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Inspired by the legendary Michael Jordan, Air Jordan by Nike is undoubtedly the most popular sneaker series of all time. The Nike Air Jordan 4 (IV) (BRED) was first released in 1989, at the time when Michael Jordan was at the peak of his career. Designed by Tinker Hatfield, the Air Jordan 4 combined several new and old design concepts from previous releases.
Key Features/Appearance
For instance, the Air Jordan 4 introduced side straps for increased ankle support. The J IV also borrowed the air sole heel first seen on the Air Jordan 3. The initial color scheme was designed to pay homage to the Bulls' away team colors and it was hugely popular. The Nike Retro re-issue of the Air Jordan 4 was no different; it gave the fans a real chance of getting their hands on a piece of the team's history.
The Retro design features the original colorway, visible Air, ankle straps, as well as a premium synthetic and a mesh upper. Playing in these retros gives a nostalgic feeling; it's comfortable and definitely top-notch. This amazing shoe can be a great addition to your retro collection. Any sneakerhead out there can attest to the fact that the Nike Air Jordan 4 (BRED) is one of the best retros Nike has ever released.
How to Wear Your Air Jordan IV
Even if you rock an awesome pair of Nikes such as the Air Jordan 4, it doesn't make much difference to your appearance if you don't know how to wear it. We'll share a few key pointers to help you get the most out your investment. For starters, don't let your pants drape over or cover your kicks — don't wear sneakers with baggy jeans. Get a good pair of slim jeans to wear with the sneakers and tuck them into the shoes to show your kicks. Also, don't wear kicks with formal clothing.


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Watch Iggy Pop sing 'Tonight' in honor of his friend David Bowie
Iggy Pop paid tribute to his friend, David Bowie, at Carnegie Hall's Tibet House Benefit on Monday night.
The rock star performed "Tonight," a song Bowie wrote that appeared on Pop's 1977 album Lust for Life and, later, on Bowie's own album, Tonight. (Bowie performed the song as a duet with Tina Turner.)
Onstage, Pop was joined by Sharon Jones and harpist Lavinia Meijer.
"It's a wonderful, elegant song with a deceptively simple lyric," he said. "And I think it's the right lyric for right now and for tonight."
Iggy Pop also covered Bowie's "Jean Jeanie" with the Patti Smith Group.

subset: commoncrawl


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Monday-finish Number Theory
Tuesday-Sequences and Series
Wednesday-Just The Facts of Algebra
Thursday-Linear Equations
Friday-Quadratic Equations
Monday-finish Number Theory
Tuesday-Sequences and Series
Wednesday-Just The Facts of Algebra
Thursday-Linear Equations
Friday-Quadratic Equations
Monday-Dilations and Similarity
Dilations & Similar Triangles Rectangles
Tuesday-Midsegment Theorem and Triangle Proportionality
Triangle Midsegment Thm & Proportional Parts (2)
Wednesday-Proving Triangles Similar
Proportions with Similarity – Basic Practice
Proportions with Similarity CW
Day 1 – Practice – Punchline B – Trig Ratios
Friday-Using Trig to find sides and angles
Day 2 – Find Missing Parts Homework
Monday-Practice Test (bring your 2016 SAT Prep book)
Tuesday-SAT Introduction; The New SAT
Wednesday-Weird problems; timing of problems; USA Test Prep-create an account if you have not already
Thursday-Just the Facts-Numbers and Operations
just the facts-numbers and operations 1
just the facts- numbers and operations 2
Friday-Divisibility and Factors
Monday-Proving Triangles Congruent by SSS and SAS
Tuesday-Proving Triangles Congruent by ASA and AAS
Wednesday-Triangle Proofs
day 9 – proving triangles congruent notes
Day 9 – Triangle Proofs Homework
Parallel, Triangles and Transf Review
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Tag archive for g-class configurator
Mercedes-Benz G 350 d: Test Drive with the Diesel G-Class
Until now, the new Mercedes-Benz G-Class was only available as G 500 or AMG G 63. Now Mercedes introduces the G 350 d, the first diesel version of theContinue Reading→
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What Realtor® isn't constantly on the go? Few things have become more beneficial to Realtors® than a smart phone to help you work and prospect while you are out and about.
Luckily for savvy agents like you, there are many great apps designed with Realtors® in mind — emphasis on many. Rather than having you wade through app stores, we've created a two-part roundup with the 10 must-have apps every Realtor® should have. In this first installment, we'll cover apps to aid in your marketing and business efforts. In part two, we'll share apps that can help you manage your showings.
Cloze is beloved by professionals across industries, but Realtors® especially love this app. We've written before about why all agents should have a customer-relationship management (CRM) tool. If you have yet to take the plunge, or want an easy-to-use option when you're out and about, Cloze is perfect for you. Cloze lets you create profiles of your customers and document the details that are important to you, such as your meeting history or what their needs are as a prospective buyer/seller. Plus, you can add photographs and reminders to keep your relationship with clients fresh and valuable. There's no reason nurturing your leads needs to be a daunting process!
Free, with premium options. Available for Android and iOS
Need to create a quick Instagram or Facebook post, but won't be at your computer for a while? Use Canva! Canva is an easy-to-use design tool that lets you build beautiful graphics in just a few clicks. Share an inspirational quote or add some decorative elements to a listing photograph. Canva is free and includes hundreds of templates created by professional designers. You can publish and share straight to your social media profiles.
Free. Available for Android and iOS.
If you really want to knock the socks off of your followers and clients, you can take your social media posts up a notch and create videos! We've written about the effectiveness of video marketing before. You might remember these staggering stats:
• 85% of buyers and sellers want to work with an agent who uses video.
• Homes listed with video get 4X the inquiries of homes listed without video.
• Including video in emails doubles the click-through rate and reduces opt-outs by 75%.
If that doesn't convince you, Animoto's interface will. Upload some clips or images you want to use and pop them into a simple and attractive template. Add text or music and bam! You're done! This is a great resource for quickly making compelling listing presentations.
Free. Available for Android and iOS.
Tracking expenses can be tedious, but it's important for Realtors® to keep their finances in tip-top shape. Expensify makes this process a breeze. Track your purchases and document your receipts in the app. You might still dread tax season (don't we all?) but at least you'll be organized. Plus, this app provides a nice user experience and a good bird's eye view of your business's financial health.
Free. Available for Android and iOS.
Advanced Producer
Our brand-new app was specifically designed for agents like you. We spent months researching what resources Realtors® need most and made that the focus of the app. Advanced Producer provides a library of training guides tested and used by the pros. We work with Realtors® every day to get their feedback and all the content is produced by our innovative and cutting-edge marketing team. Not only that, but you can quickly apply for commission advances on the go. It's free, so check it out today!
Free. Available for Android and iOS.


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In the distribution of
surplus, the takaful company should prioritize the interests of takaful
participants as essentially the surplus is belonging them. When it comes to
issues of surplus, the distribution of the surplus must be carried out fairly
and transparent.
In implementing surplus administrative
process, the following factors need to be considered and taken into account:
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Unrealized profits
The surplus is distributed on income and actual realized profit. This
mean the future participants will get more benefit than the previous generation
of participants as unrealized capital gains are not reflected in previous
surplus distributions.
Provision for bad investment
In takaful industry, provision for bad investment
which value has fallen from the value reflected on the purchase will reduce the
takaful surplus. Therefore, takaful company should rewrite corresponding to
that particular provisions to ensure it benefits the future participants.
Qardhal Hasan
The repayment of the loan, known as Qardhal Hasan should be given priority
over the distribution of surplus to the participants. This is because Qardhal
Hasan is considered as a loan injection into the takaful fund.
Determination of a fund-based
surplus or product portfolio
While there
is a practical limitation to filter out surpluses to individual participants,
efforts must be made to distribute surpluses in a way that identifies the
particular experience of a cohort of participants who share the same
The surplus distribution
process needs to identify those who qualify for the surplus sharing. Among the
eligible participants are as follows:
a. takaful participants who have
never made a claim throughout the year.
b. takaful participants who claim
less than their risk contribution is paid into the risk pool.
takaful participants who have made maximum claims are definitely not


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Live, Play and Work
Fox and Bell has teamed with Fiteni Homes and between them they have an interest in 238 Ha of land previously included in the southern Redland Bay investigation area (the total area is 310 ha) which they propose to develop into an urban village called Shoreline.
This site is one of the few remaining waterfront development sites in SE Qld and so provides a rare opportunity to create a world's best practice urban village in the unique Redlands style.
Fox and Bell's vision builds on new urbanist planning principles combining the built form with open space, job creation, community and transport links. Redlands is not Sydney or the Gold Coast and it demands its own style of solution.
Their proposal would create a $2 billion urban village of 10,000 people around a new mixed-use town centre with all social and civic functions fronting 2.2 km of waterfront devoted to a people's foreshore park.
In line with their view that people should be able to not only live and play, but work in Redlands, the development will in conjunction with Redlands Business Park create 3,600 new jobs for Redland City.
All the infrastructure required for this development, including open space, sporting facilities, medical and schools, will be provided by the developer or others at no cost to the city.
You can read more about this proposal at www.ShorelineRedlands.com.au.


