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|View Poll Results: Toradora! - Episode 24 Rating
|Perfect 10
|9 out of 10 : Excellent
|8 out of 10 : Very Good
|7 out of 10 : Good
|6 out of 10 : Average
|5 out of 10 : Below Average
|4 out of 10 : Poor
|3 out of 10 : Bad
|2 out of 10 : Very Bad
|1 out of 10 : Painful
|Voters: 217. You may not vote on this poll
|Thread Tools
|2009-03-25, 18:17
|Link #561
Junior Member
Join Date: Mar 2009
I was pretty surprised by this episode, and after reading through this thread I'm glad to know I'm not the only one.
In anime there's always areas where you're expected to suspend belief, and other areas where a tie to reality makes it interesting and watchable. In the case of Toradora, one of the areas where a tie to reality is maintained was the relational interactions between the characters, the chain of cause and effect, motivations of love and friendship, and I guess in general, the human emotions involved in their everyday actions. This episode seemed to trample on that reality when Ryuuji and Taiga decide to
Spoiler for toradora 24:
Why? Doesn't this sort of thing happen everyday in the real world? Yes, but given the motivational factors behind their decision to
Spoiler for toradora 24:
Okay, young people in love do stupid things... I guess that's true. And I read somewhere that kids in Japan grow up slower (that is, are slower to become independent, to live by themselves, to take care of themselves, etc.) than their western counterparts. But still, over the series of Toradara you grow to care for Taiga and Ryuuji and the other characters, you feel connected to them, and in the end it's very frustrating when they end up doing something utterly idiotic.
I suppose it's not entirely irrational to believe such a storyline. Epic, venerable tales have been written around such events. But I'd say the sense of betrayal, at least for me, comes from being sold on Toradara as a light hearted romantic school life comedy, with this turn of events seemingly bringing the anime into a totally different genre... almost like a bad soap opera.
|2009-03-25, 19:15
|Link #562
Senior Member
Join Date: Oct 2007
Location: Washington State
And now suddenly over something as stupid as him wanting to work to help her out makes him move out and her disappear? There was no set up to that at all, there was one or two conversations about her wanting him not to work, but never anything to this extent. It's like the author just wanted a big twist at the end, but sorry I don't buy twists for thier own sake. It's shoddy writing and lazy, and no matter what context I strongly disagree with that type of storytelling. It's like writing a mystery story but never giving a single real hint to who the perpatrater is, well then OF COURSE it's going to be a surprise at the end.
|2009-03-25, 19:37
|Link #563
Senior Member
Join Date: Oct 2006
Location: USA
They have hinted at it quite a bit actually, but it was most blatant in the previous episode after Yasuko got sick.
"Why can't she rely on me?" When he had his mini-freakout it was because Yasuko refused to rely on him and took all the responsibility on herself.
I sometimes have had trouble understanding character motivation in this show but this conflict/love he had with his mom is something I saw as very true and relatable to me as I too came from a single-parent home. Everything I've read so far in the books has had me nodding along, sometimes crying a little bit and the show actually toned it down if anything rather than blowing it up more. So it bugs me a bit when you call this aspect of the story "shoddy writing". He isn't angry at her, quite the opposite. He lives to please her but she refuses to accept any real help from him that might lead to sacrifice on his part and he resents that.
Also, he didn't leave home just because of his fight with Yasuko but to go with Taiga who didn't want to be taken by her mom remember.
|2009-03-25, 19:47
|Link #564
Senior Member
Join Date: Oct 2007
Location: Washington State
They hinted that there was a little issue, not a "I'm going to get married and run away, then she disappears and just leaves a note" kind of issue. It just seems it was waaaaay too big of a reaction to a rather small issue. It seemed very unnatural and forced, which to me really stood out because I thought a lot of the character interactions so far seemed very well done and believable. This however just seemed fake to me.
|2009-03-25, 19:57
|Link #565
Senior Member
Join Date: Oct 2006
Location: USA
Again, the fight with Yasuko wasn't the reason he's running away, her complaining about the job was merely the catalyst to get him to tell her off. Look at his face when he sees that he made her cry, he instantly regretted saying it.
He makes it pretty clear when he's talking to Taiga on the bridge that he isn't even angry at her, he's angry at himself for putting her into the situation she's in. ("It'd be better if I wasn't born.") He thinks (At that point in the story) that if she didn't have to worry about him she'd be happier and would be able to lead a better life, possibly even reconciling with her parents. That part might seem stupid/emo to you but everyone has moments of self-pity like this.
|2009-03-25, 20:37
|Link #566
Junior Member
Join Date: Dec 2005
I also disagree with "running away was too sudden". For people to appreciate that, they need to understand the single-parent family, along with many other character traits...
The fact that Ryuuji is mature and stands/thinks on his own very much more than his peers is also a huge plus. Add his age - that he's old enough to do a lot of things - and his resentment at not being able to do anything for himself - as demonstrated clearly in the previous episodes with flashbacks and with Taiga - and it's something coming.
Animes do not flash scenes at all if they aren't important. The timeframe is too short to waste on that, especially in a packed final few episodes.... If you re-watch the series, you would probably pick up the clearly dropped hints all over.
So for me, was Ryuuji out of character? No. Was anybody else out of character? I safely say no. Was the epiosde a surprise because it was chock full of content? Yes.
|2009-03-26, 11:07
|Link #568
Join Date: Jan 2009
Location: DP 原画 --> ヨハネ
Sort of knew what this episode would cover already but loved it nonetheless. Can't wait for the final to air here. I'll definitely miss this show and I can say that it is the best anime of 2009 to date.
|2009-03-26, 11:32
|Link #569
Senior Member
Are you even old enough to understand the meaning of "jumping the shark"? Real people don't act the exact same every day, we sometimes react badly to things that bother us. I don't see how fictional characters would be any different.
|2009-03-27, 11:25
|Link #571
Senior Guest
Join Date: Jan 2009
Location: Athens (GMT+2)
Age: 30
I liked this episode a lot, rated 10/10. The mist has finally cleared, Takasu is with Taiga and more importantly everyone's ok with it
btw...maybe it's the white clothes, but does anyone else think that Taiga looks like Orihime at 22:36? 0_o
|2009-03-29, 11:48
|Link #572
Senior Member
Last edited by Baka Ronin; 2009-03-29 at 11:49. Reason: MOAR
|2009-03-29, 12:59
|Link #573
Join Date: Jan 2006
Location: In a house
In the third picture of my signature, I think Taiga looks a bit like Hagu from Honey and Clover. What do you think?
|2009-03-30, 19:18
|Link #574
like to talk to fish?
Join Date: Feb 2009
|2009-04-18, 05:26
|Link #578
My posts are frivolous
Join Date: Nov 2008
Age: 29
I was rewatching the series, and in episode 3, Minori said, "A nosebleed is your heart's sweat!" (AnimeYoshi subs) when she and Ryuuji were trapped in the storeroom and she was hit by a falling box.
She changed it to "A nosebleed is the crying of the heart" in this episode. Since she got a nosebleed while sweating, and now while she's crying, it seems to allude to an association with her hard work and her true feelings. Perhaps part of the reason for her industrious attitude is to hide her feelings, though the main reason is still to get into a sports university.
|Thread Tools


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Long after learning that a troubling reading on a screening mammogram was just a false alarm, women continued suffering negative psychological effects, researchers in Denmark have reported.
Six months after hearing they did not have breast cancer, women with these false positives experienced changes in "existential values" and "inner calmness" as great as for women who had cancer. They reported having more anxiety, feeling more pessimistic and having more problems with their sleep and sex lives — as well as other negative outcomes — than women who had normal mammograms.
The effects moderated over time but were still apparent three years after the initial screening.
The findings suggest that healthcare providers need to pay closer attention to the harmful effects of screening programs, said University of Copenhagen physician-researcher Dr. John Brodersen, lead author of a study detailing the work published Monday in the journal Annals of Family Medicine.
"When I became a doctor and I took the Hippocratic Oath, I said, 'Do no harm,'" he said. "But this is harm."

subset: commoncrawl


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Eva Marie Flint Murray Windham passed away May 23, 2011, in Denver, Colo. She was born in Dee, Ore., on Oct. 2, 1912, and lived in Hood River for 88 of her 98 years.
She is survived by her daughter, Christie, and beloved son-in-law, John Faires, of Aurora, Colo.; sister-in-law, Luanna Flint, of Hood River; nieces and nephews Diane and John Kerr, of The Dalles, Doreen Flint, of California, Doug and Edie Flint, of Florida, Leslie and Dick Gohlman, of Arizona, and Judee Flint, of Mosier.
She was preceded in death by her parents, Anton and Minnie Flint; brothers Howard, Leland and Robert Flint; and sisters Lottie Farra and Verna Davey.
Eva loved reading, crossword puzzles, gardening, ice cream, watching football and golf and Bud Light. She missed her many friends and family in Oregon and often spoke of seeing Mount Hood again.
Eva worked for many years at Wirrick's Variety Store and she retired from the United Telephone Company as a long-distance operator. She was also a member of the American Legion Auxiliary and the Riverside Community Church.
Ten years ago, when her health required family assistance, she moved from Hood River to live with her daughter and son-in-law in Maryland, then moved with them to California, and then to Denver.
For years Eva was the picture of great health. Never having a driver's license, Eva would walk to work, the grocery store, church and to other activities. Even in retirement a walk of 3 miles daily was not uncommon while in her 80s.
She was a remarkable mother and friend and will be missed by all who knew and loved her.
Cremation took place in Denver and interment will be at Idlewilde Cemetery in a private family service to be held at a later date. The family has asked that in lieu of flowers, if you wish to remember Eva, please hug someone you love.
Information from the News and our advertisers (Want to add your business to this to this feed?)


