his parents that he's gay. Hanna discloses that Tony is actually Benny's father. Candace informs Amanda that her parents are keeping her inheritance."
"Hanna waits at the hospital for news on Benny's condition; Candace tries to convince Amanda to stand up for herself."
"After a hit-and-run accident, Wyatt kills a little girl and Benny is on life support; Jim's campaign is in trouble; Amanda's on the verge of a breakdown; Hanna hears bad news about Benny."
"When Celine tries to destroy her accountability, Hanna clashes with Tony about keeping Benny on life support."
"Jeffrey realizes that Wyatt is responsible for Lizzie's death and Benny's condition."
"Candace asks Jim to move Benny to a private hospital."
"Jim tries to keep Wyatt out of jail; Tony serves Hanna with court papers."
"Candace represents Hanna in court; Amanda slips into the professors room while his family sleeps."
"Despite Wyatt's actions and Candace's threats, Jim readies his campaign announcement."
"The judge rules in Tony's favor; Hanna begs Tony to keep Benny on life support."
"Candace tries to blackmail Jim and David during their campaign event; Wyatt is arrested."
"As Katheryn is helping Hanna get out of jail, Wyatt is arrested for the hit-and-run of a little girl and Benny. Katheryn is devastated to learn that Hanna turned Wyatt in, but Hanna tells her that she will not sacrifice Benny for Wyatt, no matter how much Katheryn's helped him. Furious, Jim tells Hanna that he will not be accepting her apology when she discovers she's wrong about Wyatt being the hit-and-run driver. After some thought, though, Katheryn tells Jim that they should just let Wyatt pay for what he's done instead of protecting him.\n\nThen, after a dramatic day at the campaign office, David and Veronica continue to disagree about Jeffery's sexual orientation, and Jeffery still struggles with his own identity.\n\nElsewhere, Candace realizes that she is in a fight for her life when she is given an ultimatum by her captors.\n\nMeanwhile, Hanna is given hope at Mercy Hospital when Benny's new doctor tells her that her son is demonstrating slight brain activity."
"In the wake of Wyatt's arrest, Jim is confronted by the district attorney, Jennifer Sallison, and learns that Wyatt has confessed to the hit-and-run. To make matters worse for the Cryers, the DA vows to come after Jim next.\n\nAt Mercy Hospital, Hanna meets Darlene, a concerned nurse and former classmate of Benny's. Dr. Bailor also gives Hanna some hopeful news: He thinks Benny may not need the ventilator anymore.\n\nElsewhere, Jeffery confronts Veronica about Wyatt's arrest, but Veronica only continues to push her agenda by forcing Jeffery to go on a date with a young woman.\n\nMeanwhile, Candace is at the mercy of the Malones and is forced to come clean about not being pregnant to save herself from a forced abortion.\n\nLater, Amanda buys a gun from a pawnshop and asks the clerk some loaded questions about shooting professors.\n\nFinally, much to Maggie's surprise and chagrin, Jim holds a press conference and announces that he has been part of a cover-up."
"During a citywide press conference, Jim proclaims his son's innocence of the heinous double hit-and-run that killed a little girl and left Benny in critical condition. He declares that on the night in question, Wyatt did hit someone, a man named Donald (a paid prop), whom Jim introduces to the public. The gubernatorial candidate professes to have settled with Donald out of court, the actions of a loving, if misguided, father.\n\nMeanwhile, Hanna gets a frightful visit from Quincy as he searches for Candace. Later, at the hospital, she gets another unwelcome guest\u2014Tony has finally found where Benny is being treated and demands that he be taken off life support.\n\nElsewhere, Amanda continues to hint at murdering her parents, causing a worried Jeffery to reiterate his concerns to Katheryn. Across town, Jim gets Wyatt out of jail and brings him home.\n\nAnd, Candace is still tied up in the Malones' basement and must endure Rose's threats of a terrible fate."
"Hanna is overjoyed as Benny finally wakes up from his coma and makes astounding progress in recovery. He also reconnects with an old classmate who has been caring for him in the hospital.\n\nAfter Wyatt is released from jail, he contemplates his mistakes and goes to visit the grave of Lizzie, the little girl he killed, where he is recognized by the girl's mother as the hit-and-run driver.\n\nDavid continues to be supportive of Jeffery and attempts to understand his life by talking with Landon. However, David encounters another personal problem when Maggie oversteps her professional boundaries.\n\nMeanwhile, Quincy, the father of Candace's child, shows up at Candace and Amanda's apartment, and Amanda discovers that Candace's past is more of an enigma than she thought.\n\nElsewhere, Jim pays the still-captive Candace a visit and gives her a final chance to save her life."
