Abstract The paper is focused on the studies of the microstructure development and physical and mechanical properties of metal-matrix composite coatings based on steel 11Cr18MoWCu deposited using plasma and galvanoplasma methods. The expediency of combining gas-thermal spraying processes of plasma coatings with open porosity up to 16%–18%, with their subsequent thermodiffusion saturation (chromium plating) or liquid-phase impregnation with eutectic alloys of previously applied Ni–B galvanic layer, is shown. The study of the tribotechnical properties of the proposed coatings showed a significant improvement in their performance under conditions of various types of intensive wear, as well as in corrosive environments.


ABSTRACT The current study examined the independent and combined effects of HIV and marijuana (MJ) use (no use, light use, and moderate-to-heavy use) on neurocognitive functioning among a convenience sample of HIV-positive (HIV+) and HIV-negative (HIV–) individuals recruited from HIV community care clinics and advertisements in the Greater Los Angeles area. MJ users consisted of individuals who reported regular use of MJ for at least 12 months, with last reported use within the past month. Participants included 89 HIV+ (n = 55) and HIV– (n = 34) individuals who were grouped into non-users, light users, and moderate-to-heavy users based on self-reported MJ use. Participants were administered a brief cognitive test battery and underwent laboratory testing for CD4 count and viral load. HIV+ individuals demonstrated lower performance on neurocognitive testing than controls, and moderate-to-heavy MJ users performed more poorly on neurocognitive testing than light users or non-users. Moderate-to-heavy HIV+ users performed significantly lower on learning/memory than HIV– moderate-to-heavy users (MD = −8.34; 95% CI: −16.11 to −0.56) as well as all other comparison groups. In the domain of verbal fluency, HIV+ light users outperformed HIV– light users (MD = 7.28; 95% CI: 1.62–12.39), but no HIV group differences were observed at other MJ use levels. HIV+ MJ users demonstrated lower viral load (MD = −0.58; 95% CI: −1.30 to 0.14) and higher CD4 count than non-users (MD = 137.67; 95% CI: 9.48–265.85). The current study findings extend the literature by demonstrating the complex relationship between HIV status and MJ use on neurocognitive and clinical outcomes.


The global financial crisis in an early autumn of 2008 has come and to the post-Soviet territory enterprises. Money supply compression, sharp falling demand on an industrial output, the chains of defaults of payment threatening by rupture of economic relations caused by it, mass reductions and production stops became its basic symptoms.


Abstract Although experimentation is a crucial stage in the process of research and development of industrial products, no satisfactory procedure is available to deal with the common but rather important industrial problem of defining a preference ranking among all the studied product prototypes on the basis of performances. In this paper we propose a two-stage non-parametric procedure in which we firstly perform a set of C-sample testing procedures, followed by multiple comparisons, in this way evaluating a set of partial preference rankings, and secondly synthesise the partial rankings by combining them into a global ranking that provides a general product preference rule. The proposed method is particularly useful in the context of industrial experimentation and offers several advantages such as effectiveness, high flexibility and practical adherence to real problems where preference ranking is a natural goal.


To investigate detailed combustion process in scramjet,flamelet sub-grid model is presented for supersonic turbulent combustion,and hybrid LES/RANS method is used to simulate supersonic flow and combustion in the hydrogen fueled scramjet.Governing equations of large scale eddies were solved with fifth-order WENO scheme,and Runge-Kutta scheme was adopted for time iteration.The results show:(1) the distribution of fuel in non-reacting flow is similar to vortex,which reveals that mixing is controlled by large eddy scales;(2)vortex becomes larger and lies on the flame surface in reacting flow,also the distribution of temperature and water are similar to vortex,which reveal that combustion is controlled by large eddy scales;(3)numerical results obtained good agreement with shadow pictures,velocity measurements,and temperature measurements qualitatively and quantitatively,which reveal that the method and combustion model in this paper can predict both the non-reacting and reacting flow-fields reasonably well.


Having negotiated challenges that contributed to the deterioration of most other unions, the United Packinghouse Workers of America entered the second half of the century with widespread support among packinghouse workers and a strong sense of purpose. In the late 1950s, however, meatpacking companies began a radical reorganization of the industry's system of production. Within the next decade, significant deskilling, the collapse of wage standards, and numerous plant closings facilitated the political emaciation of organized labor in meatpacking. Using event-structure analysis to systematically examine and compare labor struggles in the postwar years (1946-1948) and during the Reagan era (1986-1987), the authors find that the development of new corporate strategies fundamentally transformed the capital-labor relationship and led to the collapse of industrial unionism in meatpacking. Most important were the industry's development of new technologies, its geographical reorganization of production, and its ability to locate new sources of cheap, nonunion labor.


Following previous long term pitting and cracking tests of a 3 NiCrMoV steam turbine disc steel, supplementary short term exposure tests have been carried out in an out-ofspecification water chemistry, viz. aerated water containing 1.5 ppm Cl. The disc steel was in the form of cylindrical tensile test specimens self-loaded to 50%, 70% and 90% of σ0.2. The pit growth law was evaluated to be . Threshold pit depths for initiation of stress corrosion cracks were determined. 49 . 0 7 10 9 . 1 t a pit − × = NPL Report DEPC MPE 014 © Crown copyright 2005 Reproduced with the permission of the Controller of HMSO and Queen's Printer for Scotland


ABSTRACT The last 10 years has seen a dramatic increase in the number of parents in the United States choosing to homeschool their children instead of sending them to public school. One report had the number increasing by 61.8% from 2003 to 2012, with the total number of homeschooled children reaching nearly 2 million (Snyder, T. D., and S. A. Dillow. 2015. Digest of Education Statistics 2013 (NCES 2015-011). Washington, DC: National Center for Education Statistics, Institute of Education Sciences, U.S. Department of Education). With more students withdrawing from public education to a more insulated environment (often due to religious reasons), there are concerns about the long-term ramifications this trend may cause. This paper addresses the degree to which a religious homeschooled education might be problematic within John Dewey's conception of education as laid out in Democracy and Education. For Dewey 'Common subject matter accustoms all to a unity of outlook upon a broader horizon' (Dewey, John. 1985. Democracy and Education, Collected Works. Middle Works Vol 9, 26. Carbondale: Southern Illinois University Press). I argue that persons raised in a virtual vacuum in which education is rooted within a particular faith may be less capable of serving as vibrant members of a democratic-based society.


The present investigation was conducted during the Rabi seasons of 2017–18 and 2018–19 at the Horticultural Research-cum-Instructional Farm, Department of Vegetable Science, Indira Gandhi Krishi Vishwavidyalaya, Raipur (C.G.). The field experiments used a Randomized Block Design (RBD) with three replications and treatments that included RDF (100%), RDF (75%), Borax (20 kg ha-1), Ammonium Molybdate (2 kg ha-1), and ZnSO4 (25 kg ha-1). During the study, various yield parameters, gross curd weight (g), net curd weight (g), curd diameter (cm) the final yield, and quality parameters, total soluble solids (oBrix), protein content in curd (%)  and ascorbic acid content in curd (mg/100g) were recorded. The experimental findings revealed that almost all the treatments showed a positive effect on yield and quality; however, a combined application of 100% RDF with Borax at 20 kg ha-1, ammonium molybdate at 2 kg ha-1, and ZnSO4 at 25 kg ha-1 was found most promising compared to the control (100% RDF). Therefore, based on the findings, it can be concluded that the application of micronutrients along with the recommended fertilizer dosage is an effective approach for enhancing the performance of cauliflower in terms of both quality and quantity.


For the avoidance of doubt, by applying this licence the Commonwealth of Learning does not waive any privileges or immunities from claims that it may be entitled to assert, nor do the Commonwealth of Learning submit to the jurisdiction, courts, legal processes or laws of any jurisdiction. Prefatory note: At a time when the global community of OER stakeholders and enthusiasts are celebrating a decade of growth in OER, we at COL would like to highlight the importance of overcoming the producer-consumer divide in the OER paradigm. We have argued that a user should be enabled to be a producer of OER as well. With this purpose in view, COL has encouraged thought and efforts to advance the tools and opportunities for re-use and adaptation of OER in various contexts. This report, authored by Mr. Ishan Sudeera Abeyawardena of Wawasan Open University (WOU), Malaysia, is a significant contribution in that direction. A sizeable part of OER use and re-use occurs, and will continue to occur using personal computers (PCs). There are clear indications that use of OER is becoming limited by the lack of PC-based tools that could enable easy and credible re-use and adaptation. Informal analysis of results from multi-country surveys in Asia organised by OER-Asia in 2011-2012 reveals that this is indeed the case, even with users in better-endowed institutions. In this report, Mr. Abeyawardena has provided concise overviews on a host of different tools that can enable re-use and adaptation of re-use on a PC. It is most of the tools he has described are Open Source tools, thus eliminating one layer of costs in the re-use process. He has also provided case studies on how re-use can lead to credible new material. This report was developed by Mr. Abeyawardena over a period of time he spent at COL's headquarters in Vancouver on an Executive Secondment. We thank him for his contribution and thank the Vice Chancellor of the WOU for the support extended to Mr. Abeyawardena. A number of colleagues in COL gave advice and support towards development of this report with Dr. V Balaji serving as the principal advisor. We hope the global OER Community will find this report a useful resource in the effort to advance the OER paradigm.


The Argument In most historical accounts, eugenic doctrines and Christian beliefs are assumed to be adversaries. Such a perspective is too narrow, however, for while many prominent eugenicists were indeed religious skeptics, others sought to reconcile eugenics with Christianity. Various American Protestant social reformers tried to synthesize new biological theories with older biblical ideas about the meaning of a good inheritance. Such syntheses played an important role in disseminating eugenic doctrines into America's deeply Protestant heartland.


Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.


