Due to the mass imbalance about the center of rotation, the stability of stabilized platform system degrades with carrier's disturbances. Various feed-forward control methods are provided by reaserchers to solve this problem, however these methods are not well applied because the eccentricity of stabilized platform could not be measured directly. The dynamics model of a typical 2-axis stabilized platform is given. The eccentricity vector is identified through Unscented Kalman Filter(UKF) algorithm. Imbalance torque is precisely observed so that the real-time nonlinear compensation for mass imbalance is achieved through a feed-forward loop. The simulation result indicates that the Root Mean Squared Error (RMSE) of parameters estimation is 0.024 after convergence. the LOS stabilization with carrier's 2.5Hz vibration is 0.04 rad/s, which improves 78% compared to conventional feed-back control.


On the occasion of the 50th anniversary of the International Review of Sociology of Religion, Social Compass, here is the letter I received from it. It is addressed to anyone who ever turned its pages, reading perhaps...


Noise level generated by engines and propellers of scientific manned or unmanned subsea vehicles has direct influence on on-board acoustic system performances. Noise measurements at sea are a very expensive operation. Tank measurements are more suited, but reverberation by the bottom, the walls and the surface alters the accuracy of the results. Measurement methods exist in reverberation chambers for aerial acoustics as well as electromagnetism. This communication shows that the transfer of the SABINE law to underwater acoustic measurements can be fully valid. Theory and experiments confirm that in the 15/spl times/10/spl times/6 meters concrete tank of IFREMER, an uniform reverberated field is present. It is thus possible to reach the tank absorption and the reverberation time. The analytic formula which is given allows the prediction of the radiated noise in free field, from the effective measurements done in the reverberated field and the tank reverberation characteristics. Experiments with calibrated noise sources show an accuracy of /spl plusmn/1.5 decibel.


This is the first study to report absolute measurements of cardiac output (Q̇) with Transonic flow probes during prolonged swimming in a salmonid. Simultaneous measurements of hematocrit and arterial blood O₂ content in seawater-acclimated rainbow trout (Oncorhynchus mykiss) (body mass 401-1,025 g) at 10° ± 1° C indicated that the fish were in good physiological condition, while measurements of resting heart rate, arterial blood pressure, and systemic resistance suggested relatively low levels of stress. Maximum Q̇ Q̇max (48. 7 mL · min⁻¹ · kg⁻¹) was reached at 97.3% of the maximum prolonged swimming speed and is similar to the Q̇max estimated by the Fick principle during swimming in freshwater rainbow trout. Maximum Q̇ was 84% greater than the resting Q̇ (Q̇rest) (26.6 mL · min⁻¹ · kg⁻¹) and was brought about by a 38% increase in heart rate (fH) and a 25% increase in stroke volume (SVH). Correlation analysis showed that individual variability in Q̇max was mainly due to variability in maximum SVH ; maximum fH was relatively invariant among individuals. At rest, SVH and fH , were negatively correlated. Individual fish with a high Q̇max were characterized by a low resting fH and a high resting SVH.


Text summarization is one way to get the informatio n which is quite effective. Approach techniques of the text summarization are classified into two, namely abstractive and extractive. This paper is focused o n the extractive techniques so that the output of the app lication is important sentences which are taken fro m the original text intact without modification verbally. There are four majors processes in this research n amely preprocessing stage, scoring features, optimization of summarization by two methods (Fuzzy Logic and Fuzzy C-Means), and extraction of summary results. This research use 7 features to calculate the score of each sentence. The core of this research is to comp are reliability Fuzzy logic and Fuzzy C-Means metho d in optimizing process of summary results. The results showed that the method of Fuzzy Logic is outperformed Fuzzy C-Means method with the closest imilarity ratio to summarize manually by humans with percentage accuracy of Fuzzy Logic is 58.25% w hile Fuzzy C-Means method is 54.33%. Increased accuracy occurs when there is additional compressio n rate in the amount of 1.67% for Fuzzy Logic Metho d and 4.5% for Fuzzy C-Means.


In order to study the genetic diversity of Thamnaconus modestus, a species of great commercial importance in Southeast Asia, the 5′-end hypervariable regions (423 bp) of the mitochondrial control region of T. modestus in nine geographical populations (248 individuals) were sequenced and analysed in this study. The target sequence fragment contained large numbers of polymorphic sites (87) involved in high levels of haplotype diversity (h = 0.97 ± 0.01) and nucleotide diversity (π = 0.0285 ± 0.0143). The genetic variations within populations (92.71%) were significantly larger than those among populations (7.29%). No significant genetic divergences were detected among the wild populations owing to their gregarious habits, strong moving ability, r-selection strategy. Significant genetic divergences were found between the cultured and wild populations, probably resulting from kin selection and aquacultural environment. Three significant phylogenetic lineages were identified, and the variation among lineages (56.90%) was greater than that among individuals within the lineages (43.10%), with the significant ΦST value (ΦST = 0.57, P = 0.0000). The results showed great and significant genetic differentiations among these three lineages, indicating that they may have independent phylogenetic dynamics. Dominant shared haplotypes that included individuals from each population and the median-joining network of haplotypes presented a star-like structure. Historic demographic analysis of each lineage showed that population expansion occurred after the Pleistocene glacial period. At the last glacial maximum, T. modestus in China seas was scattered across variable refuges, including Central South China Sea and Okinawa Trough.


This paper discusses challenges to developers of a national Life Cycle Inventory (LCI) database on which to base assessment of building environmental impacts and a key to development of a fully integrated eco-design tool created for automated eco-efficiency assessment of commercial building design direct from 3D CAD. The scope of this database includes Australian and overseas processing burdens involved in acquiring, processing, transporting, fabricating, finishing and using metals, masonry, timber, glazing, ceramics, plastics, fittings, composites and coatings. Burdens are classified, calculated and reported for all flows of raw materials, fuels, energy and emissions to and from the air, soil and water associated with typical products and services in building construction, fitout and operation. The aggregated life cycle inventory data provides the capacity to generate environmental impact assessment reports based on accepted performance indicators. Practitioners can identify hot spots showing high environmental burdens of a proposed design and drill down to report on specific building components. They can compare assessments with case studies and operational estimates to assist in eco-efficient design of a building, fitout and operation.


Triple-negative breast cancer (TNBC) accounts for ∼25% of breast cancer among premenopausal African-American and Latino women1. Curcumin (diferuloylmethane; CCM), a natural polyphenol extracted from turmeric, has chemopreventive and chemotherapeutic activity in various cancers 2,3 and inhibits growth and invasion of TNBC/basal-like MDA-MB-231 human breast cancer cells 4. CCM has been reported to affect all stages of tumor progression and metastases due to its interactions with multiple targets. We employ a novel approach utilizing both computational and experimental modeling to characterize and analyze TNBC and the 3D tumor microenvironment responses to albumin bound CCM particles (ACP) versus CCM alone.© 2013 ASME


China has recently demonstrated diverse ways to pursue its economic internationalisation. The trade mechanism has been re-modelled without a heavy tone on exports and China's vulnerability to import–export risks has been steadily reduced. More than trade, the investments have been pursued to make Chinese economic expansion endure. Chinese also learned the trick of larger geo-economics by not waiting for crisis to occur and get caught in the global domino effect of slowdown, recession and other impulsive nature of markets. While, on one hand, China is trying to comply by international monetary and legal standards, making more space in a cluttered room for its economic ambitions, on the other, it is also adopting smarter ways to outperform the existing heavyweight economies' dominance in the sphere of international monetary. An example of China's sprint for maximising its legal and economic engagement and securing benefits by having bilateral currency swap agreements (BCS), exhibits how China has evolved over the last decade. A decade back, China was apprehensive about the BCS when it did not follow the Chiang Mai initiative. The current commentary attempts to analyse China's BCS strategy and the possible impact.


The utility model provides a lifting structure of a film blowing machine guide system, and aims to solve the problems that the appearance and the size of a product are difficult to control, and the quality of the product is unstable in the conventional plastic film blowing machine guide system. The lifting structure comprises two guide clamping rollers, wherein two ends of the two guide clamping rollers are fixed on two side fixed plates, and the two guide clamping rollers are parallel to each other. The lifting structure is characterized in that threaded guide rods are arranged on the outer sides and at two longitudinal ends of the two side fixed plates; threaded sliding blocks are fixed at the two longitudinal ends on the outer side wall of the two fixed plates and are in threaded connection with the threaded guide rods; transmission gears are fixed at the upper ends of the threaded guide rods; a motor capable of rotating forwards and reversely is arranged on a supporting frame on the upper parts of the two guide clamping rollers; and two output gears are arranged on the output shaft of the motor and respectively connected with transmission gears on the threaded guide rods on the outer sides and at the two longitudinal ends of the two side fixed plates through chains in a transmission manner.


Summary. A new method for the measurement of serum vitamin B12 concentration by radioisotope dilution is described in which chicken serum is used as the source of vitamin B12‐binding protein. The conditions for the assay were carefully selected on the basis of a thorough investigation of the factors affecting the critical steps in the radioisotope dilution assay for vitamin B12. The assay obeys the principle of radioisotope dilution, and gives reproducible results. The normal range for the method (400–1020 pg/ml) is higher than any previously reported normal range for a radioisotope method. Excellent discrimination was obtained between normal subjects and those with pernicious anaemia.


The paper re-examines the validity of the hysteresis hypothesis by applying it to the UK import volume from the world's five largest economies: Germany, France, Italy, Japan and the USA, over the period 1975 to 1994. Disaggregated bilateral data (4- digit ISIC) are used and hysteresis is captured by dummy variable which is an extension of work by Parsley and Wei (1993). Panel estimation is undertaken and the Seemingly Unrelated Regression (SUR) technique is employed. There is evidence that hysteresis appears important for UK imports and varies across industries and countries.


