text:
Pujols resting before starting offseason work
Angels slugger won't need surgery, expects to begin routine in November
ANAHEIM -- Albert Pujols is an intense and extremely competitive person.
The Angels' first baseman tore his left plantar fascia in late July and was shut down for the season on Aug. 19. But a little over two weeks ago, he started running and riding the bike just in case the Angels worked their way into the playoff picture, although he admitted the "odds weren't in our favor."
Now that the Angels are eliminated from the postseason, Pujols has shut it down and is letting his body rest until he begins his offseason routine.
"I think we're all very comfortable and confident that he is going to be at a much higher level of health than we've seen, even parts of last year, and definitely this year," manager Mike Scioscia said. "I think when you put the equation together, that's going to add up to an Albert much along the lines of what we saw after the first month of '12.
"Through the lion's share of the season, he got banged up a little bit, but you saw everything. The power is there, the swing is there, and hopefully he'll be able to maintain it through a whole season."
The tear of the plantar fascia accomplished what surgery would have so Pujols will not need offseason surgery.
In fact, he anticipates going through his regular offseason routine, which includes weight training and conditioning in November, and hitting in January.
"I feel good about everything and how everything is going," Pujols said.
Pujols will not be back on the field until 2014, but that does not mean he is ignoring the Angels' recent success.
Pujols is proud of the character his teammates have shown as they continue to fight until the end of the season and wishes he were healthy enough to partake.
"It [stinks]," Pujols said. "Very disappointing, but it's not like I could control it."


