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Why You Should Be Paying Attention To Kevin Smith
from the where-the-puck-is-going-to-be deptIt was almost exactly two years ago this week that I did my presentation at Midem concerning Trent Reznor and his many fascinating experiments in reinventing the music business (for himself), and summarized it down to the simple formula of:
The idea, of course, was not that he had figured out "the one true model," but that he was doing a ton of interesting experiments, some of which worked better than others, but all of which seemed to focus around this basic concept of really making sure to build up a strong connection with the fans, and then figuring out ways to let those fans support him as directly as possible. While some have complained that Reznor could afford to do this given his previous success in the "old" industry, we've seen tons of other musicians, big, medium and small, figure out how to use the same basic concepts for their own careers. And, it's not about copying Reznor or just trying to do some sort of gimmick, but really figuring out the best ways to connect with their fans, and then offering up opportunities to buy.
What's been amusing, however, is how often I now hear that "maybe this works for the music industry, but it could never work for the *blank* industry" -- and you can fill in your blank. A few months back I was in Hollywood on a panel discussion at the Filmmaker's Forum, talking a lot about how to apply these same basic concepts to the movie industry, and I was told "but movies are different." I've heard that about software, books, video games, financial services, you name it. And, yet, if you look deep enough, you begin to see folks in each of these industries figuring all of this out on their own.
For those interested in where the movie industry is going, I have to say that the person to watch is Kevin Smith. I've written about some of what he's done before, but he's continued to do some interesting (and, at times, controversial) things. I have no idea if he'll succeed with them, but if you want to understand how to succeed, you should be paying attention to what he's doing either way. Like Reznor, he's breaking conventional wisdom, and trusting his instincts on -- as he says -- skating to where the puck is heading, rather than where it's been.
This weekend Smith garnered a ton of attention for debuting his latest film, Red State -- a horror-thriller-type flick -- at Sundance. He's drummed up extra attention by announcing for weeks that after the film debuted Sunday night, he was going to hold a live auction to find a distributor, rather than go through any backroom negotiations. There were some rumors that he'd already lined up a deal, which he denied, and then when the moment of truth came, after mocking the way things have been done in the past in Hollywood, Smith cut short the "bidding" by buying the film himself for $20, and announcing that he was going to take it on tour around the country starting in March, before releasing it in wider release in October.
While this has some of the Hollywood insiders grumbling (and, admittedly, it was a bit of a cheap shot to suggest he was going to do one thing and then do something else), if you'd been paying attention this wasn't a huge surprise. For the last few months, Smith has been hosting a fantastic podcast/film school all about the movie, called Red State of the Union, in which he brought out a variety of different people involved in the film, obviously including a bunch of the actors, but also the producer, the casting director, the director of photography and the assistant director. Smith would interview them (and, he may be one of the best interviewers around, ever -- something he doesn't get much credit for, which is a shame) and then take some questions from the audience. On top of that, he's been running another podcast called Smoviemakers, in which he similarly interviews other movie makers (so far, only Richard Kelly and Edgar Wright -- but both are fascinating).
If you've been listening to them (and potentially some of Smith's other podcasts), you'll have heard him (repeatedly) talk about the ridiculous way in which movies are marketed and sold today. He's talked about how silly it is to focus so much on a movie's "opening" weekend, which is how almost all movies are judged. He's noted that you can "buy" an opening by spending more on advertising than you did on the film, but that does little to determine whether or not the movie really has longevity or can connect with an audience. In fact, hearing all that, I was a bit surprised that he was planning to go with a traditional distribution method in the first place -- and I guess I should have trusted my instincts.
As for what he's doing now with the movie, well, that's really not as far-fetched as it might sound. As we've noted in previous posts about Smith, he's had tremendous success touring the country (in his custom tour bus) doing his famous Q&As (which are not to be missed) along with doing live versions of the various podcasts he does. He's basically doing the same thing with the movie. It's really a movie plus a Q&A with him and (apparently) the lead of the film, Michael Parks (at least according to Slashfilm). Smith already knows that formula works (though, now he's adding a movie to it).
And all of this, of course, is predicated on the fact that he's connected with his fans by the tweet-load.
Of course, it doesn't stop there either. If you want to keep watching where the puck is going, look beyond Red State. A year ago, we'd mentioned rumors that Smith was considering crowdfunding Red State -- a move he eventually decided not to do (they got two outside investors to pony up the $4 million). However, he's since admitted that he really regrets not doing that, and some of his talk at Sundance suggests that after his next movie, Hit Somebody, he's going to focus on creating a platform for others to make movies, talking about how anyone can make movies, if they stop playing the old Hollywood game (something we've been discussing as well).
Again, who knows if he'll end up being successful with this particular strategy. He's taking a calculated risk that probably isn't as big as it might look from the outside. What's much more fascinating is that, like Reznor in the music industry, Smith is also showing the rest of the world where the industry is heading. If you're not paying attention (of if you're dismissing it for whatever reason), you might miss something important.
While both Reznor and Smith have taken very different approaches to going about all of this -- and both have very different styles and personalities -- I think the similarities between what each has done is really incredibly strong. They've both built up huge, and incredibly passionate and loyal fanbases, and worked hard to keep them happy for many, many years. Each has a great story of how they first broke through. Each has had interesting ups and downs and career twists in the intervening years -- and each has now figured out ways to rethink the industries that they're most well-known for being a part of. In fact, I think it would be fantastic if there were some way to get the two of them together to talk about the future of entertainment, because I can't think of a conversation that would likely be more interesting than that. I'd actually love to facilitate just such a discussion, but I don't think either Reznor or Smith need me to do so -- so let's just hope it happens one way or the other.
Filed Under: business models, kevin smith, movies, red state, trent reznor


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The Chang re-effect: New place, new movie, and taking NYC by storm
The Year of the Dragon is turning out to be a special one for chef Peter Chang and his partners Gen Lee and his wife, Mary, who opened Peter Chang's China Grill in the Barracks Road Shopping Center last year. For our March 2010 cover story on the elusive chef, we remember stumbling across Lee at the Li'l Dino Subs shop he owns in Albemarle Square. At that time, Lee served as an unofficial translator for Chang, who was cooking at Taste of China next door, the setting for a profile in the New Yorker that set the local food scene abuzz.
Lee, an experienced executive chef himself, would partner with Chang to create a permanent home for Chang in Charlottesville, something many doubted would really happen.
Well, it did happen, and just last month Lee found himself a long way from his Li'l Dino Subs shop: at the famed James Beard House in Manhattan, where Chang and his wife Hong Ying Zhang (an exceptional chef in her own right) found themselves cooking for the elite of the New York food scene, including a well-known actor/director and producers for Fox Searchlight Pictures who plan to make a film based on Chang's cooking-life called Where's Peter Chang? The event was sold out two weeks in advance.
Just a few days earlier, Lee had hosted a Charlottesville version of the event (also captured by Allen), which attracted some local celebs like author Jonathan "Jerry West" Coleman and C-ville Weekly editor Giles Morris.
"It was crazy," Lee laughs, describing the New York event. "And Peter cooked the real Chinese food. They are so used to French cooking there, so we stirred them upside down. But they loved it."
Lee says he also got to meet actor/director Stanley Tucci, known for starring in and directing food tales like Julie & Julia (he plays Julia Child's husband) and Big Night, as well as numerous TV appearances.
What's more, the Hook's sometime videographer, Anwar Allen, captured the event.
"Tucci and the producers were on the top floor," says Allen, "where they seat all the high-profile guests, I suppose."
One interesting thing about the event, says Allen, was that everyone was allowed to wander through the kitchen as Chang and his crew cooked.
Allen says that Jefferson Vineyard's Andy Reagan, who was there to pair Chang's food with the local vineyard's wines, was allowed up top first to introduce his wines, followed by Chang and his crew.
"Everything was great," says Reagan. "The food was outstanding, and the wines were all very well received. "
As if that weren't enough to start the Year of the Dragon, Lee and Chang opened another restaurant in Short Pump, Peter Chang China Cafe, on February 8, ensuring that the famous chef will be based in our area for the foreseeable future. We hope.
The Hook's occasional videographer, Anwar Allen of Humbledown Production, captured Chang and company at a star-studded affair at the James Beard House in NYC on January 30.Read more on: peter chang
2 comments
The Sarah Palin of cooking. I've tasted his food numerous times, and although it's perfectly decent cooking, the media infatuation is bizarre to say the least.
I was fortunate enough to be invited to the Chinese New Year celebration and wrote about it. He was incredibly gracious and the food extraordinary. I wish him well... http://thedinerofcville.com/2012/01/23/chinese-new-year-at-peter-changs-...