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Last month, a little gold folding bike from the '70's was donated to EBC. The CCM Traveler was in rough shape, but the shiny gold paint under all the dirt and car stickers looked promising, so I decided to clean it up and give it a makeover to create a quirky sweet bike like my own Porta-Bike.
The wheels needed replacing, so I salvaged a set of purple rims and white tires that were too sexy for the kids' bike they were on. Add some white pedals, a white saddle and overhaul most of the bearings, and an uber-cool one-of-a-kind bike was born.
It didn't take long for Goldy Foldy to sell, and it's been at its new home for a while now, but, hopefully, Porta-Bike will get a chance to go for a ride with the Goldy Foldy again.


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For the clearest distillation of Israeli political thinking there is no better place to start than at the top. Haaretz's Barak Ravid reports on Prime Minister Benjamin Netanyahu's message to a meeting of the Knesset Foreign Affairs and Defense Committee:
Prime Minister Benjamin Netanyahu said Monday that although he doesn't want a binational state, "at this time we need to control all of the territory for the foreseeable future."
MKs who took part in the Knesset Foreign Affairs and Defense Committee meeting — where the prime minister spoke — told Haaretz that Netanyahu turned to the politicians and said, hinting at the anniversary of Yitzhak Rabin's assassination: "These days, there is talk about what would happen if this or that person would have remained. It's irrelevant; there are movements here of religion and Islam that have nothing to do with us." Netanyahu then turned to opposition MKs and said: "You think there is a magic wand here, but I disagree. I'm asked if we will forever live by the sword — yes."
There you have it. Israel has every intention to control all of the territory from the Jordan River to the Mediterranean Sea even with the acknowledgement that this means it will "forever live by the sword," meaning endless conflict and bloodshed.


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Sunday night at Glastonbury offers hundreds of ways for weary festival-goers to bow out from Worthy Farm for another year, but the Other Stage gave two distinct options: a shameless, feelgood pop party from Ellie Goulding, and a moody lingering goodbye from Massive Attack.
Goulding's live show has transformed since last summer. Formerly the vaguely hip, breathy electronic vocalist, Goulding has now brought a rockier edge to her stage persona, (along with a gold bra) after a stadium tour earlier this year. At first, her writhing and posturing felt hammy, like a poor man's Tina Turner or Sasha Fierce, it was hair-ography rather than genuine feeling. But as a fiery sunset spread over Worthy Farm, Goulding's facade broke as she launched into Anything Could Happen. Between the cracks we saw a small but bright promise of a big name pop star. Brits Critics' Choice winner Sam Smith could learn a thing or two from Goulding. On Sunday afternoon his pedestrian stage behaviour let down his impeccable vocals. With Dolly Parton entertaining the Pyramid Stage at the same time, there really wasn't any contest.
After Goulding's mini-me fans fled to see Disclosure at West Holts, Massive Attack arrived with their pulsing bass and primal beats, juddering the fan-filled field into a head-nodding stupor. Underfoot the mud was as gloopy as ganache and the scent of burning joss stick and weed floated through the air. At times the Bristolian trip-hop group, now in their 26th year, could be accused of self-indulgence, but there were moments of beauty during this instrumental dubfest too. During Teardrop a white flare shot up above the stage, gently floating down to the ground as Horace Andy broke into Angel.
The Park Stage was a perfect Pilton setting for Yoko Ono. The 81-year-old's calls to change the world fit right in with the enormous "Save Glasto from fracking" banners held up by her crowd, which included a woman wearing an amazingly mud-free kimono and a bearded Dolly lookalike. Backed up by cult indie rockers Yo La Tengo, Ono whooped and yelled into the microphone with a power that belied her tiny frame.
Endearingly, she worked her way through her set with the aid of a laminated songbook on a music stand, which she referred to when she wasn't dancing or sharing wisdom-tinged anecdotes. Ono encouraged patience: "some things take time in life – you know we did the bed in. That still hasn't changed that much." It was sage advice: after the inevitable wait to get out of the car parks tomorrow, this year's attendees will have to pass another 12 months before being able to do it all over again.


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「Catching potential bombers obviously is a good thing, but there are ways to do it without making news operations look like government shills,」 USA Today said in an editorial today. 「When journalists contact potential sources — whether by phone, e-mail or in person — they need people to trust that they are in fact reporters, not undercover cops.」
「What was wrong about the Seattle operation was the potential damage
to the credibility of the Associated Press by the creation of a false
news account by the government and by the impersonation of a reporter,」 a
argued. 「The technique threatens to undermine all reporters — not just
those from the AP — who seek information from sources and represent
themselves truthfully as independent journalists.」
Reuters media columnist Jack Shafer wrote: 「Whenever police officers masquerade as journalists, they introduce doubt into the public's mind about whether the next person purporting to be a journalist is actually a police officer or the stories in the news are really bait set by police.」
In Pennsylvania, The Scranton Times-Tribune Editorial Board said this: 「Democracy works only with an independent press that is not controlled by the government. The nation's Founding Fathers knew that. That's why, right there in the First Amendment, it says that Congress shall make no law … abridging the freedom of speech, of the press.
「It doesn't include a specific prohibition against government agencies impersonating reporters. Perhaps the founders believed that their successors would have the good sense not to jeopardize the independence of the press.
「Recently, however, the FBI has decided to impersonate the press, thus diminishing the press』 separation from the government.」
In an opposing view published by USA Today, former FBI Assistant Director Ronald T. Hosko, now president of the Law Enforcement Legal Defense Fund, said the FBI 「takes seriously its use of sensitive operations,」 adding that in the Seattle investigation 「no law was broken, no policy was avoided, nothing was traded away with an 『ends justify the means』 calculus.」
Meanwhile, AP is awaiting a reply to President and CEO Gary Pruitt's Nov. 10 letter to Attorney General Eric Holder and FBI Director James Comey in which he asked who authorized the investigative tactics in 2007 and sought 「assurances that this won't happen again.」
Editorials also have appeared in The New York Times, The Denver Post, The Seattle Times, The Arizona Republic, The Spokesman-Review (in Spokane, Washington), The Repository (in Canton, Ohio) and other newspapers.