text:
Queue longer than Downtown Mall for Obama
55 comments
Why are the public schools closing ?
Because their logic was to have the kids home before the President's route down 29 North into the city of Charlottesville. I don't think they did a good job of it though - they knew of this weeks ago and they could have made alternative arrangements.
"I was not going to close 186 classes,"
But they closed most of the local public schools early. Who loses here.
Typical UVA arrogance! The place is a dump anyway!
@Fratboy...I totally agree with you. I think it's ridiculous for UVA to snub any president who would like to speak on campus, I mean...really? He's the president. I don't think the "equal time" argument holds much water either. If Romney wants to come speak on campus, he should be welcome as well. What a great thing for the students to be exposed to. Shame on president Sullivan for not welcoming our nation's leader to the campus with open arms. Popular or not, convenient or not, he runs the country we all live in.
Michelle cancelled. I expect he will to. That storm and all.........Go Hoos
I am not so quick to criticize Sullivan over this. Shutting down the entire University for the day at the last minute is a big deal, and it's more so with the amount of security involved. I also think it makes it a lot less accessible to anybody but the University. Now it's equal opportunity. Students can get DT as easily as anyone else.
UVA officials offered the JPJ arena but the Obama camp declined that offer. So to make it clear, UVA didn't snub anyone.
Ahhhh .... @OMGitspaul, you clearly did not attend/graduate from UVa. We don't call it "Campus," bud. It's called "The Grounds." Now, I anticipate you and everyone else will respond by calling me an arrogant snob. Fire away!
here is the text of the speech...
Good Afternoon Charlottesville.....
Did everybody get some koolaid? Drink up.... its free ... well sort of, I did bill it to the taxpayers like all my vacations and golf games.....
Joe Biden couldn't be here today... he is suffering from a little "foot in mouth" disease, but I am sure he will be "unchained "within a few days...
As I look down this downtown mall and see thie sides lined with able bodied homeless people, I want you to know that starting in 2014 we will be giving them all "obamacare" addition to the food stamps I already extended their way... so once they can lie about back pain and get vicodin for free,you won't need to give them as much money for drugs when they panhandle.... thats how I roll!
As I look off to the west towards UVA I can see "Westhaven," the high rise where people have been living free since the 1960s when urban renewal taxed the rich and built that for them so they could have a place to live while they looked for work... I want you to know that this 50 years of free rent is NOT at risk with the "welfare to work" rules... we found a loophole through the use of housing grants.. so just like the food stamp program and obamacare, these poor people won't have to deal with the indiginty of having to earn a living working for people who are more succesful then them. Think of it as their "participation trophy"
and as I look past Westhaven I can see UVA.... the University built through the hard work of Thomas Jefferson... and I think back to that moment in time where a local guy "Jack Jouette" made his famous ride through the woods where no trails existed, to warn Jefferson and others that the British were coming... ...and I want to take a moment here to point out that although he gets the credit... Jack Jouet didn't "build that" on his own.... in fact if it were not for the British GOVERNMENT trying to Jack up taxes and intrude in the private lives of citizens with the quartering act there wouldn't have even been a war in the first place... so make sure we give proper credit where credit is due.... but back to UVA, ..... I know that there are a lot of smart kids over there who need our help.... they are the victims. They have been poisoned by a public school system that forced them to say the Pledge of Alliegance and to stand for the Star Spangled Banner, some of them actually had to endure "christmas " parties. They need our help. It is unfair to expect them to make it through college without student loans that can be left unpaid, it is unreasonable to expect them to have to use a complicated laptop and software when all their predessors had to do was learn how to use a manual typewriter, a protractor and slide rule. The youth of today have it so much harder. In 1965 all students had to do was sort maybe 50 record albums, in todays dorm their ipod might have 2000 different songs, they have to navigate through you tube videos, cat memes and 100s of porn sites.... it is so unbearable that it has caused many of them to binge drink from the pressure.... Well I am here to say today that if I am reelected I will EXPAND government with all kinds of new programs to give these kids a government job so that they don't have to work so hard and actually learn anything because they will all be working for ME.
I also would like to announce a new program like Obamacare but for cars.... I call it "Obamacar" ... we wil issue everyone (except the rich of course) an auto repair card, where you will be able to bring your car in for service to any shop you want and the government will fix anything and everything on the car by taxing the rich and borrowing more from our friends in china. We will also help pay for this program by putting a tax on all mechanics tools, and a surcharge on any parts they use. These fees of course will be charged to the repair shop and not the consumer.
In closing, I would like to say that I know the Republicans say that my vision for America is financially unsustainable, they will try and confuse you with facts, like taxing the rich will only cover 8 days of my overspending and that I have no answer for how to deal with the other 357 days. They will tell you that I golf too much, and that I lied about the true cost of obamacare... they will tell you that Mitt Romneys tax returns should be less important than my college records and papers that I spent millions to conceal, They will tell you that my passport and unexplained trips to the middle east when I was younger should be fair game as should be who actually paid for my college and ... They will try and confuse you with facts like I am spending MORE in Afghanastan than George Bush ever did, that I didn't close gitmo as promised, that I gave GM to the Unions... well I am here to say none of that matters because I KILLED BIN LADEN WITH MY BARE HANDS...... So the choice is clear.... vote for me and get more free crap at your grandkids expense or vote for Romney and have to get up and go to work everyday.....
The real story is that the length and cost of campaigning is out of control and everyone is sick of it - and it's still August.
We need to change this .
Campus/Grounds who cares? ***yawn****
It's kind of like, "Is it an ottoman or a footstool?"
After the Sullivan fiasco UVA is more like a footstool stuck in the Grounds.
I'm proud of UVA for making the right decision.
felonoius munk has weighed in on the campaign,,,
I want this election to be over for hundreds of reasons, but the most important reason is that after November I will no longer have to read Bill Marshall's twaddle about the 8 days.
deleted due to possible insult
If our law makers truly cared about the economy why wouldn't they direct all campaign contributions to efforts to put people back to work - why would they stress cities and towns around the country with campaign events that take security workers away from their normal jobs and disprupt the local economy - not to mention the cost ?
This is not directed at any one party but at All elected officials .
One month of this would be plenty. I am looking for a candidate with the common sense to end this insanity .
Guessing this 500K plus for cville is coming out of the taxpayers pockets.
@OMGItsPaul...Did you not hear the UVa situation? Obama asked for one of two locations right on campus (I don't subscribe to that "Grounds" BS either). The college refused due to many factors (cost, disruption, cancellation of classes on what for many is the first day of school). They offered JPJ. Obama refused, saying it was not "academic enough." Really, they did not want the pontiff seen speaking in a 1/5 full venue.
So, Obama selected the highly academic nTelos Capshaw Memorial Pup Tent...real classy, eh? Why didn't he approach PVCC? That is an educational venue and a prime location to tout the need for post-high school education (be it academic or trades).
Therefore, whilst you'd like Obama to plead martyrdom by saying he was "snubbed," it was his arrogance that kept him from UVa.
Sully was spot on with this call!
R.I.P.: Wilt Chamberlain
(1) I love you, Bill Marshall.
(2) And to the Obama campaign, what's wrong with JPJ? It was good enough for the Eagles, Dave Matthews, Jimmy Buffett, etc., etc., and if I'm not wrong, Paul Tudor Jones has ante'd up some $$$ for Mr. Obama. Maybe it's because the few thousand people who are showing up would look like BBs in a boxcar in a large arena.
(3) UVA made a fair and square offer. Get over it, you complainers.
(4) Give me a pad and pencil to count the welfare cheats, foodstamp frauders, etc. I agree with Dennis Miller . . . I'm happy and willing to help the homeless. I'm just sick of helping the clueless.
Ha Ha, typical white people running scared from a black president. Naw, I'm just messin wit you. Y'all should've seen Between Barack and a Hard Place at Live Arts this weekend. It was the creamy dessert to the full meal that is the presidential elections. It was talking about issues that people were really concerned about like diversity and how if we can all laugh at black comics then we can all laugh at the same things because if we don't diversify then our nation is all but contigulated.
People waited in long lines for underwear in the Soviet Union too.
Jeez, you all are touchy.
Bill Marshall- You're all mad because you say Obama says he killed Bin Laden with his own bare hands. But obama never said that, so why get so upset about something that never happened? You should be more upset up facts like the fact that Bill Marshall has a dog turd for a brain. Naw, I'm just messin' wit you.
You shoulda checked out Between Barack and A Hard Place at Live Arts this weekend. It could have given you a good look at politics from a hip hop point of view.
UVA couldn't handle the Presidential Protection with campus cops. Just sayin ....
If it was a Republican President, the University would have been honored.
Tinkerbelle, if the president had been white UVA would've been honored. Let's not beat around the bush. Sullivan is already close to being fired, she don't need to be letting blacks on campus to talk. This actually came up in Between Barack and A Hard Place and the hip hop president gave a great answer about race, diversity and healing wounds.
Tinkerbelle . . . the UVA Police Force (officers of which are probably clearly more intelligent and well trained than a lot of the posters on this site . . . )
And Ty Cooper . . . what about this story don't you get . . . what the h-ll is wrong with Scott Stadium or John Paul Jones? The offer was made. It was rejected. There has to be a rationale behind the Obama campaign. This is not about Ms. Sullivan.
Of course Lynne, black president so we'll let him talk at one of our sporting venues? Typical slave owner mentality, blacks are good enough for our sports teams but when they want to be on the lawn? Oh no, that's massa's territory.
You probably could've used some time at Live Art's Between Barack and A Hard Place this past weekend. The hip-hop president would've presented you with a view other than the priviledged white one you currently own.
I am glad he is not coming to UVA. UVA is more than just an institution of higher learning. We have a major hospital here, folks, with people coming in for surgery, cancer treatments, office visits, etc.
All these road closures make it difficult for patients and staff to get to the medical center. We are disrupting thousands of people when you consider the school closures, downtime and revenue loss for businesses along the closed streets, CHO,etc. The city and county have to provide security which is costly. And this is in exchange for what? We will have a few extra people in town, eg reporters and the DNC officials boosting the restaurant and hotel businesses for a day or two, and the Secret Service looking for companions, otherwise, just an inconvenience. He isn't coming to Cville as President. He's coming to beg for votes, no more, no less. He wanted UVA students, not just any college students, because he heard about the Sullivan mess and thought UVA students would loyally support him the same way that came out in large numbers for her.
The news media should stop dreaming about the masses coming to see him; they still have tickets left that they can't even give away.
The president refused to pop his collar, and therefore was denied access to "Grounds"
(It's a campus, people. Get over yourselves.)
Ty Cooper . . . there's no way to reason with people who see racism everywhere. How about the white exterior of the UVA Hospital? Or the white lines on the highways? Or the background on this Hook page--it seems a little too white. Obviously, this is a silly topic--so don't even remind me. We'll all live in a better society when we're all color blind and not looking for a racist reason behind every decision. We are better than this.
Buzzbomb re: "Grounds" versus "campus" . . . I'm guessing your application was denied. Practically every college/university has a distinguishing characteristic of tradition . . . it's really not that big of a issue.
Lynne, if you can't see the obvious message sent by only allowing the black president to speak at the atheltic facilities then I can't help you.
But you're employing a classic white devil maneuver- instead of answering the questions, obfuscate and confuse with illogical ruminations.
Like I said earlier . . . there's no reasoning . . . I give up!
And when your charlitanism is revealed, retreat. Straight out of Saul Alinksy. Nicely played Lynne, right out of the bigot's handbook.
I don't think there should be any Black v. White stuff. Isn't the president a mixture of both? Just asking.....
Ty, the Democratic Convention is going to be in a sports stadium.. are all those Democrats bigots too?
Obama 2012: Continue the failure.
Ty . . . I guess you meant charlantanism, not charlitanism . . . I'm neither a fraud nor a fake . . . just a grown-up.
Bill, a (D) after your name don't take the racism from the game.
Lynne, I didn't realize you were the official editor of the internet. Somebody is mixing up 'your' and 'you're' over on Facebook, better head on over.
Obama 2009: Failure
Obama 2010: Failure
Obama 2011: Failure
Obama 2012: Failure
No PhD in Computational Statistics needed to see a pattern here.
Apparently, the Obama "planners" didn't do a very good job planning this particular trip. Not a lot of forethought or expertise involved and certainly not a lot of "caring" for his voters. PCC would have been a better site, for this particular time of year, considering our school children, UVA students, UVA Hospital and Martha Jefferson patients and senior citizens. Obama, meet with your planners and do a more thoughtful job next stop. The rest of us have jobs on the downtown mall and surrounding areas and now we have a pay cut AGAIN!
Let's just hope he does for HIS re-election campaign what he did for Tom Perriellos' at this location !
@Liberalace...I know man, I get it. I'm just saying that it should be viewed as an honor, not an inconvenience for any president to speak at any school anywhere in this country. Obviously there are folks that don't agree with that...not my problem.
So many butthurt people commenting. Go back to Lynchburg.
he wants uva because the campaign is once again targeting the youth, who are adrift in a fantasy world of no taxes and no consequences while mom and dad pay their tuition to drink, bang, and eat at the dining hall. College is the ultimate socialist experience for the student. And that only applies to the average student- Uva dominates the snob out of touch attitude.
Do we really want our President to be chosen again by folks whose frontal lobes haven't fully developed ?
It's great when folks like "tony stark" post. He SO exemplifies the snotty, elitist, liberal mentality where you look down your nose at others (like people who live in Lynchburg) and think they're all too GD stupid to make their own decisions. They need government mandates and programs to survive.
With all of the other comments being made about Obama's visit to Charlottesville, I would like to add the following.
I was in Charlottesville today (29th) having two appointments in Charlottesville, I arrived in Charlottesville at about 10:45AM and left about 3:15AM. I would like to comment about the number of police in Charlottesville today, at most intersections on Route 29, Rio Road and down Route 250 there was at least one police officer and in many cases as many as three officers, all with their engines running and lights flashing, sitting in their cars and doing nothing. Also there were many police cars setting in parking lots at places such as McDonalds, and many other fast food joints. At one point I saw an accident on Route 29 with two police cars not 25 feet away and the gentleman driving the car was on his cell phone calling (I presume 911) the police officers were setting in their cars doing nothing, at this time.
I counted over 100 State Police cars and what looked to be most all of the Albemarle County Police cars, plus most of the City and county sheriffs vehicles. In addition I also saw many heilcopters (not sure how many) flying over Charlottesville, and these are not cheap to operate.
What I would like to know is how much all of this cost the taxpayers in restuarant bills, fuel costs, overtime for the officers and costs to private citizens who had to sit and wait for this event to take place, not to say anything about the fact that about 3:00PM when I left CHarlottesville all of the major thruways were closed to traffic.
I am in agreement with several of the people above who thought that this event should have taken place at PVCC, Mr. Obama could have been landed at the school without all of the streets being closed to traffic. What would have happened if someone had to be transported to the hospital by rescue while all of this was going on?
My personal feelings about this is that these costs should be billed to the DNC for payment as I don't believe that the taxpayer should be responsible for these costs.
A desperate ploy for votes from people who are already going to vote for him.
I would imagine if we added up the money spent and divided it by the new votes he may have garnered with his rhetoric it would come close to 500 bucks a vote.
somebody needs to tell him that spending benjamins like that does not qualify as a "green " job......
No wonder he can't create a job for less than 300k.
Obama a failure? Stock market at 7500 and now 13000. It's been great for us investors. Isn't that whom the GOP is supposedly supposed to be for? You know, those investors who create lots of jobs?
Oh, and all the tickets were given away. 3500 tickets 3500 in the tent and another 4000 on the mall gathered to listen. 7500 people. Sounds like a pretty solid rally to me.
The stock market is showing profits because companies are sitting on cash which makes them "healthy" That unfortunately is the result of companies not taking risks or expanding for more growth ... which is what we actaulally need. So you are correct that there are currently some companies who are good deals because of their healthy balance sheets, but conservative healthy balance sheets seldom yield the gigantic growth needed to help with the lack of employment. These cmpanies wil continue to sit on this cash until they see a light at the ned of the tunnel that is not the obamacare and government regulation freight train.
If you heard a rumor that Virginia was going to triple the car tax to pay for whatever would you run out and buy a new car ot think twice? If Virginia were to make the car tax 1.00 for the first two years on any new car bought in 2012 would you at least think about whether it might be a good time to take advantge and replace the hooptie in the driveway?
... and the car thing is a good example of Obamas failure.... if the car tax forgiveness were implemented people would trade in cars, allowing the trickle down economics to kick in so everyone in the chain could move up a notch and the deathrap could be scrapped. instead obama had cash for klunkers and took a million or so decent cars off the road and created an artificial shortage driving used car prices UP in a recession instead of down. putting a burden on the very people he proclaimed to help. He scored points with the greenies and fooled some peole inmto thinking it was a sound economics program but like almost everything he sticks his nose in he screws it up.
as for the number of people at the rally, C-ville is a liberal city with a liberal University. 7500 is a nice turn out but itt appears that Mark Twain was right.... "get the fools in town on your side.. thats a majority most anyplace"
@Ty Cooper - contigulated?? Don't you mean contagenated?
Now that it's over ... it went well, didn't it?? And the real reason the President of the United States didn't speak on campus .... Gov Bob McDonnell. The Republican Convention needed Bob McDonnell and he was not about to let Obama speak at his Flagship University while he was tending to business in Tampa......
@bill marshall, amusing speech. Thanks for taking the time. However, I was told that many blacks labored at UVA for its building.
@Ty Cooper, blacks have lived on the lawn through years so I doubt if there was any objection to the President's speaking there because of his race. Also, if you can use "white devil" is it also okay with you for me to use "black heathen?" Please come to see my production next weekend at Live Arts called "Romney, Obama and A Bout of Constipation."
@Geek, there was a time when over 12,000 buttons were SOLD for First Night VA so 7500 freebies is not that impressive.
@Bill, I think the candidates' campaigns should pick up the tab. If the DNC or a superpac wishes to kick in, fine. He was not here to conduct the business of government. He was here conducting his own personal business of getting re-elected.
@NancyDrew, campaigning has become a year-round billion dollar industry that is providing tons of jobs and is pumping a lot of money into the economy. Let the money continue to flow from the fat cats. It's not as though I can't use my mute button when watching TV. I hope they send my more junk mail. USPS can use the business.