subset: commoncrawl


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|Scuola di San Rocco
|Antonio Damasio
According to Wired, Damasio is one of the most important neuroscientists of his generation; his latest book is called Self Comes to Mind. Damasio spoke about the importance of emotion with respect to consciousness, and said we cannot be conscious without feelings -- something I always thought was obvious, but apparently not -- Damasio said feelings are often ignored in accounts of consciousness. I was surprised to hear this information because my personal method of consciousness relies heavily on how I feel about something, even if I am being told something entirely different; my memories are stronger if there is emotion attached to the memory. Damasio said that the most important qualities for a human being are beauty and compassion for others, something I, too, strongly believe, and something that seems to becoming more of a rarity on this planet. From Wired:
...reflection on the experience of conscious minds also convinced me that feelings need to be given an even more important role in the making of subjectivity. We do not merely perceive objects and hold thoughts in our minds: all our perceptions and thought processes are felt. All have a distinctive component that announces an unequivocal link between images and the existence of life in our organism.
To read the entire Wired interview by Jonah Lehrer, please click HERE.
The party over at Ca' Foscari after the inauguration was fantastic, with an international feast. Yummy Venetian, North African, Chinese and South American food was on the menu, all prepared by La Dogaressa, accompanied by an unending supply of excellent prosecco from the Consorzio Tutela del Conegliano Valdobbiadene. Moleskine was there with its enormous Infinite Writing book, a project by Bili Bidjocka, who is collecting the marks of handwriting for a time capsule for the future. I love Moleskine, and use their agendas faithfully to record all my trials and tribulations -- mine is red. On the page where you record who to return to in case of loss, I wrote "As a reward: $TICKET TO HEAVEN." The Moleskine representatives at the party were uber-cool. I raved about their product, and told them I would not exist with my Moleskine -- and was rewarded with a nifty Moleskine WikiAfrica notebook! From Moleskine:
|Ecriture Infine/Infinite Writing
Ecriture Infine/Infinite Writing is an art project that celebrates a 3500-year-old invention: handwriting. Created by Cameroonian artist Bili Bidjocka, it consists of a series of eight volumes that travel the world collecting the marks of handwriting as we know it. Once completed, the volumes are wrapped in a linen cloth, sealed and hidden in a secret place, like a time capsule. Will the people who discover them in thousands of years be able to understand what they mean?
We were asked to express our thoughts and feelings about handwriting. I wrote: "Handwriting is the mark of the soul. Cat Bauer - April 18, 2012." In fact, everyone can participate in the project through the miracle of cyberspace. Go to the Moleskine page, and follow the instructions to upload your handwriting.
|Ghada Abdel Aal
Wanna be a bride (Egyptian Arabic: عايزة أتجوز [ˈʕæjzæ (ʔæ)tˈɡæwːez]) alternately translated as Wanna-B-A-Bride or literally: I Want to Get Married is the title of a popular Egyptian book based on a blog of the same name about the several (failed) marriage proposals the author Ghada Abd El-Aal has gone through.The book was published by the Egyptian printing house Shorouk in 2008. It has been translated into Italian by Barbara Teresi and released under the title Che il velo sia da sposa! by the Italian printing house Epoché Edizioni. It has also been translated into English by Nora Eltahawy, published by the University of Texas Press on 23 September 2010.
Aal said that before the Internet, living in Eqypt was like living on separate islands. There was a law that it was forbidden to talk about politics, and any group of three people or more could be arrested. After going online, she discovered she wasn't the only one interested in books, culture and politics. She said that in Egypt, the way people got married was that you would meet your future husband three or four times, and then be asked to make a decision. Nothing was forced upon you; you could always say no; but you spent more time in deciding what refrigerator to buy than you did on your future husband. She thought something was wrong with that, and started blogging about it with humor, and found an audience who felt the same way she did, both male and female. When asked about the recent revolution in Egypt, she said that "Our country deserves a better future -- better than the one we were living in." She said that it took ten years to have a revolution after living for 30 years under a corrupt regime and that more time was needed to learn what the results are. "You can't judge a revolution after 24 months."
|Malika Mokkeddem
Malika Mokkeddem was born on October 5, 1949 in Kenadsa, a small mining town on the limit of the western desert of Algeria. She is the daughter of an illiterate nomad family who became sedentary. She grew up listening to the stories told by her grandmother, Zohra, and was the only girl in her family and town to finish secondary studies. She enrolled to study medicine in Oran and finished her studies in Paris. She specialized in Nephrology and later established in Montpellier in 1979. She practiced till 1985 when she decided to dedicate her time to literature.
Mokkeddem said that she wanted to get away from her family, and to be exiled from one's family is the worse thing. "Not everyone is fortunate enough to be an orphan." She said that many people drown in the Mediterranean sea trying to get away from her country, and that the sea was like a "liquid continent."
|Alawiya Sobh
Alawiya Sobh (Arabic: علوية صبح) (born 1955) is a Lebanese writer and novelist.[1] She was born in Beirut and studied Arabic and English literature at the Lebanese University. Upon graduation in 1978, she pursued a career in teaching. She also started publishing articles and short stories, at first in An-Nida newspaper and then in An-Nahar. After a spell as cultural editor, she became editor-in-chief of Al-Hasnaa, a popular Arabic women's magazine, in 1986. In the 1990s, she launched her own women's magazine and runs it to this day. Sobh has written a number of novels. Her debut novel Maryam al Hayaka (2002) was critically acclaimed. Dunya was published in 2006. A recent novel It's Called Love was longlisted for the Arabic Booker Prize in 2010.
|Howard Jacobson
Although Jacobson has described himself as "a Jewish Jane Austen" (in response to being described as "the English Phillip Roth"), he also states, "I'm not by any means conventionally Jewish. I don't go to shul. What I feel is that I have a Jewish mind, I have a Jewish intelligence. I feel linked to previous Jewish minds of the past. I don't know what kind of trouble this gets somebody into, a disputatious mind. What a Jew is has been made by the experience of 5,000 years, that's what shapes the Jewish sense of humour, that's what shaped Jewish pugnacity or tenaciousness." He maintains that "comedy is a very important part of what I do."
|Marciana Library - Venice
|New York Public Library
In short, the CLP needs to be stopped. The stakes are not just local, and I hope readers of this column will do their part in spreading the word, whether they live in the city or on the other side of the planet.
The CLP calls for transferring 3 million volumes from the New York Public Library building on 42nd Street (the one with the lions) to storage facilities in New Jersey so that the space they now occupy can be redesigned to accommodate computers for public use. Not that books will disappear from the 42nd Street branch altogether. It will become a lending library, rather than a research collection that is available to the public but restricted to use within the building.
Please click HERE to read the entire STOP CULTURAL VANDALISM article. And, again I ask: Why isn't there a single copy of my second novel, HARLEY'S NINTH in the entire New York Public Library system, a library where I have spoken, a library that has always been supportive, a library that provided me with a Teen Advisory Group? I was told by my contacts inside the NYPL that it had been ordered, and it's not there. In addition, there were more than 40 copies of my first novel, HARLEY, LIKE A PERSON in the NYPL, both the Winslow Press and the Knopf editions. Now there is only one copy out in Fort Washington. Does it mean that when the Donnell branch was eliminated, and the children, young adult and foreign language collections were dissolved, everything just disappeared? What's going on over there?
|Palazzo Ducale
Malika Mokeddem - Algeria
Alawiya Sobh - Lebanon
Howard Jacobson - Great Britain
Xu Xing - China
Andrea Cavazzuti - Italy
Alicia Gimenez-Bartlett - Spain
Andrea Molesini - Venice
Ariane Ascaride - France
Robert Guediguian - France
Maaza Mengiste - Ethiopia
Hisham Matar - Libya
Alain Mabanckou - Republic of Congo
Wim Emmerik - Netherlands
Giselle Meyer - Netherlands
Steve Sem-Sandberg - Sweden
Per Olov Enquist - Sweden
Santino Alexian Spinelli - Italy
Juan Villoro - Mexico
Vladimir Sorokin - Russia
Cees Nooteboom - Netherlands
Roberto Calasso - Italy
William Dalrymple - Scotland
Here's the link to last year's Venetian Cat - The Venice Blog account:
Incroci di Civiltà 2011 - Crossroads of Civilization 2011 - Writing: The Spooky Art
Ciao from Venice,
Venetian Cat - The Venice Blog


