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Call Of Duty WW2 Release Date, Story Details
All the information regarding Call Of Duty WW2 Release Date is available along with the rumored specification and features. Call of Duty WWII is rumored to be leaked online with its data and other details. After the activision which announced on Friday, the more details about the upcoming version of the Call Of Duty WWII has come into the air.
The release of the game is marked as the November 3. Another new thing about the call of duty WWII is that they WWII will have the new story and a different plot line.
One of the game's description reads as, "Land in Normandy on D-Day and battle across Europe through iconic locations in history's most monumental war".
The reports say that the game will have the stories of the "unbreakable brotherhood of common men".
To talk about the graphics of the game, the graphics are rumored to be more strong and realistic this time. The multiplayer mode of the game is rumored to be interesting though. The multi player version of the Call Of Duty WWII will consists of maps set and most natural locations with extremely original and natural animation. It is rumored that the new version of the Call Of Duty will feature the new socially interaction features while playing multiplayer.
The co-op feature will deliver the story during the game play and make the game more interesting. Over all the Call Of Duty WWII is expected to be much exciting and adventurous which will provide a different level of arcade game experience.


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Report: St. Paul Police, Dispatchers Experiencing Serious Staffing Shortage
"Each year it gets busier and busier and busier, and 911 calls keep coming in," Chief Todd Axtel told city council members. "It's simple math: more people living here, more people visiting here, we're going to have a higher demand for police services."
Star Tribune
By Liz Sawyer
A St. Paul Police Department staffing study -- which can be reviewed in full below -- recommends hiring more than 100 additional officers and civilian staff, as well as restructuring several investigative units to keep pace with growing caseloads.
The 250-page document compiled by Cmdr. Jack Serier examined department data and statistics between 2013 and 2018, including response times and 911 calls over the six-year period. It's the first comprehensive audit of its kind in at least a decade and comes at the request of the City Council.
Among his findings, Serier emphasizes the need for increased staffing across the board. He suggests adding 78 sworn personnel, including 33 sergeants, and another 25 full-time civilian employees to fill administrative roles -- a costly request that isn't likely to receive much support from City Hall.
We're working extremely hard to meet the demands of our community," Serier said during an interview. "It's not about making a model to give you every bell and whistle you want. This is a model that adequately addresses the needs today."
The report did not include cost estimates associated with the recommendations, but Serier said each additional police officer requires approximately $90,000 to $110,000 for salary and benefits.
Most suggestions were made with efficiency in mind, Serier said. One streamlining measure would involve splintering the homicide division into four separate units. Right now, homicide detectives are stretched thin juggling murder investigations alongside aggravated assaults, shootings and kidnappings.
"Some egregious crimes assigned to the Homicide Unit cannot be properly addressed due to the frequency of homicide investigations," wrote Serier, a longtime law enforcement official and former Ramsey County sheriff.
At a time of unprecedented gun violence in the capitol city, he believes homicide detectives should be solely focused on death investigations. The department could achieve that, he said, by establishing three new units: one for cold cases, another for robberies and kidnappings, and a Violent Crimes Against Persons Unit dedicated to assaults and nonfatal shootings.
Last fall, Chief Todd Axtell reiterated a plea to City Hall for more resources to keep up with service calls.
"Each year it gets busier and busier and busier, and 911 calls keep coming in," Axtell told council members at the time. "It's simple math: more people living here, more people visiting here, we're going to have a higher demand for police services."
Between 2013 and 2018, the study shows, the number of 911 calls in St. Paul rose 31 %. In 2018, more than 5,000 high-priority 911 calls could not be dispatched within 30 seconds because not enough officers were available to respond."
But Mayor Melvin Carter's 2020 budget reduced the maximum number of sworn officers from 635 to 630, after staffing increases in both 2018 and 2019. Instead of funding more officers or gunshot-detection technology, Carter proposed an additional $1.7 million for youth employment and outreach, recreation center programs and streetscape improvements.
The department now has 608 officers on its payroll, 570 of whom are available to work, the study says, noting that the number of officers fluctuates due to retirements, vacations, military deployments and parental leave.
Serier is expected to present his findings to the City Council on Feb. 26. After that, he expects the conversation to shift back to the community.
"What kind of levels of service do we want from our police department?" he said. "And if compromises are part of that, what are willing to go without?"
(c)2020 the Star Tribune (Minneapolis)
Visit the Star Tribune (Minneapolis) at www.startribune.com
Distributed by Tribune Content Agency, LLC.
McClatchy-Tribune News Service
Organizational Study of the Saint Paul Police Department Final Report 12-08-2019 by Ed Praetorian on Scribd
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painting master creative art course - famous artists course created by 12 famous artists, ... the...
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P a g e | 1 | Famous Artists School Painting Master Creative Art Course
Painting Master Creative Art Course MASTER Creative Art Courses contain the same in-depth art instruction Famous Artists Courses have been offering for more than 60 yearsbut now available with an online edition to supplement your textbooks! Get one-on-one instruction in all the tools and techniques you need
to access the artist within you.
PAINTING MASTER Creative Art Course is the one-of-a-kind creative art course created by 12 famous artists, including the renowned Norman Rockwell and Albert Dorne.
If your goal is advancing as far as you can in painting, the PAINTING
MASTER CREATIVE ART COURSE is what you need to take you from the basics (FOUNDATIONS) all the way through mastery of using paint to express your unique creativity.
The PAINTING MASTER CREATIVE ART COURSE includes the FOUNDATIONS course with its 10 assignments with Artist/Instructor feedback and evaluation and the advanced techniques PAINTING course with its 14 Artist/Instructor feedback and evaluations.
n You will receive the course in 0nline and print delivery format, which enables you to study and work on your own time, and progress at a pace thats comfortable for you. Draw, paint, and study in your pajamas, at the corner coffee shop, in the morning or at nightits up to you. PLUS: you also receive our beautiful printed two-volume FOUNDATIONS and two-volume PAINTING textbooks when you enroll, giving you complete control over how and when you study!
n Youll receive one-on-one guidance from one of our professional Artist/Instructors who help lead you to total skill mastery. Instructors provide hand-prepared, detailed critiques of each and every assignment. This is possibly THE most unique aspect of our program and one of the most valuable! The MASTER CREATIVE ART COURSE includes 24 critiques!
