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The Microsoft Surface Pro 3 can probably replace your laptop. The big question is: Are you willing to pay the price and make some compromises in order to let it?
Microsoft Surface Pro 3
Incredibly thin, light, and fast-bootable for a full-tilt Windows computer. Forget apps; it runs full-desktop software. Durable build and attractive physical design. Its 12-inch, high-resolution touchscreen is great for watching movies and working in desktop mode. Cleverly designed kickstand offers a lot of freedom for the lap and table positioning.
Hardware is a bit too big and heavy to use as a handheld tablet. Pricey compared to laptops with similar specs. App ecosystem lags behind those of iOS and Android. Type Cover should be included with the tablet, not sold as a 0 extra. Most Type Cover color schemes are fairly hideous, negating the beauty of the hardware.
How We Rate
- 1/10A complete failure in every way
- 2/10Sad, really
- 3/10Serious flaws; proceed with caution
- 4/10Downsides outweigh upsides
- 5/10Recommended with reservations
- 6/10Solid with some issues
- 7/10Very good, but not quite great
- 8/10Excellent, with room to kvetch
- 9/10Nearly flawless
- 10/10Metaphysical perfection
The latest productivity-minded tablet PC out of Redmond is an outstanding piece of hardware. If you want a leaner, lighter, full-featured, touchscreen-equipped alternative to a Windows laptop, it is well worth considering. It's less than half an inch thick, weighs less than two pounds and boots up in under 10 seconds–sometimes as quickly as five. It feels absurdly light in your laptop bag; I actually had to check whether it was in there a few times. Just as importantly, its charger is super-light too.
The version of the Surface Pro 3 I tested was the mid-range model in the lineup, built around a 1.9GHz Intel Core i5 processor with 8GB RAM and 256GB storage. It costs $1,300. You'll need to tack on another $130 for the essential Type Cover. It only does Wi-Fi (no LTE for you), and the battery life largely depends on whether you're streaming Netflix for several hours straight. I got roughly 8 hours of usage from intermittently typing, downloading software, installing it, listening to music, and watching a few minutes of video here and there. When I fired up Netflix and just let it ride, it drained the battery in about five hours.
If you're looking for the type of tablet experience you get from an iPad, do not buy it. The Surface Pro 3 is good, but it's a completely different animal. It's the type of device that makes sense in an office environment, a powerful grab-and-go machine fit for running to your next meeting or working on the train. But the world has generally made its mind up about what tablets like the iPad are for. They're for reading and playing games and watching movies and firing up IMDB to quickly look up what else Scott Bakula has been in.
The Surface Pro 3 can do all those things. It also can crank out spreadsheets and run Photoshop or AutoCAD, just like a laptop. But these days, many people want physically distinct devices for work and for play, not a half measure solution that does both. Changing hardware triggers a different state of mind. I'm working, I'll use my laptop. I'm playing, I'll use a tablet. You need breaks from both.
The Surface Pro 3 does the "play" side of the fence quite well, just in an entirely different way. It's a very nice portable touchscreen PC, and it also excels in some ways as a tablet. It's particularly great as a lean-back video-viewing device, not just because of its nice screen and workhorse internals, but also because of its versatile kickstand. And when you're using it as you would a tablet, its 2,016 x 1,440 touchscreen looks sharp and responds smoothly to your pokes, swipes, and taps.
It's just more of a tablet PC than a tablet, a touchscreen-equipped productivity machine instead of an app-centric coffee-table device. It just feels a bit too bulky for prolonged handheld usage. It's a much better TV than it is a book.
The app situation doesn't do it many favors, either. There are plenty of big-name apps like Netflix and Photoshop Express and Threes! and Dropbox, but there are just as many big names missing from the Windows Store. No Spotify, no Instagram, no Candy Crush Saga (for better or worse). You just aren't getting the same app ecosystem or attention from app developers as you'd find with an iOS or Android device.
It's just more of a tablet PC than a tablet, a touchscreen-equipped productivity machine instead of an app-centric coffee-table device.
But this is where the Surface Pro 3 swings open doors other tablets deadbolt shut. This is a full-bore Windows 8.1 computer. You're not stuck in some appless void because you can download and install full desktop versions of GIMP and Spotify and play Flash games in your browser. And that browser doesn't have to be Internet Explorer because you can download Chrome or Firefox or Opera or any browser that runs on Windows 8.1. The Store may be barren, but the overall application ecosystem is far more robust than iOS or Android, even if it isn't necessarily optimized for a touchscreen device.
When you're using that software, the Surface Pro 3's touchscreen and included Bluetooth pen can breathe new life into traditional desktop applications. The pen looks, feels, and acts like a ballpoint pen–you hold the purple button down on the butt end of the pen for a few seconds, and it pairs to the tablet–and it's impressively precise. Writing with it feels natural. In OneNote, I was able to write legibly within a single row on a digital sheet of graph paper. In GIMP, the pen gave me very precise control over image-area selections–much easier than using a mouse. And you have never seen Microsoft Paint shine like this! For people who use Windows and prefer taking handwritten notes, sketching, or fine-tuning images, it offers benefits over traditional laptops without having to buy extra peripherals.
The Surface Pro 3's kickstand is mighty important to the overall experience too. For the most part, it's wonderful: It stays rigidly in place across roughly 136 degrees of motion instead of locking in at a couple of angles like previous versions. This gives you a ton of freedom in finding and finagling the best ergonomic match for your lap. When you're using the Surface as a tablet, it comes in handy due to the larger size and weight. One potential weak spot is that the kickstand's hinge system is exposed to view, and it seems to be made out of a very hard plastic. It doesn't seem like it will break or lose friction with repeated usage, but the exposed mechanics may increase the chances of that happening.
Which brings us to the backlit Type Cover keyboard, which really should be part of the Surface Pro 3 base package instead of a $130 extra. It's essential. If you're using the Surface Pro 3 with its strengths in mind, you'll be using it in landscape orientation, in desktop mode, with this keyboard cover attached. And when it's set up that way, the Surface Pro 3's screen seems like the perfect size and shape.
The Type Cover is bigger and better now, but the black version is the only one that isn't garish. It has a second magnetic strip that runs lengthwise across the top of the keyboard. Fold it upward and the keyboard now latches onto the Surface Pro 3's lower bezel, giving you a bit of downward slope on the keyboard to make on-your-lap typing a bit more comfortable. It feels oddly hollow when you're typing on your lap. The keyboard works best when laid flat on a table.
There is one particular posture where the Type Cover is most awkward: Sitting on the ground, or in bed, with your back against a wall. I just couldn't find a combination of the kickstand angle and the keyboard angle that felt right; it needed either a heavier keyboard or a longer kickstand. There's also a trackpad below the keys, and it's bigger this time around, which is a welcome addition.
It does its job, but you don't have to use it. The Surface Pro 3 has a USB 3.0 port for a real mouse, a thumbdrive, or a beefier USB drive. It's closer to the top edge of the Surface in landscape mode, so your USB mouse cord will dangle down from the port in dorktacular fashion. Still, being able to plug in a mouse and go to town is great option. There's also a Mini DisplayPort interface above that USB port, as well as a MicroSD slot hidden under the kickstand. When the Surface Pro 3's $200 docking station comes out later this year, the charging station will offer four USB connections, an Ethernet port, and support for external monitors.
During my hands-on tests, which consisted of typing out this review, downloading and running most of the software I usually install on a Windows machine (Spotify, GIMP, Netflix, a few games, Dropbox, etc.), and trying to drain the battery as quickly as possible via Netflix streams, I didn't notice any performance compromises as compared to any laptop I've used for work. In terms of hardware compromises, there are a few: The speakers are comparatively weak and tinny-sounding, you don't get the same array of ports or a user-serviceable battery as you do on a laptop, and as much as the Type Cover makes an admirable effort, it can't quite live up to the comfort of typing on a decent laptop keyboard.
Ultimately, whether you'd like the Surface Pro 3 to replace your laptop boils down to a value proposition. Is it worth paying a premium for an ultra-slim device that provides full Windows PC functionality? That is what this machine is, and if you are the target market for it, you will use it as a laptop 70 to 80 percent of the time. Similarly configured Windows laptops with touchscreens, Intel Core i5 or i7 processors, 8GB RAM, and 256GB of storage cost at least a few hundred dollars less. It's a machine that makes a ton of sense for business deployments, road warriors, casual photo editors, and artists. With the Surface Pro 3, you're paying not just for the individual components, but for the sheer thin-and-lightness of it all.
When you buy something using the retail links in our product reviews, we earn a small affiliate commission. Read more about how this works.Go Back to Top. Skip To: Start of Article.


