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Become Owner No. 1501Promoted as Porsche's next generation flagship super sports car, the Carrera GT was officially unleashed onto the international motoring market in 2003, with Porsche planning to build just 1,500 models over the next three years at its factory in Leipzig, Germany.
Packed with racing-spec technology, the Carrera GT features an ultra-lightweight and durable carbon fiber monocoque frame. Combined with the all-new 5.7 liter V10 cylinder engine, the Carrera is capable of a staggering top speed of over 330km/h, with acceleration from 0-100km/h in less than 3.9 seconds. The Carrera GT marks a departure from Porsche's traditional horizontally placed boxer engine, laying the foundations for an exciting new era in the amazing history of one of the world's top sports car makers.
Stylish Black and Silver Interior1/12 scale semi-assembled display model of Porschefs flagship super sports car, the Carrera GT. This premium replica is made from a variety of high quality parts, including ABS resin cowling, metallic mesh grille, synthetic rubber tires and die-cast metal parts. Assembly of the delicately curved body follows that of the full-size car, with a beautiful Speed Yellow paint job adding the perfect finishing touch. Durable die-cast suspension arms combine with working dampers and stabilizers for real-action suspension. Metal hinged doors, hood and rear cowl open realistically to display fully detailed interior and V10 engine. Rear wing pops-up to extended position when license plate is pressed, while hard-top can be removed and stored under hood for convertible style. Owning this model is the next best thing to owning an actual Carrera GT! Includes illustrated pamphlet detailing car's background and specifications (Japanese with English translation). Overall length: 385mm, Overall width: 160mm, Overall height: 97mm


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Our classic workshirt cut in a French Navy cotton twill. Brushed for a soft finish, yet heavy duty enough to allow one to axe-fell a tree, or swan around a private function. Features double top stitched patch pockets and branded lazercut horn buttons. Style it layered or wearing as a single jacket.
We recommend dry clean only.
Model is 6'1" and wears a size M
This item is part of a limited edition run manufactured in China. The fabric is 97% Cotton, 3% Elastane with four hole horn buttons.
FREE RETURNS - We now offer free returns (UK only, but don't worry world it's coming soon!)
FULL REFUND - We now offer a full refund unless item description is marked with 'End of Line'. End of Line items can be exchanged or offered a Credit Note. Return within 14 days in original condition (click here for full T's & C's)
FREE SHIPPING - Free shipping for orders over £125 (UK only). Otherwise Standard delivery is £6.5. Prices outside UK vary, see here.
By purchasing you are bound to our full T's & C's.

subset: commoncrawl


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"Batman Arkham City:" Can Anyone Make a Good Superhero Game? [OPEN THREAD]
Poor superheroes: They do so much to save the planet time and time again and we can't even make a decent video game about it. Superhero video games are commonly a wasteland of awful, which isn't entirely their fault.
They're usually attached to a film and are given shorter development times. The tie-in with major movies also means that the games don't have to be great in order sell.
There are, of course, wonderful exceptions to the rule. Some superhero games like the 1992 X-Men Arcade game or 2009's Batman: Arkham Asylum turned out experiences that tapped a franchise and delivered an enjoyable game. However, for every success, there are raspberries like Superman for the Nintendo 64 or the recent Iron Man video games.
This fall there are a trio of big-name games hitting consoles, including Batman: Arkham City, a sequel to the Dark Knight's first successful high-def romp.
Previewing Batman: Arkham City and playing around with two other superhero games — X-Men: Destiny and Spider-Man: Edge of Time — gave us a little bit of hope. X-Men: Destiny had us running around as one of three new mutants who beat up thugs. It's nice to fight with iconic characters like Gambit or Cyclops but too much of it felt like a series of tasks — talk to a person, fight some bad guys, talk to a person, fight some bad guys — rather than a story. The game looks pretty good and the fighting, albeit simple, serves its purpose.
Spider-Man: Edge of Time pits you as two, parallel universe Spider-Men, the modern day Spidey and one from the future. The game plays great but runs into the same problems most other Spider-Man games face: How do you approximate the spatial awareness, agility, speed and reflexes of Spider-Man into a controller? Well, you do the best you can. Web swinging and sending out zip lines are fun and a special button lets real-world Spidey enter a Matrix-like slow-mo highlight his speed. Of course, the camera gets lost during these acrobatics and it can be disorienting to automatically zip to something you can't see on-screen.
One of the reasons the new Batman video game series has done so well is because Batman is based in (relative) reality. Batman can't fly or cling to walls but instead gameplay is based on sneaking around, using gadgets and setting ambushes. Combat still feels a bit like a min-game (you time button presses to avoid attacks and there are few innate combos) but the game really lets you feel like a modern-day Bats. The game now encompasses all of Arkham City with a more open-world, Grand Theft Auto-style atmosphere.
It might be marginally easier to make a Batman game, but the development team at Rocksteady has clearly put in some time to make sure the game isn't just another one of those awful superhero games you hear so much about. Which leads us to ask:
Let us know in the comments why you think superhero games are so often a disaster and tell us your own favorite games that finally got it right.


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Jump to navigation
TopBetta, ClassicBet and MadBookie have recently merged to form a brand new online betting site 'PlayUp Sportsbook'. Backed by international gambling conglomerate 'PlayUp', the new player in the Australian market is set to instantly become a hit! For more details, check out our PlayUp Review here.
TopBetta is an Australian sports betting site which launched in 2010 and is not only known for offering an array of the usual betting markets such as racing, AFL, NRL and Cricket, but also offering sports and racing betting 'tournaments'. Like any of the best Aussie wagering sites, TopBetta's bread and butter is offering great prices on a range of different markets, however, TopBetta is also great new site for punters looking for something a little different, so we suggest everyone give TopBetta Tournaments a try. Read our full TopBetta review for more details regarding what TopBetta has to offer!
When you first arrive at TopBetta.com.au you will be prompted with a login screen which allows you to easily navigate to the three main sections of the site – Racing, Sports and Tournaments. If you're not interested in tournaments, TopBetta works as a perfect stand alone wagering site, and from the racing and sports tabs you can easily access all the great markets and odds they have on offer.
While their main project as a new company was to inroduce tournament betting to Australia, TopBetta have drastically improved their standard betting markets in recent times, putting them on par with the biggest bookmakers in Australia. They have also displayed innovation with the announcement of their "GOAT SP" product which provides the "Greatest Of All Totes" to give punters the best bang for their buck. Put simply, GOAT SP combines the Official Starting Price (or TopBetta fixed SP, should an official SP be unavailable) and the final best tote dividend, and pays customers at whichever is greater.
As we mentioned above, TopBetta have been working hard to improve the amount of markets on offer to punters. In an aim to get their tournament feature up and running, it was thin pickings for some of their sports markets, particularly the American sports. However, that has now changed and TopBetta now offer hundreds of markets on NBA, NFL, and Ice Hockey as well as the more popular Australian and international sports. Navigating the sports side is just as easy, with a drop down 'A/Z Sports' tab at the top or your page where you can select from an array of sports.
The one aspect that TopBetta offer that no other bookmaker in Australia does is the phenomenon of tournament betting. The concept is quite simple and anyone who is familiar with how poker tournaments work will be right at home.
TopBetta also offer a regularly updated blog for punters to peruse, reporting on news from the betting world, providing tips and displaying opinion pieces.
One question Australian punters ask is 'How do Tournaments at TopBetta work?"
Basically, there is a tournament that as an example may be Round 3 of the AFL season. There is then an entry fee that punters pay – say $20 – which goes into a prize pool. Each punter is then given a fantasy bankroll to bet on any games they wish for Round 3 of the AFL. The punter who makes the most fantasy profit from their start bank wins the tournament and is awarded the money from the prize pool or at least the largest portion of it depending on how many people enter the tournament.
There are tournaments on offer for all kinds of events such as Cricket, the A League, NRL and AFL and there are regular racing tournaments running every day that pit punters against each other for certain race meets.
In recent times, TopBetta have offered some huge prizepools for their tournaments. There are weekly $5,000 tournaments for both NRL and AFL for just a $10 buy-in. They have also held multiple $250,000 prizepools for major horse racing carnivals with a $100,00 guaranteed top prize. Rumours are that a $1 million prize pool tournament will be held later in the year.
Even better is that TopBetta offer heaps of 'freeroll' tournaments which cost nothing to enter and feature prize pools donated by TopBetta, so it's a great way to test out the TopBetta software and give sports betting tournaments a try at TopBetta!
TopBetta – Positives
* Super-fast cashouts
* Great range of racing and sports markets
* GOAT SP offering great odds for racing punters
* Unique sports betting 'tournaments'
* Free-to-enter tournaments with real-money prize pools
* Huge prize pools of up to $1 million on offer
* Great alternative to the big-name sites
* Easy to use live chat feature
TopBetta – Negatives
* Sports betting markets still slightly limited, although improving
* Although solid promotions, sometimes don't offer as many as the bigger agensies
Information in above video correct at time of recording.
Always remember to Gamble Responsibly.
Editor's note: Take care when signing up to new sports betting agencies. Be sure to read all terms and conditions of any bonus offers, deposit/withdrawal requirements and identification verification on each respective site, as some of the information on this page may be outdated. Before You Bet will do their best to keep this page up to date, but takes no responsibility for any information on this page being incorrect.
|Unibet Australia
|Betfair Australia
|DraftKings Australia


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Wine Notes
The 2017 Cabernet Franc was produced with fruit from the Sommerville vineyard on Malpas Road., just outside of Willunga. 1.2t were harvested on March 24. 2017 was a vintage that was moderately cool by McLaren Vale standards, and saw grapes ripen with excellent phenological ripeness in congruence with sugar ripeness, leading to good flavour at lower alcohols in the finished wines. Ferments were kept cool and therefore fermented slow, and after primary fermentation the wine was gently basket pressed into old oak and matured on fine lees for 12 months prior to bottling.
The wine was bottled unfined and unfiltered.