"Benny prepares for his release from the hospital; Hanna plans to testify against Wyatt; Jim finds his fall guy; Quincy tries to get information about Candace from Amanda."
"After escaping her kidnappers, Candace asks Warlock for help; Jeffrey is seduced by Melissa."
"David's caught in a compromising position; Jim's plans to clear Wyatt's name causes tension; Candace panics."
"Amanda leaves the estate with Quincy and sends Katheryn into a panic; Candace hides out at Jeffery's place; Sallison pursues Wyatt and Jim."
"A news report claiming that another person is responsible for the hit-and-run saves Wyatt from jail. Katheryn berates Jim about his evil deeds. Hanna attempts to apologize to Jim for her hand in the tragedy, but he won't have it and orders her off his property; however, Katheryn has a tearful and beautiful reunion with her best friend, and offers Hanna her job back and to begin after Benny is settled in. Katheryn then tells Jim off about his attitude towards Hanna and orders him to keep Celine under control or else."
"Jim is confronted by Carlos, his illegitimate son with Celine. Katheryn's celebratory dinner party goes awry when Quincy, Candace's ex, shows up as Amanda's date. David and Veronica continue to battle over the fact that Jeffrey is gay. Candace seeks her revenge on Jim. Maggie makes another attempt to sleep with David."
Season 2 - The Haves and the Have Nots
"Hanna hosts a party for Benny; Jim is being held hostage; David resists the temptation to be intimate with Maggie."
"Hanna seeks information about Quincy's mother so she can get one step closer to finding her grandson's room."
"Wyatt gives Celine a taste of reality and he finds out a about his brother Carlos."
"Jim gives up and finally gives in to Candace's demands."
"Katheryn gets some devastating news."
"Everyone else is assembled at the Cryer mansion."
"Katheryn tells the story of how she first met Jim."
"Katheryn and David try to tell Veronica how wrong she is about Jeffery."
"Benny is convinced that Candace has changed her ways."
"Hanna comforts Jim after Amanda's death."
"David is angry at Veronica for telling Quincy to beat up Jeffrey."
"Benny searches for Quincy after he shows up at Hanna's home."
"Veronica starts a fire that destroys her mansion and almost claims David's life."
"Wyatt's confession to D.A. Sallison sparks controversy."
"Hanna finds out that Jim and Katheryn were holding Candace hostage."
"Hanna finds Benny in bed with Veronica; Melissa demands that Jeffrey's parents take care of her own."
"Candace shows Benny where she works."
"Quincy is hurt from the accident."
"Hanna is reunited with Q."
"Candace learns that Hanna is seeking custody of Q; and the Cryers and Harringtons try to convince the D.A. that Wyatt's taped confession is a misunderstanding."
"Candace buys property with the money she extorted from Jim; and Jim is interviewed on TV."
"While Jim is being interviewed by Dianna Winchill, a surprise guest arrives. Veronica tells Jim that she had planned Wyatt's attack in prison, leading Jim to attack her and later put a hit on her, Professor Cannon, and Prison Guard Terrell by calling three hitmen and ordering a \"bloodbath.\""
"Hanna grows suspicious of Benny's involvement with Veronica and how he acquired his new house; Quincy drives a car through Hanna's home in spite of revenge; Candace decides to let her guard down with Oscar."
"Hanna becomes devastated when she learns that Quincy set her house on fire; Maggie tries to talk David into running for Governor; Jeffrey gives Wyatt the necessary ammunition to take his parents down."
"Hanna and Benny force Candace to tell the truth about everything."
Season 3 - The Haves and the Have Nots
"Katheryn and Veronica are taken to the police station Candace and Jeffrey disagree on what to do with Quincy's body when interrupted by a knock on the door."
"Katheryn has had a lot of time for reflection while cooling her heels behind bars with Veronica. Candace and Jeffery get a visit from police because of a nosy neighbor."
"Katheryn is taken aback by the photo of Veronica in the arms of another man. Quincy wakes up and begs for Candace's help."
"Katheryn is unshaken by the DA's attempt to push. Candace's lies catch up with her."
"Benny agrees to help Candace hide evidence in Quincy's murder."
"Quincy Jr. passes out on Hanna after getting really sick and is taken to the hospital and placed in ICU."
"Maggie's lie to David could cause her to lose him forever; Katheryn gets out of jail but she can't find anyone to help Jim or Veronica."