In this work, a comparative study of the microstructure and mechanical properties of Al-8Fe based bulk alloys fabricated by three different rapid solidification methods and subsequent hot extrusion was carried out. Spray forming, gas atomization, and melt spinning methods were used as techniques for rapid solidification having various cooling rates. Equiaxed grains containing Al-Fe, Al-Fe-(Mo, V), and Al-Zr phase particles were characterized. The yield strength of the melt spun and extruded specimen was estimated to approximately 800 MPa at room temperature, a value which is roughly 1.5 times higher than that obtained for the atomized and extruded specimen and roughly 2.5 times higher than for the spray formed and extruded specimen. The higher strength of the melt spun and extruded specimen originated from a finer microstructure compared to the atomized and extruded specimen and the spray formed and extruded specimen.


A new species of Melastomataceae, Brachyotum sertulatum C . Ulloa, from southern Colombia is described and illustrated. It is characterized by a conspicuous single row of large tubercles sub-marginal on the leaf blade above. It is endemic to the Paramo de las Papas in the Colombian massif (Macizo Colombiano), between the departments of Cauca and Huila at around 3400 m. Due to the restricted distribution and small population it is assigned the category of Endangered (EN).


Alcohol intoxication is known to considerably increase the probability of death from fire across the lifespan, to the extent that it has been isolated as the single most significant risk factor. The study investigated the combined effects of sleep inertia and alcohol impairment on fire emergency-relevant cognitive performance indicators in a young adult population. Mental tracking, visual scanning, psychomotor speed, working memory and sustained, selective, and divided attention functions were assessed for performance decrements and reference to speed-accuracy trade-off effects. Participants were 24 young adults (18-26 years) who participated in a repeated-measures study over 2 nonconsecutive nights; 1 night with alcohol administration and 1 'sober' night. During the alcohol administration night, 10-minute testing blocks occurred under (1) baseline sober and (2) baseline 0.05 blood alcohol concentration (BAC) conditions. Subsequently, subjects were awoken from stage 4 sleep and assessed in two consecutive 10-minute
blocks (3) and (4). Self-reports of sleepiness and clearheadedness were also taken. The same procedure was used during the sober night (with condition (2) excluded). All cognitive functions assessed showed an alcohol effect (i.e., decrements between sober baseline (1) and conditions of alcohol (2)), and an even larger sleep inertia effect (i.e., greater decrements between sober baseline (1) and conditions of sleep inertia alone (3) and (4)). Sleep inertia selectively affected performance speed on the working memory task, whilst performance accuracy on this task was affected by conditions of alcohol impairment only. When the sober and alcohol nights were compared, there was no combined or synergistic interaction between sleep inertia and alcohol impairment on the cognitive tasks or subjective measures during the first 10 minutes of sleep inertia.
Conditions of combined sleep inertia and alcohol impairment produced cognitiveperformance decrements that were greater than those produced by alcohol administrationalone, but not those produced by sleep inertia alone. Indeed, sleep inertia effectsappeared to 'override' alcohol effects. At 10-20 minutes post-awakening, however, sleepinertia effects began to dissipate, thus 'unmasking' alcohol effects on some tasks,including accuracy of working memory performance, selective/sustained attention and subjective sleepiness. Divided attention performance demonstrated a complex and unpredictable pattern at 10-20 minutes post-awakening whereby performance under conditions of sleep inertia and alcohol intoxication combined became significantly worse than either condition alone, indicating that alcohol effects were also possibly being unmasked for this measure. Other measures (speed of working memory performance and subjective clearheadedness) showed no difference between conditions at 10-20 minutes post-awakening. The results suggest that (1) moderate alcohol impairment and sleep inertia do not combine to produce further decrements in neurocognitive functioning than
those caused by the effects of alcohol or sleep inertia alone and (2) sleep inertia poses a greater risk to fire emergency escape than moderate alcohol impairment. Moreover this data suggests that when awoken abruptly in an emergency situation, prior alcohol consumption to 0.05 BAC will not further impede cognitive functioning that is already compromised by a state of sleep inertia. The study considers the importance of the arousing effects of task complexity, the BAC curve (particularly the descending limb), and speed-accuracy trade-off effects in predicting the effects of sleep inertia and alcohol on cognitive performance.


The existence of two species of molybdophosphate has been recognized in aqueous acetonitrile solutions. The one, which was called here as "extraordinary" molybdophosphate, forms quite rapidly and exhibits a bright yellow colour, but is unstable and undergoes a spontaneous conversion to the other. The latter complex would be of dodecamolybdophosphate in Keggin's structure.


ABSTRACT Content and language integrated learning (CLIL) aims to unify linguistic and extra-linguistic goals. However, as research indicates [e.g. Lyster 2007. Learning and Teaching Languages through Content. A Counterbalanced Approach. Amsterdam: John Benjamins], it is still searching for an optimal balance between linguistic and content gains as learners do not, typically, demonstrate productive grammar skills on a par with their content knowledge, lexical repertoire and receptive skills [Tedick and Cammarata 2012. "Content and Language Integration in K-12 Contexts: Student Outcomes, Teacher Practices, and Stakeholder Perspectives." Foreign Language Annals 45 (S1): S28–S53. doi:10.111/j.1944-9720.2012.01178.x.]. The aim of the paper is to outline a possible solution to the problem by proposing content-based structured input (CBSI) as a means of balancing linguistic and extra-linguistic gains in CLIL. As hypothesized, CLIL may lead to the processing of both content and form, provided that input is structured in such a way that subject matter becomes accessible to the learner only through the analysis of the target language structure. As assumed, this should reinforce the positive effects found for structured input [e.g. VanPatten 2015a. "Foundations of Processing Instruction." International Review of Applied Linguistics 53 (2): 91–109. doi:10.1515/iral-2015-0005] with those observed for content learning [e.g. Dalton-Puffer 2007. Discourse in Content and Language Integrated Learning (CLIL) Classrooms. Amsterdam: John Benjamins] and, in consequence, effect long-term changes in learners' underlying linguistic systems. The theoretical discussion is supported by the results of a quasi-experimental study carried out among 41 adult L1 Polish learners of English, which compared the effectiveness of CBSI to comprehension-based instruction in the context of CLIL.


To review if the existing data support the new concept that antimuscarinic agents can be used for the treatment of bladder outlet obstruction (BOO) with coexisting overactive bladder (OAB).


The effect of blockage of costimulatory signal on the expressions of cytokine TGFβ,and matrix metalloprotein- ase-9(MMP-9),tissue inhibitor of metalloproteinase-3(TIMP-3),plasminogen activator inhibitor-1(PAI-1)and outcome of pregancy in abortion-prone model of mice was investigated by using CBA/J×DBA/2 matings as the abortion-model and CBA/J×BALB/c matings as the normal pregnancy model.This investigation was performed in three groups of mice,in which the a- bortion-prone models consisted of experimental and control experimental groups as well as the normal pregnancy group.In the experimental group and the control experimental group,100μg of rat anti-mouse monoclonal antibodiy against CD86 molecule in 200μ1 PBS or the irrelevant isotype matched rat IgG2b were injected intraperitoneally to pregnant CBA/J mice on day 4.5 of gestation,respectively.As for the normal pregnancy group,nothing was given to mice.On day 13.5 of gestation,all the pregnant CBA/J mice were sacrified and the embryo resorption rates were calculated,and the immunohistochemical methods were used to detect the expressions of TGF-β,MMP-9,TIMP-3 and PAI-1 proteins.It was demonstrated that the embryo re- sorption rate in the experimental group was significantly reduced in comparison with that in the control experimental group(x~2 =7.441,P=0.006),yet with no significant difference with that in the normal pregnant group(x~2=0.016,P0.05). Meanwhile,compared with the control experimental group,the expressions of TGF-βand PAI-1 in the experimental group was significantly increased(P=0.010;P=0.003 respectively),also showing no signficant difference with the normal pregnan- cy group(P=0.500).In addition,the expression of MMP-9 in the experimental group was significantly reduced in compari- sion with that of the control experimental group (P=0.012),still showing no significant difference with the normal pregnancy group(P=0.500).However,the expression of TIMP-3 in the experimental group showed no significant difference with that of the control experimental group (P=0.328)and that of normal pregnancy group (P=0.500)respectively.It is concluded from the above observations that the blockage of the costimulatory signal induced by CD86 at early stage of gestion renders TGF-β,MMP-9,TIMP-3 and PAI-1 to exert their immuno-tolorent effects through different mechanisms and can reduce the embryo resorption rate to the level of normal pregnancy.


Spaceborne Synthetic Aperture Radar (SAR) has attracted special interests in many applications, but suffers from image quality degradation caused by azimuth ambiguities. To suppress this phenomenon, different from conventional suppression method, this paper concentrates on the analysis of precise mathematic expression of azimuth ambiguities. Exploiting the specific characteristic of ambiguities, a restoration algorithm to suppress azimuth ambiguities of stripmap SAR is proposed. This method is not sensitive to SNR, and also suitable for distributed targets. Azimuth ambiguities are accurately restored and then cancelled in SAR image. Proposed method has been shown effective by experiments, demonstrating capabilities of removing artifacts and revealing covered targets in stripmap SAR image.


The present text discusses the problems concerning the translation and the non-translation of the thinking word Dasein in Sein und Zeit. Assuming that for Heidegger Dasein is transcendence and this ...


