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Public Health Statement for Chloromethane
December 1998
This Public Health Statement is the summary chapter from the Toxicological Profile for Chloromethane. It is one in a series of Public Health Statements about hazardous substances and their health effects. A shorter version, the ToxFAQs™, is also available. This information is important because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. For more information, call the ATSDR Information Center at 1-888-422-8737.
This public health statement tells you about chloromethane and the effects of exposure.
The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites make up the National Priorities List (NPL) and are the sites targeted for long-term federal cleanup. Chloromethane has been found in at least 172 of the 1,467 current or former NPL sites. However, it's unknown how many NPL sites have been evaluated for this substance. As more sites are evaluated, the sites with chloromethane may increase. This is important because exposure to this substance may harm you and because these sites may be sources of exposure.
When a substance is released from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment. This release does not always lead to exposure. You are exposed to a substance only when you come in contact with it. You may be exposed by breathing, eating, or drinking the substance or by skin contact.
If you are exposed to chloromethane, many factors determine whether you'll be harmed. These factors include the dose (how much), the duration (how long), and how you come in contact with it. You must also consider the other chemicals you're exposed to and your age, sex, diet, family traits, lifestyle, and state of health.
1.1 What is chloromethane?
Chloromethane (also known as methyl chloride) is a clear, colorless gas. It has a faint, sweet odor that is noticeable only at levels which may be toxic. It is heavier than air and is extremely flammable.
Chloromethane is produced in industry, but the it also occurs naturally, and most of the chloromethane that is released to the environment (estimated at up to 99%) comes from natural sources. Chloromethane is always present in the air at very low levels. Most of the naturally occurring chloromethane comes from chemical reactions that occur in the oceans or from chemical reactions that occur when materials like grass, wood, charcoal, and coal are burned. It is also released to the air as a product of some plants or from rotting wood.
In the past, chloromethane was widely used as a refrigerant, but refrigerators no longer use chloromethane because of its toxic effects. It was also used as a foam-blowing agent and as a pesticide or fumigant. A working refrigerator that is more than 30 years old may still contain chloromethane, and may be a source of high-level exposure. Today, nearly all commercially produced chloromethane is used to make other substances, mainly silicones (72% of the total chloromethane used). Other products that are made from reactions involving chloromethane include agricultural chemicals (8%), methyl cellulose (6%), quaternary amines (5%), and butyl rubber (3%). Chloromethane is completely used up so that by the end of the process there is no or little chloromethane left to be released, disposed of, or reused. It is, however, found as a pollutant in municipal waste streams from treatment plants and industrial waste streams as a result of formation or incomplete removal. There are also some manufacturing processes for vinyl chloride that result in chloromethane as an impurity in the vinyl chloride end product.
1.2 What happens to chloromethane when it enters the environment?
Chloromethane has been identified in air, surface water, groundwater, soil, and sediment. Most releases of chloromethane will be to the air. Chloromethane rapidly moves through the air and is present at very low concentrations throughout the atmosphere. Naturally occurring chloromethane is continuously released into the atmosphere from oceans, rotting wood, forest fires, and volcanoes. When grass, coal, or wood are burned, chloromethane is released to the air. The burning of grasslands and forests accounts for about 20% (ranging from 10 to 40%) of the total chloromethane in the air. Releases from the oceans account for another 80 to 90%. Chemical companies release some chloromethane gas to the air during the production of chloromethane or when it is used to make other substances, but the amount is relatively very small (0.2 to 0.6%) compared to natural sources of the total chloromethane in the atmosphere.
Chloromethane breaks down very slowly (months to years) in the air. Chloromethane can dissolve in water, and small amounts of chloromethane in air may go into surface waters or groundwater when it rains. Chloromethane can also enter water from industrial or municipal waste streams or from water that comes in contact with municipal or hazardous waste sites. Chemical companies generally treat waste water to remove chloromethane.
Chloromethane is a gas at room temperature, and when present in water, most will evaporate rapidly to the air. Small amounts of dissolved chloromethane may move below the surface of the water or be carried to the groundwater. It breaks down very slowly (months to years) in plain water, but certain kinds of small organisms in water may break it down more quickly (days). When chloromethane comes in contact with soil it does not stick to the soil. Most of the chloromethane in soil will move to the air. Some may dissolve in water and move down through the soil layers to the groundwater or into well water. Chloromethane does not concentrate in sediments, or in animals and fish in the food chain.
1.3 How might I be exposed to chloromethane?
Most (99%) of the chloromethane in the environment comes from natural sources. Because chloromethane is made in the oceans by natural processes, it is present in air all over the world. In most areas, the outside air contains less than 1 part of chloromethane in a billion parts of air (ppb). In cities, human activities, mostly combustion and manufacturing, add to the chloromethane in the air, resulting in somewhat higher levels, up to 1 ppb. Chloromethane exposures in the less than 5 ppb range are much lower (1,000 to 10,000 times lower) than the exposure levels that have been shown to have toxic effects. Chloromethane is also present in some lakes and streams and has been found in drinking water (including well water) at very low levels in the parts per billion to part per trillion (ppt) range. Chloromethane may be formed to a small extent in tap water that has been chlorinated. You could be exposed to levels in air higher than the background levels if you live near a hazardous waste site or an industry that uses chloromethane. If chloromethane is present at waste sites, it can move through the soil into underground water. We have very little information on the levels of chloromethane in groundwater. Chloromethane is not generally found in food.
The people most likely to be exposed to increased levels of chloromethane in the air are those who work in chemical plants where it is made or used. Chloromethane is also an impurity in vinyl chloride when the vinyl chloride is produced by heating another chemical, 1,2-dichloroethane. Exposure to chloromethane can occur from this kind of vinyl chloride or the disposal of vinyl chloride waste from this process. The proper enforcement of workplace regulations and the recycling of chloromethane during the manufacturing process help prevent worker exposures to levels that would be considered harmful. In the past (more than 30 years ago), chloromethane was also widely used as the refrigerant in refrigerators. Some of these old refrigerators may still be in use or may be located in storage areas. Chloromethane may be released from leaks in these refrigerators, leading to potentially very high exposures, especially in areas with poor ventilation. Liquid contact could also occur following a leak in an older refrigerator containing chloromethane. Other general population sources of chloromethane exposure include cigarette smoke; polystyrene insulation; aerosol propellants; home burning of wood, grass, coal, or certain plastics; and chlorinated swimming pools. The chloromethane in the outdoor environment, however, is almost totally from natural sources.
1.4 How can chloromethane enter and leave my body?
Chloromethane can enter your body through your lungs, if you breathe it in, or through your digestive tract if you drink water containing it. The chloromethane that you breathe in or drink rapidly enters the bloodstream from the lungs or the digestive tract and moves throughout the body to organs such as the liver, kidneys, and brain. Very little of the chloromethane that enters the body remains unchanged. The portion of the chloromethane that does not get changed in your body leaves in the air you breathe out. The rest is changed in your body to other breakdown products that mostly leave in the urine. The breakdown process takes anywhere from a few hours to a couple of days.
Breathing air that contains chloromethane vapor is the most likely way you would be exposed if you live near a hazardous waste site. Contact with liquid chloromethane is rare, but could occur in an industrial accident from a broken metal container. Prolonged skin contact with liquid chloromethane is unlikely, because it turns into a gas very quickly at room temperature. It is not known how much chloromethane liquid or gas will enter the body through contact with the skin, but the amount is probably very low.
1.5 How can chloromethane affect my health?
If the levels are high enough (over a million times the natural levels in outside air), even brief exposures to chloromethane can have serious effects on your nervous system, including convulsions, coma, and death. Some people have died from breathing chloromethane that leaked from refrigerators in rooms that had little or no ventilation. Most of these cases occurred more than 30 years ago, but this kind of exposure could still happen if you have an old refrigerator that contains chloromethane as the refrigerant. Some people who were exposed to high levels of chloromethane while they were repairing refrigerators did not die, but they did have toxic effects like staggering, blurred or double vision, dizziness, fatigue, personality changes, confusion, tremors, uncoordinated movements, nausea, or vomiting. These symptoms can last for several months or years. Complete recovery has occurred in some cases, but not in others. Exposure to chloromethane can also harm your liver and kidney, or have an effect on your heart rate and blood pressure. If you work in an industry that uses chloromethane to make other products, you might be exposed to levels that could cause symptoms resembling drunkenness and impaired ability to perform simple tasks.
To protect the public from the harmful effects of toxic chemicals and to find ways to treat people who have been harmed, scientists use many tests.
One way to see if a chemical will hurt people is to learn how the chemical is absorbed, used, and released by the body; for some chemicals, animal testing may be necessary. Animal testing may also be used to identify health effects such as cancer or birth defects. Without laboratory animals, scientists would lose a basic method to get information needed to make wise decisions to protect public health. Scientists have the responsibility to treat research animals with care and compassion. Laws today protect the welfare of research animals, and scientists must comply with strict animal care guidelines.
Harmful liver, kidney, and nervous system effects have developed after animals breathed air containing high levels of chloromethane (one million times higher than natural levels). Some of these animals died from exposure to high levels of chloromethane. Similar effects were seen in animals that breathed low levels continuously and animals that breathed high levels for shorter periods with some breaks from exposure.
Animals that breathed relatively low test levels of chloromethane (but still one hundred thousand to one million times higher than background levels people are exposed to) over a long period (weeks to months) had slower growth and developed brain damage. Some male animals were less fertile or even sterile or produced sperm that were damaged. Females that became pregnant by the exposed males lost their developing young.
Male mice that breathed air containing chloromethane (one million ppb) for 2 years developed tumors in their kidneys, but female mice and male and female rats did not develop tumors. It is not known whether chloromethane can cause sterility, miscarriages, birth defects, or cancer in humans. The Department of Health and Human Services (DHHS) has not classified chloromethane for carcinogenic effects. The International Agency for Research on Cancer (IARC) calls chloromethane a Group 3 compound, which means it cannot be determined whether or not it is a carcinogen because there is not enough human or animal data. The Environmental Protection Agency (EPA) considers chloromethane possibly carcinogenic to humans (i.e., Group C) based on limited evidence of carcinogenicity in animals.
1.6 How can chloromethane affect children?
This section discusses potential health effects from exposures during the period from conception to maturity at 18 years of age in humans.
Children may be exposed to chloromethane from the same sources as adults. These sources include outside air, indoor air, and drinking water. Exposures are generally well below safe levels. The people most heavily exposed to chloromethane are workers in chemical plants where it is made or used. With proper safeguards to prevent children from entering these work areas, children would not be expected to have high exposures. Old refrigerators that used chloromethane as a refrigerant and that are leaking chloromethane, however, are a potential source that could result in high exposures to children.
There have been no studies on whether children are more or less susceptible than adults to harmful health effects from a given amount or chloromethane. We do not know if chloromethane affects the developing fetus or the development of young children. There is no information on exposure to high levels of chloromethane in children (for example, accidental poisoning), but we expect similar effects to those seen in adults (including harmful effects on the nervous system and kidneys). We do not know if the effects for children would be similar to those in adults for lower levels or for longer exposures. There have been no studies where young animals were exposed to chloromethane. Animal studies have shown that female adult rats that were exposed to chloromethane during pregnancy had young that were smaller than normal, with underdeveloped bones, and possibly abnormal hearts (although this effect remains uncertain).
We do not know if chloromethane or its breakdown products in the body can cross the placenta and enter into the developing young. We also do not know if chloromethane or its breakdown products can enter into a nursing woman's milk. We do know that chloromethane is broken down and eliminated from the body very quickly in adults. Although we expect the breakdown and elimination of chloromethane to be the same in children as in adults, more studies are needed to answer this question and the other questions concerning the movement of chloromethane into the fetus or into nursing young through breast milk, and what amounts might result in harmful effects.
1.7 How can families reduce the risk of exposure to chloromethane?
If your doctor finds that you have been exposed to significant amounts of chloromethane, ask your doctor if children may also be exposed. When necessary your doctor may need to ask your state Department of Public Health to investigate.
Families can reduce the risk of exposure to chloromethane by properly disposing of the older types of refrigerators that used chloromethane as a refrigerant. If you live near a chemical plant that makes or uses chloromethane, or near a hazardous waste site that stores it, you should teach your children not to play in or around these sites. If family members work in a chemical facility that manufactures or uses chloromethane, they should become familiar with the safety practices that are used to prevent exposure to harmful levels. They should also become familiar with their rights to obtain information from their employer concerning the use of chloromethane and any potential exposure they might be subject to at work.
You should teach your children about the dangers of breathing smoke from burning vinyl plastic or silicone rubber products, and should properly dispose of all such products. Chloromethane (as well as other toxic compounds) is released from burning polyvinyl chloride. If you are concerned that chloromethane may be in your drinking water, you can have your water tested and learn about the proper water filter to use to remove chloromethane (as well as other possible contaminants) from your drinking water. If you are concerned that products you are using might contain chloromethane, you can check the labels for ingredients or contact the manufacturer for additional information.
1.8 Is there a medical test to determine whether I have been exposed to chloromethane?
There are no known reliable medical tests to determine whether you have been exposed to chloromethane. Symptoms resembling drunkenness and food poisoning, along with a sweet odor of the breath, may alert doctors that a person has been exposed to chloromethane.
1.9 What recommendations has the federal government made to protect human health?
The federal government develops regulations and recommendations (sometimes called advisories or guidelines) to protect public health. Regulations can be enforced by law. Federal agencies that develop regulations for toxic substances include the Environmental Protection Agency (EPA), the Occupational Safety and Health Administration (OSHA), and the Food and Drug Administration (FDA). Recommendations provide valuable guidelines to protect public health but cannot be enforced by law. Federal organizations that develop recommendations for toxic substances include the Agency for Toxic Substances and Disease Registry (ATSDR) and the National Institute for Occupational Safety and Health (NIOSH).
Regulations and recommendations can be expressed in not-to-exceed levels in air, water, soil, or food that are usually based on levels that affect animals; then they are adjusted to help protect people. Sometimes these not-to-exceed levels differ among federal organizations because of different exposure times (an 8-hour workday or a 24-hour day), the use of different animal studies, or other factors.
Recommendations and regulations are also periodically updated as more information becomes available. For the most current information, check with the federal agency or organization that provides it. Some regulations and recommendations for chloromethane include the following:
To protect workers, OSHA has set a regulation of an average permissible exposure limit of 50 parts of chloromethane per million parts of workroom air (50 ppm) during each 8-hour work shift in a 40-hour workweek.
Agency for Toxic Substances and Disease Registry (ATSDR). 1998. Toxicological profile for Chloromethane. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Where can I get more information?
If you have questions or concerns, please contact your community or state health or environmental quality department or:
For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop S102-1
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO
ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.
- Page last reviewed: January 21, 2015
- Page last updated: January 21, 2015
- Content source: Agency for Toxic Substances and Disease Registry


