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Charles Nichols & David Nichols – DMT in the Mammalian Brain: A Critical Appraisal
Charles Nichols & David Nichols – DMT in the Mammalian Brain: A Critical Appraisal
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DMT in the Mammalian Brain: A Critical Appraisal
Charles D. Nichols & David E. Nichols. (Editors: Martin Fortier & Daniel A. Friedman)
Commentary on: Jon G. Dean et al., "
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
", 2019. [Link]
Recently, a publication from Dean et al. reported that N,N-dimethyl tryptamine (DMT) is synthesized in the rat brain cortex, present at levels similar to other monoamine neurotransmitters, and significantly increases in concentration at death. They further promoted the theory that DMT may serve as the causative agent for "near death experiences", which have been compared to peak psychedelic experiences. The publication certainly is interesting and suggests additional directions to explore scientifically but does not meet the bar for either claim that DMT is at functional levels in the cortex comparable to serotonin or is the "near death" neurotransmitter.
#N,N-dimethyl tryptamine (DMT) and the natural product admixture ayahuasca being used in shamanic rituals that contains DMT, is currently a very fashionable topic. Thousands of people worldwide have used DMT or ayahuasca in recent years under shamanic guidance or in a therapeutic setting where it appears to show benefit for antidepressant-like effects and helped with healing psychological trauma. DMT has been a trendy topic both in the scientific literature and the popular press, where several pieces have been published ascribing cure-all properties to the molecule, including proposals that it is the neurotransmitter responsible for mystical experiences in "near death experiences" where the individual has clinically died and been resuscitated.
The recent publication by Dean et al. (2019) is the next iteration in attempts by the some of the coauthors of this publication to prove that endogenously produced DMT has important physiological functions, and in particular could be responsible for the mental effects of a near death experience. In this publication, they report that DMT is found in rat brain visual cortex, with slightly elevated levels of DMT in brains of rats that were asphyxiated. Previously, some of these authors had proposed that DMT is produced in significant amounts by the pineal gland (Barker, Borjigin et al. 2013). One of us has reviewed that hypothesis and has pointed out that the pineal gland is not capable of producing physiologically relevant amounts of DMT (Nichols 201
. The present report by Dean et al. showing that DMT could be detected in rat brain in similar amounts, regardless of whether or not the animal had a functioning pineal gland, is consistent with our earlier argument.
In a previous publication by some of these coauthors (and prior to their studies focusing on DMT), Li et al. (2015) emphasized that asphyxia generates a "brainstorm" of neurochemicals. To wit, "An immediate and sustained surge of a large set of core neurotransmitters within the cortex occurs in response to asphyxia. In both frontal and occipital cortices, a dramatic and significant surge of neurotransmitter secretion was detected for as long as 20 min of asphyxia for all neurotransmitters tested." They found that cortical levels of serotonin (5-HT) surged more than 20-fold, norepinephrine more than 30-fold, and dopamine more than 12-fold. Additionally, levels of glutamate and other neurotransmitters including acetylcholine, adenosine, aspartate, taurine, histamine, and glycine all surged within minutes after asphyxiation. Thus, it is curious that Dean et al. (2019) focuses only on DMT as an important player in brain death within this context.
Activation of brain serotonergic 5-HT2A receptors is the mechanism whereby hallucinogenic drugs such as DMT induce visual hallucinations and mystical experiences in humans (Nichols 2016). One of the metabolic pathways for the endogenous ligand of this receptor, serotonin, is N-methylation, catalyzed by the enzyme Indoleamine N-methyltransferase (INMT), for which serotonin was its first identified substrate. Previous work by Schmid and Bohn (2010) showed that high concentrations of serotonin can induce the mouse head twitch response, an animal proxy for hallucinogenic activity, via activation of 5-HT2A receptors. Thus, the surge of serotonin alone following asphyxiation could be responsible for activation of 5-HT2A receptors and production of (the behavioral metric used in laboratory animal studies of) psychoactive effects. In addition, if INMT is responsible for production of DMT, and INMT also N-methylates serotonin (Axelrod 1962), there should be a peak in the HPLC trace for N-methylserotonin, but that is not evident in the presented HPLC traces (and these two molecules do not co-elute in HPLC analysis). Further, N-methylserotonin also activates 5-HT2A receptors to produce behavioral effects (Schmid and Bohn 2010) and this metabolite would be expected also to contribute to potential CNS effects mediated by the 5-HT2A receptor following asphyxiation. It should be mentioned that INMT is not specific for N-methylation of tryptamine, but also N-methylates a variety of other arylethylamines including, tyramine, normetanephrine, metanephrine, 3-methoxytyramine, dopamine, and octopamine (Axelrod 1962), as well as histamine (Herman, Bowsher et al. 1985). Importantly, therefore, INMT cannot be seen strictly as a proxy for DMT production.
As for the other neurotransmitters found to be dramatically induced in the cortex by asphyxia in the author's earlier work (Li, Mabrouk et al. 2015), norepinephrine has a central effect on arousal and alertness and also activates adrenergic receptors that are co-expressed on apical dendrites of cortical pyramidal cells, the same anatomic location where 5-HT2A receptors are expressed. Dopamine plays important roles in arousal, attention, cognition, and affective emotion. Increased brain glutamate concentrations can lead to out of body and hallucinogenic experiences (Gouzoulis-Mayfrank, Heekeren et al. 2005, Browne and Lucki 2013), and is a mechanism involved in the out of body experience induced by the anesthetic ketamine. With such a flood of neurochemicals, including those that can significantly impact CNS function and induce out of body experiences, it is not clear why the authors attach such importance to the relatively small increase in the amount of DMT in the brain following asphyxiation. Apparently, it is the recurring meme that because exogenous DMT is hallucinogenic, and because it can be produced in the brain, therefore it must be important there, and have some physiological (hallucinogenic?) role.
Another explanation for out of body experiences, e.g. at near death, that the authors again fail to consider could be the production of dynorphin (DYN) and other endogenous opioid peptides. DYN and its cognate kappa-opioid receptor (KOR) play an important role in regulating stress responsiveness, motivation, and emotion (Bruchas, Land et al. 2010, Knoll and Carlezon 2010, Van't Veer and Carlezon 2013, Donahue, Landino et al. 2015). DYN 1-13 is an extremely potent kappa receptor agonist, with 0.44 nM affinity at the kappa receptor in rhesus monkey brain (Emmerson, Liu et al. 1994). Readers will appreciate that salvinorin A, the hallucinogenic component of Salvia divinorum, is a selective and extremely potent agonist at the KOR that can produce hallucinogenic and out of body experiences (Roth, Baner et al. 2002). Other endogenous opioid peptides are produced during stress and would activate other classes of opioid receptors. The authors made no attempt in their work to measure production of endorphins.