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With German-born Jochen Hecht and Marco Sturm already established quantities in the NHL, this past season saw Dennis Seidenberg, Christian Erhoff, and Christoph Schubert take their games to a new level. Erhoff was a top-four blueliner for the top regular-season team, the San Jose Sharks. Seidenberg has become a top-four defenseman for the Carolina Hurricanes, contributing considerably to their inspiring playoff run. Schubert continued to carry out the role as a craftsman of all trades for an Ottawa team that struggled throughout the season. As soon as next season, they may be joined by several more German faces, namely Buffalo's 2005 second rounder Philipp Gogulla and 2006 fourth rounder Felix Schutz. Also developing nicely this past season were 2006 draftees and current DELers Korbinian Holzer (TOR, 4th round) and Constantin Braun (LA, 6th round), who faced off against each other in this season's championship series, with Braun's Eisbaren Berlin getting the upper hand. Progress was also made by 2007 draftees Timo Pielmeier (SJ, 3rd round) and Dennis Reul (BOS, 5th round), both of whom spent this past winter playing key roles in the QMJHL for the Shawinigan Cataractes and Lewiston MAINEiacs respectively.
The 2008 NHL Entry Draft only featured one drafted German, Cologne's Jerome Flaake (TOR, 5th round). Making the jump from the junior team to the Germany's top league, Flaake didn't take long to establish himself as a regular and more importantly, a player with great potential.
As was the case last summer, there are several prospects playing in Germany who have clocked in among the CSS' top 200 European players. Here's a look at the top six Germany prospects entering the 2009 NHL Entry Draft in Montreal on June 26-27.
1. Daniel Weiss, F – Shoots: Left – 6'3, 196 lbs.
CSS European Rank #57
Feb 22, 1990
The younger brother of Eisbaren Berlin sensation Alexander Weiss, Daniel spent this past season playing alongside his big brother. In what was in many ways a storybook year, Daniel made the Eisbaren Berlin and by the end of the season, was regularly killing penalties with Alexander in the DEL finals. Along the way, he put up six goals, five assists, 55 penalty minutes and a +2 rating for the DEL champions in 52 total games. He also added two goals and seven points in eight games with the B team, the Eisbaren Juniors in Germany's third league.
Weiss has caught the scouts' attention by displaying a propensity to play the body well and showing strong puck-protection skills. His good hockey sense and generally strong skating helps him get by despite needing to work on his first two steps. Nonetheless, he adjusted extremely well to the speed of the DEL. His increase in development was placed on display internationally for Team Germany at the U20 tournament in Canada. Despite it being a tough tournament for Germany, Weiss tied for second in team scoring with two goals, four points and a +3 rating in six games. The confidence gained there was carried over to finish off the DEL season. With a contract until 2011 in his pocket, management expects Weiss to continue to develop and ultimately excel in establishing himself as a top player in the DEL as soon as next season.
2. Thomas Brandl, C – Shoots: Left – 5'11, 176 lbs.
CSS European Rank #75
Feb 8, 1991
The younger brother of former Prince Albert Raiders forward Max Brandl, Thomas Brandl split this past season with his hometown Landshut Cannibals of the German second league and their DNL (junior) team. Brandl became an integral part of the second league team's checking line, chipping in with four goals and six points while racking up 28 penalty minutes. Brandl was a key offensive contributor for the junior club, scoring 13 goals and 23 points in 17 games and then adding six goals and 13 points in nine playoff games. The Landshut juniors made a surprising run to the finals, where they were easily dismissed by the favored team from Mannheim. Diminutive in size, Brandl is anything but diminutive in heart, bringing with him an aggressive style of play while also being considered highly coachable.
After an injury-plagued 2007-08 season, the constant load of playing regularly for two teams plus an international tournament has him in the finest shape of his young career. This was evident at the U18 tournament in April, when Brandl led Team Germany with four assists and scored one goal, a game winner, in what was a disappointing tournament for Germany. Unfortunately, his usually strong defensive play couldn't prevent him from ending the tournament with a -3 rating. In addition, his face-off abilities will need some fine-tuning, but his technical adeptness is above-average, so he should improve in this category along the way. Brandl is the son and namesake of long-time German National Team member Thomas Brandl and jumped from a CSS mid-season rank of 99 among Europeans to his current No. 75 ranking. Depending on the Canadian junior league import draft, Brandl may make the jump to North America next season. Otherwise, he'll spend next season becoming an even more important building block for his Landshut Cannibals.
3. Kevin Puschnik, F – Shoots: Left – 5'10, 165 lbs.
CSS European Rank #76
Sept 2, 1991
Having spent the 2008-09 season with the Mannheim Juniors in the DNL, the undersized Puschnik is ranked 76th among European skaters, third among Germany players. Puschnik put up 36 goals and 60 assists in 44 total regular season and playoff games, leading the DNL's top team in scoring while playing with linemate Marc El-Sayed. This total also proved to be one of the most impressive totals ever in the young DNL's history. Intriguing however, is that he possesses Austrian citizenship and is the son of one of Austria's most famous national ice hockey players, Gerhard Puschnik. As such, he suited up for Austria at the Division I, Group B U18 championship in Denmark, having led Austria in scoring with four goals and four assists in five games. Despite his solid contributions, Austria only managed to finish third out of six teams.
A crafty player with an excellent ability to read the game, the mite-sized Puschnik is also one of the youngest players in the 2009 draft. Quick on his feet, Puschnik regularly displays the ability to know when he should shoot and when he should pass. Still, at his size, he'll need a lot of work on his physical game if he's to make it into one of world's better leagues, much less the NHL. There's no argument however, that he has his sights set on the best league in the world. As for next season, Puschnik very much hopes to follow fellow countrymen Stefan Ulmer and Michael Grabner, both of whom have made names for themselves with excellent seasons for Spokane of the WHL. Should he not be drafted by a CHL club in the 2009 import draft, he may very well look to join a team in the USHL and perhaps set his sights on NCAA hockey, a route once taken by Thomas Vanek.
4. Laurin Braun, F – Shoots: Left – 5'11, 180 lbs.
CSS European Rank #109
Feb 18, 1991
The younger brother of Los Angeles 2006 sixth rounder Constantin Braun, Laurin spent this past season in his brother's organization playing for the Eisbaren Juniors. There he put up 14 goals, 18 assists and 59 penalty minutes in 47 games after having put up a point per game in 24 games the season before. Unlike his older brother, Laurin doesn't feature a hulking frame, coming in a good four inches shorter than his brother, but he made a huge jump in the maturity department this year. His play during the course of the season ultimately earned him a cup of coffee with the big club, having seen moderate ice time in a three-game introduction. A strong skater, Laurin has good offensive instincts but will simply have to get stronger if he wants to one day play a regular role in the DEL, much less at a higher level. Like Weiss, Braun was chosen to play for Team Germany at the U18 tournament and didn't disappoint, putting up two goals and four points in six games. His -1 rating tied him for second on the team in that department (only Marcel Ohmann registered a plus rating with +1 in five games). Laurin will be looking to earn himself a regular role in the DEL line-up next season, something his drafted older brother has successfully done over the course of the past two seasons.
5. Marc El-Sayed, F – Shoots: Left – 6'3, 212 lbs.
CSS European Rank #126
Jan 18, 1991
In the 2008-09 season, the well-built El-Sayed helped lead his Mannheim/Heilbronn Juniors to the DNL championship, dismissing challenger Landshut in quick fashion, 4-1 and 9-4 in the best-of-three series. In 33 regular season games, El-Sayed contributed a whopping 17 goals, 33 assists and 28 penalty minutes to the league's runaway top team. The pace didn't drop off in the playoffs, where he finished second in playoff scoring with six goals and 19 points in eight games. Making this achievement all the more impressive is that it coincided with his semi-regular play for the Heilbronn Falcons of Germany's second league. Used sparingly, El-Sayed failed to get even one point in 20 total games with the Falcons, but after totaling six penalty minutes in 17 regular season games, he oddly amassed 27 penalty minutes in only three playoff games in a heated first-round dismissal at the hands of the surprising Lausitzer Foxes.
As one of the better-sized participants, El-Sayed represented Team Germany at the U18 tournament. Like many of his teammates, he had hard time preventing the team from being relegated, going -5 in six games. He did however lead the team in scoring with three goals and three assists while managing to stay out of the penalty box completely. Where his path will take him next season has yet to be determined. He'll likely find himself taking on a bigger role in Germany's second league while working on his speed and his overall game. Then again, El-Sayed's combination of size and playmaking ability may even be tempting enough to see him get drafted by a Canadian junior team in the import draft.
6. Dominik Bielke, D – Shoots: Left – 6'3, 190 lbs.
CSS European Rank #134
Oct 23, 1990
Although only ranked fifth among German prospects entering this draft, Bielke took some huge steps this past winter. Playing for the Eisbaren Berlin's second team, the Eisbaren Juniors, Bielke had a huge season for a surprisingly competitive team in Germany's third professional league, where he was also named the third best defenseman in the league by Germany's top ice hockey publication, the Eishockey News. Playing in 47 games for the juniors, Bielke scored 14 goals, 39 points and racked up 104 penalty minutes. His play earned him a call-up to the big team and he didn't disappoint, getting one assist and putting up a +2 rating in seven DEL games. The German national program made quick note of the rising star, giving him ample ice time at the U20 tournament in Canada. In six games, Bielke gathered four penalty minutes and a rough -4 rating.
Particularly impressive are Bielke's offensive instincts as a blueliner. He possesses a hard, accurate shot and skates very well for a boy his size. His offense came at a consistent rate this past season, even if he wasn't able to translate that aspect of his play in Germany to the U20 tournament. According to management, Bielke must work on his first few steps, but is surely knocking very loudly on the DEL team's door. As such, some of the defensemen currently playing for the senior team will have keep an eye on their jobs, as Bielke's summer training will go a long way in determining just how much of an impact he can make at the top level next season – his offensive instincts are already very enticing to management and the coaching staff.
The remaining two Germans ranked by CSS for the 2009 NHL Entry Draft are:
Marco Nowak, D – Shoots: Right – 6'1, 198 lbs.
Dusseldorf, DEL
CSS European Skater Rank #200
Felix Bruckmann, G – 5'11, 169 lbs.
Heilbronn, German third league
CSS European Goalie Rank #13
DNL = Deutsche Nachwuchs Liga (German Young Prospects League)


text: The Living Bridges of Mawsynram. 06/06/2019 By Derwombat In the wettest place on Earth, the village of Mawsynram in Meghalaya, India are some of the most fascinating bridges you'll ever see. These "living bridges" are formed by locals who have trained the roots of rubber trees to grow into natural bridges. They are sturdy enough to far outlast man-made wooden structure bridges. Because of the relentless rain in Meghalaya's jungles, wooden structures would rot away. These root bridges are self-strengthening, becoming more sturdy over time as the root systems grow. Photographer Amos Chapple captured these shots of people crossing these bridges that have developed over the years. Notice the school children nonchalantly walking on a bridge over a river as well as a local guide taking a trip over a developing tree root bridge. To manipulate the rubber trees into bridges and ladders, they must create tight knots that can withstand Meghalaya's rain-soaked environment. As Chapple explains about the process, "The skeleton of the bridge is bamboo, with tendrils from the surrounding rubber trees are being fixed onto the structure strand by strand. By the time the bamboo has rotted away, within 6-8 years, locals say the roots of the tree will be able to bear a person's weight." via India's Fascinating Tree Root Bridges Grow Stronger Every Year – My Modern Met. Share this:Click to share on Pocket (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)MoreClick to share on Reddit (Opens in new window)Like this:Like Loading... Related About Derwombat My name is Rod Parham, Hot Metal Compositor. I was born in Adelaide, South Australia in 1947. Single with two children and a grandson. I Love History, Movies and Words.


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March 12, 2018
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England boss Eddie Jones has insisted he was pleased to see his side struggle at times during their victory over Samoa.
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text:
In Klingon, there's an animal toqvIr lung translated as "Tokvirian skink".
I thought that was a made-up word, but apparently, there really are animals called "skinks". Huh!
(And they're lizards, which makes sense, given that lung "loong" is described as a lizard-like animal. I presume the name was influenced by the Chinese word 龍 lóng for a dragon.)


