Bone metastasis is a common metastasis site such as lung cancer, prostate cancer, and other malignant tumors. The occurrence of bone metastases of lung cancer is often accompanied by bone loss, fracture, and other skeletal-related events (SREs) caused by tumor proliferation and osteoclast activation. Furthermore, along with the differentiation and maturation of osteoclasts in the bone microenvironment, it will further promote the occurrence and development of bone metastasis. Protein drugs are one of the most promising therapeutic pharmaceuticals, but in vivo delivery of protein therapeutics still confronts great challenges. In order to more effectively conquer bone metastases and alleviate SREs, herein, we constructed biomineralized metal-organic framework (MOF) nanoparticles carrying protein toxins with both bone-seeking and CD44-receptor-targeting abilities. More importantly, through combination with Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) antibody, in vivo results demonstrated that these two protein agents not only enhanced the detraction effects of protein toxin agents as ribosome-inactivating protein (RIP) on bone metastatic tumor cells but also exhibited synergistic intervention of the crosstalk between bone cells and tumor cells and reduced SREs such as bone loss. Collectively, we expect that this strategy can provide an effective and safe option in regulating bone-tumor microenvironments to overcome bone metastasis and SREs.


Abstract : The design of an underwater device to measure sea noise to depths of about 12,000 feet is required. It is desired that the recording equipment be contained in a body to be launched from ships that sink to a prescribed depth, stay there during the recording time interval and rise to the surface after recording. The body sends a homing signal and is recovered by the ship. This memorandum presents the results of an analysis of design requirements for the proposed hydrodynamic body. The analysis indicates that a simple and relatively light body can be designed to meet the requirements. The proposed body has a double hull with the inner hull containing the instruments being resistant to the hydrostatic pressures. The outer hull is used for hydrodynamic considerations and to provide the driving and release weights.


,A persistent problem in journalism has been the inability of historians to pinpoint with assurance the origin of the Associated Press, America's first successful press association. Newspapers have their volume one, number one to record their birth, and if the file copies are lost, perhaps the letters or a diary of some midwife editor or reporter who was associated with the originating effort may offer a clue. The Associated Press, however, did not print an end product itself, it was a side venture for its editor-originaton, and it apparently went through several stages of development and revision in its first few years. Moreover, for a number of years after AP was organized, its copy bore no credit lines or logotypes in the columns of participating newspapers. A signed partnership agreement forming a Harbor News Association has come to light, however, and may at last confirm the date of AP's formal


The "San Cristobal" design was used in seedlings of Pinus greggii growing in nursery conditions, to analyze the direct effects and the interadion effects of nitrogen (N), phosphorus (P) and potassium (K) in their growth and development in this cC'ndition. The data obtained from the development of seedlings were used in rowth functions and represented in surface responses. In addition, the height, d,ameter, and shoot, root and total biomass were used to construct morphological indexes which are helpful to estimate seedling quality.


Equivalent to Euro Ⅲ emissions regulation,strict demands for engine management system(EMS) and three way catalysts(TWC) are presented,as which has own characteristics on durability testing cycles.This paper introduces that EMS coupled with A/F control self-learning strategy,and a new-type three-way catalysts with a high-performance Ce0.55Zr0.35Y0.05La0.05O2 and a high surface area La/Al2O3.Test results revealed that Ce0.55Zr0.35Y0.05La0.05O2 solid solution has superior textual and oxygen storage properties,and La/Al2O3 has superior textual properties.The results from the vehicle show that the new-type catalyst can easily meet China stage Ⅲ emission requirements.


A class of topological algebras, which we call it a fundamental locally multiplicative one, has already been introduced and the exponential map has been defined before on complete metrizable fundamental locally multiplicative topological algebras. Here, in this note we prove the main identification about this map. Mathematics Subject Classification: Primary 46H; Secondary 46A


This SIG proposes starting a discussion on the CHI platform about the issues pertinent to the design of digital payments and digitization of financial services. Although there has been a lot of discussion in HCI around domains such as health and education, the domain of financial HCI is still nascent. The purpose of this SIG is to engage researchers and the broader community at CHI in the discussion and debate around digital payments for the next billion users. We propose creating a live working document starting before the SIG which continues to develop during and after the SIG. This live document will enable to engage with a wider audience of researchers, and industry practitioners outlining processes, methods, and tools that HCI4D researchers have created to work with emergent users to develop ICT interventions.


One of the ways to increase the maneuverability of the wheeled vehicles of the National Guard of Ukraine is to use a four-axle wheeled chassis with two turntables, which will allow the machine to turn with the smallest radius, move crab, sideways and turn around its own vertical axis. The creation of such a chassis is associated with a large amount of various experiments and tests of the finished sample. The development of computer technology and technologies has led to the creation of software applications for computer (simulation) modeling, which allow research and study of the properties of technical objects and systems under different conditions. The article developed a digital model of the chassis of a four-axle machine with two turntables and identified its features. For modeling, a powerful package of solid modeling Autodesk Inventor was chosen, which provides a comprehensive flexible set of tools for 3D design, visualization, instrumentation, analysis and calculations. When building a general 3D model of the chassis, the main features of the layout of parts and assemblies of this wheeled vehicle were taken into account. The forced rotation of the wheels and the rotation of the platforms were modeled by entering the value of a single parameter or setting using a graph. Depending on the needs of the experiment, graphs were set for displacements, speed or acceleration. In the course of a visual experiment, a simulation of the maneuvering of a four-axle vehicle was carried out for three options: turning the chassis to move in the opposite direction; changing the direction of movement through the turn of the chassis is a difficult maneuver; turning the chassis for sideways movement. The analysis of virtual studies showed that the control of the front, rear or both turntables is a promising way to increase the maneuverability of wheeled vehicles. In addition, the created computer prototype allows you to determine the main characteristics of the future product, carry out analysis, upgrade and necessary modification, set the desired trajectory of movement, including when passing through obstacles.


The book is an original practice of writing the history of literature.Through literature noumenon the authors rearranged the Chinese literature of the 20th century.The exploration into the aesthetic features of those art works and the history of stylistics show the authors' enterprising spirit and special pursuit.


A study was made of extraction of lanthanide(III) (from lanthanum to holmium) nitrates by solutions of trialkylmethylammonium di(2-ethylhexyl) phosphate in toluene at T=298.15 K and pH 2. The extraction isotherms were analyzed assuming formation of two different extraction complexes (R 4 N) 3 [Ln(NO 3 ) 3 A 3 ] and (R 4 N) 2 [Ln(NO 3 ) 3 A 2 ] in the organic phase. The extraction constants calculated from the experimental results increase in passing from lanthanum to europium and then decrease to holmium.


The objective of the experiment was to evaluate discarded ewes slaughtered at different physiological stages and terminated in feedlot for yields of carcass and cuts and the percentage of each non carcass component. Twenty-one Santa Ines ewes were used, with average age of six years old, distributed into the following treatments: EL = ewes that had remained in lactation for 60 days with their respective lambs until slaughtering; EWL = ewes that remained in lactation for 60 days with their respective lambs and a further 30 days approximately without lambs to recover lost of body weight during suckling, and were subsequently slaughtered; and ENC = ewes that remained in feedlot for 60 days and did not deliver during the year. The results obtained in this research showed that ewes that remained in feedlot for 60 days and did not deliver during the year presented higher hot (45.00) and cold (44.73%) carcass yields, compared to ewes that had remained in lactation for 60 days with their respective lambs until slaughtering (40.80 and 40.66%). Carcass cut (leg, loin, shoulderblade, ribs and neck) yields were similar among all ewes slaughtered in the different physiological conditions. Non carcass component yields were similar among the ewes slaughtered in different physiological stages, except for the liver, blood, udder and internal fat values.


A 68-year-old woman underwent pharmacologic stress testing for evaluation of chest pain. Adenosine,140 ug/kg/minute was administered intravenously. The patient's heart rate rose from 83 to 115 beats/minute (sinus rhythm) and her blood pressure decreased from 150/90 mmHg to 120/90-mmHg during the infusion. During the second minute of the stress test, the patient reported nausea, headache, and vomiting. The symptoms worsened progressively, necessitating termination of adenosine administration after 4 minutes and 45 seconds. The headache resolved after adenosine administration was discontinued. After the test, the patient continued to have recurrent nausea and vertigo, precipitated'by headturning to the right and she complained of general weakness. There was diplopia on leftward gaze. Slightly slower fine motor movement was found in the left


I argue that the study of ancient criticism is unduly narrow unless it combines an awareness of the materiality of culture—of the forms in which literary texts were produced, circulated, stored up, and accessed—with an appreciation for how strongly performance traditions could shape the reception and valuation of such texts. To illustrate, I analyze the 25th chapter of Aristotle's Poetics to show that the theory behind "Problems and Solutions" was less significant culturally than the many-formed game of using poets in ethical debate. Also included is a brief overview of work since Vol. 1 of the Cambridge History of Literary Criticism (edited by George Kennedy in 1989) that fruitfully confronts the idea of the work of art as text with the reality of the work of art as performance.


Campaign organisation Just A Ball Game? (JBG?) and Bradford City LGBT+ Fan Group call on FIFA to take firm and further action on the homophobic, biphobic and transphobic insults directed at players during international football matches.