P a g e | 2 | Famous Artists School Painting Master Creative Art Course
n You will be enrolled in a world-class curriculum: this extensive art course boasts an impressive 60-plus-year history; originally conceived and developed by 12 world-famous artists who believed giving student artists instruction in the fundamentals of artistic expression was like giving them the keys to the kingdom.
n You can take a look at our Free Preview: we offer a course sampler online so you can see for yourself how clear and comprehensive the lessons are, and how easy it is to follow along and stay engaged. Sign up for the preview here: http://arthomestudy.com/amember4/signup/index/c/freepreview
n You have 24/7 access to our beautiful online textbooks: FOUNDATIONS contains 10 huge chapters. You start with the very basics of pencil, charcoal, and ink, followed by watercolors and oils, and then a deeper dive into design, composition, color theory, perspective, textures, and patterns. You then progress to the advanced lessons in PAINTING, which provide instruction covering motifs (still life, portrait, landscape), creative expressions, and the technical points of anatomy and clothing. The PAINTING textbooks contain nine information-packed chapters and one chapter with all of your advanced assignments. The textbooks are filled with instructional artwork, how-tos, and tips and tricks for using your tools like the pros do.
n You will get our gorgeous printed textbooks; our full-color print editions are shipped as soon as you enroll. These textbooks, the two-volume FOUNDATIONS and the two-volume PAINTING editions, offer you the ultimate in flexibility. Want to unplug and curl up in an easy chair to study? Our textbooks provide you that comfort. Hundreds of pages of full-color instruction for each course that you keep forever. Spiral-bound binders lie flat for easy studying and reference. Youll treasure them and refer to them for years to come.
n You get our IRONCLAD MONEY BACK GUARANTEE: You have 15 days after enrolling in the course to ask for a full refund, no questions asked. We believe strongly that you will find this course incredibly valuable, but we dont want you to take it if youre not completely happy with it.
P a g e | 3 | Famous Artists School Painting Master Creative Art Course
The Curriculum: FOUNDATIONS THE BASICS Chapter 1The Basic Art Materials: Pencil and Ink Pencil drawing How to get different effects with pencil Drawing in ink with pen and brush Experiment with your pens Drawing with brush and ink Different tools, different effects
Chapter 2The Basic Art Materials: Watercolor and Oil Painting Tools for wash (transparent watercolor) painting Basics of painting in wash Demonstration: Painting still life in wash Tools for opaque (non-transparent watercolor) painting Various techniques of opaque painting Demonstration: Painting landscape in opaque Advice for watercolor painting Handling oil paint Arranging colors on your palette Mixing colors Using varied brush and knife strokes Three steps for painting in oil Painting in acrylics
Chapter 3Basic Design Design has many functions Design is everywhere Circle and square Shape in terms of viewpoint Giving variety to negative shapes Design and observation Design and imagination Composition and action Experiments in composition
Chapter 4Composition The four main elements of composition Picture area Applying common sense to composition Depth Use depth in an interesting way Design in depth Line Using line to full advantage Value Plan with a few simple values Creating a center of interest Controlling values in a composition 7 hints for composition
Chapter 5Observation and Perspective Light and dark shapes Aerial perspective Shape, value, and edge Vantage points Forms in depth Two-point perspective Drawing the circle Compound forms Reflection Great artists and perspective
Chapter 6Basics of Picture-Making: Form What is Form? How to Draw the Illusion of Form Objects Have a Basic Form Drawing the Basic Form Combining the Basic Forms Light and Shade Solid Forms Make Good Pictures Creating Realistic Forms Creating Form in Space Flat Shapes Show Form Form Drawing Step by Step Form in Perspective Arranging Forms in Space Making an Accurate Drawing
Chapter 7Reproducing Texture Creating Texture and Pattern Variety of Form is Everywhere Variety in textures Repeated Forms Texture and Mood Effect of Distance Pattern and Texture Handling Texture Applying the principles Controlling Texture Contrast in Textures Drawn Textures Contrast in Approaches Five Artists Draw an Eagle Texture Balance
P a g e | 4 | Famous Artists School Painting Master Creative Art Course
Chapter 8Effect of Color An Introduction to Color Three Dimensions of Color One Color Affects Another Color in Different Lights Advancing and Receding Colors Varied Effects of Color Using What You Have Learned Collage as a Trial Sketch
Chapter 9Drawing the Human Figure The Human Form Contour Drawing Gesture Drawing - Drawing Hands and Heads Balance Proportions Form and Bulk Modeling Weight and Bulk The Basic Forms Using the Gesture Drawing Working with a Model
Chapter 10Drawing the Head and Hands Drawing the Head Forms of the Head Basics for Drawing the Head Light and Shade on the Head Male and Female Heads Drawing Children Gallery The Expressive Hand Construction and Action Blocking in the Hand Gallery Hands in Pictures
Each Chapter contains all of the details of your Assignment, which you complete and return to the School for evaluation and critique by your Artist/Instructor.
The Curriculum: PAINTING MASTERY Chapter 1: Picture Making in Oil Enjoy painting in oil The size of your picture surface Oil painting is different from watercolor Paints, brushes a mediums Drawing with brushes or knives The basic principles of picture making The paintings of Ryuusei
Chapter 2: Painting Still Life Still lifean ideal subject Selecting your subject Composing the still life motif Control the lighting Composing a still life painting Think in simple value patterns Painting still life with cool and warm colors Color in still life Painting a still life with flowers
Chapter 3: Painting Landscape Nature is a treasure house Composing a landscape painting Creating depth and the illusion of distance Vantage affects the landscape Simple value patterns Painting buildings with warm and cool colors Color in a landscape Painting a landscape in oil Making discoveries with your heart and eye Grab your sketchbook and go outside Local scenes Painting a red brick warehouse Painting with brush and knife Gallery
Chapter 4: Painting the Human Figure The nude, the eternal subject It all begins with drawing Paint the figure using basic forms Painting the nude [seated] Painting the nude [reclining] Painting the nude [standing] Gallery What is more interesting than the human face? Composing a portrait Translate into simple value patterns Make skin color using warm and cool colors Painting a portrait in oil Painting a self portrait Painting a portrait in mixed media Gallery
P a g e | 5 | Famous Artists School Painting Master Creative Art Course
Chapter 5: Creative Expressions Two artists paint the same landscape In search of your own expression A simple composition Painting with simple patterns Creating patterns Drawing with simple lines Simplifying the forms Drawing the things around you/Kasai Gallery Using clear outlines In the style of the Impressionists Painting in layers Using the knife more often Effective impasto Texture of buildings Painting the nude Gallery Images proliferate Making good use of slides Gallery
Chapter 6: Picture Making in Watercolor The charm of watercolor Wash paint and brushes How


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Mother pus bucket!
