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I love my smile, really it is but I love my teeth more than my smile. It is my teeth that make my smile super classing, I can sparkle, and I can laugh only because of my beautiful teeth. My smile makes me more beautiful and confident to see the world in a more realistic way. It's not what I say; it's the people who say like this .the smile is not the symbol of beauty, it's speaks of yourself so when you don't have a perfect smile. You really miss the most wonderful aspect of your personality.
How to get a beautiful smile
So wear the beautiful smile, if you have broken teeth then don't be afraid to consult with your cosmetic dentist and let them know what the real problem is. Your dentist can suggest you braces, or invisalign for the perfect teeth alignment. Yes, once your teeth get perfectly aligned then the other step is to remove discoloration if you have any. In case of stained tooth or yellow teeth, here are so many treatments.
Bleaching or tooth whitening treatment is used to remove the stain of the teeth. Simply you can get the whiter teeth than ever. Bleaching treatment may be done at the clinic of cosmetic dentists. Sometimes in case of minor discoloration dentist can suggest you to do such treatment at home. So this is very easy to get healthy white teeth and to have a beautiful smile. But this treatment is needed to be done after a fixed period. So you can get the beauty when you required it's no more in your dreams or added in wish list.
What are the ways?
Healthy white teeth are for all. What you need is to visit your dentist and consult with him. He will examine your teeth by taking X-rays and can recommend you some medication or some treatment. The most necessary thing is the teeth should be properly aligned. If there is cavity or broken teeth then to get a perfect smile become very difficult. If you have broken tooth then don't worry. Your Winnipeg cosmetic dentist can suggest you crown or caps for your teeth. In case of gap between the teeth, or in case of injury you lose your precious teeth, your dentist can recommend the bridge for your teeth. So tooth alignment not only can give you a perfect smile but it can change the shape of your mouth charismatically.
Can I have a perfect smile?
So come in shape and forget about your old look, this is how you can complete yourself. Once you got the perfect smile, you are ready to wrap the world onto your fingers. This is no more your fault, if it is by God, then he has certainly opens so many ways to regain your beauty. Don't feel hesitant if you have broken teeth, you can get perfect teeth. It does no more can harm your personality and you don't need to close your mouth publically. Show the world that you have the right to smile and you can smile more beautifully. You have every impression to attract the people. So it's your teeth and you know very well how to make you smile. So get ready to have a tempting smile.


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Ferrari SF 90 Stradale
Rent your New Ferrari SF90 Stradale
Ferrari F8 Tribute Spider
Rent your New Ferrari F8 Tribute Spider
Ferrari 458 Spider
Rent/Hire Ferrari 458 Spider. The car has been voted as "Sports Car of the Year"
Ferrari California Turbo
Rent/Hire Ferrari California Turbo. The car has been given a highly significant kick up the chuff courtesy
Ferrari California Portofino
Rent/Hire Ferrari California Portofino. We are talking of 600 Hp compared the California Turbo +40 Hp more
Lamborghini Aventador SVJ
Rent/Hire the New Aventador SVJ Roadster. The car is a completely open vehicle with sleek lines...
Lamborghini Aventador S LP 740R
Rent/Hire the new Aventador LP 740-4 S Roadster. The car is a completely open vehicle with sleek lines.
Lamborghini Huracan Performante
A design and an aerodynamics designed with passion by those who want to achieve very high goals.
Lamborghini Huracan Evo Spyder
The Huracán Evo Spyder was designed to take this thrill to the extreme.
Maserati Grancabrio
Rent/Hire the elegant convertible Maserati Grancabrio.The car has a 90 degree V8 of 4,691 cc,
Porsche 718S PDK - Spider
Rent/Hire Porsche has made big changes to the Boxster for 2017.
Porsche 911 Turbo Cabriolet
Rent, Hire Porsche 911 Turbo Cabriolet in Italy. It comes with a new line and 3.0 turbo engine.
Porsche 911 S Cabriolet
Rent, Hire Porsche 911 Turbo Cabriolet in Italy. It comes with a new line and 3.0 turbo engine.
Bentley Continental GT Cabrio
Rent/Hire The Bentley Continental GT Convertible offers a seductive combination of performance,...
Audi R8 Spyder
Rent/Hire the new Audi R8. Beautiful to behold, easy to live with, and simply marvelous to drive...
Alfa Romeo 4C Spider
Rent Alfa Romeo 4C Spider in Italy a sporty "tough", compact and lightweight weighing only 920 kg !
Mercedes C63 S AMG
Rent/Hire The 2017 Mercedes-AMG C63 S Coupe is a different car. Engine twin-turbo 4.0-litre V8.
Mini Cooper
Rent, Hire Mini Couper John Walker cabriolet. New design, new engine a great performance.

subset: commoncrawl


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"Jacob set up a pillar in the place where He talked with [God]." Ge 35:14 NKJV
When you recall God's faithfulness to you it causes hope to rise in your soul. It enables you to face the future with confidence and say, "He is the faithful God, keeping his covenant of love to a thousand generations of those who…keep his commands" (Dt 7:9 NIV). Looking back and remembering is a scriptural principle that works. "Jacob set up a pillar in the place where He talked with [God];" "Joshua set up twelve stones in the middle of the Jordan" (Jos 4:9 NAS); "Samuel took a stone…set it up…and called [it]…Ebenezer, saying, 'Thus far the Lord has helped us'" (1Sa 7:12 NKJV). The Bible says: "No test…that comes your way is beyond…what others have had to face. All you need to remember is that God…[will] always be there" (1Co 10:13 TM). Going back through Scripture and remembering the ups and downs of God's people and how He consistently came through for them, lends fresh perspective to your own situation and enables you to see a bigger picture. In Psalm 22 David starts out saying: "God…I call to you…but you do not answer" (v. 2 NCV). But as soon as he starts remembering God's faithfulness he does a 180-degree turnaround and says, "Our ancestors trusted you…and you saved them. They called to you for help and…were not disappointed" (vv. 4-5 NCV). When you're in a spiritual free fall, stop dwelling on yourself and your disappointment and begin to focus on God. "Not one word has failed of all the good promises he gave" (1Ki 8:56 NIV). He's still the same; He hasn't changed.
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Payday cash advance loans are often prolonged two weeks more frequently absolutely nothing, yet few increase your financial loans around Eighteen days and nights. If the fixed use of the time scale to be able to repay comes around and you also don't have the means to pay back the credit payable the financial payment and spin the payday loan up to the following pay. The actual period may become disparaging.
When the payday loan is approved, the loan companies will shipped the amount of money to your bank if you have direct saving capabilities. At that time the development mortgage loan is permitted you are going to go ahead and take transfer of instantaneously deposits in accordance with several payday lenders. Many financiers move the currency exchange into the checking account in 2 working days until you obtain financing in the territory base loan providers. The loan company who offer the payday advances tend to be rapidly and with all the mortgage approvals when the most payday loan firms will not likely look at the credit history. Many pay day web sites on the internet state their sites are discreet and risk-free. This is very important, as if their internet site is just not guaranteed and also specific, you're likely to be the subsequent sufferer regarding identity fraud.


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$63,540.88 gross recovery for stress-induced cardiomyopathy injury car accident in Dallas, TX. Outstanding settlement by attorney for client included all available injury claim policy limits.
Our client was traveling westbound on IH-20 in Dallas, Texas in the far left lane. An inattentive motorist changed lanes when it was unsafe to do so and struck a vehicle traveling in the left center lane before subsequently striking our client's automobile. Our client went to the emergency room following the collision.
Comments from Attorney Joseph Morrison: This was a very unique case. Our client sustained relatively minor neck and back injuries in the collision but her main complaint at the emergency room was chest pain. She was eventually diagnosed as having sustained a myocardial infarction secondary to Takotsubo cardiomyopathy. It is a temporary heart condition with symptoms that mirror those of a heart attack but it is not caused by any sort of cardiovascular disease.
Remember: Takotsubo cardiomyopathy is also referred to as stress-induced cardiomyopathy or broken heart syndrome.
We argued that the temporary weakening of the client's left ventricle, the main pumping chamber in the heart, was the result of the severe emotional and physical stress she experienced as a result of the car accident. We submitted settlement demands to the liability insurance carrier for the at-fault motorist and our client's underinsured motorist carrier. Medical research supporting our contention that motor vehicle wrecks can directly lead to Takotsubo cardiomyopathy was included with the respective demands. Both carriers eventually offered full policy limits even though the client's paid vs. incurred medical expenses were less than $10,000.
Adjusters almost always want to make cases about bills instead of about people. Even though this client's medical bills were relatively low, that did not change the fact that she undeniably experienced significant mental anguish as a direct result of the auto accident. Even though the physical symptoms were temporary, no doubt existed in my mind that both carriers should pay policy limits. I'm happy we were able to recover the available limits for her without having to file a lawsuit, which would have led to increased attorney fees and expenses.
The settlement for this claim involving a stress-induced cardiomyopathy injury as a result of a car accident in Dallas, TX was $63,540.88. Attorney fees were $20,000. Case expenses were $1,182.37. After paying medical providers, the client's net recovery was $32,500.97. This is a fantastic result at all available injury claim policy limits by our Dallas accident lawyer.