Recently, many Markov chain Monte Carlo methods have been developed with deterministic reversible transform proposals inspired by the Hamiltonian Monte Carlo method. The deterministic transform is relatively easy to reconcile with the local information (gradient etc.) of the target distribution. However, as the ergodic theory suggests, these deterministic proposal methods seem to be incompatible with robustness and lead to poor convergence, especially in the case of target distributions with heavy tails. On the other hand, the Markov kernel using the Haar measure is relatively robust since it learns global information about the target distribution introducing global parameters. However, it requires a density preserving condition, and many deterministic proposals break this condition. In this paper, we carefully select deterministic transforms that preserve the structure and create a Markov kernel, the Weave-Metropolis kernel, using the deterministic transforms. By combining with the Haar measure, we also introduce the Haar-Weave-Metropolis kernel. In this way, the Markov kernel can employ the local information of the target distribution using the deterministic proposal, and thanks to the Haar measure, it can employ the global information of the target distribution. Finally, we show through numerical experiments that the performance of the proposed method is superior to other methods in terms of effective sample size and mean square jump distance per second.


Objective: To evaluate the efficacy and side effect of combined chemotherapy with Delisheng in the treatment of old aged lung cancer.Methods: Fifty-seven patients with aged lung cancer were divided randomly into control group including 27 patients and therapy group including 30patients.Patients of therapy group was treated by Delisheng and EP;control group only by EP.Results: In therapy group effective rate was 46.7% ;control group was 40.0% ,significant difference was not observed between the two groups(P0.05).For life quality and side effect,significant difference were observed between the two groups(P0.05).Conclusion: The combination of Delisheng and EP is effective in improving the quaity of life and side effect for aged patient with lung cancer.


Purpose – The purpose of this paper is to propose a conceptual framework of customer expectation management and a reference model of service experience design which are regarded as the basic foundation to model the processes of service experience design for service operation strategies simulating and testing by employing a system dynamics approach.Design/methodology/approach – System dynamics is the key approach which includes causal loop diagrams and stock and flow diagrams used to build the reference model of experience design. Simulations of the processes of service experience design have also been implemented by Vensim®.Findings – It is found that the proposed reference model involving customer expectation management can successfully capture the key elements of the service experience design within service operation strategies. The system dynamics approach can effectively enable a macro viewpoint of service experience design for service operation strategies and policies.Practical implications – With th...


Coherent states achieve the Holevo capacity of a pure-loss channel when paired with an optimal measurement, but a physical realization of this measurement scheme is as of yet unknown, and it is also likely to be of high complexity. In this paper, we focus on the photon-counting measurement and study the photon and dimensional efficiencies attainable with modulations over classical- and nonclassical-state alphabets. We analyze two binary-modulation architectures that improve upon the dimensional versus photon efficiency tradeoff achievable with the state-of-the-art coherent-state on-off keying modulation. We show that at high photon efficiency these architectures achieve an efficiency tradeoff that differs from the best possible tradeoff--determined by the Holevo capacity--by only a constant factor. The first architecture we analyze is a coherent-state transmitter that relies on feedback from the receiver to control the transmitted energy. The second architecture uses a single-photon number-state source.


A bound on the rate of convergence and sufficient conditions for the convergence of moments are obtained for the sequence of waiting times in the GI/G/1 queue when the traffic intensity is at the critical value ρ = 1.


Regardless of their label (learning disabled, behaviorally disordered, speecManguage impaired, etc.), children who have deficits or excesses in their social behavior present an enormous challenge to classroom teachers. Their behaviors interfere with the presentation of instruction, disrupt classroom routines, and set the occasion for negative interpersonal interactions. An even greater, long-term difficulty is the persistence of social behavior problems; these children often fail to outgrow their interpersonal handicaps (Michelson & Mannarino, 1986; Loeber, 1985; Robins, 1978; Wahler & Dumas, 1986). We must teach many children how to become more socially competent using the same strategies that we use to teach academic skills (Cullinan & Epstein, 1985; Rathjen, 1984): instruction, practice, and feedback. Just as with academic skills, practitioners who wish to teach social skills must choose the most efficient strategy (or strategies) from a wide array of practices. This article describes some promising practices in teaching social skills. These practices are empirically valid and will promote persistent and generalizable skills.


Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their alpha subunits prevented the increase in GTPase activity induced by substance P, compound 48/80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of alpha subunits of G proteins by mimicking the agonist-liganded receptors.


We consider a multi-satellite maneuvering problem, in which multiple satellites in the same elliptical orbit must coordinate to reach distinct target sets at a future time while avoiding collisions, and also minimize fuel consumption. We cast the maneuvering problem as a stochastic optimal control problem, where the stochastic disturbances account for unmodeled phenomena that corrupt the Clohessy-Wiltshire-Hill relative space vehicle dynamics. We propose a convex optimization based approach that can efficiently construct provably safe, sub-optimal controllers by solving a collection of quadratic programs. Our approach reformulates the control problem as a difference-of-convex program, in which collision avoidance constraints are enforced using the quantile function of a chi distribution. In numerical experiments, our approach is two orders of magnitude faster than particle control, which only provides approximate collision avoidance guarantees.


A total of 2850 triple systems possessing planar distribution of identical bodies with no angular momentum have been computer-evolved. The results in the configuration space of the initial conditions are discussed and the existence of finite regions where quantities change relatively smoothly is demonstrated. The minima and maxima of the running size of the triple systems are analyzed and it is shown that, as expected, they are concentrated between approximately 0.5 and 1.5 of the mean harmonic separation between the particles.


Tau and α-synuclein are major players in neurodegenerative diseases, but their physiological role, particularly in dendrites, is poorly understood. Here we show that, surprisingly, lack of tau protein induces the development of a more elaborate dendritic arbor of hippocampal pyramidal cells in organotypic tissue. Using high-speed volumetric lattice light-sheet microscopy and single particle tracking, we found a more directional KIF1A-mediated transport in dendrites of Tau KO cells. Increased transport processivity correlated with longer and straighter dendritic microtubules as revealed by three-dimensional super-resolution microscopy of cultured hippocampal neurons. Unbiased mass spectrometric analysis of tissue showed highly increased expression of α-synuclein in Tau KO hippocampi. Overexpression of α-synuclein mimicked the transport characteristics observed in Tau KO cells. Our data indicate that tau and α-synuclein shape microtubule-dependent transport in neuronal dendrites, thereby promoting dendritic arborization during maturation. Furthermore, the data demonstrate that transport efficiency and length and straightness of microtubules are correlated.


In this paper, the conversion of tigecycline, a first-in-class glycylcycline antibiotic, into a fluorescent degradation product with quantitative purposes by UV irradiation and its fluorimetric determination are reported for the first time through the presentation of a spectroscopic method for the determination of this compound. A multicommutated flow-assembly employing three-way solenoid valves is used for the analysis, with the entire procedure being computer-controlled. The degradation product is measured at excitation and emission wavelengths of 333 and 453 nm, respectively, obtaining 33 µg L−1 as the detection limit, a linear dynamic range between 0.1–2 µg mL−1, and a R.S.D. of 2.8% (n = 10).


This article concerns the stability and stabilisation of a linear system with both state and input delays. First, the combination of an augmented Lyapunov functional and the free-weighting-matrix technique yields a new delay-independent stability criterion that includes the widely used one as a special case. This criterion is then extended to a new delay-dependent stability criterion by employing an integral inequality. Based on that, a stabilisation approach to design a state feedback controller is presented that requires no parameter tuning, as is needed with some existing methods. Finally, numerical examples illustrate that the method is effective and is an improvement over existing ones.


During the electrokinetic remediation(ER)of heavy metal polluted soil,the soil closer to anode has lower pH value and higher redox potential.Either low pH or high redox is helpful to release heavy metal from soil particles and therefore to accelerate the remediation.So,the "approaching anodes" technique was developed as a simple way to shorten the distance between the anode and cathode and consequently to enhance the remediation.In this technique,a series of anodes were placed in the soil successively.The anode farthest from the cathode was chosen as working anode at the beginning of remediation.After the soil in the vicinity of the anode was cleaned,the working anode was switched to the next anode nearer to the cathode.During the whole ER process,the working anode was switched in order to reduce the distance between anode with cathode gradually.Synthetic Cd contaminated soils was used to test the feasibility of the approaching anodes technique.The results showed that the energy consumption per unit volume was significantly reduced in ER process with approaching anodes,which was only about 56% of that with single anode while achieving the same effect.Besides,Cd migration velocity was largely increased and the whole operating time was accordingly saved.The enrichment velocity of Cd in places of 5,10,15 and 20 cm was about 1.50,2.44,3.72 and 2.00 times to that with single anode respectively.Thus,this process showed great priority and was quite promising in practical application.


According to the "Implicit grammatical rule deficit hypothesis" (Crago & Gopnik, 1994) adapted by Fee (1995) to phonology, Consonant Vowel (CV) structure is universal and complex syllable structures are reduced to CV. Syllabic structures and their simplification processes were analysed in a group of children with SLI (N=5) and compared with those found in two control groups, one matched by age (N=5), and the other by MLU-w (N=5). The children with SLI were slower to acquire syllabic structures than the Age Controls, and maintained simplification processes that were not seen in their age-matched counterparts.
Language Level Controls and the children with SLI presented differences in the first acquired structure, the CV. However, syllabic simplifications do not appear to be unique to the SLI; even though simplifications persist for longer in these subjects than in Age Controls, their prevalence is similar to that found
in the MLU-w controls. Our results do not support Fee's hypothesis.


The rising cost of energy has compelled most countries to seek methods of economizing on their energy consumption, typically by the use of more energy-efficient generation processes. The combined gas and steam turbine process is one example of a step in this direction. This article reviews an investigation that has, among other things, demonstrated the feasibility of increasing the electricity produced by a back-pressure power generation plant by 30 to 40 percent for the same thermal load by combining an industrial back-pressure power generation plant with a gas turbine. In the long term this should prove highly attractive, since the electricity produced by back-pressure generation requires only half as much fuel input as electricity generated in a condensing steam power station.


