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Update at 4:30 p.m. EST. Details Of Capture
Osama bin Laden's son-in-law and a former al-Qaida spokesman, Sulaiman Abu Ghaith, is in U.S. custody and is being held in a Manhattan jail. He could appear in a federal court as soon as Friday, U.S. officials familiar with the case say.
His capture is considered important not just because he was so close to bin Laden but also because U.S. officials have decided to try him in a federal court, not Guantanamo Bay.
Abu Ghaith, 48, may be best known for his multiple appearances in al-Qaida propaganda videos. In one, shortly after 9-11, he is seen sitting next to his father-in-law, the founder of al-Qaida, as he took credit for the Sept. 11 attacks. Then Abu Ghaith took the microphone to praise the attacks as well.
"I commend our CIA and FBI, our allies in Jordan, and President Obama for their capture of al-Qaida spokesman Sulaiman Abu Ghaith," Peter King, a Republican congressman from New York, said in a statement, confirming the arrest. "I trust he received a vigorous interrogation and will face swift and certain justice."
Living In Iran
After the Sept. 11 attacks, Abu Ghaith went into hiding, although officials had a pretty good idea where he was. He was part of a contingent of top al-Qaida operatives who have been hiding in Iran for the past decade, according to U.S. and European counter-terrorism officials.
They say the list of people living there reads like a Who's Who of al-Qaida founding members, including Saif al-Adel, a man who was rumored to have been a top contender to lead the group after bin Laden was killed by U.S. commandos in Pakistan in 2011.
It has been an open secret that those al-Qaida operatives – and often their families — are living in Iran just over the border from Pakistan. Their ability to move around and leave Iran appears to depend on the whims of the government there.
Sources familiar with the case say that bin Laden's son-in-law left Iran last month to travel to Turkey. He entered the country under a false passport and Turkish authorities subsequently found him and arrested him in a luxury hotel in Ankara, the Turkish capital. They held him briefly but then decided that they couldn't detain him because hadn't committed a crime on Turkish soil.
Abu Ghaith is originally from Kuwait. He was stripped of his passport soon after 9-11, so he is essentially stateless. Nevertheless, the Turkish authorities decided to deport him back to Kuwait via Jordan.
It was during that transfer that U.S. officials picked him up, officials said. Some media outlets are reporting that the CIA was involved. Others say it was the Special Forces.
The U.S. government has not said how Abu Gaith came into its custody. But he was flown to New York after a big internal discussion within the U.S. government on the best venue in which to try him. And it appears the decision was to bring charges in a federal court.
Where To Put Him On Trial?
On the surface, Abu Ghaith would appear to be a perfect candidate for the military commissions tribunal at Guantanamo Bay. That is where the alleged 9-11 defendants – Khalid Sheikh Mohammed and four other men – are on trial.
The military commissions were created to try terrorism suspects who are foreign and have al-Qaida links; so bin Laden's son-in-law certainly appeared to qualify.
In fact, Congress has required that these sorts of defendants be taken to Guantanamo, or at least be put in military custody, as a matter of course. But the administration has been very adamant about not being hemmed in on these kinds of prosecution decisions.
There is a chance that Abu Ghaith will appear in court tomorrow, though observers are unlikely to get a look at him. It would likely be a closed court session in which is indictment is officially unsealed.
The FBI has been talking to him since he arrived in New York and it was unclear whether he was cooperating. If he is, then it is less likely that there will be in court appearance on Friday. The prosecution may want to see how much he is willing to cooperate before he is charged.
Update at 6:07 p.m. ET. Charges Of Conspiring To Kill Americans
Ghaith has been charged with conspiring to kill U.S. nationals, according to the indictment against him.
"No amount of distance or time will weaken our resolve to bring America's enemies to justice," said Attorney General Eric Holder. "There is no corner of the world where you can escape from justice because we will do everything in our power to hold you accountable to the fullest extent of the law."
Here's our original post:
A son-in-law of Osama bin Laden has been extradited to the United States and could appear in court as soon as Friday, say sources familiar with the case.
The man, Sulaiman Abu Ghaith, may be best known for his appearance in videos. He was sitting next to bin Laden when the al-Qaida leader took credit for the Sept. 11, 2001, terror attacks. He has been in videos advocating more violence against the U.S. And he has been wanted by U.S. law enforcement for some time.
Ghaith was arrested in Turkey in February, the sources say, after he entered that country from Iran under a false passport. Turkey then said it would deport him to Kuwait, via Jordan. He was intercepted by U.S. officials in Jordan last week and then brought to the U.S.
Sources say Ghaith is now in Manhattan.
Rep. Peter King, R-N.Y., tells The Associated Press that Ghaith's arrest is a sign that "definitely, one by one, we are getting the top echelons of al-Qaida. I give the (Obama) administration credit for this: it's steady and it's unrelenting and it's very successful."
Bin Laden was killed by U.S. Navy SEALs in May 2011 during a raid on the compound where he had been living in Abbottabad, Pakistan.
(Dina Temple-Raston is NPR's counterterrorism correspondent.)
Osama bin Laden's son-in-law has been captured in Jordan, flown around the world and is now being held in a Manhattan jail. He's expected to appear for arraignment tomorrow in federal court. He'll be charged with conspiracy to kill U.S. nationals.
NPR's Dina Temple-Raston joins us now from New York with the details. And, Dina, tell us what you know about bin Laden's son-in-law and his role in al-Qaida.
DINA TEMPLE-RASTON, BYLINE: Well, his name is Sulaiman Abu Ghaith, and he's 48 years old. He was a spokesman for al-Qaida, and he appeared in a lot of the terrorist organization's propaganda videos. He was in one video that came out just a day after the 9/11 attacks, in which bin Laden took credit for the attacks, and Abu Ghaith praised him on camera. He was sitting right next to his father-in-law in that video.
So he's someone U.S. intelligence officials have been tracking for a really long time. They unsealed his indictment and, basically, he's being charged with conspiracy to kill Americans.
CORNISH: And I gather after 9/11, he went into hiding.
TEMPLE-RASTON: He did. Officials had a pretty good idea where he was. He was part of a contingent of top al-Qaida operatives who've been hiding out in Iran for the past decade. And the list of people there reads like a who's who of remaining al-Qaida founding members. It had been an open secret that they were there, and this is mentioned in the indictment they unsealed this afternoon, that he arranged to smuggle himself into Iran from Afghanistan in 2002.
CORNISH: Now, what do you know about how he was captured?
TEMPLE-RASTON: Well, we understand from sources familiar with the case that bin Laden's son-in-law had left Iran last month to travel to Turkey, and he entered Turkey under a false passport. Authorities there found him in a luxury hotel in Ankara, and they arrested him and they held him briefly. And then they decided they couldn't hold him because he hadn't committed a crime on Turkish soil. So they decided to deport him back to Kuwait where he is originally from. And then Abu Ghaith was on his way to Kuwait via Jordan when U.S. officials picked him up.
CORNISH: And then they bring him to New York?
TEMPLE-RASTON: Apparently, there was a big internal discussion within the U.S. government on the best place to try him. And it appears they decided the best place was a federal court in the southern district of New York.
CORNISH: So a federal court in New York instead of, say, Guantanamo.
TEMPLE-RASTON: Well, on the surface, you'd think he'd be a perfect candidate for the military commissions. These courts are supposed to be for terrorists and suspects who are foreign and have al-Qaida links, so he appears to qualify. But, in fact, Congress has required that these sorts of people be taken to Guantanamo, not federal court. But from the charges that were unsealed today, those are kinds of charges that aren't internationally recognized as war crimes, but are very common in federal courts in the United States.
CORNISH: And so they are, in this case, looking to try him in federal court in New York.
TEMPLE-RASTON: Exactly. In the southern district of New York, which has done a lot of these terrorism trials, he's scheduled to appear at 10 a.m. tomorrow. The FBI's been talking to him since he arrived in New York, and it's unclear whether he's cooperating. If he is, it's less likely that there would be a court appearance tomorrow because this is when all the horse trading happens, when charges are tweaked in exchange for cooperation. So that's the next thing to look for, whether he's cooperating. You know, he was in Iran with a bunch of people that the U.S. is very eager to capture and talk to, so he could be very helpful in that way.
CORNISH: That's NPR's Dina Temple-Raston speaking to us in New York. Dina, thank you.
TEMPLE-RASTON: You're welcome. Transcript provided by NPR, Copyright NPR.