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This is a simple but delicious chicken and eggplant bake. Serve with a variety of your favourite steamed vegetables.
Here is how to improve the taste of eggplant. Slice it up, then sprinkle salt generously on each side. Set your slices in a bowl or collander. Leave it for about 20 minutes. The eggplant will be covered in "sweat", because it is sweating out the bitterness. Rinse off your eggplant, and cook accordingly. Yes the water that comes off will be sort of brown. This will make the eggplant taste better and will eliminate the unnecessary step of boiling, which will make the eggplant mushy. - 25 Oct 2002 (Review from Allrecipes USA and Canada)
Holy Smokes!!! This was so good and so easy I can hardly believe it!! I did change the way I sweat the eggplants though. I salt them and place them in a colander for 30 minutes with a heavy bowl on top of the eggplant. Then I rinsed off all the extra salt. I think letting them sit in water would make them too mushy. Other than that...loved this recipe and will make it again. I served this with rice (for my husband) and he loved it as well. - 06 Jul 2005 (Review from Allrecipes USA and Canada)
Great dish if you know what you are doing! I am beginner to cooking with eggplant so I took advice from everyone, sweat the eggplant in a colander,marinated the chicken in balsamic,lemon juice and olive oil and I layered it with ricotta. I think I overdid the cayenne and salt. Anyway wasn't bad for my first try, I topped with an Italian five cheese blend, we eat cheese by the pound at my house so I knew that would go over well. Next time I will get black olives to use in it. I agree use lots of spice. - 24 Jan 2006 (Review from Allrecipes USA and Canada)


