text:
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Because many injury attorneys work with a contingent-fee basis, as well as just earn money if there is a successful resolution to your claim, there is typically little motivation to aim to deal with these kinds of claims by yourself – especially when considerable injuries are entailed.
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Working with a personal injury attorney to represent you after a car mishap implies you will certainly have a specialist working for you– one that is extremely well-informed about the pertinent laws as well as step-by-step regulations that might influence your instance.
An attorney can suggest you of at any time limitations (called laws of limitations) that could disallow you from filing a lawsuit versus the at-fault motorist. In numerous states you should file your legal action within two years of your car accident or be forever banned from filing your legal action. An attorney will certainly additionally be able to inform you regarding any type of unique exemptions to the statute of constraints– for minors, for instance.
Your attorney can submit a lawsuit in your place and will know just how best to mitigate any feasible defenses raised by the opposite side. Furthermore, as soon as your case obtains under means, your attorney will play an important duty in preparing your instance for test– or even mosting likely to test if your instance doesn't settle.
Even though a legal action is hardly ever necessary, the threat of lawsuit uses solid leverage when discussing a reasonable negotiation.
And perhaps most notably, having a lawyer that is educated regarding the law evens the having fun area, especially when you are going up against the experience and also vast resources of a big insurance policy firm.
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There is a lot of job that enters into working out an insurance coverage negotiation and attempting a personal injury legal action. After you have actually remained in a car mishap, handling this lengthy job could be the last point you want to do, assuming you're able. A lawyer can do everything for you.
Whereas this may be your first time dealing with the ins and outs of a crash case, injury lawyers have actually managed all manner of cases and a variety of insurance provider. They have experience getting the essential proof to support your insurance claim, consisting of event cops reports, witness statements, clinical records and also expenses, and employment and also lost wage details.
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LED Ethernet Controller 3
Advanced LED controller, which supports Art-Net and DMX. It can be controlled over LED Strip Studio software 3, any Art-Net software or hardware, lighting consoles, etc.
Also working in stand-alone mode. Advanced web configuration with quick status bar accessible through a web browser is available.
Controls up to 4096 Digital RGB LEDs or 3072 RGBW LEDs, which are 28 full Art-Net universes. Available in 3 different RGB pixel version 4096/2048/1024, which can be upgraded on a higher number of pixels (up to 4096 RGB pixels).
Advance Features
There are many standard features which you already have known from earlier versions of LEC 3 controller. But we like to underline the most interesting features:
- Automatic interpolation
- Active support LSS software and 3rd party Artnet software and hardware
- Web browser interface – configure and test your LEC3 through your mobile device or computer
- DMX and Ethernet Daisy chaining
- Autoplay mode with animation playlist stored on a Micro-SD card
- Easily attachable to DIN profile
- Different pixel-number versions with an optional upgrade (manually or through software on one click)
Technical specification
Weight 469 g Dimensions 142 × 69 × 44 mm Maximum of LEDs
SPI LED Outputs
Maximum of LEDs per Output
Required power
5-24V/ 0.3A (PCB only, wihout the LED strips / LED pixels)
Maximal current
Power connector
pluggable terminal block with 5 mm contact spacing e.g. SH04-5-GY
SPI OUT connector
pluggable terminal block with 5 mm contact spacing e.g. SH04-5-GY
DMX input connector
XLR 3-pin connector (optional 5 pin)
DMX output connector
XLR 3-pin connector (optional 5 pin)
2x RJ-45 connector, internal switch, 100 Mbit/sec
SD Card
Micro SD Card (FAT32, up to 32GB)
142 x 69 x 44 mm
1024-pixels, 2048-pixels, 4096-pixels
Pixel Controller
Art-Net, Digital Controller, Led Controller, LSS Software License, Pixel Controller, RGB, RGBW

subset: commoncrawl


text: 2012/4/29 Kytömaa Lauri <lauri.kytomaa at aalto.fi>: > http://i46.tinypic.com/2cfqivn.png > > Which value would people use for the lanes=*? I think I wouldn't tag any lanes explicitly here. Looks like a residential road. I wouldn't expect many trucks in this zone, but if I were to map more detail I'd add a width-tag. Looks as if 2 cars can pass each other without big problems. cheers, Martin


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Jump Inn Bar & Restaurant
Welcome to Jump Inn Bar & Restaurant.
We're open 7 days a week.
Inspired by our passion for travelling and good food, our in-house bar & restaurant is complete with a relax area featuring retro-style sofas and coffee tables and a spacious dining area with long wooden tables and benches, ideal for big groups of people. Our outdoor beer garden is perfect to enjoy a drink with your friends during the hot summer nights.
Our menu features a delicious range of Mediterranean and Asian specialties and an extensive drink list including craft beers, wine, cocktails & soft drinks. Check out our food & drink menu below.
Opening times
- Monday:
- Tuesday:
- Wednesday:
- Thursday:
- Friday:
- Saturday:
- Sunday:
- Alfresco/Outdoor Dining
- Bar
- Live Music
- Non Smoking
- Takeaway Available
Disabled access available, contact operator for details.
- Quality Tourism Accreditation
- Map
Sign up to receive the latest news, deals and travel information about the Northern Territory. Data privacy
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Your details have been submitted. Please check your email and click the link to confirm your subscription.


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BEIRUT, LEBANON (2:20 P.M.) – The Houthis Movement fired a ballistic missile towards the Saudi Coalition forces in northern Yemen this afternoon.
According to the official media wing of the Houthis, their rocket battalion fired a Badr P-1 short-range missile towards a Saudi Coalition base in the Nihm District of Sanaa.
The Houthis Movement claimed that the ballistic missile managed to hits its intended target, causing significant damage to the installation and heavy casualties within the ranks of the Saudi Coalition.
This latest missile attack by the Houthis Movement comes just hours after the Saudi Coalition launched a big assault along the Yemeni border.
The Saudi Coalition's offensive would ultimately be repelled by the Houthis Movement; however, both sides would end up suffering heavy causalities.
- 122Shares


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Saturday, November 23, 2019
9:30 AM to 10:30 AM CST
Sacred Heart Catholic Church
2201 Northwestern Avenue
Racine, WI 53404
Saturday, November 23, 2019
Sacred Heart Catholic Church
2201 Northwestern Avenue
Racine, WI 53405
At the family's request memorial contributions are to be made to those listed below. Please forward payment directly to the memorial of your choice.
Sacred Heart Catholic Church
2201 Northwestern Avenue
Racine, WI 53402
Life Story / Obituary
Our mother, Sophia M. Wermter, age 88, has joined her husband in eternal life on Saturday, November 16, 2019. She was born in May 8,1931 in Wusen, East Prussia, Germany, daughter of the late Anton and Anna (nee: Wittke) Schlesiger.
She came to Racine in 1957 and was united in marriage to John A. Wermter and together they raised their four children. Sophia cared for John after his stroke for 8 years until he passed in June 1998. Sophia was a longtime member of Sacred Heart Catholic Church, Christian Mothers, Altar Society, DANK, and volunteered at Harmony Club. She was employed by DeRose's Restaurant for over 20 years. Sophia was an excellent cook and baker. She enjoyed traveling back to Germany. Above all she loved spending time with her family, especially her grandchildren.
She will be dearly missed by her children, Monika (Gary) Kunaschk of Racine, Alfred (Julie) Wermter of Apopka, FL, Mary (Mark) Adams of Rockwell, IA, Gretchen (Robert) Rinke of Caledonia; 9 grandchildren; 5 great-grandchildren; brother-in-law, Kurt Brahtz of Germany; sisters-in-law, Anna Maria Oxenknecht, Hedwig (Ludwig) Rose; nieces, nephews, other relatives and many dear friends. In addition to her parents and husband she was preceded in death by her sisters, Monika Schlesiger, Regina Brahtz and Antonie Brahtz.
A Mass of Christian Burial will be celebrated at Sacred Heart Catholic Church, 2201 Northwestern Avenue, on Saturday, November 23, 2019, 10:30 a.m. with Rev. Ricardo Martin officiating. Interment will follow at Holy Cross Cemetery, Hwy 32. Relatives and friends may meet with the family at the church on Saturday from 9:30 a.m. until 10:15 a.m. Memorials to Sacred Heart Catholic Church have been suggested.