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In a small town where everyone knows everyone else, a person is murdered and everyone is a suspect.
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Church Mazes and Labyrinths
Church mazes have long been used for making spiritual walks or pilgrimages along the spiraling path toward a rosette or other religiously significant decoration.
Generally church labyrinths have stopping points along the way so walkers may pause and reflect, pray, contemplation or meditate before continuing.
Mazes are muticursal patterns, more complex than simple labyrinths, with several paths or branches and dead ends through which the solver must find a route to the destination.
Print on paper and walk these labyrinths with finger paints, color crayons or markers. Enlarge and recreate these patterns to create real labyrinths on sidewalks, driveways or on flat surfaces, beaches or in sand or snow.
Make a soft maze mosaic by selecting colorful foam sheets and cut into random shapes with scissors to mix together then view solutions to all maze puzzles.
Create a maze or labyrinth mosaic by cutting up pieces of colored felt or foam sheets and gluing the pieces onto a surface to make a pattern.
Resources and References
Links to Internet websites on various types of mazes and labyrinths around the world. Many labyrinths and mazes are open to the public and available for tours.
Visit these links to find activities, mumber games and other great learning references and resources for mazes and labyrinths.
Maze/Labyrinth Locators
Where in the world to find mazes and labyrinths open to the public.
Visit these links to find activities, mumber games and other great learning references and resources for mazes and labyrinths.
- World-Wide Labyrinth Locator
- South American Labyrinths
- Activities
- hospital labyrinths
- Garden mazes
- Garden Maze Quilts
- Masking Tape Labyrinth
- String Labyrinths
- Historic Church Labyrinths in England
- Photos of Church Labyrinths
History of Mazes and Labyrinths
Since the beginning of documented civilization, labyrinths and spiral patterns have been found everywhere ancient indigenous people have lived and traveled.
The most commonly known design is the seven circuit Cretan labyrinth designed during the Minoan civilization on Crete around 2500 B.C. The Cretan labyrinth is considered to be the classical design. The earliest found Crete labyrinth image is scratched into a clay tablet fragment of pottery from the palace of King Nestor at Pylos in southern Greece. The intense heat of a fire that had destroyed the palace preserved the clay tablet.
The Cretan labyrinth told the mythological story of Theseus and the Minotaur. The Cretan labyrinth was an elaborately built maze like structure designed to hold the Minotaur, a horrible half-man, half bull creature that threatened King Minos of Crete. King Minos ordered Daedalus to construct the labyrinth so the Minotaur could never escape. Apparently Daedalus built the labyrinth so well that he barely escaped after construction was completed.
Even though he was trapped in the Labyrinth, the Minotaur demanded periodic sacrifices of women and warriors alike, so Theseus, along with the aid of King Minos' daughter Ariadne, destroyed the Minotaur. Theseus went on to be considered a legendary hero in Greece.
History of Mazes and Labyrinths
Mazes and labyrinths have undergone quite an evolution since the first cave dweller scratched the first spiral labyrinth on the cave wall. To learn more about the labyrinth and maze visit the resources and definitions pages.
Modern mazes include these giant Corn Maze Crop Circle seen in these photos provided by NASA.


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News Summary: US productivity up in summer
MORE PRODUCTIVE, CHEAPER WORK FORCE: U.S. worker productivity grew at an annual rate of 2.9 percent, faster than the initial estimate of 1.9 percent. Labor costs fell at an annual rate of 1.9 percent, a bigger drop than the 0.1 percent dip initially estimated.
THE REVISION: Productivity was revised higher because economic growth was stronger in the third quarter than first estimated, while hours worked were unchanged. Productivity is the amount of output per hour of work.
TREND STILL WEAK: Productivity is up just 1.7 percent over the past year, below the long-run average of 2.2 percent. Productivity is expected to remain modest next year, as companies reach the limits on the amount of work they can squeeze out of their existing work forces.


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GOCE: Orbiting on the edge
Orbiting on the edge of space at just 268 km, GOCE would have a mere eight days before sinking dangerously low if its ion propulsion should fail. Some of the first responders who would have to react in such a contingency are the flight dynamics specialists on ESA's Operations Team.
To achieve the mission's crucial scientific objectives, ESA's GOCE (Gravity field and steady-state Ocean Circulation Explorer) must orbit as low as possible, in order to sense minute variations in the Earth's gravitational field (see links for background on mission objectives).
This presents unique challenges for the entire flight operations team at ESOC, the European Space Operations Centre, but particularly so for the flight dynamics specialists responsible for determining GOCE's orbit, calculating its position and orientation and - together with the Flight Control Team - reacting to any onboard contingency.
"We orbit on the edge of reentry; if anything goes wrong, we have very little time before we start dropping down - about eight days before we get dangerously low," says Marco Antonio Garcia Matatoros, lead Flight Dynamics Coordinator for GOCE.
GOCE: Revealing an intimate portrait of Earth
Addressing the challenges of global change, Europe is launching GOCE to map our planet's gravity field in unprecedented detail. As part of ESA's Living Planet Programme, GOCE is the first of a series of Earth science missions called Earth Explorers.
The GOCE gravity-field map is crucial for deriving accurate measurements of ocean circulation and sea-level change, both of which are affected by climate change. GOCE-derived data are also needed to understand more about processes occurring inside the Earth and for use in practical applications such as construction, planning and surveying as well as providing a reference sea-surface level.
Orbiting fast and low
The spacecraft - a technological marvel with autonomous electric propulsion - relies on its aerodynamic shape for stability and orientation control. At GOCE's super-low altitude, the atmosphere is sufficiently dense to exert relatively significant drag forces on the spacecraft. There are no moving parts, such as the reaction wheels or jet thrusters normally used on spacecraft to slew, rotate and point scientific instruments or radio antennas.
We orbit on the edge of reentry; if anything goes wrong, we have very little time before we start dropping down.
The cutting-edge electric engine generates up to 20 mN (milli-Newtons) of ion thrust, which is roughly equal to the weight (on Earth) of a few drops of water. But this is sufficient to enable GOCE to maintain its nominal altitude at about 270 km and slowly lift it to safe altitudes during eclipse seasons (when less sunlight means less power for the electric propulsion). The fuel tank holds 40 kg of Xenon propellant, sufficient for a 30-month mission.
GOCE is the first ESA satellite employing 'drag-free control' (in which the satellite is in pure free fall around the Earth) and the first-ever satellite to use electric propulsion to continually compensate for atmospheric drag. The DFACS (Drag-Free and Attitude Control Subsystem) performs autonomous determination and control of the spacecraft's attitude pointing, angular movements and linear and angular accelerations.
The DFACS uses, among other inputs, signals from the EGG (Electrostatic Gravity Gradiometer) - the primary on-board scientific instrument - to provide information on the drag experienced by GOCE. The propulsion is then varied automatically to maintain the required velocity and altitude. GOCE is one of the first missions to use data from an on-board scientific instrument in flight control (usually, scientific and flight control systems are separate).
"The DFACS is fully automatic, and GOCE's altitude varies continuously. A crucial step during LEOP will be calibrating on-board magnetometers in order to establish full control over the spacecraft," says Garcia Matatoros.
Intense activity during Launch and Early Orbit Phase
LEOP refers to the critical 'Launch and Early Orbit Phase', lasting some three days after launch on 16 March, when the entire Mission Control Team will work in shifts 'on console' in ESOC's Main Control Room 24 hours per day.
The cutting-edge electric engine generates up to 20 milli-Newtons of ion thrust, which is roughly equal to the weight (on Earth) of a few drops of water.
During LEOP, the Flight Dynamics team will provide continuous support from a specialised Flight Dynamics Room, located just a few metres away. During LEOP and the approximately 45-day commissioning period, the spacecraft will be commissioned and all on-board systems will be verified for proper operation.
Throughout the mission, to fix the spacecraft's position, the team will use the SSTI (Satellite-to-Satellite Tracking Instrument) - a state-of-the-art GPS (Global Positioning Satellite) receiver on board GOCE that has been specially adapted to operate in a low-Earth orbit environment.
It can simultaneously track 12 GPS satellites and provides both science data and real-time information on spacecraft position and velocity. "SSTI will give us a position fix accurate to within a few metres, and we will update our orbital forecasts every day for the coming seven days," says Garcia Matatoros.
After injection into orbit at an altitude of 285 km by its Russian Rockot booster, GOCE will follow an unusual orbital profile, gradually 'falling' over the next 45 days to its first operational altitude of around 278 km.
The Flight Dynamics team's daily work will be complicated by expected variations in atmospheric density - by up to a factor of two in a very short time - due to extreme solar conditions - and on longer scales because of the 11-year solar cycle. GOCE's nominal altitude will also vary from 268 km to 278 km depending on seasonal variations in how the Earth eclipses the Sun.


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56:53 minutes (26.04 MB)
This week our Conversation topic was parents and their role in the school. Lisa and Maria were joined by Lorna Costantini, co-host of the Parents as Partners webcast. The conversation was informative as well as thought provoking. There was a lively chat in our chat room that shouldn't be missed.


