text:
A Call To Reason.
A Safer Disclosure. For years co-ops have been requiring prospective buyers to submit all sorts of intensive paperwork and now condos are getting into the act. Prospective purchasers, particularly in this age of identity theft, are understandably quite alarmed by this incredible invasion of privacy.
Money is a highly sensitive subject and other than in an application to buy a co-op, most people keep their cards VERY close to their chest. However when buying a co-op applicants are required to submit every detail of their financial life for fear of being rejected or even worse, losing their downpayment.
"And how many copies do I really need to submit?"
What happens to those copies? A mystery for sure but one would hope, for the safety of the applicant and the liability of the co-op and its board, that all copies are promptly and properly shredded.
But whose to say some perverted board member doesn't keep the materials for use at a later date? How can that be prevented? In today's age anyone with a $100 scanner can distribute someone's entire financial portfolio to the entire planet in about 30 seconds.
And the kicker to all this is that the board members receiving this vital private information quite often do not have the ability to evaluate it. Very few are accountants or have any real knowledge of what is in or, even worse, missing in a financial statement or whether particular investments make any sense. So the buyer has his entire $1,000,000 portfolio in a company that builds nuclear power plants in Japan or in another high-risk investment. Is that good?
What to do?
Here is a simple and practical solution.
Have the financial material submitted to an independent accounting firm with knowledge of the co-op's requirements. The buyer would pay for the review. The accounting firm would determine, based on the particular board's standards of income and financial strength, whether the buyer meets these standards or not or what it would take for the buyer to qualify (for example should there be a guarantor or an agreement to put in escrow up a year or so worth of maintenance). The accounting firm would be bound to destroy all financial information.
In this simple solution, shareholders need not worry that the neighbor who smirks while saying "Good Morning" in the elevator knows their entire FINANCIAL life. They need not worry that the psychopathic board member may have retained copies of their most sensitive materials or that some person with absolutely no knowledge of reading financial materials holds all the cards in determining whether he or she is qualified to buy their dream home. In short, one's neighbors will not see the results of this financial colonoscopy.
This would work particularly well in re-refinancings. Many co-ops require a full set of financials when existing shareholders seek to refinance their loan especially one that takes out more money. In these situations, embarrassing and or sensitive information need not be circulated among one's neighbors.
A downside to this solution would be that board members would have some of their power diminished and would have to satisfy their curiosity fetishes elsewhere.
But remember board members, Curiosity Killed the Cat. Just think of how many prospective buyers would not shy away from co-ops and what that increased demand would do for co-op prices.
Of course this would not diminish all review by the Board. They would still be reviewing the prospects' history (are they litigious, do they have a history of disputes with their past neighbors, etc.)
On the other hand, board members would not have to waste their time reading and analyzing boring and often misleading financial information and could spend their time and energy doing the real business of running a building.
I think it's high time that the process of buying a co-op be made more palatable
Category: Board Packages, News, Simple Solutions Comment »


text:
I've been wanting to write about this for a long, long time – my Top 10 things NOT to do in your garden! Having designed gardens for over a decade, I've seen a lot of crazy things; some funny, some not so much.
Please join me today, along with the rest of the Garden Designers Roundtable, as we discuss the topic 'Reality Check – don't do this'!
1. Neglecting to mulch (or…"pssst! Your tubing is showing")
Many of you already know that adding a top dressing of mulch is a great idea, as it suppreses weeds, helps your soil retain moisture, and keeps the soil at a consistent temperature. However, it's not a 'put it down and forget about it forever' sort of thing! You'll need to add more to your garden every few years (more often if tend to go crazy with the blower, scattering it to kingdom come). Yes, it can get expensive. And yes, it can be labor-intensive. But if you don't, this is what you end up with. And after going through all the effort of creating your garden, is this really what you want to end up with?
2. Don't strangle your trees
Guy wires like these definitely help support young trees as they grow strong enough to withstand strong winds.
But please remember to take them off after a few years. Otherwise, the tree will continue to grow around the wires and eventually begin strangling itself.
Definitely not a good thing for the health of your tree!
3. Stairs that stab
After having a falling out of sorts with their 'contractor' (and I use that term loosely!) these homeowners called me for help. This is just one example of this contractor's handiwork. Now who in the world would ever want to walk up stairs that are as dangerous as these? I wonder how many times their poor kids impaled their ankles as they bounded up the stairs?
And the grout? C'mon! There was no effort put into matching the color with the stone, and it's way too wide in sections. Sorta just globbed in there.
Needless to say, we gave the stairs a make-over.
4. Beware of monster vines
I know those vines look beautiful sitting their 5-gallon containers at the nursery. But please, please, read those tags! When the tag uses words like 'energetic' and 'vigorous' it's usually an understatement. Those words are clues that the vine will quickly smother your home if given half a chance. Wisteria and Trumpet Vine are classic examples of this, as I commonly see these vines scrambling up the tallest trees hoping to reach for the moon.
5. Beware of monster agaves
I love agaves as much as the next person but, again, remember to read those tags! There's so many varieties of agaves out there, available in so many sizes, remember to match the size to the space. Time and time again I see a giant Agave americana planted next to a pathway. Remember. these plants are GIANTS with sharp points on the end, just waiting to spear the poor person who loses their balance.
And not only that, they send out tenacious runners like you can't believe. You'll be forever ripping these runners out of your garden, which is fine with agave-lovers, but not fine when planted near hardscaping. The runners have Herculean-like strength and can push through asphalt with ease.
6. Speaking of asphalt….know when to stop
There's no need to use asphalt like a blanket, tucking in each plant for eternity.
A plant's roots need air to breathe, need water from the rain, need nutrients from decomposing mulch – not asphalt!
Besides, as the plant grows, it'll expand and break apart the asphalt leaving you with a most unsightly mess.
7. Butchering phormiums
Poor, poor phormiums, they're forever being butchered and manhandled into a size they just don't want to be. This could also fall under the category of 'read those plant tags' as there's so many varieties of phormiums out there in so many different sizes. From the giant p. atropurpureum (towering to 8 feet) to the diminutive p. 'Jack Spratt' (topping out at 1-2 feet) choose a phormium that's right for the space.
Phoriums really don't need to be pruned at all, except for a few old and tired leaves at the base of the plant. So when the right variety is in the right space, you'll never have to look at this.
8. Redwood mayhem
Redwoods abound here in Northern California, but more often than not they're planted waaaay too close to a home's foundation. Small, suburban properties are no place for this mighty tree. Remember, the average size of our coastal redwood is 250 feet. That's 250 feet PLUS!
So, while you might think it's a good idea to use a fast-growing redwood as screening from your neighbor, if you plant it near a fence, wall, foundation, driveway, etc. you'll be sorry.
The Mighty Redwood will always win
9. Use it or lose it
When looking at your garden, or considering a new design, give some thought to the lawn you want to include. Are you really going to use it? Or is its purpose to sit there like a prized patch of labor-intensive, water-chugging green that you're only including because you don't know what else to do.
Now I'm not one to rant against all lawns, as I have one myself that my family uses and enjoys just about every day. But for the most part, a lot of the lawns I see out here are unused, way too big, and can usually be reduced or replaced with something much more enjoyable to the homeowner.
This sign just slays me. What damage could possibly result from someone using this strip of lawn? And I particularly like the happy face, to add that 'I'm still friendly' vibe. Hmmmm. Maybe the sign is actually a warning to people since the bench and chairs do look a little booby-trapped.
10. And finally…..Know when to cut bait
It can be hard for any of us to know when to quit and start over. I see this time and time again when called by a frustrated homeowner. They've tried and tried and tried to get something to work, sometimes against all odds, sometimes after spending a fortune. I'm all for experimenting in your garden and having fun. But when you find yourself throwing good money after bad it's time to rethink your strategy.
This tree is a great example. I'm not sure at what point things went horribly wrong, but it's okay to say 'You know? I think things could probably be a lot better if I just started over'.
Thanks for stopping by everyone! For more 'reality checks' head on over to my fellow Roundtablers to see what they're writing about. And today we have a very special guest joining us, David Cristiani who blogs at The Desert Edge . Enjoy!
Jocelyn Chilvers : The Art Garden : Denver, CO
Susan Morrison : Blue Planet Garden Blog : Easy Bay, CA
Andrew Keys : Garden Smackdown : Boston, MA
Susan Cohan : Miss Rumphius' Rules : Chatham, NJ
Christina Salwitz : Personal Garden Coach : Renton, WA
Shirley Bovshow : Eden Makers : Los Angeles, CA
Genevieve Schmidt : North Coast Gardening : Arcata, CA

subset: commoncrawl


text:
Netflix Argentina
- Netflix Countries:
- Monster Movies, Action & Adventure, Sci-Fi & Fantasy, Action Sci-Fi & Fantasy, Sci-Fi Adventure, Adventures
- Director(s): Brad Peyton
When a strange chemical mutates three animals into overgrown, aggressive beasts, a primatologist must find an antidote before they destroy the city. They're smashing skyscrapers and wreaking havoc on a city. It's man versus monsters -- and one guy is humanity's only hope.Unable to Watch without Unlocking
Dwayne Johnson, Naomie Harris, Malin Akerman, Jeffrey Dean Morgan, Jake Lacy, Jason Liles, Joe Manganiello, Marley Shelton, P.J. Byrne, Demetrius Grosse, Jack Quaid
Watch "Rampage" on Netflix in Argentina
There is a way to watch Rampage in Argentina, even though it isn't currently available on Netflix locally. What you need is a system that lets you change your Netflix country. With a few simple steps you can be watching Rampage and thousands of other titles!
- Visit Express-VPN.tv in your browser and create an account
- Download and install the free software
- Choose your Netflix country
- Watch "Rampage"!


