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|2013-04-07, 16:32
|Link #281
He Without a Title
Join Date: Feb 2008
Location: The land of tempura
That was a great way to kick start the show. Lots of flashy scenes and great pacing. The mecha itself felt great as well and the world seems quite interesting. I was particularly interested in that conversation between the computer and Ledo at the start and how it conveys something rather important about the great empire. It looks like soldiers (at least) only get recognized as citizens after a minimum amount of time spent in service. That's a rather interesting tidbit that I hope will serve as a basis for comparison with this waterworld Ledo finds himself in.
On the other hand I wouldn't mind seeing what Gen would do with that concept of earned citizenship since that seems to lend itself to the type of stories he's known for (the ones that nicknamed him butcher )
|2013-04-07, 16:51
|Link #282
Senior Member
Join Date: Mar 2007
Anyways, I got a huge Ender's Game vibe from the first half. The whole battle felt like Ender's fleet fighting the buggers, especially the Little Doctor like device they were using.
|2013-04-07, 17:05
|Link #283
Osana-Najimi Shipper
Join Date: Dec 2005
Location: Mt. Ordeals
So he time travelled back to Earth before humanity set out for the stars? Colour me disappointed, since I loved the epic space battle in the beginning, and I doubt we'll ever get back to it. Now we're onto land and sea battles, which doesn't tickle my fancy as much as space battles do.
|2013-04-07, 17:10
|Link #284
Senior Member
Join Date: Mar 2007
|2013-04-07, 17:10
|Link #285
Senior Member
Join Date: Oct 2008
Location: stuck between galaxies
I'm really glad there's finally a show which lives up to expectations, and then some. I suppose it's pretty much redundant now to talk about how great everything is about this first episode.
I hope Gen and co can keep up with this so that by the end of it I'll have one more series to add to my all time favourites!
But yeah I'd love to see more about life (or the lack thereof?) in the Alliance. Maybe there'll be flashbacks in future eps about Red's life growing up as a soldier.
BTW does it look like the soldiers in the Alliance are clones or at least artifically grown, judging by the same hair colour? Maybe to do with coping with heavy losses fighting the war? That could explain the "right to reproduce"...
|2013-04-07, 17:20
|Link #287
Kana Hanazawa ♥
Join Date: Jun 2007
Location: France
Age: 32
That was even better than I expected. Wonderful animation, gorgeous scenery and battles, and bright color palette. The soundtrack isn't bad either.
Both settings (futuristic space colony Avalon and what I assume is a post apocalyptic Earth) were very interesting. I'm dying to find out more about the universe of Gargantia. I'm curious to see how they will tie everything in exactly. The previews made it seem like this would be a rather light-hearted show compared to Urobuchi's usual works, but the prologue indicates otherwise. We will definitely hear of those mysterious aliens again, and I wouldn't be surprised if they took the fight all the way to Earth. This could get dark pretty fast.
|2013-04-07, 17:27
|Link #288
Anime-Only Viewer
Graphic Designer
Join Date: Apr 2006
Location: USA
Definitely a very interesting start to the series. I hope that things will continue to develop well. I'm not sure yet if the story will be about the fights with the aliens or living on an underdeveloped earth. One of the better first episodes this season.
|2013-04-07, 17:29
|Link #289
Senior Member
Join Date: Mar 2007
|2013-04-07, 17:35
|Link #290
Swayin' to the beat
Join Date: Dec 2006
Nice start to the series. It looks like they blew their money shot this episode, and boy did they with that space battle. Now, I look forward to a fish out of water scenario and go from there. I was going "NOOOOOOOOO!!" at the end of the episode, and am ready for the next one.
|2013-04-07, 17:46
|Link #292
Kana Hanazawa ♥
Join Date: Jun 2007
Location: France
Age: 32
|2013-04-07, 17:53
|Link #293
Beyond the Fringe
Join Date: Jun 2011
Knowing zippo about this new series until I watched it, I admit I was a little bored by the first half of the show, not being a great fan of mecha battles. However, as soon as the second half started, my interest certainly perked up. Amy in her very bright costume running through the corridors of what looked to be an old an dilapidated ship started to make things look much more interesting for me. The show suddenly switched from a mecha battle anime to, well, what???
My only disappointment was that, with all that obsolete fire power aimed at him, the MC didn't get blown from here to kingdom come. I wonder what his buddy would have done without him.
|2013-04-07, 18:40
|Link #294
Join Date: Aug 2004
Age: 32
Pretty sure there was no time travel. Earth is just a backwater now, which makes sense since the Human Alliance or whatever seems to have lost track of it somewhere along the way.
I very much doubt we've seen the end of the space bugs or the Human Alliance, and I'm expecting to see inside Avalon at some point, although I'm not sure how we're going to get from here to there.
|2013-04-07, 19:24
|Link #296
Join Date: Oct 2006
HAH first show of the season that genuinely gets my interest up and I find out Gen wrote it...Why am I not surprised? Here's to hoping they can do more with the setting then Psycho did. Like others said I wanna hear more about society on that world ship/colony he comes from.
|action, harem, mecha, military, post-apocalyptic, sci-fi, urobuchi
|Thread Tools


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You are currently browsing the tag archive for the 'The Torontoist' tag.
There are some people who embrace a lack of technology – when we are overwhelmed with our phones, ipods, laptops and gadgets, some people just chuck it all. A new game cafe with a great name, Snakes and Lattes (get the play on words with that childhood board game we all played) is opening up in Toronto. Owner Ben Castanie and his partner and girlfriend Aurelia Peynet are opening up a cafe equipped with 1,500 plus board games. The cafe is the first of its kind in Toronto, although these types of cafes are popular overseas.
For a $5 fee, a customer receives unlimited use of the board game collection during their visit at the cafe, which also serves coffee products and snacks and is awaiting a liquor license. We've had our fair share of rounds of Pictionary and Taboo a'la alcohol and it can be quite fun, should be interesting to see how their business works out. They offer to hook groups of people up for games where groups or teams are required. Who knows, they could be onto game dating.
In any event it should be interesting to see how long customers can last being 'unplugged'. Not a WiFi hotspot to be found evidently.
For the entire article that ran in the Torontoist check here.

subset: commoncrawl


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"I can deal with the discomfort. But when it started to affect my pitches, I wasn't able to finish them and able to get the ball down."
"I've been fortunate. [My elbow] feels good. I've got all this newfound range of motion. We'll see what I can do with it."