In Florida, this could lead to a number of problems. Projections show temperature increases of 3-4 degrees Fahrenheit year-round. Higher temperatures and more frequent heat waves could increase heat-related deaths and illnesses from insect-borne diseases like malaria, West Nile virus, and dengue fever. Warmer conditions would also increase the frequency algal blooms along the coast, damaging fish populations with adverse impacts both on human health and on local economies. Sea levels could rise 18-20 inches along the Florida coast with substantial impacts on human populations and ecologically sensitive areas including the Everglades and Big Cypress Swamp. Coastal beaches and wetlands would be threatened, and drinking water supplies would be exposed to increased salt water contamination Coastal areas could also face increased damages during hurricanes and other severe weather events as higher sea levels increase the danger form storm surges. Higher temperatures would also increase the already high rate of evaporation in the state, putting increased stress on water systems that already face increasing and competing demands from drinking water needs, agriculture, and ecosystems.


One of the research hotspot in strategic missile is to develop a multifunctional and lightweight composite launcher, which has a certain bearing capacity and anti-fragment penetration capability. On this basis, this paper designs the launcher's wall by using carbon fiber reinforced epoxy resin composite double cone structure (CFREPDCS) as sandwich core layer. Due to obtain the high-speed impact energy-absorption and failure characteristic of the CFREPDCS, the quasi-static collapse experiment and the LS-DYNA finite element simulation were used. The experimental results and the scanning electron microscope show that the failure mode of the carbon fiber reinforced epoxy resin composite (CFREP) circular tube is progressive failure, which includes matrix fragmentation and fiber fracture. The CFREP circular tube with larger wall thickness has higher specific energy-absorption (SEA), approximately 58.6 J/g. The coupled relationship between SEA and mid-diameter height shows that the maximum SEA occurs while mid-diameter height reaches 8 mm. On the other hand, the change of the mid-diameter height also reflects the influence of loading direction on SEA. This study provides the significant guide to design and manufacture of sandwich carbon fiber composite launcher.


The Effects of Green Tea on the Body Weight and Histoarchitecture of the Testis of Adult Male Sprague dawley Rats. Int J Clin Exp Physiol. 2018;5(3):141-4. ABSTRACT Background and Aim: Green tea is an aromatic beverage derived from the cured leaves of Camellia sinensis . It is a potent herb which serves various therapeutic purposes. This study was carried out to determine the effect of the administration of various concentration of green tea extract (GTE) on the histoarchitecture of the testis of Sprague dawley adult male rat. Methods: 20 animals were divided into four groups, comprising of 5 animals each. The control group was given distilled water while the treated groups were given 2ml/kg, 4ml/kg and 6ml/kg of aqueous extract of green tea respectively for 26 days. At the end of the administration on the 27th day, in accordance with IACUC regulation, the animals were euthanized following the administration of AGTE after which they were dissected and the testes were excised for tissue processing. Results: There was a progressive decrease in weight of the treated animals corresponding to the increase in the concentration of green tea. The histological analysis showed that the GTE at 2ml/kg did not disrupt the histoarchitecture of the testicular tissue; however, there was mild to moderate degeneration at 4ml/kg and 6ml/kg respectively and this histoarchitectural distortions of the testis by of GTE may take a direct or indirect path; thus, may induce testicular dysfunction. The Feulgen stain intensity was more in the control and group 1, when compared to group 2 and 3, which is a pointer to DNA ma- terial loss in testicular tissues at higher doses. Conclusion: Lower dose of GTE may seem beneficial; however higher doses pose more harm in a short period, when compared to the benefit of the lower dose on the body and testicular tissue. However, there is the need for further investigation on the role and mechanism of action of GTE on testicular cellular and tissue dysfunction and consequence on reproduction.


Solar cells Photo Voltaic Pile, which are key tools in energy conversion, are used. Most of the materials used as semiconductors in solar cells are used. Energy absorption of light energy (photons) by a semiconductor and the production of electron hole pairs and then removing the load carrier is. Understanding junction solar cells with p - n, notions of how to increase the efficiency of these cells, the amount of energy used to produce cost and offers them. Analytical expression for the output parameters have a simple structure of the junction to take into account the homogeneity of doping. For cases with small injections, the emitter layer structure consisting of a base layer. This paper analyzes the factors limiting the efficiency of solar cells with the outlines ideal junction. The loss of energy due to the sharp energy gap, the energy of photons with higher energy gap, the accumulation factor is investigated. This article includes factors reflecting the energy loss in solar cells, the combined resistance of series and parallel to the end . nano structure of organic solar cells is investigated.


Yantai Penghui Copper Co.,Ltd.is a copper smelting enterprises using copper concentrate as the main raw materials.The main products are copper,sulfuric acid,gold,and silver.Production processes includes smelting,acid making,oxygen manufacture,electrolysis,comprehensive recycling.Acid wastewater produced during the production is recycled for energy reduction after treatment.


The air traffic density in the terminal area is high and the traffic situation is relatively complex by the development of aviation, which brings great challenges to controller. In order to understand the flight situation and provide decision basis for controllers, this paper proposes a key flight conflict nodes identification method based on complex network theory and Analytic Hierarchy Process (AHP)-entropy weight method. Firstly, an aircraft state network is established with aircraft as nodes and Airborne Collision Avoidance System (ACAS) communication relations as connecting edges. On this basis, four parameters, node degree, node weight, clustering coefficient and betweenness, are selected as evaluation indexes of node importance, and the weight of each index is determined by using AHP. And entropy weight method is introduced to revise the results. Node importance is calculated through multi-attribute decision-making method to determine key conflict aircrafts. The simulation and experiment on the artificial network and the aircraft state network of a certain day in the terminal area of Kunming Changshui Airport show that the method proposed in this paper can identify the key flight conflict nodes in the aircraft state network, allocate the selected node deployment can effectively reduce the complexity of the aircraft state network, can provide reference for air traffic control services (ATCS), and reduce the allocation difficulty of controller.


The objective of this chapter is to provide an example of a user-friendly interface for knowledge management and information retrieval, through the use of virtual assistants in E-government applications. The chapter is going to provide a short state of the art on virtual assistants technology, highlighting the knowledge management aspects. Two case studies: the Mexican state of Guanajuato, and the Federal Government Citizen's Web Page will be presented and discussed. These case studies provide new insights into access methods, interfaces and ways to query and present information in e-government applications.


Introduction Epilepsy is a condition which varies not only in clinical manifestation and in response to treatment, but also in its underlying mechanisms. A good example of the different modes of seizures' onset are posttraumatic seizures, classified according to their time relation to head trauma, as earliest, early and late. The time varies from seconds to years. These types of seizures require different time and utilise different mechanisms for their occurrence, as do seizures in animal models of epilepsy produced by, for example, penicillin, metrazol, alumina cream or kindling. From a clinical point of view the most interesting are these animal models of epilepsy which imitate a slowly developing process of epileptogenesis. For the purpose of this discussion I would like to mention that the occurrence of seizure does not mean epilepsy. Seizures can easily be provoked in anybody, in man and in animal, but this is not epilepsy. Epilepsy can be defined as a chronic brain state in which seizures reoccur "spontaneously" or without apparent reason, indicating an established neuronal property of electrical discharging. Kindling model of epilepsy seems to possess several features that may be related to clinical problems of epilepsy. These features can be put into three categories of changes: behavioural, electrophysiological and biochemical. These changes are long-lasting and they can be related to epileptic foci in man. For example, cerebral epileptogenicity in hippocampally kindled cats persists for a year and is characterised by interictal spike discharges of consistent morphology and localisation, and by fully developed seizures induced by stimulation (1,2). Moreover, spontaneous seizures including status epilepticus in hippocampally kindled cats, rats (1) and in ferrets (personal observation) have been observed. The seizures are of partial and generalised types. Electrophysiological changes in the form of cortical sensory evoked potential (EP) modification were observed in cortically, amygdalary and hippocampally kindled guinea pigs at least 6-8 weeks after last kindling stimulation (3). Long-lasting biochemical changes are less known, however, a number of neurobiochemical changes has been found indicating that kindling also provides a good opportunity to study such changes in the brain which may be related to the kindling process itself, rather than to the acute effect of seizures. These studies may be performed several months after the last convulsion, thus, avoiding contamination by an ictal event. In brief, we may say that electrophysiological, biochemical and behavioural data suggest than in the kindling model we deal with long-term neuronal changes in which "synaptic plasticity" plays an important role. The term "synaptic plasticity" was introduced by Konorski. It refers to long-term changes in synaptic potency resulting from transient changes in synaptic activity. In a broader sense synaptic plasticity means: 1. the growth of new synapses, 2. the activation of previously "silent" synapses and 3. changes in the efficacy of existing synapses (43). The changes underlying kindling are transsynaptic, widespread and related to anatomically and morphologically specific pathways. One of the most striking features of kindling is the time interval between repetitions of stimulations. The optimal time interval between kindling stimulations is 1-2 days. This important feature may indicate that some progressive neurosynthetic events are involved in the mechanisms underlying kindling. It has been shown that short, one hour intervals between kindling stimulations may have inhibiting effect (6). Such hourly stimulation disrupt kindled seizures, suggesting an inhibitory effect of the massed-trial paradigms similar to that observed in a form of anticonvulsant after-effect of each seizure or long-lasting after discharge


Despite the publicity of nanotechnologies in high tech industries including the photovoltaic sector, their life‐cycle energy use and related environmental impacts are understood only to a limited degree as their production is mostly immature. We investigated the life‐cycle energy implications of amorphous silicon (a‐Si) PV designs using a nanocrystalline silicon (nc‐Si) bottom layer in the context of a comparative, prospective life‐cycle analysis framework. Three R&D options using nc‐Si bottom layer were evaluated and compared to the current triple‐junction a‐Si design, i.e., a‐Si/a‐SiGe/a‐SiGe. The life‐cycle energy demand to deposit nc‐Si was estimated from parametric analyses of film thickness, deposition rate, precursor gas usage, and power for generating gas plasma. We found that extended deposition time and increased gas usages associated to the relatively high thickness of nc‐Si lead to a larger primary energy demand for the nc‐Si bottom layer designs, than the current triple‐junction a‐Si. Assuming an 8% conversion efficiency, the energy payback time of those R&D designs will be 0.7–0.9 years, close to that of currently commercial triple‐junction a‐Si design, 0.8 years. Future scenario analyses show that if nc‐Si film is deposited at a higher rate (i.e., 2–3 nm/s), and at the same time the conversion efficiency reaches 10%, the energy‐payback time could drop by 30%. Copyright © 2010 John Wiley & Sons, Ltd.


