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|2006-05-03, 12:09
|Link #81
1982 tuga
Join Date: Aug 2004
Location: Portugal
The only thing I'm confused about is the FX insertion you're doing. Those FX are "remastered" versions of the original or are you adding extra FX that weren't in the original audio?
As for your Captain Harlock's releases, I wasn't aware of the similiar remasterization you made; one more good reason for me to download it. ^^
What's more interesting is that I'm not the only one to do such a "remasterization" on a fansub's audio afterall. I once used Touch's first episode release by Baka MX & Meisei for a personal test. I used the OST I had downloaded and mixed it with the fansub's "no treble audio". It was tricky as hell! But it did sound better. It was for personal use, though.
Even more interesting is that I just thinking the other day of planning to do a similar thing with the "Idol Densetsu Eriko" raws I was going to sub.
Good luck with the rest of Sailor Stars' remasterization.
|2006-05-03, 18:38
|Link #82
[Live-eviL] Naughty Boy
The sound effects are a mix of old and new. For instance, in episode 167 the birds and other ambient sounds were all new. The on-screen FX, with a few exceptions, were all from the show. I try to use as must original stuff as I can. Captain Harlock is also a mix of old and new sounds.
I did discover that the system used to mix the 5.1 track for 167 was not callibrated properly. As a result, a few of the channels (notably the surrounds) were out of balance. If you had a lot of reverb in 167, that would be why. This will be fixed in future episodes. Sorry for the mixup and thanks to those who pointed out the issue. I promise that I will get better! ^_^
168 is progressing well. This time we'll have a more polished mix with SFX in addtition to the music.
Thanks so much!
|2006-05-12, 11:37
|Link #85
nop, you better go back and read again, it's not that they go to their past lives, the just turn into females, just accept it!
|2006-05-12, 15:36
|Link #86
Ok I was bored and starded to read the thread here.
I saw some one puts their 2 cents so let me place a lot of nicles....
Since I lived in Mexico, Sailor moon aired here muchhhh earlier than in the
US, althoug I have to admit that the translation and also the story was
changed in about 35% of the whole series, back in jan 1999 a local TV
station in Mexico (TV azteca) aired the Last episode of sailor moon (200) so
I was able to see the whole series before ep 38 air in the Us, after that I
became a sailor moon freak, and my favorate season is prescisly sailor moon
SuperS (the second part: neherenias comeback wich is already considered as
sailor stars) and the last Saga, I was able to see the series like 4 times
so I got my hands on the manga and dicovered a lot of things, apart from
investigating from oficial sources from Mrs Takeuchi about a lot of sailor
moon issues, but I would like to share all my years of understanding of a
lot of things that appear in the anime and the manga, so please take in mind
that sailor moon has 2 diferent stories, and as far as I'm concernd if you
want to make sence of a lot of things in the anime comparing it to the
manga, it ain't gonna happen.
Ok these are practitly the most popular issues in discution:
1.- are the sailor stars gay, trasnvest., in discuise, or are
Manga: The sairlor stars ARE GIRLS, they came to earth searching for
their princess, but just dress like guys becuase it's like some one else
already said that it was more acceptable for a male to be searching for a
princess ON EARTH, not in their home planet.
Anime: Almoust the same thing as the manga, but like order of things,
you can't be sailor if you are a guy, so they just turn back into girls.
let's look at it this way:
you loose a princess, you know that she probably is on earth, since you're a
girl, it's gonna be hard to get any attention to be helped in looking for a
very important person specialy if their not from earth, What to do to find
her faster and with a lot of help without actually asking directly for it?
"turn" into a guy, since a lot of people in this case girls fall for a great
pop group what better way to get a record deal and with a good hit, turn
superstar, make a lot of concerts and the more popular you get, the more
chances of your princess to hear you either on the radio or on TV with your
secret calling in your songs, don't you think she's gonna go: " oh! there
they are!" makes sense to me they way they maneged it.
2.- what's up with Haruka and Michiru? lesbis? friends? cousins?
Manga: In the manga THEY ARE lesbians, although Haruka likes to dress like a guy, let's say that he's the guy of the relation ship while Michiru is the feminant one, and yes, you can see that haruka DID kiss Usagi a little while after they met, the manga points that Haruka kinda has the hots for Usagi in a certain way, but always stays with Michiru.
Anime: It was not very clear, wheather they had a relation ship or not, the somethime look like a couple but then some times they seem like really really close friends, so the animators left that to the audience to decide. but Haruka could be considered like a tomboy in her regular self, in one epidose when Rei was spending a lot of time with her, Nicholas got jelous and thought that haruka was indeed a man, challenging her to give up on Rei becuase he was in love with her, so his surprise, Rei tells him that Haruka is just a girl, but once she transforms into a sailor, she's very feminant, that's something that Naoko wanted the animators to leave in the anime.
3.- Is Seiya a guy or a girl for those of you that wonder why he/she has the hots for Usagi.
Manga: Since Seiya is a Girl, it's obvious that she's a lesbi, we tend to see a lot of lesbianisim in sailor moon, although Naoko doesn't present that it's a bad thing in the story, and we need to say that in Japan, being GAY is not as rejected or seen as bad as in other countries like in the US, Japan accepts a lot of GAY people so Naoko just addid a little bit of that acceptance in her mangas.
Anime: Since we tend to see that seiya normally hits on Usagi while in his guy form, it's the same thing, as in the manga BUT they don't openly want to present that in the anime. So yes.. Usagi has been kissed twice by lesbians, but she's not a lesbian, so she doesn't take it seriously.
4.- Did Mamoru really die at the end becuase he's never seen thru out the last saga?
Manga: Mamoru DOES die, but it was not until Sailor moon Reached Galaxia and had to kill him personally, he was just like Galaxias sailors under control, the only way to save them was to kill them in a sort of way...
Anime: same thing except that Sailor moon discovers it when she's in the last fight with Galaxia that she notices Mamorus Seed.
And just one last thing but only in the Manga:
did Mamoru and Usagi "DO IT" .......
YES! at the end, after a long 1000 year journey back to earth after defiting Galaxia, they arrive reborne and well.. after 1000 years of traveling, they couldn't wait anymore, so yea they DID IT, that's when Mamoru tells Usagi to marry her. a few days later, they marry and Usagi says in the mittle of it all when she looks at Mamoru and you see a glare shine she says "A new star is born" that's just her saying that she Pregnant, you guest it... Chibi-Usa.
I think this is enogh for now.
In my opinion, I Loved the Manga much much more than the anime, the anime is great but the manga is a 5 star story.
|2006-07-09, 08:03
|Link #87
1982 tuga
Join Date: Aug 2004
Location: Portugal
Live-Evil has released episode 168 of Sailor Moon (ep 02 of Stars). Since no one has posted any comments on this, I decided to take the initiative:
Comparing it with 'FoT & A-Works' release, Live-Evil's image isn't as sharp. What was the raw used?
This is not a rant, this is more a curious technical question, since I like to analize videos. In fact, it's great that there is more than one fansub group working on this series. This way, there's a smaller chance of being dropped by everyone.
|2006-07-09, 10:04
|Link #89
1982 tuga
Join Date: Aug 2004
Location: Portugal
Although I did fail to check the video codecs used, that's besides the point, because sharpness isn't 100% related to the codec used.
Personally, what I thought was the raw wasn't DVD and was LD instead. There was nothing else implied in my statement...
|2006-07-09, 11:00
|Link #90
Live-eviL Staffer
Raw source was DVD's.
I own R through Stars on Region 2's.
h264 does make a difference on sharpness. I can see the difference myself. I'm not the worlds best encoder and I take advice from others within L-E about how best to filter video.
But in all honesty I care not for whether my encodes are that extra 5% sharper. These are not meant to replace buying the original Region 2 DVD's. As long as its watchable without heavy pixellation or very noticeable artefacts then all is good. If I want to be a quality whore I'll just pop a DVD in the drive :E.
PS By comparing sharpness you were making a judgement :P. Oh and I wasn't being defensive. Merely asking that if people wish to draw comparisons on encode quality that they compare the right version
|2006-07-09, 15:42
|Link #91
1982 tuga
Join Date: Aug 2004
Location: Portugal
|2006-07-22, 14:57
|Link #95
Senior Member
Join Date: Apr 2003
Location: United States
Age: 30
|2006-07-25, 02:42
|Link #96
Weapon of Mass Discussion
Join Date: Feb 2003
Location: New York, USA
|2006-11-05, 16:08
|Link #99
Join Date: Apr 2006
I found out the Sailor Stars I saw on TV was edited. in the version I saw they made it so the new people were actually females but that they just dress like guys to be popular/succesful in the music business and I'm guessing the transformation thing was edited since it's pretty much male->female. then I found they are actually guys in the jap version.
|2006-12-10, 06:55
|Link #100
Baka Neko!
|magical girl, shojo
|Thread Tools