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Oscar for San Diego story 'Inocente'
Documentary short about homeless teen takes home a statuette
When Inocente Izucar stepped onto the Oscar stage Sunday night, she carried with her countless dreams.
"I was there for all those voices that haven't been heard," she recalled Monday.
"I stood up there representing Latinos, people who have been homeless, immigrants, struggling artists. Being able to stand up for everybody else has been amazing for me," said Izucar, whose life as an unauthorized immigrant and homeless child is the subject of the short documentary "Inocente."
The night was surreal for her, from walking the red carpet at the Dolby Theatre in Hollywood to making her way up to the stage with filmmakers Sean and Andrea Fine when the documentary won an Academy Award. "Inocente" was the first Oscar winner to be funded by a social-media fundraising campaign — this one on
Izucar was 15 years old when the filming began. The 40-minute movie chronicled her turbulent life and coming of age. She was homeless for nine years after her father was arrested for domestic violence and deported. She moved from school to school. She once talked her desperate mother out of jumping off the San Diego-Coronado Bridge and taking her children along with her.
Through it all, Izucar relied on her art to sustain her — and to eventually save her.
She created big, brilliant and vivid images, painted in broad brush strokes on canvas, sometimes with her hands.
"My life depends on me being an artist," she said in the film.
Izucar came to the attention of the Fines through Matt D'Arrigo, the founder of ARTS: A Reason to Survive, a nonprofit program in National City that provides education and therapeutic activities to children facing crises such as homelessness and domestic violence. She had been attending the program since she was about 12. At first she came weekly as part of visits with her school, then gradually she took public transit to the ARTS center every day.
The Fines contacted D'Arrigo because they were driven by the statistic that one in 45 children is homeless. They hoped to find a child through which to tell the story of homelessness.
D'Arrigo immediately thought of Izucar.
He remembered that when she walked into the center for the first time, she had her face painted and wore a rainbow tutu. She was exactly the kind of person D'Arrigo had in mind when he established the program.
D'Arrigo grew emotional Monday as he discussed the Oscar win and Izucar.
"It shows the power of art and the power of mentorship," he said. "Art is where you can let your secrets out. All of the kids carry their own struggles, and there is this unsaid feeling of acceptance and peer support."
Izucar said she found a home of sorts at the center, the kind she had never experienced, a haven where she could create and be herself.
"My inspiration comes from trying to change my past in a positive way," said Izucar, who is now 19 and living in San Diego. "I can never really change it, but I can change the way I see it."
The Oscar win catapults the self-described shy artist into the international spotlight. Less than a day later, she had received numerous requests for her work, college scholarship offers and invitations for various projects.
First on her plate, she said, is to continue her advocacy by attending more screenings of the documentary speaking about homelessness, arts and immigration. She also intends to do another art show in New York — she had one last year — and hopes to choose a college in the coming year.
She hopes to inspire children by letting them know they, too, can find a way to achieve their dreams.
"My main message is to never give up — seeing all the things I went through and it eventually turned out OK. That is the main thing: It is going to be OK," she said.
Since filming of the documentary wrapped up, Izucar's life has expanded in new ways. Her family received legal residency status, said D'Arrigo, who pushed for the legalization process to be completed before the film's release to protect the household. Izucar moved into her own apartment last year, which she now shares with her two adopted bunnies, and launched a website to sell her art.
She continues to work with D'Arrigo, who has helped her manage the requests she is receiving and preserve her legal rights to her artwork.
ARTS hosts about 200 children a week and works with about 4,000 annually.
"For kids who are artistic and creative, art is their power," he said. "Through art, they are finding their happiness and joy — and they probably can't find it in other areas of their lives."
Watch it:
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Movie Details
Find Movie Theaters & Showtimesfor
Videos & Photos
Movie Info & Cast
- Robert Downey Jr.
- Antonio Banderas
- Michael Sheen
- Jim Broadbent
- Jessie Buckley
- Harry Collett
- Emma Thompson
- Rami Malek
- John Cena
- Kumail Nanjiani
Did You Know?
- This is Robert Downey Jr.'s first non-Iron Man role since The Judge (2014).
- When going to see the Queen, the animals and Rose claim they are going to Buckingham Palace. Yet, they arrive to Blenheim Palace, which is not only not a royal palace, but also not remotely similar in either location or architecture to Buckingham Palace.
- Dr. John Dolittle: We've no choice but to embark on this perilous journey.
Atom User Reviews
I spent $30 on Tickets, $20 on Snacks... Kids were awake through the Trailers, they were more interesting, and fun than the actual movie was. 15 minutes in the movie my kids fell asleep. $50 to sleep. I stayed awake for every terrible moment of the movie; cliche jokes, predictable plot, lame humor, everything about the movie was terrible. The trailer for the movie made Dolittle seem like it was going to be an epic. Nope. The VFX, voice acting, and barely tolerable quickly cut scenes make this movie something that came out in 00'. Don't even watch this on Netflix/Redbox - save your time & money.
Many laughs throughout the movie! A must see!
Whether it's Downey's mannerisms or the dull quipping provided by his menagerie of digital co-stars, Dolittle is a joyless slog trying to pretend it's a hip, magical adventure.
This is a film that just very expensively sits there onscreen with nothing ever seeming even remotely at stake. It has no weight or substance and delivers no impact of any kind.
An unpleasant, incoherent mess that feels like it was stitched together from outtakes and reshoots of something that used to look totally different.


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Intelligence – Responsive Email marketing Template
Intelligence is a responsive email marketing template with two color schemes. The complete template is build modular and is retina ready. PSD files are included. Also as bonus you will get 5 more color schemes. Intelligence has been tested and approved in 30+ different email clients.
Now includes a Template Generator!
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Here's my situation;
I'm the lead web designer for a web site that serves as a communications hub for a non-profit spanning 3 US States (WV, OH, and PA). We are currently planning for a major re-organization where our user base will be increasing from about 400 to around 1000. Also, our admin toolbox has approx. 100 pages each with View / Update / Delete Permissions (plus a few variations which add levels to view and update).
Our current system;
uses a combination of BaseGroups and SubGroups. BaseGroups being high-level roles such as 'Admin', 'Key', 'Appointed', 'User'. And SubGroups granting low-level admin access to specific areas such as 'News', 'Events', etc. We have been plagued with short comings with this system as it's not very fine-grained. This, combined with the much larger user base, has lead us to looking for a hierarchical permissions system where permissions can be inherited down from higher levels.
Valek, on 16 Mar, 2009 - 01:11 PM, said:
Okay, another solution would be taking the settings for all of the permissions and concatenating them, making a comma-separated string of numbers for their settings. That gives you 1000 x 1, but controlling the permissions takes a bit more backend as a result.
That would make it a 1000x1 matrix physical. Logically, it would still be 1000x300. Also, database normalization is very key to us (which CSVs break)


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Working to Help Our Loved Ones Live "A Life Like Yours"
Our vision is for people with developmental and intellectual disabilities to be fully participating members of the community, living "A Life Like Yours."
That means:
People of all abilities deserve to be a part of the community -- not apart from the community.
As a local chapter of The Arc of Virginia, we serve the Tri-Cities area. This includes Petersburg, Hopewell and Colonial Heights, as well as surrounding counties like Dinwiddie, Prince George and Chesterfield.
Visit us on Facebook to learn about current issues and upcoming events.


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Back in November of last year (2009) I began a new Sunday morning routine. Hot Vinyasa Yoga followed by a Starbuck's Orange Mango Vivanno Smoothie with matcha. If you have never taken a hot yoga class, picture this… an enclosed yoga studio filled with 25 plus yogis and the heat cranked up anywhere between 95 to 100 degrees for an hour and fifteen minutes. Only one word appropriately describes the experience – INTENSE! Upon completion, I have had the workout of my life, not to mention I am incredibly hot, dripping with sweat, and invigorated. A few hours later, I love to sit and enjoy a hot cup of tea. Today's choice Green Tea Antioxidant Supplement.
Composition: Green tea, white tea (Bai Mu Dan), eleuthero root, alfalfa leaf, stevia leaf, natural lemon and orange flavors with other natural flavors (contains soy lecithin), rosehips, and roasted chicory.
Dry Visual: It is difficult to tell as the tea is contained in tea bags. From what I can tell, the leaves appear to be fannings. Thanks to Celestial Seasonings for the photo.
Dry Aroma: The tea bag inhibited my ability to develop an impression of the dry aroma. However, after steeping the leaves had a strong citrus aroma with orange and lemon dominating.
Flavor: Consistent with the wet aroma Green Tea Antioxidant Supplement has a definite citrus flavor followed by the distinct floral tastes of roses. As the cup begins to cool, the chicory presents itself in the middle – significantly, yet not overpowering. With the various flavors of citrus, chicory, and floral I was unable to easily discern the green and white tea flavors. Green tea is the predominant tea ingredient; however, Green Tea Antioxidant Supplement is not vegetal.
Green Tea Antioxidant Supplement has a mild astringency that becomes more pronounced throughout the cup. I drank the first cup without sugar – the stevia leaf provided a delicate sweetness. In the second cup I added Sugar-In-The-Raw to see the impact of the sweetener on the slightly tart citrus flavors. Interestingly, I found the chicory came alive with the addition of sweetener. I prefer drinking Green Tea Antioxidant Supplement without a sweetener. As a side note, many say ground roasted chicory can be used as a coffee substitute. I say it tastes like black licorice. You tell me…
Liquor: A pale greenish-yellow liquid with a reddish hue.
Brewing Time: Celestial Seasonings recommends steeping Green Tea Antioxidant Supplement in boiling water for 2 minutes. I steeped both cups for the requisite 2 minutes.
Manufacturer: Celestial Seasonings
Caffeine: Yes.
If you have had the opportunity to enjoy a cup of Green Tea Antioxidant Supplement tea, please stop by and share your experience. Until then… Happy Tea Drinking!
Eleutherococcus senticosus (formerly Acanthopanax senticosus) is a species of small, woody shrub in the family Araliaceae native to Northeastern Asia. It is commonly called eleuthero, and was previously marketed in the United States as Siberian Ginseng as it has similar herbal properties to those of Panax ginseng. However, it belongs to a different genus in the family Araliaceae.
Reference: Eleutherococcus senticosus. (2010, April 8). In Wikipedia, The Free Encyclopedia. Retrieved 20:19, April 18, 2010, from http://en.wikipedia.org/w/index.php?title=Eleutherococcus_senticosus&oldid=354779930
**Tea was provided by Celestial Seasonings as a sample.


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City of Manhattan BeachHome Menu
City Calendar - Month View
Cultural Arts Commission Meeting
- Date: 08/19/2019 6:00 PM - 7:49 PM
- Location: Manhattan Beach City Hall
1400 Highland Avenue
Manhattan Beach, California 90266
The Cultural Arts Commission serves in an advisory capacity to the City Council and is responsible for developing a master plan for cultural arts in the City, encouraging and supporting art education programs in the community and schools, participating in the Arts in Public Places selection process, and assisting in the Art in Civic Spaces Program. The Commission consists of six (6) members: one (1) artist representative, one (1) from the business and development community, three (3) at-large members and one (1) student representative. The Commission meets on the third Monday of every month at 6:00 PM. Meetings are subject to change. Check the City Calendar to note any changes in the Commission meeting schedule.
For more information on the Cultural Arts Commission, check out the Cultural Arts Commission page.