We used the method of numerical calculation,computed four schemes of the structure of semi-ellipse rotation type shaft bottom and twelve schemes of snick shaft bottom,and attained the stress distribution of snick superior to semiellipse shaft bottom.We further analyzed about snick shaft bottom,attained optimal structure style of snick shaft bottom and distribution rule of stress.These put forward to theory for diggings of LiangHuai and Shandong in special thick alluvium about drilling shaft bottom.


We investigate a high-order homogenization (HOH) algorithm for periodic multilayered stacks. The mathematical tool of choice is a transfer matrix method. Expressions for effective permeability, permittivity and magnetoelectric coupling are explored by frequency power expansions. On the physical side, this high-order homogenization uncovers a magnetoelectric coupling effect (odd order approximation) and artificial magnetism (even order approximation) in moderate contrast photonic crystals. Comparing the effective parameters' expressions of a stack with three layers against that of a stack with two layers, we note that the magnetoelectric coupling effect vanishes while the artificial magnetism can still be achieved in a center symmetric periodic structure. Furthermore, we numerically check the effective parameters through the dispersion law and transmission curves of a stack with two dielectric layers against that of an effective bianisotropic medium: they present a good agreement in the low frequency (acoustic) band until the first stop band, where the analyticity of the logarithm function of transfer matrix ($\log\{T\}$) breaks down.


The term 'differences of sex development' (DSD) defines a wide spectrum of conditions in which the development of chromosomal, gonadal or anatomical sex is atypical. Presenting at birth or puberty, or as primary subfertility, the precise diagnosis is difficult, the clinical management is controversial and multidisciplinary team care is imperative. Following reclassification of the nomenclature and numerous advances in the field of molecular genetics, our understanding of the aetiologies underpinning these conditions has expanded. While optimal management of DSD remains controversial, it is clear that individualised, patient‐centred and multidisciplinary care is paramount.


A substantial series of pottery was submitted to me from both the Plumpton Plain sites. Its examination has emphasized the distinction of date between them. It will appear that Site A belongs to the earlier part of the Late Bronze Age, from perhaps about 1000 B.C., whereas Site B cannot be dated before about 750 B.C., and covers the transition to the Early Iron Age in the period approximately centred on 500 B.C.


The disc brake device 10 comprises a hub 12 and disk 14. The hub is provided to rotate about a center axis of rotation 22. Disc 14 is slidable on the hub 12 in a direction parallel to the center axis of rotation (22). In addition, having a number of elastic presser provided between the sheet hitting the hub 12 and the disk 14, the press machine 34 applies a force in the radial direction on the disk 14. Pressurizer 34 is circumferentially arranged around the hub 12.


According to various embodiments of the present invention, disclosed are a method and a device for a flight of an unmanned electronic device capable of flying such as an unmanned aerial vehicle (UAV), a drone, etc. The electronic device comprises: a gimbal; a first camera for capturing an image; a second camera for detecting a feature point of the ground as an input image; at least one sensor set to detect the movement of the electronic device; a first motor for boosting associated with the flight of the electronic device; a second motor for driving to enable the first and second cameras to level off; and at least one processor electrically connected to the first camera, the second camera, the at least one sensor, the first motor, and the second motor.


Objective To determine the active constituents from Gardenia jasminoides against acute lymphoblastic leukemia.Methods Compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis(IR,ESI-MS,1H-NMR,13C-NMR).The inhibitory activity against the proliferation of HL-60,REH and Raji cell lines was determined by using MTT assay.Results Eight compounds were isolated and identified as β-sitosterol(1),5-hydroxy-7,3′,4′,5′-tetramethoxyflavone(2),Ursolic acid(3),D-mannitol(4),geniposide(5),deacetylasperulosidic acid methyl ester(6),genipin-1-β-gentiobioside(7) and scandoside methyl ester(8).Compound 3 exhibited inhibitory effects on leukemic cell proliferation in vitro with IC50 of 12.2,7.5 and 15.4 μg/mL aginst HL-60,REH and Raji cell lines,respectively.Conclusion Ursolic acid might be one of the active ingredients against anti-acute lymphoblastic leukemia conferred by Gardenia jasminoides Ellis.


This article mainly uses the research data as the basement.The paper tries to analysis the use of media of minority in Aletai region,and depicts the spread effect of broadcast and television status in quo in minority region.So as to find the spread existent problem in different media on that area,and it may play a reference role to solve these problems.


Energy recovery from solid waste has been common in Europe for many years. In the last 10 years the number of these facilities built in the United States has been increasing. However most of the solid waste energy recovery facilities have been built in large cities such as Nashville, Tennessee, Saugus, Massachusetts, Akron, Ohio, and Chicago, Illinois, using the well-developed water-wall furnaces similar to those found in large utility plants. The technologies available in sizes applicable to smaller communities have been found wanting in reliability and in the capability for producing high pressure steam to drive turbines. The water-wall rotary combustors being installed in a facility in Sumner County, Tennessee, offer the promise of reliability and capability heretofore not available to smaller communities.


Most victims of sex offenses are not seen by psychiatrists, and the only medical treatment they receive is administered by the family physician. Victims of sex offenders may be adult women or male or female children. Sexual molestation invariably produces disruptions in psychological equilibrium. While many victims are able to resume normal patterns of life without difficulty, others develop symptoms which may be extremely distressing and tenacious. The alert physician through careful history-taking and examination can identify those people who are likely to require additional care. He then has the opportunity to treat these people himself or to make appropriate referrals to psychiatrists or community agencies. The willingness of the physician to deal directly with these problems can lead to significant benefits to the patient.


E-learning is an essential part of today's education. This article reports a design research conducted to develop an e-learning web-based module at the Primary Education Department of Syiah Kuala University in Indonesia. The study employed the Four-D Model of instructional development which consisted of Define, Design, Develop, and Disseminate. This article focuses on the Develop stage where the users' perception was assessed regarding the implementation of the module. A number of 19 third semester students participated in the study. The data was collected using a questionnaire and interview. The questionnaire was constructed based on the Technology Acceptance Model (TAM) which suggested that two factors influencing someone's acceptance of technology were perceived usefulness and perceived ease of use. The result showed that the students perceived the e-learning web-based module to be useful in improving their understanding, independence, self-discipline, motivation to learn, and interactions with each other and with the teacher. The students also agreed that the e-learning web-based module was easy to use. This study implies that the inclusion of technology in education at the university is beneficial.


1. The response of tomato, radish, sunflower, soybean, and marigold to a-cyano-β (2,4-dichlorophenyl) acrylic acid is described. The chemical inhibited growth of the first four species; and it delayed flowering in the latter, but no deleterious effects on the flowers were noted. 2. A study of several related compounds suggests that the diethanolamine salt is the most effective in retarding the growth of tomato plants. It is believed that additional experiments are warranted.


Field-ion microscopy of semiconductores is now becoming a popular research project in many laboratories. However, it is still not easy to get good field-ion images (FI images) of semiconductores and to interprete the obserbed images. We present here some computer simulations of the field-ion images of Si obtained by using a low-cost microcomputer. Using the conventional thin shell method for image formation, FI images of Si tips oriented along [111], [110] and [100] directions were simulated and compared with the experimental FI images. A good agreement was obtained in the case of the [111] oriented tip surface, while in other cases a detailed comparison was found to be difficult because of the lack of sufficient resolution in the observed FI images. This work can be extended and applied to the study of metal-semiconductor interfaces.


The Internet of Things (IoT) boom has revolutionized almost every corner of people's daily lives: healthcare, environment, transportation, manufacturing, supply chain, and so on. With the recent development of sensor and communication technology, IoT artifacts, including smart wearables, cameras, smartwatches, and autonomous systems can accurately measure and perceive their surrounding environment. Continuous sensing generates massive amounts of data and presents challenges for machine learning. Deep learning models (e.g., convolution neural networks and recurrent neural networks) have been extensively employed in solving IoT tasks by learning patterns from multi-modal sensory data. Graph neural networks (GNNs), an emerging and fast-growing family of neural network models, can capture complex interactions within sensor topology and have been demonstrated to achieve state-of-the-art results in numerous IoT learning tasks. In this survey, we present a comprehensive review of recent advances in the application of GNNs to the IoT field, including a deep dive analysis of GNN design in various IoT sensing environments, an overarching list of public data and source codes from the collected publications, and future research directions. To keep track of newly published works, we collect representative papers and their open-source implementations and create a Github repository at GNN4IoT.


The advantages and disadvantages of the previous predistortion methods for high power amplifiers (HPA) in orthogonal frequency division multiplexing (OFDM) transmitter were compared and summarized systematically.Block-oriented model-based adaptive digital predistortion technique was presented to compensate for the distortions in HPA with memory.The proposed predistortion schemes were explained,where the adaptive predistorters of HPA with memory were constructed based on Wiener model,Hammerstein model and Wiener-Hammerstein model,respectively.Thus,the complexity of the model parameters of all aspects of Wiener-Hammerstein estimated is avoided,separately.This makes the predistortion design of a high power amplifier with memory became simple.


Adequate capacity planning requires accurate forecasts of the future magnitude and timing of peak electricity demand. Electricity demand is affected by the day of the week, seasonal variations, holiday periods, feast days, and the weather. A model that provides probabilistic forecasts of both magnitude and timing for lead times of one year is presented. This model is capable of capturing the main sources of variation in demand and uses simulated weather time series, including temperature, wind speed, and luminosity, for producing probabilistic forecasts of future peak demand. Having access to such probabilistic forecasts provides a means of assessing the uncertainty in the forecasts and can lead to improved decision making and better risk management.


Mobile commerce, a subset of e-commerce, conducted through mobile devices using wireless telecommunications network is poised to change the market place globally. According to Jupiter Research, Mobile commerce (m-commerce) industry is expected to be 22 billion USD globally. In Thailand, users seem to believe that general content such as news, weather and sports should be low-cost or free. However, innovative pricing schemes and services are expected to attract more users. Thus, the understanding of the value space between e-commerce and m-commerce is becoming important, so innovative services can be targeted to attract more users towards m-commerce. In this paper, the authors have attempted to identify and understand the adoption issues and value space between e-commerce and m-commerce in Thailand, by primarily surveying students from a private university in Bangkok. In this study, we have been able to identify that "ubiquity" or "everywhere available" value drives the adoption and usage of mobile device as theorised in earlier research.