text:
Credit Unions are Here
Credit Unions are Here
From donating dollars to volunteering hours, Credit Unions across British Columbia are dedicated to making your community better. This interactive website will show you whose doing what and how you can partner with your local credit union (that's us!) to make a lasting difference in your community too
Just visit creditunionsarehelpinghere.com to learn more about the current goals we're working towards and how you can partner with us. Together, we can make a difference.


text:
Why buy from a web-based pharmacy when there are numerous local places to get medication? Are online pharmacies unethical? This article will make an effort to discuss these inquiries and hopefully offer some conclusive answers. Since the beginning of online pharmacies there has been ongoing debate and some action concerning banning the use of online pharmacies altogether in the United States from both people with these and also for the online druggist, by implementing tough fines and punitive measures.
Unfortunately for the on the web pharmacy industry there are many online pharmacies that are total frauds which offers who knows what because medications to make sharp profits for themselves. Generally though there are many genuine online pharmacies that promote the highest quality FDA approved medications, a careful online search done about the pharmacy you are considering purchasing from is an excellent idea so you don't get ripped off. There is a particular usefulness of your online pharmacy that you should considered and looked at before a low cost banning of online pharmacy, either governmentally or professionally. Before making an unfounded decision a person ought to critically examine each party of the arguments associated with both the pros and cons of an online pharmacy.
Some pros of an online pharmacy are the following:
– A person experiencing embarrassing ailments for example erectile dysfunction for example, will get proper drug treatments minus the embarrassment of a community doctor and drugstore visit
– In your extremely busy life-style the ease of buying from a web-based pharmacy is a huge profit in saving time, energy and money, the relative speed and simple ordering needed drugs online are an awesome experience
– Along with the previously mentioned point purchasing medicine online is able to be completed at anytime during the day or perhaps night, 365 days a year, you should buy your medications when you've got time to do so
– If carefully planned, acquiring medications online are the most cost effective ways to purchase medications
– A new shut in or perhaps disabled person demanding medications is able to buy their needed drugs online when it is far too much effort or too costly to make a private visit to a doctor for any prescription
Some cons of an online local pharmacy are the following:
— Government authorities like the FDA have a very difficult time managing and checking up on your amounts of certain restricted medications being sold to individuals
– Government authorities such as the FDA have a very difficult time discovering where an online pharmacy is receiving it's source of medications via and whether or not these sources are genuine
– If the correct research is not done a web based pharmacy could be marketing impure medications or perhaps sawdust packaged like a certain approved treatment and thus ripping away its customers
: An online pharmacy in case left unchecked as well as unrestricted could be transport out medications which can be possibly restricted or even dangerous without a suitable prescription
A person choosing to purchase medication coming from an online pharmacy usually takes several precautions to aid to insure a secure, honest and optimistic experience using an online pharmacy and minimize the risks of ordering through an online pharmacy.
A number of precautions to take will be the following:
– Search on the internet forums and customer review sites talking over the particular online pharmacies you are considering making a purchase via
– One idea safely is obtaining a prescription from your doctor just before ordering from a web based pharmacy, and then you possess some assurance that you are finding the correct medication on your ailment
– Usually examine carefully the privacy policy and the legitimate terms and conditions of the web shop that is selling the medication before buying
– Be positive in which online pharmacy's credit card deals are SSL secured (the actual lock on the bottom in the screen is there when ordering) before ordering
– If the website you are visiting has lots of missing websites, errors, etc. this may be a sign that this website is not the most reliable for ordering medications from
– For those who have a funny unsafe experience when going through the placing your order process from a particular website perhaps decide on another and/or perform some of the above tests on the site
Inspire up to you, the consumer as to if or not you will purchase the medications from a web based pharmacy or purchase your medications from a nearby drug store. Considering every one of the pros and cons a person can quickly make up their minds about which route is the greatest to choose. Remember safeguards always minimize the hazards.


text:
What are duties of the internship for the first semester or term?
- Attend live webinar training one hour per day for five consecutive days.
- Participate in all weekly calls with National Office
- Find a qualified advisor(s)
- Arrange an introductory conference call with my Advisor and the National Office
- Recruit at least 4 additional executive board members
- Register as a student organization and/or seek sponsorship from a campus department
- Arrange a conference call with the National Office, Advisor and the appropriate campus administrator who oversees clubs and/or leadership programs
- Work with my Advisor and the National Office to secure a student list and materials to invite students to participate in the leadership program
- Arrange to have my advisor sign a Memorandum of Understanding with the National Office
"On a campus level, it's a good way to empower and benefit your campus. It helps build leaders. This is a uniform organization where they can all get together and make the campus a better place."
What are duties of the internship for the second semester or term?
- Participate in all weekly calls with National Office
- Host an Executive Board Retreat
- Plan and execute a calendar of events, approved by the National Office.
Note: Campuses with 200+ members must hold more than one option per
event to accommodate students' schedules. NSLS events include:
- Orientation
- Leadership Training Day
- 3 Success Networking Team Meetings
- 3 Speaker Broadcasts
- Induction Ceremony
- Optional events:
- Social event
- Fundraising event
- Community Service event
- Maintain at least 4 additional executive board members throughout the year
- Plan a calendar of events for the next term, approved by the National Office


text:
What's that thing about waiting for a bus? You wait ages and then along comes....
It's been kind of like that for music on TV. Just when you thought production companies and TV commissioners had given up on pop, a raft of new music offerings suddenly rock up.
One of the newest is the channel launch from All Around The World's TV division, Planet Pop, which hits the Sky and Freesat platforms this morning.
Less enduring perhaps than a specialist music channel, but no less welcome has been the number of music series that have cropped up lately.
Just last month Globe Productions, which has produced a raft of music shows including Paul Weller Into Tomorrow for BBC2 and this weekend dishes up the TV premiere of Girls Aloud: 10 The Hits Tour, ran its second series of Launched At Red Bull Studios on Channel 4.
Presented by Annie Mac with established acts and tastemakers mentoring their top tips - Ladyhawke championing Willy Moon; The Cribs' Gary Jarman supporting The Cheatahs - the 10 shows featured the hottest new bands to make waves this year. This is music discovery at its purest.
Then as Launched At Red Bull hit its stride, BBC4 lined up a bunch of middle aged blokes to wax lyrical about prog rock and the required etiquette for listening to The Clash's debut album.
Danny Baker's Great Albums Showdown veered close to eclipsing the levels of overwrought reverence only fans of Yes can muster. But, it was good, old fashioned, watchable TV. In fact well over 1m viewers - not huge by X-Factor standards, but still respectable - tuned in over three consecutive nights.
BBC4 Danny Baker's Great Albums Showdown
February 5: 467,300 viewers - 2.0% audience share
February 6: 340,400 viewers - 1.3% audience share
February 7: 304,700 - 1.3% audience share
Total - 1,112,400
(source: BBC)
And that's not all. Channel 4 is gearing up to launch a major new late night music series later this year.
The new Channel 4 show may even herald music's return as the key ingredient to kickstart the weekend; the broadcaster has specified a format that is suitable for an hour long Friday night slot at 11pm - just when the pubs begin to empty.
Production companies are currently working up their pitches and it is expected that three shows will be piloted with one chosen to become the series. That is expected to run for up to 16 weeks, starting in late summer.
These developments appear to signpost that music TV is in rude health. That hasn't been the case of late. Unlike cookery and property renovation, music recently hasn't had the breaks with primetime TV slots.
Part of the problem is that making pop work on TV is hard. There's fierce competition to capture the attention of easily bored 16-24 year olds, especially on the Sky platform where Planet Pop will be competing against at least half a dozen established pop channels such as MTV Hits and Smash Hits in addition to more genre specific shows, including those from its own AATW stable, including Channel AKA, Greatest Hits and Clubland.
And that ignores the two dedicated music channels on Freeview, 4 Music and Viva, and the rest of the distractions in a youngster's life. It's a remote flicking culture and nothing gets flicked off the screen quicker than a grime video by a sulky teenager in Leeds who is into The Strypes or gets bored and digs out the Sony Playstation.
Plus, music TV is often not the primary viewing destination. It is background viewing. In fact, much of it is watched (through the corner of their eye) by students doing their homework or if there is nothing else on the box; unless its Friday or Saturday night when people need a few tunes in the background while they prepare to party.
TV commissioning editors have been resistant to new music series because they seem to think music is already well served by entertainment and talk shows such as the X Factor, The Voice, returning this weekend and Jonathan Ross.
They would also argue that coverage of music festivals, like Glastonbury, one-off documentaries featuring acts such as Take That, and music awards such as The Brits, broadcast live on ITV later this month, and the Barclaycard Mercury Prize, has not been higher.
But, much of this is "event" TV or mass entertainment market shows, which tend to focus on bigger, established acts who can bring with them a ready made audience of fans.
Arguably, the only place nowadays to discover newish bands on mainstream telly is on the one remaining "pure music" show, Later...with Jools Holland.
Of course there is the web. And some music content has successfully moved online where it is a big hit with a new generation of viewers, who never saw Tony Blackburn strutting his stuff on TOTP and are unwilling to wait a week to check out what is hot in the charts.
Online is where a lot of musical discovery - and decent-sized audiences - have migrated to as evidenced by an October 2011 Elbow gig in Manchester Cathedral. No fewer than 920,000 viewers headed to the Radio 2 website to watch that online.
These and other online viewers can search Bebo, Vevo or YouTube and watch niche or specialist videos, documentaries and shows dedicated to hip hop all day long. This is where Iain Funnell, general manager at Universal Music's in-house production company Globe Productions, and others believe music programming and music discovery can flourish in the future.
Already Funnell's company has dipped its toe into this area. The Secret World Of Sam King, a fictional character who supposedly worked in the post room of Universal Music, had his adventures - bumping into the Pussycat Dolls in the company's lift and having The Saturdays play tricks on him - uploaded each day on to Bebo.
Of course, a lot of people don't have the time, energy or inclination to hunt around online for programmes about the edgy women pioneers of punk or the roots of hip hop in 80s New York. A massive audience still want all kinds of music thrust in to their lives in well curated, easily digestable, ways.
That means the box in the corner of the living room. And commissioners and production companies seem to have suddenly realised there are some real advantages in producing music TV. For starters, it needn't be expensive. Planet Pop and its three sister channels, for example, can be programmed and run by just four people.
The arrival of new technology means new programmes can also borrow wholesale from the online environment and include the most successful interactive elements such as social networking, which young viewers now demand as standard.
"It's almost got to the point where you can watch TV your way and I think that side of technology is very exciting," adds Funnell. "If you only have 30 seconds of Pete Townshend playing a song on TV then you can watch the whole thing online."
Soon viewers will not only be able to choose the camera angles, but they will also be able to play along with the band. They could never do that with The Old Grey Whistle Test.