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Record-Breaking Thread
- Updated
Just posted some pics of my latest Lego adventure. You know... If you're interested. I wanted to post the short video I made here. But, it doesn't seem to want to let me do that. Perhaps I'll try elsewhere.
EDIT: Try here... https://backfires.caranddriver.com/videos/2038845
And here... https://backfires.caranddriver.com/photos/2543822
Had my first eye surgery (more like first surgery) in my 48 years of existence. I think my mum was more freaked out than I was (despite her having had the same surgery 3 years back). I was in and out under 1.5 hours (back to work by lunch - that resulted in my mum going ape poop on me). The actual process took under 2 minutes. Next one in 1.5 month's time.
I did some research and most folks over the age of 40 with myopia will eventually require laser iridotomy.
Saturday - The lawn got mowed, though it's growing the slowest it has this season (typical). I finished off the Sci/Fi mini-series of Dune last night and anticipate starting Children of Dune tonight. And I ZONKED last night so hard that my wife had to wake up up at 10:30 this morning, reminding me that I had a haircut today!
Check me on this, but I think I'm getting old! [smh]
Fay brought bands of wind blown downpours with occasional thunder that soaked everything but didn't bring flooding and damage some area's north and south of us saw with multiple inch per hour downpours.
A few interesting sightings from today. Only my second ever sighting of a GT3 Touring, and first time seeing either an NSX or Camaro ZL1 1LE in quite a while.
Sunday - Yet another in a series of my wife's grandkid's birthdays yesterday, which went well enough. I did indeed dive into Children of Dune last night and continue to be curious about what Denis Villeneuve will bring to HIS version of Frank Herbert's classic.
Was working on this earlier today. It will become a mount for the brass plaque made to memorialize my FIL. I only need to drill the holes needed to mount it and stain it. I'll post another pic when I've made more progress.
Lots of open wheel racing this weekend.
Indy cars at Road America had two great races with a big field of rookies living up to their their potential. Scott Dixon (the opposite of a rookie) won yesterday's race and Felix Rosenqvist ran down Pato O'ward for the race 2 win. Will Power was a lap one wrecking ball knocking Ryan Hunter-Reay into the wall at turn 1 and Graham Rahal into the wall at turn 3 before running himself off track at turn 14 causing a yellow that allowed him to come in, change tires, broken nose and rejoin with a back of the field penalty earned from earlier contact. Both races are worth watching on NBCSN as the starts and restart were frequently breathtaking.
Have raced Road America many times and truly love the track and Elkhart Lake. Both are worth a visit if you ever get the chance..
F1: After Hamilton's perfect qually lap in heavy rain Saturday, 1.2 seconds ahead of Max in P2, Sunday Lewis had a clean start and never looked back. Bottas ran Max down taking P2 so the podium was settled well before the end. Great battles mid-pack with Lando Norris winning Indy lights going from P8 to P5 on the last lap. Stroll, Perez, Ricciardo and Norris provided lots of wheel to wheel entertainment. Leclerc took himself and teammate Vettel out on the first lap pre-empting Seb from taking himself out later in the race. Ferrari seems to be answering the "What could possibly go wrong?" question every race.
Monday - Enjoyed golf in the afternoon and Perry Mason in the evening yesterday. Not much on the calendar for today, but I'm sure something will come up.

subset: commoncrawl


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As much as you may love your soft, dreamlike pillowtop mattress, you probably hate the way the sheets come off just as much. It's hard to find a set of sheets that fit just right when your mattress is deeper than most.
Thankfully, that's what sheets with deep pockets are for! If you never knew this was a thing, get ready to have your mind blown.
Here are 3 of the best sheets on Amazon for thick, soft mattresses.
1. Lullabi Linen Brushed Soft Microfiber Sheets
First up on the list is this Lullabi Linen set of microfiber sheets. Not only do the deep pockets allow the sheets to stay on, but the material they're made with create the ultimate sleep oasis for you.
All you have to do is order these sheets and get settled. You'll never have to deal with re-fitting the sheet over and over again – except for when washing, of course!
2. Cosy House Collection Elegant Bed Sheets
The next set of sheets you should consider investing in are the Cosy House Elegant Bed Sheets. Think of every (nice) hotel bed you've ever slept in. It was probably soft yet firm in all the right places and had a bit of depth to it.
Now, Cosy House is providing you with a way to bring that same luxury into your home. You already have the ideal, vacation-like mattress, but you need the sheets to go with it. Choose these for a good night's sleep every night, not just when you go away.
3. Southshore Fine Linens Deep Pocket Sheet Set
The final set of luxurious deep-pocketed sheets to try are the Southshore Fine Linens 21-inch pocket sheet set. That's right – these sheets can perfectly wrap around a 3-foot thick mattress.
Well, the best fit will be for a mattress that is under the 3-foot maximum, but it's hard to find something that thick anyway. This sheet is the perfect solution for whatever you have at home. It will wrap around just right and stay on in a way that's snug but not tight.
You don't have to worry about the sheets looking sloppy anymore, as most people experience when they think the only solution to a thick mattress is to buy sheets a size up.
Instead, invest in what has actually been made with your mattress in mind. Get your hands on the Southshore 21-inch sheets, put them on the bed, and feel the difference the right fit makes.
Compare All the Best Sheets on Amazon
If you're already dreaming of curling up in your sheets after a long day – hold up. You still have to buy the ones you want!
Take your time to compare the pros and cons of all the best sheets on Amazon listed above. Maybe even do a bit of outside research on other options and price differences, too.
Just be sure not to put this off. The sooner you put the right sheets on your bed, the faster you'll be able to get the sleep (and stress-free bedroom maintenance) you deserve!
For more buying tips like how to search Amazon like a Pro, click here.


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Pepper and Salt Denmark, this winery restaurant came highly recommended by family in both Albany and Denmark so we took the chance to stop in and WOW! The beauty and ambience of this place is unbelievable, the grand entrance, clean crisp white interior and views of the greenest rolling hills and valley OG-EM-GEE!
The staff have been there long term and can answer every question you could ask! Inside was cosy with a lit fire crackling in the background and material dividers hanging from the ceiling shielding the bright sun through the high glass walls. Herbs and other vegetables can be seen growing outside in abundance.
Location: Forest Hill Vineyard, 1564 South Coast Highway, Denmark, WA
Opening Times:
Friday 12–10pm
Saturday 12–3pm
Sunday 12–3pm
Monday Closed
Tuesday Closed
Wednesday Closed
Thursday 12–3pm
Kid Friendly: Yes and No (you can definitely take the kids, but it is a nice restaurant)
Pram Friendly: Yes
Mode of activity: Eats
Contact details: www.pepperandsalt.com.au
(08) 9848 3053
The meals came out rather quickly, which is perfect when you have kids. The wine was on point! Which explains the fifty-something-dollar price tag (ouch!), however, I would rather open and finish a bottle for $50 than open one for $30, drink one sip and tip the rest out. They also SPLIT BILL!!! Say What!!!!!
There was a diverse crowd, other families with babies, people on holiday along with older couples, so it was very comfortable despite being somewhat fine dining. Endless things for the kids to explore outside; grape vines, forest and copious amounts of grass fields! Let them expel all that energy and then hopefully with a full belly they will nap on the way home! (fingers, toes and arms crossed!)
Link to the menus can be found here:
The fam was right, it was defiantly worth stopping in here!
Tash & Linds
X x x
TW links:
Instagram –www.instagram.com/tribe_wild
Facebook – facebook.com/tribe_wild
Find places to visit in Albany and Denmark
Find more family friendly restaurants
- Joey's Swan Valley Diner - January 20, 2019
- Serpentine National Park - May 15, 2018
- Pepper and Salt Denmark - September 5, 2017
- Bluff Knoll Cafe - September 5, 2017
- Black Cockatoo Cafe Kojonup - September 5, 2017
- Stable BASE WA - August 15, 2017
- Pink Salt Wholefoods Cafe, Ellenbrook - July 25, 2017
- Mummies Who Walk ("MWW") Top 10 Pram Friendly Walks - June 22, 2017


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Thursday, July 18, 2013
A True Biblical Evangelist In Modern America
I was reading in my devotions one morning when I came across this passage in Luke 10:2-4 NIV. He told them, "The harvest is plentiful, but the workers are few. Ask the Lord of the harvest, therefore, to send out workers into his harvest field. Go! I am sending you out like lambs among wolves. Do not take a purse or bag or sandals; and do not greet anyone on the road.
A few weeks ago I meet brother Lawrence. I will spare you the details on how we meet, but we did and I have since spent some time with him in the neighborhoods. Money never come into play at all. Brother Lawrence calls himself a street preacher. I've yet to see him preach on the streets, but I've heard about it and I am amazed. He has told me many stories of him and Jesus in the streets as well. The actual preaching on the street aspect however is not the part that I see as the worker working in the harvest, but rather everything leading up to it.
The first thing is that nobody is a stranger and he knows how to engage people quickly and as well seems to determine even faster if they are ripe for the harvest or not. He invites, inquires, challenges and connects. He is always looking for a person of peace that will welcome him and guide him to the local harvest field. He greets people for who he sees they will be in Christ and not how they are without Him.
The second thing is that brother Lawrence knows where to find the harvest in a community or how to inquire where to find the harvest in a community. He does not look for the wealthy or the well to do, yet God can easily put them in his path as well. Brother Lawrence looks for the least of these in the area.
This evangelist has wisdom and is Spirit Led. Where he goes, he is led by the Lord as the Spirit works before him. After 20 plus years of ministry I've seen my fill of the typical self made evangelist who comes to preach to the church crowd , gets paid and moves on to the next church crowd. This evangelist is different and he actually works in the fields with the church pastor or people and He trust His Father above to meet his needs as he travels along . Now I know what a true biblical evangelist looks like. He has no demands or expectations and is targeting lost people in a community verses those already professing Christ ( as weak as they might be). I discovered how few biblical evangelist there actual are out there in the highways and bushes of our communities.
I see now that a traveling evangelist and a traveling revivalist are two completely different calls. What we really see today if at all are revivalist who travel to preach to the saints with occasional conversions of those who are mixed in with the saints.
Lord grant us more brother Lawrence's in our days who go into the areas of our communities where most people have abandoned. Evangelist who preach the truth without a pulpit or microphone.
The harvest is plentiful but the workers are few.
Thanks be to God for the biblical evangelist.
Posted by Peter Migner at Thursday, July 18, 2013
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text: Started the new year with a cake decoration order for some ponies! Well, they really wanted a whole cake, but since New Year's is a bit busy I just didn't have time to fix one, so just making decorations was a compromise . I had seen ponies like these made in clay and I think they're really cute, so I tried to make them just as cute but in an edible material. I mixed sugar paste and modelling paste together and that worked out really nice to work with. And look how well they fitted on this really cute cake!