The Sentence analyzed a turning point through which the Supreme Court changed years of jurisprudence. The figure par excellence was the Regulation on Workplace Relations. Through this analysis we can see, the criteria have changed, and is no longer the regulatory regime to follow according to the Supreme Court. Finally make an analysis by way of conclusions drawn following its comparative legal regime with the previous figure.


This paper introduces the phase error caused by the phase shift method in initial stages using integral for reactive power measurement and puts forward a solution.The characteristic of a practically available model are discussed such as the effect of sample frequency frequency response and etc.


The Singular Value Decomposition(SVD) is a special matrix transform with very good properties.This paper makes full use of the properties of SVD,and proposes a new quantization watermarking algorithm based on block SVD and a new spread spectrum watermarking algorithm based on block SVD.Both of the two algorithms embed watermark by altering the largest singular value of each data block,thus they can adjust the block size according to the amount of the watermark to be embedded,and their complexities are very low.The quantization watermarking algorithm is a method that makes use of the side information,and it's a blind algorithm.The experiment results show that watermarking algorithms based on block SVD are very robust to usual image manipulation attacks,especially the quantization watermarking algorithm.


The Georgi-Machacek (GM) model is a distinctive TeV-scale extension of the Standard Model (SM) due to the introduction of two (one real and one complex) scalar triplets to the Higgs sector. It predicts the existence of doubly charged Higgs bosons $H_5^{\pm\pm}$ and the vacuum expectation value of Higgs triplets $v_\Delta$ can reach a few tens of GeV. In this paper, we perform a parameter scan of the GM model within the H5plane benchmark scenario and investigate in detail the single production of a doubly charged Higgs boson in association with a SM-like Higgs boson via vector-boson fusion at the $14~ {\rm TeV}$ LHC and $70~ {\rm TeV}$ Super Proton-Proton Collider. Both integrated cross section and differential distributions with respect to some kinematic variables for $pp \rightarrow W^{\pm}W^{\pm} \rightarrow H_5^{\pm\pm} h^0 + 2\, {\rm jets}$ are provided up to the QCD next-to-leading order. In the signal-background analysis we employ the {\sc madspin} method to take into account the spin correlation and finite width effects of the intermediate Higgs and $W$ bosons and present some kinematic distributions of final leptons. The numerical results show that the SM background can be suppressed remarkably and the $H_5^{\pm\pm} h^0$ vector-boson fusion signal can be directly detected at future high-luminosity, high-energy hadron colliders by imposing a proper cut on the transverse mass $M_{T, \ell_1 \ell_2}$.


Pinyon-juniper woodlands are a dominant vegetation type across the Intermountain West, covering an estimated 30 million ha. Increases in density, cover, and aerial extent over recent decades have been associated with altered fire regimes, tree mortality, and reduced understory productivity. In our study we sought to determine how environmental factors influence woodland structure and to exploit such abiotic influences to improve our ability to model woodland structure from digital aerial photography. We developed and applied a methodology for automated tree canopy cover mapping using an object-oriented classifier. The resulting classification was used to scale up stand inventory measurements (0.1 ha) across 11 mountain ranges to a 3,250 km 2 area. Predictive models were compared with field-measured values from a validation sample for tree canopy cover, basal area, height, and stand density index. Linear mixed-effects regression models demonstrated consistent relationships between woodland structure attributes and environmental variables. More productive sites supported greater tree densities, whereas less productive sites supported fewer, larger trees. Relatively weak relationships for certain variables (e.g., tree height) suggest that woodland structure-environment relationships are partially obscured by natural disturbances and land use history. FOR .S CI. 55(1):1-12.


General Mathematics Self Assessment 1. General Mathematics 2. Ratio & Proportion 3. Safe Medication Administration 4. Drug Measurements and Oral Dose Calculations 5. Injectable Medication Calculations 6. Medication from Powders and Crystals: Oral and Intramuscular 7. Basic Intravenous Calculations 8. Advanced Intravenous Calculations 9. Parenteral Nutrition 10. Insulin 11. Anticoagulants 12. Children's Dosages Multiple Choice Final Comprehensive Final Answer Key Index


Purpose – This article seeks to summarise the recent publication, Turning the Tide: A Vision Paper for multiple needs and exclusions by Revolving Doors and Making Every Adult Matter. It addresses the significant financial and social costs of society's failure to support the 60,000 adults facing multiple needs and exclusions in England today and how this damage can be prevented.Design/methodology/approach – In total, six qualitative evidence seminars and a series of individual meetings were held, with 60 stakeholders consulted. The paper draws on the expertise of member agencies, partners, and the members of Revolving Doors' service user forum who have direct experience of multiple needs and exclusions.Findings – People facing multiple needs and exclusions experience several problems simultaneusly, have ineffective contact with services and, as a result, live chaotic lives. They are a small group but impose disproportionate costs on themselves, families, communities and the public purse. The paper sets out...


There are seven Uses of "zheyang" in SanYan.They are "zheyang+noun","zheyang+quantitative phrase","zheyang+attribute-head phrase","zheyang+adjective","zheyang+verb","noun+zheyang","verb+zheyang".In these uses,"zheyang" is used as attribute-head phrase,demonstrative-classifier phrase,demonstrative pronoun and adverb.From the four uses we can find the grammaIticalization of "zheyang".


According to the industries relationships of both sides, we can divide the merger into three types, such as the horizontal, vertical and conglomerate. When the enterprises in the different stages of the industry life cycle taking the different types of the merger, their performances are different too. Through this relation, we can examine the efficiency of the Market for Corporate Control of the listed companies in China. Through analysing the empirical examples of 298 samples in 1999~2002 years that showed, we make the conclusion that the efficiency of the Market for Corporate Control of listed companies in China is still not high.. At last, this text tries hard to give an explanation to this phenomenon and puts forward several possible reasons.


Most studies on osmium-containing redox polymers have been carried out in aqueous media. The rate of charge transport through the osmium-containing redox polymer as a function of solvent properties has not been investigated. This paper reports studies of osmium-containing redox polymers in five nitrophenyl-based solvents:  nitrobenzene, 2-nitrotoluene, 3-nitro-o-xylene, 2-nitrophenyl pentyl ether, and 2-nitrophenyl octyl ether. These solvents differ from solvents conventionally used for studying osmium-containing redox polymers, such as water and methanol, in that they have both high dipolarities and larger molecular sizes. Both chronoamperometry and cyclic voltammetry studies on those solvents indicate that it is the solvent size rather than the solvent polarity that determines the rate of charge transport through the osmium-containing redox polymer. The larger the solvent size, the slower the charge transport. We also found that the type of counterion has a strong effect on the cyclic voltammetry of the...


Article is devoted to consideration of antonymic opposition's functions in K. Balmont's texts. The antonymic opposition is considered to be the significant unit promoting reflection of author's outlook. The author comes to a conclusion that there is a multifunctionality of antonymic oppositions in a K. Balmont's linguistic world view.


The periodicity of a voiced-sound signal can reflect physiological conditions such as identity, age, and voice disorder. One way to look into this periodicity is to measure the temporal variability of vocal fundamental frequency (F0). This paper proposes 2 measures of F0 variability based on glottal closure instant (GCI). GCI is essential to the detection of F0 when the signal waveform varies substantially between adjacent cycles, e.g., in breathy voice. Frequency-selective variability measurements are taken from an interpolated sequence of fundamental-period values based on GCIs, including certain spectral-shape parameters which constitute a multi-variate measure. The utility of these measures was demonstrated in two experiments designed for interand intra-speaker comparisons, respectively.


In this paper we discuss why and how we combined the advantages of digital technology with physical manipulatives to scaffold children's learning of letter shapes, names, and sounds. Tangible interactions have been shown to lead to greater learning gains than traditional instruction in several contexts and subject matter. Yet most children are learning their ABCs the same way as they were taught more than a hundred years ago. If there was an engaging, interactive, hands-on alternative to learn the ABCs, what would it look like? To answer that question, we embarked on a design-based research journey based on continued user evaluations and redesign cycles informed by quantitative and qualitative assessments. Inspired by Fröbel and Montessori manipulatives, we discuss the design tradeoffs faced as playful learning goals balanced against constraints including healthy screen time limitations, fine motor control, competing attention targets, and choking hazards.


Health in focus Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity1. The highest possible level of physical and mental health is one of the fundamental human rights. It determines so the life and life quality of people as the income production capacity of a society. Thus, the existence and availability of information necessary to increase the efficiency of health preservation and improvement becomes more and more important. Some pieces of information concerning health can be obtained solely with the help of health survey questionnaires, as data received from health care institutions do not inform among others about lifestyle and social factors influencing health, about the expenditure of the population spent on health and about the satisfaction with the health care system. Over the course of data collection, it also becomes clear how often the respondents visit their general practitioners, dentists, whether they take part in screenings, what they do in the interest of their health (physical exercise, conscious nutrition), as well as it reports about health-damaging habits (smoking, alcohol consumption). In the last two decades, three representative, national interview surveys were conducted in the field of health; in 1994 under the guidance of the Hungarian Central Statistical Office and in 2000 and 2003 under the professional supervision of the National Centre for Epidemiology. However, the comparison of results is limited as the sample from the observed population and some of the questions and possible answers were different. Due to the subjectivity of self-assessment of health, this method is neither sufficient itself for establishing the actual health conditions of the population. It is necessary to know and take into account the statistics of general practitioners and other health institutions and to analyze the data from the two mentioned sources together as well. One of the most important objectives of the health programme of the EU for 2008–2013 is to provide comparable data about the health conditions of the European citizens. In the interest of this objective, EU lays great emphasis on elaborating health indicators and on activities connected to data collection. The European Parliament and Council Regulation put into force in December 20082 ordered the execution of health interview surveys in the member states. According to the plans, surveys conducted on the basis of a uniform methodology will be repeated every five years, thus, we can obtain information on the health conditions and changes in lifestyle of the population which are comparable on EU level as well. In Hungary, the first internationally standardized European Health Interview Survey (EHIS) was conducted in the autumn of 2009 under the guidance of the Hungarian Central Statistical Office3, and, in parallel, the National Institute for Food and Nutrition Science carried out a survey on a subgroup of respondents about nutrition and feeding conditions. In the framework of EHIS, we observed in 2009 the population aged 15 years and older. The results reflect so the health conditions and lifestyle of the population over 14 years of age living in private households, as children under 15 years of age and people living in institutions were not surveyed.