text:
We Love First Time Riders!
Need a Bike?
Bike and Roll offers four locations in and around Washington DC – National Mall at L'Enfant Plaza, Union Station, the National Museum of American History, and on the Mount Vernon Trail in Alexandria.
Or pick up a bike at one of the hundreds of Capital Bikeshare stations in the District, Arlington, Alexandria, Montgomery County, and Fairfax County.
Welcome to this Fun Event! Participating in the Bike to Work Day event for the first time is a very exciting experience, but if you've never commuted by bicycle before you may be a bit apprehensive about it. No worries, we're here to help and there will be over a thousand of commuters participating for the first time this year just like you. We want to do everything we can to make this an easy and positive experience for you. Find a bike riding buddy, join a commuter bicycling convoy or just go it alone, what ever makes you more comfortable. Learn some bike basics by taking a class and/or by reading up on bicycling tips. So c'mon, we know you're ready for the challenge, and you'll be proud of yourself for doing it! Click on the links for some helpful information to get you started.


text:
December 31, 2021 @ 9:50 am - 1:15 pm
Belgrave Station is the headquarters of the railway and only a short walk from the Belgrave Township which has an abundance of shopping and dining options.
Belgrave Station is easily accessible by car or by fast electric train from Melbourne, approximately a 70-minute journey. For more information, click HERE.
Belgrave depart – 10.30 am
Menzies Creek arrival – 10.53 am
Menzies Creek depart – 11.05 am
Emerald depart – 11.20 am
Lakeside arrival – 11.30 am
Return from Lakeside at:
45-minute layover at Lakeside Station:
Lakeside depart – 12.15 pm
Emerald depart – 12:25 pm
Menzies Creek arrival – 12.43 pm
Menzies Creek depart – 12.50 pm
Belgrave arrival – 1.15 pm
The ticket entitles the traveller to return to the station of departure on any of Puffing Billy's scheduled services that day.
Please enjoy your time with us.


text:
Founded in 1967, the San Antonio Spurs are a National Basketball Association (NBA) team known for their consistency year after year. Being the only professional sports team in San Antonio, Texas, the Spurs have a special connection with their fan base and looked for an advertising solution that could reach fans specifically looking for single game tickets, value-night tickets or resale tickets, at scale.
Quantcast has delivered significant value for us. Not only does their insight into the entire Internet audience drive great results for our digital campaigns, but it has also informed our media spend in other marketing channels."
The Spurs chose Quantcast's Complete Targeting solution to efficiently grow their ticket sales by identifying high-potential prospects similar to the Spurs' current fan base.
- Efficient Prospecting: Quantcast minimized wasted impressions by targeting people who most closely matched the online behaviors and patterns of the Spurs' existing online ticket purchasers.
- Smart Retargeting: Quantcast kept the Spurs top of mind with potential ticket purchasers by identifying and converting the Spurs' highest-value website visitors.
- Audience Insights: With Quantcast-provided data, the Spurs learned that their fans were most likely to make ticket purchases on Friday afternoons. This information helped to inform advertising messaging and to manage daypart targeting for other channels, such as television.
The Quantcast campaign delivered:
- 850% ROAS, beating the campaign goal by 3X.
- Ticket buyers prospected by Quantcast converted 5X more than the site average.
- Insights into purchasers' media behavior helped inform a more efficient and effective media mix.


