text:
KNOXVILLE — Decades of weapons production and base operations have left the U.S. Department of Defense (DOD) with a legacy of as many as 3,000 sites contaminated with highly toxic substances.
University of Tennessee Research Professor Jack Parker and Peter Kitanidis of Stanford University have been awarded $1.3 million over three years to find the best methods to analyze and clean up the sites effectively while keeping costs to a minimum.
Parker is a member of UT's Institute for a Secure and Sustainable Environment (ISSE) and Department of Civil and Environmental Engineering.
Their work will look specifically at substances known as dense non-aqueous phase liquids (DNAPLs). DNAPLs are among the more troublesome — and costly — toxic substances to remediate, and contamination may be linked to human health effects, including birth defects and cancer.
Parker and Kitanidis received the award from DOD's Strategic Environmental Research and Development Program. The methodology will be field-tested at Hill and Dover Air Force bases, located in Utah and Delaware, respectively.
Aleisa Bloom, group leader of the DOD Base Technical Support Group at Oak Ridge National Laboratory, and Kyle Gorder, project manager with the Hill Air Force Base Environmental Restoration Branch, will assist with the project.
Once the project is completed, the research group's cost-optimization methods can be applied at the nation's other DNAPL-contaminated sites, which include more than half of the Environmental Protection Agency's Superfund sites.
"The history of DNAPL site remediation over the last 30 years can best be described as the history of serial underestimation of cleanup costs," said Parker.
The project aims to produce comprehensive methods and computational tools for making cost-effective decisions on how to understand a polluted site — a process called characterization — and meet the DOD's cleanup goals.
"This project will focus specifically on optimal management of DNAPL-contaminated sites, which pose a major problem at many DOD facilities," said Way Kuo, dean of the UT College of Engineering. "The ability to apply and evaluate these methods and computational tools at Hill and Dover Air Force bases will be of direct and immediate benefit."
Kuo said the study also may lead to conclusions applicable to other national policy issues, such as which approaches make most sense in the real world of complex and hard-to-characterize sites.
Costs for cleaning up these sites easily can run in tens of millions of dollars, with larger sites costing many times more, said Randall Gentry, ISSE director and associate professor in UT's Department of Civil and Environmental Engineering.
"If Parker's methodology achieves even modest cost reductions, cumulative savings to the federal government can run into the billions of dollars," said Gentry.
Current remediation technologies for DNAPL contamination of soil and water include, among other approaches, chemical and thermal treatment, enhanced microbial degradation, extraction with surfactants, treatment of extracted groundwater, monitored natural attenuation and use of various containment methods to limit further migration.
DNAPLs, which include well-known chemicals such as creosote, coal tar and PCBs, saw widespread use beginning in the mid-20th century and continuing until the 1980s, when monitoring revealed significant contamination of groundwater.
Love Canal, a neighborhood of the city of Niagara Falls, N.Y., has become synonymous with DNAPL contamination. The 10-square-block residential area — home to nearly 1,000 families — surrounded an abandoned landfill used by a chemical company as a dumping ground for thousands of tons of various hazardous wastes. The neighborhood, contaminated with DNAPLs and other toxic substances, ultimately was declared a Superfund site and evacuated.
Jay Mayfield (865-974-9409, firstname.lastname@example.com)
Jack Parker (865-974-7718, firstname.lastname@example.com)


text:
About Me:
A friendly "hello" to every Beatles Fan and welcome on my wall! I like the Beatles since ever, but I became an obsessed in March 2009! My favourite hobby is listen to their great music and read books about them! I've got a lot of books: - A Hard Day's Write - The Beatles' London - You Never Give Me Your Money - Revolution in the Head - The Love You Make - Beatlology - Can't Buy Me Love - The Best of Beatles Book - Across the Universe - The Day John Met Paul - The Beatles Anthology - Liddypool - All You Need Is Ears - Beatlesongs - The Beatles come to America - The Mammoth Book of the Beatles - The Beatles Anthology - The Beatles Way - The Beatles UK Tours 1963-1965 - Images of the Beatles: Photographs from the Daily Mail - The Beatles: Inside the Only Lonely Hearts Club Band And I think that's all, if I haven't forgot one... Anyway, I just don't understand how some people can't fall in love with them, or say that there are bands that are better than the Beatles... I saw all their films, and my favourite is absolutely "A Hard Day's Night", 'cause I'm so in love with their sense of humour XD Their music? It's simply fantastic, from the early years to the psychedelic ad later years! Other people think I'm crazy 'cause I listen to the Beatles and they say that they're old and crappy, but I don't care :) They prefer listening to crap music like rap, heavy metal and such bad stuff, just grotty XD I've found a lot of friends here on this wonderful website, and finally somebody who understands me! A big kiss to all Beatles obsessed! By marydean <3
Favourite Track:
I Saw Her Standing There (PPM)
Tell us why:
HAPPY 73rd BIRTHDAY JOHN! I miss you so much and I'll never forget you <3 This is absolutely one of my favourite Beatles songs EVER! Every time I listen to it, I just feel like moving and dancing! Impossible to keep still when this song is playing :D I miss you so much John and George... You've gone away too soon :'( But I know, both of you are in a better place right now. You'll always be in my heart ♥ You're a Beatles obsessed if: 1. You saw all their films 2. You frame all their posters like important portraits 3. You run through the house shouting: "GOO GOO G'JOOB!!!" 4. You want to be Lucy in the sky 5. You love when the Beatles shout in their rock songs 6. You want to buy all their instruments 7. You watch over and over the film Help! and never get bored of it 8. You love the scene in the bath or the fight in the house of Help! 9. You LOL when you hear shout: "KAILIIIIIIII!!!" 10. You smile when you see a photo in which they have a lot of fun 11. You love the scene where they're playing on the field in A Hard Days Night 12. You always talk to the people about the Beatles even though they get bored 13. You want to live in a Yellow Submarine 14. You want to visit all the places where they have been (London, Liverpool, Hamburg, New York...) 15. You want a house that is identic of the Beatles' house in Help! 16. You pretend an autograph of all four even though John and George aren't alive 17. Your biggest wish is to live in the 60's and go in all their concerts 18. You would have been one of the stewardesses who served the Fab Four during one of their flight 19. You know at least 5 verses of each Beatles song 20. Your mp3 is full of Beatles songs 21. You can't stay a single day without listening their songs 22. You want to build a "Cavern" in your town 23. You want to build a hotel in your town called "Help!", "A Hard Days Night", "Abbey Road", "The Cavern", "A Day In The Life", ... 24. You get angry when you hear a bad critic about the Beatles 25. (added by ivegotaholeinmypocket) You hear someone who says something that is very similar to a part of a Beatles song or a phrase that the Beatles said, then you laugh and no one understands 26. (added by beatlesobsessed4) You hum one of the Beatles' songs when someone mentions something that has to do with the lyrics of one of their songs 27. (added by mrspaulie) 99% of your vocabulary is just repeating quotes of the beatles 28. (added by LetThereBe_BeatlesForever) Whenever you see any Beatles merchandise (a shirt, poster, magnet, cup, or even a keychain), you actually YELL at the person next to you, even if its a stranger, and you say, "I HAVE TO HAVE IT!!!" and it never works most of the times 29. (added by NothingIsReal909) You think the Beatles are still super hot, even in their old age This list has been created by marydean I hope you have enjoyed this list... Peace and Love! :D (COPY AND PASTE IF YOU'RE A BEATLES OBSESSED)
Favourite Album:
A Hard Day's Night
Tell us why:
I think I don't have a real favourite album. In this period, I love this one so much because of the movie. I love putting it on my turntable and sing along with my sister ;) I can't get enough of it ♥

subset: commoncrawl


text:
Just as the Republican primaries were heating up, Erich Origen of Oakland, Calif., was talking politics with a friend, as he likes to do, when he found himself saying, "Don't let the Republican drive the bus!"
Things immediately clicked: He'd just come up with the perfect title for a political parody of cartoonist Mo Willems' beloved children's classic Don't Let the Pigeon Drive the Bus.
In Willems' book, a cajoling pigeon who desperately wants to drive a bus throws a toddler-style tantrum. Origen figured he could twist this story and make the bird a Republican who desperately wants to drive the bus—i.e., run the country.
The fact that Origen had this stroke of genius isn't surprising. In 2008 he partnered with his friend Gan Golan and co-authored the New York Times bestseller Goodnight Bush, a parody of the children's classic Goodnight Moon that was built around the end of the Bush administration. Also, Origen is the father of a 6-year-old boy and has seen a few limb-flailing tantrums. He has also read his son Willems' book countless times.
That day Origen started mapping out a book aimed at taking on the Republican machine. He soon reached out to L.A.-based Golan, and the two decided to team up once again.
Within a month Origen and Golan had a contract with Ten Speed Press. Don't Let the Republican Drive the Bus hit bookstore shelves this month to coincide with the 2012 presidential election. The book's Facebook page already has more than 2,000 fans. The Republicans aren't the only ones to be attacked by a children's book parody. Loren Spivack's The New Democrat parodied the Obama Administration and was based on a famous children's book
Don't Let the Republican Drive the Bus is a fun, witty book starring a hyper-conservative vulture, named Birdbrain, who more than anything wants to drive the bus (even though he hates public transit—actually, he hates anything with the word public in it, including public libraries, public parks, public radio…).
"We decided on the vulture long before Rick Perry called Romney a vulture capitalist," Origen says. "The vulture captures the casual viciousness of the Republican species and the glib way they consume other people's lives and prey on people."
Throughout the book, the vulture tries to convince the reader that he should drive the bus by promising to give tax breaks, cut entitlements and run over the unions, teachers, firefighters… Holding an "edited" copy of the New Testament, he threatens, "We're all going straight to hell unless you let me drive the bus!"
Is this political parody for kids? Origen has read it to his own son but thinks it's better suited to adults and older kids. "It's pretty clean. Nothing too inappropriate but a lot of the political references will go over kids' heads," he says.
Instead Origen sees the book appealing to "anyone who is weary of the constant stress of the election and needs some comic relief."
Don't miss: Bay Area locals can catch Erich Origen dressed as a vulture and reading from Don't Let the Republican Drive the Bus at the Book Passage at San Francisco's Ferry Building on August 25 at 11 a.m.