I seem to be the only one here who couldn't give a flying fk about pvp lol
What would you have them do? Put in ranked BG's and arenas?
Sorry, but some people like me want vanilla as it was warts and all. Does it REALLY affect you if 1% of the player base grinds harder than you or has more free time and has a meaningless title? It doesn't give them legendary weapons or anything to overpower them; if anything i fear a nax geared raider with a legendary more than i do a high warlord.
Perspective and all.
There's current wow for those who don't want to commit time or energy into classic, but there's currently nowhere for fans of classic wow to go until it comes out. Don't take that away from us.
Honest question, why are we mad about keeping the grind system?
Like, why does it matter?
Are you hurt that, back in the day, you achieved rank 13/14, but in today's world you simply won't have the time?
Seems like "working as intended".
Maybe you never got that high and, with Classic coming out, you thought maybe you could?
Well, if that's the case, put in the time like everyone else.
Or are we mad that the highest titles aren't just given out to everyone like a participation trophy?
I mean, how do you change it to fit the landscape of Classic without causing even more issue?
If you can play 20 hours a day.. you should get 20 hours of results.
If you play 2 hours a week? Play BfA... they give you everything for 2 hours play a week.
Putting things like caps and gating in the game only reduce the value of playing the game, and puts the "unfairness" onto other people.
In an MMO, not everything has to be achievable by everyone.
EDIT: Actually, I'll even go so far as to say there were (statistically speaking) some people who changed their mind, but even so, that doesn't change the fact that you're talking about two (or more) different groups and their opinions on Vanilla/Classic.
Last edited by The Stormbringer; 2019-04-12 at 03:21 PM.
I'll never get the high ranks myself, but I still do not think the system needs changing. It should be what Vanilla was.
You don't personally have to do everything. Even if you want to. Enough commitment and it might happen.
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Maybe Blizzard will do that somewhere down the line, after too many players experience the system and are sick and tired of needing to grind constantly.
Smart min-maxer's will just do, what most did in vanilla. Get EZ R11 (mounts) or R12 (3 free epics) with the AV bonus weekends and just fill the rest of gear with raiding or class quests (hunters/priests).
You did not need the R14-weapon farm if you could get Lok or Anathema with even the most casual raiding groups.
If you choose the right class, the whole pvp rank system was just as easy to min-max as the current gearing with a single weekly M+10 chest.
I agree they need to have a reward system based on skill and not time spent. But how are they going to do that without ruining the "authentic vanilla experience"?
Just let the no lifers pvper have their vanilla grind.
Selfish of you to take that away from them.
Are people really complaining they'll have to play a lot and put in a lot of hours to be in the top ranks of pvp?
You mean like the top ranked PvE guilds that put in insane hours to get world first in new raids?
Did people think classic was going to be easy or something? There's a reason most things from vanilla have been changed. Personally I remember quite enjoying pvp in vanilla but I only did it for fun, not for top ranks. Is that the point? So if you don't find doing it fun, don't do it. If people do find it fun, leave them to it.
The Vanilla pvp Rank system will always be a better design then some RNG paid lootbox some games use to get some of it's content.
Just because few people at a time can get it, doesn't mean there need to be some easy alternative catering to everyone.
WoW already lead to 4 difficulties of the same raids which is a stupid direction they took too far.
TBC had epics with resilience from Arena, not exactly a brilliant alternative either.
And they also gave the titles of Vanilla away later on via Rated battlegrounds, so people can get their Grand Marshal/High Warlords in WoW right now (since Cataclysm)
Last edited by Teri; 2019-04-13 at 12:55 AM.


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Department of Hispanic and Italian Studies
Dr. T. Srivani
Associate Professor
Ms. Ira Vangipurapu
Assistant Professor
Ms. Dimpi Sharma
Assistant Professor
Ms. Aparna Nori
Assistant Professor
Ms. Surendra Singh Negi
Assistant Professor
Ms. Sandal Bharwaj(Italian)
Assistant Professor
Ms. Sheetal Mahadev Wagh
Assistant Professor
Mr. Satyajeet Prakash
Assistant Professor
Dr. Ashwani Kumar
Assistant Professor
Establishment of the Department
Spanish was introduced as a foreign language at the University in 2001. Italian was introduced in. The Department was set up in 2015 and became a part of the School of European Languages.
Responsibilities of the Department
- Conducts language and culture oriented courses leading to Post- graduate and Under-graduate degrees and Part-time Certificates
- Promotes study in the spheres of language, literature, culture of the Hispanic and Italian worlds.
- Organizes seminars, workshops, conferences, extension lecture and colloquiums.
- Prepares young professionals in the field of language for academics and industry
- Develops teaching-learning materials in print and electronic media
Programmes conducted by the Department
Full time
- M.A. Spanish
- M.A. Spanish (Distance Mode) ( 2011-14)
- B.A. – Spanish (Three Years)
Part time
- Certificate of Proficiency
- Diploma
- Advanced Diploma
- Certificate of Proficiency
- Diploma
- Advanced Diploma


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Health Professional
I think that you should discuss this with your GP.
S/he will be able to draw up a "Mental Health Care Plan" with you - that will entitle you to a number of (Medicare-subsidised) sessions with mental health professionals (a psychiatrist and/or a clinical psychologist).
All the best.
You must be a HealthShare member to report this post.to your account or now (it's free).
It sounds like you may benefit from getting an assessment done in order to find out in more detail what is going on for you and what may be helpful. As Simon has mentioned, the place to start is with your GP, who can do an initial assessment and then refer you to the right specialist help. It's hard to take that first step at the best of times, even more so when you are dealing with depressive symptoms. Good on you for reaching out and taking that step here, and good luck with your next steps.