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On-line version ISSN 1414-431X
Braz J Med Biol Res vol.45 no.6 Ribeirão Preto June 2012 Epub Mar 15, 2012
Braz J Med Biol Res, June 2012, Volume 45(6) 488-496
Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom
J. Saturnino-Oliveira2,4*, M.A. Tomaz1*, T.F. Fonseca1, G.A. Gaban1, M. Monteiro-Machado1, M.A. Strauch1, B.L. Cons1, S. Calil-Elias3, A.M.B. Martinez2 and P.A. Melo1
1Programa de Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
2Programa de Ciências Morfológicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
3Departamento de Farmácia e Administração Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brasil
4Departamento de Morfologia, Universidade Federal de Sergipe, Aracaju, SE, Brasil
Material and Methods
Correspondence and Footnotes
We studied the effect of pulsed ultrasound therapy (UST) and antibothropic polyvalent antivenom (PAV) on the regeneration of mouse extensor digitorum longus muscle following damage by Bothrops jararacussu venom. Animals (Swiss male and female mice weighing 25.0 ± 5.0 g; 5 animals per group) received a perimuscular injection of venom (1 mg/kg) and treatment with UST was started 1 h later (1 min/day, 3 MHz, 0.3 W/cm2, pulsed mode). Three and 28 days after injection, muscles were dissected and processed for light microscopy. The venom caused complete degeneration of muscle fibers. UST alone and combined with PAV (1.0 mL/kg) partially protected these fibers, whereas muscles receiving no treatment showed disorganized fascicules and fibers with reduced diameter. Treatment with UST and PAV decreased the effects of the venom on creatine kinase content and motor activity (approximately 75 and 48%, respectively). Sonication of the venom solution immediately before application decreased the in vivo and ex vivo myotoxic activities (approximately 60 and 50%, respectively). The present data show that UST counteracts some effects of B. jararacussu venom, causing structural and functional improvement of the regenerated muscle after venom injury.
Key words: Pulsed therapeutic ultrasound; Bothrops snake venom; Myotoxicity; Mouse skeletal-muscle regeneration
Muscle damage can be induced by many agents, e.g., extreme physical activity, trauma, specific disease states, chemical offenders, or the aging process (1). In tropical countries, a neglected cause of muscle damage is snakebite (2). The envenomation induces local effects such as acute edema, hemorrhage and myonecrosis, due to complex actions of various toxins present in the crude venoms (3). In severe cases, these local effects can lead to drastic sequelae such as permanent tissue loss, disability, or even amputation (4). Venoms of the genus Bothrops have been extensively studied under different protocols (5). Particularly, the venom of Bothrops jararacussu causes local myonecrosis due to the presence of components with proteolytic and phospholipase activities (6-10). Phospholipases present in B. jararacussu venom include two myotoxins: bothropstoxin I (Lys49 phospholipase A2, PLA2), which lacks enzymatic activity, and bothropstoxin II (Asp49 PLA2), which has catalytic activity (7,11,12). The exact mechanism of myonecrosis induced by PLA2 is not fully understood, but its pathogenesis has several features in common with myonecrosis induced by other types of muscle damage: plasma membrane depolarization and disruption, sarcoplasmic reticulum retraction, clumped myofibrils, mitochondrial edema and rupture, and nucleus pyknosis (11,13-16).
The currently available treatment for envenomation with B. jararacussu venom is the administration of antibothropic polyvalent antivenom (PAV), which has low and limited effectiveness against myotoxic activity (9,10,12). PAV may prevent death, but does not prevent local tissue damage and subsequent functional disabilities (17). Researchers have been seeking alternative treatments that could antagonize such local effects, increasing tissue recovery and hastening the patient's return to daily routine (18-23).
Therapeutic ultrasound has been shown to induce biological activities related to tissue recovery, such as stimulation of collagen synthesis (24), activation of fibroblasts (25), increased blood flow (26), synthesis and/or release of growth factors and satellite cell activation, proliferation, and differentiation (27-29). Rather than continuous ultrasound with its heating effect, the pulsed mode has been used for muscle regeneration (30,31). Delivered in pulsed, nonthermal settings, ultrasound can result in therapeutic effects through mechanical mechanisms, such as cavitation and acoustic streaming (32). In the present study, we determined if ultrasound would improve skeletal muscle regeneration following envenomation. We examined the effect of pulsed ultrasound therapy (UST) on mice following perimuscular injection of crude B. jararacussu venom.
B. jararacussu venom and the antibothropic PAV were provided by Instituto Vital Brazil, Rio de Janeiro, Brazil. This polyvalent antivenom is prepared from immunized horse serum, with B. alternatus, B. cotiara, B. jararaca, B. jararacussu, B. moojeni, B. neuwieddi, and B. pradoi; 1.0 mL antivenom neutralizes 2.5 mg venom. The diagnostic kit used to determine creatine kinase (CK) activity was purchased from Bioclin-Brazil. All other reagents were of analytical grade. The ultrasound device used was the SONOCEL dual from BIOSET Industry of Electronics Technology (Brazil). The rotarod was purchased from AVS Special Projects (Brazil).
Adult male and female Swiss mice (25.0 ± 5.0 g) were used. All the protocols were approved by the Ethics Committee on the Use of Animals of the Federal University of Rio de Janeiro.
Experimental protocols
Mice were divided into four groups of 4-6 animals. They were anesthetized with ethyl-ether and then injected with crude venom (1.0 mg/kg in saline by applying 50 µL of the solution to the extensor digitorum longus (EDL) muscle of the right limb (EDL perimuscular injection, in order to prevent direct mechanical damage to the muscle), as described previously (9,10,33). All groups except the first, which was used as an untreated positive control, were treated 1 h after venom injection with UST under the following conditions: 1 min/day, frequency of 3 MHz, intensity of 0.3 W/cm2, pulsed mode, 20% duty cycle (2 ms on, 8 ms off), pulse frequency of 100 Hz. The effective radiating area was 1 cm2. To couple the ultrasound device to the mouse limb we used aqueous gel, with minimum pressure to maintain contact. One group received the same ultrasound treatment as the other groups, plus one intravenous injection of PAV (1.0 mL/kg) 15 min after venom injection. The negative control group received an injection of saline in the right limb.
Measurement of muscle total CK content
The total CK content of EDL muscle was measured in all animal groups. Mice were anesthetized with ethyl ether and killed by cervical dislocation 1, 3, 7, and 28 days after injection of 1.0 mg/kg venom. EDL muscles were dissected, freed from fat and tendons, dried and weighed. The muscles were then homogenized in 2 mL saline/0.1% albumin, CK content was determined and reported as units per gram muscle tissue (U/g) (34).
Histological examination
Three and 28 days after perimuscular EDL injection of 1.0 mg/kg venom, the mice were anesthetized with ethyl ether and killed by cervical dislocation. The EDL muscles were dissected and fixed overnight in 2.5% glutaraldehyde and 4% paraformaldehyde in 0.1 M sodium cacodylate buffer, pH 7.4. Next, they were washed three times in the same buffer and postfixed for 1 h in 1% OsO4. The tissue was then dehydrated in increasing acetone concentrations (30-100%) and embedded in Polybed 812 resin. Sections (500 nm) for light microscopy examination were obtained using an RMC ultramicrotome, stained with 1% toluidine blue, and then observed and photographed under light microscopy. Some mice injected with 1.0 mg/kg B. jararacussu venom were killed after 24 h and their EDL muscles were isolated, fixed in standard paraformaldehyde, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (HE).
Edematogenic activity
Five minutes after venom injection (0.1, 0.3, 1.0, and 3.0 mg/kg), the animals received ultrasound treatment. The negative control group received only the injection of saline in the right limb. Measurements were made at 0, 15, 30, 60, and 90 min after venom injection or ultrasound treatment. An analog caliper was used to measure the mediolateral and anteroposterior widths of the paw, and the product of these values is reported as mm2.
Leukocyte counts
Two groups of four mice each received a perimuscular EDL injection of 1.0 mg/kg B. jararacussu venom. Five minutes after venom injection, one group received an ultrasound application according to the protocol. Blood was collected by periorbital puncture before the injections and 2 and 24 h after them. Total and differential leukocyte counting was performed. A 10-μL aliquot of blood was used to determine the total leukocyte count. Residual red blood cells were lysed by adding Turk's solution. For cytological examination, preparations were stained with May-Grunwald-Giemsa stain. Cell differentiation was performed by counting 100 cells, which were classified as lymphocytes, neutrophils or monocytes based on normal morphological criteria.
Motor functional activity: rotarod test
Motor activity was assessed using the rotarod test to analyze the riding time as previously described (35). The mice were trained daily for a period of 120 s for 5 days on the rotating cylinder (8 rpm). One, 3, 7, and 28 days after injection of 1.0 mg/kg venom alone or with treatments, the animals were submitted to the rotarod test and the time spent by the animal on the apparatus was recorded. UST was applied each day to the treatment groups, including a first application 5 min after venom injection. Each animal underwent three trials, and the mean time spent on the rod was determined for each group.
In vivo and ex vivo B. jararacussu myotoxic activities
The myotoxicity of B. jararacussu venom was studied both in vivo and ex vivo on the basis of CK activity. The ex vivo analysis employed observation of the rate of CK release from isolated mouse EDL muscle bathed in a solution containing the venom (25 µg/mL). Four EDL muscles were mounted vertically in a cylindrical chamber and superfused continuously with Ringer's solution equilibrated with 95% O2/5% CO2. At 30-60-min intervals, the solution perfusing the muscles was collected and replaced with fresh solution. The collected samples were used for the measurement of CK activity. Muscles were weighed at the end of the experiment. Enzyme activity is reported as international units corrected for muscle mass, where 1 U is the amount that catalyzes the transformation of 1 µM substrate at 25°C (36,37). The fresh solution for bathing the muscles contained either normal B. jararacussu venom or the venom solution after being sonicated with therapeutic ultrasound for 1 min at the same settings used so far, in order to observe the direct effect of ultrasound on venom myotoxic activity.
For the in vivo studies, 4 mice were injected with 50 µL venom (1.0 mg/kg), im, into the right thigh. Previous studies have shown that intramuscular injection of 0.1 mL saline has no effect on plasma CK levels (36,37). Two hours after injection, the mice were anesthetized with ethyl ether for collection of blood samples (50-100 µL) by orbital puncture. The plasma was separated by centrifugation and used for determination of CK activity. In vivo myotoxic activity was also observed with sonicated venom.
The proteins present in the crude B. jararacussu venom were examined by electrophoresis after the venom was sonicated for 1 or 2 min. Polyacrylamide gel (12%) electrophoresis in the presence of 0.1% sodium dodecyl sulfate (SDS-PAGE) was performed according to the standard method of Laemmli (38), and the proteins were stained with 0.1% Coomassie brilliant blue.
Statistical analysis
Data were analyzed statistically by the Student t-test; ANOVA was used for repeated measures and the Tukey test was used for group comparisons. Data are reported as means ± SEM. Differences were considered to be statistically significant when P < 0.05.
Functional activity and edematogenic effect of the venom
After B. jararacussu venom injection, all animals, including those receiving UST, showed a decrease in functional ability to stand on the rotarod. However, on the first and third day after injection, mice receiving venom only or venom + PAV showed a more pronounced decrease compared to animals treated with UST or UST + PAV. This result shows that UST decreased the impact of venom on motor functional activity. On the seventh day, all animals were able to remain on the rod for as long a time as the control mice, showing recovered function (Figure 1).
The venom induced dose-dependent edema (Figure 2A), reaching a peak within 15 min with lower doses, and after about 60 min with the highest dose. When applied 5 min after 1.0 mg/kg venom administration, UST decreased the edematogenic effect, suggesting that reduced edema can improve the motor function of mice receiving UST (Figure 2B).
Changes in CK content
Damage to the sarcolemma, allowing CK to leave the cell, was marked, so that CK content inside the cell dropped substantially after perimuscular venom injection (Figure 3). This effect was reversed by UST. One day after venom injection, EDL CK content was 41.05% of the CK content observed in the group receiving only saline. The treatments with UST, PAV and PAV + UST reduced the drop in CK content induced by the action of the venom (Figure 3A). On the third day, the CK content was reduced to nearly 33% in the venom group, PAV did not decrease the effect of the venom, while the treatments with UST and UST + PAV did protect the muscle from CK loss (Figure 3B). The CK content was restored in the treated groups 7 days after venom injection, but the untreated group recovered only partially (52.6% of control) (Figure 3C). Twenty-eight days after venom injection and treatments, all groups had a CK content similar to that of the control group (Figure 3D).
Histological results
Twenty-four hours after perimuscular injection of B. jararacussu venom, the longitudinal section of HE-stained EDL muscle showed an intense inflammatory infiltrate and myofibers in the process of necrosis (Figure 4). Figure 5 shows light micrographs of EDL muscle 3 days after venom injection and treatments (N = 5 per group). In the muscles that received saline injection and UST we observed a typical structural organization of skeletal muscle (Figure 5A and B), showing that UST does not damage muscle cells. Animals receiving only venom showed degenerated peripheral cells (Figure 5C). Treatment with UST partially protected the cells from the action of the venom because the damaged area was smaller than in the venom group (Figure 5D). Muscles treated with PAV combined with UST showed a normal profile, indicating protection from venom, while PAV alone was ineffective (Figure 5E and F).
Twenty-eight days after injection, all the animals (venom only and treatments) had EDL muscle profiles resembling the architecture of the control group (Figure 6). Peripheral cells were arranged in fascicles, showing regenerated cells with their characteristic centralized nuclei (Figure 6D).
Changes in leukocyte counts
Venom induced a marked decrease in total leukocyte count 2 h after injection (Figure 7A). The leukocyte levels returned to the same range as that of the saline-injected group after 24 h. UST prevented the total leukocyte count from decreasing. Figure 7B shows the differential leukocyte counts. The proportion of neutrophils increased after venom injection, an event that, again, was prevented by UST.
In vivo and ex vivo CK activity
B. jararacussu venom induced an increase in CK activity, both ex vivo (from 1.47 ± 0.38 to 40.01 ± 1.85 U·g-1·h-1 after 90 min of exposure) and in vivo (from 81.73 ± 22.14 to 1808.98 ± 285.15 U/L) compared to control conditions, which consisted of exposure to saline (Figure 8A and B, respectively). Interestingly, application of UST directly to the venom solution prior to exposure caused a smaller increase in ex vivo (from 1.47 ± 0.38 to 27.60 ± 2.75 U·g-1·h-1) and in vivo (from 81.73 ± 22.14 to 967.31 ± 71.15 U/L) CK activity compared to venom without ultrasound application, suggesting a direct effect on the toxins present in the crude venom. Surprisingly, the analysis of the protein profiles of the crude venom, assessed by SDS-PAGE electrophoresis, showed no effect of ultrasound on the protein contents (Figure 8C).
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We have shown that pulsed UST could ameliorate the damaging effects of B. jararacussu venom, from edema to myonecrosis, including motor dysfunction, in mice. Treatment with UST reduced the functional and edematogenic activity of the venom, while PAV did not. In parallel to decreasing edema and improving motor activity, UST was able to counteract the considerable drop in EDL CK content, as well as protecting peripheral fibers from necrosis. Therefore, mice receiving treatment with UST showed better muscle performance, i.e., because the morphological and biochemical properties seemed to be preserved, their physical activity was superior to that achieved by untreated animals. Although in morphological analysis we did not measure the extent of the damaged area or the number of centrally located nuclei, this qualitative demonstration of the positive effects of ultrasound was confirmed quantitatively by CK content and rotarod performance. The evaluation of PAV alone confirmed previous data showing it to be of limited effectiveness against myonecrosis induced by B. jararacussu venom (17). On the other hand, if applied in combination with UST, PAV seems to be of value.
Adult skeletal muscle is a notably stable tissue and has a remarkable ability for self-repair when damaged, irrespective of the underlying cause of damage. However, the regeneration process can be relatively slow, which obviously delays the return of human patients to their normal activity. Thus, research has been directed to discover ways to both improve and accelerate the process of muscle recovery.
Therapeutic ultrasound has been shown to affect a range of cellular activities that together contribute to hasten and enhance functional rehabilitation. Although therapeutic ultrasound is known for its heating capacity in deep tissues, it may have other effects on tissues that are not related to heat generation (39). Johns (32) proposed a molecular mechanism whereby the mechanical properties of pulsed ultrasound interact with molecular (and multimolecular) complexes within the cell, thereby modulating membrane properties, cell metabolism and synthesis of substances, specifically the activation of proteins and signal-transduction pathways, which may result in modifications of cellular function. Since these nonthermal effects of therapeutic ultrasound have been implicated in tissue regeneration, the pulsed mode has received great attention from researchers in this field (30,31).
The observation in both ex vivo and in vivo analyses that direct sonication could decrease myotoxicity was surprising, suggesting that it could degrade protein in the venom. However, SDS-PAGE electrophoresis of the venom revealed that proteins present in the normal venom solution were still present in the solutions receiving UST, even when the duration of application was doubled. A possible explanation could be that ultrasound directly applied to the venom could disturb any active site of proteins that contribute to the myotoxic action of the venom, without changing the protein primary structure, which is responsible for the molecular weight. The frequency resonance hypothesis for the nonthermal effects of therapeutic ultrasound has been proposed (32). This hypothesis suggests that the mechanical energy within the US wave is absorbed by proteins, altering the 3-D structural conformation of an individual protein or the function of a multimolecular complex. Further studies will be necessary to clarify the specific effect of ultrasound on the properties of the toxins.
Overall, our data suggest that pulsed ultrasound therapy can be useful in the management of skeletal muscle injury following B. jararacussu snake bite. Adding pulsed ultrasound therapy to the therapeutic arsenal against snake bites could contribute to hastening recovery, either by preventing venom action or improving recovery, or both. Prevention of the actions of the venom can be due to the resonance hypothesis regarding proteins, described above, or it can result from anti-inflammatory effects of pulsed ultrasound. Improved recovery could come from one or more of the therapeutic ultrasound properties shown earlier in this section.
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17. da Silva NM, Arruda EZ, Murakami YL, Moraes RA, El-Kik CZ, Tomaz MA, et al. Evaluation of three Brazilian antivenom ability to antagonize myonecrosis and hemorrhage induced by Bothrops snake venoms in a mouse model. Toxicon 2007; 50: 196-205. [ Links ]
18. Melo PA, Homsi-Brandeburgo MI, Giglio JR, Suarez-Kurtz G. Antagonism of the myotoxic effects of Bothrops jararacussu venom and bothropstoxin by polyanions. Toxicon 1993; 31: 285-291. [ Links ]
19. Melo PA, do Nascimento MC, Mors WB, Suarez-Kurtz G. Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents. Toxicon 1994; 32: 595-603. [ Links ]
20. da Silva AJM, Melo PA, Silva NM, Brito FV, Buarque CD, de Souza DV, et al. Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. Bioorg Med Chem Lett 2001; 11: 283-286. [ Links ]
21. da Silva AJ, Coelho AL, Simas AB, Moraes RA, Pinheiro DA, Fernandes FF, et al. Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom. Bioorg Med Chem Lett 2004; 14: 431-435. [ Links ]
22. Arruda EZ, Silva NM, Moraes RA, Melo PA. Effect of suramin on myotoxicity of some crotalid snake venoms. Braz J Med Biol Res 2002; 35: 723-726. [ Links ]
23. Murakami MT, Lourenzoni MR, Arruda EZ, Tomaz MA, Vicoti MM, Abrego JR, et al. Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom. Protein Pept Lett 2008; 15: 1002-1008. [ Links ]
24. Webster DF, Harvey W, Dyson M, Pond JB. The role of ultrasound-induced cavitation in the 'in vitro' stimulation of collagen synthesis in human fibroblasts. Ultrasonics 1980; 18: 33-37.
25. da Cunha A, Parizotto NA, Vidal Bde C. The effect of therapeutic ultrasound on repair of the achilles tendon (tendo calcaneus) of the rat. Ultrasound Med Biol 2001; 27: 1691-1696. [ Links ]
26. Noble JG, Lee V, Griffith-Noble F. Therapeutic ultrasound: the effects upon cutaneous blood flow in humans. Ultrasound Med Biol 2007; 33: 279-285. [ Links ]
27. Rantanen J, Thorsson O, Wollmer P, Hurme T, Kalimo H. Effects of therapeutic ultrasound on the regeneration of skeletal myofibers after experimental muscle injury. Am J Sports Med 1999; 27: 54-59. [ Links ]
28. Karnes JL, Burton HW. Continuous therapeutic ultrasound accelerates repair of contraction-induced skeletal muscle damage in rats. Arch Phys Med Rehabil 2002; 83: 1-4. [ Links ]
29. Piedade MC, Galhardo MS, Battlehner CN, Ferreira MA, Caldini EG, de Toledo OM. Effect of ultrasound therapy on the repair of gastrocnemius muscle injury in rats. Ultrasonics 2008; 48: 403-411. [ Links ]
30. Freitas TP, Gomes M, Fraga DB, Freitas LS, Rezin GT, Santos PM, et al. Effect of therapeutic pulsed ultrasound on lipoperoxidation and fibrogenesis in an animal model of wound healing. J Surg Res 2010; 161: 168-171. [ Links ]
31. Wu S, Kawahara Y, Manabe T, Ogawa K, Matsumoto M, Sasaki A, et al. Low-intensity pulsed ultrasound accelerates osteoblast differentiation and promotes bone formation in an osteoporosis rat model. Pathobiology 2009; 76: 99-107. [ Links ]
32. Johns LD. Nonthermal effects of therapeutic ultrasound: the frequency resonance hypothesis. J Athl Train 2002; 37: 293-299. [ Links ]
33. Melo PA, Ownby CL. Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins. Toxicon 1999; 37: 199-215. [ Links ]
34. Melo PA, Ownby CL. Different sensitivity of fast- and slow-twitch muscles to some snake venoms and myotoxins. Toxicon 1996; 34: 653-669. [ Links ]
35. Ko MH, Chen WP, Lin-Shiau SY, Hsieh ST. Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function. Exp Neurol 1999; 158: 37-46. [ Links ]
36. Melo PA, Suarez-Kurtz G. Release of creatine kinase from skeletal muscles by Bothrops venoms: heparin potentiation of inhibition by antivenin. Braz J Med Biol Res 1988; 21: 545-548. [ Links ]
37. Melo PA, Suarez-Kurtz G. Release of sarcoplasmic enzymes from skeletal muscle by Bothrops jararacussu venom: antagonism by heparin and by the serum of South American marsupials. Toxicon 1988; 26: 87-95. [ Links ]
38. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685. [ Links ]
39. ter Haar G. Therapeutic applications of ultrasound. Prog Biophys Mol Biol 2007; 93: 111-129. [ Links ]
Research supported by FAPERJ, CNPq, CAPES, Fundação Universitária José Bonifácio (FUJB, UFRJ), and PRONEX.
Address for correspondence: P.A. Melo, Laboratório de Farmacologia das Toxinas, ICB, CCS, Universidade Federal do Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, Brasil. Fax: +55-21-2610-3726. E-mail: firstname.lastname@example.com
*These authors contributed equally to this study. Received September 28, 2011. Accepted February 17, 2012. Available online March 16, 2012. Published June 4, 2012.
The Brazilian Journal of Medical and Biological Research is partially financed by
|All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License