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Love the part you see the sky change! Amazing vid!
Clear Sky Complete is a part of the Complete mod collection, which is a series of modifications created by professional artists dedicated to enhancing the S.T.A.L.K.E.R. games. The Complete mods focus on improving the original game's graphics, sound, and atmosphere, while preserving its core elements. Built upon the success of STALKER Complete 2009 (which was downloaded well over 200,000 times), this entry in the Complete collection continues the tradition of aesthetically updating the game without changing the original story or gameplay. Fans can expect a polished and pure Zone experience designed around the most graphically demanding title of the S.T.A.L.K.E.R series - S.T.A.L.K.E.R. Clear Sky.
Love the part you see the sky change! Amazing vid!
Great vid, showed some really cool stuff!
Only registered members can share their thoughts. So come on! Join the community today (totally free - or sign in with your social account on the right) and join in the conversation.
Video edited by Sniffero.

subset: commoncrawl


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SYNOPSIS: • Liberty Shoes is the flagship company of the Liberty Group, a leading footwear company in India and one of the largest manufacturers of leather footwear in the world with a turnover exceeding U.S. $100 million.
• The company is now focusing on the domestic market in a big way. "Liberty Shoes is bullish about retail. It is now ramping up retail and distribution channel in India."
• Liberty launches Autumn-Winter 2009 Collection.
• Credit rating agency, ICRA has revised the rating assigned to the Rs.300 million Commercial
Paper/Short Term Debt (STD) programme of Liberty Shoes (LSL) from A1 to A2+. The revised rating indicates above-average-credit quality in the short term1.
• Foot Mart Retail, the joint venture between Pantaloon Retail and Liberty Shoes, seems to be on
shaky grounds due to a couple of operational issues. The JV did not take off as planned, and Future Group may pump in more funds and up its stake in the venture. While Liberty Shoes will continue to be a stakeholder in the business, the operational control could move to Future Group.
To read the full report: LIBERTY SHOES


text: At 07:29 25/08/99 -0700, you wrote: >Sound a lot like our concurrency test. Does our concurrency test >pass? I've not been able to run "make test" (yet) with openLDAP 2.0. But I did with OpenLDAP 1.3.6 and it worked. I guess these tests use default values for cachesize (1000) and dbcachesize (100000). With these values, my tests work also. To prove I do not only bring bad news, I can tell you the memory leaks seem to be gone with OpenLDAP 2.0-alpha (hurray) ;o) >At 04:18 PM 8/25/99 +0200, Frédéric Poels wrote: >>At 14:39 25/08/99 +0200, I wrote: >>>Good afternoon! >>> >>>I've had the bad (or good?) idea to change some parameters of a >>>multi-threaded OpenLDAP 1.3.6 slapd server running on AIX 4.2.1: >>>cachesize=100 >>>dbcachesize=200 >> >>I did the same with OpenLDAP-2.0-alpha2... >>I also tried using a size greater than sizelimit (you never now). >> >>>The directory contains about 15000 entries. I perform the following >>>operations: >>>- A process forks 15 times, each son binds to the LDAP server and perform a >>>different search which returns about 1000 entries. The father waits for its >>>sons to terminate and then exits. >>>- It works pretty well :o) >>>- I do it again >>>- All sons return "No such object" :o( >>>- Any request sent to the LDAP server fail with the "No such object" reason >>>code :o/ >> >>Same behaviour. > >Any clues in the server logs? > >Kurt > >


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Web Content ViewerActions
Budget Billing
We know balancing your budget can be difficult when your utility bill is high one month and low the next. That's why UI offers Budget Billing for residential customers.
With Budget Billing, UI will bill you for an average monthly electric cost based on your actual use. To make sure your budget stays on track, every six months we'll compare your Budget Billing Amount with your previous 12 months of actual use. For most customers, there will be no adjustment. However, if your account shows a significant change, we'll adjust your monthly budget amount. This new charge will then appear on your next month's bill.
If you are on Budget Billing and decide to change to a new electric supplier, your budget payment amount will be recalculated and you will be charged a new payment amount based on your past 12 month usage history and your new supplier's price. If you choose to change electric suppliers multiple times during your budget year, during your regular adjustment month all budget plans will be balanced. When the new budget year takes affect, any differences between your previous budget charges and actual charges accrued will be due. Overpayments will be credited to you immediately, and any monies owed by you must be immediately paid to continue your participation in budget billing.
At the end of each budget year you don't have to do anything to stay on the plan, we'll renew it automatically. Customers whose accounts are current qualify for this free service. You can cancel this plan at any time.
Please call 800 7CALL UI (800.722.5584) to get more information about Budget Billing.


