The present study is a continuation of our experiments on methylmercury–cysteine (MeHg–cysteine) uptake by rat red blood cells (RBCs) at low temperature. Methylmercury–cysteine uptake by rat RBCs was conducted at 5°C and 20°C. The effects of Ca2+, colchicine, cytochalasin B, 4,4′‐diisothiocyano‐2,2′‐stilbenedisulphonic acid (DIDS), N‐ethylmaleimide (NEM),d‐glucose, hexanol,l‐homocysteine, ouabain, probenecid, sodium fluoride (NaF), vinblastine, and anisotonic changes on MeHg–cysteine uptake were examined. The results showed that MeHg–cysteine uptake at 5°C could be described by Michaelis–Menten kinetics (v = VmaxS/(S + Km), where Km = 37.02 mM and Vmax = 320.84 mmol l−1 RBCs h−1), but MeHg–cysteine uptake at 20°C could be described by Michaelis–Menten kinetics with a linear component (v = [VmaxS/(S + Km)] + KdS, where Km = 2.71 mM, Vmax = 250.72 mmol l−1 RBCs h−1, and Kd = 5.63 mM). Methylmercury–cysteine uptake was inhibited by colchicine, cytochalasin B,d‐glucose, hexanol, NaF, NEM, ouabain, probenecid, vinblastine and 230 mosM hypotonicity but stimulated by Ca2+, DIDS,l‐homocysteine and 460 mosM hypertonicity. The results in the present study suggest that MeHg–cysteine uptake by rat RBCs might be involved in the following three transport systems: an energy transport system sensitive to Ca2+, ouabain and NaF and subjected to Michaelis–Menten kinetics; an organic anion transport system sensitive to probenecid; and a facilitated diffusive transport ford‐glucose sensitive to cytochalasin B. It is likely that most of the transport systems work at temperatures higher than 5°C.


An ultra-low power consumption SoC integrated with the power management unit that used for edge computing is present in this paper. The Rocket Core that bases on low power open-source hardware instruction set RISC-V is used as the core in the SoC, and open source deep learning accelerator NVDLA is integrated into the SoC. Besides, rich peripheral interfaces are integrated to meet the most demands for IoT applications. To analyze and evaluate the power feature, the proposed SoC is synthesized in SMIC 40nm LP CMOS technology; and some applications are run on this SoC to estimate the power consumption.


Comprising: forming an insulating layer (201) on a substrate (120a), the first mask material (203) corresponding to the step of applying a first color pixel region on the insulating layer (201), the second mask material (203) corresponding to the step of applying the second color pixel region on the insulating layer (201), using the first mask material on the second insulating layer (201) patterned and formed in different respective grating pitch 1 the diffraction grating and the second diffraction grating (115) step, wherein: applying the first and second mask material by selecting a coating method.


The most important natural resource which cannot be optimally used and sustained unless its quality is properly assessed, is groundwater. In the present study, the physicochemical variations of groundwater from the area of an chemical platform were determinate. The physicochemical parameters determined for the groundwater were evaluated by comparing the results obtained with the the limits allowed under current legislation. For this study were examining 16 drillings for a period of five years. Water samples were collected quarterly from each sampling point in the study. The physico-chemical quality indicators analyzed for each source were: pH, chlorides, sulfates, bicarbonates, carbonates, sodium, calcium, magnesium, ammonium, filterable residue, suspended matter, mercury and CCO-Mn.Interpretation of physicochemical data revealed that groundwaters studied was neutral to slightly alkaline. The cations such as sodium (Na+) for all groundwaters studied it was in general found above the limit imposed under the laws in vigor in almost all studied drillings except drillings generally located upstream of the industrial platform. The anions such as chlorides (Cl-) exceeded, in general, the limit allowed under current legislation. The filterable residue concentration was observed in all the studied drillings and the parameter such as sulfate (SO42-), were within the limit allowed under current legislation for the most all studied drillings, for the whole period investigated. In general, the sulfate quality indicator exceeds the required limit, for drilling located downstream and in vicinity of the chemical platform.

http://bch.ro/pdfRC/21 POPESCU L. R. 10 18.pdf


Oxidative stress, as a consequence of the elevated reactive oxygen species (ROS), has been implicated in various chronic diseases including cancers by, for examples, causing oxidative DNA damage and altering epigenetic regulation. Long interspersed element-1 (LINE-1) is an only active retrotransposable elements in human DNA, comprising up to 17% of the whole genome. LINE-1 hypomethylation is reported in bladder cancer and evidently it is a consequence of oxidative stress. In this study, we investigated the expression of 5-methylcytosine (5-mC), 8-hydroxydeoxyguanosine (8-OHdG), LINE-1-endoced protein (ORF1p), histone H3K9me3 and HP1 alpha?in bladder cancer tissues. Mechanistic insight into how oxidative stress affected DNA methylation and histone modifications that further caused aberrant expression of LINE-1 elements in bladder cancer cells was also explored. Elevated expression of 8-OHdG, decreased 5-mC expression, upregulation of ORF1p expression, and increase in histone H3K9me3 expression were observed in bladder cancer tissues, indicating increases in oxidative stress and epigenetic alterations. The in vitro study in bladder cancer cell lines revealed that LINE-1 hypomethylation was occurred through the oxidative DNA damage on LINE-1 promoter. Based on ChIP experiments, oxidative stress disturbed histone modification patterns, especially on LINE-1 promoter. Enrichments of histone H3K4me3 and H3K18Ac at LINE-1 promoter were increased in ROS-treated cells compared to the untreated control. In addition, ROS-treated bladder cancer cells had migration and invasion capability greater than the untreated control cells. In conclusion, elevated formation of oxidative DNA lesions, overexpression of ORF1p, and alteration of chromatin modification were shown in human bladder cancer tissues. Experimentally, oxidative stress induced by ROS caused hypomethylation of LINE-1 and enrichment of active chromatin marks at LINE-1 promoter. These, at least in part, led to increased expression of LINE-1 ORF1p protein. The current findings suggest that LINE-1 reactivation by oxidative stress promotes bladder cancer progression. Therefore, downregulation of LINE-1 expression and attenuation of oxidative stress could be potential targets for bladder cancer therapy in the future.


Purpose Little is known about the mental health of the Hakka elderly. This study explores the status of, and factors associated with mental health among Hakka elderly populations from Fujian, China. Methods This is a cross-sectional, community-based survey study containing a total of 1,262 valid samples. The Chinese version Symptom Checklist-90-R (SCL-90-R) was used to assess the mental health status of the Hakka elderly. We used t-tests to compare the differences for 10 dimensions of SCL-90-R scores between the Chinese national norm and the Hakka elderly. Univariate and multivariate analysis were performed by using linear regression analysis to identify the main socio-demographic factors that were most predictive of the total score of SCL-90-R in the Hakka elderly. Results The scores of somatization (1.78 ± 0.55 vs. 1.40 ± 0.46, P < 0.001) and phobic anxiety (1.21 ± 0.36 vs. 1.17 ± 0.31, P < 0.001) for the Hakka elderly in Fujian appeared to be significantly higher than the Chinese norm. The higher total scores of SCL-90-R were found among females (β = 0.030, P = 0.044), widowed persons (β = 0.053, P = 0.021), those with parent(s) alive (β = 0.047, P = 0.019), and those with poorer self-rated health status (β = 0.110, P < 0.001). The lower total scores of SCL-90-R were found among those who were currently living in town, those with lower education level, those with higher average annual household incomes, and those who were living with spouse or children. Conclusion The worse mental health conditions of the Hakka elderly in somatization and phobic anxiety were detected. The overall mental health status was shown to be worse among females, widowed persons, those who were living in village, those with lower education, and those with father or/and mother alive.


J R Bessant, J A E Bowen, K E Dickson and J Marsh 1981 London: Frances Pinter 174 pp price £13.75 The aim of this book, says the jacket blurb, is 'to help the reader find his or her bearings in the jungle of facts and opinions which form the ingredients of the microelectronics debate, and to serve as a guide to the extensive and widely varied literature on the subject'. So, it has a partly annotated bibliography of books, reports and papers and a 130 page 'review' of these references covering the technical aspects of micros and their possible applications, as well as their likely impact on manufacturing industry, the office, and telecommunications.


A 76-year-old woman presented with a one-year history of intermittent right lower abdominal pain, little weight loss, and palpable mass in the right lower quadrant of the abdomen. Pelvic ultrasound scan identified a lobulated hypo-hetero-echoic mass with some calcified foci. Computed tomography scan revealed a low-attenuated lesion-like mass in the perineal region, which suggested a cystic localized tumor. Colonoscopy showed sub-mucosal lesion in the cecum. The patient underwent Laparotomy, and a right hemicolectomy (include ileum) with ileocolic anastomosis was performed. She was treated successfully. In the Histological examination, two mass-like lesions were found to attach to the appendix. In the proximal portion of the appendix, there were cystic structures that showed a low-grade appendiceal mucinous neoplasm. The tip of the appendix showed a well-differentiated neuroendocrine tumor (carcinoid tumor). In this unusual case, even though the initial origins of these two tumors are quite different, two tumors appeared in a single histological section.


Trace metals with sewage and sludge particulates from the City of Los Angeles Hyperion Treatment Plant are found to mobilize to a great extent from solids to seawater in the ocean environment. The fate of these metals and the amount of annual transport to the ocean are evaluated, based on: (1) Concentrations of trace metals in the wastewater particulates; (2) sediment metal concentrations in the proximity of sewer outfalls; (3) the degree of metal release from wastewater particulates upon mixing and dilution with seawater under laboratory conditions; and (4) the settling velocity of sewage and sludge particulates. More than 90 percent of trace metals, such as cadmium, copper, lead, nickel, and zinc in the sludge particulates are solubilized through biochemical reactions. A higher degree of solubilization from the mixture of primary and secondary effluents is observed.


