text:
Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00019188
Recruitment Status : Completed
First Posted : March 5, 2007
Last Update Posted : June 20, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill their tumor cells.
PURPOSE: Phase I/II trial to study the effectiveness of interleukin-12 in treating patients with AIDS -related Kaposi's sarcoma.
|Condition or disease
|Epidemic Kaposi's Sarcoma Recurrent Kaposi's Sarcoma
|Drug: interleukin-12
|Phase 1 Phase 2
OBJECTIVES: I. Determine the maximum tolerated dose of interleukin-12 (IL-12) in patients with AIDS-associated Kaposi's sarcoma.
II. Determine the antitumor activity of IL-12 in these patients. III. Determine the effect of IL-12 on angiogenic factors, including basic fibroblast growth factor, vascular endothelial growth factor, and interferon-inducible protein 10 in these patients.
IV. Determine the immunologic and virologic effects of IL-12 in these patients.
PROTOCOL OUTLINE: This is a dose escalation study. Patients receive interleukin-12 (IL-12) subcutaneously twice a week (at least 3 days apart) for 6 months. Patients with stable or better disease continue IL-12 treatment in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of IL-12 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose limiting toxicity. Ten additional patients are treated at the MTD.
Patients are followed at 4 weeks.
Up to 55 patients will be entered over approximately 4.0 years.
|Study Type :
|Interventional (Clinical Trial)
|Primary Purpose:
|Official Title:
|Phase I/II Pilot Study of Interleukin-12 in Patients With AIDS-Associated Kaposi's Sarcoma
|Study Start Date :
|January 1997
|Actual Study Completion Date :
|March 2007
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
--Disease Characteristics-- Histologically proven Kaposi's sarcoma (KS) At least 5 lesions evaluable by noninvasive methods No acutely life threatening lesions that may be responsive to other therapy Actively bleeding or critically located lesions may be excluded at the discretion of the Study Chair or Principal Investigator Asymptomatic pulmonary disease not requiring immediate cytotoxic therapy allowed HIV-associated disease Anti-HIV serum antibodies measured by ELISA and Western blot Stable dose of two or more of the following antiretroviral agents required for 4 weeks prior to study: Lamivudine Didanosine Zidovudine Saquinavir Stavudine Ritonavir Zalcitabine Indinavir Nonnucleoside reverse transcriptase inhibitor Other protease inhibitor Antiretroviral therapy unchanged during study unless medically warranted Patients may switch between antiretroviral agents provided they continue to receive a combination of 2 or more agents --Prior/Concurrent Therapy-- Biologic therapy: At least 6 months since prior interleukin-12 (IL-12) At least 3 weeks since prior interferon therapy At least 2 weeks since prior cytokines or bone marrow stimulating factors (except epoetin alfa) No concurrent cytokines except epoetin alfa or filgrastim (G-CSF) Chemotherapy: At least 3 weeks since prior chemotherapy (at least 6 weeks since prior nitrosoureas or mitomycin) At least 6 months since prior suramin Endocrine therapy: Replacement glucocorticoids allowed At least 2 months since prior systemic glucocorticoids at doses sufficient to affect immune response (e.g., more than 20 mg of prednisone or equivalent for more than 1 week) Radiotherapy: At least 3 weeks since prior radiotherapy Surgery: Not specified Other: See Disease Characteristics At least 3 weeks since prior anti-KS therapy At least 3 weeks since prior local therapy (e.g., intralesional injections) --Patient Characteristics-- Age: 18 and over Performance status: Karnofsky 70-100% Life expectancy: Greater than 3 months Hematopoietic: Absolute neutrophil count at least 750/mm3 Platelet count at least 75,000/mm3 Hemoglobin at least 9.0 g/dL (no transfusion within 1 month prior to entry) Hepatic: Bilirubin no greater than 3.7 mg/dL with direct fraction no greater than 0.2 mg/dL and indirect fraction no greater than 3.5 mg/dL AST no greater than 2.5 times upper limit of normal No history of cirrhosis PT/PTT no greater than 120% of control Renal: Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 60 mL/min Other: No hypersensitivity to IL-12 or other compounds that crossreact with IL-12 No clinically significant autoimmune disease (e.g., systemic lupus erythematosus) or rheumatologic disease No active, gross gastrointestinal bleeding or uncontrolled peptic ulcer disease No inflammatory bowel disease No severe or life threatening infection with bacterial, viral, fungal, protozoal, or parasitic pathogens within 2 weeks of entry No fever of 39 degrees Celsius or higher within 10 days prior to entry unless underlying infection ruled out No second malignancy within 1 year except: Completely resected basal cell carcinoma Carcinoma in situ of the cervix No generalized debilitation or mental incapacitation that would preclude informed consent No abnormality that would score as a grade 3 toxicity other than lymphopenia or direct manifestations of KS Willing to refrain from unprotected sexual contact and other activities that could result in reinfection with HIV Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 2 months after study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00019188
|United States, Maryland
|Medicine Branch
|Bethesda, Maryland, United States, 20892
|Study Chair:
|Robert Yarchoan
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00019188 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|First Posted:
|March 5, 2007 Key Record Dates
|Last Update Posted:
|June 20, 2013
|Last Verified:
|April 2004
Keywords provided by National Cancer Institute (NCI):
AIDS-related malignancies
Kaposi's sarcoma
adult solid tumor
body system/site cancer
epidemic Kaposi's sarcoma
recurrent Kaposi's sarcoma
skin tumor
solid tumor
stage, Kaposi's sarcoma
Additional relevant MeSH terms:
Sarcoma, Kaposi
AIDS-Related Opportunistic Infections
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Neoplasms, Vascular Tissue
Opportunistic Infections
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Parasitic Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Adjuvants, Immunologic
Immunologic Factors
Physiological Effects of Drugs
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents


text:
Vetamur wrote:Sure.. what would be the Bench size on a team with that many? Currently its set for 9.. should be it 11? More?
If I'm remembering right, we start 1 QB, 2 RB, 2 WR, 1 "flex (RB/WR)", 1 TE, 1 PK, 1 ST. Add 2 DL, 2 LB, 2 DB and we're looking at a starting lineup of 15 people. Make the bench 10 and I think we should be good.

subset: commoncrawl


text:
Selecting your vehicle's make, model, and year allows us to display only parts and items specific to your car's model and year.
Part# BR01170
1 Review
OPGI Price: $102.95
Part Type: (R) = Authentic reproduction of the original GM product
Years: 1963
Sold As: SET
2018 Riviera Catalog Page: 98
These are original "Packard Electric" spark plug wires identical to the ones GM used for original equipment. They feature original style molded rubber boots and are date-coded for a complete, factory-fresh appearance.


text:
Posted on September 10, 2012
So how would you like to discuss rubber bands today, mincemeat muffins? Well, so it goes. Those of you who would like to go read the genealogy blog instead may do so. We'll discuss your individual family trees after you leave.
What I wanted to tell you about rubber bands is that I really don't need any. You may donate them if you feel it's essential, but if so, donate them in larger amounts, in boxes or bags of nice, new unused lengths of elastic. It's the used rubber bands that make trouble.
My donors bring me rubber bands in four basic ways. First are the rubber bands that just got mixed in. You were cleaning all the books off the desktop or the bedside table, and there were a few loose rubber bands. This is because there are always loose rubber bands somewhere in the house, and these don't worry me.
Those of you who have been using rubber bands as bookmarks are a dying breed, I hope. You may, of course, use any kind of bookmark you like so long as you either a) finish the book and take the bookmark out so I am never troubled with it b) you use bookmarks which will not deteriorate with age or damage the book, or c) you don't donate the book to me.
Rubber bands, see, dry out with age and become brittle. Somehow, however, at the same time, rubber bands can become sticky and adhere to the page, especially, for some reason, the cover or dust jacket. This leaves me with a dilemma: do I remove the broken bits of rubber band, at the risk of tearing the cover? Or do I leave it there, so that anybody who looks at the book thinks there's a small worm attached to it? This is not what we call a win-win situation.
The same thing happens to books with rubber bands around them. I get these in two basic varieties: there is the book held together with a rubber band and there is the SET of books held together with a rubber band.
I appreciate the help, really I do. If you hadn't thiought to hold those books together I might never have noticed "VOLUME 1" on the cover. And that set of The Lord of the Rings where the first volume came from the movie edition, the second volume from the Tolkien-cover edition, and the third volume from the original dragons and eggplants edition: why, I might have…. Actually, I DID price them separately. My customers don't seem to mind mixed sets, but they prefer to mix their own, and not maintain yours.
And could you just KEEP those books that are going to fall apart if the rubber band is removed? The book must have meant something to you, or you wouldn't have bothered with the rubber band. So keep it. If you're clearing out an estate, the book must have meant a lot to someone who meant something to you. Keep it. Let the next generation throw it away
Oh, you dropped it off because you felt it needed to be thrown away but you couldn't bear to do it yourself? Very well, I can do that for you. Can you what? Have the rubber band back? Get over to that genealogy blog before I snap.
Submitted by moyenage on September 19, 2012 Permalink
Submitted by Newberry Library on September 19, 2012 Permalink


