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How To Get Rid Of Light Colored Stretch Markss
Tsippora Shainhouse informed EXPERT that both teen men and women frequently develop extent marks. In teen girls, signs typically appear on boobs, buttocks, interior upper legs, and also hips. Men are most likely to discover all of them on their spines or edges. Expecting folks or even those that obtain body weight rapidly for any type of reason may also discover stretch results appearing on their breasts, tummies, upper legs, top arms, or buttocks.
" These spots can likewise create on the biceps and also upper legs in both women and also male bodybuilders that definitely function to establish notable, regional, hefty muscle mass over a brief time frame," added PHYSICIAN Shainhouse. Though they might certainly not be actually the sort of hand-me-downs you would certainly choose, a predisposition to acquiring stretch marks shows up to genetic." Some individuals establish extent marks while others do certainly not.
Newman. This indicates that if your parents or even brother or sisters have stretch results, you're very likely to create them as effectively, relying on your very own pattern of body weight increase or even growth. Any person who has actually ever before attempted to battle extent smudges knows that there are plenty of creams and also creams on the market place that case to cease stretch smudge in their paths.
" Stopping stretch smudges is testing due to the fact that there is no way to make the skin layer to develop much faster. Moisturizers may assist, however the scientific information is limited," pointed out PHYSICIAN Newman. Though topical therapies may moisturize and moisturize the skin layer area, DOCTOR Shainhouse said to INSIDER that they don't substantially build up and also defend the collagen as well as elastin in the deeper dermis, where is the stretch denotes cultivate.
How To Get Rid Of Light Colored Stretch Markss
Monning27/Shutterstock "You can't truly avoid stretch marks from establishing, other than through preventing episodes of considerable, fast weight gain, that will certainly flex skin also promptly before it possesses time to change," claimed DOCTOR Shainhouse. Keeping active and eating a well balanced diet regimen full of vitamin-rich meals can undoubtedly aid to sustain healthy and balanced skin generally.
" Diet regimen and also workout affects weight gain, and weight increase is what cause stretch results. However if a client has presently cultivated extent signs, no amount of diet or exercise will definitely assist do away with all of them," explained PHYSICIAN Newman. Stretch marks usually fade in time and become less noticeable throughout the years.
" Contemporary retinoids as well as pulsed dye lasers can easily help lower the color much more quickly. Fraxel lasers and micro-needling, as well as to a lesser level, topical retinoids, can easily aid activate collagen fixing and also regeneration rather, which can easily make stretch smudges appear less jagged and also boost their appearance," recommended PHYSICIAN Shainhouse. These treatments can help to diminish the exposure of stretch marks, but the AAD advises that no dermatological technique can easily eliminate all of them fully.
Newman told INSIDER that in most instances, operative clearing away the stretch sign affected area with a procedure such as an abdominoplasty is actually the only way to reduce all of them forever.
How To Get Rid Of Light Colored Stretch Markss
Many girls experience from stretch signs generally after pregnancy, yet that's certainly not the only cause for it. Male also have stretch results as well as thus do girls that are not pregnant. Extent marks take place because of a quick body weight increase or even fat loss. There is actually no denying the reality that extent marks can easily turn out to be actually very bothersome.
People commonly wind up resorting to numerous appeal treatments to acquire rid of extent scores. Nonetheless, few become aware that chemical-laden elegance procedures additionally come throughout with their own collections of side-effects. So as to stay away from the unsafe side-effects, one can easily offer utilize some helpful property remedies.
However, it requires a routine skin care program and strict specialty. Aloe vera is actually a plant that helps restore skin layer tissue and thus it possesses miraculous recuperation attributes. Take the fresh gel from the leaf as well as massage onto the region along with extent spots and also leave on for 20-30 minutes.
The very best time to make use of chocolate butter goes to evening, so massage it effectively into the skin layer and over a time period you will locate the stretch denotes lowering and fading away. The most effective opportunity to use cocoa butter goes to nightLemon extract's natural acidity assists cure and minimize marks as well as cucumber extract provides the amazing comforting impact leaving your skin layer clean.
How To Get Rid Of Light Colored Stretch Markss
Permit it get on your skin layer for approx. 10 minutes after which you can easily rinse it off utilizing hot water. Mix lime juice and also cucumber extract in equivalent components, and also administer the blend on the affected areasPhoto Credit rating: facebook/making organic cosmeticsUse almond and coconut oil in equal quantities to decrease stretch marks.
This house remedy is absolutely all-natural, which implies no damaging side-effects. Follow this solution consistently as well as keep an eye out for helpful results. Try it.( Likewise Read Through: Coconut Oil for Extent Marks: 5 Beauty Remedies That Work Wonders) Usage nuts and coconut oil in identical quantities to minimize stretch marksPhoto Credit scores: iStockApricots have excellent exfoliating possibilities, which create all of them really helpful when it involves recovery extent proofs.
Squash the fruit right into a paste and also apply this disguise on the extent mark impacted locations and also leave it on for 15 mins. Utilizing warm water, wash it off and afterwards duplicate the method everyday for a month to view end results. Pure apricot oil has skin invigorating properties and therefore helps in lessening extent signs.
Oranges have great exfoliating tendenciesBecause of their dried, withered up look, stretch marks require sustenance and dampness. Castor oil when massaged onto the skin will aid recover as well as smooth the marks little by little. Yet this is something that you need to continuously nourish the skin layer with. Castor oil when rubbed onto the skin will assist heal and also smooth the signs slowlyOver my twenty years of expertise in appeal, I have found the incredible result of the observing nourishing face mask in lessening stretch results -2 egg yolks, beatenJuice of one lemon2tsp oatmeal2tsp nuts pasteEnough milk to mix to a smooth insert: Mix all the substances well and also apply on the nose and also let it completely dry completely.
How To Get Rid Of Light Colored Stretch Markss
This should be done on alternating times. This face pack has skin gaining propertiesAs you may possess noticed while reviewing through my article, handling extent notes the all-natural method is actually not an over night wonder. It is going to demand your opportunity and also perseverance yet the results are going to be actually fruitful. So now that you possess some easy as well as practical natural home remedy to take care of persistent stretch scores, begin today.
She additionally teaches reflection by means of aromatherapy and arranges business shops for upsetting. She has her very own stable of 40 beauty items and proposes to launch all of them quite soon in the Indian market in addition to abroad. With this crusade of relocating back to attributes, Suparna relies on creating folks healthier and extra attractive the natural method.
NDTV is actually exempt for the reliability, efficiency, appropriateness, or credibility of any sort of information on this article. All relevant information is offered on an as-is manner. The relevant information, facts or point of views appearing in the short article do not demonstrate the sights of NDTV as well as NDTV performs certainly not assume any kind of responsibility or even liability for the same.
Extent marks are actually generally detected based upon an examination of your skin and a review of your case history. If your medical professional thinks a rise in your cortisol production, she or he may encourage added tests. You may certainly not such as just how stretch spots create your skin layer look, but they do not need clinical therapy.
How To Get Rid Of Light Colored Stretch Markss
If you carry out seek procedure for extent spots, know that procedures are only partly successful and also will not remove all of them totally. The following treatments are amongst those readily available to assist enhance the appearance as well as texture of extent results. None has actually been actually proved to be actually more regularly prosperous than the others. Derived coming from vitamin A, retinoids such as tretinoin (Retin-A, Renova, Avita) that you relate to your skin may improve the look of stretch marks lower than a handful of months aged.
Tretinoin can irritate your skin. If you're expectant or nursing, discussion with your physician regarding other treatment choices, since feasible side impacts of retinoid lotion may influence the little one. A variety of lighting as well as laser device treatments are accessible to help boost the growth of bovine collagen or elastin in your skin layer.