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Zeroing in on some birthday cake at my 30th birthday party.
Zeroing in on some birthday cake at my 30th birthday party.
This is our new roommate, Oliver, and this is what his tongue does all the time. He's a very silly dog. It's as though he exists just to wear this.
(We have a few of these costumes left here.)
Fall from Dainty June is now available in our shop! Please remember that our supplies are limited, so please visit DaintyJune.com to view a full list of stockists if we don't have what you want and need. You can also e-mail us and we'll be happy to help!
What do you suppose these faces mean?…
And does it still mean "peace" when you're lying on the couch and this happens?
You can download Lili's "Calming Signals" for free or buy a poster here.
Healthy Chocolate, Organic Chocolate & Fair Trade Chocolate.
Artisan chocolates handmade in the Hudson Valley New York by Lucky Chocolates, Saugerties NY 12477
I was very excited when I received a package in the mail from my friend B.J. with this sweet treat inside. Flavored of cookies and cream, this would be a perfect thank you gift for and fan of squished nose doggies such as myself.
Our mom & dad had a cookie factory in Tuckahoe, NY. Did we mention that? Click on the images below for some close ups of the in ground veggies that are popping up and super happy so far.
I woke this past Saturday morning and watched my usual hour (four hours+) of cooking shows & was inspired by Jamie Oliver to make this meal using all the fresh herbs from the garden. On the menu was Roast Carrots & Beets w/ the Juiciest Pork Chops.


text: Flaming Sword of Groosalugg Jan 26, 2009 18:03:26 GMT -5 Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by Malsad on Jan 26, 2009 18:03:26 GMT -5 Acording to Buffyfest Quote- Angel: After the Fall's writer Brian Lynch seems to love the character as well. He added Groo into the comic and sent him to Hell-A with the rest of the crew. In the most recent issue, #16, Lynch expressed his interest in possibly doing a Groo one-shot awesomely called Savage Sword of Groosalugg. He even spoke to Joss about it!I just thought that this should have its own Tread


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Save the Date for Next Year - October 2-4, 2020!
Internal Server Error
The server encountered an internal error and was unable to complete your request. Either the server is overloaded or there is an error in the application.//www.xkyiq.com/alumni/services/change-address.
Thank You To Our Generous Sponsors!
- The City of North Bay
- TD Meloche Monnex
- The Boat
- Tempo Frames
- Brymark
- All Shelter Sales & Rentals
- Holly Cunningham
- Long and McQuade
- The Food Truck
- The Farm Fashion
- The Cedar Tree
- The Annex by Cheapskates
- Cheapskates
- Oak East Eatery
- Stix and Stones Yarn Boutique
- Raven & Republic
- North Bay Museum
- Syl's Neighbourhood Kitchen
- Creative Learning
For information regarding Homecoming sponsorship opportunities, please contact Alumni Relations at 705-474-3450, ext. 4573. Email: email@example.com.


text: IWC, Portofino and baseball are now strongly tied together by Lee Seung-yuop – a Korean baseball player. Serving 23 years as a major league player, Lee Seung-youp is a popular and legendary sport figure in Seoul. He had held an Asian home run record and a number of other achievements. In addition, Lee's magnificent performance during […]Read More


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CDN stands for Content Delivery Network and the purpose of a CDN is to help deliver content like images and video and other website files to your website users in a quick and efficient way. By doing that, the time to load up your website on your visitor's computer/tablet/phone is greatly reduced making for a much better user experience.
How a CDN works
A CDN is a specially configured network of servers that stores copies of your website files. When your website has a visitor, the CDN will serve website files from a server on its network that is closest, geographically, to the user's location thereby reducing the time it takes for all the files to reach your visitor's web browser.
Why a Content Delivery Network is important for your website
Website speed is important for a couple of reasons:
- Search engines rank fast sites better over slower ones (everything else being equal). Therefore, if search engine rankings are important then A CDN will help your site to rank better.
- Website users typically expect a website to load fast, typically within 3 seconds. If you'r website takes any longer the user is likely to click away to another website rather than wait.
Where can I find a Content Delivery Network
There are both free and paid for solutions available – Techradar have compiled a great list here


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This delightful three bedroom home has a prime residential location on the edge of the town. Ballygar is on the main Roscommon Galway route. Roscommon 10 miles, Athlone and Ballinasloe 18 miles, Galway 38 miles. Shops, Schools, Healthcentre, Chemist, Bank and Sports Facilities are all nearby making this the perfect family or retirement home.
Entrance Hall
Livingroom 5.0 mts X 4.5 mts
Kitchen cum Diningroom 5.0 mts X 4.0 mts
Bed.1 4.2 mts X 2.0 mts ensuite,
Bed.2 3.1 mts X 2.7 mts
Bed.3 3.1 mts X 3.0 mts
Services ; Water. Sewage. Electricity. Oil Fired Central Heating.
The bungalow c. 96 sq.mts. (1,035 sq.ft.) is bright and spacious. It is presented in nice condition with fitted kitchen, flooring, tiled bathroom and ensuite, oil fired central heating, etc.. This is an excellent opportunity to purchase a home in a soughtafter area. Inspection is highly recommended. Viewing by appointment.
Price Region 135,000
Get to know more about this area with our neighbourhood guides, explore property prices lifestyle & more...Neighbourhood Guide >


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XMPP Summit 10 Dev Challenge
From XMPP WIKI
Nokia has again sponsored the Summit 10 Developer's Challenge by offering as the main prize a Nokia N8 phone.
Remember, that while the final judging will be done on a Nokia N8, coding and development is possible on a variety of platforms. See the Developer Resources links below for details.
- Coding can start Monday, 31st of January, at midnight GMT
- All code must be available from a public repository (Gitorious or the like)
- Code must use the Nokia QT framework
- Code must use XMPP
- To be judged your application has to be presented (i.e. run on) to the Judges at FOSDEM - so if your remote hook up with a proxy :)
- All decisions by the Judges are final
- The participants are responsible for any Laws, Fees or Taxes that may be involved by winning
- http://qt.nokia.com
- http://developer.qt.nokia.com/wiki
- https://projects.forum.nokia.com/notificationsapi/wiki
- [hhttp://www.nokiausa.com/find-products/nokian8 Nokia N8 (USA)]
- Nokia N8 (Europe)


