text:
Fossil is a recognized name in the smartwatch industry and has launched new smartwatches in India starting at ₹19,995/-. Fossil Gen 4 smartwatch Venture HR is a beautiful wearable with accurate activity tracking capabilities. It lets you personalize your dial; track your activities, heart rate and more. Here are the complete details:
Design and Processor
Fossil Gen 4 Smartwatch Venture HR features a stunning touchscreen digital display and a beautiful design. Also, it comes with interchangeable straps and bracelets. You can customize the buttons to control music, check date etc. This gives you the convenience of assigning the functions that you use the most. It is powered by Qualcomm Snapdragon Wear 2100 and run Google WearOS.
Activity and Heart Rate Tracking
Now easily keep track of your steps taken, distance traveled and calories burned with this gorgeous smartwatch. The Fossil smartwatch automatically tracks your heart rate across multiple types of workouts using Google Fit. The heart rate graphs show the progress throughout the workouts. Thanks to the swim proof feature, one can track swim workouts as well.
Gen 4 Smartwatch Venture HR is compatible with smartphones running Android 4.4 and above or iOS 9.3 and above. You can also use the untethered GPS to track the run distance on your watch. It automatically syncs to your mobile and keeps track on your activities.
With this smartwatch, you also get notifications for your emails, texts, app alerts, alarm clocks, calendar alerts and more.
A quick look at specifications of Gen 4 Smartwatch Venture HR:
What are your views about Fossil Gen 4 Smartwatch Venture HR? Let us know in the comments section below.


text:
"We're the bridge across forever,
arching above the sea,
adventuring for our pleasure,
living mysteries for the fun of it,
choosing disasters triumphs challenges impossible odds,
testing ourselves over and again,
learning love and love and love!"
Richard Bach
TODAY: Summer has arrived! How glorious that feels, if only for one day! What a day – what a weekend this will be, both here in Glastonbury and globally. Solar Flares, the Goodwill Full Moon, Great Invocation Day and a hot sunshine day here…Let us pray for humanity as we recite The Great Invocation…let us stir hearts and minds today! Let us each anchor Divine Love directly into the Heart of the Earth…
ONE WORD: Change
COLOUR OF THE DAY: Lady Moon (essence) Blue
HOW I FEEL: "Periodically in history the ground of man's mind is plowed under,
everything apparently uprooted into uncertainty.
How else shall the old habits of thought be broken up
to clear the way for a new epoch?"
Joseph Sadony
Sigh…I and many others, have spoken often of Divine Timing, of our life paths, where we find ourselves, the changing, the moving, working at releasing and letting go of the past and what is truly over.
To me, it feels as if we really and truly are preparing for a massive new chapter! I sense a new aligned with the Divine Plan…Yet, it also feels like a time of waiting…to allow humanity time to catch its breath, as we settle into and accept where we are going to…
PHYSICALLY: Stronger, energised yet tired.
INSIGHTS: This 'message' came to me: "The Bridge shows YOU how to live your truth, to stop hiding from what matters, what you care about, what you love, what you long for, what lights your fire, what is you, and know who are you…Your old fear of being exposed…your fear of letting 'them' go.
Trust and learn to feel the support with this movement forward…this 'crossing…'Its time…time to cross the bridge into tomorrow with no regrets, owning all that you secretly hide about who you are…Let yourself shine true!"
"You will begin to exude Light, as you begin embrace and accept YOURSELF then rung by rung, climb over and up to your rightful place as Queen/King of your road. Suddenly it no longer feels like a bridge too far…"
THE COLLECTIVE: We are all beginning again, moving to new places, new relationships, leaving the old behind…Its done! We are ready for whatever it is we are designed for…it was all arranged so very long ago…………….
AFFIRMATION: "Let light and love return to Earth…"
"Symbols act as a bridge between the inner and the outer world,
allowing the energy and meaning of the inner to flow into the outer"
Llewellyn Vaughan-Lee
My June Newsletter – SATORI is on: http://www.alorahsnewsletter.com

subset: commoncrawl


text:
Village of Minster, Ohio © 2020
- firstname.lastname@example.com
- phone: (419) 628-3497
- fax: (419) 628-1037
Website by: Midnet Media
Join Heather and learn the benefits of Castile Soap and making your own cleaning supplies. Friends of the Library will provide your first project. Additional projects available for a small fee.
Projects Include: Tub Scrub; All Purpose Cleaner; Window Cleaner; Homemade Face Wash
Click here to register.


text:
Rudrakshala Ramalinga Satyanarayana puttindi West Godavari lo unna Vemavaram lo. Satyanarayana puttindi chala poor family lo, father handloom profession chesevaru. Athanu kuda handloom ne nammukuni bratukutunnaru.
Satyanarayana ki desham ante prema deshaniki putti perigina deshaniki edaina cheyalanedi iyana korika. Ala athanu maggam vesthunapudu vacchina alochane ee unique National Flag.
General ga oka saree or dress material cheyali ante different clothes and materials use cheyali. But ala kakunda only single cloth use chesi handloom material cheyadam anedi chala time taken and difficult to do so.
It took 4 years and 6.5 Lakhs expenditure and he even sold his own house to do so.
Kani 'Ramalinga Satyanarayana' garu ivi anni pakkana petti four years back ee flag-work start chesaru. First 4×6 feet flag chesadu but adi Redfort mida host chesthe chala chinnaga untundi ani teliyadam tho adi apesadu.
Next BJP MP Gokaraju Gangaraju and YSRCP Leader Sri Ranganatha Raju help tisukuni 8×12 feet long flag tayaru chesadu. Ee four years lo 2400 tri-color threads ni Paisani style handloom work tho neyadam start chesaru. And ee flag lo madhyalo unde 'Ashoka Chakra' lo 24 spokes entha height lo unna clear ga visible ga highlight aiyye vidhanga design chesaru.
Ila without stitches and joints tho almost four years spent chesi unique handwoven handloom flag design chesaru Ramalinga Satyanarayana' garu.
Now his wish is to have it unfurled by PM at the Redfort on Independence Day.
MP and local leader support tisukuni and last k tana sontha intini kuda takattu petukuni ee flag ni chesina Satyanarayana tana wish entante ee flag Independence roju PM host chesthe chudalani undani cheppadu.
And also handloom weavers ki state and central governments kuda weavers efforts gurtinchi support cheyali ani antunnadu. Let's share this news so that his dream may come true.


text: In Three's again hehe July 26, 2013droppingmybundles I really love this little cardigan so I made another 😛 again haha This is using the amazing worsted weight yarn in the colourway pale rocks on the ocean from Never Ending Obsessions. It fits him perfectly. I adore it so much. In Three's Share this:TwitterFacebookPinterestEmailLike this:Like Loading... Related


text:
With the move towards fuller eyebrows in the fashion world, many women now want to have those brows that actress Lily Collins is famous for. There is no need to pluck your eyebrows into thin lines the way everyone did back in the 90s, now thicker eyebrows are the way to go. This is where microblading comes in. Some people still get their eyebrows tattooed on but it tends to look a bit on the fake side rather than full and luscious.
What Is Microblading?
Microblading has become the answer for women who want that full brow look but don't have thick eyebrows themselves. It is similar to tattooing in that pigment is used to fill-in pre-existing eyebrows but different in that the procedure itself does not last as long and is not done in the same manner that tattooing is. A professional esthetician who is certified in microblading will look at your brows and determine where pigment needs to be placed in eyebrow hair-fine lines to achieve that full eyebrow look which is so on-trend at the moment. A small amount of pigment will be placed under your skin but it is not permanent the way a tattoo is. The pigment will fade over the course of a year or two and will need to be redone if you want to maintain your new brows.
Choose Your Esthetician Wisely
Your eyebrows are something that is easily noticeable as they sit smack dab in the center of your face. You will want to do your research before you make your way to an esthetician for some new brows. As microblading does involve the use of needles to administer the pigment you will want to go to a properly trained esthetician that has been doing this technique for awhile. This is not a fast procedure as your esthetician will take their time as they apply pigment in thin lines in between your existing eyebrow hairs to achieve that natural look. You may find yourself at the salon for around 2 hours. It is not known to be that painful but you may feel some mild discomfort.
Taking Care Of Your New Brows
Just like a normal cut would your eyebrows may scab a bit and will take about a week to heal. Once they have healed the pigment should fade to your normal hair color if it appears quite dark at first. Then all you need to do is gently wash them with some sensitive soap, avoid touching them, and don't moisturize them that often. Essentially, just treat them as you would a tattoo, minus the excessive moisturizing.
Your new brows will be picture perfect in no time, and you will be thrilled with the results we're sure.


text:
Fixed it. TCP Optimizer did the magic, may connection speed there was set to 14Mb and after changing it to 100Mb it goes fine.
Still I am still thinking about upgrading to win10, especially with the new BASH stuff.
Thanks to everyone for posts speeds and tips, it really helped me to workout where the problem was.
in that case, it sounds exactly as i pointed to. Your TCP window scaling settings were tinkered with and was causing issues.
Glad you fixed it, looking much better!