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To some the idea of mixing a romantic relationship in a professional wrestling storyline might seem a bit odd, yet historically they've proven very successful at capturing the audience's attention. Yet, it's been quite a while since the WWE has involved a romance into any of their main storylines or angles despite the recent marriage between Tyson Kidd and Natalya Neidhart, the engagement of Jimmy Uso and the Funkadactyls' Naomi, the continuing marriage between Triple H and Stephanie McMahon, and Daniel Bryan and John Cena each dating one of the Bella twins.
The closest there has been to mixing romance into a featured WWE storyline in recent times was in 2011 and 2012, when AJ Lee was paired up with Daniel Bryan, CM Punk, Kane, John Cena, and eventually Dolph Ziggler. However, since WWE matched Lee with Ziggler the onscreen romantic element has kind of faltered and been dropped.
What makes all of this quite strange is that involving romantic aspects into wrestling storylines have been a big draw in terms of ratings and attention, plus it's an effective way to get over all the wrestlers involved in a storyline.
Who can forget Rick Rude coming on to Jake Roberts real-life wife Cheryl (now divorced) in 1988? The resulting feud between the two was huge and it was all because of the WWE allowing a real-life romantic element to be used to kick off the feud. Why did it work? Well almost anyone who has ever been in a serious relationship can relate to what it feels like to have someone hit on your significant other. Thus, it was easy for fans to put themselves into Roberts' headspace and boo mercilessly Rick Rude.
Yet, that wasn't even the biggest WWE storyline involving romantic relationships during that era. The Randy Savage and Miss Elizabeth storyline lasted for years in the WWE in the 1980s and 1990s and later continued in WCW. The adding in of their real-life marriage and subsequent divorce to on-screen elements resulted in fans truly being engaged in their storylines. It also allowed Savage to show multiple sides of his personality to the audience including arrogance, jealousy, protectiveness, caring, self-improvement, sensitivity and strength. In fact it was Savage's real-life jealousy, as far as Miss Elizabeth was concerned, that ignited the fuse that kicked off the Mega-Powers explosion which later on climaxed at the main event of WrestleMania 5 between Savage and Hulk Hogan.
If you look back at WrestleMania 7, the biggest reaction of the night from the audience came when after having lost the match to the Ultimate Warrior and having Sensational Sherri pummeling him afterwards, Miss Elizabeth rushed to the ring to save Savage; the reunion was one of the night's highlights. The Randy Savage/Miss Elizabeth would be front and center the following year at WrestleMania 8, when Ric Flair famously exclaimed, "She was mine before was yours!" to Savage. Their match at that year's WrestleMania was probably one of the best, if not the best on the card, and it would later play out in WCW. All of that likely wouldn't have been possible if Savage's feelings for Miss Elizabeth hadn't been used on-screen.
Speaking of WCW, a large part of widening Diamond Dallas Page's appeal to the wrestling audience was when they finally acknowledged that he was married at the time to Kimberly, the leader of the WCW Nitro Girls. All the sudden this connection, and Randy Savage and the New World Order's subsequent attacks, created a kind of vulnerability to Page which allowed the audience to instantly get behind him in a way they never had quite done so before. It made for one of the most electric feuds in WCW in 1997.
In 2005 and 2006, probably the hottest storyline in the WWE was the feud between Matt Hardy and Edge over Lita. For those who may not recall, Matt Hardy and Lita were a real-life couple for many years. However, when Hardy was injured for a while and off the road, Lita and Edge ended up starting a romance before she had broken up with Hardy. This spilled over into the public eye, and led to Hardy being let go by the WWE in April of 2005. However, every time Lita and Edge would appear before an audience the fans would chant at them "You screwed Matt," so eventually the WWE brought Hardy back in July of 2005 to start the white-hot feud. The audience was charged up for this feud as it was so relatable to just about everyone. While it might not have been Edge's or Lita's first choice to have their personal life played out in public, it probably resulted in the WWE storyline for which they are both best remembered by many fans today.
So why might the WWE not being using the real-life romantic relationships as part of their on-screen storylines nowadays? Well, part of it may be due to the fact that having your relationship depicted in the public eye probably isn't the healthiest thing for its future. After all, pretty much every past couple mentioned as an example in this editorial eventually broke up, so many of those in the WWE today are likely aware of that fact and are reluctant to deal with bringing that level of attention to their romantic relationships.
Still, it's going to be difficult to avoid the intermixing of reality and wrestling storylines being that the Bella twins, the Funkadactyls and Natalya Neidhart are featured in WWE's new reality show Total Divas, and the early buzz is that their real-life romantic relationships will be part of what viewers see and hear on the television screen.
Eventually, the audience reaction at RAW and Smackdown is going to bleed over, and if the rumours about an upcoming feud between John Cena and Daniel Bryan comes to fruition, it will be very difficult to avoid their respective real-life romantic relationships with Nikki and Brie Bella. If wrestling history is any judge if they intercut it in correctly the WWE could be looking at one of their biggest feuds in years.
Matthew has been on a break from dating these last several months, but is considering getting back out there again. Check out Matthew's advice column The Male Perspective.


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I tried for hours and hours to find a good, simple code to make it possible for me to open a URL or send an e-mail from a link edited in a TextBox and not assigned in a LinkLabel. The answer is very simple: Just add the following code to a click event in a button:
Private Sub Button1_Click(ByVal sender As System.Object, _ ByVal e As System.EventArgs) Handles Button1.Click System.Diagnostics.Process.Start(TextBox1.Text) End Sub
The contents of the text box must be http://www.something.com or mailto:email@example.com. Your default browser or mail application will open and perform the requested action.


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SACRAMENTO — A California man accused of trying to travel overseas to join an Islamic terrorist group to fight in Syria and Iraq is undergoing continued mental testing as prosecutors and his defense lawyers seek a resolution to his case.
The Sacramento Bee reports (http://bit.ly/1uW6alC) 20-year-old Nicholas Michael Teausant appeared briefly Tuesday in federal court, where prosecutors said the case involved classified information.
Teausant has pleaded not guilty to terrorism charges. His lawyers said in court filings that he is "a lonely, mentally ill young man" incapable of providing support to a foreign terrorist organization.
Prosecutors say the community college student talked to an informant and an undercover FBI agent about joining a terrorist group.
He was ordered to return to court in October after undergoing additional mental testing.
Information from: The Sacramento Bee, http://www.sacbee.com


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Tuesday June 12, 2012
Here is the first look of the gorgeous Olivia Palermo as Rochas' new muse.
The socialite is fronting the latest campaign for the French fragrance brand.
"The campaign embodies everything I expect from a fragrance and a brand," says Olivia. "It shows that every woman can feel confident as long as she takes time to enjoy life."
She was delighted with the making of the commercial. "The shooting in Paris was very special; I think women have an innate sense of their own style," she said.
"I love discovering incredible places where I can stop and see how time goes by. There are many hidden treasures to be found!"
Read full story


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Alibi Picks
FemCity Connection Lunch
They say that good deals and great ideas happen over food, which is why a professional lunch can have many opportunities. FemCity Albuquerque will host author Jessica Eaves Mathews at a connection luncheon tomorrow at Savoy Bar and Grill (10601 Montgomery). At the event, Matthews will discuss her book, Wonder Women: How Western Women will Save the World, with the public and, true to the book's mission, aims to empower and motivate local women. The book frankly discusses politics, the national debt and economic issues rooted in the customary approach to business. After a drawn out government shutdown and an only increasing national debt problem, maybe some practical local solutions and a change of mind would do the community a little good. The connection lunch begins at 11:30am. FemCity Albuquerque members can buy tickets for $45 and others can purchase them for $55. Tickets include an elegant lunch—complete with a glass of wine—and a raffle. For more information on the event or Femfessionals Albuquerque, visit femfessionals.com or FemCity Albuquerque's Facebook page. Savoy Bar and Grill • Fri Nov 1 • 11:30am • $45 for FemCity members, $55 for non-members • View on Alibi calendar


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By John Goralski
Sports Writer
Coach Mike Forgione's game plan focused on Suffield guard Merideth Ouellette even though few fans in this part of the state have ever heard her name. From the opening whistle, the Lady Knights swarmed the 5-foot-6 junior. They stepped in passing lanes and waved hands in her face whenever possible.
That's why her 13-point surge in the opening quarter came as such a surprise. Ouellette was shadowed, contested, and double-teamed, but she still managed to go 5-for-5 in the opening quarter. Even with hands in her face, Ouellette managed a trio of three pointers and 13 points before the first horn.
"We focused on her right away. We were playing her man-deny. We were trying to deny her even getting the ball, but she took five shots in the first quarter and made every one," said Forgione. "It wasn't like we weren't prepared or they caught us off-guard. Give Suffield credit."
Forgione knew that his inexperienced team wouldn't finish the season undefeated, but he still couldn't hide his disappointment about the 59-49 road loss on Friday, Dec. 27. After upsetting Newington at the start of the season and rolling out to a 4-0 loss, he was hoping that momentum would carry through the new year.
"Give Suffield credit. They were really aggressive, and I think we learned that we have to match that intensity," said Forgione. "I don't think we lost to a bad team. We gave the effort, but the kids understand the intensity we need going forward if we're going to compete in our conference."
On the other hand, Forgione said that he was pleased with the effort. Despite Ouellette's first quarter hot streak, the Knights were able to limit her to just 12 points the rest of the way.
Two more Wildcats managed to score in double digits with an inside-out game, but Southington was able to battle back to tie the game late in the fourth quarter.
Sure, the Knights fell to 4-1 with the loss, but the game was close until the final minutes. At times, the Knights were competing with two freshmen and a sophomore on the floor, while Suffield countered with an experienced roster of upperclassman.
Forgione said that balanced efforts and determination are going to be the keys to this year's success.
"We know that, if we are going to win games, it has to be a total team effort," said Forgione. "I'm happy with the way that we fought back. We're not going to go one-on-one against many teams with one girl scoring 40 points to carry us. Everyone had to do their job and work for each other."
Once again, Natalie Wadolowski rose to the challenge. The sophomore was charged with stopping Ouellette down the stretch but still managed to score 20 points with seven rebounds. Sarah Mongillo anchored the middle with 13 rebounds and three steals. Maggie Meehan finished with 11 points and five assists. Kaitlin Paterson (8 points) and Nicole Fischer (6 points) both contributed to the balanced attack.
"I was happy with our effort," said Forgione. "It came down to shots late in the game and free throw shooting."
The loss came on the heels of a 46-33 conference victory over Conard that pushed the Knights to 2-2 in the CCC West. Southington rolled out to an 18-9 lead at the end of the first quarter and cruised to a 13-point victory.
"We talked about starting strong, and Kaitlin really came out right off the bat. She had two threes and 10 points in that first quarter," he said. "We got that lead up to double digits at the half, and we really never looked back in the second half."
Paterson paced the locals with 16 points, including 2-for-4 shooting from long range. Wadolowski scored a double-double with 15 points, 12 rebounds, four steals, and two blocks. Meehan scored seven points and led the fast break with seven assists.
Southington has one more chance to score their fifth win before January with a New Year's Eve matinee against Maloney. Then, the pressure will be turned up with a tough non-conference match up against Plainville before jumping into fray of Southington's conference schedule.
Forgione continues to look for balance and effort to carry his young team into the postseason.
"We need to take it one game at a time. I know it's a cliché, but with this group it really is true," he said. "Even if you're not doing one thing well, we're going to need everyone to make that up with other things. Everyone's going to have a poor shooting night. Everyone's going to have nights when they're not on, but you can always play aggressive defense. You can always make good passes or see the floor."
The Knights aren't even close to their potential, and that's good new for Southington fans.
To comment on this story or to contact sports writer John Goralski, email him at email@example.com.
Learning from the loss; Lady Knights battle against Suffield's experience
By John Goralski