A most critical aspect lacking in the discussion was a practical understanding of receptor pharmacology. 5-HT has a 10-fold higher affinity for the 5-HT2A receptor than DMT (PDSP Ki Database). Even if we accept that DMT is present at half the levels of 5-HT in cortex under normal physiological conditions, the combination of higher 5-HT levels and higher affinity of 5-HT for the target receptor indicate that DMT will not be engaging the receptor to any appreciable degree at baseline conditions. During asphyxiation, as the authors' previous work shows, and as they interpret data here, levels of serotonin increase over 20-fold compared to only a 6-fold increase for DMT (Dean et al. Fig 4A), further widening this gap. At these comparative levels, with the 10-fold higher affinity of serotonin, 5-HT2A receptors would be saturated with serotonin and engagement of receptors by DMT in the presence of that much serotonin (and/or N-methylserotonin) would essentially be zero.
There are additional issues with experimental design and interpretation of the data presented. For example, why was microdialysis performed in the visual cortex rather than the frontal cortex, where behaviors are mediated? Why was there no validation of RNAScope results with antibodies? mRNA levels do not necessarily correlate with expressed protein levels, and to state conclusively that the enzymes INMT and AADC are co-expressed in the same cells and synthesize DMT requires validation of the presence of the enzyme proteins themselves. The statement that "DMT would be the only monoamine whose biosynthesis takes place within the cerebral cortex where it may directly influence cognitive functions of the brain" is patently false. It has been known for years that monoamine neurotransmitters, including serotonin and N-methyltryptamines, are synthesized locally within the cerebral cortex where they can influence behaviors.
Perhaps most curious, in pinealectomized animals, the peak supposedly representing 5-HT is significantly blunted in comparison (Figure 4A & B). Why is that? The pineal gland does not regulate 5-HT levels in the brain and there is no expectation that the absence of this gland would alter cortical 5-HT levels after cardiac arrest. Further, two other un-identified peaks in the HPLC trace show the most significant increases after cardiac arrest (Figure 4B). What are these peaks? The authors do not address these discrepancies, but rather only compare serotonin to DMT in pinealectomized animals.
To be very clear, we are not arguing that DMT is not produced in the cortex of the rat. Rather, even with the production of amounts of DMT indicated by the authors' data, the higher levels of serotonin, and potentially N-methylserotonin, are much more likely to induce a behavioral response through the 5-HT2A receptor. The "brainstorm" of additional neurochemicals may also be relevant to altered consciousness, and in addition, suggests the potential role of dynorphin or other endorphins, which were not measured, cannot be discounted. As Dean et al. wisely conclude, "It is unknown whether the concentrations of DMT reported in our study at cardiac arrest can elicit the effects of an exogenous psychedelic dose of DMT…" And, "the conscious states reported by NDE survivors may involve contributions from several of the other neurotransmitters found to surge at cardiac arrest in our prior rodent study." Exactly our point here!
Science aside, a real problem with this report is that it is being taken up by the popular culture media and widely spread to a lay audience as now established dogma. Without a critical reading of the publication, advocates for the importance of endogenous DMT in the brain will and are saying, "see, we told you so." Unfortunately, it only serves to propagate a pseudoscience meme. If we take the "politics" of DMT out of the equation, and simply examine the data presented, the publication by Dean et al. certainly is interesting and suggests additional directions to explore scientifically, but does not meet the bar for either claim that DMT is at functional levels in the cortex comparable to serotonin or is the "near death" neurotransmitter.
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A most critical aspect lacking in the discussion was a practical understanding of receptor pharmacology. 5-HT has a 10-fold higher affinity for the 5-HT2A receptor than DMT (PDSP Ki Database). Even if we accept that DMT is present at half the levels of 5-HT in cortex under normal physiological conditions, the combination of higher 5-HT levels and higher affinity of 5-HT for the target receptor indicate that DMT will not be engaging the receptor to any appreciable degree at baseline conditions.
this is an important point. Many people don't seem to comprehend that A) We are genetically hardwired to favor serotonin production, B) Serotonin production inactivates DMT production, and vice versa via feedback inhibition, and C) although 5HT signals to a relatively smaller extent in the raphe nuclei, >90% signals in the gut, because that is where most tryptophan metabolism occurs.
the latter is less relevant to what Nichols et.al are referring to, but rather illustrates how less likely the production of DMT in the brain actually is. A 2016 study showed possible sequestration/storage of DMT in neural vesicles, which of course, is a much different scenario than "DMT is produced in the brain".
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1 Understanding the Market Before You Search Properties for Sale in Islington-City Centre West
1.1 Factors to Consider When Searching Property for Sale Near Islington-City Centre West
1.2 Transportation Near Islington-City Centre West Properties Search
1.3 Lifestyle Near Islington-City Centre West Property Search
2 Understanding The Price of Properties for Sale in Islington-City Centre West
2.1 The Cost of Living Near Islington-City Centre West Property for Sale
2.2 The Price of Properties Search in Islington-City Centre West By Neighborhood
3 Search Islington-City Centre West Properties for Sale Near You
3.1 Islington-City Centre West Property for Sale with Nearby Amenities
4 Brokerage Services For Properties for Sale in Islington-City Centre West
5 Available Properties for Sale in Islington-City Centre West
6 Properties for Sale in Islington-City Centre West Neighbourhoods
7 Recent News Concerning Properties for Sale in Islington-City Centre West
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The cost of living in the metropolis is high because Islington-City Centre West is full of high-end businesses and business opportunities with very decent wages. There are, however, cost-effective housing options in the city as well. The government of Islington-City Centre West raised the minimum wage from $11.6 per hour to $14 per hour to better equip locals for the high cost of living. There is even talk of adjusting the earnings further upwards.
individuals with career-oriented lives will find the city of Islington-City Centre West to be tailored to their interests because the economy of the city is full of economic and career opportunities for the professionals, tradespeople, and all other manner of business people.
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When searching for Properties for Sale, make certain they are along or near to major transit lines. Such a place mitigates the need to own a vehicle as public transport is well-structured in Islington-City Centre West. Even the Islington-City Centre West Transit Commission (TTC) acknowledged that almost all the investors who get one of the Properties for Sale in Islington-City Centre West have no need of their vehicles. They get around using the public transport system in place.
Islington-City Centre West has a subway-running from north to south- dedicated to the transport of bulky items. Other subway system assures the residents' transport needs are well catered for.
The TTC ensured that the Properties for Sale in the estates of Islington-City Centre West are well serviced by the transport lines. The system will be an efficient option even during busy peak hours. During the rush hours, the subway intervals are reduced to two minutes down from the five-minute intervals of the other times of the day.
The subway lines are accessible for transport from 6 AM to 2 AM daily except Friday- when the subways come alive at 8 AM.
The locals of Islington-City Centre West pay $150/month for the transport services- a far cry from the cost of gasoline, repairs, maintenances, as well as other expenses that face vehicle owners.
the Property Search in Islington-City Centre West are, therefore, superb saving opportunities. The TTC will help you save much more if you are a student or veteran. The two demographics enjoy significant discounts.
Commuters will have cards and mobile applications to ride in bus and subways of Islington-City Centre West very soon. A brand new TTC will take place in 2019, and it will be a really innovative system. individuals will pay their fares making use of apps and cards.