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Keychain - Sodalicious Gold Filled
Keychain - Soda-licious Glitter
Did someone say glitter?! Keep all your keys in order or make a backpack your own with this soda-licious keychain. A liquid and glitter-filled center makes it impossible to miss!
YOU BUY, YOOBI GIVES - For every Yoobi item you purchase, a Yoobi item will be donated to a child in need, right here in the U.S.
Product Details
- Dimensions: 0.2" x 1.38" x 3.15"
*WARNING - Choking hazard, small parts. Not for children under 3 yrs.
- Reviews


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Norway's least classiest band, TURBONEGRO, are now three albums strong since their much ballyhooed reunion in 2003. Their latest, Retox, certainly isn't a return to their filthy deathpunk past, but it's timeless much like their feel-good-but-feel-naughty rock 'n roll they've perfected of late. Having recently taken their raunchy rock 'n roll rollercoaster on the road, we pulled bassist, Happy Tom, aside for a quickie and a lightening round of questions to uncover the mystery of the German Shepherd, the homo shtick, and the magic of Retox.
Tag Archives: happy-tom
TURBONEGRO: Studio Update and New Website to Launch in December
TURBONEGRO bassist Happy Tom issued a very brief studio report via the Norwegian band's MySpace page:
"Fellas. FELLAS. Last day of bass guitar today, which means that the songs have more or less been STRUCTURALLY completed. New titles are kept secret until further notice, SORRY.
"We're STILL trying to get ahold of Nate Dogg for some backing vocals.
"Gotta go; the beer ain't gonna drink itself."
Meanwhile, it has been announced that a new and official TURBONEGRO website is under construction with a December launch date. The site will feature a complete historical biography, band diaries, tour dates, videos, an official merchandise store, and other exclusive stuff.


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Leica released M7 Titanium "50 Jahre M-System" single lens kit special limited edition of 500 limited sets and 3 lens kit of only 50 sets in 2004 to commemorate the 50th anniversary of Leica M system.
Decided to extend presence to areas outside Europe, Leica opened their first flagship store, the Leica Store Ginza, in Tokyo, Japan in 2006 to display full series of Leica products to Asian Market. Leica MP Titanium was introduced in April, 2007 to commemorate the first anniversary of the opening of Leica Store Ginza. It was sold only in Leica Store Ginza in Japan with 150 pieces of limited edition, without releasing to worldwide.
Leica, the origin of 135-format mechanical rangefinder cameras, has made a new legend to introduce Leica M Monochrom, the world's first digital black and white rangefinder camera, integrating traditional black and white with digital technology at May, 2012. Leica then continued to enhance black and white digital technology by introducing Leica M Monochrom (Typ 246) in 2015.
Summilux-M 35mm f/1.4 lenses are the best among 35mm lenses. 35mm wide-angle and f/1.4 large aperture create an excellent combination, which has captured lots of outstanding photos. The birth of Summilux-M 35mm f/1.4 ASPH (I) allows the image performance to reach a very high level, and Summilux-M 35mm f/1.4 ASPH (II) even consists of greatly enhanced optical design. It shows that Leica is able to go from a peak to an even higher peak.
This year is the 60th year of Leica M rangerfinder camera. In 1954, Leica released the first bayonet mount rangefinder, M3, which changed the history of screw mount rangefinder and opened a new brilliant page of M series. To commemorate the 60th anniversary of Leica M, Leica has recently released many new products at Photokina 2014.
Leica M5 received many criticisms on its camera appearance and size, leading to a large fall at Leica's selling performance. Leica made great efforts to examine the problem and launched M6 in 1984. M6's portable size and precise focus, together with its through-the-lens manual light metering, regained appreciation in photography industry. M6 even had a long production period of 20 years, making it the longest among Leica M series cameras.
Accumulating years of experience, Leica is able to keep enhancing the optical design of its lenses. After Leica stopped the production of Summicron-M 35mm f/2 IV 7-element in 1996, Leica introduced Summicron-M 35mm f/2 ASPH with optical design of 7 elements in 5 groups and an aspherical surface. The advantages of high image quality, fast and lightweight allow it to become the best Leica M 35mm f/2 lenses in the aspect of lens-making technique.
Leica, the creation king of 135 full-frame format mechanical rangefinder cameras, has walked through 100 years, produced lots of excellent cameras and lens, and given photographers artistic experiences they dream of. To commemorate the 100 years of glorious history, from the beginning to current, and from film photography to digital photography, Leica M Edition "Leica 100" with limited edition of 101 sets was released in 23rd May 2014.


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The 9000 Z001 landspeeder was a Ubrikkian model commonly used around the time of the Battle of Yavin. It was modified from the 9000 landspeeder, which had been aimed at Ugor customers but had flopped.[2]
Six-point-eight meters in diameter, it carried a single pilot, two passengers, and 50 kilograms of cargo. It could be modified to sit up to six humanoids.[3] The craft hovered up to three meters above the ground and its numerous viewports allowed its driver an excellent field of vision. While not the speediest of vehicles, able to achieve only 160 kilometers per hour, a ring of micro-thrusters around the hull granted exceptional maneuverability.
The 9000 Z001 was the predecessor of the 9000 Z004 model.
At some point before 27 BBY, Feena Ghel was selling one unit of this vehicle, customized for the local frozen conditions, in Elesa, capital city of Ando Prime.[3]
One of these vehicles was seen parked outside Chalmun's Cantina on Tatooine in 0 BBY.
The Mistryl Shadow Guard Karoly D'ulin used one of these vehicles to follow the pirate Zothip nearly two decades later.
Behind the scenes
This model appears to be a reference to Stanley Kubrick and his film 2001: A Space Odyssey, as noted by Pablo Hidalgo, whereas Ubrikkian was at one time spelled "Ubrickkian", and 9000 refers to HAL 9000.[4]
The July 4, 1982 Sunday Edition of the Star Wars comic strip's scrapbook section referred to the 9000 Z001 landspeeder as a "low life droid", even though it was actually a vehicle, not an actual droid.
- "Snow Job"—Star Wars Gamer 2
- A Hunter's Fate: Greedo's Tale webstrip
- Star Wars: Episode IV A New Hope (First appearance)
- Vision of the Future
- Star Wars: Yoda Stories
- Star Wars Sourcebook, Second Edition
- Star Wars Blueprints (as "Ubrickkian Landspeeder 9000 Z001")
- Artoo Detoo's Activity Book (as "robot")
- The Star Wars Sourcebook (as "9000 Z001")
- Galaxy Guide 7: Mos Eisley (as "9000 Z001")
- Star Wars Technical Journal of the Planet Tatooine (Picture only)
- Star Wars Sourcebook, Second Edition (as "9000 Z001")
- Star Wars Technical Journal (Picture only)
- Star Wars Customizable Card Game – Premiere Limited (Card: Ubrikkian 9000 Z001)
- "Arms & Equipment Guide Extras!" on Wizards.com (original article link, backup link)
- Inside the Worlds of Star Wars Trilogy
- Star Wars: Complete Locations


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Hey everyone. On Monday, Samuel went to see his pulmonologist, Dr. Newasker. She's the person who's be working with him on how to wean him off his oxygen. One of the critical factors in coming off oxygen completely has been to pass a sleep study, which took place about three weeks ago.
At any rate, Dr. N. spoke with Kristen about the results, and the bottom line is he needs to stay on oxygen at night for a bit longer. And by a bit longer, I mean until March, 2017. During the sleep study, he had a few results that were problematic, and it looks like he had some sleep apnea. So we'll continue to put him on oxygen at night and during longer car trips. He has no issues being off oxygen during the day or for short (less than 2 hours) car trips.
This is disappointing to me, but we'll do what's best for Sammy. I really love seeing him without his face stickers and oxygen tubing, and I know he likes getting this stuff off his face too.
He was supposed to have his swallow study again on Tuesday morning, but he's been under the weather – so has Jacob – and we delayed it. I think Kristen said it's now scheduled for sometime in late November. The swallow study will help tell how his vocal chords are working, and if he's able to start taking a bottle. Previously he was aspirating a tiny bit into his lungs, but a tiny bit is too much. He gets some Stage 2 food now and he seems to love it (most flavors anyway). He also handles it without any aspiration, so hopefully he'll be cleared to take on more. Feeding him through his G-Port is painful, as the area is often red and irritated. I really can't wait to get him off that feeding tube.
Sammy's also seeing his physical therapist weekly now, and Laurel is really impressed with his progress each week. He's working on tummy time and strengthening his upper body muscles, his core, etc. He's now able to bring his hands to his face, and if you put a toy in front of him, such as on a mobile, he'll reach out and touch it most of the time. He still has a long way to go before he'll sit up on his own, or even hold his head steady on his own. But the progress is definitely noticeable. We have to give credit to Stevie for this too. She's really been working with him each day and the progress shows.
Anyway, that's it for now.