As a special type of heat exchanger,air cooler played more and more important role in petrochemical fields.As cooling medium was air,air cooler was a energy - saving equipment compared with water cooler.The process parameters,the application conditions,and features of the plant layout and the piping layout of air cooler were introduced, which provided a theoretical basis for selection and layout design.


ABSTRACT The purpose of the present study was twofold: to enhance children's listening by promoting the use of self-regulative skills, and to examine the effects of the mode of presentation of a comparison rule on listening skills. Forty-two kinder- gartners and first graders were involved in two rule-utilization sessions under one of the following conditions: interrogative mode, declarative mode, and control. These two sessions were followed by two posttests, in which the children were not prompted to use the comparison rule. The children who were exposed to the rule detected more ambiguous messages than did the children in the control group during rule-utilization sessions, and the interrogative mode improved the 5-year-olds' listening skills, but not the 6-year-olds' listening skills, more than the declarative mode did. The results of the present study indicate that young children's comprehension monitoring skills have been underestimated in previous research, and they stress that different modes of ru...


This thesis project aims to create an overview of new technologies in printed circuit board manufacturing which when automated could become part of an Industry 4.0 production flow. Potential design ...


Breast tumors contain both transformed epithelial cells and non‐transformed stroma cells, and accumulating experimental evidence strongly suggests that this heterogeneous tumor microenvironment influences tumor growth and metastasis. Previously, we demonstrated that MAPK/ERK kinase kinase 1 (MEKK1) regulates gene expression in fibroblasts and breast tumor cells, and that transgene‐induced breast tumor metastasis is markedly inhibited in MEKK1‐deficient mice. In this work, we utilized expression array analysis of heterotypic cell cultures to determine the role of MEKK1 in stroma gene expression induced by breast tumor cells. We discovered that the breast tumor cell line MDA‐MB 231 constitutively expresses fibroblast growth factor 5 (FGF‐5), and that exposure to either tumor cell‐conditioned media or recombinant FGF‐5 induces chemokine expression in mammary fibroblasts. We demonstrate that FGF‐5‐induced expression of C‐C Motif Chemokine Ligand 5 (CCL5/RANTES) is markedly reduced in MEKK1‐deficient mammary fibroblasts, and that CCL5 expression requires MEKK1 kinase activity but is independent of MEKK1 ubiquitin ligase activity. Furthermore, we report that FGF‐5 initiates MEKK1 kinase activation and signaling in mammary fibroblasts. Finally, we show that breast tumor cell chemotaxis induced by fibroblasts is markedly inhibited by exposure to the CCL5 receptor antagonist Maraviroc, and that MEKK1‐deficient mammary fibroblasts are significantly less effective at promoting tumor cell chemotaxis than cells that express MEKK1. Overall, our findings suggest that MEKK1 is a key regulator of the stroma cell response to tumor cell‐derived FGF‐5. We conclude that MEKK1 is part of the signaling mechanism regulating a tumor/stroma paracrine loop that influences function of both transformed cells and stroma cells within breast tumors. Future studies in our lab will investigate the utility of the FGF‐5/CCL5 signaling axis as a set of targets that can be therapeutically inhibited to reduce tumor growth and progression.


A polymeric semiconductor material——g-C3N4 are currently studied by researchers as hot materials due to their excellent mechanic,optical and electrical properties.Base on analysis of structure and theoretical calculation,the reasons that g-C3N4 can be metal-free catalyst were discussed.The preparation and properites of different modified g-C3N4 including meso-porous g-C3N4,inorganic elements doped g-C3N4,metal-supported g-C3N4,g-C3N4/metal oxides composites and organnic compound modified g-C3N4 were summarized,and the mechanism,effect factors and research developments on the reaction of splitting water for hydrogen revolution catalyzed by above-mentioned modified g-C3N4 were focused on.The opinion on further studies are also presented in this article.


This paper discusses the applicability and features of modal analysis techniques applied to automotive exhaust systems. Modal parameters are obtained by means of shaker as well as engine excitation (running mode analysis). During the modal analysis experiments with shaker excitation, attention is paid to the choice of the excitation signals, the excitation points, the boundary conditions and finding the suitable parameter estimation technique. Next, the estimated modal model is used to perform a reduced sensitivity analysis of the exhaust system. The correlation between the results of the modal analysis and the running mode analysis is analyzed and found discrepancies are discussed.


New multi-site daily discharge simulation method need be developed,because more information is needed accompanying with the rapidly increasing construction of reservoirs.In this study,a new multi-site daily flow simulation model was proposed,in which the daily flow of key gauging station was simulated by an autoregressive model.The copula function was built to describe the temporal and spatial dependence between the key gauging station and others.At last,the daily flows of other sites were obtained using the copulas.The upper Yangtze River was selected as a case study.The daily flow of six sites,including the Yichang in the Yangtze River,Pingshan in the Jinshajiang River,Gaochang in the Minjiang River,Lijiawan in the Tuojiang River,Beibei in the Jialingjiang River and Wulong in the Wujiang River,were simulated.The results indicated that the difference of characteristic values between simulated and observed series were small and the proposed method is superior to the current methods.This study provides a new way for stochastic simulation of multisite daily flows.


The utility model discloses a composite office desk, comprising two side desk plates and an upper desk plate. The side desk plates support the upper desk plate. The upper desk plate and the side desk plates are all or partially plastic composite plates; each plastic composite plate comprises a surface plate, a bottom plate, a honeycomb plate, and an inner liner member. The honeycomb plate is filled between the surface plate and the bottom plate, the inner liner member is clamped between the surface plate and the bottom plate, and the inner liner member is completely coated over the honeycomb plate or is coated over the honeycomb plate with intervals. The type of connection of the two side desk plates and the upper desk plate is a suspended type. With the composite office desk of the utility model adopting plastic composite plates, the strength is high and the weight is light; with the type of connection of the two side desk plates and the upper desk plate being a suspended type or a threaded connection, the connection strength is high and the firmness and the reliability can be ensure. The suspended connection structure is the dismountable connection structure, so the space occupation is small at the time of storage and transportation. With the plastic composite plates comprising plate, the bottom plate, the honeycomb plate, and the inner liner member, the strength is high, and the weight is light.


A novel coronavirus infection was described in 2019 in Wuhan, China. From the first months of the spread of the infection around the world, evidence began to appear that patients after recovery had various symptoms. Duration, intensity, and variability of symptoms vary among patients and are often not associated with the severity of the most acute illness. Recently the concept of post-COVID syndrome (post-COVID or long-COVID in the English-language literature) has acquired increasingly clear diagnostic criteria. Persistent symptoms and / or the appearance of delayed complications after 4 weeks or more from the onset of symptoms of an acute illness are commonly called post-COVID syndrome. The wide range of symptoms that can occur in patients with post-COVID syndrome is now a major health concern worldwide. A proper clinical evaluation will help determine the etiology and build a treatment plan. Longer studies aimed at identifying the effects of COVID-19, possible risk factors for their development, a detailed study of the pathogenetic mechanisms of SARS-CoV-2, and the development of treatment and rehabilitation methods to improve the mental and physical health of surviving patients are relevant elements of study for the foreseeable future. T-lymphocytes are a poorly studied population of T lymphocytes. These cells are more often localized in the mucous membranes of the body which have the properties of innate and acquired immunity. The main biological functions are cytolysis, immunoregulation which indicates an important immunocompetent role of this type of cell population in severe infectious diseases. This article provides information on the fraction of T-lymphocytes during the formation of adaptive immunity in patients with post-COVID syndrome.


Promoting the use of Renewable Energy (RE) resources has become one of the top government agendas throughout the world. However, in order to develop RE such as Concentrating Solar Power (CSP) in Malaysia, several key factors that affect the performance of this system should be thoroughly investigated. Therefore, this paper aims to investigate the feasibility of implementing Parabolic Dish (PD) based on CSP in Malaysia by evaluating the CSP technologies, Meteorological data, Direct Solar Irradiance (DNI), global Parabolic Dish development, sites selection, and Levelized Cost of Energy (LCOE) of the PD system.


Damping of torsional vibrations of ship engine crankshafts - general selection methods of viscous vibration damper This paper describes causes of torsional vibrations generated in ship engine crankshafts. Means for damping the torsional vibrations as well as general methods for selection of viscous torsional vibration dampers for a given type of engine are also presented. Exemplary results of calculations connected with selection of a viscous torsional vibration damper intended for a six-cylinder engine, are attached.