There will be also an upgrade for the parking system. If you don't have a private car of your own, you can have a parking place in Islington-City Centre West via the city and the private owners simply because they will be selling it.If you don't have a private car of your own, you can get a parking spot in Islington-City Centre West via the city and the private owners. You will have to take a parking permit from the city of Islington-City Centre West if you have to frequently park a car in any neighborhood area down the road. Travelers and tourists won't have to do this.
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You'll find that the costs of Property Search in Islington-City Centre West vary from one neighborhood to the other. Each neighborhood has a different security system, academic institutions, and amenities.
You can research online to know more about different Properties for Sale pricing of various neighborhoods. Not just Islington-City Centre West, but every Metropolitan on earth has various rates for Properties Search. You need to know that Islington-City Centre West is the second most expensive town in the whole of Canada. Islington-City Centre West Property for Sale are the most expensive in whole North America as well.
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At the same time, you'll pay a lot less (often half as much) for Properties for Sale in cheaper communities then you will in downtown Islington-City Centre West. Again, looking Property Search by region will shine light on the quality and value you can expect in each community.
The average home price in Islington-City Centre West for 2017(the last year on record) was just about $934,000as shown by the result of the latest Properties for Sale. At the same time, the same types of homes – three bedroom, two bath – in the Downtown core would set house buyers back $1.6 million on average.
The East End of Islington-City Centre West will prove to be the least expensive neighborhood in the city. Though, this does not simply mean in any way that housesare cheap here. There is an steady increase in costs of houses for sale in the past ten years. A few of the housesin Islington-City Centre West costs around $1.2 million. Some of the most expensive houses can be found in the East End side of Islington-City Centre West although is believed to be fairly cheaper when compared to the Downtown Islington-City Centre West.
Some individuals are not very enthusiastic to move towards the East End. individuals who have a high taste of luxury and more expensive housesare amongst them. When searching for the Properties for Sale in Islington-City Centre West, do not forget that the city's gentrification is towards the east. This basically means that the East End of Islington-City Centre West has lots of investment potentials. Securing any Property for Sale in East End would prove beneficial in the future.
East End is really having numerous investors because they make money with Properties for Sale in this part of the town. They expect the value of their houses to rise in the next decade. The expensive zones are getting more expensive at the same time. Their pricing is all beyond what most of the buyers can pay.
While the Properties Search price is expensive enough as it is, renting a home throughout Islington-City Centre West is not cheap, either. This is one of the reasons why East End is actually a preference for investors.
It is certainly a wiser move to Properties for Sale in Islington-City Centre West rather than rent a house or property. And as the rent and mortgage costs mean almost a similar amount of money, it doesn't make sense paying for something that will never be yours in the future. Do not forget that living expenses, along with Properties for Sale in Islington-City Centre West, also get costly with the passing of time. Across Canada, the price you will pay for phone plans, television and internet package, daily food expenses, groceries, and transit plan are among the highest.
When it comes to the ideal neighborhood for a professional career-driven life, then the Western end is the ideal place to look for Properties for Sale. This side of Islington-City Centre West is home to young professionals who are seeking to establish their careers.
There is a university found in the southeastern part of the neighborhood. That area is, therefore, full of students and university faculty that make the area pretty vibrant. There's a fast rise of businesses in the area and that has led to the increase and opening of a lot of business opportunities.
Prices in the neighborhood can be really low although when it comes to the cost of living, the real estate listings prices is still a little bit on the high side and with only a little one can support the younger generation staying in the community.
in as much as MLS Properties Search in Islington-City Centre West have started to go up. It cannot be said to be on the same increase rate with other places and this is because of the fact that public transport commuting is deemed to be longer and it is far from downtown.
It is definitely a great place to stay in, particularly if you love watching celebrities. This is because it hosts an international Film Festival every September of every year. Although, it is believed that residing here would be costly for you due to the price of Properties for Sale is up to the roof. in fact you would be shocked to know that the cost is higher than $ 1.5 million, and this keeps increasing from time to time. Not to get disappointed, you'll still find town housesand a single-family house at inexpensive rates.
To stay in the heart of Islington-City Centre West means living an urban life with a naturally busy atmosphere. Even though it is mainly a retail and commerce neighborhood, many people have considered Downtown Core their home; however, if you want to live here, too, then you must be reminded that buying a real estate property in Islington-City Centre West as convenient because this comes with a huge price.
Regardless of your budget, you'll have a great time looking for Properties for Sale in Islington-City Centre West. The working class favors the midtown -which is suburban- but still manages to keep the enjoyment that characterizes city life. Through a 20-minute journey via public subway from the Midtown, you will reach downtownIslington-City Centre Westfast and simple if you happen to work here.
According to the listings of MLS, the location of these Property Search has a great level of security and the overall community has a strong peace and order. Couple these attributes with the fact that schools are easily accessible from every corner of Islington-City Centre West and you'll come to the conclusion that the city is ideal for households with young children. It is also good to learn that you can live in a friendly community here.
There are hundreds and tons of thousands of result that show up when you make a fast search of Properties Search. in North America, it is believed that the Islington-City Centre West real estate market is one of the most exciting with numerous appealing offers. By this revelation, it's believed that searching for a house can be a really difficult job for most individuals and investors. Thus, it's great that you filter the search based on your budget, desired neighborhood and other interests to be able to get excellent results.
Some have been led to believe that Islington-City Centre West is too expensive to buy a home in or purchase property in, but nothing could be further from the truth. It won't take much time looking Properties for Sale in Islington-City Centre West before you find a few real diamonds, including some of the more exclusive and affluent communities.
You can use the information you find to have the insights you need about the kinds of properties, variations of the neighborhood, and the heartbeat of Islington-City Centre West.
Carrying out a search by yourself might prove a bit tiresome. The great news is, there are agents and realtors to help you. It is wise to get an expert while you are trying to find the ideal Properties for Sale for you. The real estate market is a giant. You can be lost in the maze if you don't have experience. An online search will make you confused more and more as you go through the web sites. It is best to let an expert manage it instead.
Islington-City Centre West is very much a metropolitan city and is one of the major business communities in the province. The industry is huge in Islington-City Centre West, but it also has a fair share of cultural and entertainment amenities as well.
Islington-City Centre West has a prosperous economy with good prospects for a good career. The minimum wage was increased in January 2017 and then again in January 2019, and the average pay in Islington-City Centre West is one of the highest in North America – not just in Canada.
The cost of living in Islington-City Centre West is high and that is known to many. Nevertheless, there many opportunities that you can pick and choose from when you search for Islington-City Centre West Properties for Sale.
Always remember that when you are searching for houses to live in rather than for investment, you should endeavor to look for comfy neighborhoods. Thus, during your search for Properties for Sale in Islington-City Centre West, always remember to have this area of interest in mind.
Islington-City Centre West has many places for you to live in, and they will let you live the type of lifestyle that you'd like to live right away from casual to modern.
Islington-City Centre West was lately named among the greatest cities for entrepreneurs in North America. It hosts one of the largest technological startup community in the world. The city of Islington-City Centre West is also well-known among everyday businessmen because of its robust economy. This is the reason why securing one of the Properties for Sale gets pricey. in the long run, however, every purchase will show to be worth the investment.