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According to Lucy Siegle in the Observer today NUMBY is the new green word of the day:
A twist on the self-serving Not in My Back Yarders acronym laced with environmental responsibility. Not Under My Back Yarders oppose hydraulic fracturing, including shale gas exploration.
I guess we should not see NUMBY's as being as self-serving as their NIMBY cousin. Surely no one wants to live where there is the danger of a man-made earthquake? Surely everyone with an ounce of their sanity still intact is a NUMBY!
If you're not sure about why you should be against fracking check out these sites:
- No Fracking UK – A campaign that calls on the coalition government, the Welsh Assembly and the Scottish Parliament to impose a moratorium on shale gas, and on the related coal bed methane extraction industry, at least until the results of studies here, in other countries in Europe and in the US have been properly evaluated.
- RESIDENTS ACTION ON FYLDE FRACKING – A group of local residents who are calling for an immediate halt to gas extraction on the Fylde coast pending a thorough evaluation of the risks.
- Frack Off – Learn all about the tidal wave of increasingly destructive energy extraction processes threatening the British Isles.


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Best Shave – Tip Top Shaving Tips
By BB on site with Comments 0
Considering that shaving is the only facial beautification technique that most men ever use, let alone on a daily basis, means that we should define the best shave tips right? In fact, happily, shaving properly turns the act from a daily chore into a luxurious daily treat!
For the Butler Bureau the main points to consider when shaving are these….
- No chemicals, petroleum products or aerosols ( read your labels!)
- Get a Badger hair brush
- Ditch the electric shaver ( I hate them so much I ditched the company!)
- Turn a boring task into a pleasurable one
- Moisturize before and after
- Never splash anything on your face that's got alcohol in it!
If you shower or bathe every morning ( advisable :-) leave the shaving until last. That way your skin is nicely warmed up and clean ( wash your face with your nice mild, chemical free shampoo to get it ready for the blade).
QUICK TIP: Don't add moisturiser prior to shaving until you've closed your pores with cold water. Otherwise you will simply be clogging up those warmed open pores with the moisturiser.
I think my only concern here in this is the shaving against the grain ( or direction of hair growth) that's never worked well for me – but maybe I'm being overly sensitive! I guess if your skin is superbly moisturised it shouldn't matter.
This post was going to originally be a series guidelines for men shaving themselves. But for Butler/Valets who shave their employer on occasion here's a video from a professional barber ( once again my only problem is the shaving against the grain or direction of hair growth as that's where skin irritations, and ingrowing hair problems, stem from – if your blade is sharp enough it shouldn't be necessary surely).
I suppose what I'm saying here, in general, is that a shave is, or should be, regarded as a daily pleasure rather than a chore. Apart from the fact that your skin tone will show that you know how to shave sensibly it's just another aspect in the 'Butler Way' of doing things properly! It also helps if you have the right equipment. A Bic disposable and an old bar of bath soap just doesn't cut it – literally!
Related posts:
Filed Under: Butler Secrets • Multimedia • On The Job • Training Issues • Valet School • Videos
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Angie's List Answers is the trusted spot to ask home improvement and health questions and get answers from service companies, health providers and consumers. For ratings and reviews on companies in your area, search Angie's List.
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text: According to Collider Disney is working on a live-action prequel to its 1992 animated classic, and one of my personal favorite Disney movies, Aladdin. The project will be titled Genie and will obviously center on the story of Genie prior to the events of Aladdin. With the box office success of previous live-action adaptations of the stories that Disney had previously comprised their animated classics. The studio has put a ton of projects into development based on adapting their animated classics into live-action films. However, as this article from Collider points out this project is one of the most interesting. That is because this project highlights what these live-action adaptions can be at their best, which is that the adaptation provide a different take on a story that Disney had already told. Instead of just turning the animated film into a live-action film. There is one thing that looms over this project that the other projects do not, Robin Williams. Whomever that Disney casts as in the role of Genie will have a huge shadow hanging over them. Disney will have to cast someone who on one hand has the comedic chops and, on the other hand, will not just do an impression of Robin Williams for 90 minutes. Nevertheless, I will be keeping an eye on how this project develops.


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Camp Life - Campus
US Golf Camps are held at the Elite Kiski School. Kiski, founded in 1888, is the oldest boys boarding school in the United States.
The large (350+ acres) campus is located Saltsburg, PA - near Latrobe.
There is a golf course on campus... EXCLUSIVELY for our campers!
Watch our Virtual Tour to see the rest of our campus.


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If Kris Humphries gets moved as part of the proposed monster trade for Dwight Howard, the Charlotte Bobcats would be interested in signing him to a one-year deal (which, it should be noted, Humphries' agent is strongly against.) Reports the Observer: "An NBA source confirms the Bobcats would be interested in Humphries, but only if he signs a one-season contract, rather than the multi-year deal he reportedly prefers. The Magic, Nets, Cleveland Cavaliers and Los Angeles Clippers are involved in complex talks that would involve multiple players and draft picks. Various reports have the Cavaliers accepting Humphries, in return for a future first-round pick from the Nets, in order to make a deal work under the salary cap. The Bobcats could take Humphries, but only if he's playing under a short-term deal, the source confirmed. Humphries, 27, averaged 13.8 points, 11.1 rebounds and shot 48 percent from the field last season. He's an unrestricted free agent but can make more per season re-signing with the Nets, even in a sign-and-trade, than signing outright with another team."
Charlotte Bobcats Reportedly Interested in Signing Kris Humphries


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Is Paper Mario Colour Splash Getting a Special Edition?
Paper Mario Colour Splash… has not exactly gotten a good reputation since it's reveal. From the hordes of negative votes and comments, to the #MakePaperMarioGreatAgain hashtag to endless angry videos about the game, it's basically gone down as well as a lead balloon.
But could the game be getting a special edition regardless? It seems so, since Amazon is listing the game as a 'standard edition'. Here's the wording from the page:
Paper Mario: Color Splash – Wii U Standard Edition
So what could this edition include? Well, usually special editions include stuff like Amiibo, art books, soundtracks, etc. Sometimes even a special limited version of the console too, as a sort of bundle deal.
Honestly, it's probably not going to be the latter. Why? Wii U is basically dead now. And even if it wasn't, the percentage of its audience who'll buy Paper Mario Colour Splash is… maybe about 10%. Its general reception, reputation and ties with Sticker Star could well cause it to bomb worse than Paper Jam did on the 3DS. Only a fool would sell a bundle with those odds for sales success behind it. An art book or soundtrack could be plausible, though the number of people that would care for concept art of 'generic New Super Mario Bros enemies in Paper Mario style' is another question.
Above: Maybe not the game that needs a special edition…
An Amiibo or Amiibo cards… well, that's the interesting possibility. What's more, the very gameplay concept revolves around cards. If there was ever a reason to include some special Amiibo cards in the box, well that's it. Scan in cards with special characters on the front, get more powerful attacks for in battle. Bit like in Paper Jam, except using new Amiibo as well as existing ones.
It could also be a mistake or reference to something else I guess.
But either way, there's now the possibility of a special edition version of Paper Mario Colour Splash. Are you buying it?


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This year I'm super happy that I went to Divisoria (168 Mall) to completed my Christmas shopping list. I went there 3rd Friday of November 2014, it's a good time to go, because there's only few people in the mall. Hindi mo kailangan makipagsisikan at tulukan. Convenient!
Mission accomplished! Gifts for inaanak (check), gifts sa mga mamasko sa bahay (check), gifts for nieces (check), clothes for me (check) at ang pinaka-importante sa lahat, pasok sa budget (check na check)!


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The local swim club is ready to make a splash.
No high school swimmers are competing at the state level from San Juan Island School District, but the island's Orcas swim club is ready to dive into their fall season.
Last year, Friday Harbor High School had two seniors, Tenly Nelson and Jocelyn Roberts, compete at the state's 2A level as part of the Anacortes school's team. They trained in Anacortes, as well at the San Juan Island Fitness pool, where the Orcas swim team practices and competes.
Though the club team is not affiliated with the national organization for swimming, the roughly 30 members will still compete in about four meets against other affiliated clubs in Anacortes, Lynden and Mount Vernon.
Tim Collins, the Orcas head coach for seven years, said he is most excited about "having lots of new swimmers on the team."
The swim club is comprised of youth from about age 7 to 18. They are divided into three groups, from beginners to advanced, named after the pods that the local Southern resident orcas live in: J, K and L.
Collins has swum competitively since age 12, as well as in college and afterward. He coached swim teams in Idaho and Maryland.
Collins said he is looking forward to watching the Orcas progress this year. He explained that the best part of being the Orcas coach is "seeing swimmers improve their strokes and becoming more confident in the water."
A fee is included to join the team, which has not been determined yet, this year. To learn more, contact San Juan Island Fitness at 360-378-4449.