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by Constance Garcia-Barrio
In April I threw open the windows of my house and took a swipe at winter's dirt. As I carried cleaning rags and a bucket of soapy water from room to room, I decided that year's spring cleaning should include more than the walls and floors. I wanted to rid myself of a certain smudge on my spirit: I hold on to grudges as if they were money.
I told a friend about two emails I received from someone I hadn't heard from in six years. This person had done me grievous hurts in the past.
"What did his email say?" my friend asked.
"I don't know," I said. "I deleted his messages unread."
"He might have been apologizing."
My friend gave me a long look, and then told me the story of the young monk, the older one and the haughty woman. When the woman asked for help to cross a creek, the older monk carried her to the other side on his back. The woman walked off without a word. Hours later, the young monk asked the older one why the woman's ingratitude didn't anger him. The older monk said, "Why are you still carrying her? I put her down a long time ago."
The story gave me food for thought, as did a course I'm taking at the Philadelphia Shambhala Meditation Center. Called "A year to live," the course invites participants to lead our lives as if this year — or day, or hour — was to be our last. With whom and in what state of mind would we want to meet death?
Did I want to drag this grudge into eternity?
An acquaintance summed up the effect of grudges in starker terms: "It's like drinking poison and waiting for the other person to die," she said.
Yet, I stayed on this grudge like a setting hen, keeping it nice and warm. A good friend, local psychotherapist Susan K. Martel, Ed.M., explained why. "Our instinct is to protect ourselves, so holding a grudge is like using a shield against the hurt caused by the person or situation," she said. "The problem is that the grudge takes up space within us that we could use for something healthier and more productive."
Susan also pointed out that revisiting hurtful words and incidents could dig me in deeper. "A grudge can become self-reinforcing, almost a conditioned response," she said. "That leaves little room to be thoughtful."
Simmering resentment can grip not just the psyche but the body, Susan said. "For example, some people feel a tightening in the chest or gut when they think of the other person," she said. "The holding becomes almost second nature."
Maybe forgiving would be the best revenge, but how could I start?
The first step, though simple, challenged me. Susan suggested that I sit, breathe deeply, and notice what parts of my body I tightened when the person came to mind. "Rather than just holding the grudge, explore it," she said. "If you can, relax around it. Consider the stress involved in holding a grudge. Have compassion for yourself."
Susan explained that softening toward the grudge wouldn't mean forgetting what happened, condoning it or turning the other cheek. "Softening will let you take a healthier stance," she said.
I took Susan's words to heart, but veteran grudger that I am, I needed a bit more to let go. Prayer helped, but I also searched for a ritual that would give gently lead me forward.
Two weeks ago, I went to the ocean. I fed the seagulls bread to allow myself time to slow down, to breathe in the salt scent and watch the crashing waves that, as Ross McDonald wrote, rolled in "like measured installments of eternity." I removed my shoes and walked to where the water just covered my feet. I made an offering and asked for release from grudges in general, especially this one that had sunk in its talons. I returned home lighter, yet I knew that this short visit to the sea amounted to a pre-soak cycle. I had to do more.
I returned to the ocean the following week and repeated what I'd done the earlier time, except this time I sat on the beach and waited, my eyes closed much of the time, asking for healing. When I left a good hour later, the cleansing felt more complete.
If I were to receive an email from this person today, I would at least read it. I would let my intuition lead me about whether to respond, and if so, how.
At least I've made a start in this other spring cleaning. I can feel something lighter rising in me from the detritus of seasons past.
Constance Garcia-Barrio, a freelance journalist and Mt. Airy resident, teaches at Community College of Philadelphia. She received an award for a magazine feature story from the National Association of Black Journalists. Her articles have appeared in The Philadelphia Inquirer, Christian Science Monitor and several literary magazines in addition to the Local. You can contact her at firstname.lastname@example.com.


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On 11/16/16, Sleep Country Canada Holdings Inc (TSX: ZZZ.TO) will trade ex-dividend, for its quarterly dividend of $0.15, payable on 11/28/16. As a percentage of ZZZ's recent stock price of $27.77, this dividend works out to approximately 0.54%, so look for shares of Sleep Country Canada Holdings Inc to trade 0.54% lower — all else being equal — when ZZZ shares open for trading on 11/16/16.Below is a dividend history chart for ZZZ, showing historical dividends prior to the most recent $0.15 declared by Sleep Country Canada Holdings Inc: In general, dividends are not always predictable; but looking at the history above can help in judging whether the most recent dividend from ZZZ is likely to continue, and whether the current estimated yield of 2.16% on annualized basis is a reasonable expectation of annual yield going forward. The chart below shows the one year performance of ZZZ shares: Looking at the chart above, ZZZ's low point in its 52 week range is $15.12 per share, with $34.15 as the 52 week high point — that compares with a last trade of $27.75. In Monday trading, Sleep Country Canada Holdings Inc shares are currently up about 0.1% on the day.
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Real Madrid plans to open a $1 billion soccer-centric theme park on a United Arab Emirates man-made island in January 2015 that celebrates the history, triumphs and hubris of the richest football club in the world.
PHOTOS: Real Madrid Resort Island in the Middle East
The 100-acre Real Madrid Resort Island will feature a roller coaster that extends out over the water, a SeaWorld-style dolphin show and a hologram soccer movie inside a climate-controlled theme park. A promotional video for the proposed UAE resort uses footage of a new Bolliger & Mabillard inverted coaster at France's Parc Asterix known as OzIris.
The Spanish soccer club expects to draw a million visitors annually to a resort complete with luxury villas, hotel suites and a yacht marina along with a 10,000-seat waterfront stadium. Real Madrid officials say more than half of the team's 300 million worldwide fans live in Asia and the Middle East.
Like the New York Yankees of American baseball, Real Madrid is built to win championships and loaded with marquee talent like Cristiano Ronaldo, Xabi Alonso, Mesut Ozil and Marcelo Viera. An interactive museum on the island will tell the history of the storied club and its celebrated players. The grandiosity and pomposity of the luxury resort project has already met with derision in soccer-mad Europe, particularly among fans of Real Madrid's arch-rival Barcelona.
This isn't the first time Real Madrid has floated plans for a theme park, previously pitching a plan to add amusement rides and attractions to the team's practice facility near the Madrid-Barajas airport.
Other sports brands have ventured into themed entertainment. England's Manchester United has built branded restaurants in Asia and an "interactive sporting experience" at Macau's Venetian Casino. The Ferrari World theme park in Abu Dhabi features the 149-mph Formula Rossa, the world's fastest roller coaster.
The Real Madrid proposal follows in the wake of a number of ambitious yet unrealized Middle East projects by some of the biggest names in the theme park industry, including Universal Studios, Legoland, SeaWorld, Six Flags and Busch Gardens.


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In the Name of God, Most Gracious, Most Merciful
The question of not having all details of Salah in Quran
How come the details of observing our Contact Prayers are not mentioned in Quran?
The way we observe our Contact Prayers, Salah, is not based on Hadith. Quran teaches us that its rituals were in existence and were delivered and practiced by prophet Abraham way before Quran and prophet Muhammad's time:
[4:125] Who is better guided in his religion than one who submits totally to GOD, leads a righteous life, according to the creed of Abraham: monotheism? GOD has chosen Abraham as a beloved friend.
[22:78] You shall strive for the cause of GOD as you should strive for His cause. He has chosen you and has placed no hardship on you in practicing your religion - the religion of your father Abraham. He is the one who named you "Submitters" originally. Thus, the messenger shall serve as a witness among you, and you shall serve as witnesses among the people. Therefore, you shall observe the Contact Prayers (Salat) and give the obligatory charity (Zakat), and hold fast to GOD; He is your Lord, the best Lord and the best Supporter.
[2:127] As Abraham raised the foundations of the shrine, together with Ismail (they prayed): "Our Lord, accept this from us. You are the Hearer, the Omniscient.
[2:128] "Our Lord, make us submitters to You, and from our descendants let there be a community of submitters to You. Teach us the rites of our religion, and redeem us. You are the Redeemer, Most Merciful.
Muhammad then delivered Quran confirming the fact that he is a strict follower of the religion of Abraham that its rites have been already inherited. The word Millat, used in the following verse means "ways or methods of worship" in the Arabic dictionary. Muhammad followed the rites that were practiced by Abraham:
[16:123] Then we inspired you (Muhammad) to follow the religion of Abraham,* the monotheist; he never was an idol worshiper.
As far as all of our rites, Quran only dealt with whatever got altered since Abraham such as the tone of our prayer (17:110), the basic steps of ablution (5:6), the times of our five daily contact prayers, the command of giving the utmost importance to the Friday Congregational Prayer (62:9), allowing sexual relationship with our spouses during the nights of Ramadan (2:187), whatever is mentioned in regard of Hajj and Umrah, and whatever is mentioned in regard of our Zakat, with the highlight that it is due whenever we collect or receive our income (6:141). Anything in regard of our rituals that is not detailed in Quran has been already preserved by God and passed down correctly and this is basically why it is not detailed in Quran.
Believing in Quran alone mandates the belief in the words stated by God to teach us the above system of how we inherited our rites including of course our contact prayers. This system is spelled out in 16:123, 4:125, 22:78, and 2:127-128. Ignoring this clear system issued by God, and hanging on our personal wishes to find all the details of our rituals in Quran only reflects our disbelief in Quran itself, the lack of trust in its divinity, and the lack of trust in God and His systems. . Indeed, Quran is complete and fully detailed. Part of its complete details is the above system of inheriting our rites from Abraham. Either we believe in it or we choose to be with those who take the word of God partially and conditionally. Do they believe in part of the scripture and ignore other parts (2:85)? Those who do so, are the idol worshipers and dividers in the following verses:
[13:36] Those who received the scripture rejoice in what was revealed to you; some others may reject parts of it. Say, "I am simply enjoined to worship GOD, and never associate any idols with Him. I invite to Him, and to Him is my ultimate destiny."
Divine Authorization of the
Quran's Mathematical Code [13:37] We revealed these laws in Arabic, and if you ever acquiesce to their wishes, after this knowledge has come to you, you will have no ally, nor a protector, against GOD.
[15:90] We will deal with the dividers.
[15:91] They accept the Quran only partially.
[15:92] By your Lord, we will question them all,
[15:93] about everything they have done.
[15:94] Therefore, carry out the orders given to you, and disregard the idol worshipers.