The Downtown core boasts of a robust economy and this has attracted many people. There are a lot of young professionals present at the heart of the city and they are all aimed at maximizing the opportunities to create a name for themselves in their various fields of interest. The businessmen are availed the opportunity that are given by the moneyed professionals. It is not strange to see companies stay up to 2:30 AM in the Downtown. On other occasions, these companies can stay up to 4 AM if it is legally authorized.
That might be perfect for those seeking Properties for Sale in Islington-City Centre West that are younger, part of the millennial generation, and those that are most interested in nightlife – but it might not suit those with young families, more established families, or those that wish to slow things down without losing the opportunities and attractions that Islington-City Centre West has to offer.
Properties for Sale in the outskirts of the city are great for people on a budget. These houses are removed from the urban rush of Downtown Islington-City Centre West but still gets access to similar amenities. To go to the heart of the city, all you need to do is wait a few minutes in the efficient subway transport facilities. The other benefit of these houses is that they are significantly cheaper than their equivalents nearer to the city core.
These lines allow commuters to go from the outer places of Islington-City Centre West, the more suburban neighborhoods, into the heart of the city to work and take pleasure in all of the attractions it has to offer while living in some of the slower paced, cleaner, and safer places of the municipality.
Public transportation is one of the best things Islington-City Centre West has to offer when you're looking for Properties for Sale here. The TTC is responsible for running public transport in the GTA, with two main subway lines (one running south and north, and the other running east and west, with two other lines running out to east and west ends) and also a variety of bus lines and other public transport options.
You can anticipate that the properties found closer to the TTC public transport's mainlines will cost higher than the ones located farther. This in no way signifies that Property for Sale far away from the transit lines make transportation impossible- the TTC has done quite a wonderful job ensuring the city is well-serviced.
The overwhelming majority of people staying in Islington-City Centre West go without a private vehicle and that's because of how well the TTC deals with public transportation. A monthly pass to use all TTC operated transportation options is about $150, far less than anyone would pay for even the most inexpensive car – and that's without breaking down all the extra cash you have to throw at your car on a month-to-month basis only to own and operate it.
RLP Maximum
7694 Islington Ave, 2nd Floor Suite 220
Vaughan, ON L4L 1W3
Tel: (905) 856-7514
4.4 / 5 stars – based on 51 reviews
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BlackBerry low budget handset Z3
Z3 marks start of new direction
It's well documented that BlackBerry is hardly the company it used to be. Sales have dropped off and where once the company was revered in much the same way as Apple and Samsung, it's now rather talked about in terms of its past successes.
Its (latest) bid to turn things around appears to be kicking off with the launch of the Z3, a low-cost touchscreen device that it hopes will revive its strength in emerging markets. Revealed with a launched in Jakarta, it would appear Indonesia is exactly the kind of market in which it's hoping to bring back the good times. Retailing for under $200, this is arguably the handset on which much of BlackBerry's future depends. In the words of CEO John Chen: "If the market doesn't receive this product well, then we definitely have some negative issues to deal with." Which, dear reader, is what you call understatement.
Indonesia has become an important market for the company and should this prove a success there, the Z3 could be brought to other markets. Also look out for the BlackBerry Classic handset later this year, which marks the return of the non-touch screen device for the firm.


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I have an Antique Sound Labs MG Head DT headphone amp but did not use it for the test. This amp sounds great, but as I said, these headphones are not very bassy regardless of the amp. Everything else about the frequency response is wonderful, though.I should say that I prefer what is most likely an "exaggerated" bass response in headphones. I used to have various Koss phones and compared to the Sennheisers they had very warm, ear-massaging bass, but the clarity of the HD600s is much much better. I do kinda miss that low end pressure, though.
FWIW, NAD has a new 50wpc integrated that's gotten big praise for its sonics in The Absolute Sound, the 320BEE, $399, and it seems to have it all: tone controls, headphone input, remote control. The specs look great: http://188.8.131.52/info/NAD_C320BEE.pdfI'm interested in one for myself for a second system. Have you heard about it?
DVV, so you've actually heard this model? Didn't it just come onto the market, or are we way behind in the USA?Regardless, thanks for the heads-up. For that price, I might be willing to overlook some minor quibbles for a second system. I'm looking at something down the road anyways to give my wife something to use upstairs. Was the NAD fully broken in? Is the Rotel fully integrated competitive price wise? My personal experience with Rotel is very good build quality, good but uninspiring sound. You are right on the money when describing the lack of ambient factor (air) with Rotel. Maybe it's the resistors.
Sounds like the comments of someone who prefers tubes to solid state
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Guatemala seeks to implement the Grow Up Healthy nutrition and health project to combat chronic malnutrition
The Government of Guatemala is seeking to implement a multi-annual programme entitled 'Grow Up Healthy', which aims to help combat chronic malnutrition in seven priority departments, an official source said today.
"This plan aims to improve selected practices, services and behaviours known to be key determinants of chronic malnutrition, in the priority intervention areas," said Julio Héctor Estrada, head of the Finance Ministry during a meeting with elected members in the Congress of the Republic.
The project aims to strengthen primary care services, promote behavioural changes in families and communities and improve access to safe water and sanitation, among others. Grow Up Healthy will be financed by the World Bank through a loan of 100 million dollars and will benefit communities in the departments of Totonicapán, Sololá, Quiché, Huehuetenango, Chiquimula, Alta Verapaz and San Marcos.
"The ability to invest close to 800 million quetzals over four years in seven departments will help us reach areas of need in those departments," said the official.
The loan needs to be approved by the Legislature for the Ministry of Public Health and Social Assistance to then implement the initiative. "We conducted a trial in ten municipalities of Huehuetenango that demonstrated that this programme can reduce the rate of chronic malnutrition," said Health Minister Carlos Soto.
In addition, to ensure transparency and efficiency in the use of resources, the World Bank will conduct quarterly and annual audits of programme implementation. According to data from the Sixth National Survey of Maternal and Child Health (2014-2015), 46.5 per cent of children aged under 5 years suffer from chronic malnutrition.


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Nonzz Co Ltd wholesale mink lashes Factory is engaged in 25mm lashes line since 2010. During the past years, we are keeping on studying and developing our technique as well as our product quality. We are specializing in 25mm mink lashes manufacturing, custom eyelash packaging, developing and export trading.
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Braintree Town: Devonshire signs up seven more as squad returns to training
PUBLISHED: 17:01 01 July 2011
Gavin Ellis/TGSPHOTO c/o 27 Plaiters Way, Braintree, Essex, CM7 3LR - Editorial Use ONLY - FA Premier League and Football League
PLAYERS at Braintree Town have reported back for duty, as Alan Devonshire continues to assemble his squad
Football – Blue Square Premier League
PLAYERS at Braintree Town have reported back for duty, as Alan Devonshire continues to assemble his squad ahead of a first season in the top flight of non-league football.
The Cressing Road outfit began pre-season training on Thursday evening and amongst the ranks were six of last year's Blue Square South league winners.
Signing up for another year with The Iron are Nicky Symons, Matt Paine, Kenny Davis, Scott Shulton, Sam Lechmere and Ryan Peters.