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Commenter: Anisia Zamora
Also, don't forget this mantra. "Interact, converse, connect". Having a personality and face online can lure your target market to your site.
If you've embraced online marketing, your hopes for your marketing efforts are probably straightforward: tangible evidence that the money and time you've spent are producing a significant return on investment. Figuring out how to realize those results in the world of online marketing, though, is anything but simple.
Too often, businesses become so focused on growing revenues, building lists, and increasing click-throughs that they forget to develop the personalities of their brands. They become, in a word, boring. Without a palpable life force behind their marketing materials, they're unable to engage users, and all the indicators of marketing success plunge off a cliff.
So how can you keep your marketing materials from becoming the online equivalent of the guy who won't stop talking about the dream he had last night?
Start by taking these steps to banish the boring from your marketing content and keep your brand alive:
Want your list to open more of the emails you send? Then prove that your emails are worth opening. Do this by contacting them only when you actually have something to say -- and only when what you have to say matters to the people you're contacting.
Think of it this way: You don't write an email to your entire personal address book when you want to pass on a great article or image -- you send it to the contacts for whom it's most relevant. Treat relationships with your marketing list the same way and make contact only when you can offer them real value.
If your blog posts or landing pages read like instruction manuals, there's a good chance your readers aren't engaged. But in the era of social online marketing, engagement is key to building loyalty and expanding your presence. When people like something, they share it with their network.
Your brand's unique voice should not only reflect the personality of your business, but it should also speak to your intended market.
Even if you've banished boringness and built a devoted following, you can't expect your list to read your mind. In order to sell, you must call your readers to buy. That's not to say that you need a flashing red button that screams, "BUY THIS NOW," but you do need to indicate clearly to your readers what action they should take.
It's easy to stick to a formula for writing blog posts or emails, but your readers will likely tune out if they see a pattern repeated over and over. Write content of varying lengths. Include sentence fragments in some of your copy. Use questions to spice things up.
From one marketing piece to the next, only your voice should remain unchanged. Think again to your personal emails -- you don't write messages of uniform length every time you communicate with your friends, and you shouldn't stick to a single formula when you communicate with your list.
Save longer messages for first-time announcements, and rely on shorter missives for second or third offers, reminders, and updates.
Once you've captured your audience's attention, keep it by demonstrating how your product or service solves a problem or meets an unmet need. Apple does a great job of this. Instead of listing the amazing features its latest gadget includes, Apple commercials show how much better life is when you can purchase a song on your computer, create a playlist on your iPod, share it with your Facebook friends, and listen to it on your phone -- without plugging anything in or leaving your couch.
These ads sell a lifestyle -- and people camp out overnight to buy it.
Above all, be different. Be yourself. Tell a story. Keep your reader interested. Move your audience to take action. When you do, you'll find that your online marketing efforts yield much more lucrative results.
Michelle Salater is the CEO of Sumèr LLC.
On Twitter? Follow iMedia Connection at @iMediaTweet.
"Silhouette of friends jumping" image via Shutterstock.
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Also, don't forget this mantra. "Interact, converse, connect". Having a personality and face online can lure your target market to your site.
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HIV and tuberculosis co-infection among migrants in Portugal: a brief study on their sociodemographic, clinical, and genomic characteristics AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-22 Mrs. Ana Tavares; Dr. Marta Pingarilho; Dr. Judite Batista; Prof. Miguel Viveiros; Prof. Sónia Dias; Dr. Cristina Toscano; Dr. Perpétua Gomes; Dr. Ana B. Abecasis
HIV and tuberculosis are among the global deadliest diseases. Migrant populations are particularly vulnerable to these infections. Yet, literature is still scarce on the epidemiology of HIV-TB co-infection among migrants. In this study, we characterized native and migrant HIV patients followed in Portuguese hospitals who were diagnosed with TB, regarding their sociodemographic, clinical and genomic
Comparative evaluation of prophylactic SIV vaccination modalities administered to the oral cavity AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-22 Dr. Omkar Chaudhary; Dr. Lingyun Wang; Dr. Deepanwita Bose; Dr. Vivek Narayan; Dr. Ming Te Yeh; Dr. Angela Carville; Dr. John Clements; Raul Andino; Dr. Pamela A. Kozlowski; Dr. Anna Aldovini
Attempts to develop a protective HIV vaccine have had limited success, especially in terms of inducing protective antibodies capable of neutralizing different viral strains. As HIV transmission occurs mainly via mucosal surfaces, HIV replicates significantly in the gastrointestinal tract, and the oral route of vaccination is a convenient one to implement worldwide, we explored three SIV vaccine modalities
Disseminated Mycobacterium avium complex in an HIV-infected with diffuse lymphadenopathy AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-17 Dr. Nicole Harvilla; Dr. Pavan Bhat; Dr. Madhurima Koka; Dr. David James Riedel
Deep-profiling identifies selection of non-synonymous amino acid substitutions in HIV-1 envelope during early infection. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-17 Manickam Ashokkumar,Pattabiraman Sathyamoorthy,Srikanth P Tripathy,Ujjwal Neogi,Luke Elizabeth Hanna
Understanding the evolutionary dynamics of the viruses within an individual at or near the moment of transmission can provide critical inputs for the design of an effective vaccine for HIV infection. In this study, high-throughput sequencing technology was employed to analyze the evolutionary rate in viruses obtained at a single time point from drug-naive recently infected infants and adults in the
Detection of inducible replication-competent HIV-1C provirus despite long-term antiretroviral treatment in perinatally infected adolescents in Botswana. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-16 Dr. Catherine Kegakilwe Koofhethile; Dr. Sikhulile Moyo; Ms. Kenanao Peggy Kotokwe; Mrs. Charlotte Ajeong Chang; Mr. Patrick Mokgethi; Ms. Lorato Muchoba; Mr. Selebogo Mokgweetsi; Dr. Joseph Makhema; Dr. Shahin Lockman; Dr. Simani Gaseitsiwe; Tulio de Oliviera; Dr. Max Essex; Dr. Roger Shapiro; Prof. Phyllis Jean Kanki; Dr. Vladimir Novitsky
While antiretroviral therapy (ART) effectively suppresses HIV replication, the latent reservoir remains the barrier to HIV eradication. It remains unknown whether long term ART impacts levels of inducible replication-competent provirus. To address this knowledge gap, we assessed the proviral reservoir in HIV-1 perinatally infected adolescents having received ART for over 13 years. We recruited 15 vertically
HIV-1 Subtype C tier 3 viruses have increased infectivity as compared to tier 2 viruses. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-16 Thandeka Moyo,Fatuma H Guleid,Michael Schomaker,Carolyn Williamson,Jeffrey R Dorfman
A primary concern of an antibody-based HIV-1 therapy is the virus' ability to rapidly escape antibody responses. Therefore, we investigated the relationships between antibody neutralization sensitivity, viral phenotype and infectivity in 13 subtype C viruses using a HeLa transfectant-based assay. We observed that the seven tier 3 viruses exhibited higher infectivity than the tier 2 viruses, suggesting
NO SIGNIFICANT INCREASE IN BODY FAT MASS IN NAIVE HIV-INFECTED PATIENTS STARTING RALTEGRAVIR PLUS TENOFOVIR DISOPROXIL FUMARATE/EMTRICITABINE. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-16 Leonardo Calza,Marco Borderi,Vincenzo Colangeli,Fabio Esposito,Maddalena Giglia,Isabella Bon,Maria Carla Re
A significant weight gain has been reported in HIV-infected patients starting combination antiretroviral therapy (cART) including integrase strand transfer inhibitors (INSTIs), but clinical data about changes in body fat mass are still lacking. An observational, retrospective analysis was made to evaluate changes in body fat mass and weight in 39 cART-naïve patients initiating a first antiretroviral
Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-14 Karine Dubé,Danielle M Campbell,Kelly E Perry,John T Kanazawa,Parya Saberi,John A Sauceda,Tonia Poteat,David Evans
A growing body of research is beginning to elucidate reasons people living with HIV (PLWHIV) might prefer oral daily antiretroviral treatment (ART) compared with emerging long-acting ART (LA-ART) or HIV remission strategies under investigation. Our objective is to provide qualitative insights into the reasons why PLWHIV might prefer one of these HIV control therapies over others. From May to August
Tenofovir Alafenamide Fumarate Therapy for HIV Treatment: Cardiometabolic and Renal Safety. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Vasilis Petrakis,Periklis Panagopoulos,Stella Papachristou,Nikolaos Papanas,Irene Terzi,Grigorios Trypsianis,Dimitrios Papazoglou
Antiretroviral treatment based on tenofovir alafenamide fumarate (TAF) is increasingly recommended, as it maintains the viral suppression and improves renal function and bone density in comparison with tenofovir disoproxil fumarate (TDF). We carried out a retrospective cohort study including experienced patients who switched treatment from TDF to TAF. Serum lipids and glucose, renal function, body
Mitochondrial Dysfunction and Insulin Resistance in Pubertal Youth Living with Perinatally Acquired HIV. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Greg S Gojanovich,Denise L Jacobson,Jennifer Jao,Jonathan S Russell,Russell B Van Dyke,Daniel E Libutti,Tanvi S Sharma,Mitchell E Geffner,Mariana Gerschenson
Mitochondrial dysfunction (MD) is linked to cardiometabolic complications, such as obesity and insulin resistance (IR), the frequencies of which are higher in adults living with HIV infection and receiving combination antiretroviral therapies (ARV). ARV-treated youth living with perinatally acquired HIV infection (YLPHIV) may be especially susceptible to IR due to long-term exposure to both factors
A Geographic Hotspot and Emerging Transmission Cluster of the HIV-1 Epidemic Among Older Adults in a Rural Area of Eastern China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Jun Jiang,Qin Fan,Jiafeng Zhang,Mingyu Luo,Xiaobei Ding,Xiaohong Pan,Jianmin Jiang,Liyang Qiu
Despite the implementation of health education and free condom distribution for decades, the HIV/AIDS epidemic among older adults in China shows no sign of declining. This study aims to identify HIV transmission patterns and pathways in a rural county area and provide insight for developing effective HIV prevention strategies among older adults. Epidemiological field surveys combined with phylogenetic
Rapid Uptake of Pre-Exposure Prophylaxis After Significant Price Reduction in Germany Highlights Importance of Pre-Exposure Prophylaxis Accessibility. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Patryk Mysior,Erik Tenberken,Melanie Stecher,Jörg-Janne Vehreschild,Armin Schafberger,Ines Perea,Anna-Lena Brillen,Barbara Bartmeyer,Stefan Esser,Viviane Bremer,Ulrich Marcus,Daniel Hoffmann,Hendrik Streeck
Pre-Exposure Prophylaxis (PrEP) has been widely accepted as an effective method to prevent HIV infections, but high costs precluded a widespread use in Germany. A novel distribution pathway of tenofovir-disoproxil fumarate and emtricitabine PrEP was implemented, which reduced monthly PrEP costs by 16-fold in Germany. Over a period of 6 months, we recorded prescription data, demographics, and sexual
HIV Infection Does Not Increase 10-Week Mortality of Chinese Cryptococcal Meningitis Patients. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Lijun Xu,Jianhua Yu,Bin Zheng,Feifei Su,Zongxing Yang,Yongzheng Guo,Ran Tao,Xiahong Dai,Ying Huang,Jinchuan Shi,Zhongdong Zhang,Yaokai Chen,Biao Zhu
The role of HIV infection in precipitating different clinical features in cryptococcal meningitis (CM) patients remains controversial. One hundred twelve CM patients living with HIV/AIDS (CM+HIV+ patients) and 112 CM patients living without HIV/AIDS (CM+HIV− patients) were enrolled after propensity score matching. Demographic characteristics, symptoms, routine blood tests, and biochemical and cerebrospinal
Prevalence of Insulin Resistance in Adults Living with HIV: Implications of Alcohol Use. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Liz Simon,Tekeda F Ferguson,Curtis Vande Stouwe,Meghan M Brashear,Stefany D Primeaux,Katherine P Theall,David A Welsh,Patricia E Molina
Unhealthy alcohol use is prevalent among persons living with HIV (PLWH). Aging and increased survival of PLWH on antiretroviral therapy (ART) are complicated by metabolic dysregulation and increased risk of insulin resistance (IR) and diabetes mellitus. The objective of this study was to determine the prevalence and association of IR with unhealthy alcohol use in adult in-care PLWH. A cross-sectional
Admission C-Reactive Protein-to-Albumin Ratio Predicts the 180-Day Mortality of AIDS-Related Pneumocystis Pneumonia. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Hui Wang,Yufei Chang,Zhi-Zhang Cui,Zhi-Juan Liu,Shan-Fang Ma
Assessment tools are necessary for the adequate stratification of patients with AIDS-related pneumocystis pneumonia (PCP). The aim of this study was to evaluate the ability of severity assessment scores and inflammation- and nutrition-based parameters for predicting the 180-day mortality of AIDS-related PCP. This was a retrospective cohort study of patients with AIDS-related PCP admitted at the Beijing
A Systematic Approach to HIV-1 Vaccine Immunogen Selection. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Alexander Bontempo,Maria M Garcia,Naylene Rivera,Mark J Cayabyab