This form of treatment entails a hand-held tool that drafts crystals onto skin layer. These crystals gently get rid of a great layer of skin layer, ensuring the growth of brand-new, more-elastic skin. Partner with your physician to choose the absolute most ideal therapy or mix of procedures for you. Elements to think about feature: How much time you have actually possessed the extent marks Your skin style Convenience, as some treatments demand repeated medical professional check outs Price, as treatments to improve look (cosmetic treatments) typically aren't dealt with by medical insurance coverage Your requirements Several lotions, salves and various other products claim to avoid or handle stretch spots.
Extent marks often fade and also come to be much less obvious over time and also do not demand any type of particular self-care or house therapy. The tip that you can prevent or even deal with extent spots through wiping lotions, oils or even ointments on your skin layer is actually not assisted by sturdy proof. If you're expecting, consult your doctor prior to utilizing substitute items that claim to handle or prevent extent marks – How To Get Rid Of Light Colored Stretch Markss.
How To Get Rid Of Light Colored Stretch Markss
03, 2019 Program endorsements Korgavkar K, et al. Stretch signs while pregnant: An evaluation of contemporary deterrence. British Publication of Dermatology. 2015; 172:606. Cunningham FG, et al. Mother's anatomy. In: Williams Obstetrics. 24th ed. Nyc, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com (How To Get Rid Of Light Colored Stretch Markss). Accessed Nov. 5, 2015. Al-Himdani S, et al. Striae distensae: A thorough review as well as evidence-based analysis of prevention and treatment.
2014; 170:527. Lebwohl MG, et cetera. Striae. Therapy of Skin Layer Illness: Comprehensive Healing Tactics. Fourth ed. Philadelphia, Pa.: Elsevier; 2014. http://www.clinicalkey.com. Accessed Nov. 6, 2015. Picard D, et al. Incidence and threat variables for striae gravidarum. Publication of the American Academy of Skin Care. 2015; 73:699. Hussain HA, et cetera. Stretch marks and procedure effectiveness.
2012; 66( suppl): AB29. Hexsel D, et cetera. Superficial plastic surgery versus contemporary tretinoin on early striae distensae: A randomized, captain research study. Dermatologic Surgical operation. 2014; 40:537. Ud-Din S, et al. New understandings on keloids, hypertrophic scars as well as striae. Dermatologic Facilities. 2014; 32:193. Hernandez G, et cetera. Usage of a details anti-stretch mark lotion for avoiding or even lowering the extent of striae gravidarum (How To Get Rid Of Light Colored Stretch Markss).
International Journal of Aesthetic Scientific Research. 2013; 35:233. Brennan M, et cetera. Contemporary prep work for preventing extent marks in pregnancy. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000066.pub2/abstract. Accessed Nov. 6, 2015. Tsai TL, et al. Bosom striae after cosmetic enhancement. Aesthetic Surgical Treatment Diary. 2014; 34:1050. Valente DS, et al. Incidence as well as risk variables of striae distensae adhering to boob job surgical procedure: A cohort study.
How To Get Rid Of Light Colored Stretch Markss
2014; 9: e97493. Jeweler LA, et cetera, eds. Skin layer improvements and also health conditions in pregnancy. In: Fitzpatrick's Dermatology as a whole Medicine (How To Get Rid Of Light Colored Stretch Markss). 8th ed. New York City, N.Y.: The McGraw-Hill Business; 2012. http://www.accessmedicine.com. Accessed Nov. 6, 2015. Goldsmith LA, et al., eds. Anetoderma as well as various other atrophic ailments of the skin layer. In: Fitzpatrick's Dermatology typically Medicine.
New York, N.Y.: The McGraw-Hill Business; 2012. http://www.accessmedicine.com. Accessed Nov. 6, 2015. Saag KILOGRAMS, et al. Major adverse effects of systemic glucocorticoids. http://www.uptodate.com/home. Accessed Nov. 9, 2015. Wright MJ, et cetera. Genetic makeup, clinical features as well as diagnosis of Marfan disorder as well as similar ailments. http://www.uptodate.com/home. Accessed Nov. 9, 2015. MacGregor JL, et al.
Opportunities are actually, the majority of girls you understand possess. Chrissy Teigen does, and so performs Ashley Graham it is actually exceptionally usual, and there is actually nothing wrong along with your physical body or skin if you possess them, too. If you are actually much less keen on these little series, you may reduce their look (though scientific research has actually determined you can not remove them for great since but) (How To Get Rid Of Light Colored Stretch Markss).
What observes is our resource to all of the above."Stretch marks are actually brought on by fast extending of the skin layer throughout times of brisk body weight increase, maternity, or growth," clarifies Joshua Zeichner, supervisor of cosmetic and professional research in skin care at Mount Sinai Health Center in Nyc Urban Area. "The skin stretches so swiftly that the bovine collagen and flexible tissue are actually ruined, bring about the symbolic line-like look of the skin." You may possess also heard stretch smudges referred to as by their specialized name, striae.


text:
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To Our Valued Communities:
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On May 20, 2020, Governor Jay Inslee issued an updated proclamation about safely expanding non-urgent medical procedures and services. Based on the guidance in the proclamation, hospitals and health care organizations may now provide a full range of care – emergency, urgent, elective and routine – as long as PPE and surge capacity requirements are met.
I am pleased to share that MultiCare meets, and will continue to meet, those requirements. We are actively working to reschedule postponed surgeries, procedures and tests, and are also encouraging patients to contact us with new health concerns and for preventive care. Since many MultiCare providers are now performing virtual visits, you may be able to be seen by your own provider without needing to come into the clinic.
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About The Author
David Carlson, DO, is MultiCare's Senior Vice President, Provider Enterprises & Chief Physician Officer. More stories by this author

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Arduino Forum
Forum 2005-2010 (read only)
Software PWM using daisy chained 74HC595s / SPI
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Topic: Software PWM using daisy chained 74HC595s / SPI
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Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 12:41 am
Last Edit
: Oct 05, 2010, 01:26 am by tmartins
: 1
Sorry for multiple posts. Here are some usefull links:
How to make a current limiting circuit I mentionded earlier. Tested and works!
Cheapest 3w RGB leds you can find:
Nice stuff about BAM:
Other problems:
How an earth to get a tight beam from a rgb led with good color mixing. Lenses show the colors separate. Maybe a reflector with a bit wider base? Dunno....
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 04:53 pm
@Tomppu - nice updates - thanks for contributing improvements.
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 05:48 pm
Honestly, I think it's easier and nearly as cheap to drive power LEDs with dedicated ICs. There are many out there on the market, like the STP04CM05 I mentioned earlier. I got those for $2.20 a pop from Mouser. There are also single-channel drivers with PWM input that you can run from the TI PWM chips like the TLC5940, which you can combine for hardware PWM control (3000+ levels). I like the STP04CM05 with software PWM because it minimizes the PCB size and BOM.
If you are using the TLC5940, you don't want to drive LEDs directly with it, but instead control a constant-current IC or a transistor (you may find a hex inverter IC useful in that case since 'on' is LOW on the TLC).
I'm actually using the DealExtreme LEDs in our projects. They have good consistency and you can't beat the price. The are very sensitive to overcurrent situations though.
As far as beam concentration, I recommend a reflector over a lens for most uses. As you have found, the collimating lenses essentially project a huge image of the LED pads onto your target surface. Personally, I like the
SO27XA reflector
but I'm not sure about it's availability outside of the States. A diffusing material can help as well; frosted window film is cheap and works quite nicely.
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 06:21 pm
Last Edit
: Oct 05, 2010, 07:13 pm by PostOfficeBuddy
: 1
Tomppu, the thread you linked to actually contains the explanation and the solution to the flickering problem you encountered. Start at
this post
to see what I mean. The solution is to output the BAM waveform followed by a mirror image of it.