text:
Motorists cautioned about restriping along I-80
01/08/2013 7:53amUDOT officials are warning people who travel on I-80, particularly through Parleys Canyon, to be on the lookout for restriping trucks through the winter.
Man shot by police had BB gun, investigators say
01/08/2013 8:03amMurray police shot and injured a suicidal man who they say threatened an officer early Tuesday morning with what looked like a handgun. It turned out to be a BB gun.
Propane torch used to thaw gutters starts house fire
01/08/2013 8:38amA home caught fire Monday night when the owner tried to thaw his rain gutters with a propane torch.
Boulders leave craters in road after rockslide
01/08/2013 9:47amA rockslide earlier this week in Huntington Canyon has left large craters in state Route 31 at about milepost 27.
Police: Man drove drunk, pointed gun at other drivers
01/08/2013 12:06pmA man who police say was waving a gun at other vehicles while speeding and driving drunk was arrested over the weekend.
Man found dead in trailer park identified
01/08/2013 12:32pmInvestigators were waiting Tuesday for results of an autopsy to determine how a man found dead in a trailer park died.
Utes linebacker dismissed for road rage, assault
01/08/2013 4:38pmUtah coach Kyle Whittingham has kicked a linebacker off the football team after his conviction for knocking a motorist unconscious in a bout of road rage.
Increase in LDS missionaries a boon for local businesses
01/08/2013 6:14pmThe increased numbers of 18- and 19-year-old men and women heading out to serve a mission for The Church of Jesus Christ of Latter-day Saints means business is good for some local companies working hard to serve them.
Jail time for woman who hit estranged husband twice with SUV
01/08/2013 6:45pmA woman who pleaded guilty to driving through a glass door with her SUV to hit her husband nearly six-and-a-half years ago, was sentenced Tuesday to one year in jail.
Resolution recommending gun ownership legal, Shurtleff says
01/08/2013 6:50pmThe leadership of this remote town is within their legal powers to recommend that every household own and maintain a gun, according to Utah's former attorney general Mark Shurtleff.
Inversions could last for another month despite storms, meteorologists say
01/08/2013 7:05pmConditions are ripe for more inversions in Utah, and the snowfall the state already has is making the problem worse. Meteorologists say the conditions could mean these inversions will continue for potentially the next month.
Weber professors study concussions at Dew Tour
01/08/2013 7:51pmResearchers at Weber State University are taking a close look at concussions and how to minimize some of the long-term damage.
Number of LDS missionary applications doubles in 3 months
01/08/2013 8:39pmAn unprecedented number of LDS teenagers are signing up for missionary service since the lowering of age requirements. The number of missionary applications has doubled since then.
Utahn among those killed in Peru helicopter crash Monday
01/08/2013 9:59pmFriends and family of a Utah man killed in a helicopter crash in South America smiled through tears Tuesday night as they reminisced about an active and adventurous man whose primary concern was caring for his family.
Broken pipe floods Sandy business park
01/08/2013 10:09pmCleanup crews mopped up quite a mess at business mall in Sandy Tuesday evening, after a frozen pipe burst and flooded a vacant store.
How does Utah compare to the world's most polluted cities?
01/08/2013 10:23pmThey say a picture is worth a thousand words. A picture of the valley right now is worth at least a cough.
Jr. high coach dies following collapse at basketball game
01/08/2013 10:27pmStudents and teachers at Fairfield Junior High School are mourning the loss of a basketball coach who died after collapsing suddenly at a girls basketball game Monday.
'Honey Bun Bandits' suspected in another holdup
01/08/2013 10:48pmPolice say the two men dubbed the "Honey Bun Bandits" in a robbery and bomb scare at a Salt Lake City bank may also be connected to a holdup in West Valley City 10 days later.
Utah gas prices lowest in the nation
01/08/2013 11:59pmAAA Utah reported Tuesday that the current average price for a gallon of regular gasoline is $2.90 — dubbing the state's gas price the lowest in the nation.
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text:
Pinecrest hosts patriotic service
Pinecrest Presbyterian Church at 1790 Greenville Highway, Flat Rock, will hold its annual patriotic Independence Day worship service at 10:55 a.m.
The service will be led by Senior Pastor Rhett Carson and feature a sermon by Col. Doug Jones. The East Henderson High AFJROTC cadets will post the colors and conduct a flag-folding ceremony. Patriotic music will include the national anthem and "God Bless America," and the service will include the unfurling of the large "Vince Colan" American flag, closing with taps.
After the service, apple pie and ice cream will be served in Evans Hall. All veterans are encouraged to wear their uniforms. Call 828-697-9026 for more information.
Presbyterians to hold PC USA services
The continuing members of First Presbyterian Church who remain affiliated with the Presbyterian Church USA will hold weekly church services at 2 p.m. Sundays in Trinity Presbyterian Church's sanctuary.
Adult and children's Sunday school classes are offered at 1 p.m. at Trinity at 900 Blythe St.
The service is open to all. The Rev. Dr. Allen Smith will preach, and pianist Thommy Snead will provide music. A special message for children will be given.
First Presbyterian announced earlier this month that it is ending its affiliation with the Presbyterian Church USA and reaffiliating with the Evangelical Presbyterian Church. As part of the process, the church at 699 N. Grove St. will change its name in the future.
Email 1stPresHendo@ gmail.com for more information on the continuing First Presbyterian congregation.
St. James Episcopal to give guided tours
In celebration of its 150th anniversary, St.
James Episcopal Church at 766 N. Main St. will host special guided tours at 10 a.m. July 13, Aug.
10, 24, 31 and Sept. 7.
The tours will focus on the church's Gothic architecture, stained glass windows, and English-made pipe organ and tower bells. Visitors will observe the guild of change-ringers as they practice pulling ropes in precise sequence to swing heavy bells high overhead.
Rather than focusing on the bells, the special tour at 10 a.m. July 18 will showcase the Harrison & Harrison organ with 2,573 pipes. Organist Bradford Gee will explain how this powerful instrument complements the church's acoustic setting.
Each wall of the St. James nave and sanctuary offers large stained glass windows. The several dozen windows depict in realistic detail a history of Christianity, Anglicanism and the Episcopal Church.
The tour leader is parish archivist Charles Medd, known as a lively and wellinformed guide. No reservations are necessary, and tours begin at the cloister, the covered stone walkway near the entrance.
Call 828-693-7458, visit www.stjamesepiscopal. com or email info@ stjamesepiscopal.com for more information.
First Baptist to host community musical
First Baptist Church at 94 S. Gaston St. in Brevard will host a community musical at 7 p.m. Sunday.
The choirs of Little River Baptist Church, Enon Baptist Church, Grace Baptist Church, First Baptist Church and others will join to perform the patriotic musical "Stars and Stripes Forever" by Russell Mauldin.
The musical will be followed by a short keynote address by Brevard Mayor Jimmy Harris. During his address, he will emphasize the theme "In God We Trust."
Harris, a former member of the Air Force, will recognize veterans and active servicemen and -women of our armed forces.
There is no charge for the musical, and the public is welcome. Military veterans and active duty personnel are encouraged to dress in part or whole in their service uniforms.
Call 828-883-8251 for more information.
Grace Lutheran youth mission trip to Va.
Twenty high school youth and five adult guides from Grace Lutheran Church will travel to Onancock, Va., during the week of July 13-20 for a Youth-Works mission trip.
Onancock is on the Eastern Shore of Virginia on a narrow peninsula between the Atlantic Ocean on the east and the Chesapeake Bay on the west.
Nearly 2,000 participating churches will send more than 40,000 youth to 80 YouthWorks' mission sites this summer. Grace Lutheran youth will be joined by youth from congregations across the United States that have also selected Onancock as their destination.
YouthWork's core purpose is to provide lifechanging, Christ- centered mission trips.
During the week, the youth will lead Kids Club, which is a hands-on program offering high-energy games, crafts, skits, songs and interactive lessons all designed to help local children learn about Jesus.
They will also participate in work projects such as painting houses, performing minor home repair, cleaning up debris, volunteering in community gardens and other projects in the community.
The youth will be housed in a local church, and participants must provide their own sleeping bags and floor mats. Meals are prepared by the youth and adult teams on site during the week.
Previous summer faith service experiences have included places such as Philadelphia and New Orleans.
Call 828-693-4890 for more information.
Priest who advocates female ordination can't speak at local parish
Cardinal Sean O'Malley banned an Austrian priest from speaking at a parish because the priest advocates ordaining women and making celibacy for priests optional.
The Rev. Helmut Schuller was scheduled to speak at Saint Susanna Parish in Dedham on July 17 as part of 15-city U.S. tour. His talk has been moved to a nearby Unitarian Universalist church, The Boston Globe reported.
Terry Donilon, a spokesman for the archdiocese, said in a statement that the archdiocese's policy is "not to permit individuals to conduct speaking engagements in Catholic parishes or at church events when those individuals promote positions that are contrary to Catholic teachings."
Schuller is founder of the Austrian Priests' Initiative, which advocates allowing women and married people to become priests as a way to address a global priest shortage. The initiative organized a "Call to Disobedience," which was signed two years ago by several hundred priests who pledged, among other things, to begin serving communion to non-Catholics and promote women's ordination.
National Cathedral rings bells for gay marriage
The National Cathedral rang its church bells, along with some other Washington churches, to celebrate the Supreme Court's decisions on gay marriage.
Cathedral spokesman Richard Weinberg said the bells rang at noon Wednesday. Bells were also set to ring at other Episcopal, Methodist, Presbyterian, Unitarian and other Christian churches.
The cathedral scheduled a prayer service for gay, lesbian, bisexual and transgender families Wednesday evening to celebrate the ruling.
In a statement, the cathedral's dean, the Rev. Gary Hall, says the church is ringing its bells "to celebrate the extension of federal marriage equality to all the same-sex couples modeling God's love in lifelong covenants."
Hall says the ruling should serve as a call for Christians to embrace religious marriage equality.
From staff and wire reports
Religion Notes: June 29