Urinary reflux needs careful evaluation and prompt treatment. Presenting complaints include failure to thrive, and/or recurrence of a urinary tract infection. If bladder outlet obstruction is present,


................................................................................................................................ i Acknowledgments ............................................................................................................... iii LIST OF TABLES ..................................................................................................................... ix LIST OF FIGURES ................................................................................................................... xi CHAPTER 1: INTRODUCTION ............................................................................................... 1 Aims and Objectives: ....................................................................................................... 3 CHAPTER 2: BACKGROUND .................................................................................................. 5 GEOLOGIC HISTORY OF MOUNT HOOD ............................................................................... 5 Prehistory: ........................................................................................................................ 6 Polallie Eruptive Period: ................................................................................................... 6 Timberline Eruptive Period: ............................................................................................. 8 Zigzag Eruptive Period: .................................................................................................. 10 Old Maid Eruptive Period: ............................................................................................. 10 Recent Geologic History: ............................................................................................... 12 Summary: ....................................................................................................................... 16 PREVIOUS DEBRIS FLOW RESEARCH .................................................................................. 17 CHAPTER 3: METHODS ....................................................................................................... 22 Field Methods: ............................................................................................................... 22 v Initial Reconnaissance:............................................................................................... 22 Detailed Mapping of the Initiation Zone: .................................................................. 26 Sample Collection ...................................................................................................... 27 Data Processing: ............................................................................................................ 29 Laboratory Sieve Analysis: ......................................................................................... 29 Rainfall Data ............................................................................................................... 30 Drainage Basin Attributes: ......................................................................................... 32 CHAPTER 4: RESULTS .................................................................................................... 40 INTRODUCTION .............................................................................................................. 40 ELIOT CREEK DRAINAGE BASIN: ..................................................................................... 41 Reconnaissance & Sample Collection: ....................................................................... 41 Data Processing:......................................................................................................... 47 SANDY RIVER DRAINAGE BASIN: .................................................................................... 49 Reconnaissance & Sample Collection: ....................................................................... 50 Data Processing:......................................................................................................... 55 WHITE RIVER DRAINAGE BASIN: .................................................................................... 57 Reconnaissance & Sample Collection: ....................................................................... 58 Data Processing:......................................................................................................... 61 NEWTON CREEK DRAINAGE BASIN: ............................................................................... 62


The preparation of ketorolac tromethamine alginate-chitosan microcapsules was optimized by uniform design and non-linear programming using entrapment efficiency and drug loading as evaluation parameters. The results showed that entrapment efficiency and drug loading of the product prepared by the optimized conditions were 90% and 44%, respectively. The in vitro release behavior in water could be described by Higuchi equation.


A colony of  Platythyrea arnoldi  was found to contain a functional queen and laying workers, both virgin and mated. This form of social organization has never been reported in ants before.


Abstract A total of 222 specimens from 55 populations of short-necked chelid turtle was collected from drainages in Australia and Papua New Guinea. Two populations were initially considered to belong to different diagnosable taxa if all individuals in one population could be distinguished from all individuals in the other by fixed allozyme differences. When two populations or diagnosable taxa shared allozymes at all presumptive loci, their profiles were combined into a single diagnosable taxon. Comparisons between populations and emerging diagnosable taxa were repeated until no further changes were possible. The species Elseya dentata comprised five clearly diagnosable taxa, differing by between 4 and 19 fixed allozyme differences. The currently recognized El. latisternum and El. novaeguineae were each a single diagnosable taxon, and there were three diagnosable taxa, including a sibling pair, that could not be assigned to a currently described Elseya species. In contrast, all forms of Emydura were very closely related, with no two taxa differing by more than three fixed allozyme differences. There were three diagnosable taxa in the north ( Em. victoriae, Em. subglobosa and one new form), though support for them was marginal. In the south, Em. macquarii, Em. krefftii and Em. signata formed only a single diagnosable taxon, even sharing rare alleles. If the phylogenetic species concept is adopted, there is support for recognition of 16 species of short-necked turtle in Australia, including Pseudemydura umbrina . Currently only 10 are described. Our data also provide evidence of reproductive isolation in some cases (sympatric or parapatric), and comparative evidence ( sensu Mayr) in others, than the traditional biological species concept applies also to these diagnosable taxa.


Photometric data were used to perform the first light curve analysis of the V0610 Vir binary system. We extracted the minima from our observations and compiled the literature, which was few in number. Therefore, we performed computations using the reference ephemeris and presented a new ephemeris and O-C diagram with a linear fit. Light curve analysis was performed using the PHOEBE Python code and the Markov chain Monte Carlo (MCMC) approach. The assumption of a cold spot was required due to the asymmetry in the light curve's maxima. The analysis shows that V0610 Vir is a contact binary system with a fillout factor of 0.085, a mass ratio of 0.998, and an inclination of 70.65deg. The absolute parameters of the system were estimated based on the Gaia DR3 parallax method. The results show that the system is a Low-Mass Contact Binary (LMCB) with a total mass lower than 0.8(M_Sun). The location of the stars was shown in the M-L and M-R diagrams.


Plumeria rubra L. is a rustic and small tree with 4-8 meters high with thick and smooth stems, dark green leaves and large flowers exuding a pleasant fragrance, similar to those of Jasminun sp. (Lamiales: Oleaceae). This plant is native to Central America but it was also introduced to most tropical and subtropical regions of the world in gardens, streets and used to prepare necklaces and in Medicine. The objective of this study was to identify a Lepidoptera defoliator of P. rubra at the Federal University of Viçosa in Viçosa, Minas Gerais State, Brazil. This insect was identified as Pseudosphinx tetrio (Linnaeus, 1771) (Lepidoptera: Saturniidae). Its caterpillars have black body with yellow rings, covered with bristles thoracic, and abdominal prolegs are orange . Its length can reach 6 cm and it has a black and characteristic spiniform process on the back of the eighth tergo. Adult are large and gray with black transverse stripes and wingspan from12.7 to 14.0 cm. Females are usually larger than males and lighter in color. Pseudosphinx tetrio should be included in monitoring programs of P. rubra pests.


A new and simple method is described for obtaining several primitive pentanomials over GF (2) from primitive trinomials of the same order. It is shown that for a given n-th order primitive trinomial f(x)=xn+xp+1 we can easily obtain some of the primitive pentanomials of n-th order, if there exists an integer r such that for s=2m+1 (m: integer), (1) p=rs or (2) n=rs or (3) n-p=rs. All the primitive pentanomials of up to 1,000 degree obtained by this method are shown in the table. Keyword: M-sequence, pseudo-random sequence, GF (2), primitive polynomial


The Mediterranean Sea orginated at the beginning of the Tertiary as a result of a connection between the Tethys and the Atlantic Ocean. The Tethys was a comparatively shallow inland sea, which occupied the Central Asiatic area during most of the Mesozoic. At the beginning of the Tertiary the Tethys became gradually smaller because of the intensive evaporation under an arid or semi-arid climate and it shifted in western direction because of movements of the Earth's surface. Thus the Tethys strongly decreased in its Aiiatic part (where the Aral Sea and the Caspian Sea still remain as its major relicts) and expanded westwards occupying the present site of the Mediterranean Sea. Our knowledge of the flora which originated around the Tethys is based principally on the recent chorology. It was a continental flora with Indo-Malayan affinities and its relicts are preserved in the arid parts of Western Asia. The Atlantic Ocean originated at the end of the Paleozoic with the break-up of Gondwanaland. In the Tertiary the definitive separation between North America and Eurasia occurred and the Atlantic Ocean occupied its present site. The flora which originated around the Atlantic had an oceanic character and shhwed Patagonian affinities. Its relicts are chiefly preserved in the Canary Islands (Macaronesia). When Tethysian and Atlantic waters reached each other also their floras began to mix. The Tertiary flora of the Mediterranean Basin (Braun-Blanquet 1923) shows subtropical characters in a predominance of evergreen woody


The fierce competition in the global silk market encourages the development and application of new biotechnologies in sericulture, such as cloning. The term "clone" in Greek means "branch". A clone is an offspring of a single organism propagated without fertilization. All cloned individuals are genetically identical and are copies of each other. Clones are obtained in different ways. In case of the silkworm, this is a parthenogenetic development, which is an unnatural way of reproduction for the silkworm. Thermoactivation of an unfertilized greene at t0=46 0C during 18, leads to inhibition of the reduction division of meiosis in the silkworm germ cells. As a result, the eggs remain with a diploid set of chromosomes and develop as zygotes. Since the female cells in the sex chromosomes of the silkworm are heterogametic, only female parthenogenetic clones develop from thermally activated eggs. This feature makes silkworm clones extremely attractive for creating 100% pure hybrids. As the sericulture globally is based on the production of hybrids of the first generation only, in order to use maximum heterosis, the accuracy of preparation of hybrids is becoming particularly important.


This diploma work is focused on the analysis of the negative effects of transport on the environment. The work defines the term "sustainable development in traffic conditions". The work also deals with the possibility of alternative fuels that could be used in the Czech Republic. Furthermore the work contains a description of the methods for a multi-criteria decision making process. This method is used to select the currently most appropriate types of fuels.


The research was supported by the Russian Foundation for Basic Research, project № 18-512-18006 Болг_а
«Migration of the texts in cultural area of the Slavia Orthodoxa».


Biological samples are of great interest for many imaging techniques. The samples usually contain small structures and weak absorption properties. The combinations of weak signals with overlying structures make feature recognition difficult in many cases. In the x‐ray regime, a relatively new imaging technique Diffraction Enhanced Imaging (DEI) has superior tissue contrast over conventional radiography and is proven to be very sensitive method. Multiple images taken by DEI are called Multiple Image Radiography (MIR). The purpose of this study is to validate the potential application of the method and to show that MIR‐DEI method may give more information about the sample.