I don't have time to modify the code right now, but I might later this week. If you can get a working version using MIBAM (mirror image bit-angle modulation) I would be glad to test it!
Edit: There is a dedicated MIBAM thread
. After reading through, on the Atmega328 at 16MHz, I think it is possible to drive 64 channels at 120Hz with 11-bit resolution (2048 levels). At 10-bits you could drive 128 channels, etc. Then again that is based on assembly performance so I'm not sure what the difference would be using the Arduino IDE. But it's encouraging!
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 08:29 pm
I saw the mirror thing and I tried it but it did not seem to solve the problem. And is a bit the same thing done differently. The problem are the "long" bits 6, 7 and anything that splits them to pieces (mirror = each of the bits in two time slices.
Assembly would help but at least for me it makes the code slow to write and difficult to understand so I try to avoid it.
I am building a mood/disco light with 16 RGB=48 channels and the BAM seems to solve that.
Lets keep the thread open and post when ever new links or info comes or somebody gets new code working!
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 09:01 pm
@PostOfficeBuddy - thanks for your input.
STP04CM05 seems like a smart choice if you combine with sofware PWM/BAM. The current range of <400ma seems to fit many high power rgb leds. Digikey was $2.5 apiece and you need one per led.
The TLC5940 is not really that useful - $4,5 for hardware PWM and 16 channels, but it does not help driving the leds due to power constraints. 120ma per channel but not at all once.
I kind of liked the software + shift registers due to the cheap price and part availability for hobbyists. But this does not yet drive the leds and still needs a transistor / FET circuit.
Can somebody figure out how to make a working current limiting circuit with cheap PNPs that can handle <400ma. That would make a simple cheap driving system.
A lot of different choices as we can see and not one single best way to do things.
Part count and pcb area is also one constraint / design driver.
What we would like is probably the cheapest, easiest to build, easiest to control led driver solution for 10-100 leds.
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 05, 2010, 09:48 pm
Last Edit
: Oct 05, 2010, 09:50 pm by PostOfficeBuddy
: 1
Right, with the TCL5940 you still need power handling. It's only good for hardware PWM. The simplest true constant-current circuits (without an IC) that I've found are these:
- http://www.instructables.com/id/Power-LED-s---simplest-light-with-constant-current/
- http://www.instructables.com/id/Circuits-for-using-High-Power-LED-s/
But like I said there are many suitable ICs for the task that are not that expensive. Linear drivers are less efficient but reduce the board space and necessary components. You just have to pay more attention to heat and voltage requirements. Switching drivers have a larger BOM but are much more efficient and flexible.
The STP04CM05 is a linear regulator and you actually don't need one per LED. You need 3 per 4 LEDs.
Since they have 4 channels a piece. The only hardware I've had to use in addition was a simple PI (L/C) filter and a heavy-duty 25A protection diode which also lowers my 5V supply down to 3.55V. That has a large heatsink.
Also try Mouser for the driver ICs like STP04CM05, I've found they are significantly cheaper there.
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 07, 2010, 01:43 am
Mr PostOfficeBuddy. Thank you for your input. After sleeping over it would like to make a summary of what I have learned about driving leds with Arduino:
I think your idea of using the 400+mA 4 ch
http:// http://fi.mouser.com/Search/Refine.aspx?Keyword=STP04CM05
is the the best compromise in all respects if you want to make led room lighting with many channels. Want more light? put the leds in series (no common anode/cathode RGB leds then). Needs soft PWM/BAM, interrupts etc.
For something really huge (10-50A!) the 595 shift register mosfet solution might be the way to go. The mosfet FQP50N06L is $1 per channel so the price is really there. Not too bad, but that results in quite a big board if you go through hole. With surface mount components/board it would work ok. Needs soft PWM/BAM, interrupts etc. The current is defined by a 0.5-X Ohm resistor and you need one per channel so you cannot easily alter the current.
Dont like software PWM/BAM? Use TLC5940/TLC5947/MAX stuff, really easy to use with Arduino. Use the FET circuit we talked about for driving or if you do not have that many channels constant current sources might work for you and still keep your budget.
You like led cubes and matrices (low power stuff)? The Lightuino 3.0 Arduino Led driver with 70 sinks and 16 sources will drive your 1000+ leds and if you need more you can stack them. http://makersmarket.com/products/lightuino-led-driver-30-superstackable. Out of stock but they just sent me one for $60 or so. Just connect the leds and you are ready to go.
How to power everything? For low power and/or high voltage (=some leds in series) normal 9-24V power sources are cheap enough and give you enough current.
For low voltage (=5V) and high power you can use FlexATX computer power supplies like HEC-120SA-7FX that are small and cheap and will give you a lot of regulated current with 5V and 12V.
Please correct me if I am wrong or you get new ideas!
Best Regards,
ps PostOfficeBuddy - it would be nice to learn more about your (and other's) projects as I can see you have spent a lot of time working with these things.
ps2 One more thought about power losses. People seem to pay a lot of attention to power losses when driving these led things. I think this is illogical as long as we are not doing office lighting or 1000 street lights. I have maybe 500W of light bulbs lighting the house so 10+W of heat from my led mood lights is not really a problem or is it
And I do not even want to think about the new graphic cards for gamers.
Re: Software PWM using daisy chained 74HC595s / SPI
Oct 08, 2010, 02:20 am
Last Edit
: Oct 08, 2010, 02:23 am by tmartins
: 1
One more nice link. 38 a page document from ST micro.
"Generating multicolor light using RGB LEDs" (using a microcontroller, soft PWM and STP04CM05 4 channel driver)
Re: Software PWM using daisy chained 74HC595s / SPI
Jan 23, 2011, 11:17 am
thanks for a good sources.
I try to adapt your code for LED cube 3x3x3. In the code there are comments about the multiplex, I need this, but I do not understand how to do it correctly. Layers of the cube (cathodes) must be LOW for small intervals of time, but so that the PWM continued to work.As I understand it, it is necessary for the time TIMER_DELAY run through all layers and turn they to LOW then HIGH.
Please, tell me how to include it in your code right. Maybe the second timer?
And yet, once I started to ask))) I want to do frame animation with array with the LEDs status for each layer or column, like this:
{B01110000, b00001111},
Can you advise how best to use your code for this?
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Hytrin (Generic)
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This medication relaxes and dilates (expands) blood vessels resulting in lowered blood pressure. It is used to treat hypertension (high blood pressure). In males, this drug is used for symptoms of prostate enlargement such as urinary hesitancy and/or urgency.
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Tell your doctor your medical history, especially of liver disease, kidney disease, allergies (especially drug allergies). To avoid dizziness or fainting, get up slowly from a lying or seated position (especially when you first start using this drug or if your doctor changes your dosing). Limit your intake of alcohol and avoid getting overheated because they may increase the dizziness and drowsiness effects of this drug. Use caution performing tasks requiring alertness such as driving or using machinery. This medication should be used only when clearly needed during pregnancy. Consult with your doctor before breast-feeding.
Drug interactions
Missed dose
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Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.


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This was well written and I kind of have to ask
Did this happen to you? Its hard to tell over text if such a thing did or didn't and it does affect the impact of the reading some,well might just be me.
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Dear future/ up and coming podcasters, creating a podcast for free is possible, which is why I am going to take you on a step by step guide to starting your first podcast for free.
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Pick a title for your show
Because there is not much of an algorithm or much optimization that can be done to help your podcast be discovered or recommended, you should pick a title for your podcast that includes the keywords that represent your niche.
Try to come with something unique and creative and makes sure that it clearly communicates the niche or theme of your podcast to people who are searching for podcast shows or episodes that are related to your podcast's niche.