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Recent articles by Josh Crabb
- Surge of COVID-19 cases hammering Manitoba's healthcare system
- Two men plead guilty in home invasion and murder of Winnipeg teen Jaime Adao
- Site of Manitoba's deadliest COVID-19 outbreak still dealing with staffing shortage
- 'Concerned, worried, scared': Death toll rises in Parkview Place care home outbreak
- Client's COVID-19 diagnosis being kept from home care workers, union says
- Former lawyers file human rights complaints over barriers in Manitoba court buildings
- Consultant sought to evaluate Manitoba's provincial parks
- Manitoba doctor's assumption about Cree elder's alcohol use was racist, daughter says
- Sheegl's lawyer seeks court order to question RCMP in lawsuit over WPS HQ project
- 'What happened to him?': Stepdaughter makes plea for information in Bud Paul homicide investigation
Josh CrabbContact
Prior to working at CTV, Josh spent two years at CKX Television in Brandon, Manitoba and worked for three years at Shaw TV in Red Deer, Alberta.
Josh moved back to Manitoba in 2010. He joined the CTV News Winnipeg team as the station's Brandon-based video journalist, covering stories from the Wheat City. Two years later, he made the move to the CTV Sports department as a sports reporter and anchor. He then transitioned into the role of general assignment reporter and video journalist. Josh reports on a wide range of stories including, but not limited to: flood, crime and court, and rural Manitoba stories.
Josh graduated from Assiniboine Community College's Media Production program in 2005. He speaks English.
Meeting new people every day and having the privilege of sharing their stories with others is why Josh enjoys being a journalist.


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Difference between revisions of "Oceania"
m (added oceaniashard.com)
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==External Links==
==External Links==
* [http://town.uo.com/guilds/shard_19.html Official guild list]
* [http://town.uo.com/guilds/shard_19.html Official guild list]
Revision as of 19:17, 27 May 2012
|Oceania Shard
|January 28, 2000
|Time Zone:
| Australian EST
|Maintenance Time:
|IP Address:
| 18.104.22.168
Oceania server provides for the South West Pacific. It resides in Australia.
A quiet shard, Oceania has plenty of wide open spaces for new housing, and any player with the gold can find a spare 18x18 plot within just a few minutes of searching. Likewise, Felucca is barely more risky than Trammel to the novice wanderer in that nearly all PvP combat centers on the Britain moongate or the Champion Spawns.
Despite this, the New Haven bank is often visited by more experienced players looking to help the new. Finding a guild to join or fellow adventurers to journey with is seldom a lengthy chore. Oceania has no noticeable server lag and so some non-locals find it just as smooth to play on as their home shards.
The ever popular Luna bank has some interesting quirks in that items are either missing or duplicated. Players attempting to go through doors might find that there are actually two of the things blocking their path, while the chests in the central area float in the air.
See Also
- Oceania Items - Items unique to the shard
- Oceania Legacy - The rise and fall of Oceania Legacy


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Questions About Credit/Quote Amount
Think of credits like little gifts. We offer credits as a reward to faithful users like yourself. We are working on putting together awards, swag and more for the special people that help us grow. After all, we can't do it all ourselves. Our users are essential to our success and we want to show them how much we appreciate them. After we finalize the various award levels we will be releasing an official list of rewards per credit levels. Stay tuned!
Each credit can be exchanged for one price quote from four local service providers. The more credits you have, the more free quotes you can receive. How great is that?
Ideally, we'd like to give you everything for free. We'd like to get everything for free as well. Who wouldn't? The thing is, we work with real people whose time and energy we value greatly. Each quote we request from a service provider costs us money. Instead of passing that whole cost onto our users, we absorb some of it by providing three free quotes per month. We found, through our pilot tests, that serious users were happy with three free quotes.


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A San Francisco Superior Court has approved California Insurance Commissioner's rehabilitation plan for Majestic Insurance Co., a failed workers' compensation insurance carrier.
Under the plan, Majestic's insurance liabilities and certain assets will be transferred to AmTrust North America Inc., which will assume responsibility for the administration and payment of all policyholder claims under Majestic's policies. The plan also includes a loss portfolio transfer reinsurance agreement, sales of renewal rights, and an asset purchase transaction.
New York State's Workers' Compensation Board, as well as former members of the self-insured workers' compensation program Contractors Access Program of California, which was managed by now defunct Majestic Insurance Co., had voiced objections to the rehabilitation plan.
The former CAP members believed Majestic's actions caused CAP to fail, and that the state Department of Industrial Relations and Department of Insurance failed to take appropriate actions as required by law.
The New York Workers' Compensation Board objected to the rehabilitation plan and attempted to portray Majestic's conservation as a conspiracy between California Insurance Commissioner Dave Jones, as the statutory conservatory of Majestic, to deprive NYWCB of its rights, according to Commissioner Jones. "In reality, NYWCB's policyholder rights are 100 percent protected by the rehabilitation plan, and its objects are a transparent attempt to leverage a favorable settlement of its civil litigation in the Supreme Court of New York against Majestic's bankrupt parent by threatening to derail the rehabilitation plan," he said.
NYWCB has asserted policyholder claims as the successor to certain self-insurance trusts in New York that were policyholders under a number of aggregate excess loss policies issued by Majestic. NYWCB also has asserted damage claims based on its New York litigation that amounts that NYWCB estimated exceeds $475 million.
However, the California Court accepted California Commissioner Jones' rehabilitation plan for Majestic, essentially overturning all objections.
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Henry T. P. Cansler World War I Diary Vertical File Manuscript | Southern Illinois University Special Collections Research Center
One pocket diary, 3 inches by 5 inches, containing a 49 pp., semi-literate, postwar account by Sergeant Henry T. P. Cansler of his service in Company C, 114th Machine Gun Battalion, 59th Infantry Brigade, 30th Division (nicknamed the Old Hickory Division) in World War I. Covers the period from May 1, 1918, when he left training at Camp Sevier in South Carolina, to October 12, 1918, including the voyage to France, training in France, action near Ypres, and the Somme offensive, including the battle of Bellicourt. Features graphic descriptions of bodies dismembered by artillery fire and his encounters with wounded and dying comrades and German prisoners. Contains a list of the men in his unit.
Collection also includes a small account book, 3 by 5 inches, listing the names of men in his squad and their possessions; a brown cloth bag or wallet marked with the name of Arch M. Nelson, Sweetwater, Tennessee, a member of Cansler's unit; Nelson's metal Social Security card, in a leather holder; and a 1914 Webster pocket dictionary.


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CapitalCityTickets.com carries a vast selection of Arroyo Seco Weekend concert tickets at affordable prices. The Arroyo Seco Weekend will take place at Brookside Golf Course in Pasadena, CA on June 24-25.
Tom Petty & The Heartbreakers, Mumford & Sons will headline the event. The event is named after The Arroyo Seco stream, "meaning "dry stream" in Spanish.
Saturday, June 24
Tom Petty & The Heartbreakers, Alabama Shakes, The Meters, Dawes, Live, Broken Social Scene, Charles Bradley & His Extraordinaires, Preservation Hall Jazz Band, Jeff Goldblum And The Mildred Snitzer Orchestra, Roy Ayers, William Bell, John Mayall, and The Bennie Maupin Ensemble.
Sunday, June 25
Mumford & Sons, Weezer, The Shins, Fitz & The Tantrums, Andrew Bird, Lukas Nelson & Promise Of The Real, Galactic, The Revivalists, Andy Grammer, ZZ Ward, Lettuce, Alice Smith, The Mowgli's, David Lindley, Con Brio, and NK Band. Attendees will also be treated to a performance from Jamtown feat. Donavon Frankenreiter, G. Love and Cisco Adler.
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I recently began my mini Italian adventure in Rome. I had never been to Rome before, and to be honest it was nothing like I had expected: neither for better or worse, it simply was just not how I had imagined. I found it hard to distinguish between different boroughs; this was due to the whole of Rome being drenched in culture and the beautifully developed, Greek inspired, architecture that is found everywhere, no matter what area you're in. Every building is picturesque. Every public building looks like a grand museum or embassy, and standard apartment blocks are rustic terrace houses that have stood the test of time, yet by no means look like they have been restored or refurbished in any way. It was almost like stepping back in time. This beautifully kept ancient city feels as if it hasn't been touched by the ugly that (sometimes) comes with modernity…
However, Rome is unfortunately spoilt by tourism. The ancient city is over-run by 'selfie stick' users, 'selfie stick' seller's and general cliché tourists and pestering 'looky looky' men… Of course, this is wholly inevitable due to it being the capital city and thriving with history and culture. Sadly though, what really bugged me was the food. Being a foodie; someone who plans their day around food during normal day to day routine (let alone what I'm like on holiday!!), I was so excited to over indulge on carbs and ice cream. This was going to be overly excessive eating to the maximum. We had planned the restaurants we wanted to visit way in advance of our trip. I had deprived myself of Italian food prior to the trip all ready for a giant binge on carbonara and pizza. Straight off the plane, without a reservation we hit up Pizzeria "La Pratolina" and they managed to squeeze us in, as they were fully booked on a Monday! Being terrible at languages and not knowing a large selection of the meat toppings, we decided to share a Margherita (as it's always a strong indication of a good pizza) and shared the recommended flat bread by our lovely waitress. As for the wine, at €9 a bottle I didn't expect much… however despite its price, it was one of the most enjoyable red's I have ever had. The staff, food, wine was all perfect and started the trip off on a really positive food note…
Sadly our foodie experience in Rome did go down hill… We planned to try Rome's best Carbonara at the trattoria (traditional Roman cuisine) "Da Danilo" and "Vino e camino" for some specialty artichoke… Much to our disappointment the majority of the restaurants favoured by locals were closed due to them being family run businesses and they had left for big family holidays. So with a bit of help from trip advisor and an eye for food we tried our luck at stumbling across gems, and despite having an incredible fillet steak and some varying Carbonara's we sadly also experienced some frozen pizza and some extremely over priced establishments trying to make a quick buck of off ignorant tourists… Rome is full of touristy traps or 'trattoria's' that are probably equal to a lot of Italian chains found in the UK... which was disappointing to say the least, and none of these restaurants were really worth note. However it would be unfair to say I didn't eat good food; I was just underwhelmed on occasion and disappointed that the restaurants we had previous researched had been closed. However, saying this just makes me want to return to the beautiful city to try some of these well-reviewed restaurants. On a side note, the room that we stayed in, in a converted apartment was fantastic, and I cannot recommend it more… An old apartment block hosting a traditional rustic communal stair case and a lift that looked like it should have been in the Grand Budapest. Also hosted our lovely modern apartment: "St. Peter's Key's" whilst still retaining its traditional character, and based right next to the Valtican City, this modern renovated apartment is basically, perfect. I should also add, the best ice cream I ate in Rome conveniently came from a lovely Gelataria pretty much next door… I guiltily admit we actually went there more or less twice a day, so although I'd like to say I'm not a creature of habit, I was too scared to be disappointed and try other gelatarias. At "Caffè Portofino" a boy who was just like 'O' almost always served us (I do apologise for all the Grand Budapest Hotel references, it is a firm favourite of mine at the moment… Should have probably travelled Budapest) None the less, O served the best ice cream: Crema, Kinder, Bicolleta, Banana, and Cheesecake, just a few to take note of and most definitely try.
Along with trying the brilliant pizzeria I have mentioned, I would absolutely recommend checking out Rome's equivalent to Shoreditch; the hip neighbourhood of Monti. I would suggest visiting all of the tourist attractions (despite the long & daunting cues) and most definitely checking out the Maxxi Museum which was urban contemporary heaven (Eames chairs galore) that was a complete and drastic contrast from all of the traditional architecture which otherwise seems inescapable.
I hope you all enjoy the photos I took throughout my trip in Rome. It was really hard to pick my favourite shots but these are a select few that I wanted to share.
Rome is a lovely place to visit and I would recommend it to anyone looking for a full-on busy city break. Do feel free to ask me any questions regarding my trip, I will help in anyway I can!
Photo's by Jude J Taylor