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Lebanon Claiming Only It Owns Hummus, Falafel, Tabouleh And Baba Gannouj
from the make-it-stop deptAnother day, another ridiculous intellectual property lawsuit. Along the same lines as various regions in France declaring that only they can sell "Champagne" or Greece being the only one allowed to offer "feta," a group in Lebanon is claiming that various popular middle eastern foods such as hummus, falafel, tabouleh and baba gannouj are property of Lebanon and Lebanon alone. In fact, the group is planning to sue Israel for "stealing" its food. They're actually claiming that this could be a violation of a "food copyright" (something that doesn't actually exist). Specifically, the group says that since Israel sells such foods, it's taking "tens of millions of dollars" away from Lebanon, where those foods should be bought. This, folks, is what happens when you build up a society around the idea of "owning" infinite goods.
Filed Under: baba gannouj, falafel, food, food copyright, hummus, intellectual property, lebanon, tabouleh, trademark


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TV classics: Murder, She Wrote
USA 1984-96, 264 episodes, 12 seasons, 45 minutes each, CBS. Created by Peter S. Fischer, Richard Levinson, William Link, Producer: Angela Lansbury, Peter S. Fischer, Richard Levinson, William Link, David Moessinger, Music by John Addison. Cast: Angela Lansbury, William Windom, Tom Bosley, Ron Masak, Guest Stars: Julie Adams, June Allyson, Barbara Babcock, Gene Barry, Polly Bergen, Len Cariou, George Clooney, James Coburn, Courtney Cox, Marcia Cross, Mike Farrell, Michael Horton, Kim Hunter, Shirley Jones, Brian Keith, Dorothy Lamour, Martin Landau, Keith Michell, Kate Mulgrew, Leslie Nielsen, Jerry Orbach, Cynthia Nixon, Richard Paul, John Rhys-Davies, Wayne Rogers, Mickey Rooney, Jean Simmons, David Ogden Stiers, Loretta Swit et al.
Plot summary: JB Fletcher is a retired English teacher gone bestselling author who writes mysteries for a living and solves real murders after hours.
Review: Already looking back on a renowned career in Hollywood and on the Broadway stage, Angela Lansbury became a household name when she entered America's living rooms in the fall of 1984. As former English teacher gone mystery writer Jessica Fletcher, she won the hearts of audiences worldwide, solving crimes on paper and in person while sometimes butting heads with the police outside of her hometown Cabot Cove in Maine. Inquisitive by nature, Mrs. F found it hard to resist investigating the crimes she stumbled into, often bringing her own life in danger when she got too close to the truth.
Supported by some recurring characters, Jessica worked with her hometown sheriffs, Doctor Hazlitt, Scotland Yard and an agent from MI6. She solved murders on vacation and on book tours, found crimes that hit close to home but never got gritty. Her way of investigating was suspenseful yet family friendly. Murder, She Wrote was not CSI or Law & Order_ SVU. The show relied on strong performances and a whodunit story rather than violence and exaggerated action. JB Fletcher was a widow and retired teacher, she didn't carry a gun or used science jargon. She used her eyes and ears to observe and connect the dots – much like Miss Marple had, solving crimes a different way.
Always savvy, warm and assertive, Jessica Fletcher was a respected member of her community and extended family, always eager to expose the truth behind the crimes she got involved with. Angela Lansbury did a fine job creating one of TV's most beloved characters, a part that put four Golden Globes on her resumé and a record of twelve consecutive Emmy nominations.
Canceled due to time slot changes in 1996, Murder, She Wrote has remained a popular program in reruns and on DVD. Living on in a franchise that includes mystery novels, games and four TV movies, JB Fletcher is still a beloved member of many households around the world and continues to entertain her fans both young and old.