"Candace interrogates the social worker; Hanna is steaking out at Cryer's mansion waiting for their return; Katheryn goes to visit David but little does she know that Wyatt is one step closer to getting his inheritance."
"Quita and Daylon break into Candace's house but are caught by Pearl, who calls her son Justin and his police squad to arrest them; Justin continues to harass Jeffery."
"Candace puts a plan into action to save herself and Benny from War's rage. Katheryn pleads with Hanna to not end their friendship. Veronica handles the hired assassin hiding in her house in an unexpected manner."
"Warlock has pushed up Candace's due date, so she goes to the bank to mortgage the houses and Benny's tow yard."
"Maggie visit's Veronica's home and gets the surprise of her life"
"Veronica treats David with much malice."
"After talking with Pearl, Hanna hopes to gain custody of Quincy Jr."
"Katheryn Cryer tries to process difficult news about one of her closest family members."
"Veronica and Jeffery go to visit Katheryn but Veronica pushes Jeffery to his limit."
"Jeffrey begins to implode so he calls Candace and Justin for help."
"Jennifer arrives at Katheryn's house to tell her that Wyatt is alive."
"Jim teams up with a former enemy in his scheme against Candace."
"Mitch breaks up the fight between David and Benny; David gets some shocking information about Mitch."
"The police are on the look out for Hanna so they question Candace and Benny."
"Benny learns the truth of how Candace financed his property. Candace finally tells him the truth about War and how she got the money, and what Mitch did but he doesn't believe her."
"Katheryn explodes when she is pushed to the limit. Benny finds out the truth about War by Mitch, who also reveals to Benny who he really is."
Season 4 - The Haves and the Have Nots
"Veronica tries to escape the Cryer Mansion. Jeffery is still trying to get a hold of Candace. Benny is still upset because of how Candace Mortgaged his house and the tow yard."
"Benny holds out hope that Candace will come through for the family."
"Veronica is still trying to escape Katheryn's mansion. Erica called Candace to give her an update on things with David."
"Veronica wants to meet with Candace and Jeffery. Jim helps Katheryn clean up a mess she has created."
"Veronica helps Candace and Jeffery out of a precarious predicament."
"Veronica pays Erica a visit Candace encounters Oscar again. Quit'a finds Wyatt's place and tells him that she's going to take his money."
"Veronica lets Jim know that if anything happens to her she has dirt on him. Hanna questions Benny and Candace about what they did to Quincy."
"Veronica planted a camera in those flowers she delivered to Erica. Hanna does all she can to keep the peace in her family."
"Veronica tells Justin to stay away from Jeffery. Candace makes Charles her latest Mark."
"Veronica is pushing Jeffery's buttons. Erica is caught sleeping with David by War."
"Veronica tries to seduce Benny. Warlock looks for Candace, Mitch returns from jail. Katheryn leaves Jim, Wyatt checks himself into rehab of his own volition."
"Veronica goes in a rage after Melissa attempts suicide in her bed. In the aftermath of the shootout it is revealed that Quincy Jr is dead."
"Veronica and Katheryn came face-to-face. Katheryn was able to be the friend that Hanna needed in comfort; Mama Rose inflict a bit of fear into Jim Cryer."
"Veronica intervened and proved her skills by representing Benny, Jim taunted Veronica, Hanna found herself at Katheryn's new rental home."
"Veronica threatens to reveal Officer Justin's secret and accuses him of sexually harassing Jeffrey. David and Jim find their sons. Charles reveals to Candace who he really is."
"Veronica visits Melissa at the hospital. Katheryn helps Hanna deal with Benny's situation. Wyatt gets released from the hospital. Charles beats Candace at her own game."
"Veronica tried to confront Erica and David on the elevator about their relationship. Landon tries to warn Charles about Candace. Jeffrey meets up with Landon."
"Veronica catches Officer Justin in Jeffrey's hotel room, and records Officer Justin. Jim is trying to find Warlock before Mamma Rose does."
"Veronica is confronted by Officer Justin. Candace starts to see Erica for who she truly is. Candace gets some devastating news."
"Veronica tells Landon to stay away her son. Jim is shocked to see that his house is on fire. Candace ask Mitch for a favor. Warlock gets caught in a deadly trap."
"Veronica makes Melissa clean her blood out of her bed. Jim and Katheryn implode with emotion. Jim confronts Katheryn, and begs her for retribution."
"Veronica gives Jeffrey and Officer Justin an ultimatum. Candace and Benny are at odds with each other. David tells Jeffrey to stay away from Veronica."