A tremendous loss of financial and human resources from seven large-scale HIV vaccine efficacy trials suggest a need for a systematic approach to vaccine selection. We conducted a systematic analysis of three important envelope glycoprotein (Env) vaccine candidates: BG505 SOSIP.664, 1086.C gp140, and 1086.C gp120 to determine the most promising by comparing their structure and antigenicity. We found
Short Communication:Transgender Women on Feminizing Hormone Therapy Demonstrate a Distinct Rectal Mucosal Transcriptome from Cisgender Men. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Cassie G Ackerley,James M Billingsley,Gregory K Tharp,Praveen K Amancha,Vin Tangpricha,S Abigail Smith,Rama Amara,Steven E Bosinger,Colleen F Kelley
Among transgender women (TGW), the effects of feminizing hormone therapy use on rectal mucosal (RM) HIV transmission are largely unknown. In this small pilot study, we compared the RM transcriptome in TGW utilizing feminizing hormone therapy with a group of cisgender men who have sex with men (MSM) engaging in condomless receptive anal intercourse (AI) and to a group of cisgender men who had never
Associations Between Personality Traits and Patterns of HIV Risk Behaviors Among Young Men Who Have Sex with Men in China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Wei Wang,Yinmei Yang,Mohammedhamid Osman Kelifa,Shiyue Li,Yue Cao,Xiaoyan Li,Hong Yan
This study aimed to ascertain the patterns of human immunodeficiency virus (HIV) risk behaviors among young men who have sex with men (YMSM) and explore the relationships between personality traits and patterns of HIV risk behaviors. Three hundred and seventy-five YMSM were recruited from March to December 2013, in central China. Latent class analysis (LCA) was utilized to identify underlying subgroups
High Levels of Acquired HIV Drug Resistance Following Virological Nonsuppression in HIV-Infected Women from a High-Risk Cohort in Uganda. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-08 Farouk Segujja,Jonah Omooja,Sandra Lunkuse,Maria Nanyonjo,Stella E Nabirye,Faridah Nassolo,Daniel L Bugembe,Nicholas Bbosa,David P Kateete,William Ssenyonga,Yunia Mayanja,Rebecca N Nsubuga,Janet Seeley,Pontiano Kaleebu,Deogratius Ssemwanga
HIV drug resistance (HIVDR) is of increasing health concern, especially among key populations. We investigated the prevalence of virological suppression (VS), prevalence and correlates of HIVDR in HIV-infected women, enrolled in a high-risk cohort. We enrolled 267 women initiated on first-line antiretroviral therapy (ART) between 2015 and 2018. Participants' plasma samples were analyzed for HIV RNA
The Genetic Diversity of HIV-1 Within Antiretroviral-Naive Outpatients in Ganzhou, China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-09 Ying-Na Xie,Yu-Ning Zhang,Si-Wei Cheng,Dan-Dan Huang,Bing-Yu Xie,Zhen Huang,Yan-Heng Zhou,Da-Qing Zhu,Xin Chen
To explore the molecular epidemiological status of human immunodeficiency virus type 1 (HIV-1) in Ganzhou, China, eight HIV-1–positive outpatients were recruited from July 5 to 21, 2018. Six HIV-1 near-full-length sequences were amplified and sequenced from the plasma samples that were collected before the patients' antiretroviral treatments. Phylogenetic and bootscan analyses revealed that one of
Trends in Transmitted Drug Resistance in Treatment-Naive HIV Patients in Korea. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-07 Eun Ju Jung,Sun Hee Lee,Shinwon Lee,Jeong Eun Lee,Soon Ok Lee,Sohee Park,Hyung-Hoi Kim,Jin Suk Kang,Heung Jung Woo
Transmitted drug resistance (TDR) in treatment-naive HIV patients can contribute to failure of initial antiretroviral therapy. In Korea, there has been a gradual increase in TDR, but the recent increase in the use of integrase strand transfer inhibitors (INSTIs) could affect TDR trends and INSTI resistance mutations. We evaluated the patterns of TDR in newly diagnosed HIV patients over time from 2011
A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-07 Scott Sherrill-Mix,Kaleigh Connors,Grace M Aldrovandi,Jason M Brenchley,Charles Boucher,Frederic D Bushman,Ronald G Collman,Satya Dandekar,Nichole R Klatt,Laurel A Lagenaur,Roger Paredes,Gilda Tachedjian,Jim A Turpin,Alan L Landay,Mimi Ghosh
In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HIV infection with the microbiome and the development and clinical trials of microbiome-based
New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable? AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-03 Rajeev K Mehlotra
C–C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4+ memory T cells. Polymorphisms in CCR5 regulate CCR5 expression, which, in turn, influences HIV infection acquisition and subsequent disease progression. Among these polymorphisms
Beyond Interpretation: The Unmet Need for Linguistically and Culturally Competent Care for Latinx People Living with HIV in a Southern Region with a Low Density of Spanish Speakers. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-02 Jacqueline E Sherbuk,Kristen Petros de Guex,Diego Anazco Villarreal,Sarah Knight,Kathleen A McManus,Tabor Flickinger,Rebecca Dillingham
Latinx people living with HIV (PLWH) experience disparities in health outcomes and face unique barriers to care related to language, intersectional stigma, and immigration status. We aimed to explore the lived experience of Spanish-speaking Latinx PLWH in the nonurban South to better understand how to improve care for this minority language population. We conducted semistructured interviews with 22
Genetic diversity, complicated recombination and deteriorating drug resistance among HIV-1 infected individuals in Wuhan, China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-02 Yan Zhang,Yanhe Luo,Yang Li,Ya Wu Zhang,Wenying Wu,Hong Peng,Lijun Han,Yaokai Chen,Lianguo Ruan,Rongge Yang
To identify genotype distribution and drug resistance in people infected by HIV-1 in Wuhan, China, 105 infected people diagnosed with HIV-1 from January to December in 2019 were involved in this study. 98 gag genes, 101 PR genes and 98 RT genes were successfully amplified. The phylogenetic analysis results showed that CRF01_AE (38.2%) and CRF07_BC (35.3%) were the two dominant genotypes, followed by
Prevalence of antiretroviral drug resistance mutations among pre-treatment and ART-failured HIV patients in Uzbekistan. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-01 Adkhamjon Mamatkulov,Evgeniya Kazakova,Nargiz Ibadullaeva,Elizaveta Joldasova,Allabergan Bayjanov,Erkin Musabaev,Nataliya Kan,Dildora Mustafaeva,Aleksey Vladimirovich Lebedev,Marina Bobkova,Elena Kazennova,Lev Zohrabyan
Objective: To evaluate the national prevalence of antiretroviral therapy (ART)-resistant HIV-1 viruses among both ART-initiators (pre-treatment resistance, PDR) and ART-failured HIV patients in Uzbekistan. Methods: A nation-wide, cross-sectional active HIV-1 PDR surveillance was conducted in Uzbekistan from 2015-2016. In total, 713 blood plasma samples from adults were collected including samples from
Genetic characteristics of CRF12_BF first identified in Guangdong Province, China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-09-01 Yun Lan,Xiang He,Ruolei Xin,Linghua Li,Xuhe Huang,Xizi Deng,Xiaoping Tang,Weidong Jia,Weiping Cai,Fengyu Hu
Multiple HIV-1 genotypes were found circulating in Guangdong Province, China, as this province is located in South China and has a high frequency of international trade. Here, we report the near full-length genome of CRF12_BF that was identified from a male patient in Guangzhou city, Guangdong Province; this is the first time CRF12_BF has been reported in mainland China. The near full-length genome
Skipped over - tuning NK cells towards HIV through alternative splicing. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-30 Daniel Ram,Kyle Kroll,R Keith Reeves
Natural killer (NK) cells provide some of the earliest immune responses to infection, but when viruses manipulate or perturb the immune environment to alter NK cell function this places the host at a disadvantage. Indeed, others and we observe that in the context of HIV/SIV infection, although NK cells are not infected they can become dysfunctional over time. Several works have characterized protein
Factors Associated with Nonsuppression of HIV Infection in the Spanish VACH Cohort. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Bernardino Roca,
We aim to determine the prevalence of HIV nonsuppression and factors associated with it. This is a cross-sectional multicenter study carried out in January 2016 with data of the VACH Cohort, a registry participated by 23 hospitals from most regions of Spain. The prevalence of HIV nonsuppression, defined as HIV RNA ≥200 copies/mL, is documented. The possible association of HIV nonsuppression with sociodemographic
Impact of Fat Changes on the Effect of Protease Inhibitors on Lumbar Spine Bone Mineral Density Changes with Antiretroviral Therapy Initiation. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Joshua Garza,Carlee Moser,Douglas W Kitch,Judith S Currier,Michael P Dubé,James Stein,Grace McComsey,Todd T Brown
People living with HIV (PLWH) who are on protease inhibitor (PI)-containing regimens have been shown to have increases in visceral adipose tissue (VAT) and a greater decrease in spine bone mineral density (BMD) than those receiving non-PI regimens when initiating treatment. This increase in VAT has been hypothesized to falsely lower spine BMD measured via dual-energy X-ray absorptiometry, suggesting
Proteasomal Inhibition Potentiates Latent HIV Reactivation. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Daniele C Cary,B Matija Peterlin
Despite the success of antiretroviral therapy (ART), ART fails to eradicate the virus and HIV cure has remained beyond the reach of current treatments. ART targets replicating virally infected but not latently infected cells, which have limited expression of factors important for proliferation and cellular activity, including positive transcription elongation factor b (P-TEFb) and nuclear factor κB
Access to HIV Viral Load Testing and Antiretroviral Therapy Switch Practices: A Multicountry Prospective Cohort Study in Sub-Saharan Africa. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Pascale Ondoa,Andrea A Kim,T Sonia Boender,Guoqing Zhang,Stefanie Kroeze,Jeffrey Wiener,Tobias Rinke de Wit,John Nkengasong,
Poor access to HIV viral load (VL) testing prevents the timely monitoring of HIV treatment adherence and efficacy. Factors enabling clinical benefits of VL testing when added to local standards of care, can inform the development of more cost-effective routine VL scale-up plans. We compared antiretroviral therapy (ART) switch practices in 13 clinics across 6 countries, with full (N = 8), phasing-in
HIV-DRLink: A Tool for Reporting Linked HIV-1 Drug Resistance Mutations in Large Single-Genome Data Sets Using the Stanford HIV Database. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Wei Shao,Valerie F Boltz,Junko Hattori,Michael J Bale,Frank Maldarelli,John M Coffin,Mary F Kearney
The prevalence of HIV-1 drug resistance is increasing worldwide and monitoring its emergence is important for the successful management of populations receiving combination antiretroviral therapy. It is likely that pre-existing drug resistance mutations linked on the same viral genomes are predictive of treatment failure. Because of the large number of sequences generated by ultrasensitive single-genome
Identification of a Novel HIV-1 Unique CRF01_AE/C Recombinant in Yan'an City, Shaanxi Province. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-27 Si-Wei Cheng,Feng Qi,Ying-Na Xie,Na Wang,Yan-Ping Chen,Li-Li Gao,Xin Chen,Yan-Heng Zhou
A wide variety of HIV-1 recombinants are constantly discovered in China. Comprehensively monitoring the genetic diversity of HIV-1 is very essential for understanding the molecular epidemiology and controlling the spread of the HIV-1 epidemic. In this study, we presented a novel HIV-1 unique CRF01_AE/C recombinant (19YA001) isolated from a female patient infected HIV-1 through heterosexual transmission
CAROTID ARTERY PLAQUE BURDEN IN HIV IS ASSOCIATED WITH SOLUBLE MEDIATORS AND MONOCYTES. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-29 Dominic Chow,Makoa Mau,Howard Hodis,Jakrin Kewcharoen,Yanjie Li,Chathura Siriwardhana,Scott A Souza,Brooks Mitchell,Scott Bowler,Ivo Novita SahBandar,Louie Mar A Gangcuangco,Iain MacPherson,Lishomwa Ndhlovu,Cecilia Shikuma
Background Maximum carotid plaque thickness (MCPT) measures the largest plaque thickness in the carotid artery and reflects atherosclerosis plaque burden. MCPT may be a better predictor of cardiovascular disease than carotid artery intima-media thickness (cIMT) because it identifies potential unstable arterial atherosclerosis plaques. We assessed the relationships of monocyte (MO) and T-cell populations
Analysis of CRISPR/Cas9 Guide RNA Efficiency and Specificity Against Genetically Diverse HIV-1 Isolates. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-26 Katherine J Sessions,Yun Yue Chen,Christine A Hodge,Taylor R Hudson,Susan K Eszterhas,Matthew S Hayden,Alexandra L Howell
Gene editing approaches using CRISPR/Cas9 are being developed as a means for targeting the integrated HIV-1 provirus. Enthusiasm for the use of gene editing as an anti-HIV-1 therapeutic has been tempered by concerns about the specificity and efficacy of this approach. Guide RNAs (gRNAs) that target conserved sequences across a wide range of genetically diverse HIV-1 isolates will have greater clinical
The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-26 Stephanie Shiau,Alexis A Bender,Jane A O'Halloran,Erin Sundermann,Juhi Aggarwal,Keri N Althoff,Jason V Baker,Steven G Deeks,Linda P Fried,Stephen Karpiak,Maile Karris,Thomas Marcotte,Jean B Nachega,Joseph B Margolick,Kristine M Erlandson,David J Moore
With increasing effectiveness of antiretroviral therapy, people with HIV (PWH) are living longer and the prevalence of older PWH continues to increase. Accordingly, PWH are experiencing an increased burden of age-related comorbidities. With this shifting demographic, clinicians and researchers face additional challenges in how to identify, address, and manage the complex intersections of HIV- and aging-related
People living with HIV in the CoVid-19 era: a case report. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-25 Damiano Farinacci,Arturo Ciccullo,Alberto Borghetti,Elena Visconti,Enrica Tamburrini,Immacolata Maria Izzi,Roberto Cauda,Simona Di Giambenedetto,Federico Pallavicini