text:
by Paul Scott, Volunteer Watershed Ambassador
Earth Day is upon us! This is the time to ponder our relationship with our one and only planet. In this regard a major force for me has been Mt. Tamalpais, the "crown jewel" being MMWD's watershed lands.
The Mt. Tamalpais Watershed consists of five reservoirs and primarily the north-facing slopes of the mountain that shed rainwater into them. These "lakes" have been here long enough that they are now a focal point for the diversity of flora and fauna found here. Camping, hunting, swimming, and boating are a no-no and cars have very limited access, so it's an oasis of sorts for natural processes to occur with minimal human disruption. While the "purpose" of these lands is to provide clean drinking water, requiring wise ecological practices, we are also blessed with their biodiversity and many recreational opportunities.
The natural resources staff work out of Sky Oaks Watershed Headquarters located in the hills above Fairfax and in close proximity to three of the reservoirs. Their volunteer program offers abundant opportunity for young and old, all geared toward environmental education, wise resource management, and furthering community spirit. As a volunteer and near-daily visitor to the watershed lands myself, I see folks come to visit with smiles on their faces. Many of them are "regulars" who tell me they feel the same way I do about the area—it is a place of peace and sanctuary. I'm amazed how many come from other countries, but I'm most surprised when I meet local people who had no idea all this was here.
Come develop your relationship with your watershed—for Earth Day and any day. Experience a fine example of how humans can make use of natural resources in an intelligent and sympathetic manner for everything and everyone to share.


text:
Wadsworth was the publisher who issued Looking Out, Looking In, written by Ronald B Adler and Russell F Proctor II. Published in 2010, this is the 13th edition of the text book. If you want to buy Looking Out, Looking In online, you are in the best place to do so. We can give you discounted and affordable prices for Looking Out, Looking In used editions such as this. Previously owned copies mean you get the best deal while still investing in the same material you would get in a brand new copy. For the cheapest prices you can find, shop with us today. Adler, Ronald B. is the author of 'Looking Out, Looking In', published 2010 under ISBN 9780495796213 and ISBN 0495796212.[read more]
{{post.questionOneAnswer|unescape}} {{post.questionTwoAnswer|unescape}}[read more]
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text:
So sweet and smiley
So nice and warm-hearted
The strengths of a person,
So simply one-sided.
Their deeds and accomplishments
Their daring and bravery.
But their secrets and struggles,
Still kept in slavery.
The aches and the pains
The failures and bleakness
All kept inside,
A basket of weakness.
The lies shroud out
Any hope that you hold.
Crushing, destroying
The misery unfolds.
It must spill out,
It must be told.
The pain can't hide,
Can no longer withhold
To tell a friend,
And shed some tears.
Release it all,
And calm your fears.
Not alone in all the muddle.
Not alone in the fight.
Many know the rugged path
And how it ends so bright.
The deeper each one probes the heart,
A bond there is to find.
Growing ever stronger,
And being ever refined.
For Christ said,
"My grace is sufficient for thee,
My power made perfect in weakness."
Oh, the wonderful love of a Savior as He.
A basketful of weakness
Made strong through the Blood.
So perfect in splendor,
Overflows as a flood.
Oh, thank God,
I'm a basketful of weakness.
And he said unto me, My grace is sufficient for thee: for my strength is made perfect in weakness. Most gladly therefore will I rather glory in my infirmities, that the power of Christ may rest upon me.
~2 Corinthians 12:9


text:
Re: Re: [MathGroup]: Descriptive headings
- To: mathgroup at smc.vnet.net
- Subject: [mg51987] Re: [mg51968] Re: [MathGroup]: Descriptive headings
- From: DrBob <drbob at bigfoot.com>
- Date: Sat, 6 Nov 2004 02:08:07 -0500 (EST)
- References: <firstname.lastname@example.com>
- Reply-to: drbob at bigfoot.com
- Sender: owner-wri-mathgroup at wolfram.com
I think the moderator does a great job already; don't mess with it. Bobby On Fri, 5 Nov 2004 03:21:05 -0500 (EST), Steven M. Christensen <steve at smc.vnet.net> wrote: > I want to take the opportunity to reply to Paul's suggestion in > as much detail as possible. > > I am sorry I was not at the event at the Wolfram Technology > Conference when this was discussed. > > First, here are the steps I take each day to moderate this group. > Figuring out where in these steps to put in categorization would need > to fit into this. > > 1. I get perhaps 2500-3000 emails a day, every day. Of these, perhaps > 500 are not spam. Because the Mathgroup addresses are easily found > by spammers, there is no way around getting a lot of spam. > Further, because MathGroup users often, unfortunately, > send html email or other attachments, maybe 10-20 of their mails get > filtered by my, fairly sophisticated but not perfect, spam filters into > my spam folder. > > 2. Of the 500 good emails that get past my spam filters, I then have to > filter out those mails that are for Mathgroup. Then, I have to > go through the spam folder to find any MathGroup posts that might be > there. So,there are usually about 70 emails relevant to MathGroup. > Some, maybe 10 do not follow the rules - flames, licensing questions, > discussions of other systems, really trivial items, totally non-Mathematica > related. In the end, there are 30-60 emails to read in more detail. > > 3. Once I decide that the posts are OK, I run them through a number of > UNIX scripts and do some more editing to take out unneeded mail headers > etc. > > 4. Then the mails are run through scripts that send them to the > newsgroup and the mailing list. One of the scripts adds the > [mg ... ] numbers to the Subject line of the mail that goes to > the mailing list. Note that the [ ] are really needed. Suppose > you just put Statistics in the Subject line, mail filters might > not always know how to do the filtering, whereas [Statistics] > is easier to filter. > > This process takes from 1-3 hours typically, depending on the > number of emails, their complexity, etc. > > So, the questions are, when during this process would categorisation > take place? What would it look like? Who would do it? How would > it effect mail and newsgroup readers? > > I think it would be a bad idea to put things like [Statistics] in > the Subject line. Would newsgroup and mail readers be able to > thread such Subject lines? It might be better to put it in something > like an X-Category mail header, but I am not sure that all readers > could handle this. Personally, I think they would just make the > Subject lines longer and harder to read. > > Who is going to do the categorisation? I know a lot about > Mathematica and mathematics, but certainly not enough to figure > out what every message best fits into. If I make a poor selection > and a message has gone out it is virtually impossible to re-do > the categorization in the newsgroups, mailing list, google group > listings, archives, etc. Search therefore becomes inaccurate > very quickly. What if someone disagrees with my selections? > How much time will this add to moderation? > > If others select the categories to help me out, that will just > delay moderation. Maybe, we can urge the person who originally > writes the message to select a category, but how does a new user > know what category to pick? What if a users forgets to include > a categorisation? > > Is someone going to go back and categorise the 51,000 messages that > are already in the archive? > > The simplest thing to do would be to have some group that is willing > categorise the posts once they get into the Wolfram Research > archive only. Then search could be done fairly easily. > > This sort of categorisation may be done in other newsgroups, but > I have not seen it. > > I am open to suggestions and comments, but I frankly this this > is going to be a very difficult process to do. > > Steve Christensen > > > Hi all, and especially Steve Christensen: > > At the recent Wolfram Technology Conference in Champaign, Luc Barthelet > <lucb at ea.com>, a regular user of MathGroup suggested that it would be > good if all postings to MathGroup included a categorisation in their > header, e.g. > > Newbies, Graphics, Functions, Programming, Statistics, Teaching, > Integration, Numerics, Symbolic Algebra, Special Functions, ... > > so a Subject line might take the form > > [Statistics]: How to fit to an elliptical function? > > (not sure if the [ ] are required or useful). In this way, sorting by > Subject would be easier. Of course, it's not always easy to do such a > categorisation, and they may change with time (as a problem stated as a > Numerics might end up being solved using Symbolic Algebra). > Nevertheless, I think such a change would be very useful. It should also > help when doing searches on MathGroup archives. > > Cheers, > Paul > -- DrBob at bigfoot.com www.eclecticdreams.net
- References:
- Re: [MathGroup]: Descriptive headings
- From: "Steven M. Christensen" <firstname.lastname@example.com>
- Re: [MathGroup]: Descriptive headings