After that, we have have reached a crossroads. We have a very simple way of starting a podcast for free, and a more complicated method of doing so.
How to create a podcast for free using nothing the easy way?
Let us start by discussing how you make a podcast with your smartphone. What I am about to share with you is the easiest way to create a podcast for free.
How to create a podcast for free using your iPhone or Android?
Many professional podcasters use their smartphones as a part of their podcasting setup, but for people who have a total budget of zero dollars, can they actually manage to turn their smartphones into their entire podcasting setup?
Yes, they can! Creating a podcast for free has never been easier thanks to an application called Anchor FM. The creators of this application already claim that Anchor FM is the easiest method for podcasters to make podcasts, and I agree. Not only is it easy to use, but it is also FREE!!
However, I am not going to end this post by telling you that you can record, edit, and publish your podcast for free using this application. Instead, I am going to take you on a step by step guide and show you screenshots of me doing everything that you need to do to have a published podcast.
Everyone, take a deep breath because this fantastic application is free to download for both iPhone and Android, so literally, anyone with a smartphone will benefit from this step by step guide to making a podcast for free.
Without any further ado, let us start creating our podcasts using the Anchor App. First things first, I am going to the Apple store to download the Anchor application.
Kindly note that this blog post is not sponsored in any way, shape, or form by Anchor.
Now, I would not recommend using Anchor forever, but it is an excellent way for new creators to get into the waters of the glamorous world of podcasting. So while the app is installing, let us briefly discuss what the Anchor application is similar to. By the way, the application has a website as well.
The Anchor application/ website is a podcasting platform and distributer that can be easily compared to YouTube, but for audio content/ podcasts. They are both free, and they both handle a lot of technical things for you, so the interface is not complicated for content creators and content consumers.
When the Anchor application is downloaded, let open the application and begin exploring Anchor FM. At the end of this step by step guide to creating a podcast using Anchor, I will be answering three crucial questions.
These questions are the following:
- Does it do what it claims to do; aka, allows us to record, edit, and publish our podcasts?
- Is the App easy to use?
- Is it efficient?
Now, let us talk about creating your Anchor account.
How to create an account on Anchor for your podcast?
There are only two methods for you to sign up on Anchor, which via signing up with your email or by using your Facebook account.
I have personally decided to sign up using my email, but feel free to do whatever you want. To sign up for an Anchor account, all I needed was to type in my name, email address, and password to able to explore the application.
I got redirected to this page on the App that offered me four different options to answer the question of what brings me to Anchor.
These four potentials answers are the following:
- Because I want to make a new podcast
- Because I want to learn more about podcasting ( which you can always check out from further guidance)
- Because I am moving my already created podcast to Anchor
- Because I want to listen to podcasts
Since we downloaded the application to be able to create a podcast for free, I have clicked on the firs, red button.
Next, a message will pop up asking whether or not we are interested in receiving notifications from Anchor.
I personally said no because I no longer allow ninety-nine percent of the apps on my phone to send me notifications, but feel free to do whatever you like.
Now that we've responded to that pop-up message, we will be redirected to a page that is still on the app, where Anchor is going to share with you four simple podcasting tips to help create your podcast via this application.
Anchor's podcasting steps and tips
The first step or tip is all about recording or importing your episode's audio. Since we are using Anchor to do everything, this means that we are going to do that on the app itself.
However, it is good that people who record their episodes on other applications can actually import their episodes into Anchor and still be able to use it.
The second step or tip shows us that we can make an episode by building it up using multiple different segments. This means that you can easily record your episode part by part; you do not have to record the entire audio at once.
Each segment can record up to an entire hour's worth of audio content, so if you are creating episodes that are longer than one hour, do not worry. You will just have to record your episode by recording two different segments and add them to your to be uploaded episode in the correct order.
The third step or tip is telling us that we can distribute our podcast everywhere with just one click. However, when we actually reach that step, we won't press on that button. We'll just manually submit our podcasts to the popular podcasting platforms ourselves.
So we could access our podcast's analytics on each one of these podcasting platforms. If you let Anchor do that for you, you won't be able to access your podcast's analytics on Apple Podcasts, Spotify, etc.
The mini-episode I am going to record is only going to be Anchor though ( I won't manually distribute it) because this is just me testing the application.
However, when I actually launch my podcast, I will make sure to take all of the important screenshots and make more step-by-step blog posts on that.
The fourth step or tip is publishing our podcasts and waiting for our audience to find our podcasts and listen to them.
Now that we have a clear idea regarding how we can create our podcasts on Anchor, let us start recording that our first episode.
Of course, you have first to do some research and outline your episode. I am going to assume that you already know what you are going to talk about in this episode, or you can create an experimental episode just like yours truly.
How to record audio on Anchor?
Like we have mentioned before, an episode is made of multiple segments, so let us start by recording a segment. You can do that by tapping the plus sign in the purple circle that is above the word "Tools".
Now, let us record a segment. To do so, just click on the plus sign in the purple circle. Next, press on that red, recording button and start talking.
Once you finish recording your segment, click on the X in the red circle to end the recording.
Press the big play button to listen to your audio recording. If you really hate it, you can delete your segment and record another one.
If they're just a few things that you would like to change, you can just stick to editing it, which comes later on. So if you like the segment, but you think it needs some editing, click on the Save button.
Name your segment and click on the "Add recording to episode" button. You will be asked whether ready to publish this episode or not. Since we still want to edit our segments, we will press on not yet.
Make sure that your segment is fully uploaded. Next, we'll start editing our recorded audio!
How to edit a podcast episode on Anchor?
Now that our segments are fully uploaded, we are going to click on the three dots next to the uploaded segment. We are going to get a few options to pick from when we click on theses three dots. We have segment options like adding background music, renaming the segment, or deleting it from our episode.
We also have editing options like trimming our segments' start and endpoints and editing our audio.
I personally first started by trimming the silence that existed at the beginning of my segment and deleted a sentence from the end of the segment. Here is how doing that looked like.
When you click on Trim start/ endpoints, this is what you are going to see.
The picture above is my untouched, recorded segment. The picture below showcases that I am removing the silence that exists at the beginning of my segment.
Next, I pressed on the save button and moved on to editing my segment. This means that I clicked again on the three dots and clicked on edit audio this time around.
Anchor's editing program basically works by allowing us to split our audio and save all of the split segments. Then, we can remove the unwanted segments by deleting them from the dashboard. It is very basic and simple, but it is going to get the job done.
As you can see, the image that I have up above, this is what my episode looks like. Now, do not worry about me having three separate segments. Since all my segments are in the same episode, Anchor will sync and play them as if they are a single audio file.
Now that we've finally edited our first podcast episode, let us move on to setting up our podcast and creating our podcast's cover art.
How to setup up my podcast on Anchor?
There are a few things that we have to do every time we record and edit and new episode, and that is typing in the episode's title and description.
We can also customize a specific image for our episode, which I have done here, but I don't recommend doing it. We can insert the season and episode number, which is also optional and not required.
The photo on the right is what my dashboard looked like at the end. But don't worry, because I will still be taking you through the remaining steps.
Click on publish now and type in your podcast's description. Try to include keywords that are related to your niche, then click on use this description.
Next, add some tags that describe what the podcast is about, and add tags that include keywords that are related to your niche and your episode, then click on done.
Up next is working on the cover art. So, I searched for an image and played and added the podcast's title on it in the font Karla and clicked on continue.
Now that we are finally done setting up our podcasts, Anchor is going to suggest to us that we distribute our podcast on the major podcasting platforms. Avoid clicking on the Great, thanks button, and instead, go for the I'd rather do that myself.
PS: The image on the right is an overview of the episode that I have just published.