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Remember my club i kept going on about? well at the moment i'm in the process of getting a new larger room and 30 mins extra club time, meaning i'll have altogether 1:20mins altogether for setup & game time. but i need scenario's that can fit that time frame to be played by 2-4 players that can be done with limited parts and are fun to play. Any ideas from old battles will be welcome!
Scenario's so far:
Team hero deathmatch (what RJ's doing)
Squad CTF


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The G650GS is capable on the highway and nimble enough hold its own on the trail. Give it a proper footprint with a side stand foot from AltRider. The side stand foot prevents the bike from tipping over when parked on soft or uneven ground – taking the worry out of parking on dirt, mud, gravel and even hot pavement.
Constructed from rugged 1/8" (3.2 mm) stainless steel, the AltRider side stand foot will never rust or weather. It's clamped to the side stand with 5 torx fasteners to prevent it from rattling loose – no matter how rough the trail gets. The ergonomic design features an aggressive 3D tread that is easily deployable, even while wearing riding boots. Available in shot peen silver or powdercoated black.
-Fits both factory lowered and standard height suspension models
-All AltRider motorcycle accessories are 100% designed and manufactured in the USA
-Made from 1/8" (3.2 mm) stainless steel
-Torx fasteners prevent foot from rattling loose even after months of riding
-Available in shot peen silver or powdercoated black
Note: Fits all years F650GS single and G650GS without factory lowering kit. Does not fit Dakar or Sertao. AltRider products cannot be shipped to Canadian addresses.
AltRider G650GS Sidestand Foot
Produced by AltRider of USA


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Back in 2009, I knew nothing about this blogging thing. Honestly, I'm not even sure I really knew what a blog was. But suddenly there I was jumping head first into this world. 4 years later, I still can't tell you much about some parts of blogging like SEO and hosting (which is why at this very moment I'm currently reading Food Blogging For Dummies), but I can't even begin to imagine what I'd be doing if I weren't right here right now, doing this whole deal.
Every now and then when I'm bored I go back and read through some of my old posts. Talk about cringe worthy! Wow. Just wow. Some of those.. *sigh* Not only were the posts a ramblefest but the pictures! Oh the pictures. It's like looking through your middle school yearbook. You just want to forget it ever happened. So, in honor of this little blog's 4th birthday, I thought it would be fun to take a little trip down memory lane and show you the good, the bad, but mostly the ugly of the last few years!
|There was an unfortunate slant phase. I don't know why.. but it lasted for well over a year--much like my permed hair phase.
|I'm ready for my closeup.
|Are we at the pool? Why do I feel like swimming?
|What is this? That's it. I'm firing my food stylist.
|Well that's appetizing..
|Oh. Oh wow.. That's just.. sad.
The original recipe was marbled peanut butter and chocolate cake--neither of which had much flavor. The underwhelming cake was topped with an overwhelming peanut butter cream cheese frosting. Blegh. It was definitely time for a flavor upgrade.
Using my tried and true chocolate cake recipe, I topped it with a swirl of peanut butter and chocolate frosting. The peanut butter was a bit softer than the chocolate, so it didn't swirl quite as well as I'd envisioned, but one bite, and you'll forgive all its aesthetic imperfections. No tangy cream cheese flavor here--it's nothing but peanut buttery goodness.
After looking at all the terrible pictures that litter my little slice of internet life, I think I might have to revamp quite a few of my recipes and reclaim a bit of my dignity. And here's to hoping that I don't cringe at these pictures 4 years from now.
Peanut Butter Cup-cakes
Adapted from Food Network
Makes 12 cupcakes
1 cup cake flour
1/4 cup unsweetened cocoa powder
3/4 teaspoon baking soda
pinch of salt
1/2 cup granulated sugar
1/2 cup real mayonnaise
1/2 teaspoon vanilla
1/2 cup buttermilk
3 egg whites
3/4 cup granulated sugar
3/4 cup (1 1/2 sticks) unsalted butter, room temperature
1 teaspoon vanilla extract
pinch of salt
2 tablespoons peanut butter
1 1/2 tablespoons unsweetened cocoa powder
6 mini peanut butter cups (optional)
1. Preheat oven to 350F. Line a standard muffin tin with paper liners; set aside.
2. In a medium bowl, sift together flour, cocoa, baking soda, and salt; set aside.
3. In the bowl of an electric mixer, beat mayonnaise and sugar until smooth, about 2 minutes. Add vanilla extract and beat to combine. Add flour mixture to sugar mixture in three additions, alternating with the buttermilk, scraping down the sides of the bowl as needed.
4. Pour batter into prepared tin, filling each cup about 2/3 of the way full. Bake, rotating pan halfway through, until a toothpick inserted in the center of the cake comes out clean and the tops spring back when lightly touched, about 18 minutes. Let cool in the pan for 10 minutes, then remove and transfer to a wire rack to cool completely.
5. While cupcakes are cooling, make frosting: In a medium heat proof bowl set over a pan of simmering water on the stovetop, whisk together egg whites and sugar until sugar has dissolved and mixture is warm to the touch, but not too hot (about 160F).
6. Remove from heat and transfer mixture to the bowl of an electric mixer fitted with the whisk attachment. Whip egg white mixture until stiff peaks form and the bottom of the bowl is cool to the touch, about 7 to 10 minutes. (Mixture will have the consistency of melted marshmallows.) Reduce speed to low and switch to the paddle attachment. Add butter, a tablespoon at a time, beating well after each addition. Increase the speed to medium-high, and continue beating until frosting becomes thick and fluffy, about 3 to 5 minutes. (It will break apart and look curdled at first, but keep beating. It will all come back together. If it still looks a bit soupy after several minutes, place mixture in the fridge for 10 minutes to chill and try again.) Add vanilla and salt and beat until well combined.
7. Divide frosting in half, placing half in a separate bowl; set extra bowl aside. Add 2 tablespoons of peanut butter to the remaining frosting and beat until well combined and fluffy. Transfer to another bowl and set aside.
8. Place the plain frosting you set aside back into the clean mixing bowl and add 1 1/2 tablespoons of cocoa powder. Beat until well combined and fluffy.
9. Place peanut butter frosting in one side of a large piping bag fitted with a round or star tip, and place chocolate on the other side. Pipe onto cooled cupcakes. Cut mini peanut butter cups in half and place on top.
*Note: Or you could just skip the swirling altogether and make a peanut butter/chocolate frosting from the start, adding both ingredients to the bowl at the end of step 6.