text:
"Like a fine wine, this series just keeps getting better with age." (TOP PICK!)Kenyon, Sherrilyn is the author of 'Sins of the Night', published 2005 under ISBN 9780312934323 and ISBN 0312934327.[read more]
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Search using the fields below
Pregnancy & Childbirth Home
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Calculating a Due Date
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Pregnancy Overview
Anatomy: Fetus in Utero
The First Trimester (0 - 12 Weeks)
The Second Trimester (12 - 24 Weeks)
The Third Trimester (24 - 40 Weeks)
The Pregnant Mother
Hormones During Pregnancy
Weight Gain During Pregnancy
Nutrition During Pregnancy
Exercise During Pregnancy
Work and Pregnancy
Sex During Pregnancy
Sleeping During Pregnancy
Multiple Pregnancy
Overview of Multiple Pregnancy
Symptoms and Diagnosis of Multiple Pregnancy
Complications of Multiple Pregnancy
Care and Management of Multiple Pregnancy
Newborn Multiples
Common Discomforts of Pregnancy
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Illegal Drug Use and Pregnancy
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Warning Signs During Pregnancy
Complications of Pregnancy
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Care of the Baby in the Delivery Room
Postpartum Care
Caring for the Mother: Physically and Emotionally
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Our web site is designed to provide general information to educate users about programs and services, which may be available through our hospitals. The web site is not intended to provide medical advice nor should the information be used to attempt to determine the presence, absence or severity of any illness or medical condition which may be perceived or experienced by the user of this site. If you have or suspect you may have an illness or condition which you believe requires medical attention, we recommend you call your primary care physician. If you believe you are experiencing a medical emergency please call "911" (or your local medical emergency number) or seek immediate care from the nearest hospital Emergency Department. The provision of information to users of this web site is not intended as an inducement or to otherwise influence a person's decision to order or receive any item or service from a particular provider, practitioner or supplier that is reimbursable under Medicare, a state healthcare program (e.g., AHCCS) or any other healthcare plan.
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text:
The Fedora Project recently re-signed all of its packages with a new key. Background details regarding the key change are found here. This page exists to aide users in the transition to the newly signed content and further updates for Fedora 8 and Fedora 9.
What is happening?
All of the existing Fedora 8 and Fedora 9 released packages and updates are to be re-signed with new GPG keys. The newly signed content will be placed in new directories on the mirrors and new fedora-release packages will be issued to the old locations signed with the old key that reference these new locations and the new GPG keys.
Fedora treats the security and trust of its users very carefully. As such we would like to have zero doubt that the packages we offer are in fact from Fedora. Since we cannot in good faith continue to use the previously used GPG signing key, we have created new keys. The transition fedora-release packages (and PackageKit updates) are signed with the old key so that existing users can install them automatically given pre-existing trust in the old key. These should be the last packages ever signed with the old keys.
The resigning is happening in to phases. Phase 1 consists of resigning all of the published Fedora 8 and Fedora 9 updates and testing updates, as well as the pending updates. Phase 2 consists of resigning all the release packages for Fedora 8 and Fedora 9. Phase 1 is now complete and Phase 2 is progressing. In order to get important updates to users, we are enabling the Fedora 8 and Fedora 9 update flow now that Phase 1 is done.
A page detailing the steps involved with resigning all the Fedora 8 and 9 content exists here. Efforts are being made to keep end user interaction to a bare minimum and hopefully it can be a completely seamless process to end users.
What do I have to do?
Apply the next set of updates you see available. Then apply any further updates you see, verifying and importing the new GPG key along the way as prompted by your update software. That's it.
What if something goes wrong?
If your update software fails along the way here are some manual steps you can take to update yourself.
Install new fedora-release
Fedora 8
- Download the updated and signed fedora-release package.
- Verify that the package sha1sum matches 9a684ad36f4c1f49df7c569d5990d00f7da2cb9c
- Install the package via rpm
Fedora 9
- Download the updated and signed fedora-release package.
- Verify that the package sha1sum matches 259165485c16d39904200b069873967e3eb5fa6e
- Install the package via rpm
Import the new key
- Verify and import the new GPG key (/etc/pki/rpm-gpg/RPM-GPG-KEY-fedora-8-and-9) per [ https://fedoraproject.org/keys https://fedoraproject.org/keys ].
- Use your update tool to get and install any new updates from the new location
As questions come up throughout the Fedora community they will be posted and answered here. The discussion tab is also available for questions or comments.
If you wish to contact those involved with this process, you can find us on IRC on freenode network, #fedora-admin channel.


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The DT-3348 Professional True RMS Clamp Meter provides accurate AC/DC Current, Voltage and Wattage readings regardless of waveforms. This meter can be used in most industrial and commercial applications where non-linear loads distort the Current or Voltage waveform. Learn More
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text:
Significantly, the team was able to mobilize their newly gained understanding to target "addiction" pathways in the model mice, resulting in rapid and complete eradication of the cancer, which is usually fatal and resistant to conventional chemotherapy.
Oncogene addiction refers to the curious phenomenon that cancer cells, despite harboring many genetic alterations, can remain dependent on the continuing expression of a single aberrant, cancer-promoting gene – an oncogene. In this case, the gene in question, called MLL, has long been implicated in human cancers of the blood. In AML, as a result of a genetic anomaly, the protein expressed by the MLL gene fuses with another protein, to form a fusion oncoprotein called MLL-AF9. It is this protein to which AML cancer cells are "addicted."
"The crucial questions are what MLL-AF9 enables cancer cells to do, and how we might intervene to suppress these effects – in other words, how to use our knowledge of the mechanism behind the cancer cell's addiction for developing highly specific anti-cancer therapies.," says CSHL Adjunct Professor and HHMI Investigator Scott W. Lowe, who directed the research, which is reported in a paper that appears August 1 in the journal Genes & Development. "Until now, we've not been able to answer these questions in living animals."
The team's research demonstrated that MLL-AF9 enforces a cellular program that enables blood cells to keep renewing themselves, rather than progressing through the usual stages of cellular life, and eventually dying. While this property of aberrant self-renewal has been a known characteristic of leukemia cells for many years, Lowe and his CSHL colleagues were able to decipher the underlying genetic program in unprecedented detail. The central player orchestrating these cancer-specific self-renewal programs was found to be Myb, a protein known to regulate normal blood cell production that previously also has been implicated in certain subtypes of leukemia.
"MLL-AF9 apparently 'hijacks' Myb to enforce a program of aberrant self-renewal," explains Amy Rappaport, who was a co-first author on the paper, with Johannes Zuber. The team also included Christopher Vakoc, a CSHL Fellow, among others. "The consequences of inhibiting Myb in established leukemia were striking," says Zuber. "Following Myb suppression, mouse leukemia cells invariably lost their aberrant self-renewal ability, resumed their normal cell fate, maturing into white blood cells, and eventually got eliminated." As a consequence, mice harboring this aggressive and chemotherapy-resistant form of AML were cured by inhibiting Myb. The protein's suppression had no adverse impact upon normal white blood cells.
To identify and study genes that are specifically required in cancer cells, the researchers took a systematic approach that demonstrates the power of a series of technological advances made by Lowe's group in concert with several other groups at CSHL. These advances play an important role in CSHL's new Cancer Therapeutic Initiative. The Initiative aims to rapidly identify new therapeutic targets and validate them in mouse models specific for genetic subtypes of human cancer.
In the paper published today, Lowe's team first implemented a rapid strategy to introduce common human AML mutations in mice so that they closely mimicked human AML, both in terms of symptoms and response to treatment. These genetically reprogrammed mice are called "mosaic mice." As a next step, the team used a genetic switch to inactivate the oncogene that gives rise to the "addictive" MLL-AF9 oncoprotein. When MLL-AF9 was suppressed in living mice, the cancers shrank and were soon eliminated altogether from all affected organs. This result confirmed the cancer cells' addiction to MLL-AF9, and provided a unique system to reveal the underlying genetic networks.
To further explore components of these networks, the team used RNA interference, or RNAi, an experimental tool to suppress gene function, which in prior work they had adapted for use in animal models. These recent advances now provide a means to switch off virtually any gene in an established cancer, and thereby enable the identification and evaluation of new potential drug targets. While the current study focused on the dramatic effects of suppressing Myb in AML, the approach validates a general method for understanding oncogene addiction in vivo that can be applied in other cancer types.
The RNA interference technique used in the experiments to block Myb is not applicable in humans, for a variety of still-daunting technical reasons. The hope is to find a small molecule that specifically targets the Myb protein, which can be the basis for a human drug. None has yet been developed, although the search is on.
But, says Lowe, "our results show that suppressing a single mediator of aberrant self-renewal can re-establish pre-existing cell-fate programs and eliminate aggressive AML. This suggests that pre-existing cell-fate programs remain hard-wired even in cancer cells, and raises our hope that agents that inhibit these programs will be less prone to resistance mechanisms that prevent targeted therapies from producing a lasting effect in other cancers."
"An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance" appears August 1 in Genes & Development. The authors are: Johannes Zuber, Amy R. Rappaport, Weijun Luo, Eric Wang, Chong Chen, Angelina V. Vaseva, Junwei Shi, Susann Weissmueller, Meredith J. Taylor, Martina Weissenboeck, Thomas G. Graeber, Scott C. Kogan, Christopher R. Vakoc and Scott W. Lowe. The paper is available online at: http://www.genesdev.org/cgi/doi/10.1101/gad.17269211.
This work was supported by a Specialized Center of Research Grant from the Leukemia and Lymphoma Society, the NIH, and generous gifts from the Don Monti Memorial Research Foundation. Other support was obtained from the German Research Foundation, the Andrew Seligson Memorial Fellowship at CSHL; the Barbara McClintock fellowship; the Leslie Rutherford Leukemia and Lymphoma Society Scholarship; the Cold Spring Harbor President's Council; and the Howard Hughes Medical Institute.
About CSHL
Founded in 1890, Cold Spring Harbor Laboratory (CSHL) has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. CSHL is ranked number one in the world by Thomson Reuters for impact of its research in molecular biology and genetics. The Laboratory has been home to eight Nobel Prize winners. Today, CSHL's multidisciplinary scientific community is more than 400 scientists strong and its Meetings & Courses program hosts more than 8,000 scientists from around the world each year. Tens of thousands more benefit from the research, reviews, and ideas published in journals and books distributed internationally by CSHL Press. The Laboratory's education arm also includes a graduate school and programs for undergraduates as well as middle and high school students and teachers. CSHL is a private, not-for-profit institution on the north shore of Long Island.
Written by: Peter Tarr, Senior Science Writer | [email protected] | 516-367-8455