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When you're first setting up Drift, it is extremely important to set up your hours correctly since they can affect your other settings and features like playbooks, routing rules, and more!
So, let's clear up the details...
There are three time/hour settings in Drift app:
- Chat Widget
- Teams
- Individual Status
These three settings will help you have more control over your online/offline default greeting, playbooks, and Drift teams.
For example, these settings will let your Drift account know when to automatically switch from firing the online playbook to the offline playbook 🙌🏼
1. Chat Widget Hours
This setting affects your chat widget icon, your Default Greeting, and enabled playbooks depending on your Targeting display conditions. You can set this up in Settings > App Settings > Chat Widget > Hours & Targeting (here).
While the default greeting automatically follows this widget setting, playbooks must be configured to follow them. You can set this up in your display conditions. The display condition, "when "Drift is Online" (or Offline)", follows the chat widget settings.
Scroll down on the same page to find the setting to set Drift offline if everyone's away …
Ready to set it up? Read step by step instructions for hours & targeting settings here!
2. Team Hours
You can create different teams of your users, and edit their hours within their settings.
Set this up here (settings > team settings > teams).
3. Individual Status
This is when you manually change your status, as a single agent. You can do this by clicking on your avatar on the bottom of your lefthand sidebar.
You can track when your users are Available and Away using the User Log feature.
Check out these help docs to learn more about team settings, different user roles and the difference between status vs. mode.
How this impacts routing
If you use lead routing, you'll only be automatically added to conversations when you're "Active". You won't be added to any conversations when you're "Away". Get more info about Active and Away status here.
A lot of our customers ask us why or why not someone was routed into a conversation when they were online or offline.
So, to make this decision-making process more transparent, we've made a new feature that shows which users were Available ✅ and which users were Unavailable 🚫.
Here's an example:
Sometimes, users are marked Unavailable here even when they are online. There are a few possibilities on why this might have happened:
- Their calendar isn't connected when the bot is supposed to drop a calendar
- They're already present in the conversation
- They've reached their conversation limit.
For Pro plan and up, Team Availability helps take care of those times when you're marked Available but aren't around to respond.
Learn more about the Team Availability bot skill here.
Questions or Concerns? Chat with us now in the widget down below or email firstname.lastname@example.com


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- 2002 or newer
- 5 Person
- Auto
- Petrol
- 4 Door
- Air Conditioning
- CD/Radio
- Dual Airbags
- Power Steering
Minimum driving age: 18. The JUCY Travella is a large four door sedan with a generous sized boot and lots of leg room (kind of like business class). This car is great for a family or group of friends wanting a reliable, economical car to safely and easily travel around New Zealand.
Pick Up Date: Thursday, December 27, 2012, 10:00 AM, Queenstown Airport.
Drop Off Date: Wednesday, January 02, 2013, 10:00 AM, Queenstown Airport.
For New Zealand residents only.


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After months of hard work and dedicated efforts, we are proud to present you with a website designed with a fresh look to educate, engage and inspire you! Listed below are some of the upgrades we have made…
- Streamlined menus
- Simple navigation
- Fresh content
- On-line shopping cart
- Mobile Friendly for your phone
- Social medium buttons
We really want to use this platform to keep you connected with what is new on the farm and our sustainability efforts. You can meet our staff and see just how many people it takes to make our animals happy and our business successful! If you aren't able to come to a farmers market or one of our retail outlets, we make it really easy to order product on-line with an easy pick up right here at the farm! Just this month we have launched our LDF Farm Share program. Take a look our website for more details on how to join!


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Joint Communiqué between Ireland and Mexico following high-level talks
News16 November 2017
Joint Communiqué between Ireland and Mexico following high-level talks in Dublin, 16 November 2017
- The Minister for Foreign Affairs and Trade of Ireland, Mr Simon Coveney, T.D., hosted the Deputy Foreign Minister of Mexico, Ambassador Carlos de Icaza, for a wide-ranging and constructive meeting in Iveagh House to discuss the continued positive development of political, trade and people-to-people relationships between Ireland and Mexico.
- Minister Coveney's meeting brought to a conclusion the latest round of regular bilateral talks between Ireland and Mexico which took place in Dublin on 15 November 2017, following on the previous round of talks which took place in 2015 in Mexico City. The Irish delegation for the talks was led by the Secretary General of the Department of Foreign Affairs & Trade, Mr. Niall Burgess, while the Mexican delegation was led by Deputy Foreign Minister de Icaza.
- At the outset of the talks, the Irish side expressed condolences for the loss of life and damage caused by the earthquakes in Mexico in September 2017. Ireland was pleased to make a contribution of over €300,000 through its participation in the Start Fund to recovery efforts following recent natural disasters in Mexico. Deputy Foreign Minister de Icaza thanked Ireland for their support during the recovery stage.
- The two sides discussed the bilateral relationship, including a review of high-level visits and engagements. The Irish side recalled the successful visit of President Michael D. Higgins to Mexico in October, 2013, which built on Ireland's already warm relationship with Mexico. Ireland looked forward to inward high-level visits from Mexico in the coming years.
- The discussions reaffirmed the strong historical and contemporary ties that bind the two countries together and provide a solid foundation for the current and future development of the Ireland-Mexico relationship.
- The Irish side briefed on its commitment to deeper bilateral engagement with Mexico, to expanding Ireland's presence in Latin America, in particular through the recent announcement of two new diplomatic missions in the region and the forthcoming Americas Strategy, and on its ideas for strengthening Ireland's relationship with the Pacific Alliance.
- On the economic relationship, the two sides welcomed the continued strong performance of trade in goods and services between Ireland and Mexico, which reached over €2.4 billion in 2015. There was agreement on the need to further develop trade and investment links and to promote tourism between the two countries to mutual advantage.
- Ireland and Mexico expressed their commitment to a comprehensive and ambitious upgrade of the EU-Mexico Global Agreement, which is currently under negotiation and will generate new trading opportunities for Irish and Mexican exporters and investors, and looked forward to an early conclusion to the discussions.
- Recalling the long-standing and successful cooperation between Ireland and Mexico at the United Nations and recognising the commonality of interests on a range of issues of global concern, the two sides discussed how they might further cooperate in the multilateral arena, including on disarmament & non-proliferation and UN peacekeeping, and explored options for institutional cooperation between the respective foreign ministries.
- Ireland and Mexico exchanged views on good practice on diaspora and migration, and shared updates on bilateral agreements and memoranda.
- The two sides considered the existing potential for deepening bilateral cooperation in the science & technology, education and agricultural sectors. They discussed possibilities to encourage innovative collaboration on development cooperation in support of the Sustainable Development Goals.
- The two sides discussed the political situation in Latin America and exchanged views on their respective relations with the United States.
- There was an exchange of views on the UK's departure from the European Union and on EU-Latin America relations.
- Discussions were conducted in a cordial and productive atmosphere and they concluded with the two countries committing to the continued strengthening of bilateral relations in the period ahead.


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Contact us
Contact your nearest centre
You can contact your nearest centre by using our find a centre page.
Contact your nearest centre here
Contact NumberWorks'nWords
You can use the form below to get in touch with us about tuition, employment or franchise opportunities.
Your feedback - good or bad - helps us to continually improve our service to your children. If you have something to say about our tuition, centres, promotional material or this website, we'd love to hear from you.
To talk directly to your nearest centre, use the find a centre link instead.
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The 2016 Crafts and Music Event will be held at Queen Mary's College, Cliddesden Road, Basingstoke on Sunday 10th July 2016 between 11am and 5 pm.
Stall Holder Information and Booking page on our charity website.
Outdoor stalls will be in a green area alongside the entrance to indoor stalls, Indoor stalls will be spaced around the side hall and entrance foyer with a performance area in the hall, music from this area will be amplified to the outdoor area. Visitors are routed in and out of the hall passing the indoor and outdoor stalls to ensure all stalls have the opportunity to be visited by our customers.
Footfall is guaranteed as hundreds of children perform during the event and their families come to support them.
We have each ensemble perform twice during the event to ensure that there is time to visit the stalls between performances.
We have run the annual event for over a decade. 2 years ago we carried out an extensive evaluation surveying customers, ensemble parents and stall holders.
Satisfaction was high and the overwhelming majority of respondents wanted the event to remain in a similar format.
We also surveyed the first 200 car drivers attending the event as they entered the car park, and found that 168 were associated to our Orchestras and Choirs, others found out about the event from a number of other routes. Armed with this knowledge we are prioritising the most effective promotions and to promote more to the extended families as well as parents.


text: "We spent a couple of days in Arrowtown, a welcome distance from the summer crowds of nearby Queenstown. Retaining its gold-rush charm, the main street is a cluster of heritage-style shops and original miners' cottages, making it easy to imagine the lives of families who emigrated here to make their fortune panning the Arrow River for gold. New Zealand may not have seen the rise and fall of empires or had the likes of Shakespeare walk its streets, but our country has an intrepid history all its own, something I was only now beginning to appreciate."


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10:57am PT by Matthew Belloni
Kate Walsh Sues Ex-Managers Over 'Bad Judge' Commissions (Exclusive)
Kate Walsh plays a judge on her new NBC show, and now she's looking for a little real-life judicial help in a new lawsuit.
Walsh, the former Grey's Anatomy and Private Practice star, has sued her former managers at Evolution Entertainment for allegedly trying to extract a commission for her work on NBC's Bad Judge despite having been fired more than a year ago. Walsh is now represented by Untitled Entertainment for management (as well as CAA).
The complaint, filed Monday in Los Angeles Superior Court and obtained by The Hollywood Reporter, asks a judge to intervene in the dispute over Walsh's management contract with Evolution, which called for her to pay 10 percent of her income from the show to the company.
Read more 'Bad Judge' Showrunner Liz Brixius Out
"Ms. Walsh believes she that she should not be responsible to pay Evolution all, or any part, of the commissions demanded, and seeks guidance from this court to determine the proper amount, if any, that she should pay to Evolution," states the lawsuit.
Walsh and her Kitty Likes to Scratch Productions are represented by Bryan Freedman and Steven Stiglitz at Freedman & Taitelman in Los Angeles.
A rep for Evolution declined to comment on the suit.
Email: email@example.com
Twitter: @THRMattBelloni
Matthew firstname.lastname@example.com @thr


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You have now been introduced to the fundamental Git workflow. You learned a lot! Let's take a moment to generalize:
git init creates a new Git repository
git status inspects the contents of the working directory and staging area
git add adds files from the working directory to the staging area
git diff shows the difference between the working directory and the staging area
git commit permanently stores file changes from the staging area in the repository
git log shows a list of all previous commits
Click Next to complete the lesson!