text:
Perry, John › Page 30 - Fold3.com
You are here: Compiled Service Records of Soldiers Who Served in the American Army During the Revolutionary War › Virginia › Second Regiment › Individual › P › Perry, John › Page 30
Member Contributions for Perry, John › Page 30 - Fold3.com
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About this Publication TitleRevolutionary War Service Records
These are compiled service records for the regular soldiers of the Continental Army, and for the militia, volunteers, and others who served with them. The records are arranged under the designation "Continental Troops" or a state name, then by organization, and then alphabetically by a soldier's surname. Records consist of card abstracts of entries relating to each soldier from original records. Also included are regimental lists including muster rolls, pay lists, and caption cards.
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Anti-IL-5 Therapy in Bullous Pemphigoid (BP)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01705795
Recruitment Status : Completed
First Posted : October 12, 2012
Last Update Posted : February 28, 2017
|Tracking Information
|First Submitted Date ICMJE
|October 5, 2012
|First Posted Date ICMJE
|October 12, 2012
|Last Update Posted Date
|February 28, 2017
|Actual Study Start Date ICMJE
|February 13, 2013
|Actual Primary Completion Date
|January 31, 2017 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Time period (in days) from start of therapy until relapse, mepolizumab vs placebo [ Time Frame: Before, at 3-9 months ]
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Complete list of historical versions of study NCT01705795 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Anti-IL-5 Therapy in Bullous Pemphigoid (BP)
|Official Title ICMJE
|Anti-IL-5 Therapy in Bullous Pemphigoid. Randomized, Placebo-controlled, Double-blind Study Evaluating the Effect of Anti-IL-5 Therapy in Patients With Bullous Pemphigoid.
|Brief Summary
|Randomized, placebo-controlled, double-blind study evaluating the effect of anti-IL-5-therapy in patients with bullous pemphigoid. The primary study objective is to determine the efficacy of an anti-IL-5 monoclonal antibody therapy, administered as 750mg mepolizumab, in patients with bullous pemphigoid.
|Detailed Description
Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease. It characteristically affects the elderly (>70 years) with an annual incidence of 5 to 35 per million. This is comparable with the incidence of eosinophilic esophagitis that we determined with approximately 14 per million. Eosinophilic esophagitis has been recognized as an emerging medical problem and, consequently, several studies with anti-IL-5-antibodies have been performed and are still ongoing. It should be noted, however, that, in contrast to eosinophilic esophagitis, the incidence of BP is dramatically increasing with an average of 17% per year. Moreover, with the increase of the proportion of the elderly in the industrialized world, the medical problems associated with BP will even be more visible in the near future. For instance, patients with BP have an increased mortality risk of 2.3. In the US, an increase in mortality of BP patients has been noticed from 1979 to 2002. Taken together, BP is a frequent disease that affects mostly the elderly.
BP often starts with extremely pruritic skin lesions resembling eczema or urticaria before vesicles and blisters arise. In 10-30% of patients, BP also involves the oral mucosa. Disease severity can be determined by means of the autoimmune bullous skin disorder intensity score (ABSIS) that evaluates the involved area as well as the disease activity. The disease is due to an autoimmune response to structural components of junctional adhesion complexes leading to the damage of the dermal-epidermal junction with subepidermal blister formation. Specifically, autoreactive B and T cell responses against the hemidesmosomal antigens BP180 and BP230 have been identified. Serum levels of autoantibodies to BP180 reflect the disease severity and activity. The T cells are memory CD4+ cells producing both Th1 and Th2 cytokines, mostly IL-4, IL-5 and IL-13. IL-5 as well as eotaxin are abundantly found in blister fluids. The production of IL-5 is indeed associated with blood eosinophilia and significant eosinophil infiltration in the skin of BP patients. Eosinophils are thought to be critically implicated in blister formation by releasing toxic granule proteins (ESP, MBP) and proteolytic enzymes.
Systemic corticosteroids have been widely used for the treatment of BP. Nevertheless, the use of steroids is limited by their side effects. in therapy-resistant cases, immunosuppressive drugs such as azathioprine, chlorambucil, cyclophosphamide, cyclosporine, methotrexate, mycophenolate mofetil are employed, but their corticosteroid-sparing effect and overall benefit in BP is highly disputed. 70% of the relapses are usually observed within three months, 85% within 6 months after stopping therapy.
Since eosinophils are characteristically found in the skin at early stages of the disease before blisters occur and contribute to tissue damage, targeting eosinophils by reducing their number and activation might thus be a promising alternative therapeutic approach. Anti-IL-5 antibody therapy has been shown to be effective in depleting eosinophils, e.g. in diseases such as eosinophilic esophagitis and hypereosinophilic syndrome.
To determine the safety and efficacy of mepolizumab in patients with bullous pemphigoid.
clinical trial with 750 mg mepolizumab over three months, evaluate time period from start of therapy until relapse, ABSIS-Score, Pruritus Score, Antibody levels, immuno pathological evaluation of skin biopsy.
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Condition ICMJE
|Pemphigoid, Bullous
|Intervention ICMJE
|Study Arms
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Actual Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Actual Study Completion Date
|January 31, 2017
|Actual Primary Completion Date
|January 31, 2017 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria
|18 Years and older (Adult, Older Adult)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|University Hospital Inselspital, Berne
|Study Sponsor ICMJE
|University Hospital Inselspital, Berne
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|University Hospital Inselspital, Berne
|Verification Date
|February 2017
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
A pretty afternoon outside in the garden Monday turned into a nightmare for a Hendersonville woman attacked by a rabid fox.
A pretty afternoon outside in the garden Monday turned into a nightmare for a Hendersonville woman attacked by a rabid fox.
Dee Ballenger was preparing her vegetable garden to plant this year's crops at about 3:45 p.m. outside of her otherwise peaceful home at 1 Penny Drive when she saw the fox.
"I saw something running up to me and I thought it was a cat," she said. "I realized it was a fox and I knew I was in for it."
The red-headed, gray fox — a wild animal that tends to shy away from people — made a beeline straight for Ballenger.
"I knew it was rabid the way it charged me," she said. "It wasn't wobbling; it was just very fast... It came at me fast and determined."
The fox bit her left hand, but she shook it off with the gardening glove she was wearing. Then the fox came at her again.
"It bit me about three times in my right leg," she said. "There wasn't much I could do. I had nothing to defend myself with."
Ballenger suspects the fox came to her yard from neighboring Bowman Road, where it had terrorized a lady and her daughter minutes earlier.
Animal Enforcement Sgt. Mike Marsteller of the Henderson County Sheriff's Office said they received a call Monday afternoon from a woman who was trapped in a car along with her daughter. A fox was circling their vehicle.
When officers arrived, the fox had moved on to its next target... Ballenger.
"It just attacked me," Ballenger said. "I knew I had to get help."
She ran back into the house, grabbed her purse and rushed to nearby Park Ridge Health. Ballenger received six injections during her two-and-a-half-hour stay at the hospital. She has three more shots to go.
"The worst ones were the ones they gave me yesterday," she said Wednesday. "It really did not hurt... I had a good nurse."
Gone are the days of painful rounds of stomach injections; shots are now given right in the wound. Injections post-exposure can cost thousands of dollars, and Ballenger said she is glad to have health insurance.
"They wouldn't let me leave the hospital without (the shots)," she said. "If I didn't get them, they said I'd probably die."
Marsteller said the fox bit another man off of Sweetwater Hills Drive later that night. The man knocked the fox in the head with a flashlight, killing it. The fox was sent to the North Carolina State Laboratory of Public Health for testing.
It tested positive for rabies.
Marsteller and about nine other officers were busy this week canvassing the area around Bowman Road and Penny Drive, off of North Rugby Road, to warn residents about the threat of rabies.
"The biggest job today is spreading the word and getting the message out," Marsteller said Wednesday.
Law enforcement officers were looking for stray animals and checking with residents to make sure pets are vaccinated. The affected area is spread over a radius of one square mile from Bowman Road.
A fox nuisance is typically a call for wildlife officers, Marsteller said, but this one turned into a threat to public health.
Health officials and animal enforcement officers are urging residents to ensure their pets' rabies vaccinations are current and to contact a veterinarian immediately if a pet seems injured from an unknown cause, displays unusual behaviors, or appears sick — even if the animal has a current rabies vaccination.
"Deductive reasoning says if it's attacking people, then it's logical to believe that it would have encountered animals while it was sick – domestic and wild," Marsteller said.
Residents who think their pet was exposed can call 828-697-4912.
Do not approach, handle or touch any stray animals, Marsteller warned.
"We cannot overemphasize the importance for people in this area and all across the county to have their animals vaccinated," said Health Director Tom Bridges. "Rabies is in our county, and vaccination is the law. It's there to protect not only our health, but pets as well."
The last confirmed case of rabies in Henderson County was found in a raccoon in Fletcher on Dec. 23, 2009, according to Henderson County's Animal Services online.
Rabies is a deadly viral disease affecting the central nervous system. Rabies can be prevented but not cured. A healthy animal or human can get rabies when bitten, licked or scratched by a sick animal.
For updates, call the Public Health Hotline at 828-694-4040 or visit www.hendersoncountync.org/health.
Reach Weaver at email@example.com or 828-694-7867.