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Cherie Czumak firstname.lastname@example.com wrote to me about Charles Cumber.
Charles CUMBER b. 1836 was her Great Grandfather — He was a quaker and attended the Ackworth school in Yorkshire (1845-1850) and was the ordinary seaman on the Dispatch.
He married Anna Maria Louisa TALLENT B. 1841 — they had one daughter Ethelinda CUMBER b.1860. In 1862 they all came to Canada (Toronto) and had several other children. His wife, Anna died about 1877-8. Charles then married her sister Mirian E. H. TALLENT on May 6, 1879 and they had two more children, the first of these two being her Grandfather Thomas Sharshaw CUMBER b. 11-29-1879


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As Eric Holder became on Thursday the first US attorney general ever to be cited for contempt of Congress, House members faced the possibility that their investigation of a botched federal gun-trafficking sting could become a racial flashpoint.
Black leaders have rallied around Attorney General Holder, and the Congressional Black Caucus walked out Thursday when the entire House voted 255 to 67 to pass a recommendation by the Oversight Committee to hold Holder in contempt, which could lay the groundwork for a criminal investigation.
Already, Holder had brought race into the debate over the Fast and Furious gun-running scandal. The House Oversight Committee's investigation was a way for Republicans to get at the president in part because "we're both African-American," he told The New York Times last year.
And Holder has pushed the envelope on race before, for example calling America "essentially a nation of cowards" for failing to debate race openly.
Now, the moves in Congress Thursday raise the specter of charges of a racial conspiracy by white Republicans against a black administration.
Some leaders, like the Rev. Al Sharpton, suggested that Republicans had "stopped and frisked" Holder to make an "example" out of a black man. House minority leader Nancy Pelosi opined the contempt vote is retribution for Holder's opposition to new voter ID laws that are seen as targeting minority voters in former Confederate states. MSNBC host Chris Matthews questioned whether the rancor of the contempt vote has an "ethnic" root.
The political showdown showcases a pattern that has emerged during the Obama presidency: supporters claim the opposition is racist, and critics dismiss the reaction as a knee-jerk casting of the "race card." But its real root, say some political analysts, is more in politics than race.
"The issue of how Obama and secondarily Eric Holder have been treated, and whether race plays into it, is not crazy in the sense that a lot of the early public demonstrations had racial tinges to them, and the fact that 15 percent of whites in Mississippi voted for Obama," says Cal Jillson, a political scientist at Southern Methodist University in Dallas. "But even though the Republicans have stated that their chief goal is to see that Obama is a one-term president, what we're seeing [with Fast and Furious] is not racial politics, it's partisan politics."
After a 16-month investigation, the House Oversight Committee says Holder is refusing to hand over 1,500 pages of documentation that it needs to figure out who knew about the program, and when. Holder has said making those communiqués public could put US agents at risk and cases in jeopardy, and President Obama stepped in to block the release of the documents by invoking executive privilege. A separate inspector general investigation into Fast and Furious is ongoing.
The debate in the House over holding Holder in contempt has broken down mostly along partisan lines, although 17 Democrats voted for the contempt order after the National Rifle Association warned that it would be grading lawmakers on the vote, claiming it's part of a broader Second Amendment issue.
Rep. Elijah Cummings of Maryland, the top Democrat on the Oversight Committee, said in a statement Thursday that the contempt move is "politicized and reckless," while conservatives say there are still disturbing questions about what higher-ups at the Department of Justice knew about a program that may have contributed to the deaths of hundreds of Mexicans and a US Border Patrol agent, Brian Terry.
But it's Republican Chairman Darrell Issa's relentless pursuit of Holder, even though he's admitted there's no evidence tying Holder or Mr. Obama directly to Fast and Furious, that has drawn criticism from minority leaders and activists.
"AG Holder was in essence 'stopped & frisked' without probable cause, and after he cooperated, he was made an example of," Mr. Sharpton writes on the Huffington Post. "What Issa just showed us is that no matter what our stature in this world, someone can easily try to 'put us in our place.' What could be more outrageous?"
Some suggest that casting Republicans as modern-day Klansmen on a hunt for an errant black man will awaken an apathetic minority voting bloc, which could be crucial to the Obama reelection. But conservatives suggest that won't work.
"There's nothing to prove anymore, and the Congressional Black Caucus may discover that their knee-jerk defense of Holder on racial grounds will not fly," writes William Bigelow, a columnist for the Big Government website. "If they take their ball and go home, they may find that no one wants to play with someone crying racism any more."
But Republicans, too, are aware that attacking an Obama cabinet minister with too much zeal can backfire. "It's hard to believe Republicans relish the idea of voters seeing them imprison the country's first African-American attorney general," writes Alex Koppelman in The New Yorker.
A US attorney in Washington will now decide whether to file charges against Holder.
It's partly Holder's outspoken, sometimes in-your-face views on race that have made him an appealing target for conservatives – more so even than Obama, who has treated the inevitable matters of race more carefully and deliberately, says Professor Jillson.
"The president has always tried to deal with it not just in a responsible way, but in a way that buries the sharpest edges of race, whereas other people are much less capable verbally of handling these things in a way that leave people comfortable," says Jillson.


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Judge Judy is heading to prime time this spring for a one-hour special, CBS announced Wednesday.
Airing Tuesday, May 20 (8/7c), Judge Judy Primetime will take a look at how Family Court Judge Judith Sheindlin became a household name. The special will also feature new cases and classic "Judyisms," her one-liners that have been parodied on Saturday Night Live and Jimmy Kimmel Live.
Killer hair: An analysis of creepy cuts
Judge Judy has been the top daytime courtroom program since its debut in 1996 and has since grown to become a global hit, airing in over 125 countries around the world.
Will you watch Judge Judy Primetime?
Watch Judge Judy share her thoughts on family and marriage here.(Full Disclosure: TVGuide.com is owned by CBS.)


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Bruce Walker
New American
August 19, 2012
The Canadian Medical Association, the largest association of doctors in Canada, has redefined human life. On August 15, as reported by LifeNews, delegates to the CMA's general council voted to pass "a resolution supporting the current wording of the Criminal Code which states that a child 'becomes a human being within the meaning of this Act when it has completely proceeded, in a living state, from the body of its mother.' "
The CMA resolution is intended to support the nation's criminal code, which defines an infant as a human being only after the infant is born.
Canadian Physicians for Life decried the action, calling it shameful and unethical. Dr. Will Johnston, president of that organization, said that "every Canadian doctor knows that the unborn child is a live human being…. CMA delegates worry about children not exercising enough or not wearing bicycle helmets, while over one hundred thousand children go missing from our playgrounds every year because they were killed by abortion."
Dr. John Shea of Canadian Physicians for Life said that the CMA should be "ashamed of themselves for failing to recognize when human life begins. The biological fact is what counts here, which is when the ovum and the sperm unite, a single-celled human organism is formed. Period. This organism is a human being, a person at the single-cell stage. From that point in time he or she has rights. Anybody who denies that fact is denying biological reality; they are lying."
That "biological reality" is denied in Canada by national statutes that prevent abortion from being considered the taking of human life. That it something that Conservative Member of Parliament Steve Woodworth sought to challenge in the House of Commons last February, when he asked for a special committee to consider when human life begins. Woodworth's motion does not have the support of his party's leader, Prime Minister Stephen Harper, who has pledged to vote against the motion when it comes up to a vote in the House of Commons.
For centuries, physicians have professed the Hippocratic Oath before being recognized in the medical community as physicians. The oath, a relatively brief statement of eight general pledges, includes as one of those pledges the following language:
I will give no deadly medicine to anyone if asked, nor suggest such counsel, and in like manner, I will not give a woman a pessary to produce abortion.
The Hippocratic Oath, however, has been altered. Now medical schools in America, reflecting the changed attitude towards abortion, have dropped completely the sentence quoted above.
In the United States, the American Medical Association has also moved away from a strongly pro-life position into an attitude of almost complete moral indifference toward abortion. In 1859, the AMA decried abortion as "the slaughter of countless children, such unwarranted destruction of human life." Twelve years later, in 1871, the AMA referred to abortion as "the work of destruction, the wholesale destruction of unborn infants." Yet by 1967, the euphemistic language began to refer to unborn children as something less than human life, and the AMA called abortion "the interruption of pregnancy; the induced termination of pregnancy." By 1970, the dehumanization of unborn children was essentially complete when abortion was simply called "a medical procedure."
The British Medical Association, a close international colleague of the American Medical Association and the Canadian Medical Association, in late June of this year showed that pro-life advocates can claim some victories, even in places such as Britain that have long had legalized abortion. The BMA passed a resolution saying that any woman seeking an abortion ought to receive counseling and that this counseling should not be given by an abortion clinic or the people performing the abortion.
Those familiar with the history of the 20th century know that the Nazis were passionate supporters of ending unwelcome or unwarranted and helpless human life. In fact, it was the Nazis who coined the term "Life Unworthy of Life." On June 8, 1943, Ernst Kaltenbrunner, the SS monster later executed at Nuremburg, ordered: "In the case of eastern female workers, pregnancy may be interrupted if desired. If a racially valuable result is to be expected, the abortion is to be denied … if not valuable, the abortion is to be granted." In fact, "encouraging and compelling abortion" was considered one of the crimes against humanity in the war crimes trials of Nazis.
If an association of medical professionals was giving the option of following in the footsteps of Hippocrates or following in the footsteps of Himmler, the decision would seem to be pretty easy.
This article was posted: Sunday, August 19, 2012 at 5:06 am