text:
Two decades ago, millions of Eastern Europeans greeted the fall of the Soviet Union with relief and optimism. But Galina and Grigory Bobarykina, married parents of two who were living in Belarus, found little to celebrate.
Supermarket shelves were empty. The currency collapsed. In the absence of government, armed gangs and bandits controlled the highway from Moscow to Minsk, robbing travelers at arbitrary checkpoints. Rumors of pogroms — spasms of anti-Semitic violence — proliferated. And the Bobarykinas and their twin sons, Alexsandr and Sergey, could not hide their Jewish heritage because it was stamped on their documents.
Ms. Bobarykina, 68, an engineer who designed watches, said she had been repeatedly denied promotions because of her religion and was harassed by neighbors who told her to "go to your country — Israel."
She decided it was a good time to move the family to the United States, specifically to Brighton Beach, Brooklyn, where Mr. Bobarykina's sister lived. When they arrived in 1994, the family squeezed into a one-bedroom apartment, where they stayed for five years.
Alexsandr and Sergey graduated from City University colleges. Alexsandr now works in banking, and Sergey for the Internal Revenue Service.
Leaving Belarus has prolonged Mr. Bobarykina's life. His diabetes, which he had developed before emigrating, worsened in America and prevented him from working; in Belarus he had been an automotive engineer. His kidneys eventually stopped functioning. Mr. Bobarykina, now 71, applied for Medicaid, and the health care he received in America was far superior to what he would have gotten in his homeland, he said.
Because he saw doctors so often — he has had four hours of dialysis three days a week for 10 years — prostate cancer was detected at an early stage. Five years ago, when doctors found a heart problem, Mr. Bobarykina received a pacemaker.
Ms. Bobarykina, who met her husband shortly after college, when her best friend married his, cannot discuss her husband's diagnosis, end-stage renal disease, without crying.
"Depression," she said in her fragile English. Most of her life is spent with doctors, and she cannot work because she must care for her husband. The stress, she believes, triggered her hyperthyroidism. One thing that cheers her up are her daily visits with her grandchildren — ages 8 months, 1 and 3 ½ — who live nearby.
In June, a hospital social worker visited the Bobarykinas in their one-bedroom apartment near the Belt Parkway in Sheepshead Bay and noticed the air-conditioner was not working; they had been relying on a floor fan for a year. Mr. Bobarykina, who rarely leaves the house, grew sicker as the temperature rose. Ms. Bobarykina was referred to Catholic Charities Brooklyn and Queens, one of the seven beneficiary agencies of The New York Times Neediest Cases Fund, which provided $330 for a new air-conditioner.
The Bobarykinas still live on a limited income that includes Social Security, food stamps and a federal rent subsidy, and Ms. Bobarykina visits a Catholic Charities food pantry in Coney Island once every two months to stock her kitchen. She would go more often, she said, but because of budget cuts, coupled with a surge in demand — more Americans are receiving food aid than ever before, according to the United States Department of Agriculture — the charity has had to cut back on what it can provide.
The Bobarykinas are still a couple in love. When he was asked what first attracted him to his wife, Mr. Bobarykina he did not hesitate to answer.
"Smile," he said.
"And eyes," his wife chimed in.
At first glance, Mr. Bobarykina does not appear ill. That is because giving up is not an option, he said. He has a goal.
"I want to dance at my grandchildren's weddings," he said through an interpreter.


text:
Care Instructions
- Shower. It's not a great idea to shower with your jewelry on, but once in a while isn't going to do any lasting damage. Just make sure to dry it after.
- Swimming Pool. Take your silver off. Chlorine is a pretty harsh chemical, so if you accidentally forget to remove your silver jewelry before hopping in, make sure to rinse and clean it afterward.
- Hot Tub. Same idea as the swimming pool, but there's even more chlorine in the hot tub and the heat can accelerate the chemical reaction.
- Hot Springs. The sulfur in natural hot springs will wreak havoc on your silver. Unless you're going for that "dark oxidised" look, avoid at all costs.
- Bonus Tip: Chemicals in lotions and perfumes can also cause your jewelry to tarnish. Apply them first, let them dry, and then put your jewelry on. This alone can make a HUGE difference in your silver's luster.


text:
Your borders and prospects may be global and your concepts mind-boggling and earth-shaking, yet your imperfect ability to express yourself accurately in the English language is hindering your efforts. Dont let your lack of English language skills deter you from achieving your potential. ESL proofreading and ESL editing services can help you polish your writing so that you can confidently communicate what you want to express in the most effective manner.
English grammar rules are quite confusing, even for many who speak English as a first and only language. Non-native English speakers often worry that they may not be getting their message across the way they intend to. For students, business people, and others who are learning English as a second language, valuable time and energy can be saved by having an ESL proofreader/editor go over the documents and speeches you write. Use your time and creative energy to think about the concepts you would like to convey and let your ESL proofreader/editor deal with the English grammar rules and spellings you are unfamiliar with.
As you continually use ESL proofreading and ESL editing services and as you read through the edited versions that your ESL proofreader/editor returns to you, you will not only gain confidence in your communication abilities, but your skill in the intricacies of the English language will improve greatly. Just as the best way to be able to tell the genuine from the fake is to be exposed to the genuine, theres no better way to learn how to communicate clearly than to be constantly exposed to the right way of writing and saying things.
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text:
Personal Injury: $1.7 Million Dollar Verdict
AUTO ACCIDENT - Plaintiff, a 43 year old advertising art director claims he was struck by defendant's delivery truck while he was crossing a crosswalk in Manhattan. He suffered a fractured hip and pelvis. A Manhattan jury awarded him $1.7 million dollars. Read On


text:
Hire string quartet in London
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text:
BALA CYNWYD, PA / ACCESSWIRE / October 12, 2019 / Brodsky & Smith, LLC reminds investors of approaching deadlines for lead plaintiff application regarding class action lawsuits against the following companies for violations of federal securities laws. If you purchased any of the below-listed stocks during the referenced time periods and want to discuss your legal rights, please contact Marc Ackerman, Esquire or Jordan Schatz, Esquire at 877-534-2590. There is no cost or financial obligation to you.
VALARIS plc (VAL)
Shares purchased between April 11, 2019 and July 31, 2019
Deadline: October 21, 2019
According to the filed complaint, on July 31, 2019, Valaris issued a press release announcing its second quarter 2019 financial results-which missed market expectations. Upon issuance of the press release, analysts at Seeking Alpha published an article on August 2, 2019, entitled "Valaris PLC - Off To A Bad Start." and noted that Valaris' results "shock[ed] investors with massive cash usage [and] . . . surprisingly weak outlook for the ultra-deepwater segment with further dayrate recovery likely delayed until at least the second half of next year." The article further criticized Valaris' free cash flow for the quarter, which was "negative by a whopping $375 million causing the company's remaining pro forma cash balance adjusted for roughly $741 million in payments related to the recent debt tender offer to decline to just $353 million." Following this news, Valaris' stock price fell $3.25 per share, or approximately 39%, over the two trading sessions following its announcement of its quarterly financial results, to close at $5.02 per share on August 2, 2019.
Additional information can be found at http://www.brodskysmith.com/cases/valaris-plc-nyse-val/ or call 877-534-2590. No cost or obligation to you.
Shares purchased between February 15, 2019 and August 8, 2019
Deadline: October 18, 2019
According to the complaint, throughout the Class Period, the defendants failed to disclose to investors that: (1) Nektar did not comply with current good manufacturing practices; (2) as a result, batches of NKTR-214 were not produced consistently and differed meaningfully; (3) clinical results from PIVOT-02 differed based on the batch of NKTR-214 used in the study; (4) as a result, the PIVOT-02 study did not produce statistically significant results to support a finding of clinical benefit; and (6) as a result of the foregoing, the defendants' positive statements about Nektar's business, operations, and prospects were materially misleading and/or lacked a reasonable basis.
Additional information can be found at http://www.brodskysmith.com/cases/nektar-therapeutics-nasdaq-nktr/, or call: 877-534-2590. No cost or obligation.
Shares purchased between May 22, 2019 and August 1, 2019
Deadline: October 15, 2019
According to the complaint, throughout the Class Period, the defendants failed to disclose to investors that: (1) NetApp was unable to close large deals within the quarter and that the deals were pushed out to subsequent quarters or downsized; (2) as a result, NetApp's revenue would be materially impacted; (3) as a result, NetApp would lower its fiscal 2020 guidance; and (4) as a result of the foregoing, the defendants' positive statements about NetApp's business, operations, and prospects were materially misleading and/or lacked a reasonable basis.
Additional information can be found at http://www.brodskysmith.com/cases/netapp-inc-nasdaq-ntap/, or call: 877-534-2590. No cost or obligation.
Brodsky & Smith, LLC is a litigation law firm with extensive expertise representing shareholders throughout the nation in securities and class action lawsuits. The attorneys at Brodsky & Smith have been appointed by numerous courts throughout the country to serve as lead counsel in class actions and have successfully recovered millions of dollars for our clients and shareholders. Attorney advertising. Prior results do not guarantee a similar outcome.
SOURCE: Brodsky & Smith, LLC
View source version on accesswire.com:


text:
Getting back to practice
Published: 01 May 2007 - 02:34 by SamBWFC
Updated: 24 Sep 2008 - 17:13
Subscribers: Log in to subscribe to this post.
I've been injured for a good four weeks now, damaged ligaments in my left foot in a practice match with a guy from my club. It's killing me to get back doing some exercise and some squash. I've missed the chance to play the remainder of the season's games and now our season is over I'm totally gutted.
I can walk OK, I've yet to try light jogging or anything like that, but do you think it would be fine for me to just go in court and hit some straight drives? I don't want to miss out on practice! Also, I heard swimming is a good exercise as it doesn't put pressure on my foot. Anymore recommendations for keeping up my fitness, as well as practicing for squash?How to add images to Members' Forum posts and replies here...
Please Note: The most recent replies are now at the top!
From SamBWFC - 22 Jul 2007 - 02:13
Hi sorry I've not been on here for a while, been bogged down with exams and things.
I've been going to the gym and swimming to keep up my general fitness, as well as going on court solo practicing all the shots.
I still feel a bit of pain in my foot so I've still not played properly for around three months now. The doctor said it would be back to normal in about two months but I still don't feel right, so I'm going to try to get to a physio next week, I want to be ready for the new squash season.
From rippa rit - 01 Jun 2007 - 14:47
There is
- shoulder work with controlled weight.
- leg presses to keep the strength in your lower limbs
- arm and wrist exercises - curls.
- hand weights for your arms
- dumb bells
Plenty more I am sure too that you can do at home using tubing tied to a post, push ups, situps, crunches, etc.
Boring I know to do it by yourself.
You better yet?
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text:
The mission of Newton Cares is to raise awareness and identify strategies to assist in creating a
Email: email@example.com
Phone: 617-796-1420
|Newton Creates a Community of Caring
On June 4, 2019, community members came together to create a mosaic to help build awareness around suicide prevention and mental health.
|Online Anonymous & Confidential Mental Health Screening
|To take an anonymous and confidential online mental health screening, please click here. After answering a few questions, the user will receive feedback, educational materials, and treatment resources if necessary.
|QPR Suicide Prevention Training
Learn how to respond to someone in distress
Question, Persuade, Refer (QPR)
QPR is a simple educational program that teaches lay people how to recognize a mental health emergency and how to get a person in crisis the help they need.
Participants will learn how to:
If you have a Newton group interested in training please email email@example.com and include the following information:
In addition, please include if your group has a regular meeting space available for the training and if you have access to a projector, screen, sound system, laptop, and chairs.
|Get Help
Call 911 for emergencies
Behavioral Health Treatment Services Locator
Online resources from Riverside Trauma Center
Resources on coping with stress after disaster
Tips on finding a mental health professional
|Partner Organizations
|American Foundation for Suicide Prevention
Cataldo Ambulance Company
DreamFar High School Marathon
Families for Depression Awareness
Family ACCESS of Newton
Home Base
INTERFACE Referral Service
John M. Barry Boys and Girls Club
Middlesex County District Attorney's Office
Minding Your Mind
Multi-Service Eating Disorder Association
Newton Crime Commission
Newton Free Library
Newton Parks, Recreation, and Culture Department
Newton Police Department
Newton Public Schools
Newton Senior Services
Newton-Wellesley Hospital
Newton Youth Commission
Partnerships for Youth
Riverside Community Care
Sameem Associates
The Newton Partnership
Understanding Our Differences
West Suburban YMCA
William James College


text:
Sony VCT-BPM1 Backpack Mount for Action Cam
Free Curbside PickupAvailable at select McBain locations.
» Learn More
Low QuantitiesPlease contact us to verify availability.
Attach Action Cam directly to your backpack strap. Low profile so Action Cam remains inconspicuous. Get the angle you need with tilt and pan capability.
- Secure mounting � Secure your Sony� Action Cam to the strap of your backpack to capture all the action without worry. It's low profile keeps the Action Cam out of your way so you can focus on the task at hand - be it cycling, hiking etc.
- Versatile angle adjustment � Adjust the Action Cam to capture just the angle you want with pan and tilt capabilities of the backpack mount.
- Dimensions � 2 1/8 x 17/32 x2 3/8 inches (52.8 X 13 X 58.4 mm) W x H x D
- Weight � 1.1oz (30g)


text:
Scott leaned against the door. The printer room was always one of Thom's most disliked places at the office but seeing Scott effectively blocking the one exit while reading the print off shot his dislike to unfiltered hatred. I should have known the day would end here, he thought, adjusting his collar for the tenth time since Scott trapped him.
"This is some good stuff," Scott said snickering, "mind if I show a few friends?"
"Actually, no. I-"
"No?" Scott cut him off, "You don't mind? What a good sport."
Thom paled. It wasn't supposed to be seen. It was all a mistake. Why did I have to check my email? There were rules against it for a reason. Whoever thought of that one in particular had to have known the shame of a private matter becoming public.
Scott advanced on him, causing Thom to swallow back his building fear. He wouldn't be intimidated. Much. "Therapy isn't anything to be ashamed of." He tried to sound as believable as his therapist when she said to him but failed. His version sounded like he was convincing himself too.
"Then you have nothing be ashamed of so long as you do what I say." Scott smiled and Thom could see the high school boy who got his way by bullying, blackmailing, and forceful coercion. Sadly, Thom was the high school boy who was knew what it was like to be an ant surrounded by big combat boots.
"I can't. It's against policy." He exclaimed.
"Not if it's one friend looking out for another." Scott gave him a pat on the shoulder that felt more like a threat than friendly reassurance. "You're going to be my personal grunt otherwise everyone will know you go to therapy and why. You won't work anywhere after that."
Scott saw the light die in Thom's eyes. It was over. "But don't worry. This stays between us." He gave another thud of a pat to Thom's shoulder as he tucked the evidence into his pocket.
"How do I know you won't do it anyway?" Thom asked, finally finding his voice.
Scott opened the door and stood there for a while before looking over at his new grunt. "Because friends look out for each other."
Sent to the Wrong Printer
You're at work and you print something personal (and sensitive). Unfortunately, you've sent
it to the wrong printer and, by the time you realize it, somebody else has already scooped it up.


text:
Lists Mystery
5 Things That Made Cats Regarded as Royalty in Ancient Egypt
Just like any other ancient civilization, Egypt also had its favorite animals. It was cats who were domesticated in ancient Egypt. The Egyptians (read more)
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text: Shouldn't buying gifts for your family be FUN! Stores always look beautiful and well decorated with their Christmas displays and are usually always new collections to browse and bargains always be bought, nevertheless the vast majority of Christmas shoppers still feel down regardless within the effort from shopkeepers to create everything look Christmassy and encouraging. The traditional first anniversary gift is paper as well as the modern is clocks. Paper is actually quite easy, because it will be something like [[Niall Horan Concert Chicago>http://Niallhorantickets.org/]] Tickets, or something like that really sentimental like seats for money trip to all your honeymoon vacation destination. Of course, the paper could even be the gift wrap on the present. Another romantic idea would be for a husband in order to his wife a [[bracelet>http://www.Msnbc.com/search/bracelet]] or ring to match the associated with her wedding jewelry. An additional tip should be to set the air station's phone number directly on the own telephone memory. This will allow instant access to the hot line of your radio station, especially to manage open up their telephone lines to callers. Recognize that speed is really a great aspect to get tickets. Make a record and stay tuned in in to many other stations quite. Even though it enjoyable to observe your selected radio station, you may missing the other promotions in the event you do not scan another stations in your town. Always remember that artists usually gift promotional tickets to various stations. Merely cannot manage to look over all those free tickets floating about. You cost an old friend of yours, someone you haven't seen remember. He invites you out for lunch and cold drinks. At the end of the night, he insists on memorizing the tab: $200. You wish to split the check, but he insists on salary. Brown would be a natural dancer since this of more. But as a Vocalist, Brown doesn't realize his talent until much later as he turn 17. Before then Brown aspired to turned into a rapper. If in order to truly unique, it no matter how a number of other people have been in the same market. Brad Paisley doesn't try to get like George Strait. Sugarland doesn't act as like Carrie Underwood. Rest is really thinking concerning your unique benefits and certain they are expressed just about every element of one's business communication - in-person, print materials, websites, phone conversations, etc. In marketing we call vid USP (Unique Selling Proposition). If a wonderful a USP, or know what it is, or incorporate in buying aspects of the business, you're just maintaining, at top. But the goal of an organization should be to grow. You're either growing or desperate. If you can't handle, or don't wish to handle, growth, sell enterprise to someone who does. Don't obtain from scalpers and you will be going to almost eliminate the potential for you investing in a fake ticket. A good way to spot a scalper is that they're going to pretend one of the customer, usually, trying to get rid of their ticket because of varied reason. It's not at all a good idea to pay for anyone that approaches you in therefore because it's quite possible that effectively just trying to take cash and, regardless of whether they act extremely sincere, it inclines that functional indeed. Fake tickets are common, however when people stop buying them from scalpers, they become less simple. For more tips about concert tickets, browse here.