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There were plenty of Red Carpet eye candy that either wowed the crowd or had us fashionistas asking who the heck styled these actors. But nevertheless, there were my personal favorites and one of them ranking to the top of the list was none other than, Amy Adams.
Her Marchesa pink / nude gown portrayed such elegance and class that I could not stop staring and wishing that was me wearing that exact beauty. She also dazzled in Tiffany & Co. Lucida Diamond Earrings in Platinum, Round, Pear-shape, and Marquee Cluster Bracelet in Platinum, Tiffany Victoria Diamond Alternating Bracelet set in Platinum and Tiffany Victoria Diamond Bracelet set in Platinum.
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· Next, he blended Laura Mercier Sateen Eye Colour in Sable onto the top of her lids and under her bottom lashes.
· Sollitto lined Adams' eyes using Dior Style Liner and applied Dior DiorShow Backstage Makeup Mascara to elongate her lashes.
· Sollitto applied Laura Mercier Crème Smooth Lip Colour in Plum Orchid to the star's lips, and then completed the look by applying Laura Mercier Lip Glacè in Raspberry.


text: INKOL has started its production adventure in Izmir in 2007 and continues its production in its modern facilities with 2500 m2 closed area which is currently in ITOB organized industry. Adopting high quality production at international standards, Inkol has adopted the principle of responding to the demands of the customers with its understanding of customer satisfaction. INKOL PANO, observing the deficiency of panel production in the developing electricity and automation sector and the demand is met by imports, was activated in the year 2007 in Izmir. INKOL PANO who knows the importance of domestic production for the national economy, started to announce its name rapidly in the sector by adding new products to its product range and raising its production standard. By producing wall type, vertical type, pult type and computer cabins applicable to low voltage equipments, it addresses a fairly broad area like energy distribution and management centers, factories and production areas, metallurgy and mining, airports, marinas, clever buildings, shopping malls. Its main objective is to be a solution partner to the firms who make applications in electricity and automation sector, to mmake exports by passing to modular enclosure manufacturing. RESEARCH AND DEVELOPMENT: Although INKOL PANO has newly entered the sector, it has achieveg to present 110 differnt designs to the market in a short time due to the importance it has given to Research and Development. We will also continue to add the new products observed to be missing at the consequence of the market researches we have made to our portfolio. It is closely monitoring the technology with the CNC Punch, conveyor paint furnace line, CNC hydraulic press, liquid seal pouring machine, hydraulic guillotine shears, eccentric presses, powder paint facility, phosphate facility, undergas welding, rivet center machine, insulation test instrument, grounding megger and multimeters. LOW VOLTAGE ELECTRICAL ENCLOSURES: Wall Type Enclosures: Yelken and Vira Series Standıng Type Enclosures : Sancak and Pusula Series Pult Type Enclosures : Pupa Series PC Cabins : Rota (Route) Series INKOL PANO who names itsenclosures by nautical terms, directed its route towards overseas with its high quality and meticulous work. GENERAL PRODUCT PROPERTIES: The vertical and Pult type enclosures and PC Cabins are produced as the frame and the front door being 2 mm, side, top and back iron sheets 1,5 mm and with poliurethane cast seal. And in the wall type enclosures, the sheet iron thicknesses vary between 1,2 and 1,5 mm according to their dimensions. The assembly plates are manufactured of galvanized sheet steel, and in covers and doors, DKP steel sheets are used. Since they are pre-painting surface processed and subjected to chemical protection, they show high resistance against corrosion. The entirety of our products are electrostatic powder painted. The color of our Standard products is Ral 7035. In the standıng types, the lock mechanism operates in a way to apply pressure from three points. Alsao, since poliurethane sealing technique which is the final point technology has reached, all our products are under protection against low and high pressure coming from all angles. In IP Protection Class; we are making production with 65 protection in Yelken Series , 6Read More


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Vol 18, No 3 (2015)
- Year: 2015
- Articles: 13
- URL: https://dia-endojournals.ru/dia/issue/view/609
- DOI: https://doi.org/10.14341/DM20153
The prevalence of type 2 diabetes is increasing dramatically, and the pathogenesis of the disease has been studied extensively in recent years. Of particular interest, incretins are reported to cause changes in insulin secretion that affect the natural development of the disease. The emergence of new drugs that act via the incretin axis have led many clinicians to consider their place in clinical practice.
Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data) – is one of the most actual medical challenges of modern engineering and cybernetics.
Artificial pancreas (AP) prototypes based on wearable insulin pump with subcutaneous insulin delivery are still problematic, mainly because of slow insulin pharmacokinetics. Intravenous insulin infusion via AP allows effectively maintain euglycaemia for inpatients, due to insulin pharmacokinetics and pharmacodynamics advantages. Unfortunately, it can't be used for outpatients. Intraperitoneal insulin infusion is still relatively infrequently used in the world, but it is a promising alternative, compared to both previous methods due to a physiological action profile, fast insulin pharmacokinetics, relatively better safety and availability for outpatient usage.
The purpose of this review is to describe the intraperitoneal insulin infusion features for diabetes patients at a point of AP creation perspectives.
Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.
The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.
The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).
The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c.
Recent data suggest that chronic critical limb ischaemia (CLI) is the most important reason for amputation among diabetic patients. The high prevalence of CLI in this patient group is associated with specific clinical and morphological properties of peripheral arterial disease. Percutaneous transluminal angioplasty is an appropriate primary therapy, but it is not considered early in the disease process, and is instead reserved as a limb salvage strategy. Low primary patency, despite optimal clinical effects, remains a typical issue of percutaneous transluminal angioplasty for diabetic patients in particular. Thus, the indications, technical success and clinical results of endovascular revascularisation need to be clarified in patients with diabetes. Although difficult, the procedure can be effective through a multidisciplinary approach.
To compare the clinical and morphological characteristics of chronic diabetic foot ulcers and the markers of repair.
Materials and Methods.
We included 26 patients with neuropathic diabetic foot syndrome who had signs of severe peripheral neuropathy. Biopsies were performed from the margin and central part of the lesion and were fixed in a 10% formalin solution before being placed on paraffin slides and stained with hematoxylin and eosin. We assessed the percentages of necrotic, granulation and fibrotic tissues and the severity of vascular hyalinosis. Immunohistochemistry was performed with initial antibodies to Ki-67 (a marker of proliferation), smooth muscle actin (a marker of myofibroblast synthesis) and cytokeratin (a marker of epithelisation). For analysis, the samples were divided into three groups by the length of time the ulcer had been present: group 1 (≤90 days; 9 samples), group 2 (91–365 days; 10 samples) and group 3 (>365 days; 9 samples).