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This is not an offer for credit and should be used for estimation purposes only based on the information you provided. You should not base your decision on this estimate alone. Title, registration, tax and other fees, and personal circumstances such as employment status and personal credit history, were not considered in the calculations.
Ski - Hydraulic twin tube
Front Track - Arctic Cat® twin tube
Rear Track - Arctic Cat® 2.0 twin tube
Travel - 9.5 in. (24.1 cm)
SLIDE-ACTION Rear Suspension, coupling blocks, Torque-Sensing Link rear arm, adjustable torsion springs and fiberglass overload springs
Travel - 13.5 in. (34.3 cm)
Drive - Arctic 6 post (rpm sensing)
Driven - 10.4 in. (26.4 cm) diameter Arctic (roller cam)
Drive System - ACT Diamond Direct Drive
Wide - 8 in. (20.3 cm)
Runner - Single with carbide


text:
June 1997
CD4 counts and HIV RNA levels do predict rate of disease progression
People in the HIV/AIDS community have long debated the merits of using surrogate markers like absolute CD4 counts and HIV RNA levels to assess disease stage and/or gauge the effects of treatment. The data from two recent studies may help resolve this issue -- and provide practitioners with a clearer picture of the clinical utility of these widely used laboratory tests.
Phillips et al. examined the impact of nucleoside analog therapy on CD4 counts and HIV RNA levels in peripheral blood, in an attempt to correlate those two markers with disease progression. These investigators evaluated the clinical data from two studies that used ZDV and 3TC in combination. A total of 620 patients participated in those studies, and all of the subjects were followed for at least one year. CD4 and HIV RNA levels were assessed every four weeks throughout the study period.
The authors found that desirable changes in these two surrogate markers -- increases in CD4 count, decreases in HIV RNA level -- correlated with a diminished relative hazard for progression to a diagnosis of AIDS or a new C.D.C. stage of AIDS. These findings led Phillips et al. to conclude that therapy-induced reductions in viral burden contribute substantially to the clinical improvement seen in patients treated with nucleoside analogs. Changes in CD4 counts also correlated with changes in clinical condition, but the association was not as strong.
Phillips and coworkers also found a correlation between clinical status and surrogate markers in peripheral blood -- a finding which reinforces the theory that HIV activity in peripheral blood is a reflection of what is occurring in the body as a whole.
This additional evidence that HIV RNA levels are a good gauge of clinical status and disease progression makes it all the more important to know how accurate such assays are. Practitioners will therefore be interested in a recently published analysis of HIV quantitation assays in individuals with relatively high CD4 counts. Paxton et al. evaluated 45 subjects, all participants in a vaccine trial, in an attempt to ascertain the degree of variability among several HIV RNA assays that are currently in clinical use. Two groups were examined: 30 patients with CD4 counts above 600 cells/mm3 who were not receiving antiretroviral therapy, and 15 patients with CD4 counts between 400 and 550 cells/mm3 who were on ZDV monotherapy. The participants were followed for more than one year, during which time their viral burden was assessed at regular intervals by three assay methods: proviral DNA, viral RNA, and cell-associated infectious virus.
All of these means of measuring HIV RNA correlated well with one another in individual patients. However, assay that measure plasma viral RNA levels were judged to be the most consistent and reliable. The authors conclude that this method of quantifying viral load is the best of the currently available clinical tools for tracking an individual patient's response to antiretroviral treatment.
Phillips AN, Eron J, Bartlett J, Kuritzkes DR, Johnson VA, Gilbert C et al. Correspondence between the effect of zidovudine plus lamivudine on plasma HIV level/CD4 lymphocyte count and the incidence of clinical disease in infected individuals.AIDS 1997;11:169-75.
Paxton WB, Coombs RW, McElrath MJ, Keefer MC, Hughes J, Sinangil F et al. Longitudinal analysis of quantitative virologic measures in human immunodeficiency virus-infected subjects with >400 CD4 lymphocytes: implications for applying measurements to individual patients.J Infect Dis 1997;175:247-54.
Dr. Paul A. Volberding, editor-in-chief of HIV Newsline, comments:
It was CD4 counts which first identified and characterized what came to be called the acquired immunodeficiency syndrome, and since that time clinicians have been using CD4 lymphocyte depletion as an indirect means of diagnosing AIDS and HIV infection, tracking disease progression, and gauging response to therapy. Since early last year, when HIV RNA assays became commercially available, practitioners who treat patients with HIV disease have been able to measure viral load -- and response to therapy -- directly, using this valuable new clinical tool (see "The HIV RNA Assay," Vol. 2, No. 2, pages 27-30; and "Guidelines for the Clinical Use of the HIV RNA Assay," the PULL OUT AND SAVE feature in that same issue).
The work of Phillips et al. confirms the clinical utility of both the CD4 count and the HIV RNA assay in staging patients and assessing their response to antiretroviral therapy. The work of Paxton et al. suggests that assays that measure plasma RNA levels offer clinicians the most reliable means of determining the level of viral activity in a particular patient. As such, they provide practitioners with the best method of measuring how rapidly and how completely a given patient is responding to a given therapeutic regimen.
Adding clofazimine to clarithromycin and ethambutol does not improve symptoms or survival
Last year we reported the preliminary results from a clinical trial that randomized AIDS patients with MAC to one of two multidrug regimens: clarithromycin (500 mg b.i.d.) plus ethambutol (15 mg/kg/d) with or without clofazimine at a dose of 100 mg per day (see "Fine-tuning the medical management of MAC," Vol. 2, No. 2, pages 34-35). Those results have now been peer-reviewed and published in the journal AIDS, with clarifications and additional observations. The investigators find no advantage to the three-drug regimen for any of the following parameters: development of negative blood cultures for mycobacterial organisms, time to relapse of bacteremia, improvement of constitutional symptoms (such as fevers and night sweats), and adverse reactions to medications.
We previously noted that a significantly higher percentage of patients randomized to the three-drug MAC regimen dropped out of the study due to adverse reactions, but the published report amends this observation: 11% of those on two drugs and 14% of those receiving clofazimine left the study because of adverse reactions attributed to the medications, a difference that was not statistically significant.
More patients randomized to the clofazimine arm died during the study (Figure). Further analysis of the results reveals that patients randomized to three drugs had higher mycobacterial colony counts than patients in the two-drug arm. The median number of colony forming units (CFU) was 152/mL blood in patients in the two-drug cohort versus 1907/mL blood in those who also got clofazimine.
The investigators assert that this imbalance was due to chance. The higher mortality rate noted among clofazimine recipients (61% vs. 38%) may have been due to their higher baseline CFU levels rather than to the toxicity of clofazimine. While other investigators have found an association between mortality and mycobacterial load in AIDS patients, the authors suggest that the issue is unresolved. In any case the increased mortality in the three-drug arm is another argument against including clofazimine in an anti-MAC regimen.
Chaisson RE, Keiser P, Pierce M, Fessel WJ, Ruskin J, Lahart C et al. Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection.AIDS 1997;11:311-317.
Dr. David Hardy, a member of the editorial advisory board of HIV Newsline and the author of "Recent Advances in Prophylaxis for MAC" (Vol. 1, No. 3, pages 52-57), comments:
One particularly noteworthy finding of this study is that only one patient in the trial developed MAC strains that were resistant to clarithromycin. Other investigators have reported substantially higher levels of clarithromycin resistance to MAC in patients who received this drug as prophylactic monotherapy. (In a small pilot study, the incidence of resistance, when clarithromycin was used as sole prophylaxis against recurrent MAC, was 40% among patients with breakthrough infections.) In the study by Chaisson et al., participants received a combination of drugs from the start. The authors speculate that the addition of ethambutol to the regimen may have prevented the emergence of clarithromycin-resistant strains of MAC.
Repeated mutation may eventually render HIV ineffective
Recent in vitro studies involving two experimental protease inhibitors shed new light on the phenomenon of viral resistance to these drugs. Investigators grew laboratory and clinical strains of HIV in the presence of these potent new protease inhibitors in order to select out strains that were resistant to the two investigational drugs. These resistant strains were subsequently analyzed in several ways to assess their viability.
Croteau and coworkers used protease enzymes extracted from the mutant HIV strains they had developed to create HIV clones that were highly resistant to these new protease inhibitors. The catalytic efficiency of these mutant viral strains was found to be significantly lower than that of unaltered versions of the HIV protease enzyme. This may indicate that HIV does not always adapt to selective pressures as successfully as conventional wisdom has held that it does.
As importantly, these mutant strains of HIV appeared to be less virulent than wild-type virus. In the test tube, viral strains with a single mutation did not manifest impaired growth properties, but strains that exhibited between four and seven mutations at the active protease enzyme site propagated at a lower rate. So substantial was this growth differential that when the highly mutant clones were mixed with wild-type viral strains in cell cultures, the mutants completely disappeared.
These findings lend support to a report, published by Kaplan et al. in 1993, which suggested that HIV might actually lose its ability to infect CD4 cells if it mutated often enough in response to antiretroviral assault. Kaplan and coworkers demonstrated that subtle defects in the protease gene -- defects that resulted from incubating the virus with protease inhibitors at the concentrations achieved in treated patients -- dramatically altered the ability of these clones to reproduce in host cells. This team noted that the altered morphology they observed in these mutant viral strains was associated with reduced infectivity.
Croteau G, Doyon L, Thibeault D, McKercher G, Pilote L, Lamarre D. Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J Virol 1997; 71 (2): 1089-96.
Kaplan AH, Zack JA, Knigge M, Paul D, Kempf DJ, Norbeck DW, Swanstrom R. Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles. J Virol 1993; 67 (7): 4050-5.
Dr. James O. Kahn, one of the authors of "The Problem of Protease Resistance," comments:
The findings of Croteau et al. suggest that protease inhibitors may retard viral growth in an unexpected way. We know that this class of drugs interferes with viral reproduction at the last stage of the virion's life cycle -- by disabling a gene that is critical to viral reproduction. What the in vitro data collected by these investigators indicate is that protease inhibitors may also provoke the emergence of mutant versions of the virus that are "unfit" for survival. This phenomenon would explain the continuing clinical stability of patients even after they develop drug-resistant strains of HIV -- and it would be an argument for continuing patients on therapy after resistance does develop.
Two-drug combination overcomes chief limitation of saquinavir, its low bioavailability
The protease inhibitor saquinavir has the lowest bioavailability of the four F.D.A.-approved protease inhibitors, and research is currently underway to correct this limitation. In the meantime, there is mounting evidence that combining saquinavir with another approved protease inhibitor, ritonavir, may partially ameliorate this problem.
Saquinavir and ritonavir are both metabolized in the liver, mostly by enzymes that make up the cytochrome p450 system. Since the level of cytochrome p450 enzymes in the liver is limited, it is possible to saturate all of the active sites on those enzymes. The theory behind saquinavir-ritonavir combination therapy is that taking these two protease inhibitors concurrently will saturate enough active sites to increase the amount of time it takes the body to eliminate the drugs -- and this, in turn, will keep more active, unmetabolized drug in the bloodstream.
This is apparently what happens, at least in the test tube. Kempf et al. exposed human live cells to combinations of ritonavir and the following drugs: saquinavir, indinavir, and nelfinavir. The investigators noted that the metabolism of each drug was decreased in the presence of ritonavir, resulting in higher concentrations of the second drug over a longer period of time. Interestingly enough, the level of ritonavir did not change when it was administered in these combination regimens.
This study also included a clinical component: eight volunteers were given a single dose of saquinavir (600 mg) with or without ritonavir (200 mg). In two subjects who were deemed "typical", the peak concentration of saquinavir rose from .1g/mL to .3g/mL when the drug was coadministered with ritonavir -- a substantial improvement in peak levels. Furthermore, circulating levels of saquinavir were detected 40 hours after the two-drug combination was administered -- a substantial improvement in the drug's half life. One implication of these observations is that the bioavailability of protease inhibitors is limited by metabolism rather than absorption from the gut.
Kempf DJ, Marsh KC, Kumar G, Rodrigues D, Denissen JF, McDonald E, et al. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents and Chemother 1997; 41 (3): 654-60.
Dr. Harold A. Kessler, the author of "The Next Generation of Antiretroviral Agents" and a member of the editorial advisory board of HIV Newsline, comments:
The work of Kempf et al. suggests several ways in which we may be able to enhance the clinical utility of the protease inhibitors that are currently available to us. First, the data collected by these researchers reinforce the conviction -- widely held among experts in the field, but supported by very little clinical evidence -- that certain protease inhibitors, taken concurrently, have synergistic activity against HIV. Second, the evidence that saturation of the active sites on cytochrome p450 enzymes leads to higher plasma concentrations of active drug has important clinical implications. We know that drug-resistant strains of HIV develop when plasma levels of those drugs fall below therapeutic levels. If combination therapy leads of higher concentrations and long half-life, this could thwart the emergence of resistant strains.
It is also possible that combining protease inhibitors might permit less frequent dosing, which would doubtless enhance compliance. The authors observe that ritonavir and saquinavir make a particularly attractive combination because of the limited cross- resistance seen between these drugs.
First compound in its class shows strong in vitro antiretroviral activity
Preliminary data suggest that disulfide-containing macrolides might nicely complement currently available antiretrovirals agents. The first of these compounds, SRR-SB3, is distinct from other antiretroviral agents in that it does not specifically inhibit reverse transcriptase, protease, or any other viral enzyme. Furthermore, it has no effects on syncytia formation and does not block the binding of HIV to target cells. Instead, SRR-SB3 forms a complex that has a chemical binding motif known as a "zinc finger." Zinc fingers are a biochemical gripping mechanism that chemicals use to attach themselves to chosen molecules.
HIV uses these finger-like projections to bind zinc and to accomplish certain other biological activities. SRR-SB3 dislodges zinc from the pocket in which the virus normally holds it, thereby interfering with the assembly and disassembly of HIV's nucleocapsid proteins.
It is believed that the observed antiretroviral activity of SRR-SB3 is a function of the macrolide's ability to hamper late-stage viral replication, a theory supported by the fact that the drug does not inhibit the level of proviral DNA in cell lines exposed to it. Inhibition of proviral DNA would imply antiretroviral action at an earlier stage of HIV infection.
This purported mechanism of action is consistent with laboratory findings that this drug thwarts the virus in chronically infected cells (whereas most antiretroviral agents are effective only in acutely infected cells). Another quality that makes SRR-SB3 an attractive adjuvant therapy is that it demonstrates activity against strains of HIV that are resistant to nucleoside analogs, protease inhibitors, and/or non-nucleoside reverse transcriptase inhibitors.
The authors speculate that SRR-SB3 itself may be immune to the development of viral resistance, since the zinc finger motif it targets is highly conserved among viral strains. There was also some suggestion that this macrolide may have additive and/or synergistic effects when combined with nucleoside analogs.
Although SRR-SB3 did cause some cell toxicity at high doses, the authors point out that studies in mice did not reveal adverse effects. They also postulate that the drug does not have a global effect on zinc finger binding in normal cells, only in those that harbor HIV. Look for this drug and others in its class to undergo further development.
Witvrouw, M, Balzarini J, Pannecouque C, Jhaumeerl-Laulloo S, Este JA, Schols D et al. SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Antimicrob Agents Chemother 1997; 41 (2): 262-8.
Another entrant in a rapidly expanding field
The class of antiretroviral agents known as non-nucleoside reverse transcriptase inhibitors is extremely active against the target enzyme but is vulnerable to the rapid development of resistance. Two NNRTIs have been approved this year: nevirapine and delavirdine. If resistance to these drugs becomes clinically significant -- a development that seems likely, given our clinical experience with these drugs and with antiretroviral agents in general -- alternatives will be needed. The potential candidates include four novel NNRTIs, now in the early stages of development, that show considerable activity against strains of HIV that are resistant to nevirapine and delavirdine.
Oxathiin carboxanilide derivatives have been identified as powerful antiretroviral agents. They target reverse transcriptase, but use a different mechanism of inhibition than the nucleoside analogs. As might be expected of RT inhibitors, they are active in cells that are acutely infected. The specificity of oxathiin carboxanilide derivatives for HIV-1 is reflected in their inability to inhibit HIV-2 or simian immunodeficiency virus. The four candidate drugs are referred to as UC10, UC40, UC781 and UC82.
The hallmark of these drugs is their potent activity against HIV strains that have developed resistance to other NNRTIs. This characteristic may portend a role for these drugs in combination with nevirapine and delavirdine, since these second-generation NNRTIs may prove capable of inhibiting the emergence of resistant strains.
These investigational drugs also demonstrate considerable versatility in terms of the cellular environments in which they can function. Their antiviral effects were duplicated in B lymphocytes, monocytes, and macrophages as well as T lymphocytes. Importantly, these UC derivatives are active against HIV found in the peripheral blood of HIV-infected persons, meaning that clinical as well as laboratory strains of HIV are susceptible to these new drugs. As further evidence of their potential clinical utility in combination antiretroviral regimens, these UC derivatives demonstrated significant synergism when mixed with ZDV.
Buckheit RW, Snow MF, Fliakas-Boltz v, Kinjerski TL, Russell JD, Pallansch LA et a. Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates. Antimicrob Agents Chemother 1997; 41 (4): 831-7.
Dr. Harold A. Kessler, the author of "The Next Generation of Antiretroviral Agents" and a member of the editorial advisory board of HIV Newsline, comments:
One of these candidate drugs has emerged as a particularly promising antiretroviral agent. UC781 had high activity against HIV in vitro and has been shown to completely inhibit viral isolates that have become resistant to other reverse transcriptase inhibitors, except when the mutant strains had developed multiple amino acid substitutions. These effects were seen at drug concentrations that were non-cytotoxic. In fact, Buckheit et al. did not observe any toxic effects to cells in their in vitro studies, a finding consistent with the drug's extremely specific attraction for the RT enzyme.
In addition, UC781 has a wide therapeutic index, which means that the effective therapeutic dose is much lower than the observed toxic dose. For obvious reasons, clinicians feel more comfortable prescribing new drugs to their patients when the therapeutic index of those drugs is wide, knowing that there is a reduced likelihood of adverse events.
Some level of resistance to UC derivatives was seen by these investigators. Interestingly enough, these resistant strains proved susceptible to other NNRTIs, suggesting a potentially reciprocal therapeutic combination.
Soft gelatin capsule has up to nine times the bioavailability of old formulation
Hoffmann-LaRoche, maker of saquinavir (Invirase®), has applied to the F.D.A. for permission to market a new formulation of their protease inhibitor. This version, which comes in a soft gelatin capsule, has eight or nine times the bioavailability of the old formulation when given at the doses used in clinical trials. Low bioavailability has been the chief limitation of saquinavir, which has an acceptable side effects profile even at doses substantially higher than the standard therapeutic dose. Ongoing clinical trials are testing this new formulation of saquinavir in combination with nucleoside analogs, NNRTIs, and other protease inhibitors (see "Enhancing saquinavir levels with ritonavir").
Back to the June 1997 HIV Newsline contents page.
This article was provided by San Francisco General Hospital. It is a part of the publication HIV Newsline.