The last thing that we are going to do is disable two options that Anchor automatically enables for your podcast. We will do that by going to podcast settings and turning off the Anchor logo on cover art and the Anchor post-roll in episodes.
By doing so, we are ensuring that there won't be any Anchor related Ads being played to your audience, and there won't be an Anchor watermark on your podcast's cover art.
If you are interested in listening to my experimental mini-episode that is edited and published on Anchor, then all you have to do is click here!
Now, do you remember the three questions I mentioned at the beginning of this blog post?
- Does it do what it claims to do; aka, allows us to record, edit, and publish our podcasts?
- Is the App easy to use?
- Is it efficient?
From what I have experienced so far while using the Anchor app so far, the answer is yes to all of these questions.
What makes this podcasting application truly shine is how simple and easy it is to use. Oh, and the fact that it is totally free.
If you are interested in testing the waters of the glamorous world of podcasting, then I believe that using Anchor is truly the way to go. Once you get the hang of it, though, I would recommend that you move on to something more prominent and paying for your podcast hosting site.
How to create a podcast for free by taking the higher road?
Now that we have discussed how you can easily create a podcast for free, let us talk about how we can create a free podcast the harder way, aka, without the Anchor application.
Step one: Recording and editing
Since we are not relying on the anchor application, we are going to need an application or software to record and edit our episodes.
Depending on what sort of devices you have, you can pick your recording and editing software.
- BandLab to record and edit our podcasts on Android phones.
- GarageBand to record and edit our podcasts on iPhones, iPads, or MacBooks.
- Spreaker Studio to record and edit our podcast on Windows, Mac, iOS, or Androids.
- Audacity to record and edit our podcast on laptops or MacBooks.
Step two: Getting a podcast hosting service
There are three great hosting platforms that offer you free memberships. These three sites are the following:
- Podbean
- Buzzsprout
- Soundcloud
If you need help with choosing the perfect podcast hosting site for you, then feel free to check out my recommendations for the best podcast hosting sites.
Of course, since you are using a free membership, you won't have access to a lot of features, but at least you will have an RSS URL feed that you can use to distribute your podcast onto different podcasting platforms.
However, it is going to be super easy for you to just upgrade for a better and a paid tier when your podcast starts growing or when you are ready to spend a bit of money on your podcast.
Here is what you get from each of these hosting platform's free subscriptions:
When you subscribe to PodBean's free plan, you are going to have the ability to upload five hours ( 5 hrs) of content every month. You are given a bandwidth of one hundred GB ( 100 GB) every month
You will also get access to basic statistics regarding the performance of your podcast.
When you subscribe to Bussprout's free plan, you are going to have the ability to upload two hours ( 2 hrs) of content every month, have access to the entire podcasting dashboard, but your storage duration per episode lasts for only ninety days (90 days).
When you subscribe to Soundcloud's free plan, which is the SoundCloud Basic Plan, you are going to have the ability to upload three hours ( 3 hrs) of content every month, have access to basic statistics, and embedding options.
Get your podcast on multiple podcasting platforms
The more podcasting platforms your podcast is own, the higher your chances of getting discovered and listened to. However, you should at least have your podcast on Apple Podcasts, Spotify, and Pandora.
If you do not know how to do this, do not worry! I have three short posts that guide you when you are submitting your podcast to these podcasting platforms.
To get your podcast on Apple Podcasts, read my How to Publish A Podcast on Apple Podcasts blog posts.
To get your podcast on Spotify, check out my How to Publish A Podcast on Spotify blog post.
To get your podcast on Pandora, read my How to Submit Your Podcast to Pandora: A Step-by-Step Guide blog post.
If you can get your podcast on Google Podcasts, that would be amazing! To learn more about Google Podcast, make sure that you check out my Can My Podcast Appear in Google's Search Results?
How to Submit Your Podcast to Pandora?
To get your podcast on Pandora, go to Pandora AMP, and register for a new account or log in. Next, make sure that you meet their requirements like having cover art that is 3000 x 3000 pixels in .png or .jpeg, and that is original and is not explicit. Now, insert your podcast's RSS feed.
For a step-by-step guide on how to submit your podcast to Pandora, make sure that you read my How to Submit Your Podcast to Pandora: A Step-by-Step Guide blog post.
What are the requirements needed to submit a podcast to Apple Podcasts?
Two major requirements include are:
- Go to your podcast's hosting site and get its RSS URL feed link.
- Making sure that your podcast's cover photo is at least 1600 x 1600 pixels, but at most 3000 x 3000 pixels.
You can learn about all of the requirements you need to meet before you submit your podcast to by reading my How to Publish A Podcast on Apple Podcasts blog post.
How to Grow Your Podcast Audience?
Five things that you can do to grow your podcast's audience are the following:
- Appealing to your Audience
- Asking your listeners to rate your podcast and leave honest reviews
- Improving the quality of your podcast
- Utilizing the features that the podcast hosting site provides you
- Using Pat Flynn's Ninja podcast marketing strategy
To learn about how you can grow your podcast's audience, read my How to Grow Your Podcast Audience blog post.
That's it for today's post. You should now be able to start your podcast for free.
There are also so many free methods that you can use to improve the quality of your content, promote your podcast and grow your audience, so make sure that you browse this site for these resources and check out my sources.
My Sources
- How Much Does It Cost to Produce A Podcast?
- How to Choose the Best Podcast Hosting Site?
- How to Grow Your Podcast Audience?
- 11 Steps For Attracting New Podcast Listeners
- 6 Simple Ways to Grow Your Podcast Audience
Till next time,


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After a long day at school, most children come home hungry, tired and ready to do anything but more school work!
Here are Families Wokingham Woodley's top tips to surviving the homework battle.
Let you child come home and relax, play, or chat – whatever they need to do to unwind from their day at school.
Give them a snack but try to avoid sugary snacks as this could be followed by a slump once the effects have worn off. Aim for fruit or crackers with cheese, or hummus and vegetable sticks.
Establish an 'area' where homework will always be done. This needs to be away from the distractions of other siblings, the TV, or anything that will draw their attention away.
At the start of the academic year, make sure they have all the supplies they will need for homework at home, as well as all the things they need for their pencil case at school.
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Try – if you can – to sit with your child if they need your help. Not always easy with jobs to do and other children to attend to but with an established routine it might be more manageable.
Remind your child of that important word – YET! Get them used to finishing the sentence "I can't do it" with "yet".
Encourage, motivate and reward your child for completing their homework! Often an extra ten minutes before bed time to read with you does the trick!
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text: OurOntario searchWelcome to the OurOntario Discovery Portal, a service of Knowledge Ontario. http://search.ourontario.ca/atom Knowledge Ontariohttp://search.ourontario.ca/atomtile_50x50.gif120 Bi-Centennial Wall Hanging from FWIO <img src="http://images.ourontario.ca/Partners/FWIO/FWIO003602173t.jpg" alt=" Bi-Centennial Wall Hanging from FWIO " /> This wall hanging was presented by the Federated Women's Institutes of Ontario to the Province of Ontario for the province's bi-centennial on June 11, 1984. It is on display at the Legislature, Queen's Park, Toronto. This image was taken from an FWIO hasti-note package. This wall... http://collections.fwio.on.ca/3602173/data2019-09-05T13:43:06.381Z


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Photo from Chen Jiangang Twitter
BEIJING, China – A Chinese human rights lawyer said Sunday, August 4, he had landed in the United States despite being stopped from leaving Beijing in April by mainland authorities who imposed an exit ban on him.
"My family and I have landed in JFK airport, New York, late night on August 3, 2019," Chen Jiangang said in a statement provided by a friend to Agence France-Presse.
