African Americans (AA) have higher incidence and mortality rates for several cancer types in comparison to their European American (EA) counterparts. Increasing participation in clinical research and patient registries, related to precision cancer medicine, will significantly improve cancer health equity. Many AA cancer patients are treated in community oncology clinics. Unfortunately, these health systems have limited access to Clinical Laboratory Improvement Amendments (CLIA) next generation sequence (NGS) germline and somatic DNA and RNA testing that are used to inform oncologists on the best treatment and/or clinical trial options for cancer patients. Indeed, AA CLIA NGS sample sets are poorly represented, which could presumably result in incomplete knowledge of genomic variants that could affect their treatment and overall outcomes. Hence, it is crucial to implement CLIA NGS efforts for all cancer patients. To address these disparities, Morehouse School of Medicine has formed the Comprehensive Approach to Reimagine health Equity Solutions (CARhES) consortium with Tuskegee University that has engaged community oncology practices in Alabama and Georgia - two of five Black Belt states. The CARhES consortium aims to implement precision cancer medicine to underserved and underrepresented communities that will improve the standard of cancer care by providing access to CLIA NGS testing, clinical trials, and personalized cancer care. Here we describe the first proof of concept of this approach with community oncology partners, i.e., Grady Health System, Wellstar Health System, Georgia Urology, Midtown Urology, and Maui Memorial Medical Center. At the time of consent, saliva, buccal, and tumor samples were collected from participants. Germline and somatic CLIA NGS was performed, and medical reports were returned to practitioners within 14 days. Prior to the COVID pandemic, the study enrolled over 880 patients with a 88% consent rate (n = 1000) in the first 11months of the program. At the start of the COVID pandemic, recruitment efforts were suspended for four months with a slow restart by June 2020. A decrease in the number of staff, office visits (67% reduction), and increase in COVID cases significantly limited recruitment efforts. During this slowdown, we established and improved eConsenting capabilities, which exist today. Community anxiety, due to the pandemic and SARS-CoV-19 vaccine efforts, resulted in a significant reduction in consent rates (88% to 60%). Nevertheless, this study began in April of 2019 and consented 1,750 participants in less than 2 years. Taken together, our study shows that a community-focused precision medicine approach requires meeting people where they are and providing them with access and understanding the benefit of clinical trial participation. The approximate 2,000 clinically annotated genomic AA datasets will greatly contribute to our understanding of cancer health disparities and among the first steps to democratize precision medicine.
 This study was funded by the American Association for Cancer Research, The Pelotonia Foundation, the M2Gen Foundation, and the National Cancer Institute (U54CA118638).
 Citation Format: Latrisha L. Horne, Gabriella M. Oprea-Ilies, Eddie R. Stanley, Carla M. Holloway, Margaret P. Hooker, Amina Isom, Derrick J. Beech, Ana Gaonkar, Shavette Harden, Jeffrey F. Hines, LaTonya Randolph, James K. Bennett, Daniel Canter, Darrell J. Carmen, Pooja Mishra, Giuseppe Del Priore, Roland Matthews, Brian M. Rivers, James W. Lillard. AACR President's initiative - 2020 by 2020: Democratizing precision cancer medicine and advancing health equity in the black belt [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB173.


This collapsing kauri dam was built by Joan Tollenaar's Irish ancestor, John Patton, at Puketui on the Tairua River, Coromandel. In the 1980s Joan and her husband visited the dam, and did more than a short bush walk.


This paper is concerned with identifying Granger causality in the volatilities of returns between the Australian equity and debt markets. Using a bivariate stochastic volatility model previously described by Yu and Renate (2006), we estimate and compare four causal models between equity market volatility, and the short term and long term debt market volatilities. The causal models are compared with two non-causal, bivariate stochastic volatility models. Models comparisons are performed using the Deviance Information Criteria (DIC). Modelling results suggest that bond market volatility Granger causes equity market volatility. Equity volatility and money market volatility show evidence of Granger causality between the two, but no dominate causal direction is identified suggesting causal feedback between the two market volatilities.


Use of global positioning system (GPS) for guidance and control functions is of increasing interest to the aviation industry. Many levels of solutions exist, from the relatively simple to highly complex integrated systems. This presentation examines three different GPS approaches to determining the relative separation between two aircraft. It presents flight test data showing the errors in each of the three approaches, tradeoffs in selecting from these three approaches, and the simplifying assumptions made for implementing applications that may reduce the requirements and therefore the cost of using them.