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PsyWeb Menu
Self Tests
Disorders and Treatment
- Mental Illness
- Depression
- Bipolar Disorder
- Mood Disorders
- Borderline Personality
- Schizophrenia
- Anxiety
- Mental Health Diagnosis
- Mental Health Treatments
- Alternative Meds
- Case Studies
General Depression
Brief periods of depression affect just about everyone at some point in time.
It may consist of a variety of negative emotions including sadness, feeling "blue" or "down in the dumps", pessimism, or a loss of interest in or pleasure from things that were once enjoyable. While most people are able to shake off these feelings and pull themselves out of a temporary depressive state, others are not. When those feelings persist or become serious enough to interfere with normal functioning, they are considered symptoms of a mental illness that is often referred to as "clinical depression".
Anyone, regardless of age, gender, race, or socioeconomic status, can suffer from depression. It is estimated that 19 million Americans suffer from depression every year. Depression is not a weakness or a character flaw; it is a true medical illness. People who have depression are not just moody or having "the blues" for a few days. They have long periods of feeling very sad and lose interest in social and daily activities.
Depression changes the way a person feels, thinks, and behaves. If left untreated, an episode of major depression typically lasts eight or nine months, and may even last for years. About 85 percent of people who experience one bout of depression will experience future episodes. The good news is that, with proper treatment, most patients will improve in time.
Depression is one of the most common mental illnesses. At least 8 percent of adults in the United States experience serious depression at some point during their lives, and estimates range as high as 17 percent. It affects all types of people, regardless of sex, race, ethnicity, or socioeconomic standing. However, women are two to three times more likely than men to suffer from depression. Experts disagree on the reason for this difference. Hormonal differences are believed by many to be a contributing factor. Men are also less likely to seek help or acknowledge their symptoms, because many associate them with weakness.
Depression occurs in all parts of the world, although the pattern of symptoms can vary. The prevalence of depression in other countries varies widely, from 1.5 percent of people in Taiwan to 19 percent of people in Lebanon. Some researchers believe methods of gathering data on depression account for the different rates.
A number of large-scale studies indicate that depression rates have increased worldwide over the past several decades. Furthermore, younger generations are experiencing depression at an earlier age than did previous generations. Social scientists have proposed many explanations, including changes in family structure, urbanization, and reduced cultural and religious influences.
Although depression may occur as early as childhood and well into old age, it usually begins during a person's 20s or 30s. Depressive symptoms appear suddenly, or start slowly and then gradually get worse over months or even years. A person who develops severe depression may appear so confused, frightened, and unbalanced that observers speak of a "nervous breakdown."
Surveys indicate that people commonly view depression as a sign of personal weakness, but psychiatrists and psychologists view it as a real illness. In the United States, the National Institute of Mental Health has estimated that depression costs society many billions of dollars each year, mostly in lost work time.
Despite the availability of effective treatment, many cases of depression are never diagnosed or treated. Studies indicate that general physicians fail to recognize depression in their patients at least half the time. In addition, many doctors and patients view depression in elderly people as a normal part of aging, even though treatment for depression in seniors is usually very effective.
Types of Depression
There are many different types of depression listed in the DSM – the "Diagnostic and Statistical Manual of Mental Disorders" used by mental health professionals. One of the most common types of depression – as well as one of the most serious – is Major Depression. Episodes of Major Depression may occur alone, or as part of Bipolar Disorder. It may develop postpartum, or occur in addition to more chronic and mild depression known as Dysthymic Disorder.
Following is a list of different names for various types of depression. Some of these terms, such as "primary depression" and "reactive depression" for example, are used to "qualify" the type of depression and aren't official diagnoses in and of themselves.
- Atypical Depression
- A type of major depressive or dysthymic episode characterized by an improvement in mood in response to positive events, along with hypersomnia (excessive sleep), significant increase in weight or appetite, chronic sensitivity to rejection, and / or a heavy feeling in the arms or legs.
- Bipolar Depression
- Depressive episodes that alternate with periods of mania or hypomania.
- Cyclothymic Depression
- Depressive episodes (that don't meet the criteria for Major Depression) that alternate with hypomanic episodes for a period of at least 2 years.
- Dysthymic Depression
- Depression that is chronic (at least 2 years of persistent symptoms) and milder than Major Depression.
- Endogenous Depression
- Depression that occurs with no obvious precipitating event or cause.
- Major Depression
- Depression characterized by significant feelings of sadness, hopeless, feeling "down", and /or a loss of pleasure or interest in most things.
- Postpartum Depression
- Depression that occurs in women within 4 weeks of giving birth.
- Primary Depression
- Depression that is not triggered by a medical condition or other psychiatric condition.
- Psychotic Depression
- Depression accompanied by delusions and/or hallucinations.
- Reactive Depression
- Depression that occurs in response to a stressful or traumatic event.
- Seasonal Depression
- Depression that occurs seasonally, usually during the fall and winter months when the days are shorter and there is less sunshine.
- Secondary Depression
- Depression that occurs due to a medical illness or other psychiatric illness.
- Unipolar Depression
- Major Depression in which there is no history of manic or hypomanic episodes.
Symptoms of depression may differ from person to person. They may range from mild to severe in terms of their impact. Common symptoms of depression include:
- Sadness
- Tearfulness
- Low energy
- Fatigue
- Irritability
- Hopelessness
- Feelings of worthlessness
- Excessive guilt
- Increase or decrease in appetite
- Sleep disturbances
- Difficulties concentrating
- Indecisiveness
- Restlessness or agitation
- Loss of interest in things that once brought pleasure
- Somatic complaints
- Frequent thoughts of death
- Suicidal thoughts and actions
Suicide and Depression
People who suffer from depression, particularly Major Depression, may experience such extreme emotional pain and hopelessness that they consider and / or attempt suicide. For them, ending their life seems to be the only solution or means of relief available. At least 15 percent of seriously depressed people do eventually commit suicide, and many more attempt it. Depressed individuals who are seriously considering suicide often need to be hospitalized.
Psychosis and Depression
In some cases, people with depression may experience psychotic symptoms, such as delusions (false beliefs) or hallucinations (e.g. hearing voices when there's no one else around or seeing things that aren't actually there). Psychotic symptoms usually only appear in the most severe cases of depression, and hospitalization is often necessary. Compared to other depressed people, those with psychotic symptoms have longer hospital stays, and after leaving, they are more likely to be moody and unhappy. They are also more likely to commit suicide. See Psychosis.
Factors that Influence Symptoms
Age - Symptoms of depression often vary by age. Children with depression often complain of stomachaches and headaches. They are often irritable, may "mope around," withdraw socially, and have changes in their eating habits. They may feel unenthusiastic about school and other activities. In adolescents, common symptoms include sad mood, sleep disturbances, and lack of motivation and energy. Elderly people with depression usually complain of physical rather than emotional problems, which can lead doctors to misdiagnose their illness.
Culture - Symptoms of depression can also vary by culture. In some cultures, depressed people may not experience sadness or guilt but may have physical complaints. In Mediterranean cultures, for example, depressed people may complain of headaches or nerves. In Asian cultures they may complain of weakness, fatigue or imbalance.
Causes and Contributing Factors
No one really knows for sure why some people are very resilient to depression despite their circumstances, while others are much more vulnerable. In many cases, the cause if often due to a variety of factors that increase one's risk. These include:
Life stressors
In some cases, depression seems to come out of the blue, even when things are going well. However, in many cases there is an obvious cause. Life stressors such as marital conflict, serious financial problems, or a significant loss (e.g. the death of a loved one or a break-up) may trigger depression. Traumatic events or a history of chronic trauma, such as childhood abuse or domestic violence, increases the risk of developing depression. Many people don't become depressed in response stressful events or trauma, but those who do may have a biological and / or psychological vulnerability to depression.
Depression tends to run in families. By studying twins, researchers have found evidence of a strong genetic influence in depression. Genetically identical twins raised in the same environment are three times more likely to have depression in common than fraternal twins, who have only about half of their genes in common. In addition, identical twins are five times more likely to have bipolar disorder in common. These findings suggest that vulnerability to depression and disorder can be inherited. Adoption studies have provided more evidence of a genetic role in depression. These studies show that children of depressed people are vulnerable to depression even when raised by adoptive parents.
Brain Chemistry and Hormonal Influences
Genes may influence depression by causing abnormal activity in the brain. Studies have shown that certain brain chemicals called neurotransmitters play an important role in regulating mood and emotions. Neurotransmitters involved in depression include norepinephrine, dopamine, and serotonin.
An imbalance of hormones may also play a role in depression. Many depressed people have higher than normal levels of hydrocortisone (cortisol), a hormone secreted by the adrenal gland in response to stress. In addition, an underactive or overactive thyroid gland can lead to depression.
Medical Issues as Causes of Depression
A variety of medical conditions can cause depression. These include dietary deficiencies in vitamin B6, vitamin B12, and folic acid; degenerative neurological disorders, such as Alzheimer's disease and Huntington's disease; strokes in the frontal part of the brain; and certain viral infections, such as hepatitis and mononucleosis. Certain medications, such as steroids, may also cause depression.
Anger and Response to Loss
Psychological theories of depression focus on the way people think and behave. In a 1917 essay, Austrian psychoanalyst Sigmund Freud explained depression as a response to loss - either real loss, such as the death of a spouse, or symbolic loss, such as the failure to achieve an important goal. Freud also believed that depression was essentially the result of "anger turned inward".
Negative or Irrational Thought Processes
Irrational thought processes often play a significant role in depression. American psychiatrist Aaron Beck proposed that depressed people tend to view themselves, their environment, and their future in a negative light because of errors in their thinking. These errors include focusing on the negative aspects of any situation, misinterpreting facts in negative ways, jumping to conclusions, catastrophizing things (i.e. "making mountains out of mole hills"), and feeling responsible for every bad thing that happens to them, even when it was beyond their control.
Most people learn these self-defeating ways of looking at the world during early childhood. These "cognitive errors" make situations seem much worse than they really are and increase the risk of depression, especially in stressful situations.
Personality Traits and Depression
People with certain personality traits tend to be more vulnerable to depression. These traits include gloominess, pessimism, introversion, self-criticism, excessive skepticism and criticism of others, deep feelings of inadequacy, sensitivity to rejection, brooding, and frequent or excessive worrying. In addition, people who regularly behave in dependent, hostile, or impulsive ways tend to have a greater risk for depression.
Learned Helplessness
American psychologist Martin Seligman proposed that depression stems from "learned helplessness," an acquired belief that one cannot control the outcome of events no matter what they do. In this view, prolonged exposure to uncontrollable and inescapable events leads to apathy, pessimism, and loss of motivation. People who feel they have some control over their lives and their future tend to be less prone to depression.
Loss of Hope
Many experts believe that depression results not only from a sense of helplessness, but also from a loss of hope. The hopelessness theory attributes depression to a pattern of negative thinking in which people blame themselves for negative life events, view the causes of those events as permanent, and over-generalize specific weaknesses as applying to many areas of their life. Loss of hope is believed to play a significant role in suicidal thoughts and behaviors.
Treatment for Depression
In most cases, depression can be treated successfully. Symptoms may not completely disappear for some people, but they can usually be significantly reduced with proper treatment. The two most common types of treatment are psychotherapy and medication. A combination of both may be necessary at times.
Most cases of depression can be treated on an outpatient basis. However, hospitalization may be necessary if:
- Symptoms are severe
- Functioning is significantly impaired
- There is a high risk of suicide
- Psychotic symptoms are present
Most experts agree that psychotherapy, or psychotherapy combined with medication, is more effective in the long-term treatment of depression than medication alone. This is likely due to several reasons. For example, psychotherapy can help people gain valuable insight into why they are depressed and make lasting changes in their thinking and behaviors as a result. Therapy can also help individuals with depression learn healthy coping skills, develop better interpersonal skills, feel more empowered, and change the way they look at themselves and life in general.
Studies have shown that short-term psychotherapy can relieve mild to moderate depression as effectively as antidepressant drugs. Unlike medication, psychotherapy produces no physiological side effects. However, psychotherapy usually takes longer to produce benefits. Therapy can be quite expensive and isn't always covered by health insurance. Unfortunately, this can be an obstacle to many people.
Cognitive Behavioral Therapy
While there are many different types of psychotherapy, research has shown that Cognitive Behavioral Therapy is one of the most effective types of therapy for the treatment of depression. Cognitive-behavioral therapy focuses on the negative and irrational thoughts and beliefs people have about themselves, their circumstances, their interactions with others, and their future. Cognitive therapists help them identify and eliminate these negative patterns and beliefs, and replace them with new, healthy, more positive and empowering thoughts and beliefs.
Interpersonal Therapy
In interpersonal therapy, the therapist helps a person resolve problems in relationships with others that may have caused the depression. The subsequent improvement in social relationships and support helps alleviate the depression.
Psychodynamic Therapy
Psychodynamic therapy views depression as the result of internal, unconscious conflicts. Psychodynamic therapists focus on a person's past experiences and the resolution of childhood conflicts. Psychoanalysis is an example of this type of therapy. While the insight derived from psychodynamic therapy can be beneficial, critics of long-term psychodynamic therapy argue that its effectiveness is scientifically unproven.
Up to 70 percent of people with depression respond to antidepressant drugs. These medications appear to work by balancing the levels of serotonin, norepinephrine, and other neurotransmitters in the brain. The positive effects of medication are usually not felt for at least 2 to 4 weeks.
Doctors cannot predict which type of antidepressant drug will work best for any particular person, so there is often a lot of trial and error involved before an effective and tolerable medication is found. Antidepressant drugs are not addictive, but they may produce unwanted side effects. To avoid relapse, people usually must continue taking the medication for several months after their symptoms improve.
Most antidepressant drugs fall into one of four categories:
- Selective serotonin re-uptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Tricyclics
- Monoamine oxidase inhibitors (MAO inhibitors)
- SSRIs
- SSRIs are the most frequently prescribed antidepressants. This is largely because they have the fewest side effects. They may also help alleviate symptoms of anxiety, which often accompany depression. As the name suggests, SSRIs are designed to primarily balance serotonin levels in the brain. Popular SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil).
- Potential side effects of SSRIs include insomnia, drowsiness, headaches, anxiety, and sexual dysfunction. Some patients, families of patients, and doctors have alleged that SSRIs cause violent or suicidal behavior in a small number of cases, particularly when prescribed to children and adolescents. The U.S. Food and Drug Administration has failed to substantiate this claim although there is some research that appears to support it.
- SNRIs
- SNRIs primarily target serotonin as well as another key neurotransmitter, norepinephrine. Doctors will often prescribe an SNRI antidepressant if SSRIs have been ineffective. FDA-approved SNRIs include venlafaxine (Effexor and Effexor XR), duloxetine (Cymbalta), and desvenlafaxine (Pristiq). Side effects may include drowsiness, dizziness, dry mouth, sexual dysfunction, insomnia, and nausea.
- Tricyclics
- Tricyclics, named for their three-ring chemical structure, include amitriptyline (Elavil), imipramine (Tofranil), desipramine (Norpramin), doxepin (Sinequan), and nortriptyline (Pamelor). Side effects of tricyclics may include drowsiness, dizziness upon standing, blurred vision, weight gain, nausea, insomnia, constipation, and dry mouth.
- MAO Inhibitors
- MAO inhibitors include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). People who take MAO inhibitors must follow a restrictive diet due to potentially dangerous interactions. They must avoid foods that contain tyramine - a substance found in wine, beer, some cheeses, and many fermented food - to avoid a dangerous rise in blood pressure. In addition, MAO inhibitors have many of the same side effects as tricyclics.
- Atypical Antidepressants
- Other antidepressants often used to treat depression, that don't fit into the above categories, include bupropion (Wellbutrin, Aplenzin), trazodone (Desyrel, Oleptro), and mirtazapine (Remeron). (SNRIs are sometimes included in the "atypical" category.)
- Addiction medications
- In some cases, an additional medication may be prescribed to help "boost" the primary antidepressant or to treat symptoms such as psychosis or mood swings.
- Mood stabilizers, such as lithium carbonate or valproic acid (Depakote), are typically prescribed for individuals with bipolar disorder (see Lithium). They are usually taken during periods of relatively normal mood to delay or even prevent subsequent mood swings.
- Antipsychotic medications, such as Seroquel and Abilify, are sometimes used as adjunct medications as well. The FDA has approved Symbyax, which combines and SSRI (fluoxetine) and an antipsychotic (olanzapine) for cases of treatment-resistant depression.
Electro convulsive therapy (ECT) is sometimes used to treat severe depression in people who fail to respond to medication and psychotherapy. In ECT, a low-voltage electrical current is passed through the brain for one to two seconds to produce a controlled seizure. Patients usually receive six to ten ECT treatments over several weeks. ECT remains controversial because it can cause disorientation and memory loss. Nevertheless, research has found it highly effective in alleviating severe depression. ECT is also referred to as "electroshock therapy".
Lifestyle Changes
For milder cases of depression, regular aerobic exercise may improve mood as effectively as psychotherapy or medication. In addition, some research indicates that dietary modifications can influence one's mood by changing the level of serotonin in the brain. Reducing and managing stress is also very beneficial for anyone struggling with or vulnerable to depression.
Related Articles
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I colored the image with my Spectrum Noir markers. Here's a list of what I used:
Flower petals: CR7, CR6, CR5, CR4
Flower center: JG2, GB5, CT4
Flower stem: JG2, JG1
Butterfly: GB5, CT4, CT3, CT2
Outline: GG2, GG1
I stamped the image twice - once on the die cut circle and then again on another piece of cardstock, and fussy cut it. I adhered it using foam tape, for dimenesion. And to add even more dimension to the butterfly, I put an extra piece of foam tape there, which help keep the wing popped up at an angle.
Stop by the sketch challenge forum and play along with us this week!
Stamps: Treasured (Sweet 'n Sassy Stamps)
Card Stock: Black (Recollections); White (Neenah)
Patterned Paper: Victoria Garden (Echo Park)
Ink: Tuxedo Black (Memento)
Coloring Medium: Spectrum Noir
Accessories: Half Pearls (Queen & Co)
Tools:Classic and Scalloped Circles (Nestabilities)