The patients of group 3 were older than those of groups 1 and 2 (53.7±2.7 vs 51.7±5.9 vs 59.9±5.6 years; p=0.04). There were no differences in the duration of diabetes, glycated haemoglobin or severity of neuropathy. The percentage of necrotic tissue was higher in group 1 (33.7%±21.7% vs 11.0%±3.9% vs 12.8%±6.1%; p=0.02) and the percentage of fibrotic tissue was highest in group 3 (21.1%±21.0% vs 35.5%±19.8% vs 54.4%±23.9%; p=0.001). However, the amount of granulation tissue was not different between the groups (45.2%±21.1% vs 53.5%±21.1% vs 32.8%±26.3%; p=0.4). There was also no difference in the severity of vascular hyalinosis between the groups (p=0.9). Expression of Ki-67 was higher in groups 1 and 2, implying a greater capacity to regenerate. The expression of smooth muscle actin and cytokeratin was higher in groups 1 and 2 but without statistical significance.
The morphological characteristics and regenerative capacities of neuropathic diabetic foot ulcers differ with the duration the ulcer has been present. Patients with ulcers for less than 1 year were characterised by higher cell proliferation but lower fibrosis. Neuropathic diabetic foot ulcers that are unable to heal over a year are characterised by incomplete regeneration and higher levels of fibrosis. Thus, different treatment approaches are needed depending on how long an ulcer has been present.
To study at greater than before material the prevalence of type 2 diabetes (T2DM) in relatives of suffering from T2DM patients with cancer and compare the features of antidiabetic therapy in cancer patients with a familial and non-familial form of diabetes.
Materials and Methods.
Information about diabetes history in family was collected during two subsequent periods (May 2009-February 2011 and March 2011-July 2014 years) in cancer patients (totally,1955 people; 1351 of them with T2DM and 604 without diabetes), as well as in patients with T2DM without cancer (n=379). All patients answered questions about diabetes in their mothers, fathers, siblings, and other relatives. In cancer patients with T2DM, data on the type of antidiabetic therapy for at least 6 months prior to enrolling into the hospital were collected.
A lower frequency of family diabetes in diabetic patients with cancer (28,5±1,2% vs 38,0±2,5%, p<0.01 in T2DM without cancer) was revealed. By 2011–2014 the prevalence of family diabetes was grown significantly and virtually in a similar degree in both groups (+17,9% in 'T2DM with cancer' and +19,3% in 'T2DM without cancer'). T2DM patients with cancer and family history of diabetes used metformin prior hospitalization more often than same patients without familial T2DM.
Reaffirming the earlier data on more infrequent occurrence of family diabetes in T2DM patients with cancer compared with T2DM patients without cancer, we were able to demonstrate roughly the same increase in the detection of familial diabetes in these groups of patients in a rather short period of time. The use of metformin – one of the potential factors contributing to the probable and unexpected decrease of cancer risk in T2DM patients with familial type of diabetes. Other possible causes of this phenomenon deserve further study in view of the growing epidemic of diabetes and obesity.
To evaluate the influence of combined therapy of sitagliptin and metformin on fat metabolism in patients with type 2 diabetes mellitus.
The study included 82 patients (age, 55.3±9.1 years) with obesity and lipid metabolism disorders. None of the patients had reached their target glycated haemoglobin levels after metformin and diet therapy. Patients in group 1 (n=42) received 1.5–2-g metformin daily before the study and were switched to a formulation of 100-mg sitagliptin and 2-g metformin once a day. Patients in group 2 (n=40) were on a diet therapy before inclusion and were started on 2-g metformin/day. The following were evaluated at baseline and after 6 months of therapy: fasting glucose levels, postprandial glucose levels, glycated haemoglobin, weight, body mass index, waist circumference and lipid profile; insulin, proinsulin, leptin and adiponectin levels; insulin resistance using the homeostatic model assessment (HOMA) of β-cell function (HOMA-β) and insulin resistance (HOMA-IR). In addition, magnetic resonance imaging was performed to assess the amount of visceral fat for the total cohort.
After 6 months, glycated haemoglobin decreased by 18.52% (p <0.001) in group 1 and by 8.17% (p <0.001) in group 2. Fasting plasma glucose and postprandial glucose levels in group 1 were reduced by 21% (p <0.001) and 26.35% (p <0.001), respectively; the corresponding reductions in group 2 were 1.45% (p >0.05) and 5.31% (p <0.05), respectively. HOMA-β increased by 33% in group 1 (p <0.001) and by 11% in group 2 (p >0.05). Adiponectin levels increased by 27.06% (p <0.001) in group 1 and by 7.16% in group 2 (p <0.001). Leptin levels were reduced by 30.47% (p <0.001) in group 1 and by 5.41% in group 2 (p <0.001). Magnetic resonance imaging showed a 7.52% reduction in visceral fat for group 1 (p <0.001) and a 1.76% reduction for group 2 (p <0.01). The comparison of subcutaneous fat dynamics did not show statistically significant differences between the groups.
Compared with metformin monotherapy, sitagliptin and metformin combination therapy had a prominent effect on non-glycaemic parameters, with more marked decreases in visceral fat and leptin and increases in adiponectin levels.
Retrograde ejaculation in patients with type 1 diabetes mellitus is a complication of autonomic neuropathy that causes excretory infertility. It can be partial (reduction of ejaculate) or total (absence of ejaculate) and occurs in 10%–20% of men with type 1 diabetes mellitus.
The aim of the study was to assess the effectiveness of a new endoscopic method for retrograde ejaculation correction and antegrade ejaculation restoration.
Materials and methods.