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Annuities are contracts in which you trade money, or premium, to an insurance company in exchange for the promise of a stream of income. The stream of income can begin now (immediate annuities), or at some point in the future (deferred annuities). The rules for passing on annuities to future generations depend largely on whether the annuity has already begun generating income.
Minors and Inheritances
Minors cannot inherit money directly. If you want the money to benefit a child while the beneficiary is still a child, then you must set up a trust and appoint a trustee. The simplest way is via the Uniform Transfer to Minors Act, which can be done free — you just appoint a trusted, responsible adult to handle the money on the child's behalf.
Other Trust Options
It is possible to put some additional strings on the money, in order to encourage your child to engage in responsible behaviors. An attorney can assist you in setting up a trust that grants money to the child contingent upon graduating from school, remaining drug free or any number other milestones. There is a cost, however, to setting up these kinds of trusts.
Joint Life Annuities
For immediate annuities and annuities that have already begun disbursing income (that is, annuities that have been "annuitized"), the simplest thing to do, and perhaps the most tax-efficient, is to leave a joint life annuity to the child. That means that annuity payments will continue not only for the rest of your life, but for the child's life as well. This spreads the income over the longest period of time, maximizes the benefits of tax deferral, and puts the most amount of income possible into the lower tax brackets. Your monthly or annual payouts will be lower under a joint-life annuity, though, than they would be under a life-only annuity on yourself. However, this is a popular way to leave an annual birthday present or Christmas gift for children, long after a parent or grandparent is gone. Note that you can't leave a life annuity to a trust, since a trust is not a natural person and has no life span useful for calculating a life annuity.
Designated Beneficiaries
Annuities, retirement accounts and life insurance policies bypass probate courts and go directly to the named beneficiary — if there is one. Otherwise, the annuity becomes part of your estate and subject to probate, probate costs and delays. Be sure to name a designated beneficiary and contingent beneficiary on your annuity paperwork to avoid probate.
Photo Credits
- Child image by Serenitie from Fotolia.com


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01. June 2016
SIMON is the new, innovative exclusivity from SIGVARIS to help donning / doffing compression stockings. SIMON will noticeably improve your quality of life!
SIMON is your personal assistant for donning and doffing compression stockings for arms and legs.
You can use SIMON to don and doff your compression stocking quickly, effortlessly, and with very little exertion. It can even be used if you have limited mobility. SIMON is always there when you need it. It will accompany you on trips and can be easily stowed when it's not needed.


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The new trailer for "The Yellow Birds" is intense, setting up a mystery surrounding a missing soldier. Watch!
Alden Ehrenreich stars as Brandon, a soldier who comes home from the Iraq War without his close friend Daniel (Tye Sheridan). Now, he must face Daniel's grieving mother (Jennifer Aniston) and tell her the truth about what happened to her son. The film also features Toni Collette, Jason Patric, and Jack Huston.
"The Yellow Birds" will air exclusively on DIRECTV May 17 to June 13, followed by a theatrical and On Demand release by Saban Films on June 15.


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The Medical College Admission Test, or MCAT, is a multiple-choice standardized test required for admission to almost all medical schools in the United States and Canada. The test measures your knowledge of the physical and biological sciences as well as your ability to solve problems and think critically. If you decide not to take the test, you can cancel online.
Cancelling Your Test
Cancel your test by logging in to the MCAT Scheduling and Registration System and clicking "How to Cancel." You should receive a confirmation email within 24 hours of cancelling your test. You can also reschedule your test date or test center in the MCAT Scheduling and Registration System by clicking "How to Reschedule." Changing your test date or test center will cause you to incur additional fees.
Test-Fee Refunds
If you cancel your MCAT at least 14 days before your test date, you are eligible for a partial refund. If you paid the full registration fee, you will receive a $135 refund; if you did not pay the full registration fee, you will receive a $100 refund. Your refund will be automatically applied to your account. If you cancel your test within 14 days of the test, you will not receive a refund.


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I am trying to discover the best organic products for babies as you know. In one visit, my friend Neus from Barcelona brougth me this amazing cream… In theory it is a nappy cream but since my babygirl got a 2-months-chronic irritation and eczemas in her body I am using it everywhere on her! I remembered trying every cream from the apotheke, every recommendation from the doctor and nothing was working. Fortunately I was desesperate and I tried this cream in her body.. Wonderful.. it worked out and now every time she has some skin problem this is the only cream I am using.
After this miracle.. I am trying more products from this spanish organic brand.. Taller Amapola. Well done!!


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Time of the Writer 2013: Steinberg and Desai on "Writing the Other", Hassim and Molope on "Writing Gender"
Non-fiction authors Jonny Steinberg and Ashwin Desai, were quizzed on "Writing the Other" by facilitator Federico Settler at Saturday's session at the 16th annual Time of the Writer International Writers Festival.
Steinberg, most recently the author of Little Liberia: An African Odyssey in New York, is attached to the Centre for African Studies in Oxford, and winner of the Windham-Campbell Prize for Literature, was asked how his work differs from that of fiction writers. Steinberg answered that he "can't get into somebody else's head", but that he has to write from what he knows. He added that he "wouldn't presume to give voice to the other," but instead gets to know his interviewee very well, and "writes about that relationship".
Ashwin Desai, political commentator, explained that writing about interviews conducted in the place he calls home, Durban, was difficult in that "one can't escape one's own biography". He said in his book, Reading Revolution: Shakespeare on Robben Island, he wanted to talk about what happens when the "Calibans come to power" (referring to Shakespeare's The Tempest), noting that they often end up acting as "Prosperos".
Steinberg explained that when he tries to understand the people he writes about, he asks himself "how they feel about their own death". He explained that his forthcoming book, to be published early in 2014, focuses on a Somali man who led a "deracinated life in Somali, until he saved enough money to hitch-hike to SA, where he now runs a spaza shop in Blikkiesdorp". He noted that this man insisted on all the interviews he gave Steinberg being held in Steinberg's car, so that he could see "tsotsis" coming, if there were any, "in a way, trying to escape his own murder". This gave a sense of the xenophobic conditions under which he had to live, as opposed to Steinberg's relative safety as a white man.
At question time, a member of the audience asked Steinberg about Little Liberia, querying why there was a "muting of gender" in the text. Steinberg replied that he tends to sink more into the lives of the men he interviews, "perhaps because of projection and the ability to imagine myself in their shoes". He said however, that "one day I hope to write intimately about a woman". He said it was important for a writer not to speak over a reader's head, but to "trust your reader to be able to work out what you show him/her, which must be the guts of it, the story". He noted how one of his Liberian protagonists found it very traumatic to have sex with his wife for the first time, because she had undergone female circumcision. He then became virulently opposed to it. His wife however, supported the practice, and insisted on her daughters being circumcised too. "Swooping down on cultural practices from the outside doesn't work," said Steinberg, "it has to happen from the inside and outside at the same time".
Desai slated the rhetoric of post-colonial academics who analyse subaltern writing against the dominant discourse, saying it "doesn't get you closer to the magic". He said that interviewing people
for his book on Robben Island "humbled" him, although it didn't stop him from being critical. He noted that "research is a messy business".
A curiously vulnerable second session focused on "Writing Gender Violence". The tone was hesitant and yet determined.
Shubnum Khan, author of Onion Tears, said she believed domestic violence's power comes from "its secrecy and shame", and welcomed the opportunity to move the discussion from beyond the private confines of the home, to a more public sphere. Shafinaaz Hassim read from her recently published book Sophia, a novel about domestic violence, followed by Kagiso Molope who read from her novel about rape, called This Book Betrays my Brother. Hassim said she chooses to write about violence because she's a sociologist researching the issue, but wants to unpack these stories "not scientifically, but for a broader audience". Molope said she grew up in a violent township where she witnessed many attacks on women, and always "wanted to write about the role of the witness. Do you speak out? Make excuses for the men?"
Khan asked the authors to comment on why victims who endure trauma often are further victimised. Hassim said she believes this comes from a "pseudo self-righteous culture of denialism", where "it has become acceptable to blame the victim for her abuse," so that she can then be "punished / disciplined / fixed". Molope said in her book the brother accused of rape rejects his sister when she tries to talk to him about what has happened: and then he excludes her from his community, revealing that her challenge has become a threat for an entire group, not just an individual.
Khan mentioned several high-profile rape/assault cases that have appeared in the media lately, for instance, the rape and murder of Anene Booysen in the Cape, and the shooting of Oscar Pistorius's girlfriend Reeva Steenkamp. Hassim said that it is reassuring that there is a renewed consciousness around gender violence, because it is important that civil society fights back. Molope said, from what she has gathered from talking to township people, women in SA are "under siege", they feel that there is a civil war against them and children.
An audience member asked Hassim whether she believes fiction can be a form of self-help. She said she lent Sophia to someone in an abusive marriage, who chose not to leave. Hassim said perhaps it was too early to see her action as a failed attempt. A man from the audience asked the authors whether they thought a man could write about gender-based violence. Molope said she believed one needs to include "many perspectives". Another question focused on whether violence can have emancipatory possibilities. Molope said we can't dictate how victims respond to violence, while Hassim mentioned a movie she saw about an Indian woman who burned her abusive husband to death in a house fire. Molope said it is always a victim's choice to react in a certain way, but "you owe it yourself to just be you".
Centre for Creative Arts co-ordinator, Tinso Mungwe, then wrapped up the festival with a vote of thanks for the organisers, funders, and authors.
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- Little Liberia: An African Odyssey in New York by Jonny Steinberg
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- Reading Revolution: Shakespeare on Robben Island by Ashwin Desai
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- Onion Tears by Shubnum Khan
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Practical manual switchCan be operated via a practical manual switch. Integrated holderThe manual filling head can be stored in an integrated holder. Hygienic designRapid and easy cleaning thanks to tool-free disassembly and use of low-pressure equipment
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July 27 Philadelphia Daily News
A new era of Eagles football is here, and ready or not, all eyes are on the fourth-year quarterback expected to lead a young, unproven squad into 3 weeks of training camp in the rolling hills of the Bethlehem campus. It all starts with 8:45 a.m. and 3:30 p.m. practices for rookies and selected veterans today.
No one will be under more watch than Kolb, who was handed the reins of the offense this offseason when the Eagles dealt 11-year signal-caller Donovan McNabb to the Washington Redskins.
"I've been thrown into situations throughout my career, and I've always just leaned back on playing football, and that's what I'm gonna do here," Kolb said. "I don't want to get too caught up in trying to fill Donovan's shoes or being the quarterback of the Eagles. I just want to play the game that I know how and distribute the ball to the athletes that are around me."
It's exactly what coach Andy Reid will be looking for during camp. Comfortable enough with Kolb to reshuffle the look of the franchise, Reid said his new quarterback is further along in development than when McNabb was a first-year starter.
Reid wouldn't rule out playing Kolb more in the preseason games, but that depends on the coach's satisfaction with his progress.
Knowing a hiccup or two from Kolb is inevitable along the way, Reid is "fired up" to coach his young team and see where it winds up.
"There's a little bit of an unknown, which I kind of like," Reid said. "I like that. I think it's a great challenge. It's a great challenge for the coaches and for the players. There's some big-name players that have been proven players on this football team, that aren't here. It's important that the young guys step up and they go. That, to me, is exciting."
That starts with Kolb.
Playmaking, skill-position players aren't in short supply with LeSean McCoy in the backfield, DeSean Jackson out wide and tight end Brent Celek as a security blanket underneath.
The success of the offense figures to come from cycling through the right reads and having protection up front to deliver the football.
"This is as important as it gets for us," Kolb said of training camp. "We're a young team. We have to build a little more rapport, but there's a lot there to build off of. Plenty of talent, all it takes now is hard work, and we're definitely gonna do that part of it.""