subset: commoncrawl


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NORFOLK, Va., Oct. 4 (UPI) -- Former U.S. Secretary of Defense Robert Gates said a military attack on Iran could "prove catastrophic."
Gates -- who headed the Pentagon during the administration of former President George W. Bush and remained at the post when Barack Obama became president -- said America and Israel lack the capability to wipe out Iran's underground facilities permanently, and an unprompted attack would ensure a nuclear Iran eventually, after the country digs its labs deeper underground and redoubles its resolve, the (Norfolk, Va.) Virginian-Pilot reported Thursday.
"The results of an American or Israeli military strike on Iran could, in my view, prove catastrophic, haunting us for generations in that part of the world," Gates said Wednesday in a speech in Norfolk.
He urged U.S. diplomats to make clear Israel does not have a "blank check" to attack Iran unilaterally.
Instead, Gates said the United States and Israel should pursue economic sanctions and international isolation, which he said will convince Iranian leaders to abandon their nuclear ambitions.


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Luisa Hector PhD, CFA
Credit Suisse
[email protected]
Roche reported solid 1H12 figures with a sales beat and EPS in-line plus a reiteration of FY12 guidance. Key drugs and emerging markets all showed strong growth in 2Q12, and pharmaceuticals saw underlying sales growth of +6% (vs. +2% in 1Q12, +3% in 4Q11, 0% in 3Q11).
Roche benefits from a very limited patent-expiry burden in 2012-15E. Whilst some investors seem concerned about longer-term threats from bio-similars, Roche has multiple strategies in place to protect its core franchises. We believe that this defensive outlook should underpin Roche's ability to return incremental cash to shareholders in the form of dividends (circa $31 billion of [free cash flow] remains unallocated from 2012-15E).
Karen Andersen, CFA
[email protected]
Roche's top line grew 4% at constant currencies in the first half to reach Swiss franc 22.4 billion (US$ 22.9 billion), and the firm's core EPS grew 8% to Swiss franc 6.94 (US$ 7.10), as costs of goods sold remained flat due to lower manufacturing costs and lower royalties owed for declining products like Tamiflu, CellCept and Boniva.
In the pharmaceutical division, sales grew 4%, thanks to strong growth in the U.S. (6%) and other international markets (8%), despite a 3% decline in European sales, where continued growth of key cancer blockbusters Herceptin and Rituxan was countered by generics pressure and a 2% impact of pricing pressure.
As the market leader in both biotech and diagnostics, Roche is in a unique position to guide global health care into a safer, more personalized, and more cost-effective endeavor. Key acquisitions, such as Ventana Medical and Genentech, complement this firm's innovative offerings, and we're confident in the sustainability of Roche's competitive advantages.
Michael Faerm
Credit Suisse
[email protected]
Bottom line: Watson Pharmaceuticals remains our top pick. We continue to like WPI, because it has a superior growth profile among major generics companies, driven by a generics business with a favorable product mix characterized by several non-commodity products that bring better margins and durability than standard generics.
The pending Actavis acquisition is compelling strategically and financially, as it transforms WPI into a global generics leader with new strength in attractive markets, bolsters long-term growth and creates substantial value.
Concerta [competition] assumed in early 2013 has modest impact given margin step-up and likely quota constraint: We model a generic entrant (presumably Kudco) at the beginning of 2013. We assume that an entrant would face supply constraints due to limited quota availability, and consequently would take volume share slowly and thus have little incentive to price aggressively.
Michael Waterhouse
[email protected]
Following its acquisition of Actavis, Watson will become the world's third-largest generic drug manufacturer. The deal brings numerous potential advantages to Watson's operations, including a global footprint, enhanced economies of scale, access to attractive, fast-growing emerging markets, and additional manufacturing capabilities with injectable, transdermal, and liquid pharmaceuticals.
We think this acquisition strengthens Watson's economic moat and follows a list of well-executed drug launches, including Concerta, Lipitor, and Lovenox, which have produced attractive returns on capital. While integration efforts, a higher debt load, European pricing pressure, and the patent cliff remain concerns, we think Watson has entrenched itself as a heavyweight in the generic-drug industry. Down the road, we expect management will focus on acquisitions to bolster vertical integration and the branded drug pipeline.
We continue to think Watson's portfolio and pipeline of limited competition generic products offer greater future earnings clarity, and combined with the company's branded segment, bio-similars agreement with Amgen, and soon-to-be acquired international operations from Actavis, Watson remains one of the best positioned generic drug manufacturers, in our view.
Edward Nash
Cowen and Company
[email protected]
Inovio Pharmaceuticals focuses on the development of therapeutic and preventive vaccines for the treatment of cancers and infectious diseases that have a major medical need. The company has strong scientific expertise in the discovery and clinical development of vaccines by employing its proprietary SynCon plasmid technology for the composition of the vaccines and electroporation for the delivery. Inovio's lead program, VGX-3100, is in Phase II clinical development for HPV infection.
Inovio's business strategy is to partner the vaccine programs with strong companies that look to make Inovio's vaccines a clinical priority and to create partnerships that maximize shareholder value. We believe that by focusing on therapeutic areas where there is a major need for new therapeutic and preventive vaccines, Inovio and its partners help to de-risk their interactions with the FDA.
Inovio's proprietary plasmid technology and delivery method are differentiated. We believe Inovio's plasmid technology, bundled with its electroporation technology, sets it apart from other DNA vaccine developers. This technology combines strong immunogenicity with a convenient and effective delivery method that is able to get Inovio's vaccine into cells and provide novel therapeutic options across a diverse set of indications.


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Keith Koffler
January 12, 2013
As a state senator in Illinois, President Obama opposed legislation providing an exception to handgun restrictions if the weapon was used in the defense of one's home.
Obama's vote would have maintained the status quo, which made it a violation of municipal gun ban law to use a firearm to save your own life in your own home. But the bill was passed anyway without his support.
The vote is a sign of how committed Obama may be to strict gun control measures.
The Illinois vote is hardly ancient history, having occurred in 2004 as Obama was running for election to the U.S. Senate. In opposing the measure, Obama lined up well to the left of the mainstream, as the Illinois Senate included 32 Democrats to 26 Republicans but approved the bill by an overwhelming margin and subsequently overrode a veto by then-Gov. Rod Blagojevich.
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Archive for December 10th, 2012
madness born
"follow" me on Twitter at @newtownpentacle
– photo by Mitch Waxman
It might be a bit of an oxymoron to say this, but there has been a lot of oil floating in the Dutch Kills tributary of the Newtown Creek since Hurricane Sandy. Realize who this statement is coming from, of course, and the unhealthy familiarity with this waterway which I enjoy. Dutch Kills is one of the forgotten parts of the creek, mainly because it is in Queens.
Mayan Apocalypse Countdown: just 11 days left until the 13th b'ak'tun ends, initiating the Mayan Apocalypse on December 21st. Tick, tock.
– photo by Mitch Waxman
One is often faced with a quandary regarding the Newtown Creek's northern bank. The Brooklyn, or southern side is well monitored by an army of concerned observers, whereas it often seems that the Queens side only has me. Relying on one such as myself is a terrible idea, given my onerous personality and irksome inability to fulfill even simple responsibilities like doing the laundry.
– photo by Mitch Waxman
Photographic records which I have been building for several years of this canal also reveal that the water has never been observed with this particular coloration before, which is obsidian. Something has changed here, possibly of a chemical nature. Perhaps the Bowery Bay sewer plant, whose out falls are found along this stretch, was impacted deeply by the storm? I have no answers to offer.
I guess it doesn't matter, who cares about Queens anyway?