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It's a perfect escape from the memories of her cancer treatments.
Today, Emily has no worries. All she has to do is shop. It's a perfect escape from the memories of her cancer treatments.
She's at her favorite mall – but it's the first time she's ever arrived in a limousine. Her first stop of the day made a splash at the cosmetics store; she has visions of one day being a cosmetologist and hair stylist. The staff treats Emily to a makeover and loaded her up with their best products. They even give her one of their own "employees-only" items … a tool belt filled with makeup brushes. It's a perfect gift that makes her feel like she's already a cosmetologist.
Then, Emily is on her way to pick out electronics. Her shopping list includes a notebook computer and a camera. After that, maybe some sweet-smelling soaps and fragrances.
Hours later, Emily's shopping spree is over. She fills her limousine full of shopping bags and heads home. Still, the memories of her day, the care of her wish-granting volunteers and the warm welcome of every store employee will always be just a thought away.
This story makes me feel
June 25, 2012 - 11:25 AM
I hope you the best. I hope you on had fun going shopping. lolz. xD ~_~
May 08, 2014 - 11:29 AM
Hi Emily! I am also a cancer patient and I'm so glad you got to have your shopping spree! :) I wish you the best! Keep on smiling!
April 16, 2015 - 8:55 AM
liver transplant
I wish to go on a birthday shopping spree
liver condition
I wish to have a Teacup Yorkie puppy
I wish to have a princess ball
Stay in Touch!
Sign up to receive email from Make-A-Wish.


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Recently I took all four of my young sons to a swimming pool by myself. My two older boys, who are like fish in the water, immediately jumped in and were having a blast. For a brief moment I took my eyes off our three year old who had wandered to the other side of the pool to join in the fun with his brothers. I turned around just in time to watch him jump in and sink beneath the surface. In what seemed like both an instant and slow motion eternity, I called out to his brothers who were nearby to help him while I frantically handed my seventeen month old to a stranger and ran over to the other side of the pool. As it turns out, neither of my two sons could touch bottom there and so, holding their breath, they each lifted him out of the water for the briefest of moments only to have him sink again before I was able to reach him. To say the least, this was one of those horrifying and humbling moments of parenthood when you are reminded that life is so fragile.
As I've often written before in my articles, the love that I have for my children has taught me volumes about God's love for us, His children. I was in no way mad at my son for jumping in. Rather, I was scared and heartbroken at the possibility that he could have died. How must it affect our Heavenly Father when He watches us sink into the sea of our sinfulness and choose spiritual death?
One of God's greatest gifts to us is freedom. The Catechism of the Catholic Church states that "sin is an abuse of the freedom that God gives to created persons so that they are capable of loving him and loving one another." (CCC 387) I cannot force my children to love me. All I can do is model love for them and hope that they will love me in return. Neither does God force us. Like any good father, however, He does provide us with certain guidelines, not for the sake of demanding compliance, but for the sake of our happiness.
One of the tried-and-true sources from which we find God's guidelines are in the Sacred Scriptures. Sunday's Scripture reading taken from Psalm 128 states: "Blessed are you who fear the LORD, who walk in his ways…Your wife shall be like a fruitful vine…your children like olive plants around your table." All throughout the scriptures, children are seen as a blessing. In this Sunday's Gospel, Jesus himself says, "Let the children come to me; do not prevent them, for the kingdom of God belongs to such as these."
The Church teaches that "children are the supreme gift of marriage and contribute greatly to the good of the parents themselves." (CCC 1652) I couldn't agree more. While raising four boys can be extremely exhausting and challenging at times, I can't imagine life without any of them. I've heard parents, especially mothers, say that their children are like an extension of their heart walking around outside of them.
Sometimes when I bring all four boys along with me, I still find myself distraught at the negative reactions from people. Just the other day, a friend of mine was talking with a stranger who had two children of his own. When my friend pointed out that I had four boys, the guy responded with a shake of his head, "No thanks!"
This negative reaction is not uncommon and has its roots in the contraceptive mentality so pervasive in our society. The Catholic Church's teaching against artificial contraception is another one of those guidelines set before us for the sake of our happiness. But people, yes, even Catholics, do indeed freely choose to go against the Church's teaching on "openness to life." From the earliest of times, God has given guidelines to His people only to have them use their God-given freedom to reject these guidelines. In the end, sin never makes any of us happy. The divorce rate for couples who use artificial contraception still hovers at a stunning fifty percent. Even when couples are considering getting off of contraception, this can seem utterly terrifying and so they need an extra amount of God's grace.
While the Church offers a guideline which people are free to reject, I find it ironic that a government which upholds freedom of choice as one of its basic tenets is doing just the opposite. The government-sponsored HHS "mandate," rather than respecting religious freedom, is coercing church institutions to go against their conscience by forcing them to pay for preventive health care services, eg. artificial contraception among others. This "Trojan Horse" is one which, if we take our eyes off of religious liberty even for the briefest of moments, may cause us to sink into a pool from which we may need rescue.
Keith Jiron is Coordinator of RCIA and Adult Education at St. Michael the Archangel Parish in Leawood.
Daily Scripture Readings
For complete daily Scripture texts, click here. http://www.usccb.org
Monday, October 8
Galatians 1:6-12
Psalms 111:1b-2, 7-8, 9 & 10c
Luke 10:25-37
Tuesday, October 9
Galatians 1:13-24
Psalms 139:1b-3, 13-14ab, 14c-15
Luke 10:38-42
Wednesday, October 10
Galatians 2:1-2, 7-14
Psalms 117:1bc, 2
Luke 11:1-4
Thursday, October 11
Galatians 3:1-5
Luke 1:69-70, 71-72, 73-75
Luke 11:5-13
Friday, October 12
Galatians 3:7-14
Psalms 111:1b-2, 3-4, 5-6
Luke 11:15-26
Saturday, October 13
Galatians 3:22-29
Psalms 105:2-3, 4-5, 6-7
Luke 11:27-28
Twenty-eighth Sunday in Ordinary Time,
Sunday, October 14
Wisdom 7:7-11
Psalms 90:12-13, 14-15, 16-17
Hebrews 4:12-13
Mark 10:17-30
Monday, October 15
Galatians 4:22-24, 26-27, 31-5:1
Psalms 113:1b-2, 3-4, 5a & 6-7
Luke 11:29-32
Tuesday, October 16
Galatians 5:1-6
Psalms 119:41, 43, 44, 45, 47, 48
Luke 11:37-41
Wednesday, October 17
Galatians 5:18-25
Psalms 1:1-2, 3, 4 & 6
Luke 11:42-46
Thursday, October 18
2 Timothy 4:10-17b
Psalms 145:10-11, 12-13, 17-18
Luke 10:1-9
Friday October 19
Ephesians 1:11-14
Psalms 33:1-2, 4-5, 12-13
Luke 12:1-7
Saturday, October 20
Ephesians 1:15-23
Psalms 8:2-3ab, 4-5, 6-7
Luke 12:8-12
Twenty-ninth Sunday in Ordinary Time, October 21
Isaiah 53:10-11
Psalms 33:4-5, 18-19, 20, 22
Hebrews 4:14-16
Mark 10:35-45
The full text of the Scripture readings for this week and next week can be found here: http://www.usccb.org/
Click on the "Daily Readings" tab on the right hand side of the page.