The purpose of this article is to explore the lawfulness and conkret problem of 'The special law for traffic accident treatment'(hierafter The Law) and to present the rational judical measures to improve law enforcement. The Law is made and performed under the aim of punishment-exeption of offender and promoting promptly restoration of victim. Nevertheless, this aim might be hard to achieve. The reason for that come from theoretically and practically aspect. One is 'no punishment against victim's will', for that the victim hardly receive effective protect under the provision. And on the other hand, the punishment-execption result in weakness of abiding by law awareness. This article analyze particularly critical and present a guideline for the criminal treatment against traffic accident. As a result, in principle, the treatment of offender is regulated not special law, but criminal law. The Crime types related to 'no punishment against victim's will' should be strictly defined. Moreover, specified treatment is required according to individual act type.


This is pdf of a country list with HDI, iHDI, MPI and Gini. This file is now superseeded by DOI: 10.5281/zenodo.3908363, see https://docs.edtechhub.org/lib/55A44ZRB (which will also be available as a data file).


Abstract Over the last decade, network analysis has developed as an approach within digital humanities as a wider array of tools has become available to humanities scholars, and these approaches are now beginning to make an impact on the disciplines of history and English. This article presents an overview of different ways of approaching network analysis. It assesses recent projects to see how they accounted for gender in their datasets and what can be learnt about early modern women from these projects. It then looks at how projects in Ireland are engaging with network analysis, discussing the approaches used by RECIRC and introducing MACMORRIS's analysis of the Dictionary of Irish biography (D.I.B.) and the Bardic Poetry Database (B.P.D.), looking at how the latter is attempting to overcome the unconscious gender bias inherent in the D.I.B.'s selection of early modern lives from the period between 1541 and 1660. Finally, it points to some of the wider issues we as scholars face when engaging with this methodology, such as access to the required training and collaboration, arguing that while these are not unique challenges to the study of gender history in Ireland, they are important debates that can enhance scholarship in the field.


A new soluble, low band-gap polymer, poly(2,3-dihexylthieno[3,4-b]pyrazine)2b, which is dark blue–black in the neutral state and which becomes transparent light yellow when doped has been prepared; it has a doped film conductivity of 3.6 × 10–2 S cm–1 and a band-gap (film) of ca. 0.95 eV making it one of the lowest band-gap polymers prepared to date.


The invention provides a foldable vehicle which comprises a front chassis, a rear chassis, a connecting folding component and a steering system. The front chassis and the rear chassis are hinged to each other. An accommodating groove is formed in the front chassis. The steering system is connected to the front chassis through the connecting folding component. The front chassis is overlapped with the rear chassis under a folded state. At least part of the steering system is disposed in the accommodating groove. The foldable vehicle has the advantages that the foldable vehicle is good in size reduction effect under the folded state, and carrying and storing of the foldable vehicle are facilitated. The invention further provides the steering system suitable for the foldable vehicle.


Advanced machine learning algorithms and sen-sors provide the opportunity of automatically assessing rehabilitation exercises to assist therapist's management on patient's rehabilitation programs. However, despite recent advances in machine learning, AI systems cannot perfectly reproduce therapist's assessment on patients' diverse condi-tions. This paper presents an interactive hybrid approach that can complement an imperfect machine learning model with a rule-based model for more accurate rehabilitation assessment, and demon-strates the effect of accommodating therapist's feedback on an AI-based system to assess stroke rehabilitation exercises. This work discusses the importance of augmenting an imperfect machine learning model with expert's knowledge for more accurate decision making.


The most important area of resource conservation is the extensive use of secondary products of the industry as feedstock to produce building materials. Benefits of secondary products usage are to enhance the physical and mechanical characteristics and strength characteristics of the resulting building materials. By-products of different sectors of industry, such as ash and slag waste from combined heat and power systems and glass industry cullet, which provide the industry with huge sources of cheap and prepared raw materials, are used as accessory materials. They reduce the cost of producing certain materials. Three main mixtures are addressed in the article: (1) a mixture of cement, ash and slag waste and glass cullet, (2) a mixture of clay and ash and slag waste, and (3) a mixture of clay, ash and slag waste and glass cullet. The production processes of the tested materials are described: preparation and thermal treatment of raw materials. Material properties obtained after the roasting were determined: compression capacity, absorption of water and level of firing shrinkage. Not all materials are amenable to characterization techniques used in standardized ways of testing.