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In November 2012, manager Andre Villas-Boas handed a Premier League debut to young midfielder Tom Carroll.
The 21-year-old academy graduate went on to make a further six appearances in the league, including in the north London derby against Arsenal.
Carroll endeared himself to the Tottenham faithful with his energetic, enthusiastic cameo performances; with many feeling he is ready to be given more chances in the first team this coming season.
The England under-21 international has shown the White Hart Lane crowd that he possesses fantastic vision and a wonderful range of passing not unlike that of his former teammate, Luka Modric.
Whilst the Croat isn't exactly the most popular man amongst Spurs supporters for the way in which he left the club for Real Madrid, most would admit that he was a pivotal factor in Harry Redknapp's successful reign as manager.
If Tom Carroll can emulate some of the success Modric had at Tottenham he can become a club great.
Carroll enjoyed his first taste of regular football when he joined League 1 side Leyton Orient in January 2011 on a loan deal for the remainder of the 2010-11 campaign.
This experience served him well and in the next season, he made his Tottenham debut, featuring in the Europa League and Carling Cup under Redknapp, before eventually joining up with Nigel Clough at Derby for another loan deal.
One worrying thing for Carroll would be the amount of midfielder's Tottenham possess, with Mousa Dembele, Sandro, Scott Parker, Tom Huddlestone, Lewis Holtby and new signing Paulinho to compete with.
With the array of talent Villas-Boas has to choose from in the midfield department, Carroll could find his opportunities limited, which would surely halt his progress. But with Tom Huddlestone and Scott Parker linked with moves away and with time on his side, Carroll could yet earn the starts his potential deserves.
Emulating the success of Luka Modric will be a tall order for the Watford-born 21-year-old and this coming season could be vital in his development.
But if Tottenham can watch him fulfil his undoubted potential, it could save them millions of pounds in having to keep buying new midfielders. Only time will tell whether this promising youngster will make the grade at White Hart Lane.
Write for GiveMeSport! Sign-up to the GMS Writing Academy here: https://bit.ly/12evFlH
DISCLAIMER: This article has been written by a member of the GiveMeSport Writing Academy and does not represent the views of GiveMeSport.com or SportsNewMedia. The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeSport.com and SportsNewMedia do not take any responsibility for the content of its contributors.