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Finding commercial real estate in Newark
Finding commercial real estate in Newark
Google Rating
Based on 261 reviews
Bluebell Relocation Services
Dixon Richard
16:02 07 Oct 20
Amazing relocation service Provider Company in the New Jersey. It was literally the best deal, I have ever received. Their crew members were always is willing to go above as what I had expected. Outstanding moving service and there was no damage of any piece of furniture. Highly recommendable business of bluebell relocation services.
Mat Bowlin
17:38 03 Oct 20
Anthony is one of the best movers I have ever consulted. I was anxious about my artifacts, but everything went well from packing to moving it to a nearby town. All thanks to his outstanding team, I am delighted to avail of the services.
Kathryn Mitchell
16:51 02 Oct 20
Bluebell Relocation Services provided me with the best storage solution. I am happy with the whole process, from booking a consultation appointment to shifting my extra furniture to their storage space. The entire shifting process went smoothly because of their incredibly good management. I strongly advise all to use their services.
Bradley Ella
16:50 02 Oct 20
We recently moved the furniture to our new house with the help of this company. The moving team was great, energetic, and highly skilled. I am amazed to hire them.
Pamella Benac
16:23 02 Oct 20
I highly recommend this company. They were on time, super organized, and the crew very hardworking. Marcos and Daniel did such flawless work. I am very happy.
Glenn K
15:08 01 Oct 20
Haute Trend
18:56 25 Sep 20
I'd like to preface this review by first saying that this is my 10th move and so I have YEARS of experience with many many different moving companies, but BLUEBELL RELOCATION SERVICES - particularly the team: John, Marcos, Daniel and Terrance exceeded my expectations and deserve all the stars possible.To begin, the team was schedule at very short notice to pick up a large cross country move- It is wonderful to know that there is q local company that was priced right that could also accommodate such a short notice and long distant move so quickly.Second, I couldn't be happier with the crew. All gentleman were extremely professional and well mannered; each introduced themselves by name, spoke kindly and NONE OF THEM USED ANY FOUL LANGUAGE.Why does this matter? because in previous experiences the crews I have had would come and not only curse up a storm but I would feel a level of discomfort that always made me feel as if I had to have someone accompany me. I was too afraid to be left alone....NOT WITH THIS CREW.John, Marcos, Terrance and Daniel were not only kind and well mannered, but they were respectful and true gentleman. Truly. As a female, I can say that I felt comfortable and safe and respected. Thank you gentleman for not being pigs but being good men.The men took extreme care of my property, making sure to handle even the most minuscule of things with genuine care making sure everything was properly packed and situated appropriately in the truck so that nothing would move or slide.They were each focused on their task but what I appreciated the most was how well they all worked with each other. There was no horsing around, no fuss and they each made sure to clean up. What I found very encouraging was that they each made sure to have each other's back, help one another out when needed. There was no "bossing around" and no harsh demands.The energy was really fluid and positive. I couldn't make this up if I tried.To sum up, If I could use 5 words to Describe this team I would say:Professional, Responsible, Respectful, Honest, and Thorough.I would ABSOLUTELY recommend Bluebell again and ESPECIALLY THIS CREW. I commend this team for making an otherwise extremely stressful event, go totally seamless. I hope the management team uses this particular crew as an example for their other crews so any other customers could have the same experience I had.I hope my experience across country can match the level of quality on all fronts that I received today.Thank you gentleman for everything you've done today for me and for helping add a glimmer of positivity to this new journey for me. It would be a pleasure if our paths crossed again.Thank you bluebell management for sending these men.
Lola Bradley
14:04 18 Sep 20
I request to everyone to must try their servicesif you are in search for the best movers in this city. I have used priorly a few moving companies also but bluebell relocation services are the best. Most professional, considerate and very diligent with the furniture wrapping procedure. I seriously couldn't be happier more.
Steve Kelly
14:03 18 Sep 20
They have a group of stellar team force who had just take merely 5 hours to move all of the 1 BR belongings. In spite of having the no elevators, they didn't make any complaints and did their work accordingly in a super flexible manner. All in all, it's a 5 star rating performance.
Lisa Perry
15:36 13 Sep 20
After impressing by reading the reviews of this company on various platforms, I felt an urge to talk to them about the auto shipping job. As what I had read, they were totally the same and matched perfectly to my expectations. Even though I asked a numerous questions related to the work, they didn't seem hesitated to answer any of the queries with amazing customer etiquettes.
Monique Peters
15:34 13 Sep 20
Great in execution of everything whether it was the movement of sofas or the heavy mattresses. Moving job always felt stressful for me and for my family members but these were expert in turning out this job as super easy for us. Thanks a lot.
Blanca Moreno
15:31 13 Sep 20
My friend recommended Bluebell Relocation Services for such work. They sent a team which looked over the trash. They quoted me the lowest amount in the entire Brooklyn, all my trash is gone without any trouble. Kudos team.
Raj Shah
12:55 07 Sep 20
Waad Nakad
15:14 21 Aug 20
WORST MOVING COMPANY OUT THERE!Would never use this company again. When movers came to pack up my stuff they charged me a crazy amount for packing materials which wasnt made clear to me from the start and prices for materials should have been outlined ($100 a TV box... for a BOX! along with tape etc..). They were super unorganized, any time i did talk to them the quote had changed and dates were off.After they picked up my stuff, when i reached out with any questions, I never heard back. The timing was WAY off from their estimate compared to when my stuff actually got delivered with zero communication in the meantime. They didn't give me a 24 hr window and arrived earlier than they said which for any planning to your day is not ok.My stuff arrived bent, boxes smashed etc..The only thing that wasn't awful about this experience was that the movers were nice and thats it.Overall an awful experience and i will never use this company again and nor should you if you are looking for movers.
Brian Muehe
02:50 06 Aug 20
No more PAYING people for reviews at Bluebell you are making a lot of unhappy customers out here in NJ(via all the other reviews that speak for THEMSELVES here on google and your 2* on mymovingratings) and eventually your own greed will be you own demise. You call the office non stop can never get a hold of the OWNER. Have to chase him down just to talk to him its the most unprofessional moving company extorting people for their furniture, charging extra for gas and mileage instead of travel time. Anyway to get MORE money. Check all receipts make sure you read EVERYTHING you sign because if you don't the owner will take advantage of you scam you and you will get the run around from the three in the front office as if it were a game I have first hand knowledge. This is coming from someone who ran A1 American Moving out of Bloomfield for 12 years growing up and understands moving inside OUT.USE ANOTHER COMPANY!YOU have been warned!After the 30th poor review you have to ask yourself is it everybody else or is it the COMPANY?
Edmund Del Torro
21:58 15 Jul 20
Cant get my quote then I logged on again and the site doesnt work for me.
Brian Gussiaas
00:18 06 Jul 20
Jeff dePesquale
09:06 26 Jun 20
I was feeling tense about how to shift my daughter's luggage to her hostel. These people from Bluebell Relocation Services outsourced that for us. Thank you guys for your superb and pocket-friendly services. It was really a great experience with you all.
Lee Nelson
09:06 26 Jun 20
Brilliant packaging and moving services are rendered by you guys. I highly recommend Bluebell Relocation Services to all.
Ashley Benton
09:14 24 Jun 20
Shifting is really a troublesome task for me. Bluebell Relocation Services really made it easy breezy. They used the advanced packaging material and technique to make sure that no harm comes to my expensive and fragile stuff. Thank you guys for taking all the headache on my behalf. Highly recommended to hire them.
Moe Alsumidaie
18:53 18 Jun 20
A++ service. These guys saved me from Flatrate moving. Excellent customer service and they don't rip off clients like the other moving company.
Emma Hall
12:43 09 Jun 20
Anthony was so helpful in throughout the moving process and it was the best decision I had made to deal with him. There were some large piece of furniture but they had handled at a great ease and so diligently. Everything went well and in a transparent manner. I must say no one will regret by hiring Bluebell relocation services.
Colin Anderson
13:48 02 Jun 20
The services of bluebell relocation were quite hassle-free even in the on-going of global pandemic Covid-19. Anthony was very much careful with our belongings and took care of each and everything. I would highly recommend their services for the next move.
Antonio Moore
13:47 02 Jun 20
Mohammed Wardeh
17:29 08 Apr 20
THEY ARE THIEVES, VANDALISTS AND A PRESCRIPTION FOR A DISASTER.I read the warnings of not to use them but I was deceived by the GOOGLE GUARANTEE emblem.If you have a furniture that you wish to see how it's destroyed, then give those guys a call. I have PICTURES as a proof of their professionalism.1 - Punctuality:When I first called them, I asked them about April 13th availability and I also asked about April 6th. Then I decided and made sure that I am clear that what I want was the 6th of April. However, their representative wrote the offer based on the 13th, and it was my fault that I trusted his professionalism and didn't read the fine print. Come the 6th and guess what? All of my stuff are packed and no one showed up. I called in and was hit by excuses followed by a series of lies that it was a miscommunication.As a result, they sent me 2 movers instead of 3 movers at the same rate!!!! When I told them it's $175 for 3 movers and not 2 movers, they said well the price for the 6th is different than the price of 13th of April. Therefore my remaining balance after paying the 10% down payment jumped from $650 to $1000!2 - Value and Professionalism:I had to disassemble the bedroom, the bunk beds and carry whatever I can with them.They broke my kids bunk beds.They put boxes upside down and the glass inside it is shattered.They left the furniture without assembling it and walked away why? Because their time is up. It was 07:30 pm and they need to take a break.Taking a break was a lie because they took a break and one of WENT TO SMOKE A JOINT ON THE JOB DURING THE BREAK!!!An expensive cherry wood office desk is destroyed.Bunk bed is left near the house door without even assembling anything. (You know, they need a break).They left the house like a battlefield has just happened.I regret my decision not listen to the bad reviews, DON'T DO MY MISTAKE.
Fuzzy Wuzzy
21:40 29 Mar 20
I had a horrible experience to say the least. Overpaid significantly more than what was quoted, dealth with a very challenging and unprofessional foreman and somehow my son's massive race car that was perfectly packaged went missing. Stay away from this company. You'll save yourself from a lifetime of stress.
Diane Crowley
17:33 10 Mar 20
There were a few workers at this company that I thought were helpful and professional however the majority were not. Know in advance that the largest truck they use - 53 ft.- will most likely not be able to access even the ENTRANCE driveway if you are moving to an apartment complex. Although there had never been an issue at my new home, with others, Bluebell would not even attempt to pull in which according to the drivers happens almost 95% of the time. So plan well in advance that it is likely you will be charged approximately $650 more for the 'shuttle' which was a $69.00 per day 20 footer, rented. Yes I read and signed so clearly I am responsible and stuck. Also be aware that the list that they provide after an inventory at your home is dubious at best. Example- Those 4 lamps listed could in fact use 7-8 boxes which increases your bill by footage. This of course depends on whom is packing. It's all arbitrary. My total up charges were $1250.00 . I was told by 2 different employees that one was minuscule and the other I should have expected.In the end 2 driver/ movers were helpful and one packer 'Chris' was great and fair. Only reason for 2 stars.
Greg Baird
23:26 28 Feb 20
This company is inexcusably AWFUL! They are scam artists who use rank amateurs to pack and handle your belongings and who incur extremely high breakage, delays, lost items, and constant up-charging once the trucks are being loaded. Check out YELP and Better Business Bureau!!
Martino Romeo
03:16 24 Feb 20
Absolutely awful. To start, the estimate was 60% lower than the actual final amount (by then though they have you over a barrel since everything is already on the truck!). What a frustrating process too! I had menial items HEAVILY wrapped, presumably for protection? A roll of scotch tape literally had 5 sheets of industrial paper wrap. One of my plastic rulers also wrapped heavily in industrial paper wraps. These menial items filled a moving box which, after crunching all the numbers, costed me $422.46 to move. Insanity! I sent pictures and videos to management of me unwrapping these items and they have continued to "review the matter". Over a month and half later there is still no resolution. Nearly $10,000.00 for this move. Also, they subcontract out to other movers (this was cross country). The destination movers also nickel/dimed me. Never again! Hoping to help someone else avoid this tragedy of an experience.
chocolate chinadoll
01:26 16 Jan 20
The day the was supposed to pick up my furniture I never received a call saying they would be late so after calling a number of times I finally get a call back to tell me because it's so late in the day will it be ok to do the next day I said sure just to make sure everything was done correctly, then they tell me I should pack as much as I can even though I paid a extra $1000 for them to pack for me, none the less I been in Florida for about 2 weeks now and they are still tryna find someone to drive the truck with my belongings down here mind you I planned for my stuff to get here 2 days before me ,so im paying for a hotel along with rent and these people are sending me invoices about my furniture they still haven't delivered. THE WORST MOVING COMPANY I HAVE EVER DEALT WITH