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Fun at Northstar | August activities include summer concert, National Sand#8217;mores Day, and more
August 6, 2012
TRUCKEE, Calif. and#8212; With a calendar full of new and returning special events such as Star Sessions, the Northstar summer concert series, and outdoor activities like Tahoe Star Tours and the Northstar Mountain Run, thereand#8217;s something for all ages and abilities.
Tahoe Star Tours
Shooting stars and comets, select Fridays and Saturdays
Star guide, poet and avid astronomer Tony Berendsen will lead an exciting intergalactic and educational night under the stars select Fridays and Saturdays in August. While each tour offers a unique interactive experience, all feature a poetry reading, space quiz and laser tour of the unobstructed starry skies of the Sierras. Participants will have the opportunity to look closely at the moon and any planets that may be visible through Berendsenand#8217;s Celestron telescopes. Adult tickets are $30 and child tickets (12 and under) are $15.
String quartet to play
On Saturday, Aug. 18 the Accent String Quartet, a Reno-based string quartet featuring cellist Dr. Eileen Brownell, will make a special appearance. Guests will enjoy hot chocolate and coffee while listening to the enchanting melodies and viewing the stars above. Tickets for this special event are $65 for adults and $30 for children (18 and under).
Recommended Stories For You
National Sand#8217;mores Day celebration
Northstar will celebrate Americaand#8217;s favorite campfire treat, the sand#8217;more, on National Sand#8217;mores Day, Aug. 10. In honor of this tradition, complementary sand#8217;mores will be offered throughout the day to resort guests. And, in the evening, guests are invited to enjoy the free outdoor film screening of a Disney summer classic, Heavyweights (rated PG).
Lake Tahoeand#8217;s All Women Sports Camp
Women of all ages and athletic abilities are in invited to participate in Lake Tahoeand#8217;s All Women Sports Camp for a weekend of inspiration, camaraderie and fun, Aug. 10-12. With a roster of professional women athletes and instructors, 22 clinics and group activities, the all womenand#8217;s camp allows women to share knowledge and build confidence in outdoor endurance sports such as cross country, mountain biking, road cycling, triathlon, running, stand-up paddling, downhill mountain biking and rock climbing, just to name a few. More information and registration can be found at http://www.allwomensportcamp.com
Northstar Mountain Run
Big Blue Adventure will host the 5th Annual Northstar Mountain Run on Sunday, Aug. 12. The 10.2K single and double track course starts at the Village at Northstar and finishes at the top of Mt. Pluto. Racers will enjoy scenic views of Lake Tahoe, wildflowers and the Sierra while taking on the challenging, gradual climbs until they reach finish line at 8,610 feet. Interested participants can register online in advance, or at the resort the day of the race.
Star Sessions
Northstar Concert Series featuring Don Felder of The Eagles
Guests are invited to enjoy the final show of the Northstar Summer Concert Series Aug. 17, featuring Don Felder, former lead guitarist of The Eagles, in the Village at Northstar, one of the newest, most intimate live music venues in Tahoe. Felder, a member of The Rock and Roll Hall of Fame since 1998, served as a key member of The Eagles for 27 years and was the originator and co-writer of The Eaglesand#8217; biggest hit and#8220;Hotel California.and#8221; Pre-sale general admission tickets can be purchased online for $18 or the day of for $23. Doors will open at 6 p.m., with the show starting at 8 p.m.
Village at Northstar Wine Walk
Stroll through the Village at Northstar while enjoying live music, hors d'oeuvres, and a variety of wines from the North Coast Region Aug. 28. Participating stores in the Village will offer tastings of fine wines from regions including Sonoma, Mendocino County, Anderson Valley, and many more. Pre-sale tickets are now available online for $25, day of tickets will also be available for $30. All tickets include a commemorative wine glass.
and#8220;Wheely Tuesdaysand#8221; featuring STRIDER Adventure Zone
The new STRIDER Adventure Zone is the perfect opportunity for budding young cyclists (ages 18 months to 5 years) to enjoy the challenge and thrill of riding on unique terrain with fun obstacles. Every Tuesday (through Aug. 28), noon-4 p.m., children are invited to ride their own, or test ride a STRIDER balance bike on the skating rink in the Village at Northstar. A limited number of STRIDER bikes will be available at Plaza Bikes on a first-come, first-served basis.
Retro Skate Night
Guests are invited to pull out their bell bottoms, practice their best and#8220;shoot the duck,and#8221; and groove on the rink with music from the 70s and 80s, 6-9 p.m. The DJ will host skating games throughout the evening, with winners receiving prizes. Event access is complimentary, and skate rentals are available for just $10.
For further details, or to purchase tickets online for any of Northstarand#8217;s 2012 summer events, call 800-GO-NORTH or visit http://www.NorthstarCalifornia.com.


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NCAA On Campus Features Kevin McCarthy '12by Brent Harris • December 13, 2010 Share:
NCAA On Campus visited the Wabash College campus a few weeks ago to produce a video feature on junior cross country and track and field athlete Kevin McCarthy.
The video features McCarthy's summer internship working with a medical program in rural Appalachia. McCarthy left Indiana 24 hours after competing at the 2010 NCAA Division III National Championship Track and Field for Hyden, Kentucky. He worked as a volunteer with the Frontier Nursing Courier Service, assisting in a program in which medical professionals provide primary care for people in the Leslie County area.
View the video here.
"It was an extraordinary experience, one that further increased my interest in primary medicine as well as the service in rural medicine," McCarthy said. "Leslie Count is very rural — the entire county has approximately 12,000 people total. Beyond my work with the Frontier Nursing program, it was a month of rich study of generational poverty, and American backwoods religion and history seated in the land of coal country. It is a different culture than here. I felt as though I had traveled back in time almost 50 years."
NCAA On Campus spent time in the classroom and at cross country practice with McCarthy. Senior Kyle Grand served as the host for piece.


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In September 2008, just two days after the Lehman Brothers' collapse, the Federal Reserve shelled out $85 billion to AIG to prevent bankruptcy. The Fed made a deal to own 79.9 percent of AIG. The CEO was dismissed and the Fed charged AIG 8.5 percent interest for the loan. AIG had written billions of credit default swaps (protections for banks), and their demise would have caused billions of writedowns throughout the world's economies.
In September 2008, just two days after the Lehman Brothers' collapse, the Federal Reserve shelled out $85 billion to AIG to prevent bankruptcy. The Fed made a deal to own 79.9 percent of AIG. The CEO was dismissed and the Fed charged AIG 8.5 percent interest for the loan. AIG had written billions of credit default swaps (protections for banks), and their demise would have caused billions of writedowns throughout the world's economies.
"Too big to fail" became the mantra. The argument that AIG shareholders will put before the courts will be an interesting one. One that will challenge The Federal Reserve Act of 1913. Particularly noteworthy will be the interpretation of the section of the act, (Section 13.3), "unusual and exigent circumstances."
We all now know that the bankruptcy code only allows Wall Street bankers at the bankruptcy table (no seat is allowed for shareholders, employees, etc.), and we can thank Newt Gingrich and the boys for that legislation. AIG shareholders are hoping for some sort of clawback provision to protect their long lost interest. What is interesting is the loan the Fed gave to AIG was to prevent a bankruptcy and the question needs to be asked: In that scenario, were the shareholders protected under existing law?
Other inquiries also need to be made regarding shareholder responsibilities, including how an insurance company can allow a hedge fund to sit atop their enterprise and make very bad bets with no capitalization requirements, no oversite from regulators and awarding bonuses to top executives through contracts while the world's economies were teetering on the verge of total collapse. Where were the shareholders that stood by while Main Street got clobbered in their pension funds and the rest of AIG investments took a beating? Were there any efforts to change corporate governance?
All the losses that Main Street took on the chin because of a corrupt financial services division of AIG only fuels the anger of John Q. Public. It's been percolating for quite some time; but this will not be the legal question. The legal question will be: Did the Federal Reserve have the authority to wipe out shareholders of AIG by taking over the company that threatened the world's economies?
They did, in my opinion, as long as former secretary of The Treasury Hank Paulson signed the proper paperwork as required by law. If Paulson didn't sign, is he liable? Let's see the signature. What we the people should note is, during this fiasco, AIG was trying to get private financing by borrowing 75 billion from a syndicate of bankers so it could buy enough time to sell off some of its more lucrative insurance businesses. They were unable to do this, as there wasn't enough private capital on Wall Street willing to loan them a lifeline.
Here we can see the importance of the effort of Sheila Bair, the former director of the FDIC who proposed establishing a $125 billion fund to wind down too-big-to-fail companies. This would be funded not by the taxpayers but by the financial services industries themselves. It was in the Frank-Dodd Bill under the auspices of the Resolution Trust Authority. By the time our Sen. Scott Brown came to vote for Dodd-Frank he required that this funding be eliminated. Nice going Scotty, now we all can pay for the too-big-to-fail through taxpayers dollars.
Anyway, when AIG couldn't raise the money from Wall Street, it was downgraded by the rating agencies and the stock began to plummet, much to the dismay of the shareholders. Trading partners would no longer do business with them. Subsequent disclosures by AIG in early 2009 showed, for example, they were betting with the French bank Societe General to the tune of $4.1 billion, and with Goldman Sachs to the tune of $6 billion. AIG had also sold insurance to 100,000 big and small companies, and pension plans, municipalities and retirement plans for 30 million Americans.
By March of 2009, our tax dollars had sunk over $183 billion into AIG as AIG had exploited a huge gap in the regulatory system. Since the demise of the 1933 Glass-Steagal Act, this exploitation continues. Witness the most recent scandal with foreign derivative of JP Morgan Chase.
The initial $85 billion loan from the Fed to AIG was not part of the Troubled Asset Relief Program funding and may have a bearing on the shareholders' case. The remaining $100 billion was part of the TARP funding.


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I pretty sure it means, He has a lot of work lined up for the future :DOriginally Posted by ripley
Student or Learner
I read an interview to Hugh Grant and I couldn't understand what he meant by saying " I have fat of fish to fry"
The journalist asked: Usually when you prepare a part you read your role, rewrite it and keep to the times - you are very rigorous about comedies. Was it like that for this film (Bridget Jones's Diary) too?
he answered: I'm not difficult at all. I'm an extremely easy, nice actor to work with and it wa extremely nice for me to do this small British film, Really, I have fat of fish to fry..., and I find Richard Curtis ungrateful for his remarks. ( andso on)
Thanks. Ripley
I pretty sure it means, He has a lot of work lined up for the future :DOriginally Posted by ripley
He probably said 'a vat of fish to fry', meaning many possibilities. If someone has 'other fish to fry', they have lots of opportunities in many areas.
I agree with tdol. It should be:Originally Posted by ripley
I have a (whole) vat of fish to fry.
All the best, :D
Or a 'lot of fish to fry'. If you are reading a script that goes with a CD for learning English, Ripley, there are a lot of mistakes in those.
a lot ofOriginally Posted by Mister Micawber
Cool choice of words.
I'm a very informal kind of guy, Cass. Just wait'll I get my avatar up, you'll see. . . .
Originally Posted by Mister Micawber
to all fans of Grant
I found this picture on a site of custom celebrity photos http://www.celebrityfury.com
and i don't think this photo is part of some movie!
the direct link to Hugh Grant photo and biography:


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A young woman who was kidnapped 18 years ago in South Lake Tahoe has been found, officials announced Wednesday.
Jaycee Lee Dugard went into a police station in the Bay Area and announced her identity. She will be reunited with her mother, a resident of Riverside County later today.
Here' what the AP is reporting:
SACRAMENTO, Calif. — A woman who entered a California police station is believed to be 1991 abduction victim Jaycee Lee Dugard, who was 11 when kidnapped.
Deputies are 99 percent sure the woman is Dugard, said Lt. Les Lovell of the El Dorado Sheriff's Department. He says DNA tests were being conducted.
Witnesses reported that a vehicle with two people drove up to Dugard and abducted her while her stepfather was watching.
Lovell says two people have been taken into custody.
The sheriff's department has scheduled a news conference to discuss the case later today.