"Veronica does something that puts Officer Justin at rage. Candace struggles with sorrow and the death of Quincy Jr. Jim confronts Candace at The Artesian Hotel."
Season 5 - The Haves and the Have Nots
"Hanna is in mourning after a deadly shooting. Candace rejects Benny's pleas to help her. Veronica and Melissa find themselves in danger."
"Benny and Mitch risk their lives to save victims of a horrific auto accident. Justin professes his love and lust for Jeffery."
"David discovers Jeffrey's whereabouts. Hanna and Benny confront Candace."
"Hanna reveals a deep, dark secret; David calls Katheryn for help with Jeffrey."
"Justin tries to convince Jeffrey of his love; Candace and Benny fight to keep their relationship."
"Veronica returns home after a stay in the hospital; Candace and Jeffrey 's secret crime begins to catch up with them; Hanna meets a new man."
"Candace gets released from jail while David fights to get Jeffrey out of jail."
"Sarah and George make progress in prosecuting the Cryers; Veronica concocts a scheme against David."
"David fights to save his son Jeffery; Charles yearns to see Candace."
"Candace works on a new plan to recoup her money from the Cryers; Veronica is preoccupied by an all-consuming desire for revenge"
"Veronica lets it be known that she is the only queen in the kingdom; Candace reverts to old ways."
"Candace enacts her new money scheme like a boss."
"Wyatt once again finds himself in a life-threatening situation."
"Wyatt learns just how much trouble drugs can get one into."
"Benny wants to return the money to the Malone's but discovers it's not that simple."
"Katheryn learns that Wyatt's anger for her comes from childhood scars that are deep."
"Veronica and Candace scheme up a plan to hurt David."
"Officer Justin shows Jeffery just how serious he is about being with him."
"David is pushed by Veronica to a point that he didn't know he had."
"Charles learns that Landon may have ulterior motives."
"Benny's arrest forces Candace back to her old tricks to make some quick cash to leave town."
"Candace and Jim are up to their old tricks while people are caught in the crossfire of Veronica's wicked plots and intimidations."
"After being pushed to the limit, Veronica finally gets her revenge."
"David learns Erica's fate while being rushed to the hospital; the truth about Uncle Vinny's accident comes out, and the Malones now have a new target."
"An explosion in this small town sets more on fire than just a car. Who will survive?"
"While David is the hospital, Veronica gets a shock of her own."
"Veronica tries to convince RK to do some of her dirty work."
"Candace's plan begins to unravel as Benny discovers what she did to Hanna."
"Jim tries to save Wyatt from himself; Jeffrey deals with an uninvited guest."
"Candace comes face to face with Katheryn Cryer."
"The future president of the United States is back and chooses Candace."
"Jeffrey's scare with David brings him closer to Nurse Madison as the FBI gets one step closer to Veronica's wicked trail."
"Jim thinks he holds all the cards, but there's a ticking time bomb coming his way."
"Benny is severely rushed to the hospital following a shooting incident and Mitch reveals to Hanna about what happened with him. Katheryn attempts to mix business with pleasure. Veronica is taken to the hospital after falling off a stairwell railing and the FBI pays her a little visit."
"Secrets are revealed when everyone comes together at the hospital."
"Justin will stop at nothing to make sure Jeffrey is his."
"Veronica is simmering, and someone is going to get burned."
"Justin focuses on Jeffrey with laser-like intensity; Katheryn gets a taste of what it's like on the other side of the tracks."
"Wyatt is in jail; the Cryers secrets may make it out before he does."
"Jeffery comes to Justin's aid."
"Jeffery tries to handle the Justin situation amicably."
"Wyatt takes the witness stand intent on revenge."
"The Harringtons and the Cryers must join forces in order to save them all."
"A tattoo is worth a thousand words."
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Season 6 - The Haves and the Have Nots
"Details about Hanna's past are unraveled; Justin finally gets Jeffery to himself; Candace and Charles have a very special dinner."
"Some dinners end with dessert, but not at Justin's house."
"Madison intercepts an ominous call at the hospital."
"Veronica faces off with Officer Justin while Scott builds his case against Candace."
"No one is safe from the danger looming in the city of Savannah, Ga."
"Candace plans to turn over a new leaf."
"David's blunder has deadly consequences; Candace loses something precious to her."
"Veronica and Wyatt retaliate against their enemies."