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'Before Sunrise' (1995)
Not just one of my favorite love stories but one of my all-time favorite movies, "Before Sunrise" chronicles the one-night walk-and-talk between American guy Jesse (Ethan Hawke) and French gal Celine (Julie Delpy). What's more romantic than a chance meeting on a train that leads to not just an unforgettable evening but two sequels (the 2004 sequel "Before Sunset" and forthcoming "Before Midnight") that, without sugar-coating the challenges of time and distance, reiterate how much this couple's time together in Vienna meant in the long term? -- Matt Pais
Copyright © 2019, RedEye Chicago


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Happy 60th Birthday Female Womens Year of Birth Greetings Card - Born 1957 Facts
Year of Birth Facts Birthday Card
Year: 1957 (suitable for 60th birthdays in 2017)
Version: Womens / Female
Bursting with interesting facts, this card takes a look back 60 years to see what was happening in 1957.
- Comes with matching purple envelope
- Left blank inside for you to handwrite your own personal message
- Professionally printed in Yorkshire on high quality FSC certified card
- A5 (210mm x 148mm) in size, opens from the side.
Posted 1st class, safely packed in a clear cello bag and hard backed envelope.
--- Please note: Sorry, but I am unfortunately unable personalise these cards ---
More milestone birthday years and variations available in my shop
All card designs and photographs © Copyright Knitally, Alison Foster 2016
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You have 14 days, from receipt, to notify the seller if you wish to cancel your order or exchange an item.
Unless faulty, the following types of items are non-refundable: items that are personalised, bespoke or made-to-order to your specific requirements; items which deteriorate quickly (e.g. food), personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken.


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Tsavo East National Park
Tsavo is in Kenya close to the city of Mombasa.
Tsavo National Park was established on 1st April, 1948 with an area of 21,812 Km2 It is the largest Park in Kenya. In May 1948 Tsavo National Park was divided into East and West for administrative purposes. The two Parks are divided by Nairobi–Mombasa railway /road.
The Waliangulu and Kamba tribes used it as a hunting ground prior to gazettement. Dr. Krapf journeyed on foot through this area in 1848 crossing the Tsavo river on his way to Kitui – first European to see Mt. Kenya. Construction of the railway reached Tsavo river in 1898. During the construction of the bridge two lions terrorized the workers, killing over 130 people before being killed by Col. Patterson. Patterson recounted the story in his book The Maneaters of Tsavo which became the major motion picture The Ghost and the Darkness (1997). During the World War I (1914-1918) British forces built fortresses along Tsavo river to counter threats from invading German forces from Tanganyika (present Tanzania) – whose intention was to blow up the Tsavo river bridge that was vital to British Communication. Captain Lugards a European explorer passed through the area on his way to Uganda and had a drop over at the Lugards falls area.
Flora and fauna[edit]
Get in[edit]
Smartcard is needed to enter. Smarcards can be obtained and loaded at Voi gate.
How does the system work? P.O.I. (Point of Issue): The visitor will be issued with the SmartCard at the POI and their details put on the card. Proof of identity is required for a citizen and resident cards. POIs are located at Nairobi Park Main Gate, Lake Nakuru Park Main Gate, Tsavo East Main Gate (Voi), and Mombasa KWS Offices.
P. O. S. (Point of Sale): A sales office where visitors pay money to be loaded on the card. POS's are located in Nairobi Park Main Gate, Lake Nakuru Park Main Gate, Tsavo East Park Main Gate (Voi), Aberdare Hqs., Mombasa KWS Offices, Malindi Marine Park, Amboseli Park Meshanani Gate, Tsavo West Mtito Andei Gate.
P.O.A. (Point of Access): This is a Park entry point (gates). A visitor will produce the card and the appropriate amount deducted depending on the visitor category.
Source : K.W.S. park tariffs Adult resident - 500 Kshs Children resident - 200 Kshs Adult non resident - 23 US Children non resident - 10 US
Less than 6 seat - 200 Kshs 6 to 12 seats - 500 Kshs
Get around[edit]
It is often best to hire a tour operator to take you to all the sites. It is also recommended that you book early because availability can be a problem at the last minute.
Tour operators: Big 6 Tours - Specializing in Kenyan Safaris www.big6tours.com [email protected]
Lofty Tours, Monica Solanki - tour director, Tel Office 220241, email: [email protected], web site: www.lofty-tours.de
Bush and Events Africa Email: [email protected] www.bushandevents.com
See[edit][add listing]
Tsavo East is a very popular Park as is indicated by the high number of tourists. Some of the attractive scenic features include:
Do[edit][add listing]
Buy[edit][add listing]
Eat[edit][add listing]
Drink[edit][add listing]
Sleep[edit][add listing]
One of the most scenic lodges in Tsavo is the Voi Lodge.
Perched on the top of a cliff-faced hill, Voi Safari Lodge is uniquely designed to be a hinge like structure overlooking Kenya's Tsavo East plains extending as far as the undulating terrain of the Yatta Plateaus. This vantage positioning of the lodge has made it a stop over for many safari adventures, nature lovers and holiday makers who are assured of sampling Kenya's wildlife attractions that continuously beat a track to the three water holes sunk by the lodge below the cliff.
During the dry season the waterholes are the convergence of a lot of wild animals moving almost in a trance as if urged on by some kind of telepathic communication, the sight is just fantastic. The location evokes a romantic inspiration that once moved a visiting British poet who now incorporated his experience at the lodge in most of his poems, to describe it as sample of wonder that is better than a dream.
Stay safe[edit]
Get out[edit]


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The Manhattan Leather Changing Bag is now in stock.
Get a taste for Pitterpac's effortless style with the Manhattan leather changing bag. The ever fashionable coral hue is a bright, yet sophisticated companion for any summer outfit, whilst the satchel shape and detachable tassels bring a high-fashion finish to the Manhattan leather changing bag. The innovative interior design allows you to stay organised for any trip out with baby or toddler, whilst this bold accessory becomes the focal point of your everyday look.
The spacious style of The Manhattan houses plenty of compartments within its wipe-clean, water resistant interior, easily holding all of your mother and baby essentials. Boasting two large elasticated compartments for bulky items and two smaller elasticated pockets for bottles and sippy cups, the Manhattan is carefully crafted to ensure all of you and your baby's belongings are kept secure and organised.
Packed full of additional invaluable features, such as a Smartphone pocket and zip closed pockets both inside and out for valuable items, the Manhattan can handle anything life with a baby can throw at it. With multiple options, you can also choose to carry your changing bag by the top handles, or take advantage of the additional adjustable shoulder strap to wear across body or over the bars of most prams and pushchairs.
Adapt your Manhattan leather changing bag to suit your changing needs; by simply removing the Pitterpac changing mat organiser you will be left with the perfect handbag, travel bag or accessory for your work wear.
Included with you Pitterpac Leather Changing bag:
Please note that Outlet stock is last season designs, and the accessories that accompany will be slightly different in colour to the lining of the bag.
Designed by a mother who knows the demands of life with a baby and toddler, the inside of every Pitterpac luxury changing bag has been built to make your life easier. Considering the range of items parents have to carry on the go, Pitterpac have included a variety of pockets to ensure everything has a place.
Two large elasticated pockets allow you to store a multitude of items, such as nappies, snacks, wipes, muslin cloths, spare clothes, comforters or even your camera and sunglasses. An extra interior zip closed pocket is designed to securely carry personal items such as your keys, makeup or even a spare change of clothes for baby.
Also featured are two smaller elasticated pockets, perfectly sized to carry baby bottles and toddler beakers, and a handy mobile phone pocket, sized to carry most of the leading smartphone handsets.
Internally, all Pitterpac baby bags are wipe-clean and water resistant. The lining of our changing bags are also a sumptuous cream to prevent a 'black hole' effect, allowing you to locate items quickly and easily on the go.