text:
Abacavir is an FDA-approved drug used to treat HIV-1 infection in conjunction with other antiretrovirals. Like other nucleoside reverse-transcriptase inhibitors (NRTIs), abacavir use is typically in combination with other HIV medications. Abacavir is not recommended for use by itself.[1] It can be taken by mouth as a tablet or solution and may is a treatment option in patients over the age of three months.[2] Commonly, abacavir is dispensed together with other HIV medications such as abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, and abacavir/lamivudine.[3]
Abacavir is a nucleoside reverse transcriptase inhibitor. Within this class, it is specifically a carbocyclic 2'-deoxyguanosine, also known as a guanosine analog. After oral ingestion, abacavir sulfate is rapidly absorbed and reaches peak concentrations at about 0.63 to 1 hour with an absolute bioavailability of about 83%. Abacavir displays linear pharmacokinetics and possesses dose proportionality over the range of 300 to 1200 mg/day. Taking abacavir with food has not had any clinically relevant effect on exposure to the drug and can be safely ingested in the presence or absence of food. The volume of administration by parental route is about 0.86 +/- 0.15 L/kg. Plasma protein binding is about 50% and has an independent relationship with the plasma concentration of the drug.
The liver accomplishes the majority of abacavir's metabolism. The remaining bioavailable 2% of the compound gets excreted as an unaltered product in the urine. Two major metabolic pathways are known as the uridine diphosphate glucuronyltransferase, and the alcohol dehydrogenase pathway processes abacavir within the liver. Enzymatic metabolism produces an inactive glucuronide metabolite (361W94, approximately 36% of the dose recovered in the urine) and an additional inactive carboxylate metabolite (2269W93, about 30% of the dose recovered in the urine) — the other 15% of the compound ends up in the urine as minor metabolites, which comprise less than 2% of the orally ingested amount. Elimination through stool makes up about 16% of the original dose. CYP450 metabolism of abacavir does not play a substantial role in abacavir, and no observable drug interactions that alter clinical decision making exist within recommended doses of methadone, or alcohol, zidovudine, abacavir, and lamivudine.[4]
The antiviral effect of abacavir is due to its intracellular anabolite, carbovir-triphosphate, which interferes with HIV viral RNA-dependent DNA polymerase, leading to inhibition of viral replication.[5] This intracellular anabolite has shown to have a long elimination half-life of greater than 20 hours, allowing for once-daily dosing.[4]
Abacavir is administered as 300 mg twice daily or as 600 mg once daily. It is also available as part of several co-formulated tablets. These different co-formulations are part of nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs).[6]
There are no dosage adjustments recommended in patients with renal impairment, and abacavir is well-tolerated in patients that would benefit from NRTI use with renal pathology from other antiretrovirals.[7] The recommendation is to dose-adjust in hepatic impairment. Mild hepatic impairment denoted as Child-Pugh class A is suggested at 200 mg twice daily as an oral solution. Contraindications to abacavir include moderate to severe hepatic impairment, Child-Pugh class B or C, due to lack of evidence.[4]
The common toxicities of the NRTI class are mitochondrial toxicity, which can present as hepatic steatosis, lipoatrophy, pancreatitis, and peripheral neuropathy.[8] Symptomatic lactic acidosis can also occur in patients, and these require monitoring due to an increased risk of mortality.[9] Additionally, patients on long-term antiretroviral therapy (ART) may experience fat redistribution: lipodystrophy.[10]
Clinicians should avoid abacavir should in people with coronary artery disease and those at increased risk of myocardial infarction due to an increased risk of hyperlipidemia and cardiovascular events.[11][12][13]
Contraindications to the use of abacavir in ART therapy include hypersensitivity to abacavir or any formulation component, moderate to severe hepatic impairment, and patients who are positive for the HLA-B*5701 allele.[14] Also, in patients with moderate to severe hepatic impairment, Child-Pugh class B or C, abacavir administration is relatively contraindicated due to lack of study.[4]
Abacavir should also be avoided in patients and is relatively contraindicated in individuals who test positive for HLA-DR7 and HLA-DQ3 alleles because evidence shows that withholding abacavir leads to a reduced incidence of hypersensitivity reactions.[15]
There is some potential for drug-induced injury to the body that requires monitoring when administering abacavir to patients with HIV. Patients should receive screening for HLA-B*57101 genotype status before the start of therapy and before a continuation of therapy in patients with unknown HLA*B57101 status. Patients should have CBC with differential, serum creatinine kinase, CD4 count, HIV RNA plasma level, triglycerides, and serum amylases monitored periodically.[14] Clinicians should be aware of the risk for acute and late-onset hepatotoxicity and monitor AST and ALT levels.[16] Signs of central fat gain or lipoatrophy should be assessed for fat gain or fat loss to fine-tune ART therapy.[17]
Serious and sometimes fatal hypersensitivity reactions can potentially occur with abacavir. Patients who possess the HLA-B*5701 allele also carry a higher risk for a hypersensitivity reaction to abacavir; however, hypersensitivity reactions have occurred in those who do not carry the HLA-B*5701 allele. All patients should receive screening for the HLA-B*5701 allele.[14]
Managing the administration of abacavir to HIV patients requires an interprofessional team of healthcare professionals that includes a nurse, laboratory technologists, pharmacists, social workers, and several physicians in different specialties. After HIV diagnosis, prompt admission into HIV medical and adherence/retention in that care is fundamental to the administration of effective antiretroviral therapy. Adherence to ART is one of the top factors of favorable HIV treatment outcomes and is necessary to decrease the occurrence of drug resistance within the patient. Common obstacles to successful ART stem from an absence of social support and alcohol or substance abuse, which prevent patients from having sustained therapy.
The emphasis on adherence cannot be overemphasized. Clinicians, specialists, nurses, and pharmacists all must share in the effort to educate the patient and monitor adherence. For example, if the patient is chronically late in picking up their prescription, meaning there will be days without therapy, the pharmacist must call the physician's office and share this information with the nurse or prescriber. The pharmacist is also responsible for medication reconciliation and verifying dosing parameters. On follow-up visits, the nurse must verify compliance and should do so by asking open-ended questions that force the patient to reveal familiarity with their regimen. Failure to take the drugs in ART correctly can result in therapeutic failure for the entire drug class, as the virus can obtain adaptive immunity; this is why any type of ART absolutely requires open, interprofessional team communication to ensure the best chance for therapeutic success. [Level 5]
Recommendations for increasing successful outcomes in antiretroviral therapy
|Park MS,Yang YM,Kim JS,Choi EJ, Comparative study of antiretroviral drug regimens and drug-drug interactions between younger and older HIV-infected patients at a tertiary care teaching hospital in South Korea. Therapeutics and clinical risk management. 2018 [PubMed PMID: 30519031]
|Katlama C,Ingrand D,Loveday C,Clumeck N,Mallolas J,Staszewski S,Johnson M,Hill AM,Pearce G,McDade H, Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group. JAMA. 1996 Jul 10 [PubMed PMID: 8656503]
|Greig SL,Deeks ED, Abacavir/dolutegravir/lamivudine single-tablet regimen: a review of its use in HIV-1 infection. Drugs. 2015 Apr [PubMed PMID: 25698454]
|Yuen GJ,Weller S,Pakes GE, A review of the pharmacokinetics of abacavir. Clinical pharmacokinetics. 2008 [PubMed PMID: 18479171]
|Anderson PL,Kakuda TN,Kawle S,Fletcher CV, Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. AIDS (London, England). 2003 Oct 17 [PubMed PMID: 14523272]
|Saag MS,Benson CA,Gandhi RT,Hoy JF,Landovitz RJ,Mugavero MJ,Sax PE,Smith DM,Thompson MA,Buchbinder SP,Del Rio C,Eron JJ Jr,Fätkenheuer G,Günthard HF,Molina JM,Jacobsen DM,Volberding PA, Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2018 Jul 24 [PubMed PMID: 30043070]
|Postorino MC,Quiros-Roldan E,Maggiolo F,Di Giambenedetto S,Ladisa N,Lapadula G,Lorenzotti S,Sighinolfi L,Castelnuovo F,Di Pietro M,Gotti D,Mazzini N,Torti C, Exploratory Analysis for the Evaluation of Estimated Glomerular Filtration Rate, Cholesterol and Triglycerides after Switching from Tenofovir/Emtricitabine plus Atazanavir/Ritonavir (ATV/r) to Abacavir/Lamivudine plus ATV/r in Patients with Preserved Renal Function. The open AIDS journal. 2016 [PubMed PMID: 27563366]
|Boubaker K,Flepp M,Sudre P,Furrer H,Haensel A,Hirschel B,Boggian K,Chave JP,Bernasconi E,Egger M,Opravil M,Rickenbach M,Francioli P,Telenti A, Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2001 Dec 1 [PubMed PMID: 11692306]
|Coghlan ME,Sommadossi JP,Jhala NC,Many WJ,Saag MS,Johnson VA, Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2001 Dec 1 [PubMed PMID: 11692304]
|Carr A, HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS (London, England). 2003 Apr [PubMed PMID: 12870540]
|Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. AIDS (London, England). 2008 Sep 12 [PubMed PMID: 18753925]
|Sabin CA,Worm SW,Weber R,Reiss P,El-Sadr W,Dabis F,De Wit S,Law M,D'Arminio Monforte A,Friis-Møller N,Kirk O,Pradier C,Weller I,Phillips AN,Lundgren JD, Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet (London, England). 2008 Apr 26 [PubMed PMID: 18387667]
|Marcus JL,Neugebauer RS,Leyden WA,Chao CR,Xu L,Quesenberry CP Jr,Klein DB,Towner WJ,Horberg MA,Silverberg MJ, Use of Abacavir and Risk of Cardiovascular Disease Among HIV-Infected Individuals. Journal of acquired immune deficiency syndromes (1999). 2016 Apr 1 [PubMed PMID: 26536316]
|Lucas A,Nolan D,Mallal S, HLA-B*5701 screening for susceptibility to abacavir hypersensitivity. The Journal of antimicrobial chemotherapy. 2007 Apr [PubMed PMID: 17317695]
|Mallal S,Nolan D,Witt C,Masel G,Martin AM,Moore C,Sayer D,Castley A,Mamotte C,Maxwell D,James I,Christiansen FT, Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet (London, England). 2002 Mar 2 [PubMed PMID: 11888582]
|Christensen ES,Jain R,Roxby AC, Abacavir/Dolutegravir/Lamivudine (Triumeq)-Induced Liver Toxicity in a Human Immunodeficiency Virus-Infected Patient. Open forum infectious diseases. 2017 Summer [PubMed PMID: 28748198]
|de Waal R,Cohen K,Maartens G, Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction. PloS one. 2013 [PubMed PMID: 23723990]
|Harrigan PR,Hogg RS,Dong WW,Yip B,Wynhoven B,Woodward J,Brumme CJ,Brumme ZL,Mo T,Alexander CS,Montaner JS, Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. The Journal of infectious diseases. 2005 Feb 1 [PubMed PMID: 15633092]
|Cohen MS,Chen YQ,McCauley M,Gamble T,Hosseinipour MC,Kumarasamy N,Hakim JG,Kumwenda J,Grinsztejn B,Pilotto JH,Godbole SV,Mehendale S,Chariyalertsak S,Santos BR,Mayer KH,Hoffman IF,Eshleman SH,Piwowar-Manning E,Wang L,Makhema J,Mills LA,de Bruyn G,Sanne I,Eron J,Gallant J,Havlir D,Swindells S,Ribaudo H,Elharrar V,Burns D,Taha TE,Nielsen-Saines K,Celentano D,Essex M,Fleming TR, Prevention of HIV-1 infection with early antiretroviral therapy. The New England journal of medicine. 2011 Aug 11 [PubMed PMID: 21767103]
|Metsch LR,Pereyra M,Messinger S,Del Rio C,Strathdee SA,Anderson-Mahoney P,Rudy E,Marks G,Gardner L, HIV transmission risk behaviors among HIV-infected persons who are successfully linked to care. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2008 Aug 15 [PubMed PMID: 18624629]
|Tripathi A,Youmans E,Gibson JJ,Duffus WA, The impact of retention in early HIV medical care on viro-immunological parameters and survival: a statewide study. AIDS research and human retroviruses. 2011 Jul [PubMed PMID: 21142607]
|Gardner LI,Metsch LR,Anderson-Mahoney P,Loughlin AM,del Rio C,Strathdee S,Sansom SL,Siegal HA,Greenberg AE,Holmberg SD, Efficacy of a brief case management intervention to link recently diagnosed HIV-infected persons to care. AIDS (London, England). 2005 Mar 4 [PubMed PMID: 15750396]
|Deschamps AE,De Geest S,Vandamme AM,Bobbaers H,Peetermans WE,Van Wijngaerden E, Diagnostic value of different adherence measures using electronic monitoring and virologic failure as reference standards. AIDS patient care and STDs. 2008 Sep [PubMed PMID: 18754705]
|Molina JM,Podsadecki TJ,Johnson MA,Wilkin A,Domingo P,Myers R,Hairrell JM,Rode RA,King MS,Hanna GJ, A lopinavir/ritonavir-based once-daily regimen results in better compliance and is non-inferior to a twice-daily regimen through 96 weeks. AIDS research and human retroviruses. 2007 Dec [PubMed PMID: 18160008]
|Boyle BA,Jayaweera D,Witt MD,Grimm K,Maa JF,Seekins DW, Randomization to once-daily stavudine extended release/lamivudine/efavirenz versus a more frequent regimen improves adherence while maintaining viral suppression. HIV clinical trials. 2008 May-Jun [PubMed PMID: 18547903]
|Dejesus E,Young B,Morales-Ramirez JO,Sloan L,Ward DJ,Flaherty JF,Ebrahimi R,Maa JF,Reilly K,Ecker J,McColl D,Seekins D,Farajallah A, Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients. Journal of acquired immune deficiency syndromes (1999). 2009 Jun 1 [PubMed PMID: 19357529]
|Lester RT,Ritvo P,Mills EJ,Kariri A,Karanja S,Chung MH,Jack W,Habyarimana J,Sadatsafavi M,Najafzadeh M,Marra CA,Estambale B,Ngugi E,Ball TB,Thabane L,Gelmon LJ,Kimani J,Ackers M,Plummer FA, Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet (London, England). 2010 Nov 27 [PubMed PMID: 21071074]
|Mannheimer SB,Morse E,Matts JP,Andrews L,Child C,Schmetter B,Friedland GH, Sustained benefit from a long-term antiretroviral adherence intervention. Results of a large randomized clinical trial. Journal of acquired immune deficiency syndromes (1999). 2006 Dec 1 [PubMed PMID: 17091022]
|de Bruin M,Hospers HJ,van Breukelen GJ,Kok G,Koevoets WM,Prins JM, Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. 2010 Jul [PubMed PMID: 20658830]
|Sabin LL,DeSilva MB,Hamer DH,Xu K,Zhang J,Li T,Wilson IB,Gill CJ, Using electronic drug monitor feedback to improve adherence to antiretroviral therapy among HIV-positive patients in China. AIDS and behavior. 2010 Jun [PubMed PMID: 19771504]
|Altice FL,Maru DS,Bruce RD,Springer SA,Friedland GH, Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 Sep 15 [PubMed PMID: 17712763]
|Macalino GE,Hogan JW,Mitty JA,Bazerman LB,Delong AK,Loewenthal H,Caliendo AM,Flanigan TP, A randomized clinical trial of community-based directly observed therapy as an adherence intervention for HAART among substance users. AIDS (London, England). 2007 Jul 11 [PubMed PMID: 17589194]
|Maru DS,Bruce RD,Walton M,Springer SA,Altice FL, Persistence of virological benefits following directly administered antiretroviral therapy among drug users: results from a randomized controlled trial. Journal of acquired immune deficiency syndromes (1999). 2009 Feb 1 [PubMed PMID: 19131891]
|Safren SA,O'Cleirigh C,Tan JY,Raminani SR,Reilly LC,Otto MW,Mayer KH, A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. 2009 Jan [PubMed PMID: 19210012]