Article History: Received: 20 Nov 2016 Accepted: 03 Mar 2017 Available Online: 01 Jan 2018 Bullet Points: • Oral steroid after IV methylprednisolone improves color vision in short term. • Oral steroid after IV methylprednisolone does not have effect on visual acuity in short term. Citation: Mohammadianinejad SE, Majidinasab N, Nejati A, Mehramiri A, Sajedi SA, Hesam S, Hatamian H. Tapering Oral Steroid Treatment After IV Methylprednisolone Pulse Therapy in Demyelinating Optic Neuritis. Caspian J Neurol Sci. 2018; 4(1):1-5. https://doi.org/10.29252/NIRP.CJNS.4.12.1 Running Title: Oral Steroid After IV Methylprednisolone in Optic Neuritis : https://doi.org/10.29252/NIRP.CJNS.4.12.1 Use your device to scan and read the article online Caspian Journal of Neurological Sciences "Caspian J Neurol Sci" Journal Homepage: http://cjns.gums.ac.ir


State Aid: Main developments between 1 September and 31 December 2010* On 8 November 2010 the Commission authorised aid for the restructuring of CajaSur. CajaSur provided retail banking…


The fluorescence properties of 4-aminophthalimide derivatives are influenced by the side-chain attached to the paramagnetic ring or its diamagnetic precursor. PET (photoinduced electron transfer)-induced fluorescence enhancement in the presence of Fe3+ ions was observed only in the case of diamagnetic basic side chain derivatives, since transient metal ions are present in biological systems, only double sensors lacking the above sensitivity are considered as potential reactive oxygen probes.


Cellular senescence is a mechanism by which a cell enters stable cell cycle arrest triggered by various types of stress such as telomere shortening, oxidative stress and DNA damage. It is implicated in a number of pathophysiological conditions including age-related diseases, degenerative disorders and cancer. Despite its importance, the current toolbox for studying or monitoring senescence in vivo is limited. We have developed a series of novel near-infrared (NIR) fluorescent probes that can be activated by senescence-associated β-galactosidase (SA-β-Gal) and self-immobilize onto intracellular proteins via in situ labeling. We compared the labeling efficiency of these probes in vitro and in cells and the results shows that by modulating the leaving group, we can improve the labeling efficiency of the probes and enhance their retention at the site of activation. These probes can be used for imaging of senescence developed in live cells, as well as long-term tracking of senescent cells in various animal models.
 Citation Format: Zixin Chen, Yuzhao Zhang, Seyedehalaleh Anvar, Chang-hung Wu, Jun Liu, Joyce Z. Jiang, Lina Cui. NIR fluorescent probes for senescence imaging via tunable in situ labeling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 138.


I spent my days as a high school student at a time when the "Gang of Four" were running amuck and therefore learned very little. In the current march toward the four modernizations, I feel I am handicapped by lack of knowledge and must rouse myself to catch up. So I make use of every bit of time to pursue my studies. During work breaks when others get together for a chat, I step aside and take out my book to read a few pages. When waiting for the bus at a bus stop, I take out my notebook and try to memorize a few English words. In the after-work hours when others go shopping or watch movies, I lock myself in reading. Sometimes during meetings people just indulge in idle talk. I feel it's a waste of time and sit by myself and read. In principle, my craving for study is a good thing, but I cannot find support. Some even accuse me of lacking a concern for the collective, that I am bent on outstripping my peers and engaged in individual struggle. I find it hard to vindicate myself, and I feel under great pres...


Two-photon-absorption spectra of Si, ZnSe, and GaAs are evaluated in a wide photon-energy range by using ab initio full-band-structure and microscopic-nonlinear-susceptibility calculations. It is shown that Si and ZnSe have abundant spectral structures originating from the transitions at both the center and boundary of the Brillouin zone, being in good agreement with recent experimental results. The calculated spectra are analyzed by comparing with those of one-photon absorption and the scaling formula.


One difficulty faced by students on many information management courses is the lack of any attempt to teach concepts of information. Therefore, if a core module does not fit in with a student's existing concept of information, it can make it hard for the student to recognise the relevance of that module. This paper addresses that problem by summarising concepts of information, and by presenting a simple model that attempts to unite the various concepts listed. The model is based on the idea that the meaning in a message depends on the context in which the message originated (the authorial context), and the context in which it is interpreted (the readership context). Characteristics of authors, readers and messages are discussed. The impact of the 'knowledge' of 'information' users, and of their community, is considered. Implications of the model are discussed. A definition of information is suggested, which attempts to encapsulate the nature of information implied by the model.


Background In young patients with femoral neck non-union it is desirable to preserve the femoral head. The objective of this study was to assess the outcome results of revision internal fixation and nonvascular fibular bone grafting Patients and Methods: Ten patients with non united fracture neck femur were included in this prospective study. Fixation was done with two cancellous screws leaving behind a space between two screws for fibular strut graft. Assessment of union was done by both clinical and radiological criteria. Results: union was achieved in 8 cases in an average time of 16 weeks (range 12–20 weeks). There was no infection, thromboembolic complications, donor site morbidity or implant failure in our series. Conclusion: Nonvascularized fibular strut graft along with cancellous screws provides a biological and mechanically sound method of treatment. Fibula being cortical provides mechanical strength besides stimulating union and getting incorporated as biological graft.


FIELD: chemistry. SUBSTANCE: invention relates to a novel method of producing a sodium salt of 1-[[[(R)-M-[(E)-2-(7-chloro-2-quinolyl)vinyl]-alpha-[O-(1-hydroxy-1-methylethyl)phenetyl]benzyl]thio]methyl]cyclopropane acetic acid (Montelukast sodium), which involves the following steps: a) reaction of 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol with methane sulphonyl chloride in the presence of a tertiary amine, b) filtering the crude solution of methane sulphonate 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol obtained at step a) from solid amine hydrochloride and direct reaction with a disodium salt of 1-(mercaptomethyl)cyclopropane acetic, c) extraction of 1-[[[(R)-M-[(E)-2-(7-chloro-2-quinolyl)vinyl]-alpha-[O-(1-hydroxy-1- methyethyl)phenetyl]benzyl]thio]methyl]cyclopropane acetic acid from the reaction mixture obtained at step b) in form of a toluene solution. That solution is then treated with tert-butylamine, thereby obtaining tert-butylamine salt of 1-[[[(R)-M-[(E)-2-(7-chloro-2-quinolyl)vinyl]-alpha-[O-(1-hydroxy-1-methylethyl)phenetyl]benzyl]thio]methyl]cyclopropane acetic acid in crystalline form, d) extraction and purification of the salt obtained at step c), e) turning the salt obtained at step d) into an amorphous sodium salt of 1-[[[(R)-M-[(E)-2-(7-chloro-2-quinolyl)vinyl]-alpha-[O-(1-hydroxy-1-methylethyl)phenetyl]benzyl]thio]methyl]cyclopropane acetic acid. EFFECT: novel method of producing Montelukast sodium, characterised by considerable simplification of the production process. 4 cl, 5 dwg, 2 ex


Huihu is ancestor of present Uyghur.At 840A.D.,Huihu Khanate,who reigned mongolia tableland for nearly one century,were overthrown in the internal disorder and foreign invasions.Most of the remaining people moved to the West region and Central Asia.Adapted to the local environment and high-developed agricultural civilization,Huihu transformed to a agrarian people of distinctive characteristics from a nomads mainly living on stock raising.The successful transformation of Huihu had far-reaching impacts on the formation of modern Uygur and the development of Xinjiang history.


BACKGROUND: HIV status may affect outcomes after definitive chemoradiotherapy for anal cancer. OBJECTIVE: Here, we report a large series in the highly active antiretroviral therapy era comparing outcomes between HIV-positive and HIV-negative patients with anal cancer. DESIGN: This was a retrospective chart review. SETTINGS: The study was conducted at an outpatient oncology clinic at large academic center. PATIENTS: A total of 107 patients were reviewed, 39 HIV positive and 68 HIV negative. All of the patients underwent definitive chemoradiation for anal cancer. MAIN OUTCOME MEASURES: Data on patient characteristics, treatment, toxicity, and outcomes were collected. Overall survival, colostomy-free survival, local recurrence-free survival, and distant metastasis-free survival were analyzed. RESULTS: Median follow-up was 15 months. HIV-positive patients were younger (median, 52 vs 64 years; p < 0.001) and predominantly men (82% men vs 49% men; p = 0.001). There were no significant differences in T, N, or stage groups. HIV-positive patients had a significantly longer duration from biopsy to start of chemoradiation (mean number of days, 82 vs 54; p = 0.042). There were no differences in rates of acute toxicities including diarrhea, fatigue, or dermatitis. HIV-positive patients had significantly higher rates of hospitalization (33% vs 15%; p = 0.024). The 3-year overall survival rate was 42% in HIV-positive and 76% in HIV-negative patients (p = 0.037; HR, 2.335 (95% CI, 1.032–5.283)). Three-year colostomy-free survival was 67% in HIV-positive and 88% in HIV-negative patients (p = 0.036; HR, 3.231 (95% CI, 1.014–10.299)). Differences in overall survival rates were not significant on multivariate analysis. LIMITATIONS: This study was limited by its retrospective design and small patient numbers. CONCLUSIONS: In this cohort, HIV-positive patients had significantly worse overall and colostomy-free survival rates than HIV-negative patients. However, differences in survival were not significant on multivariate analysis. Additional studies are necessary to establish the etiology of this difference.