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Nice Monday ahead, but this week's forecast calls for significant rain.
Conditions during the day today should be clear and relatively calm, with winds continuing to drop off throughout the morning– definitely a welcome break from the powerful gusts that buffeted the county yesterday!
By this evening, the clear skies should begin to give way to rain clouds.
Precipitation chances are expected to climb steadily through the night, and rain is then forecasted to stay with us through early Wednesday morning. Meteorologists are also calling for an increase in the winds again, beginning in the early morning hours on Tuesday. Sustained winds in the teens will be accompanied by gusts in the mid-to-upper 20's at times, and not dropping off again until mid-day on Wednesday.
Throughout all this activity, we could hear some occasional thunder, but no strong or severe storms are currently expected to develop.


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Kia Motors Corporation is a maker of quality vehicles for the young-at-heart. It was founded in 1944 and is Korea's oldest manufacturer of motor vehicles. As part of the Hyundai-Kia Automotive Group, Kia aims to become one of the world's premier automotive brands.
Kia Motors produce over 1.5 million vehicles a year in 13 manufacturing and assembly operations in eight countries which are then sold and serviced through a network of distributors and dealers covering 172 countries.Less...
Contact Information:
Al Attar Business Tower,
7th Floor,
Sheikh Zayed Road,
PO Box 31106
Dubai, United Arab Emirates


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The Smyrna High School JV boys basketball team improves to 11-1 on the season after last night's 49-40 win over Polytech.
The game had it's issues though as Coach Dontay Black said the fire alarm went off at Polytech towards the end of the first quarter, which forced everyone to leave the building and delayed the game for 20 to 30 minutes.
The Eagles were led by Greg Duggans, Latrelle Lee and Donte Ritchie with 10 points. Ritchie also had 9 rebounds in the game.
Next up for the 11-1 Eagles is a home game Friday against Dover. Smyrna suffered their lone loss of the season thus far against Dover earlier this season by a score of 74-66.
The game starts at 6 p.m.


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The Boys & Girls Club of Henderson County has applied to the Hendersonville Planning Board for a special-use permit to build a 9,600-square-foot, two-story building at 1304 Ashe St.
The building will be used for classrooms and be on the organization's property at the corner of Ashe Street and White Sparrow Drive.
The new facility "will provide the Boys & Girls Club with more space and opportunities to learn," according to a news release from the Tamara Peacock Company in Hendersonville, which will design the new addition and has donated the original design services.
"We are still in the exploratory phase at this time," said Kevin Lauritsen, executive director for the club. "We have that land. We are just seeing what we can do with it."
If the construction is approved, club officials will assess and identify their needs and start brainstorming strategies to raise funds, Lauritsen said. The building could be multipurpose for classrooms, large and small, for the clubs' 50 programs.
The Planning Board will consider the permit, accompanied by blueprints of the building, at its meeting July 8, and if approved, the project will be recommended to Hendersonville City Council for a vote at a later date.
The Tamara Peacock Company was previously Stuart Stepp, Architect. Stepp passed away last year. The company has worked on the new Fletcher Town Hall, Green River Fire Department, Mountain View Baptist Church, Gospel Warehouse, Henderson County Athletics & Activity Center, Stacey's House for SAFE and renovations at the YMCA.
Reach Schulman at 828-694-7890 or firstname.lastname@example.com.
Boys & Girls Club files plan for 10,000 square-foot facility
The Boys & Girls Club of Henderson County has applied to the Hendersonville Planning Board for a special-use permit to build a 9,600-square-foot, two-story building at 1304 Ashe St.


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Spares and Accessoires for Simson & MZ
Spares and Accessoires for Simson & MZ
Simson Spare Parts
Simson mopeds stand out owing to their extraordinary performance and are simply unbeatable as far as their reliability and ease of maintenance is concerned. To ensure that Simson enthusiasts enjoy their motorcycles for a long time, we offer a wide range of Simson spare parts from A to Z - high quality spares produced by well-known brand manufacturers or technically and qualitatively equivalent parts.
MZ Spare Parts
Until the fall of Communism in Eastern Europe, the MZ Motorrad- und Zweiradwerk GmbH was counted among the largest motorcycle manufacturers in the world. Due to their simple and clear design including easily replaceable components (suitable for several models), MZ motorcycles were really popular with people. Browse our online shop for plenty of motorcycle spare parts and appropriate accessories...
Vintage & Exotic Motorcylces
In the GDR (former East Germany), the motorcycle market was dominated by the later Simson and MZ models. Besides, IWL scooters, MZ RT, JAWA, EMW and even exotic Simson models roared through the streets (and some of them still do). Focusing on these motorcycle models, we offer a large number of spare parts and accessories in our vintage and classic motorcycle shop.
Clothing & Helmets
"The demands placed on motorcycle clothing are as diverse as bikers. We have just the right thing for you! Whether fashionable or retro, we offer a wide range of helmets, leather or textile clothing, Enduro or casual clothing, balaclavas, eyewear etc.
Care & Maintenance
Having a motorcycle not only includes riding but also maintainance and care - in order to prevent unnecessary repair costs and, what is more, for your own safety! Our wide range of products includes care essentials and everthing you need in case of a breakdown and/or to manage minor repairs.
Gifts & Merchandise
No matter whether they are football or motorsport fanatics - fans do have something in common, they simply show their enthusiasm! That is why you find plenty of gifts and merchandise in our product range. Simson & MZ merchandise or AKF gifts - a pleasure for someone who shares your passion!
The AKF online shop offers over 15,000 items, covering a wide range of spares and accessories for Simson & MZ, vintage and classic motorcyle parts, clothing and gifts. We provide a high quality and comprehensive service including purchase advisory service, manuals and video tutorials. Using our vehicle database and exploded views, you will certainly find the suitable spare for your motorcycle.
More about Bowden Cables & Speedometer Cables
Bowden cable set in black - for AWO Sport
Item No.: 10068768
Manufacturer: FEZ
incl. 19% VAT, excl. Delivery
Bowden cable nozzle black Ø3,0mm (5 meters) - for MZ, AWO, IWL, EMW, RT
Item No.: 10058147
Bowden cable nozzle gray Ø3,0mm (5 meters) - for MZ, AWO, IWL, EMW, RT
Item No.: 10067579
Bowden cable set in black (new type) - for AWO tours
Item No.: 10066856
Bowden cable set in black (old type) - for AWO tours
Item No.: 10066855
incl. 19% VAT, incl. Delivery
Bowden cable set in gray - for AWO Sport
Item No.: 10068769
Bowden cable set in gray (new type) - for AWO tours
Item No.: 10066854
Bowden cable set in gray (old type) - for AWO tours
Item No.: 10066852
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All prices include 19% German VAT exclusive of delivery. The crossed-out prices show the recommended retail or list prices quoted by the manufacturer.1Free delivery is available for orders above EUR 39.00 and only within Germany.2The delivery times given are valid for items that show as being "In stock" (Mo. to Fr., all payment methods except payment in advance by bank transfer, financing & collection). Dispatch within 2 days (within Germany), unless otherwise stated or specified (except express delivery).For delivery times for other countries, please refer to the shipping information.3The delivery times given are only valid for items which are in stock or can be ordered from a supplier, if immediately available (Monday to Friday, all payment methods except payment in advance by bank transfer, financing or collection).4Recommended Retail Price


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CNC machined Alloy 5mm headset spacer to suit A-Head steerer tube.
Buy Brand-X Components from Chain Reaction Cycles, the World's Largest Online Bike Store.
If you're not completely satisfied with an item you may return it within 12 months of purchase. We'll give you a full refund if the item hasn't been used or the component hasn't been fitted.More information on returns
Blue - Black