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SEC Proposes New Pay Ratios Rules
By David Lavan and Mary Newman, Dinsmore & ShohlThe Securities and Exchange Commission (the "Commission"), by a 3-2 vote, proposed rules to require companies to disclose the median annual total compensation of all employees and the ratio of that median to the annual total compensation of the company's chief executive officer. These proposals are designed to implement Section 953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act ("Dodd-Frank'). As proposed, the new rules provide flexibility in calculating median annual compensation for employees to reduce costs.
The proposed rules from the Commission would require yearly disclosure in annual reports, proxy statements and registration statements, of a company's "pay ratio." The SEC did not propose any date of effectiveness for the rule, however the compliance period would begin in the first fiscal year beginning after the effective date of the rule, and disclosures would be required in the annual reports or proxy statements filed with respect to that fiscal year. In our view, for a calendar year-end company, the earliest pay ratio disclosure will be required will be in proxy materials or information statements relating to its 2016 annual shareholders meeting and will relate to compensation paid in the 2015 fiscal year.
Employees covered
In determining the median annual total compensation of its employees, a company will be required to consider all full-time, part-time, seasonal and temporary workers employed as of the last day of the relevant fiscal year by the company and any of its subsidiaries, whether located within, or outside of, the United States. The median compensation measurement does not include independent contractors, "leased" workers or other temporary workers employed by a third party. Companies will be permitted to annualize the compensation of permanent employees that did not work for the entire fiscal year (such as a new hire), but will not be permitted to annualize the compensation of seasonal or other temporary employees.
Flexibility in method
To reduce the cost of compliance with the proposed rule, the Commission provided companies with the flexibility to choose an appropriate methodology for identifying median annual total employee compensation. For this purpose, companies that elect not to use their entire employee population may rely on statistical sampling and reasonable estimates, and can use any consistently applied compensation measure (e.g., W-2 wages or cash compensation) to identify the median employee. Once identified, though, the median employee's annual compensation must be calculated according to Item 402(c)(2)(x), though reasonable estimates may be used in determining the annual total compensation. The determination of the annual total compensation of the company's chief executive officer, will continue to be determined in accordance with Item 402(c)(2)(x) of Regulation S-K.
Companies must consistently apply and disclose the methodology, assumptions, adjustments and estimates used in calculating their pay ratio, and must clearly identify any estimated amounts.
Covered Issuers
The pay ratio disclosure requirements will apply to companies that are otherwise required to provide a summary compensation table under Item 402(c) of Reg. S-K.
Smaller reporting companies, foreign private issuers, MJDS (Canadian) filers that file on Form 40-F and emerging growth companies under the JOBS Act are not subject to the pay ratio disclosure requirements.
The proposal would provide a transition period for newly public companies. For these companies, initial compliance would be required with respect to compensation for the first fiscal year commencing on or after the date the company becomes subject to the reporting requirements of the Securities and Exchange Act of 1934 (the "Exchange Act").
Location of Disclosure
As proposed, the pay ratio disclosure will be required in any annual report, proxy statement or registration statement that requires executive compensation disclosure under Item 402 of Reg. S-K. The pay ratio disclosure must be updated annually through a company's annual report or proxy statement, not later than 120 days after the end of the fiscal year.
The pay ratio disclosure will be considered "filed" not furnished, and is therefore subject to potential liability under the Securities Act of 1933, when included in registration statements and the Exchange Act, when included in annual reports or proxy statements.
The Commission's release proposing the new pay ratio disclosure requirement is available here. (http://www.dinsmore.com/files/Uploads/Documents/33-9452.pdf)
If You Have Any Questions About the Pay Ratio Rules
The rules proposed by the Commission will require disclosure in registration statements, proxy materials and annual reports to shareholders for many issuers. If you have any questions regarding the proposed pay ratio rules, please contact the authors of this article.
About the Authors
David Lavan is a partner in Dinsmore's Corporate Department who focuses his practice on all aspects of SEC registration, reporting and compliance. He routinely advises clients on public and private offerings of debt and equity, disclosure matters, corporate governance and accounting issues. Lavan previously served as Special Counsel in the Division of Corporation Finance in the SEC.
Mary Newman is a member of Dinsmore's Corporate Department and represents both public and private clients in a wide variety of securities matters and mergers and acquisitions. Prior to her practice, Newman worked as a writer and editor for a publisher of books and websites on personal finance topics, and co-authored "An Investor's Guide to Trading Options."


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Our Services
Thailand Elite originates from a singular goal to present the finest that the country has to offer into one unique package for our honoured guests.
The Cabinet passed a resolution approving the Thailand Privilege Card Project as proposed by the Ministry of Tourism and Sports, whereby the Tourism Authority of Thailand was to implement the project in the form of limited company.
Its objectives are to generate revenues from foreign visitors; and draw high-end visitors, businessmen, investors and the long stay groups, by offering rights and services to members. Such services are from both public and private sectors, like Visa Privilege, Special Entry Visa, and Privilege Entry Visa.
As part of the Tourism Authority of Thailand, this exclusive club has access to privileges that money alone cannot buy. Thailand Elite is the world's first country membership programme with benefit for immigration, leisure, business, and much more.
Preferred treatment at golf courses, spas, hotels, clubs, and medical facilities throughout Thailand await our Members. As a friend of the country, we want you to enjoy your time here to the fullest extent. We look forward to presenting you with our Thai heritage and hospitality famous the world.


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Amendment would help Salem power plant
Would thwart legal challenge by CLF
A Salem state representative who has faced prior criticism for insisting on language beneficial to a planned power plant in his city is facing criticism anew for seeking to smooth the path for the plant in a bill adding new regulations to stamp out gas leaks.
Rep. John Keenan, a Democrat and co-chair of the Committee on Telecommunications, Utilities and Energy, said the language he added with the support of committee colleagues would let stand approvals from the Energy Facilities Siting Board and other oversight bodies for construction of a natural gas plant at the site of Salem's closing coal power plant. The step is necessary, he said, in the face of litigation filed by the Conservation Law Foundation, which he said is seeking "another bite at the apple."
The provisions added to the bill (H 2950) would exempt from certain permitting requirements Footprint Power's plans for a new plant at the site of the Salem Harbor Power Station.
Rep. Lori Ehrlich, a Marblehead Democrat, filed similar legislation (H 2933) to address gas leaks, which unlike Keenan's bill did not have the backing of gas companies, and said she would vote against her colleague's bill if the provisions for Footprint are not deleted.
Ehrlich, who has fought to reduce gas leaks since she entered the Legislature five years ago, called the Keenan additions a "blatant special favor" for Footprint Power.
"It really makes me wonder what the developers are so worried about in the permitting process that they can't see it through. To circumvent normal reviews to me is a signal that something is terribly wrong with the proposal or it would stand on its own," she told the News Service.
Before becoming a legislator, Ehrlich worked on requiring the coal plant to clean up coal waste from a local aquifer, and she has pushed for a bill (H 2933) that includes a more aggressive schedule for utilities to repair leaking natural gas pipes, which she said can lead to violent and costly explosions or the slow death of nearby vegetation.
Ehrlich does not support the conversion of the Salem power plant from coal to natural gas, describing how after years of air pollution and high rates of cancer and asthma in her community she is "not excited to have another one."
"They like to claim they're improving emissions because a gas plant runs cleaner than a coal plant, but in reality they're taking credit for a plant that's already closing," Ehrlich said, a reference to the scheduled June 1, 2014 closing date for the Salem Harbor power plant.
The Salem Democrat faced criticism from his North Shore colleague Ehrlich last year for what environmental opponents described as a "sweetheart deal" providing Footprint and other developers seeking to convert coal-fired plants to natural gas with long-term, 15-year energy contracts. Added to a larger energy bill, Keenan's proposal drew opposition from the Patrick administration and the attorney general and was ultimately replaced with a compromise giving Footprint extended property tax incentives through 2019.
"That was not a sweetheart deal last year. This is not a sweetheart deal this year," said Keenan. He said, "They've done everything by the book."
Footprint is seeking to build at the site of a soon-to-be-shuttered coal plant along the water, and Keenan said the region needs the added energy to avoid "rolling brownouts."
"This project has to go forward for the reliability of the grid," Keenan said.
The bill states the developer is "hereby granted a composite of all state and local permits, approvals and authorizations." Keenan said CLF has taken every opportunity to appeal permitting decisions by regulatory boards involved in the process. He believes the new plant must go online by June 2016.
"They need to tear down and build a new power plant in 30 months. I don't want to push it off for a year," he said.
In a blog post, CLF Attorney Shanna Cleveland said Keenan's attempt to secure the power plant "no matter the cost, is both unconstitutional and unconscionable," and said alternatives to strengthen the grid with "already planned transmission upgrades, may be cheaper and less carbon intensive."
Cleveland also questioned whether the new gas-fired plant would meet the state greenhouse gas reduction goals mandated under the Global Warming Solutions Act.
"The bottom line is that while natural gas may burn cleaner than coal and oil, it is still a fossil fuel with significant carbon emissions. Locking in new natural gas infrastructure means locking out zero-carbon technologies like wind and solar," Cleveland wrote.
In addition to establishing a gas leak classification system, Keenan said his bill includes a provision for inspecting vaults, which can lead to death for utility workers in the case of a gas leak, and allows the utilities to seek rate increases for work before the job of replacing and repairing leaky pipes has been completed.
"Cape Wind is not going in the ground yet, so there are a lot of problems, and over 3,000 megawatts or so that are going to be coming offline in the next three years," Keenan said. "I think there is a real potential and concern for rolling brownouts if the Salem plant is not built."Keenan said he doubted the bill would be taken up before the close of this year's formal sessions, which end next Wednesday. Formal sessions resume in January and run through July of 2014.
The committee also unanimously passed legislation (H 2945) that regulates double poles, which result when utilities prop up an older electrical or telephone pole with a new one but do not remove the old pole.