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My name is Taylor and I am from Alaska. I have always had an interest in fashion and after finishing college, I figured it was time to take something I really like and turn it into a hobby.
My blog is meant to show my take on fashion, trends, style, health, and beauty. It's also meant to show style on the modest end of the style spectrum. You don't have to show everything off to look beautiful. Modesty doesn't have to look drab. I hope this blog inspires someone!


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Vancruisers.ca is Copyright
by Bryn Hughes
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 2.5 Canada License.
Vancruisers.ca is offered for the convenience of the cycling community. Vancruisers, the site owner, maintainers, etc are not responsible nor endorse the activities listed.
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Will a divided Europe bring down its common currency?
Issued on: Modified:
The debt crisis is spreading across Europe; the same politicians who bashed Greece for living above its means now need to change their rhetoric in a hurry, argue François Picard's panelists.
From Brussels:
Eric BRIYS, Associate Professor of Finance at University of French West Indies, co-founder of cyberlibris.com
Philippe D'ARVISENET, Global Chief Economist at BNP Paribas bank & Associate Professor of Economics at Paris University-Sorbonne
Tarik MOUAKIL, Economist, Author of Asset Markets, Portfolio Choice and Macroeconomic Activity
Produced by Pauline Heilmann, Yi Song, Mary Colombel, Sara Bertilsson
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I don't know when the hell this was decided but apparently "Quarantine 2: Terminal" will hit theaters on June 17th. Of course it will be limited, which means probably a total of 8 theaters will be showing it. Half of those will be in a bunch of crappy theaters in the middle of the Village and the other half in equally crappy theaters in LA, all of which will be filled with pricks. Save me a seat!
For those of you who have been waiting for the "Nightmare on Elm Street" sequels to hit Blu-Ray I've got good news and bad news. The good news is both 2 & 3 in the series are being released on September 27th. The bad news is they're going to be released on one disc so I'm guessing special features are going to be pretty slim. And the news that I had a lovely weekend is probably not good or bad to you. Jerk.
David Arquette is a director now! Well alright I guess he's directed some TV and crap but "Glutton" is the first movie I've actually noticed his name attached to and what's more is his sister Patricia Arquette has now been cast as the sister of a morbidly obese bedridden man which the movie focuses on. Am I the only one who's slightly turned on by this movie premise? Yes? I should have figured.
Some good Blu-Ray news for you though is that Steven Spielberg himself has confirmed that "Jaws" will in fact be released on the magical disc in the near future. He's also confirmed that there will be no digital enhancements of any kind done to the film and it will be left in its true original glory. Which makes me wonder why I need a 37th version of the movie but I'm sure I can find a reason. I'm really good at talking myself into things.


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How to keep your food safe if Hurricane Sandy cuts electricity
With Hurricane Sandy threatening to cut power, many people are worried how long their food can last in the refrigerator and freezer without electricity. But, there's other food safety issues that people should be concerned about.
The USDA has compiled a list of tips to help you sort through what is safe to eat in order to avoid food poisoning and other foodborne illnesses in the event of a power outage.
The top three things to remember are:
Meat, poultry, fish and eggs should stay at or below 40 degrees F and frozen food should remain below 0 degrees F.
- If you keep your refrigerator up, you will be able to keep your food cold for up to four hours. A full freezer will keep its temperature for at least 48 hours if full, 24 hours if half full.
- Putting food together in your fridge and freezer can help keep it cold, the FDA points out.
- The FDA also said coolers can help keep refrigerated food keep cold once the power cuts out.
- Make or buy dry or block ice while you can. Fifty pounds of dry ice should keep an 18-cubic foot full freezer for two days.
- You'll have to discard most foods in your fridge, but hard cheeses -- including Cheddar, Colby, Swiss, Parmesan, provolone, Romano - butter or margarine; opened fruit juices; opened can fruits; Fresh fruits, coconut, raisins, dried fruits, candied fruits, dates; most spreads that do not include milk products; breads; pies; and raw vegetables may be safe even if not kept cold. For a full list of foods, check out FoodSafety.gov's list.
- If the item has ice crystals and feels as cold as it had been refrigerated, you can refreeze hard cheeses; breads, rolls, muffins, cakes without custard fillings; fruit juice; vegetable juice; cakes, pies, pastries with custard or cheese filling; casseroles - pasta, rice based; flour, cornmeal, nuts; breakfast items including waffles, pancakes, bagels; and frozen meal, entree, specialty items (pizza, sausage and biscuit, meat pie, convenience foods). However, most food will have to be thrown out if it has thawed for over two hours and is over 40 degrees F. A checklist can be found at FoodSafety.gov.
Stock up on foods that can be eaten cold or heated with a gas stove.
- Shelf-stable food, boxed or canned milk, water, and canned goods should all be safe to eat in case of an emergency.
- Have a stock of ready-to-use baby formula and pet food if you need it.
Food tainted by flood water, which contains bacteria, is not safe
- Throw away any food that is not in a waterproof container if there is a possibility it touched flood water. This includes screw-cap bottles, snap lids, pull tops, and crimped caps. Food in cardboard boxes is not safe.
- Any cans that are swollen, leaking, punctured, rusted or crushed so badly they cannot be stacked should also be discarded.
- Remove labels on cans that are waterproof because they can contain dirt and bacteria.
- Wash all the cans with soap and water. Hot water is best if available. If possible, place them in boiling water for two minutes or a solution made from 1 tablespoon of unscented bleach to one gallon of drinking water for 15 minutes. Air dry cans for at least 1 hour before opening or storing them. Use salvaged food as soon as possible, and mark which cans were cleaned and sanitized with a pen.


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Struggling, aspiring, or established WoW cartoonists!
I'm headed out of town for a week in late May and would love to give an enterprising WoW comic a leg up with readership. We're lucky to have wonderful, loyal readers- around 5,000 a day- and it seems a shame to waste the opportunity to promote MOAR COMIQS!
If you'd like to try your hand, email me at firstname.lastname@example.com with your reasoning. A sample of work would be a delightful and helpful addition.
The winner will be selected based purely on personal preference. Funny, interesting, sad, bizarre- whatever (WoW-related) comic you'd like to showcase is fair game.
Bon chance!


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The new leader of Thailand's pro-government "red shirt" movement said on Monday that his supporters would take to the streets in support of Prime Minister Yingluck Shinawatra if the elite or the courts dared try to oust her.
The red shirts have kept to the sidelines during the past 4-1/2 months of political unrest in Thailand, while anti-government protesters forced state offices to close and disrupted an election in February.
Any further threat to Yingluk could see their patience snap, warned Jatuporn Prompan, who became leader of the United Front for Democracy against Dictatorship (UDD), as the red shirts are formally known, at the weekend.
Thousands of supporters attended the rally in Ayutthaya north of Bangkok to witness the change of leadership.
"We're going to fight tooth and nail to defend this government but we will do so peacefully," Jatuporn told Reuters on Monday.
"Thailand's political crisis will not end with these street protests. This is about the Bangkok elite denying grassroots people the right to play a part in the democratic process. We can't let this go on."
The crisis pits protesters, mainly middle class Bangkok residents and southerners backed by the military and the establishment, against supporters of Yingluck and her brother, ousted former premier Thaksin Shinawatra, from the rural north and northeast.
If the red shirts were to launch counter protests it would risk escalating violence, and could further destabilise Yingluk's government. Their restraint, however, could disappear, under the new leader.
Jatuporn helped organise the uprising against a previous government that ended in a bloody military crackdown in May 2010, and supporters like his no-nonsense attitude.
He replaced Thida Thawornseth, a former member of the banned Communist Party of Thailand whose schoolteacher demeanour and lofty speeches left some wondering whether she was out of touch with the movement's grassroots supporters.
"Thida had the theories, but Jatuporn is a man of action. We can count on him to lead us," said Chinawoot Eak-pan, an office security guard and red shirt supporter from Bangkok.
Jatuporn still faces terrorism charges related to the violence in 2010.
On Monday, Thai army chief Prayuth Chan-ocha called Jatuporn "a bandit", telling reporters that "if they (red shirts) are aggressive towards the military, I'll be aggressive, too".
Weakened by the agitation against her, Yingluck faces a raft of legal challenges that could force her out, the most prominent being charges of negligence over a ruinous rice subsidy scheme.
Twenty-three people have been killed in politically related violence in Bangkok and eastern Thailand since late November.
On Monday, two home-made bombs were found and destroyed by bomb disposal teams outside the Office of the Attorney General in Bangkok, police said.
With the noose tightening around Yingluck's Puea Thai Party, many government supporters believe Jatuporn's skills as a fiery orator will rally the support her government needs to hold on.
Red shirt supporters say they are prepared to fight back if the government they helped put in office is removed.
Despite signs of a split in the movement, the red shirts remain a potent force and are largely loyal to Thaksin, seen by many as the real power in the country.
The protesters in Bangkok say they want to curb Thaksin's influence, remove Yingluck and install an unelected "People's Council" that would oversee wide-ranging political reforms to dilute their chances of winning election again.
Jatuporn has said he will avoid a confrontation with the demonstrators but some analysts say it could still happen.
"He's capable, if Thaksin told him to, of having the red shirts engage in violence," said Paul Chambers, director of research at the Institute of South East Asian Affairs in Chiang Mai. "There is a message that is being sent to the elite with Jatuporn's accession, which is: 'This is the person who really might create havoc for you'."