It discloses a method for aligning an ophthalmic measuring apparatus measuring optical system and the eye examination subject eye light source for illuminating the eye with an outer lighting system. When detecting the reflected images of the cornea of the eye illuminated by a light source aligned with the object, the optical alignment system in accordance with measurement of the cornea reflected image. When the alignment is not detected when the reflected cornea image of the source, detecting the reflected cornea image formed by the outer eye light source, the reflected cornea image formed by the alignment light source extraocular measuring optical system. Thereafter, the reflected cornea image is detected again.


Described is a new National Institutes of Health supported Molecular Biology Computer Research Resource located at the Dana-Farber Cancer Institute in association with Harvard Dniversity, Boston, Massachusetts. IHTRODOCTIOH The National Institutes of Health, Division of Research Resources has awarded a 5 year grant to the Dana-Farber Cancer Institute, Harvard School of Public Health and Harvard Medical School to establish a aolecular biology computer resource coupled with a genetic sequence pattern recognition program. This Molecular Biology Computer Research Resource, the MBCRR, has two aijor collaborative objectives. The first is research in the development of statistical and computer aethods that can reveal syntactic and semantic patterns in DMA, RM1, and protein sequences--aost of which are still obscure or unknown. The other is to support a research resource to use such aetbods-developed in the course of this project as well as others--to discover patterns that trace evolution and that are involved in the regulation of gene expression. The identification of such sequences should provoke the formulation and testing of anjor hypotheses in aolecular evolution, gene regulation and developmental gonetics. Teaple F. Smith of the Harvard School of Public Health is the director of the MBCRR. Co-principal investigators with Salth are Allan M. Mazaa of Harvard Medical School and Harcello Pagano of the Harvard School of Public Health . Other MBCRR staff are Susan Tolaan, User Coordinator*, Donald V. Faulkner and Ronald Keaaan, Application Prograaaers. Allan Maiaa was responsible for initially bringing data basss and software of interest to the local aolecular biology community at the Harvard Medical * Karen Oruskin who was instrumental in the start of the MBCRR has left as user coordinator to continue her education, but reaains a consultant. © IRL Preu Limited, Oxford, England. 25 Nucleic Acids Research School four years ago. This acted as a pilot program for the MBCRR proposal to the HIH. The HBCRR has been organized to eiploit the advantages of coupling active basic genetic research directly with computer software development. This is to be accomplished by encouraging collaborative interactions between active researchers who have new or unsolved analysis problems and computer scientists and software developers. COMPOTER RESOURCE The HBCRR provides nuaerous DMA, RHA, and protein sequence analysis tools to investigators in the greater Boston area on-line and to the research community at large by downloading or on magnetic media The HBCRR maintains a number of data bases on-line and is in the process of obtaining access to others. Currently included are nucleic arid sequence data bases GenBank and EHBL (European Molecular Biology Laboratory), the KBRF (Hational Biomedical Research Foundation) protein sequence data base, the Kabat "Proteins of Immunological Interest" data base, the Cold Spring Harbor Restriction Enzyme data base and the IntelliGenetics cloning vector data base In addition thr HBCRR is working to make available some of the biological data bases not yet accessible and to provide a system to enable cross referencing with the current sequence data. » front end (in FORTRAH77 and "C") has been developed allowing access to the data base which may be added to most software. The HBCRR has developed a utility to reformat and subdivide (important For small computer systems) the original GenBank releases into user defined files. Hith the rapidly expanding data base size and large number of alternate analysis programs, the MBCRR has written utilities to browse through on-line documentation, help files and program example run files and data base directories. All such developed tools are freely available. TRAIHIHC The HBCRR provides training/research opportunities at three levels. First there is introductory level training in the use of available software (including BioHet (1) software) at the Dana-Farber Cancer Institute. This introduction is generally used only by local area users, but is available to any researcher visiting the area. Second, more extensive training with collaborative research opportunities will begin in April 1986 with visiting scientist positions available for one to three months. These positions are designed to give hands-on computer software experience to molecular biologists who have current research projects requiring computer analysis. The MBCRR


BACKGROUND: Renewed concern over the adverse impacts of nutrients on the quality of surface waters prompted drafting of the Vice President's Clean Water Action Plan (Browner and Glickman 1998) and led to the design of the EPA's national strategy for the development of regional nutrient criteria for major classes of water bodies, including rivers and streams, lakes and reservoirs, wetlands, and estuaries and coastal waters (U.S. Environmental Protection Agency 1998). Development of such a strategy is founded on the well-established relationship between plant nutrients, particularly phosphorus and nitrogen, and water resource impairment (e.g., National Academy of Sciences (1969)). Implicit in the strategy is the importance of the linkage between nutrient sources in the watershed and resultant concentrations in receiving waters. The strategy is clearly intended to limit or reduce water quality problems related to nutrient overenrichment from the watershed. Once developed, nutrient criteria can be used for management planning and to establish standards and set limits for National Pollution Discharge Elimination System (NPDES) permits and for Total Maximum Daily Load (TMDL) targets (U.S. Environmental Protection Agency 1991).


A massive re-development program has been undertaken in Mumbai High, a multilayered complex carbonate reservoir, to increase oil production from the field. Drilling of horizontal and ERD (Extended Reach Drilling) wells is a major feature of this redevelopment program. The target layer for drilling the laterals is decided on the basis of log response and production behavior of the layers in the offset wells. In some cases, this becomes difficult because of ambiguous conventional log response in high angle/horizontal wells. The geometry of the laterals is decided after making a critical analysis of the geological model and also studying the structural configuration.


Luxury pawn startup borro and e-signature company DocuSign announced $112 million and $85 million rounds. Here's a look at some of the companies that raised money this week.


A novel approach using perturbation theory for simulating the noise behavior in free-running microwave oscillators based on a piecewise harmonic balance technique is outlined and applied to a planar integrated microwave oscillator at 14 GHz. A single-sideband phase noise of -90 dBc/Hz at an offset frequency of 100 kHz was measured. Simulated and measured single-sideband phase noise values agree within the accuracy of measurements. The method is limited neither to certain circuit topologies nor to certain noise sources. The proposed method has been demonstrated to be a fast, reliable, and numerically stable tool for the design of microwave oscillators.<<ETX>>


PLC was widely used in industrial automation,and it has a large geographical distribution.So it develops a remote wireless monitoring system based on TC35I,whose center unit is SCM.The system is successfully solved the data exchange between SCM and the PLC based on Hostlink protocol and the communication problems between SCM and TC35I module.So the remote wireless monitoring carried on the PLC system is realized.The system has easy to carry,practical,simple,large network coverage,low tariffs and other advantages.So it is practical and worthy of using abroad.


A new strategy to form ordered hierarchical supramolecular gels that incorporate graphene oxide (GO) sheets and cationic rigid macrocyles under mild conditions via self-assembly is demonstrated. These ordered gels are stabilized by a series of non-covalent - donor-acceptor, π-π stacking, cation-π - interactions. These theoretical studies indicate that cationic macrocycles are positioned in between GO layers with a substantial binding energy.


Marketing through Social Media and its Impact on Development of Business
Social Media is a method of interaction among people in which they create and share information. It is a group of internet based applications that build interactive platforms through which individuals and communities share, discuss and modify the user generated content.
Social media differentiates from traditional media in many aspects such as quality, reach, frequency, usability, immediacy and performance. Internet users continue to spend more time with social media sites than any other type of site. It also allow individuals to advertise themselves and from friendship.
A common thread running through most of the definitions of social media is blending of technology and social interaction for the co-creation value.


Black henna contact eczema is common and continues to increase. Paraphenyldiamine (PPD) in addition to its systemic toxicity not only exposes to a selective allergy to (PPD) but also to several of these derivatives and metabolites with cross reactions. We present a case of this irreflected practice. IMAGE ARTICLE


Since Bosnia and Herzegovina, on its path towards the European Union, during the recession and in the conditions of business environment complicated by complex governance structure, is confronted with numerous different challenges associated with investing in human capital, especially in a system of lifelong learning, we conducted the empirical research among 250 enterprises in Banja Luka to find out how local managers rate the importance of human resource development and whether the quantity and quality of training programs are positively related to the performance of their organizations. Although it is difficult to indicate the causal link between human resource development and the performance of an organization, the objective of this paper, in the context of systematized challenges of doing modern business, is to determine the importance of a strategic approach to development and the need to link employee development with business strategy. Keywords: contemporary challenges, knowledge-based economy, lifelong learning, learning organizations, human resource development