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Hertford Symphony Orchestra's Robert Kiln Concerts for Children
PUBLISHED: 20:38 01 February 2014 | UPDATED: 20:38 01 February 2014
The popular Robert Kiln Concerts for Children by the Hertford Symphony Orchestra (HSO) will take place on Sunday.
The orchestra's Creatures Great and Small concerts at Hertford Theatre, at 2.30pm and 4.15pm, will feature Roald Dahl's Three Little Pigs, with music by Paul Patterson.
Narrator Matthew Sharp studied cello with Boris Pergamenschikow in Cologne, voice with Ulla Blom in Stockholm and English at Trinity College, Cambridge.
He has performed at major venues and festivals worldwide as solo cellist, baritone and actor.
As writer, composer and performer, he collaborates regularly with leading artists from film, theatre and dance.
His music theatre works have toured to major festivals in Europe, India and the US.
Matthew is also the artistic director of the pioneering UK festival, the Deal Festival of Music and the Arts.
Tickets for Sunday's concerts cost £7 adults and £4 children.
They are available from the Hertford Theatre box office on 01992 531500 of by visiting www.hertfordtheatre.com
If you value what this story gives you, please consider supporting the Welwyn Hatfield Times. Click the link in the orange box above for details.


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Sachs Nazi-looted posters to auction in January
Sachs Nazi-looted posters to auction in January
Hans Sachs' extensive collection of Nazi-looted movie posters has been valued at $5.3m
Paul Fraser Collectibles,Thursday 20December 2012
A leading collection of pre second world war movie, advertising and propagandaposters, which were looted by the Nazis in 1938, are to auction in New York on January 18. The 3,600 posters are believed to be all that remains from poster collector Hans Sachs' original 12,500 piece collection.
Theremnants were returned to the Jewish dentist's son, Peter Sachs, in November 2012, from the Deutsches Historisches Museum following a court order issued from the highest court in Germany for civil affairs.
Although incomplete, the Sachs collection contains 3,600 posters
The posters' repatriation follows a period of revelation and attempts at resolution relating to property seized by the Nazis. In 2011, the US National Archives and Commission for Looted Art made an online catalogue of art works stolen by the Nazis available to the public.
The co-chair of the Commission of Looted Art in Europe, Anne Weber, said she considered the documents' release "a major step forward in international co-operation to help to solve these long standing issues."
Aslant to this, there have been further calls for the sale of Nazi memorabilia in the UK to be banned, as it is in France, Germany, Austria and Hungary.
The posters in question, which were taken from Sachs in 1938, were removed under an order made by Nazi propaganda minister, Jospeh Goebbles, who informed Sachs they were to be used as part of a museum exhibit.
Sachs, who was resident in Germany throughout the Nazi's rise to power, was subsequently arrested on November 9, 1938, during the Gestapo-coordinated pogrom of violence against Jewish citizens which is now known as Kristallnacht.
An 1895 chocolate advertisement from the Sachs collection
Taken to Sachsenhausen concentration camp, Sachs' wife secured his freedom soon after and the pair escaped to the US. Having accepted compensation for the collection in 1961, Sachs died in 1974 believing the posters had been destroyed.
Sachs' son Peter has expressed a desire that the posters stay together. They have been valued collectively at $5.3m.
For more auction news, please sign up for our free weekly newsletter.
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Windsor (City Of). Recreation and Culture
Site: Windsor - Gino & Liz Marcus Community Complex Indoor Pool - Drouillard Rd
Service: Indoor Pool
Add Record | Suggest Update | Print Version (New Window)
|Record #: WIN1382
|Last Modified: 16 Dec 2019
|Last Full Update: 16 Dec 2019
|Contact Information
|Office Phone
|General enquiries: 311
Office: 519-253-7028
|Toll Free Phone
|Primary Contact
|Kenn Little, Supervisor of Community Programming, City of Windsor, Parks, Recreation & Culture; Phone: (Business) 519-253-2135; Fax: 519-973-3984; Email: email@example.com
|Description and Service Details
|Description (Service)
|City-owned indoor pool, 18 metres long and 4 lanes wide
* part of pool/recreation centre complex
* recreational programs for all ages
* aquafitness
* lap swim times for lengths plus swimming lessons
* fitness centre
* banquet hall and full kitchen
* meeting rooms available
* offers a recertification clinic for Lifeguards and Instructors, CPR and First Aid
* Community Care Centre (offers residents easy access to some city services)
Rec Express Cards:
The easy-to-use, reloadable smart cards make gift giving easy. Load the card with any dollar amount and let the receiver choose from the hundreds of programs offered by Parks and Recreation: swimming, sports, arts and culture, birthday parties, room rentals, skating, etc.
The cards never expire and are easily available at all community centres, pools and arenas.
Rec Express Card
* A place people can go to cool off during times of extremely high temperatures
|Daily service, hours vary seasonally
|Areas Served
|Essex County
|* Everyone welcome
* Children birth-7 yrs unable to move freely in shallow water or non-swimmers must be accompanied by a responsible caregiver of 14 yrs and older
|* Registration process required for all programs
* Call or walk-in to register or register online via Rec Connect Click Here to Register Online
|Program - fees apply, seniors discounts ; Fee assistance available for discounts to qualifying families.
|Site Information
|Located In Community
|Address & Map
1168 Drouillard Rd
Windsor, ON N8Y 2R1
|Drouillard Rd and Richmond St
|Bus Routes
|Central 3 ; Ottawa 4
|Physical Access
|Fully Accessible - Parking, Washroom and Entrance
Still can't find a service? Call us.
Call 2-1-1, Toll Free: 1-866-686-0045


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The Path To Finding Better Entertainment
Video Gaming and its Advantages
Video games are usually played by most people as a form of entertainment due to the high levels of interaction they provide. Nowadays, electronic devices are portable owing to technology developments hence one is able to play video games from almost any location. Gamers get to interact on a social level by playing video games. Video games promote teamwork especially those that require multiple gamers to play against their friends as they team up to play against their opponents.
Sportsmanship attitude is also promoted as players get to work on their personal attitude. Social behavior is significantly improved on for those who love playing online video games as they interact with each other. While playing, gamers tend to talk to each other and encourage each other as well which promotes new friendships.
Strategy games and puzzles are some of the video games that help one to exercise their brains and muscles as well while they are entertaining themselves. Gamers are able to master new skills and revitalize their abilities which makes them very useful. Gamers are able to maintain focus and attention throughout the games which aids in memory training. Video games that help with analysis skills and training purposes are those that depict real life situations for gamers to maneuver. Some of the situations provided for gamers include driving of planes, cars and many more that apply the same principles in real life.
Gamers who are fond of video games are able to improve on their hand-eye coordination techniques. More focus on player reaction, accuracy as well as precision is paid to in most games that are developed. Such coordination comes in handy especially when one is faced with real life situations such as controlling objects. Gaming also works as a means of exercise for those who want to burn extra calories. The body movements that one exhibits during playing of video games helps to enhance fitness.
Though they are quite addictive, video games have a lot of benefits for kids and adults alike who like to play them. Learning institutions nowadays implement video games in their curriculums a teaching method. Children are thus able to develop cognitive and critical thinking skills which come in handy in their academic work. Playing video games for kids or adults alike provides endless possibilities for gamers to develop their imagination skills. There is a lot of adventure provided by video games that helps one's mind to start thinking in a new sort of way.
Successful gamers are those who have great problem solving skills that come in handy in order for them to win the game against their opponents. This way, they are able to strive and get to more difficult levels as the game progresses that pose more challenges unlike the previous ones.
Refer to: visit homepage


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- Specification-design
- Bid packaging
- Oversight/owners representative
- Contractor management
- Demolition management
Sub Services List
View Construction Management Problems Solved
Construction Management Services
LTE's Construction Management (Owner's Representative) and Construction Observation (Professional Engineer's Certification) services give our clients the confidence their project is getting built to spec, at cost, and on time.
LTE saves you money by being there; we are your eyes and ears in the field, providing prudent checks and balances. Because one hour of a typical culvert crew costs approximately twice as much as the daily rate for an on-site construction manager, we help drive down project costs by providing daily checks and field measurements to ensure accuracy in billing. The presence of our on-site teams helps the contractor increase efficiency and improve quality. As an additional value, LTE can offer different perspectives, trusted solutions, and innovative ideas to the contractor regarding construction methods, work scheduling, and traffic control.


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Herbal Healing Properties
Interest in herbalism has increased significantly in recent years, with a growing concern over the overuse of conventional drugs and a trend towards alternative and natural forms of treating illness, injury, and disease. Drawing on the fact that herbal remedies have been used successfully for millennia, dating back to ancient Egypt, Greece, Rome, and China, the health benefits of herbs are well documented.
Healing properties of various herbs (which originate from roots, leaves, barks, seeds, berries, fruits, and flowers) include:
- Antibacterial properties
- Antiviral properties
- High in B-vitamins
- High in trace minerals
- Contain disease-fighting antioxidants
- Contain essential oils
- Provide vitamins, mineral, and enzymes that support human health
- Help boost the body's immunity system
Herbal Remedy Benefits
Every herb has a distinctive flavor, energetic quality, and healing property with a corresponding healing effect on the body. For instance, marshmallow root with its cooling properties is used to treat high fever, rapid pulse, and excess heat in the body; cinnamon bark and dried ginger are known for their warming and stimulating properties.
Additional health benefits of specific herbs and spices include:
- Cinnamon: High in antioxidants; reduces inflammation; lowers/regulates blood sugar and blood triglyceride levels; alleviates nausea; increases sensitivity to insulin; provides calcium, iron, and magnesium
- Garlic: Aids in reducing blood pressure and cholesterol; improves cardiovascular health; being studied for its anti-cancer properties
- Basil: Anti-inflammatory and antiviral properties; helps with digestive disorders and prevention of osteoarthritis; being studied for its anti-cancer properties
- Arrowroot: Highly digestible; known for its soothing effects; used to treat digestive disorders and conditions such as Irritable Bowel Syndrome
- Dill: (Weed/Seed) Known for its antibacterial and stomach-settling properties (making it popular among pregnant women who crave pickles)
- Cayenne: Increases circulation, reduces risk of heart disease, improves absorption of other nutrients
- Mint: Alleviates nausea; calms digestive troubles; contains essential oils; can be used to repel mosquitoes
How Herbs Are Dispensed
Herbs can be dispensed in numerous ways, including:
- Pills
- Powders
- Lotions
- Oils
- Teas
- Salves/Ointments
- Syrups
- Infusions
- Aromatics
- Juices
- Tinctures or extracts
- Whole (dried or fresh)
How to Find a Licensed Herbalist
To find a licensed herbalist or naturopath in your area and for advice on the best herbal remedies and natural treatments for your body, contact the American Association of Naturopathic Physicians or the American Herbalists Guild.


