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Connecticut's rain on top of snow has Malloy 'worried'
BRANFORD -- As rain fell onto already heavy rooftops and snowy streets outside the firehouse around him, Gov. Dannel P. Malloy said there were still many concerns as municipalities try to recover from record snowfalls.
Meeting with town officials Monday afternoon and later taking questions from the press, Malloy said the biggest challenge is helping out municipalities that don't have the equipment to handle these historic snowfalls -- adding that the current rainy weather is worrisome and may add more problems.
Most interstates and state routes are open, even if only partially, Malloy said, so state contractors have been released to help out the municipalities.
The rain coming down Monday had Malloy "worried," he said. Drains are still blocked from the snow and the ice freezing over will present more travel problems and heavier rooftops that can lead to collapse.
"Roofs are a big problem. [There's] more rain than we would have liked," he said, adding that when possible people need to try to clean the drains on the roof. "Once this ices up it will be a gigantic problem."
Because so many schools in the state have flat roofs, Malloy said officials are telling superintendents to have maintenance people clear the drains.
"We went through this two year ago with the massive snow accumulation and we're going to pound away at superintendents to make sure their maintenance people are up on those school roofs clearing the drains and then watching the structure itself," Malloy said.
The barriers of snow that line the streets and highways will ice over and become hard like "jersey barriers," Malloy said, urging everyone to drive slowly. Accidents on the roads are completely blocking off streets and highways because there aren't enough lanes of traffic plowed.
In urban areas, like Bridgeport, New Haven and Hartford, there was a lack of space for people to park cars not on the street, which has impeded snow removal. In suburban areas, like Hamden, cul-de-sacs and streets on hills have contributed to snow drifts up to 10 feet tall, Malloy said.
Malloy said municipalities are asking for pay loaders to help with the cleanup.
"... and they're asking for those because you have to pick this stuff up and to get through a 10-foot drift at the bottom of a hill you've got to do more than plow you can't push it out of the way," he said.
The governor said other states have been helping out Connecticut by sending massive snow-blowers.
Malloy said there are 230 Humvees being used in the state right now.
Some have been set up as ambulances, and others are out helping with emergency calls, he said, because getting ambulances to the scene of an emergency is still a problem.
Because of the declaration of a state of emergency, towns can have 75 percent of their storm costs recovered for a 48-hour period. The 48-hour-period they pick is up to the town, Malloy said.
Asked about storm costs, Malloy didn't have a number yet. "It's officially a lot."
Malloy said they are bringing in whatever extra resources they can to help the towns that are overwhelmed.
"This is a historic storm. We had historic levels of snow in every one of our counties, and in urban environments, there's just less places to push it, and the equipment is being overwhelmed so that's why were' bringing in additional resources from other states at this point to help other municipalities," he said. "We've got our state roads by and large clean enough so we released those crews to local government."
Though he said experience with these natural disasters is something he would "rather not necessarily have," the state is "getting good at this."
"We have learned and we are responding better than we would've if this was the first one," he said.
Natural disasters added with the shooting in Newtown has made for a "tough run" he said, but "we're hearty stock here in Connecticut."


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text: 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 GMC Yukon Car Audio Upgrades GMC, formally the GMC Division of General Motors LLC, is an American automobile division of the American manufacturer General Motors that primarily focuses on trucks and utility vehicles. The new GMC Yukon was introduced for 1992, a full-size SUVs from General Motors. Here at HifiSoundConnection.com, we have a full selection of GMC Yukon Car Audio Upgrades and Packages that will suit your car audio needs. These products were made to its finest by the leading names in car audio products today. Feel free to browse at HifiSoundConnection.com and purchase your very own Car Audio Upgrades at its lowest prices ever!


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Happy Friday Parents!!!
As most of you know, we are going on a field trip to see Wonder on December 12! We are so excited! Make sure you sign the permission slip and give your child money for snacks and pop. If your student brings money early, I can hold onto it. However, I would prefer that your student bring it on the field trip day.