International peace missions face a fundamental dilemma between their aims of ending conflict and also fostering good governance. This study presents empirical evidence that more is not better in international peacekeeping: more authority vested in a peace mission yields less effectiveness in curbing corruption.
Its author applies a framework that uses the intrusiveness of international peace missions to study their effects on corruption. Bridging the gap between large-N quantitative studies and single case studies, the study pursues a mixed methods design, employing statistical analyses as well as qualitative case studies of Sierra Leone, Côte D'Ivoire, Kosovo and Croatia. The analysis shows that highly intrusive peace missions are more likely to enable corruption than to constrain it. By contrast, missions with medium levels of intrusiveness are more likely to contribute to better control of corruption by acting as impartial arbitrators and by conditioning external assistance.


Vikram Sarabhai (1919-71), the renaissance man of Indian science, visualized the impossible and often made it happen. Amrita Shah's "Vikram Sarabhai: A Life" is the story of this dynamic visionary. Born into an immensely wealthy and politically conscious business family, Vikram had an early understanding of the power of money and the problems of a newly independent nation, to which he married a deep love for physics. Between 1947 and 1971, he built a thriving pharmaceutical business, conducted research into cosmic rays, set up India's first textile research cooperative, ATIRA, the first market research organization, ORG, the Indian Institute of Management in Ahmedabad and the dance academy Darpana. He also headed the Atomic Energy Commission and laid the foundations for the world's first entirely peaceful space programme. Good-looking, charismatic, married to the glamorous classical dancer Mrinalini and closely associated with the most influential figures of his time - C.V. Raman, Jawaharlal Nehru, Indira Gandhi, Homi Bhabha, Bruno Rossi, Louis Kahn and John Rockefeller III - Vikram seemed to have led a charmed existence. Yet, his personal life was troubled and his strong resistance to India's move towards a nuclear explosion in the late 1960s put him at odds with powerful lobbies and fellow technologists. Amrita Shah delves into the life and mind of this fascinating, complex individual.


Quality control before analysis is the prerequisite to assure accuracy of the test results.There are many factors to affect the quality control before clinical biochemical analysis.From index selection of clinical doctors to sample being collected,being sent to examine+,being pretreatment,etc,a mistake in any link may influence test quality.The staff working at the lab should continuously improve their own comprehensive quality,strengthen contact and communication with clinic,constantly perfect the quality management system before clinical biochemical analysis,intensify management of every link before biochemical analysis,manage to improve accuracy of lab results.


— Non-linear FEM calculations are indispensable when important technical information like operating performance of a rubber component is desired. Rubber bumpers built into air-spring structures may undergo large deformations under load, which in itself shows non-linear behavior. The changing contact range between the parts and the incompressibility of the rubber increases this non-linear behavior further. The material characterization of an elastomeric component is also a demanding engineering task. In this paper a comprehensive investigation is introduced including laboratory measurements, mesh density analysis and complex finite element simulations to obtain the load-displacement curve of the chosen rubber bumper. Contact and friction effects are also taken into consideration. The aim of this research is to elaborate a FEM model which is accurate and competitive for a future shape optimization task.


Specific treatment of chronic progressive renal disease is very limited. During disease progression, extracellular matrix accumulation is the common hallmark of basically any renal process causing end-stage renal failure in man. Emerging evidence supports the concept of a major role for a thrombospondin 1 (TSP1)–TGF-b axis in scarring renal disease. TGF-b is a potent cytokine affecting growth, differentiation and gene expression [1] that apparently needs to be tightly controlled. Lack of TGF-b as demonstrated in gene-deficient mice results in a severe generalized autoinflammatory response, developmental abnormalities, increased tumorigenesis, deficient wound healing, and early death. In contrast, an excess of active TGF-b causes enhanced tumour progression, as well as progressive fibrosis in multiple organ systems and suppression of the immune system. TGF-b is secreted by most cell types as a latent, inactive procytokine complex that needs to be activated extracellularly to bind to its receptors [2]. Within the latent procytokine complex, the mature active TGF-b protein is noncovalently bound to a dimer of its N-terminal propeptide, the so-called latency-associated protein (LAP), and variably to a latent TGF-b binding protein (LTBP). In most in vitro systems or in normal tissues, very little TGF-b is present in its biologically active form. Since TGF-b protein and TGF-b receptors are widely expressed by numerous tissues and cells, the critical regulator of TGF-b-mediated action appears to be the activation process of the latent TGF-b molecule. This concept is supported by the observation that in vivo gene transfer of the constitutively active TGF-b1 gene into the lung of rats caused extensive fibrosis, while overexpression of the latent TGF-b1 transgene did not [3]. Studies demonstrated that denaturing agents such as pH changes, gamma irradiation, detergents or heat as well as reactive oxygen species, proteolysis by plasmin, calpain or cathepsin can activate TGF-b under in vitro conditions. Relatively little is known about TGF-b activation in inflammatory processes in vivo [1,2]. In an experimental pulmonary fibrosis model in mice, TGF-b activation was mediated via an integrin avb6-dependent mechanism [4] and other integrins may be involved as well [5,6]. TSP1 is a homeotrimeric multifunctional glycoprotein expressed by a variety of cell types including platelets, vascular smooth muscle cells and mesangial cells (MCs) and is frequently expressed at sites of inflammation and wound healing [7]. In vitro studies in various cell types have demonstrated multiple functions of TSP1 in modulating platelet aggregation, angiogenesis, cell proliferation, cell adhesion and migration, and TGF-b activity. As a typical matricellular protein, TSP1 is tightly regulated by cytokines such as PDGF, FGF-2 or TGF-b, and by various possible interactions with other cytokines, receptors and proteases. Its effect mainly depends on the local environment. These various biological activities of TSP1 relate to specific domains of the complex molecule including an N-terminal heparin binding region, a procollagen-like region with intermolecular disulphide bonds, three properdin-like type 1 repeats, three EGFlike type 2 repeats, a calcium-sensitive type 3 repeat, and a C-terminal globular domain. Multiple receptors such as heparin sulphate, calreticulin, LRP, CD36, avb3-integrin and CD47 as well as specific peptide sequences such the TGF-b-activating sequence RFK have been identified to be responsible for certain actions. Loss of TSP1 expression in TSP1 null mice causes a mild phenotype with predominant inflammatory lung disease [8]. The mild histological changes apparent in different organs of TSP1 null mice pups (mainly lung and pancreas) were very similar to those in TGF-b1 null mice pups [9] and could be reverted by treatment with a TSP1 corresponding peptide that activates TGF-b. Local overexpression of TSP1 in keratinocytes suppresses wound healing and granulation tissue formation in the skin of transgenic mice [10]. While the pronounced delay of wound closure in these TSP1 transgenic mice was accompanied by a Correspondence and offprint requests to: Christian Hugo, Division of Nephrology, University Erlangen-Nürnberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany. Email: email@example.com


Reducing the Risk of Endophthalmitis Following Intravitreal Injections Intravitreal injection was introduced by Ohm in 1911 as a technique to introduce air for retinal tamponade and repair of retinal detachment.1 Intravitreal administration of pharmacotherapies dates to the mid-1940s with the use of penicillin to treat endophthalmitis.2,3 Since that time, use of the intravitreal injection technique has steadily increased, with its usage being focused primarily on the treatment of retinal detachment,4,5 endophthalmitis,6,7 and cytomegalovirus (CMV) retinitis.8,9 The increasing confidence in the efficacy and safety of intravitreal injections, in conjunction with the development of additional pharmacotherapies, has led to a recent rapid increase in the use of this technique for the administration of various inhibitors of vascular endothelial growth factor (e.g., ranibizumab,10,11 pegaptanib sodium,12–15 bevacizumab16–19) for age-related macular degeneration (AMD) and diabetic retinopathy, and intravitreal triamcinolone for macular edema associated with a variety of conditions, such as diabetic retinopathy,20 central retinal vein occlusion,21 uveitis,22,23 birdshot retinochoroidopathy,24 and idiopathic cystoid macular edema.25 With the recent widespread use of this technique, there has been increased concern regarding the risk of endophthalmitis following intravitreal injection. The risk of endophthalmitis in eyes with CMV retinitis treated with intravitreal injection has been estimated to be 1.3% per eye and 0.1% per injection.26 The risk of endophthalmitis following intravitreal triamcinolone acetonide injection has been estimated to be approximately 0.8% from noninfectious causes26–28 and 0.6–0.16% from infectious etiologies.26,29 In general, endophthalmitis has been reported rarely after intravitreal injection of gas or agents other than antiviral agents and triamcinolone acetonide, with a combined prevalence of approximately 0.1% for all other compounds.26 In recent multicenter clinical trials of anti-VEGF therapy, the incidence of endophthalmitis has ranged from 0.7% to 1.6%.10,11,13,30 In two concurrent, prospective, randomized controlled clinical trials, 8/12 (67%) cases of endophthalmitis were associated with protocol violations (the most common being failure to use an eyelid speculum).14 This suggests that the injection technique is important in reducing the risk of endophthalmitis following intravitreal injection. Strategies that may be important in reducing the risk of endophthalmitis include attention to issues before, during, and after the injection. Active external infection, including significant blepharitis, should be treated before injection. In addition, eyelid abnormalities such as ectropion are reported risk factors for endophthalmitis and should be considered. Ocular surface bacteria may be the most common sources of bacteria causing postoperative endophthalmitis.31–34 Thus, one strategy to reduce the risk of endophthalmitis is to reduce or eliminate the bacteria on the patient's ocular surface and eyelids. While this may be achieved in various ways (povidone-iodine, topical antibiotics, eyelid hygiene, and sterile isolation of the surgical site), povidone-iodine is the only agent that has been demonstrated (level II evidence) to reduce the risk of postoperative endophthalmitis in a prospective study of cataract surgery.35 It is unknown whether the application of povidoneiodine in the form of drops versus a flush impacts on the ability of this agent to prevent endophthalmitis. Excessive eyelid manipulation should generally be avoided since this may be associated with a significant increase in bacterial flora (although the efficacy of lid scrubs in combination with povidone-iodine has not been reported). Reprint requests: Ingrid U. Scott, MD, MPH, Professor of Ophthalmology and Health Evaluation Sciences, Penn State College of Medicine, 500 University Drive, HU19, Hershey, PA 17033; e-mail: firstname.lastname@example.com