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For adults suffering from dental fear, a routine cleaning and visit to the dentist can cause significant stress and anxiety. To help ease these anxieties, Dr. Bill Vagenas offers sedation dentistry in Brockton MA. Our sedation dental services transform stressful appointments into comfortable, positive experiences.
Sedation dentistry uses varying strengths of medication during dental procedures as a way to help patients relax. Sedation dentistry has provided a comfortable way for individuals struggling with dental anxiety to receive dental care.
At our Dental Office in Brockton MA, we offer oral conscious sedation as a way for adult patients to undergo both routine and complex dental procedures in a conscious yet fully relaxed state.
There are a number of benefits associated with sedation dentistry. Sedation dentistry is versatile. As the medication is safe for most adult patients, even those individuals without dental anxiety can also incorporate sedation dentistry in their treatments. Often, patients requiring several treatments during a short period of time request sedation as a way to make the appointment more relaxing.
With sedation dentistry, not only do patients not remember the majority of their procedure, they also do not feel their procedure. While a local anesthetic may be used for some procedures, patients can often enjoy their dental care with increased comfort.
This level of comfort can change an individual's perception of dental visits. After receiving care in a positive environment, nervous patients may become less resistant to the idea of routine visits. As a result, they may become more likely to visit the dentist regularly, improving their long-term oral health through completing routine check-ups.
Prior to the procedure, Dr. Vagenas prescribes the medication to be taken about an hour before visiting our office. While it is often mislabeled as sleep dentistry, patients remain fully conscious and responsive during treatment; however they often do not recall the procedure itself.
Given that medication can stay in your system for several hours, patients do need to make arrangements for a family member or friend to drive them to and from the appointment.
Dr. Bill Vagenas and his compassionate dental team are dedicated to helping all patients achieve beautiful smiles.
To learn more about sedation dentistry, contact our Brockton dentist office or schedule an appointment today.
Bill Vagenas DMD, LLC | 5 Torrey Street, Brockton, MA 02301
Phone: (508) 586-4276
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MINNEAPOLIS (AP) — Joe Mauer drove in two runs, including the go-ahead double in the eighth inning, to push the Minnesota Twins past the Chicago White Sox 4-2 Thursday night.
After rain delayed the first pitch by 2 hours and 6 minutes, the Twins stopped their season-high, five-game losing streak. Mauer, in the middle of the worst year of his six-time All-Star career, also hit a tying single in the third. After 18 games without an RBI, Mauer has three in three days.
With Jake Petricka (0-2) pitching with runners at the corners with no outs, Mauer hooked a drive down the left-field line. Kurt Suzuki tacked on a sacrifice fly.
Glen Perkins tossed a scoreless ninth for his 18th save in 20 tries, after a bad back kept him from pitching Wednesday in Boston.
Casey Fien (4-4), who subbed as the closer Wednesday and gave up two homers in the 10th inning in a 2-1 loss to the Red Sox, returned to the eighth-inning role and earned the victory that really belonged to Yohan Pino.
Pino at age 30 became the oldest Twins player to make his major league debut, holding the White Sox to two runs in seven innings.Comments
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text:
The purpose of this support document is:
To summarize and build on the recommendations described in the Assembly of First Nations (AFN) Special Education Policy document in order to provide a framework for assisting First Nations in supporting, promoting and enhancing the rights of all children, particularly those with exceptionalities, within their communities. And to foster capacity building around developing special education policy for First Nations.
Updated Oct. 2016
Download the FNSEPH (PDF files):
Cover & Table of Contents
Section A: Philosophy and Goals
Section B: Framework to Student Service
Section C: School Special Education Planning and Policy
Section D: Resource Program
Section E: Planning for Student Success
Section F: Special Education Funding Guidelines
Section G: Special Education Personnel
Section H: School Support Personnel
Section I: Early Years
Section J: Code of Ethics
Section K: Extended Services
Section L: Extended Programs
Section M: Community Support
Section N: Transportation
Section P: Definitions
Section Q: Glossary of Associations/Organizations
Section S: MFNERC Support Personnel Phone Directory
Section T: Provincial Legislation/Documents for Provincial Schools
Section U: Universal Design
Section V: Other Information and Sources


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Hi Innovators!
We've uploaded a modification to the rules (see the resources tab or link), which revises Section 3.5 How We Determine Winners to classify advisory judges as reviewers, and specified conflict of interest requirements for the final judge. The modification does not impact any submission requirements or judging criteria, however we encourage you to review the changes to familiarize yourself.
Also a quick reminder on the Sept. 11 submission deadline. The deadline on the 11th is set at 5 P.M. ET please make sure that you've checked your local time to make sure that you do not miss the deadline. No submissions will be accepted after 5 P.M. ET.


text: I'd like to take a moment to welcome you to our community at Jerri's Kidz located in the Williams Bay Elementary School. We are excited to get to know you and your children! Jerri's Kidz, LLC is a privately-owned group childcare center licensed by the State of Wisconsin. We provide care for children ages 4—12. The Williams Bay School District rents space to Jerri's Kidz, LLC at the school to provide wrap-around school-age childcare services for the children in our school district. We offer three types of services: Before School Care: 7:00 am - 8:30 am $5.00/session Children play games, finish up homework, work on crafts and chit-chat, of course. Children are welcome to bring in breakfast if they choose. After School Care: 3:30 pm - 6:00 pm $8.00/session All children meet in the cafeteria for attendance and center provided snack. Weather permitting, we play outside, then we may come in for games, crafts, and fun socializing. When we play inside due to inclement weather, we utilize both our classrooms. Children in 4K – 1st grade play in our primary room – room 151. Those in 2nd – 6th grade stay in the cafeteria. Preschool Care: 11:15 am—3:30 pm $16.00/session Children are escorted from the 4K classroom to Jerri's Kidz (room 151). We use a play-based curriculum. The classroom is arranged to facilitate support of letters, shapes, colors and concepts as introduced in 4K. We play games, puzzles, crafts, books, outside play, etc. Our primary focus is having fun and learning how to be good friends! Interested in enrolling? The following links will provide you with additional information: Parent Policies 2018 Additional Information for Preschool Children Your Guide to Regulated Child Care USDA Food Requirements 2018 To Enroll: Use the links below, to print out and complete the following forms: Parent-Provider Contract Schedule Request Form 2018-2019 Photography Consent Form Child Care Enrollment Form Health History and Emergency Care Plan (2 pages) Stop at the Jerri's Kidz table at school registration on Wednesday, August 22nd between 4 - 7 pm. Drop off paperwork Pay Registration Fee - $15.00 per family We'd love to meet you!


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This recipe started out with me wanting to make a gluten- and dairy-free pumpkin dessert that could be eaten by hand at a party. But I didn't just want to make regular one-layer pumpkin bars or pumpkin blondies, and I wanted it to have a little more to it than pumpkin pie – but it definitely had to have a crust. I found recipes for pumpkin layer bars, but they all had coconut or coconut butter, which I feel takes away from the pumpkin-ness a bit.
After much research, inspiration, and experimentation, I present to you: Four-Layer Paleo Pumpkin Bars. Almond meal crust, date-cashew butter caramel, creamy pumpkin custard, and crisp maple pecans. They're a bit of work, a little rich, and ultimately indulgent… but best of all they're clean as can be. No refined sugar or anything :)
Be sure to keep the bars refrigerated until serving, otherwise the pumpkin and caramel layers will soften and become much harder to eat with your hands. If you don't mind the mess or prefer to eat them with a fork (perhaps topped with some dairy-free ice cream?) then disregard this and do yo' thang.
This recipe is:
• Gluten-free
• Dairy-free
• Soy-free
• Refined sugar free
• Paleo


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Its that time of year when I take my summer coop from this
|Jodies Summer Coop
To this
Beautiful colors bursting with burnt oranges, deep reds, vibrant purples and gold everywhere we turn.
Maybe fall is your favorite because you can have your first fire, pumpkin muffins with coffee or maybe, you just like wrapping up in a soft comfy blanket with hot tea and a good book.
All those reasons sound pretty good to me, but I have a few others as well.
I always loved decorating the inside of my home this time of year, but recently got into decorating my chicken coop....I know I spend way to much time on pinterest seeing so many cute ideas, that's where it all started I guess.
Decorating my coop for fall was pretty easy and very cheap because I already had almost everything I needed.
As you can see I filled it up pretty well with what I had on hand
I had to switch things around a few times and even remove some things until I had it just the way I wanted.
Like with my It's Fall Y'all sign which really needed to be redone anyway.
I had originally taken an old piece of wood and painted part of it with chalkboard paint so I could change up the saying. After a good rain I realized it wasn't practical having it outside (the chalk came off). So last year I painted it with a permanent saying. I am still not happy with the sign and will redo it again at some point. The lettering wasn't very clear, and I would like to change that along with my other sign.
I ended up removing the sign because once I stepped back & looked at the coop as a whole, I just did not like it.
B Ray, The Scarecrow pictured above is simply propped up with the top of his head attached to the coop by a small hook.
The flower box holds artificials I bought probably 9 years back at the dollar tree when gathering decorations for my wedding..That's a whole other story, I bought so many things and ended up using fresh flowers from the florist and using artificial sparingly.
Speaking of the Scarecrows It's a whole family of them
My scarecrows are also a grab years ago from the dollar store possibly dollar general this time, and if so I would have gotten them at the end of the season when they were marked down.
When I first purchased them I decided they should each have a name representing my family.
I used glow in the dark fabric paint and added the names to the hats.Very cute the first year when the names glowed in the dark. By the second year they didn't glow any longer. Some of the fabric paint has came off as well, but that's fine,it gives us all character I think.
I nestled these scarecrows into a planter box which contained raffia and some artificial pumpkins. The planter has dirt in it, so inserting the sticks into that worked well. The pumpkins and raffia ...BINGO you got it...Dollar store AGAIN!
The Garland
I leave the green garland up year round and was purchased after Christmas one year. I incorporated the leaf garland around the outside of the coop just by twisting the two together. It can be easily removed when fall is over. It took several pieces to do the coop and I did have to sacrifice these from the inside of the house.They are one of my favorite things to decorate with because they hold up so well from year to year and can be fairly inexpensive depending on where you purchase them.
The fresh pumpkins!
If you have chickens then you know how they love fresh pumpkin's.
As a matter of fact the day my In Laws brought over a load from their garden, I had them just sitting on the front porch. Later that day my little guy kept saying I hear a funny noise. After a while he peeked out the blinds and he started shouting THE CHICKENS ARE EATING THE PUMPKINS!
I quickly ran outside, scared them away and brought them inside.
I honestly had no idea at first how I would ever be able to use the fresh pumpkins around the coop. I was thinking right off they had to be off the ground.
With that being said, since chickens can fly, I knew it was a risk.
I went on a search in my garden shed and ran across the old hanging planter.
It was given to me by a lady who gets wood from us. She said it had been her Mothers and had been stored under the house for years. She was cleaning out and asked if I wanted it. OF COURSE I DID.I love hand me downs. I used this planter a couple years outside with live plants but hadn't used it at all this year. I decided to hang it under the roof of the coop and now I am keeping my fingers crossed that the chickens will not discover my fresh pumpkins.
You may not have a coop to decorate but I hope you will be inspired to decorate something
A Porch
Mail Box
or even a
Dog House.
This was such a fun project for my little one and I
It was a beautiful fall like day that we spent some great mommy son time together.
I enjoy decorating my coop for my favorite time of the year, and I will enjoy this until December when it's time to decorate for Christmas.