The biggest advantage of Marxist idea of space and time is that it is open,dynamic,capable of change and enhancement with the development of practice so as to form a new space time concept which closely interlinked with times.The scientific outlook on development is rich with Marxist philosophy,whose theories and practices can closely associated with the present time,and thus gain the theoretical support in the history of the development of space and time.The scientific outlook on development not only fully manifests the essence of the Marxist concept of social space and time,and extends its theory and practices,but also provides an extension of space and time for the further development for the mankind.


The purpose of the study is to study the theoretical foundations for ensuring the economic security of entrepreneurial activity, as well as to develop the main ways to improve the economic security of entrepreneurial activity in Russia. Tasks: consider the main theoretical approaches to determining the essence of the economic security of entrepreneurship; identify the main challenges and threats to the economic security of business activities; to characterize the modern features of the development of entrepreneurship in Russia; identify current trends in the development of entrepreneurship and ensuring economic security. The methods underlying the methodology of this study include general scientific methods of cognition, primarily analysis and synthesis, a dialectical, systematic and integrated approach to studying the problems of ensuring the economic security of entrepreneurial activity. The results of this study confirmed that in order to ensure the safety of entrepreneurial activity in the Russian Federation, further monitoring of the national economy and society is necessary, as well as the development of threshold, maximum permissible values of economic and social parameters. Without proper support from the state, ensuring economic security is impossible. In this regard, it is necessary to develop existing measures to ensure the economic security of entrepreneurial activity.


The use of the microdiffusion unit for the determination of blood urea has been described by Conway and O'Malley (1942). Recovery of urea added to blood when estin;ated by this method is precisely quantitative as compared with a 98 to 99% recovery given by the aeration method (Kay and Sheehan, 1934). The method has been found very useful for routine laboratory determinations, especially when dealing with large numbers of samples. Conway (1939a) has also described a method for determining total nitrogen, using the diffusion cell to estimate the ammonia after digestion by the usual Kjeldahl technique. A modification of the method so that the same reagents as those used for blood urea estimation can be employed is described. The method is of considerable value, especially when only small amounts of sample are available or large numbers of estimations have to be performed, since distillation is avoided and all titrations may be carried out together, if necessary on the day after setting up the units.


Author(s): Williams, Preston Bryan | Advisor(s): Wang, Yinsheng | Abstract: The genetic code contains all the information needed to execute every biological task in cells. Although this information is encoded in DNA, proteins are the primary players that execute the biological functions. Understanding how DNA is recognized and regulated by cellular proteins is crucial to gain a deeper understanding of cell biology. Recent advances in mass spectrometry instrumentation allow the investigation of large portions of the proteome simultaneously, making it an attractive technique to examine DNA-Protein interactions. In this thesis, we aimed to develop a quantitative proteomic approach to identify novel nucleic acid-binding proteins. In chapters 2 and 3, we developed and applied a quantitative proteomic method to identify proteins that recognize non-canonical G-quadruplex (G4) DNA. G4s are important biological players due to their genomic locations and their roles in functional biology. We investigated the interaction proteomes of three unique G4 structures. Our technique facilitated the identification of 84 proteins that preferentially bind to G4, including NSUN2 and SLIRP. Upon further investigation, we demonstrate that NSUN2 is a selective binder of G4 structures derived from the promoter of cMYC and cKIT genes, but not that from the human telomere. In chapter 3, we characterized the binding of SLIRP to G4 DNA. We demonstrated that SLIRP can selectively bind all three G4 DNA patterns with low nanomolar binding affinity; the protein, however, exhibited significantly lower binding affinity to single-stranded DNA. Using site-directed mutagenesis, we found that L62 and R24/R25 in the RNA recognition motif of SLIRP are key residues for G4 recognition and binding. In chapter 4, we extended our technique to identify the proteins that interact with two tandem DNA lesions, cdA and cdG. We uncovered 33 proteins can bind to duplex DNA harboring a site-specifically incorporated cdA and/or cdG lesions over their unmodified counterparts. We investigated further one of the putative cdA- and cdG-binding proteins, CDKN2AIP. We knocked out the CDKN2AIP gene and discovered that CDKN2AIP-/- cells displayed significantly poorer survival than wild-type cells when challenged with DNA damaging agents that can induce cdA and cdG lesions, but not those agents that induce other types of DNA lesions.


A much awaited moment in the history of Nepal - the signing of a new constitution, by the first ever elected Constituent Assembly of Nepal, was marred by wide protests. This was an event for which Nepal and to a very large extent Nepal watchers across the world, had been waiting for quite some time. However, the document failed to recognise the demand for dignity and space from a significant section of Nepalese population: the people of Tarai (plain lands).What followed were protests by the people of Tarai against the newly signed Constitution, using a technique of agitation that has been very generic to the Nepalese way of politics. This resulted in a blockade of Nepal-India connecting land routes that have been central to most of the supplies to this landlocked state. What was of utmost significance in this phenomenon was a blame game; an accusation pointing towards India, that this blockade was entirely contrived and encouraged by it. Consequently, relations between the two otherwise very friendly countries dipped to an all-time low. This is not an unfamiliar narrative in the saga of India-Nepal relations.The recent phase of social and political turmoil in Nepal is an indication of Nepal's incapacity to integrate the people of the Tarai, the Tharus and the Janajatis, and its inability to recognise them as equal trustworthy citizens.The deliberate disregard of the wishes of the people of the Terai with regard to the demarcation of internal boundaries of federal units, and the strange discriminatory provisions against women by a country that has been otherwise most progressive (for instance, Nepal is the only South Asian country to grant constitutional rights to the LGBT community), are not easy to comprehend. There has to be more than what meets the eye. Nonetheless, the demarcation of the provinces in deliberate refutation of the wishes of the people of Tarai demonstrates the suspicion Kathmandu has towards the emotional bonding or, in more crude terms, the loyalty that Madhesis have towards their own country. In the same vein, the generic understanding among the Hill people seems to be that most of the Tarai women marry men from India, extending citizenship to their offsprings by birth, (not by naturalisation as is the case under the current constitution). This, they think, runs the risk of Nepal not only losing its national identity but also its seats of power to persons of Indian origin.The blockade that continued for four and a half months brought severe privations to people for the past several months. As has been the trend in the past, this agitation was interpreted in Nepal as one of India's making, and as a tool for interfering in the internal affairs of the country. It was largely understood as an event instigated and supported by India.Of the various ups and downs that India-Nepal relations have experienced, this has by far been the most dismal phase in their bilateral relations. At the same time, Nepalese tilt towards China has gained unprecedented momentum. Popularity of China has grown immensely in Nepal and is often juxtaposed with India. China's "non interference in the internal affairs of Nepal", has been much appreciated, often standing in contrast to a growing Nepalese refrain: "India's interference in the internal affairs of the country".Coming on the heels of a devastating earthquake, Nepal has not had a very happy past to take reprieve from. Also, Nepal had not even fully recovered from a decade-long (1996-2006) civil war that killed over 16,000 persons, made a sizeable number "disappear", and turned many of Nepal's democratic institutions defunct. The peace agreement of November 2006 was an inclusive agreement that placed all the players in Nepali politics on a level field: the rebel Maoists, the Nepali Congress (one of the oldest political parties of Nepal), the Unified Marxist Leninist (Communist Party of Nepal, UML) and the Madhesi parties (political parties from the southern plains). …


Artificial systems such as the existing traffic system function without natural control mechanisms. Technical systems (constructionally and mechanically technical) which operate by interaction with humans require control mechanisms which are based on a knowledge of physical conformity and human behaviour patterns and which should be effective mechanisms for keeping within the law. If these control mechanisms are considered too late incorrect developments can start, which can only be controlled technically and legally with difficulty. Similarly there is a danger that when mental and physical limits are passed by traffic technology and legal measures, permanent infringements of the law are the consequence which can lead to a lack of effectiveness of the intention of traffic technology. If these effective mechanisms are changed by legislation, then naturally consequences in traffic technology come to light which can lead to considerable changes in the overall system with respect to construction and running costs and road safety. These two areas must therefore be in agreement in order to ensure reasonably safe and economical operation. (TRRL)


Less refined sweeteners may impact metabolism differently from their more refined counterparts. We have demonstrated that agave nectar may beneficially alter metabolism in mice in comparison to sucrose. Since agave nectar is particularly rich in fructose, we hypothesized that it would promote lower acute glycemic responses but may promote gastrointestinal (GI) discomfort in comparison to sucrose. We also assessed satiety responses to the sweeteners. Healthy young adults (n=21) between the ages of 20‐45 years completed two randomly ordered feeding trials in which they consumed 200 ml of a test beverage providing 50 grams of carbohydrate from sucrose or raw agave nectar mixed in water. Glycemic responses were examined by finger prick at baseline and 15, 30, 45, 60, 90 and 120 minutes post‐feeding. Symptoms of GI discomfort (nausea, cramping, distention and flatulence) were self‐reported using visual analogue scales at the same timepoints. Satiety was assessed by visual analogue scale at baseline and every 15 minutes for two hours. Agave nectar consumption elicited significantly (p<0.05) lower blood glucose concentrations over time compared to sucrose. Although the magnitude of nausea was relatively low for both trials, greater (p<0.05) nausea was reported during the agave nectar trial. No other symptom of GI discomfort was differentially affected. No significant differences were observed for satiety responses between the two sweeteners. Results suggest that raw agave nectar as a less refined sweetener promoted lower blood glucose responses in young healthy adults as well as modest GI discomfort. Future research should assess the acute and chronic ingestive effects of this sweetener in healthy individuals and those with metabolic disorders.