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Singapore Property | With a strong sale of private homes in October 2017, developers should end 2017 on a high note just when the government warned that it could intervene to reduce the overexcitement in the property market.
According to Nov 16 URA data, there was an increase of 7% in October sales of new private homes and ECs to 969 from what was recorded in September.
The month of October also had more units launched at 242 units an increase from the 73 units launched in the previous month.
Excluding Executive Condominiums (EC), there were 758 private homes sold in October, an increase of 15.4% from the units sold in September, based on URA data.
The top sellers in October were projects launched earlier that include GuocoLand's Martin Modern, Sophia Hills a joint development by Sunway Developments and Hoi Hup Realty as well as iNZ Residence by Qingjian Realty.
"With few new launches that buyers can select from, they continued to buy homes from projects launched earlier", observed Tricia Song head of research and director Colliers International Singapore.
Indicating the improved outlook for the high-end units, October's private residential projects that were top-sellers were in the CCR. Sophia Hills in District 9 had 62 units that fetched $2,029 psf average price while Martin Modern in the same area had 47 units sold at an average price of $2,343 psf.
On October 2 low-key projects that were launched included Roxy-Pacific Holdings' The Navian, in which 24 of its 48 units were launched and 12 were sold at $1,543 psf average price and Lim Wen Heng's Carpmael Thirty-Eight that had 16 units launched.
The Outside Central Region or the suburban region took 44% of the private homes that developers sold in October. However, it was in the Core Central Region that there was the highest rise in transactions of 143% to 141 homes in October 2017 from what was recorded in October 2016. Ismail Gafoor, CEO PropNex Realty, credited this to price.
"The property prices today in the CCR of from $2,000 and $2,300 psf are seen as very attractive since the 2018 new launches in the RCR are forecasted to go over S$1,700 psf and therefore narrowing the gap in price between the 2 regions", said Ismail.
Majority of market watchers do not expect the demand for residential property to dampen.
However, Lee Nai Jia research head Edmund Tie and Company felt that Lawrence Wong, National Development Minister's latest remarks to parliament that the government intends to interfere if there were too much heat in the real estate market to keep it stable, could affect the buying sentiment.
Even so, while the month of November and December may have seasonal easing when traditionally there are fewer launches, the Parc Botannia release, a 735-unit project by Wee Hur and Sing Holdings on 11 November and whose 230 units were sold in that 1st weekend is anticipated to boost November sales.
For the whole year, consultants are expecting developers' primary new homes sales to reach between 11,000 and 12,000 units without executive condos or between 15,000 and 16,000 including ECs.
In 2016, developers sold 3,999 ECs and 7,972 private residential homes.
If you are interested to read on more future launches, you may visit Belgravia Villas Phase 2, a strata landed development or the Luxus Hills new phase, a landed development.


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There are four main ways of coming to the Past Life Regression phenomenon.
Many people hear of past life regression and past lives and consider the whole idea a little fanciful, or even absurd. These kind of reactions are often encountered by those working with transpersonal psychology, and in areas which don't fit in with present day statistical driven scientific approaches.
However, there are different ways of looking at the whole area of past life regression ...
1) The Psychic: Some individuals feel they can reach channelled teachings through connecting with spirit guides. This is where past life readings are undertaken through mediums.
Here there is a profound belief in the soul journeying from life time to life time and through medium readings you can find the 'whys' and 'hows' for your life's challenges.
2) The Parapsychological: This is the scientific and experimental investigations into past lives, looking for evidence to prove the phenomenon exists.
Dr Ian Stephenson is probably one of the best known collectors of scientific data looking to provide scientific evidence for reincarnation.
He collected 3000 case studies of individuals who described having awareness of a past life including significant information that identified that past life, and included knowledge of how they died. These were then verified.
3) The Religious: Eastern traditions are complex. Taoism, Buddhism, Hinduism, Islam, spiritual authorities with generations of insights and teachings to share.
Karma, the psychic inheritance and accumulation of mankind's thoughts and actions as passed on through the great cycle of rebirth.
4) The Psychotherapeutic: Belief in the existence of past lives is irrelevant. All that is needed is an awareness of the healing power of the unconscious mind.
The Past Life Transpersonal Therapy technique has shown time and time again to create profound changes in people. It uses the active imagination, developing a life story to death to get to the suffering that is causing present day symptoms or challenging events.
It works at a high level of consciousness and connects with the deeper sense of ourselves, in an imaginal way. It helps deepen self-understanding and healing with the focus being on the person and not whether the event in the past actually existed or not.
Believe in Your Imagination
We look at these various perspectives in more detail in the book. The main point though, is that believing in past lives is not necessary. Simply believing in the power of the creative imagination and an openness to possibilities is.
Find out more in Healing from the Other Side: The Guide to Breaking Down Barriers and Finding Freedom with Past Life Regression Therapy or delve even deeper on our Past Life Transpersonal Therapy™ certified course.
Originally posted 2018-07-10 16:43:04.


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0844 824 9187 email us
Lite House Europe Ltd, The Atrium, 100 The Ring,
Bracknell, RG12 1BW, UK
A new line of Led Accent lights, affording a small and slick design and leading-edge technology. The series of spots includes both recessed and free-standing fixtures.
This range of small compact Accent lights have a smart design, incorporating a unique cooling method, and a concealed cable PG, to provide a slim cutout where its anodized color lends the final touch of an artist.
Ideal for illuminating facades and niches, spas and pool areas, landscape
Lighting and scenery, counters and shelves, indoor and outdoor use, at home and/or in the office.


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The mineral products industry covers a broad span of industrial activities which range from energy-intensive processes like manufacture of cement and lime to the production of aggregates and ready-mixed concrete involving relatively low emissions per unit of production. There is universal acceptance right across the industry of the need to control and reduce its carbon footprint. Progress to date in the cement sector has been particularly encouraging with a reduction in emissions of carbon dioxide per tonne of cement manufactured of 21% between 1998 and 2012. Other areas of the industry each have their own initiatives.
While manufacturing and delivering our products inevitably generates carbon, the products themselves often have important roles to play in actually tackling climate change. Concrete structures, for example, have unique thermal mass characteristics that help to moderate temperature changes in buildings and reduce the need for air conditioning. Mineral products will be an integral part of the low-carbon energy generation capacity that will be developed over the next decade and are equally in the front line in the battle to resist floods and to hold back rising sea levels.
I want to pay huge tribute to your industry for being not just way ahead of the rest of the world here in the UK in thinking seriously about re-use, recycling and how to use resources better, but also about how to reduce your carbon footprint and how to ensure the impact on climate change of this essential industry can be minimised."
Lord Smith, Chairman, Environment Agency


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Now showing items 1-2 of 2
Relative abundance and population biology of the non-indigenous crab Charybdis hellerii (Crustacea: Brachyura: Portunidae) in a southwestern Atlantic estuary-bay complex
(Aquatic Invasions, 2012-09-01) [Artigo]
Invasive species are potential threats to biodiversity, especially if they become established and outnumber native species. In this study, a population of the non-indigenous crab Charybdis hellerii was analyzed in an ...
SPERMATOGENESIS, SPERMATOPHORE, and SEMINAL FLUID PRODUCTION IN THE ADULT BLUE CRAB CALLINESTES DANAE (PORTUNIDAE)
(Journal of Crustacean Biology, 2012-03-01) [Artigo]
Sperm and spermatophore production in Callinectes danae Smith, 1869 were examined by histochemistry and correlated with gonadosomatic (GSI) and hepatosomatic (HSI) indices. The GSI from developing (DE) and mature (MAT) ...


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Yes, winter is coming…
As the weather begins to cool, we are all reminded that we need to get our furnaces or other heating appliances ready for winter.
Fuel-burning appliances like water heaters, furnaces, dryers, stoves, and fireplaces require fresh air intake to burn efficiently and safely.
Without proper venting, the use of these appliances could lead to the risk of buildup of deadly carbon monoxide in your home. Check the chimney and outside vents for leaves, nests, or other debris that could block air flow. Performing these tasks now before the heating season gets into full swing can help ensure safe and efficient operation.
It is a good idea to have your furnace and appliances regularly inspected and services by a qualified contractor. For everyone's safety, book an inspection and tune-up today. If your home does not have carbon dioxide detectors, consider having some installed to ensure peace of mind.
Stay safe as winter approaches.


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Located on the second floor this apartment has easy access to the stairs leading to the roof terrace or courtyard below. It is one of our small studios that are cozy, functional and convenient. It also has great natural light with a window and large door to the walkway.
This apartment is perfect for one person but can accommodate two. It has a double bed, kitchenette, bar table, small bench, wardrobe and spacious bathroom.