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Season 7 - The Haves and the Have Nots
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Season 8 - The Haves and the Have Nots
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text:
Active ingredient
- galantamine hydrobromide
Legal Category
POM: Prescription only medicine
POM: Prescription only medicine
This information is intended for use by health professionals
AdministrationGalsya XL prolonged-release capsules should be administered once daily in the morning, preferably with food. The capsules should be swallowed whole together with some liquid. The capsules must not be chewed or crushed.For patients with difficulty swallowing: The capsules may be emptied and the tablet core(s) swallowed whole together with some liquid. The capsule contents (tablet cores) must not be chewed or crushed.Ensure adequate fluid intake during treatment (see section 4.8). Before start of treatmentThe diagnosis of probable Alzheimer type of dementia should be adequately confirmed according to current clinical guidelines (see section 4.4).
Starting doseThe recommended starting dose is 8 mg/day for 4 weeks.
Maintenance dose• The tolerance and dosing of galantamine should be reassessed on a regular basis, preferably within three months after start of treatment. Thereafter, the clinical benefit of galantamine and the patient's tolerance of treatment should be reassessed on a regular basis according to current clinical guidelines. Maintenance treatment can be continued for as long as therapeutic benefit is favourable and the patient tolerates treatment with galantamine. Discontinuation of galantamine should be considered when evidence of a therapeutic effect is no longer present or if the patient does not tolerate treatment.• The initial maintenance dose is 16 mg/day and patients should be maintained on 16 mg/day for at least 4 weeks.• An increase to the maintenance dose of 24 mg/day should be considered on an individual basis after appropriate assessment including evaluation of clinical benefit and tolerability.• In individual patients not showing an increased response or not tolerating 24 mg/day, a dose reduction to 16 mg/day should be considered.• There is no rebound effect after abrupt discontinuation of treatment (e.g. in preparation for surgery).Switching to Galsya XL prolonged-release capsules from galantamine tablets or galantamine oral solutionIt is recommended that the same total daily dose of galantamine is administered to patients. Patients switching to the once-daily regimen should take their last dose of galantamine tablets or oral solution in the evening and start Galsya XL prolonged- release capsules once daily the following morning.
Paediatric populationThere is no relevant use of galantamine in the paediatric population.
Hepatic and renal impairmentGalantamine plasma levels may be increased in patients with moderate to severe hepatic or renal impairment. In patients with moderately impaired hepatic function, based on pharmacokinetic modelling, it is recommended that dosing should begin with 8 mg prolonged-release capsule once every other day, preferably taken in the morning, for one week. Thereafter, patients should proceed with 8 mg once daily for four weeks. In these patients, daily doses should not exceed 16 mg. In patients with severe hepatic impairment (Child- Pugh score greater than 9), the use of galantamine is contraindicated (see section 4.3). No dosage adjustment is required for patients with mild hepatic impairment.For patients with a creatinine clearance greater than 9 ml/min no dosage adjustment is required. In patients with severe renal impairment (creatinine clearance less than 9 ml/min), the use of galantamine is contraindicated (see section 4.3).
Concomitant treatmentIn patients treated with potent CYP2D6 or CYP3A4 inhibitors, dose reductions can be considered (see section 4.5).
Cardiac disordersBecause of their pharmacological action, cholinomimetics may have vagotonic effects on heart rate (e.g. bradycardia). The potential for this action may be particularly important to patients with sick sinus syndrome or other supraventricular cardiac conduction disturbances or in those who use medicinal products that significantly reduce heart rate concomitantly, such as digoxin and beta-blockers or for patients with an uncorrected electrolyte disturbance (e.g. hyperkalaemia, hypokalaemia).Caution should therefore be exercised when administering galantamine to patients with cardiovascular diseases, e.g. immediate post-myocardial infarction period, new-onset atrial fibrillation, second degree heart block or greater, unstable angina pectoris or congestive heart failure, especially NYHA group III IV.In a pooled analysis of placebo-controlled studies in patients with Alzheimer dementia treated with galantamine an increased incidence of certain cardiovascular adverse events were observed (see section 4.8).
Gastrointestinal disordersPatients at increased risk of developing peptic ulcers, e.g. those with a history of ulcer disease or those predisposed to these conditions, including those receiving concurrent non-steroidal anti-inflammatory drugs (NSAIDs), should be monitored for symptoms. The use of galantamine is not recommended in patients with gastro-intestinal obstruction or recovering from gastro-intestinal surgery.
Nervous system disordersAlthough cholinomimetics are believed to have some potential to cause seizures, seizure activity may also be a manifestation of Alzheimer's disease. In rare cases an increase in cholinergic tone may worsen Parkinsonian symptoms.In a pooled analysis of placebo-controlled studies in patients with Alzheimer's dementia treated with galantamine cerebrovascular events were uncommonly observed (see section 4.8). This should be considered when administering galantamine to patients with cerebrovascular disease.