text:
|U.S. Representative Grace Napolitano Discusses Issues Facing Centric Parts
On June 8, 2011, Centric Parts was honored to welcome Congresswoman Grace Napolitano and her staff to our City of Industry facility for a Congressional visit. Rep. Napolitano (D-CA) is serving her 7th term as the U.S. Representative for California's 38th Congressional District, which includes City of Industry, Pomona, Norwalk and other parts of East Los Angeles County.
While visiting our offices the Congresswoman met with Centric Parts President, Dan Lelchuk, CFO Estelle Cohen and Director of Integrated Supply Chain Steve Hughes, who were grateful for the Representative's time and insight.
|The Centric Team with Rep. Napolitano
The Congresswoman met with our group to learn more about what Centric Parts does and to find out how she can better serve us as one of her larger constituents.
"What can I do for you? How can I better serve you and represent you in Congress," the Representative asked. While jokingly declining an offer to make some parts deliveries to our customers, the Congresswoman was very helpful in several other ways. "I was with Ford Motor Company for 30 years in part inventory control, so I understand about the auto industry and the parts business."
"We were able to talk to the Congresswoman about some of the legislation that is affecting the aftermarket. With her prior industry experience and long political career, she was extremely helpful in finding solutions," said Estelle Cohen.
One of the bills discussed was CA SB750, which limits the ability of independent key providers to issue replacement keys for BMW vehicles. "The impact of Legislation like CA SB 750 will cost the aftermarket money and jobs," explained Steve Hughes.
When Representative Napolitano asked for further evidence as to how this issue would impact consumers and small business owners, Hughes gave the following example, which seemed to resonate with the Congresswoman: "Imagine you are out in the middle of nowhere and you lose or damage your ignition key. If they don't allow independent shops to cut those keys, you would be forced to go to the closest BMW dealer for a replacement. In some rural areas it is entirely possible that you wouldn't be able to find a dealer nearby, so you'd likely be stuck waiting for a FedEx shipment the next couple of days."
The group also discussed ongoing intellectual property (IP) issues - and patents in particular - that threaten our competitive advantage in overseas markets, a bearing Anti-Dumping Duty (ADD) that is unfairly being applied to a whole wheel hub assembly, and Right to Repair, which aims to protect consumers from a monopoly on car repairs while protecting the viability of independent repair shops.
"Right to Repair is the name given to legislation designed to allow small repair shops access to complex systems information from the original equipment manufacturers. With cars getting more complex every year, smaller repair shops increasingly lack the data and proprietary tools necessary to perform repairs themselves," explained Steve Hughes. "The number of computers and computer controlled functions on new cars is staggering."
"Right now, there is no legislation preventing original equipment manufacturers from limiting access to computer codes and other data that independent repair shops need in order to perform adequate repairs on vehicles," explained Centric President Dan Lelchuk. "If they chose to do so, and they have on numerous occasions already, the OEMs could keep that information private, forcing consumers to have their repairs done at the dealership. Not only would consumers likely have to pay higher repair bills due to a lack of competition, but it could easily drive independent repair shops out of business altogether."
Lelchuk continued, "We strongly believe that consumers should have the right to get their personal property serviced where they choose. That's why the U.S. needs to pass a Right to Repair bill like House Bill HR1449, recently introduced by Congressman Edolphus Townes of New York. The Right to Repair Act has been around for a decade in one form or another, but we haven't been able to get Congress to move on it. This is a critical issue for our industry that needs to be dealt with."
While promising to further review these issues, the Congresswoman also recommended individuals in the private and public sector who may be of further assistance at the local, state and national levels. Rep. Napolitano supplied names and numbers and even a few on-the-spot connections with some of her many contacts.
It was a very productive meeting that resulted in several specific suggestions that will better help Centric meet its current and future goals. In fact, Hughes and Cohen have already been in contact with Napolitano's Legislative Director in Washington, Joe Sheehy, regarding possible resolutions to some of these issues. Centric looks forward to working with the Representative and her staff even more in the future.


text:
Please visit a blog we created for TonyBoy and feel free to forward this information on!!!
This is my Sister In Law's nephew.
This is my Sister In Law's nephew.
On June 19th, 2009, Tonyboy was excited to be celebrating his 13th birthday when tragedy occurred. During a visit to a friend's house, he was "accidentally" shot in the head, changing his life forever. Since the shooting, Tonyboy has been in a coma, fighting for his young life. If you know Tonyboy, you know that he has a beautiful, infectious smile that can light up a room. Tonyboy has such an incredible love for fishing & camping that you can't help but smile while watching him.
With your thoughts, prayers & warm wishes, Tonyboy continues to get better everyday. His will to Live & Courage to keep fighting gives us all strength. Although we know that times are tough, we are reaching out to the community to help ensure that he is able to get the proper rehabilitation & medical attention that will be necessary for his recovery.
On behalf of Tonyboy & his family, we thank you from the bottom of our hearts!


text:
Authors : Manning Jeane - Begich Nick
Title : Angels don't play this HAARP
Year : 1997
Link download : Manning_Jeane_-_Begich_Nick_-_Angels_don_t_play_this_HAARP.zip
Environmental Warfare? The U. S. Government has a new ground-based "Star Wars" weapon which is being tested in the remote bush country of Alaska. This new system manipulates the environment in a way which can: • Disrupt human mental processes. • Jam all global communications systems. • Change weather patterns over large areas. • Interfere with wildlife migration patterns. • Negatively affect your health. • Unnaturally impact the Earth's upper atmosphere. The U.S. military calls its zapper HAARP (High-frequency Active Auroral Research Project). But this skybuster is not about the Northern Lights. This device will turn on lights never intended to be artificially manipulated. Their first target is the electrojet - a river of electricity that flows thousands of miles through the sky and down into the polar icecap. The electrqjet will become a vibrating artificial antenna for sending electromagnetic radiation raining down on the earth. The U.S. military can then "X-ray" the earth and talk to submarines. But there's much more they can do with HAARP. This book reveals surprises from secret meetings. PROJECT CENSORED - a prestigious panel of journalists - judged HAARP to be in the top ten under-reported news stories of 1994. POPULAR SCIENCE - As a front-cover story, HAARP began to be revealed in September, 1995. This book is - the rest of the story. The High-frequency Active Auroral Research Project is The HAARP that Angels Don't Play. About the Authors. Dr. Nick Begich is the eldest son of the late United States Congressman from Alaska, Nick Begich Sr., and political activist Pegge Begich. He is well known in Alaska for his own political activities. He was twice elected President of both the Alaska Federation of Teachers and the Anchorage Council of Education. He has been pursuing independent research in the sciences and politics for most of his adult life. Begich received his doctorate in traditional medicine from The Open International University for Complementary Medicines in November, 1994. He co-authored the book Earth Rising - The Revolution: Toward a Thousand Years of Peace with James Roderick in January 2000. He is also the editor of Earthpulse Flashpoints, a new-science book series. Begich has published articles in science, politics and education and is a well known lecturer, having presented throughout the United States and in nineteen countries. He has been featured as a guest on thousands of radio broadcasts, reporting on his research activities including new technologies, health and earth science related issues. He has also appeared on dozens of television documentaries and other programs throughout the world including BBC-TV, CBC-TV, TeleMundo, and others. Begich has served as an expert witness and speaker before the European Parliament. He has spoken on various issues for groups representing citizen concerns, statesmen and elected officials, scientists and others. He is the publisher and coowner of Earthpulse Press and is also under contract as Tribal Planner for the Chickaloon Village Council, a federally recognized American Indian Tribe of the Athabascan Indian Nation. Dr. Begich is married to Shelah Begich- Slade and has five children. He resides just north of Anchorage in the community of Eagle River, Alaska, USA. Jeane Manning is an experienced magazine journalist, reporter for daily newspapers and former editor of a community newspaper. A decade of researching nonconventional electrical energy technologies culminated in her book The Coming Energy Revolution (Avery Publishing Group, NY, 1996). She is co-author of a 1994 book published by Auckland Institute of Technology Press, New Zealand, Suppressed Inventions and other Discoveries. Born in Cordova, Alaska, she tracked HAARP with deep interest. She now lives in Vancouver, Canada. ...
Support Balder Ex-Libris ! Knowledge is not free
We share books for free, but maintaining such a site online requires costly hosting. You can...


text:
Don't drop this cam
There are a lot of "baby cams" on the market, offering many ways to keep watch over your child when you are out of the room. One great choice was first designed as a general-purpose surveillance camera, not a parental device — and so it may deliver more features at a less boutique-y price.
The Dropcam is a $150 HD-resolution camera that sends a WiFi signal you can see and hear on your smartphone, or over the Web on a computer.
(Affiliate link.)


text: I have a P2P bridge setup with two 7731s. Everything has been working well for some time but just recently we have had issues with IP phones crackling and dropping over the connection. I did a channel optimizer and the signal shows stronger than previous and is on a different channel. The ruckus speed test shows about 60/60 with 0 packet loss. When I run a speed test from the remote site I only get about 20/20. On the primary site I am getting 90/90. Is there that much overhead that would cause me to drop that much?