Protein tyrosine kinases have been in the focus of cancer research for many years. The hepatocyte growth factor receptor tyrosine kinase, commonly called Met/c-Met, is associated with cell proliferation, cell survival, motility, invasion and morphogenesis. In tumor cells, c-Met signaling is strongly deregulated, due to mutations, over expression or amplification of the receptor. Activated c-Met promotes tumor cell growth, migration and invasion, tumor angiogenesis and survival. 3] Targeting the c-Met kinase domain with selective inhibitors has emerged as a promising way to correct for this over activated c-Met signaling and thereby to treat distinct human tumors. In order to identify additional hit/lead structures for the development of novel ATP-competitive c-Met inhibitors we conducted a structurebased virtual screening campaign. A set of about 3.3 million purchasable screening compound structures from different vendors was retrieved from the ZINC Database. Elimination of duplicates reduced the initial dataset to about 2.8 million compounds with different stereochemistry and different protonation states. For these structures several properties and descriptors were calculated with FlexX and this data was afterwards used for a first filtering process. Since we were interested to find new chemical structures that might be used as kinase inhibitors, no pharmacophores but only ADME filters were used to reduce the number of compounds in this first step. Several filter combinations were tested on the set of 2.8 million compounds. A classical "rule of five" filter (mass< 500, logP<5, #HDon<10, #HAcc<5) reduced the number to 1.7 million compounds. To further narrow down and to shift the selection towards more lead-like compounds we reduced the molecular mass, the lipophilicity parameter, and the number of rotatable bonds resulting in a final filtering criteria set of mass<400, logP<4, number of HDon<10, number of HAcc<5 and number of rotatable bonds<8. Application of this filter resulted in 1.030.628 compounds. This combination furnished a set of about 1 million compounds, a number that could be managed by our docking setup. At the time of our project start only two X-ray crystal structures of c-Met were publicly available (1R0P and 1R1W). The structure of 1R1W is of an apo-enzyme with a nearly completely collapsed ATP-binding site. It was considered unsuitable for a virtual screening based on docking. The structure of 1R0P contains a staurosporine analog (K252a) in the ATP-binding site and is solved to a resolution of 1.8 . The activation loop in this structure adopts an inactive conformation that prevents ATP and substrate binding. This unique feature might be of benefit in the search for selective inhibitors. After the docking experiment and compound selection was completed, several other X-ray structures of c-Met have been published. The activation loop in these complexes had a different conformation or could not be observed in the experiments and the respective structures were not considered in this study. An active site was defined using FlexX, which included all protein atoms located closer than 6.5 to any atom of the ligand (K-252a). Water molecules were not included. Figure 1 depicts the binding site definition, complete with the original ligand K-252a. Atoms relating to the pharmacophore are displayed as balls (see Figure 1). To calculate relative distances in the active site, the coordinates of the lactamic nitrogen of the K-252a ligand were used as a probe atom. The first docking run used no pharmacophore constrains. FlexX succeeded in docking all compounds of the set to the previously defined binding site. This was a surprise be-


According to the structural characteristics and technical requirements of cold- forming profiles,the reasonable pressing technology scheme was worked out. The effect of different pressing technology on sheet- flow behavior was analyzed. The structure,work process and design of push and extrusion compound stamping die were introduced. Its compact structure,high efficiency and safe operation enable cold-forming profiles to locate accurately,form quickly and calibrate precisely.


Cloud computing provides elastic computational resources that have been widely deployed in data centres to provide Infrastructure as a Service (IaaS). Virtualization is a key technology in cloud computing for resource sharing. In the virtualization technology the most challenging issue is Virtual Machine Placement Problem (VMPP). Virtual Machine Placement is a significant process executed as a branch of VM migration, which involves placing a Virtual Machine (VM) on a suitable physical machine (PM) in order to improve the resource utilization efficiently. Many existing VMP algorithms considered the overall CPU capacity of a PM, without considering the number of cores available in a PM and core-CPU capacity of a PM. i.e. VMs are mapped onto PMs, if the CPU capacity of the VM is less than or equal to the total CPU capacity of a PM. Such an allocation results in core overload which leads to performance degradation and violation of Service Level Agreement. However, in the real scenario, PM and VM consists of multiple cores. So, to place VM on PM, the coreCPU capacity of a VM must be mapped to a core-CPU capacity of a PM. i.e., the core of a VM should be mapped to a core of a PM. In this paper, we have proposed a Multi-Core Aware Virtual Machine Placement Algorithm (MCA-VMP). In MCA-VMP, the number of cores available in a PM and core-CPU capacity of a PM is considered instead of total CPU capacity of a PM. We used, Google Cluster Traces to generate the virtual machine configurations. Based on Google Cluster Traces the dataset is generated. Monte Carlo Simulation method is used to produce Google Cloud Jobs (GoCJ). Our simulation results shows that MCA-VMP is efficient than traditional non-Core Aware VMP algorithms. Our proposed algorithm MCA-VMP improves the performance of a DataCenter in terms of resource utilization, PM overload and resource wastage.


Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.


Themain concept that guides through this commentary is exhaustivity associated with focus. Although this issue is not central to the authors' analysis, I believe that it leads to intriguing and puzzling questions that are worth considering. In their discussion in 4.3, Kamali and Krifka (henceforth, K & K) analyze focus exhaustivity by using the notion of 'denegation', the speech act version of negation. Informally speaking, the denegation of a speech act a is the refraining from engaging a. What is not clear to me is whether denegation is strong enough to guarantee the exhaustivity effect of focus. To illustrate this point, let us compare the two focalization strategies: focus and contrastive topic.


Information contained in the heart rate may be used to optimize the performance of cardiomyoplasties and therefore improve the quality of life of the patient.


A time-dependent Landau theory is proposed for the smectic-$A$-nematic phase transition. It is shown that the nematic viscosity coefficients exhibit a pretransition effect similar to that for the elastic constants.


Significance In mammals, embryo development can halt at the hatched blastocyst stage. Uniquely, proliferation of diapausing embryonic roe deer cells decelerates to a doubling time of 2 to 3 wk over a period of 4 mo. We highlight nutrient sensing as an important factor regulating embryonic developmental pace. The resumption of embryo development is characterized by an increase in uterine fluid mTORC1-activating amino acids, embryonic mTORC1 activity, and expression of metabolism and cell cycle genes. We propose selective mTORC1 inhibition via reduced estrogen signaling and high let-7 levels as mechanisms for slow cell cycle progression. We hypothesize that it is the lack of embryonic mTORC2 inhibition during embryonic diapause in the roe deer that enables the continuous decelerated rate of proliferation. Embryonic diapause in mammals leads to a reversible developmental arrest. While completely halted in many species, European roe deer (Capreolus capreolus) embryos display a continuous deceleration of proliferation. During a 4-mo period, the cell doubling time is 2 to 3 wk. During this period, the preimplantation blastocyst reaches a diameter of 4 mm, after which it resumes a fast developmental pace to subsequently implant. The mechanisms regulating this notable deceleration and reacceleration upon developmental resumption are unclear. We propose that amino acids of maternal origin drive the embryonic developmental pace. A pronounced change in the abundance of uterine fluid mTORC1-activating amino acids coincided with an increase in embryonic mTORC1 activity prior to the resumption of development. Concurrently, genes related to the glycolytic and phosphate pentose pathway, the TCA cycle, and one carbon metabolism were up-regulated. Furthermore, the uterine luminal epithelial transcriptome indicated increased estradiol-17β signaling, which likely regulates the endometrial secretions adapting to the embryonic needs. While mTORC1 was predicted to be inactive during diapause, the residual embryonic mTORC2 activity may indicate its involvement in maintaining the low yet continuous proliferation rate during diapause. Collectively, we emphasize the role of nutrient signaling in preimplantation embryo development. We propose selective mTORC1 inhibition via uterine catecholestrogens and let-7 as a mechanism regulating slow stem cell cycle progression.


This article describes an empirical study of the rise and fall of star athletes, using data from the National Basketball Association (NBA) from 1987 to 2008. We measure star status by the number and share of all-star votes, and we apply both Tobit regression and hazard models to investigate the determining factors for star status. We find that the attainment of star status begins with the athlete's exceptional individual performance. We also find that having won a championship in the past can have a long-lasting effect on a player's popularity. The popularity of an athlete depends on his team in two ways: the attainment of star status is associated with strong team performance, and star teammates can reinforce each other's popularity. Interestingly, whereas stars can move from a losing team to a winning team to extend their star life, a team change can be very risky for new stars. Our results also suggest that teams with a large fan base, winning records, and star players should leverage these assets in attracting and retaining star players.


The objectives of this slide presentation are to review the activities on the lunar surface during the stay. The objectives include (1) Summarize Lunar Module Basics emphasizing module layout and storage. (2) Identify the primary activities occurring during each of the lunar s urface timelines, (3) List the EVA Prep tasks, (4) Identify the EVA Objectives, (5) Identify the activities associated with Post EVA (6) Describe the lessons learned during both EVA and Non EVA activities. Included are overview drawings of the Lunar Roving Vehicle, pictures of the tools, and sample return containers. There are also time lines for the Apollo 11, and Apollo 12 through 14, Apollo 15, Apollo 16 and Apollo 17. Diagrams of the EVA suits are shown, including the Liquid Cooling Garment, and the Pressure Garment Assembly. The activity prior to the EVA are reviewed. The science mission assignments of each mission are viewed. The activities after the EVA are reviewed


Background: Background: Assessment of patient-reported outcomes (PRO) can inform how real-life standard of care (SOC) treatments affect health-related quality of life (HRQoL) for patients with relapsed/refractory multiple myeloma (RRMM). We present measures of symptoms, functioning, and overall HRQoL from LocoMMotion (NCT04035226), the first prospective, multinational study of real-life SOC in triple-class exposed patients with RRMM. Aims: Aims: To assess HRQoL in patients with RRMM receiving real-life current SOC in the LocoMMotion study. Methods: Methods: All patients provided informed consent. LocoMMotion is a noninterventional study across 76 sites (63 Europe, 13 United States) in patients who had received ≥3 prior lines of therapy (LOT) or were refractory to proteasome inhibitor (PI) and immunomodulatory drug (IMiD). Patients received PI, IMiD, and anti-CD38 monoclonal antibody and had disease progression during/after their last LOT. Real-life SOC treatments were defined as those used in local clinical practice. The following questionnaires were used: European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30), 4 single items from EORTC QLQ-myeloma-specific module (EORTC QLQ-MY20), and EuroQol 5-Dimension 5-Level (EQ 5D-5L). HRQoL data were collected at baseline (BL), day 1 of each treatment cycle, end of treatment visit, and during follow-up (every 4 weeks). Established thresholds were used to evaluate improvement compared with BL health status. Mixed models for repeated measures were used to assess within-group change. Results: Results: The questionnaire completion rate was 75.6% during SOC treatment in the LocoMMotion study (N=248; male: 54.4%; median age: 68 years; median cycles of SOC: 4.0 [range: 1-20]). Most Summary/Conclusion: Summary/Conclusion: This first prospective study of real-life current SOC in triple-class exposed patients with RRMM reported limited gains in HRQoL, most notably in pain symptoms. There is an urgent and unmet need for therapies that lead to deep responses and delayed disease progression, as these are associated with improvements in HRQoL.