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stock repurchase plan
Situation when a company purchases its own stock. In the US, the UK and some other countries, a corporation can distribute cash to existing shareholders to repurchase its own stuck for a fraction of the outstanding equity of the company. US corporate law provides five methods of stock repurchase: private negotiations, open market, repurchase put rights, fixed price tender offer and Dutch auctions.


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|Jun Sun <firstname.lastname@example.com>
|Re: busybox does not like 2.4.8, or the other way around?
|Karsten Merker <firstname.lastname@example.com>
|Fri, 21 Sep 2001 07:30:07 +0200
|<email@example.com>; from email@example.com on Thu, Sep 20, 2001 at 06:21:49PM -0700
|Karsten Merker <email@example.com>, Jun Sun <firstname.lastname@example.com>, firstname.lastname@example.com
On Thu, Sep 20, 2001 at 06:21:49PM -0700, Jun Sun wrote: > I have a small busybox userland that works fine with 2.4.2 kernel, but failed > with the latest 2.4.8 kernel. The symptom is that it is stuck at the > following prompt: [busybox waiting for keypress] > A simple test shows the console is still working, i.e., pressing a key *does* > generate an interrupt and ISR *does* read the correct char value. > > I really cannot think of anything else that might make busybox stuck here. > Any clue? Anybody else is using busybox with more recent kernels? I have a smilar problem on my DECstation. Using 2.4.8 with the Debian boot-floppies (based on busybox), the machine hangs when waiting for the first keypress after the splash screen. When booting 2.4.8 with my "normal" installation into single user mode, I get a shell prompt, but cannot enter anything. I first thought of a problem with the DECstation keyboard driver, but the same happens on serial console. I have tested various kernel version with regard to this - the last one working for me is 2.4.5. When booting my "normal" installation with 2.4.8 into multiuser mode, the machine crashes somewhere in the init scripts. Is your box little or big endian? Greetings, Karsten -- #include <standard_disclaimer> Nach Paragraph 28 Abs. 3 Bundesdatenschutzgesetz widerspreche ich der Nutzung oder Uebermittlung meiner Daten fuer Werbezwecke oder fuer die Markt- oder Meinungsforschung.
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Love startups but don't know skateboarding? You still need to listen to Rodney Mullen
Rodney Mullen will be at this year's Web Summit in Dublin. His presence alone makes the event worth attending – even if it's teasing the idea of leaving Dublin entirely.
Mullen is arguably the greatest skateboarder of all time and his thoughts on creativity and genius will teach you more than a thousand management books. Watch the clip from 'Bones Brigade: An Autobiography' below to see why:
Oh and if you're someone who just gets turned on by cash, think of this – Mullen was the principle investor in World Industries which was sold for $46 million in 2002. He also holds patents for innovative truck designs.
Yeah, it's safe to say I'm a Rodney Mullen fan. You should be too.
Read next: Verizon is offering roadside assistance for older cars at $15 a month