Abstract 4090

Leukemic stem cells (LSC) are believed to be responsible for disease maintenance and/or propagation. A hallmark example is chronic myelogenous leukemia (CML). CML is a lethal malignancy that results from hematopoietic stem cell (HSC) transformation by the oncogene BCR-ABL. BCR-ABL tyrosine kinase inhibitors (TKI) are highly effective drugs to induce disease remission in CML patients and prolong their survival, but do not eliminate the LSC population and are required to be maintained throughout the patient's life to prevent relapse. Therefore, there is a strong rationale to develop strategies to target residual LSC to enable cessation of TKI treatment without leukemia relapse. Growing evidence indicates that signals from the bone marrow (BM) microenvironment are crucial for the maintenance of LSC and it has been suggested that LSC and HSC may locate in different niches where distinct microenvironment generated signals arise. We have previously demonstrated that Connexin-43 (Cx43) regulates HSC activity by preventing chemotherapy-induced senescence/apoptosis by allowing stromal-mediated ROS scavenging (Taniguchi-Ishikawa E et al., PNAS 2012), and allows homing/engraftment of HSC through stromal mediated trans-stromal migration (Gonzalez-Nieto D et al., Blood 2012). Here, we analyzed whether the microenvironment Cx43 function is required for BCR-ABL LSC maintenance or BCR-ABL LSC are independent of microenvironment Cx43-mediated signals. For this purpose, we utilized binary transgenic mice which express p210-BCR-ABL driven by inducible (Tet-off) expression of Scl in HSC. An enriched fraction of LSC (1,000 Lin−/c-kit+/Sca1+ cells) from Dox-off Scl-tTA × TRE-BCR-ABL (SclTg) mice (CD45.2+) was competitively transplanted with 3×106 CD45.1+ BM cells as previously described by our group (Sengupta A et al., Blood 2010 & Blood 2012) into lethally-irradiated Col1α1-WT (OB/P WT) or Col1α1-Cx43f/f (OB/P Cx43Δ/Δ) mice. HSC/P BM chimera was analyzed at 18 weeks post-transplantation by measuring the BM content of CD45.2+ BM cells, CD45.2+ Lin−/c-kit+/Sca1+ (HSC/multipotential progenitors) and CD45.2+ Lin−/c-kit+/Sca1− (progenitors) BM cells. Chimera of equivalent CD45.1+ populations was used as an internal control of normal HSC engraftment. Interestingly, the content of CD45.2+ or CD45.1+ Lin−/c-kit+/Sca1+ was not significantly modified by the deficiency of Cx43 in the osteolineage microenvironment (average ∼ 0.50% of BM cellularity). However, the content of progenitors from SclTg mice was ∼85% decreased in OB/P Cx43Δ/Δ mice while the content of competitor progenitors was also decreased albeit at a lower level (∼30% reduction), indicating that the hematopoietic ability of LSC and HSC were significantly impaired by the deficiency of Cx43 in the osteolineage microenvironment. To determine whether this defect was exclusively dependent on osteolineage deficient BM stroma, we performed long-term BM cultures of Scl-tTA × TRE-BCR-ABL (or non-Tg control from littermates) LSK cells onto WT or Cx43-deficient irradiated stroma obtained from OB/P Cx43Δ/Δ mice (Gonzalez-Nieto D et al., Blood 2012). At the end of 4 weeks of culture, we observed an average reduction in the number of CFUs of 84% (vs 86% for Non-Tg control HSC) when LSC were cultured on OB/P Cx43-deficient stroma. Altogether, these data indicate that the osteolineage deficiency of Cx43 impairs the hematopoietic activity of both LSC and HSC. BCR-ABL activity in LSC does not confer independence of Cx43-mediated signals from the BM osteolineage microenvironment.

Disclosures: No relevant conflicts of interest to declare.


A self-assembly driven dynamic peptide based nanostructured library is made using a reversible chemical fuel-catalyzed reaction. The reaction between peptide based bolaamphiphiles and dimethyl sulphate facilitates the formation of a predominant nanostructured product in a gel phase medium. The resultant product self-assembles into well-defined β-sheets which further self-assemble into hierarchical nanofibrils.


Let p and q be odd primes with p = 2q + 1. We study the number of solutions of congruence equations ax i + by j · c (mod p) and ax i + by j + dz t · c (mod p)


Who wants to have rigs delayed or even lose a well in 4000 ft of water because of tophole drilling problems? Or find out after drilling a deepwater discovery well that site conditions will make development unexpectedly expensive or economically unfeasible altogether? Or learn late in the exploration development sequence that the cost of an export pipeline will be significantly more expensive than originally budgeted because of difficult route conditions?


This parer describes an optical contour method of displaying a surface by interference between two laser beams; one reflected by a grating placed over a test surface without contact and the other transmitted through the grating and reflected by the test surface. An optical filtering technique was applied to vary the measuring sensitivity by selecting the diffraction order, from several micrometers to several tens of micrometers. Discussions on the surface conditions of samples and the grating profiles needed to obtain clear contour fringes are presented. This technique can be applied to the study of the fracture toughness of metals.


In this research, the effects of the gravel content on the liquefaction behavior for both of the isotropically and consolidated gravel-sand mixtures are investigated. for this purpose, the cyclic triaxial tests for the specimens with the same relative density (Dr=40%) and variations of gravel content were performed. On the other hand, a series of undrained cyclic triaxial tests were carried out on the isotropically consolidated gravel-sand mixtures with the same void ratio (e=0.7) and from 0% to 30% gravel contents. Void ratios of gravel-sand mixtures with the same relative density (Dr=40%) are found to decrease significantly with the increase of the gravel content from 0% to about 70% and increase thereafter. But the void ratio of the sand matrix among the gravel skeleton increases with the increase of the gravel contents. Test results are as follows : for the isotropically consolidated specimen with 40% of relative density and low gavel contents (GC=0%, 20%, 40%), pore water pressure development and axial strain behavior during undrained cyclic loading show similar behavior to those of the loose sand because of high void ratio, and the specimens with high gravel content (70%) both pore pressure and strata behaviors are similar to those of dense sand. And the isotropically consolidated specimens with the same void ratio (e=0.7) and higher gravel contents show the same behavior of pore water pressure and axial strain as that of the loose sand, but for the lower gravel content this behavior shows similar behavior to that of dense sand. The liquefaction strength of the isotropically consolidated specimens with the same relative density increases with gravel content up to 70%, and the strength decreases with the increase of the gravel content at the same void ratio. Thus, it is confirmed that the liquefaction strength of the gravel-sand mixtures depends both on relative density and void ratio of the whole mixture rather than the relative density of the sand matrix filled among gravels. On the other hand, the behavior of pore water pressure and axial strain for the consolidated gravel-sand mixtures shows almost the same cyclic behavior of the sand with no stress reversal even with some stress reversal of the cyclic loading. Namely, even the stress reversal of about 10% of cyclic stress amplitude, the permanent strain with small cyclic strain increases rapidly with the number of cycles, and the initial liquefaction does not occur always with less than maximum pore water pressure ratio of 1.0. The liquefaction resistance increases with the gravel contents between 0% and 40%, but tends to decrease beyond 40% of gravel content. In conclusion, the cyclic behavior of gravel-sand mixtures depends on factors such as gravel content, void ratio, relative density and consolidation condition.


The extent and persistence of practice effects on serial performance in the Farnsworth‐Munsell 100‐Hue test (100‐Hue test) were evaluated in an experiment in which six subjects performed the 100‐Hue lest up to 17 times over six weeks, and then once more after 7 months. A practice effect occurred which was highly statistically significant for the group as a whole (P < 0.001) and for three individual subjects (P < 0.05). A practice effect was still evident 7 months after the last test performance. Error scores were reduced almost to zero after 5–10 retests so that it was unclear whether the effects of practice had disappeared or whether failure to improve further was a 'floor effect'. As a control against a floor effect, a second experiment was performed in which subjects'performance was impaired by placing neutral density filters in from of their eyes (thus artificially raising their 100‐Hue error score) Under these conditions, error scores continued to fall and were halved after 17 tests (P < 0.03). It is concluded that practice has a large effect on 100‐Hue test performance which continues over many retests and for many months after testing.


The processes that are developed in the gastronomic field in the Restaurant of the ESPOCH Gastronomy Career are carried out efficiently, so it is pertinent to make the polytechnic community known and socialize the general public through different communication processes as performs solid waste management which will improve the service provided by students and teachers in the environment in the aforementioned restaurant. It is important to disseminate how practices are carried out in terms of solid waste management, identifying the need to implement adequate environmental plans that facilitate and improve restaurant services, in this way both environmental and visual impacts can be greatly reduced. that could be generated by the accumulation of garbage. To carry out this research, a diagnosis was first made and then a baseline survey on the management of both organic and inorganic solid waste resulting from the process generated in the kitchen, and the processes that are developed in terms of recycling were identified. Within the course, through some research techniques such as observation, application of surveys, and interviews with both the responsible staff and users of the ESPOCH School of Gastronomy restaurant, Additionally, an environmental file was used to identify the characterization of areas of influence in both the physical, biotic, socio-cultural, and educational areas, among others. The Environmental Standards TULAS BOOK VI Annex 6 for the Management of Non-Hazardous Solid Waste have also been consulted , and the Per Capita Production of waste that the restaurant generates has been determined, being 0.20 Kg / Room / day. o 0.45lb / Hab / day and a total of waste generated per week of 113.91Kg. or 250.61lb corresponding to a common week of work in the restaurant.


Australia's mental health system is failing young people. Calls for accountability, strategic long-term policy planning, and regional leadership have been identified as solutions to guide mental health reform. Developing system dynamics models using a participatory approach (participatory systems modelling (PSM)) is recognized as a useful method that can support decision-making for strategic reform. This paper reports evaluation findings of a youth mental health PSM process conducted in the Australian Capital Territory (ACT). Baseline and follow-up mixed-methods evaluation data were collected in 2022 across diverse stakeholder groups to investigate the feasibility, value, impact, and sustainability of PSM. Although youth mental health system reform was viewed as desirable and a necessity across all stakeholder groups, shared perceptions of disabling powerless was observed regarding their ability to influence current decision-making processes to improve the youth mental health system. This suggests greater accountability is required to support systemic reform in youth mental health. PSM offers promise in improving transparency and accountability of decision-making for youth mental health, as exemplified in the ACT. However, more support and time are required to facilitate transformational change. Future research should investigate empowerment strategies to complement the implementation of findings from dynamic models developed through PSM, as well as the effectiveness of regional youth mental health policy decision-making supported by systems modelling.


Food and Drink Development of Appetite for Food and Drink Physiological Influences on Appetite The Soul of the Diet Design of Beverages and Food Products The Heart of the Diet Dieting Neuroscience of Ingestive Appetite Psychology and the Sciences of Food and Health.