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May 2, 2005
Tim Flowers, updating the Indiana Guide to Hiring and Firing with Baker and Daniels in Fort Wayne. He will be working with Drew Welborn '93 and David Miller (the father of Wabash senior Adam Miller). It's a new Wabash program that seeks to immerse a student interested in law, specifically in labor law; Reynaldo Pacheco , in Ecuador for a month with the Wabash Program. Then will be in La Paz Bolivia, directing the Philharmonic of La Paz. We will directing "Chicago"; Jacob Straub, will work in father's restaurant in Rolling Meadows, Ill.; Adonis Joseph , Mishawaka, IN, work at First Source Bank, summer school; Kevin Shaw , Juneau, AL, will be working as an actuarial intern at Conseco Inc. in Indianapolis, plans to return home to Alaska for a short duration at the end of the summer; David Fitzgerald, working as a sales intern at the RCA Tennis Championship tournament, he will also be overseeing six or seven workers who will man the phones during tournament time; Brandon Hall, McCall, ID, working with inter-agency fire department and building 'timber framed' furniture which he has been doing for two years; Nick Hunter, Summer Business Immersion Experience then getting married August 6th. Chris Ogden, finance internship with Eli Lilly; Matt Boston , internship with Haelen Group, Wabash connection: Jim Kerr '96 VP; Mike Lawlor, internship at Wabash with Math faculty in the area of abstract algebra. Also included, Chris Jackson; Chip Habegger , working at Saks Fifth Avenue in NYC with a merchandising internship, Fred Wilson '69 is the CEO; Matt McKay, got a Dill Scholarship to attend a national stage combat workshop in Las Vegas; Ben Nguyen, will be interning with Development Associates Inc. in Washington D.C. It was with the Jim Graham externship organized by both NCAWM (National Capitol Association of Wabash Men) and the Career Office. My mentor for that externship was Mr. George Jones '55; Abhi Shaw, working for Indiana Secretary of State, Todd Rokita '92; Bryan Roesler, going to Israel to study Hebrew at the University of Haifa thru a Dill Grant; Greg Mahoney , Mishawaka, IN, working for St. Joseph Capital Bank as a business analyst; Stephen Dewart, Chicago, may work for Apparatus started by Kelly Pfledderer '96; Pete Kempf, Fort Wayne, IN, working for Juvenile Diabetes Foundation doing fundraising; Gable Hackman, Marine Officers Candidate School in Quontico, VA; Raul Gonzalez, Texas, Englishton Park as therapist. This is a camp for kids with depression that need assistance to cope with their lives. The camp is in Lexington IN. Aaron Hollowell, Union City, IN, Fastenal Company (Lebanon branch). This is a major industrial/construction supplies supplier. I will be in charge of daily activity at the store, account management, and deliveries; Jeff Sostak, Boston this summer for an internship helping an Kevin McCrea '88 in his campaign for Boston city council; Andrew Wells, working for Todd Rokita along with Abhi Shaw; Brandon Roop, will be working for a Registered Investment Advisor in Evansville; Nathaniel Eakins , Montana for the summer and work as a white-water rafting guide for the Flying Pig Rafting Company. The owner is Geoff Faerber '98. Faerber played basketball at Wabash, Eakins will be working alongside Josh Jones '07; Michael Bohling, Summer Business Immersion Experience; Andrew DeYoung, Summer Business Immersion Experience; Travis Grace, Norcote, Inc. Got job through CEO of company, Herm Haffner '77; Mark Server, Cook Inlet Aquaculture Association; Joal Beane, and Kyle Harry, are working with IU medical center in Evansville this summer in the biomedical sciences; Kevin Pazour, working on prospect research at Chicago's Field Museum.
Patrick Miller, working with Dr Porter on an Independent Nanotechnology project. If not the Porter research, then working at a medical school or somewhere doing bio major-nerd-type stuff; Thant Zin Htun, working as an intern for Present Indiana Project for 2 months. It is basically research about Indiana. My tentative concentration is how science and technology has changed Indiana; Tony Caldwell, will be working for a production/research plant in my hometown (Washington, IA) for Novartis Seeds, a subsidiary of Syngenta, Inc. I'm be doing some work on corn and soybean research, some production stuff, and general plant projects; Mauricio Solano, will be participating in the Ecuador program and during the second part of the summer we will be volunteering in a Hospital; Adam Kirsch, has an internship in the Indianapolis Mayor's Office. Steve Campbell '92 was a big supporter of getting Wabash students for internships and not only I, but also Elliot Vice received an internship; Matt Kanter , planning to work/shadow my dentist Dr. Jeff Heister '95 for a few weeks. After that, I will be in Australia for a month. Then, tentatively planning to work/shadow/intern with Todd Shellenbarger '87. He is the Asst. U.S. District Attorney in Evansville; Kyle Sell, will be doing research with Professor Robert Horton for the second half of the summer. We will be doing some research in the realm of social psychology; Braden Pemberton, will be interning for with Professor Jim Fisher in the theater department; Brock Johnson, after a brief vacation in Greece then Scotland, has Dill Grant to study in Munich.
Manbar Khadka, will be participating in Wabash's "Summer Business Immersion Experience."; Tahir and Zuber Ahmed, will be working on the Present Indiana Project; Justin Boomer, plans on working in Toledo for a Wabash Alumnus that is head of Mercy Medical Group. Most likely working in one of the Mercy hospitals in Toled St. Annes, Toledo Hospital, or St. Lukes; Ross Dillard, will be participating in the Summer Business Immersion program; Brett Gann, will be spending the first part of summer break producing Crawfordsville's Vanity Theater children's production "The Hobbit." He will return home to Peoria, Illinois at the beginning of June to take courses preparing him to study in London next semester; Steven Rhodes, will be involved in two internships, one with Dr. Lon Porter in the Wabash Chemistry Department over the month of May continuing with my research on synthetic transformations on organic monolayers bound to porous silicon. From June through August he will be working at the Cornell Center for Materials Research at Cornell University in Ithaca, NY with Professor David Putnam on a project called "Controlled Drug Delivery from New Biomaterials"; Shane Keffer, working for an Anheuser-Busch distributorship over the summer in the extremely hot Arizona heat; Patrick Banks, will work for Red Cross in HIV/AIDS education; Allen Chatt, will be participating at the Center for Language Studies at Beloit College, WI., studying first-year Arabic.


text:
Human (Parental) Breast Cancer Stem Cell - T25 Plated Cells
Also Avaliable as:
Frozen Vial Cells $550.00 shipped with Dry-ice. Cat#36102-29P
T75 plated Cells $750.00 shipped at room temperature. Cat#36102-29P-T75
120 Population doublings or up to 12 passages.
This product would require pre-coated flasks with Human (Parental) Breast Cancer Stem Cell Extra-cellular Matrix Cat# E36102-29P and Human (Parental) Breast Cancer Stem Cell Media Cat# M36102-29P
Cell Cultures from single donors, 1000 different cell cultures available, please indicate which lots you require from the 1000 donors, or any subcategories of the cancer type at the time of order. If you do not specify the subcategory, we will provide you the Human Parental Breast CSC, randomly from our inventory.
Source: Human (Parental) Breast Cancer tissue.
Positive Markers:CA15-3, HER 2 , Progesterone , Estrogen, Ephrine B4 +ve, CA 27.29
For non-academic use please inquire for pricing.
Cells are only guaranteed with purchase of Celprogen Media and Celprogen Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.
1000 individual donors are fully characterized proprietary patient-derived xenografts (PDX) representing all major histotypes and capturing tumor diversity.
Subcutaneous, orthotopic and disseminated models. Extensive molecular and pharmacological characterization as well as information on patients' pretreatment to help you select the most appropriate model.
Integrated approach: use the same PDX models and/or the corresponding cell line in 2D/3D screening assays and follow-up in vivo studies, identify biomarkers predicting tumor sensitivity for your compound.
Individually tailored study designs: proof of concept, dose level and schedule optimization, combinations, biomarker identification, etc.
Aryl Hydrocarbon Receptor is a Transcriptional Activator of the Human Breast Cancer Resistance Protein, BCRP,ABCG2
Poster - Human Triple Negative Breast Cancer Stem Cells Publication
Human HER2+ Breast Cancer Stem Cells Publication
Poster - Human HER2+ Breast Cancer Stem Cells Publication
Poster - Drug Discovery Therapeutics for Triple Negative Breast Cancer Patients Publication
Drug Discovery Therapeutics for Triple Negative Breast Cancer Patients Publication
Cancer Stem Cells Being Utilized in Cell-based Assay Screening Publication
The Role of CXCR3-Ligand Axis in Cancer Aryl Hydrocarbon Receptor is a Transcriptional Activator of the Human Breast Cancer Resistance Protein, BCRP,ABCG2
Correlation between Cancer Stem Cells and Circulating Tumor Cells and Their Value
Drug Resistant Breast Cancer Cell Line Displays Cancer Stem Cell Phenotype and Responds Sensitively to Epigenetic Drug SAHA
Optimization of siRNA Transfection for Breast and Glioa Cancer Cell Cultures
Phenotypic Plasticity in Normal Breast Derived Epithelial Cells
Poster-Metastatic Profile of Breast CSC and CTC
Protein Kinase C-delta Inactivation Inhibits the Proliferation and Survival of Cancer Stem Cells in Culture and In Vivo
Silencing NOTCH signaling casuses growth
View Product Data Sheet
View Safety Data Sheet
View Compliance Documents