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Today I am on my way to Mesa for the Arizona Family History Expo, which starts tomorrow.
The event organizers have made it very easy for those not in attendance to follow along with some of the people who are. Here are two ways to ensure you don't miss a beat this weekend:
1. Read the posts of the Bloggers of Honor. We will be writing about the classes, the exhibits and more.
2. Follow the #fhexpo Twitter stream. You do not need a Twitter account to do this. Simply click this link for #fhexpo and you'll get only tweets about the Expo (and not all the other madness on Twitter.)
If you happen to be going to Mesa, do come find me. I come bearing gifts.


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Without Copyright, Hollywood Would Never Be Incented To... Make A Bunch Of Remakes?
from the nothing-new-under-the-sun dept
In fact, over the next 12 months, audiences can expect to see a new episode or version of "Planet of the Apes," "The Avengers," "Spider-Man," "Fright Night," "The Great Gatsby," "When Worlds Collide," "RoboCop," "Don't Be Afraid of the Dark," "The Thing," "Creature from the Black Lagoon," "The Raven," "Girl With the Dragon Tattoo," "Red Dawn" and "Footloose."But Hollywood is producing all these wonderful "new" and creative works, right? And remixing old works isn't creative at all?
Add those to recent updated versions of "Winnie the Pooh," "Clash of the Titans," "Karate Kid," "Alice in Wonderland," "Charlie and the Chocolate Factory," "War of the Worlds," "Arthur," "Charlotte's Web," "The Tourist" and "A Nightmare on Elm Street."
And deja vu happens when you turn the television on too.
This fall ABC are bringing back the 1970s series "Charlie's Angels," FOX is awakening "The Flintstones," MTV has its hands on "Teen Wolf," and we've already been slapped with Aaron Spelling's "90210" and "Melrose Place" on the CW, while NBC re-imagined "The Bionic Woman" and "Knight Rider."


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Oasis Dental Care, now part of BUPA Dental UK have an opportunity for a full time Associate Dentist to join the Aber Dental Practice in Flint.
Established, five surgery practice located just 15 miles from the City of Chester. The practice offers a modern working environment, benefits from digital facilities and a dedicated Dental Therapist. There is onsite parking and Flint Rail Station is located 0.5 miles from the practice.
There are 6250 UDAs available offering excellent NHS earnings plus Private potential.
At Oasis Dental Care our primary focus is on patient care and quality dentistry and as such we are recruiting Dentists that will share our values. Our mission is to make people smile!
There's actually a lot to love about Oasis!We're a fast growing business with an exciting future. So if you would like to play a part in our continued success then join us today. In return you will receive:
- Excellent Working facilities and the latest equipment
- Highest standards of clinical governance
- On-boarding and Induction process
- Excellent Clinical Structure and Support
- Oasis Indemnity that offers you full cover, bespoke to Oasis
- Continuous Professional Development
- Sponsored Education
- Career Mobility
So what's not to love... Is your heart in the right place?To apply or find out more, please send your CV and/or enquiries to [email protected]
If you or someone you know would be interested in working with a dynamic and expanding healthcare business we would love to hear from you!


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As I write this my computer monitor is framed by a dreary, cold, rainy view out the window behind it in our office at the Carolina Bed & Breakfast, our Asheville, NC Bed & Breakfast. So it is a pleasant task to review the pictures from our glorious Autumn outing on Thursday to Max Patch and remember the golden sunshine and bright display of foliage we enjoyed there.
Usually James and I choose to hike in the mountains on our day off but this time we decided to try a drive through the country to one of the better known "balds" in the Appalachian mountains. A bald is a large grassy area at the top of the ridges and mountains in southern Appalachia. Balds are below the timberline so are not related to
climate and it is a bit of a mystery how they came into being. The mostly commonly accepted explanation seems to be that the early settlers grazed their livestock on the tops of the mountains and ridges thus leaving the valleys free for farming. The trampling of the undergrowth along with the consumption of plants rendered these areas "bald". The resurgence of the forest on many of these balds in the past 50 years or so seems to bear this out.
Max Patch is one such bald. Located at 4600 feet it consists of a 350 acre clearing which affords 360 degree views of the surrounding Great Smokey Mountains. It seems that perhaps the name "Max Patch" comes from Mac's Patch as the land was originally farmed by Scottish immigrants. There are only a few published reports about Mac's Patch, one of which is about a Mrs. McMahon, an early Western North Carolina settler famous for her flower garden called "Granny Mac's Patch". Not definitive by any means but as close as we are probably going to get! In any case, we do know that the land on top of Max Patch Mountain was used as grazing land in the 1800's. Shortly after WWI, there was a landing strip there and the area was even home to a few airshows. It is now a part of Pisgah National Forest and the forestry department mows the grass in order to maintain the "bald". One tragic event took place on Max Patch in June of 2010. A young woman was hiking with her boyfriend who was taking her there to propose to her when she was struck by lightening. It is a cautionary reminder that our mountains can be cruel as well as beautiful.
On this particular October day, James and I decided to forgo our long hike in order to drive out into the mountains and enjoy some of the fall color. Here in Asheville things are just beginning to turn but guests had told us that the color was good up in the higher elevations. There are two ways to get to Max Patch: the quick way by the highway and the longer route on back roads. Since the point was to enjoy the valleys and mountains of our area James and I chose the slow route and drove on NC 63, also known as the Leicester Highway, past farms and small villages until we came to the gravel road which took us to the top of the mountain. Multiple switchbacks as we drove over Doggett
Mountain gave us breathtaking views of Asheville and Weaverville in the valley below and Grandfather Mountain behind them. This drive alone was worth trip. The gravel road up Max Patch Mountain is fairly well maintained but we met no one going up or down so we were surprised when we arrived at the parking lot to find a number of cars there. But as I mentioned, Max Patch consists of 350 acres so in spite of the cars we found ourselves alone for most of the afternoon.
There are two basic trails on Max Patch, a short mile long hike which takes you to the summit and a 2.4 mile hike which takes you around the perimeter. We began by hiking to the summit where we ran into just about the only people we saw the whole day. After enjoying the Sound-Of- Music-like view we walked a short distance away. The people disappeared and we talked about life and ideas while munching on Greenlife sandwiches in the warm sunlight. Afterwards we took the gentle hike around the perimeter before returning to our car and the drive home.
What's lovely about this drive and hike is that it is relatively unused by the tourists who come to see the foliage in the Asheville area in October. Even those who decide to drive to Max Patch will generally take I-40 and will arrive at the mountain without crossing Doggett Mountain. Max Patch and the drive to get there will certainly be one that we will recommend to our guests.
(n.b. For more pictures, visit our Facebook page)


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Thai Restaurant Favorites
- - Per Seat
What You Will Learn
Delicious Thai cuisine is all about balancing the complexity of sour, sweet, salty and bitter flavors into harmonious dishes. In this hands-on class you'll participate with others to learn how to combine aromatic herbs and spices with traditional ingredients and receive tips on how to best balance the unique flavors of Thailand for restaurant-quality, intensely flavorful dishes.
What To Expect:
Great cooking isn't about recipes—it's about techniques. In our classes you'll work together with other students in a fun, hands-on environment led by our professional chef instructors.
- Learn fundamental skills for a lifetime of great cooking
- Work side-by-side with other students to prepare each dish
- Interact with classmates and the instructor for a rich learning experience
- Classes are 2 to 2 1/2 hours and each student enjoys a generous taste of every dish
- Held in our professional teaching kitchens, each class is led by experienced chef instructors
- Students receive a 10% discount coupon to use the week after the class
Hazel Valdez


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Jered Sprecher says something about painting. As Sprecher speaks, just underneath my skin, the blood starts dancing. Pulsing its ruby hips along to a great horn section, a mildly panicked Bossa Nova heartbeat. This is circa 2001, and Jered is a year or two ahead of me at the college we were at, and he was thoughtful about painting. He thought about the surface, and he thought about abstraction. He thought about what painting meant to other people. On the other hand, my education was from the school of immaturity, famous for using the word vomit and bad jokes in poor taste. I learned from him, and began to look seriously at paintings as more than an image. Today, Jered's paintings are even stronger evidence of his thoughtfulness and clarity of vision.
Sprecher's new paintings combine abstraction with imagery. Some of the images are based on variations of a single photograph of three pigeons or doves. When painting, Sprecher worked on some of the pieces with a process of moving from top left to bottom right, the same method a dot matrix printer uses, and other paintings used a more intuitive method of layering paint. The human, the machine, the image, and the abstraction live together in this wor/k/ld.
Jered Sprecher has a solo show, Half Moon Maker, at Steven Zevitas Gallery in Boston. The show is up until May 10th, 2014. All photos courtesy of Steven Zevitas Gallery. Below you can find an interview with Jered about his newest paintings.