Lazy learning has shown promising reliability in data stream classification mining, which suffer from 'Curse of dimensionality' in broad applications. Conventional Attribute selection methods always seek promising subspace by ranking all the attributes, which is not suitable for lazy learning, and suffer from high computing complexity. We proposed a novel attributes selection method 'DistinGuishing Subspace (DG-Subspace)', which lay high values on the performance of attributes as a group instead of single attribute with higher ranks. 'DistinGuishing Pattern Tree (DGP-tree)' was formed to compress dataset, based on which a heuristic method to seek DG-subspace was raised, with linear scalability. Theoretic analysis and numeric experiment justified the effectiveness and efficiency of the method.


Relationship between Pediatric Wheezing Attack Frequency and Sugarcane Harvest Work: Prospective Cohort Study Abstract Introduction : Our aim was to determine the relationship between pediatric wheezing attacks and sugarcane harvest work. Methods : We recorded daily symptoms, including wheezing attacks, from 167 children attending kindergar-ten, elementary and junior high school on Minamidaito Island, Okinawa. We calculated wheezing attack frequency every two months and checked the seasonal changes. Logistic regressions were performed to examine the relationship between wheezing attacks and background factors. Result : The collection rate of the check sheets was 62.5%. The median age was 7.5 years old, male-to-female ra-tio was 8:7 and the percentage of children with asthma was 36%. Wheezing attack frequency during sugarcane harvest work (January-March) had increased significantly compared with other periods. There was a number of wheezing attacks even in children without asthma. Conclusion : There is a possibility that sugarcane harvest work is related with pediatric wheezing attacks.


This paper presents the analysis of the operational performance of a PV inverter with added active filter (AF) functionalities. The paper details modelling of a PV inverter acting as an AF and performing compensation of fundamental reactive power and non-fundamental distortion power, i.e. compensation of harmonic emission due to nonlinear loads connected in the local network. Several load cases are analysed, including emission by constant harmonic current sources and full-wave rectifier loads, which are also considered for different operating powers.


Classical Islamic law in terms of assigning legal rules, inter alia, explicitly recognizes four genders among human beings, namely male, female, hermaphrodite, and effeminate male. In this context, the body of rules that regulate male and female behaviors is regarded as normative. Hermaphrodite upon birth are left in limbo until they can be absorbed into any one of the binary gender system upon puberty or else would be regarded as problematic. Effeminate male/transsexuals on the other hand, are expected to contain their psycho-pseudo female tendencies by not becoming erotic. With the advances in the field of medicine, psychology and sociology, the classical fiqhi postulates on transsexuals have been challenged on several grounds including the legitimacy of attempts by transsexuals for sex reassignment. Vast majority of the contemporary Sunni


The present paper is about the comparative structures of subjunctive mood sentences with Russian and Chinese. It depicts how these forms of sentences can express the speaker's attitude towards his/her willing to ask or to wish something. Moreover, it discusses language units, prefixes/affixes, and many other from linguistic and social point of view.


Decisions of the U.S. Supreme Court can have a huge impact on the healthcare industry. This year is no different.


A CUTE GASTROENTERITIS (GE) IS A COMMON childhoodillness. Althoughchildrenwith GEfrequentlyhavevomiting, current practice recommendations for pediatric GE do not include pharmacologic treatment for vomiting. Furthermore, experimental studies of medications to treat pediatric GE-associated vomiting are limited. In this issue of the Archives, DeCamp et al performed a systematic review and meta-analysis to determine if antiemetic treatment reduces vomiting and decreases the need for further intervention in children with GE. Two assessment tools were used to determine the quality rating of each article. The primary outcome measures included cessation of emesis, use of intravenous fluid (IVF) for rehydration, hospital admission, return to care, and medication adverse effects. Using computerized databases, references lists, and expert recommendations, DeCamp et al identified 11 prospective controlled studies that met inclusion criteria. The


Copper-doped nickel hydroxide (Cu:Ni(OH)2) was synthesized via a facile wet-chemical method and its structural and electrochemical properties were compared to those of pure nickel hydroxide (Ni(OH)2). After Cu incorporation, the morphology of the Ni(OH)2 nanostructures could be easily tuned from a curved nanolayered structure to a nanolayer-stacking structure. Both samples were hydrophilic. Furthermore, even though no additional conductive and binder materials were employed, the Cu:Ni(OH)2 sample exhibited better pseudocapacitance performance than the Ni(OH)2 sample. These results confirmed that the Cu:Ni(OH)2 sample, which can be prepared by an easy low-cost method, shows great potential for application in electrochemical devices.


The detection of crack information is very important in mural conservation. In practice, the number of ancient murals is scarce, and the difficulty of collecting digital information about murals leads to minimal data being collected. Crack information appears in pictures of paintings, which resembles painting traces and is easy to misidentify. However, the current mainstream semantic segmentation networks directly use the features of the backbone network for prediction, which do not fully use the features at different scales and ignore the differences between the decoder and encoder features. This paper proposes a new U-shaped convolutional neural network with feature pyramids and a transformer called TMCrack-net. Instead of U-Net's jump-join, an AG-BiFPN network is used, which consists of two modules: a channel cross-fusion (CCT) module with a transformer and a bidirectional feature pyramid network. While fully using the information in different network dimensions, the channel cross-fusion module optimizes the final features of each layer to reduce the confounding effect caused by the fusion of features. For the fusion of multi-scale channel information with decoder features, we designed a fusion module based on a channel attention (called FCA) to guide the fusion of enhanced encoder features with decoder features and reduce the ambiguity between the two feature sets. To demonstrate the effectiveness and generalization of the model, TMCrack-Net was evaluated on the Tang Dynasty tomb chamber mural dataset and Crack500. MIoU values of 0.7731 and 0.7944 were achieved, respectively, which are better than those of other advanced crack detection methods. The method yields accurate segmentation performance and is advantageous for mural painting crack segmentation tasks.


Based on the ongoing disclosure overload debate, this paper investigates how deregulation-driven decreases in quarterly disclosure affect information asymmetry. We exploit a German setting in which the minimum content requirements for quarterly reporting have been reduced for firms listed in the Prime Standard segment of the Frankfurt Stock Exchange (FSE). This deregulation allows Prime Standard companies to choose whether to continue to publish full quarterly financial reports or to switch to so-called quarterly statements to meet their quarterly reporting obligations. Compared to full quarterly reports, the latter have significantly lower minimum content requirements. Based on a difference-in-differences research design, our results provide empirical evidence that decreases in quarterly disclosure come along with statistically and economically significant increases in information asymmetry. However, we find that this effect is particularly driven by smaller firms, which operate in weaker information environments. Additionally, our results confirm that this information asymmetry effect is associated with the extent of actual decreases in (specific content-related types of) quarterly disclosure.


Jimmy Carter may be the most successful and celebrated former president in American history (though John Quincy Adam's recent appearance in Amistad may give Carter a brief chase). Yet, Carter was all but hounded out of office in 1980, denounced for a disastrous domestic economic policy and a vacillating and ineffective foreign policy. Has Carter simply improved with age (and declining official responsibilities)? Or have we rushed to judgment and condemned Carter's term in the White House unfairly? It has been argued that the Carter administration's "sheer level and range of activity, if not the results, suggested a foreign policy equivalent of FDR's New Deal" (p. xii, quoting Gaddis Smith). This bold foreign policy agenda had been abandoned, however, by the end of Carter's single term in office. David Skidmore argues that the traditional realist view cannot fully explain this reversal of course. Carter did not naively underestimate the threats facing the United States in the late 1970s. Quite the contrary, Carter understood that the real threat would be a refusal to adjust and reconfigure America's commitments in the post-Vietnam era. Nor was it the case, Skidmore maintains, that Carter's foreign policy was incoherent and ineffective. There were important successes (Camp David, the forging of normal relations with the People's Republic of China, the transition to majority rule in Zimbabwe, the negotiation of the Panama Canal treaty, and the negotiation of SALT II were among them), and it was a policy that was intentionally flexible, nonideological, and responsive.


The near-conservation of energy on long time intervals in numerical discretizations of Hamiltonian partial differential equations is discussed using the cubic nonlinear Schrodinger equation and its discretization by the split-step Fourier method as a model problem.


A high performance electrochemical DNA sensor with three-dimensional graphene (3DGR) and gold (Au) nanocomposite modified electrode was developed for sensitive analysis of specific hly gene of Listeria monocytogenes. Nanocomposite was synthesized by electrochemical deposition of 3DGR and Au in turn on carbon ionic liquid electrode (CILE). Mercaptoacetic acid (MAA) was self-assembled on Au/3DGR/CILE by the specific binding of Au-S bond, which was used for the covalently linkage of ssDNA probe sequences. The fabricated ssDNA/MAA/Au/3DGR/CILE could interact with the target ssDNA sequence and the hybridization was recorded by using electrochemical indicator methylene blue (MB). Based on the reduction current of MB, this electrochemical DNA sensor was able to detect the target ssDNA sequence of hly gene with a wide linear concentration range (1.0×10 -14 to 1.0×10 -6


We discuss an interferometric scheme employing interference of bright solitons formed as specific bound states of attracting bosons on a lattice. We revisit the proposal of Castin and Weiss [Phys. Rev. Lett. vol. 102, 010403 (2009)] for using the scattering of a quantum matter-wave soliton on a barrier in order to create a coherent superposition state of the soliton being entirely to the left of the barrier and being entirely to the right of the barrier. In that proposal, it was assumed that the scattering is perfectly elastic, i.e. that the center-of-mass kinetic energy of the soliton is lower than the chemical potential of the soliton. Here we relax this assumption: By employing a combination of Bethe ansatz and DMRG-based analysis of the dynamics of the appropriate many-body system, we find that the interferometric fringes persist even when the center-of-mass kinetic energy of the soliton is above the energy needed for its complete dissociation into constituent atoms.