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Family: Asteraceae Bercht et J. Presl
Distribution: North American species from the western part of the continent, occurring in British Columbia, Alberta, Oregon, Nevada, Idaho, Montana and Wyoming. Absent in state of Washington.
Ecology: Dry rocky hillsides, rocky meadows and grassy slopes at elevations 1500–3000 m. Blooms from May to August.
Description: Biennial to short-lived perennial herb, 5–25 cm tall at flowering, from stout taproot. Basal leaves numerous in a rosette, petiolate, oblong to lanceolate to spatulate, 20–50 × 2–8 mm, hairy underneath, margins smooth; stem leaves alternate, smaller. Heads single, terminal, 5–7 cm across; involucral bracts lanceolate, green, margins translucent and fringed, in several overlapping rows; ray florets purplish to blue, rarely white or pink, 20–70, 1–2.5 cm long; disc florets yellow, numerous. Fruit is an compressed achene with pappus of long bristles.
Note: The species name honour of British-American botanist and mountaineer Charles Christopher Parry (1823–90), who described some 100 new species in Colorado.
These images were taken in Canada, Alberta, Highwood Grass Pass (June 8, 2016).


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How are banks responding to changes in the regulatory, market, and business environments that are the result of open banking? A new Oracle and MIT Technology Review Insights Report examines the state of open banking.
Respond instantly to customer needs, offer a differentiated value proposition, and build a financial ecosystem that fuels your corporate customers' rapidly expanding value chains.
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Leverage a modern, universal banking platform to launch digital capabilities, accelerate business agility, build partnerships, optimize efficiency, and drive new value across retail and corporate banking business lines.
Reinvent customer engagement with harmonized data, streamlined processes, and agile systems. Create deeper relationships with tailored products and well-timed services.
Automate your entire lending and leasing lifecycle on a single platform, from originations through servicing to collections.
Process hedge funds, mutual funds, unit-linked insurance products, and pension products across lines of business on a single platform.
No longer constrained by tightly controlled information pipelines, consumers in today's experience economy are aware of the breadth of opportunities presented by nontraditional product sources, and expect companies to keep up. Oracle is transforming SME bank lending origination with a data-driven, progressive-decisioning platform that modernizes access to data and processes.
AI technologies can help a bank address disruption, stay competitive, and safeguard customer relationships. However, to successfully leverage AI, banks must cut through the hyperbole of technological breakthroughs and view AI as means to an end that will radically improve decision making across the enterprise and address business issues at scope and scale.
Download this Oracle Newsletter featuring insights on artificial intelligence and machine learning from Gartner Research. Learn how a realistic strategy can help banks reap the benefits of AI. Understand how a modern core banking solution embedded with machine learning capabilities is key to helping a bank jumpstart its AI journey and achieve quantifiable business benefits.
This Forrester Thought Leadership Spotlight commissioned by Oracle discusses:
One of the changes we are seeing is the speed of turnaround. The feedback we are getting from customers is that it's taking half the time on the Oracle system. Also, previously it took us four to six weeks to change a product feature. Now it takes us only a few hours.Jeff Greenslade, CEO, Heartland Bank
Lloyd Atabansi, CTO and managing director of Ecobank, discusses how the bank has streamlined customer experience, improved customer service with new offerings, and facilitated cross-border transactions for its retail and wholesale banking customers.
We get better data, better analytics, and better information back. We also gain the ability to have less touching and manual manipulation of data prior to getting to our customers. Essentially it means we are getting it right.Dan James, Director, Vixxo
We are trying to drive customer-centric processes across our channels and our brands. Oracle Banking Platform provides the architecture we wanted to deliver that experience to our customers.Tim Whiteley, General Manager, Application Development, Westpac
Oracle's new corporate banking solutions enable smarter operations for credit facilities, corporate lending, and trade finance.
Fibank has successfully introduced Oracle FLEXCUBE 12 core banking system.
New Oracle Banking Virtual Account Management simplifies transaction banking and enables operational efficiencies.


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What is the singular form of the word 'papparazzi'? Read this article about the origins of this kind of journalism and tell me.
In Your Face: Paparazzi take root in Washington (The Washington Post)
Other related articles >>>>
Paris, love, proposals … and your own pack of paparazzi (The Guardian)
Paparazzi avoidance and self defence taught to trainee nannies (BBC)
And here's a Selectivity exam you can do connected with the issue: Celebrity news (June 2015)
You can do this crossword on NEWSPAPERS
Watch this interesting TED talk >>> Does the media have a "duty of care"?
SOLUTIONS to the B2 exercise in the previous post: 1. A 2. D 3. C 4. D 5. A 6. B 7. D 8. D 9. B 10. C 11. D 12. B 13. B 14. B 15. A 16. C 17. A 18. C 19. B 20. B 21. D 22. D 23. A 24. D 25. B


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IV Chelation
The word chelation comes from the Greek word "chelos," which means claw and refers to the ability of some chemicals to claw or grab metals and minerals to transport them out of the body through the kidneys. Physicians use a variety of chelating medicines to improve health. One of the most common chelating agents is EDTA (ethylene-diamino tetraacetic acid), a synthetic amino acid. In the 1940's and 1950's, EDTA was found to be a safe and effective treatment for lead toxicity and was approved for that purpose.
It was also observed that some patients who coincidentally had symptoms of heart disease such as angina improved while undergoing lead toxicity treatment. Since that time, chelation therapy has been used for vascular disease. This use has been controversial. To date, the FDA has not approved EDTA chelation therapy for vascular disease, but the status of EDTA as an approved drug for lead toxicity allows physicians to use it for other conditions.
Chelation therapy is used to remove heavy metals from the blood stream reducing free radical damage that can cause arteriosclerosis. For this, ethylene diamine tetraacetic acid (EDTA, an amino acid) is administered intravenously. The acid binds with heavy metals such as iron, lead, and calcium, and flushes them out of the blood via urine. Chelation therapy reduces the occurrence of arteriosclerosis and, therefore, is effective in preventing heart attacks, strokes, senility, and cancers
Chelate I & II
The Chelate I IV uses Calcium-EDTA to chelate toxic heavy metals from the body, including aluminum, cadmium, lead, and more. Chelate II IV uses DMPS to chelate toxic metals and is particularly good at binding to mercury, a potent neurotoxin and endocrine disruptor. These two IV's can also be used when checking for heavy metals in the body with a "provocation" test.
How does chelation therapy work?
The exact mechanism of action by which EDTA improves vascular disease has not been determined. Several mechanisms have been proposed.
- EDTA improves cell metabolism by removing toxic heavy metals such as lead, cadmium, aluminum, iron.
- EDTA may reduce free radical cell damage by removing excess metals from circulation.
- EDTA binds calcium in the blood and favorably alters the balance of calcium and magnesium in the cells.
- EDTA reduces the tendency of blood to clot.
For what conditions is chelation therapy used?
Physicians have used EDTA chelation therapy for more than forty years to treat a number of conditions, including the following.
- Cardiovascular Disease (angina)
- Diabetic Arterial Disease
- Decreased Mental Function from Vascular Disease
- Intermittent Claudication (leg pain on exercise from poor circulation)
Chelation may also be used as preventive medicine for part of a healthy aging program.
How is chelation therapy administered?
EDTA chelation therapy is administered both orally and intravenously. The intravenous solution is composed of EDTA, Vitamin C, Magnesium, and certain B vitamins. Treatments are given over 2.5 to 3 hours generally on a weekly or biweekly basis. Most patients require between 30 to 40 treatments.
What health care approached complement chelation therapy?
Chelation therapy patients are advised to follow a comprehensive approach to their health, including diet, exercise, stress management, and dietary supplements.
Who should consider chelation therapy?
Anyone with the following medical problems could consider chelation therapy.
- Angina, heart attack or coronary artery disease
- History of artery bypass surgery or angioplasty
- Stroke, transient ischemic attack (ministroke)
- Carotid artery disease
- Diabetes
- Poor circulation of the legs
- Leg ulcers
- Alzheimer's Disease
- Scleroderma
- Heavy metal poisoning including lead, cadmium and others
- Digoxin toxicity
An initial medical evaluation is mandatory to discuss the appropriateness of chelation therapy for your medical issues.
More information about chelation therapy can be found through the American College for Advancement of Medicine.