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Registration Starts April 22 for parks located WEST of California Ave. & April 23 for parks located EAST of California Ave. at 9 a.m.
Get your checklist ready before registration HERE.
Featured in the April Newsletter:
- 85th Anniversary Birthday celebrations, which kick off on May 1st;
- April Contests.
View the Newsletter at:


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No subsystem
IDEA-104465 (Usability Problem)
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IDEA-104371 (Bug)
persistence generation creates setters/getters as package level NOT public
IDEA-102296 (Usability Problem)
project.properties getting set to transient values
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Fix "unsupported class files format" quickfix in the preview
IDEA-102326 (Bug)
Can't handle R.fraction.xxxx
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Refactoring Android Styles
IDEA-104413 (Bug)
Style renaming: the IDE doesn't update reference in "parent" attribute
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Style renaming doesn't take into account explicit parents
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Something causes UI slowdown/freeze while reimporting maven projects
IDEA-101024 (Bug)
Android: every other artifact Rebuild fails
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Fragment marked as Not used if only referenced in layout XML
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[Android] Show error on correct code
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Android Tests run configuration incorrectly highlights class as inaccessible
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Project Settings - Android Facet - Fields in structure (Manifest file, Resources directory) are reset when I select another profile or edit my pom
IDEA-97260 (Bug)
External build with parallel modules fails with AJC (aspectjtools 1.6.12)
Code Analysis. Inspection
IDEA-104173 (Feature)
Show more of file path in inspection
IDEA-104448 (Usability Problem)
"Redundant type argument" warning does not match inspection name "Explicit type can be replaced with <>"
IDEA-96859 (Bug)
Unused import analysis doesn't work.
IDEA-104858 (Bug)
"Replace constructor with factory method" fails on generic classes with default constructor.
IDEA-96741 (Bug)
False positive inspection GroovyIfStatementWithIdenticalBranches, when both branches contain assertion with the same condition
IDEA-105004 (Bug)
bad code is green: static class extends non-static
Code Navigation
IDEA-104906 (Feature)
Show Enum ordinal somewhere
IDEA-103549 (Cosmetics)
"Go To Action/Settings": mnemonic results in space of option name
IDEA-51629 (Bug)
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IDEA-58911 (Bug)
Parameter Info popup (Ctrl+p) highlights incorrect overloaded method with primitive arguments
Compiling Project
IDEA-94093 (Feature)
Need statistics for new make
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Cannot compile single class
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"Jump to source" from stack trace jumps to wrong line in file when using keyboard shortcut (fine when using mouse)
IDEA-104980 (Feature)
Ability to view multiple SQL Server databases in the database view and get autocomplete for them as well
IDEA-105210 (Bug)
Database console query never returns - wormhole busy animation continues
IDEA-105171 (Bug)
DB support for Hive/Thrift client
IDEA-105389 (Bug)
Database: SQLServer: synchronize on one schema updates all
Editor. Editing Text
IDEA-103915 (Bug)
Cannot use "surround with" to create a custom code folding region
File System
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Update Snappy to 1.5M2
Find, Replace, Find Usages
IDEA-105396 (Bug)
Find usages: scope chooser combo jumps over two lines by keyboard
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Flash Run configuration: pass arguments in right order
IDEA-105046 (Bug)
Android package (*.apk) created with AIR SDK 3.7 always includes captive runtime, so IntelliJ IDEA shouldn't suggest to install AIR Runtime on the device.
IDEA-96170 (Bug)
IntelliJ IDEA always adds -profile extendedDesktop option to adl command line, but should respect <supportedProfiles> option in custom AIR descriptor instead
IDEA-66646 (Bug)
flex binding errors and noname.as
IDEA-105343 (Bug)
IDEA does not suggest to create empty test method stubs for setters
IDEA-105024 (Bug)
"Loading External SWFs" feature of AIR SDK 3.7: 'externalStrippedSwfs' folder is created in [IntelliJ IDEA installation]/bin. Should be created in the output folder.
IDEA-104332 (Bug)
Auto suggest not working for native methods of "Object" class
IDEA-105206 (Bug)
Single Grails test cannot be executed. Always all tests are executed
IDEA-101777 (Usability Problem)
Complete statement problem
IDEA-99681 (Bug)
Groovy: don't suggest static members of the same name from super classes
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Groovy: insert getter with line feed
IDEA-104162 (Bug)
Groovy: create constructor matching super should add corresponding imports
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Groovy inspection "Assignment to method parameter" behave incorrectly
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Groovy code completion seems to infer the correct type but documentation popup states "cannot infer type"
IDEA-105292 (Bug)
IDEA 12.1.1 doesn't allow abstract methods in groovy enums (new feature in groovy 2.1.3)
IDEA-93723 (Bug)
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IDEA-93726 (Bug)
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IDEA-105357 (Bug)
Griffon: @PropertyListener annotation
IDEA-103082 (Bug)
Create New Test for Groovy JUnit does not annotate the new test methods with @Test
IDEA-105246 (Bug)
Groovy: "Incompatible type assignments" marks correct code as invalid
IDEA-104786 (Bug)
"Convert To Java" refuses to convert groovy file
IDE Configuration
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Copyright Format Settings Not Saved
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Create Servlets without present web.xml
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Struts 2: <param> "name" in <result> should resolve to Action's class properties
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UnusedDeclaration Inspection using Convention plugin for Struts 2 Action Class
Java. Error Highlighting
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Java 8 support: repeating (duplicate) annotations
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No error is shown for non-constant value in annotation usage
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Static method highlighting
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Java. Intention Actions
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"Extract If Condition" quickfix has too long name
IDEA-105275 (Bug)
Create multiple if's intention generates wrong code
Java. Refactoring
IDEA-104485 (Usability Problem)
Introduce variable suggests inapplicable expressions
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Make inner class: incorrect accessibility warning about inner class
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Maven filtering in IDEA 10.5.2: settings.localRepository is not substituted
IDEA-103600 (Bug)
UNDO error: Whenever I entered ctrl+z, this always worked. Since the last 2 EAP versions it is problematic
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12.1 looses the ability to extract a field in a JUnit test and initialize the field in the setUp method
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TestNG integration doesn't inherit @Test from parents
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IDEA-103903 (Feature)
AutoTest for Ruby/Python/etc. plugin in IntelliJ IDEA.
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IDEA-102320 (Usability Problem)
The darcula scrollbar thumb is hard to see
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Darcula: Update Info dialog invoked from Welcome Screen cosmetics
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Darcula - Number steppers look terrible
Content Tools


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Cancelled trains leave football fans stranded
PUBLISHED: 19:49 29 December 2018 | UPDATED: 08:52 30 December 2018
Trains between Norwich and Diss have been cancelled, leaving many football fans stranded as they try to make their way to Carrow Road.
Disruption is expected to continue on trains travelling between Norwich and Diss as footballs fans and shoppers attempt to leave the city.
Greater Anglia said a signalling fault was discovered around 2.20pm between Wymondham, Diss and Norwich and services travelling between the stations were cancelled.
A Network Rail engineering team arrived on site at 3.15pm and announced they had found a temporary fix three hours later.
However they added that delays were likely to continue until around 9pm.
David Pegg, 67, had prebooked a ticket for the 2.40pm service from Norwich to Attleborough but was delayed for more than an hour.
He said: "It feels like every week something goes wrong. There's a lot of very annoyed and cold passengers here at the moment."
A spokesperson for the train company said: "Greater Anglia and Network Rail are sorry if your journey has been affected by this disruption."
"Advance purchase tickets holders will be allowed to travel on earlier or later trains if their booked service is cancelled."
The cancellations hit football fans travelling from Diss to Carrow Road for this afternoon's match, with some reporting they missed the game as a result.
One football fan, travelling from Diss to Norwich, tweeted: "@NorwichCityFC all trains cancelled from Diss and Cambridge can't get to the game."
In a tweet, Greater Anglia said passengers delayed more than 30 minutes were entitled to claim compensation via their website.
If you value what this story gives you, please consider supporting the Norwich Evening News. Click the link in the orange box above for details.


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One of the most fascinating things to watch as a Wall Street reporter is the emergence of new technologies, and attempts to fund them. Biotech was the big one a decade ago, but now there are others: robotics, genetics, artificial intelligence, and now nanotechnology.
These technologies can and will be enabling--that is, they will assist companies to improve existing products and offer (startlingly) new products in the near future, but they will also likely be disruptive of many business plans.
A new research firm started up last week. iNano Capital Advisors is a registered investment advisor in Florida focusing exclusively on nanotechnology. Nanotechnology attempts to manipulate structures at the atomic level, and it has the potential to change whole industries. A nanometer is a billionth of a meter, about the size of six carbon atoms in a row.
The firm is run by Arthur Pacheco, a former president of the Securities Traders Association with a long history in the securities industry. The firm is partnering with research institutes and universities like the Smalley Institute at Rice University, which is the oldest and most respected research institute in the nanotech field, as well as the Alliance for Nanohealth, which is a research partnership of eight medical centers and colleges that do research and development.
But iNano wants to be more than just an institutional research firm. They want to nurture nanotech firms and expose them to the investment community.
They will produce research on a universe of about 200 stocks that will be directly impacted by developments in nanotchnology. The research will discuss stocks as diverse as Kimberly Clark (who are interested in developing better fibers) to medical technology companies (nanocoatings for stents to make sure they are not rejected or to decrease the possibility of infection) to our parent, General Electric , who are making a large investment in R&D for nanotech.
What about investing in nanotech? Two problems:
1) right now, it's difficult to play nanotech directly, and
2) the science is extremely complicated and involves a lot of cross-disciplinary work. This has led a lot of investors to get discouraged by the sheer complexity of the business.
That's a mistake. This technology will--along with artificial intelligence and the advances in genetics--change the world.
But all ventures begin modestly. iNano just initiated coverage on their first pure-play nanotech investment, Harris and Harris Group with a buy recommendation. Here is a link to the report.
I'll keep an eye on them, and other companies with their eye on these disruptive technologies.
Questions? Comments? email@example.com


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Sep 19, 2017
This show is being uploaded two days before my favorite day of the year … my own personal holiday and a cause for celebration. Yes, it is my Birthday. September 21a date that will live on and on thanks to Earth Wind and Fire's classic, September (listen to the first show).
Join Jean and I and my bestie Tawanna as we discuss birthdays, how we celebrate, why some people don't and why aging gets such a bad rap. After all, if we're lucky, we all will get older and there are benefits to it.
Listen and stop by the website to read the birthday blog: http://www.funfeistyfab.com/birthday-time-lets-celebrate-or-not/