Devonshire has also secured a new name in the shape of 23-year-old defender David Stevens from Hampton & Richmond Borough.
"The lads have worked hard in their first session and they've all looked after themselves during the summer. It's great that David has joined the club and that so many of last season's squad have decided to stay with us."
More good news was the return to training of forward Jamie Guy. The popular 23-year old striker played an active part in yesterday's session and is working hard with physio Steve Gracie on his rehabilitation.
Devonshire added: "Jamie's working hard and will be included as soon as he feels ready. When you think what he's been through over the past few months, his attitude has been superb."
One player has departed the club however. 30-year-old striker Cliff Akurang has decided to remain in regional football.
If you value what this story gives you, please consider supporting the Dunmow Broadcast. Click the link in the orange box above for details.


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Disney Store Mickey and Friends Ladies' Halloween T-shirt
Mickey and friends look ready to scare on this spooktacular tee! Featuring the 'Boo Crew' in their Halloween costumes, the cotton tee is perfect for sporting effortless Halloween style.
Magic in the details...
- T-shirt features Mickey and friends in Halloween costumes
- Artwork features: Mickey, Minnie, Donald, Daisy, Goofy and Pluto
- 'Boo Crew' wording
- Ribbed crew neck
- Matching T-shirt available for kids
- T-shirts sold separately, subject to availability
- Created for Disney Store
The bare necessities
- 100% cotton, excluding trims
- Machine washable
- Warning: keep away from fire
UK Standard Delivery: £3.95, FREE on orders over £50 (Within 5 working days*)
UK Express Delivery: £5.95 (Next working day* if ordered by 4pm)
UK Click & Collect: £2.95, FREE on orders over £50 (Within 5 working days*). Please see Click & Collect for details.
International Delivery: We deliver most items to a selection of countries. Please see International Delivery for details.
Disney Home Entertainment (Movies): £1, if your basket holds only Disney Home Entertainment (Movies).
*Selected postcodes may take additional time, please see Delivery Information for details.
For Delivery in the UK you will be notified of a 2 hour Delivery window. Please see here for details.
Returns: We offer up to 30 days return on most of our products, please see our Returns Policy for more information.
FREE DELIVERY on orders over £50
1)Get a selected gadget pencil case for £7.99 (usually £12.50) when you spend £10 or more. 2)Product item numbers are: 466030744411, 466030744589. 3)Available online at www.shopdisney.co.uk 4)Offer valid between 18.09.2020 to 04.10.20 (inclusive) or until stocks last. 5) Discount will be applied at the checkout. 6) Items must be purchased in one transaction. 7) The Offer does not apply to purchases made before or after the Dates. 8) No purchase voucher can be given for this offer. 9) We reserve the right to terminate this offer at any time if Terms and Conditions of the offer are not fulfilled. 10)Nothing in these Terms and Conditions shall be intended as precluding the exercise of your statutory rights. 11)Your participation shows that you have read and agreed with the terms and conditions of the offer. These terms and conditions are subject to UK law.


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Optimize your web store and take your site's SEO to the next level with Execula SEO Plugin. Easy Generation of Mobi… https://t.co/1RtPp3bZcX
Phoenix Arizona, USA, 85048-8702
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There are plenty of experienced assassins patiently awaiting the arrival of Hitman 2 this November, but there are also many out there who don't know the first thing about what it takes to be a top-notch hitman. There are plenty of guides contained in the vast expanse of the internet, but those looking for a quick introduction to the world of Hitman need look no further than the game's newest trailer. Today, WB Games has released the first in a series of "how to Hitman," with a focus upon immersion, options, and outcomes.
The game's sandbox is the star of this video; it's narrator makes a point of pointing out exactly what effect the player can have upon the world and how it will react to their presence. As with previous games in the series, it looks like Hitman 2 provides its players with many different avenues for completing their jobs. At the racetrack shown in the trailer, options included fixing the race to get the target into an exposed position or just sabotaging their car directly.
The game's NPCs also appear to have received an upgrade this time around. Trailers of this sort should always be taken with a grain of salt, but it looks like IO Interactive has put a great deal of effort into them. Many unique and detailed faces are shown, and most NPCs appeared to have their own lines of background chatter. The trailer claims that NPC characters will react to changes in their environment, including odd noises. The world is described as "meticulously designed," so perhaps players will indeed be able to manipulate the NPCs through less obvious means.
Blending into one's surroundings and taking full advantage of them has always been an important part of doing well in past Hitman games, and it looks like the same holds true here. This extra layer of immersion just makes it that much easier to get into character.
Hitman 2 launches for PC, PlayStation 4, and Xbox One on November 13.


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Illusion Diamond Bracelet
This 18k gold bracelet features a train of emerald white diamond clusters made up of five baguettes and four round cut diamonds. The piece is held together with a ladder clasp and contains 6.02 carats worth of diamonds.
Gold 18k: 18.50g
TDW: 6.02ct
Round Diamond: 0.83ct
Baguette Diamond: 5.19ct
Length: 6.5"
** Please note all SARA WEINSTOCK product is 18k Gold and Diamond Quality is VS-SI G-H Color **


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Fresh Farmhouse Bedroom Ideas Country Bathroom
Fresh Farmhouse Bedroom Ideas Country Bathroom
Classic Indian trunks cladded along with flat iron straps plus metal medallions, farm house elegant rooms get more style just by applying ancient wood made pray chests reconstructed as sensible espresso furniture who have a added price of storage. Many will be delicately comprehensive together with monsters in addition to farm pets having tales with the Liven Direction yet others tend to be colored having rustic aqua aging harking back to Jodhpur the actual Blue City. Troubled colour senses normal around the retro traditional cabinets made out of re-cycled older doors, antique woods which are thus fantastically aged not to mention varnished. Cusine furniture manufactured from vintage doors detailed with latches along with straightener porn stars are generally accented beautifully together with wrought straightener chairs.
Classic rural aged archways move your kitchen area mantel in to a press release, the green leaves within metal plant containers attracts focus on a hands created element and also the normal rinsed patinas. Decorative uneven tribe family table sporting men can give the dining tables a tasteful, antique bohemian life panache that work well having a ton of colors. Pick up an old planter and also pack together with stunning bachelor's pad yard plants or perhaps herbs.Vintage servings in addition to rural metal urns used as a lead filled with holiday pumpkins, pines in addition to its heyday sticks take in the outdated pad charm.
Add farmhouse-inspired adornments, created in the home wreaths and flower arrangements providing a stunning private touch. Your antique previous chakra bookcase brings immediate attraction, offering a spot to help keep guides plus your vacation collections. Prolonged timber umbrella boxes inside upset blues as well as green vegitables applied following your bed or even because eye-port console desk positioned in the actual space, you can enjoy the sun's rays although looking through your favorite book.
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Carry from the farm house motif into your garden center by way of hanging a classic jharokha windowpane filled up with infant pictures. The particular windows 7 have a cottage-chic raise together with handloom fabric throws woven by way of worksmen inside organic 100 % cotton fibres and also lively colors. Add old old-time containers packed with decorative, in season flower arrangements with of the question sill. Utter sari draperies are great for home windows 7, morning meal nooks or some other spaces where natural light offers alluring fashion and a few privateness with out stopping a sunshine.