Native peoples in Canada are Indians,Inuits and Metis.This essay analyzes the changing position and the status of the native women in the periods from the early matriarchal society to the end of the 19th century,and studies the changes of their self-awareness,the conditions of lacking the senses of women's rights,the elements that caused the conditions,and the historical reasons why modern feminism had not brought quick impact upon native women.The article finally points out how to treat ethnical and gender issues objectively and rationally.


The equilibrium charge state distributions of He ions emerging from surfaces of Pb, Sn and Al targets were measured in the energy range 0.8-2.3 MeV. Fresh surfaces of these targets were prepared by continuous evaporation during the measurement. As the evaporation rate was increased, charge state distributions changed gradually and reached the equilibrium ones which were characteristic of the respective targets. The results were compared with the calculation based on the gas model using Bohr's cross sections. The present data support oscillatory behaviour of mean charge with increasing target atomic number.


Wind turbine is a device which converts kinetic energy from the wind into electrical power. Wind turbines generate electricity through asynchronous machines that are directly connected with the electricity grid. Composite wind turbine blades have high strain energy because it has less Young's modulus and density compared to Aluminum turbine blade. Due to light weight and non-corrosiveness in nature the life and durability is high. A Composite material is made by combining two or more dissimilar materials. They are combined in such a way that the resulting composite passes superior properties which are not available with single constituted material. Composite material plays an important role in automobile industry, aerospace application because of its exotic properties like high strength, erosive resistance and light weight. The goal of this project is to develop the geometry of the wind turbine blade, to improve the capacity, strength and to reduce weight. Initially literature survey and data collection has been done to understand the problem rectification methodology and selection of material. 3D model has been prepared using CMM points collected from NACA specifications. Different types of geometry's are implemented on the same and exported to Ansys for further study. A structural analysis is done on various geometric profiles of blade segment @200 Kmph and 400 Kmph (double velocity) for the validation. It is observed that the deflections of composite turbine blade are greater and stresses are less as compared to aluminum turbine blade for the same loading conditions. A 15% reduction in weight can be obtained by replacing an aluminum turbine blade with a composite turbine blade.


This paper studies the pragmatic identities of the spokesmen of Chinese Taiwan Affairs Office constructed in answering the reporters' questions by qualitatively analyzing the data from the Taiwan-related discourse in the year 2013. The results show that there are two major pragmatic identities constructed: one is the spokesman's professional identity,and the other is the spokesman's situated identity determined by the communicative needs and the contextual factors,including defenders of national sovereignty,cross-strait cocoordinator and facilitator. These three situated identities are primarily constructed through mode of discourse,pragmatic presupposition,speech acts and specific vocabulary choice. These findings suggest that discursive choices,identity construction and position constitute an integral whole.


America's #1 Customer Service Company. After the Gold Rush: A Store Is Born. The Next Generation: Perfecting "The Nordstrom Way". The Nordstrom Culture: Setting Employees Free. "What's Inside": Creating an Inviting Place. A Company of Entrepreneurs: The "Nordies" Versus the Clock--Punchers. The Art of Selling: Retailing Is a Contact Sport. Customer Service the Nordstrom Way: The Future. Index.


Processor speed has been improving faster than memory laten cy for over two decades. Thus, an increased portion of execution time is spent stalling on loads, waitin g for data from the memory hierarchy. Prefetching is an effective mechanism to hide memory latency for application s with low temporal locality. However, existing hardware prefetching techniques work well for array-based prog rams but not effective effective for pointer-intensive applications. Existing software prefetching techniques r quire recompilation or even modifications to application code before running on a new system with different hardware p ameters. In this paper, we exploit two opportunities to address this c hallenge. First, chip-multiprocessors (CMPs) are quickly becoming the norm, providing spare processors for p refetching tasks. Second, productivity reasons encourage programmers to make frequent use of standard or popu lar data-structure libraries. Hence, we propose a novel software prefetching scheme for pointer-based datastructures in which prefetching is performed by a helper thread included in the data-structure library code. The pre fetch thread runs on a spare processor and relies on the library's knowledge of the data-structure type and acce ss pattern to perform effective prefetching. All the development effort for prefetching is concentrated in the l ibrary code and is done once. The user application is not modified at all, as the library API remains the same. We imp le ent and evaluate the library-based prefetch scheme. We demonstrate that it performs accurate prefetchi ng and leads to an average reduction in execution time of 26% for pointer-intensive benchmarks with appreciable memor y stall time. Furthermore, we show that, using dynamic adaptation, the benefits from library-based prefet ching are robust across a range of memory system and application parameters without the need for recompilation .