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Funeral for Whitney Houston is Saturday
(CNN) -- Family and close friends will say goodbye to Whitney Houston with a private funeral and burial Saturday in her native New Jersey, trying to come to grips with grief that the pastor of her childhood church called "very deep."
"We are all hurting," Pastor Joe Carter of New Hope Baptist Church in Newark told CNN's Jason Carroll on Tuesday. "That voice is silenced. But she left us with so much."
Earlier in the day, Carolyn Whigham -- the owner of Whigham Funeral Home in the northern New Jersey city -- said that Houston's funeral will start at noon Saturday at that church.
Carter said that he'll officiate what he described as a "small ... invite-only service." The church seats a maximum of 1,500 people, and the pastor said he expects "all these empty pews to be filled with people whose hearts are broken."
"She was able to leave us with so many wonderful memories of that God-given gift," he said. "That's what we are celebrating on Saturday."
At the request of the late singer's mother Cissy Houston, the eulogy will be given by Marvin Winans, a gospel singer and pastor at Detroit's Perfecting Church, Carter later told CNN's Erin Burnett. Winans officiated Houston's 1992 marriage ceremony to R&B singer Bobby Brown.
New Jersey Gov. Chris Christie told reporters Tuesday that he planned to issue an executive order so that flags at government buildings throughout the late entertainer's native state would fly at half-staff on the day of her funeral.
There will be no large-scale public memorial in Newark in the immediate aftermath of Houston's death, city spokeswoman Anne Torres said. The funeral director at the Whigham Funeral Home told city officials that the family did not want a big memorial, according to Torres.
Carter, the New Hope pastor, said organizers hope to set up a large screen outside his church, so people who cannot get inside can see the funeral proceedings.
The pop superstar's body was flown to New Jersey's Teterboro Airport from California on a private plane belonging to filmmaker Tyler Perry, according to a law enforcement source with knowledge of the situation.
Late Monday, her body arrived at the Whigham Funeral Home -- borne by a hearse and escorted by police -- as a large crowd looked on. Cissy Houston, the late singer's mother, was waiting inside, police said.
New Hope's pastor described Cissy Houston -- herself a well-known gospel singer who was active at the church -- as a "strong, strong woman."
"Her heart is broken: Nobody expects to bury her child," Carter said. "But she is managing it with miraculous strength. She is so grateful for prayers and thoughts, and that's holding her together."
Whitney Houston, 48, was found dead Saturday in her suite at the upscale Beverly Hilton, just hours before she was scheduled to attend a pre-Grammy bash at the hotel.
Why she died remains a mystery.
Despite widespread media speculation, a Los Angeles County coroner official Monday downplayed the suspicion that drugs played a major role.
Assistant Chief Coroner Ed Winter said that "not many prescription bottles" were found in the singer's room after her death. The amount of medications recovered by investigators was less than what is usually present in deaths attributed to overdoses, Winter said.
"I know there are reports that she maybe was drowned or did she overdose, but we won't make a final determination until all the tests are in," he said.
Winter ruled out foul play and said there were no injuries to Houston's body.
The singer's soaring voice and impressive talent had taken a back seat in recent years to her struggles with drug addiction.
However, a close family friend who was also at the funeral home told CNN's Deb Feyerick on Tuesday that Houston was "no longer an addict," meaning she was no longer using "hard drugs." The friend said Houston was taking medication for a throat infection and Xanax for anxiety and to help her sleep. And it was not uncommon for her to have a drink when she went out, he said. The friend asked not to be named because of the sensitivity of the situation.
"She had let it go," he said. "And we were proud of her."
He said he had seen Houston about two weeks ago in New Jersey, and she told him, "I'm at a comfortable place in my life."
The friend said Houston had been "clean" from hard drugs for three years and had not used cocaine or marijuana, and added that her family is upset by media coverage focusing on her history of drug problems.
"In her life, she made some bad decisions, but let's not forget the good ones," he said, recalling how she returned to Newark at Christmas and gave to those in need. "... She took care of foster children, and children with AIDS."
And a singer who participated in an impromptu duet with Houston at a party Thursday night said Houston was not behaving erratically.
"I didn't see someone who was high," Kelly Price told CNN's "Starting Point" on Monday. During the party, Houston took the stage unexpectedly and sang a hoarse rendition of "Jesus Loves Me" with Price.
Whitney Houston: A mother, a daughter, a friend
Houston's body was released to her family Monday, a day after an autopsy was conducted in Los Angeles.
Winter, from the coroner's office, said that results of toxicology tests could take six to eight weeks, though Beverly Hills police Lt. Mark Rosen said Tuesday that the coroner's report is expected to be finished sooner -- in two to three weeks. That report's conclusions into what Rosen now describes as an "unattended, unexpected death" will drive what investigators do next, the police spokesman said.
Beverly Hills police have requested a "security hold" on the coroner's report, a common practice in high-profile cases that limits what can be revealed about an investigation while it is ongoing.
Reverend: The Whitney I knew
Asked how long Houston had been dead before she was found, Winter said she only that she was seen alive within an hour of her death.
Houston's body was found by her assistant, Mary Jones, who was often called "Aunt Mary," a family source said Tuesday. Earlier, Winter had confirmed reports that the songstress was found in the bathtub of her hotel room.
Houston's 18-year-old daughter, Bobbi Kristina, was in the care of her grandmother Cissy and her father, Bobby Brown, the close family friend said Tuesday. Houston and Brown divorced in 2007.
Brown released a statement Tuesday saying his daughter, after a "visit with doctors at Cedars-Sinai Medical Center in Los Angeles on Saturday," is now "with my family, including her (half-) siblings."
"Obviously, the death of her mother is affecting her," said Brown, known as a member of the group New Edition. "However we will get through this tragedy as a family."
LZ Granderson: Sad, but no shock
On Monday night, Aretha Franklin -- the singer known as the "Queen of Soul" and Houston's godmother -- honored her at a concert in Charlotte, North Carolina, according to CNN affiliate WSOC.
Franklin called Houston "one of the greatest singers that has ever stood before a microphone," and sang Houston's smash hit song, "I Will Always Love You," the station said.


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Do You Need to Clip Your German shepherd Dog During Summer?
Summer is a season that puts wrinkles in the forehead of German Shepherd Dog owners. Many GSD owners – especially the new comers tend to clip/ trim their dogs' coat, thinking that trimming would make their dogs' life comparatively comfortable in an extreme environment where the outside temperature is much higher the body temperature.
Fact is that you should NOT trim your dog's coat in the hot weather season. The body temperature is radiated out via panting, not through the skin, unlike humans. For human the sweat is evaporated on the skin surface, and the process acts as a cooling mechanism. But for your dog, evaporation doesn't happen on surface of its skin, and air circulation, hence, is not much important on the skin surface. Trimming or clipping hair is not necessary. Remember a trimmed German Shepherd faces tougher times during summer than its untrimmed counterpart. Coat acts as an effective insulator against environmental heat. If the environmental temperature is warmer than the body, then the body gets heated up faster if the insulation is removed.
German Shepherds, like any other canine breed, have thinner layer of coat in their inguinal region. Whenever they have to cool down they would lay on cooler surfaces with the region exposed to the surface. This way they would help themselves to radiate off their body temperature.
So, it is recommended not clipping your shepherd's coat during the summer. Keep him in a cooler place inside that is airy. Natural thermoregulation through panting allows a dog to drop his body temperature. However, brachycephalic dog breeds (breeds with broad, short head like Boxers, Pugs, Bull Dog, Boston Terriers, Shar Pei, Cavalier King Charles Spaniel etc.) do not pant effectively. This, consequently, leads to insufficient thermoregulation, which over heating during the hot summer days.
Mesaticephalic or Mesocephalic dog breeds (breed that have intermediate length and width of head such as German Shepherd Dogs, Dalmatian, Cocker Spaniel, English Foxhound, English Springer Spaniel, Field Spaniel, Labrador, Komodor etc.) can thermoregulate through panting better than the brachycephalic dog breeds. Hence they have comparatively lesser chance to get overheated during summer.
On the other hand the dolichocephalic dog breeds (breeds that have long slender head like Afghan Hound, Great Dane, African Azawakh, Borzoi, Chart Polski, Galgo Español, Greyhound, Hortaya Borzaya, Irish Wolfhound, Italian Greyhound) are least prone of get overheated during the summer, because they pant most effectively. However, whatever type of breed you own, it is important to keep your dog in cool place, with making fresh water readily available. And it is one worst idea to trim GSD's hair in the summer.