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1Department of Pharmaceutical Chemistry, Acharya and BM Reddy College of Pharmacy, Chikkabanavara, Bengaluru 560107, Karnataka, India, 2Department of Chemistry, Christ College, Irinjalakuda 680125, Kerala, India, 3Department of Pharmaceutical Chemistry, Nirmala College of Health Science, Chalakudy 680311, Kerala, India
Email: firstname.lastname@example.com
Received: 02 May 2017 Revised and Accepted: 30 Jun 2017
Objective: The existence of keto-enol tautomerism in β-diketones can typically study by a choice of analytical technique. The position of the keto-enol equilibrium depends on a number of factors like solvent, temperature, and substituents. Here an attempt was made to examine the effect of indole, a heterocyclic moiety with the moderately high polar surface area to examine its effect on ketonisation of β-diketone.
Methods: The β-diketone studied and synthesized is a structural analog of magical drug curcumin. The structural influence of indole on ketonisation of β-diketone is studied to give a hypothesis on factors contributing towards ketonisation. This work involves the synthesis of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione and the study on the single crystal structure of indole-3-carboxaldehyde, major functional component to result in the reaction. The tautomer was studied for its ability to bind with tetrahydrofolate reductase enzyme using Discovery Studio 3.5 version to differentiate the pharmacological significance of conformations.
Results: The single crystal XRD structure of this compound was deposited in Cambridge crystallographic data center bearing CCDC No.1536311. The structural characterization of synthesized ligand was carried out by using IR, Mass, 1H NMR spectroscopic techniques. The docking study reveals that keto isomer found to exhibit more inhibition of the enzyme tetrahydrofolate reductase hence more pharmacologically active.
Conclusion: The experimental evidence proves that indole substitution shifted the keto-enol equilibrium towards keto form of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione.
Keywords: Keto-enol tautomerism, β-diketones, 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione, Structural analog, Curcumin, Single crystal XRD, IR, Mass, 1H NMR, Docking
© 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
DOI: http://dx.doi.org/10.22159/ijpps.2017v9i8.19576
Curcuminoids, the active chemical components present in Indian medicinal plant turmeric (Curcuma Longa, Linn, Zingiberaceae family) have various biological activities, including antioxidant, anti-inflammatory, anti-arthritic and anti-tumor activities [1, 2]. The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination [3]. Curcumin adjuvant therapy, solid dispersion, liposomal curcumin and synthetic analogs of curcumin are a few methods used to overcome these drawbacks [4]. Out of this, the synthetic analogs and their pharmacological screening are studied vastly in the past few decades [5]. The structure (fig. 1) can be related to a series of similar molecules which resulted as an attempt to synthesize synthetic curcumin of 6-aryl-5-hexene-2, 4-diones series [6, 7]. Structurally, this is α, β-unsaturated 1, 3-diketone with an indole substitution on its left terminal. A series of aromatic and heteroaromatic compounds were already counted under this class proved to exist in enol form [8]. The same synthetic route, when tried with 1H-indole-3-carboxaldehyde gave a conflict.
Fig. 1: Structure of 6-(1H-Indol-3-yl)-hex-5-ene-2, 4-dione
Normal β-ketones have a tendency to exist in enol, as it is more stable. This can be explained by considering the ability of enol form to contribute stable six-membered cyclic structures through hydrogen bonding as shown in structure (fig. 2). Studies suggest that the amount of Enol form decreases when a bulky alkyl substituent present at the α-position [9]. Bulky alkyl groups such as the isopropyl group or the Sec-butyl group decrease the quantity of enol form to almost 0%. The presence of an alkyl substituent on the α-carbon decreases the amount of enol form. The bearing of a chlorine group at the α-position increases the amount of enol form to 92%. According to Burdett and Rogers [10], the presence of electron-withdrawing groups, such as CF3 favors the enol form. When four or more fluorine atoms are present in the molecule, the enolization is complete. Also, phenyl groups favor the enol form. The lower the polarity of the solvent, the higher is the percent of the enol form. In CCl4, 94% of the acetylacetone molecules are present in the enol form, whereas in acetonitrile this value is scaled down to 36%. The amount of enol form decreases with increasing temperatures. The NMR study of solution structures of curcumin in solvents ranging in polarity from CDCl3 to mixtures of DMSO-d6 in water, and in buffered aqueous DMSO-d6 solutions with pH values varying from 3 to 9, found that curcumin exists in solution as keto-enol tautomer, The titrimetric chloramine-T oxidative methods were used earlier for the determination of percentage of enol form of in the β-dicarbonyl compounds [11, 12]. The ability of these β-keto compounds to involve in the synthesis of medicinally active heterocyclic compounds were studied extensively in past few years [13, 14]. But when it comes to β-dicarbonyl compounds in the solid state, use of spectroscopic methods like 1H NMR, single crystal XRD methods has to be used sensibly to distinguish the confirmation.
Fig. 2: Keto-enol tautomerism in β-ketones
It was interesting to note that indole; a bicyclic heterocyclic ring system has not reported contributing an impact on keto existence of diketone in any of this literature. This can be explored only by considering indole as a substituent on β-diketone, which is broadly studied for its substitution with aliphatic and aromatic groups. The available literature of substitution with benzaldehyde with the less polar surface area to vaniline with more polar surface area show the shift of equilibrium towards enolization. One such example 6-aryl-5-hexene-2, 4-diones (fig. 3) being a synthetic analog of curcumin was studied vast in previous years [15, 16].
Fig. 3: Structure of 6-aryl-5-hexene-2, 4-diones
Curcumin research on synthetic analogs now turned into a stage, where researchers have to focus on identification of pharmacophore which needs to be altered for improving the efficacy as a drug candidate. There has an ongoing debate regarding α, β-unsaturated diketone system exists on curcumin as the reason for magical effect of the drug [17]. The keto-enol isomeric effect on structural pharmacophore may play an important role in binding of this analog with drug target. The relationship between tautomeric structures of curcumin and its effect on neurodegenerative diseases like Alzheimer's was the research of interest for the present [18]. So the initial efforts were taken to study the effect of indole by synthesis of 6-aryl-5-hexene-2, 4-diones using 1H-indole-3-carboxaldehyde. This special case captured attention while trying to synthesise a novel series of heteroaryl hexanoids using different heterocyclic aldehydes. So here focus was given on indole as a special case which demonstrated a change in structural geometry of synthetic analogs of this series. Efforts were made to study this reason by altering reaction conditions and reagent concentrations. The single crystal XRD structure of 1H-indole-3-carboxaldehyde is studied for its influence on bond angle and bond length on ketonisation. The ongoing research in this field suggests that proteinaceous drug receptors frequently preferentially bind a tautomer that is present in low abundance in water [19]. So the proper treatment of molecules that can tautomerize them either keto or enol form is a challenge for medicinal chemist.
Dihydrofolate reductase, one of the targets for antifolate-based drugs has been validated by researchers for the screening of pharmacological activities in related compounds [20]. The drug, which is a potent inhibitor of dihydrofolate reductase (DHFR) acts by preventing the synthesis of tetrahydro folic acid and inhibiting cell growth and multiplication. The surviving evidence from docking studies on this heated discussion of pharmacological activities of keto-enol forms favours keto form in case of curcumin [21]. The same approach on 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione, a synthetic analog of curcumin by using dihydrofolate reductase enzyme will shed light on synthetic chemist who works on modification of these analogs.
All the chemicals utilized in this study were AR grade purchased from Sigma-Aldrich. Melting points were determined by open tube capillary method and are uncorrected. Instruments used in this investigation are UV-1601 Shimadzu recording spectrophotometer, Thermo Nicolet, Avatar 370 FTIR spectrophotometer, Jeol/Sx-102(FAB) mass spectrometer, Varian, Mercury Plus 300 MHZ NMR spectrophotometer, Bruker Kappa Apex II diffractometer. The keto and enol conformations are docked using Accelrys Drug Discovery Studio 3.5. The structure of the enzyme tetrahydrofolate reductase complexes was obtained from a Protein data bank (PDB code: 7DFR) and was used for docking. The chain-A is retained and the crystal structure was cleaned by deleting the ligands and other heteroatoms. The prepared ligands were docked by using CDocker. Docking calculations were carried out using Accelrys Drug Discovery Studio (3.5version)
Synthesis of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione [22-24]
Acetylacetone (0.075 mol) mixed with boric oxide was suspended in dry ethyl acetate (50 ml) containing tri(sec-butyl) borate (0.1 mol). To this combination kept at about 0 °C, a solution of 1H-indole-3-carboxaldehyde (0. 025 mol) in dry ethyl acetate (15 ml) and n-butyl amine (0.5 ml) was added dropwise for 90 min with continuous stirring. The stirring was continued for an extra period of about 2 h and the solution was set aside all night. The reaction mixture was then stirred for about 1 h with hot (50 °C) hydrochloric acid (0.4 M, 20 ml) and extracted over and over again with ethyl acetate. The collective extracts were concentrated under vacuum and purified by column chromatography (silica gel, mesh 60-120). The yellow band developed in the lower section was recovered by successive elution with 5:1 v/v mixture of chloroform-acetone and the combined eluates on evaporation yielded 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione. Scheme of synthesis outlined below. (fig. 4) The isolated 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione was recrystallized from hot benzene to get chromatographically (TLC) pure material. The unreacted 1H-indole-3-carboxaldehyde was separately eluted from the reaction mixture using the same solvent system and used for crystal study.
Fig. 4: Scheme of synthesis of 6-(1H-Indol-3-yl)-hex-5-ene-2, 4-dione
Single crystal study
The unreacted 1H-indole-3-carboxaldehyde was separated by column chromatographic method using 5:1 v/v mixture of chloroform-acetone from the reaction mixture and used for crystal preparation. Deep yellow plate-like crystal of 1H-indole-3-carboxaldehyde was prepared by crystallization of the compound from a mixture of ethanol-toluene-ethyl acetate mixture. The compound was dissolved in the solvent mixture at room temperature in a 50 ml conical flask and the mouth was closed with cotton to allow slow evaporation of the solvent and kept aside for about 2 w when a plate-like crystal was separated. A crystal with 0.40 x 0.30 x 0.20 mm was used for obtaining X-ray diffraction data. XRD data were collected on a Bruker Kappa Apex II diffractometer. To solve the structure all crystallographic calculations were performed using Shelxl program package.
Characterization of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione
The derivatives were recrystallized from hot benzene to get chromate-graphically (TLC) pure material to yield product (60%) in the yellow to orange crystalline form. The UV absorption band 280 nm, IR (ν) 1668 (C=O acetyl stretch), 1635.5 (C=O cinnamoyl stretch), 1518.8 (asymmetrical C-C-C chelate ring stretch), 1443.3 (symmetrical C-C-C chelate ring stretch), 997.2 (CH=CH stretch); 1H NMR δ 3.3 (s, 3H,-CH3), 4.9 (s, 2H,-CH2), 7.3 (td, 4H, Ar H-4, H-5, H-6, H-7, J=3.50 Hz), 7.5(d,1H, CH,-α, β-unsaturated, J=8.0 Hz), 8.1 (s,1H, Ar H-2), 8.2(d, 1H, C=CH, J=7.0 Hz,), 9.9 (s, 1H,-NH); EIMS m/z 227 [C14H13NO2]+, 170.06 [C11H8N0]+, 129.06 [C9H7N]+,117.0 [C8H7N]+; Accurate mass found [C14H13NO2]+: m/z 227.0, calculated for [C14H13NO2]+; 227.09.
Crystallographic study
The ORTEP view and PLATON diagram (Shelxl program) of the molecule with the labeling of non-hydrogen atoms are shown in fig. 5 and fig. 6.
Fig. 5: 1H-indol-3-carboxaldehyde
Docking studies on isomer
The extent of biological activity variance on confirmations is studied by docking the keto-enol conformations against the selected enzyme dihydrofolate reductase. The amount of inhibition made by the conformations is studied by evaluating the result obtained after docking the conformations separately by using CDocker program. The CDocker energy and CDocker interaction energy were calculated. The scoring functions and hydrogen bonds formed with the surrounding amino acids are used to predict their level of inhibition on binding sites of dihydrofolate reductase receptor. The types and number of interactions between the synthesized ligand and enol confirmation were shown in fig. 8-9 (Discovery Studio 3.5, CDocker program). The CDocker energy, CDocker interaction energy for first three leads and number of hydrogen bond length are listed in table 2-3.
Fig. 6: 1H-indol-3-carboxaldehyde (PLATON)
Fig. 7: Arrangement of molecule in crystal of 1H-indol-3-carboxaldehyde
Crystal data and structure refinement: 1H-indole-3-carboxaldehyde
|Identification code
|Empirical formula
|Formula weight
|Crystal system, space group
|Orthorhombic, Pca21
|Unit cell dimensions
|a = 14.0817(11) A alpha = 90 deg.
|b = 5.8006(5) A beta = 90 deg.
|c = 8.6895(6) A gamma = 90 deg.
|Z, Calculated density
|4, 1.358 Mg/m^3
|Absorption coefficient
|0.090 mm^-1
|Crystal size
|0.40 x 0.30 x 0.20 mm
|Theta range for data collection
|2.89 to 28.35 deg.
|Limiting indices
|Reflections collected/unique
|5287/1617 [R(int) = 0.0236]
|Completeness to theta = 28.35
|100.0 %
|Absorption correction
|Semi-empirical from equivalents
|Max. and min. transmission
|0.9822 and 0.9648
|Refinement method
|Full-matrix least-squares on F^2
|Goodness-of-fit on F^2
|Final R indices [I>2sigma(I)]
|R1 = 0.0341, wR2 = 0.1021
|R indices (all data)
|R1 = 0.0422, wR2 = 0.1176
|Absolute structure parameter
|Extinction coefficient
|Largest diff. peak and hole
|0.159 and-0.138 e. A^-3
Table 1: Bond angles and bond lengths
|Atom to atom
|Bond lengths [A °]
|Atom to atom
|Bond angles (deg)
Table 1
Fig. 8: Binding configuration of keto isomer
Fig. 9: Binding configuration of enol isomer
Table 2: Statistical docking results of keto isomer (discovery studio 2.5 software)
|CDocker energy
|CDocker interaction energy
|Nature of Hydrogen bond
|A: ALA7: HN-Molecule: O16
|Molecule: H30-A: MET16: O
|Molecule: H30-A: GLU17: O
Table 3: Statistical docking results of enol isomer (discovery studio 2.5 software)
|CDocker energy
|CDocker interaction energy
|Nature of Hydrogen bond
|A: ALA7: HN-Molecule: O17
|Molecule: H29-A: SER49: OG
The UV absorption band is very broad and shows the presence of more than one peak indicating the presence of more than one isomeric form in the ground state. The high energy band at 280 nm due to π→π* transitions of the fully conjugated system is marginally influenced by indolyl groups. The IR spectra of the diketones show the prominent band at 1635.5 assignable to the cinnamoyl ѵ(C=C) vibrations. The observed position and intensity of these bands indicate that the compound exhibit strong shift to keto form. A medium intensity band at 997.2 cm-1 in the spectra of the compounds can be assigned to the trans-CH=CH-absorption [25, 26]. The proton magnetic resonance spectra indicated that the synthetic analog existed entirely in the keto form rather than the enol form in deutero-methanol solution. The signal due to methylene carbon of keto tautomer was observed as intense peek in δ value 4.9 [27]. The mass fragmentation patterns depend mainly on the nature of groups attached to the dike to function. Elimination of O, OH, CO, C3HO2+, CH2=C=O (ketene), etc are characteristic of acetylacetone and related 1, 3-diketones [28]. On common practice, the β-diketones prefer the cis enol configuration stabilized by a strong intramolecular hydrogen bond. The information gathered from above results was found contrary to the above statement. The XRD results reveal that the crystal crystallizes in orthorhombic system with lattice parameter values, a =14.0817 A °, b =5.8006 A °, c =8.6895 A ° with a slight marginal difference from reported XRD values of 1H-Indole-3–carboxaldehyde [29, 30]. This ruled out the possibility of polymorphism of crystals under high-temperature reaction condition. The data obtained from single crystal XRD study of 1H-indol-3-carboxaldehyde used here to give evidence for keto existence. The unit cell parameters, experiment details, and refinement parameters are listed above. Analysis of bond length and bond angles (table 1) reveals that the molecule is planar with slightly tilted C=O bond with O(1)-C(9)-H(9) bond angle is 117.5 °. It was attention-grabbing to identify that, normal CHO bond is trigonal planar with angle 120 °. The O(1)-C(9) bond length was found to pretty long 1.217 A °. The comparison of XRD results of the title compound with reported aldehydes strongly suggests different geometry for 1H-indol-3-carboxaldehyde. Further analysis of hydrogen bonding network in the crystal pattern of 1H-indol-3-carboxaldehyde reveals the presence of four molecules in unit cell as shown in fig. 7 (Shelxl program).
The docking energy scores suggest that the keto form of the ligand has slightly better binding energy values in comparison with the enol isomer of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione. But upon examining the interactions with the active binding site of the receptor, the keto isomer has a number of prominent and strong electrostatic interactions with amino acid residues like ALA: 7, TYR: 100, ASN: 18, THR: 123, ALA: 19, ASP: 122, THR: 46, GLU: 17, MET: 16. In the case of enol derivative, major interactions are of weak Van der Waals kind. Further, it is interesting to notice that the keto isomer exhibit three hydrogen bonding interactions amino acid residues in the receptor namely ALA7: HN-Molecule: O16, Molecule: H30-MET16: O and the third one with the same hydrogen atom (H: 30) in the molecule with GLU: 17. Whereas the third hydrogen bond from NH of the molecule is absent in enol isomer. Hydrogen bonds play a crucial role in defining the specificity of ligand binding. Most of the studies show that hydrogen bond and other polar interactions are playing important role in finding the proper orientation of the molecule to make maximum interactions [31]. The keto isomer was found to be more compact with three hydrogen bond interaction with amino acid residues exhibiting stronger inhibition of dihydrofolate reductase enzyme. In the enolic confirmation, the conjugated dienyl existence of molecule was thought to contribute some conformational changes in the molecule and hence steric hindrance. This steric hindrance may the reason more hydrophobic interaction and poor inhibition of enolic isomer with dihydrofolate reductase enzyme.
The results from IR band 1635.5 (C=O cinnamoyl stretch) supports the ketonic existence of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione. This is further supported by the fact observed in 1H NMR spectrum with δ value 4.9 clearly corresponds to active methylene on α position of the β-diketone system. There was no peak at δ value 15 and above clearly ruled out the chance for the existence of enolic hydrogen. The hypothesis gave here based on literature survey and experimentation highly in favor with substituent effect of indole. Electronic effects or active polar surface area of the molecule has not found to play a major role on ketonisation. The experimentation with changing reactant concentration and reaction condition has not contributed to enolization with indole-3-carboxaldehyde. Unlike other Carboxaldehyde, change in bond angle from normal trigonal 120 ° along with intermolecular hydrogen bond exists between indole-3-carboxaldehyde has found to play a major role in this context. This has added significance as the tested indole-3-carboxaldehyde used for crystal formation is extracted from reaction mixture used for preparation of 6-(1H-Indol-3-yl)-hex-5ene-2, 4-dione. All the available evidence in this study suggests the shift of equilibrium is more towards keto form. This equilibrium can be affected by other substitutions in the molecule. The effects of other substitution in indole and on β-diketone need to be studied in future. Further docking study performed on dihydrofolate reductase enzyme revealed that the keto isomer will be the best conformation with maximum binding and better predicted pharmacological activity.
Authors are thankful to the management of Christ College, Irinjalakuda, Kerala, Cochin University of Science and Technology, Kerala and Acharya and BM Reddy College of Pharmacy, Bengaluru for providing necessary facilities to carry out this work successfully.
Krishnakumar KL: Design of work, Literature review, synthetic part, drafting the article.
Mathew Paul Ukken: Data analysis, Revision of article.
Manju R: Revision of article and interpretation of results.
Declared none
Shaymaa HA, Manal KA, Akram AN. The potential benefit of curcumin adjuvant therapy to the standard helicobacter pylori eradication therapy in patients with peptic ulcer disease. Asian J Pharm Clin Res 2017;10:313-7.
Muhammad D, Andi S, Edi M, Umar AJ, Masashi K. Apoptosis induction effect of curcumin and its analogues pentagamavunon-0 and pentagamavunon-1 on cancer cell lines. Asian J Pharm Clin Res 2017;10:373-6.
Sarvesh S, Gaurav KS, Vimal K. Development of spectrophotometric methods for simultaneous determination of artesunate and curcumin in a liposomal formulation. Int J Appl Pharm 2015;7:18-21.
Rubendra K, Dinesh Kumar M, Dinesh Kumar J. Solid dispersion: a novel means of solubility enhancement. J Crit Rev 2016;3:1-8.
Karpakavalli M, Preethi K, Sanglimuthu A, Kumar EP. Docking, synthesis, characterization and anticancer activity of 4-(4'-hydroxy, 3'-methoxy) phenyl, but-2-one-3-ene, a curcumin analogue precursor. Int J Curr Pharm Res 2016;8:1-5.
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Mathew PU, Venugopalan P, Krishnankutty K. Metal chelates of 5-aryl-1-phenyl-4-pentene-1,3-diones. Asian J Chem 2002;14:1335-40.
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Umesha KB, Lokantha Rai KM, Ajay Kumar K, Sudha BS, Khanum SA. A new approach for the determination of the percentage of the enol form in the β-keto carbonyl compounds using the chloramine-T oxidative method. Oxidation Commun 2004;27:831-5.
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Umesha KB, Lokanatha Rai KM, Ajay Kumar K. A novel synthesis of isoxazoles via 1,3-dipoar cycloaddition of nitrile oxides to acetylacetone. Synthetic Commun 2002;32:1841-6.
Umesha KB, Lokanatha Rai KM, Ajay Kumar K. A new approach to the synthesis of pyrazoles via 1,3-dipolar cycloaddition of nitrile imines with acetylacetone. Indian J Chem 2002;41B:1450-3.
Krishnankutty K, Muhammed BU, Mathew PU. Some unsaturated β-diketones and their metal chelates. Trade Sci Inc 2009;4:78-82.
Muhammed BU, Anjali K, Mathew PU. Metal complexes of unsaturated poly carbonyl compounds derived from benzoyl acetone and aromatic aldehydes. J Iran Chem Res 2010;3:71-81.
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Krishnakumar KL, Mathew PU. Metal complexes of heterocyclic unsaturated 1, 3-diketones. Int J Pharm Sci Res 2013;4:1154-8.
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How to cite this article
Krishnakumar KL, Mathew Paul Ukken, Manju R. A study on effect of indole as a substituent on a keto-enol tautomer: a synthetic approach on β-diketone. Int J Pharm Pharm Sci 2017;9(8):219-224