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Operation Stand Down Rhode Island (OSDRI) was founded in 1993 when several Vietnam Era Veterans, including current Board Chairman and President Tony DeQuattro, organized to help local homeless veterans. The genesis of OSDRI was the hosting of a 3-day Stand Down Weekend. Held annually the third weekend in September, Stand Down Weekend coalesces key community, federal and state agencies in a military style encampment. The encampment becomes a one stop location for homeless and at risk veterans to access medical and mental health care, financial assistance, housing, legal, DMV, employment services and more. Since 1993, over ten-thousand veterans have received services at Stand Down Weekend.
OSDRI embarked on an ambitious effort, in 2001, to build Rhode Island's first permanent supportive housing for disabled homeless veterans. Beginning with seven units on the site of what is the organization's current headquarters located on Hartford Avenue in Johnston, Rhode Island. OSDRI has developed over 88 units of housing for homeless and at risk veteran families. These properties are located from Westerly to Woonsocket and provide veterans a choice of permanent, transitional and recovery housing solutions.
The Global War on Terror resulted in an entirely new generation of veterans returning home and presented with a variety of needs, barriers and challenges than those who came before. In 2011, OSDRI expanded its services beyond its own housing and signature outreach event. Partnering with the U.S. Department of Veteran Affairs, homeless veteran households were offered temporary financial assistance to assist in rapidly housing them in privately owned rentals. Assistance was also offered to prevent evictions through payment of rent in arears. Millions of dollars have been distributed to rapidly house local homeless veteran households and keep them housed.
Simultaneously, a robust employment and training program was created bringing together state, federal, corporate and foundation supported initiatives. These programs have moved hundreds of veteran households towards a path of economic security and independence.
Inspired by working alongside veterans and Gold Star Families of the Global War on Terror, in 2014, OSDRI's Director of Development Dee DeQuattro proposed the creation of the Boots on the Ground for Heroes Memorial. With the support and hard work of OSDRI's staff, Gold Star Families and dozens of volunteers, the Boots on the Ground for Heroes Memorial premiered Memorial Day Weekend of 2015. The display of nearly seven thousand boots adorned with flags and placards each depicting a fallen service member in the Global War on Terror was immediately embraced by the community. The memorial has been visited by tensof thousands over the course of past Memorial Day Weekends.
Complimenting OSDRI's wrap around services, the Legal Assistance for Warriors (LAW) program was permanently established in 2018. OSDRI's LAW program offers veterans pro-bono and reduced fee representation in VA and Social Security Disability Claims / Appeals, misdemeanor and traffic violations, evictions, DMV matters and other selected cases.
For nearly three decades OSDRI has been serving local veterans in need as Rhode Island's leading non-profit provider of veteran services. OSDRI continues the time honored tradition of Veterans Helping Veterans. It is staffed and led by veterans and veteran family members. It remains committed to its motto of providing a "Hand up not a Hand Out."


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AODN Units of Measure Vocabulary
"A controlled vocabulary for units of measure that can be used in Marine Community Profile metadata."
"A controlled vocabulary for units of measure that can be used in Marine Community Profile metadata."
"If you wish to be positive that you find everything there is in WAVES about a particular species, or that is in a certain series, or that is by a particular corporate body, you may use the Thesaurus Search option on the left menu. These three fields use what is known as a controlled vocabulary. For example, some authors may have used the term Atlantic cod, others may have used northern cod, or simply cod in the title or abstract of an item."
"The classification codes and descriptions are broad subject headings that are specific to various databases. (...) Each code is prefaced by another two-character code that indicates in which database or equivalent printed abstracts journal, the record originally appeared."
"The Coastal and Marine Ecological Classification Standard (CMECS) is a catalog of terms that provides a means for classifying ecological units using a simple, standard format and common terminology (CMECS uses the term 'unit' to refer to any defined entity in the standard at any level of the hierarchy; 'units' include seagrass bed, sand, lagoon, and water mass). CMECS offers a way to organize and interpret data about the marine environment, and it provides a common platform for inter-relating data.
" La Bibliothèque Bernard Liou est la bibliothèque scientifique du Département des recherches archéologiques subaquatiques et sous-marines (DRASSM)."
"The Bernard Liou Library is the scientific library of the Department of underwater and underwater archaeological research (DRASSM)."
"The ASFA Thesaurus is an indexing and searching tool. It contains the subject descriptors used to index the records which are contained in the Aquatic Sciences and Fisheries Abstracts (ASFA) bibliographic database."


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I read a couple of great posts over at BrainBasedBusiness about dealing with bad bosses. They are The Worst Bosses get Promoted, not Punished and 5 Reasons Bad Bosses Get Their Way. The timing was good because I was also reading the book When Smart People Work for Dumb Bosses. It's not because I am currently working for a bad boss, though I have had a few in my career. It's actually research I am doing for my newest emotional intelligence workshop for IT professionals.
In those posts from BrainbasedBusiness, Dr. Ellen Weber discussed some of the physical and chemical responses in the brain that escalate or de-escalate stress and conflict. Weber goes on to provide some tips for staying calm and dealing with bad bosses.
Unfortunately, we don't often get to choose who are bosses are and we could end up dealing with one at some point. Here are a few additional thoughts on working with problem people and bosses that I am working on for my emotional intelligence workshops:
Stick to business & avoid confrontation - Sometimes you may want to simply focus on getting the job done and not on confronting or "fixing" others.
Document everything - Though it takes more work, it is sometimes necessary to create a paper trail so that you have records of what has transpired.
Seek help - Don't suffer alone. Reach out to other managers, peers, or the HR department when you are struggling with a bad boss. Our relationships with others can strengthen us during tough times. I would caution against sharing your problems with peers who only inflame you or the situation.
Refocus your energies - If you find yourself under pressure from a difficult boss, it may be a good time to put your energies into other pursuits outside work. Seek out hobbies or other activities that energize and rejuvenate you.
Consider a move - You are gifted and valuable! Don't throw away your talents to those who don't appreciate them. Go to another department within the same company or leave the company if necessary. Better to leave the bad boss in the rear view mirror then continue to be under the gun.
Don't take it personally - Generally bad bosses are that way because of themselves, not because of you. After evaluating any areas where you may have contributed to the situation, and taking appropriate action, don't take anything else personally. Don't see the situation as something you have caused.
Like Dr. Weber, I would encourage you to provide your tips and feedback.


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IRS Is An Equal Opportunity Employer
No applicant for employment with the Department of Treasury - Internal Revenue Service shall be subjected to discrimination because of race, color, sex, national origin, religion, disability, age, reprisal for engaging in anti-discrimination activities, protected genetic information, sexual orientation or parental status.
In accordance with the Equal Employment Opportunity Commission's regulations (29 CFR Part 1614) and procedures established by the Department of the Treasury, a person who believes he/she has been discriminated against in connection with employment with the Internal Revenue Service must normally contact an EEO counselor with the IRS, in order to initiate a complaint, within 45 calendar days of the date of the matter alleged to be discriminatory, or in the case of a personnel action within 45 calendar days of the effective date of the action.
Any applicant for employment with the Department of Treasury – Internal Revenue Service who believes he/she has been discriminated against on any of the above-listed bases should contact:
Internal Revenue Service
2970 Market Street
Room 3B-P04.200
Philadelphia, PA 19104
(267) 941-3000 Voice