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Ziva disposable rain poncho with pouch. Poncho (90x120 cm.) with hood in a resealable pouch. Decoration on pouch only. PE plastic.
Clear disposable poncho in clear poly bag with digitally printed card insert. Poncho not printed directly.
PVC Poncho in an ABS plastic ball with a snap hook attachment.
Rain Poncho With Sticker. Clear plastic emergency rain poncho. One size fits all. Folded in a clear polybag which has a full colour printed sticker attached.
Xina rain poncho. One size fits all hooded poncho (90x120 cm.) for unexpected downpours. Conveniently compact container hooks onto a keychain, fits into a small pocket and is a great add on to any bag or drinkware piece. Decoration on container only. PS and PE plastic.
Perfect for unexpected showers, supplied with printed full colour insert.
Foldable plastic poncho with attached hood, packed in a transparent polybag.
Huko disposable rain poncho with pouch. Poncho (120x90 cm.) with hood. Includes a convenient, re-sealable pouch. Decoration on pouch only. PVC.
Transparent PE poncho wrapped in an AS ball shell with carabiner hook to hang on a belt or a bag.
PE Poncho in a plastic footbcll with coloured belt attachment.
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CANDIA — While conducting routine patrols in the area of several commercial and industrial businesses near Exit 3 off Route 101, several Candia police officers have reported a creepy sight, noting dozens of glowing eyes staring at them through the darkness. The source isn't monsters, goblins or boogie men. Rather, it's colonies of stray cats that have inhabited the area, and several other locations in town.
"To my understanding, it's a recent phenomenon. I'm not sure how long it's been going on, but it's really just come to our attention recently," Candia Police Chief Mike McGillen said.
"A lot of towns say they have a drug problem, but we joke that Candia has a cat problem," said Laura Masone, president of the Londonderry-based Animal Rescue Veterinary Services (ARVS) board, which has been offering Candia its complimentary services often in recent months. The nonprofit has sent volunteers to Candia to "trap, neuter and release," known as TNR. Feral felines are scooped up, spayed or neutered, vaccinated, nursed back to health and released where they were found. Kittens and felines maintaining friendly demeanors are kept and sent to animal rescue shelters, Masone said.
"Often times we get calls from property owners or neighbors saying they have strays in their yard and they don't know what to do," said Masone. "A lot of times these strays aren't very friendly anymore, so we can't just go in and pick them up. We have to use humane traps." Masone said her organization has recently addressed four or five large colonies in Candia, some with up to 30 felines.
"They've done dozens of (TNRs) to help us out here in Candia," McGillen said. "I certainly support the concept and think it's a good idea." In addition to a commercial/industrial area on the west side of town near Auburn, McGillen said his department has received several reports of stray cats in residential and rural areas throughout town. Masone said similar issues exist throughout the state.
"We've been all over Southern New Hampshire, from Antrim to Pembroke, Allenstown, Salem, I mean, we've pretty much been everywhere," said Masone, who noted Hooksett is among the areas her organization is called to the most. "We get calls from animal control officers and concerned residents, and often times, by the time they've found us, they've called everybody else and nobody else is doing this," she said. "We're really the only ones in New Hampshire offering this."
ARVS uses grants and donations to pay for its facility and a full-time veterinarian, who conducts what Masone termed "high volume, high quality spay and neutering." The rest of the organization is made up of volunteers, including four or five technicians who assist the veterinarian, who performs up to 30 procedures a day.
"The biggest thing we recommend is early spaying and neutering," Masone said. "The problem is people don't typically spay or neuter early enough. We recommend before six months of age because females can actually go into heat around five months, so this alleviates a lot of problems like fighting, spraying and unintended or unwanted litters. It's just better to do it right away."
ARVS also performs low-cost spaying and neutering for pet owners at its clinic at 194 Rockingham Road in Londonderry. Additional savings options and are available through the New Hampshire Society for the Prevention of Cruelty to Animals (NHSPCA) Plan B program, which aims to control animal populations. Masone urged anyone who finds stray cats in town to avoid feeding them and to contact the Candia Police Department at 483-2318.
For more information on ARVS or to donate to its efforts, visit www.arvsonline.org or email firstname.lastname@example.com.
By RYAN O'CONNOR, Union Leader Correspondent
Originally published May 28, 2014 in the Manchester Union Leader.


text:
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text:
In starting his second term, President Obama took the oath of office not on one Bible but two – those of Abraham Lincoln and Dr. Martin Luther King Jr. Then, in his inaugural address, he spoke of God five times and freedom seven times. He did so mainly to underscore this point: Americans "must act on behalf of those who long" for the freedoms that are a gift from God.
To help prove his point, Mr. Obama kicked off the three-day Inauguration weekend by participating in the National Day of Service – along with some 13,000 other people nationwide – in an event that yearly honors the King holiday. With his family, he stained a bookshelf at a local school.
Action is now Mr. Obama's second-term theme, not only action by government but "collective action." Every citizen has the power to set the country's course, he stated. The gap between the nation's ideals and its reality is too great for people not to act.
The president's call to action reveals the depth of his personal empathy for those who have not yet fully realized "Life, Liberty, and the Pursuit of Happiness." And as studies show, leaders who display empathy are more effective as leaders. Other research shows that people who witness good deeds – even if only through the news media – are more likely to perform good deeds themselves.
Each new leader builds on this kind of "moral elevation." Reverend King had a vision of Americans as a "beloved community." One of his last sermons read, "The question that the lord of the universe is asking now, and will ask forever, is what did you do for others."
Lincoln sought to unify a nation torn apart over slavery by appealing to the "better angels of our nature." He achieved it.
Obama's vision lies in the nation acting "now" on its founding creed of rights for all. His compassion is as evident as his impatience for results. Or as American essayist Susan Sontag wrote: "Compassion is an unstable emotion. It needs to be translated into action, or it withers."
To whom will Obama's message most appeal? Perhaps most of all it is to that generation which is the most service- minded since World War II – the so-called Millennials, born between 1981 and 2002.
By next year, this group of 92 million will represent half of the workforce. They were raised on doing public service. They buy fair-trade goods, ride bikes to work, join Teach for America, or help out after a big storm. More than a quarter of college students regularly volunteered in 2010. This "civic generation" is happiest in their jobs when they participate in workplace volunteer activities, one study finds.
The emergence of Millennials in society may help explain why volunteering reached a five-year high in 2011. More than one in four adults volunteered through a formal organization while 2 out of 3 did favors for neighbors.
Yet they also see personal acts of caring as not dependent on institutions, such as government or organized religion. (Only 19 percent of businesses provide paid time off for volunteering.)
The Millennials are also marked by another big qualifier. They are more religiously unaffiliated than previous generations of young people. A third of them are "nones," or none of the above on questions of religious association.
This does not mean they are all secularists. In fact, if the service-mindedness of the nones can be explained, it lies in the fact that more than two-thirds believe in God or a higher power. And 41 percent say they pray.
As a Pew study of the "nones" states, "not belonging does not necessarily mean not believing." They are as unwilling to embrace atheism as they are a local church.
If Obama is to tap this generation for action, he must appeal to their beliefs in a love higher than themselves and one that is expressed more heart to heart than through organizations.
A 2009 survey of adults by the University of Akron found people who most often reported feeling God's love were more than twice as likely as the average American to give time to those in need more than once a week. Or, as philosopher Roy Brand writes in a new book, "LoveKnowledge": "Love is not something to know, but something to live by and act. Love demands love, not knowledge, as a response. It cannot be explained, only performed."
The American concept of rights is really only one step in humanity's long journey to show that kindness and caring come not from genes but is a way to overcome the notion that genes determine behavior. To fulfill such an ideal is first of all an act of understanding this universal love, then acting to see it fulfilled in one another's good.
This is the highest ideal to achieve a nation's unity. Or as Obama said in his address: "Now, more than ever, we must do these things together, as one nation, and one people."
He stated that soon after lifting his left hand from the personal Bibles of two leaders who also inspired others to act.