Little is known about the characteristics of SARS-CoV-2 infection in immunosuppressed people living with HIV. This report describes a case of a HIVinfected patient with Pneumocystis jirovecii pneumonia and CoVid-19 who died because of treatment's side effect. This case teaches us that fragile people may need different therapeutic strategies.
Choosing the Right Program for the Identification of HIV-1 Transmission Networks from Nucleotide Sequences Sampled from Different Populations. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-24 Nicholas Bbosa,Deogratius Ssemwanga,Pontiano Kaleebu
HIV-TRAnsmission Cluster Engine (HIV-TRACE) and Cluster Picker are some of the most widely used programs for identifying HIV-1 transmission networks from nucleotide sequences. However, choosing between these tools is subjective and often a matter of personal preference. Because these software use different algorithms to detect HIV-1 transmission networks, their optimal use is better suited with different
High-Risk Sexual Practices Contribute to HIV-1 Double Infection Among Men Who Have Sex with Men in Madrid. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-19 Concepción Casado,María Pernas,Marta Rava,Oskar Ayerdi,Mar Vera,Raquel Alenda,Pilar Jiménez,Félix Docando,Isabel Olivares,Angel Zaballos,José Luis Vicario,Carmen Rodríguez,Jorge Del Romero,Cecilio Lopez-Galindez
Data on the prevalence of double infection (DI) in HIV individuals are lacking in Spain. To fill this gap, we analyzed the prevalence of DI in a cohort of men who have sex with men (MSM) and examined factors contributing to DI. We selected 81 MSM attending Centro Sanitario Sandoval, a sexually transmitted diseases clinic in Madrid. We obtained by ultra-deep sequencing the proviral sequences in gag
Near Full-Length Genomic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF106_cpx) Identified Among Heterosexuals in China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-19 Jiajia Zhou,Miaomiao Li,Chen Min,Yanling Ma,Yiming Shao,Hui Xing
In our study, we reported a novel CRF01_AE/B/C human immunodeficiency virus type 1 (HIV-1) recombinant form among six epidemiologically unlinked heterosexual patients in Yunnan, China. It was named CRF106_cpx (this is temporary as we have not received the circulating recombinant form [CRF] number from HIV databases). After sequencing and analyzing of the near full-length genome, we found that CRF106_cpx
Near Full-Length Genomic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF107_01B) Identified among Men Who Have Sex with Men in Heilongjiang province of China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-21 Xiao Song,Jiajia Zhou,Miaomiao Li,Yi Feng,Hui Xing,Wei Sun
We reported a novel HIV-1 circulating recombinant form among four epidemiologically unlinked patients through men having sex with men (MSM) in HeiLongjiang Province, China. It was named CRF107_01B (this is temporary as we have not received the CRF number from HIV databases). A near full-length genome (NFLG) phylogenetic tree showed that CRF107_01B was generated by two CRF01_AE segments that was described
Gut-Homing CD4+ T Cells Are Associated with the Activity of Gastritis in HIV-Infected Adults. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-17 Hidenori Sato,Yasunori Ota,Yasutoshi Kido,Takashi Matsumoto,Yasuo Matsubara,Tetsuro Matano,Yoshihiro Hirata,Ai Kawana-Tachikawa,Yoshio Yamaoka,Hiroshi Yotsuyanagi,Eisuke Adachi
Previous studies have shown that HIV-infected individuals were less susceptible to chronic gastritis and Helicobacter pylori infection. Th1 and Th17 cells are important components of the immune response to H. pylori in adults. We investigated the relative importance of Th1 versus Th17 responses for mucosal inflammation and protection. We conducted a prospective cross-sectional study to evaluate the
HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-17 Rui Zeng,Doudou Ren,Xiaowen Gong,Min Wei,Liying Gao,Aiping Yu,Defa Zhang,Yuqiang Mi,Ping Ma
Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from January 2016 to November 2019. The target fragment in the pol gene was sequenced after
Circulating Mitochondrial DNA and Lipopolysaccharide-Binding Protein but Not Bacterial DNA Are Increased in Acute Human Immunodeficiency Virus Infection. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-17 Milena Nasi,Simone Pecorini,Sara De Biasi,Margherita Digaetano,Johanna Chester,Beatrice Aramini,Domenico Lo Tartaro,Marcello Pinti,Anna De Gaetano,Lara Gibellini,Anna Vittoria Mattioli,Cristina Mussini,Andrea Cossarizza
Microbial translocation has been suggested as a major driver of chronic immune activation HIV infection. Thus, we compared the extent of microbial translocation in patients with acute HIV infection and patients followed after CD4-guided structured treatment interruption (STI) by measuring different circulating markers: (1) lipopolysaccharide (LPS)-binding protein (LBP), (2) bacterial DNA, (3) soluble
Progressive Renal Impairment in an Older Patient with Coronavirus Disease 2019: A Case Report and Literature Review. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-13 Dan Zhu,Jilin Xu,Hui Chen,Saibin Wang,Long Yu
Advanced age is a high-risk factor for exacerbation of coronavirus disease 2019 (COVID-19), which causes a high rate of mortality. Therefore, it is important to strengthen the warning and monitoring of severe patients, and early identify the severe and critically severe types in time in the clinical treatment of COVID-19. Moreover, it is necessary to pay attention to the adverse reactions and damage
2018-2019 Update on the Molecular Epidemiology of HIV-1 in Indonesia. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-16 Siti Qamariyah Khairunisa,Ni Luh Ayu Megasari,Shuhei Ueda,Waras Budiman,Tomohiro Kotaki,- Nasronudin,Masanori Kameoka
The HIV-1 epidemic has continued to grow in Indonesia; however, continuous updates on the epidemiology of HIV-1 in Indonesia remain challenging because it is the biggest archipelago in the world. Furthermore, the emergence of HIV drug resistance (HIVDR) has had a negative impact on the treatment of infected individuals. In the present study, we performed HIV-1 subtyping and the detection of HIVDR in
Assisters Succeed in Insurance Navigation for People Living with HIV and People at Increased Risk of HIV in a Complex Coverage Landscape. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-12 Kathleen A McManus,Amy Killelea,Ethan Honeycutt,Zixiao An,Jessica Keim-Malpass
Insurance enrollment is complex for people living with HIV (PLWH) and people at increased risk for HIV, in part, owing to needing to ensure access to adequate provider networks and appropriate formularies. Insurance for PLWH facilitates access to HIV care/treatment and, ultimately, viral suppression, which has the individual benefit of longevity and the public health benefit of decreased HIV transmission
CD4+:CD8+ T Cell Ratio Normalization and the Development of AIDS Events in People with HIV Starting Antiretroviral Therapy. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-11 Hajra Okhai,María Jesús Vivancos-Gallego,Teresa Hill,Caroline A Sabin
We identify factors associated with the normalization of the CD4+:CD8+ T cell ratio among UK Collaborative HIV Cohort study participants, and describe the association of the CD4+ and CD8+ T cell counts and the CD4+:CD8+ T cell ratio, with the risk of new AIDS events among individuals who achieve a suppressed viral load. Participants initiating combination antiretroviral therapy (cART) after 2006 with
What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications? AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-10 Lena Al-Harthi,Edward Campbell,Julie A Schneider,David A Bennett
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome in a subset of patients and is a primary driver of acute morbidity in infected persons. However, it is becoming increasingly clear that SARS-CoV-2 infection
HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-08-10 Sello Given Mikasi,Darren Isaacs,George Mondinde Ikomey,Henerico Shimba,Ruben Cloete,Graeme Brendon Jacobs
HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of
Effects of Depot Medroxyprogesterone Acetate, Copper Intrauterine Devices, and Levonorgestrel Implants on Early HIV Disease Progression. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-30 Charles S Morrison,G Justus Hofmeyr,Katherine K Thomas,Helen Rees,Neena Philip,Thesla Palanee-Phillips,Kavita Nanda,Gonasagrie Nair,Maricianah Onono,Timothy D Mastro,Maggie Lind,Renee Heffron,Vinodh Edward,Jen Deese,Mags Beksinska,Ivana Beesham,Jeffrey S A Stringer,Jared M Baeten,Khatija Ahmed,
Limited data exist on the effects of contraceptives on HIV disease progression. We studied the association between intramuscular injectable depot medroxyprogesterone acetate (DMPA-IM), the copper intrauterine device (IUD), and the levonorgestrel (LNG) implant on markers of HIV disease progression at the time of HIV detection and 3 months postdetection and time from detection to CD4 count <350 cells/mm3
Rate of the HIV Transmission and Associated Factors Among HIV-Exposed Infants in Guangxi, China: 2014-2019. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Jiangyang Zhao,Qiaopei Chen,Chunyun Fu,Qinghua Qin,Haifeng Huang,Yuanyuan Feng,Yuchen Wei,Yan Li,Aidan Huang,Qingqing Xu,Shangyang She
This study aims to evaluate the epidemiological characteristics of mother-to-child transmission (MTCT) of HIV and identify the possible factors leading to infant HIV infection using a retrospective cohort study of early infant diagnosis (EID). Information on a total of 3,145 exposed infant–mother pairs was collected from the EID platform from July 2014 to December 2019. The MTCT rate was 2.1%. Spatial–temporal
Endogenous Hormones and Antiretroviral Exposure in Plasma, Cervicovaginal Fluid, and Upper-Layer Packed Cells of Malawian Women Living with HIV. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Melanie R Nicol,Mackenzie L Cottrell,Amanda H Corbett,Lameck Chinula,Gerald Tegha,Frank Z Stanczyk,Stacey Hurst,Athena P Kourtis,Jennifer H Tang
Overlap in metabolism pathways of endogenous female sex hormones and antiretroviral drugs may lead to altered exposure to these compounds. In a family planning clinic in Lilongwe, Malawi, blood, blood cell, and cervicovaginal fluid (CVF) samples from seventy-three HIV positive Malawian women taken in follicular and luteal menstrual phases were assessed for estradiol and progesterone by chemiluminescent
Comparison of HIV Incidence in the Zimbabwe Population-Based HIV Impact Assessment Survey (2015-2016) with Modeled Estimates: Progress Toward Epidemic Control. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Elizabeth Gonese,Godfrey Musuka,Leala Ruangtragool,Avi Hakim,Bharat Parekh,Trudy Dobbs,Yen T Duong,Hetal Patel,Mutsa Mhangara,Owen Mugurungi,Munyaradzi Mapingure,Suzue Saito,Amy Herman-Roloff,Lovemore Gwanzura,Beth Tippett-Barr,Peter H Kilmarx,Jessica Justman
Between October 2015 and August 2016, Zimbabwe conducted the Zimbabwe Population-Based HIV Impact Assessment (ZIMPHIA) cross-sectional survey to determine progress toward epidemic control. Of 25,131 eligible adults aged 15–64 years, 20,577 (81.8%) consented to face-to-face questionnaire and biomarker testing in this nationally representative household survey. Home-based rapid HIV testing was performed
Association of Pain and Pain Medication Use with Multiple Characteristics of Older People Living with HIV. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Maile Y Karris,Jeff Berko,Peter D Mazonson,Theoren M Loo,Frank Spinelli,Andrew Zolopa
People living with HIV (PLWH) experience chronic pain that may impact function. Gaps in knowledge exist for factors that impact pain and pain medication use in older (age 50+) PLWH. Data for this study were obtained from the Aging with Dignity, Health, Optimism and Community (ADHOC) cohort, an observational study of older PLWH from 10 clinics across the United States. Participants self-reported socioeconomic
Physical Therapy for Chronic Pain Mitigation and Opioid Use Reduction Among People Living with Human Immunodeficiency Virus in Atlanta, GA: A Descriptive Case Series. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Sara D Pullen,Christi Acker,Haemi Kim,Morgan Mullins,Payton Sims,Holly Strasbaugh,Samantha Zimmerman,Carlos Del Rio,Vincent C Marconi
People living with HIV (PLH) may be at increased risk of experiencing both chronic pain and opioid dependence. Physical therapy (PT) has been shown to be effective as a nonpharmacological strategy for mitigating chronic pain in the general population, however, there is gap in research investigating PT to reduce chronic pain and opioid use among PLH. This case series describes the feasibility of an
Risk Factors of Hypovitaminosis D in HIV-Infected Patients on Suppressive Antiretroviral Therapy. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Tomasz Mikuła,Mariusz Sapuła,Magdalena M Suchacz,Joanna Kozłowska,Dagny Krankowska,Wojciech Stańczak,Alicja Wiercińska-Drapało
Low serum vitamin D levels are very common in human immunodeficiency virus (HIV)-infected patients. In our cross-sectional study, we investigated the association between 25-hydroxyvitamin D (25(OH)D) levels and serum inflammation markers [C-reactive protein (CRP), white blood cells (WBC), D-dimers, platelet count (PLT)] in 148 HIV-infected patients on combined antiretroviral therapy [28 on tenofovir
Treatment Experience and Repeat Pregnancy Impact the Effectiveness of Non-Nucleoside Reverse Transcription Inhibitor-Highly Active Antiretroviral Therapy for the Prevention of Mother to Child Transmission of Human Immunodeficiency Virus. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Indira B Martin,Stanley Read,Richard Harrigan,M Perry Gomez
Non-nucleoside reverse transcription inhibitor (NNRTI)-containing antiretroviral therapy (ART) for the prevention of mother to child transmission (PMTCT) of human immunodeficiency virus (HIV) has led to dramatic reductions in perinatal HIV infection in resource-constrained settings. Nonetheless, PMTCT programs are complicated by repeat pregnancies, in which long-term or repeat exposures to PMTCT regimens
Chemokine Coreceptor Usage Among HIV-1 Drug-Naive Patients Residing in the Rural Eastern Cape, South Africa. AIDS Res. Hum. Retrovir. (IF 1.765) Pub Date : 2020-07-31 Tennison Onoriode Digban,Benson Chucks Iweriebor,Uchechukwu U Nwodo,Anthony Ifeanyi Okoh,Larry Chikwelu Obi