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Great Performances: John Mayer Unplugged
Guitar Shop TV was on hand to hear guitarist extraordinaire and Grammy-Award winner John Mayer unveil and play his new Martin 00-45SC John Mayer Signature Edition.
The instrument is already a collectors item, as only 25 of them were made. It is an extraordinarily beautiful guitar, made with rosewood and Adirondack spruce, and deep, vibrant voicings.
Mayer said he wanted people to buy it not because they… Read More
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Obsidian Entertainment is developing new PC, Xbox 360 and PlayStation 3 Wheel of Time games, announces Red Eagle Games, who in late 2008 picked up the rights to create games based on the fantasy-themed Wheel of Time novels by late author Robert Jordan. Specific game plans are not being laid out at this time, but Red Eagle does express enthusiasm for the deal: "The development team at Obsidian Entertainment has demonstrated time and again that they can successfully blend storytelling with technology to craft a superior RPG game experience," said Red Eagle CEO Rick Selvage. "Obsidian Entertainment is the ideal development partner to help Red Eagle Games take Jordan's beloved characters from the printed page to exciting new forms of interactive media."
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27 May 2013
How Do You Learn Learning?
4 comments:
Hi Christina,ReplyDelete
This is a great post about an incredibly important topic! I truly believe that anytime we have more questions than answers - we are on the right track when it comes to learning about learning (both our own and our students).
I have built a Self-Directed Learning website (www.engagedinmyeducation.com) that I hope will become a common space to share great ideas, practice and resources about SDL and Inquiry-based learning. I would love to post a link or summary post for this article to be featured on the site. What do you think? Are you interested at all?
Thanks again for a well-written post that should resonate with anyone struggling through the BIG QUESTIONS of learning.
Hi Neil,ReplyDelete
Thank you for your time and feedback; yes, learning opens up many questions, far too many to be dealt with in one posting.
Thank you for sharing your site; this one aspect of blogging which I really appreciate, i.e. the dialogue, thought provocation and connectivedness of our concerns and practices.
This is a very important post. I really appreciate the time you took to put together this information. Whether digital, or not, the goal is deep learning and the responsibility to meet the learner where they currently are in the process. Carefully chosen technology for the right persons, in the right context for the right material is an opportunity to open doors to endless meaningful learning. Technology to be included in the 'tech group' of teachers is disastrous. Taking the time to be sure of your goal is the key to learning and having the learner recognize that elusive moment of 'aha, now I get it'ReplyDelete
always insightful.
Hi Maria,ReplyDelete
Thank you for reading and taking time to share your views. Yes, I absolutely agree with you; more than ever learning, how to learn, when to learn has become a choice. The issue which is often on my mind is HOW to help others learn.
More than ever before we live in a world where knowledge is out there ready to be taken, but one has to learn how to do that as well. Having certain knowledge/s empowers and opens up further corridors of learning. It is by belonging to those groups, networks, circles of knowledge that one becomes accepted as a participating member of knowing.
Perhaps it is because of looming end of semester exams, or just because another academic year is ending, but this has been on my mind quite a bit lately.
Thank you again for your time and adding further considerations for me to think about! :-)


text:
Every industry has its jargon. When a waiter, for instance, tells a cook to make a hamburger and "86 the garden," it doesn't mean much to the general public. However, the server and the cook both know that this means a hamburger without lettuce and tomato.
The financial sector is no different. It has its own jargon, shorthand that come in handy when considering an investment or when shouting an order across a frantic trading floor.
How much stock market jargon do you know? Take our quiz and find out..
Posted 1 April 2011


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lol. Kavan's most famous work is dystopian post apocalyptic sci fi.
lol. Kavan's most famous work is dystopian post apocalyptic sci fi.
How would you know? It's unreadable
How do you think I found that out?
Hardy - novels and poetry.
Kipling - short stories and poetry
Edward Thomas - Non fiction and poetry
Plath - Bell Jar and poetry
early Ondaatje is good on poery/prose
By Grand Central Station - Elizabeth Smart
must be others - contemporary writers like Ben Lerner and Maggie Nelson claim to be poets but I've not read enough to be convinced.
The Peregrine by JA Baker - dear god, the prose is good. Cos I can't be bothered to go get the book and type something out, this will have to stand for many other worthy quotations:
""I have always longed to be part of the outward life, to be out there at the edge of things, to let the human taint wash away in emptiness and silence as the fox sloughs his smell into the cold unworldliness of water; to return to town a stranger. Wandering flushes a glory that fades with arrival"
that great 'how to make friends with crows' article that Sufi posted earlier this year is surely an echo of this book too
Last edited by baboon2004; 29-08-2017 at 09:15 PM.
Surprised nobody's mentioned Joyce yet. Perhaps too obvious?
Cormac McCarthy's style in 'Blood Meridian' strikes many as being portentous and even ridiculous, but whether or not it works for you, it's obviously poetic - highly intense, full of quasi/psuedo Biblical intonation. I suppose McCarthy belongs to a tradition of American authors writing in a consciously poetic and archaic way - Faulkner, Melville, et al. (Not to mention Conrad.)
cod-king james and faux-folksiness (forest gump) are the two main modes of american literature.
both equally stupid though the latter is more irritating.
So I wonder what it is this need to tell.
To animate somehow the deathly stillness of the profoundest beauty. Breathe life in the telling.
I think now that maybe true sweetness can only happen in limbo. I don't know why. Is it because we are so unsure, so tentative and waiting? Like it needs that much room, that much space to expand. The not knowing anything really, the hoping, the aching transience: This is not real, not really, and so we let it alone, let it unfold lightly. Those times that can fly.
I woke sometime in the middle of the night and lay in the hammock, wriggled my foot out of the sleeping bag into the chill and found the rough ground with my bare foot and rocked myself back and forth. And watched the stars swim against the mesh of leaves. Like a fish nosing a net.
This is what we are, what we do: nose a net, push push, a net that never exists. The knots in the mesh as strong as our own believing. Our own fears.
Something like laughter. That a flower could be this small, this fleeting, that a snowflake could be so large, so persistent. The improbable simplicity. I groaned. Why don't we have a word for the utterance between laughing and crying?
You can't metabolize the loss. It is in the cells of your face, your chest, behind the eyes, in the twists of your gut. Muscle, sinew, bone. It is all of you. When you walk you propel it forward....Then it sits with you. The pain puts its arm over your shoulders. It is your closest friend, steadfast. And at night you can't bear to hear your own breath, unaccompanied by another. And underneath the big stillness like a score, is the roaring of the cataract of everything being and being torn away. Then, the pain is lying beside your side, close. Does not bother you with the sound even of breathing.
Suppose within each book there is another book, and within every letter on every page another volume constantly unfolding; but these volumes take no space on the desk. Suppose knowledge could be reduced to a quintessence, held within a picture, a sign, held within a place which is no place. Suppose the human skull were to become capacious, spaces opening inside it, humming chambers like beehives.
"The fate of peoples is made like this, two men in small rooms. Forget the coronations, the conclaves of cardinals, the pomp and processions. This is how the world changes: a counter pushed across a table, a pen stroke that alters the force of a phrase, a womans sigh as she passes and leaves on the air a trail of orange flower or rose water; her hand pulling close the bed curtain, the discrete sigh of flesh against flesh."
"As the word of God spreads, the people's eyes are opened to new truths. Until now, like Helen Barre, they knew Noah and the Flood, but not St Paul. They could count over the sorrows of our Blessed Mother, and say how the damned are carried down to Hell. But they did not know the manifold miracles and sayings of Christ, nor the words and deeds of the apostles, simple men who, like the poor of London, pursued simple wordless trades. The story is much bigger than they ever thought it was."
It's the living that turn and chase the dead. The long bones and skulls are tumbled from their shrouds, and words like stones thrust into their rattling mouths: we edit their writings, we rewrite their lives.