text:
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WakePup2 v0.2 - Floppy boot disk (or boot CD) for Puppy2
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Joined: 04 Jun 2005
Posts: 1156
Location: Sweden
Posted: Fri 12 May 2006, 05:17
Post subject:
WakePup2 v0.2 - Floppy boot disk (or boot CD) for Puppy2
is a boot disk using FreeDOS that can boot Puppy2 from built-in hard disk and CD-ROM drives as well as USB hard disk, CD-ROM and flash drives. It will run from floppy disk or CD. Except for the drivers, WakePup2 uses only GPL'd software or freeware.
See also
WkPup2x v0.2
, for a special version of WakePup2 that can boot puppy from USB devices attached to a PCMCIA USB2 adapter in your laptop. Useful if you laptop doesn't have USB ports or just to speed up booting if the built-in laptop ports are only USB1. You can boot it from floppy or, if your laptop supports it, boot from CD.
Barry has conveniently put a floppy disk image of WakePup2 in Puppy2alpha-7may06. Unfortunately, that early version has a bug in it that prevents the boot option (acpi=on or acpi=off) from working. Use this version instead.
While fixing the bug, I took the opportunity to improve WakePup2 somewhat.
- I have extended the drive letters that get searched for Puppy2 files to the maximum for those cases where the hard disk(s) has/have many partitions (C through W for IDE/USB drives not including CD-ROM and X through Z for CD-ROM). If you have two IDE CD-ROM drives (not uncommon today), the first one gets drive letter X, the second Y. If a USB CD-ROM is found, it gets drive letter Z.
- There are now three boot options:
1. acpi=on Default for newer PCs (made 2002 or later)
2. acpi=off For older PCs, or use if acpi=on causes problems
3. acpi=force Needed to force acpi=on on older PCs
- I have also made an iso image of WakePup2 for those who have PCs that can boot from CD
but not USB
. Ideal to put on a mini-CD to carry along with a USB flash pen containing Puppy2 and your personal files.
How to make a WakePup2 floppy disk
With a formatted 1.44MB diskette in the floppy drive, do one of the following:
1) In DOS/Windows, unzip WKPUP202.ZIP in a temp dir and execute MAKEDISK.BAT
2) In Linux, copy WKPUP202.ZIP to a temp dir and execute:
# unzip WKPUP202.ZIP
# dd if=WKPUP202.IMG of=/dev/fd0 bs=1440k
Using WakePup2
I have provided the marker files IDEHD, USBHD and USBFLASH for convenience on the WakePup2 floppy. Just copy the one you need to the drive you want to boot from containing the Puppy2 files [INITRD.GZ, PUP_xxx.SFS and VMLINUZ]. The CD-ROM doesn't need a marker file.
Examples of booting Puppy2 with WakePup2:
- Boot from a built-in hard disk: copy the IDEHD marker file to the hard disk partition containing the Puppy2 files, then boot using WakePup2.
- Boot from a USB hard disk: copy the USBHD file to the hard disk partition containing the Puppy2 files, then boot using WakePup2.
- Boot from a USB flash pen: copy the USBFLASH file to the same location as the Puppy2 files on the drive, then boot using WakePup2.
- Boot from a built-in IDE or external USB CD-ROM: no marker file is needed - WakePup2 should find the Puppy2 files anyway.
WakePup2 will pause after the USB driver has scanned for USB devices.
If it detects one
, it will print a short id string.
If not
, it will print "Target USB device not found".
- WakePup2 can only find Puppy2 files on DOS (FAT16 or FAT32) formatted partitions.
- WakePup2 does not seem to work with some USB flash drives. It seems to be dependant on the make of the controller chip used in the drives.
- If WakePup2 cannot find your USB flash device, it may help to reformat it (FAT16, or FAT32 if the drive is 4GB or larger) .
[Edited post to correct links and update text]
WakePup2 iso image - burn to CD. Note: the burned CD will appear empty because WakePup2 is in the CD boot track.
14192 Time(s)
WakePup2 for floppy disk - contains a batch file to make the floppy.
51261 Time(s)
Last edited by pakt on Wed 18 Mar 2009, 13:43; edited 8 times in total
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Joined: 24 Aug 2005
Posts: 13647
Location: Karlsruhe, Germany
Posted: Fri 12 May 2006, 05:25
Post subject:
Have you seen the news already?
May 12
Now that pakt's WakePup2 is in the live-CD, it needs a frontend GUI, so I have written one, that is run from the menu "Setup --> WakePup create boot floppy".
The Puppy Universal Installer has been upgraded to integrate usage of GParted and WakePup.
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Official Crustacean
Joined: 04 May 2005
Posts: 15588
Location: Paradox Realm
Posted: Fri 12 May 2006, 05:31
Post subject:
Is this a case of great minds thinking alike?
I feel the work you have done will be very useful to those using existing Puppys . . .
Puppy Raspup 8.2
Puppy Links Page
Last edited by Lobster on Fri 12 May 2006, 07:06; edited 1 time in total
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Puppy Master
Joined: 09 May 2005
Posts: 9400
Location: Perth, Western Australia
Posted: Fri 12 May 2006, 05:49
Post subject:
I'm just putting in some infrastructure to fully utilise WakePup2 and GParted,
now that they are in Puppy2 iso file.
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Joined: 04 Jun 2005
Posts: 1156
Location: Sweden
Posted: Fri 12 May 2006, 05:54
Post subject:
MU wrote:
Have you seen the news already?
May 12
Now that pakt's WakePup2 is in the live-CD, it needs a frontend GUI, so I have written one, that is run from the menu "Setup --> WakePup create boot floppy".
The Puppy Universal Installer has been upgraded to integrate usage of GParted and WakePup.
That's funny
What a coincidence! Great news that Barry has made a frontend GUI for it
I've just spent a few hours preparing the wakepup2 package and composing the text for the forum, so I hadn't checked the news or the forum 'till now.
Last edited by pakt on Wed 18 Mar 2009, 04:44; edited 1 time in total
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Joined: 04 Jun 2005
Posts: 1156
Location: Sweden
Posted: Fri 12 May 2006, 06:06
Post subject:
Lobster wrote:
Is this a case of great minds thinking alike?
I feel the work you have done will be very useful to those using exiting Puppys . . .
It seems WakePup for Puppy1 was very successful - iirc, it had been downloaded at least two thousand times last time I looked. I was especially pleased to get this post from dustypenguin:
dustypenguin wrote:
I just wanted to thank you for wake pup. That amazing piece of software allowed me to install puppy on a Compaq 4220 that can not boot off the CD. Even more amazing is it allowed me to install puppy on a couple of old (233 MHz) donated computers with dead, non-repalceable bios batteries. These computers could not even tell themselves that they had hard drives or CD Drives, but wake pup found both! With some scripts that update the time and date at boot, wake pup boots these machines and they are used as internet access and light word processing machines in the library of the mission school here in Niger.
Systems Administration
SIM Niger
Niamey, Niger, West Africa
Lobster wrote:
exiting Puppys
Er, 'exiting Puppys' ? Is this a new breed
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Joined: 04 Jun 2006
Posts: 3
Posted: Sun 04 Jun 2006, 12:11
Post subject:
I downloaded puppy 2.0 seamonkey. I have a k6 233 with only 32mb ram with floppy and without cd-rom.
Wakepup2 run but the software want to mount puppy in ram , how i change this to mount in hd?
Thank You
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Joined: 10 Aug 2006
Posts: 10
Location: NY
Posted: Fri 11 Aug 2006, 19:45
Post subject:
Thank U so so much for this!! I computer would not boot to any CDs at all and it booted right up with wakepup2 0.2!!!
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Joined: 19 Aug 2006
Posts: 2
Posted: Sat 19 Aug 2006, 16:13
Post subject:
First of all I too want to say how great this thing works
second... I know this is not puppylinux related as such but I was wondering
if the wake2pup could be comfigured to boot GeexBox from usb as well
(as it also has an optional installation to boot from usb)
thanks in advance
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Joined: 03 Aug 2006
Posts: 9
Location: Sweden
Posted: Fri 01 Sep 2006, 04:15
Post subject: hrm...
So, I figured I'd try puppy on one of my dear shools computers.. it cannot boot from cd (the bios is passwd protected of course...) so I use the wakepup provided here it boots just fine but does not seem to find the Cdrive...? (nor the internal harddrive...) It just tells me "Hmm... Wakepup was unable to find the puppyfiles anywhere..."
(I realise I cannot be helped whitout providing descriptions of the cddrive of the matter but the comp. seem quite reluctant to hardwareprobing...)
(btw) sorry if this is the completely wrong place to post this I only just realised that this is an "Announcements" section...)
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Joined: 04 Jun 2005
Posts: 1156
Location: Sweden
Posted: Fri 01 Sep 2006, 05:20
Post subject: Re: hrm...
HappyPuppyUser wrote:
So, I figured I'd try puppy on one of my dear shools computers.. it cannot boot from cd (the bios is passwd protected of course...) so I use the wakepup provided here it boots just fine but does not seem to find the Cdrive...? (nor the internal harddrive...) It just tells me "Hmm... Wakepup was unable to find the puppyfiles anywhere..."
(I realise I cannot be helped whitout providing descriptions of the cddrive of the matter but the comp. seem quite reluctant to hardwareprobing...)
(btw) sorry if this is the completely wrong place to post this I only just realised that this is an "Announcements" section...)
If you have made the Puppy boot CD correctly from the iso file and you have put the CD in the CD-ROM drive, WakePup2 should find Puppy on the CD and boot from it.
The only other possible problem I can see is if the CD-ROM drive has problems reading the CD. In that case, you might try burning Puppy on another brand of CD or burn at a lower speed.
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Joined: 18 Sep 2006
Posts: 1
Posted: Mon 18 Sep 2006, 04:44
Post subject:
Does anyone know if wakepup2.02 works with Puppy2.10? Or will wakepup require an update to work?
I would try it myself, but I don't have a floppy drive handy. I'm trying to advise a friend who is new to linux and has an old laptop which can't boot from CD.
Thanks much.
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Joined: 14 Jan 2007
Posts: 1
Posted: Sun 14 Jan 2007, 02:11
Post subject: Message "LINLD can't read first KB"
When I run wakepup 2 with puppy 2.12 in a cd-rom drive, it successfully finds the files on the cd-rom (drive X), but after choosing a boot option (I have tried all 3) I get a message saying "LINLD can't read first KB". Any ideas?
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Sit Heel Speak
Joined: 30 Mar 2006
Posts: 2595
Location: downwind
Posted: Sun 14 Jan 2007, 21:44
Post subject:
1. Check its md5sum to make sure you got a good download. In Windows, Google to find md5sum.exe, download it, open a DOS window and issue
md5sum puppy-212-seamonkey.iso
(name may be slightly different) (and you must be in the correct subdir).
Or, in Puppy, menu-file manager-Roxfiler, navigate up and over to the subdir where you downloaded the .iso, right-click-on-whitespace, Window-open terminal window here (or similar) and issue the command
md5sum puppy-212-seamonkey.iso
The return code string from md5sum should match the text of puppy-212-seamonkey.iso.md5 from where you downloaded it (again, names may be slightly different).
2. There are two ways to burn an .iso image to CD.
One way is to burn the .iso file directly (a directory listing will show puppy-212-seamonkey.iso) (in TkDVD this is the "Burn files and folders on a CD/DVD" option). This is the wrong way.
The other option is "Burn iso9660 image." Afterward, a directory listing will show vmlinuz, initrd.gz, pup_212.sfs, and others. This is the correct way.
Hope this helps. Welcome to the kennels.
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Joined: 26 Jan 2007
Posts: 15
Posted: Fri 02 Feb 2007, 03:05
Post subject: Wake-Pup has Given life to my Puppy options
Subject description: Video options
Wake pup have given life to my Old Laptop.
Can you suggest if I can control the load of FB800x600 so the video will work with the Dell Latitude LM? specifically, Is there a way to allow a user option on the menu for Frame buffering of video?
It appears that the video selection video=VGA has been coded in the Wake pup or accompaning files. My old box need frame buffering. After the full load of pup202, the screen is yellow and green and I can make out only a few images or menus.
I believe the opening screen is video options but I need to set FB on os load (i think)
Last edited by marc66thomas on Fri 02 Feb 2007, 14:21; edited 2 times in total
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I am amazed by the number of tea contests that are going on for the holidays! Not only are they fun and easy to enter… the prizes are amazing! Especially, the prize pack for The Ultimate Holiday Tea Contest sponsored by Steepster. There are two ways to enter: 1. Follow Steepster on Twitter and tweet the verbiage below; or 2. Post a reply to the Ultimate Holiday Tea Contest Discussion on Steepster.
Everyone who enters the The Ultimate Holiday Tea Contest has a chance to win. The contest winner, selected by random drawing, will receive the complete prize bundle, which includes the Sorapot designed by Joey Roth along with other fantastic accoutrements to the modern tea experience.
- The contest is open to residents of U.S. or Canada, 18 years of age or older (sorry international friends, shipping costs and restrictions are a bummer).
- The contest ends at 8PM EST on 12/18/09, after which we'll select one winner at random and contact them through Twitter or email, depending on how they entered.
- The winner must respond with their full name and a valid mailing address (no P.O. boxes) within 72 hours of notification in order to receive their prize, otherwise he/she will no longer be eligible and a new winner will be chosen.
Visit The Ultimate Holiday Tea Contest on Steepster to enter and win!