Based on a large dataset in travel Q&A website, this paper is aimed to investigate the effects of online respondent' gender on the questioners' decisions of best answer adoption. After controlling some other variables relating to the characteristics of both questions and questioners, the results indicated that if the questions are answered by female responders, the effect of their responding experience on the possibility of their answers to be identified as best answer increases significantly. Further, if it is the females who answering, the effect of time intervals between questions and answers increase as well. However, when it comes to the content length, the moderating effect is insignificant. According to our results, some efficient and effective selection methods of travel information are provided that could be the reference for the online travel website to select best-answers. Finally, the implications of the results are discussed in relation to research and practice.


An innovative rolling-horizon production/ inventory (PI) production management and control system is proposed. A multiobjective genetic algorithm (MGA) approach is designed as a solution to the production planning problem in this system. Simulations demonstrate this system is a noted improvement to any of existing techniques, and also in practice, provides a new trend of integrating the manufacturing resource planning (MRP-II) and just-in-time(JIT) together.


This article presents a review of the concepts of social innovation, design for social innovation, traditional services, service design and relational service design with the aim of analyzing the collective Agroecologia na Periferia, that acts as an agroecological technical consultancy in the city of Belo Horizonte and its metropolitan region. As a result, we obtained a practical understanding of the concepts previously presented and also the difference between the perspective of traditional services and relational services in the performance of the collective.


This study intends to improve students' proof ability in abstract algebra course based on teaching and learning through APOS theory approach and to know level of students understanding in abstract algebra. This research is pre-experiment one shot case study design. The sample were the students who participating in the abstract algebra course academic year 2018/2019 at Andalas University. Instrument used in this study was test of proof ability which consisted of three proof test, that measures the ability of proof construction. Level of students' ability in proofs are grouped into three categories, namely: level 1 (sintactic), level 2 (concrete semantics), and level 3 (abstract semantics). The results showed that: (1) 30% of students achieved level 3, 50% of students achieved level 2, 14% of students achieved level 1, 3% of students achieved level 0 and 3% excluding the category of level 0, level 1, level 2, and level 3. (2) Most of student have difficulty in learning Abstract Algebra, (3) The students trained with teaching and learning based on APOS theory approach had the mean score of the ability to proof different from 45.00 at the significant level of .05. (4) There a gender gap in students ability to proof in Abstract Algebra, but statisticcally not significant.


Impedance matching is a critical aspect of any RF or millimeter-wave (mm-wave) design. Although historically addressed with transmission lines or discrete elements, it can also be implemented with integrated transformers as their quality factors now reach decent values (approximately 10–20) at high frequencies (used at 77 GHz in this article) due to the thicker upper metal layers present in most integrated stacks.


This paper inquires on the inventors' productivity with regard to patents. The statistical methodology relies on the "Power Law" framework. We apply the Lotka's law and the usual instruments of "Pareto Law" on NBER Patent Citations Data File, finding that patents per inventor distribution is highly uneven. In depth, we can divide the whole inventors' population in subsets of "normal" and "important" inventors, in each period and country we considered. We also provide a theoretical interpretation of our outcomes. In particular, the results about different individual productivity in creating new ideas are shown to be tied both to updating with new ideas and to technological spillovers. Finally, both the theoretical interpretation and the empirical findings about a highly heterogeneous individual productivity could be a further candidate to explain a divergence in growth rate and income level between countries.


A programming language is a mathematical calculus, or formal language. Its goal is to express algorithms in a manner that is unambiguous to people and machines. Like any calculus, a language's notation contains both syntax and semantics. Since syntax can be easily translated, the semantics are more fundamental. Church and Turing showed that the minimal semantics of the Lambda Calculus and Universal Turing Machine are sufficient to emulate the semantics of any more complicated programming language or machine. Reducing a particular language to the Lambda Calculus may require holistic restructuring of programs in that language. We say that a particular language feature (e.g., continuations, macros, garbage collection) is expressive if it cannot be emulated without restructuring programs that use it.


Using visual and tactile senses to create emotions in brand image design can not only improve the quality of design works, but also provide psychological comfort to the audience and release the humanistic care of the brand. This article starts with the production of visual and tactile sensations and the elements that affect the visual and tactile experience to understand what brings us visual and tactile experience; and analyzes the relationship between the five senses and visual design; lists the visual and tactile creation methods that can be applied in the field of brand image design, and lists Classical cases are analyzed in detail; finally, starting from the development of network visual art, the visual and tactile experience and the constant changes in design are analyzed, and the application of visual and tactile sense in the field of brand image design is prospected.


The present meta‐analysis is aimed at assessing the effects of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors on all‐cause mortality and differences across different trials and molecules of the class. We included all randomized clinical trials with a duration of treatment longer than 52 weeks, enrolling at least 100 patients in each arm, and comparing an SGLT2 inhibitor with any comparator or placebo. Out of 139, 235 and 145 items identified, 21 trials were selected, enrolling 39 593 and 30 771 patients in SGLT2 inhibitor and comparator arms, respectively, with a median duration of 104 weeks, and reporting 2474 and 2298 deaths for SGLT2 inhibitors and comparators, respectively. No relevant heterogeneity was found (I2 = 17%). Treatment with SGLT2 inhibitors was associated with a significant reduction in all‐cause mortality (MH‐OR [95% CI] 0.86 [0.81, 0.91] P < .00001). Meta‐regression analyses found a significant direct association of treatment effect only with the proportion of Asian subjects enrolled, and an inverse correlation with the proportion of Caucasian patients. In conclusion, SGLT2 inhibitors reduce all‐cause mortality in randomized controlled trials.


Purpose: The basic idea of combination chemotherapy is to eradicate tumor cells through potent therapy before the appearance of resistant cells or an elevation in the number of the resistant cells. This article explores the use of combination chemotherapy in the treatment of solid tumors in head and neck.
Method: The efficacy of chemotherapy for head and neck tumors is specifically reviewed.
Results: Several hypotheses are generally well known and accepted as basic theories in cancer chemotherapy, and researchers have developed effective combination chemotherapy regimens based on these theories. Chemoradiotherapy was initially developed to regulate the local tumor through radiation and control distant metastases through chemotherapy. The purpose of adjuvant chemotherapy is to treat latent tumor cells that cannot be seen macroscopically after completion of first-line therapy. Continuous administration of a small dosage is a new concept that has recently been proposed to replace the conventional concept of total cell-killing.
Conclusion: This article examines the use of combination chemotherapy in the treatment of solid tumors and
reviews the efficacy of chemotherapy, which should be understood by head and neck surgeons.


AIM
To explore the possibility of cerebral hemodynamic reserve (CHR) normalization in patients with obstructive sleep apnea syndrome (OSAS), aged over fifty, who received continuous positive airway pressure (CPAP) therapy.

MATERIAL AND METHODS
The main group (20 patients, aged 50-65 years, with severe OSAS) and the control group (20 volunteers without snoring and OSAS matched for age and physical status) were studied. Diagnosis included cardio-respiratory monitoring of nocturnal sleep and ultrasound examination of cerebral blood flow with functional tests (breath holding and hyperventilation) and calculating the coefficient of vasomotor reactivity (CVMR) before the start of CPAP-therapy and after one month therapy.

RESULTS
The significant CVMR decrease in vertebral (VA) and basilar arteries (BA) in patients with OSAS compared to the control group was identified: 38.9±8.5 and 55.7±11.3 for VA, 36.8±15.7 and 54.0±5.4 for BA. After one month CPAP-therapy, no significant coefficient gains was observed: 38.9±8.5 and 42.3±9.1 for VA, 36.8±15.7 and 37.2±7.7 for BA.

CONCLUSION
The reduction of CVMR in patients older than 50 years with severe OSAS suggests the disturbance of CHR. The absence of its recovery within one month of CPAP-therapy may be indicative of the irreversible damage of the cerebral blood flow regulation mechanisms. Continued observations for a longer period are needed.


OBJECTIVE To determine the contents of berberine and phellodendrine in Phellodendron chinese from different collection periods and to discover the inherent rule about the content change owing to different collection periods. METHODS Luna C18 (2) (6.0mm×150.0mm, 5μm) clumn was used for the detection, with flow rate of 1ml•min^(-1) and column temperature of 30℃. The mobile phase berberine and phellodendrine were methanol-phosphate buffer-sodium dodecylphate (60:40:0.1) and acetonitrile ~0.4mol•L^(-1) ammonium chloride (12:88) with detection wavelength of 350nm and 286nm, respectively. RESULTS The contents of berberine and phellodendrine in female plants decreased in June, July, and Augest, but not in the male plants. CONCLUSION The contents of berberine and phellodendrine dramatically decreased in June, July and Augest, which was highly related to the time of blossom and early time of fructification.


A new conversion system for small size hybrid electric vehicles has been studied, aiming at the optimization of the energy flows among the generating and storage devices and the traction motor and looking for the maximization of the energetic efficiency of the whole conversion chain. A reduced scale prototype has been developed and the main results that have been obtained are shown.


Kalanamak cultivar of rice ( Oryza sativa L.), aromatic non-basmati rice cultivated in the northeastern part of the U.P, continuously received the researchers' attention because of its indigenous origin, nutritive values, and presence of a small genetic base. The long height of this cultivar causes crop lodging which results in a huge loss in its yield. The present work is focused to reduce the height of the cultivar and increase in yield. As the broad genetic base is a pre-requisite feature of any crop improvement program, hence, an attempt of induced mutagenesis was made using gamma radiation for genetic improvement of aforesaid indigenous rice. Seeds of Kalanamak rice were treated at different intensities of gamma radiation (100, 150, 200, 250, and 300) Gy, and the most effective dose was determined based on seed survival percentage and antioxidant enzyme activity. The dose of 150 Gy was identified as the most potent dose in the context of antioxidant enzyme activity, promotion of dwarfs, and increase in the number of tillers per plant, and grains per panicle.