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Online Stories:
- 2015 State of the Synod
- Web Exclusive: Are the unborn human?
- Web Exclusive: Good, Right and Beautiful
- Web Exclusive: This Is Not Your Own Doing
- Web Exclusive: Forever Holding Our Peace
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From the editor
Not long ago, I was speaking with a young pastor in a small town who was disheartened by his congregation's indifference, manifested in part in its lack of desire to bear witness and show mercy to the community. He was downloading books to his iPad on the subject and researching options with fellow pastors, but he was still clearly frustrated. I asked if he'd spoken with the Rev. Todd Kollbaum, director of LCMS Rural & Small-Town Mission, to learn what resources the Synod could provide. He hadn't. "I didn't even think of that option," he admitted.
But that's exactly what Rural & Small-Town Mission, and the other ministries of The Lutheran Church—Missouri Synod, exist to do: to point you to Christ, and in so doing, to all the ways He enables you to care for and serve your neighbor. That's why, in this issue of The Lutheran Witness, you'll get an in-depth look at the LCMS ministries, resources and people ready to serve you. You'll get a clearer look at the work the Lord is accomplishing both nationally and internationally. And you'll see the challenges we face, the Synod's financial status and recent trends in giving.
From LCMS Black Ministry to the Global Seminary Initiative, from LCMS Urban & Inner-City Mission to LCMS Disaster Response, the Lord is working good for His people. There is much to pray about, to be sure, but there is also great cause for giving thanks. It's my hope this issue of the magazine will cause you to do both.
For you!
Adriane Heins, Managing Editor
The Lutheran Witness