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recent decision by the House of Lords may have opened the door to higher claims
for compensation from dismissed employees. benjimin burgher looks at the likely
ramifications of the decision
the well-established case of Norton Tool Co v Tewson (1972) IRLR 86 it was
found that the compensatory award for unfair dismissal is dependent on what is
"just and equitable" when taking into account all the circumstances
regarding the financial loss of the applicant. But loss does not usually
include injury to pride or feelings. However, a recent decision by the House of
Lords in Johnson v Unisys (2001) UKHL/13 has extended the scope for dismissed
employees to claim further compensation under the Employment Rights Act 1996.
So where does that leave employers?
in Johnson
Johnson's employer, Unisys, summarily dismissed him, he claimed unfair
dismissal on the grounds that the company had failed to follow its own
disciplinary procedure. He claimed that he had not been given the opportunity
to defend himself or to provide a full explanation for any of the allegations
made against him. The employment tribunal upheld Johnson's claim and awarded
him the then maximum compensatory award of £11,000.
subsequently brought a claim in the county court for damages for wrongful
dismissal. The basis of his claim was that, as a result of the way he had been
dismissed, he had suffered psychological problems that had made it impossible
for him to find work. He claimed losses in excess of £400,000. Johnson argued that, by dismissing him in
the way it did, his employer had breached the duty of mutual trust and
confidence implied in every employment contract. The county court struck out
Johnson's claim, holding that an unfair dismissal could not amount to a breach
of the duty of trust and confidence. Johnson appealed.
of Appeal's decision
Court of Appeal, (1999) IRLR 90, held that employees are not entitled to
damages for injury to feelings or for loss of reputation caused by the manner
in which they are dismissed. In its decision, the court referred to the
ubiquitous House of Lords decision in Addis v Gramophone Co (1909) AC 488, and
the principle that an employee cannot claim damages for injury to feelings or
loss of reputation arising out of the manner in which he was dismissed.
had continued to argue that the way he was treated breached the implied terms
of trust and confidence from which he was able to claim damages. He referred to
the House of Lords decision in Malik v BCCI (1997) ICR 606 in support of this
argument. According to the Malik case, damages can be recovered for financial
loss, for damage to employment prospects or loss of reputation arising from a
breach of contract. In Malik, Lord Steyn stated that the rule in Addis was inapplicable
because the Malik claim was "based not on the manner of a wrongful
dismissal but on a breach of contract which is separate from and independent of
the termination of the contract of employment".
of dismissal
Johnson's claim was based on his wrongful dismissal, however, the Court of
Appeal held that Malik was of no benefit to him. The alleged breach of the
implied term of trust and confidence did not alter the fact that Johnson's
complaint was one concerning the manner of his dismissal. Consequently,
Johnson's claim that his employer's decision to dismiss him in breach of its
own disciplinary procedures had caused him to suffer a psychological illness,
which then made it difficult for him to find other work, was dismissed.
this an inconsistency?
is some uncertainty, underlined in the recent Court of Appeal decision of Gogay
v Hertfordshire County Council (2000) IRLR 703. In Gogay, it was held that the
suspension of a residential care worker, pending the outcome of an
investigation into an allegation that the employee sexually abused a child in
care, was in breach of the implied term of trust and confidence. The employee
was entitled to damages for the psychiatric illness she suffered as a result of
that breach.
judgment in Gogay, Lady Justice Hale said that the case should be distinguished
from the Court of Appeal decision of Johnson. This is because the complaint in
Gogay related to a suspension, which involved the continuation of the
employment relationship. Gogay could therefore be distinguished on the grounds
that it did not involve a dismissal and that it related to psychiatric illness
rather than hurt feelings. In her decision, Lady Justice Hale stated, "I
recognise that this produces the strange result that, according to Johnson, the
defendant authority would have been better had they dismissed rather than
suspended the claim. That simply reinforces my view that the sooner these
matters are comprehensively resolved by higher authority or by parliament the
remedy at common law
appeal to the House of Lords provided a gilt-edged opportunity for this
apparent inconsistency to be resolved. However, despite a valiant attempt in
the partly dissenting judgement of Lord Steyn, the uncertainty prevails. In
short, the principle in Addis is still only applicable to a dismissal and Malik
is only applied to issues of breach of trust and confidence that do not extend
to the termination of employment.
majority decision in the Lords' judgment, given by Lord Hoffmann, held that a
separately actionable remedy under common law for the manner of dismissal would
be inconsistent with the statutory system created by parliament in providing a
remedy for unfair dismissal under Part X of the Employment Rights Act 1996.
for distress
Hoffmann also commented (although not required to do so) that compensation
under Part X of the Employment Rights Act 1996, could include compensation for
distress, humiliation, damage to reputation within the community or to family
life, as well as financial loss.
Hoffmann dealt quite briefly with this issue by saying, "I know that in
the early days of the National Industrial Relations Court it was laid down that
only financial loss could be compensated (see Norton Tool Co v Tewson (1973)
ICR 45; Wellman alloys v Russell (1973) ICR 616). It was said that the word
"loss" can only mean financial loss, but I think that is too narrow a
construction. The emphasis is on the tribunal awarding such compensation as it
thinks just and equitable. I see no reason why in an appropriate case it should
not include compensation for distress, humiliation, damage to reputation in the
community or to family life."
statement seems to shatter a previous statement by Sir Hugh Griffiths in
Vaughan v Weighpack Ltd (1974) ICR 261 NIRC that, "While a dismissal may
be a distressing experience, that of itself is not a matter for
compensation…It is only if there is cogent evidence that the manner of the
dismissal caused financial loss – as, for example, by making it more difficult
to find future employment – that the manner of the dismissal becomes relevant
to the assessment of compensation. …The court believes that it will only be
on very rare occasions that it will be found that the evidence justifies an
award under this head. One would hope in any event that the decision of a
tribunal vindicating the employee by a finding of unfair dismissal, would
rectify any temporary mischief that might have occurred as a result of the
dismissal, whatever its manner may have been."
where are we now? The statutory maximum compensatory award for unfair dismissal
of £51,700 may provide an incentive for applicants to also claim distress
arising from the manner of their dismissal. Highly paid employees may now
decide to claim unfair dismissal in addition to their contractual claims. Less
well-paid employees may attempt to claim for distress arising out of the manner
of the dismissal in order to pursue higher levels of compensation.
the recovery of damages for distress, humiliation, damage to reputation in the
community or to family life arising from the manner of dismissal will be for
the applicant to prove. It will be necessary to plead these matters as separate
heads of loss, and for evidence to be called in order for the applicant to
satisfy the burden of proof in relation to the loss. Applicants will also have
to overcome the difficult issues of causation and remoteness. This is likely to
lengthen tribunal hearings and further formalise the employment tribunal
apparent inconsistency in the law remains, but there is likely to be much
greater scope for applicants to argue for additional loss in employment
tribunals. Although the House of Lords in Johnson has firmly locked the door on
the pursuit of damages arising out of the manner of dismissal under common law,
it seems that the key for another door has been provided.
Burgher is a barrister at Norton Rose employment unit


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- Home
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- Stationery & Office Supplies
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- Packing Tapes
Packing Tapes
Packing tapes are a common household and industrial item known as adhesive tapes usually used for box sealing, parcel or packing. Corrugated fiberboard boxes or gift wraps can be easily sealed through it because of the hefty adhesive pressure sensitivity. Packing tapes are helpful to close or tighten any openings and connecting suitable materials subsequently it has the property of powerful and solid stickiness which fixes on the surface with firm and strict control. Usually, the packing tapes are in two colors, the clear or transparent one and other one are brown that camouflages with the brown carton or parcel packs but now for the gift wraps attractively printed scotch tapes are also available. Another type of tapes and adhesives is duct tape which is silver in color highly strong cloth-backed and also waterproof as the strong aluminum particles are used in its manufacturing which reflects the silver shade, these tapes have a long-lasting resistance of weather conditions. Packing tapes in UAE are available in different sizes broadness, from 3 inches to 1 inch and all of these can be easily ordered from Awok, the price of packing tapes are low and it is also available in the sets to form additionally the packing tapes in Dubai are used during the shifting by using the packing boxes, moving boxes or cardboard boxes, whereas it has been called with the different name of masking tapes too. Awok provides the feasibility to shop online all type of packing tapes and other stationery and office supplies in Dubai so order now and experience hassle-free shopping experience through Awok.


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The exercise in careful control proceeds for the 2017 Toyota Camry, a perpetual smash hit that is attempting to push ahead without surrendering its roots. With agile, forcefully styled rivals nipping at its heels, Toyota is known vehicle family played last year, appeared visibly slimmer and firmer suspension tuned game in certain models. Model Camry never deterred interesting characteristics such as design custom controls that have high stability.
2017 Toyota Camry XLE Review
To manage the energy from a year ago's overhaul, Toyota has presented a Special Edition trim level for 2016. Given the life Camry XLE, four barrels Edition only specialized utp residual tension with striking 18-inch wheels, smoked tail lights, suspension system is very supportive in the performance of the car's performance. In any case, the organization realized that not everyone needs a tuner-evoke tranquility execution in driving. Furnished with more moderate bodywork, what is the style in a car is a suspension, it must entertain Camry variations durable fan that Toyota Camry has not put some distance between the bases.
2017 Toyota Camry XLE Design
The 2017 Toyota Camry Design is a five-traveler medium size car accessible in LE, SE, Special Edition, XSE and XLE trim levels. The Toyota Camry Hybrid is inspected independently.
Standard features in the premium class Camry XLE is the incorporation of 16-inch steel wheels, with a high teknolodi programmable lights, ventilation, part keyless, rear camera with 6.1 inch LCD dashboard touchscreen gadget Entune includes voice control interface directly connected to a Bluetooth phone and availability voice, Siri Eyes Free and the framework of six-speaker sound with a CD player, an assistant sound jack and USB / iPod interface.
17-inch wheels compound is a combination of an increase of the model Camry SE, the game tuned suspension, sport-themed styling outside and inside trim components, fabrics and upholstery produced beef. Audio Plus can incorporate a 7-inch touchscreen with satellite radio and HD radio system. A sunroof is also discretionary.
2017 Toyota Camry XLE Performance
Each 2017 Toyota Camry trim comes with standart performance which support by front-wheel drive, a six-velocity programmed transmission and a 2.5-liter four-barrel (cylinder) motor that can delivers 178 strength with reach up to 170 pound-feet of torque. a Camry LE with that powertrain (from 0 to 60 mph) in 8.3 seconds, which is normal for a four-chamber fair size vehicle.
The XSE and XLE trims likewise offer a 3.5-liter V6 appraised at 268 hp and 248 lb-ft of torque power straight. A XLE with Hybrid V6 can reach to 60 mph in only 6.2 seconds in our testing, a fast result for this class of vehicle with an overhauled motor.
EPA-assessed mileage for the four-chamber motor is 28 mpg consolidated (25 city/35 thruway), a couple mpg behind the four-barrel Mazda 6 and Honda Accord. The V6's EPA-assessed efficiency of 25 mpg joined (21/31) is about normal contrasted with adversary V6 motors.
2017 Toyota Camry XLE Interior
2017 Toyota Camry XLE Exterior gave prominent among the lodges of the most pleasant and airy of any intermediate size car family. There is plenty of headroom and legroom in the front and very slightly less in the back, where a much higher substance adults will ride for the time ahead. Comfortable seats with headrests suitable for tall people though, and even more surprising space in the storage compartment has a volume of 15.4 cubic feet that seem normal to size sedan.
What is seen from the driver's side is the fact, and it can also be felt by seater though. Control wise atmosphere consisting deserve great praise for the base, their natural operations. Innovations Toyota Camry XLE 2017 gets 6.1 inches rendition Toyota Entune is something touch screen frame with a standard 7-inch touch screen display overhauled in various trim levels. Design is not as fresh as the best fragments, but like other control interfaces Camry, the screen is quite clear and simple to utilize.
Tags: #2017 #Camry #Sedan #Toyota #Toyota Camry


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Pro-Russian separatists in Georgia's Abkhazia region say they have shot down two Georgian spy drones over the breakaway region Sunday. However, Georgia has denied launching any flights in the area.
The claim and denial come two weeks after a Georgian drone was downed in the same area, heightening already-strained relations between Russia and Georgia.
Russia's Itar-Tass news agency says one of today's claimed shootdowns occurred over the Ochamchira region of Abkhazia. Georgian television reports groundfire in the area and says some Russian peacekeepers have been taken prisoner. The Rustavi television report has not been confirmed.
Tensions between Georgia and Russia rose last month after Russian President Vladimir Putin ordered his government to establish closer links with Abkhazia and a second breakaway Georgian border region, South Ossetia.
On April 20th - days after the Putin order was reported - Georgia accused Russian forces of shooting down a reconnaissance drone over Abkhazia. Georgia televised a video it says shows a Russian fighter jet downing the drone. Moscow denies involvement and says the video was fabricated.
Moscow also contends the April 20 Georgian drone flight violated a 1994 international ceasefire agreement for Abkhazia. That pact permitted Russian peacekeepers in both Abkhazia and South Ossetia.
Moscow has drawn international criticism for bolstering its military presence in the two Georgian regions. Moscow calls its move a response to a Georgian troop buildup near the breakaway regions.
Abkhazia and South Ossetia declared independence from Georgia in the early 1990s, sparking fighting and the dispatch of Russian peacekeepers. Many residents in the regions hold Russian passports. Georgia says the peacekeepers side with the separatists, and has pledged to bring both regions back under central government control.
Some information for this report was provided by AP and Reuters.