Delayed cord clamping leads to the increased level of haematocrite and victocytes which is high risk of hyperbilirubinemia . This study is to determine if there is an effect of timing of cord clamping relating to the incidence of hyperbilirubinemia on newborn, and to create formulating the standard procedures in maternal interventions related to the timing of cord clamping, another objective is  preventing  interventions of its occurrence when the clamping is performed immediately after birth. Crossectional study was applied design of the research. Population and samples included infants spontaneus by healthy primigravidas.Two trials were included, 20 participants of each received interventions of cord clamping more than equalivalent 1 minute and less than 1 minute followed by bilirubin assessment 48 hours after birth, and analysed by using Linier Regression. There is no significant effect of timing of cord clamping on newborn with regard to hiperbilirubinemia, because the effect of the clamping on bilirubin level reaches up to 68.2%, while the other 31.8% of the varying levels are affected by other factors. There is a need to conduct other relevant studies aimed to prevent hyperbilirubinemia starting from antenatal to postnatal stage.
Key Words: Jaundice, Newborn, Hyperbilirubinemia, Time of Clamping, Primigravidas


Identifying early life stages of fishes to the species level is one of the challenging task for the taxonomist as the information on key morphological characters are overlapping between genetically closer individuals. Universal DNA barcode (cytochrome oxidase C subunit 1) gene sequence helped tremendously in species level identification of early life stages of fishes. This study was aimed to address the effect of recent monsoon on assemblage changes in Icthyoplankton and juvenile fishes of Kuantan river, Whereby, the samples were identified to the species level using COX1 gene sequencing. Samples were collected using modified bubu light trap net between April 2015 and December 2015 in Kuantan river and its all tributaries. Fish larvae/juvenile size ranged from 3mm to 100mm, with most abundant individual belong to size class <10mm. A total of 28 species belong to 15 families were successfully identified to the species level from the total of 58 barcodes generated from 372 larval/juvenile samples collected. Unlike the previous study, significant shift in species assemblage has been recorded in this study. Statistical analysis showed significant effect of salinity and suspended particulate on the species distribution and abundance. The dominant fishes belong to the cyprinidae family followed by toxotidae, ambasidae and eleotridae compared to the previous study (Ariidae, Lactaridae and Lutjanidae). It could be concluded that the recent flood (year 2015) in east peninsular Malaysia will have greater positive impact on Kuantan river fish diversity in near future.


A good health care system depends primarily on the quality of the professionals who built and manage it. Any attempt at bettering such a system must therefore start with improving medical training and the quality of the daily care provided by doctors, nurses, midwifes, orderlies, EMT's, paramedics and all the other professionals, who constitute the personnel in charge of the system. The present study focuses on the "Cote d'Ivoire" (Ivory Coast), and presents a plan for improving the training of health care professionals within in this West African country. Starting with an historical overview, we first look at the evolution of heath care training, from the beginnings of a formalized allopathic tradition all the way through to the present. Throughout, we highlight programs and initiatives that have worked as well as those that have proven less successful. Our goal was to understand and assess the challenges the country has faced over time in managing the health of citizens in order to identify appropriate solutions. We then present selected innovative, sustainable health care training models derived primarily from benchmarking "best practices" in other countries re notable results were proven. In doing so, we pay particular attention to contextualizing and adapting identified benchmarked models to the specific economic, social, cultural and political environment of the Cote d'Ivoire. One major conclusion of our analysis pertains to the pivotal role of medical law training. Our research stressed the importance of solidly training all health care professional in their understanding and mastery of medical law. This is key and a precondition to virtually any improvement of the system of health care in Cote d'Ivoire and beyond into the rest of Africa at large. A command of the legal parameters of their job not only empowers each heath care professional with a clear and conscious sense of his or her responsibilities towards patients, but it also guarantees the balance, fairness and the very quality of the overall health care system.


This paper investigates the existence and uniqueness of implicit solutions in a coupled symmetry system of hybrid fractional order differential equations, along with hybrid integral boundary conditions in Banach Algebras. The methodology centers on a hybrid fixed-point theorem that involves mixed Lipschitz and Carathéodory conditions, serving to establish the existence of solutions. Moreover, it derives sufficient conditions for solution uniqueness and establishes the Hyers–Ulam types of solution stability. This study contributes valuable insights into complex hybrid fractional order systems and their practical implications.


We extend Feynman's analysis of the infinite ladder AC circuit to fractal AC circuits. We show that the characteristic impedances can have positive real part even though all the individual impedances inside the circuit are purely imaginary. This provides a physical setting for analyzing wave propagation of signals on fractals, by analogy with the Telegrapher's Equation, and generalizes the real resistance metric on a fractal, which provides a measure of distance on a fractal, to complex impedances.


Keeping a player within the flow in a game is a central goal for game designers, making the game neither too easy nor too hard. Dynamic Difficulty adjustment seeks to fulfill this goal by dynamically tuning difficulty according to player actions in the game. In this paper we demonstrate that case-based reasoning with time series can serve to automatically identify the ability of a player in a game, and thus serve as the input for difficulty adjustment based on player ability. We try different configurations for the generation of the case base from game logs, and compare them in terms of how well they classify player ability.


In previous papers it was reported that uracil (10) and caffeine (14, 15) enhance the syntheses of both ribonucleic acid (RNA) and protein in various fruit tree species. Similar results were obtained with xanthine, while adenine and guanine, when applied at a rather early developmental stage of the plant, promoted the synthesis of deoxyribonucleic acid (DNA) (11). In addition it was later found by us that fruitful and non-fruitful trees differed in their relative levels of uracil (in some species fruitful species contained up to 80 to 170 % more uracil than their non-fruitful counterparts), and, in the case of olive trees, also in their xanthine levels. As a result of the above findings xanthine and uracil were applied to plants and were found, in some cases, to enhance flowering. These latter preliminary experiments were now extended to more species of deciduous and evergreen fruit trees as well as to a series of annual plants. In part of these experiments 2,3,5-triiodobenzoic acid (TIBA) which was found to promote flowering in grape vines (1) and several other plant species (4, 9) was also used for comparative purposes.


A comparative analysis of the prices of raw materials, fuel, electricity in Russia and Western countries, the dynamics of their growth and impact on the national economy. It is shown that in the interests of the country's economic development and improving the welfare of the population, it is necessary to use its natural resources more effectively, to pursue a more stringent and at the same time balanced policy to curb the growth of prices, taking into account the interests of the state and business.


Objective:To observe the prevention of glutathione(GSH)against chronic liver injury in rat.Methods:The chronic liver injury model was made by intracutaneous injection of carbon tetrachloride twice a week in rats for 24 times.From the 8th week after the carbon tetrachloride injection,GSH was given by oral or peritoneal administration once a day for 60 days.The animals were sacrificed at the end of the experiment.The serum level of ALT,AST were measured.The liver tissue was studied with histopathological or immunohistochemical assay.Results:GSH markly decreased the serum level of ALT,AST and improved liver tissue inflammation and lessend the liver fibrosis in histopathology compared with the model group.In the immunohistochemical stain,the deposition of type Ⅰ collagen of liver tissue significantly decreased in GSH treatment group compared with the model group.Conclusion:GSH can protect live from injury induced by toxic material.


In the modern market economy,salary management has a significant impact on the competitiveness of enterprises.This paper analyzes the problems of salary management of state-owned enterprises: lack of strategic orientation,lack of external competitiveness of the salary level,lack of perfect compensation assessment system,to explore the salary management of state-owned enterprises on the incentive theory and give the five main strategies to perfect the salary management of state-owned enterprises: design the salary strategy effectively,ensure the external competitive ability of the salary level,set up a scientific assessment system,improve the skills of salary management,make scientific use of the salary management art.


In this paper,we introduce the concept of maximal P-injective modules.Some basic properties of maximal P-injective modules and the special properties of maximal P-injective modules on domain rings were discussed.Then we introduce left maximal P hereditary ring and characterize it by maximal P-injective modules.


...................................................................................................iii ACKNOWLEDGEMENTS...................................................................................v CONTENTS....................................................................................................vi LIST OF TABLES............................................................................................viii LIST OF FIGURES.............................................................................................x INTRODUCTION.............................................................................................1 OBJECTIVES...................................................................................................6 LITERATURE REVIEW.....................................................................................7 SOIL PROPERTIES..........................................................................................7 Soil Compaction................................................................................................7 Soil Electrical Conductivity..................................................................................9 Near-Infrared Reflectance Spectroscopy (NIRS)........................................................14 SENSORS.....................................................................................................18 METHODS AND MATERIALS...........................................................................21 STUDY AREAS.............................................................................................21 METHODS...................................................................................................23 RESULTS AND DISCUSSION............................................................................31 CONCLUSIONS.............................................................................................39 vii LITERATURE CITED.......................................................................................40 APPENDIX...................................................................................................43 viii L IST O F T A B L ES


In order to study the measurement characteristic of flow for multi-jet wing water meter,a rotor driving torque and all resistance torques are deduced,and the flow measurement equation is given.Based on computational fluid dynamics(CFD) and turbulence model,a method of rotor-torque-balance is proposed,which can predict rotational speed of rotor precisely.Then flow field of multi-jet wing water meter is analyzed.Comparison between simulation results and the data of physical experiment shows the simulation methods of multi-jet wing water meter is acceptable for analyzing the measurement characteristic of flow.The maximum difference between simulation error and experiment error is 4.17 %.