Background
Astrocytes were important glial cells which played an crucial role in the energetic metabolism, signal transduction and electrical activities in neurons. The energetic metabolism of astrocytes after cerebral ischemia affected neurons' survival and brain function.

Objective
To explore a new treatment strategy for cerebral ischemia on the basis of energetic metabolism of astrocytes.

Content
This review article would focus on how energetic metabolism of astrocytes would change after ischemia and its possible mechanism and clinical significance.

Trend
Provide a new thought on the treatment of early cerebral ischemia.

Key words:
Cerebral ischemia; Astrocyte; Energetic metabolism


This thesis is engaged in a broader sense, considering the aging population and the problems of old age and aging in the narrower sense leisure activities namely social and cultural life of the elderly and their quality. The theoretical part starts with defining terminology and theoretical foundations of the chosen topic, including the definition of fundamental concepts and state of the subject in the domestic and foreign literature. Also taken pains to clarify and describe the relationship and the relationship to social pedagogy. Subsequently they are described and defined in terms of age and aging, its patterns, chronology, important changes which occur at him and demografiea sociology age. The next section focuses on the values, needs and motivation and free time alone seniors and possibilities activation. The practical part focuses on the research of socio - cultural life and the way of spending leisure casuseniorů in Zlin carve its potential differences in urban and rural areas. For its implementation was chosen quantitative approach in the form of data collection using the questionnaire.


Abstract This study assessed neonatal visual maturity in infants with congenital heart disease (CHD) and its predictive value for neurodevelopmental outcomes. Neonates with CHD underwent a standardized visual assessment before and after cardiopulmonary bypass surgery. Visual maturity was rated as normal versus abnormal by means of normative reference data. Twelve-month neurodevelopment was assessed with the Bayley-III. Twenty-five healthy controls served as the reference group. Neonatal visual assessment was performed in five neonates with CHD preoperatively and in 24 postoperatively. Only postoperative assessments were considered for further analysis. Median [IQR] age at assessment was 27.0 [21.5, 42.0] days of life in postoperative neonates with CHD and 24.0 [15.0, 32.0] in controls. Visual performance was within reference values in 87.5% in postoperative CHD versus 90.5% in healthy controls (p = 1.0). Visual maturity was not predictive of neurodevelopment at 12 months. These results demonstrate the limited feasibility and predictive value of neonatal visual assessments in CHD.


This analysis of data from the open‐label extension (OLE) phases of three randomized clinical trials of quetiapine in patients with schizophrenia (n=415) was undertaken to investigate whether the initial improvements in anxiety and depressive symptoms were maintained during long‐term treatment. The mean (95% confidence interval [CI]) change from the acute phase baseline in the Factor I score of the Brief Psychiatric Rating Scale (BPRS), which includes somatic concern, anxiety, guilt feelings, and depression, was calculated at the OLE baseline and at various time points up to 156 weeks. After 6 weeks of treatment with quetiapine during the acute phase, the mean (95% CI) change in the BPRS Factor I score was −1.13 (−1.23, −1.04) and after 156 weeks, it was −1.33 (−1.78, −0.87). Therefore, the efficacy of quetiapine for the treatment of anxiety and depressive symptoms is maintained in long‐term treatment. Depression and Anxiety 00:000–000, 2004. © 2004 Wiley‐Liss, Inc.


One of applications of sulfur in building industry is producing sulfur concrete (SC). High resistance, in acid environments, gaining high and rapid resistance, not using water during preparation, the possibility of recycling and low permeability can be pointed out as the most significant specifications of sulfur concrete .The present study investigates the role of acid on mechanical resistances including compressive and tensile strength on modified and none-modified sulfur concrete .The implications indicate that sulfur concretes are much more resistant against acids as compared with regular concretes .economically, It can be referred that if preparation of SC becomes more easier, it can replace regular concrete in a number of regular hydraulic projects.