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Robert Browning#42 on top 500 poets
» Click to list general statistics » OR, select a date :
Glove, The
(PETER RONSARD _loquitur_.)
``Heigho!'' yawned one day King Francis,
``Distance all value enhances!
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- Home
- Government
- City Council
- About the City Council
About the City Council
- 5:30 p.m.
- The 1st, 2nd, and 4th Tuesday of each month
- 1010 10th Street
Lower Level
Modesto, CA 95354
Agendas & Minutes
View the City Council Agendas and Minutes.
- Mayor Ted Brandvold
- Mani Grewal, District 1
- Tony Madrigal, District 2
- Kristi Ah You, District 3
- Bill Zoslocki, District 4
- Jenny Kenoyer, District 5
- Douglas Ridenour, District 6
Responsibilities & Purpose
The Vice Mayor is elected from among Council members by a vote of City Council.
The Mayor of Modesto is the presiding officer of all City Council meetings and is authorized to sign legal documents on behalf of the City. He represents the City on local, state and national levels. In his absence, his duties are performed by the Vice Mayor.
The Modesto City Council is the City's legislative body. It sets policies, approves budgets, determines tax rates and passes ordinances and resolutions to govern the City. Council also appoints citizen volunteers to more than 26 City advisory boards, committees, and commissions; and appoints and supervises the performance of the City Manager, City Attorney and City Clerk.


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I would like to create a service or background running program (something that minimizes to system tray).
It would have a path list of external applications, eg.
- C:\App1\Task1.exe
- C:\App2\Task2.exe
- C:\App3\Task3.exe
It would start the first one and monitor the process details (CPU Usage, Mem Usage, and maybe I/O Writes). Each application will do their jobs for a couple of minutes then go idle - hence completed the task. At this point the CPU Usage = 0, Mem Usage, etc. will be idle.
Then I need to close/kill that process and start the next application in the list. And this repeats as above and so on.
Does anyone know how to execute an external program, monitor the process details, then kill it?


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Tejada proving to be a solid reserve for Royals
NEW YORK -- Miguel Tejada may have turned 39 years old in May, but he hasn't shown his age on the field. The former American League Most Valuable Player has extended his career by learning to play as a reserve, and he's batted .292 entering Tuesday and provided solid defense at both second base and third for the Royals.
That resurgence comes after Tejada essentially missed an entire season. The veteran played in 36 games last year for Triple-A Norfolk in Baltimore's organization, and prior to that, the last sighting of him in a big league uniform saw him hitting .239 in 91 games for San Francisco in 2011.
Now, the former Iron Man has recast himself as a substitute. Tejada, who put together the fifth-longest consecutive-games streak (1,152) in history, hasn't played at his former position of shortstop. But he's given the Royals enough that even manager Ned Yost is a little bit surprised.
"Maybe a little bit. But he's a very experienced player," said Yost. "He knows how to play the game. He knows how to prepare. He knows how to stay ready and he knows how to produce."
Tejada, the 2002 AL Most Valuable Player with the A's, is a long way away from the guy who drove in 150 runs for Baltimore in 2004. But Tejada has homered twice for the Royals, and he went into Tuesday's game against CC Sabathia batting .302 off left-handers this season.
"He hasn't really slowed down that much. He plays with a lot of energy," said Yost. "But yeah, it's been a little surprising how well he's played. He hasn't played shortstop yet. He's been playing second base and third base, and he's done well at both positions."


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Our company started as UV flatbed printer which only focus on flat-bed inject color printer and industrial UV relief color printing machine production for over 10 years. After all the experience we were extremely professional in providing high printing efficiency to the customers. We specialize in the production for the flatbed inject color printer and industrial UV relief color printing machine. Our products are in strict accordance with ISO9001 systems and CE standard for quality management to orientation, which lead to the high printing efficiency of 15 square meters per hour, high resolution and perfect printing effect.
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text: I have a 04 330 ci/41,500 mi. and I will in the near future be replacing the brakes. I will be assuming that I will need to replace the rotors at this time. I believe I do not need to repalce the the calipers. 1) I would like to replace the rotors with drill/slotted ones. What manufactuers would be recommend by club menbers who have made this change? 2) What pads would be recommended for this application. Thank You for your input. firstname.lastname@example.com


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Red and Green Plaid Organic Baby Harem Pants, Leggings.
Super Trendy Baby Harems in a festive Plaid print, perfect for the holidays.
The Details:
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*Sizes from Newborn to 3T
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ENTER MY SHOP HERE to see more: www.etsy.com/shop/villagenorthbaby
***Copyright © 2017 by Village North Baby
All rights reserved. Design, Description and Photography is the sole and legal property of Village North Baby. Do not copy or distribute any part of this publication without prior written permission from Village North Baby.
3-5 business days
I'll do my best to meet these shipping estimates, but can't guarantee them. Actual delivery time will depend on the shipping method you choose.
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But please contact me if you have any problems with your order.
Gift wrapping is included with every order.
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I do not offer wholesale at this time.
Sizing is explained within the item details. If you have any further questions, I'm happy to help.
Everything is handmade to order just for you. I can not accept returns, exchanges or cancellations. Please contact me if you have a problem with your order. Thank you.


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Matchbox 20 - 3 AM Notes
Voice. Includes 5 page(s). Genre: Rock. Download or print Matchbox 20 3 AM sheet music notes, chords in minutes. Check if it is transposable. SKU of the score is 182858.
* Where transpose available (not all our sheet music can be transposed) & prior to print. **You must have appropriate converter installed. One can either print or convert. *** Selected by our editorial team.
- Additional Information
Additional Information
Genre Rock Arrangement Voice Number of pages 5 Price $5.99
- Reviews


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BRYN MAWR, Pa. - Rock musician and writer Patti Smith is being honoured by Bryn Mawr College with a medal named after the late actress Katharine Hepburn.
Smith received the 2013 Katharine Hepburn Medal on Thursday night in a ceremony at the women's liberal arts school in suburban Philadelphia.
Smith is recognized as a rock 'n' roll trailblazer whose work as a musician, writer, performer and visual artist influenced multiple generations. Her 1975 debut album, "Horses," is considered one of rock's greatest albums and she received the 2010 National Book Award for non-fiction for her memoir, "Just Kids."
Smith said when the college approached her about receiving the award, "I enthusiastically accepted without hesitation."
"Bryn Mawr is helping shape the futures of young women and providing them with the tools to be dominant forces in our society," Smith said.
College President Dr. Jane McAuliffe said Smith "conveys enormous passion and continues to transform herself throughout her artistic journey."
The college comprises 1,300 female undergraduates, two co-educational graduate schools and a co-educational pre-medical program.
The medal named after Hepburn, a Bryn Mawr alumna, honours women who change their worlds and whose work and embodies the intelligence and independence of the four-time Oscar winner.
It was awarded by the college's Katharine Houghton Hepburn Center, which memorializes Hepburn and her mother, an early feminist activist who share the same name, with programs focusing on the arts and theatre, civic engagement, and women's health.


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Athletic Director Terry Mohajir receives key to city of Mobile
MOBILE, Ala. – Arkansas State Director of Athletics Terry Mohajir and interim head football coach John Thompson participated in a press conference Wednesday night held right before both teams went to the Great Southern Wood Team Welcome Reception.
The press conference featured GoDaddy.com Brand Marketing Manager David Welsh, Mobile Mayor Samuel L. Jones, Mohajir, Thompson, and representatives from Kent State. After opening comments by Welsh, Mayor Jones presented Mohajir a key to the city. Mohajir then spoke briefly and was followed with some brief comments by Thompson.
"We want to say thank you, especially on behalf of Governor Mike Beebe, System President Dr. Charles Welch, and Chancellor Dr. Tim Hudson, and we can't tell you how excited we are to be back here," Mohajir said. "Thank you so much for everything you do and thank you for the key to the city Mayor Jones."
"It's an honor to represent Arkansas State University and to be here in the GoDaddy.com Bowl," Thompson said. "Our players, our fans, and the whole community of Arkansas State are very excited about being back in this bowl. It is a pleasure and we're looking forward to this week."
At the conclusion of the press conference both teams went to the Great Southern Wood Welcome Reception which provided a southern-style shrimp boil and entertainment to the players, coaches, administrators, media members, and special guests.
Winners in eight of its last nine games, including the last seven in a row, the Red Wolves claimed their second consecutive Sun Belt Conference title with a 45-0 victory Middle Tennessee in their regular-season finale.
The Red Wolves are receiving votes in both major polls and are listed at No. 37 in the latest BCS rankings. A-State is receiving 20 votes in the latest USA Today Coaches Top 25 poll for its most in school history since joining the NCAA FBS in 1992. Kent State will bring an 11-2 record and No. 25 ranking the AP Top 25 Poll into the GoDaddy.com Bowl. The Golden Flashes are also No. 25 in the BCS rankings.
Fans are strongly encouraged to purchase GoDaddy.com Bowl tickets only through the ASU Ticket Office to directly support the Red Wolves and to ensure they receive priority seating within the designated A-State area.
Bowl tickets are only $45 per ticket when purchased through the ASU Ticket Office. Fans can go to AStateRedWolves.com to order tickets, and the ASU Ticket Office, located at the Convocation Center's lower red entrance, is taking walk-up and telephone (870-972-ASU1 or 888-278-3267) orders.


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Calculate Your Fuel Savings
The Chevrolet lineup offers several models that deliver impressive fuel economy ratings. Upgrading to a more fuel-efficient vehicle can help you save money every time you stop at a gas station. To help you get a better idea just how much you can save, Karl Chevrolet has provided this fuel savings calculator. Fill out the form on this page with the information requested, and then hit the button to get the results.
Actual rating will vary with options, driving conditions, habits and vehicle condition.
Please speak with our trade advisor for more information.