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Ron Browz - You Win
"Ron Browz double album Random/Awkward set to release soon! Random is the hiphop album, and awkward is the euro dance album" [m]
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Therefore , why is not able to you just accept a brokerage t
Therefore , why is not able to you just accept a brokerage t
Wiek: 55
Dołączył: 10 Lut 2011
Posty: 10
Skąd: USA
Wysłany: 2011-02-10, 22:56
Therefore , why is not able to you just accept a brokerage t
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NAIROBI (Thomson Reuters Foundation) – Kenya is making great strides in tackling HIV/AIDS, with a fall in the HIV positive population and a surge in the number of people getting tested and receiving treatment, according to a government survey released on Tuesday.
Kenya has the fourth largest HIV positive population in the world, after South Africa, Nigeria and India. But the number of Kenyans living with the disease fell from 1.4 million to 1.2 million between 2007 and 2012, the 2012 Kenya Aids Indicator Survey revealed on Tuesday.
The prevalence of HIV among adults dropped from 7.2 to 5.6 percent in the same period.
"We've made huge progress in Kenya both in reducing the number of new infections and getting people living with HIV on treatment," Maya Harper, the United Nations AIDS country director, said at the launch of the report. "Testing, knowledge of status, male circumcision in Nyanza, access to treatment – I think those have been great leaps forward in Kenya in the last five years."
More than 600,000 Kenyan men have been circumcised through a voluntary government programme since 2008, particularly in the western region of Nyanza, where it has traditionally not been part of the local culture.
Male circumcision reduces the risk of acquiring HIV by more than 60 percent.
"Circumcision scale-up has been more successful in Kenya than in any other African country," said Kevin De-Cocks, director of the Centers for Disease Control and Prevention's Center for Global Health.
Most exciting is the huge increase in the number of Kenyans getting tested. This is important because people need to know that they are infected so that they can seek treatment.
The percentage of adults who have taken an HIV test more than doubled from 34 percent to 72 percent between 2007 and 2012. Two-thirds of those tested have been tested more than once.
The government has campaigned actively for people to find out their status, offering free tests, including at home. About seven million Kenyans now take an HIV test each year.
"The phobia which was there before now seems to have declined," said James Macharia, the cabinet secretary for health. "In the past, people used to get tested for HIV secretly. They'd be going to the remotest testing locations because nobody wanted to be seen entering those VCT (voluntary counselling and testing) locations."
As a result, almost half of HIV positive Kenyans are aware that they have the disease – up from 16 percent in 2007 to 47 percent in 2012.
With more people knowing their status, more people are taking anti-retroviral therapy (ART) to suppress the virus. Not only does this improve their health and their body's ability to fight off opportunistic infections, it also reduces the chance of their giving HIV to others.
Almost nine out of ten HIV positive people who know their status and are eligible for ART are receiving treatment.
One of the reasons that Kenya's prevalence rate remains quite stable is the large number of people taking ART.
"Because of ART, they are staying alive," said De-Cocks.
As a result, the highest HIV prevalence rate in Kenya (9.1 percent) is among middle-aged people aged 45 to 54 – contrary to assumptions that HIV predominantly affects young people.
This is a significant change from 2007, when the highest prevalence was among those aged 25 to 34 (10.5 percent). Prevalence among this age group fell to 6.4 percent in 2012, showing that there are fewer new infections among young people.
Our Standards: The Thomson Reuters Trust Principles.


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Each lesson or activity in this toolkit is related to NASA's Lunar Reconnaissance Orbiter (LRO). The toolkit is designed so that each lesson can be done independently, or combined and taught in a sequence. The Teacher Implementation Guide provides... (View More) recommendations for combining the lessons into three main strands: 1) Lunar Exploration - These lessons provide a basic introduction to Moon exploration. Note that this strand is also appropriate for use in social studies classes. 2) Mapping the Moon - These lessons provide a more in-depth understanding of Moon exploration through the use of scientific data and student inquiry. The lessons also include many connections to Earth science and geology. 3) Tools of Investigation - These higher-level lessons examine the role of technology, engineering and physics in collecting and analyzing data. (View Less)
Materials Cost: $1 - $5 per group of students
In this hands-on experiment, students will investigate the basic principle of photosynthesis and learn how light intensity diminishes as a function of distance from the light source. Questions help learners connect these two ideas to determine if... (View More) photosynthesis could occur at Saturn. (View Less)
Materials Cost: $10 - $20 per group of students


text:
WASHINGTON—Officials in the law enforcement community opposed to legalizing marijuana are urging Attorney General Eric Holder to speak out before election day against three state ballot initiatives that would do just that.
In response, Justice Department spokeswoman Allison Price says the department is not going to speculate on the outcome of the various ballot initiatives in each of the states—Colorado, Washington and Oregon.
Peter Bensinger, a former head of the Drug Enforcement Administration, told reporters that it is important for the public to know the dangers of legalizing marijuana and for the Justice Department to address the issue now.
Among the participants at the press conference were former directors of the White House Office of National Drug Control Policy.
Federal law prohibits production, possession and sale of marijuana.


text:
Cumulus Networks
In 2011, I got a call from longtime friend and colleague Ed Bugnion, who wanted to introduce me to two guys working on a dangerous idea in data center networking – JR Rivers and Nolan Leake.
Dan and Alex have courage of conviction, which drives them to follow an independent path well outside the industry dogma. We have found that such orthogonal, cross-grain thinking stands behind the biggest entrepreneurial success stories.
Redback Networks
I realized that there was a looming existential hurdle to the deployment of broadband networking itself.
Nimble Storage
Varun Mehta and Umesh Maheshwari founded Nimble Storage based on an observation at the foundation of data storage – the physical media itself. Six years later Nimble became a multi-billion dollar publicly traded company, and along the way helped transform an industry.
I first met Jahangir Mohammed, founder and CEO of Jasper in 2002 when he was the CEO of Kineto Wireless. I was struck by his clarity and audacity.
Blue Jeans Network
Krish Ramakrishnan has an uncanny ability to detect fuzzy, early market signals and turn them into clear-eyed strategy. Blue Jeans is the latest example.