We included 30 patients with type 1 diabetes mellitus who had spermatozoa present in their post-orgasmic urine and ultrasonographic evidence of impaired or absent bladder neck closure. The mean age of participants was 32 (30–35) years, mean duration of diabetes was 17 (12–22) years and mean preoperative glycated haemoglobin level was 7.4% (6.9%–8.0%). All participants had total retrograde ejaculation. We used conventional irrigated urethrocystoscopy under local anaesthesia. During urethroscopy, bladder neck gaping was observed in all cases. Biocompatible material was injected at three points under the mucous layer of the posterior urethra, reaching the closing of the opposite edges of the urethra. A spermiogram was examined 1 week after the operation.
Restoration of antegrade ejaculation was achieved for 22 patients (73%), and the effects persisted for a mean of 7 (2–12) months. The spouses of four men became pregnant after surgery. In one case, the pregnancy resulted in a spontaneous abortion at gestational week 8, but the other three cases continued normally.
This new method provides a highly effective means of restoring the physiological passage of the ejaculate. The operation is a low-invasive endoscopic procedure that does not disrupt urination, and it is possible to receive ejaculate of sufficient.
Metabolic syndrome (MS) is extremely common (20%–25% of the world's population), and its diagnostic criteria are defined and well known. It has been shown that patients who have MS are twice as likely to die from a cardiovascular complication and three times as likely to suffer from it compared with patients without MS. However, the underlying cause of MS remains to be clearly elucidated, although inherited factors, such as insulin resistance (IR), and external factors are considered to play a key role in this process. Special attention should be paid to MS in young patients, who may present the first manifestation of inherited lipodystrophy. The study describes the first known family in Russia (three clinical cases) with familial partial lipodystrophy (FPLD) type 3 caused by heterozygous p.R212Q PPARG mutation (MIM#601487). The study reports rare forms of inherited IR, such as FPLD, and contributes to a better understanding of common disorders such as MS.
110 years ago was born famous scientist, talented teacher and doctor, organizer of public health, honoured worker of science of RSFSR, doctor of medicine, professor Ekaterina Alekseevna Vasyukova. Ekaterina Alekseevna had long and difficult career path - from research assistant to the director of the All-Russian Institute of Experimental Endocrinology(now Endocrinology Research Centre), was head of it for 10 years, a long time was head of the Department of Endocrinology at the Central Institute of Advanced Medical Ministry of Health (now the Academy of Postgraduate Education). She had more than 200 publications, including 14 monographs, collections and algorithms in endocrinology. Under her leadershipthere were defended 16 doctoral and 63 master's theses. The main areas of her research were the methods of diagnostics and treatment of diabetes, Cushing's disease, thyroid diseases, abnormalities of reproductive growth. In 1971 she had identified the current trends in the nativeclinical endocrinology, which were the relationship between the central nervous system and the endocrine glands; immunopathology in endocrinology; study of the prevalence and prevention of diabetes. EkaterinaAlekseevnawassensitive person, a great clinician, a professional teacher. She had great authority and respect among the medical community of our country and abroad.
From July 5 to July 9, 2015 in Convention Center in Boston (USA) there took place anniversary 75th session of the annual congress of the American Diabetic Association (ADA). The congress united more than 14000 participants from 124 countries. Programs of scientific sessions of the congress included the most topical issues of diabetology: modern approaches to diagnostics, prevention and treatment of DM and its complications, the results of the international researches of anti-diabetic preparations, problems connected with diabetes 2 types and obesity and many others.


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By: Elliott Smith
A recent report from the CBC highlights what Canadian entrepreneurs have long known: things cost more in Canada.
According to the CBC:
Canadians are paying far more than Americans for the same products because of a systemic and unjustifiable markup scheme by many manufacturers, a retail expert says.
A Marketplace report on Canada-U.S. price gaps found Canadians paying higher prices — more than double in some cases — for the same retail goods because of an industry phenomenon called "country pricing." (Read the full article here)
Frustrating as this is, it's a known issue to most Canadian business owners. It's why many Canadian business leaders choose to make large purchases in the United States. And, it's why UCanTrade offers cross-border cross-docking to reduce the costs of making equipment and inventory acquisitions south of the border.
Canadian entrepreneurs can achieve substantial savings by making their large purchases in the United States, and taking advantage of the lower cost of merchandise stateside. UCanTrade can help realize the full benefit of these savings by offering cross-docking services for BC companies to take advantage of free or reduced shipping rates offered by American suppliers.
UCanTrade, Inc. president Jim Pettinger has been in the cross-border warehousing and logistics business for almost three decades, and he's seen the shift towards increased US purchasing by Canadian businesses. According to Pettinger, "More Canadian companies are now looking at more and more purchases in the U.S. In some cases, U.S. suppliers provide free shipping to a U.S. address. In other cases Canadian companies want to consolidate several small shipments into a larger one to minimize customs clearance costs. This is where UCanTrade can step in and provide cross docking services and work in conjunction with our client's Canadian Customs Broker to expedite this process at a low cost."
Pettinger adds that recently, UCanTrade was able to help a Vancouver, BC-based company save money on shipping costs with cross-docking services for a major acquisition of industrial equipment. UCanTrade's client purchased a quantity from an American supplier, a supplier that offered free delivery to a U.S. address, but charged steep rates for international delivery to Canada. From our 20,000 square foot warehouse in Ferndale, Washington, we were able to receive the shipment on behalf of the Canadian client, and hold the equipment until a truck was sent down from British Columbia to pick them up. Our client was able to utilize our facility to cross-dock and take advantage of a supplier's offer of free shipping to a U.S. address, dramatically reducing the cost of their equipment purchase.
Country pricing is a frustrating fact of life in Canada. But savvy Canadian businesses can get the upper hand by making purchases in the United States, and working with UCT to cross-dock and take advantage of favorable domestic shipping rates. Call UCanTrade today to find out how our expertise in cross-border cross-docking can help your British Columbia business fight back against "country pricing" and protect your bottom line.
TradeTips blog is published by UCanTrade, Inc., your cross-border experts since 1984.
Subscribe to our TradeTips Newsletter for the latest import/export events and trade news, and/or call us at (360) 380-6900.
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Working Paper
Narrative Sign Restrictions for SVARs
We identify structural vector autoregressions using narrative sign restrictions. Narrative sign restrictions constrain the structural shocks and/or the historical decomposition around key historical events, ensuring that they agree with the established narrative account of these episodes. Using models of the oil market and monetary policy, we show that narrative sign restrictions tend to be highly informative. Even a single narrative sign restriction may dramatically sharpen and even change the inference of SVARs originally identified via traditional sign restrictions. Our approach combines ...