Although the sequence-dependent setup times flowshop problem with the total weighted tardiness minimization objective exists widely in industry, work on the problem has been scant in the existing literature. To the authors' best knowledge, the NEHEWDD heuristic and the Iterated Greedy (IG) algorithm with descent local search have been regarded as the high performing heuristic and the state-of-the-art algorithm for the problem, which are both based on insertion search. In this article firstly, an efficient backtracking algorithm and a novel heuristic (HPIS) are presented for insertion search. Accordingly, two heuristics are introduced, one is NEHEWDD with HPIS for insertion search, and the other is the combination of NEHEWDD and both the two methods. Furthermore, the authors improve the IG algorithm with the proposed methods. Finally, experimental results show that both the proposed heuristics and the improved IG (IG*) significantly outperform the original ones.


Physical activity levels have been steadily decreasing over the last few decades. The role of physical activity in preventing non-communicable diseases, including obesity, heart disease and certain cancers, is increasingly recognised. International health bodies have called for urgent action to tackle the global pandemic of physical in activity. In addition to the traditional approaches of education and individual support to change activity, social and physical environments need to be addressed to create a context for behaviour change. The aim of this policy briefing is to describe recent advances in physical activity research that might help address the concerning levels of physical inactivity in Northern Ireland.


The experimantal results for H9+ ,H11+ and H13+ cluster ions are reported.The authors found that these cluster ions may be formed from the interaction of one H3+ ion and a few of H2 neutral moleculars. The dissociation ways of these cluster ions have been discussed.


In vocational college,there is quite a number of freshmen who are poor in English.This phenomena makes our teaching somewhat difficult.In order to solve this problem,we have to cultivate their learning autonomy.This will not only make up the knowledge they should have learnt before,fill in the broken layers,narrow the gap between their level and the level they have to get to,but also promote them to develop positive attitude and good strategy in learning,speed up their independent and continuable development.


The Abstrakte Oper Nr. 1 opposed operatic tradition through its use of a non-narrative text that represented archetypal emotions and states of being. The opera's main point of reference was Weimar Berlin: Blacher drew belatedly on Dada and cabaret and referenced New Objectivity and the German appropriation of jazz. Blacher also relied on many time-honored musical conventions from both opera and popular styles to convey the libretto's affects and situations, references that for many critics negated the piece's claims to "abstraction." The work created an uproar at its premiere as audiences and critics perceived politicized narratives in the work's purported nonsense. Detractors saw the piece as hastening the genre's demise, while its defenders affected a modernist rejection of audience complacency. Both sides saw the Abstrakte Oper as a political statement and seized the opportunity to accuse their opponents of having an unsavory relationship to the National Socialist past.


Contents: Introduction. Part 1 'Convential Views' and Perspectives on Neoliberal Globalization: The No Alternative Discourse: Understanding globalization The Third Way: globalization lite or real alternative?. Part 2 Contestation and Resistance to Neoliberal Globalization: Radical Alternative Visions: The deglobalization and anti-capitalism movement and alternative visions to neoliberal globalization The anti-capitalism movement and African resistance to neoliberal globalization. Part 3 Contemporary Applied Issues and the Reinvention of Democracy Through Mass Mobilization and Resistance: African social movements engagement with the New Partnership for Africa's Development (NEPAD) Articulating resistance to medical apartheid: the Campaign for HIV/AIDS drugs in Africa Against water privatization: the struggle continues Social movements and the campaign for debt cancellation: resisting debt domination Social movements and the new trade regime: an issue of fairness, not charity Index.


The global health crisis caused by COVID-19 led to the confinement of millions of people all over the world and generated an unprecedented global alarm. A consequence of the confinement was the suspension of face-to-face educational activity in all centres and levels of education, and the adoption of online modality. The aim of the chapter is to facilitate the understanding of the learning framework in online contexts and to explains some of the e-learning practices carried out by the University of Salamanca along the 2019-2020 academic year. It also offers a compilation of the strategies and lines of actions adopted by the university for the next academic year to guarantee the quality of the teaching learning process, to reinforce the technological equipment and telematic networks, to carry out a strong digital transformation of the institution, to bridge the digital divide, and to implement a training programme for teachers and students.


The article analyzes the research of scientists from different countries and strategies to combat the invasive species H.sosnowskyi Manden. Invasive species cause numerous damage to the economy, agriculture, some are a threat to human health. H.sosnowskyi is a strong competitor for nutrients, suppressing native species, and disrupts successional processes. The most common control methods are mowing, herbicides, grazing, cutting buds and digging. All these methods are expensive enough and not always effective, so scientists have begun to consider alternative methods of control. One of the promising areas under consideration is the extraction of biobutanol. Plant lignin can be used to make medicines; pectin can be used in the food industry. Control measures in Ukraine need to be implemented as soon as possible, as there is a risk of uncontrolled spread of this species, especially near housing estates and settlements. It is important to choose the right strategy of struggle, based on the experience of neighboring countries. To draw the attention of businessmen to the possible use of the plant in industry. Changes in legislation, implementation of monitoring programs will help stop the spread of invasive plant.


Each year, the U.S. National Institutes of Health (NIH) invests substantial resources in core facilities that provide access to advanced cutting-edge technologies, expert consultation, and other services to scientific investigators. The facilities offer a number of services, ranging from systematic analysis and data processing, using specialized instrumentation, to access and expert advice on experimental design and evaluation needs, such as biostatistics, patient outreach, and clinical regulatory issues. The largest fraction of support for cores comes from the institutes and centers of the NIH, for example, through the National Cancer Institute (NCI) and National Center for Advancing Translational Sciences (NCATS). Significant NIH investment is spent on Center Core grants, particularly the NCI Cancer Centers, and the Clinical Translational Sciences Award Program supported by NCATS. The Office of the NIH Director's Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) also has a substantial investment in animal and biologic resource centers that provide models of human biology and disease for basic to clinical studies to researchers around the world. Many of these centers function like cores, as they provide the following: 1) high-quality, disease-free animals; 2) access to sophisticated technologies and facilities, as well as specialized animals; and 3) expert training by professional staff and consultation services. As an example, the NIH-supported National Primate Research Centers provide facilities, animals, and expertise for investigators who use nonhuman primates for biomedical research, facilitating >1000 individual research projects annually. The DPCPSI investment in core facilities also includes support through its Shared Instrument Grant program to purchase or upgrade expensive, specialized, commercially available instruments or integrated systems. This program promotes cost effectiveness; encourages optimal sharing among investigators, research groups, and departments; and fosters a collaborative, multidisciplinary environment. In many settings, the instrument is integrated in a centralized core facility. Through these investments and many other programs not listed, NIH's annual support for research cores is estimated conservatively at $900 million. Given this large investment, it is critical that both NIH and the research institutions receiving support for these resources identify and implement approaches that enhance core resource efficiencies.


State Grid information construction has gained a great achievements in the wave of mobile Internet development and impact of the "Internet plus" action plan. At the same time, there are some problems in the informationizing of multi-dimensional marketing e-service channels, such as the overlapping of channels, the insufficient integration of channels and lack of data sharing in various channels. The complex business operation of the channels in the traditional single-architecture mode. After the development of the microservices architecture in the current industry research shows that microservices-based architecture model system can be very well to solve the problems encountered in the construction of information technology. The final multidimensional electronic channel system construction using Docker container technology as a microservices architecture technology solutions, which greatly improved the system capacity and operation and maintenance the efficiency of system, and also provided a strong technical support for the construction of national network information.


The paper investigates the performance of a typical anchored steel sheet-pile (SSP) quay-wall against sei mic motions of various intensities. The SSP wall has a "free" h ig t of 18 m and it supports medium-dense to dense , non-liquefiable sandy soils. The wall is subjected to two levels of eismic excitation with respect to the PGA at the rock-outcrop level, namely 0.15 g and 0.5 g. The investigation is perfo rmed: (i) according to long-established procedures that combine pseudo-static limit equilibrium method (pLEM) with e beam-on-Winkler-foundation (BWF), and (ii) by m eans of advanced finite element (FE) analysis with use of t wo commercially available codes (ABAQUS, PLAXIS). I t is shown that the simplified methodology, which works in con junction with the Mononobe-Okabe (MO) method, leads to results for the structural distress that can be significant ly larger than those computed by the FE analysis. T he advantage of performing detailed numerical analysis for such com plex soil-structure interaction problems is further mo e demonstrated by its ability to capture well the phy sical phenomena, leading to similar results despite the sensitivity to the soil constitutive model. Needless to say, the m ere possibility of liquefaction must be excluded or mitigated by suitable soil improvement.


In case of Quadrature amplitude modulated (QAM) transmission, the residual carrier affects the quality of the received signal. We show that the carrier tracking problem is equivalent to a time-varying Blind source separation (BSS) problem if there exists a residual carrier. This motivates us to propose a new receiver architecture, that is tolerant to residual carrier, based on a Recursive least squares (RLS) BSS algorithm. Simulations are provided to show the promising performance of the proposed algorithm for tracking the residual carrier and for improving the quality of the received signal.


A promising three-level (3L) topology for ultrahigh-speed (UHS) motor applications is a sparse neural point clamped (SNPC) inverter that can generate 3L voltage output and is the cheapest among other 3L counterparts. Using all SIC switches can increase the switching frequency and considerably improve the performance of the UHS drive system. However, increasing the switching frequency results in a significant dead-time effect. Therefore, the quality of the output phase current reduces considerably. Compared with other conventional 3L and two-level (2L) topologies, the SNPC topology has a distinct dead-time voltage error generation principle. Therefore, dead-time compensation methods cannot be directly applied. In this study, first, the dead-time voltage error generation principle for SNPC topology was analyzed. Next, the obtained voltage error expressions were used to perform the Fourier analysis. The derived dead-time voltage error equations in the frequency domain are compared with other conventional 2L and 3L topologies. Finally, a novel adaptive dead-time compensation method was proposed based on the results obtained from the Fourier analysis. An experimental setup based on the high-frequency SIC-SNPC inverter and UHS motor was developed to verify the feasibility of the proposed compensation method.