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Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01643278
Recruitment Status : Completed
First Posted : July 18, 2012
Last Update Posted : January 10, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Gastrointestinal Stromal Tumor Stage III Soft Tissue Sarcoma Stage IV Soft Tissue Sarcoma
|Drug: Dasatinib Biological: Ipilimumab Other: Laboratory Biomarker Analysis Other: Pharmacological Study
|Phase 1
I. To assess the safety and tolerability of treatment with ipilimumab in combination with dasatinib in subjects with gastrointestinal stromal tumor (GIST) and other advanced sarcomas.
I. Response rate (RR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, immune-related response criteria, and Choi criteria.
II. Progression free survival (PFS). III. Progression-free survival at 6 months (PFS6months). IV. Overall survival (OS). V. Immunological correlative studies.
OUTLINE: This is a dose-escalation study of dasatinib.
Patients receive dasatinib orally (PO) once daily (QD) for 7 days. Patients then receive dasatinib PO QD and ipilimumab intravenously (IV) once on weeks 1, 4, 7 and 10. Beginning on week 24, patients then receive dasatinib PO QD and ipilimumab IV once every 12 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up at 4 weeks and then every 3 months.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|29 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I Study of Dasatinib in Combination With Ipilimumab for Patients With Advanced Gastrointestinal Stromal Tumor and Other Sarcomas
|Study Start Date :
|July 2012
|Actual Primary Completion Date :
|June 2016
|Actual Study Completion Date :
|June 2016
Experimental: Treatment (dasatinib and ipilimumab)
Patients receive dasatinib PO QD for 7 days. Patients then receive dasatinib PO QD and ipilimumab IV once on weeks 1, 4, 7 and 10. Beginning on week 24, patients then receive dasatinib PO QD and ipilimumab IV once every 12 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.
Drug: Dasatinib
Given PO
Other Names:
Biological: Ipilimumab
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Other: Pharmacological Study
Correlative studies
- Maximum tolerated dose defined as the highest dose studied for which the observed incidence of dose-limiting toxicity is less than 33% according to the National Cancer Institute Common Toxicity Criteria [ Time Frame: Up to week 12 ]Frequencies of toxicities will be tabulated.
- OS as measured by RECIST 1.1, Choi and immune-related response criteria [ Time Frame: Up to 3 years ]Will be estimated using Kaplan-Meier methodology.
- PFS as measured by RECIST 1.1, Choi and immune-related response criteria [ Time Frame: From start of treatment to time of progression or death, whichever occurs first, assessed up to 3 years ]Will be estimated using Kaplan-Meier methodology.
- PFS at 6 months as measured by RECIST 1.1, Choi and immune-related response criteria [ Time Frame: 6 months ]Will be estimated using Kaplan-Meier methodology.
- RR as measured by RECIST 1.1, Choi and immune-related response criteria [ Time Frame: Up to 3 years ]Immune related response rate (complete response + partial response) and Choi criteria will be calculated along with a 95% confidence interval.
- Change in humoral and cellular immune response [ Time Frame: Baseline to up to 4 weeks after treatment ]Relationships between clinical response, lymphocyte phenotype, cytokines, and effect of dasatinib and ipilimumab on humoral and cellular immune responses will be evaluated. Summary statistics for peripheral blood biomarkers of immunoregulatory activity (T-cell subpopulation counts, cytokines, and corresponding changes [or % changes]) will be tabulated by study day/dose. Time courses of biomarker measures will be investigated graphically; further analysis may be performed to characterize relationships. Associations between changes and dasatinib exposure will be explored graphically.
- Change in tumor immunological markers in patients treated at the expansion cohort (as of May 2015 patients on expansion cohort will not undergo protocol biopsies) [ Time Frame: Baseline to up to week 6 ]Summary statistics for measures and changes from baseline of tumor-based markers including T-cell (cluster of differentiation [CD] 4, CD8, CD45, forkhead box P3), apoptosis markers, and indoleamine 2,3-dioxygenase 1/2 will be tabulated. Associations between biomarkers and efficacy measures will be analyzed in all response-evaluable subjects.
- Downstream molecular effects of therapy on tumor viability as measured by changes in KIT expression and secondary mutations in resistant tumor specimens [ Time Frame: Baseline to up to 4 weeks after treatment ]Changes will be correlated with tumor response by Fisher's exact test.
- Genotype (v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KIT] and platelet-derived growth factor receptor-alpha [PDGFR-a]) mutation status [ Time Frame: Baseline ]Associations of mutation status with response rate and PFS6months will be assessed using Fisher's exact test. Associations of mutation status with PFS and overall survival will be assessed using the log rank test.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- DOSE ESCALATION COHORT: subjects must have histologically or cytologically confirmed sarcoma that is metastatic or unresectable
- DOSE EXPANSION COHORT: subjects must have histologically or cytologically confirmed GIST that is metastatic or unresectable
- Patients must have measurable disease per RECIST 1.1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as >= 20 mm with conventional techniques or as >= 10 mm with spiral computed tomography (CT) scan, magnetic resonance imaging (MRI), or calipers by clinical exam
- DOSE ESCALATION COHORT: patients must have had at least one prior therapy
- DOSE EXPANSION COHORT: GIST patients must have had progression on or have been intolerant to imatinib and sunitinib
- Eastern Cooperative Oncology Group (ECOG) performance status =< 1 (Karnofsky >= 70%)
- Life expectancy of greater than 3 months
- Leukocytes >= 3 K/mcL
- Absolute neutrophil count >= 1.5 K/mcL
- Platelets >= 100 K/mcL
- Hemoglobin >= 8.0 g/dl
- Total bilirubin =< 1.5 x institutional upper limit of normal; note: patients with hyperbilirubinemia clinically consistent with an inherited disorder of bilirubin metabolism (e.g., Gilbert syndrome) will be eligible at the discretion of the treating physician and/or the principal investigator
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limit of normal
- Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of dasatinib administration
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Patients who have had chemotherapy (non-tyrosine kinase inhibitor [TKI]) or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
- Patients with a history of prior treatment with ipilimumab or dasatinib
- Patients who are receiving any other investigational agents
- Patients with known brain metastases are excluded from this clinical trial
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib and ipilimumab
- Patients who require concurrent treatment with any medications or substances that are potent inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
- Patients who require concurrent treatment with any medications or substances that have significant proarrhythmic potential are ineligible
- Patients with any condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation, prior surgical procedures affecting absorption, or active peptic ulcer disease) that impairs their ability to swallow and retain dasatinib tablets are excluded
Patients may not have any clinically significant cardiovascular disease including the following:
- Myocardial infarction or ventricular tachyarrhythmia within 6 months
- Prolonged corrected QT interval (QTc) > 480 msec
- Ejection fraction less than 50%
- Major conduction abnormality (unless a cardiac pacemaker is present)
- Uncontrolled intercurrent illness including, but not limited to, the following: ongoing or active infection; history of significant bleeding disorder, including congenital (von Willebrand's disease) or acquired (anti-factor VIII antibodies) disorders; large pleural effusions; or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with dasatinib
- Subjects may not have known human immunodeficiency virus (HIV), active hepatitis A, or hepatitis B or C infection
- Subjects with any active autoimmune disease or a documented history of autoimmune disease or history of syndrome that required systemic steroids or immunosuppressive medications including but not limited to inflammatory bowel disease, rheumatoid arthritis, autoimmune thyroiditis, autoimmune hepatitis, systemic sclerosis (scleroderma and variants), systemic lupus erythematosus, autoimmune vasculitis, autoimmune neuropathies (e.g. Guillain-Barre syndrome), and multiple sclerosis; patients with vitiligo, asthma and diabetes are NOT excluded; final determination can be left to the discretion of the principal investigator
- Subjects may not have ongoing chronic diarrhea
- Subjects may not have had prior organ allograft or allogeneic bone marrow transplantation
- Subjects may not have any major surgery within 4 weeks
- Subjects may not have known current drug or alcohol abuse
- Subjects may not have an underlying medical condition that in the opinion of the investigator could adversely affect the ability of the subject to comply with or tolerate study procedures and/or study therapy, or confound the ability to interpret the tolerability of combined administration of dasatinib and ipilimumab in treated subjects
- Subjects may not have other active malignancies other than indolent malignancies not requiring active therapy which the investigator determines are unlikely to interfere with treatment and safety analysis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01643278
|United States, New York
|Memorial Sloan-Kettering Cancer Center
|New York, New York, United States, 10065
|Principal Investigator:
|Sandra D'Angelo
|Memorial Sloan Kettering Cancer Center
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01643278 History of Changes
|Other Study ID Numbers:
NCI-2012-01165 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
9172 ( Other Identifier: Memorial Sloan-Kettering Cancer Center )
9172 ( Other Identifier: CTEP )
P30CA008748 ( U.S. NIH Grant/Contract )
U01CA069856 ( U.S. NIH Grant/Contract )
|First Posted:
|July 18, 2012 Key Record Dates
|Last Update Posted:
|January 10, 2017
|Last Verified:
|January 2017
Additional relevant MeSH terms:
Gastrointestinal Stromal Tumors
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms, Connective Tissue
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Antibodies, Monoclonal
Immunologic Factors
Physiological Effects of Drugs
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


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Hot Stove 2010: Options for a SP
December 4, 2009 Leave a comment
I started doing these summaries as one post, and it just got too darn long. I just ad to throw away my shortstop post today. Anyway, on we go to starting pitching.
The Sox rotation is young (apart from Tim Wakefield) and strong, but lacks veteran depth. Behind a budding ace in Jon Lester and a very solid Josh Beckett, we've got (at worst) a middle-of-the-rotation filler in Daisuke Matsuzaka and some young talent. The Sox could easily go their typically conservative route, or they can trade away some of those juicy prospects for an upper-tier pitcher:


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Product Details
Throttle Cable Bracket by Big End Performance®. This product is made of high-quality materials to serve you for years to come. Designed using state-of-the-art technology and with customers in mind. It will meet your needs and deliver great quality at an affordable cost.
- High quality at an affordable price
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Big End Performance® is a great source for a huge selection of top performance parts that are second to none in quality and durability. The company stays ready to provide the customers with the right solution that will satisfy their automotive needs. Among the products Big End Performance offers are engine parts, ignition components, gauges, fasteners, automotive tools and much more. All products provided by the brand are manufactured from top-grade materials utilizing the latest technologies to ensure exceptional wear resistance and long-lasting service life.


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Engineering Library Reserve
- Information for Faculty
- General Engineering Library Reserves information: submitting reserve lists and materials
- Information for Students
- Engineering Library Reserve information about reserve policies and how to use the reserve collection
- Reserve Desk hours
- The Reserve Desk is open the same hours the Circulation Desk is open. These desks close ten minutes before the library closes. If you wish to check out materials, please arrive at the desk at least fifteen minutes before the library closes.