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World Bulletin / News Desk
Thousands of Shi'ite Muslims turned out for the funeral of a man killed during protests triggered by the arrest of a prominent Shi'ite Muslim cleric in Saudi Arabia's oil-producing Eastern province, witnesses said on Wednesday.
Mohamed al-Felfel was one of two men shot dead on Sunday in what an Interior Ministry spokesman described as a "criminal act" after protests broke out following the arrest of Shi'ite cleric Sheikh Nimr al-Nimr on sedition charges.
Activists say the two men were killed by police snipers stationed on rooftops. The Saudi Interior Ministry denied the report.
The cleric's arrest and killings have raised the temperature in one of the most volatile regions in Saudi Arabia, where the kingdom's Shi'ite Muslim minority is concentrated. The U.S. embassy in Riyadh has warned its citizens to exercise caution when travelling to the area.
The Eastern Province is home to a Shi'ite population that has long complained of discrimination and marginalisation by the Sunni ruling family. The Saudi government denies the Shi'ite allegations.
Saudi Arabia, the world's largest oil exporter and a key regional ally of the United States, has so far escaped the "Arab Spring" protests that forced leaders in Tunisia, Egypt, Yemen and Libya out of power.
Activists posted videos of what they said was Felfel's funeral late on Tuesday in Qatif, showing large crowds, many of them men in white robes, chanting "Down with Mohammed bin Fahd" in reference to the governor of the Eastern Province.
They also emailed pictures of men holding placards attacking the royal family. It was not possible to independently verify the authenticity of the recordings and photographs or to determine where or when they were taken.
The Rasid news website said Saudi security forces stayed away from the funeral procession, which passed through the main Abdulaziz Street in the centre of Qatif.
A Saudi Interior Ministry spokesman did not respond to calls for comment.
Activists said the funeral of Akbar al-Shakhouri, the second man killed on Sunday, was due to take place later on Wednesday after some relatives arrive from out of town.
Appeals for calm
Shi'ite community leaders have appealed for calm during the funerals, urging people to avoid being drawn into a situation that could lead to bloodshed.
"This tense and difficult period that Qatif is passing through necessitates that we all work together to safeguard our society from any security deterioration, God forbid, to protect lives and sanctities," read a statement signed by a group of local notables, including Sheikh Abdallah al-Khuneizi, a former Shi'ite religious court judge.
The statement also appealed to security forces to exercise restraint and patience to get past a "dangerous and critical period".
Saudi Arabia acknowledged that some protests had taken place after Sheikh Nimr was arrested, but the Interior Ministry said there were no clashes between protesters and police.
"In the aftermath of the arrest ... a limited number of people assembled in the town of Awamiya," an Interior Ministry statement said. "Gunshots were overheard in the town. However, there was no security confrontation whatsoever."
Nimr is seen as a leading cleric promoting the Shi'ite cause. He had been arrested and released before.
His brother said police ambushed him on his way home from a farm he owns. Activists posted pictures on the Internet of a grey-bearded man they identified as Nimr inside a vehicle. He was covered with what appeared to be a blood-stained white sheet.
Activists said Nimr had been taken to the capital Riyadh.
Shi'ites say it is hard for them to get government jobs or university places, their neighbourhoods are run down, and their places of worship are often closed down.
The government denies such accusations.
Qatif is located next door to Bahrain, an island kingdom that has been in turmoil over demands by its majority Shi'ites for political reforms by the Sunni ruling Al Khalifa family.
Both Bahrain and Saudi Arabia accuse non-Arab Shi'ite Iran of fomenting unrest among their Shi'ite populations.
Protests broke out in the Eastern Province region in March 2011 when unrest in neighbouring Bahrain was quashed with the assistance of Saudi and other Gulf troops.Last Mod: 11 Temmuz 2012, 14:58


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Will Smith is set to drop beats, old school, as he signs on to The Legend of Cain, an epic story set around the biblical brothers Cain and Able. Smith will be playing Cain, the original badboy, with a vampiric bite.
Draco Malfoy a.k.a. Tom Felton is going to branch out from his bratty bad boy ways with a role in the 20th Century Fox sequel Rise of the Apes.
Are you a fan of elaborate special edition packages for your video game fix? You may want to check out the Zombrex Edition of Deadrising 2! For a fee of $79.99, you'll get the game as well as a heap of other shwag such as pens, notepads and more.
This past weekend AMC released the full list of writers and directors that will be heading up the first six episodes of "The Walking Dead".
Salt Lake City workers received a surprise as they forced water through a damn as part of an oil spill cleanup effort. The increased pressure coming from the lake's damn forced a corpse to float to the surface.
1692 - Five Salem witches are hung for the crime of witchcraft, based primarily on the accusations of little girls who were bewitched. Eventually, the village executes a total of 20 witches.


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A collection of scholarly works about individual liberty and free markets. A project of Liberty Fund, Inc.
The Best of the OLL No. 29: Norman Barry, "Hayek's Theory of Spontaneous Order II: Legal Orders" (1982) (Indianapolis: Liberty Fund, 2013). https://oll.libertyfund.org/titles/2508,
|Available in the following formats:
|EBook PDF
|This text-based PDF or EBook was created from the HTML version of this book and is part of the Portable Library of Liberty.
|ePub standard file for your iPad or any e-reader compatible with that format
|This is an E-book formatted for Amazon Kindle devices.
This is part of "The Best of the Online Library of Liberty" which is a collection of some of the most important material in the OLL. A thematic list with links to HTML versions of the texts is available here. This is part of a bibliographical essay on Hayek's theory of spontaneous order where Barry discusses Hayek's seminal contributions to the idea of spontaneous orders in law.
This work is copyrighted by the Institute for Humane Studies, George Mason University, Fairfax, Virginia, and is put online with their permission.
This material is put online to further the educational goals of Liberty Fund, Inc. Unless otherwise stated in the Copyright Information section above, this material may be used freely for educational and academic purposes. It may not be used in any way for profit.


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Postcard from camp: Steelers
SI.com has dispatched writers to report on NFL training camps across the country. Here's what Albert Chen had to say about Steelers camp in Latrobe, Pa., which he visited on Aug. 7. Read all of our postcards here.
At postcard-perfect Latrobe, Pa., where these fans of Steeler Nation have squeezed into the stands at Chuck Noll Field, scattered across the hills of idyllic St. Vincent College and lined up along the perimeter of the practice fields on a sultry 90-degree afternoon to watch the Rashard Mendenhall- and Mike Wallace-less Steelers. This is football heaven. Quick impressions from one packed day in the home of Arnold Palmer: The young offensive line is growing up quickly ("There have been some growing pains, but I really like what I see," said offensive coordinator Todd Haley), and Ben Roethlisberger's rotator cuff tear is a non-issue ("He's looking real good," said Antonio Brown. "He's having a great camp -- it's the Big Ben of old.").
1. Todd Haley is chill. Really. "I feel like I've come home," the new offensive coordinator said to me as we baked underneath the midday sun outside the cafeteria. Before he was the coach of the Chiefs, before he was the offensive coordinator at Arizona, Haley was a Steelers ball boy in the '70s when his father, Dick, was the team's director of player personnel. "It's special, the connection I have to this organization," he said, "and it really makes you want to accomplish great things."
For that to happen, Haley and Roethlisberger will have to play nice -- when I suggested that everyone's waiting for the first blow-up between quarterback and coordinator, Haley laughed. "Look, I'm passionate about this game and proud of it, but it was always about what the situation dictated at the time," he said, pointing out that at his prior stops, Arizona and Kansas City, the teams were mired in losing situations.
It's too early to say precisely how the offense is going to evolve under Haley, though we know this: the Steelers are restoring the fullback to the offense. They'll run more no huddle. The preseason opener against the Eagles last week offered more clues: the emphasis, as expected, seemed to be on a short passing attack and ball control, which will be a contrast to Bruce Arians' spread. There's still much for Haley and Roethlisberger to work out, of course -- Haley wants Roethlisberger to dump the ball off to the back more, Roethlisberger likes to check to his secondary receivers -- but so far, so good. Stay tuned.
2. No Rashard Mendenhall for now ... but the running game will be better in 2012. While Mendenhall will be out until at least October, the Steelers clearly have faith in Isaac Redman, despite lingering questions about the third-year back's durability (he's only logged double-digit carries in four career games and is already undergoing an MRI for a groin injury). It should be noted that while Mendenhall averaged 3.9 yards a carry since 2010, Redman, who when healthy will lead a committee that includes Jonathan Dwyer and Baron Batch, is averaging 4.5 yards over that time and riding the momentum of his 121-yard game against the Broncos in the playoffs.
Redman is ready for this moment -- he talked about losing some weight over the offseason to add some versatility to his game ("I'm trying to be more than a red zone back," he said). The Steelers ranked 14th in the league in rushing last year, but Haley will have them running more behind the improved line. The young linemen, David DeCastro at right guard and Mike Adams at left tackle, will struggle at times, of course, but the Steelers like Willie Colon at left guard. Marcus Gilbert continues to get better and Maurkice Pouncey is already one of the best centers in the league. The Steelers running game looks poised to be one of the best in 2012.
3. They don't seem to miss Mike Wallace at the moment, but they'll be hurting, badly, if he doesn't sign. There seems to be increasing optimism in camp that Wallace will sign and report to Latrobe any day now, though Pittsburgh is preparing for the possibility of life without its big playmaker. The concern here isn't the No. 1 slot -- everyone knows that Antonio Brown has the talent to be an elite receiver in the league. But beyond that it gets ugly fast. Emmanuel Sanders is a good slot receiver, but not everyone's convinced he can be an effective No. 2. Is Jerricho Cotchery the answer? Derrick Williams, David Gilreath, or Marquis Maze? Plaxico Burress?
Keenan Lewis, cornerback. The best camp battle is for the cornerback slot opposite Ike Taylor, with Bryant McFadden and William Gay gone. The fourth-year Lewis has started one game in his career, but is already talking about making the Pro Bowl this season. (No Steeler corner has made the Pro Bowl since Rod Woodson in 1997.) Lewis has worked with the starters but has also been held back with a shoulder injury -- that may open the door for Cortez Allen, who is exceeding expectations in camp.
Chris Rainey, running back. A sign of things to come? The explosive rookie back played early and often in the team's first preseason game and scored on a 57-yard screen pass. Rainey also was slotted as the team's primary kick returner. The former Gator, who used to live with Pouncey during their days at Florida, is an intriguing X-factor in the new Steelers offense -- Roethlisberger is already raving about the former track star. Haley will use him as a Dexter McCluster-type -- though by season's end, the 5-foot-9, 180-pound back will be drawing comparisons to Darren Sproles.
The Steelers' season begins where last year's ended: in Denver, against Peyton Manning, in the first of five nationally televised games. That's the start of a tough opening stretch -- four of the team's first six games are on the road (two out west). We'll find out early just how much the offensive line has improved. The division will be decided over three weeks late in the season, when the Steelers face the Ravens on Nov. 18, and again two weeks later. Bet on the Steelers if they're in the driver's seat in December: they finish with a favorable final stretch, with three of four games at home, the final two at Heinz Field against the Bengals and Browns.