Brazilian researchers have used genetic breeding of cotton fibers in order to increase the production and to develop new species more appropriate to Brasil's soil and climate. Furthermore, naturally colored cotton fibers are considered potential eco-friendly materiais for textile industries because they avoid the use of synthetic pigments witch in general, contains toxical chemicals such as heavy metais. In this context, some species of colored cotton with different colors were developed by Embrapa Algodao (Paraiba, Brazil), which were denominated according to their relative colors as: beige, brown, green, "safira" and ruby. Beside the use of cotton fibers in textile industries, they have potential for application as reinforcement to polymer composites 1.3. The understanding thermal behavior of these fibers is very important because several conventional techniques used in plastic processing industry are in general, carried out in high temperature. In this study, the thermal stability of white cotton fiber and the five colored cotton fibers were compared by thermogravimetriy (TG) and derivative thermogravimetriy (OTG). The TG/OTG curves were carried out under nitrogen atmosphere (60 mL rnin"), using a platinum crucible, heating rates of 5, 10, 15 and 20°C min' and mass sample of 5.0±1.0 mg, from 25°C to 800°C. The TG data were applied to the Flynn-Wall-Ozawa method to investigate the thermal decomposition kinetics of the different cotton fibers. Figure 1 shows the thermal behavior for the studied fibers at 10°C min" (TG and OTG curves) and physical aspect of the fibers.


Aims: The aim of the study was to examine market integration and price variation in local rice marketing in Osun State, Nigeria. Specific issues addressed in the study were the determination of existence of co-integration between the rural and urban markets and the leading market between the rural and urban markets for rice. Study Design: Secondary data were used in this study. The data were sourced from Osun State Agricultural Development Programme. The average monthly retail price (/Kg) of local rice covering the period, January, 2000 to December, 2010 (11years) for Osogbo (urban market), Telemu (rural market) and Erin Ijesa (rural market) were used. Place and Duration of Study: Osun State, South-West Nigeria, between March and July 2011. Methodology: Coefficient of variation and price correlation coefficient were used to examine the behavior of local rice market price in urban and rural areas of Osun State. The Augmented Dickey-Fuller (ADF) test was used to investigate stationarity in the pairs of prices while the Johansen co-integration technique was used to determine the existence of co-integration between the markets. Results: Augmented Dicker Fuller procedure (ADF) indicated that all the variables (the individual price series for rice) were not stationary at their respective levels, but stationary


Nonlinear optical materials(NLO) have drawn a great intrest of some scholars and scientists in the last dacades because of their tremendous potential application in optoelectronic. The fabrication of efficient optoelectron devices is a challenging task because such systems need to meet the stringentable requirements for high optical quality and large and sustainable electro-optical(EO) response. In pursuit of NLO materials with excellent optoelectronic property, a number of organic and inorganic materials have been investigated. Among them, organic-inorganic hybrid materials have drawn a great interest due to their good thermal stabilities, low optical loss and convenience in fabricating their thin films. In general, dipolar second-order NLO chromophores consist of strong electron donor and acceptor substituents(D-π-A) with a π-conjugated bridge between the two. It is well established that the carefully combination of these three components showing the extremely large β values can be used to impart a necessary directional bias. Polyenes represent the most efficient π-conjugated bridge in yielding large β values. As an example, FTC[e.g. 2-dicyanomethylen-3cyano-4-(2-{E-[4-N,N-di(2-acetoxyethyl)amino] phenylene-(3,4-dibutyl)thien-5}-E-vinyl)-5,5-dimethyl-2,5-dihydrofuran] type of chromophores developed by Dalton and co-workers show βμ values larger than 18000×10 esu and thermal stability over 300 °C . Computational studies by Rao et al. and Albert et al. show that in comparison with that of benzene ring, the high electron density of thiophene could effectively enhance the electron donor ability and thus increase β values. Previous studies show that alkoxysilane functionalized chromophores crosslinked to a silica glass martrix exhibit higher poling orientation stability than the materials obtained via doping chromophores into a sol-gel matrix. So, the films containing NLO chromophores prepared by a sol-gel process may be the most potential candidates for non-linear optical materials which may retain the largest temporal behavior. To obtain sol-gel hybrid materials with large NLO responses, efforts were made to incorporate alkoxysilane NLO chromophores with large hyperpolarizabilities into the silicon matrix. In this work, a series of chromophores based on thiophene moiety was synthesized and successfully incorporated into alkoxysilanes(Scheme 1). The composite magnitude(βCTμg) of the chromophore was experimentally derived with a solvatochromic method. The synthesized chromophores and their alkoxysilane derivatives were characterized by means of H NMR, FTIR, UV-Vis, differential scanning calorimetry(DSC), thermogravimetric analyisis(TGA), EA and HPLCMS.


Various formal testing methods have been developed in the past decades. Most of them are based on graphical notations such as finite state machines, labelled transitions systems, etc., which remain quite intuitive for users to perform black box testing. In addition, testing methods based on temporal logics have been also investigated, such as the testing methods inspired by model checking. However, testing with model checkers often needs a model of System Under Test (SUT) to be known. This paper discusses a method for generating test cases from specifications expressed in CTL* temporal logic, under a black-box framework. The test generation process from CTL* is inspired by Banerjee et al.'s work [1] which has developed a technique to generate non-vacuous test scenarios from LTL properties. The essential step of our test generation method is to rewrite a pertinent CTL* property in terms of present state Boolean propositions and X(Next)-guarded temporal properties. The generated test benches are implemented within the ControlBuild tool.


Increasing the amount of plastic waste from year to year is inevitable due to the increased use of plastics by people in the World. This study aims to evaluate the mechanical behavior, in this case, the tensile strength of a hybrid composite between kenaf natural fibers, PET plastic waste and glass fibers for wallboard. This research takes the form of experimental tests in the laboratory. The composite material to be made is a mixture of plastic, kenaf fiber with glass fiber with polyester reinforcement. Both kenaf and glass fiber is made in sheet form. The hypothesis developed in this laboratory study from previous research found that kenaf and glass fiber hybrid material can be used for partition material. Results showed that hybridization with glass fiber enhanced performance properties. A value of 48,5 MPa for tensile strength is achieved from waste PET glass kenaf hybrid composite without immersion.


Construction industry remains as one of the most complex industries in Malaysia due to the many interdependent business supporting it. Currently there is no specific research done on how to integrate the entire supply chain components. This paper prepared to propose a solution to this problem. By providing a model framework for E-business Supply Chain Integrator (SCI), entire supply chain can be integrated. Hence, review of literature, initial finding, challenges and discussions on future work are highlighted in this paper.


The purpose of the present invention is to provide an organic light-emitting panel, etc., in which ink splattering in areas where banks intersect with insulation layers can be reduced, and to provide an organic light-emitting device. Pixels on this organic light-emitting panel are divided by insulation layers and banks. The insulation layers are arranged between first electrodes adjacent in a first direction, and the banks are arranged between first electrodes adjacent in a second direction. In areas of intersection with the insulation layers, the banks extend over the insulation layer in the first direction. With respect to the surface of the insulation layer, the surface of the cross-section of the banks on an insulation layer have inclination angles θ1 and θ2, which satisfy the relations θ1 > 20° and θ2 > 20°.


Acquired aplastic anemia (AAA) is an autoimmune-mediated bone marrow failure (BMF) syndrome. Cryptic clonal genetic lesions were commonly detected in a small subset of hematopoietic stem/progenitor cells (HSPCs) in most patients9 BM samples. The mechanism by which the autoimmune reaction is initiated is unknown. Whether and how these cryptic clonal genetic lesions might cause autoimmune BMF have not yet been determined. We found that mice with spontaneous deletion of the TGFβ-activated kinase-1 ( Tak1 ) gene in a small subset of HSPCs (1-3%) developed BMF which resembled the clinical manifestations of AAA patients. BMF in such mice could be reversed by depletion of CD4 + T lymphocytes or treatment with IFN-γ, suggesting a Th1 cell-mediated autoimmune mechanism. Interestingly, the disease onset and progression of BMF in such mice were significantly accelerated by inactivation of TNF-α signaling, indicating that TNF-α might restrict the progression of autoimmune BMF. Furthermore, we determined that the necroptosis of a small subset of hematopoietic cells is the cause of autoimmune BMF because such BMF can be completely prevented by deletion of Rip3 , a key necroptotic mediator. Our study suggested that the necroptosis of a small subset of hematopoietic cells induces autoimmune BMF, and that elevated TNF-α restricts the progression of such autoimmune BMF. We believe that, in addition to inhibiting T-cell-mediated autoimmune reactions to induce disease remission, repression of the necroptosis of mutant HSPCs might be necessary to prevent disease relapse and progression of autoimmune BM failure. Disclosures Stiff: Gilead: Consultancy, Honoraria, Research Funding; Incyte: Consultancy, Honoraria, Research Funding; Amgen: Research Funding; Seattle Genetics: Consultancy, Honoraria, Research Funding; Fate Therapeutics: Research Funding; Plasmacyclics: Consultancy, Honoraria, Research Funding; Eisai: Research Funding.