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Recently, more and more poisoning accidents associated with toxic heavy metals have been reported throughout China, coal-fired power plants (CFPPs) sector is regarded as one of the most important source categories of anthropogenic atmospheric releases of heavy metals due to tremendous annual coal consumption (about 1785.3 Mt in 2012).
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text: Proposed Meeting Dates Please wait for email confirmation on the 2020 meetings. Due to the CoVid-19 pandemic, the meeting date roster may be different. These are the planned meeting times for this year. Any given meeting may be changed. For up to date information go to Calendars - Other Bookings


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Gamaliel enjoys spending time with his family, learning about new technologies and cycling. He is married and has two Daughters. He is always ready to help.


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Tuesday, December 3, 2019
Works have begun to upgrade the Destructor Pavilion at Spring Street, Sandringham. This aligns with Council's Sportsground Pavilion Improvement Plan to upgrade Bayside's sport pavilions to provide female-friendly facilities and meet the identified needs of users.
The sports pavilion will be extended to provide additional changerooms, umpires facilities and a public toilet. It is expected that the extension will be completed by mid-2020. Following the completion of the building, the pavilion closest to Spring Street will be demolished and the area returned to open space.
Residents may experience a level of inconvenience throughout the construction period including some increased traffic in the area with construction vehicles entering and leaving the site. Noise and dust will be managed by the contractor. The playground and sportsgrounds will remain open throughout the construction period.
The cost of this project is $1.5m and is one of 11 pavilions to be upgraded between now and the end of 2024.


text:
Arrmet presents at Salone del Mobile.Milano the new chair designed by Tomoya Tabuchi, fusionf italian know how and Japanese culture
The Kiyumi seating collection has a sinuous structure in black painted tubular steel. On this frame are fitted the seat and curved back, in ash veneered plywood – in five colours – or upholstered in fabric or leather. Even in the upholstered version the frame, aesthetic before being functional, remains visible. Sleek and essential, Kiyumi conceals a complex construction design that makes the screws connecting back and frame invisible, for an impeccably clean line. The collection includes chairs, armchairs and stools. Versatile, light and stackable, this seating fits into many contexts, from the home to contract environments such as bars and restaurants, where its style and excellent construction shine.


text:
New Hanover County is re-opening the bid period and is accepting sealed bids for the Mason Inlet Maintenance Project 2019\2020.
The base bid work includes hydraulic dredging of approximately 375,000 cubic yards of shoaled material from Mason Inlet, Mason Creek, and the AIWW, with subsequent placement on the southern beachfront of Figure "8" Island. An additional 75,000 cubic yards of dredging seaward of the Colregs line is also included as an optional bid item, should the Contractor have equipment capable of performing this work. Bidding on the optional work is not required. The work also consists of grading the beach and monitoring environmental concerns.
Bid documents in Portable Document Format (.pdf) are available on the County website by clicking the "Download Full Document" button at the top of this post or may be acquired from Gahagan & Bryant Associates of NC, PLLC, Chris Marello, (910) 313-3338, email@example.com. Complete sets of Bid Documents must be used in preparing Bids. New Hanover County assumes no responsibility for errors or misrepresentations resulting from the use of incomplete sets of Bid Documents. A pre-bid conference was held on Thursday October 3, 2019 at 1:00 p.m. at the offices of Gahagan & Bryant Associates of NC, PLLC located at 295-A North Green Meadows Drive, Wilmington, NC, 28405. Attendance was not mandatory.
All sealed Bids must be delivered or mailed to:
New Hanover County
Attn: Layton Bedsole, Shore Protection Coordinator
230 Government Center Drive, Suite 160, Wilmington, NC 28403
Time is of the essence and any bid received after Monday October 28, 2019 at 3:00 PM (local time), whether by mail or otherwise, will be returned unopened. Bids shall be placed in a sealed envelope, marked in the lower left-hand corner with the project title, date, and hour bids are schedule to be received. Bidders are responsible for ensuring that their Bid is stamped by County personnel by the deadline indicated. Furthermore, the County reserves the right to reject any and all bids or to waive any and all technicalities or informalities.
Bids shall be publicly opened and read on October 28, 2019 at 3:00pm in the New Hanover County Government Complex, Suite 601-Lucy Harrell Conference Room, 230 Government Center Drive, Wilmington, NC 28403.
ENVELOPES CONTAINING BIDS MUST BE IDENTIFIED AS "Bid for Mason Inlet Maintenance Project 2019/2020". Bids shall be accompanied by a certified check, cashier's check, U.S. Postal Money Order, or Bid Bond in an amount not less than 5% of Bid.
All bidders must be pre-qualified for bidding on New Hanover County capital improvement projects. Pre-bid Qualification and Reference forms can be found on the County's website: http://legalinsurance.nhcgov.com/contractors-approved-for-bidding/.


text:
Scientists Have Discovered A Treatment That Can Destroy Breast Cancer Tumors In 11 Days Without Chemos
The most common cause of cancer among women is breast cancer where 1 out of 8 women
1A big breakthrough has just been achieved by European scientists
The possible breakthrough for breast cancer by European scientists will have one huge advantage and that is the elimination of chemotherapy which takes a huge toll on many patients. The new breast cancer therapy has been termed as staggering by many as it is the first time the disease has responded to a drug so positively.
2The new multidrug therapy could destroy tumors as large as 3 cm
The new therapy had undergone trials that included women suffering from the most aggressive forms of breast cancer which
4The research studied two standalone breast cancer drugs
The research studied the effects of two particular drugs called Herceptin and Tykerb. These are two common cancer drugs but till
5How the drugs work
Both drugs work by blocking growth signals that are found between cancer cells in the body which are responsible for cell death known as apoptosis. In the first part if the study, 130 women took part who


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Everything posted by philyyy
Councils have to follow so many silly recruitment rules otherwise it might make sense to keep it in house. How does a private company really manage it more cheaply? Minimum wage? Terrifying. Good work. I do one with a group once per month and there are The Sheffield Litter Picker pages on Facebook and twitter. A cleaner city is worth more than the money. Picking it up is a constant cycle, education needs to be paid for before that. Although I have no idea why some people would need educating to take their rubbish home rather than polluting the place.