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If you think of a farm house, the initial idea is most likely exactly what a household which has a disaparate entrance porch. The following roomy porch may seem to beckon the particular passersby in the future sit down plus take it easy in the colour tone plus drink about a great interesting tumbler of iced tea. Absolutely nothing is much more appealing which an extensive the front porch with swaying seats that have secure seat covers in every seat. This is where your cultivator will expend the vacations because is calming regarding his family. If you are designing your current region house blueprints keep this awesome attribute of an country farm house within mind. Without this commodious and comfortable top porch, truly would not be a new farmhouse.
A lot of farmhouses in which you see near you undoubtedly are a basic rectangle shape. In addition, these kind of farmhouses are usually two experiences together with the bed rooms lying down to the subsequent story. Nevertheless, if you have a problem with staircases i really enjoy seeing, you can even examine out and about home programs regarding rnch which has a walkout cellar instead. At this moment even if you tend to be building the farmhouse, it doesn't signify you need to sacrifice quality to the luxury items that you place on the inside of your home. You may bring in a whirlpool bathtub with the master bath. Or you might perhaps add wander inside closet regarding each of the sleeping quarters rather than just for the master. In case you planned to truly opposed to the grain you might buy a advertising place in the your for your enjoyment of your respective family.
Regardless how you choosed to design your goal land farmhouse, you will come to get pleasure from the best thing about like an original item of structures for countless years so that you can come. The land farmhouse may turned out to be called the household's tiny bit of escape which is typically considerably needed. After you arrive at your farm house the sole thing with all of your imagination'will be relaxation.
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Some have the organic born skill a lot of other individuals make time to study the skill. A few may see how shades combine completely for instance gourmet coffee as well as milk. It can be interior designing.
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The farm house dining table is actually formed, intended as well as produced in the basic situations from the farm life of the particular 1700's. While there're usually large, rectangular lead, and made involving 100% wood (whether pine, walnut or even pine), these people are extremely stable and also are inclined to express feelings of rustic elegance. Whether or not you need a geniune farmhouse dining table created sometime in the particular 1700's and also you ought to be far more budget conscious plus you need a defined look-alike, there are many gorgeous kitchen tables to settle on from. Plus the most pleasurable thing you can do is definitely renovate ones wood made game tables and earn it seem antique. If you would like achieve that endured dry out glimpse on your table, just simply dash white vinegar overall the particular surface of table. Perform exactly the same up for grabs lower limbs along with let it absorb for a while just before including wax in order to it. The particular sealer can dye along with of your wood.
For the more sophisticated look, search to get a reproduced espresso table by using straightforward black or brown color. They could be either sophisticated by using set off knee style or even circular topped and also clear.
The right place to be able to put your table is actually of the question as well as near collapsable cup sections where ample volume of lighting style can reflect along with show your table's elegance. According to the function on the table, you can include a bit center associated with woodworking for much more episode as well as maintain it basic hence you should use the outer lining to put training books or your coffee mug connected with coffee. In order to use the dining room table as your main living area, dangle your wood chandelier previously mentioned regarding an increasingly exciting feel. Also you can follow hues along with spruce up you farmhouse by spot, such as: set lime chairs by way of a fire, a new discolored set of courtyard ergonomic chairs and also platforms external the backyard together with green plants quietly, green color shades as well as bed blankets for the visitor bedroom.


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Always FREE! For books and games we cover the cost of shipping both ways.
So, I can rent eBooks and printed textbooks using iFlipd?
Yep! iFlipd uses a pay-as-you-go model on both eBooks and Print books, which means you can rent textbooks for seven days at a time for a flat fee. The rental automatically renews every seven days even days until you return the book, or reach the designated number of "weeks to own" shown for each book. It's the ultimate in rental flexibility. Rent any book for any amount of time, and never pay more than the list price.
Do the video games come in the case?
Yep! Games come in the original case when available. If you pay off your game you get to keep the case, too.
How many video games can I get?
You can have two (2) games out at one time with iFlipd. Want to get more games? Just return one or use the Pay Off feature to buy it and you'll be able to order more.
What forms of payment does iFlipd accept?
We currently accept credit cards, debit cards, PayPal & Venmo (mobile only). We may occasionally ask for multiple forms of payment so we have a back-up payment method on file should funds run low in one of your accounts. Your weekly charges will show up as a weekly payment to BT'IFLIPD.COM. If you are using your parent's credit card, you may want to alert them that there will be a small charge each week coming from BT'IFLIPD.COM
How am I billed?
The rental fee is based on the price per week shown for the item, and recurs weekly until either the item is returned (be sure to go through the return process in your account), or you pay off the item. If you keep the item for the total number of weeks-to-own shown, charges stop and you own it.
Your payment method is charged for the first week when your order is placed. For eBooks, the rental term starts immediately after order is placed and the billing cycle recurs every 7 days until the book is returned or owned. For Hardback/Paperback books, games and access cards, the rental term starts when the textbook is scanned as delivered by the shipping company. The next weekly billing cycle starts 7 days after book is delivered and recurs every 7 days until the book is returned or owned.
What if I don't have enough funds on my credit card account to cover the charge of the rental
You are responsible to maintain a valid method of payment on your account. If you default on your weekly payment for more than two weeks you will be charged a $10 missed payment fee for each item you default on. We really don't like charging missed payment fees, so we'll send you email messages if you miss a payment to remind you to update your payment method. After 30 days of missed payment the full amount of the book will become due and you will be handed over to a collections agency as agreed to in iFlipd's terms and conditions.
How do I return my print book or video game?
Returning your physical book or video game is easy:
- Select the book/game you want to return from your Collection of your Order History page
- Click the Return button.
- Go through the return process and download the return label
- Print the return label (Important: you must use the label provided by iFlipd—only when it is scanned does the rental stop)
- Pack up the book/game - One book/game. One box.
- Ship it.
One book or game. One box.
It's important to package one book/game, per box, per return label. We determine when to stop billing your account based on when the return label is scanned at the warehouse. If you are returning more than one book/game you should put them each in their own box with their own return label. Do not put them in the same box with one label or you will continue to be charged for the one who's shipping label is not scanned.
How do I return my iFlipd eBook?
To stop renting and return your eBook, follow these easy steps:
- Login to iFlipd and click on the book from your Collection or Order History
- Click the Return button.
- You will no longer have access to the eBook and your charges will stop
You can rent this same book in the future and we'll keep track of what you have already paid towards owning it.
Can I return my access card?
No. Since access card codes can only be assigned to one person we can't accept returns. You will be charged for the full price of the access card across the number of "weeks to own" shown in the listing on iFlipd. You can also pay off your access card early if you like.
How do I track my order?
Easy. We send you a shipping confirmation email with a tracking number when the book is shipped. If you miss the email you can log into your account and go to your Order History page to find a tracking number.
These POINTS you keep mentioning, how do I get them and how do I use them?