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Today, we are participating in a blogswarm with AMERICABlog, AKAWilliam.com, Bilerico Project, Blabbeando, Change.org, DailyKos, David Badash, Firedoglake-The Seminal, Good As You, Joe Mirabella, LGBTPOV, Mike Signorile, OpenLeft and Rod 2.0. We are asking you to submit a public comment in support of revising the discriminatory and medically unwarranted FDA lifetime ban on blood donations from any man who has had sex with another man (MSM) since 1977.
Today, the HHS Advisory Committee on Blood Safety and Availability is kicking off a two-day meeting to reconsider the FDA ban on blood donations from men who have had sex with men (MSM). The current policy has been in place since 1985 when no HIV testing was available and little was known about HIV/AIDS. Since then, while many policies towards blood donations have changed, and HIV testing has significantly advanced to the point where a permanent ban no longer makes sense, the ban still remains in place. The ban is also discriminatory in that it unfairly targets gay and bisexual men because it does not distinguish between high-risk and low-risk MSM, banning potential MSM donors who are HIV-negative and consistently practice safe sex or are in long-term monogamous relationships, while others with a significantly higher risk of HIV infection are subject to less restrictive deferrals or none at all. The ban also contributes to a dangerously and chronically low blood supply in a country in which approximately just 5% of all eligible donors give.
The NYC and DC City Councils have recently passed resolutions by votes of 42-1 and 13-0, respectively, urging a revision of the ban. Today, we are asking that you join their voices in calling for a more sensible policy.
Dr. Jerry Holmberg is the Executive Secretary of the Advisory Committee, and is tasked with accepting formal public comments from both organizations and individuals. He has made his e-mail available for this purpose. Please take a minute to e-mail Dr. Holmberg via firstname.lastname@example.com and urge him and the committee to revise the ban on blood donations from MSM.
In writing the note, you can use the facts we have listed below, a form letter we've put together at the bottom of this list post that summarizes the rationale for ending the ban, a personal note- or all of the above! These public comment periods exist because good government means advocates should have a chance to weigh in. Now's our chance to demonstrate that members of the public support sound science, non-discrimination, and a healthier America.
Please take a minute to tell Dr. Holmberg and the Committee that you support these principles by sending an e-mail to email@example.com. Urge a revision of the policy that incorporates sound medical, scientific, and non-discriminatory guidelines.
The additional reasons you can cite are below.
- Newer tests have shortened the window period in which HIV is undetectable to between 9 and 11 days. A permanent, lifetime ban is outdated and no longer makes sense.
- The U.S. blood supply is frequently at critically low levels. Less than 5% of all eligible donors give, while donation recipients include mothers delivering babies, trauma victims, cancer patients, transplant patients and others. The respected Williams Institute estimates that lifting the ban would result in an estimated 130,150 additional donors who are likely to donate 219,000 additional pints of blood each year, while shortening deferral to one year would result in 53,269 additional men who are likely to donate 89,716 pints each year.
- The ban is a form of discrimination by unfairly targeting men who have sex with men, or effectively the gay and bisexual community. A permanent, blanket ban is instituted on any male who has had sex with another male even once since 1977 and without regard for partner's HIV status nor for frequency, safe sex practices, or duration since. Yet if one has sex with an opposite-sex partner who is knowingly HIV-positive, he or she can give again in a year. This is discrimination and it is wrong.
- Other countries like Sweden, Argentina, Australia and Japan have either revised or completely lifted the deferral period, while Italy, Spain and France screen donors based on risk rather than a blanket ban on a community.
- The American Red Cross, America's Blood Centers, American Association of Blood Banks, American Medical Association, and a coalition of nearly fifty other organizations all support a revision of the ban.
You can use these reasons in combination with your own personal ones, or the form letter below. Please submit a public comment via firstname.lastname@example.com, and urge that the ban be revised to improve the nation's health, meet sound scientific practices, and eliminate discrimination. Thanks for helping improve the nation's health and eliminating another form of discrimination.
Here is a letter summarizing the scientific and social reasons for revising the ban for your convenience. Feel free to copy and paste into an e-mail:
Jerry A. Holmberg, PhD
Executive Secretary
Advisory Committee on Blood Safety and Availability
Office of Public Health and Science
Department of Health and Human Services
1101 Wooton Parkway, Suite 250
Rockville, MD 20852
June 10, 2010
Dear Dr. Holmberg,
I am pleased that the Health and Human Services Advisory Committee on Blood Safety and Availability (ACBSA) is planning to review the Food and Drug Administration's (FDA) decades-long ban on blood donation by any man who has had sex with another man since 1977. I strongly urge the Food and Drug Administration (FDA) to review its policy prohibiting gay, bisexual and other men who have sex with men (MSM) from donating blood.
The FDA's current blood donor eligibility policies are largely inconsistent, imposing significantly less restrictive deferrals to heterosexual men and women who engage in high-risk sexual behavior, yet banning gay and bisexual men who are HIV-negative, consistently practice safe sex, or are in monogamous, long-term relationships. This policy reinforces inaccurate stereotypes about gay men and HIV, and results in a significant loss of healthy blood donors.
The advent of new HIV testing technologies, which can detect HIV directly and has a window period of only 9-11 days after infection, has provided scientific and technological reasons to reconsider the policy. In the face of chronic blood shortages in the nation's blood supply, the unnecessary exclusion of large numbers of HIV-negative blood donors may harm patients in need of blood transfusions.
I join a growing consensus of voices who have called for reform of the FDA's donor eligibility policy. Many public health experts, the American Red Cross, the American Association of Blood Banks, America's Blood Centers, and others have supported reforming the policy. Additionally, 18 U.S. Senators, as well as U.S. Representatives, have recently sent letters to the FDA calling for the long-standing policy's review and modification.
It is both timely and necessary that an exhaustive review of alternative policies is conducted. I encourage Health and Human Services (HHS) and the FDA to act quickly to address our mutual concern for expanding the blood donor pool and ensuring the safety and adequacy of our nation's blood supply.