Newspaper clippings of an article from the Dallas Times Herald, dated Sunday, December 20, 1987, originally published in The Washington Post by Laura Sessions Stepp. The article discusses the Rev. Jerry Falwell's decision to relinquish the presidency of Moral Majority, resign as chairman of The PTL Club, and limit his involvement in national political issues. The article suggests that Falwell may redirect his efforts to preaching at his Thomas Road Baptist Church in Lynchburg, Virginia, broadcasting "The Old Time Gospel Hour", and attending to affairs at Liberty University, which Falwell founded in 1971.


By designing a questionnaire,we conduct a sample survey on full-time professional degree postgraduates enrolled in 2009 by graduate schools in 36 universities and analyze its results.We find from the survey that the acceptance of the professional degree among professional degree postgraduates is not high,which exerts remarkable influence on the quality of training.The process of training can not fully reflect the features of professional degree education up to now.Such factors as the process of classroom teaching,the pertinence of supervisor's instruction affect the outcome of postgraduates' study.In order to promote the further development of the professional degree postgraduate education in our country,we must deepen the reform of the professional degree postgraduate training mechanism,intensify the differences between professional degree and academic degree,improve the training quality and facilitate the connection between the professional degree education and professional qualification.


Design for environment(Dfe) rules of Electrical products from European Union WEEE Directive and China WEEE are introduced.Reuse of components is a key factor of Dfe.Chip Resistor is widely used in PCBA for long life cycle,so it is a good kind of reuse component.Process problems of influencing on reuse chip resistor reliability are discussed,for example,mechanical stress and thermal stress,environment corrosion,intermetallic(IMC) growth.Failure models caused by these process problems and analysis methods are introduced at the same time.


This study took place in the city of Feira de Santana (BA), with the objective of analyzing the perception of body image by women with mastectomies who attended an oncology clinic. The study used a qualitative approach. The instrument for data gathering was the semi-structured interview with nine women with mastectomies under oncologic treatment. The results obtained allowed for the identification of convergent and divergent accounts regarding the way of thinking of women with mastectomies. These accounts helped to unveil feelings related to the symbolization of the breast, the impact of the diagnosis of breast cancer, mastectomy in their day-to-day, and the perception of their self-image. Health professionals, family members, and support groups must consider mastectomy in the life of women, aiming to help women during their social readjustment and maintenance of their self-esteem.


Objective To study the key factors affecting the formation of callus of Paris polyphylla.Methods The explants(rhizomes,lateral roots,stems,leaves and seeds) were cultured on the MS basal medium with supplement of various combinations ofphytohormones.Results Callus could be induced successfully from the seed embryos only with the method of nursing culture of endosperm.It's also found that IAA exhibited the greatest capacity to improve the induction of Paris callus among tested phtohormones,however,6-BA possessed stronger ability in regulating the differentiation of Paris callus than IAA did.In addition,it's demonstrated that the formula of MS+2 mg·L-1 IAA+0.02 mg·L-1 6-BA was proven to be better for the induction of Paris callus,and achieved a maximum induction rate of 53.3%.Conclusion Appropriate explants and combinations of phytohormones might play pivotal roles in inducing the formation of callus of Paris polyphylla.


The present invention relates to a super absorbent resin which generally exhibits balanced and superior physical properties through the optimization of retention capacity, absorption under pressure, liquid permeability, and gel strength. This super absorbent resin comprises a cross-linked polymer obtained by surface cross-linking a powder type base resin prepared by polymerizing water-soluble ethylene-based unsaturated monomers having an acidic group of which at least a portion is neutralized, and the centrifuge retention capacity (CRC), absorption under pressure (AUP), gel strength (G'), and saline flow conductivity (SFC), of the super absorbent resin can satisfy predetermined relational expressions.


Optical disc drive (1) is 4 optical pickup with a split photodetector (20) (3), movably mounted objective lens relative to the photodetector (20) (14), the objective lens (14) the optical movement actuator for moving the (30), and a servo controller (70) for controlling the focal actuator (30). Controller (70), the light detector from the (20) receives the detection signals (S1, S2, S3, S4). Controller (70) processes these detection signals, is adapted to generate a zero focus error signal (FE) when these signals are all the same size. Controller (70) further that the focus error signal to (FE) by subtracting / adding the offset parameter (phi


It is well recognized that looking for new physics at lower energy colliders is a tendency which is complementary to high energy machines such as LHC. Based on large database of BESIII, we may have a unique opportunity to do a good job. In this paper we calculate the branching ratios of semi-leptonic processes $D^+_s \to K^+ e^-e^+$, $D^+_s \to K^+ e^-\mu^+$ and leptonic processes $D^0 \to e^-e^+$, $D^0 \to e^-\mu^+$ in the frames of $U(1)'$ model, 2HDM and unparticle separately. It is found that both the $U(1)'$ and 2HDM may influence the semi-leptonic decay rates, but only the $U(1)'$ offers substantial contributions to the pure leptonic decays and the resultant branching ratio of $D^0 \to e^-\mu^+$ can be as large as $10^{-7}\sim10^{-8}$ which might be observed at the future super $\tau$-charm factory.


The invention discloses a method for synthesizing a standard substance of a degradation impurity of bromfenac sodium sesquihydrate. 7-(4-bromobenzoyl)indoline-2,3-diketone is adopted as a raw material and subjected to hydrolysis and refining to obtain a purified product of 2-(2-amino-3-(4-bromobenzoyl)phenyl)-2-oxo-acetic acid, and content calibration of the purified product is realized by conventional analysis means. The method is simple in process and short in preparation cycle, and calibrated product content is higher than 97.0%. The bromfenac sodium sesquihydrate impurity synthesized according to the method can be used as a standard substance of the impurity and applied to qualitative and quantitative research and detection of impurities in raw materials and preparation of bromfenac sodium sesquihydrate.


The flag of the Republic of Ireland enshrines two distinct traditions. The Green represents the Nationalist and the Orange the Loyalist. Traditionally these colours have been associated with different cultural and theological views. In focusing on the Presbyterian Church in Ireland (PCI), this dissertation seeks to engage with a denominations whose history includes evangelism, Church extension/ planting and ecumenism. PCI's activity is set within the wider context of "mission-as-evangelism and ecumenism" in and from Ireland. This research aims to discern PCI's theological justification for mission-as-evangelism and ecumenism. PCI's mission-as-evangelism and ecumenism is considered in respect to a theological and practical understanding of and relationship to the Catholic Church. Attention is given to a theological consideration of PCI's historical and confessional position on Catholicism. Further, attention is given to how PCI, in reflecting their historical and theological position on Catholicism, can engage with Catholicism through missionas-evangelism and ecumenism. This dissertation considers the theological question whether the doctrinal tenets of confessional Presbyterianism are a hindrance or an aid to mission-as-evangelism and ecumenism. In asking this question, this research seeks to respect the theological and historical traditions of the Reformed Churches and to highlight the contribution of Reformed theology and Churches to the belief and praxis of mission-as-evangelism and ecumenism. This research seeks to highlight the mutually informative relationship between evangelism and ecumenism. This relationship is investigated to understand how they enrich one another. The possibility of mutual enrichment leads to the question whether both the evangelical and ecumenical perspectives can be adopted with integrity, in the light of the historical and confessional theology of the PCI. This research also seeks to discern whether the evangelical and ecumenical positions are mutually exclusive with regard to their theology and ecclesiology. The theological question is filtered through Irish Presbyterianism within the matrix of Ireland.


The utility model belongs to the bearing detecting technique, which provides a cantilever support and a loading mechanism in a detecting device of a thin-wall bearing of a helicopter tilting device, wherein a cantilever supporting mechanism thereof is used for locating the axial direction and the radial direction of a testing bearing (9) and enables the testing bearing to be positioned on one end of a main shaft and in a cantilever structure, the mechanism mainly comprises a bearing outer sleeve (10), a rotationally-linked flange (11), a bearing seat (7) and a flange (6), wherein a loading rod (32) in the loading mechanism is pivoted with an axial load loading hydraulic cylinder (2) through a knuckle bearing (4), a connecting disc (5) is fixedly linked with a loading rod (32) and is linked with the flange, and two torque loading hydraulic cylinders (28) are connected with the loading rod (32) through the knuckle bearing (4) and enables the loading rod (32) to be connected with the connecting disc. The cantilever support and the loading mechanism of the detecting device of the thin-wall bearing of the helicopter tilting device, which are provided by the utility model, have scientifically and reasonably designed structures.


Resistant hypertension (RH) is an important cause of cardiovascular morbidity and mortality. Both true and pseudo-resistant arterial hypertension (AH) represent a big problem not only in blood pressure (BP) control, but also in those possible adverse cardiovascular events, the development of which is associated with failure to achieve target BP levels.
 The aim of the study was to establish the features of hemodynamic and metabolic parameters in obese patients with true and pseudo-resistant AH.

 The study included 200 patients with uncontrolled AH and obesity. Patients were initially prescribed dual antihypertensive therapy. Those patients who did not reach target BP levels after 3 months on dual therapy were additionally assigned a third antihypertensive drug. Of the 98 patients who were assigned triple therapy, 48 patients did not reach target BP (27 patients had pseudo-resistant and 21 patients had true resistant AH). These patients were additionally prescribed a fourth antihypertensive drug (spironolactone). The effectiveness of the treatment was evaluated 6 months after the start of antihypertensive therapy.