This prospective, randomized, controlled study aimed to evaluate clinical and immunological effects of one year of SLIT. Eighteen atopic Beagles, sensitized to dust mites (DM), timothy grass (TG) and ragweed (RW) were randomly divided into control (n=6, vehicle) and active (n=12, 3 allergens) groups. Allergen challenge and scoring of clinical signs during challenge was done before and at the end of SLIT. Clinical signs (without challenge) were scored after 1, 2, 3, 4, 8 months and 2 months after stopping SLIT. Blood was drawn at baseline, 4, 8, and 12 months of SLIT and 2 months after stopping for allergen-specific IgE, IL-10, and TGF-beta. For clinical scores, ANOVA showed significant effect of time (end 80%, 1/6 61-80%, 2/6 41-60%; 2/6 21-40%, 0 80%, 1/12 61-80%, 7/12 41-60%, 2/12 21-40%, 0 40% was 50% in the control and 66% in the active group. For allergen-specific IgE a significant effect of time was found for DM (end beginning). For TGF-beta, significant effects of group (active > control) and time (end > beginning) were found for RW. For IL-10 a significantly effect of group (active > control) and time (end > beginning) was found for RW. Also for IL-10, a significant effect of time (end > beginning) and group x time interaction were found for TG.


This research is entitled "From Village to Destination: Developing Tourism Potential to Improve the Economy of Sambirejo Village". The goal is for tourism to become one of the economic drivers, so it is necessary to develop the tourism potential in Sambirejo Village. Based on the problems found in the field, there are still many outsiders who do not know the potential in Sambirejo Village. Therefore, it requires participation from all elements, both the community and the government. The method used in this research is a qualitative research method with a participatory approach. Data collection was carried out by interview, observation and FGD. In the preparation of this service, several steps have been taken including increasing public awareness through the socialization of one home one plant, building a mini garden, building a sign system as a boundary marker between hamlets, training in digitizing MSMEs through digital branding and product photos, and promoting in the form of a QR Code.


As the first steps on an intelligent speed adaptation (ISA) in Belgium are taken, the need for an accurate speed limit database is growing. Based on studies to reveal available speed limit information on higher and lower (municipalities) level, and taking into account European guidelines and standards, a dynamic speed limit database is being developed. Furthermore a framework is constructed for the distribution and updating of this speed limit database and for the provision of real-time speed information in vehicles (dynamic ISA). The research is part of the NextGenITS project that aims to implement several ITS services presented in an integrated demonstrator for Flanders.


An algorithm of coarse and fine interpolation applied to the CNC system has been come up with in this paper,where by time-cutting precise algorithm,coarse interpolation has been made and fine interpolation has been implemented using parameter cubic spline interpolation.


This paper proposes a novel single-phase quasi-Z-source AC/AC converter (qZSAC). Compared to traditional single-phase Z-source AC/AC converter, the proposed qZSAC has following features: the input voltage and output voltage is sharing the same ground; the operation is in continuous current mode (CCM). The proposed qZSAC can control to shape the input current to be sinusoidal and in phase with the input voltage. The operating principles, simulation results are presented. To verify these described performance features, PSIM simulation and experimental results were performed with a low total harmonic distortion of input current and high input power factor.


In this Special Issue on N-Heterocyclic Carbenes and Their Complexes in Catalysis, we report the first example of Suzuki–Miyaura cross-coupling of amides catalyzed by well-defined, air- and moisture-stable nickel/NHC (NHC = N-heterocyclic carbene) complexes. The selective amide bond N–C(O) activation is achieved by half-sandwich, cyclopentadienyl [CpNi(NHC)Cl] complexes. The following order of reactivity of NHC ligands has been found: IPr > IMes > IPaul ≈ IPr*. Both the neutral and the cationic complexes are efficient catalysts for the Suzuki–Miyaura cross-coupling of amides. Kinetic studies demonstrate that the reactions are complete in < 1 h at 80 °C. Complete selectivity for the cleavage of exocyclic N-acyl bond has been observed under the experimental conditions. Given the utility of nickel catalysis in activating unreactive bonds, we believe that well-defined and bench-stable [CpNi(NHC)Cl] complexes will find broad application in amide bond and related cross-couplings of bench-stable acyl-electrophiles.