Respiratory, thoracic and mediastinal disordersCholinomimetics should be prescribed with care for patients with a history of severe asthma or obstructive pulmonary disease or active pulmonary infections (e.g. pneumonia).
Renal and urinary disordersThe use of galantamine is not recommended in patients with urinary outflow obstruction or recovering from bladder surgery.
Surgical and medical proceduresGalantamine, as a cholinomimetic is likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia, especially in cases of pseudocholinesterase deficiency.
Pharmacodynamic interactionsBecause of its mechanism of action, galantamine should not be given concomitantly with other cholinomimetics (such as ambenonium, donepezil, neostigmine, pyridostigmine, rivastigmine or systemically administered pilocarpine). Galantamine has the potential to antagonise the effect of anticholinergic medication. Should anticholinergic medication such as atropine be abruptly stopped there is a potential risk that galantamine's effect could be exacerbated. As expected with cholinomimetics, a pharmacodynamic interaction is possible with medicinal products that significantly reduce the heart rate such as digoxin, beta-blockers, certain calcium-channel blocking agents and amiodarone. Caution should be taken with medicinal products that have potential to cause torsades de pointes. In such cases an ECG should be considered.Galantamine, as a cholinomimetic, is likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia, especially in cases of pseudocholinesterase deficiency.
Pharmacokinetic interactionsMultiple metabolic pathways and renal excretion are involved in the elimination of galantamine. The possibility of clinically relevant interactions is low. However, the occurrence of significant interactions may be clinically relevant in individual cases.Concomitant administration with food slows the absorption rate of galantamine but does not affect the extent of absorption. It is recommended that Galsya XL be taken with food in order to minimise cholinergic side effects.Other medicinal products affecting the metabolism of galantamine Formal drug interaction studies showed an increase in galantamine bioavailability of about 40% during co-administration of paroxetine (a potent CYP2D6 inhibitor) and of 30% and 12% during co-treatment with ketoconazole and erythromycin (both CYP3A4 inhibitors). Therefore, during initiation of treatment with potent inhibitors of CYP2D6 (e.g. quinidine, paroxetine or fluoxetine) or CYP3A4 (e.g. ketoconazole or ritonavir) patients may experience an increased incidence of cholinergic adverse reactions, predominantly nausea and vomiting. Under these circumstances, based on tolerability, a reduction of the galantamine maintenance dose can be considered (see section 4.2).Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, at a dose of 10 mg once a day for 2 days followed by 10 mg twice a day for 12 days, had no effect on the pharmacokinetics of galantamine 16 mg prolonged- release capsules taken once a day at steady state.Effect of galantamine on the metabolism of other medicinal products Therapeutic doses of galantamine 24 mg/day had no effect on the kinetics of digoxin, although pharmacodynamic interactions may occur (see also pharmacodynamic interactions).Therapeutic doses of galantamine 24 mg/day had no effect on the kinetics and prothrombin time of warfarin.
PregnancyFor galantamine no clinical data on exposed pregnancies are available. Studies in animals have shown reproductive toxicity (see section 5.3). Caution should be exercised when prescribing to pregnant women.
Breast-feedingIt is not known whether galantamine is excreted in human breast milk and there are no studies in lactating women. Therefore, women on galantamine should not breast-feed.