A numerical investigation of the eigenvalue problems related to both the energy and the linear theory of stability of a Newtonian liquid between sliding pipes is presented. An enlargement of the region of nonlinear stability is shown as the radii ratio is increased. On the other hand, the flow always turns out to be linearly stable.


There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test and passive avoidance (step through) test were investigated. Rats were microinjected unilaterally through implanted guide cannulas into the CA1 area of the dorsal hippocampus and the drugs were administered separately, 5 minutes before each training session. The microinjections of losartan into the left, but not the right CA1 hippocampal area improved the acquisition and retention of active and passive avoidance learning, thus suggesting dependence on the side of injection. The unilateral (left or right) administration of angiotensin II did not significantly affect the performance of OBX rats in the avoidance tasks. A differential distribution of the AT1 receptors in the left and right hemisphere could contribute for the asymmetry in the behavioral effects of the AT receptor antagonist.


Background information. Immature dental papilla stem cells and mature dental pulp stem cells are capable of performing the dentinogenesis under suitable circumstances. However, a dentinogenic comparison between immature and mature dental root stem cells remains unknown.


Report presenting free-flight and free-jet testing of a twin side-inlet configuration, including a pilot's canopy and a wheel-well fairing, between a range of Mach numbers from 0.8 to 1.55. Using side inlets provides two important advantages: the inlet can be located closer to the engine and it frees up the nose for other uses. Results regarding the effects of oscillating flow, external-drag coefficient, and total-pressure recovery are provided.


This paper presents a proposal for collective systems for handling manure, also called clusters, and consequent generation of electricity from biogas, for a swine herd installed in 2012 in the municipalities of Serafina Correa and Uniao da Serra, in the State of Rio Grande do Sul, Brazil. From the preparation of sand, hypsometry and slope maps for both municipalities associated with plotting the location of the swine herds, this work proposed five clusters where the waste of 8,660 animals are conducted entirely by gravity. The biogas generated in the anaerobic treatment is transformed into electrical energy could supply 285 homes whose average monthly consumption is 200 kWh or can be inserted into the internal or external network of property, corroborating in extra income to swine farmers and the sustainability of the activity. From this objective, the job initiates a technical assessment in order to enable these collective treatment systems and reduce the environmental impacts generated by swine activity.


The economic approach to health promotion describes human behaviour towards preservation of individual health by methods of the economic analysis. We have developed mathematical model based on the Grossman's theory of Demand for Health (1972) showing two basic approaches. The investors prevent diseases by adopting healthy lifestyle and therefore minimize costs of healthcare. The consumers, however, depend on the healthcare system and cause further increase of its expenditures. It is also demonstrated that the latter approach leads to the increase of expenditures on maintaining the level of public health. Also the strong incidence of chronic and almost incurable non-communicable diseases excludes passive consumerism care for their own health from the rational choice. These effects vary in developing and developed countries and further burden healthcare systems for instance in the new EU Member States.


Developing plan is the scheme,prospect,arrangement and disposition for the future development of civilian-run colleges and universities as well as the exhibition of the developing aim,idea and mode of the schools in certain historic period.While setting up the plan,the colleges and universities should harmonize the relation between the school's development and the external conditions,make their running practice meet the need of society,thus realize their sustainable development.For this goal,the civilian-run colleges and universities should take the scientific developing conception as the guidance,on the foundation of scientific orientation take the connotative developing way,continuously strengthen their core competitive force,enhance their education quality,project their school-running feature and through setting up the concerned special mode cultivate the high quality people of ability who have practical power thus realize their prestigious effect.


A field investigation was carried out at Floriculture Unit, Department of Horticulture, Dr. PDKV, Akola during the years, 2016-17 and 2017-18 in Randomized Block Design to study the "Performance of marigold rooted cuttings on yield and quality transplanted from different growing media". The treatments comprised of twelve different propagating medias viz. soil, sand, vermicompost, FYM, cocopeat, soil + sand (1:1), soil+ vermicompost (1:1), soil + FYM (1:1), sand + vermicompost (1:1), sand + FYM (1:1), soil + sand + vermicompost (1:1:1) and soil + sand + FYM (1:1:1) with three replications. The results of the experiment revealed that, performance of transplanted marigold plants in respect of yield parameters viz. weight of flowers plant-1, number of flowers plant-1,flower yield plant-1, plot-1and ha-1 were noticed maximum in the plants obtained from the vermicompost media. In respect of quality parameters, essential oil content and yield of xanthophyll obtained from different growing medias were found statistically non significant during both the years of the experimentation.


The new Unbound Pavement Specification will contain four types of unbound pavement material. Two of these types are principally for use in dry environments. These are Type 3 (dry environment, medium to low loading) and Type 4 (dry environment, medium to low loading, "non standard" materials). This paper describes the philosophy behind the drafting of the specification, discusses why the particular standards were included and gives guidance in the use of the types. There is also some discussion about the limitations of a standard specification to accommodate all materials and also to completely guarantee the performance of a specified material. Alternative limits and standards are suggested for use in specific cases which a standard specification cannot adequately accommodate (A).


A DISSERTATION SUBMITTED TO THE SCHOOL OF POST GRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF A MASTER OF SCIENCE (M.Sc) DEGREE IN TELECOMMUNICATION ENGINEERING DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING FACULTY OF ENGINEERING AHMADU BELLO UNIVERSITY, ZARIA
NIGERIA


The article raises questions of archetypical determination of journalistic work and examines the phenomenon of an archetype in the context of its influence on the content of media text.


Through the analysis of the labor resources and the state of employment and unployment of Quanzhou,the article explores the main problems existing in the labor resource allocation in towns and suggests to improve the labor market,set up the employment service system,accelerate the development of tertiary industry,improve the quality of workers and vocational skills,so as to ease the pressure and contradiction of employment and protect the healthy development of the socio-economic harmony.


Abstract We describe a 43-year-old man who developed a spontaneous dissection of a right iliac artery aneurysm after performing vigorous physical exercise. Additionally, during peripheral intervention, the patient developed iatrogenic dissection of the left iliac artery. The patient had the characteristic physical findings of Ehlers–Danlos syndrome (EDS), classic type. Genetic testing revealed a mutation in the COL5A1 gene associated with EDS, classic type. Vascular aneurysms and dissections are characteristics of EDS vascular type, but not the classic type. Only one previous case with EDS, classic type with spontaneous iliac artery dissection has been described.


Forgotten Password? The cognitive dimensions of reading are well researched and have resulted in a palette of Elementary Reading Attitude Survey (McKenna & Kear, 1990)Survey of Adolescent These experiences include the impact of instruction, which contributes to a student's growing awareness of proficiency. Girls' attitudes, measured at both the implicit and explicit level, remain stable. been described as experiencing relatively limited direct instruction (Study 1).


DNase is an enzyme belonging to the endonuclease group. It is the most examined enzyme among endonucleases that degrades double-stranded DNA. In addition, DNase is used as a tool in molecular biology and for treating cystic fibrosis.
Cytotoxins CdtABC are a group of protein toxins that are present in bacteria from the Proteobacteria family. Owing to their DNase activity, they are genotoxic to eukaryotic cells.
The thesis compares the activity of an enzyme from the endonuclease group, i.e. bovine pancreatic endonuclease DNase I with the CdtB subunit from the bacteria Aggregatibacter actinomycetemcommitans. We focused on the comparison of two enzymatic methods and the conditions necessary for the activity of DNase I and subunit B from the CdtABC cytotoxin.


We calculated neutron induced Single Event Upset (SEU) cross-section as well as the Soft Error Rate (SER) at ground level. For this purpose, we first used an accurate model based on simulation of atmospheric neutron-induced transient currents in a 90-nm drain electrode, through a detailed diffusion model. Then, we performed the same simulations by replacing each transient current by a simple double exponential law model, for which the parameters were set in order to keep the same total charge as for the diffusion model, as well as the same value of maximum current and its corresponding occurrence time. Our results show a little increase of the cross section while using the double exponential law and we established a correlation between the parameters characterizing the double exponential and the diffusion model curves.


In work the theoretical bases and dynamics of processes of modernization of the Russian higher education are studied, conditions and specifics of its last cycle reveal (the end of XX – the beginning of the 21st centuries). The attention to global character, interaction with the international educational space is paid. The professional community of teachers (scientific and pedagogical workers) of the higher education (HE) acts as an object. Research objective – identification of a state, opportunities and conditions of realization of resource potential of teachers of higher education institutions for ensuring modernization of higher education. Studying of problems of resource ensuring modernization was carried out from positions of system, constructivist, resource, activity and structurally functional approaches. The empirical base was made by materials of the all-Russian sociological researches: questionnaire, expert interviews. The new scientific idea that the speed of modernization changes of system of the higher education depends on a state and conditions of updating of resource potential of community of teachers of higher education institutions is developed; their resource potential develops unevenly and depends on inclusiveness degree in an educational vertical and the status of higher education institution. Concepts of resources and resource potential of modernization of education are entered, their substantial characteristics are opened. Recommendations about optimization of this process are submitted.


It is unacceptable that budgetary provision has not been made with respect to these decisions, particularly since implementation of the provisions relating to internal ivory markets is a condition for the resumption of trade. Desk research will not give the level of reassurance that many Parties would require. The onus should be on those Parties, CITES bodies and nongovernmental organizations (NGOs) advocating the resumption of ivory trade to find the funds necessary to ensure that the decisions made at COP12 are fully implemented.