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The Cadillac STS is an American challenge to the technology, quality and great driving attributes of the high-end imports. The STS features responsive engines and, like all great luxury cars, uses rear-wheel drive, with all-wheel drive available for wintry climates. Factor in its comfortable cabin and comprehensive range of features, and the STS delivers a lot of luxury, technology and performance.
The 3.6-liter V6 with direct-injection developing 302 horsepower is standard equipment, with a 320-hp 4.6-liter V8 optional. Both STS models come with a six-speed automatic transmission. Both are modern aluminum powerplants boasting double overhead camshafts, four valves per cylinder and variable valve timing.
Safety technologies include Cadillac's Lane Departure Warning and Side Blind Zone Alert systems, plus a sophisticated StabiliTrak electronic stability control system that uses steering and other inputs, and brake and throttle controls, to reduce the chance of a dangerous skid.
The roomy cabin is superb, with comfortable, supportive seats that are infinitely adjustable, ample storage space, and superior sound systems, including 15-speaker Surround Sound.
The STS is unmistakably a Cadillac, but it's also a four-door performance sedan for people who like to drive. The standard suspension is tuned for a smooth and comfortable ride, while the available active suspension instantly adjusts to any driving situation, whether cruising through a sea of potholes or accelerating around a sweeping turn. Rear-wheel drive provides the balance and control serious driving enthusiasts demand, while the available all-wheel drive very beneficial in bad weather.
Changes for 2010 are minor, with two new colors: Vanilla Latte and Tuscan Bronze ChromaFlair.
The Cadillac STS comes with a choice of V6 ($46,845) or V8 ($56,345) engine, each with a six-speed automatic transmission. All-wheel drive is available for the V6 ($1,900) and V8 ($1,550).
Standard STS features include leather upholstery, aluminum interior trim, dual-zone automatic climate control, Bose AM/FM/CD stereo, interior auto-dimming rearview mirror, OnStar telematics (with one year's service), StabiliTrak electronic stability control, automatic high-beam control (Intellibeam) for the headlights, rear park assist and the usual lineup of power assists, creature comforts, extra conveniences and driver aids.
Optional packages for the V6 model include the V6 Luxury Package ($3,540) with two-position memory for seats, mirrors, climate and radio controls; Rainsense wipers; six-disc in-dash CD changer; Sapele wood trim on the instrument panel, steering wheel, console and center stack; heated and ventilated front seats with four-way power lumbar; heated rear seats; heated steering wheel; tire-pressure monitor, universal home remote; and a cargo net. Other packages include the V6 Luxury Collection ($4,500), a V6 Luxury Level 2 Package ($3,950), a V6 Premium Luxury Collection ($2,740), a V6 Platinum Edition ($7,950), and a V6 Premium Package ($9,100). Options for the V8 include the V8 Premium Luxury Collection ($4,655), V8 Platinum Edition ($6,500), and V8 Performance Package ($12,440).
Stand-alone options, included in some of the packages above, include Performance Handling ($1,600), power moonroof ($1,200), Performance Brakes ($395), DVD rear entertainment ($1,985), 18-inch polished alloy wheels ($600), and enhanced StabiliTrak with active steering for the V8 ($995). A Bose 5.1 Studio Surround Sound system with six-disc CD changer and DVD-based navigation is available.
Safety features that come standard on all models include dual two-stage frontal airbags, front seat-mounted side airbags, front-and-rear side-curtain airbags, anti-lock brakes, StabiliTrak electronic stability control, tire-pressure monitoring, and OnStar; its operators will contact appropriate assistance if there is an airbag deployment (meaning the vehicle has been in a wreck), and the passengers don't respond to calls.
Lane Departure Warning uses a camera located between the inside rearview mirror and the windshield to detect lane markings on the road and alert the driver when the vehicle inadvertently strays from the intended lane. Side Blind Zone Alert uses radar sensors behind the rear fascia that signal an audible and visual alert if objects are detected where it might be difficult for the driver to see them. Enhanced StabiliTrak with active steering is available only on V8s with AWD.
The Cadillac STS has a distinctive, crisp profile with an almost box-like silhouette that somehow still looks aerodynamic. Gently curved A-pillars and C-pillars tend more toward art than science. Sharply contoured lower rocker panels tracking rearward from the front fascia's bottom edge pull the body down, adding a stylistic ground-effects look. It's all very consistent with Cadillac's art and science design motif.
Up front the STS has a boldly traditional eggcrate grille with Cadillac's trademark vertically stacked headlamps. Chromed air extractor vents mark the clean flanks, and more subtle chrome accents adorn the door handles and rocker flares.
The rear has vertical taillights bracketing a tall, squared-off trunk lid. Recessed into the trunk's rear surface is a trapezoidal inset, big enough for European-spec license plates, housing large backup lights at the left and right extremes. Dual polished aluminum exhaust tips exit below the rear bumper.
The Platinum Edition features 18-inch chrome-finish wheels, a unique grille finish, Olive Ash wood trim with Saddle-stain leather-wrapped interior, premium floor mats, Tuscany full-leather seats and additional features.
The Cadillac STS cabin is warmer in appearance than the exterior, with soft leather surfaces complemented by warm wood accents. Those wood accents cost extra, but we much prefer them over the standard brushed aluminum trim, which looks and feels cold and reflects sunlight to the point of annoyance. Our advice: Order the wood.
The seats in all models are refreshingly supportive, for a Cadillac, without being overly firm. All essential controls are within easy reach, although there could be more clearance between the lower door panels and seat bottoms to access the front seat adjusters. For this reason, we especially liked the seat memory feature, which often saved us from having to reach down for the adjusters. The interior is noticeably roomier than that of the marginally smaller CTS.
Instruments are easily-scanned, white-on-black round analog gauges, with a large nested tachometer and speedometer between the smaller fuel and engine temperature gauges. The speedometer changes between English and metric electronically, so there's only one set of numbers around its circumference.
Cruise control and running lights are managed via a stalk on the left side of the steering column, windshield wipers and washers with a stalk on the right. Buttons in the steering wheel spokes provide redundant controls for audio and driver information functions. The steering wheel hub looks substantial, and even a bit futuristic. The available head-up display projects speed and other key information onto the windshield, so that the driver does not need to look down at the gauges.
The available Bose 5.1 stereo incorporates Surround Sound with 15 speakers. An integrated six-disc CD/DVD changer plays DVD-A, CD, and MP3 formats. An eight-inch VGA-quality touch screen and advanced navigation, Bluetooth phone capability, and OnStar with advanced voice recognition are all part of the package. A word of caution, however: The top-level stereo system, although delivering superb Surround Sound, is multi-tasked with a navigation system that, in combination, demands study of the owner's manual to operate with any degree of alacrity and confidence.
OnStar features a fully integrated GPS navigation system called Turn-by-Turn Navigation. Turn-by-Turn allows drivers to talk to a live advisor, who can download complete step-by-step directions to the vehicle through the OnStar system. These audio directions then automatically play through the vehicle's stereo as needed (after the OnStar operator hangs up), triggered by the system's GPS capabilities. This enables drivers to be led to their destinations while keeping their hands on the wheel and eyes on the road.
Storage cubbies include map pockets in all four doors. The front center console is deep and wide and pre-wired for cellular and Bluetooth. The glove box, though, is barely sufficient to hold the navigation DVD case and owner's manual. Two cup holders are provided front and rear. The trunk is fully lined, with articulated, gas-pressurized struts.
Fit and finish are top grade, with notably tight trim tolerances. Careful attention was paid to reducing noise, vibration and harshness, with remarkable and commendable success. Specially laminated windshield and front door glass, wind tunnel-tuned outside mirrors and high-density/low-mass sound-deadening padding make this a quiet car even by Cadillac standards.
The Platinum Edition features hand-cut and hand-sewn leather on the instrument panel, door trim and center console areas. The seats are fully covered with a semi-aniline leather called Tuscany. Wood trim is an Olive Ash burl stained a saddle shade. Chrome accents highlight the instrument panel and doors. Even the floor mats are upgraded, and there are Platinum badges on the door sills. Only two interior colors are offered: Ebony or Cashmere with Cocoa accents.
On the road, the Cadillac STS delivers everything promised by its slick looks and advanced specifications.
The V6 delivers 302 horsepower at 6300 rpm and 272 pound-feet of torque at 5200 rpm. It delivers good fuel efficiency, while its direct injection technology enables a 25-percent reduction in cold-start hydrocarbon emissions. With direct injection, fuel is sprayed directly into the cylinder, rather than into the intake port. As the fuel vaporizes in the cylinder, the air and fuel mixture is cooled. This enables the use of a higher, 11.3:1 compression ratio for better thermodynamic efficiency. The 3.6-liter V6 also features an isolated fuel-injector system, which helps reduce engine noise.
The six-speed automatic that comes on all models features a generous 13.88:1 maximum overall first-gear ratio for rapid launching off the line (13.11:1 with AWD), while also providing two overdrive ratios that decrease engine rpm and reduce noise levels while cruising at highway speeds.
The V8 generates 320 horsepower at 6400 rpm, and 315 pound-feet of torque at 4400 rpm. Both the 3.6-liter V6 and 4.6-liter V8 use electronic throttle control, to match the engine's performance to a variety of driver demands, from sedate highway cruising to rambunctious back-road motoring.
We especially enjoy the STS V8 with the optional performance handling package. Nudge the shift lever over to the right, into the manu-matic gate, and the selected gear will hold all the way up to the engine's redline, and this car can be taken to extremes heretofore beyond the reach of sedans wearing the Cadillac wreath and crest. The suspension engineers have demonstrated they understand the difference between too stiff and responsively firm. Thankfully, all the sound filtering and deadening doesn't keep the V8's throaty exhaust note out of the cabin.
The all-wheel-drive system is a hard package to top, complemented by Magnetic Ride Control and the latest generation StabiliTrak, though this adds some weight. Body lean in even the tightest switchbacks is minimal and mild dips are well controlled. Biasing 60 percent of the power to the rear wheels gives the all-wheel-drive STS the sporty dynamics of rear-wheel drive while sending enough power to the front wheels to help in bad weather. It's a good setup.
The electronic steering is a delight, its only shortcoming a slight softness on-center. The STS tracks well into and through corners, especially with the 18-inch, low-profile tires.
Active steering, available exclusively on V8 models with AWD, is integrated into the StabiliTrak stability control electronics. In addition to controlling brakes and reducing engine power, StabiliTrak with active steering can turn the front wheels to reduce skidding when rear wheels lose traction. The system includes a new steering motor assembly combined with computer-driven electronic controls that measure wheel slippage at all four wheels independently during acceleration, braking and adverse road conditions.
Brakes on the STS are up to the car's potential, with a firm pedal and a feel that's reassuringly linear. All of the various performance packages include four-piston Brembo calipers, with quite large vented brake rotors both front and rear.
The Lane Departure Warning system engages above 35 mph. A green light indicates that the system is turned on and working. Should the driver cross a detected lane marking without signaling, the light flashes amber while an alarm beeps three times. The system is designed to alert the driver to take appropriate action to move the vehicle back into the correct lane. To avoid nuisance alerts, the system is designed to not provide an alert if the turn signal is on or if the driver makes a sharp maneuver. The driver can switch it off, in which case the light goes out entirely.
The Side Blind Zone Alert system uses radar to sweep an 11-foot zone on either side of the vehicle; in other words, about one lane over. The zone starts at each side mirror and reaches back about 16 feet. With the system engaged, an amber symbol lights up in the outside mirror whenever another vehicle enters this blind zone. Cadillac cautions that the system is not designed to detect vehicles outside the side blind zone that may be rapidly approaching, or pedestrians, bicyclists or animals. It's designed to ignore stationary objects, such as fire hydrants or parked cars. In addition, the system displays do not come on while the vehicle is approaching or passing other vehicles.
The V6 and V8 engines represent the latest GM thinking, with double overhead cams, four valves per cylinder and variable valve timing. Called VVT, this system continuously varies valve operation to generate the most power from the least amount of fuel with the lowest emissions possible. Torque is what most of us experience as power in everyday driving; torque is what gets a car moving in the first place, as when accelerating from an intersection. Recognizing that, Cadillac engineers designed the STS engines to generate lots of torque throughout the rev range for responsive performance at all engine speeds.
The Cadillac STS offers a smooth and powerful driving experience with warm and luxurious accommodations. The STS V8 model with the Performance Package offers a great driving balance. We appreciated the all-wheel-drive model for its all-weather capability while maintaining the enjoyable sporty handling. People who enjoy getting where they're going as much as, if not more than, being there, but who pine for luxury touches and good old American V8 power, need no longer compromise.
NewCarTestDrive.com correspondent Tom Lankard reported on the STS, with Greg Brown reporting on the STS-V, and John F. Katz on styling.