To define is not an activity that is foreign to philosophy. Quite the contrary: it is constitutive of much of it, and has been present from its origins. Plato, through the voice of Socrates, was basically seeking definitions: what is virtue, beauty, courage, piety, philosophy...? He did not want us to respond by a series of examples of acts, or brave or virtuous men, or beautiful works. He wanted the idea itself be presented: the very essence itself of courage or beauty. He expected a definition imposed by reality itself: the one reality, perfect, immutable, universal. Put in a different manner, Plato sought an ontological definition. These types of definitions also carry a normative scope: they express the ideal and the truth-value that sensible empirical realities cannot approach. The desire for the real, essential and necessary definition that should prevail over all can be found throughout the history of philosophy and to a certain degree in science. From Platonic idealism, this desire is perpetuated through substantialist Aristotelian essentialism, Cartesian rationalism, critical and transcendentalist Kantianism, logicism and phenomenological eideticism, etc. I have for quite a long time distanced myself from this powerful essentialist tradition, too often dogmatic, in favor of a more empiricist approach that is more widespread in European Anglo-Saxon thought than in what is called Continental (meaning for the most part French and German) philosophy. My way of


The invention relates to a novel stirring station, which comprises a skeletal material mixing cabin of which the bottom is provided with a material outlet, a material feeding system positioned below the skeletal material mixing cabin, a skeletal material weighting hopper positioned below the material feeding system, a material collecting belt conveyor positioned below the skeletal material weighting hopper, a stirring cylinder positioned below the material collecting belt conveyor, a cement storage bin, a cement spiral conveyor, a cement weighting hopper, a water pump and a water weighting hopper, wherein the stirring cylinder is simultaneously positioned below the cement weighting hopper and the water weighting hopper; the material feeding system is a variable material feeding system and comprises a variable feeding belt conveyor, a material outlet and a material door; and the structure of the stirring cylinder can be replaced according to different stirring materials.


In recent years, Thorpe analysis has been used to retrieve the characteristics of turbulence in free atmosphere from balloon-borne sensor data. However, previous studies have mainly focused on the mid-high latitude region, and this method is still rarely applied at heights above 30 km, especially above 35 km. Therefore, seven sets of upper air (>35 km) sounding data from the Changsha Sounding Station (28°12′ N, 113°05′ E), China are analyzed with Thorpe analysis in this article. It is noted that, in the troposphere, Thorpe analysis can better retrieve the turbulence distribution and the corresponding turbulence parameters. Also, because of the thicker troposphere at low latitudes, the values of the Thorpe scale LT and turbulent energy dissipation rate ε remain greater in a larger height range. In the stratosphere below the height of 35 km, the obtained ε is higher, and Thorpe analysis can only be used to analyze the characteristics of large-scale turbulence. In the stratosphere at a height of 35–40 km, because of the interference of sensor noise, Thorpe analysis can only help to retrieve the rough distribution position of large-scale turbulence, while it can hardly help with the calculation of the turbulence parameters.


International situation in rare earth is complex in recent years and rare earth in the world situation has undergone significant changes.Rare earth demand will remain strong in the world in the future and China's rare earth still has strong international competitiveness in the next two years.Strategy for the large-scale enterprise groups are an inevitable choice for raising the level of development of rare earth industry and improving the international competitiveness.Firstly,The paper tracks the new trends of development and utilization of rare earth in foreign countries,such as rare earth mine restart,new rare earth project start,new technology research and development of rare earth accelerate.Secondly,The paper analyze and conclude the situation of rare earth resources management policies in China,such as a series of new rare earth management policies were implemented,the force of exploration and planned was strengthened,the development of rare earth industry is tending to healthy,stable and sustainable.Thirdly,the paper sorts out the issues in the management and utilization of rare earth in China.The paper also analyzes the international rare earths market situation,for instance,supply and demand international situation,international competitiveness in China.Finally,the paper give some policy advices,such as development of rare earth resources in domestic and foreign simultaneously,equal stress on development and protection,joint regulation by law,improvement of environmental entry threshold for enterprise.


According to the difficult judgment problem of the single phase small current grounding in the major sampling three phase center no grounding power supply mode of the mine electric power network in China,with the references of the small current grounding line selection theory and solution of the center indirect grounding high voltage power network,in combination of the mine power network features,the SIMULINK was applied to establish the simulation model of the mine electric power network.The simulation results showed that the fault compatibility current of the fault line would be more times higher than the normal line.Based on the variation features of the line compatibility current and the traditional zero sequence power direction combined comprehensive fault line selection method,a double CPU fault line selection protection device combined with the electric power measuring DSP and the single chip processor was designed to solve the fault line selection problems of the mine low voltage network.


The SAMSI program on "Large-scale Computer Models for Environmental Systems" took place during January–June 2003. In Section 2, we summarize the main activities of the program. The remainder of the report is divided into two sections corresponding to the main breakdown of activity during the program. Section 3 is concerned with applications in the atmospheric and ocean sciences, while Section 4 is concerned with applications in porous media science.


Many systems used in HPC field have multiple accelerators on a single compute node. However, programming for multiple accelerators is more difficult than that for a single accelerator. Therefore, in this paper, we propose an OpenMP extension that allows easy programming for multiple accelerators. We extend existing OpenMP syntax to create Partitioned Global Address Space (PGAS) on separated memories of several accelerators. The feature enables users to perform programming to use multiple accelerators in ease. In performance evaluation, we implement the STREAM Triad and the HIMENO benchmarks using the proposed OpenMP extension. As a result of evaluating the performance on a compute node equipped with up to four GPUs, we confirm that the proposed OpenMP extension demonstrates sufficient performance.


ACEi are first line treatment in hypertension; however, there is controversy regarding the benefit over other antihypertensive drugs. ACEi have pressure independent effects that may make them prefe...


The goal of the article is to reveal the main tendencies of social-pedagogical interrelation of Buryatias League of young journalists during 1993-2011. Great experience of social interrelation with different partners in information society results in scientific-methodological management of children press development.


The present work describes development and validation of stability indicating HPTLC-densitometric and HPLC methods for quantitative analysis of cefepime in bulk and injection dosage form. InHPTLC, separation was performed on silica gel 60 F254 using diethylether-ethanol-water-glacial acetic acid (5: 3: 2: 0.05, v/v) as a developing system. The compact band of cefepime at Rf 0.14±0.02 was scanned densitometrically at 257nm and calibration curve was constructed in the range of 0.60-8.00 µg/spot using polynomial regression function. The proposed RP-HPLC method utilizes an isocratic elution on C18 column with mobile phase consisting ofmethanol: water (30:70, v/v) at ambient temperature and a flow rate of 1.2 ml/min. The chromatographic run timewas less than 5min. Quantificationwas achievedwithUV detection at 257nm over concentration range of 0.60 to 20.00 µg/ml. Cefepime was subjected to acid and alkaline induced hydrolytic degradation. Themethods distinctly separated it fromits degradation products, which infers the specificity of assay methods for estimation of cefepime in the presence of its hydrolytic degradation products. Due to simplicity, rapidity and accuracy of the proposed stability indicating methods, they are effective for quality control analysis.


System for producing peptides and proteins, multimeric, and applications. The system is based on a DNA construct comprising, operatively linked, at least one nucleic acid sequence (A) containing the nucleotide sequence encoding a product of interest and a nucleic acid sequence (B) It contains the nucleotide sequence encoding a tetramerization domain as the tetramerization domain of p53 protein; wherein the 3 'end of said nucleic acid sequence (A) is attached to the 5' end of said nucleic acid sequence (B). The system enables the production of products of interest, for example, multimeric peptides and recombinant proteins useful in vaccination, therapy or diagnosis, or application in industry.


Enzymatic polymerization of aniline was performed in micellar solutions of the anionic surfactant sodium dodecylbenzenesulfonate (SDBS). High-redox–potential oxidase–laccase isolated from the fungi, Trametes hirsuta, was used as a catalyst in oxidative polymerization of aniline, the atmospheric oxygen serving as an oxidizing agent. It is shown that the laccase-catalyzed reaction of monomer polymerization is kinetically controllable and its mechanism is very distinctly different from that of chemical polymerization. The synthesized PANI/SDBS complexes were characterized using Fourier transform infrared and UV–vis spectroscopy, cyclic voltammetry, termogravimetry, transmission electron microscopy, and electron diffraction. The antistatic properties of the prepared PANI/SDBS composite were also studied. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009


This study develop a model to describe the microwave emission from dry snow cover. The model is based on radiative transfer and strong fluctuation theory. In the model, the effective permittivity for a spherical symmetric correlation function with exponential form is used. The phase matrix and scattering coefficients in the radiative transfer equation for a spherical symmetric correlation function are derived by using strong fluctuation theory. The radiative transfer equations are solved by using Gaussian quadrature and eigenanalysis technique. Comparisons with literature based brightness temperature data of dry snow at 5, 10.7, 18, 37 GHz are made.


Compaction is a key issue of modern earthworks... From sustainable development, a need arise of using materials for compaction under given conditions that would normally be avoid due to unpredictable pathologies. The application of compaction on fine grained soils, without a change of gravimetric water content, lead to very important modifications of the void ratio and hence suction. Therefore the hydro-mechanical behaviour of fine grained soil need to be rendered around three variables: suction, void ratio, saturation degree or water content. The barring capacity of the soil is assessed through Penetrometers (In-situ manual penetrometer, CBR) in order to assess gains through compaction. The three states variables are then assessed for in situ and frame through water retention surfaces, realized from Proctor tests, in which compaction effect and path could be described.