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Travel times could be more than three times longer over the holiday week
AAA projects 50.9 million Americans will journey 50 miles or more away from home this Thanksgiving, a 3.3 percent increase over last year. The 2017 holiday weekend will see the highest Thanksgiving travel volume since 2005 with 1.6 million more people taking to the nation's roads, skies, rails and waterways compared with last year.
"Thanksgiving kicks off the start of a busy holiday season, and more thankful Americans will travel to spend time with friends and family this year," said Mary Maguire, AAA Northeast Director of Public and Legislative Affairs. "A strong economy and labor market are generating rising incomes and higher consumer confidence, fueling a strong year for the travel industry, which will continue into the holiday season."
The Thanksgiving holiday travel period is defined as Wednesday to Sunday, November 22-26.
By the numbers: 2017 Thanksgiving travel forecastRoad trip ready: 89 percent of all travelers – 45.5 million – are planning a Thanksgiving road trip, an increase of 3.2 percent over last year. Cheaper airfare: Consumers will pay the cheapest average airfare since 2013. Fuller skies: The largest growth in holiday travel is by air travel, at five percent, with 3.95 million travelers. Alternate travel: Travel by trains and other modes (including buses and cruises) is expected to increase 1.1 percent to 1.48 million travelers. Locally busy: More than 1.1 million Massachusetts residents are among those traveling, over 975,000 of them by car.
Travelers beware and advised: Traffic hotspots, best and worst times to hit the road
Based on historical and recent travel trends for the holiday week, INRIX, in collaboration with AAA, predicts drivers will experience the greatest amount of congestion during the early evening – as early as Tuesday of Thanksgiving week - as commuters mix with holiday travelers.
"Thanksgiving has historically been one of the busiest holidays for road trips, and this year we could see record-level travel delays," says Bob Pishue, transportation analyst at INRIX. "Knowing when and where congestion will build can help drivers avoid the stress of sitting in traffic."
Worst time to travel
Metro Area Worst Day for Travel Worst Time for Travel Delay Multiplier
Chicago, IL Tuesday 5:00 - 6:00 PM 3x
San Francisco, CA Tuesday 4:00 - 5:45 PM 2.5X
Los Angeles, CA Tuesday 3:15 - 6:00 PM 2.5x
Boston, MA Tuesday 5:15 - 7:15 PM 2.5x
New York, NY Tuesday 5:30 - 6:30 PM 2x
Washington, DC Tuesday 4:45 - 6:00 PM 2x
Seattle, WA Tuesday 3:45 - 5:30 PM 2x
Atlanta, GA Wednesday 3:00 - 5:15 PM 2x
Houston, TX Wednesday 5:45 - 7:00 PM 1x
Detroit, MI Tuesday 3:00 - 5:30 PM 1x
The worst traffic hotspot during Thanksgiving week in each of the 10 most congested cities in the U.S. are:
Top traffic hotspot in America's most congested cities
Rank City Location
1 Los Angeles, CA I-5 S at Valley View Ave
2 New York, NY I-495 E at NY-106/NY-107
3 San Francisco, CA I-80 E at Pinole Valley Rd
4 Atlanta, GA I-75 N at Chastain Rd
5 Miami, FL I-95 N at Congress Ave
6 Washington, DC I-95 S at US-17/US-1
7 Dallas, TX US-75 S at I-45/I-3
8 Boston, MA I-90 W at I-84/US-20
9 Chicago, IL I-90 W at I-190
10 Seattle, WA I-405 S at WA-167
Top 10 Thanksgiving destinations
Many travelers will seek theme-park and warm-weather destinations this Thanksgiving. Both Orlando, Florida, and Anaheim, California, top this year's top 10 holiday destinations based on AAA.com bookings. Compared to previous years, New York City, Las Vegas and San Francisco are gaining popularity as holiday spots.
1. Orlando, Florida
2. Anaheim, California
3. New York City, New York
4. Honolulu, Hawaii
5. Las Vegas, Nevada
6. Punta Cana, Dominican Republic
7. Cancun, Mexico
8. San Francisco, California
9. Kahului, Maui, Hawaii
10. Fort Lauderdale, Florida
Lockouts, flat tires to strand 330,000 motorists this Thanksgiving
AAA expects to rescue more than 330,000 motorists this Thanksgiving weekend, with the primary reasons being lockouts, flat tires and battery-related issues. AAA recommends motorists have their vehicles inspected by a trusted repair shop, such as one of the more than 7,000 AAA Approved Auto Repair facilities across North America. Members can download the AAA Mobile app, visit AAA.com or call 1-800-AAA-HELP to request roadside assistance.
Download the AAA Mobile app before a Thanksgiving getaway
Before setting out for the long Thanksgiving weekend, download the free AAA Mobile app for iPhone, iPad and Android. Travelers can use the app to map a route, find the lowest gas prices, access exclusive member discounts, make travel arrangements, request AAA roadside assistance, find AAA Approved Auto Repair facilities and more. Learn more at AAA.com/mobile.
About the AAA travel forecast:
AAA's projections are based on economic forecasting and research by IHS Markit. The London-based business information provider teamed with AAA in 2009 to jointly analyze travel trends during major holidays. AAA has been reporting on holiday travel trends for more than two decades.
AAA Northeast is a not-for-profit auto club with 62 offices in Rhode Island, Massachusetts, Connecticut, New Hampshire, New Jersey and New York providing more than 5.2 million local AAA members with travel, insurance, finance, and auto-related services.


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Selecting your vehicle's make, model, and year allows us to display only parts and items specific to your car's model and year.
Part# JKOPG
2 Reviews
OPGI Price: $95.00
Part Type: (A) Aftermarket product, usually an enhancement product
Years: 1959-1977
Sold As: EACH
Heavy poly-cotton blend, nylon-lined Dickies jacket with OPGI patch front and back. They are available in black and come in sizes from medium-4XL.


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Tuxedo, Groom Tuxedo Ideas New Beige Wedding Suits Men Notched Lapel Pieces Men Tuxedos New Beige Wedding Suits For Men Notched Lapel: Awesome Groom Tuxedo Details
Published at August 11th, 2016 06:02:59 AM by admin
Tabbed as Suit Rental Men's Wearhouse area of interest along with Cheap Groom Tuxedos discussion or Tuxedos Online 2016 area of interest or groom tuxedo or suit topic and groom tuxedo prices discussion or groom tuxedo rental object with Tuxedo, So don't forget to check out the main article in Awesome Groom Tuxedo Details
Since this is your big day, you should never let anyone steal the attention from you and the bride. With a simple trick, you can improve the style and design of your groom's attire. The first trick that you can apply on the groom's attire is by placing a large boutonniere. Pick the one in fresh flower which comes in similar flower that the bride takes in her hands. It will be great if the groom tuxedo comes with a shocking colored flower to draw the attention of the guests. They will find out that you are not the best man but the groom by wearing the boutonniere.
Evening wedding should reflect the glamorous feeling. The night time brings a special appeal for the guests. You need to make the wedding decor fabulous even though the light is dim. It definitely can bring the romantic style on your wedding occasion. You can enjoy a great sophistication and glamour. Don't forget to entertain the […]
If you want to launch a free spirit on the wedding occasion, you have to wear bohemian wedding gowns. The bohemian wedding function is totally different with the common wedding occasion. This style is very unique since it makes you blend with nature. The bohemian wedding occasion is always on the top position when the […]
Groom tuxedo always comes in similar design with the groomsmen's tuxedo. If your husband to be wants to look stand out from the group of the groomsmen, you need to choose different style for the groom's attire. Even though the traditional attire for the groom is always linked with a black tuxedo, a black bow […]
The decoration on your wedding stage should be picked based on the themes. The wedding stage is needed since it can give you a wonderful backdrop. You need to decide the theme based on the budget too. If you only have limited budget, there is no need to pick the regal and luxury theme. It […]
Unique wedding idea decoration can be inspired form the season. The people always want to have a unique style on their wedding. It is your one in a life time experience. You need to make it special and wonderful. Sometimes people do not know what to do with their wedding. Months before the wedding celebration, […]
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Greater Central Ohio Best-One Tire & Service Stores have been the choice of trucking and fleet operators in the central Ohio area for years, thanks in large part to our commitment to superior service and customer satisfaction. Our technicians are experts at working with commercial tires. The trained professionals and state-of-the-art facilities at Greater Central Ohio Best-One Tire & Service Stores are dedicated to the purpose of providing you with the best selection of top quality commercial tires and services at the best possible value to our commercial tire customers.
Did you know an out-of-balance tire will cause a vehicle to vibrate at certain speeds, usually between 50 and 70 miles per hour? A tire is out of balance when one section of the tire is heavier than the others. One ounce of imbalance on a front tire is enough to cause a noticeable vibration in the steering wheel at about 60 miles per hour. Greater Central Ohio Best-One Tire & Service Stores use the finest computer wheel balancers to ensure a smooth ride and excellent performance. Our technicians will mount the tire on a balancing machine which spins the wheel to locate the heavier part. They then compensate for the heavy part by attaching a lead weight on the opposite side. Our customers are pleased with how smooth their trucks drive after balancing all four wheels.
Routine wheel alignments are the most effective way to control tire costs and in turn, impact fuel costs as well. We recommend a minimum of two to three alignments per year or every 50,000 to 60,000 miles as part of the average vehicle's preventive maintenance program.
Our long-standing history of providing reliable, professional commercial tire and service has made us a leader in the fleet service industry. We welcome the opportunity to service your commercial fleet. Give us a call today or contact us online for a quote.
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SuicideGirl of the Day – Asbury [PICTURES]
Age: 24
Occupation: Dreamer. Hopeless Romantic. Painter. Photographer. Student.
Makes me happy: Art, black & white photographs, cheese, hoodies, John Cusack.
SuicideGirls is a community that celebrates alternative beauty and alternative culture from all over the world. Since 2001, tens of thousands of models have submitted millions of photos to their website hoping to become SuicideGirls.


text: General Financial Aid Information The 2016-17 FAFSA applies to the Summer 2016, Fall 2016, and Spring 2017 semesters. All financial aid is based on fund availability and not necessarily based on financial need. To ensure that you receive maximum funding, continuing students should submit the FAFSA by April 15, 2016. New students should complete the FAFSA as early as possible before starting classes. You need to reapply for financial aid every year! Watch Video: FAFSA Tutorial Estimate Your Eligibility The federal government has implemented the FAFSA4caster, which will provide you with an early estimate of eligibility for federal student aid. This website provides you with an opportunity to enter your information, receive an estimate of financial aid awards and then import your information into the federal application, the Free Application for Federal Student Aid (FAFSA). Visit www.FAFSA4caster.ed.gov to learn more.