text:
Rotor-Gene SYBR® Green PCR Demo Kit
For evaluation of Rotor-Gene Q performance
The Rotor-Gene SYBR Green PCR Demo Kit is for use in demonstrating the performance of the Rotor-Gene Q in combination with Rotor-Gene master mixes. The kit contains all the necessary reaction components to quantify a genomic DNA target by SYBR Green-based real-time PCR. These include prediluted genomic DNA standards, 2 unknown samples, an optimized master mix, and a primer pair specific for the human G protein-coupled estrogen receptor 1 (GPER) gene. Using the kit, the reliability, reproducibility, and sensitivity of gene quantification with the Rotor-Gene Q can be evaluated.
Buy Products
The Rotor-Gene SYBR® Green PCR Demo Kit is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
Product Details
High-precision in real-time PCR can be achieved using the combination of Rotor-Gene Kits and the Rotor-Gene Q real-time PCR cycler. The ready-to-use master mix supplied with Rotor-Gene Kits allows fast and accurate gene quantification without the need for reaction optimization, while the Rotor-Gene Q employs a unique centrifugal rotary design. PCR tubes are placed into a rotor that spins tubes past a single excitation light source and a single detector in a chamber of moving air. This means that there is minimal optical and temperature variation between tubes, enabling high precision in real-time PCR quantification. In addition, as the rotor spins continuously at 400 rpm, high-speed data acquisition is possible.
With the Rotor-Gene SYBR Green PCR Demo Kit, highly specific amplification is assured through a balanced combination of ions that minimizes nonspecific primer annealing (see figure "Specific primer annealing"). Fast cycling without compromising performance is achieved using Q-Bond, a novel PCR additive that enables cycler run times of as low as 45 minutes (see figure "Fast primer annealing").
Using the Rotor-Gene SYBR Green PCR Demo Kit, SYBR Green-based real-time PCR is carried out to quantify different copy numbers of a genomic DNA target. Each reaction consists of:
The Rotor-Gene SYBR Green PCR Demo Kit handbook contains 3 protocols. Rotor-Gene users follow either the protocol for manual reaction setup or the protocol for automated reaction setup using the QIAgility. After reaction setup, users then proceed to the protocol for real-time PCR on the Rotor-Gene Q.
Manual pipetting steps can be avoided by using the QIAgility, a compact benchtop instrument that provides rapid, high-precision PCR setup. Mistakes in reaction setup due to human error are reduced and may be eliminated. The QIAgility perfectly complements the combination of the Rotor-Gene Q and Rotor-Gene Kits, enabling easy dispensing of liquids into tubes, strip tubes, and Rotor-Discs.
A standard curve is generated from the CT values obtained from a set of standards (2000, 1000, 500, 250, and 125 copies; each standard is analyzed in quadruplicate). The standard curve is then used to determine the copy number for 2 unknown samples (500 and 250 copies; 24 replicates of each unknown sample are analyzed [when performing manual reaction setup, a minimum of 4 replicates for each unknown sample can be set up instead]). In addition, 4 no template control (NTC) reactions are carried out. Thus, a total of 72 reactions are run at the same time on the Rotor-Gene Q.
The Rotor-Gene SYBR Green PCR Demo Kit is for use in demonstrating the performance of Rotor-Gene Kits in combination with the Rotor-Gene Q. The kit is also compatible with the Rotor-Gene 3000 or the Rotor-Gene 6000. Using this kit, the accuracy and reproducibility of gene quantification with the Rotor-Gene Q can be evaluated.
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text:
|ドン Don
|Naruto Shippūden Episode #254
|Appears in
Don (ドン, Don) is a koala residing on the Island Turtle. He is one of the four fiercest animals to reside there.
According to Condor, Don is trapped in a four-way lovers spat with King, Hippo Boss and Chūji over the affections of Armadiko. Whenever the four are together, they immediately start fighting believing themselves to be the most suitable partner for Armadiko.
Don is a very hard-headed individual who will not back down from a challenge as noted by Condor who states that he would not back down from the challenge over Armadiko's affections even though he feared King.
Don is a grey koala with light markings around his eyes and ears and along his body. He also has three, vertical scars on his forehead. When introduced, Don resembled an Italian mafia boss wearing a brown suit, a matching bowler hat, with a red scarf draped over his shoulders and a lit cigar in his mouth. By the time Naruto Uzumaki was carrying out his mission on the island, he had on no clothing at all.
Part II
Fourth Shinobi World War: Countdown
At the time of the recruitment of all the animals on the island by Naruto, Don was seen fighting Chūji and Hippo Boss. As King joins the fray, Don and the other are easily defeated by the gorilla. However, when Armadiko arrives and tells them that she had fallen in love with Naruto, the four animals band together and declare that they are going to beat him to death. This leads to Don chasing after Naruto across the island. Later, sulking and somewhat beaten up, Don and the other join the line entering the temple. Seeing Armadiko cosy up to Naruto, they look on in jealousy before quickly looking away as Naruto asks them if they want to fight again.
Later outraged when Naruto declares that he was going to start the ecological survey which required that he see the animals' genitalia in order to know their sexes, Don and the others voice their dissent when Naruto states that he wanted to know whether or not Armadiko was female because of the kanji pattern for male on its armour. Soon after this, tremors are felt on the island and the animals are then thrown into the air after the Island Turtle is flipped over. Saved by Yamato's quick thinking, Don and the others are shocked when they see that an unconscious Armadiko is actually male. The four are then seen commiserating the revelation.
- In chapter 513, when running a mission ecology on the Island Turtle a koala that resembles Don can be seen.
- The term "don" is an honourific that is famous for being used as the title for Italian mafia bosses, which Don first dressed as when he débuted.


text: I've owned an Imbel FAL and they are accurate reliable soft shooting rifles if adjusted properly. If it wasn't ejecting the remington ammo it is probably because it isn't as hot as the surplus ammo. To adjust the gas system to get it to operate with what ever ammo you're using, open it up all the way and shoot a round/close the valve 1 click until you start getting failures to eject. Then open it back up 2 clicks and it should work just fine with that ammo. Congrats on the Fal and welcome to GUNCO!!!


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DIY Tutorial - How to Make Home Baked Twinkies
Yes, you heard me right... home baked Twinkies! I saw those words in this photo from Lisa M's Magic Show 7th Birthday and had to learn more, much more. Lisa sweetly put together this tutorial and all I can say is thank you and... yum!
Hi there! I am Lisa from MooreMinutes and I am super happy to be sharing here today! I'm a party-lover. I feel passionate about making every moment in life count and using celebrations to cultivate beauty.
Recently I hosted a Magic Show Party for my son's 7th birthday. When creating the dessert area, I wanted to focus on classic desserts in a homemade form. We had homemade Oreos, donuts, and Twinkies!
Today I want to share some little tips with you on baking Twinkies in your home sweet home.
This Twinkie recipe is automatically an instant winner because it comes from King Arthur's Flour website. Their recipes are total perfection. I'm only sharing the tips here. For full recipe details, see King Arthur's Flour.
You can make your Twinkies look exactly like the Hostess Bakery ones by using a canoe pan. However, I used a traditional muffin pan for mine.
The secret ingredient in homemade Twinkies is Princess Flavoring! You can purchase it at Hobby Lobby.
The biggest tip when making these is to beat the egg white until they are VERY stiff. They should be able to completely hold their shape. It is also important to be extra gentle when folding the egg whites into the batter. Don't stir or mix. Simply fold the batter over the egg whites until the whites are covered.
After your Twinkies cool, it's time for the fun stuff! Filling the centers with that amazing cream is super easy! Prepare your cream according to the recipe and fill a pastry bag.
Turn the Twinkie upside down and gently press the pastry tip into the bottom of the Twinkie. Squeeze the cream in...but...don't squeeze too hard or else the Twinkie will explode. {wink}
Fill in three different places on the bottom of the Twinkie so it will certainly be puffy with sweet cream!
Ta da! You're done!
They are ready to embellish. You can use any pretty cupcake liners to set them in and top with adorable cupcake toppers.
Lisa, we couldn't agree more. Thank you for putting this together. These look sooo delicious. I can't wait to try them. My family is going to flip!
To learn more about Lisa, please check out her blog, MooreMinutes, where you can read about her adventures in entertaining, parties, and home decor. Also, check out the other insanely amazing parties she's added to our site.
5 comments
Leanne wrote:
Oh My! Those look amazing! I love Lisa and her blog. She always has such great ideas.
Stacey H wrote:
So wonderful and creative. I love this idea. I agree Lisa is fantastic and I love her blog too!
Dorey wrote:
Yum! Lisa's food and parties ALWAYS look amazing! :D
Nancy wrote:
Looks super good! Thanks for sharing your secrets Lisa!
Chriss wrote:
hope to get more information soon ... thanks because my children like this!
To leave a comment Log in -or- Join the party


text:
Wolf Blitzer delivers the most important breaking news and political, international, and national security stories of the day. Tune to The Situation Room weekdays 5-7pm ET on CNN.
CNN's Brian Todd reports on criticism that the timing for the release of a movie about the bin Laden raid is political.
RELATED STORY: Osama bin Laden movie to air weekend before election
This is just another spinning of a wheel that has already been spun to the point of falling off. I say what about Libya? Why don't you report full accessible web front page on that?
A film---really, that is real time news. Of course our president is all about "Hollywood" Can anyone say "Star Struck" I hope that is the Presiden't next gig then he can say," I'm not the President" but I played one on TV--CNN, ABC, MSNBC, NBC,etc....
If it is a polictical stunt ,it's a good one
This is a wicked act, inviting the terrorists to hurt the country "whatsoever a man soweth, that shall he also reap" –
(Galatians 6: 7)
Who cares? At least this movie will be factual unlike those put out by the repubs.
If it is a polictical stunt ,it's a good one.Our President got him.
All tv's have an off botton use it
You must be logged in to post a comment.