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Curvy 3D 4.0 will have more primitive types and better control over their creation.
Here is an example Cylinder with variable resolution, to allow for low-poly items as well as easier to sculpt hi-poly objects.
Software for Artists - Aartform Curvy 3D
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text:
Chevrolet released its latest Super Bowl ad on Friday.
Featuring a postapocalyptic world with plenty of computer-generated imagery and chaos, out of the rubble pulls the new Silverado looking no worse for wear, other than a fine coat of dust.
As Barry Manilow's "Looks Like We Made It" plays on, the driver and his dog meet with a small collective of other Chevrolet pickup drivers.
Wondering where their lost companion Dave is, a survivor explains that "Dave didn't drive the longest-lasting, most dependable truck on the road. Dave drove a Ford."
The legal department made sure to include the small text at the bottom of the screen: "Dependability based on longevity: 1981-July 2011 full-size pickup registrations."
What the ad fails to mention is sales figures: For 2011 alone, the Ford F-Series outsold the Silverado, 584,197 to 415,130.
If you can't get enough of Super Bowl car ads, check out our video slideshow of all the automotive Super Bowl commercials released so far at shopautoweek.com.


text:
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence® Control siRNA (Unconjugated) #6568 (-), SignalSilence® PKCε siRNA I (+), or SignalSilence® PKCε siRNA II #12318 (+), using PKCε (22B10) Rabbit mAb #2683 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The PKCε (22B10) Rabbit mAb confirms silencing of PKCε expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.
Product Information
CST recommends transfection with 100 nM SignalSilence® PKCε siRNA I 48 to 72 hours prior to cell lysis. For transfection procedure, follow protocol provided by the transfection reagent manufacturer. Please feel free to contact CST with any questions on use.
Each vial contains the equivalent of 100 transfections, which corresponds to a final siRNA concentration of 100 nM per transfection in a 24-well plate with a total volume of 300 μl per well.
SignalSilence® siRNA is supplied in RNAse-free water. Aliquot and store at -20ºC.
SignalSilence® PKCε siRNA I from Cell Signaling Technology (CST) allows the researcher to specifically inhibit PKCε expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery of double stranded RNA molecules into the cell. All SignalSilence® siRNA products from CST are rigorously tested in-house and have been shown to reduce target protein expression by western analysis.
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Activation of protein kinase C (PKC) is one of the earliest events in a cascade that controls a variety of cellular responses, including secretion, gene expression, proliferation, and muscle contraction (1,2). PKC isoforms belong to three groups based on calcium dependency and activators. Classical PKCs are calcium-dependent via their C2 domains and are activated by phosphatidylserine (PS), diacylglycerol (DAG), and phorbol esters (TPA, PMA) through their cysteine-rich C1 domains. Both novel and atypical PKCs are calcium-independent, but only novel PKCs are activated by PS, DAG, and phorbol esters (3-5). Members of these three PKC groups contain a pseudo-substrate or autoinhibitory domain that binds to substrate-binding sites in the catalytic domain to prevent activation in the absence of cofactors or activators. Control of PKC activity is regulated through three distinct phosphorylation events. Phosphorylation occurs in vivo at Thr500 in the activation loop, at Thr641 through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660 (2). Atypical PKC isoforms lack hydrophobic region phosphorylation, which correlates with the presence of glutamic acid rather than the serine or threonine residues found in more typical PKC isoforms. The enzyme PDK1 or a close relative is responsible for PKC activation. A recent addition to the PKC superfamily is PKCμ (PKD), which is regulated by DAG and TPA through its C1 domain. PKD is distinguished by the presence of a PH domain and by its unique substrate recognition and Golgi localization (6). PKC-related kinases (PRK) lack the C1 domain and do not respond to DAG or phorbol esters. Phosphatidylinositol lipids activate PRKs, and small Rho-family GTPases bind to the homology region 1 (HR1) to regulate PRK kinase activity (7).
Explore pathways + proteins related to this product.
UniProt ID: Q02156
Entrez-Gene Id: 5581