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text: Investigation Effects of Different Catalysts and Ethylene Glycol (EG) on Chemical Degradation of Poly (Ethylene Terehpthalate) (PET) text article 2013 per PET wastes from post consumer bottles can be chemically degraded into some compounds such as oligomers and some monomers such as bishydroxy ethyl terephthalate(BHET)by some catalysts(Zn, Co, Pb and Mn acetates) in ethylene glycol at 189 oC under N2 atmospheric pressure. The compounds obtained in the chemical depolymerization can be used as plasticizers in paint, fibbers, rubbers and plastic industries. One of the most important compound obtained in this process is BHET which can be used as a monomer for production of some special polyester grades, epoxy resins, polycarbonate and polyureatanes.Characteristic properties of the products were studied by some instrumental techniques such as IR, TGA and DSC Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 3 11 https://pr.ripi.ir/article_258_2c9500233ad328c42a1afdb870ac5a49.pdf Rapid Design Algorithm for New Technology: Shell and Tube Heat Exchangers with Helical Baffle text article 2013 per "Shell and tube heat exchanger with helical baffles" is one of the new technologies used to improve the performance of common heat exchangers with segmental baffles. Although the advantages and efficiencies of these baffles are known well and they have been used in many developed countries, however, scientific and technical information concerning them have rarely been published. In this article, after introducing some present technologies to improve the performance of shell and tube heat exchangers, the advantages of using helical baffles are pointed out. Then some relations for computation of correction factors of heat transfer and pressure drop coefficients are presented on the basis of developed method of Bell-Delaware. It is shown that the product of two correction factors of the "change in the cross flow characteristics" and "the turbulence enhancement", at about a 42-degree angle, reaches the maximum value about 1.4. By using those relations and on the basis of Rapid Design Algorithm, a relation is presented for helical baffles that relate the heat transfer coefficient directly to pressure drop and heat transfer area. Design method is presented by using of this relation.Finally a comparison is made between helical and segmental baffles in an industrial unit, and the effects of application of tube inserts are studied. In comparison with a unit with segmental baffles, it is found that the heat transfer coefficient was 36% higher and pressure drop was 10% lower in a system with helical baffles. Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 12 22 https://pr.ripi.ir/article_259_c1b792e78d15375febc4c62b403086e3.pdf Reviewing the Function of Atomiser PFN 182 for Using in FCC Pilot Plant text article 2013 per The conversion process of heavy hydrocarbons to the valuable products such as gasoline is an important operation in the oil refineries.One important process is the "Fluidized Catalytic Cracking" (FCC).Feed injection in FCC process has an important role in the selectivity and properties of the products.Performance of the feed injection system is dependent on the Atomizers.The size and contribution of the feed droplets for desirable reaction is very important. The larger droplets in compare with smaller droplets are evaporated in a longer time and it causes undesirable reactions such as thermal cracking. The PFN 182 Atomizer is designed at the engineering pilot plant department of RIPI for FCC pilot plant operation and for more investigations; the tests are performed by cold feeds (Water-Air and Gas oil- Nitrogen) for simulation.In these tests, the Particle Dynamic Analyzer (PDA) and Photography method for determination of droplet size and velocity are used satisfactorily Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 23 34 https://pr.ripi.ir/article_260_3774b09002782d65e28b6e06ebdc33f6.pdf Comparison Between SCC Behavior of 420 Martensitic and 316L Low Carbon Austenitic Stainless Steels text article 2013 per Behaviors of stress corrosion cracking (SCC)in martensitic stainless steel(AISI 420) and low carbon austenitic stainless steel (AISI 316L) have been compared under different conditions of temperature, environment (MgCl2), and strain rate. The results show that decreasing strain rate has detrimental effect on mechanical properties of both steels, including their strength and ductility. Fractography of samples reveals that crack progresses by joining of dimples in fracture surface in all samples of AISI 420 steel, except in the sample that tested at 1.1×10-6s-1 strain rate, wherein intergranular fracture has also been observed on fracture surface. Necking phenomenon is only observed in air-tested samples of AISI 316L steel, but the other ones show lower ductility. AISI 316L samples, which tested under MgCl2 environment, show a mixed fracture surface of intergranular and transgranular. Percent of transgranular fracture increases as strain rate decreases Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 35 44 https://pr.ripi.ir/article_261_ec79b0de7428dd146eac1a12d6bb3053.pdf The Effect of Gel Strength of Cement Slurry in Preventing Gas Migration text article 2013 per Previous research on annular gas flow has shown that the behavior of cement between its fluid and set states is the controlling factor that may allow gas entry. This transition phase of cement previously has not been recognized in slurry design since its importance was not fully understood and since test procedures for its definition has not been presented or establishedTo predict the occurrence of annular gas flow and to design cement slurries capable of helping to prevent annular gas flow, it is necessary to define the slurry characteristics at the beginning and the end of this transition period as well as the period of time of the transition state. Test techniques have been developed to study the start of this transition period. Additional tests have been conducted to define the condition of cement required to prevent gas entry. The test techniques developed to define this transition period of cement slurry are described. Numerous job variables such as pumping time, placement time, slurry composition, and circulating temperature and pressure were investigated to evaluate their influence on transition time. A method for using transition time and static gel strength (SGS) development data to help predicting annular gas flow and to evaluate annular gas flow control materials, is discussed Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 45 53 https://pr.ripi.ir/article_262_f9f340a620e9744c1758ccd889e579a9.pdf Identification and Analysis of Human Errors by PHEA Technique in Isomax Unit of an Oil Refinery text article 2013 per According to industrial accident's investigation 60 to 90% of all accidents have directly been caused by human error. In this study , which has been done in the Isomax unit of an oil refinery , totally 25 existing occupational tasks were reviewed by aid of the results produced from interviewing the workers , discussing with supervisors & line managers and considering all the past accident's reports .From all 25 , 10 tasks were selected as susceptible and critical to human error occurrences .All selected tasks were analyzed by Hierarchal Task Analysis.In the second stage , PHEA( Predictive Human Error Analysis) technique was used for predicting and extraction of human errors in the selected tasks .Apart from determination of identified error's type (action, checking , retrieval , selection, sequence and communication error), description of errors , the consequences of their occurrence and proper solutions for prevention and recovering from errors were developed and entered into PHEA worksheet . The performed PHEA technique was identified totally 161 errors in all 10 tasks .The type of identified errors were different and their number were, according to the sequence written in the pervious paragraph , 108 , 12 , 24 , 4 , 5 , and 8 respectively. some important of these errors which have had , according to the accidents occurring the past , high frequencies were : the task was not done , too much done , too early or too late was done , has been done in different sequence and … .Finally for preventing and recovering from the identified errors some proper solutions, particularly in the area of hardware change in equipment design , have been proposed : labeling of equipments , making the colure pumps or switches different with each other , installing acoustic telephone booths in the site and … . Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 54 62 https://pr.ripi.ir/article_263_720f1974cba705049a0189f74abed9f2.pdf Determination of Operating Point of Oil Wells by Fluid Flow Modeling Through Reservoir and Well text article 2013 per Predicting the relationship between the flow rate and the pressure drop performance in the reservoir is very important for continuous production optimization in the field. An inflow performance relationship (IPR) model is typically used for this task. IPR models allow us to consider various operating conditions; determine the optimum production scheme, and design production equipment and artificial lift systems. IPR modeling (inflow) can be combined with tubing analysis (outflow) using "nodal analysis" techniques which allow us to monitor well flow rate and to choose the proper remedial treatment options to restore optimum well performance. In this work we use Vogel-type correlation for predicting Inflow Performance and Aziz-Govier-Fogarasi two phase flow relationship to predict Outflow Performance. Combination of an Inflow and Outflow (a curve reflecting the tubing performance) curves identifies an operating point of wells. Comparison of predicting results and results obtained from ECLLIPSE-VFPi software indicates a good ability of proposed model. Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 63 75 https://pr.ripi.ir/article_264_52a72e793119671f6d8133784f57b8c9.pdf The Study of Effect of Confining Pressure on Electrical Resistivity of Hydrocarbon Reservoirs Rocks text article 2013 per The Electrical resistivity of hydrocarbon reservoir rocks is an important parameters in the calculation of water and oil saturation percent in both carbonate and sandstone reservoir rocks.In this regard, most studies have concentrated on the Confining pressure on cementation factor and electrical resistivity in sandstone reservoir rocks. In this study the effect of confining pressure on cementation factor and electrical resistivity of different textures carbonate and sandstone rocks is evaluated Journal of Petroleum Research پژوهشگاه صنعت نفت 2345-2900 15 v. 52 no. 2013 76 80 https://pr.ripi.ir/article_265_c8a0c6a21b068ef2ff307c3ae6792af0.pdf