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Recently, I learned that inmates at the Butler County Prison sometimes consider the food there inedible. "Mystery" meat and gravies, and many times scarce portions of anything recognizable, are just a few complaints.
I contacted county health department officials. To my surprise, I was informed that the department does not oversee prison food; it is in fact the county Department of Corrections' responsibility.
I then contacted the state Office of County Inspection and Services director and was told federal guidelines under Title 37 require that "written local policy must specify that each inmate be provided a daily diet that is nutritionally adequate for the maintenance of good health."
Also, I learned how prison inspections are handled. The Butler County Prison is notified in advance as to the date and time an inspection will be conducted. If the prison passes that inspection, another inspection is not conducted the following year.
That means two years elapse between inspections.
The OCIS director's website says: "Corrective action, if any, is solely the decision of the warden and the county administrator/prison board of that facility."
While the OCIS has inspection oversight responsibility of county correctional facilities, the oversight is specific to Title 37 issues; the office does not have daily operational and investigative responsibilities. Any concern regarding a county facility should be directed to the warden of the facility.
I contacted prison officials and met with the warden and two deputy wardens. I was informed that the food served in our local prison is based on caloric count (3,000 per day), not nutritional value.
I was assured that the food served to inmates meets federal guidelines as outlined in Title 37, which states: "Regular and alternative menus shall be approved and signed by a registered dietician or licensed physician, or both, and the prison administrator on an as-needed basis, but no less than on an annual basis." I was told that the dietician who works at Sunnyview Nursing and Rehabilitation Center signs off on the prison food to deem it nutritionally adequate.
I called to verify this with the said dietician and was informed that the prison menus have not been reviewed for nutritional value for the last five years.
The current prison board members are Judge William Shaffer, District Attorney Richard Goldinger, Sheriff Mike Slupe and the three county commissioners. I would encourage all concerned family members of prisoners to attend the next prison board meeting at 8:45 a.m. March 26 to express their concerns.


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Parent Directory | Revision Log
|Links to HEAD:
|(view) (download) (annotate)
Avoid reserved names for functions and variables, bug 516092.
add amd64-fbsd keywords
add multiple inherit protection
No stable keywords for mips
let ebuilds set SRC_URI before inheriting the eclass
Default to svn, avoid breaking existing live ebuilds
Add git support for live packages using enlightenment.eclass
deploy E_ECONF as an array replacement of the MY_ECONF string
fix by Julian Ospald to use correct default working dir for enlightenment_src_prepare and EAPI=[01] #444344
Remove the minimum restriction from PYTHON_DEPEND; any version of python from the last several years will do the job.
Raise python dependency to at least 2.5, fixes the breakage caused by silently dropped support for python-2.4 in python eclass
Enable verbose output
naive bump of all EAPI-specific checks in eclasses to permit EAPI=5 where EAPI=4 was previously allowed
drop cvs support since anoncvs.enlightenment.org no longer exists
call epatch_user
Update copyright years in headers
see if the doc target exists before we try to build it #348626 by Thomas Kahle
Convert every instance of hasq to has.
simplify DEPEND setup with python vars
drop distutils support now that upstream too has dropped it
Add support for static-libs USE flag, including support for .la files removal and not yet committed support for svn revision checks in efl live builds
drop enlightenment_warning_msg now that things have stabilized quite a bit upstream
add support for python/cython by Michael Blumenkrantz et al, and start eclass documentation
Moving dev-util/cvs* to dev-vcs/cvs*
Add prefix keywords for enlightenment
Update enlightenment eclass as discussed on enlightenment alias
people rarely complain when a build works, so stop dumping warning messages during the normal build process
do dodoc only if file exists
After dicussion with vapier, updated e17 alias to firstname.lastname@example.com.
Updated mail for bug reports from email@example.com to email@example.com.
declare ESVN_SUB_PROJECT so the checkout in $DISTDIR matches upstream
snap state now tracks upstream snaps rather than gentoo snaps
pull in dev-util/cvs for live ebuilds as gettext (autopoint) needs it #245073 by Thomas Kuther
add support for svn #237852 by Thomas 'gimpel' Kuther and Night Nord
use `type -P`, not `which`
move EXPORT_FUNCTIONS to the end and use emake in src_install
x86-fbsd can use enlightenment
allow ebuilds to force autotool regen
allow people to override the WANT_AUTO{CONF,MAKE} settings as suggested by jakub
update autotool usage and punt old libtool hack code
add a notice when user overrides settings
add a workaround for crappy gstreamer
Force elibtoolize to be run before econf for Gentoo/FreeBSD sake.
update default anon cvs server
thinktux is broken
only spit out cvs info when emerging a cvs version
sh love
add info for e17 cvs mirror
allow people to use custom e17 cvs servers with $E17_ECVS_SERVER
*** empty log message ***
dont try to autogen if we dont need to
make the SRC_URI/KEYWORDS setting a bit more flexible to handle snapshots properly #103246
Fix imlib2 downloads and remove einfo in global scope
make sure we only glob numbers, not . #103246
fix typo pointed out by mr bones
fix snapshot detection
Remove ECLASS= and INHERITED= which haven't been necessary for a long time now
Remove ECLASS= and INHERITED= which haven't been necessary for a long time now
make sure we dont get a sandbox violation with symlinks
if gendoc exists, make sure it is +x #94110
dont need to hack autogen anymore
make the new snapshots unstable by default
allow ebuilds to set keyword state
new freedesktop SRC_URI
style updates
ppc64 support
remove C++ libtool checks #74488
fix syntax error (reported by Clemens Noss #73912)
add warning about live cvs ebuilds
update DEPEND
phear mips
inject arm
fix KEYWORDS
make sure we call the right unpack func when using cvs
releases should be stable KEYWORDS
default KEYWORDS based upon state
smarter autodetection of ECVS_MODULE and S
oops, forgot to also define ECVS_SERVER ... thanks to kernel_panic for pointing it out
oops, forgot to define ECVS_MODULE ... thanks to kernel_panic for pointing it out
use -9999 as version
make this sweet eclass even SWEETER YEAH
make live-cvs support simple
make live-cvs support simple
make sure we force a good version of automake
update the copyright info
add ia64 to the list
dont force autoconf 2.5 anymore
make warning messages even more pronounce
autoconf in DEPEND
mips and ia64 need deps first
arm isn't ready yet.
-fPIC should be all set now
change back DEPEND sytle
BSD license
better handling of EDOCS
wh0rd.de is no longer available ;(
proper DEPEND setting
add doc (gendoc) support
hppa needs pic
stupid weak autoconf
warning message
sexier eclass
eclass for dr17 pkgs
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The World's Most Powerful Art and Photography App - View Artwork On Your Walls!
The Pixels.com iPad app has revolutionized the way that artistic images are discovered, shared, visualized, and purchased. The app allows you to browse through millions of images from the world's greatest living artists and photographers and then interact with those images, artists, and photographers like never before. You have to see this to believe it. Watch the video, below...
Browse... Shop... Share... Follow... View Artwork On Your Wall... and More...
Do you like the artwork that's featured in this video? Most of the images belong to Jane Davies. Check out her portfolio. The images are spectacular.
Follow your favorite artists and photographers... post comments... reply to comments... upload images... receive notifications when artists you're following upload new images... manage your portfolio... visualize artwork on your walls using our virtual reality interface (yes, really!)... purchase artwork from within the app... and much more...
Browse through millions of images from the world's greatest living artists and photographers!
Artists and photographers... show off your portfolio to your family, friends, and prospective buyers.
Show them what your images will look like hanging on their walls using the iPad's built-in camera - yes, really! Preview your images as framed prints, canvas prints, acrylic prints, and more!
Just imagine - all of the images on FAA... including your entire portfolio... in the palm of your hand.
Browse through millions of images from the world's greatest living artists and photographers.
Follow your favorite artists and photographers, and discover which of your existing Facebook and Twitter friends already use the app!
Receive notifications whenever someone comments on one of your images... or whenever someone you're following uploads a new image.
Print out our wall target using your home printer. It will print out on a standard 8.5" x 11" piece of paper.
Tape the target somewhere on your wall where you want the artwork to appear (e.g. over your fireplace). Don't worry about being perfect with the positioning.


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** Breaking ** BlackBerry Storm owners click here >>
Though we have known for a while now that Slacker would be coming to BlackBerry smartphones, it was only earlier last month at CES 2009 when the official launch was made (read Press Release). Speaking of CES, while down on location in Vegas we we also recorded an awesome video overview of Slacker Mobile Application for BlackBerry smartphones by the company's Director of Marketing Communications (video after the jump).
Slacker Radio Plus: While Slacker Personal Radio on its own is awesome and free, upgrading to the Radio Plus Service provides a few big benefits, including unlimited skips, unlimited song requests and no audio or banner ads. The cost to upgrade is $3.99 per month (billed annually at $47.88).
Contest Time: Sweet! Slacker is offering us up 25 1-month subscriptions to Radio Plus to members of CrackBerry.com, so you can really take Radio Plus for an extended test drive. For your chance to win, you only need to do two things:
- have a valid email address tied to an account setup at Slacker (ie. try the service!)
- login to CrackBerry.com and make a comment to this blog post!
Contest entry closes Thursday night at midnight EST. The bad news is that Slacker is only in the USA, so that limits the the contest a bit (sorry readers from Canada and around the world!). Good luck to those who enter! Be sure to visit Slacker.com for more info and to register your account if you haven't done so already.
Video: Slacker Mobile App for BlackBerry Smartphones


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One-Of-A-Kind Embroidered Leaf-Motif Organza With Satin Overlays
Decorate the table cloths with these beautiful overlays. Designed using delicate see-thru organza, combined with the standout nature of satin to create an exquisitely tasteful winding Leaf-Motif embroidery specifically made to give you this lovely fabric in its many forms and uses. Definitely nothing else in the market carries such an avant-garde design.
If you like the center stage, then this fabric is the perfect way to break the ice and create discussions with friends. Whered you get that?, Ive never seen this before., You have a great eye for new things. are the likely feedback you will get from your audience.
Also can be used to make huge bows or large area decoration. Available in 23 colors.
How to Care: Hand wash only. Hang dry, don't use dryer. Material: Organza with Satin Leaf Embroidery & Approx 3.5" Satin Borders Approximate Measurements: 60" x 60" Edges are Serged.
Click the "view more images" link above to review our color chart for this one-of-a-kind overlays.
We are confirming your subscription now...