At iFlipd, points are like currency for rewards. Here's how to use them.
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Account Login
Knowledgebase : Account Information
Can I open an account with you from anywhere in the world?
Posted by Administrator on 09 December 2016 10:47 am
Yes, you can open an account with us from anywhere in the world. You can be a citizen of or reside in any country of the world.
Since we are offshore, we are not required by law to check the source of funds invested with us and are not obliged to reveal any personal information about our customers to anyone.


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PCDJ DEX 3.14 – professional DJ Software
PCDJ DEX 3 is professional DJ Software for Windows and MAC. It allows you to seamlessly mix music, music videos and host karaoke shows. The user interface emulates the look and feel of CD Decks. Also includes mixer controls much like you find on physical DJ mixers.
PCDJ DEX 3 gives you full control over your media, allowing for more creative freedom while mixing than ever before. With the beat-grid based automatic beat mixing it's easy to blend tracks. That allows you to focus on the other aspects of your mix.
BUY NOW PCDJ DEX 3 (Activation For 3 Windows/MAC PCs)
PCDJ DEX 3 offers no-latency playback. Loops, hot cues, and all playback features are ultra-responsive. Use PCDJ DEX 3 with a keyboard or mouse, or use one of the 65+ supported DJ controllers for tactile hands-on control. So download PCDJ DEX 3, import you tunes, and cue up your imagination. PCDJ DEX 3 is the complete DJ mixing software solution.
Use a traditional 2-Deck interface with or without video mixing controls. Or layer in your mix with one of the included 4-Deck skins. BPM beat-sync, looping, key-lock, hot cue points, filters and effects all work flawlessly whether youíre mixing audio or blending music videos.
PCDJ DEX 3 includes an advanced media file browser for all your music, music videos and karaoke files. The included library filters allow you to view only the file type you want to work with, and the fast search feature displays results as you type. Create custom playlists or generate lists from directories on your hard drive. Album art and color coding makes it easy to find the songs you're looking for. Playlist playback automation is built right in. Engage Automix or Shuffle Play if you need a break.
DJ Controllers provide hands-on tactile control over PCDJ DEX, allowing for more creativity while mixing. Over 65 DJ controllers from popular DJ equipment manufacturers are natively supported. That means zero-configuration for you so you can get into the mix right away. When you press a button, twist a knob or scratch a platter on your DJ controller. PCDJ will react immediately, without latency.
PCDJ DEX 3 Features:
- Up to 4 DJ decks (two for video and karaoke) with professional grade mixer and playlists
- Two mode skin, complete with Audio and Video Tabs
- Skin support – change the appearance of PCDJ DEX 3
- Fully manual or automatic mixing (one-click beat-matching)
- Video mixing (including pitch, break, reverse, scratch video)
- Video effects and Video transitions
- Karaoke Singers List. (click for more info)
- Timecode vinyl/CD support
- Robust library with format filters, search as you type, and tag editing
- Change font dynamically (in real-time) in playlist/browser (press on the list to have focus and then press +/-/0 on your keyboard)
- Seamless intelligent looping and beat-skip
- Automatic grid-based BPM detection with batch processing
- Vinyl simulation including scratch, pitch, reverse play, and brake
- Headphone cueing and monitoring
- Support for professional VST effects
- Key stepper – configurable (full/half/quarter steps) with digital readout
More Features:
- Analog input for microphone (with talk over), turntables, or CD player's
- Pitch scaling for harmonic/key mixing
- Advanced auto-mixing including Mix-In/Mix-Out (Cue In/Out) points
- Perceptual automatic gain (volume control)
- Sample player – load up audio clips and trigger them
- Karaoke CDG (MP3+G Zip and uncompressed) support
- Record your mix to MP3, WAV or AIFF
- Key-Lock (Master Tempo) – Very high quality option available!
- ASIO/CoreAudio low-latency support
- Browsing system with unlimited lists, disk explorer, database, and iTunes library import support
- Load the whole song in RAM for instant access
- Audio-CD support on Win/Mac
- Reads mp3, m4a, wav, aiff, ogg, cda, mpeg, avi, mov, flv, mkv, wmv, flac and more!
- Works cross-platform equally well on a Windows computer as it will on a MAC!
- One purchase allows activation on three computers
Changes in PCDJ DEX 3.14:
- macOS Catalina support (NOTE: If you receive this warning "setup_dex3_3.14_mac.pkg can't be opened because Apple cannot check it for malicious software. this software needs to be updated. Contact the developer for more information" when installing to macOS Catalina please follow the steps on Apple's website to install DEX 3)
- OpenGL to Metal (macOS Catalina Graphics API)
- Using new modern way to access Music (iTunes) library
- Moved Location of data (PCDJ-DEX3) folder to prevent various access/saving issues
- Added button to access user data folder in DEX 3's options (top right of General tab)
- Added new setting: "Use max framerate for video/graphics" (works on both Windows and Mac)
- Added Karaoke "Singer Search" in search window. Click the "S" button in the search windows and then type in one of your karaoke singers names to display their singer history immediately.
- Extensive optimizations, Performance improvements, and bug fixes
Changes in PCDJ DEX 126.96.36.199:
- Fixed Shader Support due to recent change of protocols at ShaderToy.com
- Various performance improvements (mainly related to communicating with SoundCloud and Party Tyme services).
Homepage – https://www.pcdj.com
Supported Operating Systems: Windows 7, 8, 8.1, 10 (32-bit, 64-bit).
Size: 63.7 MB
DOWNLOAD PCDJ DEX 3.14 Trial For Windows x86
DOWNLOAD PCDJ DEX 3.14 Trial For Windows x64
DOWNLOAD PCDJ DEX 3.14 Trial For Mac
DOWNLOAD PCDJ DEX 2.6.5 Trial For Windows


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Patanjali products have been picking up a lot of prevalence as they bargain in a wide cluster of products which range from cosmetics, nourishment merchandise, masalas, juices and that's only the tip of the iceberg. In the event that you pick to make healthy skin merchandise, you'll have to figure out what sorts of healthy skin products which you'd love to make and instruct yourself however much as could be expected. Systems administration with others that are keen on making healthy skin products is likewise an extraordinary method to get important comprehension.
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Facts Summary:
The Kerch Black Sea Shad (Alosa immaculata) is a species of concern belonging in the species group "fishes" and found in the following area(s): Bulgaria, Georgia (Eurasia), Republic of Moldova, Romania, Russia, Serbia, Turkey, Ukraine. This species is also known by the following name(s): Alosa pontica.
Featured Article
Ten creatures that may become extinct in the next 10 years1. Leatherback Sea Turtle
Leatherback sea turtles have been around since pre-historic times. And unfortunately, if the species is allowed to vanish, scientists believe it will foreshadow the extinction of a host of other marine species. It is estimated that there are less than 5,000 nesting female leatherback sea turtles in the Pacific Ocean today, down from 91,000 in 1980.
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The airline "Aeroflot" has once again cancels its flights.