The article presents the results of a study of the theoretical and methodological foundations for the implementation of projects for the interaction of the production sector of the penal system with representatives of the business community. Analyzed and summarized the specific features of public-private partnership in the production sector of the penitentiary system.


This paper describes the development of tomographic techniques suited to the reconstruction of data obtained from holographic interferograms, and some initial results. The principle development discussed is the treatment of the data in three dimensions rather than the conventional approach of simplifying the problem to the reconstruction of a series of layered 2D slices. A discussion of different tomographic algorithms is also included.


Global positioning systems (GPS) are likely to revolutionize animal telemetry studies. GPS collars allow biologists to collect systematically scheduled data when VHF telemetry data is difficult or impossible to collect. Past studies have shown that the success of GPS telemetry is greater when animals are standing, or in open habitats. To make effective use of GPS telemetry, biologists need to understand its advantages and disadvantages. Our objectives are to compare data from GPS and VHF telemetry, present data on the use of activity sensors for estimating behavior and show that unsuccessful GPS fix attempts can provide insights into the biology of elk. We placed two GPS telemetry collars, capable of remote transmission of data to a command unit, and 44 VHF telemetry collars on adult female (cow) elk (Cervus elaphus).The GPS collars were programmed to take three fixes, three days each week. These GPS collars did not operate properly. In February 2000, we placed four store-on-board GPS collars from a different manufacturer on cow elk. These collars were programmed to collect 6 - 12 locations each day, with drop-off mechanisms set for December 1, 2000. The average success in acquiring fixes was 88%, with 70 % 3D locations. Each GPS collar collected more locations of elk than were obtained by three technicians working >2 yr using VHF telemetry. Tiltswitch activity sensors suggested that elk were feeding in 40% of locations. The data indicated that feeding and bedding occurred in all habitats. As expected, elk appeared to spend more time feeding than bedded in grasslands during both daytime and night-time hours. Disparity between the number of feeding and bedding locations in grasslands was less during night-time. Unsuccessful GPS fix attempts occurred more often when elk were bedded (P < 0.0 1) and more often during daytime than night-time or the crepuscular periods (P


The results of pharmacotherapy can vary both within and between different populations and ethnic groups. Although numerous factors are believed responsible for observed discrepancies in drug response, genetic differences, most often in the form of single nucleotide polymorphisms (SNPs), between individuals and ethnic groups are an important and at times predominant factor. The response to antiretroviral (ARV) drugs for the treatment of human immunodeficiency virus (HIV)-infection is not dissimilar. Marked variations in both ARV efficacy and occurrence of adverse drug reactions (ADRs) have been observed on both an individual and ethnic group level, which are largely attributed to polymorphisms within genes involved in the metabolism and transport of these compounds – such genes include the CYP2B6 and CYP3A4 genes, both members of the cytochrome P450 (CYP) gene superfamily, and the multidrug-resistance 1 (MDR1) gene encoding an efflux transporter protein, phosphoglycoprotein (PGP). An improved understanding of the genetic influences on ARV drug response could lead to improved therapies with fewer side-effects and minimised drug resistance. The main aim of this study was thus to investigate the genetic basis of observed differences in ARV therapy (ART) response in South African ethnic groups. Deoxyribonucleic acid (DNA) samples were collected from 206 HIV-positive individuals of Mixed-Ancestry and Xhosa ethnicity that were currently or prospectively receiving ART. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was employed to screen the A-392G SNP in CYP3A4, the G516T and A785G SNPs in CYP2B6, and the T-129C, C1236T, G2677T/A and C3435T SNPs in MDR1. Hardy-Weinberg equilibrium (HWE) and haplotype analyses were subsequently performed on the resultant SNP genotype and allele frequencies. The possible effects of ethnicity on ART response were examined by means of univariate two-way analysis of variables (ANOVA) testing. Univariate one-way ANOVA testing of the change in cluster of differentiation 4 (CD4)-cell count after six months of ART was used to analyse the possible effects of the seven polymorphisms on immune recovery. All seven SNPs were found to be in HWE in both the Mixed-Ancestry and Xhosa ethnic groups. An extremely high level of linkage disequilibrium (LD) between the 516 and 785 loci in CYP2B6 was detected in both the Mixed-Ancestry (r = 0.97; logarithm of the odds (LOD) score = 24.84) and Xhosa (r = 0.98; LOD score = 41.31) ethnic groups. LD was also detected between the 1236, 2677 and 3435 loci in MDR1 in the Mixed-Ancestry population, although none was found between any of the examined MDR1 SNPs in the Xhosa population. Univariate two-way ANOVA testing found no apparent effect of ethnicity on immune recovery in response to ART. Univariate one-way ANOVA testing detected a discernible effect of genotype on immune recovery in the cases of the T-129C (p = 0.03) and G2677A (p < 0.01) polymorphisms in the MDR1 gene. Therefore, this study identified no effect of ethnicity on ART response but did detect an association between the T-129C and G2677A SNPs in MDR1 and the level of immune response to ART. These findings suggest that MDR1 polymorphisms can be predictive of immune recovery after initiation of ART. This study thus represents an important step towards improved ART drug regimens in South African populations.


In the profession of architects there is an element called architectural competitions,
where several architects compete in submitting the best solution for a certain task. In
this master's thesis I am studying the competitor's perspective of an international
architectural competition, while at the same time gaining experiences for my future
career as a landscape architect. The aim of this thesis is to through an introspection of
my own process examine a competitors view of the international architectural
competition and how to approach the difficulties concerning international competitions.
Through that I hope obtain experience about the international competition as part of
the profession of landscape architects and other involved professions. To examine a
competitor's reflection of an international competition, I entered and competed in
LE:NOTRE Student Competition, a competition for students where the task was to
develop 25 kilometers of complex urban periphery along a chain of natural and artificial
lakes in Bucharest, Romania. My working process contained a five step method of
Research - Conceptual ideas - Inventory - Analysis - Proposal where I went from knowing
nothing at all about the site and the task, to completing a proposal and submitting it in
the competition. The idea of my competition submission called Retain, Restore and
Revive, build upon the intentional purpose of the artificial lakes; to serve as water
supply, irrigation, fishing and primary leisure. Existing values will be retained, vacant
lands and available shores will be restored into green spaces and the entire area will be
revived with a new identity uniting people and attracting tourists. Discussing the
working process and the results, I bring up the difficulties in competing in an
international architectural competition and what experiences I obtained through my
introspection of my participation in a competition. I also discuss creating a competition
submission that is both innovative and unique and at the same time fulfills the aim and
requirements. Furthermore, I discuss the wider perspective of international architectural
competitions, if they contribute in creating high quality architecture or not and if they
may contribute in a global generalization of architecture and less cultural differences in
the long term. Lastly, I mention my own experience and development when completing
this competition and the master's thesis, how I have found myself as a landscape
architect and the harmony in designing.


Piezoelectric vibration generator made in MEMS can infinite and continue to supply energy for wireless sensor network. For increasing generating capacity of cantilever piezoelectric vibration generator with limited volume,influence rule of structure parameter to generating capacity of unimorph,bimorph in series type and bimorph in parallel type piezoelectric vibration generator are analyzed by finite element modeling and experiment. The results indicate that output circuit voltage of bimorph in series type beam with smaller thickness ratio is larger; one optimal load exists to make output power maximum; output power of bimorph in series type beam is basically same with bimorph in series type beam's,which is higher than unimorph's at the same material and structural parameter.


With the increase in the military and several other applications of Wireless Sensor Network, provisions must be made for secure transmission of sensitive information
throughout the network. Most of the routing protocols proposed for ad-hoc networks and sensor networks are not designed with security as a goal. Hence, many routing
protocols are vulnerable to an attack by an adversary who can disrupt the network or harness valuable information from the network. Routing Protocols for wireless sensor networks are classified into three types depending on their network structure as Flat routing protocols, Hierarchical routing protocol and Geographic routing protocols. Large number of nodes in a wireless sensor network , limited battery power and their data centric nature make routing in wireless sensor network a challenging problem. We mainly concentrate on location-based or geographic routing protocol like Greedy Perimeter Stateless Routing Protocol. Sybil attack and Selective forwarding attack are the two attacks feasible in GPSR. These attacks are implemented in GPSR and their losses caused to the network are analysed.