On Monday, December 4th, we have our holiday concert. Please have your student to the school no later than 6:45. I will be in my classroom so they will come to my room to wait for the concert to start. Make sure they are dressed in holiday spirit for our class photo!
Today, I will be entering in A LOT of grades, so be on the look out for your child's progress!!
Have a great weekend!


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Nov 21, 2012–Groton, USA (Techreleased) – The U.S Navy has awarded General Dynamics Electric Boat a $61.7 million contract modification for the continued development of the Common Missile Compartment for the United Kingdom's Successor ballistic-missile submarine and the U.S. Ohio replacement submarine. Electric Boat is a wholly owned subsidiary of General Dynamics.
Under the modification, Electric Boat will procure, manufacture and test prototype material and equipment to be used in the production of the Common Missile Compartment.
The award modifies a contract announced in December 2008 for engineering, technical services, concept studies and design of a Common Missile Compartment for the next-generation ballistic missile submarines being developed for the Royal Navy and the U.S. Navy. If all options are exercised and funded, the overall contract would have a value of more than $776 million.
This work will engage Electric Boat's engineering and design organization, which comprises more than 4,000 employees. Possessing proven technical capabilities, these employees work on all facets of the submarine life cycle from concept formulation and design through construction, maintenance and modernization, and eventually to inactivation and disposal.


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SLAS2018 Show Preview: Where the life sciences community converges
January 2018
Society for Laboratory Automation and Screening
SLAS2018 International Conference and Exhibition
February 3-7, 2018
San Diego Convention Center
Where the life sciences community converges
San Diego plays host to this year's International Conference and Exhibition of the Society for Laboratory Automation and Screening
SAN DIEGO—Annual meetings of professional societies are always very interactive affairs, with networking, reuniting and socializing high among the goals in addition to educational sessions. The annual meeting of the Society for Laboratory Automation and Screening (SLAS)—this year's SLAS2018 International Conference and Exhibition—hits that theme of connection and togetherness doubly, though, with not only a show tagline of "Where discovery meets technology" but also a message at the top of the SLAS2018 website home page that reads: "Be where the life sciences community converges—Be in San Diego for SLAS2018."
It's also a theme that carries into a brand new program launching at SLAS2018, called SLAS Ignite, which aims to connect industry and academic researchers on collaborative projects. As the society notes on its annual meeting website of SLAS Ignite, "Life sciences research today is an increasingly collaborative endeavor, with individuals and organizations realizing tremendous benefit by tapping into the experience, insights and capabilities of peers and complementary organizations to develop the medicines and innovations that improve the human condition.
"SLAS is proud to have served as a venue for collaboration since the society's founding. Bringing together a diverse community of engineers, researchers, scientists, business leaders and pioneering academic experts has enabled SLAS members to advance scientific research by using the latest technologies and insights provided by fellow members of the SLAS community."
At SLAS2018, the following presentations have been selected to partake in the inaugural SLAS Ignite Academic Theater (all presentations will take place in the Exhibition Theater on the SLAS2018 Exhibition show floor):
Also new for SLAS2018 is a program for exhibitors: Solutions Spotlight presentations. These 20-minute presentations are for highlighting a new product or customer case study enabled by way of a company's technology, and they will take place in the SLAS2018 Exhibition Theater, which is also making its debut at SLAS2018 in San Diego.
On the educational side of the meeting, there are also several new tracks added: Biologics Discovery, Chemical Biology and High-Definition Biotechnology.