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South Africa online marketing companies list offer full innovative services, integrated digital strategic marketing b2b ad campaigns. Assisting organisations, corporate or business of all sizes on all [tags].
Our services are offered with one of the best ad agency. Our technique permits us to create distinct campaigns that stumble upon the board. We do not outsource a single aspect of our work. Every project is produced, handled and implemented in-house. A strong project needs a strong marketing technique. What works best for them will not work best for you. That's why we strategise. Our proficiency extends beyond simple marketing. From social media, print, outside and web, we produce whatever had to build extraordinary results. Having actually handled some of the biggest brand names in the South Africa and established projects throughout the country, we know what works best for you. Everything we do is customised for your business. Constantly. You get the best outcomes for your needs, and it's constantly built for you.
The world of marketing is moving more to digital. From advertising to inbound marketing, digital is a cost-effective and adaptable medium to market your business in.
Are you struggling to accomplish your marketing goals? Call our consultants in to have a look over your approach and advise on more effective ways to market your service. We supply hourly consulting services to examine your advertising, branding and marketing approaches.
No marketing works without a comprehensive technique. Our professionals are experienced at developing methods and prepare for a broad series of markets, focusing on the very best marketing components and messages that achieve the business's brief and long term goals.
Brands love us because we are a special tactical marketing company. We integrate the method and imaginative branding talents of a conventional ad agency with the production abilities of the world's top-ranked event marketing agency. All our customer relationships are strategically handled – we've established our procedures and tools to unite technique and innovative so that even the tiniest information is critical.
Full-service advertising and marketing firm. We work with a wide variety of customers, from regional entrepreneurs to large global brand names, to create everything from simple printed pamphlets to incorporated projects that cover digital and social networks, video and television, outside and print.
B2B Advertisng and Digital Marketing Firms
Marketing basically means putting the right product or service at the right price, in the right place, at the right time. However, no matter how simple the marketing definition is, it takes a lot of work, the creation and implementation of a sound marketing strategy plan before you can see the fruits of your labor. First of all, you need to find out what your target market wants and identify their shopping habits. You also need to evaluate how you will be able to create a product or service at a price that will represent value and quality for them. This is where the marketing-mix comes in.
A marketing mix helps you get through your marketing strategy plans for any product or service you are thinking of and in the process, helps you stay away from common mistakes that may affect your business. However, although the 4 Ps of marketing and the marketing mix are often used interchangeably, these are two different terms. The marketing mix is a common phrase that is used to refer to the choices an organization has to make within key factors in the mix when introducing a particular service or product to market. The 4 Ps on the other hand relates to the key factors, which define the marketing mix.
What Are The 4 Ps?
- Product/Service
The first P is refers to the Product (or service) your customers want. When you define a product, it must have something that will satisfy the needs or demand of your target market. Among the factors you need to take into consideration is the How? When? and Where? Your target customers will likely use it. Branding is also important. Just like with any marketing strategy plan, your brand will represent your company and this must not just be treated as a simple name you want to call your product or service. Your brand will be the differentiating factor against your competitors.
- Place
The second P refers to the place where your customers will buy your product or service. Is it online or via a brochure or catalogue? Will you expand your distribution to include a big retail supermarket or only through a specialized boutique?
- Price
The third P is the price of the product or service you offer which is also its basic value to the buyer. Establishing a standardized price point might help but you also have to make sure that this will be suitable to the financial capacity of your target market.
- Promotion
The fourth P refers to Promotion. This is how you will promote or market your products or services which often reflect your marketing strategy plan. A good promotion and marketing campaign will be a significant factor in establishing your brand in the market.
When integrating the 4 Ps into your mix marketing model, you have to make sure these four factors interact with each other seamlessly. With just one element wrong, it may have a negative impact on your entire marketing strategy plan.
How work with: JHB online marketing companies list
For many years, we've had the privilege to develop and reposition brands throughout various industries, including packaged goods, production, professional services and retail. Our event team has managed gatherings for groups as small as 20 and as large as 2,000. They are some of finest event coordinators in the business. Vela's public relations personnel has provided proactive and reactive PR efforts and media relations support for a great deal of extremely various business and companies in our area, and we have actually been the owning force behind numerous local political campaigns.
Vela's specific niche in advertising and marketing is not a market– it's an approach. We work carefully with our customers, put in the time needed to understand their goals, and offer the creative technique necessary to accomplish them. Then we commenced to get it done, through the relentless pursuit of perfect execution.
We're proud to be recognized for our acclaimed imaginative efforts, but what matters most is the success it has brought our clients. Since at the end of the day, it's not about us. It has to do with you.
B2B marketing is highly specialised and in some cases downright difficult. Leveraging the power of digital marketing and B2B avenues can lead to high ROI. Establishing a strong brand name & strategy is the primary step, while utilizing approaches such as digital marketing and content marketing constructs know-how awareness and long-lasting organisation development.
Taking a business into the future needs an efficient digital marketing technique. From social networks to marketing and advancement, online technique is crucial.
There is constantly a location for the more conventional advertising and marketing techniques. Outside, indoor, radio and print projects are necessary to reaching a big audience.
Working with SME marketing has actually constantly been very important to us. From branding to marketing and digital marketing, we work hand in hand with SMEs to grow.
Website Marketing Strategy and Full Creative Services
Material marketing is all the rage now. It's a broad term for social media, email marketing, blogging, SEO and more about marketing business, Johannesburg South Africa Branding & Design
With our graphic style department we offer extraordinary brand management and security. We create for start-ups and corporates alike, making sure brand name consistency and efficient execution of printed or made collateral.
With our advertising group, we developed imaginative projects throughout digital and standard media. Our series of know-how includes media planning and purchasing, imaginative and execution.
With our variety of services and expertise, we evaluate exactly what your objectives are and develop a marketing method to attain them. With years of experience throughout industries, we produce a solution unique to you.
Digital advertising is one of the most reliable marketing tools offered. Part of our digital department, our website development services are 2nd to none.
THe Difference Between Digital Marketing and Social Media Marketing
Join JHB online marketing companies list and you'll spend approximately 3 months working in our offices finding out the ins and outs of how we operate. We'll work with you to become an amazing online marketer, company owner, and DFM agent.
We conceptualised the Coz Fresh is Our Thing project, building a cross-media campaign that showcases the brand freshness and item offering to the South African market … marketing business, marketing company in South Africa.
View Job developed in a brand-new branding principle. It concentrated on reproducing the unique feel of the lodge together with the environments in Tanzania … marketing business, marketing company in south Africa.
All our project managers are trained marketing professionals with experience in the market. All of our design and advancement work is checked by the head of the department and the imaginative director before sending out to the client. This indicates that the quality of our work is extremely high, constantly.
Consulting Digital Marketing - B2b advertising for Small Businesses
Individuals that operate at Inflex Marketing are an interesting lot, who are all enthusiastic about what we do. That enthusiasm is transformed into your brand – every customer, no matter how big or little gets the exact same fantastic treatment.
Throughout the years we've developed a method to obtaining jobs done, and how we charge, that is unique and offers extraordinary worth to our customers. Our charges are standardised across the board – so you always know exactly what you're getting.
Absolutely nothing we create or establish is based on a template. You always get something special, developed and built totally for you. We've constructed a variety of online platforms that permit us to provide you the value that you are worthy of.
Providing a series of services that are incorporated into a complete approach for you, delivering the best outcomes. From sites to graphic design, advertising, and activations, we're experienced in all spheres of marketing. The high quality of work we provide, and our in-house production lead to remarkably high value for our clients. No cheapie graphic design or templates to make our lives simpler – we do it effectively.
Building Terrific Websites that Influence Individuals. Every day we see thousands of sites that are developed exactly the same way. With the same design, and the same old approach. That's since a substantial amount of the websites out there today are made with WordPress.
Social media marketing is among newest, and at the same time, least understood approaches out there. It's the top marketing avenue that small businesses point out as the one that they require assist with, as well as the one that tops the list of "crucial marketing techniques".