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Welcome to
The Dragon's List!
Health & Wellness
Your heart seesm to jump into your throat. It beats rapidly, increasing your blood pressure and breathing rate. Adrenalin is pumped into the system to deal with the crisis that will also affect energy output and reaction times. Your nervous system can respond radically enough to cause muscle spasms and partial paralysis. You could experience time dilation and a "tunnel" vision.
Application & Technique
If you, like many people, think that these beautiful forms are merely for demonstration, and useless for combat, you will be in for a surprise. In fact, they are what they are because of their combative function; they were never invented for decoration. Indeed, it is shameful if students merely perform them to please spectators. These patterns are more beautiful in their combat function than in their appearance.
Health & Wellness
Daoist breathing, also known as Reverse Breathing, is used to prepare the Qi for circulation, and its proper development is crucial. In Daoist breathing the normal movement of the lower abdomen is reversed during inhalation and exhalation.
Sifu Wong Kiew Kit is the fourth generation successor from the famous Shaolin Monastery of China, and a grandmaster of Shaolin Kungfu and Chi Kung. He received the "Qigong Master of the Year" award at the Second World Congress on Qigong held...
Who's Who In Kung Fu


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After tapping such beauties in recent seasons as David Beckham and, most recently, Megan Fox, Armani has named Rihanna as the face (and figure) of its fall ad campaign, WWD reports.
The pop star, who's got a pretty gorgeous look to back up the big vocals that made her famous, will front both the Emporio Armani Underwear and Armani Jeans spreads. The ads, which were apparently shot on location in New York by photographer Steven Klein, will debut in September.
Klein's steamy sensibility and Rihanna's fearlessness in front of the camera -- she's gone topless as a spokeswoman for Nivea and has made a sartorial name for herself putting her dancer's body in fierce costumes and various stages of undress -- should make for a provocative series of images.


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This is relentless and unforgiving...and I'm not talking about MrsF.
So bad that I'm cutting my mini-vacation short. I still don't have time for a full post so here are two items for you to read this morning.
ZH has been doing an excellent job chronicling the consistent, daily destruction. Here's the latest: https://www.zerohedge.com/news/2013-02-20/precious-metals-morning-slam-right-schedule
And here's someone who has noticed some of the same "anomolies" that I have: https://www.zerohedge.com/contributed/2013-02-20/curious-case-falling-gold-and-silver-prices
The charts, of course, look terrible. Having failed at hoped-for support, silver looks like $28 and gold, if $1580 fails, looks headed all the way back to the bottom of the 18-month range, near $1550.
This is all highly unusual and indicative of extreme manipulation and panic-level positioning. At the risk of sounding trite and reading like another KWN pumper, I must say it: THIS WILL PASS. THESE EXTREMES WILL BE RESOLVED SOON AND NEW UPLEGS WILL BEGIN. PLEASE BE PATIENT. THE FUNDAMENTALS ARE STRONGER THAN EVER AND PHYSICAL REALITIES WILL SOON REPLACE PAPER SHENANIGANS AS THE DRIVING FORCE BEHIND PRICE.
More later if possible.


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Customised your iPhone screen with your most unique possession: your DNA
How to proceed?
Choose the colour of your picture among the five ranges above and, in a few days, you will receive a DNA sample kit. After sending back your DNA, we perform your personnalised profile from your DNA. Two weeks later, you will receive by e-mail your personalised picture.
DNA portrait designed for iPhone wallpaper
Size : 320 x 480 px
Defintion : 160 dpi
Weignt : 120 Ko
Color : choice among 5 ranges
For gift orders, select the box marked "gift" to let the recipient choose the colour.
Click on the pictures to enlarge. .


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@jsbarrett Squirrel? Oh, it was just a mention of my name.
Well, I'm here now, so...um... good spot on the tracked logo. I thought it was actually painted on the ground. I see it slides a bit in the second one (nicely masked against the barn), but you have to look hard to see that so it was a good job. Probably not done with mocha. I'm going to say: AE 3D camera Tracker?
@Palacono You are correct! It was done with AE 3D camera Tracker! And yes, I did notice the logo the second time moving a little, and nice of you to notice the mask against the store!
Well you fooled me completely the first time, so I'm legally obligated to say something that shows I'm not completely out of touch.
Haha well hope to fool you again! XD
Balogna Man. Too much black, blah, blah, been said. @jsbarrett nailed it with mistakes. Those are how you learn and get better. The day I'm 100% happy with anything is the day I've become complacent.
On the positive side the shots you've shown are pretty sweet. Some of the flying is spectacular, the building jumping is pretty close (get a cast shadow in the overhead onto the roof and it'll be 10 times better), you've got lovely shockwave and energy effects, and that super slow mo explosion is a hell of an ambitious shot that works well. Text is suitably "Blockbuster. Overall it's great work.
It might be worth the re-edit to fill the black. Don't change anything else, just add in stuff. Especially the exchange dialog between the two characters, which could just be the shot that goes with the audio.
Lovely footage. Even knowing the logo was tracked in it's hard to spot. I probably would have been fooled.
If you take more corn maze footage (like you won't?) you need to start on a close overhead of someone, preferably two small happy kids, running joyfully along then rise up for the wide. Panning to buildings optional. I'd just go for the size of the corn maze. Maybe add a slow rotation in post... Totally add a slow rotation in post.
@Triem23 Glad you liked the Bologna Man TRAILER! Once again, I will remember the "to much black stuff" for the next trailer! I do not know what I was thinking! Lol
I was trying to get a cast shadow on the overhead roof scene, but I do not remember what happened, but I will try doing it for the film!
When I was editing the trailer, I thought about having one of the shots to be in that has the voice over, like you said, just didn't do it Next time though!
Glad you also liked the Pumpkins! originally I was not going to have the logo on the floor, I was not even thinking about it, but then I was like, you know I should put it there, and there you go!
I do not know If I will be taking more footage of the corn maze yet, I do not know what my boss wants me to film next, but if I do, I will probably do something like you said for sure!
Hey everyone!!! I know I have not posted in a while, but this is what I have been doing, and literally we did all this in about only two weeks!! So it is not the best, I wanted to add more details, and end it better, and fix the voices, but once again I stayed up till 3 in the morning trying to finish this video and upload it, before the contest was over, and I think I barely made it, just 5 min. before the submissions closed! I also had more light saber fighting, shot, but did not have enough time to edit it in time And this is taken from the bologna man series episode #3, which the full episode will come out sometime next year! Enjoy! (still working on the first episode!!)
Let me know what you all think!!
Very cool! That's definitely an ambitious project to pull off in two weeks, but I think you did really well.
Most of your effects were really nice. The main one that didn't work as well for me was the big energy ball that ended up blasting them against the trees. The concept worked, but the comp could've used more tweaking. It didn't feel as grounded in the scene as everything else.
Another one that I feel could've used more tweaking was the way that Bologna Man's saber fell off the body of Darth Whatshisname near the end. Instead of animating the saber falling off, it might've worked better to have the prop balanced on the guy's chest (perhaps with the help of an assistant and some fishing line) and just let it fall naturally, then clean it up in post.
The opening scene worked pretty well for me, but something about the comp makes it feel flat. It feels too much like everything is being lit by a light directly behind the camera, and even though there's a good bit of darkness to the scene, the highlights on all elements are nearly at the same level. I'm no live-action comp wizard by any stretch, but something could be done to improve the feeling of depth in the scene.
There was also too much camera shake in those opening shots for my taste. If you were trying to make the camera feel handheld, HitFilm's shake effect isn't the best way to go IMO. HitFilm has a tutorial that shows how to apply natural camera movement from one scene onto another, and might've been a more effective approach.
I can appreciate the amount of work it took to pull off both the sword and the physical battle. Yes there are things that at first look could have been refined for the sake of smoothness and continuity, however, it is way above anything that I could accomplish given a year to conceive, write, create props, film edit, create the VFX, Colorgrade and final print. So for me, well done.
I was also impressed that you were able to get Andrew Scott (Moriarty in Sherlock) to do the opening voice.
@jsbarrett Glad you liked it!!!
I agree with you on the energy ball effect, I think there were a couple things I could have done, but as I am going to say a lot, I did not have much time.
The Actors name for the sith's name is Nate, so we just decided to go with Darth Nater! XD But that is a great Idea, and I should have done that, wasn't thinking! And I was already using fishing line for some of the other shots, oh well.
I totally agree with you on the opening scene! I have scene tutorials on how to do the depth stuff, but never really tried it, but yea, it is a little flat.
And thanks for showing me this tutorial on camera shake, it is going to help for sure!! I guess I could have done less shake!
Thanks @jsbarrett for taking the time to share your thoughts, and helping me out!!!!
@BobDiMarzio Hey! Glad you liked it!! I appreciate it when people notice all the work! I could not have done it with the help of my family and friends!!! Plus the help from tutorials from amazing people, and places like this Forum!!!
It was very hard to get Andrew Scott to want to do the opening voice, but he agreed to do it for some free candy Lol He could have just said no, and waited for last night! Just kidding!
I am back with another ten second entry!! Please let me know what you all think!
Well done! Love the wave.
Hi people!!
It has been a little while, been really busy with work, but here is another video from sweet providence Farm!!! This time Christmas trees!!!
Please let me know what you all think Thanks!
@HIS_Films Loved the seque at 36 seconds from outside to indoor. And OMG I always wondered how they got that netting around trees. That is ingenious in it's obviousness. Of course, I am a sucker for drone footage; I think it looks so professional and Hollywood. You did a really good job. I kept trying to spot the VFX and couldn't, so that's the best you can ask for.
@tddavis Thank you for your kind words!! Glad to hear them!! Yea sometimes you wonder how things are done, and you think it is complex, but sometimes it is really simple Glad you liked it!!
Great Job. Nice smooth drone work. Nice transitions, great pacing I have to ask. Was that real snow fall or VFX snow fall?
@BobDiMarzio Hey!! Glad you enjoyed it!!
The snow that was falling was not real! I can't fly my drone in that weather! So that was VFX snow!
Well you fooled me.
If it was me, I would change only one thing. This is the music I hear in my head when I watch your video without sound.
I guess I'm showing my age. Sleigh Ride has traditionally been used with so many Winter/Christmas Videos, Commercials, Station bumpers for such a long time. I guess I instinctively expect it when I see something that could be first person Santa POV. I'm not sure I would have used it, Who am I kidding, yeah I would have used it.
Lol, I know what you mean! It is a great song, just came across carol of the bells Epic version, and I really liked it!!
@HIS_Films I started your Carol version and immediately the Tardis and the Doctor sprang to mind. That version is very Whovian! BTW, I also was fooled into thinking you flew your drone in a blizzard.
After Seeing TSO in concert a few years ago, Carol of the Bells has not been the same.
Overall, a really nice promo for the farm! I had a hunch the snow was added in post, but except for a few small hints that give away its true nature, it's quite effectively faked! Aside from that, there were a few things that stuck out:
Hey @jsbarrett glad you liked it for the most part, umm... so #1
Nce footage and good job with the edit and snowfall VFX it looked real to me . Just the music is off for me sounds like a clip from diehard a bit to dramatic for christmas trees