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This mod aims to fix bugs and add missing features to Luke Moloney's Homeworld Classic Mod. It is a seperate installation, not an update or a patch. Quote (From Luke Moloney's Homeworld Classic Mod): "Welcome to the Homeworld Classic Mod. This mod attempts to implement the multiplayer features of Homeworld 1, AKA Homeworld Classic, in Homeworld 2. "The following features are implemented: * Unlimited unit caps * Carrier battle * Win condition - capture enemy capital ship * Resource injections * Resource lump sum injection * Bounties * Research disabled * Crates * Hyperspace disabled"
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text:
PAYDAY: The Heist
PayDay 2 and PayDay: The Heist have sold over 9 million units combined
The PayDay franchise is a lucrative IP for Starbreeze and Overkill, as both games combined have sold over 9 million copies as of November 2014.
PAYDAY: The Heist headlines
Payday: The Heist is free to download this Thursday
Payday developer Overkill Software is offering Payday: The Heist for free this Thursday, October 16.
PS Plus: July update adds free Battlefield 3, Payday & more
PlayStation Plus subscribers can look forward to free downloads of Battlefield 3 and Payday: The Heist in July, among others. Get the full details here.
Payday: The Heist is 75% off on Steam
Payday: The Heist is 75% off on Steam as part of its midweek madness incentive until August 9. In addition, the Wolfpack DLC featuring new weapons, heists, skills and upgrades is also available for $9.99.
Payday: The Heist Wolfpack DLC hits US PSN next week
Sony has announced the Wolf Pack DLC for Payday: The Heist will be available in North America next week. Available on August 7 for $9.99, the DLC contains the Undercover and Counterfeit heists along with new weapons and crew members such as the the Technician, and new Trophies as well. It's out today in Europe.
Mercy Hospital DLC for Payday: The Heist now available on Steam
The free Mercy Hospital DLC is out today on Steam for Payday: The Heist. The content includes a map from Left 4 Dead, and those who own the first version of Valve's shooter or L4D2 will get a zombie mask to wear in Payday. There's more, though: "We also have some extra candy hidden in […]
Payday: The Heist getting Left 4 Dead's "No Mercy" map
It looks as though the Overkill and Valve cross-over project with left 4 Dead undertones is the No Mercy map.
Overkill working with Valve on "in-depth" Payday/Left 4 Dead "collaboration"
Overkill Entertianment has announced it's working with Valve on what it calls an "in-depth collaboration" involving Payday: The Heist and Left 4 Dead.
Steam update outs new Payday: The Heist DLC
New DLC is inbound for Payday: The Heist, entitled The Wolf Pack DLC, according to the latest update given to the game by Steam. The pac will feature two new heists, a Technician skill tree, three new weapons, a new crew bonus, new player upgrades, deployable sentry gun and a higher level cap.The shooter also […]
PAYDAY: The Heist free-to-play this weekend only
Want to get in on some bank-robbing action, without all the drama of getting involved with the police and that whole "criminal record" thing? Then cancel your weekend plans, because here's your chance: PAYDAY: The Heist is running a free weekend, where you can dip your toes in these murky waters without fear of retribution.If […]
PAYDAY: The Heist Xmas Update released on Steam
Overkill Software has announced that the next time PAYDAY: The Heist players load their Steam client, and special Christmas update will be applied. One of the new features is present available on any of the levels in multiplayer, which contains a Santa mask. Apparently, players will also "get the chance to be surprised later on." […]
PAYDAY: The Heist releasing in the UK and Europe November 2
As promised earlier this week, Sony has announced a European release date for PAYDAY: The Heist. Already available in the US and worldwide on PC, the game will launch on PS3 November 2 for the UK and Europe. Those who ordered all the titles offered through Sony's PS Play incentive, will receive the game for […]
Payday: The Heist PC gets October 20 release date
Sony Online Entertainment has finally announced the release date for the PC version of co-op bank robbing sim Payday: the Heist, and it's, uh, tomorrow – October 20.The PlayStation 3 version of the game arrived on the US PSN this week, but we still haven't heard when the European storefront will be graced by it.Thanks, […]
Heat Street video released for PAYDAY: The Heist
To celebrate its North American launch today, Sony and Overkill have released a new video for PAYDAY: The Heist. A date for Europe and the PC version are still to be announced. The game will run you $19.99 on PSN, or will be free for those who purchased all the games which were part of […]
Payday: The Heist launching next week
Sony Online Entertainment's launching co-op shooter Payday: The Heist will launch next Tuesday, October 18 in the US. There's a minute-long clip of it in action below, via the US PS Blog.
PAYDAY: The Heist - Green Bridge cinematic trailer released
Gamespot has posted a video for PAYDAY: The Heist. The Green Bridge cinematic trailer can be watched below. The game is expected in October on PSN. Those who ordered all the titles offered through Sony's PS Play incentive, will receive the game for free upon release.
Payday: The Heist is replay friendly
Payday: The Heist may only feature six banks, but Overkill Software says it has endless replayability.
Quick shots: Panic Room screened for PAYDAY: The Heist
You've seen the trailer, now check out screenshots of the Panic Room in OverKill's PAYDAY: The Heist, which is slated for digital release on PSN and PC this year. The price and exact date have yet to be announced by SOE.
Wednesday Shorts - Trailers, comics, Facebook, Robin Williams, more
I have to go to the doctor, so forgive me for dumping this massive pile of news on you and fleeing gleefully. Good stuff in snack portion size lies within.
Sony to invest $20 million in exclusive PSN game portfolio
Sony has announced it is to invest $20 million in its Pub Fund to develop PSN exclusive games.
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PAYDAY: The Heist latest
PayDay 2 and PayDay: The Heist have sold over 9 million units combined
Mercy Hospital DLC for Payday: The Heist now available on Steam
Overkill working with Valve on "in-depth" Payday/Left 4 Dead "collaboration"
Wednesday Shorts – Trailers, comics, Facebook, Robin Williams, more
Saturday Shorts: MW3, CCP, RIFT, Vita, Ace Combat, Hitman, sales
Payday: The Heist described as "seriously cool, seriously profane, and seriously fun"


text:
At 10 days and counting, Minnesota's state government shutdown has already lasted longer than any in recent U.S. history.
And there's no sign it will end soon.
No new budget talks were scheduled over the weekend, and the two sides seem farther apart than ever on patching the state's budget crisis. In an ominous conclusion to the week, DFL and GOP party leaders held dueling news conferences Friday to clobber one another and assign blame.
"I don't see a quick conclusion," said Rep. Larry Howes, R-Walker. "If this thing goes to the State Fair, it will probably go to January. That's my gut."
The longer the shutdown lasts, the deeper the impact across the state.
Even bars and restaurants could start feeling the pain as state-issued cards that allow them to buy liquor begin to expire.
When its previous two-year budget ended last month, the state was forced to lay off 22,000 workers, close state parks and halt hundreds of road projects. That left Minnesota alone among the 50 states. And it may not be long before things get more dire.
A string of court orders now temporarily funds K-12 schools, the court system, health and human services and local government aid -- about 80 percent of state spending.
And because there is no new budget, the court is paying out funds based on older, higher spending assumptions. That means the state treasury is beginning to burn through what could become hundreds of millions of dollars more than it is taking in.
"If we keep spending more than we are bringing in, we will run out of money," said Jim Schowalter, commissioner of Minnesota Management and Budget. "We don't have a huge cushion."
Even more alarming to many local governments: Many of the court-ordered payments -- which sometimes come in a few large chunks each year -- will likely be reduced as part of a final budget deal, particularly state aid to cities and counties.
Meanwhile, crowded or worn schools facing pressure to complete new buildings or remodel by the fall could see their projects suddenly stop because out-of-work state inspectors can't visit the sites. And new teachers might not get licensed before the start of the school year.
The University of Minnesota and the state's higher education system would have to limp along without state aid. State grants for students could be in peril. Businesses and professionals needing permits could also be out of luck.
The price of gridlock
Across the state, some bars are facing the prospect of losing their lifeblood, alcohol.
The Liberty Restaurant and Bar in St. Michael, for example, might have to shut its doors when its supply of booze dries up at the end of the week.
"I have two options," said Norm Freske, the bar's general manager. "One, I can continue to serve food, obviously with no alcohol. Or we shut down."
The St. Paul Hotel stocked up on beer, wine and liquor before the shutdown. The hotel can't buy more, but general manager David Miller said it can hold out at least a month. "It's annoying more than anything," Miller said.
Restaurants could see profits drop if they have to substitute $2 glasses of soda for $10 glasses of wine.
School officials are also bracing for a host of shutdown-related problems.
Toward the end of summer, for example, officials from the state's 350 school districts must begin the process of setting property tax levies. If a school district wants residents to vote on a referendum for a new building or project, the state education department must sign off. That can't happen until state government reopens.
"From the smell of it, it feels like it could go on quite some time," said Charlie Kyte, outgoing executive director of the Minnesota Association of School Administrators.
Minnesotans counting on rebates and refunds from the state are also out of luck. Roughly 70,000 tax refunds totaling $90 million won't be issued until the two sides strike a deal.
At the Capitol, many legislators and staff members now being paid out of short-term cash reserves could be off the job if the shutdown slides too far into summer.
Where's the urgency?
The intensifying national spotlight on Minnesota's shutdown isn't helping matters.
Fitch Ratings last week lowered the state's credit rating, which means it will now cost the state more to borrow money for new schools, roads and even a possible new stadium for the Minnesota Vikings.
"They've put us on notice that we aren't addressing the crisis," Schowalter said.
Despite mounting fiscal pressures, and the new aggravations and hardships the shutdown is imposing on average Minnesotans, Capitol leaders appear in no rush to strike a deal.
Last week both sides quickly dismissed key parts of a plan put forth by a bipartisan group of political elders that advocated solving the budget problem through a mix of deep spending cuts and new taxes.
"I don't think we've ever had a situation like this in the history of Minnesota," said state Rep. Tom Rukavina, DFL-Virginia.
Tom Hanson was a top official for Gov. Tim Pawlenty during the brief 2005 shutdown. The bickering now has led him to a simple conclusion: "There's no end in sight."
Staff writer Bob von Sternberg contributed to this report. Baird Helgeson • 651-222-1288