16531 Background: Gemtuzumab ozogamicin is a calicheamicin-conjugated anti-CD 33 monoclonal antibody studied and utilized in relapsed and refractory acute myelogenous leukemia.

METHODS
At our center we treated a series of refractory patients (<60 years old) and relapsed patients (>60 years old) with gemtuzumab ozogamicin over a 3 year period. We treated 20 patients: 14 males and 6 females with an age range of 21 to 77 years (median 64 years). Seven patients were refractory to multiple regimens (<60 years old) and 13 were relapsing from initial therapy (>60 years old). Cytogenetic analysis revealed 60% were intermediate-risk and 40% were poor-risk. The goal of therapy was complete remission (≤ 5% leukemia blast cells in the marrow. ≥ 9 g/dl hemoglobin, ≥1500/ul absolute neutrophil count, and platelet count ≥100,000/ul). Patients received gemtuzumab ozogamicin 9 mg/m2 I.V. days 1 and 5. All patients received at least one dose. Patients achieving complete remission were eligible to receive monthly doses of gemtuzumab ozogamicin after complete remission was obtained.

RESULTS
Of the 7 refractory patients (<60 years old), there were no complete remissions. Of 13 relapsing patients (>60 years old) there were 2 complete remissions. One patient was 64 and the other 67 years old. Both remissions lasted 2 months. All patients were treated in the hospital. Chills/fever with treatment occurred in 40% of patients. Fever/neutropenia was universal. Thirty percent had elevation of liver function tests.

CONCLUSIONS
Gemtuzumab ozogamicin as a single agent is capable of producing complete remission in a small number of relapsing patients >60 years old. Remissions are short. No significant financial relationships to disclose.


ABSTRACT Artists Angélica Alomoto, Elvira Espejo and Alberto Muenala shared with María Elena Bedoya and José Luis Macas their artistic experiences and the complexities of their artistic practices in the field of art and in cultural institutions in Ecuador and Bolivia. This is only a fragment of a long collective conversation we had in the context of the pandemic of COVID 19. We would like to clarify that by saying yuyarinchik ninchik, which we could translate as 'thinking and saying together,' we exalt the process of collective dialogue that is often invisible: work meetings, readings, shared experiences and interests, etc.


Introduction/Aim: The global COVID-19 pandemic has long been considered an emergency, with the number of cases growing exponentially, despite constant efforts to control the infection. Although the disease is caused by the SARS-CoV-2 virus, most patients are treated with antibiotic therapy. The long-term effects of such broad antibiotics use on antimicrobial resistance are still unknown and are a matter for concern. The aim of this paper is: to determine, based on the available literature, the impact of the COVID-19 pandemic on the use of antibiotics; to determine the global situation regarding antimicrobial resistance; to identify key areas where urgent changes are needed. Methods: A systematic review of the current literature on the use of antibiotics in COVID-19 treatment was conducted. The PubMed and MEDLINE databases were searched for papers published between March 2020 and September 2021. Results: Between 76.8% and 87.8% of patients with COVID-19 were treated with antibiotics. Antibiotics were less frequently prescribed to children, as compared to adults (38.5%, compared to 83.4%). The most commonly administered antibiotics were fluoroquinolones (20.0%), macrolides (18.9%), b-lactam antibiotics (15.0%), and cephalosporins (15.0%). Self-medication with antibiotics to prevent and treat COVID-19 has been identified as one of the important factors contributing to antimicrobial resistance. Conclusion: The impact of COVID-19 on global antimicrobial resistance is still unknown and is likely to be unevenly distributed in the general population. Although various antibiotics have been used to treat patients with COVID-19, their role and the need for their application in the treatment of this infection remains to be determined. For now, there are no reliable data as to whether the use of antibiotics in COVID-19 cases without associated bacterial infections has any effect on the course of the disease and mortality.


The United Arab Emirates is considering an ambitious project to build a mountain that would help boost rainfall in the arid nation.


We have extended to order four in β = 1/kBT the high-temperature series expansion for the body-centred cubic phase of solid 3He with a Hamiltonian including two-, three-, and four-particle exchange. The results are used to analyze recent experimental measurements of the specific heat at low temperature and high magnetic fields.


Noise Shaping SAR (NS-SAR) ADC is an emerging architecture which can achieve power efficiency and high resolution simultaneously by combining the advantages of SAR operation and delta-sigma modulation. The prior residue process can be classified into two types: passive and active. For passive residue process, switching capacitor (SC) finite-impulse-response (FIR) filter [1] [2] is implemented with low power consumption. However, the passive approach suffers from the gain loss of charge sharing operation and the resulting NTF is mild. For active residue process, an active gain stage is implemented to compensate the gain loss and improve the NTF with a better noise suppression. However, the required amplifier for active approach is usually power consuming. Using open-loop dynamic amplifier [3] [4] is a compromised active solution for gain loss and power consumption, but, its gain is PVT sensitive and needs calibration with increasing design complexity. Closed-loop dynamic amplifier is reported to achieve a high PVT robustness [5], however, the multi-stage high-gain floating-inverter-based amplifier is needed to minimize the finite gain error with considerable settling time and power consumption requirement.


Abstract. The Kusmin-Landau and van der Corput inequalities for simple exponential sums are generalized to double exponential sums. The result are three theorems. The first theorem is a direct generalization of the Kusmin-Landau inequality. The second theorem is a mixture of both inequalities. The third theorem contains an estimation of a double exponential sum, where the domain of summation is very general. AMS Classification: 11 L 07 1. I N T R O D U C T I O N . Let /(<) be a continuously difFerentiable function in [a, 6] and let f'{i) be monotonic. Suppose that 0 < < f'(t) < 1 — Then the well-known Kusmin-Lzaidau inequality for simple exponential sums, which is important in both analysis and number theory, reads


The discussed experiment demonstrates the preservation of integrity in a prefabricated construction in the absence of visible fastening forces. It is shown that the experiment can be explained by the fact that a flow of electromagnetic energy appears within the construction. We are considering the conditions in which such flow of electromagnetic energy is maintained for an indefinite length of time.


Although lithium–polysulfur (Li–polyS) batteries employing organic polymeric sulfur as a cathode material outperform the lithium–sulfur (Li–S) battery system, the relatively low sulfur loading (<2 mg cm–2) in the current Li–polyS batteries compromises the areal capacity, constraining their practicality. We present here a new cathode active material (a covalently grafted polysulfur–graphene nanocomposite (polySGN)) for ultrahigh-loading Li–polyS batteries. The new cathode active material polySGN offers several advantages: (i) the well-dispersed graphene sheets offer highly electrically conductive pathways for electrons to travel within the polySGN matrix; (ii) the intermediate organosulfide moieties alleviate irreversible sulfide deposition on electrodes; and (iii) the in situ formed coating layer on the cathode-side surface of the polymeric separator further reduces polysulfide migration. The Li–polyS batteries employing polySGN as the cathode active material accomplish the highest sulfur loading (up to 1...


e12017Background: Oncotype DX provides prognostic and predictive information for recurrence in early stage breast cancer patients. Recently an association of Ki67 with prognosis and response have been reported. However, evidence supporting the clinical utility of Ki67 is not sufficient to recommend routine use of this marker for prognosis and prediction of responsiveness to chemotherapy in patients with newly diagnosed early stage breast cancer. We examined the relationship of IHC-measured Ki 67 to Oncotype DX recurrence score. Methods: This retrospective study included 339 consecutive cases of hormone receptor-positive, HER2 negative (T1-2 N0 M0) breast cancer. Patients were divided into low risk (Ki67 < 10%), intermediate risk (10 ≥ Ki67 < 25) and high-risk group (Ki67 ≥ 25). Results: There is high concordance rate between Oncotype DX and Ki67: 88% of the patients in the high Oncotype DX RS group had a high Ki67 score while only 4 patients (1%) of patients with Ki67 < 25 (low and intermediate risks) had...


Although the incidence of rare adverse events is difficult to measure, clinicians yearn for accurate information to better guide patient care and inform patients of potential risks. When new drugs or devices are introduced, clinician-scientists are keen to characterize the incidence of adverse events. This is an important component of the drug or device regulatory approval process. Even though the Food and Drug Administration requires a rigorous multistep process for new drug development in the United States, the process cannot evaluate all possible rare adverse events before release for widespread use. To do this would require large sample sizes and be cost prohibitive. This is why "Phase IV" or postmarketing assessment of safety is necessary and may even be required for ongoing approval. A clear picture of a new drug's safety emerges only after months if not years of clinical use. This process has been enabled in the Information Age by the advent of large collections of granular patient data, and the tools to query them. In this month's issue of Anesthesia & Analgesia, Burbridge1 describes the incidence of anaphylaxis to sugammadex in a single-center cohort of nearly 20 thousand patients, captured from the institution's electronic medical record. He reports an incidence of 1 in 9910. This is in stark contrast to previously reported rates. For example, the sugammadex package insert reports a rate of 1 in 300 as described by Min et al.2 In a prior retrospective large cohort study, Miyazaki et al3 reported a rate of 1 in 2500. Which of these widely different numbers should we believe? Although estimates from each study were reported in reputable journals with rigorous peer review, at face value, the range in anaphylaxis rates is too large to be of clinical use in estimating the rate of an adverse event. As is common in clinical research, the reason lies in the methodology of the individual studies: in this case, how the diagnosis of anaphylaxis was established. To better understand how investigators arrived at these very different rates, a brief review of each study's design reveals significant differences and limitations in the methods used. For the data presented in the sugammadex package insert, Min et al2 utilized a prospective placebocontrolled volunteer study. Their design used 3 groups of volunteers. One group (n = 151 volunteers) received sugammadex 4 mg/kg (a dose used to reverse deep neuromuscular blockade). A second group (n = 148 volunteers) received sugammadex 16 mg/kg (a dose used to reverse profound neuromuscular blockade). A third group received a placebo. Only 1 subject, in the 16 mg/kg group, exhibited signs of anaphylaxis according to the Sampson criteria developed by the National Institute of Allergy and Infectious Diseases.4 To estimate a rate of anaphylaxis, the authors summed up the total number of volunteers that received either dose of sugammadex to generate the rate of 1 in 299 or 0.3%. Positive features of this experimental design include that (1) it was prospective and enrolled healthy volunteers; (2) doses were more than what is routinely used for reversal of neuromuscular blockade; (3) each volunteer received repeated doses of sugammadex to explore the influence of prior exposure as a source of sensitization; and (4) the authors used published criteria to perform a rigorous assessment of the timing of anaphylaxis onset, skin and mucosal Chasing Shadows, Catching Smoke, and Estimating Anaphylaxis to Sugammadex


The prevalence and diversity of female ornaments poses a challenge to evolutionary theory because males should prefer mates that spend resources on offspring rather than ornaments. Among dance flies, there is extraordinary variation in sexual dimorphism. Females of many species have conspicuous ornaments (leg scales and inflatable abdominal sacs). Meanwhile males of some species have regions of their eyes with larger ommatidial facets, common traits in many arthropod taxa that allow for regionally elevated photosensitivity and/or acuity. Here, we conduct a comparative study of these traits using both species descriptions available from the literature, as well as quantitative measures of eyes and ornaments from wild-caught flies. We show a conspicuous covariance between exaggerated male dorsal eye regions and the extent of female ornaments: species with highly ornamented females have males with more exaggerated eyes. We discuss this pattern in the context of competing hypotheses for their evolution.