Ten nonaphasic volunteers and 10 individuals with aphasia were assigned to dyads and videotaped in conversation. Judges ranked each volunteer in the videotaped conversations from 'best' to 'worst' communication partner. The two best and two worst interactions were submitted to detailed analysis using Conversation Analysis (CA) methodology. Discourse devices and resources employed by speaking partners in the dyads were identified. Results abstracted from the CA were compared to contrast discourse characteristics between the high ranked and low ranked partners. Specific strategies identified and implications for aphasia intervention are discussed.


We depict and discuss a key outcome of the first year of a large three-year Australian Research Council supported e-learning research and development project (DESCANT -- SciTech: Designing E-learning Systems to Celebrate and Nurture Teaching in Science and Technology). This collaboration with the New South Wales Department of Education and Training (DET) tests an innovative strategy for seeding a future-oriented, sustainable and effective professional development system for elementary school Science and Technology teachers. Initially, a group of teachers is designing and prototyping an e-learning environment to address teachers' professional development needs, as they see them, supported by their consultant, DET officers and University researchers. DESCANT culminates a long history of investigations of learning and teaching, exploring the educational potency of a generative theory of learning. Here, learning is conceived (after Edelman, 1992; Plotkin, 1994, 1997, 2002) as iterative cycles of generating ideas, testing them on their value and keeping those that survive the tests (Schaverien and Cosgrove, 1999, 2000). This view of learning plays out in DESCANT at many levels. Teachers play key roles as researchers and designers. Researchers use established anthropological and ethnographic approaches, notably research conversations, to construct a rich case study of an emergent strategy as it builds in scale.


Pacman is an arcade game where a group of "ghosts" try to catch a Pacman as he attempts to eat all the dots in a maze in order to progress to the next level. The standard Pacman game uses traditional AI search techniques for the ghosts and does not utilize the concept of machine learning. We propose to use an evolutionary computational method instead that implements a combination of genetic algorithms and neural networks in order to improve the level of play for the ghosts. We use a unique genetic structure for each ghost, a metric for determining the fittest ghosts of the current generation, and define parameters such as crossover probability and mutation percentage in order to create genetic offspring for the new population. Furthermore, we use a backprop neural network to optimize the crossover probability and mutation percentage values in order to minimize search time. The final test simulation successfully demonstrates the combined application of GA and NN in Pacman and its potential for machine learning in similar games.


Deep learning has achieved remarkable success in numerous computer vision tasks. However, recent research reveals that deep neural networks are vulnerable to natural perturbations from poor visibility conditions, limiting their practical applications. While several studies have focused on enhancing model robustness in poor visibility conditions through techniques such as image restoration, data augmentation, and unsupervised domain adaptation, these efforts are predominantly confined to specific scenarios and fail to address multiple poor visibility scenarios encountered in real-world settings. Furthermore, the valuable prior knowledge inherent in poor visibility images is seldom utilized to aid in resolving high-level computer vision tasks. In light of these challenges, we propose a novel deep learning paradigm designed to bolster the robustness of object recognition across diverse poor visibility scenes. By observing the prior information in diverse poor visibility scenes, we integrate a feature matching module based on this prior knowledge into our proposed learning paradigm, aiming to facilitate deep models in learning more robust generic features at shallow levels. Moreover, to further enhance the robustness of deep features, we employ an adversarial learning strategy based on mutual information. This strategy combines the feature matching module to extract task-specific representations from low visibility scenes in a more robust manner, thereby enhancing the robustness of object recognition. We evaluate our approach on self-constructed datasets containing diverse poor visibility scenes, including visual blur, fog, rain, snow, and low illuminance. Extensive experiments demonstrate that our proposed method yields significant improvements over existing solutions across various poor visibility conditions.