text:
Natural History of Stroke: Cause and Development
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00009243
Recruitment Status : Recruiting
First Posted : January 25, 2001
Last Update Posted : October 30, 2020
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to learn more about stroke and obtain information that may serve as the basis for future investigations. It will 1) establish a registry of patients with cerebrovascular disease (stroke); 2) characterize the natural history of acute stroke and transient ischemic attacks (TIA) an interruption of blood flow to the brain that causes stroke symptoms for a short period of time); and 3) evaluate the data to generate ideas for future studies.
Patients 18 years of age or older with suspected acute stroke or TIA may be eligible for this study. Subjects will be recruited from patients who present with stroke at the emergency department of Suburban Hospital in Bethesda, Maryland.
The study will gather data collected from diagnostic and laboratory tests the patient undergoes as part of standard medical care, including findings of medical and neurological examinations and other tests. In addition, studies will be done for research purposes only to gather data about stroke and TIA. These may include the following:
- Blood and urine tests not more than 2 tablespoons of blood will be drawn for various tests.
- Electrocardiogram (EKG) (heart tracing) electrodes placed on the chest wall detect the heartbeat and heart rhythm.
- Computed tomography (CT) scan of the head specialized X-rays are used to obtain images of the brain.
- Magnetic resonance imaging (MRI) of the brain a strong magnetic field and radio waves are used to produce images that provide information about the brain tissue and blood vessels.
- Transcranial Doppler (TCD) sound waves are used to image the arteries of the brain and neck.
- Echocardiogram sound waves are used to image the heart and evaluate heart function.
Patients may be asked to return to Suburban Hospital for follow-up testing in 1, 3, and/or 12 months, when some of these tests may be repeated to assess changes over time
|Condition or disease
|Brain Disease Ischemic Attack, Transient Cerebrovascular Accident Cerebrovascular Disorder Vascular Diseases
OBJECTIVE: This is a natural history/disease pathogenesis protocol for evaluation of patients with or at risk for acute stroke, transient ischemic attack (TIA), or other disturbances of cerebrovascular circulation. The purpose of this protocol is to generate natural history data to serve as the basis for future hypothesis-driven protocols as well as to contribute to the clinical and physiological understanding of cerebrovascular disease through the description of disease manifestations and the relationship among clinical, hematologic, and radiologic variables, as well as identifying potential subjects for future studies on stroke and other cerebrovascular diseases.
STUDY POPULATIONS: Patients will be recruited from the collaborative stroke program between NINDS and affiliated hospitals and will be followed for the duration of their hospitalization. Select subjects will then be seen for follow for up to one year.
DESIGN: Clinical issues to be addressed will include disease manifestations, natural history, acute disease management, and psychological/behavioral impact of the disease. Because of the nature of acute cerebrovascular disease, it is important to note that the research performed under this protocol will not interfere with emergency clinical evaluation or treatment of subjects, as specified in the clinical care pathway in place for the standard care of stroke patients at participating hospitals. Due to the emergency nature of clinical evaluation and therapy for stroke patients, waiver of written informed consent in certain circumstances for minimal risk procedures during acute period (e.g., collecting extra tubes of blood during initial phlebotomy for emergency room blood tests) will be required when it is impossible to obtain consent prior to critical emergency treatment procedures that may change the values of the variables. Patients will not be treated with experimental therapies as part of this protocol. Data collected under this protocol may be shared with other NIH researchers and databases and the National Institutes of Neurological Disorders and Stroke (NINDS) Repository if the subject approves this option in the informed consent.
OUTCOME MEASURES: In addition to clinical, imaging and laboratory data that are part of routine clinical care of the patient, a variety of outcomes will be collected, e.g., infarct volume, clinical outcomes on NIH Stroke Scale, modified Rankin Score, Barthel Index, blood marker of inflammation, coagulation and gene expression. Statistical analysis plans will be developed as specific questions and hypotheses are generated.
|Study Type :
|Estimated Enrollment :
|3000 participants
|Observational Model:
|Time Perspective:
|Official Title:
|Evaluation, Pathogenesis, and Treatment of Patients With or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)
|Actual Study Start Date :
|January 26, 2001
Patients with acute stroke symptoms
- Prevalence and type of abnormalities seen on neuroimaging as a function of time from acute insult [ Time Frame: Post-acute, 24 hours, 5 days/discharge, 30 days, 3 months, 6 months, 12 months ]Neuroimaging abnormalities, such as:-Imaging positive for acute ischemic cerebral vascular syndrome ( AICS positive )-Presence of a lesion on diffusion, perfusion, and mismatch between the two-Evidence of a vascular occlusion on MR angiography-Evidence of a thrombus or hemorrhage on T2* GRE imaging-Blood-brain barrier disruption as evidence by HARM-The evolution of these markers with time and treatment
- Stroke severity as measured by NIHSS as a function of time since index event [ Time Frame: Post-acute, 24 hours, 5 days/discharge, 30 days, 3 months, 6 months, 12 months ]
- Clinical outcome measured using modified Rankin Scale and Barthel Index [ Time Frame: 5 days/discharge, 30 days, 3 months, 6 months, 12 months ]
- Gene expression profiles and biomarker levels obtained from blood samples [ Time Frame: Post-acute, 24 hours, 5 days/discharge, 30 days, 3 months, 6 months, 12 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
- Age greater than 18
- Patient is less than 18 years of age.
Subjects with contraindication to MRI scanning will be excluded from any testing which involves the use of MRI. These contraindications include subjects with the following devices or conditions:
- Central nervous system aneurysm clips;
- Implanted neural stimulator;
- Implanted cardiac pacemaker or defibrillator;
- Cochlear implant;
- Ocular foreign body (e.g. metal shavings);
- Insulin pump;
- Metal shrapnel or bullet;
- Any implanted device that is incompatible with MRI.
Subjects with a condition precluding entry into the scanner (e.g. morbid obesity, claustrophobia, etc.) will not be included in the MRI portion of this study. Pregnant women will be excluded from testing which involves the use of MRI.
- Subjects will be excluded from 7T imaging if they are at risk of aspiration or have any condition that may require precipitous removal from the scanner.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00009243
|Contact: Mariam Afzal
|(301) 435-2269
|Contact: Lawrence Latour, Ph.D.
|(301) 496-0463
|United States, District of Columbia
|Washington Hospital Center
|Washington, District of Columbia, United States, 20010
|United States, Maryland
|Suburban Hospital
|Bethesda, Maryland, United States, 20814
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Lawrence Latour, Ph.D.
|National Institute of Neurological Disorders and Stroke (NINDS)
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Institute of Neurological Disorders and Stroke (NINDS)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|January 25, 2001 Key Record Dates
|Last Update Posted:
|October 30, 2020
|Last Verified:
|October 28, 2020
Natural History
Magnetic Resonance Imaging
MRI (Magnetic Resonance Imaging)
Acute Stroke
Brain Diseases
Cerebrovascular Disorders
Ischemic Attack, Transient
Vascular Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Nervous System Diseases
Brain Ischemia


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Difference between revisions of "File Release System/6.1"
|Line 41:
|Line 41:
== Package/Release/File ==
== Package/Release/File ==
=== Package ===
=== Package ===
==== Creation ====
==== Creation ====
Revision as of 15:16, 2 November 2017
This page in other versions: master
FusionForge provides a feature to organize deliverable/product/file releases. Organized by package, release, files, this feature relies on RBAC for permission.
- 1 Main Features
- 2 Available Widgets
- 3 Activation
- 4 Permissions
- 5 Main Page
- 6 Package/Release/File
- 7 Import/Export
- 8 Reporting
Main Features
- unlimited organized packages/releases/files
- public/private packages
Available Widgets
user oriented widgets
project oriented widgets
forge oriented widgets
To enable this system at forge level, the configuration flag use_frs must be set to yes. Per project, the system can be enable/disable through the Project admin tab.
Relying on RBAC, FRS permissions are splitted into 2 groups.
- FRS access level permissions:
- No access: Any access to FRS is disabled.
- FRS access: When set, the per package setting applies
- FRS Administration: when set, then role has full access to any package and any action over package/release or file.
- Per Package permissions:
- No access: disable any access to the package and his content.
- Read access: can browse/download files/releases in the package
- File Management: create/modify/delete files in the package.
- File & Release Management: create/modify/delete files & releases in the package.
- Package admin: full permission on any action on the package/release/file.
The section Default for new packages applies when new package is created.
Main Page
- View File Release:
- Reporting:
- Administration:
FusionForge proposes to organize hierarchicaly binaries/deliverables or any other items. One package can include unlimited number of releases which include unlimited number of files. There are no relation between different releases of the same package. There are no rules to name packages or releases.
inject-files.php script
The inject-files.php is located in ~/fusionforge/bin/ directory. This script must be executed on the FusionForge hosting server.
The script creates packages based on the content of a parameter file files.txt which must be located in the same directory than the script.
The content of files.txt file must respect the following format:
- each line describe one file.
- each line must have 8 parameters separated by colons.
- project: the unixname of the project
- packagename: name of the package. If package does not exist, the package is created.
- releasename: name of the release. If release does not exist, the release is created.
- filepath: full path to the file to attach to the release
- notes: Notes of the release. Only used if release does not exist.
- changes: Changes of the release. Only used if release does not exist.
- type: File Type. Integer. See below for values.
- processor: Processor Type. Integer. See below for values.
type and processor values are respectively ids from frs_filetype and frs_processor.
- type values taken from SELECT * from frs_filetype:
1000 | .deb [...] 5000 | Source .zip 5010 | Source .bz2 5020 | Source .gz [...] 5900 | Other Source File [...] 9999 | Other
- processor values taken from SELECT * from frs_processor:
1000 | i386 6000 | IA64 [...] 8000 | Any [...] 9999 | Other
Example of file:
demoproject:MyPackageA:'1.0':/path/to/the/release/file:'new release':'security fix':5010:9999
forge command line
The forge command line is located in ~/bin/ directory.
The command line supports package/release import or export. Detail information here