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The wiigee library
- allows you to define (train) your own arbitrary gestures,
- recognizes these gestures with high accuracy,
- offers an event-driven architecture with which you will be able to
- integrate the gesture-input as easy as common mouse-input.
wiigee utilizes state of the art probability theory-methods to deliver reliable results fast and efficient. Since it is still under development you are constantly invited to give feedback on your experience with the library and actively help to further improve it.


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In case you have some trouble to properly disconnect some client streams opened with stream_socket_server / stream_select you should give a try to stream_socket_shutdown.
<?php stream_socket_shutdown($clientStream,STREAM_SHUT_RDWR); ?>
fclose — 关闭一个已打开的文件指针
handle 指向的文件关闭。
文件指针必须有效,并且是通过 fopen() 或 fsockopen() 成功打开的。
Example #1 一个简单 fclose() 例子
$handle = fopen('somefile.txt', 'r');
In case you have some trouble to properly disconnect some client streams opened with stream_socket_server / stream_select you should give a try to stream_socket_shutdown.
<?php stream_socket_shutdown($clientStream,STREAM_SHUT_RDWR); ?>
It is a GOOD_THING to check the return value from fclose(), as some operating systems only flush file output on close, and can, therefore, return an error from fclose(). You can catch severe data-eating errors by doing this.
I learned this the hard way.
if you want to daysychain a filehandle through some functions and each function is allowed to close th file you might look in a following function first, if the handle is still valid.
Opening a file, there often will be used a code like
if (!$fh = fopen($filename, $mode)) return false;
But if you possably have closed the file and you want to check that, a smililar statement would not work.
DOES NOT WORK: if (!$fh) end_of_chain();
use beter: if (is_resource($fh)) end_of_chain();
In response to kumar mcmillan 'gotcha' note below, we get a different result on a W2K machine:
$file_pointer = fopen('textfile.dat', 'r');
echo '$file_pointer is resource = ' . (is_resource($file_pointer) ? 'true': 'false');
$file_pointer is resource = false
It is very important to make sure you clear any incoming packets out of the incoming buffer using fread() or some equivalent. Although you can call fclose() the socket does not actually shut down until the inbound packets have been cleared. This can lead to some confusion.
Generally, it's always a good idea to close a file when you're done with it. It's very easy for something to go wrong and corrupt a file that hasn't been closed properly. If you're concerned about efficiency, the overhead is negligible.
fclose() also clears any locks on the file, so if another process was being kept waiting for the lock to be cleared, fclose()ing will allow the other process to continue.
[Another "just-in-case" reason to habitually fclose() all files as soon as practical!]
Do not forget, if you are going to read the contents of the file which you have already written via fwrite() or else you have to close the file first.
Note that since PHP 5.3.2 fclose() no longer unlock open file descriptors at shutdown.


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A West Virginia resident is the third person to die from the rare hantavirus after staying at Yosemite National Park this summer, officials announced Thursday, as they raised to 22,000 the number of people who might have been exposed.
All told, eight people have contracted the mouse-borne disease after spending one or more nights at the popular park since June 10.
Seven of the infected people, including all who died, stayed in the "signature" tent cabins in Curry Village. The park service closed all 91 of those cabins last week while it investigates how to protect the public.
The remaining infected person stayed in several of Yosemite's High Sierra camps. Park employees are now attempting to contact the nearly 12,000 people who visited those areas this summer and urge them to seek immediate care if they develop symptoms, park ranger Scott Gediman said.
Park officials have also been seeking to get in touch with the 10,000 people from around the world who may have been exposed to the deadly virus by staying in the signature tent cabins since mid-June.
It can take up to six weeks for symptoms to develop. People initially may feel like they are getting the flu with fatigue, fever, chills and muscle aches. But after a few days, their health may deteriorate rapidly.
The disease is typically spread through the droppings or urine of infected deer mice.
The person who stayed in the High Sierra area "exhibited very mild symptoms," Gediman said. "He never was hospitalized, and he recovered."
That person stayed in tent cabins at Tuolumne Meadows Lodge, Merced Lake Camp, Sunrise High Sierra Camp and Vogelsang Camp, Gediman said. He also did some backpacking.
In addition to the West Virginia resident, others who died included a 37-year-old Alameda County man and a Pennsylvania resident.
The five who are recovering from the disease were all California residents. But because Yosemite has so many international visitors, the park service has put out a worldwide alert for doctors to be on the lookout for cases.
The signature tent cabins that have been the focal point of the investigation into how the disease is spreading have a double-walled design. The park decided to close those cabins before the busy Labor Day weekend after finding evidence of mouse activity in the gaps between the walls.
Some people have been canceling reservations to visit the park after hearing about the outbreak, but both the Ahwahnee and Yosemite Lodge were sold out over the Labor Day weekend, Gediman said.
A phone line set up for people to ask questions — 209-372-0822 — has been receiving 200 to 500 calls a day. It is open from 9 a.m. to 5 p.m. daily.
Since hantavirus pulmonary syndrome was identified in 1993, about 60 cases have been reported in California and 602 nationally.
About 20 percent of deer mice in the Sierra Nevada carry the virus.
Sandy Kleffman covers health. Contact her at 510-293-2478. Follow her at Twitter.com/skleffman.