I tried but I don't think she is cut out as a venue reviewer. "It was quite nicely done out, Big range of gin. No idea on other drinks".
My girlfriend went on Friday night and said it was rather pleasant. I didn;t get much more info but can ask if you care.
Shop next to Graze Inn, Eccy road
philyyy replied to Piggybibble's topic in Sheffield News & DiscussionsMore pubs the merrier.
Anyone else ever heard of @helpsheffield on twitter ?
philyyy replied to AmberLeaf's topic in Sheffield News & DiscussionsOk. Is this a warning? Are you going to elaborate or is that all for this thread?
Anyone else ever heard of @helpsheffield on twitter ?
philyyy replied to AmberLeaf's topic in Sheffield News & DiscussionsYes, what makes you ask?
Designer clothing shops Sheffield
philyyy replied to ShannonHardy's topic in Sheffield News & DiscussionsSomeone has just said on Twitter, a place called Orange on Hickmott Road. 10 Hickmott Road Sheffield S11 8QF
The best Gluten free places in sheffield!
philyyy replied to hcotterill's topic in Going out in SheffieldNo, not that. OP - Following this post I asked on Twitter if any gluten free types would like to get together and do a gluten free pub crawl. It seemed like a fairly popular idea. Two people from the group are hoping to log the GF pubs and create a group. Do you want to join in? Probably in the new year.
The best Gluten free places in sheffield!
philyyy replied to hcotterill's topic in Going out in SheffieldOn draft - BrewDog and The Devonshire Cat. Devonshire Cat has lots and lots of bottled stuff too. The landlady is coeliac so happy to help, they also make their foodstuff too. Bottles - The Broadfield, The Beer Engine amongst others which are currently failing me.
Recycling sites
philyyy replied to dgm621's topic in Sheffield News & DiscussionsIf you have an iPhone/iPad try the Recycle Sheffield app @SheffRecycling
Council: electricity provider?
philyyy replied to Anna B's topic in Sheffield News & DiscussionsWhere is this place? Who is the councillor? Could it be crowdfunded?
Dockless bike sharing scheme to launch in Sheffield
philyyy replied to WalkleyIan's topic in Sheffield News & DiscussionsGood plan.
Wild ring necked parakeet's in sheffield ??
philyyy replied to craigmason's topic in Sheffield News & DiscussionsIs that legal?
Christmas Party for the Elderly
philyyy posted a topic in Sheffield News & DiscussionsA friend of mine is setting up her third annual Christmas party for the elderly. If anyone would like to help either financially, volunteering on the day, donating raffle prizes or Christmas decorations etc please do get in touch. Hopefully this will let me link the fundraising page but it's not just financial help that is needed. https://gogetfunding.com/the-better-together-christmas-party-2017/ ---------- Post added 27-10-2017 at 11:56 ---------- If anyone is interested we are having a fundraising night at Laycock Sports, Woodseats, S8 0JZ on Wednesday the 15th of November from 7.30pm. We will have a pub quiz with some decengt prizes, pie and peas and options to buy raffle tickets (With a top prize of £250). Tickets can be purchased for £8 each in advance using the link above with all proceeds going towards the elderly folks' party. If you use the link above for the Pub Quiz please put a note on stating PUB QUIZ and ATTENDEES NAMES. Alternatively it will be £10 on the door on the night.
That's some seriously fast walking. In fact people do sponsored runs more slowly than that.
Pigeons on The Moor
philyyy replied to Puggie's topic in Sheffield News & DiscussionsThese people need to see their doctor, "defecating pigeons" sounds unnantural and very painful.
"Friends of Parson Cross Park"
philyyy replied to Leela May's topic in Sheffield News & DiscussionsIt seems someone had been making plans https://sheffield.citizenspace.com/performance-research/parson-cross-park-public-consultation/ Speak to the people at the library. If you do get one up and running then have chat to Jade Blair via the Sheffield Litter Pickers group on Facebook as she has been organising those so is seemingly community minded.
Buck Wood - Gleadless Valley
philyyy replied to Runningman's topic in Sheffield News & DiscussionsI'm not sure there is a practical answer in the short term. In the long term it has to be education but that could take centuries. I currently report, almost, everything to the council via the Fix My Street App as well as being part of Sheffield Litter Pickers (ON Facebook and Twitter) to try and do our bit to sort it. I realise my actions are p****** in the wind but makes me feel better and keeps the gaff tidy for a while.
Boxing Gyms in Sheffield
philyyy replied to Matteyre94's topic in Sheffield Sport & ActivitiesRyan Rhodes' gym closed after about six months but relocated in S3 https://www.26rrfitness.co.uk/#
Tramlines Festival 2017
philyyy replied to Unitedite's topic in All Other EventsTo OP. I will be out and about all weekend, taking in as much as I can, whatever and wherever that mey be. It is the best weekend of the year in the city and the fact that so many local people don't buy into it is baffling to me. I will be watching The Libertines, The Big Moon, Estrons, The SSS, John Joseph Brill, Jerry Williams, Spit and Strings and Humble Williams amongst many others. Enjoy. The rain won't stop anyone (apart from sugar man above).
Does anyone know where I can find Gazebo weights today??
philyyy replied to Sony's topic in Sheffield News & DiscussionsCan't you just use bags of sand or similar? Or road grit if you need something easily accesible.
Ideas For Fundraising
philyyy replied to Queenie30's topic in General DiscussionsFacebook, Twitter, local press, ask businesses, do sponsored events, set up your own sponsored events and ask other people to attend and contribute.
Places to take kids in holidays
philyyy replied to Peaches79's topic in Going out in SheffieldHave a look on the listsings of https://littlesheffield.org.uk/ or for younger kids http://tripswithatot.com/
The character of Sheffield people
philyyy replied to daducky88's topic in Sheffield News & DiscussionsRotherham folk also call it us. Agreed but I do believe there is a slow realisation that people need to do things, regardless of the scale, themselves and try to circumvent the council and others with their slow moving, insular, obscure ways. He's got a point.
Page Hall - Rubbish
philyyy replied to samsung63's topic in Sheffield News & DiscussionsEven better and fewer excuses than I thought. Not sure what percentage of Page Hall is council or Housing Association as opposed to private. Not got time to search at the moment.