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Registration for the 2016 Mystic MTB Race on July 16 is now live! Click the button below to sign up!
Author: lowrysteve3
Race Results!
We want to thank all of the racers and especially the volunteers who helped make this event great for a second year in a row. We also want to thank our presenting sponsor Owenhouse Cycling, and our supporting sponsors Outside Bozeman Magazine, Bozeman Brewing, Oboz Footwear, Rockford Coffee, Rocky Mountain, and Ibis. See you all next year!
Registration is Live!
We are happy to announce registration for the 2015 Mystic MTB Race is now open. Click here to register.
Packet Pickup
We hope that you are all having a great summer and training is going well. The field of racers is growing by the day. We want to let everyone know that there will be a mandatory race packet pick up on Friday July 18th 3pm to 7pm at Owenhouse Bike Shop
This should give everyone a chance to pick up any last minute parts or gear and check out the store's new remodel. Racers will also be signing waivers and picking up numbers at this time, but will still be required to check in the morning of the race to confirm who we have on the course.
It looks like the weather is finally changing and the trails are drying out, so get outside and get riding! We can't wait to see you all July 18th!
SL and RK


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A Bus Hangs on Top of a Hong Kong Five-Star Hotel
British artist and sculptor Richard Wilson hangs a life-sized bus on the edge of Hong Kong's Peninsula Hotel. The WSJ's Dean Napolitano has more. Photo: Karan Deep Singh for the Wall Street Journal.
This transcript has been automatically generated and may not be 100% accurate.
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MDedge Infectious Disease Editorial Staff
Editorial Management
Denise Fulton, executive editor, Medical News Division, joined the company in 2000, editing Family Practice News and Skin & Allergy News prior to her current position. She covered health policy for a national advocacy group for 12 years and served as a staff member in the 100th Congress. Denise earned her Bachelor of Science degree from the Perley Isaac Reed School of Journalism at West Virginia University
Kathy Scarbeck, executive editor, Medical News Division, has had editorial oversight of the wire service since its launch in 2006. In her 20 years with the company, Kathy has worked as a reporter, editor, and editorial manager of web and wire service products. She graduated magna cum laude with a Bachelor of Arts degree in English from the University of Notre Dame and a Master's of Arts degree in Journalism from Indiana University. Connect with her via LinkedIn.
Web Team
|Doug Brunk is an award-winning reporter who has been covering health care since 1991. Before joining the company, he wrote for the health sciences division of Columbia University and was on the editorial staff at Contemporary Long Term Care magazine when it won a Jesse H. Neal Award. He has a master's in magazine journalism from the S.I. Newhouse School of Public Communications at Syracuse University. Doug is based in San Diego.
Alicia Gallegos is an award-winning journalist who has covered health care, physician trends, and medical liability for more than 10 years. She reports on practice economics, medical malpractice, and legal trends for Frontline. Prior to joining the company, Alicia wrote about medicolegal issues for American Medical News, the newspaper of the American Medical Association. She launched her journalism career at the South Bend Tribune, where she covered a range of topics including health, food safety, and criminal justice. Her work also has appeared in the ACP Hospitalist, ACP Internist, AAMC Reporter, and Michigan Medicine magazine. She is based in the Midwest Bureau. Follow Alicia on Twitter @legal_med.
Bruce Jancin has brought our readers news of the major medical developments for more than 30 years. Bruce covers medical research and continuing education meetings around the world and is based in Denver.
Kari Oakes joined Frontline Medical Communications as part of the Midwest bureau in 2015. In addition to covering major medical conferences for a number of clients and working as an academic editor, she has been a practicing physician assistant in family medicine, emergency medicine, urgent care, and neurology. She has a Bachelor of Arts degree in English and philosophy from St. Norbert College in DePere, Wisconsin, and has a degree in physician assistant studies from the University of Wisconsin-Madison.
M. Alexander Otto began his reporting career covering the pharmaceutical industry for a national pharmacists' magazine and freelancing for the Washington Post and other newspapers. He then joined BNA, now a part of Bloomberg News, covering health law and the protection of people and animals in medical research. Alex next worked for the McClatchy Company, a major newspaper chain. Based on his work, Alex won a year-long Knight Science Journalism Fellowship to the Massachusetts Institute of Technology in 2008-09. He joined Frontline shortly thereafter. Alex has a newspaper journalism degree from Syracuse University and a master's degree in medical science -- a physician assistant degree -- from George Washington University. Alex is based in Seattle.
Michele G. Sullivan has been a reporter and editor for more than 25 years. In her career, she has won 32 state and national awards for feature, news, and editorial writing and for newspaper design. As part of Frontline Medical News's Mid-Atlantic bureau, she received the Journalism Fellowship Award from the American Academy of Neurology in 2007 and a Gold Triangle Award from the American Academy of Dermatology in 2010.
Gregory Twachtman is a Washington-based reporter covering health policy and economic trends. Prior to joining Frontline Medical Communications in April 2014, Gregory spent nearly eight years covering pharmaceutical reimbursement, comparative effectiveness research and health information technology at "The Pink Sheet." He has been a reporter for more than 17 years, covering a wide variety of topics, including wireless and satellite telecommunications, commercial nuclear power and the commercial airline industry. Gregory graduated in 1996 from St. Joseph's College, Patchogue, N.Y., with a Bachelors of Science in accounting.
Sharon Worcester is an award-winning reporter who has been covering health care since 1992. She first joined the Southeast bureau in 1996 after working as a daily newspaper reporter covering government and health, and spent the next 13 years covering medical research and continuing medical education meetings across the country and around the world. She rejoined the company in 2015 after a 5-year stint as a freelance reporter and writer. She has a master of arts degree in mass communication and print journalism from the University of Florida, Gainesville. Sharon is based in Birmingham, Alabama.
Mitchel L. Zoler joined the company's Philadelphia bureau in 1992 and since then has covered more than 300 medical research meetings around the world. Previously, he covered medicine and science for publications including Medical World News, Cardiology Times, Urology Times, Hospital Practice, and Science Digest. A fellowship through the American Association for the Advancement of Science landed him at Newsweek early in his career. Mitchel has a Ph.D. in microbiology and did post-doc work in virology. Follow him on Twitter @mitchelzoler.
Senior Editors
Multimedia Producer
Editorial Production Manager
Multimedia Editor
Associate Editors
Contributing Reporters
Nancy Baron is a freelance reporter based in Holliston, Mass.
Last updated October 10, 2019


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The coolest monster mask of all time --- The Shock Monster celebrated! Mad Monsters, The 1950s Sci-Fi world we never saw, TV Horror Host Dr. Paul Bearer, The Cosmic Drive-In, Famous Forry Fotos, Resurrecting the great "Calendar Masks," Coverage of Monster Bash 2002 and much more! IT THE TERROR FROM BEYOND SPACE, THE MUMMY'S CURSE with Virginia Christine, Monster Comics, The secret world of The Old Dark Clubhouse....the issue is jam-packed!
Click To Enlarge
- Manufacturer: Scary Monsters


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Interfaith prayers! NC Priest, Rabbi, Imam
Apologies for all offended, just reporting the news….
The Interchurch Center in New York is rededicated after its first 50 years
See: www.ncccusa.org/news/100526ticrededication.html
New York, May 26, 2010 — The Interchurch Center in New York's Morningside
Heights, once envisioned as a "Protestant Vatican on the Hudson," has evolved
over fifty years into an interfaith, multi-ethnic community of non-profit,
educational and church agencies.
That may not be what the planners expected, but it turned out "very good,"
said the Rev. Dr. Michael Kinnamon, General Secretary of the National Council
of Churches…..
An interfaith trio offered the call to worship: Father Robert George
Stephanopoulos, Greek Orthodox Archdiocese of America; Rabbi Marcus L.
Burstein; and Imam Feisal Abdul Rauf. Lois M. Dauway, a member of The
Interchurch Center board, led a responsive reading.
The Most Rev. Katharine Jefferts Schori, Presiding Bishop and Primate of the
Episcopal Church, led a litany of remembrance and rededication.
The Lord's Prayer was led by the Rev. Dr. Kermit J. DeGraffenreidt,
Secretary-Editor for the African Methodist Episcopal Zion Church and a former
member of The Interchurch Center board.