SLAS describes the Biologics Discovery track thus: The success of biologic therapeutics in the clinic has put greater emphasis on earlier stage efforts to increase efficiency, productivity and innovation. This track will emphasize innovative solutions to increase the breadth, depth and impact of early stage efforts to fuel the biologics pipeline. How automation and screening can play a key role in the progression of new therapeutics as well as the impact of novel assays, microfluidics and biorepositories. Planned sessions include:
The following SLAS2018 Short Courses are recommended for those interested in biologics discovery:
The Chemical Biology track will focus on the challenges of addressing targets with small molecules, including validation of targets using tool molecules and proof of target engagement through appropriate biomarker identification. Additionally, this track will cover advances in library design, keeping libraries current and a session will be dedicated to DNA-encoded libraries. Planned sessions include:
The following SLAS2018 Short Courses are recommended by the society for those interested in chemical biology:
As for the High-Definition Biotechnology track, SLAS says: This track focuses on the application of microfluidic, optical and molecular tools in disease biology, diagnostics, screening and translational medicine. The session will emphasize state-of-the-art quantitative high-throughput and high-resolution approaches in both simple cellular systems and complex tissues. These approaches enable multiparametric studies that reveal the interplay of genetics, disease and therapeutic opportunities and move personalized medicine ahead. Topics include the latest specialized engineering and assay technologies, including single-cell and sequencing-based approaches, and cutting-edge application and disease areas including immuno-oncology. Planned sessions include:
The following SLAS2018 Short Courses are recommended for those interested in high-definition biotechnology:
In terms of some of the big issues on tap this year that really stand out among the podium presentations and other educational programming, SLAS Director of Education Steve Hamilton says, "Continued growth of cellular assays, including single-cell technology. Also, machine learning continues to evolve, riding on the coattails of the broad technology market push in artificial intelligence."
Looking at some specific podium presentations that Hamilton thought might be particularly interesting to DDNews readers, he started with the presentation titled "Automating gene editing for deciphering cancer pathways using microfluidics" and noting that the use of microfluidics to automate CRISPR workflow represents an interesting combination of technologies.
Hamilton also told DDNews, "The development of antibody drugs is a very hot field. But the automated discovery platforms for this work have lagged behind that of small molecules because biologics are more challenging to work with." However, one example of automation development overcoming some of those challenges can be found in the presentation "Accelerating Discovery: Development of a High-throughput Mammalian Expression Platform as Part of a Fully Integrated Biologics Workflow."
Also, he notes, machine learning (artificial intelligence) is beginning to make its way into our daily lives in many ways, and that is true in the field of drug discovery, too. The presentation titled "Preparing Early Drug Discovery for the Machine Learning Revolution," he says, "describes custom software written at Merck that uses machine learning to assist scientists in their decision-making. It's early in this evolution, but this presentation shows how things are getting started."
Advances in fast and inexpensive DNA sequencing have allowed this tool to be used in ways never imagined before, Hamilton also noted, pointing to the podium presentation titled "High-throughput Binder Confirmation: A New Non-combinatorial Synthesis Platform Created to Enhance and Accelerate Hit ID," saying: "In this case, DNA is used to label and identify synthesized compounds that are screened in large pooled libraries to evaluate their drug-like efficacy."
Then there is the presentation "Evaluation of DESI-MS as a Novel Platform for Label-Free Ultrahigh-Throughput Screening" of which Hamilton comments, "Mass spectrometry (MS) is one of the fastest growing techniques for high-throughput screening detection. This paper describes a version of MS, desorption electrospray ionization MS, used for high-throughput screening platform."
Also of interest: "New approaches for single cell genome sequencing and mutation analysis," of which Hamilton notes, "The study of mutations in cells is key to understanding mutation-driven diseases, like cancer. Looking at the DNA sequences in individual cells is the ultimate way to follow mutation pathways. This paper explains a new approach for doing that type of analysis that requires far less specialized equipment than in the past."
Finally, Hamilton highlighted "Inflammation-on-a-Chip—High-Throughput Microscale Arrays for Human Neutrophil Swarming," a presentation that stands out for him because: "Developing disease models that reside on a microfluidic chip is a recently emerging technology. This paper describes developing such a model to study the very complex disease mechanisms of inflammation."
But as to why you should be attending SLAS annual meetings, or at least strongly considering doing so, SLAS Director of Marketing Communications Tom Manning says, "Ultimately, it's the unique combination of access to new technology, relevant, peer-selected education and abundant networking opportunities. What's especially unique about SLAS and this annual conference in particular is the unprecedented mix of attendees diverse in professional discipline (researchers, scientists, engineers, tech developers) and organization type (industry, academia, government, tech developers/providers) brought together under the unique SLAS culture of friendly collaboration."