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The BAFTA award winning indie platformer Thomas Was Alone is now available on Android and iOS. The game garnered critical acclaim for its PC, Mac, and PS3 editions, and is now promising the same emotional journey to mobile gamers.
Unlike many recent indie platformers that focus on bringing back the 80s style challenging gameplay, Thomas Was Alone focuses on keeping things simple. A majority of the fifty levels in the game are simple enough for even the most casual gamers to enjoy. The protagonist of this game is Thomas – a self-aware AI created accidentally. Thomas is represented as a simple red rectangle, and all he can do is move and jump. Over the course of his journey he meets up with other AIs, who are also represented as quadrilaterals. By combining each character's unique ability you need to traverse each level and reach the portal that'll take you to the next one.
Mike Bithell – the creator of the game, introduces enough variations and novelties to keep you engaged till the end, but the gameplay is still fairly basic. What elevates this game to greatness is the atmosphere. Thomas' journey is expertly narrated by Danny Wallace, whose humorous and quirky comments establish an emotional connect that'll leave you thinking about the game long after you have finished it. David Housden's minimalistic background composition suitable complements the level design and the narration.
I played the Android version of the game and did notice one annoying issue with the port. The option for switching between the characters is on the left and right edges of the screen, which makes it very easy to accidentally hit the Home button. Switching between characters requires too much attention and precision and often distracts you from the game. Hopefully, the developers will tweak the control scheme to address this issue. Other than this the game worked flawlessly, without any performance issues.
The game is available during this weekend at a 33% discounted price of $3.99, which is a steal for a game of this calibre. To make the deal even sweeter, the Bossa Studios has included the Benjamin's Flight DLC pack with twenty additional levels in the mobile version of the game. Thomas Was Alone is a mesmerizing experience that I can't recommend enough.
[ Download Thomas Was Alone from iTunes App Store or Google Play Store ]


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3530 Technologies
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Tailor-made for Banks, CUs & FinCos, the CreditCore Solution Suite intuitively and seamlessly handles consumer, online, business and indirect loans all together or standalone. Cloud based, and easy to use with unparalleled support -- our goal is provide the highest quality loan origination solutions in the industry.


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|Dawson, Harry
|Urban, Joseph
Submitted to: Journal of Immunology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/15/2005
Publication Date: 1/1/2006
Citation: Morimoto, M., Morimoto, M., Zhao, A., Madden, K., Dawson, H., Finkleman, F., Mentink-Kane, M., Urban Jr., J.F., Wynn, T., and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology. 176(1):491-495.
Interpretive Summary: The spectrum of cytokine profiles forms the basis for host defense against infectious disease; however, cytokines can also affect non-immune function such as the physiology of the intestine that can affect the absorption of nutrients. We examined the expression of receptors for the cytokine IL-13 that is involved in protective responses to worm parasite infection and in the expression of allergic disease. The nature of host/parasite interactions, identification of the pathways and critical mediators that contribute to host resistance, the factors that modulate susceptibility to infection, and the impact of enteric parasites on intestinal function are a few of the areas of research that hold much promise for development of novel therapeutic interventions. We observed that mice that genetically lack a high affinity receptor for IL-13 that is thought to regulate the available IL-13 that interacts with intestinal tissue demonstrate a high level of inherent hyper contractility of the smooth muscle of the colon. IL-13 expression in the small intestine contributes to the reduction in the uptake of glucose and an concomitant increase in fluid in the intestinal lumen. Control of smooth muscle function in the colon may be a way to regulate the effect of IL-13 and decrease the loss of water from the body. This work will be of interest to nutritionists who study food allergy and scientists interested in the role of parasitic infection in host immunity and nutrient absorption.
Technical Abstract: IL-13 induces a STAT6-dependent hyper contractility of intestinal smooth muscle that is mediated by binding to the IL-13R'1 component of the type 2 IL-4 receptor that is linked to STAT6. IL-13 also binds to IL-13Ralpha2 that is not linked to STAT6 and functions to limit the effects of IL-13 in vivo. In this study we assessed the contribution of regional and cellular differences in the distribution of the IL-13 receptor components to the physiological regulation of smooth muscle function in WT mice and mice deficient in STAT6 or IL-13Ralpha2. Expression of IL-13 and IL-13Ralpha2 was higher in colon than in small intestine. Laser capture micro dissection of specific cell types revealed that expression of IL-13Ralpha2 was higher in smooth muscle layer when compared to levels in the epithelial cells of the mucosa. In contrast, there was a uniform distribution of IL-13alpha1 in smooth muscle, epithelia and myenteric neurons. The significant hyper contractility of smooth muscle in mice deficient in IL-13Ralpha2, but not in STAT6, shows the physiological importance of IL-13 binding to IL-13Ralpha2. The pronounced differences in the expression of IL-13Ralpha2 suggest that the gut has developed sophisticated mechanisms for controlling or targeting the physiological and pathophysiological activity of IL-13.


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GAITHERSBURG, Md., Oct. 9, 2012 /PRNewswire/ -- MedImmune, the global biologics arm of AstraZeneca, announced today it will present four abstracts at the Influenza Vaccines for the World (IVW) International Conference at the Palacio de Congresos de Valencia, Valencia, Spain, October 9-12, 2012. These abstracts advance the body of existing data and knowledge surrounding influenza vaccination, highlighting MedImmune's continued leadership in helping to improve patient health.
MedImmune abstracts to be presented at IVW regarding influenza include:
Additional information about the 2012 IVW conference can be found at http://www.meetingsmanagement.co.uk/index.php?option=com_content&view=article&id=6&Itemid=7
About MedImmune
MedImmune, the global biologics arm of AstraZeneca PLC, has approximately 3,500 employees worldwide and is headquartered in Gaithersburg, Maryland. For more information, visit MedImmune's website at www.medimmune.com.
SOURCE MedImmune


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16 August, 2012 | (01 hr)
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Do you tell individuals at your organization that they are designated as high-potential leaders? Whether to inform nominees of their high-potential status is a difficult question. Some organizations hold back, fearing egos will take over, people will stop trying to prove their worth, and start acting entitled. Others argue that transparency is critical to organization success. To tell or not tell is one of the first questions people ask when they're developing their high-potential strategy.
Join us for a discussion moderated by The Conference Board where you will:
- Explore benefits and risks of informing high-potential leaders of their status
- Hear the research behind the recommended approach
- Learn guidelines and best practices to communicate with your high-potential leaders
Audience: Executives responsible for succession management in their organizations with the majority coming from human resources, leadership development, talent and global talent management, training and development, and employee development
Dawn L. Baker
Dawn Baker manages Dow's High Potential leadership development programs as part of the Human Capital Planning & Development (HCPD) team. Dow is a diversified chemical company that combines the power of science and technology with the Human Element to constantly improve what is essential...Full Bio
Cori Hill
Claudia "Cori" Hill is the creator of Active Leader, the simulation-based leadership development approach that has grown to be the single most frequently delivered and globally accepted learning program at PDI Ninth House. Cori came to PDI Ninth House in 1998 from Northwest Airlines w...Full Bio
Rene Carew, Ed.D.
Dr. Rene Carew is Program Director for The Conference Board Executive Coaching Conference. For several years she was also the Program Director for the Succession Management Conference. Rene has been an Organization Development Consultant, working with profit and not-for-profit organizations...Full Bio


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ODU To Play Notre Dame In NCAA First Round In New Orleans
By ODU Athletics
March 14, 2010
NORFOLK, VA-- The ODU Monarchs (26-8) will open the NCAA Tournament against The Fighting Irish of Notre Dame (23-11) Thursday in New Orleands, LA.
ODU is an 11th seed and Notre Dame will be a sixth seed. Also in the bracket is number three seed Baylor and 14th seed Sam Houston.
ODU and Notre Dame have met only once before. The Irish beat ODU, 67-62 in the 1983-84 NIT.
ODU has played Baylor only once, defeating the Bears 87-79 in the 1974-74 ODU Kiwanis Old Dominion Classic. The Monarchs have never played Sam Houston.
ODU has already played a BIG EAST team this season, knocking off 11th ranked Georgetown 61-57.
Blaine Taylor Quotes" Quite different from 2007 when we were an atlarge team, hoping to get in. We didn't have to wait too long then. This time, We knew we were getting as an automatic and our name didn't come up until the end. I just wanted to head south.
We feel quite fortunate to experience what's coming up. New Orleans is an historic city, and we are playing a Notre Dame team that is very skilled, solid and extremely well coached. They have been tested all year long, and they have an outstanding big man.
I think our schedule has prepared us for this tournament and we are looking forward to the challenge. "