In April, the lawyer was pulled aside by customs at Beijing Capital airport as he prepared to board a flight to Seattle and told he was banned from leaving China.
He had been selected to study English there as part of the Hubert H Humphrey Fellowship, a program named for the late vice president that provides a year of US education for emerging leaders from around the world.
Beijing defended the ban as "in accordance with China's own laws," but the US State Department called it disturbing.
It was Chen's work as a human rights lawyer in China that landed him in authorities crosshairs.
Chen represented Xie Yang – a leading lawyer involved in politically sensitive cases including defending Hong Kong pro-democracy activists – who was himself rounded up in a sweeping crackdown on legal staff in 2015.
Chen remained vocal on the case even after authorities removed him as Xie's lawyer, drawing attention to his former client's allegations of torture in police custody.
In a separate 2017 incident criticized by the United Nations human rights office, Chen was stopped while vacationing with his family in remote Yunnan province.
His wife and young children were allowed to fly back to Beijing, but Chen said he was taken back via a 3,200-kilometer (2,000-mile) road journey under police escort.
"Merely for following and defending the law in normal practice, I have met naked threats delivered in my face by officials representing the Chinese government," Chen said in Sunday's statement.
"Such threats have put me in imminent danger of enforced disappearance, torture, or even death."
Chen did not say how he came to leave China, but thanked friends and human rights organizations for their "rescue work and help."
"Without them, our family would not have made it to freedom," he said. – Rappler.com


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PUMA Men's Limited Edition X P Golf Hat
Size: One Size
Product Information
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Immuno 101
"Immunotherapy is a penicillin moment in the history of cancer treatment, we are now seeing the word cure and immunotherapy in the same sentence for the first time."
Patient Tool Kit
Clinical Trial Research
What are they?
Checkpoint inhibitors
T Cells have these on their surface CTLA 4 & PD-1 are the primary examples. Their job is to interact with the cell surface before the attack begins. If the attack is a mistake on a healthy cell they "down regulate" /switch off the attack – like a fail safe switch.
Example: PD-1 the inhibitor sits on the T Cells surface, its job is to bind with any PD-L1 present on a cells surface (See image below). This is binding communication is friendly indicating a healthy cell and the attack is ceased. PD-L1's are ligands (elongated proteins) that embed themselves into the cells surface and act to stop a T Cell act by binding with the PD-1.
Mutated Cancer cells have learnt to exploit and hide by expressing PD-L1 on its surface.
Checkpoint Inhibitor Immunotherapy drugs interfere with the T Cells PD-1 inhibitor switch by blocking its function and ability to turn of a T Cell attack.
Check Point Inhibitor Immunotherapy allows our own Immune System to do its job and destroy the previously unseen cancer threat.
It is thought that High Mutation Tumours (TMB -high) express higher levels of PD-L1 ligand proteins and thus exploit this to their advantage.
Currently successful Check Point Inhibitor drugs
Keytruda and Odivo's Nivolumab block the PD-1 from binding to PD-L1. Opdivo also has Ipilimumab a drug developed to block CTLA-4 Nivo and Ipi are often used /combined into one treatment.
Other important factors in the success of this therapy are detailed in other chapters "MMR /dMMR" "MSI-High" "PD-1/PD-L1″ TMB"
There is also another new and exciting /emerging immunotherapy called "CAR T Cell"
The Immune systems basic process
- Identify – APC (Antigen Presenting Cells) are the immune system messengers. Their job is to seek out cancers, grab a piece of the suspicious cell, and deliver it back to the T Cells. This excites the T Cells.
- Activate – CTLA-4 (Check Point Protein) sits on the T Cells surface. Its job is to activate – Switch ON a T Cell attack based on the APC's findings.
- Infiltrate – PD-1: (Programmed Death 1) Another Check Point Protein sits on the T Cells surface. Its job is to deactivate – Switch OFF a T Cell attack based on binding with a friendly PD-L1 on the surface of the suspicious cell, thus preventing healthy cells from being destroyed.
Our Immune System is very clever it has B Cells
It has an army of cells to remember encounters with threats – cells that remember our flu viruses also remember cancers.
Once a cancer is discovered, the B-Cell's swing into action by searching within its ranks for one cell the can engage and learn this new threat. When one of the B Cell's learn the DNA finger print of this new threat, it begins to replicate itself into the thousand who now know this cancer.
The B Cell replication creates 2 types of new B-Cells
- 'Memory B cells' that remember the cancer
- 'Effector B cells.' These Effector B-Cells – antibody factories that produce millions more B-Cell antibodies should the cancer ever return.
This is the huge upside to Check Point Inhibitors that not only keeps the T Cell's attack switch in the ON position, but it also allows the B Cells to remember, thus one the immunotherapy is ceased after 2 years the B Cells will take over from there.
The image above shows a tumour cell expressing a PD-L1 ligand and attempting to bind with the T Cells, PD-1 (Check Point Protein) A successful binding will result in the PD-1 switching off the T Cell attack. The image also shows the presence of the "Checkpoint inhibitor drug" Keytruda intercepting and blocking this binding /connection.
What are Immune Response T Cells
T Cells are relentless and very efficient killing machines.
But they need to see the threat.
When the immune system activates its T Cell army against a new threat, the activated T Cells express a check point protein called PD-1 onto their surface
What are PD-1's
PD-1 is an Immune inhibitory checkpoint molecule that is expressed by an "Activated" T Cell. The PD-1 function is to bind and communicate with PDL-1 receptors that sit on the surface of healthy cells. When PD-1 successfully binds with a PD-L1 ligand protein, it then transmits an inhibitory signal back to the T Cell to cease the attack.
What is PD-L1
PD-L1 Ligand is an elongated cluster protein that a cell expresses. PD-L1 ligands attach themselves to the membrane surface of a healthy cell. It's function is to act as an immune regulatory molecule (A Check Point Molecule) that protects healthy cells form being attacked by T Cells.
The immune System has Check Points
Our immune system is essentially in a permanent attack mode and has inbuilt check points (PD-1) to switch off attacks when encountering healthy Cells. Tumours have learnt to exploit this by expressing the PD-L1 ligand on their cell surface.
Microsatellite Instability (MSI)
Word terms
- Microsatellites are parcels of DNA code
- Microsatillite Instability in those parcels (MSI)
- Mismatch Repair (MMR) our body's dna spell checker
- Deficient Mismatch repair (dMMR) means failure of the spell checker
Microsatellite Instability occurs when the strings of dna contained within the microsatillites, replicate incorrectly creating errors in our dna code.
MSI is described as follows
- MSI-high: (MSI-H) occurs if two or more microsatellite markers show instability
- MSI-low: (MSI-L) occurs if there is only one marker unstable
- MSI-Stable : (MSS) results when all the five microsatellite markers are stable
Reporting often describes MSI as follows
- MSI-h > 30%
- MSS – 0% instability
MMR the Spell Checker
- MMR – means all genes are functioning / expressing correctly
- dMMR – when one or more genes are not expressing and correctly
There are 4 primary MMR genes are MLH1, MSH2, MSH6, and PMS2
Think of these genes as our body's spell checkers, their job is to express proteins that fix / repair DNA replication errors as they occur. This is a normal function within our body.
What is it spell checking?
- Errors occur often in our DNA replication process.
- Microsatellites are parcels that contain strings of our pre-made dna code – the code that makes us – us!
- This replication process is constant and errors are normal
- When all 4 MMR genes are expressing proteins (spell checkers), then this is described as MMS (Stable).
When one or more of theses genes fail to express their proteins (spell checkers) this means the MMR process is now deficient and is not correcting all DNA mistakes as they occur. This then leads to accumulation of dna replication errors within the microsatillites creating microsatillite instabliity.