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how about the entire 400ex clutch plates by the norm and him saying not trying to argue with you and trying to be nice but no no he was telling you that you were wrong and you werent having it and so you argued back and that is why we are still talking about how all you do is argue.You don't know what you are talking about, go back and re-read what I wrote. No one correct me, the information posted is an assumption only, not based on what really happened. I merely posted the real facts, and not based on any assumptions.


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Share Market Live Update: Stock market opens with red mark, pressure on Sensex-Nifty
Share Market: Today the stock market opened with a red mark. The Bombay Stock Exchange's 30-share major Sensex Sensex opened 36 points lower. At the same time, the National Stock Exchange's Nifty also opened with pressure. The Sensex opened at the level of 29505 today, which closed at 29,468.49 on Tuesday. The Nifty opened at […]Continue Reading


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Does the number of layers in a service make a difference on the performance of the server? For example, if I am serving the same data, does it make a difference if my service has 20 layers or 1500?
I have a project where we have 10 to 20 feature classes in a geodatabase, but to view them properly, we need to put query definitions on them to break it up. The resulting map can have anywhere from 900 to 1500 layers.
I have two options:
1) I can put those query definitions in an mxd and create a service out of it (1500 layers).
2) I can serve the feature classes as layers w/ no query definition (20 layers) and put the query definitions on a web app.
All things being equal, does it make a difference performance either way?