|System organ class
|ADR frequency
|Very common
|Immune system disorders
|Metabolism and nutrition disorders
|Decreased appetite, anorexia
|Psychiatric disorders
|Hallucination, depression
|Hallucination visual, hallucination auditory
|Nervous system disorders
|Syncope, dizziness, tremor, headache, somnolence, lethargy
|Paraesthesia, dysguesia, hypersomnia, Seizures*
|Eye disorders
|Blurred vision
|Ear and labyrinth disorders
|Cardiac disorders
|Supraventricular extrasystoles, atrioventricular block first degree, sinus bradycardia, palpitations
|Vascular disorders
|Hypotension flushing
|Gastrointestinal disorders
|Vomiting. nausea
|Abdominal pain, abdominal pain upper, diarrhoea, dyspepsia, stomach discomfort, abdominal discomfort
|Hepatobiliary disorders
|Skin and subcutaneous tissue disorders
|Musculoskeletal and connective tissue disorders
|Muscle spasms
|Muscular weakness
|General disorders and administration site conditions
|Fatigue, asthenia, malaise
|Weight decreased
|Hepatic enzyme increased
|Injury, poisoning and procedural complications
Reporting of suspected adverse reactionsReporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via: Yellow Card SchemeWebsite: www.mhra.gov.uk/yellowcard
SymptomsSigns and symptoms of significant overdosing of galantamine are predicted to be similar to those of overdosing of other cholinomimetics. These effects generally involve the central nervous system, the parasympathetic nervous system, and the neuromuscular junction. In addition to muscle weakness or fasciculations, some or all of the signs of a cholinergic crisis may develop: severe nausea, vomiting, gastro-intestinal cramping, salivation, lacrimation, urination, defecation, sweating, bradycardia, hypotension, collapse and convulsions. Increasing muscle weakness together with tracheal hypersecretions and bronchospasm, may lead to vital airway compromise.There have been post-marketing reports of torsade de pointes, QT prolongation, bradycardia ventricular tachycardia and brief loss of consciousness in association with inadvertent overdoses of galantamine. In one case where the dose was known, eight galantamine 4 mg tablets (32 mg total) were ingested on a single day.Two additional cases of accidental ingestion of 32 mg (nausea, vomiting, and dry mouth; nausea, vomiting, and substernal chest pain) and one of 40 mg (vomiting) resulted in brief hospitalisations for observation with full recovery. One patient, who was prescribed 24 mg/day and had a history of hallucinations over the previous two years, mistakenly received 24 mg twice daily for 34 days and developed hallucinations requiring hospitalisation. Another patient, who was prescribed 16 mg/day of oral solution, inadvertently ingested 160 mg (40 ml) and experienced sweating, vomiting, bradycardia, and near- syncope one hour later, which necessitated hospital treatment. His symptoms resolved within 24 hours.
TreatmentAs in any case of overdose, general supportive measures should be used. In severe cases, anticholinergics such as atropine can be used as a general antidote for cholinomimetics. An initial dose of 0.5 to 1.0 mg i.v. is recommended, with subsequent doses based on the clinical response.Because strategies for the management of overdose are continually evolving, it is advisable to contact a poison control centre to determine the latest recommendations for the management of an overdose.
Clinical studiesGalantamine was originally developed in the form of immediate-release tablets for twice-daily administration. The dosages of galantamine effective in these placebo-controlled clinical trials with a duration of 5 to 6 months were 16, 24 and 32 mg/day. Of these doses 16 and 24 mg/day were determined to have the best benefit/risk relationship and are the recommended maintenance doses.The efficacy of galantamine has been shown using outcome measures which evaluate the three major symptom complexes of the disease and a global scale: the ADAS-cog/11 (a performance based measure of cognition), DAD and ADCS-ADL-Inventory (measurements of basic and instrumental Activities of Daily Living), the Neuropsychiatric Inventory (a scale that measures behavioural disturbances) and the CIBIC-plus (a global assessment by an independent physician based on a clinical interview with the patient and caregiver).Composite Responder Analysis Based on at Least 4 Points Improvement in ADAS-cog/11 Compared to Baseline and CIBIC-plus Unchanged + Improved (1-4), and DAD/ADL Score Unchanged + Improved. See Table below.
|At least 4 points improvement from baseline in ADAS-cog/11 and CIBIC-plus Unchanged + Improved
|Change in DAD ≥ 0 GAL-USA-1 and GAL-INT-1 (Month 6)
|Change in ADCS/ADL-inventory ≥ 0 GAL-USA-10 (Month 5)
|n(%) of responder
|Comparison with placebo
|n(%) of responder
|Comparison with placebo
|Diff (95% CI)
|Diff (95% CI)
|Classical ITT*
|21 (5.0)
|18 (6.6)
|Gal 16 mg/d
|39 (14.7)
|8.1 (3.13)
|Gal 24 mg/d
|60 (14.2)
|9.2 (5.13)
|40 (15.3)
|8.7 (3.14)
|Traditional LOCF#
|23 (5.6)
|17 (6.5)
|Gal 16 mg/d
|36 (14.2)
|7.7 (2.13)
|Gal 24 mg/d
|58 (14.5)
|8.9 (5.13)
|40 (15.8)
|9.3 (4.15)
|* ITT: Intent To Treat + CMH test to difference from placebo # LOCF: Last Observation Carried Forward
|Placebo (n=245)
|GAL-IR# (n=225)
|GAL-PR* (n=238)
|p-value (GAL-PR* vs. placebo)
|Composite response: n (%)
|20 (8.2)
|43 (19.1)
|38 (16.0)
|# Immediate-release tablets * Prolonged-release capsules
General characteristics of galantamine
AbsorptionThe absolute bioavailability of galantamine is high, 88.5 ± 5.4%. Galantamine prolonged-release capsules are bioequivalent to the twice-daily immediate- release tablets with respect to AUC24h and Cmin. The Cmax value is reached after 4.4 hours and is about 24% lower than that of the tablet. Food has no significant effect on AUC of the prolonged-release capsules. Cmax was increased by about 12% and tmax increased by about 30 minutes when the capsule was given after food. However, these changes are unlikely to be clinically significant.