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Coloma United Methodist Church
Consultation Report
Prescription 1 Developing Clear, Vision, Goal Setting and Structure Realignment
● a. yes vote complete
● b. service of prayer, healing, and forgiveness complete
● c. Visioning workshop complete
○ Vision statement: "Compassionate people: seeking, sharing, serving; discovering the love of Jesus, together"
● d. goal setting workshop complete.
○ continue to take prescriptions
○ include one new person per month in the life of the church
○ involve (two or more activities) one new person per month
● e. Ministry audit team has completed their work.
○ recommendations
■ discontinue participation in the Parish Nurse program through Lakeland Medical. Action taken effective June 30, 2015.
■ discontinue 'sponsoring church' relationship with Lighthouse Ministries of Benton Harbor. In discussion
■ design pilot programs to augment existing service programs to make them more relational. In discussion
● f. Job descriptions done
● g. Moving to governance model of organization
○ a. study of book "Winning of Purpose" completed
○ b. governance model workshop scheduled for Sept 8, 2015, 6:30pm
○ c. implementation of new governance model by fall 2015
■ First phase completed January 1, 2015 to separate existing council into two mutually accountable bodies :
Vision and Ministry, and Operations. Vision and Ministry Team to consist of 6 Ministry Teams: Worship,Hospitality, Missions,
Communications, Congregational Development, and Congregational Care.
■ Second phase establishment of new Church Council to take effect January 1, 2016. Leadership Development Team beginning work
to recruit council representatives.
a compassionate people, seeking, serving, sharing, discovering the love of Jesus, together.


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There is something you should know about Uncle Pete…
He's a bit of a messy feeder.
So, after breakfast, when he was getting the ACN changed, some food fell out of her jammie pants.
His reaction of, "Dude… butt toast?" made her laugh.
The Monkey's family went to a funeral Saturday morning, so she came over to hang out with The ACN.
At first this involved a lot of playing Webkinz online and making fun of Uncle Pete.
And then lots of giggling.
Eventually, the Monkey couldn't keep the music inside and just had to start singing.
In French.
My gentle reminder that "We sing in English in this family!!!!" only caused her to raise the decibel level about 50 points and incorporate some dance moves.
She strutted and danced around The ACN in chair-y. The ACN squealed, laughed and sang some back-up.
The ACN wouldn't let me throw The Monkey out.
I asked more than once.
My continued complaints about the French music eventually worked. She stopped.
For three seconds.
Then she launched into Rhianna's "Unfaithful."
She sang EVERY SINGLE WORD.
I asked The ACN if The Monkey was a good singer.
Then The Monkey sang "Life is a Highway." Despite the fact that it was released five years before she was born, she also sang every word. And she worked in some of her got-to air guitar moves.
Because, as she recently told me, "You can never have too much air guitar, Peter."
She completed her three song set with Aerosmith's "Don't Wanna Miss A Thing." There was much emoting and every time she sang "you" she stopped and pointed at me.
That kid is loony.


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Product details
On an average day, you can find roughly 83% of Boden staffers wearing something stripy. Well, nothing beats a classic. This long-sleeved Breton is made from supersoft cotton and is THE wardrobe must-have.
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Your cart is emptyDiscover our novelties
The luminosity of Baccarat's Clear crystal figure is crafted into two figures melded into a single columnar shape, representing the ever-unbreakable bond between mother and child.
The nativity of Jesus Christ is depicted as portrait of maternal love, with Saint Mary lovingly holding her baby. The beauty of the Baccarat Clear crystal imbues this statuette with mysticism and spirituality. Moreover, the lucidity of the crystal symbolically represents the clarity of sacred and divine love. The detail in the facial features and the pleating of the robe illustrates the finery of Baccarat's craftsmanship. A perfect gift for the holidays, this figurine pays tribute to holy Biblical mythology and the sacred nature of familial love.
Our Baccarat advisers will give you a personalized welcome and will be delighted to accompany you as you discover the House of Baccarat and its products.
Monday to Friday. 9am - 5pm EST


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Le Mill Coupons 2017
Le Mill India is an e-commerce store that offers products in various categories like home furnishing, decor & apparels. Le Mill is home to some of the most iconic fashion brands and renowned designers – Balenciaga, Alaïa, Isabel Marant, Alexander Wang, Mary Katrantzou, Stella McCartney and more. Each piece is carefully curated, and each brand carries a singular sartorial identity. Use latest Le Mill coupons and deals to save money while shopping.
Active Coupons
1 offer
success 100%
Apparel & accessories: upto 40% off
Click to open site
Sale: upto 40% off on apparel & accessories listed on the landing page. No coupon code is required.
- April 12, 2014
Unreliable Coupons
some of them might still work


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I went to visit this new restaurant from Mr reggae reggae Levi Roots. The venue has a decent vibe to it, reggae style music in teh background and a cool …
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You have until September 3 to vote for all your favorites in Southern Minnesota. If you want to make your voice heard and vote for Mark Allen as Best Solo Act or just go support all the talent and exceptional businesses, follow (cut and paste) this link http://www.southernminnscene.com/category/best-of-scene-2018/#/gallery?group=287687
Mark Allen Upcoming Shows and News!
Saturday, September 1 – guest of Relativity at the Cannon River Winery 2-5 Sunday, September 2 – toe tappin' tunes at Captain's Lakeside Grill, Isanti, MN. Music 2-5 Friday, September 7 – Private Party Saturday, September 8 – guest of Relativity at the Marina Lodge in Fairmont, MN. Music 7-11
Mark Allen – Cannon River Winery, Cannon Falls, MN – Sunday, August 26 @ 2pm
Mark Allen – Faribault West Mall Anniversary Party! Thursday, August 16 @ 5pm
Mark Allen – The Marina Lodge, Fairmont, MN
From Northern Minnesota on Friday to Southern Minnesota on Saturday! Mark is on a cross-MN trip and landing at the Marina Lodge on Saturday, May 13 and taking the stage at 7:30pm. Stop by and listen in to all your favorite songs including Mark Allen's original music! Come early and stay late. http://www.themarinalodge.com/


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Is this meta-marketing? Sony dropped a press release today to announce their new marketing effort for the PS3. Unsurprisingly the campaign is based on the triad of the new $400 40GB PS3, Blu-ray support, and the new PS3 game titles hitting stores for the holidays. Somewhat surprising though is an added focus on PlayStation Network and the forthcoming PlayStation Home functionality.
The press release:
Nov 2, 2007 16:49 ET
Sony Computer Entertainment America Unveils New PLAYSTATION(R)3 Advertising Campaign
Television Campaign Timed to Launch New $399 PS3(TM)
FOSTER CITY, Calif., Nov. 2 /PRNewswire/ — Sony Computer Entertainment America (SCEA) today announced a brand new advertising campaign for PLAYSTATION(R)3 (PS3(TM)) that will include both television and online elements. The new campaign, delivers a high-energy message with a focus on the exciting entertainment value of PS3 and exclusive content found only on PS3. The lineup of advertisements will feature some of SCEA's most highly anticipated first party titles such as Heavenly Sword, Ratchet & Clank Future: Tools of Destruction, Warhawk, Uncharted: Drake's Fortune and Gran Turismo 5 Prologue, along with upcoming third-party exclusives like Haze from Ubisoft and Metal Gear Solid 4: Guns of the Patriots from Konami.
(Logo: http://www.newscom.com/cgi-bin/prnh/20020701/SFM066LOGO)
In addition to the pure game play, the campaign, developed in conjunction with TBWA\Chiat\Day, will convey to consumers the benefits of Blu-ray Disc(TM) (BD) movie capability of PS3. Also for the first time, sharp focus will be paid to PLAYSTATION(R) Network along with breakthrough services such as PLAYSTATION(R)Home.
"We are confident that this new and exciting advertising campaign and our new $399 price point will go a long way in helping to further spark PS3 sales as we head into the ever important holiday buying season," said Peter Dille, senior vice president, marketing and PLAYSTATION Network, SCEA. "With a focus on the great library of software titles coming to PS3, this advertising campaign is a perfect vehicle to get that message across and show the breadth of content that you can only find on PS3."
While the online component of the advertising campaign launched on October 4, one of the many high-profile places the television component will air is during the New England Patriots vs. Indianapolis Colts game at 4:15 pm EST. November 4, 2007. This is also the date that the new 40GB PS3 will make its official debut in retail outlets across the country at a price point of $399. Consumers will see the campaign, made up of both :60 and :30 second spots, on a wide range of network, cable and syndicated television outlets such as the NFL on FOX and CBS, Prison Break (FOX), Conan O'Brien (NBC), Saturday Night Live (NBC), Family Guy (FOX), South Park (Comedy Central), The Daily Show (Comedy Central), SportsCenter (ESPN), NBA and NCAA Basketball (ESPN2), NBA (ESPN), College Football (ESPN2), TRL and The Real World (MTV), WWE (USA), Adult Swim (Spike TV) and UFC Unleashed and Game Head (Spike TV).
The new advertising campaign, which represents the largest campaign to date for PS3, will also feature clips from several other third-party software titles such as Burnout Paradise, WWE SmackDown!, Assassin's Creed, Madden NFL 08 and Time Crisis 4.
About Sony Computer Entertainment America Inc.
Sony Computer Entertainment America Inc. continues to redefine the entertainment lifestyle with its PlayStation(R) and PS one(R) game console, the PlayStation(R)2 computer entertainment system, the PSP(R) (PlayStation(R)Portable) handheld entertainment system, and the ground-breaking PLAYSTATION(R)3 (PS3(TM)) computer entertainment system.
Recognized as the undisputed industry leader, Sony Computer Entertainment America Inc. markets the PlayStation family of products and develops, publishes, markets, and distributes software for the PS one game console, the PlayStation 2 computer entertainment system, the PSP system and the PS3 system for the North American market. Based in Foster City, Calif. Sony Computer Entertainment America, Inc. serves as headquarters for all North American operations and is a wholly owned subsidiary of Sony Computer Entertainment Inc.
"PlayStation" and "PLAYSTATION" and "PS one" are registered trademarks and "PS3″ is a trademark of Sony Computer Entertainment Inc..
Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020701/SFM066LOGO
AP Archive: http://photoarchive.ap.org/
PRN Photo Desk, firstname.lastname@example.com
Source: Sony Computer Entertainment America Inc.
CONTACT: Patrick Seybold of Sony Computer Entertainment America Inc.,
+1-650-655-7549, firstname.lastname@example.com
Web site: http://www.playstation.com/