This letter proposes a novel up-conversion mixer with pseudo-differential and current-reused topology in 90 nm CMOS technology. The proposed source-pumped up-conversion mixer can operate at near weak inversion under a power consumption of 149 μW from a 0.4 V supply voltage while maintains acceptable circuit performance at millimeter-wave (MMW) frequencies. Measurement results show that the up-conversion mixer exhibits a -0.62 dB conversion gain (CG) and a -4 dBm OIP3. An achieved figure-of-merit (FoM) is 1.46.


SUMMARY
Symptom production was recorded during a 31 month period in a commercial crop of carnations infected by Fusarium oxysporum f. dianthi. In the first year spread was slow but increased to approximately 12 in. (0·305 m) of bed length per month by the end of the crop.

The degree of infection and colonization of the plants did not differ greatly at 18–20°C or 23–25°C, although symptoms appeared more rapidly at the higher temperature.

Benomyl, applied as a drench to each plant at the rate of 1·5 g and 3·0 g/4·5 l./200 ml. suppressed symptom expression and was not markedly phytotoxic. Best results were obtained when the fungicide was applied within a week of planting into infested soil. Bioassay results of treated plants indicated a maximum level of activity within the plant 10–14 days after application.


The objective of this communication was to point to the current situation of the development of the rabbit industry in Egypt by using specifically selected lines. A brief of the historical background of the local Egyptian rabbit lines and the establishment process of the distinguished new lines was mentioned in the manuscript. Three specialized rabbit lines were established and improved through genetic programs in Egypt during the last two decades. One paternal line (Alexandria), one maternal line (APRI) and one global objective line (Moshtohor) were developed in the framework of an Egyptian-Spanish project to develop specific rabbit lines in Egypt. The performance of these specialized selected rabbit lines in different traits was characterized in many papers. A spot on the development of theses lines and their current performance is considered to present in this communication


One hundred and eight Charolais cross steers were used to compare forage versus grain feeding as affected by slaughter endpoint on carcass composition and palatability attributes of beef. Diets included a 97% alfalfa silage ration or 68% high moisture corn, 25% alfalfa silage ration from start of test to finish or a ration of 97% alfalfa silage from start of test to day 42 of the trial followed by the 68% high moisture corn ration until slaughter. Cattle were slaughtered at either 4, 7, or 10 mm ultrasound backfat. Grain feeding increased (P = 0.01) average daily gain and decreased (P = 0.01) days to finish, while carcass weight and grade fat were similar (P > 0.10) between diets. Palatability attributes were generally unaffected by diet with the exception of slightly less (P = 0.09) beef flavour and more (P = 0.01) off flavour in forage-fed beef versus grain-fed beef. Higher (P = 0.01) concentrations of linolenic acid and lower (P = 0.09) concentrations of oleic acid in forage-fed beef may be partially r...


In 12—15 July 2002,the eastern of Liaoning Province was hit by cold vortex precipitation and hails.In order to analyze the cloud microphysical processes, we used a three-dimensional convective cloud model developed by IAP to simulate this event.According to simulations, the cloud system which produced the precipitation was the convective-stratiform mixed clouds.The mechanisms of ice particles melting played a main role in cloud and precipitation formation,especially graupels melting accounted for about 50% of total rainwater production.Through a series of the modeling calculations of AgI-seeding,we found that the optimal time of AgI-seeding cloud was at the cloud mature stage and the seeding height should be above the 0℃ layer.Simulations also show that the convective-stratiform mixed clouds have a considerably seeding potential to enhance precipitation.


A major problem in extragalactic astronomy is the inability to distinguish in a robust, physical, and model-independent way how galaxy populations are physically related to each other and to their formation histories. A similar, but distinct, and also long-standing question is whether the structural appearances of galaxies, as seen through their stellar light distributions, contain enough physical information to offer this classification. We argue through the use of 240 images of nearby galaxies that three model-independent parameters measured on a single galaxy image reveal its major ongoing and past formation modes and can be used as a robust classification system. These parameters quantitatively measure: the concentration (C), asymmetry (A), and clumpiness (S) of a galaxy's stellar light distribution. When combined into a three-dimensional "CAS" volume all major classes of galaxies in various phases of evolution are cleanly distinguished. We argue that these three parameters correlate with important modes of galaxy evolution: star formation and major merging activity. This is argued through the strong correlation of Hα equivalent width and broadband colors with the clumpiness parameter S, the uniquely large asymmetries of 66 galaxies undergoing mergers, and the correlation of bulge to total light ratios, and stellar masses, with the concentration index. As an obvious goal is to use this system at high redshifts to trace evolution, we demonstrate that these parameters can be measured, within a reasonable and quantifiable uncertainty with available data out to z ∼ 3 using the Hubble Space Telescope GOODS ACS and Hubble Deep Field images.


Abstract : The International Civil Aviation Organization (ICAO) has proposed the adoption of a standard international heliport beacon. This beacon consists of a white strobe light coded to display a sequence of four flashes that signify the Morse code letter 'H'. For evaluation purposes, the proposed strobe beacon was compared to the United States standard three-color rotating beacon. Pilots completed post-flight questionnaires after viewing both beacons. Without any clear-cut choice U to which beacon was the best, pilot responses indicated that both beacons provide adequate guidance in locating a heliport. From these results, we conclude that there does not appear to be reasonable cause for opposing adoption of the proposed strobe beacon as an ICAO standard. Furthermore, there does not appear to be any compelling reason to change the present United States standard for heliport identification beacons at this time.


Introduction Bipolar disorder is characterized with recurrent manic and depressive episodes with interepisodic remission periods. The course of illness including frequency and severity of mood episodes are the most evident changes at geriatric ages in bipolar disorders. Objectives With this background, we aim to evaluate the clinical variables of bipolar patients older than 60 years and compare clinical variables before and after this age. Methods Bipolar patients who applied to psychiatry outpatient unit in Çanakkale 18 Mart University Medical Faculty between the years of 2017-2022 were evaluated retrospectively. Patients over the age of 60 were included in the study. 47 out of 133 people over the age of 60 with bipolar disorder were not included in the study due to lack of information. Socio-demographic data of 85 patients recruited for the study, and clinical variables of the patients before and after the age of 60 were compared with Wilcoxon test. SPSS 26 version was used for statistical analysis and p<0.05 was considered as significance level. Results When we evaluate the sociodemographic variables of the patients, we found that 61.2% (n=52) of the patients were female, mean age was 67.6± 6.3 years and mean duration of education was 7.2±4.6 years. Most of the patients (76.5%, n=65) was diagnosed with bipolar disorder type 1 (BP1) while nearly one four of them (24.7%) had a mood disorder history among their relatives. Median of the illness duration was 19.5 years (min:2, max:60), mean age of the first episode was 43.6±14.3 years and more than half had their first episode as depression (56.5%, n=48). When we compare the number of episodes, number and duration hospitalizations before and after the age of 60 years, we found that number of depressive (p=0.001,z:-3.3), (hypo)manic (p=0.001,z:-3.3), episodes and number of hospitalizations (p<0.001,z:-3.8), were lower at geriatric ages. However, there was no difference before and after the age of 60 years in terms of duration of hospitalization. Conclusions Course of illness in bipolar disorder is highly variable and recurrence of mood episodes may increase with age (van der Markt A et al . Int J Geriatr Psychiatry. 2022;3;37(11), Dols A et al, The clinical course of late-life bipolar disorder, looking back and forward. 2017 Dec 11). However, in our study we found that number of depressive, (hypo)manic episodes and number of hospitalizations were lower at geriatric ages. This discrepancy may be related with sample selection and study design. Nevertheless, it should be taken into account for further studies. Besides, this is not a mirror image study and duration of follow-up periods were not considered for the statistical analysis. These are the additional limitation of our study. It is difficult to make further interpretations considering these limitations. Prospective follow-up studies with large sample size are required to better understand the course of bipolar disorder at geriatric ages. Disclosure of Interest None Declared


With the increased interest in healthy eating and diet control, the importance of keeping track of daily calorie intake is an important topic nowadays. In this paper, we propose a novel technique to automatically calculate calories based on the picture of various foods on a plate. As a first step, this paper concentrate on food plates with fruit and vegetable content only. A new dataset was developed internally for this research consisting of a total of 41,509 images. In this paper, we propose a Deep Convolutional Neural Network (DCNN) for the automatic recognition process. A custom design application was developed for capturing the image, recognition, and automatic calculation of calories. The results showed that over 92% recognition rates were achieved on most fruits and vegetables.