 After 6 months of therapy, patients with RH had higher body mass index (BMI) and higher BP levels compared to patients without this condition. Patients with RH also had more pronounced cardiovascular remodeling, higher levels of triglycerides, insulin, HbA1c, more pronounced insulin resistant (IR), which was confirmed by greater HOMA-IR, greater imbalance of adipokines, proinflamation activity and higher activity of the renin-angiotensin-aldosterone system (RAAS). A comparative assessment of pseudo-resistance and true resistance showed that patients with true resistance differed from pseudo-resistant patients with significantly lower BMI (p=0.02). In addition, in the absence of differences in BP levels, cardiovascular remodeling, lipid and carbohydrate profiles, patients with true resistance had significantly higher levels of aldosterone (p=0.04), higher activity of oxidative stress (malonic dialdehyde, p=0.01 and diene conjugates, p=0.03), a lower level of total antioxidant protection (p=0.00), a higher level of adiponectin (p=0.00), and a lower level of leptin (p=0.00), compared with pseudo-resistant patients.

 Patients with resistant hypertension differed from hypertensive obese patients without resistance with higher BMI and BP, higher levels of triglycerides, insulin, HbA1c, more pronounced IR, cardiovascular remodeling, imbalance of oxidative stress - antioxidant protection system, higher proinflammatory and RAAS activity. Patients with true resistance differed from pseudo-resistant patients with significantly lower BMI, higher aldosterone levels, more pronounced imbalance of the system of oxidative stress - antioxidant protection and less pronounced adipokines imbalance.

 Type of funding source: None


Skill at reading textbooks is clearly important for academic success but instead of reading their textbooks, many college students skip difficult sections and memorize surface information they think will be on tests. This study reports an evaluation of factual study questions as a component of an introductory psychology course taught to developmental students with a computer-assisted, mastery learning teaching method based on Keller's (1968) Personalized System of Instruction (PSI). Most students completed the study questions and our correlational analyses showed clearly that study question completion was associated with quiz performance. We recommend that instructors of introductory courses, especially those that serve developmental students, create and use factual study questions.


The genesis of Verdi's Otello is a familiar episode in the history of Italian opera. The semiretired composer's reluctance to reenter the operatic fray, his gradual interest in Arrigo Boito's draft libretto, and the astonishing speed with which he composed the music have been the subject of both musicological and biographical study.1 Letters between librettist and composer detail the textual modifications that Boito made


A three‐dimensional unstructured‐grid hydrodynamic and water quality model (Semi‐implicit Cross‐scale Hydroscience Intergrated System Model‐Integrated Compartment Model) is applied successfully for Chesapeake Bay. The model is validated with observations of salinity, chlorophyll‐a, dissolved oxygen, nutrients, and phytoplankton productions from the year 1991 to 1995 for the mainstem and some major tributaries, based on multiple model skill scores. Model experiments are conducted to test the importance of having (1) an accurate representation of bathymetry to correctly predict hypoxia and other processes and (2) a high‐resolution model grid for tributaries to correctly simulate water quality variables. Comparison with the model experiment results with bathymetry smoothing indicates that bathymetry smoothing, as commonly used for many systems, changes the stratification and lateral circulation pattern, resulting in more salt intrusion into shallow water regions, and an increase in the freshwater age. Consequently, a model with bathymetry smoothing can lead to an unrealistic prediction of the distribution of hypoxia and phytoplankton production. Local grid refinement shows significant improvement of model simulations on local stratification and water quality variables. Overall, the use of high‐resolution unstructured grid model leads to a faithful representation of the complex geometry, and thus a seamless cross‐scale capability for simulating water quality processes in the Bay including tributaries and tidal creeks.


Abstract : We study the feasibility of transmitting whistler mode waves in space for stimulating wave-particle interaction in the radiation belts. We investigated both theoretically and experimentally the antenna-plasma interaction, the whistler waves radiated from a space-borne transmitter, and the VLF waves radiated from ground-based transmitters. We have developed a one-dimensional model of the high-voltage-antenna-sheath-plasma both analytically and numerically, and compared the results with the space transmission experiments made by the Radio Plasma Imager on the IMAGE satellite. We have developed a general theory for whistler wave radiation in space. Our results have shown that previous antenna sheath theories need significant modifications and the previous whistler wave radiation theory contains substantial mathematical errors and flaws. The model developed a few decades ago to describe the whistler waves penetrating through the ionosphere and propagating in the magnetosphere also needs significant improvements. This project has laid solid foundation for further investigations and modeling of space-borne whistler transmissions.


The derivation of the Cramer-Rao bound (CRB) in [ldquoPerformance Analysis of the FastICA Algorithm and Cramer-Rao Bounds for Linear Independent Component Analysis,rdquo IEEE Trans. Signal Process., vol. 54, no. 4, Apr. 2006, pp. 1189-1203] contains errors, which influence the matrix form of the CRB but not the CRB on variance of relevant off-diagonal elements of the demixing matrix. In this correspondence, we correct these errors.


A revised computer-based wildlife inventory programme has been developed to aid the collation and mapping of fauna and flora information. Field data woks have been produced to facilitate the collection of significant records in a format that is easy to handle. Current maps for the records for the terrestrial vertebrate classes are presented.


Properties of binding curves The binding polynomial (nonassociating macromolecules) Allosteric systems Physical binding phenomena Ligand control of aggregation Ligand linkage between macromolecular phases The thermodynamics of macromolecules.


According to archaeological data, the social status of Scythian women was lower than that of men. Still, due to some contradictory evidence obtained from a number of female burials the revealed subordinate position of the woman in Scythian society cannot be recognized as a final conclusion. Those include mound burials that are similar enough in terms of prestige to those of men by a number of criteria, namely: those are central or accompanied by horse graves, or are situated along the same meridian line as the central tomb; and they were even disturbed in the same manner during post-burial rituals. The most characteristic female burial of the type is that of the Melitopol´ kurgan, the former was aligned with that of a male, has additional large-scale earthwork and reveals traces of a post-burial ritual disturbance. It is noteworthy that in traditional nomadic cultures - especially those unaffected by Muslim religious ideas - women were recognized equal to men upon reaching advanced years or a particular life-cycle stage since the earliest times.


THE CROSSING BETWEEN CHILDHOOD and adulthood, the teenage years, is a perilous journey as one learns to chart the cultural and political realities that lie beyond the world of home and family. For First Nations students, high school involves an intense encounter with the themes of ethnicity, power, and history that define adult relations between the reserve and the surrounding dominant society. Aboriginal people's high school memories are charged with struggles to assert cultural identity in an institutional landscape that has pushed their reality to the margins. They have had to navigate a delicate terrain that has been indifferent, or hostile, to their own communities' values and beliefs. Some Aboriginal teenagers found ways to cope with the schools' institutional racism. Most just tried to survive; a few graduated, but often without the academic or technical skills to compete in the white man's frantic, unbalanced world. More recently, with increased postsecondary access and with the advent of First Nations control of education, Aboriginal youth have had some new choices and have taken advantage of opportunities to invigorate their own communities' economic and cultural renewal. Conditions have changed; the social and political landscape for Aboriginal peoples has evolved, with unanticipated layers of complexity. Globalization has created new challenges for self-determining indigenous communities and for youth attempting to resurrect and understand Aboriginal identity in a modern and postmodern context. In advancing the work of healing and revitalizing First Nations communities, we need to understand the present conditions for Aboriginal teenagers and their families. We also must come to understand how these conditions have evolved from the political climate of the recent past. Residential schools left a potent legacy of language and culture


The invention relates to a liquid blast furnace slag granulating device which comprises a slag melting bin, a granulator, a granulating bin and a rectifying cavity, wherein the granulator is positioned in the center of the integral device, mainly comprises a rotating disc, a high-speed rotating shaft and a speed regulating motor and is used for centrifugally granulating liquid slag into fine granules; the rectifying cavity is positioned at the periphery of a position lower than the rotating disc, comprises a ventilation hood and a ventilation pipe group bottom plate and is used for regulating cooling wind speed. The equipment disclosed by the invention does not consume the water resources, can be used for efficiently recovering the heat, is favorable to energy conservation and environment protection, is high in slag granulating speed and can intermittently work; the granulated blast furnace slag is high in quality.


"CS for All" has set computer science on an unusual journey. Literacies are skills asked of us all: thus, "CS for All" identifies computing skills as a full-fledged human literacy. Yet, Computer Science departments are not uniformly ready to build a computing literacy for all students. This project has investigated on how different institutions are coping with this challenge. We share the results of a 50-institution curricular survey, tracking CS course offerings for a variety of cohorts outside the CS major. We add additional detail to this big-picture snapshot with data from a ten-year experiment offering a biology-and-computing introductory course. The downstream outcomes are heartening in both computing skills (no difference at all in subsequent performance relative to a peer control-group) and in spurring overlapping interest. We also share several new paths, termed "bridges" and "injections," to help computing contribute to the academic identities of students in other disciplines. Just as cogent writing, critical reading, and compelling speaking are today/s hallmarks of literacy, the future may ask us to make computing part of our common goals and expectations. Through local and national data, this project is exploring new curricular paths with the goal that CS in many forms -- as a discipline, as an academic department, and as an identity of its own -- can fully support the challenge of "CS for All."


Abstract Electronic legal education involves the use of information, communication and instructional technologies to enhance students' learning of the law and to provide law teachers with environments and tools for teaching the law. With the fast growth of the Internet many Law schools and Law faculties are moving their education and training into web environments. This may open new ways of teaching and learning the law by providing students with an environment in which they can manage legal information and legal knowledge for their personal professional use. However, it is clear that throughout Europe there are divergent as well as convergent uses of the web and IT This article explores some of the issues inherent in this, and suggests a number of projects that would enable ICT in legal education to facilitate the aims of the Sorbonne‐Bologna process.