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From John Quincy Adams to Louisa Catherine Johnson Adams, 28 August 1804
Quincy 28. August 1804.
Two days ago, I wrote you my best friend, expressing great anxiety at not having heard from you for almost a month—I therefore now add a line to mention that I received last evening your two letters of the 5th: and 12th: of this month; by the latter of which it appears that you had again been a day or two longer than usual without hearing from me—I have never failed to write you every week, but our Post-Offices somewhere or other are very negligent or careless—It is always most advisable for our own comfort to make allowances of this kind, and I have generally done it.—My concern has been the greater because from your letters I have found the very precarious and infirm health of both our children, which excited alarm, and made the suspension of intelligence from you more distressing—Blessings upon Providence that my apprehensions were groundless—And may we all meet again soon in perfect health.
I am this morning going into Boston where I shall endeavour to procure and enclose to you a $50 bill—I was yesterday at Dr: Warren's at Jamaica Plains. His Son was there with his wife, who enquired after you—She promises shortly to give another Citizen to the Commonwealth.
Your's as at all times.
Boston 28. Augt:
Since coming into Town I have received your kind letter of the 14th: and rejoyce with exceeding joy, to learn that both you and the children were so well.—I must close this letter immediately, having no time to write further by this Post; but will reply more at length to your remarks ere long.
Your's faithfully,
I enclose you a bill for $50.
MHi: Adams Papers.