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Ancient Near Eastern Art
An extraordinary selection of silver-gilt ceremonial vessels, created in Iran during the Sasanian Empire (ca. 224–651), are on view in the Freer's west corridor. The vessels' elegant shapes and rich imagery epitomize the cosmopolitan style of this period. Also on display is the so-called Gold Treasure, a group of Byzantine works of art attributable to sixth- and seventh-century Constantinople but discovered in Egypt.


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Walter Joseph McReady, 73, of Lake Ariel, formerly of Commack, N.Y., passed away unexpectedly at his in Lake Ariel home on March 16, 2013.
Born on July 21, 1939, he was a son of the late Walter P. and Johanna (Fischer) McReady. He grew up on Guernsey Street in Brooklyn, N.Y.
Walter was a veteran of the U.S. Army, where he proudly served his country in Operation Desert Storm. He retired from the New York City Police Department, protecting the public, at the 109 Precinct in Flushing, N.Y. He was employed by New York Telephone Co. for many years before becoming a confidential investigator for the Long Island Developmental Center. He ended his working career as security for Elwood Middle School, where he loved interacting with the students and faculty.
Walter did not ease into retirement. He enjoyed working with wood, and shared his numerous creations with his friends and family. He recently started volunteering with the Make a Wish Foundation and would travel with his family at every opportunity.
He will always and forever be remembered for his love of Ireland, kindness, thoughtfulness and selflessness, but mostly for his sense of humor and his undying love of his children and grandchildren.
He is survived by his children: his daughters, Mary Jon Olney-Zoeller and her husband, Peter, of Melbourne, Fla., and JoAnn Ramsdale and her husband, Chris, of East Stroudsburg; and his son, Walter P. and his wife, Barb, of Sharpsburg, Ga.; and his grandchildren: Kevin, Christopher, Kelly, Patrick, Walter J., Kathleen, PJ, Heather and his great-grandson, Joseph: his sister, Patricia; his brother, Edward; and numerous nieces, nephews, cousins and second cousins. He also leaves behind a large circle of loving and caring friends, who he also considered family.
There will be a viewing from 2 to 4 p.m. and 6 to 8:30 p.m. Thursday, March 21, at William H. Clark Funeral Home, 1003 Main St., Stroudsburg.
A Mass of Christian Burial will be celebrated at 10 a.m. Friday, March 22, at St. Mary's Roman Catholic Church, 300 St. Mary Church Road, Lake Ariel (village of Ledgedale), with the Rev. Michael Finn as celebrant. Burial will follow at St. Mary's Church Cemetery.
In lieu of flowers, the family asks that memorial donations be made to any of the following organizations that were close to Walter's heart: Make-A-Wish Foundation, American Heart Association; or NYPD Emerald Society.
William H. Clark Funeral Home
1003 Main St., Stroudsburg
Walter Joseph McReady
Walter Joseph McReady, 73, of Lake Ariel, formerly of Commack, N.Y., passed away unexpectedly at his in Lake Ariel home on March 16, 2013.


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When Ignat Solzhenitsyn's career began a couple decades ago, the piano was his primary focus. In short order, the podium attracted his attention, and he has enjoyed significant success as a conductor.
Over the weekend, this son of the Nobel Prize-winning Russian writer and dissident Aleksandr Solzhenitsyn led the Baltimore Symphony Orchestra in stirring performances of Mozart's Requiem and Arvo Part's "Tabula Rasa."
The Estonian-born Part is perhaps best described as a musical mystic. Like the minimalists, he often relies on basic chords or reiterative melodic phrases, but he invariably adds something spiritual to the mix.
He's a sound-poet who creates transfixing experiences where time seems suspended, allowing the ear, intellect and heart to converge on a single path.
"Tabula Rasa," from 1977, is scored for two solo violins, prepared piano and strings. There is tremendous tension in the first movement, as much from the frequent silences as from the final, emotional surge toward a long-held A minor chord.
The much slower second movement, which revolves around a simple theme that gently rocks back and forth, seems to float between two worlds until finally slipping downward in tone coloring through the cello and bass sections and out of ear shot.
It casts a poignant spell -- on Saturday night at Meyerhoff Hall, that spell was strong enough to silence most of the coughing in the audience.
Solzhenitsyn drew a beautifully shaded account of "Tabula Rasa" from the players.
Violinists Madeline Adkins and Qing Li delivered their solos with considerable nuance; the string ensemble likewise did sensitive work. Lura Johnson was the fine pianist (the instrument was modified to sound like bells, both ominous and comforting).
The conductor approached the Mozart Requiem in an intriguing, double-edged manner.
His fleet tempos reflected today's interest in historically informed performance practice, but his tendency toward emotional phrasing and his interest in huge fortissimos -- made all the easier by having the large scale Baltimore Choral Arts Society on hand -- suggested a more romantic style from years past.
I would have gladly welcomed subtler touches in a few places (notably the Agnus Dei), just as I would have been very happy with slower pacing in others (the Lacrimosa, for example).
But the performance as a whole grabbed hold. In a way, it seemed as if Solzhenitsyn was determined to make Mozart's Requiem sound every inch a precursor to Verdi's.
The chorus was in great form, articulating cleanly even at breakneck speeds and maintaining a firm, full tone in each section of the ensemble. The men charged into the Confutatis with remarkable ferocity that made the women's subsequent, soft plea of "Voca me" all the more telling.
There was an excellent quartet of guest artists -- soprano Susanna Phillips (particularly sweet in the Lux Aeterna); mezzo Marietta Simpson (vocally a little pallid, but still eloquent); tenor Norman Reinhardt and bass Robert Gleadow (both sang with considerable expressive impact throughout).


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by Tom Utescher
After a relatively routine win in Tuesday's quarterfinal round in the NCAA Women's Summer League playoffs, the top-seeded Lime Green team found its undefeated record in jeopardy late in Thursday's semifinal contest against the Cardinal Red club.
Fifth-seeded Cardinal overcame a double-digit deficit in the second half to go up by a point with under four minutes to go, but two-time defending champion Lime rallied and then held on for a 65-62 victory, earning a spot in this week's best-of-three final series. Lime Green, which includes Mount St. Joe grad Elle Hagedorn and is coached by her father, Ted, will square off in this week's best-of-three final series against the second seed, Team Black, which knocked off number three Hunter Green in the other semifinal on Thursday, 72-58.
In the quarterfinals, Black eliminated the Philadelphia University entry, Team Orange (the seventh seed), 69-51. Earlier on Tuesday evening, Lime Green won its own playoff opener, 72-51, over number eight Purple, as guard Katie Kuester accumulated a game-high 26 points.
An opening lay-up by Devon Kane and seven straight points by her former Academy of Notre Dame teammate, Kuester, launched Lime Green to a 9-0 lead, but although they remained in control the rest of the way, this wasn't your typical first seed/last seed blow-out.
Purple regained its poise and closed up the score to 9-5, then Lime's Katie O'Reilly recorded a 15-footer and a three-point field goal back-to- back. Lindsay Fluehr tacked on a lay-up and free throw to make it 17-5.
That pattern repeated itself, with Purple shaving some points off of its deficit, only to have Lime Green rebound with a little offensive burst, often spearheaded by Kuester. She had 21 points at halftime, when the league leaders were up 37-28.
Lime's Liz Sharlow canned seven of her nine total points after the intermission, and her club quickly pushed its lead into double figures for good. Approaching the ten-minute mark, the score was 55-37, and at its widest the gap reached 24 points.
Two of Lime's regular big guns, Dana Mitchell and Meg Pearson, scored 11 points between them, but there was more than enough point production from Kuester, O'Reilly (10), Sharlow, and Kane (eight) to get the job done. Forwards Devin Shea and Addie Micir recorded 14 and 13 points, respectively, for the Purple, who got a dozen points from shooting guard Trish Watson.
The Team Orange hoopsters from Philly U. had a lot of players on hand for their quarterfinal game, but they were missing senior Kristen Blye, a team co-captain and one of the squad's most experienced post players. Even with one of their own inside starters missing, Team Black had a size and rebounding advantage.
This, along with strong guard play from former Spring Ford High School star Ashley Wood (now at Kutztown), among others, allowed the second seed to control the tempo of the game after about the first 10 minutes. Orange hung in for the first quarter of the contest, though. After Black burst out to a 13-4 advantage, Orange sophomore Tori Arnao (Archbishop Wood) scored eight points in a 10-2 run that tightened the score to 15-14.
After that, though, Orange was held without a field goal for almost four minutes as Black took control with an 11-1 counterattack. Following a halftime interlude with the scoreboard resting at 40-25, Orange struck first when play resumed, but the next 16 straight points belonged to the Black.
Although GA grad Monica Schacker rang up all of her seven points in the second half, Team Black was able to cruise to the finish line behind 21 points from Kerry Kinek, a forward just entering Lehigh University. Wood hit 13 points for the winners and fellow guard Jasmine Elum added 12, while the Orange ended up with 14 points from Arnao and eight from Najah Jacobs, a guard in her second year out of Central High School.
Whenever the Lime Green ballclub takes the court, the opposition tries to contain Kuester, and in Thursday's semifinal round Cardinal Red did a good job in that regard. But while Kuester was held to a relatively modest seven-point output, Mitchell reasserted herself on offense, scoring inside and out for a game-high 27 points (including a 10/11 effort at the free throw line).
Mitchell's total was almost matched by diminutive but dynamic Cardinal Red guard Ashley Morris, who struck for 25 points. Morris played for Central High and Temple University, and now is back at Central heading the girls basketball program.
In the first half, Lime Green built a lead that approached double-digits at one stage, and Cardinal Red trailed by half-a-dozen points at halftime, 31-25. The top seed forged ahead by as many as a dozen points in the middle of the second stanza, and again Cardinal came back, this briefly enjoying the advantage at 51-50. Lime Green regained the lead and went up by a couple baskets before Morris made a "three" just before the buzzer, setting the final margin at three points.
Pearson contributed nine points to the winning cause, while Cardinal Red received 12 points from Emily Homan and six from Kelly Loughney, both of whom played on Hagedorn's team in 2011.
In the other semifinal, Kinek once again led the victorious Black team with 18 points, while a game-high 19 was deposited by Hunter Green guard Ciara Andrews, just out of Cheltenham High School and headed to St. Joseph's University.