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Portland Mushroom Company big winner at venture competition final
October 04, 2013
Portland Mushroom Company, the creation of three 2012 graduates of the College of Arts and Sciences, was the big winner in the final of Lewis & Clark's inaugural venture competition, held October 4 in a crowded Council Chamber.
Portland Mushroom Company, which uses sustainable, locally sourced practices and materials to grow high-end oyster mushrooms, was awarded $20,000 by the judges for use in expanding its operation. The team consists of Zachary Tobias BA '12, Ryan Bubriski BA '12, and Will Fortini BA '12.
The other winning team was RootED Recovery, a clinical mentoring program for adults with eating disorders. The program connects a network of care providers with eating-disorder sufferers to support them in their ongoing recovery. The team, made up of Alishia Blevins M.A. '12, Kelly Pertzsch M.A. '11, Katie Fraser M.S. '12, and Kim Fraser, was awarded $10,000 by the judges.
Also competing were Forge Portland, KoKonect, and House of Tayo.
Kicking off the daylong final, Dean Tuajuanda Jordan said, "Today is a milestone, not only for those competing, but for all three schools of Lewis & Clark." As Jordan's comment indicated, students and alumni from all three schools were on the five finalist teams.
Judging the presentations was a panel of accomplished entrepreneurs and venture capital professionals—Tony Abena BS '86, managing director and chief ventures officer at Deloitte Investments; Jerry Carleton JD '07, founder and principal of the Immix Law Group; Kevin Fechtmeyer, managing partner of Cave Creek Capital and parent of a current student; Shannon Heim, sell-side equity research associate for Pacific Crest Securities; Robert Julier BS '66, principal with the Planned Innovation Institute; and Rob Wiltbank, professor of strategy and entrepreneurship at the Atkinson School of Management.
Heim praised the teams for the quality of their ideas and preparation for the competition final. "It was inspiring to listen to each of the teams and see these impressive, entrepreneurially minded young people in action," she said. "It's exciting to see this kind of program being developed at Lewis and Clark."
Closing the event before a crowd of alumni, trustees, students, faculty, and staff, Michael Kaplan, managing director of the new Entrepreneurship Center, announced that the competition will be held again in 2014.
Venture Competition History Entrepreneurship Video


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For 25 years, Emerson Umbrella Center for the Arts has been a network and a home base for creativity of all media, from paint to poetry to performance.
For 25 years, Emerson Umbrella Center for the Arts has been a network and a home base for creativity of all media, from paint to poetry to performance.
Now, center – which celebrated its milestone anniversary with a gala bash last spring – is looking to the future, and hopes to surpass more boundaries with a new performance series, "Emerson Umbrella Presents," with an eye on future projects including a capital drive to improve the facility – formerly a high school built in the 1920s.
"We are seeking to be the region's arts center. We went to be the premier center for the entire area that surrounds Concord, and we think we have the capacity to do that," said Stephen Sorkin, Emerson's director of development, who brings 25 years of experience in theater and performing arts to Emerson.
Collectively, Emerson provides classes in various arts to 1,200 students each year, and hosts 52 resident artists, Sorkin said.
Among other amenities, Emerson boasts a theater with a seating capacity of 430, which in addition to hosting in-house shows is also used by other arts organizations for events.Part of the community
But more than being what Sorkin calls "a haven for the arts," he said, "We need to move forward in offering the community another element … one of the spokes of the umbrella."
And, for those living in the suburbs outside Boston, he said, "You don't have to drive in to Boston to see a first-rate performance."
The inaugural season of "Emerson Umbrella Presents" will include four shows, starting this weekend with Giattino and Schwartz, a New York City-based dance duo who will perform and offer a master dance class. The team -- Melissa Giattino and Richard Schwartz – offer tap dancing and vocal harmonies, with a repertoire that draws from classic swing favorites and contemporary jazz hits.
One goal is to produce a performance series every year, and perhaps expand the offerings beyond the realm of theater, Sorkin said. "We want to build on it … we may do a concert, or something that is more orchestral. We may do something that relates more to modern dance, or we may do a cinema series."
The series is being supported through partnerships with several businesses and organizations, including Community Newspaper Company.
Citing the high costs of any theater production, Sorkin said. "It's not likely to break even at this point," but said even so, the rewards are often in how a series is received in the long run. For example, he hopes the series will prove a boon when seeking funds for improvements to the physical site and expanding center offerings.
To measure how the series' success, Sorkin said Emerson also plans a survey. "We want to find out if the people are pleased," Sorkin said.
If you go
Emerson Umbrella Center for the Arts' "Emerson Umbrella Presents" series lineup is as follows:
- "Giattino and Schwartz," Saturday, Sept. 27, 8 p.m. with a master tap class available Friday, Sept. 26.
- "The Producers," with performances Friday and Saturday, Dec. 5 and 6, and Thursday, Friday, and Saturday, Dec. 11-13 at 8 p.m. with matinee performance Saturday, Dec. 12, 3 p.m.
- "Who's Afraid of Virginia Woolf?," Friday, Saturday and Sunday, March 13-15, and Saturday and Sunday, March 20-22, with Friday and Saturday performances at 8 p.m. and Sunday matinees at 3 p.m. Directed by Robert Knapp. Auditions in January, more details to be announced.
- "Songs of Hunger and Satisfaction: A New Cabaret, created and performed by Belle Linda Halpern, Saturday, May 16 at 8 p.m. With European cabaret songs, marking Halpern's first performance in Concord.
Tickets $20, with discounts available for groups, couples, or purchase of tickets for multiple shows. Seniors and students $15; pre-show dinner packages available through several partnering eateries.
Emerson Umbrella Center for the Arts is at 40 Stow St., Concord. For more information, call 978-371-0820 or visit www.emersonumbrella.org.
Margaret Smith is Arts and Calendar Editor for Community Newspaper Company's Northwest unit. E-mail her at firstname.lastname@example.com.


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An icon never goes out of style; it only gets better with age, just like the Nike Air Force 1 shoe. The AF1 has been a fan favourite among sneakerheads since...
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Register your .radio domain!
Starting tomorrow, if you belong to the radio sector, you can register a new .radio domain, easily recognisable and dedicated to the radio world!
- Dominiando
Identify your radio activity online, take the opportunity to be among the first to register your .radio domain!
Starting tomorrow, November 15, anyone will be able to register a .radio domain, provided they belong to the radio sector!
The registration of a .radio domain is, in fact, reserved exclusively for radio stations, web radios, amateur radios, radio service providers, companies and people who have a specific interest in the sector.
Holders of a .am and/or .fm domain, very often used to identify online radios, will now be able to benefit from a new domain that best suits their radio activity, and add to their domain portfolio!
What are you waiting for? Register your name immediately under the radio extension to promote your radio and affirm your online presence!
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Configure the zoom level on the camera for taking a photo.
#include <camera/camera_api.h>
camera_error_t camera_set_zoom(camera_handle_t handle, unsigned int level, bool smooth)
- handle
The handle returned by a call to the camera_open() function.
- level
An unsigned int value which falls within the minimum or maximum range returned by camera_get_zoom_limits() function. A value of 0 indicates not to use zoom. Values larger than zero indicate increasing magnification.
- smooth
A of true specifies to zoom to specified level value, while a value of false, specifies to jump to the specified zoom level.
This function can be called if the CAMERA_FEATURE_VIDEOZOOM or CAMERA_FEATURE_PHOTOZOOM feature are available. You can determine whether the feature is available by calling the camera_can_feature() function. In addition, the photo or video viewfinder must be started using either the camera_start_photo_viewfinder() or camera_start_video_viewfinder() functions, respectively.
The value that you specify as the level argument sets the viewfinder zoom-level. The zoom level is a value supported by the camera hardware and can represent an optical or digital zoom depending on which the hardware supports.
You can specify whether to use smooth zooming using the smooth argument. You can use the camera_get_zoom_limits() function to determine the supported zoom levels and whether the camera supports smooth zooming.
CAMERA_OK when the function successfully sets the zoom level, otherwise another camera_error_t value that provides the reason that the call failed.


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Pittsburgh's womens football team starts new chapter
Season opener Saturday night at Highmark Stadium
The Pittsburgh Passion women's football team opens its 11th Season this Saturday at their new home field, Highmark Stadium in Station Square. Their new stadium will host a clash between the Passion and their biggest rival, the Washington D.C. Divas. Kickoff set for at 7:00pm.
The Passion is co-owned by former Steelers star Franco Harris and coach Teresa Conn. They captured the national championship in 2007. More recently, the Passion and Heinz Field hosted the Womens Football Alliance National Championship game in August 2012.
In addition to kicking-off play at their new home field, the Passion plan to honor all service members on April 6th. All military, police, firefighters, and veterans in attendance will be recognized at half-time.
After opening the season at home against the D.C. Divas on April 6th, the Passion will travel to Ohio to play the Toledo Reign on Saturday April 13th. The Passion will travel to New York on Saturday April 20th for their next road game against the NY Sharks, before returning home for April 27th to play the Columbus Comets. The Pittsburgh Passion are a member of the Women's Football Alliance, a full-contact American football league comprised of 62 teams across the United States.


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"30 Rock," the hit NBC television show featuring Tina Fey, aired tonight with Boba Fett making an appearance. The character Lutz dons the costume.
For better or worse, it's a joke about geeks. The story is that the characters are having a Halloween party and a neighbor comes by to ask them to shut the blinds because they're bumming everyone out.
You can legally watch "30 Rock" for free, including this episode (Season 4 Episode 5), for a brief period of time at hulu.com/show/44.
(Thanks to long-time BFFC contributor, Eric Cromwell, for the screenshots.)