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News & Events
News Archive
2018 News
Community Garden registration runs Feb. 15 – March 15
Community Garden registration runs Feb. 15 – March 15
January 26, 2018
Spring is just around the corner, so Johns Creek gardeners can begin signing up for a chance to land a plot at Johns Creek's Newtown Park Community Garden.
Johns Creek gardeners can begin signing up for a chance to reserve a plot Feb. 15 through March 15 by submitting their applications to the Johns Creek Garden Association. To be eligible for a spot, one must be a resident of the City of Johns Creek and become a member of the Johns Creek Garden Association. Membership costs $10 annually.
The Community Garden offers 52 plots in which people can grow vegetables and flowers. Community gardens are popular among people with little or no space for gardens. The garden has four raised beds for those who have trouble working at ground level. Each plot is 4 feet by 8 feet.
A garden plot applications fee is $60 and seniors over 65 pay $25. Membership and application fees are refundable for people not selected for a plot. Applications can be downloaded from the
Garden Association website
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Hastings & Rye nominees elected to Labour Party National Executive Committee
The six candidates nominated by the Hastings & Rye Labour Party for the National Executive Committee of the party have all been elected. They are Ann Black (100,999), Christine Shawcroft (97,510), Claudia Webbe (92,377), Darren Williams (87,003),Rhea Wolfson (85,687),Pete Willsman (81,863).
Full results can be found by clicking on this link.


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The Path to Protection
Clinical trials both past and present are contributing to the design of new and improved HIV vaccine immunogens
By Seema H. Bajaria
Larry Corey, who stepped down as president and director of the Fred Hutchinson Cancer Research Center (FHCRC) in June (see Back to the Bench, this issue), set the tone for the opening day of this year's Full Group Meeting of the HIV Vaccine Trials Network (HVTN), which was held in Washington, DC, from June 3-5, when he deemed the general mood of vaccine researchers as "optimistic." Five years have passed since the surprising results of the RV144 trial—the first to provide any evidence of vaccine-induced protection against HIV. And while researchers are still interpreting its aftermath, other areas of investigation are also advancing.
The first day of the HVTN meeting centered on four plenary sessions that covered research highlights in the areas of immune correlates, non-human primate (NHP) models, broadly neutralizing antibodies (bNAbs), and ongoing Phase I clinical trials.
Immune correlates
The ongoing immune correlates analysis of the RV144 trial, the subject of the first plenary, has so far centered largely on antibodies. Researchers have shown that plasma immunoglobulin (Ig)A antibodies to HIV Env in vaccine recipients are directly correlated with an increased risk of HIV infection, making them what researchers refer to as a correlate of risk; whereas IgG antibodies directed to the V1/V2 regions of HIV Env have been inversely correlated with infection risk (NEJM 2012, doi: 10.1056/NEJMoa1113425).
While it did not appear that the total frequency of antigen-specific T cells had a significant effect on HIV infection risk, researchers hypothesized that there were functional characteristics of the T cells induced by the RV144 vaccine that were protective for certain individuals. And it turns out this is the case. Greg Finak, staff scientist at FHCRC, presented data from a combinatorial polyfunctionality analysis (COMPASS) method that indicates polyfunctional T-cell responses are indeed independent correlates of infection risk in RV144. Further work is required to better understand this data, but one possible hypothesis Finak suggests is that multifaceted T cells could be the "help" that B cells require to be effective.
Researchers are also conducting sieve analyses of RV144, comparing the breakthrough virus sequences in vaccine and placebo recipients. This helps determine what effect immune pressure exerted by the vaccine had on selectively blocking, or sieving, the infecting virus, as well as on evolution of the virus after acquisition. Paul Edlefsen, a biostatistician at the Vaccine and Infectious Disease Division of the FHCRC, followed up on prior reported results of the significance of antibody-mediated immune pressure at amino-acid positions 169 and 181 (signature sites) in the V2 region of HIV Env (Nature 2012, doi: 10.1038/nature11519).
Researchers have also used a more expansive analysis to identify evidence of T-cell mediated pressure in regions of Gag and Pro that were included in the vaccine, and provide data that genetic differences occur outside of those immunogen regions. Volunteers who became HIV infected despite vaccination tended to have a higher level of phylogenetic divergence in Gag, a finding consistent with what was seen in volunteers in the Phambili (HVTN 503) trial, and reminiscent of the T-cell epitope divergences seen in volunteers in the STEP (HVTN 502) trial, both of which tested Merck's MRKAd5 HIV gag/pol/nef trivalent vaccine candidate that failed to provide any protection.
Susan Zolla-Pazner, professor of pathology at New York University, compared two signature sites that Edlefsen and others identified in the V3 region of Env, with the two previously identified V2 signature sites. She found that position 307 in V3 and position 169 in V2 are similar in that both indicate the vaccine was able to protect against viruses with amino acids matching those in the immunogen. Zolla-Pazner presented evidence that these signature sites are both contact residues for vaccine-induced antibodies.
By contrast, position 317 in V3, which is similar to position 181 in V2, are both sites at which immunogen-matching residues are more frequently conserved in vaccine-recipient breakthrough viruses. Zolla-Pazner hypothesized that rather than directly impacting antibody binding, mutations in these residues reduced viral fitness and infectivity, and were thus more conserved in HIV sequences that were able to infect vaccine recipients despite the presence of antibodies targeting sites such as position 307 in V3 and 169 in V2.
NHP models
The second session of the day focused on identifying what immune responses might be required for protection using NHP studies. Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, is examining the earliest events during the so-called eclipse phase of infection, which is the time between virus inoculation and the first appearance of virus in plasma, including the pathways of virus spread and the host response, which are still poorly understood following intra-vaginal (IVAG) infection in rhesus macaques.
During IVAG infection with simian immunodeficiency virus (SIV)mac251, data show that the virus may breach the mucosal barrier as early as the first day following infection, followed quickly by systemic virus dissemination. While analyses are still underway, virologic data show that on the first day after infection, occasional lymphoid and gastrointestinal tissues tested positive for virus. Both CD4+ and CD8+ T-cell responses first appeared locally in the mucosa, but not until seven days post-infection, with systemic T-cell responses lagging even further behind, echoing earlier findings. Therefore, Barouch concluded that the eclipse phase is dynamic and complex, with virus broadcasting to distal tissues within the first few days of infection. His group now plans to use this NHP model to interrogate how neutralizing antibodies and vaccines protect and precisely when and where they might intercept the trajectory of virus spread following viral challenge.
Richard Koup, chief of the immunology laboratory at the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), also spoke about using NHP models to understand the development of bNAbs. Koup showed that during chronic SIV/HIV chimeric virus (SHIV)-AD8 infection of eight monkeys, bNAbs develop slowly in the germinal centers and are associated with Env sequence diversity, both the quantity and quality of Env-specific TFH cells, and the quantity of Env-specific B cells in the lymph nodes.
Based on these observations, Koup concluded that antigenic changes will be required for Env immunogens to drive the degree of somatic hypermutation required for the development of bNAbs, and he thinks NHP studies can be effectively used to inform the design and efficacy testing of different Env immunogens.
Neutralizing antibodies
The focus on bNAbs continued with a presentation by John Moore, professor of microbiology and immunology at Weill Cornell Medical College. He described the work of a team that, as reported previously, has produced a stable trimer structure, BG505 SOSIP.664, that is able to bind multiple bNAbs (see CROI: Progress on Prevention and Cure, IAVI Report, Vol. 18, Issue 1, 2014). Pooled data from two rabbit studies shows that this trimer structure induces antibodies that neutralize the autologous tier-2 virus, as well as more sensitive, but less relevant, heterologous tier-1A and tier-1B viruses. In these studies, Moore found that induction of tier-1 NAbs, which are predominantly directed to the V3 region of gp120, is not predictive of the induction of tier-2 NAbs. Moore suggested it is possible that tier-1 NAbs may even distract from or interfere with the induction of antibody responses against tier-2 viruses, which should be the goal of vaccine design strategies.
Future experimentation on this point seems justified, Moore said, while emphasizing that much work remains to be done to devise immunization strategies that might lead to the induction of cross-reactive tier-2 bNAbs with properties similar to those found in about 20% of HIV-infected individuals. New immunization and trimer design strategies could include cocktails of SOSIP trimers from the same or different subtypes, according to Moore, as well as the application of structure-guided improvements that are now being explored in the team's laboratories. A consortium including the International AIDS Vaccine Initiative, the Bill & Melinda Gates Foundation (BMGF), and the Center for HIV/AIDS Vaccine Immunology-Immunogen Design (CHAVI-ID) has been established to create BG505 SOSIP.664 trimer cell lines by the end of this year, with the aim of testing this trimer in humans. New and improved SOSIP trimer candidates will also yield additional immunogens for testing in animals in the coming year, Moore said.
Leonidas Stamatatos, scientific director at the Seattle Biomedical Research Institute, continued the discussion of Env immunogens as he described his efforts to elucidate why the generation of narrowly neutralizing antibodies (nNAbs) is more predominant than bNAbs. To understand how most recombinant Envs activate only those B-cell receptors (BCRs) that induce nNAbs, Stamatatos stressed the importance of understanding dynamics within the germinal centers where high affinity B cells are selected. As HIV has evolved to avoid detection by B cells that express BCRs giving rise to bNAbs, trimers that avoid recognition by nNAbs are necessary to elicit antibodies with broadly neutralizing capability, according to Stamatatos.
Phase I program
While immunogen development in the laboratory continues, others are already evaluating different antibodies, vectors, and immunogens in clinical trials.
Mark Connors, chief of the HIV-specific immunity section at NIAID, provided an update on the need for small, flexible clinical trials to evaluate which immunogens drive B-cell somatic hypermutation and T-cell cytotoxic capacity, including the testing of Ad4-based HIV vaccine candidates. In a Phase I clinical trial, an Ad4 vector-based H5N1 influenza vaccine was well tolerated and induced neutralizing antibodies and somatic hypermutation (Lancet Infect. Dis. 2013, doi: 10.1016/S1473-3099(12)70345-6; and other unpublished observations, according to Connors), making Connors optimistic about the potential for an Ad4 vector-based HIV vaccine to also induce neutralizing antibodies.
He and colleagues are now evaluating the immunogenicity of replicating Ad4 vectors in humans, including an Ad4-mGag (designed to induce T-cell responses) and an Ad4-EnvC150 (designed to induce antibody responses). This Ad4-HIV trial, which began in January, is part of a long-term collaboration between NIAID, NIAID's Division of AIDS (DAIDS), and the biotechnology company PaxVax, Inc.
Meanwhile, Marina Caskey, assistant professor of clinical investigation at Rockefeller University, and colleagues are evaluating the direct administration of two monoclonal antibodies, 3BNC117 (directed to the CD4 binding site) and 10-1074 (directed to the V3 region of HIV Env), discovered by Michel Nussenzweig's laboratory at Rockefeller. Based on the initial success of certain doses of 3BNC117 and 10-1074 to prevent virus acquisition in NHPs, as well as transiently decrease viremia in chronically infected macaques (Nature 2013, doi: 10.1038/nature12746), a Phase I dose-escalation study to evaluate the safety, pharmacokinetics, and antiretroviral activity of 3BNC117 began in February. Two other anticipated Phase I studies include a dose escalation, safety, and pharmacokinetics study of 10-1074 and a safety study of 3BNC177 and 10-1074 combined. Future studies could evaluate the efficacy of 3BNC117 or 10-1074 to prevent acquisition of HIV, as well as to treat chronically HIV-infected individuals during antiretroviral therapy interruption or in addition to traditional antiretroviral therapy.
Lastly, George Lewis, co-director of basic science and vaccine research at the Institute of Human Virology, discussed progress in developing full-length single chain gp120-CD4 complex Env immunogens. Data from five completed NHP protection studies will be published soon, according to Lewis, and a Phase I trial is slated to begin by early next year in collaboration with several partners, including Profectus Biosciences, the US Military HIV Research Program, DAIDS, Sanofi Pasteur, the National Institutes of Health, and BMGF.
Seema Bajaria reports on infectious diseases, systems biology, and public health and is based in New York City.