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'No problem'
Carlo Ancelotti has admitted that it wouldn't be a problem for him if Chelsea sacked him at the end of the season, after a season in which the Blues have largely disappointed.
Many now believe that the Italian will be booted out of the club after what will be only Chelsea's third trophy-less season, and it looks as though he will be heading for Roma, the team with which he had some of his best years, specifically the 1983 Scudetto. However he doesn't appeared too bothered by the notion of being sacked, probably because the club will have to pay out on yet another contract for a fired manager.
'I don't know what my future is,' he said. 'At the end of the season, I think the club can decide if they want me to continue or if they want to change. If they are not happy, they can change without problem. This is not a problem for me.
'Last year is the past. Everyone was happy to win the Double last year but this is the past. Obviously, this season was not a good season for us but now we have seven games.
'To speak now about which kind of change the club wants to do for next season about a new transfer or my future is not the right time. Every one of us has to try to do the best for the left seven games. After that, in the summer, we can speak about this. But to speak now is not the right time.'


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Mazars Vietnam Tax and Legal Updates October 2015
We are pleased to present you our Vietnam Legal and Tax Update for October 2015. In this edition, we highlight the following breaking news:
On 1 September 2015, The General Department of Taxation ("GDT") issued Decision No. 1574/2015/QD-TCT and Decision No. 1575/2015/QD-TCT on the official establishment of Transfer Pricing Inspection Departments at both the GDT and provincial tax department level, including Hanoi, Binh Duong, Dong Nai and Ho Chi Minh City.


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holistic skincare rituals to elevate skin, spirit and mind.
made with organic ingredients, Ōna Organics is a line of self care rituals influenced by the wisdom and healing of ancient Ayurvedic and eastern medicine. Each product both nurtures the physical body and uplifts the spirit and mind.Never tested on animals. Formulated without parabens, petroleum, propylene or butylene glycol, sodium lauryl sulfates, pesticides, phthalates, artificial dyes, or synthetic fragrances. *A portion of all sales is donated to the American Civil Liberties Union*
Hero Ingredients
rosehip oil
Harvested from the seeds of the Chilean rose bushes and rich in vitamins A and C, rosehip oil is a potent plant based retinoid. The elements of rosehip are known to correct dark spots, reduce hyperpigmentation, diminish fine lines and wrinkles and prevent skin congestion.
Moringa Seed Oil
Moringa seed oil, beloved for its high concentrations of omegas 3, 6, & 9, is a hydrating, rejuvenating, and deeply purifying oil. The small molecule size of moringa oil allows for quick absorption multi layer penetrate for long lasting effects.
A few benefits of moringa seed oil include: neutralizing free radicals, purifying deep within pores, preventing and reversing sun damage, slowing premature aging, soothing inflammation, and hydrating deep below skin's surface for a glow that radiates from within.
ylang ylang
Ylang Ylang's benefits extend beyond the body to the emotions of the spirit. The toning properties of this oil soften and balance the skin while removing impurities and preventing blemishes. Ylang Ylang balances energy, enhances spiritual attunement, and elevates mood.
Black Seed
Used by Cleopatra, Black Seed Oil naturally reduces redness and helps to clear congested skin. A deeply mineralizing oil, full of calcium, potassium, magnesium, zinc, & Vitamin B3, Black Seed Oil provides the necessary nutrition for skin clarity, recovery, and repair.