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Welcome to Chowhound Starship Mellencamp.
Bob(TM) has added features that will make these boards much more convenient to use. We'll let most of them be pleasant surprises, but there are two things you need to know:
1. After composing a message and clicking the "post this message" button, you're shown a new window offering you a chance to edit, cancel, or post. If you don't click one of the "post" buttons at this point, your message WILL NOT POST! So don't forget to wait for this intermediary window (it takes some getting used to, especially since it looks like the old "thanks for posting!" window which we're all used to ignoring!)
2. We've added a much-needed feature: you can now change a discussion's subject title when replying. Lots of new people will be showing up soon, and we're counting on you regulars to set a good example with this new feature. Please read carefully:
It's always best to start a totally new thread when a discussion's subject drifts. So only reply with a new subject title if you think it's important to keep your reply tied linked the message it's replying to (oh, and if the person you're replying to has drifted badly without changing title, please change title in YOUR reply...better late than never!).
Don't change titles for minor drift...titles don't have to match EXACTLY. And please avoid frivolous subject changes...we don't want to splinter discussion by having nearly every reply sport a new title.
Once again, please try, whenever possible, to start new threads rather than reply with a changed subject (otherwise ultralong threads will clog our indexes).
Please don't reply here...if you have questions or comments, email us (email@example.com) or leave a message on the "Site Talk" message board--accessed from just beneath the map on our homepage.
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ghost fight
Biggest Disappointments(2013) - Bioshock Infinite - I think this is a great game but after the caliber of the original Bioshock and after experiencing another game with similar plot twists and with a more clever use of Quantum Physics, I foresaw the big twists quite easily and the combat was repetitive generic dribble in certain parts. I was massively hyped for this game but I came out disappointed because it didnt blew my mind like people were saying it would.(Blame zero escape for this)


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New state Rep. Julia C. Hurley, right, has been listening to constituents such as Lynn Farnham since she was elected to the post in November.
Hurley welcomes the public to her first open house from 10 a.m. to 5 p.m. Feb. 5 in her new legislative district office in Harriman's Temperance Building. Light refreshments will be served.
The public is welcome to stop by and express any concerns and ask questions before the Tennessee General Assembly convenes on Feb. 7.
Want to see all there is to see in Tennessee? Check out the new Tennessee Official Vacation Guide.
This year's glossy magazine-style guide features special editorial spotlights on Tennessee's 150th commemoration of the American Civil War, Bright Lights & Big Cities, Main Streets & Small Towns and African-American Influences.
The Discover Tennessee Trails and Byways initiative is covered in a special five-page spread with additional editorial highlights including Dining and Culinary and Tennessee Spirits.
State Rep. Julia Hurley, R-Lenoir City, has been named to the powerful House Transportation and the Government Operations Committee for the 107th General Assembly.
Both committees will play a key role in the upcoming session.
"Ensuring Tennessee's infrastructure is safe and state of the art will assist our state in drawing new business here and creating jobs," Hurley said.
"I am honored to have been named to this committee and I look forward to our work."
State Sen. Ken Yager, R-Harriman, has been appointed chairman of the Senate State and Local Government Committee, a key legislative appointment.
Lt. Gov. Ron Ramsey made the appointment late last week as the State Senate wound up a week of organizational tasks.
"Sen. Yager has vast experience in state and local government matters," said Ramsey of the senator, who served for 24 years as Roane County executive and mayor from 1982-2006.
Many Tennessee museums and attractions will open their doors to Tennesseans for free or reduced admission on Jan. 15 in a cooperative agreement celebrating the inauguration of Gov.-elect Bill Haslam.
Haslam and his wife, Crissy Haslam, are following a tradition started by Gov. Phil Bredesen to raise interest in and celebrate Tennessee's cultural attractions as a feature of the inauguration.
Free admission is being offered on Jan. 15 to the following area attractions:
The Tennessee Department of Environment and Conservation's Division of Solid Waste Management is accepting applications for recycling equipment grants.
Grant applications are due by Oct. 8.
Recycling equipment grants are available to local governments and nonprofit organizations working with local governments.
Grant funds may be used to purchase key pieces of equipment to establish new recycling programs, to improve existing operations or to prepare recyclable materials for transport or sale.
Thousands of issues of old newspapers from across Tennessee will soon be available to the public online, courtesy of the Tennessee State Library and Archives.
Using grant funding provided by the National Endowment for the Humanities as part of the National Digital Newspaper Program, the State Library and Archives will make available dozens of urban and rural newspapers from across the state.
The two-year process of converting those microfilmed documents into digital records will be managed by the University of Tennessee.
To promote sound debt management practices, Tennessee Comptroller Justin P. Wilson is encouraging the state's cities and counties to share what works best for them.
Wilson is asking for comment on a draft statement on debt management.
The draft is based on four guiding principles for Tennessee governmental debt issuers to consider while developing their own policies.
These principles are understanding transactions, explaining to citizens what is being considered, avoiding conflicts of interest and disclosing costs and risks.
Copyright © 2019
The Roane County News is your source for local news, sports, events, and information in Roane County and Kingston, Tennessee, and the surrounding area.


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Tony Ratcliffe - Never Too Old to Try Something New
CIS Professor Tony Ratcliffe decided last year that he wanted to take up a new sport – horseback riding. Why horses? Tony says he was afraid of horses ever since he worked at a horse farm in Berryville, Va., and he realized how big and powerful they were. By taking riding lessons, he hopes to overcome his fear.
He adds, "It's a matter of trying to do new things, and trying something different." He really enjoys the weekly lessons he takes in Singers Glen. "I love it; I'm having a good time. Last week went well; I was feeling more of one with the horse. Bucky (his horse) and I reached an agreement, so we had a smooth ride."
His instructor, Emily Henry, works on the basics, like starting, stopping, and turning. She is also teaching him how to post at the trot. He says, "I really like Emily. She's very good, very patient." Tony started going back to the gym, which keeps him in better shape for riding. He has plans to take a trail ride on the beach during his summer vacation.
He actually enjoyed his first trail ride a few years ago in Griffith Park in Los Angeles. That experience got him thinking about trying to ride more. He also went trail riding in Lost River State Park in West Virginia. Tony thinks one day he may own his own horse, and board it nearby. When his daughter, Jessie, was younger, she begged for a horse, but it didn't fit into their apartment very well.
His goal is to become comfortable with the horse, and be able to handle horse the horse. "I don't see myself as being a high jumper, but maybe I'll take a few low jumps," he laughs. He took a tumble off Bucky a few weeks ago, which helped to lessen his fear of falling.
In addition to riding, Tony enjoys skiing and flower gardening. In fact, he tends to several of his neighbors' gardens.
Tony grew up in Berryville, Va., and attended JMU after earning his associate's degree from Lord Fairfax Community College. He graduated from JMU with a degree in marketing and management, then went on to earn his MBA. He stated teaching in 1986, and has been at JMU either part time or full time since then.
Tony still enjoys teaching, although he says his patience sometimes wears thin. He particularly likes interacting with the students. There is always a long line of students outside his office door, patiently waiting to talk with him.
Tony's future plans include more horseback riding, and maybe a jump from a plane. After all, you're never too old to try new things!
Published: Monday, July 8, 2013
Last Updated: Wednesday, June 8, 2016


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The Tel'tak are a class of Goa'uld light transports. They are the smallest known Goa'uld ships to be equiped with Hyperdrives and are equiped with Ring Transporters for Loading and unloading of Cargo and Personel and are generally unarmed. A Few of them have Cloaking Devices and have been used for inflitration, most notably by the Tok'ra.
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WEST, Texas, April 18 (UPI) -- Emergency responders in West, Texas, searched for survivors Thursday, one day after a fertilizer plant fire and explosions caused scores of casualties.
Texas Attorney General Greg Abbott urged people to stay away from the area as searchers look for survivors and investigators try to determine what caused the disaster, which authorities said killed an undetermined number of people.
Abbott warned unscrupulous business operators against price gouging for necessities.
"Last night was truly a nightmare scenario for that community," Gov. Rick Perry said during a news conference earlier in the day. "This tragedy has most likely hit every family and touched practically everyone in that town."
Texas Department of Public Safety spokesman Jason Reyes said he could confirm there were fatalities as a result of the explosions that shattered the town, but said the number had not been determined. Earlier, West Mayor Tommy Mouska put the number of dead at 40. Officials said about 160 people were injured.
Perry said he requested an emergency declaration from the federal government for McLennan County, where West is located, while lauding first responders and ordinary citizens who rushed to help victims, The Dallas Morning news reported.
"Last night was truly a nightmare scenario for that community," Perry said during a news conference Thursday. "This tragedy has most likely hit every family and touched practically everyone in that town."
The first explosion rocked the West Fertilizer Co. plant Wednesday evening. More explosions occurred several hours later.
Downtown sidewalks were littered with glass from shattered storefront windows. Homes crumbled to rubble, the Morning News said. The brick facade off a 50-unit apartment complex near the West Fertilizer Co. plant was blown away.
Among the missing were three or four members of West's volunteer fire department, including City Secretary Joey Pustejovsky, officials said.
Sgt. W. Patrick Swanton, police spokesman from the nearby Waco Police Department, said during a briefing Thursday authorities have "not gotten to the point of no return."
Houses and buildings destroyed or damaged by the blast were so frail that search teams must move slowly, Swanton said. Rescue workers shore up buildings as much as possible before they're searched.
Once the search is done, a building is marked to indicate no survivors are inside.
"It is a very slow and methodical search," Swanton said.
Meanwhile, state officials began their investigation into what sparked the explosion.
Nim Kidd, chief of the emergency management division with the Texas Department of Public Safety, said fighting a fire involving ammonium nitrate with water is a known hazard, but it was too soon to say what went wrong at the West plant.
President Barack Obama spoke to Perry Thursday morning.
"Today our prayers go out to the people of West, Texas, in the aftermath of last night's deadly explosion at a fertilizer plant," Obama said in a statement issued by the White House. "A tight-knit community has been shaken, and good, hard-working people have lost their lives."
He said his administration has been in close contact with state and local officials in Texas "to make sure there are no unmet needs as search and rescue and response operations continue."
"West is a town that many Texans hold near and dear to their hearts, and as residents continue to respond to this tragedy, they will have the support of the American people," Obama said.
The tragedy was mentioned by several speakers during an interfaith memorial service for Boston Marathon bombing victims.
The Morning News said the Czech ambassador to the United States was reported to be traveling to West, known for its annual Westfest celebrating the city's Czech heritage.
Swanton said the company site would be treated as a crime scene when officers gain full access. The cause of the explosions was unconfirmed.
"We are not indicating that it is a crime, but we don't know," Swanton said. "What that means to us is that until we know that it is an industrial accident, we will work it as a crime scene. ATF [the federal Bureau of Alcohol, Tobacco, Firearms and Explosives] is conducting the main investigation."
Department of Public Safety Trooper D.L. Wilson said the fire was still smoldering at the facility, noting caution was being exercised because of the proximity of flammable chemicals, the Waco Tribune-Herald reported.
Wilson said 50 to 75 houses were damaged and 133 people were evacuated from a nearby nursing home.
He described an apartment complex near the fertilizer plant as "a skeleton."
Wilson described the initial plant blast as "massive -- just like Iraq, just like the Murray Building in Oklahoma City. The same kind of hydrous [ammonia] exploded, so you can imagine what kind of damage we're looking at."
Half of the town of West, population about 2,800, has been evacuated, Wilson said. If the wind direction shifts, the other half may need to be evacuated.
The U.S. Geological Survey registered the blast as a 2.1-magnitude seismic event, ABC News said.