There's a lot of articles composed, conversations had and infographics made about the powerful impact of colour in defining a brand name. Does it really matter?
Integrated Marketing Services
Exactly what makes an excellent logo? Well, to start with it doesn't cost R100. That's for sure. If you think that somebody can produce a brand for with that type of financial investment, you're seriously ignoring the significance of a great brand name, and underestimating your business.
Welcome to sms Digital, a digital marketing agency based in Johannesburg Gauteng South Africa, Pretoria, Sandton, and Cape town. Our honest and transparent digital marketing work speaks for itself. We deliver a personal, enthusiastic & customized service to each and every one of our clients, huge or little. We highly think that there's no benefit in a 'one-size-fits-all' method to SEO or SEM. Our digital marketing methods are ingenious and constantly prepare for the intent of your consumers and search engines.
If you desire clear, honest and tangible results online with the chance to discover how they're accomplished then contact us now to see how we can assist.
'Staying up to date with the Queen' is a single-page website developed to commemorate the Queen's 90th birthday and a showcase of the possibilities of tactical material marketing. The site has been extremely effective in terms of uptake in mainstream media and social reach.
Our network of thoroughly chosen, highly gifted, independently ran marketing & advertising agencies with digital. Digital Company Network serves fresh news, innovative work and helpful guides from and for popular digital agencies of the world, every day.
Integrated Marketing Company
Blend Media is a results-driven, digital marketing agency specializing in website design, mobile app development, and internet marketing. They grow brand names online.
Aysh is home to respected digital experts who deliver Search, Social, Paid Media and Material Marketing. They blend innovation and talent to attain magnificent results.
S&S is a digital innovative and marketing company in Vancouver and Toronto. They develop sites, iOS apps, content marketing, social networks & marketing campaigns.
Kook includes a group of award winning designers and developers helping brands tell stories, develop audiences, and provide content through the web, mobile and social networks.
Working with their talented designers, developers, videographers and strategists Battalion produces ingenious work for a series of tech, way of life & music market clients.
Developed in 2011, Clitag Interactive is a complete digital firm that delivers brand name experiences utilizing a combination of style, technology and media.
Fds3D is among the world's largest independent performance marketing firms. They run Pay Per Click, Show, SEO, Content and Social methods, backed by a leading team.
Hex is a full-service digital engagement firm. They combine an enthusiasm for imagination with a deep understanding of data and the digital landscape to deliver meaningful, totally responsible digital experiences.
Croorm's objective is to assist forward thinking customers develop, work and believe with a digital-first method. They think that effective work online is driven by good ideas and a design-led strategy. They produce work that pushes your company forward.
Hugat is a digital company which blends method, creativity and technology to build measurable client engagement throughout web, mobile and social. As a growing group of specialized experts, they deliver impactful work that has the power to change brands. 760i, an award-winning digital marketing firm, is run by a team of digital marketing leaders with a history of building ingenious and game-changing business.
80 days is a creative & digital marketing company, specialising in the high-end travel sector. They work thoroughly with distinct luxury hotels & international hotel collections. A complete, branding, digital and design company based in Glasgow and London. 2 offices. One aim: to create effective, inspirational design and interactions.
Ablute is a digital firm in Nottingham, England, specialising in website style, development and Magento e-commerce. Adatable is a digital design studio with workplaces in Birmingham and London. They integrate digital workmanship with innovative thinking.
Through technique, design and technology, Adido crafts digital experiences that make brands stick out and get the attention they should have.
Some firms specialise in digital marketing; some focus their efforts entirely on experiential marketing; and others not do anything however direct marketing. Integrated marketing firms, however, are a completely different another tune.
Integrated marketing firms are a little bit like Toys R United States. Ok, they're not "wonderful locations" with "toys in their millions all under one roof." Nevertheless, if you replace the word "toys" with "marketing services", you have actually basically strike the nail on the head.
Basically, integrated marketing firms are business that can please all of their customers' marketing requires under one roof.
Integrated marketing firms have the capability, resources and know-how to carry out a series of various marketing techniques in one cohesive effort. These business boast large groups of experts with various areas of proficiency throughout a vast array of marketing and interactions disciplines.
These various groups then work together to make sure their customers' projects are as efficient, meaningful, constant, harmonious and, therefore, as effective as possible.
What Is Digital Marketing? The Terrible Misunderstanding
In the world of business development and branding, going digital is all the buzz. So just what is digital marketing and how can we use it to grow our businesses?
Digital Marketing Defined
Digital marketing is the advertising and promotion of businesses and their brands through digital media channels. Digital media, at the moment, includes websites, social media, radio, television, mobile and even forms of traditionally non-digital media such as billboards and transit signs. Essentially any marketing media that is delivered electronically is considered digital marketing.
This leaves only various forms of person-to-person (P2P) marketing, print advertising and direct marketing outside of the digital marketing umbrella. Even then, print ads, direct mail, print directories, billboards and posters are all starting to connect to their digital counterparts. With items like URL landing pages, QR codes, web banner advertising, online directories and text codes, traditional marketing and advertising almost always has a digital marketing connection.
Why the Focus on Digital Media?
The shift to digital media is being driven by marketing agencies, business owners and consumers alike. The ever-increasing demand to show quantifiable results makes going digital a dream for the digital marketing agency. Most digital media, including websites, social media and mobile advertising is much easier to track than traditional marketing media such as print advertising.
For business owners, many forms of digital advertising are very low cost. Having a web presence, engaging customers in conversations through social media and e-mail marketing are low cost alternatives to print advertising and direct mail. These digital channels are available to businesses of any size, and help to even the playing field for start-ups, small businesses and independent consultants seeking new business.
For consumers, the fast pace of life makes digital advertising a must. When consumers are in need of goods and services, gone are the days of thumbing through a phonebook to find them. Now, we whip out our mobile devices or head to our computers for answers - and we find them fast.
Using Digital Media to Build Your Business and Brand
No matter what size your business is - large or small to medium sized business / enterprise (SMB or SME) - you can effectively market your business through low-cost digital channels. The foundation of your marketing efforts will be your website. Invest wisely in your website, and be sure that it does the following:
- Adequately represents your business and brand (look and feel, messaging)
- Adequately speaks to your target audience
- Can be found by searchers on top search engines
- Is up-to-date and easily navigable
- Provides multiple channels for customer communication
- Connects to other marketing efforts
It is recommended that you work with a professional web design firm that is skilled in web development and search engine optimization. Because your website is the foundation to and from which all other digital channels will lead, it should be considered one of your top business investments.
Once you have your website complete, the next steps would be to launch regular monthly or bi-monthly e-mail campaigns, and connect with customers via social media. If you are truly on a shoestring budget, these are efforts that can be done in-house (by someone with the proper knowledge) or for a low cost by an outside digital marketing agency. Be sure that all of your efforts lead customers back to your website where they can fully engage with your business, products and services, and choose the channels through which they contact you.
If you're interested in getting aggressive with search marketing, you can set aside some digital marketing dollars for search engine optimization and pay-per-click advertising. Many businesses today rely heavily on being found online to gain new customers. A common misconception among business owners is that simply having a website means that customers will find it. Not so. Your site must be built with specific key words and phrases, meta data, page content and linking strategies that will help it reach top search rankings.
Because many key words and phrases have stiff competition for top search rankings, you will need to supplement your organic search engine optimization efforts with pay-per-click advertising. Getting established with pay-per-click advertising campaigns can be a little daunting, but with a little time, effort and instruction, that too can be accomplished in-house, or for a reasonable cost through an outside digital marketing agency.
Beyond e-mail, social media marketing and search engine marketing, you can venture into a host of other digital marketing efforts. Mobile advertising, radio, television, electronic billboards and much more are available as marketing outlets. Whatever digital efforts you choose, they should all connect and tie into your foundation - your company website.
If you have the means, a wise investment would be to engage the services of a digital marketing agency to assist in your marketing efforts. Today, many digital agencies offer multiple levels of service to accommodate businesses large and small.
The majority of incorporated online marketing companies list use a mix of all, or a few of, the following services: digital marketing, direct marketing, experiential marketing, PR, advertising, guerilla marketing, social media, sales promotion, B2B communications, mobile marketing, buyer marketing, sponsorship, CRM, graphic style, copywriting and brand name strategy.