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Times St. house ups Aquino's net worth
BATO, Catanduanes—That's the problem with being a millionaire. Sometimes you don't know exactly how much you're worth.
President Benigno Aquino III told reporters on Wednesday his net worth increased in 2011 because of an inheritance from his parents, the late opposition leader Benigno "Ninoy" Aquino Jr. and former President Corazon Aquino. However, he said he did not want to give an exact figure because he might get it wrong and end up being in the news for underdeclaring his net income.
For 2010, Mr. Aquino declared a net worth of P54.9 million in his statement of assets, liabilities and net worth (SALN).
On Wednesday, the President said: "I don't have a copy (of my SALN) with me. I might give you a wrong figure and end up being questioned by you."
He added: "When it comes to SALN—and I admit I took up only one accounting subject—I might not be able to give you the exact figure down to the decimal point and that might become your headline for two weeks."
"If I have a copy with me, I can read it to you completely, down to the last centavo," he said.
Sole owner
Mr. Aquino said his net worth grew in 2011 because he finally got his inheritance from his late parents, which included sole ownership of the famous Aquino residence on Times Street in Quezon City.
"There is an increase (in net worth) and the increase primarily is because of the inheritance that I got from both my father and my mother which was finalized in 2011," he said.
Mr. Aquino came here to inaugurate a new state-of-the-art radar tower station of the Philippine Atmospheric, Geophysical and Astronomical Services Administration (Pagasa) and lead the ceremonial switch-on of two hydroelectric power plants.
Bequeathed by sisters
The 51-year-old bachelor said the "major" increase in his net worth came from the Times Street residence.
"My sisters have decided to bequeath their portions to me also. So whereas last year, I owned a portion, a share of one out of five, now it's five-fifths. The entirety is my property and my responsibility," he said.
The President's sisters are Ballsy Aquino-Cruz, Pinky Aquino-Abellada, Viel Aquino-Dee and Kris Aquino.
Mr. Aquino's net worth of P54.9 million in 2010 reflected a P4.8-million increase from the previous year. The amount represented his share of the proceeds from the sale of a piece of property in Antipolo City that belonged to his mother.
Originally posted at 08:34 pm | Wednesday, May 02, 2012
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Fleer X-Men cards and overall a good week for X-Men comics. Of course, there was a dud. But that comes along with weekly grind. Plus some listener feedback from the Fastball Tweet Nation. Thanks for listening!
Intro/News (0:00), Hunt for Wolverine #1 (5:38), All-New Wolverine #34 (22:08), Exiles #2 (34:29), X-Men Blue #26 (46:45), Fastball Tweets/Outro (55:45)
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'Name That Party': AP Adds a Race Card to the Mix in Prince George's Co. Md. Corruption Story
A couple of NewsBusters posts during the past week — one from yours truly and another courtesy of Ken Shepherd — have pointed to the press's reluctance to identify the Democratic Party affiliations of indicted Prince George's County Executive Jack Johnson (pictured at right) and his also-indicted wife Leslie, who is a County Council member.
Today, the Associated Press's Brian Witte ">kept up the wire service's tradition of either not naming the party of an indicted Democrat or deferring that identification until very late in the report (in the apparent hope that subscribing outlets picking up the story won't use it). Jack Johnson's party affiliation was saved for the 19th paragraph; Witte never identified his wife's party affiliation. Witte further quoted a Republican who commented on the situation in Paragraph 10, and noted that said Republican "ran against Johnson in 2002″ in Paragraph 11, leaving it vague as to whether it was a primary or general election contest.
Finally, Witte gave voice to someone who believes that the Johnsons and ultimately other county officials are being targeted based on their African-American ethnicity — in county where two-thirds of its residents are African-American.
Here are selected paragraphs from Witte's report:
Corruption charges disturb residents in Md. county
In two years, Prince George's County residents have seen a former schools superintendent sent to prison and corruption charges brought against a senior state senator and the county executive and his wife.
The latest case is the stuff of movies or late-night TV jokes: Authorities say County Executive Jack Johnson and his wife were arrested Nov. 12 after he accepted $15,000 from a developer and federal investigators tapping his phone reportedly heard him tell her to flush a $100,000 check down the toilet and hide $79,600 in her bra.
The string of scandals has left residents angry, frustrated and wondering who will be next. Maryland U.S. Attorney Rod Rosenstein described their arrests as "the tip of the iceberg."
… Prince George's, a suburb of Washington, D.C., is the nation's wealthiest majority-black county, according to the census. The county, which has about 834,000 residents, is 66 percent black with a median annual household income of $71,696.
(paragraphs 10 and 11)
… Audrey Scott, a former County Council member who chairs the Maryland Republican Party, said she used to hear about officials expecting developers to go beyond what was required to, say, build a playground or refurbish a senior citizens center.
"There were certain elected officials who felt that developers owed something more – above and beyond what was required in the zoning application process, in the permitting process," said Scott, who ran unsuccessfully for county executive against Johnson in 2002.
(paragraphs 18 and 19)
… Some residents can only shake their heads when asked about the scandal, walking away and muttering words like "depressing" without saying anything more.
Johnson, a Democrat, now comes to work as the county's chief executive near the end of his second term with an electronic monitoring device. His term ends Dec. 6, when he will be succeeded by a Democrat who had twice run against him unsuccessfully.
… Marva Henry, who lived in Prince George's County for 29 years and only recently moved away, said she questions why prosecutors seem to focus on African-American officials. Her husband, Winston, also expressed frustration that prosecutors seem to be focusing more on Prince George's County than other localities. But both said they were angry at Johnson over the allegations.
Well, if the Henrys have evidence that nearby counties also have serious corruption, they ought to present it (and Witte should have demanded they present it) before just putting a race bias charge out there with no support. One of the reason that there may be seem to be a bit of a focus on African-American officials is probably because roughly 2/3 of the County's Council is African-American. The county's Superintendent of Schools and about 2/3 of the Board of Education are also African-American. All other things being equal, the odds are that if corruption is occurring in Prince George's County, there will be a good chance that African-Americans are involved, and racism on the part of investigators and/or prosecutors has nothing to do with it.
You can't make this up: The county web site's "welcome" page still features a message from the indicted Johnson, and another page contains a glowing bio of Johnson, which includes this sentence:
Mr. Johnson has transformed Prince George's County into Gorgeous Prince George's.
At this point, that assertion is highly debatable at best, and sick joke at worst.
Cross-posted at NewsBusters.org.