text:
Welcome to Florida Gulf Coast University's 2011-2012 academic catalog. This catalog is available exclusively online.
The information contained in this catalog is intended for informational purposes only for the 2011-2012 academic year. This catalog includes general information about the university, as well as information on policies, procedures, academic programs and course information. Every effort is made to provide this information as accurately as possible at the time of publication; however, the university reserves the right to revise any section or part without notice or obligation.
Students who must reapply and are readmitted must follow the catalog in effect at the time of their readmission. Administrative regulations are not catalog specific and are subject to change at any time. Catalogs from previous academic years should be used for historical reference only as the content may no longer be accurate. Please refer to the current catalog for updated information.
This catalog may be obtained in an alternative format by contacting the Office of Institutional Equity and Compliance at (239) 590-7405 or (800) 590-3428, or the Office of Adaptive Services at (239) 590-7956. If you are hearing- or speech-impaired, call the appropriate FGCU office via the Florida Relay at 711 (TTY, VCO, HCO, ASCII or Speech-to-Speech).
Florida Gulf Coast University is accredited by the Commission on Colleges of the Southern Association of Colleges and Schools (1866 Southern Lane, Decatur, Georgia 30033-4097; Telephone number (404) 679-4500 to award associate, baccalaureate, master's, and doctoral degrees.
Florida Gulf Coast University is committed to equality of educational experiences for students and is an Equal Opportunity employer.


text:
Respond faster to new threats. Reduce false positives for a better customer experience. SAS Fraud Management uses industry-leading data analytics and machine learning to monitor payments and nonmonetary transactions, as well as events, enabling you to identify and respond to unwanted and suspicious behavior in real time.
Make faster, better-informed risk-based decisions across your organization.
Our end-to-end fraud detection and prevention solution supports multiple channels and lines of business, enabling enterprisewide monitoring from a single platform. The solution simplifies data integration, enabling you to combine all internal, external and third-party data to create a better predictive model tuned to your organization's needs. Bringing together this data on a single technology platform gives you the flexibility to scale up or out as your business changes, and respond faster to new threats as they arise.
Find fraud faster and reduce revenue loss.
Stay on top of shifting tactics and new fraud schemes. Embedded machine learning methods detect and adapt to changing behavior patterns, resulting in more effective, robust models. Key technology components let you easily spot anomalies for each customer. In-memory processing delivers high-throughput, low-latency response times – even in high-volume environments – enabling you to score 100 percent of transactions in real time. Our patented signature-based approach captures customer behavior data from multiple sources and analyzes it for patterns and inconsistencies every time a transaction is processed.
Keep customer satisfaction high.
Better fraud detection capabilities and faster response times lead to fewer false positives, which translates to less customer inconvenience. When fraudulent behavior is detected, alerts are scored and prioritized, enabling immediate customer self-service, or fast review and assessment, reducing the chances of wrongly declined transactions that would adversely affect the customer journey.
Key Features
- Real-time transaction scoring and decisioning. Score 100 percent of all transactions in real time with in-memory processing that delivers the industry's highest throughput and lowest latency response times.
- Single platform. Multitenancy capabilities enable the sharing of a single installation among independent departments and channels.
- Simplified data management. Seamlessly integrate all your data regardless of source or type – including third-party data.
- Advanced analytics and machine learning. Generate real-time, risk-based decisions with robust, embedded profiling and machine learning capabilities, patented signature-based analysis technology, advanced analytic modeling controls, a rule-authoring application interface, and an alert triage workstation.
- Alert management. Handle alert resolution, manage payment and risk decisions, perform hot listing and blocking, and conduct downstream fulfillment actions from a single interface.
In times of digitalization, banks must focus on innovating in the fight against fraud and money laundering. Therefore, we're using an analytical SAS platform to be able to act and react even faster.
Stopping Payment Fraud in Its Tracks
Is your organization equipped to defend itself against the fast-growing and rapidly changing world of payment fraud? Watch this video to learn how SAS Fraud Management can help you stop fraud in its tracks by monitoring all events and transactions in real time, gleaning maximum insight from third-party data and quickly identifying fraudulent behavior patterns.
Recommended Resources
Learn more by reading the SAS Fraud Management fact sheet.
Find out how you can supercharge your fraud detection techniques.
Discover how to reduce payment fraud losses while lowering associated costs.


text:
Egypt riot police clash with Muslim Brotherhood supporters ahead of referendum
CAIRO - Riot police clashed with supporters of Egypt's ousted Islamist president on Friday, leaving 11 dead in ongoing street battles where an increasing number of protesters are carrying firearms ahead of a key referendum they urge to boycott later this month.
Fighting spread through heavily populated residential areas in several cities and provinces including Cairo, Giza, Ismailia, Fayoum, as hundreds of Muslim Brotherhood members and their supporters threw rocks at security forces who responded with water cannons and tear gas.
Black smoke hung in the air as protesters burnt tires and hurled Molotov cocktails and fireworks at black-clad security forces. A number of police vehicles were set on fire, public buses were damaged and main roads blocked by protesters.
The Health Ministry said that 11 people, including three in Cairo, were killed and more than 52 injured in the protests. A Brotherhood-led alliance said on its Facebook page that the death toll had reached 19.
Full coverage: After the Arab Spring
In the Mediterranean city of Alexandria, an Associated Press cameraman saw dozens of armed protesters carrying homemade pistols and engaging in violent clashes with security forces, despite Brotherhood claims that protests are peaceful. In the eastern district of Sidi Bishr, 50-year-old Zeinab Abdel-Hamid was killed by a gunshot.
The Interior Ministry said in a statement that 122 Brotherhood protesters were arrested carrying homemade grenades and Molotov cocktails.
Violent protests have been recurrent since the military ousted Mohammed Morsi in a July 3 coup after millions of anti-Islamist protesters demonstrated to demand his resignation.Egyptian General Abdul Fattah al-Sisi's growing cult-like following
The numbers of those hitting the street in support of the Brotherhood - Egypt's most organized political group - have dwindled dramatically over the past months after the military-backed interim government launched a crackdown. Hundreds were killed when authorities broke up protest camps, thousands of Brotherhood members have been arrested and scores were sent to trial.
Friday's protests however appeared to be the largest and most violent since a three-month state of emergency and nighttime curfew expired in November.
The government has sought to drain the group's resources, ordering last week the seizure of assets of hundreds of non-governmental groups on suspicions of links to the Brotherhood. Hundreds of the group's leaders and businessmen have also had assets seized.
Over the past months the group changed tactics, relying more on women and student supporters to lead protests ahead of two main events: the second session of Morsi's trial on Jan. 8 on charges killing of protesters, and the upcoming referendum on a new constitution drafted by a secular-leaning assembly on Jan. 14 and Jan. 15.
In latest blow to the Brotherhood, the government designated it a terrorist organization and accused it of having ties to a known al-Qaida-inspired group called the Champions of Jerusalem. It has claimed responsibility for many attacks including a deadly Dec. 24 bombing of a security headquarters in a Nile Delta city.
The interim government considers the referendum a milestone in a transition plan it laid out ahead of Morsi's ouster, which envisions presidential and parliamentarian elections in the coming months. The draft charter is an amended version of the 2012 constitution drawn up by an Islamist-dominated panel under Morsi, which was suspended during the coup.
In a strongly worded Friday sermon, Minister for Religious Endowments Mohammed Mokhtar Gomaa warned against supporting calls by protesters to stop paying utility bills to oppose the government, in reference to a Brotherhood-led campaign.
"Those aiming to topple the state are enemies to God and the Prophet" he said at the Al-Hussein mosque in downtown Cairo.
Also on Friday, three explosions targeted a military and police convoy in the volatile northern Sinai Peninsula, wounding four soldiers, a security official said.
The explosions, one of which was from a roadside bomb, hit near the town of Sheikh Zuweid, close to the border with the Gaza Strip, he added, speaking on condition of anonymity in line with regulations.
Despite the clashes, Fitch Ratings raised Egypt's economic outlook from negative to stable, although its issuer default ratings and country ceiling remained at B-.
The international agency attributed the improvement to major aid from countries in the Persian Gulf after Morsi's ouster that amounted to billions of dollars in grants and deposits that had "eased pressure on reserves."
The oil-rich countries had been at odds with Morsi's Brotherhood group and feared that its offshoots in their countries would challenge ruling royal families.