text:
170 past events Cuneo | 40539 past events Italy
Past events Cuneo
Monday 26 October 2020
Category: Sport
Time: On 22/03/2009
An event marked by sport and fun. The non-competitive race, open to everyone, is held in many Italian city and its course goes around the city's streets.
Where: Via Peano-Via Roata Canale
Info: +39.0171.346491
E-mail: firstname.lastname@example.com
Web-site: www.aicscuneo.it
From Rubens to Van Dyck
Category: Art exhibitions
Time: From 18/12/2009 to 28/02/2010
The exhibition traces painting in North Europe between 15th century and 18th century through a selection of 60 paintings coming from private and public collections. On display works by Rubens, Van Dyck, Joahnn Liss, Adriaen van Ostade, Jan Brueghel II the Young, Jan Haviscksz Steen and others
Where: Palazzo Samone
Address: Via Amedeo Rossi 4 - 12100 Cuneo
Web-site: www.comune.cuneo.it/cultura/avvenimenti/
Tour of Italy
Category: Sport
Time: On 12/05/2010
The tour of Italy reaches its 4th stage. The cyclists start from Cuneo and a route of 250 km leads them to Pinerolo, where the stage ends.
Where: Cuneo
Web-site: www.gazzetta.it
Super Randonnée
Category: Sport
Time: On 02/07/2010
Cyclists compete along 400km route that winds through Cuneo and the surroundings in 44 hours.
Info: +39.0171.690269
E-mail: email@example.com
Web-site: www.faustocoppi.net
Closed doors, light on culture
Category: Shows
Time: On 12/11/2010
Italian culture on strike on 12th November. Museums, libraries, archeological sites and other places could be closed. For further information contact the properties you want to visit to verify if it is open.
Where: Various locations
Paolo Bedino: tutta la mia citta'
Category: Art exhibitions
Time: From 20/11/2010 to 30/01/2011
Pictures by Paolo Bedino illustrates the city of Cuneo between 1963 and 1973.
Where: Palazzo Samone
Info: +39.0171.4441
Address: Via Amedeo Rossi 4 - 12100 Cuneo
Category: Art exhibitions
Time: From 14/12/2010 to 21/12/2010
Photographic exhibition by the artist Maurizio Milanesio.
Free entry
Where: Corso Nizza angolo Corso Dante
info +39.0171.445886
E-mail: firstname.lastname@example.com
La donna immaginata. L'immagine di donna
Category: Art exhibitions
Time: From 22/06/2011 to 03/07/2011
The exhibition presents 180 vintage cartoons dealing with women, published in Italian newspapers and magazines from 1850 to the present day.
Where: Museo Casa Galimberti
Web-site: www.comune.cuneo.gov.it/news/dettaglio/p
Granfondo Fausto Coppi - Selle San Marco
Category: Sport
Time: On 03/07/2011
Cyclists compete along a 141km or 111km route that winds through the province Cuneo.
Where: Start and finish Piazza Galimberti
Info: +39.0171.690269
E-mail: email@example.com
Web-site: www.faustocoppi.net
Fausto Coppi Mangia Pedala
Category: Sport
Time: On 03/07/2011
Fausto Coppi Mangia Pedala combines sport with food & wine products. It is a 50 km bike ride, open to everyone. Participants can taste typical products and discover the beautiful countryside and nature around Cuneo.
Where: Start from Piazza Galimberti
E-mail: email@example.com
Web-site: www.faustocoppi.net


text:
Backyard barbecues can be a fun and relaxing way to take advantage of summer weather and time for recreation. Party games can keep everyone active and interacting while the food is cooked. BBQ games can also engage a variety of ages, making them perfect for family get-togethers. Just keep some towels and cleansing wipes nearby, so everyone can stay outside and eat immediately after playing.
Water Balloon Toss
Beat the heat and stay active with a water balloon toss, suggests social event planning site Evite.com. Throwing water balloons between individuals or at specific targets that are far away from onlookers can keep everyone entertained and cool, ensuring happy distraction until the last burger is grilled. Just filling the water balloons can keep children entertained.
Lay an Egg
Pair up and try to tote a raw egg to work on coordination skills. A variation on an egg relay race, this game can engage older children and adults. Each pair of people must stand back-to-back, nestling a raw egg between their backs. They must lower the egg to the ground without it breaking. The first couple to lay the egg, with no visible cracks, wins.
Pass the Sand
Pass around a fistful of sand for an interesting challenge. Fill a small container with sand and form two teams, each positioned in a line. The first player on each team grabs a handful of sand, then passes it on down the line. The last player empties the remaining fistful of sand on a plate. Whichever team has the most sand left over, wins. Close calls may require a food scale.
Obstacle Course
Turn lawn furniture into an obstacle course, recommends AmazingMoms.com. Combine exercise and play by encouraging specific movements, such as hopping along a winding garden hose. Kids can crawl under lawn chairs or tote a ball between their knees as they try to cross the lawn. Obstacle courses can then be adapted for a game of "Simon Says."
Photo Credits
- Digital Vision./Photodisc/Getty Images


text:
Fidaxomicin in C. difficile Diarrhea
PubMed • Full text • PDF
Clinical Question
In patients with Clostridium difficile-associated diarrhea, is treatment with fidaxomicin non-inferior to vancomycin in terms of clinical cure?
Bottom Line
Fidaxomicin was noninferior to vancomycin in achieving rates of clinical cure among patients with Clostridium difficile-associated diarrhea and resulted in fewer recurrent infections.
Major Points
Clostridium difficile-associated diarrhea (CDAD) is a major adverse effect of antibiotic usage and its incidence is on the rise, particularly among hospitalized patients receiving broad-spectrum antibiotics. While the Vancomycin vs. Metronidazole in C. difficile Diarrhea trial (2007) demonstrated superiority of vancomycin for severe disease, there have remained unacceptably high recurrence rates even among patients appropriately treated.
This study sought to investigate whether fidaxomicin was non-inferior to vancomycin for the treatment of CDAD. The study randomized 629 patients with characteristics similar to most hospitalized patients with either non-severe or severe CDAD, with average age 62 years and recent exposure to antibiotics. Clinical cure was achieved in 86-92% in each group, demonstrating the non-inferiority of fidaxomicin compared to vancomycin. Fidaxomicin was, however, associated with only 13% recurrences compared to 24% with vancomycin, yielding 45% fewer recurrences in the fidaxomicin group. Nevertheless, its prohibitive cost and lack of sufficient superiority data have yet to establish fidaxomicin as a first-line agent for the treatment of CDAD.
The 2012 Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile publication demonstrated a more than a 60% absolute increase in the rate of cure of recurrent CDAD over vancomycin. A comparison between this therapy and fidaxomicin has yet to be published.
Published before the 2011 fidaxomicin and 2012 fecal transplant trials.
- Discontinue treatment with the antibiotic thought to be associated with CDAD occurrence as soon as possible (A-II)
- Start empirical treatment in severe or complicated CDAD as soon as suspected (C-III)
- Avoid antiperistaltic agents (C-III)
- Metronidazole 500 mg po TID for 10-14 days for initial episode of mild-to-moderate CDAD (A-I)
- Vancomycin 125 mg po QID for 10-14 days for initial episode of severe CDAD (B-I)
- Vancomycin 500 mg PO QID +/- metronidazole 500 mg IV q8h for severe, complicated CDAD (C-III)
- If ileus, vancomycin 500 mg in 100 mL NS PR q6h as a retention enema
- ≥2nd CDAD recurrence with taper or pulse of vancomycin (B-III)
- Avoid metronidazole after the first recurrence of CDAD, including as a long-term agent, beacause of the risk of neurotoxicity (B-II)
- Prospective, multicenter, double-blind, randomized, parallel-group trial
- Fidaxomicin (n=302)
- Vancomycin (n=327)
- Setting: 52 sites in the US and 15 sites in Canada
- Enrollment: May 2006 to August 2008
- Analysis: both modified intention-to-treat and per-protocol
Inclusion Criteria
- Age ≥16 years
- Diarrhea positive for C. difficile toxin within 48h prior to randomization
Exclusion Criteria
- Receiving other antibiotics effective against CDAD (eg, rifaximin)
- Patients could receive ≤4 doses of metronidazole/vancomycin within 24h prior to randomization
- Life-threatening or fulminant CDAD
- Toxic megacolon
- Prior exposure to fidaxomicin
- History of inflammatory bowel disease
- Recurrent CDAD (>1 episode in 3 months prior to study)
Baseline Characteristics
- Age: 61.5 years
- Female: 56%
- Unformed stools per day: 8.3
- Inpatient: 58%
- Lack of response to metronidazole: 5.1%
- Treatment for C. difficile infection in previous 24 hours: 16.9%
- BI/NAP1/027 strain: 37%
- Stratified according to whether current infection was first episode (primary occurrence) or second episode (first recurrence) within 3 months before start of study
- Received study medication orally each day for 10 days
- Fidaxomicin 200mg PO q12h with intervening matching doses of placebo
- Vancomycin 125mg PO q6h
- Assessed daily for clinical cure or failure during 10-day course of therapy
- If criteria for clinical cure were met, patient followed for recurrence, by means of weekly assessment, for 28 days after last dose of study medication had been administered
- Fecal samples for toxin assays obtained at time of screening or enrollment, at time of early termination or end-of-therapy visit in case of patients with clinical failure, and at visits for diagnosis and treatment of recurrent infection in case of patients in whom disease recurred
Comparisons are fidaxomicin vs. vancomycin.
Primary Outcome
- Clinical cure
- 88.2% vs. 85.8% (modified intention-to-treat analysis)
- 92.1% vs. 89.8% (per-protocol analysis)
Secondary Outcome
- Recurrence
- 15.4% vs. 25.3% (P=0.005, intention-to-treat analysis)
- 13.3% vs. 24.0% (P=0.004, per-protocol analysis)
Subgroup Analysis
No difference in rates of clinical cure or recurrence within subgroups defined by age, inpatient/outpatient status, history of CDAD, treatment vs. no treatment for CDAD within 24h prior to randomization, baseline severity of disease, C. difficile strain, prior response to metronidazole, or concomitant use of systemic antibiotics.
- No report of PPI use, a risk factor for CDAD recurrence[2]
- The treatment was mostly limited to the NAP1/BI/027 strain[2]
- Unclear antibody levels to C. difficile toxin A, a value that may relate to risk of recurrence[2]
Sponsored by Optimer Pharmaceuticals
Further Reading
- ↑ Cohen SH et al. "Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA)." Infection Control and Hospital Epidemiology. 2010;31(5):431-455.
- ↑ 2.0 2.1 2.2 Multiple authors. "Correspondence: Fidaxomicin for Clostridium difficile infection." The New England Journal of Medicine. 2011;364:1875-1876.