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Seemingly destined for a career in the entertainment industry, Nicole Premuto Fountain '03 interned with Miramax Films and World Wrestling Entertainment and worked for Rolling Stone/Men's Journal before tackling PR at MetLife Stadium, East Rutherford, N.J.
From Bruce Springsteen to Bon Jovi and WrestleMania to Kenny Chesney, Nicole Premuto Fountain '03 has worked her fair share of big stages and massive audiences.
But none bigger than the one she will face on Feb. 2, 2014.
"Commissioner (Roger) Goodell said it best at the NFL Draft … we're on the clock," says Fountain, senior manager of public relations and communications for MetLife Stadium, host of Super Bowl XLVIII. "The world will be watching. It's going to be historic."
Fountain is right. An estimated 160 million people will tune in on television and online, in addition to the 80,000-plus fans and media in attendance at the stadium. It's a stage – an opportunity – few marketing and communications professionals experience. And this former Bloomsburg University campus tour guide and Phi Iota Chi sister will be right in the middle of it.
"We're very excited, not nervous at all," says Fountain. "We do this every week. We realize we're going to have a much bigger audience, but that's just more motivation for us."
Unique to this Super Bowl will be the elements, along with its close proximity to New York City. It will be the first Super Bowl played in a cold-weather city where players, fans and halftime entertainers won't have the protection of a dome. The weather is just one of the logistical details and scenarios being discussed and reviewed.
"Our specific roles are still being worked out," says Fountain, adding the bulk of the planning is being done by the NFL and the New York/New Jersey Super Bowl Host Committee. "It's their game. I'm sure I'll be somewhere in a social media command center monitoring and updating our stadium website and social media sites."
Fountain says her colleagues – roughly 70 full-time staff from sales to guest services to electricians – will take a simple, confident approach to game day. As the only facility that is home to two NFL teams – the Jets and the Giants – MetLife Stadium hosts at least 16 games a year. That doesn't include concerts, soccer matches, and possible NFL postseason and college games.
For Fountain, a member of MetLife Stadium's marketing team, these events mean responsibility for media relations and event-day press operations, along with the website and all social media channels. "We do this every week," she says. "We have a small staff, but we're all really involved in event-day operations."
Around the clock
A digital clock near Fountain's office displays a second-by-second countdown to Super Bowl XVLIII's kickoff. It's a constant reminder of how quickly the big event – still months away – is approaching. Fountain admits she seldom notices.
"We're really nonstop here, six to seven days a week from early April into January," Fountain says. "Every day is different. Every event is unique. Each comes with its own challenges."
Over the course of the year, MetLife hosts concerts, international soccer, moto-cross, monster trucks and entertainment events like the recent WrestleMania 29, along with college football matchups. Much like the stadium's schedule, Fountain says she and other staff must be flexible. It's a way of life.
"Anytime you work in the entertainment industry, it's not a 9-to-5 job," Fountain says. "During football season, we're here six to seven days a week. Since MetLife opened, we have had two games on Thanksgiving and a Christmas Eve game.
"Your family needs to understand you may miss a holiday or birthday party," she adds. "There are plenty of times I tell my husband I'm not going to be home this weekend … at all." That family includes husband Justin Fountain '03 and their son, Brecken Niles, born in May 2013.
Around her hectic schedule, Fountain makes community involvement a priority, serving as a board member of the New Jersey Chapter of the Crohn's and Colitis Foundation of America (CCFA). The third annual CCFA Touch Football Tournament — a fundraiser she initiated in 2010 — will be held at MetLife Stadium in October.
'Where? How?'
Although specifics are yet to be determined, Fountain has a basic understanding of what she will be doing during the Super Bowl. "When you have 80,000 people coming into this building, they have a lot of questions (about parking, beverage areas, catching the train)," Fountain says. "Social media has really taken over the game-day experience. You have to constantly monitor it before fans arrive, as they come into the gates, while they're interacting with the event and, eventually, as they're going home."
As Fountain works to make the Super Bowl experience memorable for fans, she expects to be distracted from action on the field and to miss a highlight … or two or three. But she's OK with it.
"You really have to like what you're doing," Fountain says. "I wouldn't do this if I didn't enjoy it." •
Jaime North is marketing specialist and Web editor at Bloomsburg University.
What's super about the Super Bowl?
- The Super Bowl provides an estimated $150 million economic boost to a host area, according to PricewaterhouseCoopers LLP.
- Fans will eat an estimated 1.23 billion chicken wings the day of the game, according to National Chicken Council.
- Nine out of 10 TV viewers will watch the Super Bowl at home or someone else's home, according to the Nielsen Co.
- Domino's Pizza estimates it delivers 11 million pieces of pizza the day of the game, according to Domino's.
- An estimated 11.2 million pounds of potato chips will be consumed during Super Bowl parties, according to the Snack Food Association.
- Antacids sales go up an estimated 20 percent the day after the Super Bowl, according to 7-Eleven Stores.
- Of the 10 most watched programs in American television history, nine are Super Bowls, according to the Nielsen Co.
- CBS charged between $3.8 million and $4 million for a 30-second commercial spot during the 49ers vs. Ravens Super Bowl in February 2013, according to the Washington Post.


text:
Developers are now required to provide Retina-ready app icons when submitting an app to Apple's Mac App Store.
The new compulsory requirement seems to have been put in place by Apple on Tuesday, when developer Daniel Jalkut noted that apps can now only be submitted to the Mac App Store if the application bundle contains a huge 1024x1024 icon.
This pixel-packed requirement will ensure that all icons are suitable for the new MacBook Pro with Retina display, and suggests that Apple is looking towards launching more Retina Macs in the future.
However, these Retina icons mean that apps will be larger download sizes, and will therefore take up more space on a Mac's hard drive. The icons will also take up more of the Mac's memory when rendered, which could cause some older computers to struggle.
Retina-ready apps have slowly but surely been hitting the Mac App Store since the release of the new MacBook Pro with Retina display, but it looks like Apple is trying to push developers in the super high-resolution direction with the new app requirement.
See also:
Why Apple has withdrawn from EPEAT: the MacBook Pro Retina Display battery
Retina-ready Mac apps hitting the market
Apple improves Retina MacBook Pro shipping times
New MacBook Pro 13in Retina Display benchmarks revealed
Apple adds extra moisture sensors in Retina MacBook Pro
Retina MacBook Pro can run three external monitors
Apple's 'a year ahead of the industry' with Retina display MacBook, analyst


text:
|Above the NUSSC First Team BUDS Champions.
NUSSC have competed in a further two rounds of KINGS since my last post, where the mixed First Team (myself and 4 boys) has remained unbeaten and the girls team (myself and 3 other girls) have seen progressive improvement finishing 2nd in the December competition. Unfortunately I will be missing the next KINGS races as I am travelling out to compete in the English Ski Championships in Bormio on February 16th.
|My very fat swollen ankle a couple of days after the fall
During Christmas I found out I have been selected for the 'BUSC Elite Athlete Squad A-Team' giving me the chance to be selected to represent England at the World University Champs. However on December 23rd I sustained an ankle injury whilst out running. I sprained my anterior talofibular ligament and generally feel pain throughout with reoccurring swelling every time I exercise. Liz at Hallam Physiotherapy in Sheffield initially treated me. Since returning back to University I received physio at Newcastle Sports Injury Clinic by Laura; these sessions were paid for through the Universities Elite Athlete Program which I am very grateful for. Needless to say this injury has hindered my performance and fitness since, despite taking measures to speed recovery.
|Above and Below are photos from the Chamonix night
Slalom taken by one of the competitors fathers!
His photos can be viewed at www.damia.eu
A week after my ankle sprain I travelled out to France with the intention to race in 3 slaloms. The two slaloms at Le Corbier were cancelled due to FIS failing to homologate the new race piste in time! This was probably for the best as just getting my ski boot on was too painful. Having travelled the distance I still raced in the FIS Chamonix Night Slalom; my performance was under par but I still finished top 30 and 4th GBR. In the photos to the left it is evident I was in quite a bit of pain due to my hilarious facial expressions; it can also be seen that my left ski (left ankle injured) is skidding slightly from the spray of snow.
Last Wednesday was the BUISC (British University Indoor Ski Championships) Northern Qualifying Round. After the first run I was in second place, just 0.10 of a second behind race leader Jenny Thomas from SKUM (Manchester Uni). However following the second run I finished in 3rd place due to a brilliant performance from Leeds University Skier Abby Clifford whose combined time from run 1 & 2 gave her the overall title. The top 12 girls qualified for the BUISC Final in March –where I hope to finish in a podium position again. The NUSSC First Team finished second in the dual slalom thus securing a place in the BUISC Final also – hopefully we can raise the bar and beat Northumbria in the Final!!