Looking forward to SLAS2019
Obviously, much remains to be done after SLAS2018 to put together the next meeting, but the Society for Laboratory Automation and Screening did share with DDNews some high-level generalities for next year's meeting.
The conference site for next year's event (www.SLAS2019.org) was currently under development as of the writing of this article, but was expected to be live by end of January.
SLAS2018 keynote speakers
Monday, Feb. 5
Dr. Benjamin F. Cravatt will deliver the SLAS2018 opening keynote address. Cravatt is a professor and co-chair of the Department of Molecular Medicine at The Scripps Research Institute. His research group is interested in understanding the roles that enzymes play in physiological and pathological processes, especially as pertains to the nervous system and cancer.
Wednesday, Feb. 7
Marc Abrahams will deliver the SLAS2018 closing keynote. Abrahams writes about research that makes people laugh, then think. He founded Ig Nobel Prize Ceremony in 1991, and serves as its master of ceremonies. He co-founded and edits the magazine Annals of Improbable Research (AIR), hosts the Improbable Research weekly podcast (distributed by CBS), and wrote This is Improbable, The Ig Nobel Prizes and other books. He edits and writes much of the website and blog www.improbable.com and the monthly newsletter mini-AIR.
Meet the 2018 SLAS Innovation Award finalists
Ten podium presenters will vie for the $10,000 SLAS Innovation Award cash prize at SLAS2018. Hailing from academia, industry and government and selected by a panel of judges based on the potential impact of the innovation, originality/creativity and quality of science represented in their work are:
Details on each finalist, including their presentation abstracts and titles, can be viewed on the SLAS2018 Event Scheduler. The final judging takes place at SLAS2018.
2018 SLAS FUNd Run
On Your Mark, Get Set, Go!
Pack your running shoes. Start your Tuesday morning with a brisk run or walk along the San Diego waterfront with your fellow SLAS2018 attendees. This non-competitive event benefits the SLAS Educational Fund.
Date: Tuesday, Feb. 6
Start Time: 6:30 a.m.
Location: Roy's Restaurant at Marriott Marquis (Outdoors; Seaside Boardwalk)
Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
Saturday, Feb. 3
8 a.m. to 5 p.m.
Registration: This workshop is available to SLAS2018 registrants only and requires an additional registration fee of $399.
Summary: This full-day workshop will cover a broad range of critical concepts underlying assay development for high-throughput screening (HTS) and lead discovery projects. Many of the methodologies successfully implemented in such projects have been "tribal knowledge" within the pharmaceutical industry and not readily found in a classroom or the literature. This tribal knowledge has been developed for decades into detailed chapters within the AGM [Assay Guidance Manual] to facilitate reproducible assays that can identify the most promising compounds for development of molecular probes or clinical candidates for drug discovery and development. An increasing number of researchers are actively developing well validated assays for drug discovery that include phenotypic and biochemical assays for lead optimization. This workshop is designed to disseminate critical information about the implementation of robust assay methods and intended to benefit the entire drug discovery community. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery.
Who Should Attend? The target audience is individuals involved in bioassay development for drug discovery and development. The AGM and this workshop will be a valuable resource for academic, industrial and government laboratory scientists who are planning or beginning to develop test methods for high or low throughput screening that are amenable to automation using appropriate statistical and operational concepts. The workshop will also be useful for early career researchers and experienced investigators who wish to learn about the latest assay concepts for HTS and lead optimization.
Benefits: The workshop will provide participants with a broad, practical perspective on assay development so that they can: (1) improve research projects involving drug discovery, and know where to find further information; (2) identify reagents, methods and instrumentation that are well suited to robust assays; and (3) be able to develop robust assays and counter assays for new targets. Additionally, participants will have the opportunity to seek practical advice about individual research challenges.
Workshop Objectives:
Code: E011831
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Charles II
Charles II, 1630–85, king of England, Scotland, and Ireland (1660–85), eldest surviving son of Charles I and Henrietta Maria.
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The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.
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