Extreme loading threats arising from terrorism, war zones, natural disasters, and even accidents, require specialised protection in order to limit and prevent death and damage to infrastructure and vehicles. In particular, soil blast loading is of concern due to the increased loading imparted by the dual phase explosive/soil mix. Smart, more efficient structures are required to better protect against these kinds of threats. Auxetics, structures and materials with a negative Poisson's ratio, are one such novel structure which have seen increasing research as protective structures. Their counterintuitive nature means they contract under a compressive load and vice versa. This phenomenon draws materials towards the point of impact and can lead to increased energy absorption, indentation resistance, and fracture toughness.

This research investigates the auxetic oval structure for its protective capabilities with a focus on energy absorption. Quasi-static and dynamic testing was conducted on samples to quantify the response over strain rates ranging between 0.001-100 /s. It was found that the auxetic oval structure displayed the classic stress-strain response for energy absorption with a flat plateau stress region. However, fracture was present in the experiments and shown to negatively affect the energy absorption. A Hybrid design utilising another auxetic geometry, the re-entrant honeycomb, was developed to remedy this issue. Digital image correlation (DIC) was also used in the analysis of the experiments to confirm the presence of the rigid rotating square mechanism controlling the auxetic behaviour.

Numerical models were then developed in finite element software LS-DYNA and validated against the stress-strain response and DIC analysis from the experiments. Further understanding of the energy absorption mechanisms were identified through the numerical models, including the locations of plastic energy dissipation. Parametric studies were then conducted from which different behaviour characteristics were tied to geometric features. Most results were intuitive, such as the plateau stress being tied to the thickness of the material between holes. However, additional insight was revealed about how the thickness negatively affected the Poisson's ratio, i.e. thicker sections changed the load transfer response and thus negated the auxetic effect. Only one parameter, the oval ratio, was shown to directly affect the densification strain, which was due to the available space the holes could collapse in. Finally, load rate studies showed how the auxetic oval structure was characterised by uniform crushing for load rates up to 10 m/s. Above 200 m/s the auxetic displayed localised crush band formation.

Soil blast loading was quantified through flying plate tests conducted with 0.5 kg TNT charges buried within an unsaturated soil. The impulse imparted to the plates can be used to determine the loading imparted to a protective structure. It was also used to validate numerical models of soil blast events in LS-DYNA using the Arbitrary Lagrangian-Eulerian (ALE) method. The soil model was populated with data from soil characterisation tests. Good agreement between the experiments and models was generally achieved. Further work on understanding the loading mechanism of soil blast was then conducted. It was determined that ~63% of the impulse was from the soil alone. Furthermore, the spatial and temporal loading was determined through additional numerical models, highlighting the localised nature of soil blast events.

The final body of research investigated the auxetic oval geometry with soil blast loading considered. Simplified localised loading on long auxetic sections showed the benefit of a negative Poisson's ratio over conventional positive Poisson's ratio equivalent structures. This included an increase in relative energy absorption due to the ability to draw material towards the load point. Loading was then simulated recreating the failure scenarios of a vehicle subject to a soil blast event. This was conducted using simplified load models (ConWep) on the auxetic structure, and ALE loading on homogenised foam material models representing the auxetics. Both methods highlighted the benefits of the auxetic oval structure over conventional protective structures, including; reduced stress transmission, increased energy absorption, and decreased global body acceleration.

In conclusion, the auxetic oval structure displays an ideal response for energy absorption, and the localised nature of soil blast is ideal for activating the main benefits of an auxetic structure though material densification and load redistribution.


would not join the Communist-dominated camp for this would enable Moscow "to counter-balance Asia's two leading countries and act as the fulcrum of a seesaw on which India and China could only move alternately up and down." This shows what China has lost by being so completely in the Communist camp. If it had been also like India "in between the two worlds" it would have been sought after by both Russia and the United States and this would have weakened the bargaining position that India enjoys vis-&-vis the two world powers. Similarly, if China is admitted in the United Nations it is very likely that China with its greater population and also perhaps military and economic strength would become an irresistible candidate for leadership of the Asian-African bloc in the General Assembly. "The battle for Asia, as Nehru knows," writes Mr. Moraes, "is not between Russia and America but between India and China."


The invention relates to a preparation method of a waterproof and whiting-resistant silicon-acrylic composite emulsion for interior wall latex coatings. The emulsion comprises the following raw materials: monomers, emulsifiers, initiators such as ammonium persulfate and deionized water. The raw materials are orderly processed through steps of pre-emulsifying the monomer, polymerizing seed emulsion, polymerizing semi-continuous emulsion and finally filtering and discharging. According to the preparation method, vinyl organic silicon, a self-crosslinking system and assistant cross-linking agents are copolymerized with acrylic esters monomers by using pre-emulsification semi-continuous seed emulsion polymerizing method to prepare the silicon-acrylic composite emulsion. Entire preparation process is stable and convenient and is beneficial to achieving mass production. The obtained composite emulsion has the advantages of monomer conversion rate of more than 96%, average emulsion particle size of less than 100 nanometers (nm), good mechanical stability and storage stability, high hardness of film, low lowest film-forming temperature and excellent whiting resistance in water and water resistance.


Based on the origin of the concept about social security and the different comprehension of social security,this paper analyzed the meaning of social security.Main conclusion follows: there is a magnified trend about the concept of social security in China today.Social security include these meanings: the goal is resisting risks and guaranting basic living of national and maintaining social safe,include social insurance and social relief.Social welfare has much more contents than social security.Social security is the basic part and primary phase of social welfare.


This study aims to investigate the effects of group reminiscence therapy on elderly's emotional intelligence. A quasi-experimental research with a pre-test-post-test control group was conducted in July 2015, with a sample of 40 elderly members referring to an (anonymous) Community Center in the city of Shiraz, Iran. A predesigned instrument, i.e ., the Emotional Intelligence Questionnaire developed by Schering, was applied to collect data. SPSS Statistics v. 22.0 (Released 2013; IBM Corp., Armonk, NY, USA) was used to analyze data, with a 95% confidence level and a measurement error of α=0.05. Hypothesis tests were mainly conducted to examine whether group reminiscence therapy correlates with emotional intelligence among the respondents. Findings revealed that the applied intervention i.e ., group reminiscence therapy significantly associates with various dimensions of emotional intelligence including self-awareness, self-control, self-motivation, empathy and social skills in the older adults within the experiment group; i.e ., the mean scores of the variables for the post-test administered on the experimental group were significantly higher than those on the control group. Group reminiscence therapy has the potential to enhance emotional intelligence in the elderly by helping them control their thoughts and emotions and learn problem-solving skills.


The fracture critical (FC) classification was developed and implemented for bridges in which the failure of a single member could lead to failure or collapse of the structure. The FC classification can increase the fabrication cost of the bridge, but far more expensive are the required arms-length biennial in-service inspections. To reduce costs for state highway agencies, it would be beneficial to reconsider the FC designation or, at least, the frequency of the arms-length in-service inspections for bridges, where appropriate. This research evaluated (1) the redundancy of a full-scale 45.72-m (150-ft) truss bridge structure by conducting controlled fracture tests in the field and (2) the use of numerical analysis techniques for quantifying the postfracture behavior and redundancy of the full-scale truss bridge. The experimental results indicate that the truss bridge structure had significant member-level and system-level redundancies, which prevented failure or collapse of the structure caused by failure of the FC member. The numerical models can predict the postbehavior and redundancy of the full-scale truss bridge reasonably well, but with some limitations. The experimental and numerical approaches presented in this paper are recommended for conducting additional investigations, expanding the knowledge database, and eventually for reconsidering the FC classification or the frequency of arms-length inspections.


This thesis contains a description of a novel generalized SOR algorithm for accelerating the convergence of the dynamic iteration method known as waveform relaxation. The new waveform convolution SOR algorithm is presented, along with a theorem for determining the optimal convolution SOR parameter. Both analytic and experimental results are given to demonstrate that the convergence of the waveform convolution SOR algorithm is substantially faster than that of the more obvious ordinary waveform SOR algorithm. To demonstrate the general applicability of this new method, it is used to solve the differential-algebraic system generated by spatial discretization of the time-dependent semiconductor device equations.
The accelerated waveform relaxation algorithm is compared to pointwise direct and iterative methods for the transient simulation of semiconductor devices on both serial and parallel machines. In particular, experimental results are presented for simulations on a small cluster of workstations running the Parallel Virtual Machine (PVM) software, as well as for simulations on a 32-processor Intel iPSC/860. The results show that the accelerated waveform method is competitive with standard pointwise methods on serial machines, and is significantly faster on commonly available loosely-coupled MIMD machines. The parallel accelerated waveform method achieves nearly linear speed-up on the 32 processor Intel iPSC/860 hypercube. The strong implication of the results is that, as MIMD machines become more prevalent, accelerated waveform methods may gain in importance for all areas of simulation requiring the solution of initial value problems. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)


Location prediction has attracted a significant amount of research effort. Given an object's recent movements and a future time, the goal of location prediction is to predict the location of this object at the future time specified. Prior works have elaborated on mining association relationships among regions, in which objects frequently appear, to predict locations. In this paper, first we, pre-process the data for remove the unnecessary locations of the all objects. With the help of the clustering algorithm, we develop an algorithm for mining the cyclic periodic patterns. After mining the cyclic periodic patterns, the prediction of next location can be done with the help of prediction model. This prediction of next location is useful to find the historical movements of objects in future. The proposed mining technique will be implemented using JAVA and the experimental evaluation with the truck dataset will be done to show the effectiveness of our proposed method


Photograph of the road leading to Lohman's Bridge taken during dedication celebration. Several cars are visible on the road and on the new bridge.