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Just goes to show how powerful good design can be. We explore this brilliant water tower home that was once a Nazi tower.
Looking at the seemingly spacious interior of this unique home located on a flat of land just outside Steenokkerzeel, Belgium, it's difficult to imagine that in its former life, the cozy abode was a 75 year old water tower.
The guy behind the switch is Bham Design Studio's own Mauro Brigham. What was once a Nazi watchtower has been completely renovated; concrete columns repaired, brick joints removed, and windows enlarged. It is now a picture perfect, high tech modern living space that boasts all the amenities of a typical house, featuring many of the best finishes money can buy.
Every room in this grand, column-shaped home is equipped with the latest in IT technology, with the ability to connect a projector in almost every room in the top level, the floor containing the living room and kitchen.
This is not purely for the benefit of the couple that lives here on a day-to-day basis, but to attract high profile businesses to rent this space for their conferences – the benefits, of course being the view, the wow-factor, and the proximity to the airport. Also in place is a domotics system, which controls various facets of the home, including the intensity and color of the lighting, as well as the temperature and the sound system.
All the concrete in this building was painstakingly preserved to retain the structure's strong identity, and the result is an amazing architectural feat that has beckoned fans of unlikely renovations and modern décor.
Starting at the ground floor, where the main entrance and two-car garage lies and then moving up to the first floor is the home's technical room and primary storage area. On the second floor, visitors can find a guest room and an office.
The third floor is where things start to get interesting. The main bathroom has a 4.5 meter high shower, constructed to provide the best water flow, and is surrounded by tinted glass for privacy. No worries about anyone being lost in the dark while they're in there; these circular rooms are bathed in light from almost every direction.
The fourth floor features the modest main bedroom, accentuated by a dome ceiling and a revolving staircase that leads to the top floor, which is arguably the most extravagantly put together floor of the whole home.
Here we are. This fabulously modern living room, sculptural kitchen, and dining area take up a large portion of the top floor, and the metal bridge takes you up to the gorgeous panoramic terrace. The elevator block located here also has another smaller bathroom, a library, a cat house, and a coat room.
Taking the aforementioned metal bridge up to the panoramic terrace, you will find a fabulous view of the handy little yard, raised wood flooring, and … a shower? It is a water tower, after all.


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Senior Health Channel
Topics & Medications
Related Channels
Drug Interactions With Aflibercept
Aflibercept (Eylea™) is unlikely to interact with most other drugs. This is probably because aflibercept is injected directly into the eye and only a small amount reaches the bloodstream. Because most of the body is exposed to very little aflibercept, drug interactions are not likely to occur. However, it is important to understand that this product has not been thoroughly studied in combination with other medications, so it is possible that there are aflibercept interactions that are currently unknown.
Talk with your pharmacist or healthcare provider on a regular basis about specific drug interactions with aflibercept that may apply to you. Make sure each of your healthcare providers has a complete and current list of all of the medications and supplements you are taking, even the ones that do not seem important enough to mention.
Aflibercept Drug Information
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD


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| This article or section contains information regarding scheduled, forthcoming or expected future Minifigure(s).
The content may change as the release approaches and more information becomes available.
The Rocker Girl is an upcoming Collectable Minifigure to be released in 2012 as one of the sixteen minifigures from 8831 Minifigures Series 7. She has pink hair and a pink lightning bolt on her face. Her outfit is blue, pink, and black. She will have the same guitar from Series 4's Punk Rocker, only it will be white, also with a pink lightning bolt.
- She seems to be designed similar to the old 80's cartoon character Jem.
- She is the second minifigure with pink hair, the first being the Punk Rocker, both the same shade of pink.


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Weekly Vocations Posts for Parishes 2019With 0 Comments, Category: Discerning Priesthood, News and Events, Planting seeds, Vocations, Vocations Campaigns,
Bulletin and Website Notices for Vocations
Sundays in Ordinary Time 2019: Weeks 14 - 34
As we did in the earlier part of 2019, we continue to offer here some short reflections for each Sunday and major feast day for the remainder of the year.
Taking as their starting point some element of the day's Scripture readings, in particular the Gospel of Luke which guides us through this Liturgical Year, they offer a reflection question for anyone who might be thinking - however loosely! - about the possibility that God might be calling them to priesthood or religious life. Indeed, they can be relevant for anyone considering any kind of vocation in the Church priesthood, whether diocesan, religious or missionary, consecrated life, or diaconate.
Please feel free to copy and paste these brief reflections into your weekly parish newsletter or other publications. You may want to copy and paste them onto your parish website as a banner message or news item, to place a link to the page as a whole from your website, or to use them as Facebook posts on or around the relevant Sunday.
(Note: Some of the texts are a little too long to serve as Twitter posts, but they can be edited by removing the email contact and some of the repeated contact information as desired.)
Below are the first two suggested posts. The rest can be found here.
14th Sunday of the Year – July 7th 2019
"The harvest is rich, but the labourers are few." Could you be one of those Jesus sends to preach the kingdom and bring his healing, as a priest, religious or deacon? Call your Diocesan Vocations Director, or email Priests for Scotland at firstname.lastname@example.com. See www.priestsforscotland.org.uk or visit our Facebook page.
15th Sunday of the Year-- July 14th 2019
"The Word is very near to you; it is in your mouth and in your heart." Perhaps you feel a desire to share God's word with others. If you feel you may be called to the priesthood or religious life, call your Diocesan Vocations Director, or email Priests for Scotland at email@example.com. See www.priestsforscotland.org.uk or visit our Facebook page.
Click here for the page where you will find all the prompts for the Sundays and feasts through the weeks of Ordinary Time until the Feast of Christ the King 2019.


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Cancer Research Roundup: Deciphering Keys to Cancer Response Kicks Off National Cancer Research Month
All of the key advances made in the prevention, detection, and treatment of cancer over the last several decades would not have been possible without the significant investment in cancer research – research that moves from basic discoveries of the molecular drivers of cancer to translation of these findings into the clinic to development of large-scale clinical trials.
During the month of May, we celebrate National Cancer Research Month.
We will highlight recent research accomplishments from the University of Chicago Medicine Comprehensive Cancer Center investigators and how our patients have directly benefited from broad investment in cancer research. We will also include a banner from the American Association for Cancer Research's month-long campaign to raise awareness of the need for research funding.
As a kickoff to this series, we share four recent studies that shed light on the mechanisms by which tumor cells respond to various types of therapies and innovative strategies to develop more effective treatments.
Deciphering the Keys to Cancer Therapeutic Response
A major challenge facing oncologists is the lack of tools for predicting how patients will respond to specific chemotherapeutic agents or targeted therapies in terms of both eradicating their disease and preventing side effects.
Researchers at the University of Chicago Medicine Comprehensive Cancer Center are tackling this problem from multiple angles, including dissection of the genetics and molecular pathways involved in determining therapeutic sensitivity, as well as developing more effective novel therapy combinations. The goal is to translate these pre-clinical and early-stage clinical findings into clinical practices to aid oncologists in decision-making and, ultimately, produce better outcomes for patients.
In a recent paper published in Science Translational Medicine, a research team led by Philip Connell, MD, associate professor of radiation and cellular oncology, and including Ralph Weichselbaum, MD, D.K. Ludwig Professor of Radiation and Cellular Oncology, explored the role of DNA repair pathways in determining patient response to platinum-based chemotherapy drugs.
They developed a novel methodology for quantifying the efficiency of DNA repair pathways and generated a recombination proficiency score (RPS) based on the expression of four genes (Rif1, PARI, RAD51, and Ku80) involved in DNA repair.
Analysis of patients with breast and non-small cell lung cancer revealed that tumors with low RPS were associated with higher levels of gene mutations, adverse clinical features and decreased survival rates.
Importantly, the ability of the RPS to predict the sensitivity to platinum-based chemotherapy was validated, specifically that treatment significantly improved the 5-year overall survival in low-RPS tumors but not in high-RPS tumors.
Therefore, the RPS may be a new, powerful tool to help oncologists select therapies that would be the most effective and appropriate for individual patients. (Pitroda et al., Sci Transl Med 6:229ra42, 2014)
Two collaborative projects have been recently published that specifically address the impact of an individual's genetic make-up on the response to chemotherapy and uncovered new targets to modify drug sensitivity.
A study by Eileen Dolan, PhD, professor of medicine, and involving Kevin White, PhD, professor of human genetics, identified novel relationships between protein factors, genetic variants and sensitivity to paclitaxel and cisplatin, two commonly used chemotherapeutic agents.
Beyond their large-scale approach analyzing hundreds of signaling proteins and transcription factors and using dozens of cell lines, the research team functionally validated two genes, SMC1A and ZNF569, which are associated with sensitivity to cisplatin and paclitaxel, respectively. (Stark et al., PLoS Genet, 10:e1004192, 2014)
Stephanie Huang, PhD, assistant professor of medicine, and Nancy Cox, PhD, professor of medicine, collaborated to develop an integrative approach to combine genome-wide genetic, gene expression, and microRNA expression to determine the molecular basis for carboplatin and cisplatin sensitivity.
They identified five single-nucleotide polymorphisms, or small gene changes, associated with 10 miRNAs and the expression level of 15 genes, all of which were linked to carboplatin sensitivity.
Functional studies confirmed that two candidates, ABCD2 and miR-30d, robustly controlled the response of ovarian cancer cells to cisplatin, and did so by working together. (LaCroix et al., BMC Genomics 15:292, 2014)
Maciej Lesniak, MD, professor of surgery, and his research team have been exploring ways to optimize the therapeutic response for glioblastoma multiforme (GBM), the most common form of malignant brain tumors in adults, and one that is particularly challenging to treat.
They recently reported the effectiveness of a novel triple-combination immunotherapy in GBM preclinical models. Specifically, the combination of inhibiting indoleamine 2,3 dioxygenase 1 (IDO), CTLA-4 and PD-L1, all of which control tumor-infiltrating immune cells, resulted in potent antitumor activity and long-term survival in animal models.
This study provides critical proof-of-concept evidence to pursue this therapeutic strategy in patients with GBM in early-phase clinical trials. (Wainright et al., Clin Cancer Res Apr 1 Epub ahead of print, 2014)