This master thesis hopes to be a first approach in the study of the moisture control of the district heating networks. Nowadays the moisture control is based on the resistance value analysis and the time-domain reflectometer usage. These two technic has been proved to be an effective combination in order to detect and localize leakages in the networks. Despite this fact, there is not a wide knowledge about the actual behaviour of this system and the influence of different factors to the system, such as the differentiation between internal and external leakage, the control of the time influence in the system or the external condition influence in control. In order to increase the knowledge of theses two systems and their relation with the system variables, different tests were developed. These tests can be divided into two main groups; the first ones were related with the moisture alarm behaviour in different moisture conditions (related with time, volume and dimensions) while the second group was related with the pipe isolation water absorption for different salt concentrations. The combination of these tests have made the perception of the importance of the time control in the moisture alarm possible due to the facts that the moisture is transferred through the isolation with low speed ratios and that the moisture alarm has showed some limitations. At the same time the study of the alarm reaction to different moisture states has shown a relation between the moisture conditions and alarm results. These results make the idea of a future better knowledge of the network real state based on the time control, the variables study and the moisture alarm reaction possible. But in order to be able to reach this knowledge, some other studies and tests related with the moisture alarm are needed. Table
  of
  Contents 1
   Introduction
  ........................................................................................................
  1 1.1
   The
  district
  heating
  as
  a
  high
  performance
  heat
  generation system
  .......................................................................................................................
  1 1.2
   District
  heating:
  generation
  and
  distribution
  ..................................
  3 1.3
   The
  heat
  distribution
  ................................................................................
  4 1.4
   The
  leakage
  control
  in
  the
  network:
  the
  moisture
  alarm
  ............
  5 2
   Objective
  and
  limitations
  ................................................................................
  7 3
   Theoretical
  Foundation
  ...................................................................................
  9 3.1
   The
  district
  heating
  network
  .................................................................
  9 3.2
   The
  moisture
  alarm
  installation
  ........................................................
  10 3.3
   Physic
  properties
  related
  with
  the
  moisture
  control
  .................
  12 3.3.1
   The
  loop
  resistance
  .......................................................................................
  12 3.3.2
   The
  isolated-‐wire
  resistance
  .....................................................................
  14 3.3.3
   Polyurethane
  electric
  resistivity
  .............................................................
  14 3.3.4
   Moisture
  absorption
  behavior
  for
  a
  polyurethane
  foam
  ..............
  15 3.4
   Moisture
  control
  bases
  ..........................................................................
  15 3.4.1
   Resistance
  meter
  principle
  ........................................................................
  16 3.4.2
   Principle
  of
  the
  time
  domain
  deflector
  (TDR)
  as
  .............................
  17 3.5
   Material
  data
  .............................................................................................
  18 3.5.1
   Materials
  conductivities
  ..............................................................................
  18 3.5.2
   Dielectric
  constant
  .........................................................................................
  20 4
   Method
  ...............................................................................................................
  22 4.1
   Methodologies
  ..........................................................................................
  22 4.2
   Experimental
  apparatus
  and
  designed
  tests
  for
  the
  moisture detection
  with
  TDR
  and
  resistance
  control
  ..............................................
  22 4.2.1
   Methodology
  1:
  waterline
  connected
  to
  a
  water
  tank
  ...................
  23 4.2.2
   Methodology
  2:
  waterline
  pressurized
  ................................................
  24 4.2.3
   Methodology
  3:
  controlled
  water
  injection
  in
  the
  foam
  ................
  24 4.2.4
   Measuring
  equipment
  ..................................................................................
  26 4.3
   Moisture
  absorption
  for
  the
  PUR
  foam
  ............................................
  27 5
   Results
  ................................................................................................................
  28 5.1
   Moisture
  detection
  with
  TDR
  and
  resistance
  control
  .................
  28 5.1.1
   Results
  for
  the
  methodology
  1:
  Waterline
  connected
  to
  a
  water tank
   28 5.1.2
   Results
  for
  the
  methodology
  2:
  Water
  line
  pressurized.
  ..............
  28 5.1.3
   Results
  for
  the
  methodology
  3:
  ................................................................
  29 5.2
   Moisture
  absorption
  for
  the
  PUR
  foam
  ............................................
  39 6
   Discussion
  .........................................................................................................
  40 6.1
   Time
  influence
  in
  the
  moisture
  control
  ...........................................
  40 6.2
   Moisture
  alarm
  accuracy
  ......................................................................
  41 6.3
   Moisture
  alarm
  behaviour
  to
  different
  water
  states
  ..................
  41 7
   Conclusion
  .........................................................................................................
  46 References
  ...............................................................................................................
  48 List
  of
  Figures FIGURE
  1:
  DISTRICT
  HEATING
  PENETRATION
  BY
  COUNTRIES

  [1]
  .........................................................................
  2 FIGURE
  2:
  DISTRICT
  HEAT
  PRODUCTION
  IN
  THE
  NORDIC
  COUNTRIES
  [2]
  ............................................................
  3 FIGURE
  3:
  HEAT
  LOSSES
  IN
  A
  DISTRICT-‐HEATING
  NETWORK
  [3]
  ..........................................................................
  5 FIGURE
  5:
  CONNECTION
  PRINCIPLE
  IN
  A
  TWO-‐WIRES
  SYSTEM
  [11]
  ..................................................................
  11 FIGURE
  6:
  OPEN
  SYSTEM,
  THE
  WIRES
  IN
  THE
  SUPPLY
  AND
  THE
  RETURN
  LINES
  ARE
  CONNECTED
  IN
  ONE
  LOOP [11]
  ....................................................................................................................................................................
  12 FIGURE
  7:
  EQUIVALENT
  ELECTRICAL
  DIAGRAM
  FOR
  A
  DIELECTRIC
  MATERIAL
  (A)
  AND
  CORRESPONDING PHASE
  SHIFT
  DIAGRAM
  (B).
  ............................................................................................................................
  14 FIGURE
  8:MOISTURE
  GAIN
  FOR
  A
  PUR
  FOAM
  20MM
  THICK
  [12]
  ......................................................................
  15 FIGURE
  9:
  THE
  PRINCIPLE
  OF
  FAULT
  DEFECTION
  USING
  SENSOR
  WIRES
  ............................................................
  16 FIGURE
  10:ELECTRIC
  EQUIVALENT
  CIRCUIT
  FOR
  THE
  PRE-‐INSULATED
  PIPE
  ....................................................
  16 FIGURE
  11:
  TDR
  PRINCIPLE.
  ....................................................................................................................................
  18 FIGURE
  12:
  ELECTRICAL
  CONDUCTIVITY
  FOR
  PUR
  FOAM
  [7]
  ............................................................................
  19 FIGURE
  15:
  REPRESENTATION
  OF
  THE
  RELEVANT
  DIMENSIONS
  IN
  THE
  MOISTURE
  CONTROL
  (L,
  W,
  H)
  .....
  25 FIGURE
  18:
  TDR
  RADAR
  REACTION
  TO
  DIFFERENT
  MOISTURE
  STATES.
  FROM
  TOP
  TO
  DOWN:
  WITHOUT MOISTURE,
  WITH
  3.5ML
  AND
  16ML.
  .............................................................................................................
  31 FIGURE
  19:
  TDR
  RADAR
  REACTION
  TO
  DIFFERENT
  MOISTURE
  STATES.
  FROM
  TOP
  TO
  BOTTOM:
  1) STANDARD
  STATE
  (NO
  MOISTURE);
  2)
  WITH
  2,5ML
  OF
  WATER;
  3)
  WITH
  8
  ML
  OF
  WATER
  ...............
  33 FIGURE
  20:
  TDR
  RADAR
  REACTION
  TO
  DIFFERENT
  MOISTURE
  STATES.
  FROM
  TOP
  TO
  BOTTOM:
  4)
  WITH
  10 AND
  12
  ML
  OF
  WATER;
  5)
  WITH
  16ML
  OF
  WATER;
  6)
  SHORT-‐CIRCUIT
  STATE
  .....................................
  34 FIGURE
  21:
  :
  TDR
  RADAR
  REACTION
  TO
  DIFFERENT
  MOISTURE
  STATES.
  FROM


UPON arrival in the New World, the New England colonists made a fundamental choice: they rejected the English feudal pattern and instead based their society upon the independent farmer. Wielding axe, hammer, and scythe, the yeoman farmer subdued his acreage himself, while his wife plied the spindle, stirred the churn, and rocked the cradle. With neighbors who shared equal opportunity, he performed the citizen's duties of promoting learning and religion. Even through the close of the nineteenth century, when youth increasingly abandoned the farms for more lucrative urban occupations or land farther west, the self-sufficient rural family continued to be regarded as the cornerstone of a democratic society. Records left by generations of New England farmers during this period of western expansion show their appreciation for a unified society. Agricultural gatherings fostered a strong sense of community, and experiences were exchanged in magazines such as the Cultivator and Country Gentleman and the New England Farmer. In the proceedings of state boards were reported the creation of agricultural societies in the West, the changing character of those in the East, and interests common to both; the southern plantation slave-labor society was also examined. That society recognize the farmer's dignity was a concern commonly expressed at the agricultural meetings. "There is no pursuit that tends more directly to the independence and happiness of the people than agriculture," the governor of New Hampshire told the legislature in 1836. "It is a matter of gratification and pride that it is a calling scarcely less reputable than that requiring the highest order and severest application of intellect."' In a similar spirit, a speaker before the


In this paper the effect of temperature on translocation of 32P in rice plant was investigated 32P was applied to the leaf and the distribution pattern of the translocated 32P was determined by means of autoradiography. In case of examining the effect of temperature upon the whole plant body, the experiments were achieved by placing the plants in glass rooms which were adjusted to 17°, 21°, 25°, and 29°C respectively, and for the purpose of examining the effect of temperature on translocation when various temperatures were applied to the translocation passage, about 5cm of the upper part of the internode of the ear-neck, which is yet enveloped in the sheath of the flag leaf was chilled or warmed using an apparatus newly devised by the authors. As the results of the experiments, when the plant body was cooled at about 17°C, translocation of 32P was markedly affected. When the plant body was partially chilled at about 10°C, translocation was blocked almost completely. On the other hand, when the plant body was partially warmed at around 30°C, translocation was restrained too. So either excessively high or low temperatures are not favorable for translocation of nutrients.


Alpha Ketoglutaric Acid (AKG), one of two ketone derivatives of glutaric acid is an important biological compound that serves as a natural scavenger of ammonium ion, facilitating its conversion to amino acids and protein. AKG inhalation has potential therapeutic role against ammonia-induced structural and inflammatory changes in the lungs. In the present study sub-acute inhalation toxicity of a novel submicronic AKG respiratory formulation was evaluated in Sprague Dawley rats. Sub-acute inhalation toxicity study of novel AKG respiratory formulation at doses, 1, 3 and 5% was conducted as per Schedule-'Y' guidelines of ICMR, India. Hematological, serum biochemical and lung toxicity biomarkers in bronchoalveolar lavage (BAL) fluid were determined. Histopathological analysis of lung tissues and other vital organs was carried out to observe any microscopic changes. Hematology, serum biochemistry and lung toxicity biomarkers in BAL fluid revealed no adverse effects of AKG inhalation except for a slight increase in levels of BAL fluid protein. At autopsy, no histopathological changes in major vital organs, including the lungs were observed. The safety evaluation data suggest that aerosols of submicronic AKG respiratory formulation are safe for inhalation and could be developed as a potential therapeutic option against lung injuries induced through chemical toxicants such as ammonia.