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Posted on February 9, 2012
We've just received word that FamilySearch is increasing the prices of film loans in the U.S. and Canada on February 15, 2012. The organization says it is due to higher costs of raw microfilm stock and higher costs of shipping.
The new prices will be:
- Short-term film loan $7.50 (formerly $5.50)
- Short-term film loan extension $7.50 (formerly $5.50)
- Extended film loan $18.75 (formerly $13.75)
The price of a microfiche loan remains the same: $4.75. If you are thinking about putting films on extended (permanent) loan, now is the time to do so and save $5 per reel.
As a reminder, films are no longer ordered through the Newberry. Films should be ordered via your individual account at: https://www.familysearch.org/films/. For more information about the online ordering process, see: http://www.newberry.org/online-lds-film-ordering-begins-newberry
We apologize for the late notice. Please do not hesitate to contact us at 312-255-3512 or at email@example.com with any questions.


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Every week this session seems to feature a new high-profile and volatile issue to be debated. Last week, it was the start of the school finance bill. Colorado's approach to funding our schools has been incredibly complex and difficult to understand. There's a formula that takes into account many factors which then determines how much funding each school district will receive from the state.
Getting to fair and balanced funding of schools hasn't been achieved and is evident in my Senate district. I was hopeful that those working most closely on the new formula would be able to arrive at something that would transcend the rural versus urban disparities.
The bill sponsors hope to arrive at a new formula that would be sufficiently popular to help pass a billion dollar tax increase to be proposed this fall for a statewide vote. It's an ambitious goal and one that will require buy-in from across the state to succeed.
I've been very fortunate to have a number of fully engaged school district superintendents and school board members who are not only monitoring the situation from afar, but traveled to the Capitol to testify in the Senate education committee about how the new proposed formula fell short of an equitable approach for some of the rural areas of the state.
Amendments were made to address at least some of the problems, but it was done in a rush. The dust hasn't yet settled on what was done and it remains to be seen whether those amendments will survive through the debates in the Senate and over in the House.
While all of this was happening, I was in other committees, getting three of my bills passed out of committee. Two of those bills address improving Medicaid fraud detection and recovery of misspent funds. There's still a lot to do to reduce Medicaid fraud, and a recent study by the Pew Center estimates that between 7 and 9 percent of the Medicaid funds are paid to fraudulent claims.
Medicaid expenditures at the state level are on a trajectory to overtake the only other area of the state budget that's larger - K-12 school funding - so, addressing Medicaid fraud has been a high priority for me. I've carried a number of bills addressing this topic and am pleased that the advocates for Medicaid beneficiaries in the disability community have been strong supporters of my bills.
I also had two bills signed by the governor this week. One was the bill allowing electronic participation in meetings by school board members and the other was making some changes in the Colorado Commission on Indian Affairs, which was also sponsored by the two state representatives in my Senate district, Representatives McLachlan and Coram.
Sadly, the events of the past week were overshadowed by the ruthless murder of Colorado's Department of Corrections Director Tom Clements. Details of the killing are still unfolding, but there will be no adequate explanation of why this thoughtful and kind public servant was shot at the door of his home. I knew Director Clements from working with him on the criminal justice commission. His tragic death is a great loss for Colorado and my thoughts and prayers are with his family and coworkers, including the governor.
Ellen Roberts represents Senate District 6 in Colorado's General Assembly. The district encompasses Montezuma, Dolores, La Plata, Archuleta, Montrose, San Miguel, San Juan and Ouray counties. Contact Sen. Roberts by phone at (303) 866-4884, or email firstname.lastname@example.com.


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Candidates Dean Brookie, Christina Rinderle and Keith Brant were the big winners in Tuesday's Durango City Council election.
Brookie, an architect, got the most votes at 2,564.
Rinderle, the only incumbent, was the second with 2,392 votes, and Keith Brant, owner of Durango Premier Vacation Rentals, was third with 1,593 votes.
Brookie will be the mayor in three years based on being the top vote-getter and the council's tradition for rotating the gavel.
"I had no clue (about getting the most votes)," Brookie said. "You just never know. I have never run for anything. It's a new experience for me, and a wild and crazy adventure."
Rinderle said her re-election was a validation of her first term.
"It feels good to know with all the controversy around accessory dwellings ... that I'm moving in the right direction to represent the public," she said.
Brant, who emphasized his financial expertise during the race, said he thought "my message resonated. 'Spend the money wisely.' It wasn't that complex."
Failing to earn City Council seats were Floyd Patterson, 1,140 votes; Kristen Smith, 704; and Jordan Golson, 625.
The election, which saw six candidates vying for three open seats, had 3,442 votes, or about 37 percent of eligible voters, cast.
The three top vote-getters will be sworn-in April 16, joining incumbents Dick White and Sweetie Marbury.
A few voters on Tuesday explained their choices.
"I voted for Rinderle and Brookie, not because I agree with them on every issue, but because they were the only candidates who were informed and thoughtful about issues facing Durango," said Dan Money on Tuesday.
Josh Martin said he voted for Golson because of his emphasis on technology and for architect Brookie because he liked his emphasis on historical preservation.
Another voter said he voted for Smith, a server at Ska Brewing Co., because "she works in the service industry" and for Patterson because "he wants to build a downtown parking garage."
The incumbency seemed both a blessing and a curse for Rinderle, with voters saying they voted for her or against her because of her record.
Voters also expressed some dissatisfaction with the quality of candidates.
"I watched the League of Women Voters' (candidates' forum) online. I spent a lot of time yelling at my computer," said the voter supporting Brookie and Rinderle.
"The other four candidates displayed an intense level of ignorance of city issues," he said.
Another voter said she found herself in the same predicament of indecision.
"I was looking for someone who was thoughtful, well-educated on the issues and shared some of my values, such as environmental sustainability. I had trouble finding three that I liked, and that's the truth," said the voter, who asked for anonymity. "It was tough. (My husband and I) ended up voting for two (candidates) whose positions were not necessarily aligned with our own."
"It's great when people show an interest in getting involved in their city, but you also want people who have a background knowledge to do this very important, serious job," she said. "Being a citizen is not a qualification for this job."
Herald Staff Writer Ann Butler contributed to this report.


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Le Mans Wedding Photographer
Le Mans Wedding Photography
As a pair of destination wedding photographers, we've long yearned to photograph a wedding in Le Mans and have not quite yet had the pleasure. Similarly, you're probably looking for a wedding photographer in Le Mans and have stumbled across us - we are so glad that you have!
We love meeting people from all over the world, and witnessing so many beautiful love stories and wedding traditions through our viewfinders. Both of us are passionate about telling stories with our cameras, and we hope our portfolio shows how much we treasure all the individuals, and places we have met in our global adventures. We truly cannot wait to see what kind of weddings, and people we will get to photograph next!
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Drop us a line! We would love to learn more about you, your story, and how we can work together!
Lisa and Fulya


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A fun and friendly kiosk for those who are looking for a quick bite, Nelson's offers delicious light meals such as chocolate-filled Belgian waffles, dorayaki as well as their signature Corn in a Cup. On top of that, Nelson's also serves delicious ice-blended beverages to help customers wash down their meals.
Opened in January 2007, Nelson's is the only franchise in Malaysia that offers these unique, sumptuous meals. The Nelson's kiosk at KLIA is one of a kind, appealing to all ages of travellers from all over. For more information, visit www.nelsons.com.my
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8 Ways to Protect Your Town's Water Supply
By Cris Carl, Hometalk
There are several towns in the U.S. that have a high standard of water quality, according to the Environmental Protection Agency. These towns include Aspen and Vail, Colorado; Georgetown, Texas; and Gatlinburg, Tennessee. These towns, by luck and by design, are well situated within healthy watersheds that have a low possibility of becoming polluted.
There are a number of important factors involved in the creation of clean, healthy drinking water. First of all, water supplies come from underground (aquifers), lakes, rivers, and sometimes desalinated sea water. Water is purified and disinfected with chlorine. Then the treated water flows either by pipes or gravity to reservoirs or water tanks. Once the water goes down the drain and into a sewer system, it is then treated and released back into a body of water or is used for agricultural or industrial purposes.
In order to have a reliable and continuous source of clean water, free of disease pathogens, municipalities need to have certain standards in place. As a consumer, it is also up to you to support efforts to protect your local water supply.
Here are 8 of the primary ways clean water supplies can be achieved:
1. Monitoring the water supply: Local environmental staff should be policing and inspecting watersheds on a regular basis. Environmental staff can include police, inspectors, laboratory technicians, lake crews, and foresters who work together to ensure the safety and quality of the ground water.
2. Your local land use commissioners, such as zoning and planning boards, should be carefully reviewing any applications that could affect water supplies: For example, while you may want to have a big box store built in your town, care must be taken to protect wetlands and aquifers. Large expanses of impermeable surfaces (parking lots) divert storm water in such a way as to potentially harm nearby water supplies. In addition, gasoline, oils, and other chemicals may also be washed into the water supply.
3. Stormwater treatment systems: Developers should always submit (to land commission boards) detailed storm water treatment systems to minimize any potential harm to water supplies.
4. The creation of man-made wetlands: It often helps to support water supplies when wetlands must be diverted or removed, but it is important to remember that man-made wetlands can rarely do the job of wetlands that naturally occur.
5. Buying and protecting watershed lands: The more protected land you have, the greater your town's ability to have a healthy water supply.
6. No dumping into storm drains. Material that enters storm drains ends up directly in the watershed.
7. Proper disposal of household hazardous waste and medications: While wastewater treatment plants continue to become more sophisticated, it is impossible at this time to filter out all chemicals and pharmaceuticals. Down the line, these chemicals and pharmaceuticals will end up to varying degrees in your drinking supply. Cities and towns that support proper disposal of chemicals and educational efforts for its residents usually will have a healthier water supply. Learn how to properly dispose of paint and medication.
8. Maintenance of native vegetation along-side streams and wetlands: The vegetation acts as a natural buffer, reducing pollutants and preventing erosion.
Keep in mind that you are a big part of whether your city or town has a clean and abundant water supply. Increased awareness, education, and participation in your local government are the keys.
Best & Worst US Cities for Water Quality
Top 4 Threats to Earth's Water
Getting Clear About Wastewater


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