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Kid Cudi's been relatively quiet for some time now, though the latest news about him has nothing to do with his music career or burgeoning acting career. Apparently the rapper has been embroiled in a highly contested custody fight with the mother of his daughter. According to TMZ, Cudi has lost the battle and will allow the mother to retain full custody of the child they share together.
The site reports:
Cudi said he got a place in Chicago just to be close to his daughter and her mother — and provided his daughter with generous support — but his baby mom said that was BS, insisting Cudi was provided "sporadic and inconsistent amounts" of support … and was an absentee dad.
In court docs, she also claimed Cudi has violent tendencies and a "long history of consistent drug and alcohol abuse."
The two parties finally agreed to disagree on August 3rd — and Cudi let his baby mama take full custody.
In return, she agreed to let him have visitation. Cudi will also pay child support.
Joe Budden Talks New Music And Role On Love And Hip Hop (VIDEO)
Katt Williams Flips Out On Stage In Oakland [VIDEO]
Rihanna's Unapologetic Triumph [REVIEW]

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A Fresh Look at a Familiar Parable
Posted by Elkin Presbyterian Church on Tuesday, October 29, 2013, In : Sermons
The Invisible Man
Posted by Elkin Presbyterian Church on Monday, October 21, 2013, In : Sermons
The Faith of a Scoundrel
Posted by Elkin Presbyterian Church on Tuesday, October 15, 2013, In : Sermons
St. Francis and the Canticle of Creation
Posted by Elkin Presbyterian Church on Monday, October 7, 2013, In : Sermons
Our Pastor
|Rev. Stuart Taylor
|Elkin, Nc
|Stuart was called to serve as the Pastor/Head of Staff for Elkin Presbyterian Church in January of 2013. He was born and raised in Greenville, South Carolina where his parents were charter members of the John Knox Presbyterian Church. He has two daughters. Rachel is finishing up at Tucson High School and her interests include active involvement in several sports, sustainable agriculture, steel drums and boys. She reads about two to three books a week as does her older sister. Lilly is a sophomore at Lewis and Clark College in Portland, Oregon and is an aspiring artist, a free thinker, and a gifted writer like her mother. His daughters are the apples of his eye. Stuart enjoys a daily exercise in the gym, hiking in the Blue Ridge Mountains, camping, reading, movies, dinner conversation, and researching his family history.


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Meet Lily Ashwell, An Emerging Designer With A Vintage Pedigree
Lily Ashwell has an ethereal quality about her. It's the way she holds herself (delicately), the way she speaks (softly), and the way she designs (dreamily). The 25-year-old just debuted a feminine holiday collection, the first under her eponymous label, that proves her goods are more than meets the eye.
"I don't like seeing the waste of materials and the waste of hard work that goes into a lot of fashion collections these days," she explains. So she turned to deadstock fabric — which she printed over — and lace — used as trim — to make old things new again. "I like the idea of clothes being really special and knowing that not hundreds of people are going to have them, so there's a very limited number of everything." It was time her spent in England that got Lily interested in all things vintage; the self-proclaimed "strange hoarder of beautiful things" turns to the extensive vintage collection she's now amassed for inspiration.
The daughter of British painter David Ashwell and Shabby Chic designer Rachel Ashwell, Lily spent much of her California-based childhood visiting family across the pond. She's now back in LA, where her nascent company is based, after indulging her Anglophilia with four years at London's Central Saint Martins. "At school, they did teach us to sew and all of the other technical aspects of clothing design, but they seemed more fid on the storytelling aspect of creating a collection," she says of what attracted her to the prestigious design program.
And Lily is deliberate in the use of storytelling in her creative process: "I think in a very cinematic way, so I usually start with a landscape of the setting where I see the collection, and the holiday collection was in Wales. I was feeling coastal towns meeting pastures and farmland, so I start with an image like that. Then I make journals, where I create an illustrated story of who this girl is. I'll go as far as designing her house and creating an all-encompassing story around her."
With a backstory literally all sketched out, she then goes to her vintage room — yes, she has a vintage room — to pick pieces that could fit into the narrative. She keeps her collections small, eschewing filler and keeping designs as seasonless as possible.
Of course, Lily also takes advice from her mother (who she calls "my mentor and biggest inspiration"), and has even set up a pop-up store within New York's Rachel Ashwell Shabby Chic Couture boutique. While she's just in the beginning stages of her career, she's planning on sticking around for a while.
"I just want to keep making beautiful things that speak to people and that will last for years and years. I try really hard in my clothes to make them as soulful and human as possible," she says. "I guess that's the word for my aesthetic, human."
Click through for images from Lily Ashwell's holiday lookbook, and see the full collection at LilyAshwell.com.


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Are you planning to build a new business premises in Central or Eastern Europe? Then you've come to the right address at Remco Ruimtebouw. Our steel building system is suitable for use anywhere in the world.
Poland, Romania, the Ukraine..... These are only a few of the many countries where you can find business premises built by Remco Ruimtebouw. We have constructed over 400 buildings, of a total area of almost 2 million square metres, in Central and Eastern Europe. And our Poland-based sister company Ocmer is also active in Belarus.
We take care of everything
For our international projects, we take care of the engineering, production, transport and assembly. And during the assembly period, there is always at least one experienced Remco Ruimtebouw Supervisor on site.
Corporate Social Responsibility
We build international projects together with local workers. This is both a source of income for the local people involved, as well as giving them a lot of experience that they can use in their future careers.
Work safety
The safety of our own staff and the parties with whom we work together has first priority. That speaks for itself! Remco Ruimtebouw is VCA** certified and works in accordance with this certification, both in the Netherlands and when constructing international projects.
High quality
Our building system guarantees high quality and a short building time, and we always meet the agreements we make with you. This ensures that you take possession of a steel business premises with its own, unique look that fully matches your wishes.
High customer satisfaction
We pay a lot of attention to customer satisfaction as part of our business operations and we are proud that this pays off: many a client has returned to Remco Ruimtebouw to once again rely on our trusted approach for expansion or new build projects!
Sustainable and environmentally aware
Our business premises are constructed to sustainable and environmentally aware standards. The materials we use can be recycled or can be reused in their entirety. This ensures that the buildings built by Remco Ruimtebouw do not pose a burden for future generations.
View some of our reference projects in Central and Eastern Europe here!
Would you like to know what Remco Ruimtebouw can do for you? Then please call us on +31 (0) 88 004 93 00 or email email@example.com. You can also find further information about building abroad on the right!


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AEM 6.4 User Guide Hub
Discover tutorials and articles for getting started with AEM
A selection of videos highlighting 6.4 new features
Discover what's new in AEM 6.4
User Guides and Resources
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Support delegates can get assisted support via:
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This is a fun project, a septic tank someone drove over and collapsed the top.
At ContractorTalk.com we cater exlusivly to professional contractors who make their living as a contractor. Knowing that many homeowners and DIYers are looking for a community to call home, we've created www.DIYChatroom.com DIY Chatroom is full of helpful advices and perfect for DIY homeowners.


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Interesting facts about Jakarta
Fly to Jakarta and experience one of the largest cities in the world. The capital of Indonesia, Jakarta is a diverse mix of cultures, including Javanese, Malay, Chinese, Indian, and European. The city is constantly growing and evolving, with unique cultural and historic sites worth visiting. Book your flights with Cathay Pacific and enjoy in-flight entertainment and reclining seats so you arrive ready to explore.
Things to do in Jakarta
Head to the city's National Museum of Indonesia, housed in the iconic Elephant Building, to learn about the country's history. Visit the National Monument, dedicated to Indonesia's independence, which was constructed by President Sukarno. Admire local Indonesian art at the National Gallery of Indonesia and enjoy the local theatre scene at the Gedung Kesenian Jakarta (the Jakarta Arts Theatre).
Getting Around Jakarta
Get around like the locals do: take a Bajaj, a vehicle similar to an Indonesian tuk tuk, or an Ojek, a speedy motorbike. Spot the Ojek drivers easily as they usually wear fluorescent-coloured vests. Otherwise hire a taxi or make use of the expansive bus system. Choose Cathay Pacific when you fly to Jakarta – our regular service via Hong Kong will get you there in comfort.