Uncorrected errors lead to accumulations of defective cells that cluster and can form cancer mutations.
Immnuotherapy and MSi-High
The MSi-high status has so far proven to perform best with Checkpoint Inhibitor Immunotherapy treatments, so this is the primary testing objective.
Testing for MSi-high
There are 2 primary testing methods to determine this, both require a tissue sample (biopsy)
- IHC fast efficient and inexpensive
- Molecular profiling more expensive and slower
- Blood Profiling – Still in early stage
IHC and Molecular test accuracies a 92% and 95% with bloods much lower at this stage (2019)
For the purpose of discovering if you are a match for Check Point Immunotherapy, the IHC test is most logical. If via the IHC test you do not have the MSi-high as a biomarker then pursue the full "Molecular Profiling" to discover a full road map of you tumors make up and what mutations are driving your cancer. This can then be matched up with known treatments globally.
Digging a little deeper
IHC Test Description
Immunohistochemistry Test – fast and Efficient (3 -5 days) see Testing Page
What you testing for is MSi-high result, as immunotherapy responds well to this.
What do Microsatellites do?
They are the containers that hold our repetitive sequences of nucleotides (DNA code).
What are Nucleotides?
- Nucleotides are sequences of our DNA code. (Sequence repeats)
- Nucleotides are our "DNA Building Blocks"
- Nucleotides typically have 2 to 7 different types of pre programmed sequences of repeat code –
- Each sequence can contain between 2 -25 characters (string or stretch of code) – see diagram below.
- Nucleotide sequences continually replicate.
- Everyone has different pre programmed sequences.There can be hundreds of different code sequences.
The Nucleotide replication process can often go wrong
The MMR expressed proteins corrects these spontaneous errors as they occur. When our MMR spell Checker is compromised or weakened then inconsistencies in the Microsatellites Nucleotides repeats over and over, this is when cancers can form.
Lab testing (IHC) can easily discover this when comparing a healthy cells numbers or sequence, with cancer cells. If a difference is identified, then this is referred to as "microsatellite instability".
MSI levels/identification
Microsatellite Markers
Samples of Nucleotide code sequences contained within a microsatellite, these are supposed to replicate exactly the same in tandem.
Scott Paulson MD
Extract from CURE who spoke with Scott Paulson, M.D. medical oncologist with Texas Oncology, an affiliate of The US Oncology Network, to break down exactly what MSI-H status is, and the effects it may have on certain malignancies. Full Article link
MSI-high tumours form a well defined group with distinct clinicopathologic features (more easily identifiable) which characterises an overall better long-term prognosis.
MSI-H is a feature of cancer's genetic coding, which results in it behaving and "looking" a certain way on a microscopic level. Due to defects in the way that DNA in the cancer cells repairs itself, it creates changes and mutations to normal body cells that can eventually let them turn into cancer. However, these cells become so abnormal, because of this feature, that the immune system, which is used to protecting the body against bacteria and viruses and other foreign invaders, can actually look at the cancer and recognize that something is very wrong. This can call the body's normal defenses against invaders to try to attack the cancer.
TMB is also a factor
Something to be aware of.
When the body has a dMMR/MSI-High environment it typically sees a higher TMB (tumour mutation burden) in the body and these tumours also have a strong correlation to higher expression of the protein ligand PD-L1 which anchors to the surface of the tumour cells.
Tumor Mutation Burden (TMB) refers to the total amount of cancer tissue in the body. The survival of a patient relates to the tumor mutation burden, disease location and most importantly, the pace of the disease. In general, patients with a high burden of tumors have a high pace of disease and therefore a very short survival without therapy.
More About TMB
Onclive 2018
Patients most likely to respond to immune checkpoint inhibitors (ICIs), tumor mutational burden (TMB) has emerged as a highly promising and clinically validated biomarker. Results from studies have demonstrated that subsets of patients with high TMB exist across almost all cancer types and that assessing TMB through whole-exome sequencing (WES) or next-generation sequencing (NGS) can predict response to a range of different types of immunotherapy.
TMB has been a hot topic at oncology conferences this year. Investigators and test developers must overcome a variety of challenges before it is ready for prime time as a biomarker, but it appears poised to bring immunotherapy into the era of personalized medicine.
A Heavy Load
It is a central tenet of cancer biology that tumors arise and evolve as a result of the acquisition of damage to the genome, generating characteristic genomic alterations that lead to the dysregulation of key cellular processes termed cancer hallmarks. In addition to identifying individual frequently altered genes that function as drivers of particular cancer types, results from genome sequencing studies have revealed the global spectrum of somatic mutations across a given tumor, known as the TMB or mutational load. TMB is defined as the number of mutations per megabase (Mb) of DNA.
Seeds of Their Own Destruction
It has long been suspected that cancers with a greater number of gene mutations may provoke a stronger antitumor immune response. The thinking behind this hypothesis relates to the production of neoantigens—fragments of proteins expressed on the surface of cancer cells that are encoded by mutated genes. Neoantigens are unique to cancer cells because they are derived from a mutant gene, which may encode a mutant protein that differs from that expressed by normal cells. Therefore, neoantigens have the potential to be recognized as foreign by the cells of the immune system that patrol the body. A greater number of neoantigens might mean increased stimulation of those immune cells and a stronger immune response. In this way, cancer cells may generate the seeds of their own destruction.
My Kingdom for a Biomarker
MSI and dMMR and are just 2 of the many phenotypes that can cause hypermutant tumors and contribute to high levels of TMB. If tumors with higher TMB provoke a stronger immune response, then it stands to reason that TMB could provide a means for more comprehensive assessment of patients who might respond to ICIs and potentially other immunotherapies. In the past several years, investigators have started to evaluate TMB in this capacity, and it has emerged as a powerful predictor of response to ICIs in a range of tumor types Investigators are seeking to correlate TMB with clinical and biological outcomes in a number of ongoing clinical trials.
High TMB
Tumor Mutational Burden (TMB) is an emerging, quantitative indicator for predicting response to novel immune checkpoint inhibitors across a wide spectrum of tumor types. TMB measures the total number of non-synonymous, somatic mutations identified per megabase of the genome coding area (a megabase is 1,000,000 DNA basepairs).
Tumors with high TMB likely harbor neoantigens and may respond more favorably to immune checkpoint inhibitors. Caris Molecular Intelligence defines TMB as 17 or more mutations per megabase. TMB is included for all MI Profile orders, at no additional cost, added tissue or delay in turnaround time.
How Tumor Mutational Burden Works
- Non-synonymous mutations are changes in DNA that result in amino acid changes in the protein.
- The new protein changes result in new shapes (neo-antigens) that are considered to be foreign to the immune system.
- Immune checkpoint inhibitors are able to stimulate and allow the immune system to detect these neoantigens and destroy the tumor.
- Germline (inherited) mutations are not included in TMB because the immune system has a higher likelihood of recognizing these alterations as normal.
A different approach, bypassing the Check Point Inhibitor.
What is the role of T-cells in the immune system?
T Cells are the immune systems soldiers who search out and destroy the foreign invaders, such as flu and cancer.
Chimeric antigen receptor CAR T Cell
- CAR T Cell Therapy is a way of engineering the bodies T Cells to recognise cancer, by reprogramming the bodies own T Cells to recognise and destroy the cancer.
- T Cells are removed from the patient and then the patients Tumour antigens are added to teach the T Cells.
- The newly modified T Cells are then grown into the millions and then reintroduced into the patients body.
- CAR T-cell therapy, is a new form of immunotherapy that uses specially altered T cells to directly and precisely target cancer cells.
The immune system is made up of a variety of cells and organs that normally protect the body from infection and cancer. An important component of the immune system are T cells, which have the capacity to hunt down and destroy abnormal cells, including some cancer cells.