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KIRSTEN O'BRIEN started out in TV with Otis the Aardvark in the Broom Cupboard in 1996 on CBBC. She went on to host many children's TV shows including Smile and Totally Doctor Who, before moving into consumer programmes and hosting shows on TalkRADIO and BBC Berkshire. She has three children, including twins, and is a keen property renovator.
When did you buy your first home?
I was 26 when I bought my first home in Camden in London in 1998. It was a one-bed terraced Victorian ground floor/basement flat with a garden. I was working on CBBC and had been renting the flat above. One Friday afternoon, the elderly man who owned the flat downstairs knocked on my door and said he had decided to move to Mauritius. I was frustrated he hadn't come to me before engaging an estate agent as I'd always said I wanted to buy the flat.
What did you do next?
The next morning, I was on-air presenting kids' telly and in between cartoons I kept ringing the estate agents until someone picked up. They hadn't even prepared the paperwork for the property and I told them I would like to buy it for the asking price. They never did the paperwork and no one else saw the flat. It was the easiest house move ever as there was no chain.
Did you feel nervous taking on a mortgage?
I was so excited. I was a bit geeky, learning about mortgages. I remember thinking I needed to have £5,000 savings in case I came out of work. I never managed to save that much. I thought the worst that would happen if it went wrong is that I would have to sell. I got one of the promoters I worked for to write a letter to say that I was good for the money — imagine that these days.
What condition was the property in?
The flat was a state when I bought it. The elderly man had not done any repair work, so the first thing I had to do was get it deep cleaned. I then went about ripping up carpets and doing little cosmetic changes. My friend Siobhan came round and helped me pull up the stair carpet. The dust was giving me asthma but it was worth it when we exposed beautiful floorboards.
What did you like about it?
It's on a quiet road but so central, you get to the top of the road and you are at the start of Camden market. I loved getting off the Tube into the hubbub but being home two minutes later. It wasn't always quiet — we had squatters in the flat opposite and one of the neighbours protested on the roof of the community centre, leading to the street being cordoned off in a 'siege situation'. But there was a real sense of community. I still pop back to see Aftab the local newsagent when I'm in the area.
Did you do much to the flat?
I completely renovated the flat, turning it from a one-bed into a two-bed. It had a strange layout with a lounge and bathroom on the ground floor and a kitchen and bedroom in the basement. I moved the kitchen upstairs and managed to put in an extra bedroom. Years later, I added a little sun room on the back.
Did it change your life?
It was my haven after all the madness of work. I loved living alone but it was a very social house, I always had barbecues and parties. My now husband moved in with me and we had our first son there, bringing him home from hospital and putting him under the Christmas tree. It's filled with wonderful, happy memories.
Where did you go next?
I was there for 16 years before it got too small for us when our family grew. I was lucky that the flat had increased in value dramatically and it was enough for us to be able to buy a bigger home outside London. Funnily enough, we drove past yesterday and we were marvelling at the new shops and changes around Camden. It's a great place to be when you are younger and I'm so glad I got to call it home.
■ Kirsten O'Brien presents on BBC Radio Berkshire, championtalent.co.uk
All about… Camden
THE go-to place in the Noughties, this slice of North London has lost a little of its cool in the past decade. Rampant gentrification has kicked out much of the authentic Camden bohemia and the market has turned into a large souvenir shop, although the Hawley Arms and the Dublin Castle — the stomping ground of Amy Winehouse and Pete Doherty respectively — have survived. The properties are mainly Victorian houses divided into flats and studios at eye-watering prices. Last year, most property sales in Camden involved flats, which sold for on average £831,891. Terraced properties sold for an average price of £2,018,971, while semi-detached properties fetched £2,670,155 (rightmove.co.uk).


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Nestling in the heart of the beautiful Devonshire countryside this brand new development of luxurious lodges enjoys an idyllic lakeside setting, home to an abundance of wildlife and offering a haven of peace and tranquility. Situated close to Dartmoor National Park this is an excellent location for exploring the many delights this picturesque area has to offer, from the pretty village of Winkleigh to bustling Okehampton with it's castle. There are also many walks and cycle routes nearby including the Tarka Tour.
Each lodge has been beautifully designed to a high standard and offers contemporary, modern luxury interiors, ideal for a romantic getaway or family holiday at any time of year.
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The Ruby (8.53 miles)
Dartmoor Edge Lodges (15.34 miles)
Woodovis Park (16.35 miles)
Eastcott Lodges (17.40 miles)
Indio Lake (17.90 miles)
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Position: Defender, Forward. 100 babes in Australia Marshfield, Wisconsin. 010
Nationality: Canada, United States of America. Austrapia Forward.
Babee Diamond Bar, California. Nationality: United States of America.]


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What would you do with your best friend's family on a Saturday in NYC when one of the participant's is 5 years old?
2. Did you take part in the TQC xmas exchange? If so, did you get a gift? If not, go here.
3. I have 5 days off starting tomorrow, what would you do in New York City?