DistributionThe mean volume of distribution is 175 l. Plasma protein binding is low, 18%.
BiotransformationUp to 75% of galantamine dosed is eliminated via metabolism. In vitro studies indicate that CYP2D6 is involved in the formation of O-desmethylgalantamine and CYP3A4 is involved in the formation of N-oxide-galantamine. The levels of excretion of total radioactivity in urine and faeces were not different between poor and extensive CYP2D6 metabolisers. In plasma from poor and extensive metabolisers, unchanged galantamine and its glucuronide accounted for most of the sample radioactivity. None of the active metabolites of galantamine (norgalantamine, O-desmethylgalantamine and O-desmethyl- norgalantamine) could be detected in their unconjugated form in plasma from poor and extensive metabolisers after single dosing. Norgalantamine was detectable in plasma from patients after multiple dosing, but did not represent more than 10% of the galantamine levels. In vitro studies indicated that the inhibition potential of galantamine with respect to the major forms of human cytochrome P450 is very low.
EliminationGalantamine plasma concentration declines bi-exponentially, with a terminal half-life around 8-10 hours in healthy subjects. Typical oral clearance in the target population is about 200 ml/min with intersubject variability of 30% as derived from the population analysis of immediate-release tablets. Seven days after a single oral dose of 4 mg 3H-galantamine, 90-97% of the radioactivity is recovered in urine and 2.2-6.3% in faeces. After i.v. infusion and oral administration, 18-22% of the dose was excreted as unchanged galantamine in the urine in 24 hours, with a renal clearance of 68.4 ± 22.0 ml/min, which represents 20-25% of the total plasma clearance.
Linearity/non-linearityGalantamine pharmacokinetics of prolonged-release capsules are dose proportional within the studied dose range of 8 mg to 24 mg once-daily in elderly and young age groups.
Characteristics in patientsData from clinical trials in patients indicate that the plasma concentrations of galantamine in patients with Alzheimer's disease are 30% to 40% higher than in healthy young subjects primarily due to the advanced age and reduced kidney function. Based upon the population pharmacokinetic analysis, clearance in female subjects is 20% lower as compared to males. The galantamine clearance in poor metabolisers of CYP2D6 is about 25% lower than in extensive metabolisers, but no bimodality in the population is observed. Therefore, the metabolic status of the patient is not considered to be of clinical relevance in the overall population.The pharmacokinetics of galantamine in subjects with mild hepatic impairment (Child-Pugh score of 5 to 6) were comparable to those in healthy subjects. In patients with moderate hepatic impairment (Child-Pugh score of 7 to 9), AUC and half-life of galantamine were increased by about 30% (see section 4.2).Elimination of galantamine decreases with decreasing creatinine clearance as observed in a study with renaly impaired subjects. Compared to Alzheimer patients, peak and trough plasma concentrations are not increased in patients with a creatinine clearance ≥ 9 ml/min. Therefore, no increase in adverse events is expected and no dosage adjustments are needed (see section 4.2).
Pharmacokinetic/pharmacodynamic relationshipNo apparent correlation between average plasma concentrations and efficacy parameters (i.e., change in ADAS-cog/11 and CIBIC-plus at month 6) were observed in the large Phase III trials with a dose-regimen of 12 and 16 mg twice-daily.Plasma concentrations in patients experiencing syncope were within the same range as in the other patients at the same dose.The occurrence of nausea is shown to correlate with higher peak plasma concentrations (see section 4.5).
Prolonged-release tablet core:Sodium laurilsulfateAmmonio methacrylate copolymer (type B) HypromelloseCarbomers Hydroxypropylcellulose Magnesium stearateTalc
Capsule shell:GelatinTitanium dioxide (E171) Iron oxide, red (E172) Iron oxide, yellow (E172) Black ink:ShellacPropylene glycolAmmonia solution, concentrated Iron oxide, black (E172) Potassium hydroxide
No. 1 Church Road, Richmond upon Thames, Surrey, TW9 2QE, UK
+44(0) 20 3751 1888
+44(0)20 3751 1889