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Creative Concepting & Design
Once we have developed your in-store shopper marketing strategy, we really get creative!
Armed with the knowledge of what makes your shopper stop, look, sample and buy, we design meaningful and satisfying moments of customer engagement.
Our forward-thinking creative teams combine the freshest in retail marketing design and pop-culture trends with over 50 years of experience in consumer behavior to form effective shopper experience campaigns—engaging customers in-store, online and in the street.


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Have you ever stayed in the office until the wee hours of the morning to hit a deadline without receiving so much as a pat on the back the next morning? Have you ever racked up double digits in overtime hours in a single week without so much as a handshake from your boss?
Recognition matters, and a "thank you" for going the extra mile – or even just for regular day-to-day work – goes a long way toward ensuring employee engagement and retention.
If you want your employees to stay with your company, you need to make them feel engaged. To do that, you must give them regular feedback. That may be difficult for some leaders and managers, but it's well worth it – especially if done the right way.
"Most people feel just as uncomfortable about giving a review as those receiving the review," says Renee Charland, director of human resources for MBH Architects, a San Francisco-based architecture firm that gives biannual employee evaluations that last about a month and a half. "By focusing on what we can improve upon – the future – and providing multiple points of reference, there is less anxiety, less avoidance of issues that need to be improved, and less cognitive bias."
By keeping in such close contact with its workers, MBH is able to address the needs of each employee on a more focused, individual level. Each employee has different needs and struggles in different areas at work. By sitting an employee down and talking to them in-depth, leaders and managers at MBH are able to determine what both the company and the employee can do to improve the worker's productivity and/or address their concerns.
The lengthy review process also helps employees stay focused on their career paths and the steps they need to take to advance with the company.
"Because career development isn't a linear process and is often different for each individual, having a flexible path of increasing responsibility rather than grades or levels has been successful for most [of our] employees," Charland says. "Recent graduates in particular can struggle when they no longer have the structure of advancement academia provides, so accomplishing goals and gaining new experiences gives them a sense of achievement and progression."
The review process is just one part of a positive company culture approach at MBH. Other factors that contribute to the work environment include a nine-square employee progress board, with employees becoming eligible for promotion upon reaching the ninth square; individual and group evaluations; a safe forum where all employees can comment and offer suggestions; and employee surveys focused on positivity and overall improvement.
Stay Positive
Nobody likes a nag, so keeping interactions with employees positive is crucial. If you point out flaws and mistakes in a negative, harassing, or critical way, workers are more likely to go on the defensive and get less out of the process.
In addition, timing can be everything.
"Constructive criticism needs to be provided in real time, not gathered up and sprung on the employee twice a year in their review," Charland says. "By addressing issues as they arise, and generally only needing a small course correction, we can build trust between the supervisor and employee, identify what the issue really is – who remembers six months later? – and quickly get back on track. We also have built up trust between supervisors and HR, as well as employees and HR, so they [supervisors] ask for advice on how to handle those difficult conversations."
The Results
A month-and-a-half review process may seem extreme to many executives, but the results are undeniable. In a company-wide survey, 88 percent of MBH's employees strongly agree or agree that they have the opportunity to learn and grow at work. Additionally, 82 percent feel that they have a strong mentorship relationship that encourages their development.
"The entire process takes a month and a half to complete but isn't the only thing employees are working on, and the various steps are broken up throughout the month and a half so projects still advance," says Charland. "That being said, it is a significant commitment of time, and employees are reminded it is some of the most important time they spend."
If this sort of employee engagement seems over the top, consider your company's turnover rates. Go the extra mile and survey employees to see how satisfied they are in their respective roles. In a corporate world where job hopping is the new norm, can you really afford to be disengaged from your workforce?


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Mazda released pricing on the 2012 Mazda3, which is now available with the automaker's Skyactiv engine. The new power plant will be available in Mazda3 i Touring models, which start at $18,450. "Mazda3 i Touring models swap the MZR engine for the all-new SKYACTIV-G 2.0-liter gasoline engine, and is EPA-rated to achieve 40 mpg on the highway," says Mazda in a press release.
Mazda says that the new engine delivers 21 percent better fuel economy, but that increase doesn't come at the expensive of power. Autoblog writes, "With an Environmental Protection Agency-estimated 40 mpg and 155 horsepower, the engine is both more efficient and more powerful than its predecessor."
There's also good news for shoppers interested in the base model, as Mazda has lowered the price on the Mazda3 i SV to $15,200, not including a $795 destination fee. However, Edmunds reports that the 2012 Mazda3 i Sport sees a $140 price increase to $17,640 (including a $795 destination fee). Both the base i SV and i Sport models carry the 2.0-liter four-cylinder engine from the 2011 model.
Shopping for an affordable small car? Check out the U.S. News rankings of this year's best cars. Then, look for a great deal on a new car by checking out this month's best car deals. Also, be sure to follow us on Twitter and Facebook.


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Prepaid Card Support
At Prepaid we pride ourselves on providing the highest quality customer service 24 hours a day 7 days a week.
Our dedicated teams offer you peace of mind, knowing that you are fully supported at all times.
If you have an issue with your Prepaid Card or any of our services, please visit the Card Support FAQs or online Support Chat within the CardHolder system, or contact our Customer Service team:
Contact Form
If you wish to know more about the Another Prepaid Card Services for you or your business, your enquiry will be passed to the relevant support desk to respond to your request:


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7 dead, 5 injured in container blast in east China
Sunday, 2019-03-31 16:44:38
Seven people have been confirmed dead, and five others injured after an explosion occurred in a container containing scrap metal in a metal molding plant in east China's Jiangsu province Sunday (March 31) morning.
The explosion happened at 7:12 a.m. in an outdoor yard of the Kunshan Waffer Technology Corp. Ltd. in Kunshan Bonded Zone.
The cause of the explosion is still under investigation.
The incident follows a deadly blast on March 21 at a chemical park in the city of Yancheng, also in Jiangsu province, that killed 78 people and wounded hundreds others.


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Pam's Journey
Follow Pam's journey to wellness with Dartmouth-Hitchcock's Weight & Wellness Center. In this video, produced by Dartmouth-Hitchcock's Creative Productions team, Pam describes her challenges with her weight and her commitment to getting healthier. Follow Pam's journey on D-H social media and monthly in Imagine Better eNewsletter.
The Dartmouth-Hitchcock Weight & Wellness Center is committed to providing coordinated health care for patients with obesity, education and outreach to our communities and robust clinical research in the field of obesity. The Weight & Wellness Center's Healthy Living Clinic is a comprehensive, evidence-based program that promotes healthy weights, healthy lifestyles and a reduction of weight-related medical conditions for patients of all ages. The center offers innovative medical, surgical and endoscopic treatments to help patients execute a personalized plan to achieve their health and wellness goals. Learn more about Dartmouth-Hitchcock's Weight & Wellness Center.


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The ALIGN Capability – introduction video
Watch and learn more about ALIGN in our new introduction video.
Watch and learn more about ALIGN in our new introduction video.
ALIGN's experience underscores the philosophy that there are many different approaches to sustaining an acceptable risk level, while at the same time reducing the cost of upgrading, maintaining and replacing safety systems on oil and gas installations.
Watch and learn more about ALIGN in our new introduction video.
We experience a great deal of uncertainty in the market following the announcement of discontinued production of BS100 spare parts. The industry in general seems to have limited knowledge of possible alternatives for maturing BS100 fire & gas systems.
In a time where the focus on cost savings is at its peak, we need to ensure that the safety of the installations still meets the requirements and that we still can claim to be "top of the league" regarding safety in the Petroleum sector.
– When performing cabling operations, many men are needed offshore on the platforms over several days. Bed capacity becomes a challenge.
Origo Solutions has implemented a new shutdown philosophy at Gyda, to the satisfaction of Talisman Energy.
Joint effort across all Align's divisions will ensure one of the most important energy projects for two countries before the end of 2014.