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Hot Olives
- Cook Time
- Prep Time
- 8Servings
- 2 cups mixed olives
- 1 fresh or dried bay leaf
- 1 sprig rosemary
- 2 tablespoons fresh thyme, chopped
- 1/2 teaspoon fennel seeds
- 1/4 teaspoon crushed red pepper flakes
- 1 long strip orange zest
- Extra-virgin olive oil (EVOO), for drizzling
Preheat the oven to 350 degrees . Layer 2 sheets of foil, each 18 inches long. Place the olives in the center of the foil and toss with the bay leaf, rosemary, thyme, fennel seeds and red pepper flakes. Add the orange zest and drizzle with EVOO. Pinch the foil together and seal to form a pouch. Warm the olives in the oven for 15 minutes.


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(Here's a 'lost' CDP essay from last year.)
A few weeks back, my debit card snapped in half while I was swiping it at a gas station. I was annoyed but not wistful– It had a good run. I use my debit card for literally every purchase I make. I seldom carry cash, open tabs at bars and absolutely never carry credit cards with me. My wallet consists of only my debit card, driver's license and various coffee shop punch cards, and that's the way I've always liked it.
I'm aware that while it's responsible to keep credit cards out of your wallet to limit impulsive spending (or because they're maxed out beyond all comprehension), it's also important to have some reserve funds on hand in case your debit card snaps in half at a Kwik Trip. I guess I like to live on the edge. F the police and soforth.
That evening, I contacted my credit union and requested a new debit card. They told me that a replacement would arrive at my door in a few days, and since it was an identical replacement (same number and expiration date), a re-activation wouldn't be necessary. As soon as it showed up, I could just place it in my wallet and start feverishly buying cat food and 90's anime as per usual.
I had the operator verify this statement three times. It didn't seem right to me. I should have trusted my gut.
I was home when my replacement card showed up in the mail. Following orders, I humanely euthanized the busted card (paper shredders have such a cathartic sound) and simply placed the new one in my pocket. After all, the operator said it was good to go, and surely the last thing a Call Center employee would do is say whatever I wanted to hear so they could end the call as quickly as possible.
I thought I'd celebrate a job well done by getting a sub sandwich for lunch. The Subway was about five minutes from CDP Headquarters, and I have the culinary abilities of a newborn giraffe when I'm alone in the house. I walked in, got into the (surprisingly lengthy) line and placed my order.
So many people feel that those in the retail and food service industries owe them something. I feel the exact opposite. Considering the work and care most people put into your food (or at least should be putting into your food), I'm always baffled at why sub sandwiches aren't $20 apiece. I watch, marvel, thank profusely and tip (when I have cash) every time. It's a job I fortunately never had to do, and I appreciate anyone who could just as soon gob into the mayonnaise every time you turned away, but doesn't for one reason or another.
"That'll be $5.29, sir."
I handed over my shiny new debit card. It was about to be de-virginized.
"Sir…It's saying that your card is declined."
Oh no. Oh shit no.
Not only was I upset because I didn't trust my gut when I assumed this would totally happen, but I didn't have any other money with me, the long line behind me was growing impatient and my sandwich had already been made. I've never been in this sort of nightmare transaction before. I had no idea what I was supposed to do. Just walk out? Didn't I still have to pay for the manual labor that went into the sandwich? This was about to get extremely embarrassing.
"Um, wow…okay," I said. "I…guess I have to leave?"
Confused beyond words (as were the onlookers behind me), I turned around and goose-stepped out of Subway without my sandwich, which was slowly turning to room temperature behind the counter. As I got back to my car, my initial thought wasn't that I should just run home and grab the money with which to buy this sandwich (I wasn't even planning on eating it anymore; I just wanted to make things right). No, my initial thought was "I'm leaving and never coming back. No way can I ever face these people again after what just transpired."
I eventually wised up and decided to reactivate my debit card in the parking lot. When I did, I questioned the operator as to the misleading information I was offered earlier:
"Yeah, I was told that I didn't need to reactivate this."
"(laughing) Who told you that?"
"You guys did!"
About 15 minutes after the fiasco, I bit my lip, lowered my head and walked back in. I needed to pay for this sandwich. Standing in line was weird to say the least:
"Hello! What would you like, sir?"
"Um, nothing."
"Yeah, I need to…just…never mind. I'm good."
When I got to the register, the same kid was there (for better or for worse). I explained to him what had happened, and that I didn't even want the (now gross) sandwich, I just wanted to give them the money they deserved and immediately hook up with the Witness Protection Program. Or at the very least, start eating at the Jimmy John's further down the street. My relationship with this franchise was officially over.
"Okay, sounds good. I just need to grab a manager. He needs to do a weird refund processing thing on the register."
The line behind me was getting longer and more impatient. I started to sweat.
When the manager showed up (who was 16 years old at best), he had to futz with a computer underneath the register to reverse the mistake I had made earlier. He was ducked under the register, and at one point near the end, the cash drawer dinged open without him noticing. When he went to stand back up, he bashed the top of his head underneath the register, sending the drawer and loose change flying everywhere. A nickel landed in the teriyaki sauce. It was probably the loudest thing that has ever happened inside of that particular establishment. A woman gasped.
I was goddamn mortified. This was all my fault. Not only did I ruin my day, I literally ruined the day of every single person in that Subway. The cashier, the manager, the sandwich artist, the customers, everybody. Again, I left with nothing.
And it cost me $5.29.


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Mega Semadhi Wins 2013 Rip Curl Cup Padang Padang
Local boy Mega Semadhi finds redemption at Padang Padang
and claims his first Rip Curl Cup in pumping barrels.
Semadhi, a Pecatu (Bukit Peninsula) local, was absolutely ecstatic with his win in his 10th Rip Curl Cup appearance, as he was so close to tasting victory last year just to have it snatched away from him in the final seconds by California's Chris Ward.
"This win means so much to me, here at my home and in front of my family, and because of last year too", said Semadhi. "In those final minutes I was trying to be patient, thinking that if I could lose in the final minutes like last year, I could also be the one to win in the last minute too. When that last set came in I said not this one, not this one, I gotta pick the right one. And then it was like a fairly tale come true when I heard the score and that I won."
Semahdi is currently studying to be a Hindu priest, and perhaps part of his studies is about patience as today it certainly paid off for the young man. Just a couple of weeks ago he was runner up in another ASC competition at Balangan Beach, and was bested by fellow Balinese goofyfooter Raditya Rondi, who held the lead in the final today until the final minutes.
Putting on a very impressive performance today in his first trip to Bali and his first ever surf at Padang-Padang was runner-up, 16-year old Jacob Willcox from Margaret River in West Australia. Willcox looked very comfortable in the often intimidating lineup, winning his first round heat by taking down locals Garut Widiarta and Marlon Gerber, besting Rizal Tandjung and Dede Suryana in the quarterfinals, and then Laurie Towner and Sean Peggs in the semifinals to get his Finals berth.
"This is my first time in Bali and first time to surf Padang-Padang, so I'm super stoked to come in second and happy for Mega, because he really deserved the win," said Willcox.
When asked what he thought of the wave at Padang Padang, he replied, "It's a great wave, similar to some of our barreling waves back home, so I felt at home out there. It was great to be out there with the Bali boys, they were all ripping, and it was such a close final and they were all chatting with each other and stuff. This is definitely one of my best experiences ever at a contest!"
Rip Curl SEA CEO Jeff Anderson was all smiles after the trophy presentation, saying, "We had to get tough some heats during round one, but from there it just got better and better. Mega has been in every contest…every single contest we've had at Padang-Padang. I talked to him after he won his semifinal heat and told him 'Mega, this is your year, you're going to win it this year,' I just had the feeling he could do it. He did have a bit of a struggle in the final, but that last wave came and it was magic. The whole crowd was behind him, it was just perfect! I couldn't be happier!"
The Rip Curl Cup has a longstanding tradition of running in only the best waves with the best tuberiders in the world, which at a wave like Padang Padang requires a lot of patience. Today was day 42 of the 45-day waiting period, and though there were lots of nay-sayers at the start of today's event, by the end of the day Padang Padang proved on again that it could deliver the goods and retain its stature as Bali's most sought after barrel riding experience.
A quality field of 32 barrel-riding specialist invitees from Australia, New Zealand, Tahiti, USA, Hawaii, Brazil and Indonesia arrived at Padang Padang beach this morning at daybreak to vie for the honor and privilege of hoisting the coveted Rip Curl Cup and having their name inscribed on it with the previous event champions.
2013 Rip Curl Cup Championship Final Results
1. Mega Semadhi (IND) 16.45 points
2. Jacob Willcox (AUS) 14.90 points
3. Raditya Rondi (IND) 14.90 points
4. Alik Rudiarta (IND) 11.90 points


text: 0 Daily Thoughts - 9 September 2014 Quotes for Success | Famous Quotes | Quotes for Happiness | Life Quotes | More... Markamoment Beautiful and meaningful positive affirmations from Everyday Affirmations to inspire you every day. See new positive quotes everyday in our affirmation gallery! No comments: Post a comment Copper Creations Handmade Jewelery Share Clipart Creationz Download Free Cliparts Tree of Life Pendants Artisan Jewelry