text:
Forum rules | FAQ | Technical help | Announcements | New members start here
Nice! bet it's warm. I am trying to find the time to do this.
Crochet, or knitting, or both?
One needle, so crochet? I tried a few months ago since my wife does it, I got so tangled up.... Need to sit down and try it more slowly.
pretty. I love to crochet. unfortunately, my carpel tunnel is so bad, I can only do about 4 squares before my hands are killing me. that is 4 squares total, not in a day, but total then I have to stop for months. sigh. I will never get another blanket done!
I was at wal mart the other day and found an ergonomic crochet hook. It looks VERY comfortable. Check it out, maybe!
no, do NOT tell me that.. I would have to go buy one! so far, although I have made about 6 huge afghans, only one did I buy anything for (my sister's wedding gift) - I inherited every size hook from A to M and 3 HUGE boxes of year from my grandma when she quit crocheting at age 103 (she couldn't see anymore!)do they have various sizes? I need to go find these, maybe put them on my birthday list this year (my in-laws are always wondering what I want!)


text: 'Black Nativity' Trailer: Jennifer Hudson Sings in Holiday Musical Drama (Video) 6:07 PM PDT 6/30/2013 by Kimberly Nordyke FACEBOOK TWITTER EMAIL ME YOUTUBE The movie, which hits theaters Nov. 27, also stars Forest Whitaker, Angela Bassett, Tyrese Gibson, Jacob Latimore, Mary J. Blige and Nasir Jones. Jennifer Hudson sings in the new trailer for Fox Searchlight's holiday musical drama Black Nativity. The film, a contemporary adaptation of Langston Hughes' play, also stars Forest Whitaker, Angela Bassett, Tyrese Gibson, Jacob Latimore, Mary J. Blige and Nasir Jones. PHOTOS: Ho Ho Hollywood! Tinseltown's 22 Best Christmas-Themed Movies According to the official logline, Black Nativity follows Langston (Latimore), a streetwise teen from Baltimore raised by a single mother, as he journeys to New York to spend the Christmas holiday with his estranged relatives, Reverend Cornell and Aretha Cobbs (Whitaker and Bassett). Unwilling to live by the imposing reverend's rules, a frustrated Langston is determined to return home to his mother, Naima (Hudson). Langston embarks on a surprising and inspirational journey and, along with new friends and a little divine intervention, he discovers the true meaning of faith, healing and family. In the trailer, Hudson sings a revamped version of "Silent Night." The movie hits theaters Nov. 27. FACEBOOK TWITTER EMAIL ME YOUTUBE Kimberly Nordyke email@example.com @thr


text:
It's that time of year again. If you happen to be in Austin, please join me at SXSW on Friday (yes, that's Friday the 13th) where I will be talking about the intersection of brand and technology that will lead us toward creating experiences that we not only need but that we want and desire. Some highlights that I will cover during the session:
The term "Wearables" is bullshit. We need to reframe how we think about the wearable industry.
The term "wearables" shows us that we're looking at the world from a purely tech perspective. Though technology will continue to play a crucial role, it can no longer be the central focus of product efforts. Our experiences will become less about the tech and more about how it will make us feel.
Congratulations, we made it work. Now we must strike the right balance between utility, emotion, and meaning.
Currently, we're heavy on utility as we try to prove out the technology and get these new wearable devices to work. We need to strike the right balance between utility, brand alignment (adding the emotional quality and connection), and meaning (solving real problems) that will lead us toward creating experiences that we not only need, but that we want and desire.
Our technology products will become our own personal brand.
Brand is personal. The brands a person selects are an expression of that person and chosen for the way they make that person feel, or sometimes for how the person wants to feel. We're used to looking at clothing and cars this way, but it's time we start looking at all our technologies this way. We will soon select our technologies as an expression of self, as a part of our own personal brand.
"Fashion Tech" is an example of how our current approach is out of balance.
We must go beyond fashion embellishment and "snap-on" branding if we are to create products that are truly meaningful for people and resonate with people's needs.
To go past early adopters toward mainstream, we need to do better than measuring steps and putting notifications on our wrists.
The opportunity that the wearable form-factor brings to our ecosystem of connected devices, is that we now have the ability to make our experience much more personal. Whether it's making someone happier or healthier, we can use this new form-factor to solve real problems and make a world that improves and possibly saves our lives.
To solve real problems, we have to change our organizational structures, our mindsets, and ultimately our culture.
Chrono Therapeutics is an example of a company that gets it; we of course have people representing seemingly disparate disciplines – from engineers to behavioral experts to designers to medication scientists, we also have a culture that emphasizes the importance to collaborating across those disciplines to strike the right balance.
My challenge to the industry is to constantly ask ourselves these questions:
- Are we moving beyond a device-centric approach toward one that is more human?
- Are you aligning the right technology capabilities to your brand or the brand that you are collaborating with?
- Are you striking the right balance between utility, emotion, and meaning?
- Are you solving real problems?
- Does your organization have the right attitude that pulls from different perspectives?
I hope to see you there!
Info on the talk:
En Vogue: Blurring the line between brand and tech
Brand matters. As we've seen on TV, even a $20 Casio watch will excite people if it has an Apple sticker on it. In her talk, leading wearable technology and fashion expert Jennifer Darmour will reason that for wearables to have this kind of enduring consumer engagement, we need to align brand values and technological capabilities in a way that makes the experience more meaningful.
As wearable technology and the IoT collide, we'll see more technology embedded into products we use daily, from our clothing to our homes. So far, brand values have been an afterthought for these smart products but it's time to think about it the other way around – creating new experiences tied to the values of brands we love.
In her talk, Darmour will explore the intersection of fashion and technology by breaking down models of brand collaborations from Tory Birch and Fitbit to Apple and Gucci, and discuss how incorporating brand from the beginning will result in tailor-made experiences of the future.
Friday, March 13
JW Marriott
Room 205
110 E 2nd St
ATTENTION: This session requires advance signup to attend.
More info and to sign up for a seat, go here.


text:
Hidden Helmsley - the best-kept secrets of the North Yorkshire market town
PUBLISHED: 00:00 07 June 2018
not Archant
There is so much to shout about in this award-winning North Yorkshire town, including some quirky pleasures, writes Richard Darn.
Helmsley knows how to look good. With its pretty buildings, pantile roofs and magnificent 12th century castle dominating the skyline, it is a chocolate box cover par excellence, nestling in lovely countryside. But dwell here for a while and you will discover it's a lot more than just a pretty face. For despite its ancient roots and traditions this is a town full of zest with quirky pleasures alongside its better known delights.
With so much of Helmsley designated as a conservation area why would anyone start a visit in front of a grey modern warehouse? That's because of what it contains. For this is the main English Heritage archaeological store for the north and conceals a wealth of historic riches. Once kept top secret, this summer you can sign up for free tours and glimpse objects rarely, if ever, seen before in public.
It all looks a bit like the famous last scene from Raiders of the Lost Ark when the camera pulls back revealing a vast store of archaeological relics. The Helmsley version is a tad smaller, but still boasts a mass of medieval carved stone from places likes Rievaulx and Fountains abbeys, together with floor tiles from Byland Abbey (including one with a dog's paw print as part of a display of items with a canine connection!).
There are over half a million individually listed items, from Stone Age flints to First World War guns, each with a compelling story to tell. Favourites of mine are early Anglo Saxon coffins lids made from pine (which must have been imported) together with swords, arrow heads and a vast horde of Roman items, such as a floor mosaic from the little known Roman villa at Beadlam, a few miles to the east. Fascinating tours take place on June 6th, July 4th, September 5th and October 3rd. Book in advance on 0370 333 1183.
There's seamless transition between the built and natural environment around Helmsley as befits a town whose original name meant clearing in the trees. Take a few strides along the Cleveland Way from the town centre and you are in exquisite countryside with fabulous views of Helmsley Castle and the famous Walled Garden behind you and fields and woodland ahead. Many of the forested areas around Helmsley date back thousands of years and are incredibly important wildlife havens. Just one of the many mature oaks can support up to 350 different species of insect and over 30 kinds of lichen. Cutting edge research on bats is also being carried out nearby. Wild flowers abound both in woods and alongside roadside verges such as the tall and aromatic Mugwort, Lady's Bedstraw, Fairy Flax and Quaking-grass. Experts Margaret Atherden and Nan Sykes have been surveying North Yorkshire's verges since the 1980s, rating them for their plant life. They bestow many of the country roads around majestic Rievaulx Abbey with top scores for floral biodiversity, adding seasonal beauty to this already sublime landscape. Their book Wild Flowers on the Edge is a brilliant walking companion and available from place.uk.com priced £9.99. The Helmsley in Business initiative has also teamed up with Ryedale Council to create a free app for smart devices listing half a dozen lovely walks locally of various lengths. You can download them in printed form if you prefer at visithelmsley.co.uk
Local produce is a big thing these days and beer has been in the vanguard of restoring local distinctiveness to our fare across Yorkshire. Helmsley got its own little artisan brewery in 2014 when former teacher Kyle Boote pulled the first pint of beer at his bijou bar on Bridge Street. Since then the Helmsley Brewing Company has gone on to develop iconic tasting brews including Howardian Gold, Yorkshire Legend, HiPA and Striding the Riding, the official beer of the Cleveland Way. Meanwhile other local producers have their own showcase with monthly indoor markets in the town hall (third Friday) where you can expect to find Yorkshire extra virgin rapeseed oil, jams, Dexter beef, vegetables, honey, vegetarian and vegan foodstuffs. The market opened in July 2017 and has gone from strength to strength and organisers are looking to broaden the offer by finding other local producers to take part. It's such a refreshing change to see this sector thriving and let's not forget Helmsley has its weekly open air market every Friday.
Small independent shops have always been a feature of Helmsley and it's great to see the world sitting up and taking notice. Not so long ago it was declared Britain's Best Market Town and handed £80,000 worth of prize money to invest further in training for local businesses. That's a terrific accolade given the competition from elsewhere. Interiors, antiques, butchers, cafes and delicatessens are well represented, with barely a chain store in sight. It's difficult to overstate the advantage that gives Helmsley and it's also a signal to less successful market towns in the county. One business that really caught my eye was the workshop of stick maker Keith Pickering, a former trout farmer. Ancient crafts are thriving in the North York Moors and Keith has turned his hobby into a profession. His walking sticks are made from locally grown hazel and often feature beautifully carved animal heads. You can even have the face of your very own pet dog immortalised on the handle. His creations are sold around the world and he even made a ceremonial crook for Justin Welby, now the Archbishop of Canterbury.
Helmsley has also become adept at staging special events to draw in new visitors and counteract seasonality; which is a good way of flagging up the first ever National Town Crier competition to be held in the town on July 21st, attracting entries from as far afield as Bermuda and Canada. The castle and walled garden are just two of the venues and there'll be a parade through the market square before the winner is revealed by the judges. It's just one of amazing things Helmsley has to shout about these days.