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E-40 (Feat. Stresmatic) - The Weed Man
E-40's new music video "The Weed Man Feat. Stresmatic" from the upcoming album Revenue Retrievin' Day Shift. Both albums Revenue Retrievin' Day Shift and Night shift in Stores March 30. Make sure to stop by iTunes and pre view all 42 songs ( bit.ly/9x40EZ )
Please click the "Report" button below if the video on this page is not working properly.
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Writing Documentation
Writing Docbook Documentation for the PKP
This document is currently extremely incomplete, and undergoing revisions as I switch from DocBook4.5 to 5.0.
Creating a Docbook XML sourcefile is mainly a matter of identifying what kind of document you are working on, what kinds of tags you should be using to describe your document. This meta-document details the steps I use to create book- and article-level source documentation for the Public Knowledge Project. It will also describe the steps I take to transform XML source files to HTML and PDF.
Writings, books on DocBook
- DocBook v5.0: The Definitive Guide
- DocBook XSL: The Complete Guide
- Dave Pawson's DocBook site, may be slightly out-of-date
XML Editors
Writing an Article
First, choose whether you are writing a book or an article. This identifies the root element you'll start with: <book> or
. For the rest of this document, we'll assume we're writing an article.
At bare minimum, your source file will look like so:
<?xml version="1.0" encoding="UTF-8"?>
 <info> <title>Importing and Exporting Data with OJS</title> <author> <orgname>The Public Knowledge Project</orgname> <address> <city>Burnaby</city> <street>8888 University Drive</street> <postcode>V5A 1S6</postcode> <country>Canada</country> </address> <email>email@example.com</email> </author> </info> <sect1 xml:id="preface"><info><title>Preface</title></info> <para>...</para> </sect1>

Writing a Book
Info will come as I convert the OxS in an Hour docs as well as the Technical Reference.
Common Elements
You can find a list of all elements for DocBook 5.0 here.
Inline Elements
- Use <filename>/plugins/importExport/native/native.dtd</filename> when you are referring to file names and locations.
- Use <command>php importExport.php</command> when you reference commands.
- Use <userinput>User Home</userinput> for referencing ... user ... input.
<para>To import a file, you can use <userinput><embed></userinput> to place a file directly within your XML document, or use <userinput><href></userinput> to link to one.</para>
- Use <![CDATA[[
all this text up in here
]]> for tags that should be ignored. This example would tell the parser to ignore those
tags. (Let me know if you come up with a clever way to ignore <![CDATA[]]> itself.)
- Use <element xl:href="http://pkp.sfu.ca">Public Knowledge Project</element> to hyperlink to an external page. "element" can be any inline element. You can also use "link" as a generic element I think.
- Use <element linkend="sectionId">link text</element> for linking within the document itself. "element" can be any inline element. You can also use "link" as a generic element I think.
Block Elements
- Use <programlisting>/multiple lines of code/</programlisting> for large, multiline code blocks.
- Use <tip><para>this is a tip</para></tip> for notes, suggestions, tips, etc.


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Van Halen's New Song 'Stay Frosty' Debuts on 'CSI'
The slow leak of new songs from Van Halen's 'A Different Kind of Truth' continued on Wednesday night's episode of 'CSI' on CBS. 'Stay Frosty' was one of two songs ('Tattoo' was the other) included during a scene in which Marg Helgenberger and Ted Danson's characters hid out in a strip club.
For the most part 'Stay Frosty' was background music, but the track did get a few seconds in the forefront as the two character's entered the alley-side men's club. Fans can get a better idea of what the full song will sound like in the official preview video, also pasted below.
'Stay Frosty' is built similar to the 1978 hit 'Ice Cream Man,' with Eddie Van Halen picking on an acoustic early as David Lee Roth works his way through the lyrics. This intro lasts a bit longer, and there isn't nearly as much innuendo before the rest of the band starts playing and Eddie switches to electric. At that point the preview ends, but the 'CSI' clip picks up where the preview wraps up.
In honor of Eddie Van Halen's birthday today (Jan. 26), we're taking a tour through every one of the band's albums and giving you the chance to vote for the best song from each one in our Van Halen Album by Album Readers' Poll.


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Here's the latest word on surviving an angry marriage: have a fight. It could save your life.
A new study out of the University of Michigan has produced a startling finding. Couples that suppress their anger when they have been unfairly attacked, either by the spouse or someone else, are twice as likely to die earlier than persons who admit they are angry and deal with their problem.
The study adds to a growing body of evidence that suppressing anger can be deadly because it drives up blood pressure and contributes to anxiety and depression, but this study takes it a bit further. If one spouse suppresses his or her anger, that individual is likely to die earlier. But if both spouses suppress their anger, the odds go through the roof.
"What intrigued me was the percent of double deaths, where they both died," research scientist Ernest Harburg said in an interview.
Harburg and his colleagues have been studying several hundred families in the Michigan village of Tecumseh since 1971. For the latest study, published in the January issue of the Journal of Family Communication, the researchers divided 166 couples into four groups, one of which consisted of couples where both spouses described themselves years ago as unwilling to show their anger.
Three of the groups consisted of couples where one or the other might suppress anger, but not both. Both spouses have died in only 6 percent of those couples.
But in the fourth group, where both spouses suppress their anger, 23 percent of both the husbands and the wives have died.
That, Harburg said, is extraordinary because there have not been a lot of deaths among the study participants, so 23 percent of both spouses is a very large figure.
Harburg, who at 81 is one of the nation's leading experts on anger, said Americans are reluctant to show their anger, and that makes the anger less likely to go away.
"Anger is interesting in the American culture," he said. "You're not supposed to express your anger. That's the norm, and we have to ease out of that norm and say it's healthy to express your anger and move on to solve the problem."
Of course, he doesn't mean that if a husband and wife get into a dispute they should declare war on each other. The trick is to make sure the other person knows you're angry, and then try to "achieve consensus."
"First, you have to listen," he said. "You have to understand the other person's point of view. You have to understand your own point of view. And then you have to use your imagination to resolve the problem. Some people are good at it, but most people aren't."
In those who aren't, their anger may fester, which can gradually gnaw away at the body's survival system.
Tecumseh, the setting for the study, is a small, rural community south of Ann Arbor, Mich., and it is not typical of the country's overall population. As the study notes, it is "ethnically homogeneous [Anglo-Saxon], with little socioeconomic diversity or conflict," and the participants were "born and raised prior to the 1960-70 sexual revolution."
It's difficult to study anger, Harburg said, because the word is so vague. There is no overall scientific definition of the word, he added, because each discipline has its own definition, and "they don't talk to each other."
Early in his career, Harburg determined that one element was essential for anger to exist. There has to be a sense of unfairness, a false accusation for example and there has to be a sense of personal loss, like respect or self-esteem.
But by any definition, anger that is allowed to fester will "reinforce the morbid conditions in your body, and after 50 everybody's got at least one, like elevated blood pressure, bronchial difficulties, and so forth," Harburg said. "The combination will lead to earlier mortality."
The study reaches a wide range of conclusions, all of which are labeled preliminary because the study is ongoing and the numbers are still small because most of the participants are still alive. Here are a few of the findings:
Incidentally, there have been very few divorces among the older couples of Tecumseh.
"They were into the old, classic marital style of staying together," Harburg mused.
Harburg admits to having a powerful temper as a young man. Over the years he has learned to deal with his anger, "but my wife and four sons don't believe it."
One of the things that comes with old age, he added, is a little mellowing. But his research suggests that if you want to reach that mellow stage, you shouldn't let the anger burn inside you.
Lee Dye is a former science writer for the Los Angeles Times. He now lives in Juneau, Alaska.


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By GEORGE ING
For the Hood River News
May 11
You can grow good tomatoes but don't plant them too soon!
Until I moved to Hood River, I had lived in cooler areas where it was difficult to grow tomatoes. Years ago, garden tomatoes were grown from seed. There have been dramatic changes, so much so that we do not really grow the plant; much of that is taken care of before we get it. We nurture it and harvest its production.
Nowadays almost all tomatoes are purchased by home gardeners as plants. Some may be large with either blooms or even small tomatoes attached. That means that if you purchase such a plant, you will be able to mature fruit even in a cooler area.
Secondly, the world of variety development has given us early season, quick-maturing tomatoes. We can thank the Oregon State University breeders for varieties such as Santiam, Siletz and Legend. All are dark green in color with thick foliage and are relatively small plants when mature thus can fit in a small place. Fruits are medium to large, are often russeted or scarred and may even have some cracks. But, boy are they good to eat! Sometimes the first ones ripen by July 1. As small bushes they do not have numerous fruits but the fruits ripen well into the summer.
For later varieties, it seems those with "Better, Beef or Boy" in their names do well. Plants grow large, demand support and can produce many fruits. Fruits mature and taste better if they have only minimum irrigation. While elongated or pear-shaped red or yellow varieties are interesting, I do not find their flavor to be as good.
When fall comes and green tomatoes remain, they can be harvested, vines and all, hung in a cool place and will usually ripen. I am thus able to eat tomatoes for lunch most years past mid-October.
An interesting aspect of gardening is that there is a "time." Thus, peas do best if planted in late February. Conversely I plant corn about May 10 because earlier the soil is not warm enough and seeds may not emerge. Tomatoes are a warm weather crop and should not be planted, in my opinion, before May 1. And you should be ready to cover tomatoes at night until May 15. We keep a batch of old 4-gallon buckets handy for such.
Let the garden suppliers keep tomato plants until things are right. You are ensured good growth and delicious tomatoes.
Orchardist and general green thumb George Ing takes time from his growing interests to write "Side Roads" for the Hood River News once each month.
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The Dressed Up by Veromia DU227 is part of our plus size Mother of the Bride collection.
Please call us to check availability as some sizes/styles may have been sold.
Sizes in Store: 22 – 28
Sample Location: Newport
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