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Last week, the Associated Press reported that the National Intelligence Council is working on a new National Intelligence Estimate that will point the finger at the Chinese government for a multi-year campaign of cyberattacks against American networks. The estimate, according to the wire service, will call for more effective action against Beijing.
The news comes on the heels of a series of revelations that Chinese hackers have been reading e-mails of New York Times reporters as well as attacking the computer systems of the Wall Street Journal and the Washington Post. Reports also suggest the Chinese have hacked Twitter and the Department of Energy.
Hackers in China—associated with government instrumentalities, ministries, state enterprises, the Communist Party, and shadowy associations—have been probing, infecting, stealing from, and disrupting networks around the world in what looks like the largest effort of its kind. Beijing officials, pointing to Chinese government laws against cyber crimes, have repeatedly denied wrongdoing.
President Obama, Defense Secretary Leon Panetta, and senior administration officials have talked with their Chinese counterparts about rampant hacking, but attacks from China nonetheless reportedly spiked in the middle of last year. The apparent failure of dialogue has not stopped the administration from continuing its dialogue with Beijing. Said White House spokeswoman Caitlin Hayden, "We have repeatedly raised our concerns with senior Chinese officials, including in the military, and we will continue to do so."
Unfortunately, talking even more with China's leaders is not going to convince them to stop their highly provocative cyber activities. Why not? This is not just a dollars-and-cents—or, more precisely, yuan-and-fen—decision to obtain valuable intellectual property for nothing. The hacking of the Times, for instance, suggests the Communist Party sees its cyber intrusions as an issue of first importance. The paper, in a front-page article on January 31st, noted that Chinese military hackers were interested only in the Times's reporting last October of the wealth of the family of Premier Wen Jiabao.
The paper's October article, which stated that Wen's family members had accumulated at least $2.7 billion in assets, suggested corruption, and corruption always brings down Chinese dynasties. "Grandpa Wen," as he likes to be called, had been the compassionate face of communism. He was the leader who wept at the scenes of natural disasters, who visited the downtrodden, who called for democracy. Now, however, the Chinese people know, because of the Times's reporting, that he had undoubtedly abused his official position and was no better than other rapacious Beijing leaders.
But I doubt this was just about Premier Wen. Given that China so fiercely attacked the Times for disclosing the extent of the Wen family's accumulation of wealth, it's a good bet that the other leaders wanted to prevent disclosures about themselves. The decision to launch a cyber attack on the Times, therefore, may very well have been a collective decision to circle the wagons.
In the wake of the latest hacking news, China's political leaders only look more desperate. They have morphed from a threat to their own people to a threat to free institutions and free societies. The unprecedented attack on Western media is part of a campaign to intimidate reporters and affect political discourse in America and elsewhere. The West, and democratic countries everywhere, cannot allow the Chinese to succeed.
Hillary Clinton, before stepping down as secretary of state, worried about what could happen when the US responded to Chinese cyber campaigns. "Obviously this can become a very unwelcome and even dangerous tit-for-tat that could be a crescendo of consequences, here at home and around the world, that no one wants to see happen," she said. Clinton is right, of course, but Chinese leaders leave us no choice but to defend ourselves. That's why the administration is about to issue guidelines and policies about the use of the nation's cyberweapons.
For years, Washington delayed taking action against Chinese cyber activities apparently because policymakers thought that if they did, the efforts would undercut attempts to develop cooperative relations with Beijing. Successive administrations harbored the hope that we could talk to the Communist Party and come to some accommodation. These hopes were never realistic and have not changed Chinese behavior, except perhaps to make it worse by suggesting we were not serious.
China's leaders, on the other hand, are serious, and they believe they are entitled to deference. Because they are communists, they feel superior on account of self-pronounced historical destiny. Because of recent economic success, they are arrogant. Because of today's problems, they are insecure. The result is that they now crave control of not only their nation but ours as well.


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* * ½
(High-tech zombie flick)
A zombie movie by any other name is still a zombie movie.
This one goes for high-tech, super special effects, a pseudo-intellectual approach and zombies who run very fast.
Brad Pitt stars as Gerry Lane, a former United Nations investigator who retired to "spend more time with his family," a loving wife (Mireille Enos) and two daughters. They are driving through downtown Philadelphia when they find themselves in the middle of panic in the streets.
Zombies are running amuck, killing everyone in sight. People react by trying to outrun them, but these are not the zombies of "Night of the Living Dead." They don't drag their feet. For some strange reason, people are more concerned about looting the stores than escaping to safety.
His old boss calls him on his cell phone, offering safety for his family if he helps him get to the bottom of this. They are rescued from a rooftop by a helicopter and brought to a command ship in the Atlantic Ocean.
Hence the first moral issue: Only those who can help save the world, and their families, will be saved from the zombies.
The zombies quickly infect people from around the world with a deadly virus. Gerry's job, if he is willing to accept it, is to find the source of the virus and save the world. He has no choice. If he refuses or is killed, his family is taken off the ship. He flies around to North Korea and then to Israel, and then somehow finds his way to "the source." We won't tell you where it is or how he unbelievably gets there. Then the zombie action kicks into full throttle as he fights to save humanity.
The special effects are very good. Pitt is good. The story is stupid.
Rated PG-13, with loads of violence and some pretty disgusting looking zombies.


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Ducati Diavel "Dark"
Parked toDiavel - Don't Call Me a Cruiser
The stance of the Diavel is that of readiness, dominance, and confidence bordering on superiority. Lateral radiators add muscle to its broad "shoulders," which then taper down across the engine and into the belly-fairing with its oil cooler, giving shape to the athlete.
Vehicle Info: 2014 Ducati DIAVEL
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Regional Highlights
Northern Nevada is never short on things to do
Related Websites
Located at the base of the Sierra Crest in the Truckee Meadows, Reno's outdoor recreation possibilities are unlimited. Lake Tahoe is only about a 40-minute drive west from downtown Reno, offering abundant opportunities for skiing, snowboarding, mountain biking, hiking, kayaking, fishing, boating and camping. For those with a penchant for the desert, Pyramid Lake and the Black Rock Desert - home to the annual counter-culture festival, "Burning Man" - are only about an hour's drive to the north.
Reno is host to many fun festivals and exhibits throughout the year.
With over 100 hot air balloons each year, The Great Reno Balloon Race is the largest free hot air ballooning event in the nation! For 27 years locals and visitors have been dazzled by the Glow Shows before the sun wakes up and the awe-inspiring "Hare & Hound" competitions during the day. Starting at the Rancho San Rafael park next to the University of Nevada, Reno campus, the colorful balloons float over Reno as the wind takes them and one can't help but stop and watch.
For more information, visit: the Great Reno Balloon Race.
For six years this festival has been all about outdoor adventure, family fun and community involvement! For four days in May, this festival consists of expositions, competitions, music and other great activities! If you want to see some great whitewater competition or just relax in the grass to some great music, this event is for you!
For more information, visit: the Reno River Festival.
For 23 years, Hot August Nights has given teenagers of the 50s & 60s a chance to relive the glory days and those of a younger generation a window into the past. This fantastic festival is all about classic cars and the birth of Rock'n'Roll!
For more information, visit: Hot August Nights.
Another engine-powered celebration in August, Street Vibrations Motorcycle Festival brings together music, metal and motorcycles. Street Vibrations offers tours, live entertainment, parades, ride-in shows, stunt shows and more. This event is so big, it rocks at several locations throughout the region.
For more information, visit: Street Vibrations.
Artown, noted by the National Endowment for the Arts as one of the most comprehensive festivals in the country, brings the arts to Reno each July with a packed calendar of events. Artown captures the imagination and brings with it a celebration of distinguished artists from around the world, across the country, and those that live in our community all for the sake of cultural diversity and artistic innovation.
The "Wildest, Richest Rodeo in the West," the Reno Rodeo is a 10-day event. The Reno Rodeo is a PRCA (Professional Rodeo Cowboys Association) sanctioned sporting event. Reno Rodeo is a non-profit organization made up over 400 volunteers. Over 140,000 fans will be in attendance for the 4th richest PRCA tour rodeo. The event impacts the Reno/Sparks area economy with $42 million going to hotels, casinos, restaurants and retail. The Reno Rodeo has been nationally televised on CBS Sports, Fox Sports Net, Versus, ESPN, ESPN2 and ESPN Classic.
For more information, visit: Reno Rodeo.