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Hurt Feelings
—When We Have "Cause for Complaint"
"A sister in my congregation wrongly accused me of stealing money from her. Others in the congregation learned of it and began to take sides. Eventually, the sister told me that she had received some new information that exonerated me. Although she apologized, I felt in my heart that I could never forgive her for what I had gone through."
CAN you relate to Linda, who was deeply hurt by the actions of a fellow believer? Sadly, some have been so disturbed by the conduct of others that it has affected their spiritual routine. Has that been true in your case?
Can Anyone "Separate Us From God's Love"?
Admittedly, we may find it very difficult to forgive a fellow believer who has hurt us. After all, Christians should love one another. (John 13:34, 35) If we have been wronged by a fellow believer, the disappointment and pain can be devastating.
Of course, the Bible acknowledges that there are times when Christians give one another "cause for complaint." (Colossians 3:13) Even so, when that happens to us personally, we may find it to be quite a challenge to deal with. Is there anything that can help us? Consider three Scriptural principles:
Our heavenly Father is aware of everything. Jehovah observes all that happens, including any injustice we face and the suffering it causes. (Hebrews 4:13) Moreover, Jehovah feels for us when we suffer. (Isaiah 63:9) He never allows "tribulation or distress" or anything else
To forgive is not to condone. When we forgive those who have wronged us, we are not minimizing, justifying, excusing, or condoning their actions. Remember, Jehovah never approves of sin, but he does forgive it if there is a basis for doing so. (Psalm 103:12, 13; Habakkuk 1:13) When he encourages us to forgive others, Jehovah is asking us to imitate him. He does not "stay resentful forever."
When we let go of resentment, we benefit ourselves. In what way? Imagine the following scenario. You pick up a rock, perhaps one that weighs just a few pounds, and hold it at arm's length. You would probably have little trouble holding the rock for a short time. But what if you tried to do so for an extended period of time? How long would you be able to hold it
"I Felt as if Jehovah Himself Was Talking to Me"
What helped Linda not to harbor resentment over the way she had been treated by a fellow believer? Among other things, she meditated on Scriptural reasons to extend forgiveness. (Psalm 130:3, 4) Linda was especially moved by knowing that when we extend forgiveness, Jehovah will, in turn, be forgiving toward us. (Ephesians 4:32–5:2) Regarding how those sentiments affected her, she says: "I felt as if Jehovah himself was talking to me."
In time, Linda was able to let go of resentment. She freely forgave the sister, and now that sister is her dear friend. Linda has moved forward in her service to Jehovah. Be assured that Jehovah wants to help you do the same.


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Known for his erotic and highly decorative style of painting with the primary subject being the female body, the Austrian symbolist painter Gustav Klimt was born 150 years ago today, and thanks to Google, a lot of people now know who he is.
On the occasion of Klimt's 150th birth anniversary, Google has come up with a doodle that is dedicated to the artistic painter and has featured it on its home page by replacing the Google logo with the doodle. The doodle reflects one of Klimt's most famous work – "The Kiss," which he painted between the year 1907 and 1908.
The doodle has the letters "Google" in golden-yellow color placed in the background, while the painting "The Kiss" is placed over it.
Not many knew about the Austrian painter until Google put up the doodle, although he was referred to as an important artist and had gained worldwide recognition even beyond the art world during his time.
On this day, Austria will be celebrating Klimt's birthday with special exhibitions in and around the city, including a few guided walking tours where people will be guided through some of the places and building where Klimt worked. Also, to coincide with the birth anniversary of Klimt, the Austrian Mint had begun a 5 coin gold series in 2012, and issued the first 50 Euro gold coin on January 25, 2012, featuring a portrait of Klimt.
Klimt's painting stirred lot controversies during his time because of his celebration of sex and sexuality. However, today, Klimt's works are among the world's most expensive available, and "The Kiss," featured in today's doodle is his most famous painting. Klimt also made it into the headlines last year when one of his paintings was sold at an auction for nearly $40 million.
|Born:July 14, 1862, Baumgarten, ViennaDied:February 6, 1918, Vienna
Education: University of Applied Arts Vienna (1876–1883)
Parents: Anna Klimt, Ernst Klimt the Elder
Children: Otto Zimmermann, Gustav Ucicky, Gustav Zimmermann
With all this, some Internet users had deliberately changed the Klimt's Wikipedia page, in which the first line read as, "Google, the worst search engine, has made a link to Gustav Klimt…" However, this appears to be fixed as you can see the last modified timestamp at the bottom of the page.
Klimt died in Vienna on February 6, 1918 after contracting Spanish flu during the 1918 flu pandemic.


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So what ever you want from your holiday, to just relax poolside with a cool drink or to explore the island, Villa Eden is the ideal location for all.
Hope to see you soon!