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The atypical cadherin FAT4 has established roles in regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The recent identification of FAT4 mutations in Hennekam syndrome, features of which include lymphedema, lymphangiectasia and mental retardation, uncovered an important role for FAT4 in the lymphatic vasculature. Hennekam syndrome is also caused by mutations in CCBE1 and ADAMTS3, encoding a matrix protein and protease, respectively, that regulate activity of the key pro-lymphangiogenic VEGF-C/VEGFR3 signaling axis by facilitating the proteolytic cleavage and activation of VEGF-C. The fact that FAT4, CCBE1 and ADAMTS3 mutations underlie Hennekam syndrome suggested that all three genes might function in a common pathway. We identified FAT4 as a target gene of GATA2, a key transcriptional regulator of lymphatic vascular development and in particular, lymphatic vessel valve development. Here, we demonstrate that FAT4 functions in a lymphatic endothelial cell autonomous manner to control cell polarity in response to flow and is required for lymphatic vessel morphogenesis throughout development. Our data reveal a crucial role for FAT4 in lymphangiogenesis and shed light on the mechanistic basis by which FAT4 mutations underlie a human lymphedema syndrome.
Kelly L. Betterman, Drew L. Sutton, Genevieve A. Secker, Jan Kazenwadel, Anna Oszmiana, Lillian Lim, Naoyuki Miura, Lydia Sorokin, Benjamin M. Hogan, Mark L. Kahn, Helen McNeill, Natasha L. Harvey
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1. Consequent SMC hyperplasia led to progressive medial degeneration and TAAD. In addition to diminished contractile and synthetic functions, fate-mapped SMCs displayed increased proteolysis, endocytosis, phagocytosis, and lysosomal clearance of extracellular matrix and apoptotic cells. SMCs acquired a limited repertoire of macrophage markers and functions via biogenesis of degradative organelles through an mTOR/β-catenin/MITF–dependent pathway, but were distinguishable from conventional macrophages by an absence of hematopoietic lineage markers and certain immune effectors even in the context of hyperlipidemia. Similar mTOR activation and induction of a degradative SMC phenotype in a model of mild TAAD due to Fbn1 mutation greatly worsened disease with near-uniform lethality. The finding of increased lysosomal markers in medial SMCs from clinical TAAD specimens with hyperplasia and matrix degradation further supports the concept that proliferation of degradative SMCs within the media causes aortic disease, thus identifying mTOR-dependent phenotypic modulation as a therapeutic target for combating TAAD.
Guangxin Li, Mo Wang, Alexander W. Caulk, Nicholas A. Cilfone, Sharvari Gujja, Lingfeng Qin, Pei-Yu Chen, Zehua Chen, Sameh Yousef, Yang Jiao, Changshun He, Bo Jiang, Arina Korneva, Matthew R. Bersi, Guilin Wang, Xinran Liu, Sameet Mehta, Arnar Geirsson, Jeffrey R. Gulcher, Thomas W. Chittenden, Michael Simons, Jay D. Humphrey, George Tellides
Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Whilst neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we reported that vascular permeability enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the blood stream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labelling method we provided direct evidence for the systemic dissemination of rTEM neutrophils, showed them to exhibit an activated phenotype and capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrated that increased microvascular leakage reverses the localisation of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to re-enter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.
Charlotte Owen-Woods, Régis Joulia, Anna Barkaway, Loïc Rolas, Bin Ma, Astrid Fee Nottebaum, Kenton P. Arkill, Monja Stein, Tamara Girbl, Matthew Golding, David O. Bates, Dietmar Vestweber, Mathieu-Benoit Voisin, Sussan Nourshargh
Cantu Syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) KATP channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abnormalities. There is currently no targeted therapy, and it is unknown whether cardiovascular features can be reversed once manifest. Using combined transgenic and pharmacological approaches in a knock-in mouse model of CS, we have shown that reversal of vascular and cardiac phenotypes can be achieved (1) by genetic downregulation of KATP channel activity specifically in VSM, and (2) by chronic administration of the clinically-used KATP channel inhibitor, glibenclamide. These findings demonstrate (i) that VSM KATP channel GoF underlies CS cardiac enlargement, (ii) reversibility of CS-associated abnormalities and (iii) evidence of in vivo efficacy of glibenclamide as a therapeutic agent in CS.
Conor McClenaghan, Yan Huang, Zihan Yan, Theresa Harter, Carmen M. Halabi, Rod Chalk, Attila Kovacs, Gijs van Haaften, Maria S. Remedi, Colin G. Nichols
Fibronectin–splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with decreased Akt1/mTOR signaling. Targeting Fn-EDA in human aortic SMCs suppressed the synthetic phenotype and downregulated Akt1/mTOR signaling. These results reveal that SMC-derived Fn-EDA potentiates phenotypic switching in human and mouse aortic SMCs and neointimal hyperplasia in the mouse. We suggest that targeting Fn-EDA could be explored as a potential therapeutic strategy to reduce neointimal hyperplasia.
Manish Jain, Nirav Dhanesha, Prakash Doddapattar, Mehul R. Chorawala, Manasa K. Nayak, Anne Cornelissen, Liang Guo, Aloke V. Finn, Steven R. Lentz, Anil K. Chauhan
Background: Ceramides are sphingolipids that play causative roles in diabetes and heart disease, with their serum levels measured clinically as biomarkers of cardiovascular disease (CVD). Methods: We performed targeted lipidomics on serum samples of individuals with familial coronary artery disease (CAD) (n = 462) and population-based controls (n = 212) to explore the relationship between serum sphingolipids and CAD, employing unbiased machine learning to identify sphingolipid species positively associated with CAD. Results: Nearly every sphingolipid measured (n = 30 of 32) was significantly elevated in subjects with CAD compared with population controls. We generated a novel Sphingolipid Inclusive CAD risk score, termed SIC, that demarcates CAD patients independently and more effectively than conventional clinical CVD biomarkers including LDL-cholesterol and serum triglycerides. This new metric comprises several minor lipids which likely serve as measures of flux through the ceramide biosynthesis pathway, rather than the abundant deleterious ceramide species that are incorporated in other ceramide-based scores. Conclusion: This study validates serum ceramides as candidate biomarkers of cardiovascular disease and suggests that comprehensive sphingolipid panels be considered as measures of CVD.
Annelise M. Poss, J. Alan Maschek, James E. Cox, Benedikt J. Hauner, Paul N. Hopkins, Steven C. Hunt, William L. Holland, Scott A. Summers, Mary C. Playdon
Deep venous thrombosis (DVT) and secondary pulmonary embolism cause approximately 100,000 deaths per year in the United States. Physical immobility is the most significant risk factor for DVT, but a molecular and cellular basis for this link has not been defined. We found that the endothelial cells surrounding the venous valve, where DVTs originate, express high levels of FOXC2 and PROX1, transcription factors known to be activated by oscillatory shear stress. The perivalvular venous endothelial cells exhibited a powerful antithrombotic phenotype characterized by low levels of the prothrombotic proteins vWF, P-selectin, and ICAM1 and high levels of the antithrombotic proteins thrombomodulin (THBD), endothelial protein C receptor (EPCR), and tissue factor pathway inhibitor (TFPI). The perivalvular antithrombotic phenotype was lost following genetic deletion of FOXC2 or femoral artery ligation to reduce venous flow in mice, and at the site of origin of human DVT associated with fatal pulmonary embolism. Oscillatory blood flow was detected at perivalvular sites in human veins following muscular activity, but not in the immobile state or after activation of an intermittent compression device designed to prevent DVT. These findings support a mechanism of DVT pathogenesis in which loss of muscular activity results in loss of oscillatory shear–dependent transcriptional and antithrombotic phenotypes in perivalvular venous endothelial cells, and suggest that prevention of DVT and pulmonary embolism may be improved by mechanical devices specifically designed to restore perivalvular oscillatory flow.
John D. Welsh, Mark H. Hoofnagle, Sharika Bamezai, Michael Oxendine, Lillian Lim, Joshua D. Hall, Jisheng Yang, Susan Schultz, James Douglas Engel, Tsutomu Kume, Guillermo Oliver, Juan M. Jimenez, Mark L. Kahn
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although the underlying molecular mechanisms remain under investigation. Here we demonstrated that endothelial genetic deletion, using EphA4f/f/Tie2-Cre and EphA4f/f/VeCahderin-CreERT2 mice and vessel painting strategies, implicated EphA4 receptor tyrosine kinase as a major suppressor of pial collateral remodeling, CBF and functional recovery following permanent middle cerebral artery occlusion. Pial collateral remodeling is limited by the cross talk between EphA4-Tie2 signaling in vascular endothelial cells, which is mediated through p-Akt regulation. Furthermore, peptide inhibition of EphA4 resulted in acceleration of the pial arteriogenic response. Our findings demonstrate EphA4 is a negative regulator of Tie2 receptor signaling which limits pial collateral arteriogenesis following cerebrovascular occlusion. Therapeutic targeting of EphA4 and/or Tie2 represents an attractive new strategy for improving collateral function, neural tissue health and functional recovery following ischemic stroke.
Benjamin Okyere, William A. Mills III, Xia Wang, Michael Chen, Jiang Chen, Amanda Hazy, Yun Qian, John B. Matson, Michelle H. Theus
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1-ENG-Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K-Akt-mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine-kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus plus nintedanib prevented vascular pathology in the oral mucosa, lungs, and liver of the BMP9/10ib mice, as well as significantly reduced gastrointestinal bleeding and anemia in inducible ALK1-deficient adult mice. Mechanistically, in vivo in BMP9/10ib mouse ECs, sirolimus and nintedanib blocked the overactivation of mTOR and VEGFR2, respectively. Furthermore, we found that sirolimus activated ALK2-mediated Smad1/5/8 signaling in primary ECs—including in HHT patient blood outgrowth ECs—and partially rescued Smad1/5/8 activity in vivo in BMP9/10ib mouse ECs. These data demonstrate that the combined correction of endothelial Smad1/5/8, mTOR, and VEGFR2 pathways opposes HHT pathogenesis. Repurposing of sirolimus plus nintedanib might provide therapeutic benefit in HHT patients.
Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K. Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N. Metz, S. Paul Oh, Lionel Blanc, Fabien Campagne, Philippe Marambaud
Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-alpha 1 chain of collagen III. Loss of structural integrity of the extracellular matrix is believed to drive the signs and symptoms of this condition, including spontaneous arterial dissection and/or rupture, the major cause of mortality. We created two mouse models of vEDS that carry heterozygous mutations in Col3a1 that encode glycine substitutions analogous to those found in patients, and showed that signaling abnormalities in the PLC/IP3/PKC/ERK pathway (phospholipase C/inositol 1,4,5-triphosphate/protein kinase C/extracellular signal-regulated kinase) are major mediators of vascular pathology.Treatment with pharmacologic inhibitors of ERK1/2 or PKC-beta prevented death due to spontaneous aortic rupture. Additionally, we found that pregnancy- and puberty-associated accentuation of vascular risk, also seen in vEDS patients, is rescued by attenuation of oxytocin and androgen signaling, respectively. Taken together, our results provide evidence that targetable signaling abnormalities contribute to the pathogenesis of vEDS, highlighting unanticipated therapeutic opportunities.
Caitlin J. Bowen, Juan Francisco Calderón Giadrosic, Zachary Burger, Graham Rykiel, Elaine C. Davis, Mark R. Helmers, Kelly Benke, Elena Gallo MacFarlane, Harry C. Dietz


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Friday, October 23, 2020 at 4:00 PM until 4:45 PMEastern Daylight Time
Courtyard Marriott Philadelphia City Avenue4100 Presidential BlvdPhiladelphia, PA 19131United States
We are thrilled that you are interested in meeting with an Admissions Counselor.
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We are required to collect the contact information of each guest in accordance with CDC/DOH for contract tracing purposes.


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Book Description
A daring covert action by the CIA to hijack a Boeing 777 passenger plane carrying Russian and Chinese computer scientists to London from Bangkok. These scientists were collaborating on a project to develop a highly sensitive software that could hack computer systems in the USA and bring all activities under their control. As part of the operation, the entire plane with all the passengers, including the scientists, were hijacked and transported to an isolated island in the Indian Ocean, which was serving as a strategic naval base of the USA. Here the scientists were separated from the other passengers and sent to a secret location in the USA in different military aircrafts.The scientists were interrogated and coerced into working for the USA. They were given all facilities needed to develop the program and implement it on the computer systems in Moscow. A startling story of how the program, which was prepared to paralyze the American computer network, was used, instead, to cause a breakdown of the power system in Moscow. Meanwhile, all international efforts to track the Boeing 777 plane proved futile and it was believed to have crashed in the ocean leaving no survivors. The American government also joined the search effort, officially and offered condolences for the "death" of the passengers.