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YSL Faux Cils is one of those consistently complimented products with many, many fans. Coming in a signature flashy gold tube, it certainly makes you feel glamorous…
I didn't realise but I have four tubes in different colours:
Black, Blue, Burgundy and Purple. My favorite is the blue, which really stands out and the warm burgundy:
So onwards with the test. Faux Cils has a very noticable scent which I personally would describe as 'old dressing table'. It used to give me a headache but it grew on me. The colours are very strong and vivid and I find the texture to be quite thick and gloopy. So of course, I had my doubts as to wheather this would work for my kinda lashes.
The truh is it doesn't work brilliantly as a curling mascara (which is what I wanted to find with these tests – the best curling mascara) – but it is the perfect thickening mascara. Thus it works well as a topping mascara on a base, or on a mascara that can hold curl.
Pictures of one coat:
Lashes are nicely separated, and it is the type of mascara you can really build up!
Now to be fair, every mascara I test will be used on its own on clean lashes, curled, with no base. I will only use one coat.
Lengthening – 7/10
Volumising – 9/10
Brush – 7/10 (This brush is not so good on puny lashes.)
Staying Power – 7/10 (Faux Cils does flake on me towards the end of the day).
Smell – 5/10 (It is heavily scented and it gave me headaches at first. I don't see why mascara needs a scent anyway!).
Clump or no Clump? – 8/10 (No clumping, not from a new tube anyway.)
Price – 7/10 (This is expensive! £19)
Packaging – 10/10 (Full on sexy glamour baby. But a bit clunky for carrying around perhaps?)
Ease Of Removal – 9/10 (Easy pease with eye make up remover)
Curl Factor – 5/10 (Does nothing for curls).
Verdict – Overall, 7.5/10 For curling, 5/10.
Anyway, you that produce MUA girls love, Shiseido Lash Base? I decided to try it out with YSL Faux Cils…and it really helped retain curl, but it was pretty clumpy. I think I went overboard with the lash base however. A comb after applying the base and after application would sort it out (BUT, combing lashes can straighten them out).
Pics of my evil eyes – note, I have been tired lately so excuse the evil glances:
See, Shiseido Lash Base makes a big difference in terms of holding curl but needs to be applied sparingly. Otherwise its clump-city.
So there you go, another one down, another twenty mascaras to go!


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2008-10-08 / Front Page
Peter King faces 25-year-old challenger, Graham Long
Rep. Peter King, Long Island's only Republican congressman, is seeking his eighth term in the House of Representatives and the political pundits think the outcome of this election should be no different than the other seven. "Incumbent congressmen rarely lose," said Lawrence Levy, executive director of the National Center for Suburban Studies at Hofstra University.
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An Aquarium Anybody Could Keep
I sort of laughed after reading about the motivation behind this project, a virtual aquarium its designers conceived as an "outlet to the persistent and inexplicable desire to poke at fish in a fish tank".
I don't necessarily share nor condone the designers' urge to poke fish, but as anyone who has visited a pet store, aquarium, or fish market can attest, there does seem to exist a desire to harass our gilled friends as they gently swim on by.
The new age aquarium, Fish Tank, was designed by Manuela Donoso and Crys Moore at NYU's Interactive Telecommunication Program. Glowing like aquatic fireflies, small points of light are projected onto a real bath of water (no fourth wall LCD panels here) with a motion-tracking via HD web cam underneath hooked up to a laptop and Arduino circuit board. The result is a gigantic watery iPad, offering wanna-be ichthyologists the ability to interact and feed schools of digital "fish" by simple taps onto the water's surface (and yes, the option to poke them too).
Via The Verge
(Image/Video: Crys Moore and Manuela Donoso)


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This Flash-based interactive provides access to illustrations, visualizations, videos, and near-real time images of the Sun from a variety of NASA satellites. Learners can access this information to supplement other materials related to the Sun and... (View More) heliophysics. A scale tool with the size of the Earth is also presented with the solar images. (View Less)
Materials Cost: Free
This is an activity about how the Sun can affect the Earth's atmosphere, specifically the ionosphere. Learners will use real data from a Sudden Ionosphere Disturbance Monitor, or SID Monitor, to identify the signatures in the graphed data that can... (View More) be used to determine the times of sunrise and sunset. Although the SID monitors are designed to detect SIDs caused by solar flares, they also detect the normal influence of solar X-rays and UV light during the day as well as cosmic rays at nighttime. There is a distinct shape to a 24-hour SID data graph, with unique shapes, or signatures, of the graph appearing at sunrise and sunset.This activity is part of the Research with Space Weather Monitor Data educators guide. Use of and access to a Stanford Solar Center SID monitor and the internet is encouraged but not required. Locations without a SID monitor can use sample data provided in the educators guide. (View Less)


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Nov. 5, 2005
HANOVER, N.H. - MIT's freshman heavyweight crew finished seventh out of 23 boats at Dartmouth College's Green Monster Invitational. Battling a three-mile course along the Connecticut River, Tech's eight fared remarkably well by securing wins over Harvard, Dartmouth and New Hampshire.
The Scarlet Knights of Rutgers dominated the men's event with two fast eights. Trinity College closed in second with an aggressive attack, and out-stroked all the other teams. Boston University, winners of the Youth 4+ at the Head of the Charles, finished third overall.
Saturday's conditions provided a nice back-drop to the fall season. With temperatures in the low 60's, a light tail stream and sunny skies, the Engineers were poised to continue their success from the Head. Although MIT was passed by Rutgers in the first mile of the course, the Engineers rallied in the second mile to pass two Harvard boats and another eight just before the finish line.
"It was a good showing for our guys," said novice head coach Dan Perkins. "The fall regattas have provided our novices with valuable racing experience."
MIT wraps up its fall slate at home on Nov. 19 in the Foot of the Charles.
MIT Heavyweight 8+
cox: Stephen Young
stroke: Luke Urban
7: Richard Clay
6: Tom Brown
5: James Stenard
4: Kevin Kelley
3: Rane Nolan
2: Chris Baranowski
bow: Andrei Galusca


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Super local
In Victoria the opportunity existed to position a bank as the first choice, a super local preference to the big four, a bank that will never exist in any other state or region with products and services tailored to the people of Melbourne and Victoria – that bank is the Bank of Melbourne.
Designworks created the strategy that enabled the client to build a bank that would be a 'truly local alternative to the big four', a bank focused on what regional customers value – locally managed, community based with caring and approachable staff. A bank built and designed by Melbournians for Melbournians.
The brand forms a modern dynamic take on a trusted and enduring symbol. The shapes reflect the architecture of Melbourne, think the Arts Centre and Federation Square. They also symbolise the elements that together make Melbourne great.
Closely followed by the strategy, Designworks created the brand identity and is now working to apply this across the banks stationery, signage, internal communications, advertising, merchandise and staff engagement.
With the announcement to the press on the 10th March the Bank of Melbourne registered 1000s of mentions on social media and over 20,000 click throughs on digital banners.
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A common example of quenching is observed with the collision of an excited state fluorophore and another (non-fluorescent) molecule in solution, resulting in deactivation of the fluorophore and return to the ground state. In most cases, neither of the molecules is chemically altered in the collisional quenching process. A wide variety of simple elements and compounds behave as collisional quenching agents, including oxygen, halogens, amines, and many electron-deficient organic molecules. Collisional quenching can reveal the presence of localized quencher molecules or moieties, which via diffusion or conformational change, may collide with the fluorophore during the excited state lifetime. The mechanisms for collisional quenching include electron transfer, spin-orbit coupling, and intersystem crossing to the excited triplet state. Other terms that are often utilized interchangeably with collisional quenching are internal conversion and dynamic quenching.
The adherent culture of COS-7 African green monkey kidney fibroblast cells featured in the digital image above was immunofluorescently labeled with primary anti-tubulin mouse monoclonal antibodies followed by goat anti-mouse Fab fragments conjugated to Cy3, targeting microtubules. The cells were simultaneously stained for the cytoskeletal filamentous actin network with Alexa Fluor 488 conjugated to phalloidin, and for DNA with DAPI. Images were recorded in grayscale with a QImaging Retiga Fast-EXi camera system coupled to an Olympus BX-51 microscope equipped with bandpass emission fluorescence filter optical blocks provided by Omega Optical. During the processing stage, individual image channels were pseudocolored with RGB values corresponding to each of the fluorophore emission spectral profiles.
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Reviewed by Lauren P. (age 14)
I would have to say The Help by Kathryn Stockett is definitely one of my favorite books! It lets you into the eyes of the women living in the most racist time in history. Love, sadness, betrayel, comedy and love all come together to form this amazing novel. While reading The Help, I felt like I was in Jackson Mississippi during the 1960's witnessing all the events that took place. I felt nervous when Aibileen and Minny talked about what would happen when the book got published and people found out that they were involved. I also felt exited when Skeeter fell in love. Then sadness when Ms. Phelan becomes ill. The book made me feel all different kinds of emotions. The cool thing about this story was that you were able to see through 3 diferent characters eyes. Each chapter was 1 out of the 3 narrators. Skeeter, Minny, and Aiblileen each tell a bit about there struggles and fears present during the making of the book.
I would recommend this story to high schoolers and up. In this story there were a lot of sad, unfair, and depressing events that would not be appropriate for younger children. Also by the time you reach high school you have learned about the civil rights act so it's interesting to see how people actually felt during the time.