text:
NPR released information on a study March 12, 2011, in the Lancet, indicating 64% of the students that exhibited ADHD symptoms actually had a hypersensitivity to some foods." What's interesting is Jim West has been treating kids with ADHD, ODD, Depression, Anxiety and Mood disorder the same way since 2003. Around 85% of students do not need medication for these issues as often changing diet, adding supplements, and increasing exercise or activity levels can do the trick just like it did for one of Jim West's client, Taylor, seen in the Fox 35 news interview below.
"Hey Dad . . . home for lunch!" It was the middle of the day in Portugal and my nephews came home from school for lunch? My brother David lives in Mafra, Portugal and I was calling him from Orlando. He told me his kids come home from school everyday for lunch around noon and walk back to school around 1:30pm. During our call I recalled this happens in most countries across the globe.
In most countries students have the following routine and eat up to 2-5 lbs of carbohydrates, starch & sugar per month:
- Eat breakfast and burn carbohydrates off walking to school
- Walk back for lunch
- Burn carbohydrates off walking back to school
- Walk home about the time their parents are home from work
- Eat a snack and do homework
- Go outside and play to burn off the carbohydrates again
- Eat dinner and get ready for bed
In the United States the average student eats 21 lbs of sugar per month or 5 lbs per week (4 times the worlds average consumption per person):
- Eat breakfast and sit in a vehicle and carbohydrates turn to sugar
- Eat lunch and sit in class and crash mentally from the sugar rush
- Sit in a vehicle on the way home
- Eat a Snack and and carbohydrates turn to sugar then another sugar crash and sit to do Homework
- Play on the computer or video games until parents get home.
- Eat dinner, sit around watching T.V. and get ready for bed
Jim West, ADHD Expert has been interviewed by local and National TV & Radio including ABC's Medical Minute, Daily Buzz, Fox 35, WESH2 NBC, & WKMG 6 CBS, & more. See below
No matching videos
Sugar and carbohydrates are meant to give us a burst of energy for us to burn. However due to our fast pace and how far we live from school and work we eat carbs (cereal, pancakes, waffles, Pop Tarts) and sit, eat and sit, eat and sit, each day! Additionally, carbohydrates are easy and convenient and as Americans we love convenience. We are the #1 "Consumers" in the world and thus "consume" 6 times more carbohydrates than the rest of the world.
So how does what we eat (too many carbohydrates and sugars) effect us?
- 80% of students in America are deficient in Magnesium. If we consume too many carbohydrates our bodies can not absorb Magnesium. Magnesium is calming, helps us manage stress, increases focus, & it's a natural muscle relaxer.
- If we do not absorb Magnesium it's difficult to absorb Calcium which has many health benefits including improved sleep patterns, bone growth and density, it calms and helps with focus.
- Too many carbohydrates also effects the absorption of chromium which helps to balance our sugar levels.
- 25% of kids between 6-10 years of age have high blood pressure and at risk for hypertension and heart disease
- 1 out of 6 children are obese and 1 out of 3 are overweight.
- Unused Carbs causes spurts of energy, multiple mental energy crashes (trouble focusing on uninteresting tasks at school or work), the strong desire for more carbs and increased appetite, and weight gain.
- These Carbohydrate crashes happen each time we eat too many carbohydrates and effects our mental energy more and more throughout the day as we expend energy. Making it more difficult to do homework, household chores and tasks and effects our moods and how we handle frustration.
- At risk for Diabetes: Diabetes is 95% preventable but recently moved up to the #5 killer of Americans.
What can we do about this?
- Encourage more exercise and physical activity with sports, recreation, family walks, biking, etc.
- Limit computer and video games to 30-60 minutes per day to encourage social and play interaction with peers.
- Increase the Protein to Carbohydrate ratio
- Eat light meals at night with some carbohydrates to help us crash at night and improve deep sleep.
- Avoid Red Meat and Pork at night as it takes 8-12 hours to metabolize. When we metabolize we create energy and dinner time is the time we should be winding down.
- If kids are picky eaters discuss vitamins and supplements with your doctor.
- Watch out for Yellow, Red and Orange Food Coloring according to Dr. Oz
- Red Dye made of Insects?
- Red Food Coloring from Ground up Bugs since the Aztecs?
- Yellow Food coloring linked to a variety of immunologic responses have been attributed to tartrazine ingestion, including anxiety, migraines, clinical depression, blurred vision, itching, general weakness, heatwaves, feeling of suffocation, purple skin patches, and sleep disturbance. Certain people who are exposed to the dye experience symptoms of tartrazine sensitivity even at extremely small doses, some for periods up to 72 hours after exposure. In children, asthma attacks and hives have been claimed, as well as supposed links to thyroid tumors, chromosomal damage, and hyperactivity.
- Orange food coloring is a synthetic yellow azo dye, manufactured from aromatic hydrocarbons from petroleum.
- Complimentary Copy of the Diet and Information on the Supplements for ADHD
Changing how we eat directly effects how we think, feel, and act! Start today to modify how we eat at home, work and school and see a huge difference in improved focus, productivity and energy levels. Please consult with your physician about this article as everyone's nutritional needs vary.
NPR Story – The Lancet Journal did a study: "Diet May Help ADHD Kids More than Drugs."
Jim West has presented "Food for Thought" for University of Central Florida medical clinics, Lake Highland Preparatory School's Edison program, Pediatricians and others. For helpful resources to save time by solving other parenting challenges visit our website or read more of our blogs: Total Life Counseling Center
NOTE: you can freely redistribute this resource, electronically or in print, provided you leave the authors contact information below intact.