Sometimes, cancer cells find ways to evade the immune system; so, the immune system needs to be retrained and enhanced to recognize and attack cancer cells. CAR T-cell therapy is one innovative approach to program and strengthen the immune system to attack some forms of cancer.
After a small portion of a patient's own T cells has been collected from the blood, these cells are re-engineered in a special laboratory so they now carry special structures called chimeric antigen receptors (CARs) on their surface.
When these CAR T cells are reinjected into the patient, they multiply rapidly and these engineered receptors may help the T cells to identify and attack cancer cells throughout the body.
CAR T-cell therapy has been shown to be effective in B-cell acute lymphoblastic leukaemia (ALL) and adult diffuse large B-cell lymphoma (DLBCL).
There are no approved CAR-T treatments worldwide for solid cancers. However, research is underway at Peter Mac in CAR-T cell treatment of solid cancers. Please see Clinical Trials.gov for further information.
Page Source https://www.petermac.org/car-t
Terminologies in Immuno 101
APC: Antigen Presenting Cells: The immunes messengers.
B Cells: learn the tumour or virus DNA to recognise if they return.
Biopsy: A tissue sample extracted from your tumor and used by a laboratory to discover Biomarkers.
CTLA-4: A Check Point protein that sits on the surface of the T Cells. They prevent mistake attacks on healthy cells.
Check Point Inhibitor– See PD-1 below
Car T Cells: An new innovating immunotherapy technique
IHC: Immunohistochestry Test for discovering PD-L1 and MSi status
Ligand: An elongated strand of protein receptor that anchors to a cells surface. (ie PD-L1 is a Ligand receptor)
Molecular Profiling: Provides a DNA road map of the tumours finger print (Genomic) and your hereditary finger print (Genetic)
Microsatellites: Microsatellites are stretches of DNA that contain a repetitive sequence of nucleotides
Nucleotides: Nucleotides are the repetitive strings of DNA code that make us – us. example of a code string; "AAAAA or CGCGCGCG" (codes are short tandem sequences that replicate)
MSI: is a measure of Microsatellite Instability
MSI-LOW: is a low recorded measure of Microsatellite Instability.
MSI-HIGH: is a high recorded measure of Microsatellite Instability.
MSS: is Microsatellite Stable, which means no instability is present
MMR: Mismatch Repair is the DNA repair pathway that plays a key role in maintaining our genomic stability. MMR is our "Spell Checker" correcting any errors in our DNA replication process as they occur. MMR is made up of 4 proteins (MLH1, MSH2, MSH6, & PMS2 )
dMMR: Deficient Mismatch Repair means that one or more of the 4 MMR proteins absent and as a result the MMR is not functioning correctly and is described as deficient
TMB: means Tumour Mutation Burden
PD-L1: means Programmed Death Ligand 1 – a cluster protein that generally coats and protects healthy cells from the immune systems T Cells
PD1: is an Immune Check Point Inhibitor – its function is to switch off a T Cell attack. It does by binding and communicating with the PD-L1 anchored to a cells surface.
PD1/ PD-L Pathway: A communication pathway / channel that dampens or deactivates (switches off) an immune response – (T Cell attack) on healthy cells.
Simple explanations and Video


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Author(s): Michael Bond
For more than five decades, stories of Paddington Bear have delighted children all over the world. The classic story of the bear from Darkest Peru who arrived at Paddington Station with nothing but a suitcase, a half-empty jar of marmalade and a label that read, 'Please look after this bear. Thank you.' Mr and Mrs Brown discovered him, named him Paddington and welcomed him to their home, where he has lived ever since.


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A place to enjoy an evening cocktail. This stunning Olive Green Leather chair by Eleonora is made from a sturdy metal base and upholstered in faux leather for superior comfort. This chair features casual shapes and touchable textures that create comfort and inspire easy conversation, with its roll-tufted back, smooth seat and comfortable side arms.
- W26 x D34 x H35in | Weight 41lbs
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FOLLOW UP BRIDAL APPOINTMENT – Luxury Room
Three guests permitted – due to large fitting area.
Say 'I do' in Dotty in style by returning to finalise your dream gown with us in our brand new Bridal suite. Celebrate in style with our Dotty cocktails menu, which will be availabe to purchase on the day.
Duration : 1 hour
Due to COVID-19 we are limiting the number of guests, therefore only the Bride and three guests are allowed at this time due to the new 1 metre distancing rules.
Virtually bring your Bridal party to the appointment with our exclusive facetiming facility.
*subject to change
Say 'I do' at Dotty and take home your complimentary 'Dotty Bride' mug and exclusive gifts.
*Please be aware your Card details will be taken at the point of booking your appointment. We have a £25 cancellation charge for appointments cancelled or missed within 24 hours of appointment time. You will receive text/email confirmations and reminders of all your booked appointments. If you do not, please contact us on 01484 950700


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Gwinn, Michigan– 02/18/16– Our Gwinn Girls stayed home this Thursday night to take on the Norway Knights! This game was the last home game for our seniors Tori Lauren and Nichole Usher and the coach had many wonderful things to say about working with these two talented women. Mike and Justin brought you all of the game coverage on Fox Sports Marquette 105.1 and 99.9. Also, the game was streamed LIVE at GoToGwinn.com.
The game started off really special for our ModelTowner senior, Tori Lauren. She had recently broke her thumb and was unable to play this game but the two coaches agreed that it would be nice if she was able to start off the game with the tip. It was such a lovely gesture for such a great player. The first two points of the game were made by a Knight. Nichole Usher fought back with a three pointer in the first quarter! Tiara Taylor made a shot by an assist from Nichole Usher and right before the second quarter, Nichole Usher made another three pointer. 12-12 was the score at the end of the first quarter. Tiara Taylor made more baskets for Gwinn in the second quarter to keep up the score when the Knights started to take the lead. 17-30 was the score at halftime with the Knights in the lead.
The second half of the game, the Knights started to gain a steady lead. Tiara Taylor was a force in this game for Gwinn and she kept up her energy to keep scoring those much needed points. 23-29 was the score at the end of three with the ModelTowners trailing. Kia Evans scored in the fourth quarter for Gwinn and so did Anna Cole! 37-53 was the final score of the game with the Knights taking a win over our ModelTowner ladies. The coach was feeling good about how the game turned out without Tori Lauren and he made it clear that he will miss his seniors and that he is very proud of them. Mike and Justin brought you all of the in-game action on Fox Sports Marquette 105.1 and 99.9. Also, the games are always streamed LIVE at GoToGwinn.com.
Final Score: ModelTowners 37, Knights 53
Brenna Bruce: 2 points
Trish McGuire: 2 points, 2 rebounds
Nichole Usher: 9 points, 6 rebounds, 1 foul
Anna Cole: 3 points, 4 rebounds, 1 foul
Kia Evans: 4 points, 3 rebounds
Tiara Taylor: 6 points, 5 rebounds, 3 fouls
Taylor Innis: 1 point, 2 rebounds, 1 foul
LISTEN FULL GAME- Gwinn ModelTowner Girls basketball was defeated by the Norway Knights on Fox Sports Marquette 105.1 and 99.9 02/18/16
Gwinn ModelTowners on the Radio on Fox Sports Marquette 105.1 and 99.9 – GoToGwinn.com – It's good at Gwinn!


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CSUMB Alumnus Featured in CSU-Wide Student Success Profile
SEASIDE, Calif., Feb. 27, 2017 – CSUMB alumnus and owner of J&P Organics Juan Perez was featured by the CSU for his successful ventures after graduating from CSUMB. Perez credits inspirational faculty, summer internships and a strong family support system for his success.
The CSU feature can be viewed below or at the CSU Student Success profile page.