Nanoindentation studies were performed on AISI 316L austenitic stainless steel after its electropolishing under varied conditions and keeping such obtained samples in the Ringer's solution for a year period of time. The Young's modulus of elasticity and hardness were investigated. The mechanical properties of AISI 316L stainless steel biomaterial demonstrated an evident dependence on the treated electropolishing conditions. After magnetoelectropolishing (MEP) treatment some improvement in mechanical properties of the same steel biomaterial is observed in comparison with the ones after a standard electropolishing (EP).


Background: The aim of the present paper was to investigate the molecular epidemiology of norovirus gastroenteritis in Japan using polymerase chain reaction (PCR) and subsequent phylogenetic analysis.


Mounting structure for the roof of the building is provided with a sacrificial material, by the sacrificial material, free movement between the sacrificial material itself and the roof, as well as the free movement between the sacrificial material itself and mounting structure It can become. .Field


Firstly,the development of pervasive computing is surveyed— — International scholars are focusing user interface,contexta-ware computing,smart space,and etc.And then a security reference model of pervasive computing architecture is put forward.The main research content of pervasive computing is discussed including: Security operation system layer,security computing layer,security collectivity layer.At last,the security reference model is simulated to carry on the experiment.


The convergence of the Moller–Plesset expansion is examined for Ne, F−, CH2, and HF and analyzed by means of a simple two-state model. For all systems, increasing diffuseness of the basis introduces highly excited diffuse back-door intruder states, resulting in an an alternating, ultimately divergent expansion. For F−, the divergence begins already at third order; for the remaining systems, it begins later. For CH2, the low-lying doubly excited state leads to a monotonic, slowly decreasing series at lower orders; for the stretched HF molecule, the low-lying doubly excited states lead to a slowly undulating series at lower orders. Although the divergence of the Moller–Plesset series does not invalidate the use of the second-order expansion, it questions the use of higher-order Moller–Plesset expansions in quantum-chemical studies.


This Letter presents an approach for applying atmospheric correction to remotely-sensed data in near-real time. In general, it is applicable to the visible and near-infrared part of the spectrum and in particular, it has been tested with channels 1 and 2 data from the Advanced Very High Resolution Radiometer (AVHRR). This algorithm makes an extensive use of look-up tables and it resulted in the speed of about 3 scanlines per second whereas the AVHRR data reception rate is 6 scanlines per second.


Glass-fibre reinforced concrete (GRC) noise barriers have been produced for more than 20 years. GRC does not compete with concrete on price alone, but its advantages include aesthetics and rapid and reduced installation costs. GRC requires minimal maintenance and cleaning should be unnecessary if the barriers are sealed or painted with anti-graffiti paint. By blocking the line of sight, a solid noise barrier with a mass of more than 20 kg/m2 gives a noise reduction of 5dB. Each additional 1m height above the line of sight gives about 1.5dB additional noise reduction. Despite its narrow section, a thin, flat GRC highway noise barrier can perform as well as a concrete, masonry or thick timber panel. GRC can be made with a profile to disperse the noise in a controlled manner or as an absorption panel with a permeable grill and insulating core. Concrete and GRC allow artistic freedom with colour, shape, pattern and texture. Case studies are presented of the use of GRC noise barriers: viaducts at Glebe Island and on the M4 motorway in Parramatta in New South Wales, Australia; mixed polycarbonate/GRC panels on the elevated motorway leading to Santa Cruz de Tenerife, Spain; the A86 bridge over the River Seine at Choisy le Roi, France; the A3 Autoroute in Paris, France; barrier use in Hong Kong; and the A44 autobahn in Duesseldorf, Germany.


This work deals with the simulation of water vapor ingress into wafer-based PV-modules for long-term exposure under different climatic conditions. Measured material parameters together with climatic data sets from four test sites (tropic, moderate, alpine, and arid) were used to calculate the water concentration inside of the encapsulant between solar cell and glass for a lifetime of 20 years. Two back-sheet materials (PET-based and PA-based) combined with EVA as encapsulant were used in respect to their influence on water ingress. The results show faster water ingress for warmer regions, but the highest concentrations were found for the moderate test site. The water ingress was additionally influenced by the used encapsulant and back-sheet combination. In particular the temperature dependency of the mass transfer, which differs from material to material, was the focus of this investigation.


This chapter focuses on the concept of the Mashriqu'l-Adhkar in Baha'i thought and practice, and explores the interplay between the universal specifications for this particular architectural form and its enculturation in regional settings. It explores the extent to which their emergence models the "six facets of production" that Peterson and Anand suggest underlie effective "production of culture". The first section of the chapter reviews the conception, design, and construction of Houses of Worship; second section focuses on matters of use and receptivity. Eight Houses of Worship were built in the twentieth century (Ashqabad, Wilmette, Kampala, Sydney, Frankfurt, Panama City, Apia, and Delhi), and more than one hundred additional sites have been acquired globally for future construction. Since few of these dependencies have been as yet developed, this chapter focuses on the construction of Mashriqu'l-Adhkars in the twentieth century, and on their subsequent evolution as newly created sacred spaces. Keywords:Apia; Ashqabad; Baha'i; Delhi; Frankfurt; Kampala; Mashriqu'l-Adhkar; Panama; Sydney; Wilmette


first journal on Ambient Intelligence! There is no surer way to become a fool in our industry than to make predictions about the long term future of IT so we will avoid that here but we do have a firm belief that this international journal will be sounding board for much of the cutting edge research in Ambient Intelligence and ubiquitous computing in the near future. We are delighted to have serving on our editorial board, the most influential figure in the Ambient Intelligence space – Prof. Emile Aarts who is currently Vice President and Scientific Program Director at Philips Research Laboratories. Prof. Aarts has been leading the way for over 12 years now and all who have had experience of his HomeLab project will testify to its groundbreaking nature. We are also thrilled to have other internationally recognised experts onboard such as Yang Cai of Technology) among others. This journal is indebted to those who have volunteered for editorial review duties. The success of the journal depends entirely on the selfless contributions from the editorial board and we thank all those who are serving. There are of course many definitions of Ambient Intelligence (AmI). To add another, we could say that Ambient Intelligence has the awareness of specific characteristics of human presence and personality dealing in turn with user needs, responding intelligently and all the while – remaining invisible to the user (unless necessary) and striving to ensure that any interactions should be of minimal effort, easy to understand and ultimately enjoyable. Now, if you really think about that statement and the checklist of aspects which need to be satisfied – then you could be forgiven for thinking that it is a fantasy. That however it can be argued, is why a journal such as IJACI exists. Of course, the vision of Ambient Intelligence is difficult but here in these pages is where we expect to see the vision become a reality. Ambient Intelligence refers to the environment of computing which is aware and responsive to the presence of human interaction. The aim is to use the space surrounding us in the form of movement, shape and sound recognition and create a system that will be able to recognise all the different scents that are in the environment. Ambient Intelligence has been influenced by user centred design which is an approach to design which regards the user's needs as …


FIELD: medicine. SUBSTANCE: group of inventions relates to medical equipment. Laser device for depilating has base unit and held in hand laser case, which has shape of rod. Laser generates light pulses, which have energy and duration, sufficient for injuring papilla of each hair follicle, which is in the way of beam. Device is provided with one or several safety units for prevention of occasional violation of conditions of its exploitation. In particular, into device introduced is highly intensive light-emitting diode, due to which person looking at future trajectory of laser beam has unpleasant sensation, created by blink reflex. In addition, device can be provided with sensor of contact/clearance with skin and/or one or several blocking means. EFFECT: by means of sensor prevented is application of laser taken away from skin, with blocking means prevention accidental supply of power to laser. 27 cl, 5 dwg


Acute {gamma}-irradiation of rats at doses of 100 and 270 Gy stimulates lipid synthesis and changes the lipid composition of liver cell organelles. The content of cholesterol and cholesterol esters in microsomes increased at 100 Gy and decreased at 270 Gy, with total phospholipid content remaining unchanged. The lipid content in mitochondria decreased considerably 1 h after irradiation at 270 Gy. This change was significantly less pronounced 47 h later. Under chronic {gamma}-irradiation (0.129 Gy/day), cholesterol and cardiolipin in mitochondria increased. The changes in lipid content caused by acute irradiation are presumed to be related to activated synthesis of lipids in the liver. The modification of the lipid content of mitochondria observed in chronically irradiated rats may indicate that energy-metabolizing liver cell systems are involved in the adaptation to irradiation.


Non-point source (NPS) contamination in the context of surface and ground water interaction was investigated in the Elbow River, Alberta, Canada. Groundwater flow direction, water table elevation, baseflow recession, chloride, nitrate and microbiological measurements were made to determine the interaction of several small tributaries and a small hamlet with Elbow River-associated groundwater. Groundwater flow in the alluvial aquifer adjacent to the Elbow River is predominantly subparallel to the river, but can vary seasonally by as much as 30°. Bedrock constricts the alluvial aquifer downgradient of the tributaries and the hamlet, causing groundwater to emerge into the Elbow River at this point. Chloride mass flux estimates suggest that septic effluent from the hamlet enters the groundwater immediately downgradient of the hamlet and discharges to the river from 5 to 12 km downgradient. A tributary creek which joins the Elbow River just above the bedrock constriction also contributes significant chloride to the river, and had significantly higher bacterial loads than the Elbow River, suggesting that land uses on this creek are also a significant source of contamination. Geologic sources, cattle grazing on the alluvial aquifer, road salting, golf course fertilizer use and wildlife are also potential contaminant sources.