text:
Kurt Nimmo
November 8, 2012
Several states challenged the unconstitutional meddling of the federal government on Tuesday.
Despite a SCOTUS ruling upholding Obamacare earlier this year, voters in Alabama, Missouri, Montana, and Wyoming passed measures nullifying the insurance mandate of the so-called Patient Protection and Affordable Care Act.
While establishment pundits dismiss the ballot initiatives as mere political theater, the popularity of the proposals reveal that states' rights and nullification are alive and well.
In addition to rejection of the Obamacare mandate, voters in two states overturned archaic marijuana laws. Washington state and Colorado passed ballot measures legalizing recreational use of marijuana.
The Justice Department and the Drug Enforcement Agency have not yet responded to the decriminalization of pot in the two states, but establishment politicians are lining up in opposition.
''Federal law still says marijuana is an illegal drug, so don't break out the Cheetos or Goldfish too quickly,'' said Colorado's Democrat governor, John Hickenlooper.
Oregon and Arkansas voters defeated a similar law. In Massachusetts, voters approved a measure to allow marijuana use for medical purposes. 17 states now permit the use of medical marijuana.
"For more than a year, Americans fretted over who will occupy the White House for the next four years, and the media and political class have fixated on that race. But these nullification votes at the state level tap into a deeper current," Tenth Amendment Center communications director Mike Maharrey said following the election on Tuesday.
"Americans don't want a king. And they don't want their lives run by politicians in Washington D.C. shoving one-size fits all mandates down their throats. People in Colorado, Alabama and Washington know what's best for them, and they just sent a message to D.C. 'We will not submit to your unconstitutional acts and power grabs any more.'"
Maharrey also said arguments that the states can't defy the federal government because federal acts reign supreme over state law under the Constitution's "supremacy clause" are fallacious.
"They completely ignore the key phrase 'in pursuance of.' Unconstitutional acts aren't legitimate laws. They are illegal power grabs," he said. "Sure, the Supreme Court gave us its opinion on the constitutionality of Obamacare and federal marijuana laws. But their opinion is based on about 100 years of unconstitutional precedent. My challenge to folks is to point me to the enumerated power that delegates Congress the authority to create a federal health care system, or to tell every American what kind of plant they can grow in their own back yard. They can't – because it doesn't exist."
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The New Lenox Emergency Services & Disaster Agency is comprised of volunteer officers. ESDA serves the Village of New Lenox and surrounding communities through Mutual Aid support. The organization is deployed for emergency and non-emergency situations.
This community-based organization trains all officers in many areas including CPR/First Aid, emergency response, security, traffic control, etc. New Lenox ESDA officers bring their dedication to the organization to serve the community in times of need. To learn more, use the navigational bar on the left.
Mike Potocki
ESDA Director
Bill Potocki
ESDA Deputy Director
New Lenox ESDA is currently looking for new officers. Download the application and submit it to us or contact us for more information!


text:
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Book sources
This page contains links to websites where you can borrow, buy or find information about a book with a given ISBN. If you have been sent to this page by clicking an ISBN link, all the links will automatically point to the book with this number (ISBN 9780618680009). You can type another ISBN in the search box to change the links.
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Online text
- ISBN 9780618680009 at Google Books
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text:
It turns out that last year"s wine grape harvest wasn"t just spectacular, it was record-breaking.
According to the United States Department of Agriculture"s preliminary numbers, the 2012 grape crush in California totaled 4,383,100 tons, a record amount that marks a 13-percent increase over 2011"s crush.
"We thought it would be a good amount, it was a really wonderful harvest," said Glenn McGourty, the Winegrowing and Plant Science adviser for the University of California"s Cooperative Extension in Mendocino and Lake counties. "Not all varietals had really big crops, but it was a record crush statewide."
"It was an incredible year, and definitely up from the year before," said Chuck Morse, agricultural commissioner for Mendocino County, adding that two important numbers were up significantly for Mendocino County: the prices per ton and the volume of grapes.
For red wine grapes, the prices per ton were up 14 percent from 2011, while for white wine grapes the prices went up 19 percent, Morse said.
The volume increases were even higher. For reds, the increase was 20 percent, and for whites, it was 27 percent.
"The producers knew that the quality was good, and the tonnage was up," Morse said, so he knew 2012 had been a good year, but "when I actually looked deep into the numbers, I said, Holy cow, it was a good year!""
However, Morse said the increases were so dramatic in part because 2011 was such a bad year.
"It was very challenging," he said. "So many weather factors played against us."
By contrast, in 2012, growers said they had a good amount of rain, little frost, and a long season that let them leave their grapes on the vines as long as they wanted.
The weather forecasts for this year, though, don"t look as perfect.
"It looks a little trickier this year," McGourty said, adding that 2013 may be cooler and get less rain.
But even if the good weather repeated, he said "the chances of having two great crops in a row are remote. The vines get tired, the carbohydrates get depleted, so it takes a while for them to recover."
Zac Robinson, president of Mendocino Winegrowers, Inc. and family owner of Husch Vineyards, said the numbers for 2012"s crush in Mendocino County were "huge" and represented a dramatic increase.
"I think this is the first year the county"s crop pushed $100 million," Robinson said, pointing out that the crush report estimates its value, the total tons multiplied by the average price, "set a record at $101 million."
After reading the USDA"s crop report and completing an "initial analysis," Robinson said Mendocino produced 70,858 tons of fruit, an amount that is very close to the 2006 record and 23-percent higher than last year"s tonnage.
The top four varietals by tonnage were chardonnay, pinot noir, zinfandel and cabernet, and the average price paid to Mendocino grape growers "hit $1,425 per ton, an increase of 15 percent (from 2011), and the highest return to growers in over a decade," Robinson reports, adding that "Mendocino showed stronger price growth than both Napa and Sonoma counties."
But after crunching those impressive numbers, Robinson said he doesn"t picture everyone sitting around celebrating the large haul of great-quality, high-priced grapes for long. More grapes means more wine, which means more wine to sell.
"Call it a hangover," he said, explaining that if a winery brings in 23-percent more grapes than normal and fills up its tanks, it needs to sell that much more wine, or it will be cutting back on its purchases the next year.
"If they"ve got a warehouse full of bottled wine still, they"re not going to crush more," he said. "A surplus of fruit and wine is challenging on the wineries" side, and this (large crush) is going to put a lot of them in a little bit of a squeeze."
The good quality of 2012"s crop will certainly help, even with the higher pricetag, he said.
"The quality of the wine is fantastic," he said. "That"s really good news."
Justine Frederiksen can be reached at email@example.com, on Twitter @JustFrederiksen or at 468-3521.
By the numbers
Mendocino County"s record-breaking 2012 grape crush:
Total tonnage was 70,858 tons, up 23 percent
Top four varietals by tonnage were: chardonnay, pinot noir, zinfandel and cabernet. (Pinot noir was No. 4 last year)
Average price per ton was $1,425, up 15 percent
Total tons multiplied by average price: $101 million, a record
The county represents 1.6 percent of the total crop in California, and the average statewide price per ton of grapes was $734.
These numbers were provided by Mendocino WineGrowers, Inc., and based on information provided by the preliminary grape crush report released by the USDA. Read the full report at www.nass.usda.gov/ca


text:
Cignal 45-Pathway Reporter Array
For discovery of signaling pathway response to gene modification or chemical treatment
The Cignal 45-Pathway Reporter Array measures the activity of 45 signaling pathways. By screening pathway activities simultaneously, relevant pathways are quickly identified for further analysis. Cignal Finder Reporter Arrays pinpoint the pathways perturbed by a specific gene or drug. The plate format facilitates shorter transfection protocols and high-throughput analysis.
Buy Products
The Cignal 45-Pathway Reporter Array is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
Product Details
Each array includes 45 Cignal Reporter Assays and 2 controls in a 96-well plate format. Each reporter and control assay is dried down in each well of the plate.
All reporter assays are based on dual-luciferase technology. Each reporter consists of a mixture of a pathway-focused transcription factor-responsive firefly luciferase construct and a constitutively expressing Renilla luciferase construct.
Dual-luciferase results are calculated for each transfectant. The change in the activity of each signaling pathway is determined by comparing the normalized luciferase activities of the reporter in treated versus untreated transfectants.
The identically treated negative control serves as a specificity control. The positive control serves as a control for transfection efficiency, by monitoring GFP expression, as well as a positive control for both the firefly and Renilla luciferase assays.
The procedure comprises 3 simple steps (see figure "Cignal 45-Pathway Reporter Array procedure"):
The Cignal 45-Pathway Reporter Array is highly suited for research into phenotypes associated with RNAi or overexpression experiments, biological responses to small molecules or compounds, and mechanisms of action of proteins, peptides, and ligands.
Product Resources
fragment fix placeholder


text:
Well, they're not really vermin in my eyes, but to some they are! Meet Fate (DCR Too Much Heaven) and Serenity (DCR Melody Fair) from Deer Creek Rattery. It's been quite a while since I've had rats since my beloved Rosie passed away, but I finally was up for it and brought these two lovelies home.
This is Serenity
And here's Fate.