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Symphony Assistant Principal Violist Emily Freudigman is teaching this summer at the Youth Orchestras of San Antonio (YOSA) Summer String Camp. Like many members of the Symphony, Emily plays a very active role in the music education scene in San Antonio. She sent me these photos and this report about the camp.
"As promised, here are some photos from YOSA's 2010 Summer String Camp. You'll see a few of me working on bowing technique with some of the junior campers and also one of the campers getting ready to perform at the Silver Stars game last Friday at the ATT Center. They played a medley of Queen favorites that I've heard the crowd really loved.
This is my third summer teaching at YOSA camp and it is an exhausting and exhilarating two weeks. I teach five viola sectionals every day – one for each of five different orchestras at the camp, arranged by skill level from beginners to high school students. It's daunting to face a roomful of young violists, keeping order while also keeping things fun so they have a good time while they're learning! All the kids also do chamber music, so I coach an octet (four violins, two violas and two celli) – by their concert Thursday, they will have learned an arrangement of tunes from Carmen from scratch to performance standard in just 10 days!
The faculty is composed of area orchestra directors, performers, and YOSA staff. It's a great team and works together to create the best learning environment for the campers. We all have different strengths. I have learned so much from the orchestra directors in particular about effective teaching methods that I try to incorporate into my own teaching year round. There is also a dedicated crew of interns – mostly college students preparing for careers in music and music education.
YOSA's 2010 Summer String Camp's Grand Finale concert is this Saturday at 11AM in the auditorium at St. Mary's Hall (9401 Starcrest). It's free and will conclude, as always, with all six orchestras playing one piece all together – it's quite a spectacle!"
Sundays at 2 p.m. on KPAC 88.3 FM and KTXI 90.1 FM
July 25: Dvo?ák, Shostakovich, Brahms; Rossen Milanov, conductor.
August 1: Assad, Debussy, Prokofiev, Beethoven; Alondra de la Parra, conductor.
August 8: Strauss, Beethoven, Dvo?ák; Jean-Marie Zeitouni, conductor.
August 15: Tchaikovsky, Sibelius, Mendelssohn; Christoper Seaman, conductor.
August 22: Haydn, Rodrigo, Nielsen; David Angus, conductor.
August 29: Bartók, Webern, Strauss; Julian Kuerti, conductor.
September 5: Williams, Holst, Saint-Saëns; Andrew Grams, conductor.
September 12: Turina, Piazzolla, Rachmaninoff; Josep Caballe-Domenech, conductor.
September 19: Schubert, Golijov, Stravinsky, Canteloube; Cliff Colnot, conductor.
September 26: Beethoven, Bruch, Elgar; Christopher Seaman, conductor.
Jack Fishman
Email: firstname.lastname@example.com
For more blogs by Jack Fishman visit: www.sasymphony.org/blog
The SLL era begins October 2!


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Your analysis of your local problem should give you a better understanding of the factors contributing to it. Once you have analyzed your local problem and established a baseline for measuring effectiveness, you should consider possible responses to address the problem.
The following response strategies provide a foundation of ideas for addressing your particular problem. These strategies are drawn from a variety of research studies and police reports. Several of these strategies may apply to your community's problem. It is critical that you tailor responses to local circumstances, and that you can justify each response based on reliable analysis. In most cases, an effective strategy will involve implementing several different responses. Law enforcement responses alone are seldom effective in reducing or solving the problem. Do not limit yourself to considering what police can do; carefully consider whether others in your community share responsibility for the problem and can help police better respond to it.
Most researchers and practitioners agree that focusing solely on arresting those engaging in public sexual activity is unlikely to reduce the overall scope of the problem. In your response strategy, you should acknowledge that it will be difficult to affect people's motivations for engaging in the activity. A balanced approach combining enforcement strategies and those targeting environments that support the behavior is most likely to decrease the prevalence of the activity and the public's concern about it.
Used alone, enforcement efforts are likely to lead to displacement. Although not the most desirable outcome, there is evidence that when displacement does occur, the magnitude of the problem decreases with the move to a new location. New locations are often less desirable for several reasons, including distance and suitability. Further, changes in the times of day or days of week on which the problems occur mean that response affected the problem in some way. When displacement occurs, police can often better manage the problem.
In the past, police have been criticized for using undercover or decoy operations. These operations, particularly when conducted improperly, leave the police vulnerable to entrapment claims. In addition, an exclusive focus on environments in which same-sex interactions occur can result in charges of bias and discrimination. Therefore, you must address the full range of public sexual activity and target particular locations based on objective, justifiable assessments of threats to public safety.
In 2000, the Lambda Legal Defense and Education Fund filed suit against the Los Angeles Police Department for its allegedly discriminatory law enforcement tactics targeting gay men.
If same-sex public interactions are part of your local problem, you should develop partnerships with local leaders of the gay and lesbian community and involve them in problem-solving. Not only can their endorsement go a long way toward addressing charges of bias or discrimination, but local leaders can also publicize the problem among the larger gay population and rally support for the responses.† Similarly, efforts to control public sexual activity may affect local businesses, whose perspectives you should consider when planning your responses.‡
† The Denver Police Department, Equality Colorado (a statewide gay-rights organization), and Cheesman Park West Neighborhood Association formed a coalition to address problems caused by sexual activity in a public park. The partnership helped to "build bridges over the gay community's persistent fear and mistrust of law enforcement" (Luzadder 2000).
‡ For example, Mardi Gras celebrations contribute an estimated $1 billion to the New Orleans economy each year (Filosa 2002).
Finally, some of the responses below suggest some level of tolerance of the behavior—an approach that has had some success in Europe. However, community and political attitudes will make tolerance-based responses either more or less feasible. Therefore, before you design any responses, you must assess how much public sexual activity your community will tolerate. You can initiate candid and specific discussions about the types of activity to target by using videotapes and photographs to document the scope of the problem.§
§ The Santa Ana (California) Police Department used videotape and photographs to document the types of sexual activity occurring in a public park. The visual aids revealed the extent of the problem and were used to advocate special court-imposed probation conditions. They were also used to counter criticism of police efforts, as they showed activity clearly unsuitable for a public park (Santa Ana Police Department 2001).
Enforcement-based responses may be particularly effective when applied to activity such as flashing during annual events, because this conduct is often considered acceptable unless police demonstrate a commitment to controlling it. In particular, regarding annual events, there is reason to believe that the word will quickly spread that the police no longer tolerate such behavior.
Signs warning against exposing oneself in public serve to increase awareness of acceptable practice.
† The San Diego Police Department posted the following notice in conspicuous locations throughout a public park: "Lewd Conduct Laws Strictly Enforced. Lewd Acts in Public Are a Violation of 647(a) PC. All Areas Within This Park Are Public Places. Violators Will Be Arrested" (Hall and Brady 1994). Similarly, in an effort to reduce flashing during Mardi Gras, New Orleans police posted approximately 1,000 posters throughout the French Quarter warning parade watchers that flashing is a crime that carries a $1,000 fine and jail time (Times-Picayune 2000).2. Issuing warnings. Rather than making an arrest, police can issue warnings to suspected participants in public sexual activity. For example, police can warn women observed flashing their breasts that continuing to do so will result in arrest. Similarly, police can stop and warn men observed cruising known locations for public trysting.‡ Because many people do not want their behavior to be exposed to family and friends, specific deterrence may be effective. If the behavior occurs in a crowd that largely supports the participants (e.g., during Mardi Gras), police should be aware of the potential for conflict and use a non-confrontational approach.42
‡ Establishing the legal grounds to stop a vehicle can be problematic because it is difficult to distinguish innocent from suspicious behavior. Departments wishing to use this response should seek legal advice.In addition, police can contact the registered owners of cars parked in public areas with high sexual activity levels. Letters notifying owners that police observed their car in such an area can also warn of the risk of violence and the health consequences of participating in anonymous, unprotected sexual activity.43 However, because the targeted behaviors are not serious public-safety risks, concerns about this response's potential to deter legitimate patrons from using the areas and about unnecessary invasions of privacy may outweigh the response's potential effectiveness.
† The Santa Ana Police Department stationed unmanned, marked police cars throughout a park to give the illusion of constant police presence (Santa Ana Police Department 2001).4. Establishing highly visible patrols. Although some participants in public sexual activity seek an audience, others want privacy. Uniformed police officers and park rangers in patrol cars, on foot, or on bicycle can deny potential participants privacy for such activity. Opening a police substation (e.g., mobile office) can also effectively increase the level of police activity in a particularly problematic area. However, this is a labor-intensive and thus costly response.
† The North Wales Police Department addressed complaints about indecent exposure by nude sunbathers by clearly designating the boundaries of a nude-sunbathing area, and posting signs reminding sunbathers to stay within the boundaries and to dress fully before returning to public areas (North Wales Police Department 2002).9. Improving lighting. Improved lighting in problem areas reduces their attractiveness as trysting locations because the lighting reduces perceived privacy levels. Tamper-resistant, motion-sensing lighting may be useful at restroom entrances and in alleys.
Clearly posted signs indicating rules such as time restrictions on the use of public areas can help reduce unwanted activity. Credit: David Corbett
† The San Diego Sheriff's Department's partnership with the North County Gay and Lesbian Association led to stories in gay publications that educated readers about the dangers of cruising and discouraged them from using specific locations being targeted by police (Won 1996).Paradoxically, media coverage may also increase activity levels at the identified locations. For some, the increased attention may heighten their excitement about engaging in illicit sexual behavior.47 For others, the publicity may confirm a location's reputation as a good place to find partners.
† The San Diego Police Department made a written request to a variety of websites and guidebooks that listed a targeted property as a popular cruising location. Some organizations complied with their request; others did not (Hall and Brady 1994).
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