We present a detailed analysis of the two-point correlation function, xi(sigma, pi), from the 2dF Galaxy Redshift Survey (2dFGRS). The large size of the catalogue, which contains similar to220 000 redshifts, allows us to make high-precision measurements of various properties of the galaxy clustering pattern. The effective redshift at which our estimates are made is z(s) approximate to 0.15, and similarly the effective luminosity, L-s approximate to 1.4L*. We estimate the redshift-space correlation function, xi(s), from which we measure the redshift-space clustering length, s(o) = 6.82 +/- 0.28 h(-1) Mpc. We also estimate the projected correlation function, Xi(sigma), and the real-space correlation function, xi(r), which can be fit by a power law (r/r(o))(-gamma), with r(o) = 5.05 +/- 0.26 h(-1) Mpc, gamma(r) = 1.67 +/- 0.03. For r greater than or similar to 20 h(-1) Mpc, xi drops below a power law as, for instance, is expected in the popular Lambda cold dark matter model. The ratio of amplitudes of the real- and redshift-space correlation functions on scales of 8-30 h(-1) Mpc gives an estimate of the redshift-space distortion parameter beta. The quadrupole moment of xi(sigma, pi) on scales 30-40 h(-1) Mpc provides another estimate of beta. We also estimate the distribution function of pairwise peculiar velocities, f (nu), including rigorously the significant effect due to the infall velocities, and we find that the distribution is well fit by an exponential form. The accuracy of our xi(sigma, pi) measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of xi(r) and the two redshift-space distortion effects parametrized by beta and velocity dispersion, a. We find beta = 0.49 +/- 0.09 and a = 506 +/- 52 km s(-1), although the best-fitting values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(or), and find that the shape is consistent with models and simulations. This is the first time that beta and f (v) have been estimated from a self-consistent model of galaxy velocities. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that beta(L = L*, z = 0) = 0.47 +/- 0.08, and that the present-day matter density of the Universe, Omega(m) approximate to 0.3, consistent with other 2dFGRS estimates and independent analyses.


Sagnac effect enhancement can improve optical gyro precision. For a certain input intensity, we suggest that the other input port of beam splitter (BS) should be fed with some quantum light to break through shot noise limit (SNL) to improve Sagnac effect without increasing radiation-pressure noise (NRP). We design a Sagnac effect quantum enhancement criterion (SQEC) to judge whether some quantum light can enhance Sagnac effect and present a Sagnac effect enhancement scheme that utilizing Fock state light and parity measurement technique to extract the output phase. The results of the theoretical analysis show that the maximum sensitivity can be reached at θ = 0, and the phase precision can break through SNL and even achieve Heisenberg limit (HL). When the Fock state average photon number n is far less than coherent state, the minimum measurable angular rate is improved with 2n+1 times, which can deduce shot noise and increase NRP little.


Forest activity in rural properties of the region of Otacilio Costa SC, Brazil. The municipality of Otacilio Costa shows up in Santa Catarina State scenario because of its increasing participation in the forestry sector, which is evidenced by the enlargement of forest land area. In order to analyze interactions of such activity on rural property as on the region, this study aimed to collect data of the rural proprietors regarding to forestry activity, for evaluation of their knowledge towards forestry practice, as well as its importance, maintenance, adequacy, perceived benefits, and economic and environmental variables associated to rural property. The collected data is result of application forms used in interviews with rural producers in Otacilio Costa - SC, Brazil. Characteristics of proprietors and properties indicate a trend of land concentration. Forest producers, with little technical knowledge of forestry and lack of technical assistance, implant forests by their own, having as result a reforestation of low productivity and technology, which reduce the economic potential of the stands. In order to improve dissemination of technical knowledge and forest law it is necessary to develop public policies by relevant bodies and programs of companies, such as forest promotion and rural extension in the region


The Energetic Particle: Acceleration, Composition and Transport (EPACT) experiment for the WIND spacecraft to be launched in late 1992 is presented. This experiment is designed to study the acceleration, composition and transport of a wide variety of energetic particle populations, including particles accelerated in interplanetary shocks, particles from solar flares, the anomalous component, and the Galactic cosmic rays.


Lung cancer has become the main cause of harming to human health and leading to death.More than half of lung cancer occurred in the elderly patients,most of which are advanced stage while diagnosed.About the diagnosis and treatment of those patients,there are still some questions.For example,complicating several diseases that confuse the symptem of lung cancer result in delaying in diagnosis,away from oncology hospital because of fear,attach excessive importance to the durg but neglect the psychological factors of the patients,and so on.As a result,parts of the elderly patients with lung cancer can not be treated correctly and timely,which is worthy of provoking the clinician's attention.