text:
I've never been one for wearing a white "doctor" coat when I'm seeing patients at the clinic, possibly because I'm not a doctor (I'm a Physician Assistant), but most likely because, as a patient, those long white lab coats always made me feel a little uncomfortable.
It's one thing to have your surgeon all wrapped up in expensive sterile gowns and masks. It makes her look all expert and technical. They say that "practicing" medicine is an "art," and those are two words I really don't want to think about before someone puts a scalpel through my belly button.
But when a guy has finally worked up the nerve to come in to the clinic to confess that ol' Johnson hasn't been showing up to work on time lately, it doesn't seem right for him to have to tell his intimate details to someone who looks like they'd rather be in the back room doing experiments on small furry animals.
I do, however, believe I should dress professionally when seeing patients at the clinic. This is something I haven't had to do in a long while, mostly because as a novelist I could work in just a thong if I wanted, and as the Assistant County Medical Examiner I never found that my patients cared one way or the other what I was wearing. But for my cash-paying patients who are actually living and breathing, I think it's reassuring that I at least appear to know what I'm doing.
So I put on a tie.
You might be wondering where I'm going with this, but let me assure you, I've kind of forgotten.
Oh yea. Shirts. Ironing shirts. This is all going to lead somewhere. I promise.
Stacey is generally the one in the family to do the majority of the laundry, not because of any sense of traditional male-female household duties, but simply because it fits more easily into her schedule and gets her out of having to unclog toilets. But while I enjoy the luxury of finding my socks magically matched and my boxers neatly folded, I am man enough not to risk my life by asking her to iron my shirts for work.
Ironing shirts is not an entirely unpleasant task, and it's something I'm actually pretty efficient at doing. Over the years, I've learned to do the various parts of the shirt in a strategic order and have developed a particular rhythm, so it really doesn't take long once the iron's heated up. Kind of like sex.
So, I was ironing my shirts the other night, and it occurred to me as I ran the iron over the label on the collar that the little tag was neatly embroidered with the words "no iron fabric."
"Well now," I thought, "wouldn't that be convenient." That's actually not true. What I thought was, "You lying SOBs!"
The other day, Stacey mentioned something she had read in a magazine article, that one of the things the early American settlers thought was such an incredible luxury here in the New World was that they could be warm in the winter. And I'm like, "Huh?" The terms "early settlers" and "warm in the winter" seem to me to go together like "the first Thanksgiving" and "microwavable stuffing mix."
But as we discussed it further, it started sounding more reasonable. Why had the settlers left Europe in the first place? We are taught they were fleeing religious persecution. But really, if you are reasonably well fed and comfortable, are you going to throw your family into the rank bilge in the bottom of some funky rat-infested wooden boat and risk scurvy and plague just so you can more freely burn witches?
No. You do those things because you are cold and hungry.
Actually, it seems perfectly reasonable that witch-burning became so popular in the New World simply because it was so cheap and easy. There were trees everywhere, just begging to be cut down for firewood! No more sending little William to chase after the coal wagon to fight other children over the spilled crumbs and dust. That was back when a lump of coal in your Christmas stocking actually meant something! In the New World there was firewood in abundance; all you had to do was hack the dang tree down with an axe, buck it into rounds, split it with a maul, stack it in the woodshed, and then haul it into the house. There! You could be warm in the winter!
So as I was working the wrinkles out of my "no iron" shirts and about to express my indignation at this horrible inconvenience, it occurred to me that I should just shut up.
There has been grumbling at our house that we are so "ghetto" because I occasionally drive the kids to school in a less-than-latest-model pickup truck and our home theater has only a 42-inch screen. For Christmas, my youngest has expressed that he will be utterly disappointed if he does not receive his own HDTV and a $500 rapid-fire Airsoft machine gun. Oh, and a puppy.
I'm thinking we should all just be grateful that we're reasonably warm. I'm thinking about a lump of coal.
Craig Danner is a novelist and a Physician Assistant who lives and works in Hood River. You can contact him at 541 436-4144 or email firstname.lastname@example.com.
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Single Ascending Dose Trial in Patients With Type 2 Diabetes
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01492465
Recruitment Status : Terminated (Decision by Sponsor)
First Posted : December 15, 2011
Last Update Posted : February 15, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Diabetes Mellitus
|Drug: AMG 876
|Phase 1
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|47 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 876 in Subjects With Type 2 Diabetes
|Study Start Date :
|November 2011
|Actual Primary Completion Date :
|July 2012
|Actual Study Completion Date :
|October 2012
|Active Comparator: AMG 876
Drug: AMG 876
Ascending single doses of study drug administered SC, with one cohort administered IV
|Placebo Comparator: Placebo
Drug: AMG 876
Ascending single doses of study drug administered SC, with one cohort administered IV
- Subject incidence of treatment-emergent adverse events [ Time Frame: 29 days ]Physical examinations, vitals, clinical laboratories, and ECGs
- Safety laboratory analytes, vital signs, and ECGs [ Time Frame: 29 days ]laboratory analytes, vital signs, and ECGs
- Subject incidence of anti-AMG 876 antibodies. [ Time Frame: 29 days ]laboratories analytes
- AMG 876 serum PK parameters [ Time Frame: 29 days ]Concentration-time profiles for AMG 876
- Pharmacodynamic parameters: [ Time Frame: 29 days ]Concentration of fasting glucose, insulin and c-peptide levels; Concentration-time profiles and AUC for metabolic parameters (eg, glucose, insulin, c-peptide, glucagon and free fatty acid concentrations) following a mixed meal tolerance test; Lipid levels (ie, total cholesterol, LDL, HDL, and triglycerides); Body weight.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Subject has provided written informed consent
- Men and women between the ages of 18 and 65, inclusive at the time of randomization
- Women must be of documented non-reproductive potential (ie, postmenopausal [see definition below]; OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral oophorectomy).
- Diagnosed with type 2 diabetes
- HbA1c ≥ 6.5% and ≤ 10%
- Fasting C-peptide value ≥ 0.8 ng/mL
- Men must agree for the duration of the study and continuing for 4 weeks after the dose of study drug, to practice a highly effective method of birth control. Highly effective methods of birth control include sexual abstinence, vasectomy or a condom with spermicide (men) in combination with either barrier methods, hormonal birth control or IUD (women).
- Men must agree to not donate sperm for the duration of the study and continuing for 4 weeks after the dose of study drug.
- Body mass index between ≥ 25.0 kg/m2 and ≤ 40.0 kg/m2 at screening
- Negative screening test for alcohol and potential drugs of abuse at screening and day -2, unless medication is prescribed by a physician and approved by the principal investigator and Amgen medical monitor
Exclusion Criteria:
- Men with partners who are pregnant at the time of screening or men with partners who plan to become pregnant during the study
- Women who are pregnant or breastfeeding History or evidence of a clinically significant disorder, condition or disease that, in the opinion of the principal investigator or Amgen medical monitor would pose a risk to subject safety or interfere with the study evaluation, procedures or completion
- Evidence or history at screening of diabetic complications with significant end-organ damage, eg, proliferative retinopathy and/or macular edema, creatinine clearance < 60 mL/min/1.73m2 (calculated using the Modification of Diet in Renal Disease formula), or macroalbuminuria (ie, ≥ +1 proteinuria on urinalysis), diabetic neuropathy complicated by neuropathic ulcers, or severe autonomic neuropathy with gastroparesis, chronic diarrhea, or hypoglycemic unawareness
- Significant cardiac disease, including but not limited to evidence or history of coronary artery disease, unstable angina, congestive heart failure, known arrhythmias of ventricular etiology, unexplained syncope or syncope/seizures related to arrhythmia
- Positive for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (Hbs Ag), or hepatitis C virus antibodies
- An unstable medical condition, defined as having been hospitalized within 28 days before day -1, major surgery within 6 months before day -1, or otherwise unstable in the judgment of the investigator (eg, risk of complications or adverse events unrelated to study participation)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01492465
|United States, Nebraska
|Research Site
|Omaha, Nebraska, United States, 68154
|United States, Texas
|Research Site
|San Antonio, Texas, United States, 78209
|San Antonio, Texas, United States, 78209
|Study Director:
Additional Information:
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01492465 History of Changes
|Other Study ID Numbers:
|First Posted:
|December 15, 2011 Key Record Dates
|Last Update Posted:
|February 15, 2013
|Last Verified:
|February 2013
Keywords provided by Amgen:
Type 2 diabetes
Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases


text:
THOR: Transformable HOvering Rotorcraft, Singapore University of Technology & Design, Singapore
21st July 2017, 08:38
25th August 2017, 22:49
Trinity, tricopter, Canberra UAV, Canberra, Australia
14th May 2017, 23:05
Spry, waterproof sport drone, Urban Drones, USA
22nd September 2018, 14:18
16th November 2015, 10:02
Airblock, programmable and convertible hexacopter drone, Makeblock Co., Ltd., Shenzhen, China
15th June 2018, 14:25
16th November 2015, 09:49
Airborg H8 10K, hybrid gas-electric octocopter, Top Flight Technologies, Inc., Malden, Massachusetts
17th December 2017, 14:14
Heavy-duty industrial drones, Aerones, Riga, Latvia
4th April 2018, 11:22
Gimball, spherical helicopter, Laboratory of Intelligent Systems and startup Flyability, Lausanne, Switzerland
23rd March 2018, 15:43
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- Television > The Walking Dead > Promotional Photos: Season Six
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Yes. @kevinbacon @justinlong https://t.co/L9jbArR2GU
Reunited... 💗🎉 with my friend @TylerJamesWill
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Very happy to share this news :) https://t.co/zFaJ6iXcN6
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Discussion in 'Feature Requests' started by iDen, Mar 14, 2013.
Any plans regarding support of httpd 2.4 in ISPconfig v 3.0.5.x ?
Is there already a Linux distribution that ships with apache 2.4 as default?
There is distribution with 2.4 rpm compiled by me with provided spec.
Syntax differs from 2.2 ...
Fedora 18 has.
RHELv7 is announced to be available this fall, it will have.
So it was just question.
We will add support for apache 2.4 off course, but I can not give you a date when it gets finished.
Hi Till,
What happens if I install this, make the required changes (such as AUTH is different) and then later upgrade ISPconfig? Does ISPConfig re-install Apache 2.2?
ISPConfig odes not install any software. If you change sourcecode of a software and install a update of that sotware, the update will overwrite your custom changes.
Wow wow !!!
Just saw in Roadmap that you have added plans to support Apache 2.4 in next minor release.
Does it mean that ISPconfig will support at least new mod_proxy_fcgi for better PHP-FPM integration?
Help old FastCGI die
Of course we understand that such additions will make release available not so soon.
there is bug with apache 2.4.x
mod_proxy/mod_proxy_fcgi right now doesn't support unix sockets to connect with php-fpm, only tcp.
For 188.8.131.52 we plan to support the same features that are available for apache 2.2 in ISPConfg, so basically we will add code to support the new config syntax. mod_proxy_fcgi is not on our roadmap yet. Feel free to make a feature request for it in the bugtracker, in case that there is no such requestyet (havent checked it).
Is it possible to "cherry-pick" the already completed task into an existing 188.8.131.52 installation?
I had to upgrade an OpenSUSE 12.3 box, and in the next distro release 13.1 there's no Apache 2.2 available anymore.
No, thats not possible. But 126.96.36.199 will get released soon anyway. If OpenSuSE has a apache compat module like debian, then apache 2.4 should work with ispconfig 184.108.40.206 as well.
Not to my knowledge.
It might be that the com´pat module s installed by default and you just have to enable it. This is the module I refer to:
which makes apache 2.4 compatible with the "old" apache syntax used by ispconfig 18.104.22.168.
Indeed. It's compiled in statically.
idefix:~ # apache2ctl -M|grep access
access_compat_module (static)
Upgraded a OpenSUSE 12.3 box to 13.1 just now, and it seems to run smooth until now.
Some "Options" directives had to be altered (all Options must have a + or - sign in front of it, or no option must have it, but not mixed), and "a2enmod socache_shmcb" was necessary. That's all.
idefix:~ # apache2ctl -M|grep access
access_compat_module (static)
Separate names with a comma.


text:
No, I'm not talking about the good kind of hacking, like the AEC Hackathon. I'm talking about the kind of hacking that steals your identity and buys a diamond necklace for some anonymous Russian mistress! The kind of hacking that sneaked into Target retailers and grabbed millions of PIN's from register transactions. How did they get access? Through an HVAC contractor. The Target corporation felt there was a significant benefit from facility energy savings in allowing broader access and connections to heating and cooling systems. Does this benefit outweigh the potential security risk?
A recent article in the New York Times by Nicole Perlroth ("Hackers Lurking in Vents and Soda Machines") highlights a growing danger of hackers gaining access to corporate networks in some uncommon ways.
"They came in through the Chinese takeout menu."
This got me thinking about the all-too-cool initiatives we are pushing in the AEC industry. Why not connect BIM to facility management (FM)? One of the most recent marketing emails I received is for YouBIM – a cloud-based BIM solution for facility management. Check out their introductory video. What happens when we start connecting all the players in the design and construction work flow with cloud-based BIM data? What happens to the benefit of 'big data' when it starts to communicate and co-mingle with consumer profiles? Food for thought…


text:
In nearly all the 50 U.S. states, lawmakers have taken aim at law-enforcement's use, or potential use, of unmanned aerial systems (UAS). As of mid-July, the American Civil Liberties Union was tracking legislation proposed in 42 states, enacted in six states, and still active or pending in 27 states.
At least one leading researcher in the field is asking for a little time and a little space before clamping down on what he and others believe could put useful and non-threatening technology into the hands of small police departments across the country.
"Like most technologies it needs to mature a little bit before legislatures try to control it," says Allan Frazier, an assistant professor in the University of North Dakota's aerospace department who can claim not only a raft of FAA pilot ratings including air transport pilot, helicopters and gliders, but 33 years as a police officer and deputy sheriff in three states.
"If you start enacting laws now to control small UAS, it's like telling the Wright Brothers they can't do test flights at Kitty Hawk," Frazier says. "We don't know what we don't know unless we're able to utilize the technology."
Frazier helps run a collaborative research project at UND involving the Grand Forks County Sheriff's Office and small UAS manufacturers Aerovironment and Draganfly. The team is making air vehicles available to agencies in a 16-county area of northeastern North Dakota free of charge, thanks to grant funding aimed at developing the concept of operations for UAS in civil airspace and in a law-enforcement and public safety setting, creating the right training curriculum for officers and pilots and evaluating how effective the systems are in actual police and public safety work.
So far the research is pointing the way towards safety, community involvement and transparency, along with a checks-and-balances dispatching system that ensures compliance with FAA and university rules, ethical standards and the public's expectations for how unmanned systems will, and won't, be used.
Frazier believes there's real opportunity.
There are 19,000 law-enforcement agencies throughout the U.S., and some 80% of them employ fewer than 100 officers -- the benchmark at which an agency can typically begin thinking about using some sort of aerial asset. For these agencies, small, portable UAS can provide a cost-effective way to conduct lost-person searches, assess disaster damage, document crime and traffic accident scenes, help monitor traffic at major events and yes, help chase bad guys if the need arises.
Proof-of-concept work and research is underway in seven states with nine public-safety agencies, and a lot of questions need to be answered, not only by law-enforcement but by the courts. So far the legal system has not had to deal with the Constitutional questions raised by using this technology -- how does a UAS operation fit into the bounds of what constitutes improper search and seizure under the Fourth Amendment? -- but Frazier predicts that it will.
Meanwhile, premature action by states could cut off development not only of technologies but of policies and procedures to ensure a balance between privacy and public safety.
Frazier tells attendees at AirVenture 2013 in Oshkosh, however, that federal standards will likely prevail.
"I think it's a federal issue and I think it's preempted by federal statutes," he says. "The states, quite frankly, have little business dealing with something that occupies our airspace."


text:
This USB Driver Pack Support the following Windows OS versions:
Windows XP / Windows Vista / Windows XP 64 bit / Windows Vista 64 bit / Windows 7 / Windows 7 64 bit / Windows 8 / Windows 8 64 bit.
Download Link: Direct Download Link for Samsung Galaxy Grand DUOS GT-I9082 USB Driver.
Installing The Samsung Galaxy Grand DUOS GT-I9082 USB Driver:
1- Download The Samsung USB Driver For Mobile Phones from the link above.
2- Double click on it to run it.
3- Now you have to follow the installation steps one by one, Like you do with any other Windows install program.
4- Wait until the installation process finishes.
5- Restart your Computer.
6- Now use your Samsung Mobile Phone USB cable to connect it to your Computer.
7- Wait until your Computer detects the new connected device.
8- Windows will install the right Driver for your Samsung Mobile Phone, So give it some time.
9- When the driver is installed, Windows will tell you that a new device is installed and ready to be used.
10- Done.


text:
As our readers know, we've got a wheel fetish and Ric Hjertberg in a lab coat with a set of prototypes gets our interest.
Full report is coming – Andrew got an hour with their team and returned in full-on engineering geek mode.
They're from Madfiber, Ric's latest company. Bike Intelligencer profiled them last month.
Uploaded by andrew_f_martin | more from the Bike Hugger Photostream.


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I would have done LIVE commentaries if I get the show LIVE. I'M HOOKED. GONNA WATCH EPISODE 5 TODAY... But I think someone spoiled it for me accidentally saying it's a NEL.Do you know how hard it is to resist spoilers and not find out what happens? It made me SUPER excited~! Watching the teachers survive LEG AFTER LEG = They are like my new Ann Marie and Tracy, except they don't give up and keep trying!!! If they are not gone next, I WILL BE SHOCKED!
It's just unaired roadblock, mate. Every team had to use boogie boards to surf their way to the bottom where they would grab their next clue. Sounds pretty easy, haha.
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