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By Ralph Peters
Published December 01, 2016
I'm lucky enough to know General James Mattis slightly. Just well enough to trust him unreservedly with our military and our nation's security.
The president-elect could not choose a better man to be our next Secretary of Defense. Not just because Mattis is a battle-hardened Marine with a remarkable combat record. And not just because he has a mind of remarkable clarity and is, without question, the best-read general of his generation.
I trust Jim Mattis because he's a man of character, that most un-Washingtonian quality. His public image is of one rough-and-tough Marine, but the man I've encountered is, above all, one of integrity. His code of honor is so out of fashion that one has to reach back to a Victorian vocabulary: He has a noble spirit.
And he's a genuine patriot, not a shouter with his eye on the next chance. He will do what's right, not what's expedient. And he will never go along with anything he believes might harm our country.
In addition to plenty of dirty-boots experience in the Middle East and a deep knowledge of history—that most underrated study—Jim Mattis has another great qualification to be SecDef: He wasn't looking for a job. He was happy in retirement, studying, helping his fellow Marines, and contributing thoughtfully to our national security behind the scenes.
The last time I heard from him—a bit before the election—he mentioned, not for the first time, that he was glad to be west of the Rockies. A Washington, D.C. post was not part of the plan; rather, he thought of farming in rural Washington State.
This matters. In an age of sycophants and clawing ambition, it's a splendid prospect to have a classic patriot who's willing to sacrifice to serve (as Jim Mattis already has for four decades in uniform).
Our most underrated president of the last century, Dwight D. "Ike" Eisenhower, didn't want anyone in his cabinet who actively sought the position. He wanted successful men from various walks of life who would have to leave successful careers and contented lives to come to Washington and run a department ethically (an earlier version of "draining the swamp").
For General Mattis, the position of Secretary of Defense wouldn't be just another inside-the-Beltway badge to add to his resume. The greatest danger would be that he would prove too honest for D.C.
Yet another quality Mattis would bring to the office—a vital one—is that he's a superb listener (yet another rare quality in Washington). He's not quick to speak, but when he finally does have his say, his words show command of the subject under discussion. And he uses words with the same economy as a rifleman uses bullets: no wasted rounds.
As a member of the Hoover Institution's Military History Working Group, he'd listen to the rest of us blather on for hours before saying a word. Then he would succinctly, politely and irrefutably explain why we had no idea what we were talking about.
What would the nation get with General James Mattis as Secretary of Defense? Integrity. Deep knowledge. Courage, both moral and physical. Humility. Decency. Vision. A steely sense of duty. Fiscal responsibility. A natural leader of men.
In short, character.
Inevitably, we've heard plaints from the left about the "danger" of generals in high government positions, with the suggestion that they'll take us into wars. But it hasn't been the generals who've gotten us into our recent conflicts or who have failed to resolve them. For the last sixteen years, we've seen civilians with no military experience launch ill-considered wars and impulsive interventions without considering the second- and third-order effects. Generals, by contrast, are reluctant to send our troops to war—they know the complexity and the cost.
General Mattis has a long list of military accomplishments, but I suspect that one of the experiences that cut deepest came in 2004, in Fallujah. After a week of brutal, successful combat his Marines stood within forty-eight hours of a clear-cut victory over a terrorist army. And the Bush administration lost its collective nerve, calling a halt just short of the finish line. I watched the tragedy unfold from northern Iraq, where I was a guest of the Kurds. And we all said the same thing to each other: "We'll have to go back and finish this." And we did have to go back, in less than a year.
Having seen his Marines die, only to be denied victory at the eleventh hour because the global media was howling, must have been terribly painful for General Mattis. One of the many reasons he's so widely respected in military circles—not just by Marines—is that he understands that, contrary to academic pronunciamentos, victory is not only possible, but essential.
Jim Mattis not only fights the good fight—he fights to win. With him as our next Secretary of Defense, the United States of America would win.
Fox News Strategic Analyst Ralph Peters is a retired U.S. Army officer and former enlisted man. He is the author of prize-winning fiction and non-fiction books on the Civil War and the military. His latest is "The Damned of Petersburg: A Novel" (Forge Books, June 28, 2016).
Views: 696
We would get a strong military.
And a strong nation.
Finally our troops will not have to check with a P.C. lawyer at the Pentagon before they can return fire...This Nam vet can't stand politicians who get us in a war and then hamstring our ability to win.
Ooh-RAH! Mistakes might happen, but it's WAR; God will sort things out! "New ROE, Marines, and only one; all others are now null and void: 'If it moves, it's a target.' That is all. Dismissed."
Ed, Da Nang, 1968
To Ed and all the Vets THANK YOU FOR YOU SERVICE! I can't say that enough. Ed you are right about the ROE. I'll take it one step further. If it smells it's a target.
President-elect Trump has nominated him and there does not appear to be any objection, at least not of consequence..........so General Mattis should be our next Sec Def...........and yes, it is refreshing and exactly what we need.
Colonel, we might just get the CINC back into our military!!
Fred Ward, Viet Nam, 62, 68, Laos 73-74
Counting on it Fred..........
Well, you can't get a better endorsement than that!!
This makes me feel a whole lot better, now if we could only prevent the elites from sending our Country into a financial collapse...they are in control of our stock market and could really cause chaos in America. Everything shut down in a heartbeat if the market collapses and banks close. I think we are going to need a good military to protect this Country as well.
I have a seatbelt on my chair...ready for President Trump's first 100/200 days as POTUS.
I thank GOD for this wise selection.


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By Jordan Poll January 9, 2017
As the Trans-Pacific Partnership (TPP) has become a subject of national attention, the effectiveness of international investment agreements (IIAs), particularly bilateral investment treaties (BlTs), also has been in the spotlight. One of the more controversial aspects of the TPP allows foreign investors to take the United States to court outside of the U.S. legal system, causing many to argue that such an arbitration mechanism hinders U.S. BlTs from functioning as they were originally designed—to protect the United States and its native investors. In response to the increased attention drawn to BlTs, the United Nations Conference on Trade and Development (UNCTAD) initiated the IIA Mapping Project to better understand the trends in IIA drafting.
"Bilateral investment treaties grant protections to the investors from one country who are investing in the other country that is party to the treaty. They are designed to make locations that are risky to invest in, less so, in order to promote investment and economic growth," explained Cree Jones, '13, who was first introduced to BlTs in 2011 during his internship with the U.S. Treasury's Office of International Affairs in Washington, D.C. Since that time, Jones's interest in international economics—specifically BlTs—has led him to be intricately involved in the mapping of these treaties with UNCTAD.
Jones's relationship with UNCTAD began his second year of law school. After having secured a summer internship with the IIA Section, Jones was able to work alongside staff to map BlTs. At that time, UNCTAD mapped all BlTs internally, which made progress incredibly slow—only a handful of BlTs being completed at a time. Seeing a need for change, Jones began making plans that would not only speed up the mapping process but would also create a meaningful educational experience for students around the world. As his internship drew to a close, Jones proposed the idea that he had been piecing together all summer. He called it the
UNCTAD University IIA Mapping Project.
The central premise of the University Mapping Project lies in the UNCTAD bringing universities in on the mapping project—essentially outsourcing what was once an internal effort. Jones argued that it would not only be beneficial for staff, who had other responsibilities to juggle, but it would also be a great learning opportunity for postgraduate or PhD students interested in the field of international and economic law. "There is a substantive impact on students involved in this project, in being introduced in a really concrete way to this area of law," said Jones, who had experienced this impact firsthand during his summer internship with the IIA Section. "They also have the opportunity to collaborate on a global level." Jones proposed that while the IIA Section would coordinate and oversee the work being done, the mapping of each treaty would be run by two students who would choose their partner across universities. Together these students would read their assigned text and, using a 90-page instruction manual provided by UNCTAD, document the inclusion and variation of 150 different provisions. They would enter the information into an Excel table to later be reviewed and submitted into the UNCTAD's searchable database online.
Jones's University Mapping Project would not only provide students with a strong foundation in international and economic law but also a professional network that spans continents. The UNCTAD took Jones up on his offer and appointed him lead consultant on the project.
As a 2L entering his third year of law school, Jones reached out to Michigan Law. In full support of Jones and the University Mapping Project, the Law School offered him the opportunity to move forward with his plans as an independent research project to be completed for credit. "My work during the 2012–13 academic year was only possible because the Law School recognized the value of the project," said Jones.
With the guidance of Steven Ratner, the Bruno Simma Collegiate Professor of Law, Jones began implementing his designs. "Professor Ratner was a great support to me as a thought partner on how to implement the project," said Jones. "He helped me set goals and held me accountable to make sure everything was moving forward as needed."
As a 3L, Jones recruited eight universities and 62 students from different countries to join the project. He trained professors and supported them in the training of their students, reviewed all student work for accuracy, compiled their research, and submitted it directly to the United Nations for publication. Together, they mapped 238 agreements, more than doubling the number of BITs mapped by UNCTAD.
Three years later and four years into the project, Jones has worked with 48 professors, 42 universities, 22 countries, and 550 students to map nearly every BlT in existence with publicly available text, with the exception of those written in niche languages such as Slovak or Slovenian. "To be involved in such a large-scale project and have so much autonomy over the creation and execution of the project has been really fun," said Jones.
Jones credits his work on the mapping project with helping him find his niche in the academic community and partially for his acceptance to the University of Chicago, where he is currently pursuing a PhD in economics. He hopes to continue his work with the mapping project by following his interest in creating similar databases at the intersection of law and economics. "I think there is an opportunity to use this network of professors I have created to try and work on similar projects in the future," said Jones.
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