text:
In the middle of last week, Intel launched the new chipset for the Socket LGA1155 platforms. Dubbed the Intel Z68 chipset, it brings some new features to the table, as well as merges a few from the Intel H67 and the Intel P67. In our first article on the Intel Z68 chipset Joe took an in-depth look at Intel's Smart Response Technology. In short, Intel's Smart Response Technology… Well, I'll let Joe, the resident SSD expert at Legit Reviews, explain that for me:
Using the latest version of Rapid Storage Technology drivers (10.5) and adjusting some easy settings in the Intel Control Center you essentially create a RAID configuration which treats the SSD as a cache for the most frequently used data. Access then comes via the faster SSD rather than the slower HDD, increasing performance markedly. Right now, some are thinking, wait, this isn't new…we've seen a version of this before! The voices in your head are correct. A while back we had a look at the Seagate Momentus XT Hybrid drive which essentially employs the same concept, albeit all bundled on a single drive.
Along with giving us an in-depth look at Intel's Smart Response Technology, we also got a peek at the ASUS P8Z68-V Pro motherboard! This particular board is going to be the primary focus of our article today. At the launch of the Intel Z68 chipset, ASUS launched a pair of boards based on the Z68 chipset. The first is the ASUS P8Z68-V Pro that we are looking at today which has an expected retail price of $209.00. The second of the pair is simply the P8Z68-V which will cost a bit less at only $189.00.
Likely the biggest change, aside from the Intel Smart Response technology, is the addition of integrated graphics to what is basically the Intel P67 chipset. Just adding in the integrated graphics isn't what makes this a drastic change. What makes the addition of the integrated graphics such a grand change is the technologies associated with the Intel integrated graphics. The new Sandy Bridge processors have the graphics integrated directly onto the processor.
With the addition of the Intel integrated graphics we can now access the features that are tied to it. Features like Intel Quick Sync Video, Intel InTru 3D Technology and Intel Insider are now available on the top tier boards like the ASUS P8Z68-V Pro. Now, what makes this different than the Intel H67 Chipset? Well, you can access this while you run the latest discrete graphics card from AMD or NVIDIA! This not so small feat is accomplished by Lucid Virtu software.
|Intel Socket 1155 The 2nd Generation Core i7/Core i5/Core i3 Processors
Supports Intel 32 nm CPU
Supports Intel Turbo Boost Technology 2.0
|Intel Z68
|4 x DIMM, Max. 32GB, DDR3 2200(O.C.)/2133(O.C.)/1866(O.C.)/1600/1333/1066 Hz Non-ECC, Un-buffered Memory
Dual Channel Memory Architecture
Supports Intel Extreme Memory Profile (XMP)
|Integrated Graphics Processor
Multi-VGA output support : HDMI/DVI/RGB ports
– Supports HDMI with max. resolution 1920 x 1200 @ 60 Hz
– Supports DVI with max. resolution 1920 x 1200 @ 60 Hz
– Supports RGB with max. resolution 2048 x 1536 @ 75 Hz
Maximum shared memory of 1748 MB
|Multi-GPU Support
|Supports NVIDIA Quad-GPU SLI Technology
Supports AMD Quad-GPU CrossFireX Technology
|Expansion Slots
|2 x PCIe 2.0 x16 (x16 or dual x8)
1 x PCIe 2.0 x16 (x4 mode, black)
2 x PCIe x1
2 x PCI
|Intel Z68 chipset :
2 x SATA 6Gb/s port(s), gray
4 x SATA 3Gb/s port(s), blue
Support Raid 0, 1, 5, 10
Support Intel Smart Response Technology
Marvell PCIe SATA 6Gb/s controller :
2 x SATA 6Gb/s port(s), navy blue
JMicron JMB362 controller :
1 x eSATA 3G port(s), red
|Intel 82579, 1 x Gigabit LAN Controller
|Bluetooth V3.0+EDR
ASUS BT GO! Utility
|Realtek ALC 892 8-Channel High Definition Audio CODEC
– Supports : Jack-detection, Multi-streaming, Front Panel Jack-retasking
Audio Feature :
– Absolute Pitch 192kHz/ 24-bit True BD Lossless Sound
– Blu-ray audio layer Content Protection
– DTS Surround Sensation UltraPC
– Optical S/PDIF out port(s) at back panel
|VIA 6308P controller
2 x IEEE 1394a port(s)
(2 at mid-board)
|USB Ports
|ASMedia USB 3.0 controller :
4 x USB 3.0 port(s) (2 at back panel, blue, 2 at mid-board)
Intel Z68 chipset :
12 x USB 2.0 port(s) (6 at back panel, black+red, 6 at mid-board)
|Overclocking Features
|Overclocking Protection :
– ASUS C.P.R.(CPU Parameter Recall)
|Special Features
|ASUS Dual Intelligent Processors 2 with DIGI+ VRM:
ASUS Digital Power Design
– Industry leading Digital 16 Phase Power Design
(12-phase for CPU, 4-phase for iGPU)
– ASUS DIGI+ VRM Utility
– EPU, EPU switch
– Auto Tuning, TurboV, GPU Boost, TPU switch
ASUS BT GO! (Bluetooth)
– Folder Sync, BT Transfer, Shot & Send, BT to Net, Music Player, Personal Manager
ASUS BT Turbo Remote
– Exclusive Smartphone Interface supporting iPhone, Android, Windows Mobile and Symbian systems
ASUS Exclusive Features
– ASUS UEFI BIOS EZ Mode featuring friendly graphics user interface
– MemOK!
– AI Suite II
– AI Charger+
– Anti Surge
– Disk Unlocker
ASUS Quiet Thermal Solution
– ASUS Fanless Design: Heat-sink solution
– ASUS Fan Xpert
– ASUS Q-Shield
– ASUS Q-Connector
– ASUS O.C. Tuner
– ASUS CrashFree BIOS 3
– ASUS EZ Flash 2
ASUS Q-Design
– ASUS Q-LED (CPU, DRAM, VGA, Boot Device LED)
– ASUS Q-Slot
|User's manual
ASUS Q-Shield
2 x Serial ATA 3.0Gb/s cable(s)
2 x Serial ATA 6.0Gb/s cable(s)
1 x SLI bridge(s)
1 x Q-connector(s) (2 in 1)
1 x ASUS USB 3.0 Bracket(s)
|64 Mb Flash ROM, EFI AMI BIOS, PnP, DMI2.0, WfM2.0, SM BIOS 2.5, ACPI 2.0a, Multi-language BIOS,
ASUS EZ Flash 2, ASUS CrashFree BIOS 3, F12 PrintScreen Function
The ASUS P8Z68-V Pro motherboard is totally packed with features that gamers, enthusiast, and everyone in-between have come to love and expect on top tier boards. These are features such as BT GO!, which is an onboard Bluetooth module that allows you to sync folders, transfer data, and several other functions that are all available from an easy to use interface!
There are a number of features that we will be looking at as we go through our tour of the ASUS P8Z68-V Pro motherboard. That being said, before we delve into the ASUS P8Z68-V Pro too much further, let's take a look at the new Intel Z68 Chipset!
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text:
I'm sitting in a farang restaurant in Chiang Mai, Thailand. I'm there for the fast wifi and cold beer, eating a cheeseburger. An American man sitting next to me decides to chime in: "I see you've come halfway across the world to eat American food."
Now, this is a tourist place — their Thai food sucks. It's toned down for Westerners. If you want real Thai food, you go to a place with plastic tables and chairs and sit in the heat. He's eating what appears to be the worst plate of pad thai ever made. They don't even have chili in this joint. If you ask for chili, they bring you a bottle of tabasco.
"How long have you been in Thailand?" I ask.
"The wife and I have been here for six days now. We've got a couple more before flying back."
"Oh. That's nice." I just let the comment hang there — I'm not going to give him the satisfaction of explaining my story.
And, of course, after a minute he takes the bait. "How long have you been traveling?"
"Four years. I've eaten my body weight in Thai food. And sometimes I just want a friggin' burger."
That pretty much ends the conversation.


text:
Introduction to Next Generation Sequencing (NGS)
In Week 3 we introduced you to the traditional techniques used for genetic testing: PCR and Sanger sequencing. These techniques allow the analysis of around 500 nucleotides of DNA a time. For many genetic disorders, including diabetes, there are many genes that, when mutated, can cause the disease. For example, neonatal diabetes can be caused by mutations in over 20 genes. Sequencing all of them, a piece at the time, for every patient would be simply impossible. What to do then?
Now a new way to analyse genes is available: next-generation sequencing. This uses a new approach that allows sequencing of many genes at the same time. This is known as massively parallel sequencing. The main applications of this technique in diagnostics are:
- Custom-designed panel of genes (i.e. all the genes that cause monogenic diabetes)
- Sequencing of all the coding regions (the exome) in the human DNA: Whole Exome Sequencing
- Sequencing of the entire human genome: Whole Genome Sequencing
You will hear a bit more about the technical details of next generation sequencing in the next sections. But first let's consider how these techniques can help in finding a genetic diagnosis in patients with monogenic diabetes.
A gene panel for monogenic diabetes
There are currently 22 genes in which variants are known to cause neonatal diabetes and 16 with mutations causing MODY. We have designed a custom next-generation sequencing panel that includes all these genes and we are now routinely testing patients with a suspected diagnosis of monogenic diabetes using this technique. You can find more information about this test on our Diabetes Genes website.
The possibility of testing all the disease-causing genes has a huge impact on the patients' clinical management. Let's take neonatal diabetes as an example. Each of the 22 genes defines a different subtype of neonatal diabetes. Each subtype has different treatment options, is associated with the development of various additional features and has a different prognosis. Back when we undertook genetic testing by analysing one gene at the time, we needed to decide which gene we thought was most likely to be the cause of the disease. The decision was guided by the clinical features of the patient at the time of referral. If we didn't identify a mutation in the gene we had chosen, than we were stuck until the patient developed additional complications that were consistent with one of the neonatal diabetes subtypes. At this point the genetic testing was just confirming a diagnosis made on the basis of the clinical features.
Now, we don't need to try to guess the gene anymore, we can use next generation sequencing to test all the neonatal diabetes genes as soon as the patient is referred for genetic testing. This means that for an increasing number of patients the genetic diagnosis comes before the development of the additional complications. This way the genetic result informs clinicians on optimal treatment, on disease progression and raises awareness on the future development of additional features. In other words, the genetic result is now making the diagnosis rather than just confirming it.
From The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study, De Franco et al, Lancet. 2015 Sep 5;386(9997):957-63. Reproduced under a Creative Commons (CC by 4.0) licence.
If you would like to know more about the targeted test for all MODY genes we suggest you look at this material:
Improved genetic testing for monogenic diabetes using targeted next-generation sequencing, Ellard S et al 2013, Diabetologia
The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study, De Franco E et al 2015, Lancet. This Lancet publication describes how genomic testing changes the management of neonatal diabetes.
© University of Exeter