According to available data Avia.pro, 28 and 29 November airline "Aeroflot" will cancel some of its flights from the capital's Sheremetyevo airport. The main reason for the cancellation of flights is the presence of adverse weather conditions, however, passengers seriously outraged by such behavior airline management, since the actual threat to air travel there.
It should be clarified that in the current month "Aeroflot" airline has already canceled a few dozen of its flights due to adverse weather conditions, which created a lot of trouble for the passengers, however, performing duty in front of them.


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This particular article explains why organisation furnished team medical care insurance will almost certainly disappear. Fitness Care Reform along with variables will do to employer given group health options what the 401k and IRA did to pension ideas. Element one handles why it would make perception for employees to drop small business offered group medical insurance and request coverage inside of the Particular person / Family unit Medical health insurance Industry.
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At present, group many advantages and group health and fitness schemes on the work destination have gotten substantially more cost-effective. They however go away plenty of area for confusion for most workers, though. Questions about value and level of quality of provider apart, plenty of employees please don't thoroughly understand how they even succeed. So here is a short primer that can help you understand how they give good results.
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Jambalaya, Cajun hospitality and high-quality music! This can be what will greet all student team upon arrival in New Orleans or N'awlins (because the locals lovingly refer to their town). To be ranked #1 in 10 categories in Vacation & Leisure Magazine's 2009 "America's Favorite Cities" study, the men or women of New Orleans realistically mean whatever they say…"Les Bon Temps Rouler!" (Let the Positive Occasions Roll!). Completely melding French, African, Spanish, and American cultures, the result can be a exciting city brimming with educational museums, exciting attractions, Cajun/Creole food, fabulous music, specific historical webpages and, of class, Mardi Gras.
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Joining and participating in teams on LinkedIn is consistently ranked around the best 5 options that folks say ultimately will help them produce and model their small business as well as locate the just right profession. Groups can be a great way to: Discuss, share, and interact having a team of like-minded people today who've typical pursuits and therefore are located roughly the earth or perfect into your personal neighborhood, Raise the size from the population you…
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Using your own private meditation group is an excellent method to fulfill new buyers but it's also a terrific strategy to discover new meditation procedures. While you begin your meditation journey you are likely to realize new techniques to meditate and everyone could have their particular hints plus a meditation group is an excellent route to know.
Staff just about invariably want that wages and any bonus paid be determined by unique energy. There're scenarios, yet, of associated work where teamwork is fostered, production enhanced, earnings per worker raised, and expenditures lowered by a suitable group payment scheme. Ordinarily, beneath unique incentive plans, just about every worker strives to enhance his have output independently from the show results of other folks.
In a natural way talking many people link with just about every other by some kind of group. Via the internet, offline, on purpose or happenstance, we link by way of teams. This is relevant to ace group fitness practice test.
Social networking sites became an more and more formidable marketing resource for businesses both large and minimal. Some have some programs and positive factors, focusing on visuals, info-bites, and purchaser assistance rewards. But nevertheless, LinkedIn has a significantly more centered reward: networking using your viewers.
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Red seaweed
Dasya sessilis
- tip of branch 2
Red seaweed
Dasya sessilis
- tetrasporangial stichidia 1
Red seaweed
Dasya sessilis
- tetrasporangial stichidia 2
Red seaweed
Dasya sessilis
- tetrasporangial stichidia 3
Species found on pontoon at Newlyn Marina, Newlyn Harbour, Newlyn, Cornwall. 02.11.14.
It is very likely the specimen here is a species called Dasya sessilis, a non-native species from Japan. The find needs to be verified but if it is then this will be a new UK record. The species is already found in Spain, Portugal and France.
I'd like to thank Mike Wilcox for drawing my attention to the possibility. On sending images to various algae experts across Europe and the USA, their opinion was the same. Attempts will be made to re-find the species at Newlyn for verification in the USA.
APHOTOMARINE supports open source data recording and sharing for the benefit of wildlife, recorders, research, science and education. The project recommends the following websites and works with the following bodies and organisations.
The Marine Biological Association or MBA, based in Plymouth, is one of the world's longest-running societies dedicated to promoting research into our oceans and the life they support. Since 1884 the MBA has been providing a unified, clear, independent voice on behalf of the marine biological community.It has a growing membership in over 40 countries.
The National Biodiversity Network or NBN is a charity that supports open source data sharing and recording supporting conservation, science and education. "Why do recorders need open source?". Simply because it supports the core values of wildlife recording and the free use of records and data over a very wide network that includes partners like the Natural History Museum.
The taxonomy used here is based on that of the following database, which is also used by the MBA, NHM and the NBN.
The World Register of Marine Species or WoRMS.
AlgaeBase is a database of information on algae that includes terrestrial, marine and freshwater organisms.


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(HealthDay News) — Despite an increase in the number of U.S. medical school graduates, over the past decade, the percentage entering graduate medical education training has remained stable, according to a research letter published in the Journal of the American Medical Association.
Henry M. Sondheimer, MD, from the Association of American Medical Colleges in Washington, D.C., and colleagues identified all graduates from the Association of American Medical Colleges Student Record System. They examined whether graduates from all medical schools entered graduate medical education training; the percentage of graduates unplaced in graduate medical education was assessed overall and by race/ethnicity.
The researchers found that during the study period there were 186 937 graduates, increasing from 15 762 in 2004-2005 to 18 705 in 2014-2015. The percentage of graduates unplaced in graduate medical education during the academic year of their graduation from medical school was stable over time, with a mean of 3.0% (P=.18 for trend).
Over time, there was an increase in unplaced black, Hispanic, and non-U.S. citizen graduates. Compared with whites, racial/ethnic minority graduates were consistently less likely to begin graduate medical education the year they graduated. More than 99% of all graduates entered graduate medical education or were found in medical practice in the United States within 6 years after graduation.
"As the number of U.S. MD graduates continues to increase with the creation of new medical schools and the growth of existing schools, these trends should be closely monitored," the authors write.
source: http://www.endocrinologyadvisor.com


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KNOWLEDGE DROP: Police Brutality Hoodie
Brand Tunnel Vision
Knowledge Drop: Police Brutality Hoodie
Black or white hoodie with rainbow multi-toned print on front reading:
- Black people are 2.5-2.8x more likely than white people to die by violent force at the hands of law enforcement in the US.
- Black victims are more likely to be unarmed (15%) than White victims (6%) when killed by the police.
- Black people stopped by police are 21.3% more like than their White counterparts to be involved in an interaction with police where a weapon is drawn.
- Black people are 53% more likely to experience use of force by the police than White people in general.
- When officers report civilians have been compliant and no arrest was made, Black people are still 21.3% more likely to endure some type of force.
- 24% of Black people killed by the police were not attacking police at the time of their death, compared to 17% of White people killed by the police.
- 1 in 1,000 Black boys and men in the US will be killed by police in their lifetime.
(Yale University, US National Library of Medicine, National Institutes of Health, US Department of Justice, Rutgers University's School of Criminal Justice, University of Nebraska at Omaha)
Part of our Knowledge Drop collection -- pieces sold at cost with $0 profit to spread the word!
Tunnel Vision on sweatshop-free AWDis hoodie
This item is sizes in traditional men's sizing.