text:
Fortunate Ones ft. Sydney Wayser - TRL
- Artist: Fortunate Ones
- Track: TRL
- Producer: Fortunate Ones
- Album: Honest, Regardless
Chingy, Punjabi MC, Dem Franchize Boys, Afroman—each seemed poised to take over the game for one shining moment, and all have fallen off in the years since. On the final pre-release single off their next full-length, North Jersey duo Fortunate Ones contemplate the fates of these and numerous other TRL era hitmakers-turned-has beens. Rather than mocking them, however, Genetics and Serge take the aforementioned acts as a warning to keep progressing artistically, lest they themselves become complacent and fade into obscurity. Joining the twosome over their own ethereal, sample-driven production, French-American singer/songwriter Sydney Wayser provides a quirky, addictive guest hook. Fans will be able to find this cut, previous single Girl, Interrupted and much more on the Fortunate Ones' Honest, Regardless LP, droppnig digitally at an unspecified date in the near future.
Update: TRL is no longer available for stream.


text:
LIVING WITH GRATITUDE! Yes, this is the attitude we all need to have because everything is truly here to help us NOW !
By Freja Enjoy
Grounded Collective Unity !
Yes, this is the attitude we all need to have, because everything is truly here, to help us, NOW !
By Freja Enjoy
Grounded Collective Unity !
~ NOW WE ALL HAVE THIS GREAT G R A T I T U D E - Beloved Light Family – G R A T I T U D E - When we L O O K at Everything Around you with Gratitude – GRATITUDE - we become more Open to Receiving Anything that Helps us, E V E R Y T H I N G, Everywhere Around us is here to Help Now! ~ Everything is B E A U T I – F U L around us and if we do not see it then we stop and change our F O C U S - NOW! This is what we do, we Change our own attitude and focus on the B E A U T Y and W I S D O M that exists in all L I F E around us. ~ The E N E R G I E S are so Beautiful in all the Colors of the Rainbow is everyone and we have Access to them now as they G R O W for Every Moment.
~ These Wonderful Energies that Flow InTo US NOW have an Increased Amount of I N T E N S I T Y Now ~ and We Are Preparing for the A M A Z I N G F U L L M O O N we get on Monday 7/8 ~ On top of that the G R E A T L I O N S G A T E 2017 the 8/8 ~
~ So Let us All Honor this Truly Sacred Passage of Our Ascension. We Will Embody Our Divine Creator – Being-ness Now ~ As We Breathe, We Will and We Are The Impeccable Compassionate Way-showers As Things Amplify ~ The External Effects are what they are ~ Look and See the Apparition and Vision within your Heart. Let Every Thought, Word and Activity Align with New Earth ~ Send that Divine Love Light forth to all Creation ~ and BE in Divine Service to Divine Source.
~ Now we have an Incredibly POWERFUL week Ahead of us so let`s be Grounded Collectively through Heart Centeredness in our thought, word and deed ~
~ Please join Us for the Global Unity Meditations this SUN-day as preparation for the Lunar Eclipse and Lion's Gate this week. We amplify the High-Vibe Human-Beings Heart Grid and Crystalline Grid to co-create the highest outcomes for the Primary Ascension timelines.
~ Details on the SUN-day Unity Meditations at 8:11am, 11:11am and 5:11pm PT can be found at the link below.
Here are our collective focus points for August:
SUN-day August 6: Global Unity Meditations
Monday August 7: Full Moon (11:12amPT) and Partial Lunar eclipse
Tuesday August 8: Lion's Gate peak
Friday August 11 – SUN-day August 13: Cosmic Trigger
SUN-day August 13: Global Unity Meditations
SUN-day August 20: Global Unity Meditations
August 21: New Moon and Solar Eclipse
August 25: End of August Gateway, connects to September 21-25 Equinox Gateway
SUN-day August 27: Global Unity Meditations,
futher info. go to : http://www.sandrawalter.com/pre-eclipse-unity-meditations/
In Divine Love, Ligth and Divine Service
Freja Enjoy
ForRunner/Ascension Guide/
Donation No.2 - I like to give a DONATION of $20
Thank you for your donation to me.
Freja Enjoy


text:
No matter what your position on the various contentious issues in The Beacon, one point is irrefutable: but for The Beacon's reporting of it, most of us would never have heard about it.
We are blessed to have The Beacon as our own "hometown" weekly, and I offer my thanks to Charlie Prince and his mostable staff. All too often we take for granted those things that serve us well.
One only look to Columbus, where last fall The Dispatch bought virtually every printed newspaper or magazine in the central Ohio area, from all suburban publicans, to Columbus Monthly, even the so-called "Other Paper"! When an area has one source of news only, the owners of that news monopoly have incredible, unbridled power*.
Even though Charlie and I disagree on almost every national issue, I have no doubt about his love and caring for our glorious mud puddle and it's people. Thanks again, Charlie – and keep up the great work!
Pete Myer
* I filed a complaint with the Feds
about this monopoly, but got nowhere,


text:
11 Mar 2014
Launched in Germany in 2011, PMI's 'Be Marlboro' campaign carries the message, "Don't Be a Maybe. Be Marlboro". It associates smoking the brand with a youth-friendly lifestyle of risk-taking, exploration and freedom.
The campaign also features images of attractive young people partying, falling in love, playing music, and engaging in adventure sports. It tells young audiences that "Maybe never fell in love" or "a maybe is not invited", and that they should define themselves by choosing to "Be Marlboro."
Court finds campaign violates advertising law
In October 2013, a German court banned the campaign, finding that it encouraged children as young as 14 to smoke. This was in violation of Germany's tobacco advertising law.
Similar complaints have also been filed in Brazil, Colombia and Switzerland.
The call to end the campaign is found in a new report, titled "You're the Target", issued by the Campaign for Tobacco-Free Kids, Alliance for the Control of Tobacco Use, Corporate Accountability International, FCA, InterAmerican Heart Foundation and Southeast Asia Tobacco Control Alliance.
The report also calls on governments to enact comprehensive bans on all forms of tobacco advertising, promotion and sponsorship in accordance with the WHO Framework Convention on Tobacco Control (FCTC).
Low, mid-income countries targeted
Despite the German court's findings, PMI continues to aggressively roll out the campaign globally, especially in many low and middle-income countries struggling with high smoking rates and related death and disease. These include Argentina, Brazil, China, Colombia, Indonesia, the Philippines, Russia, Saudi Arabia and Ukraine.
"This report offers further proof that despite its denials, the tobacco industry does target teenagers as future smokers," said FCA Director Laurent Huber. "We urge Parties to the FCTC, and all governments, to enact comprehensive bans on all forms of tobacco advertising, promotion and sponsorship."
Other findings from the report show that the campaign:
- Uses themes and imagery that track the recommendations of previous PMI internal research documents on marketing to kids.
- Was created by Leo Burnett, the same advertising firm responsible for the Marlboro Man campaign, which made Marlboro the world's best-selling cigarette brand.
- Used numerous marketing tactics that are effective at reaching youth and have been banned in many countries. These include advertising on billboards, bus stops, outside retail stores, music event sponsorships, beach tours, online promotional videos, interactive promotional booths and large cigarette displays.
- Appears to violate PMI's marketing standards, published on its website, which state, "We do not market to children or use images or content that might appeal to minors."
More information
- Download: "You're the Target" report (PDF 8.6MB)
- The WHO Framework Convention on Tobacco Control
- List of Parties to the treaty


text:
SDR benefits
Benefits to depositing in the Stanford Digital Repository include:
- Confidence that digital content is safely and redundantly stored now and into the future, regardless of inevitable changes in storage systems.
- Reliable access to digital content from persistent, unchanging web links (PURLs), so that citations and references to deposited content do not break.
- Control when deposited content is made public through the use of an optional embargo, deferring public access for a specific period (typically no more than three years) while the content is protected from loss or data corruption in the SDR.
- Broad visibility and embeddability of content through a rich information discovery environment that leverages SearchWorks, the library catalog, and the latest advances in search, browse, and data-linking technologies.
- Support for intellectual property rights and licences by displaying attribution statements and applicable license information.
- Delivery of content via a suite of integrated web applications for resources of all types and formats.
- Digital preservation expertise covering the full lifecycle of digital content preservation, including: content capture and encoding; metadata specifications; and file format migration.


text:
Our webinars feature experts from the field that connect you with new research, best practices, and innovative service integration strategies. Our webinars are free and allow both presenters and audience members to participate remotely.
The following are free recordings and resources from past webinars. To learn more and register for upcoming webinars, visit our Calendar of Events.