BACKGROUND
Mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can cause congenital bilateral absence of vas deferens. Yet, the spectrum and frequency of CFTR mutations in Indian males with congenital absence of vas deferens (CAVD) is unknown.

METHODS
We investigated 50 Indian males, diagnosed with unilateral or bilateral absence of vas deferens at the PGIMER, Chandigarh, for the presence of the most common CFTR gene mutations as well as unknown mutations by single-strand conformation polymorphism followed by sequence analysis.

RESULTS
This study led to the identification of 12 CFTR gene mutations on 48% of 100 Indian CAVD chromosomes. CFTR mutations were identified on both alleles in 11 patients (22%) and on one allele in 26 patients (52%). Novel CFTR mutations identified were L69H, F87I, G126S, F157C, E543A, Y852F and D1270E. The T5 allele (25%) and F508del (11%) were the most common mutations identified. The most common intragenic marker haplotype for F508del was 2111 (GATT, TUB9, M470V and T854T). No mutations could be detected in 13 CAVD patients (26%), including 4 with renal malformations.

CONCLUSIONS
This study confirms the molecular heterogeneity of CFTR mutations in CAVD. Although the mutation detection rate is indeed lower in Indian CAVD patients, 74% of the patients tested had at least one CFTR mutation. CAVD alleles with no mutations suggest that other changes may be located at the non-screened sites that require extensive search by direct sequencing. Furthermore, the novel CFTR mutations identified require functional studies in a cell-based system.


Based on monlinear coming model, this article builtds an adjusted model,compared adjusted model error with original model's,and then presents the actual predicted formula and cases.


Summary Observations were conducted on samples from various parts of the digestive tract of cattle for the presence of four types of bacteria characteristically present in rumen samples from cattle. Evidence was being sought regarding the availability of bacterial products to the host. The first of the four organisms were larger coccoids. Some of them were observed in all parts of the digestive tract, although sometimes apparently in less concentration in the more posterior parts of the large intestine. The second, which were large cigar-shaped organisms, disappeared in the abomasum and were missing in the remainder of the tract. On addition to samples of the contents of the abomasum and small intestines, they were destroyed but not so by those samples from the large intestine. The third type was composed of small rods which formed in flat rectangular groups. These appeared to disintegrate gradually as they reached the posterior parts of the tract, although some were observed in samples from the caecum and colon. The same apparently was true of the bacteria of the fourth group, which were thick square-ended rods. The destruction of protozoa by abomasal fluids, reported by others, was confirmed in this study. It is concluded from the data, although somewhat limited, that the ultimate fate of rumen microorganisms varies between the extremes of complete destruction in the abomasum to passage entirely through the digestive tract of the host.


Evolution Lab is a software engineering MEng. project that allows complex robot designs to be simulated in a real world environment. Evolution Lab was created as a research tool. The system is extendible and embeddable so that it can be customized for use in a wide area of robotic problem domains. It has also been engineered to be user friendly so that its standard features are quickly available to the user without the need of extensive documentation. Included with Evolution Lab is an evolutionary computing library, this allows the system to be used in the evolutionary robotics domain.


A box (21) optical fiber for housing optical fiber connections comprising: a housing (23) a set (25) of wire coil disposed on an outer surface of the housing, having the decoiled wire bundle a first side cutout (55a) and a second cut-out side (55b), where recortablesprimero and second sides include at least one cutting line (85) extending from an inner diameter of conjuntode wire coil to an outer diameter of the coil assembly of cable; yuna plate (27) assembly fixed for rotation to the wire coil assembly so that the decoiled wire assembly and the housing rotate selectively and jointly about an axis of the mounting plate.


Purpose – This paper aims to explore some of the strategies and issues associated with writing historical research to meet the demand for social "relevance" and to appeal, and be accessible to, a broader audience of readers.Design/methodology/approach – The paper uses Brown and Hackley as a foil for identifying the key differences between traditional academic writing and writing to get noticed. These differences are then analyzed to identify the issues for academic historians.Findings – The paper highlights distinct uses of rhetoric, metaphor and theory in Brown and Hackley that make their paper stand out from typical academic history papers and raises concerns about this style of research and writing.Originality/value – The paper identifies and opens the debate on some key issues in historical writing and explanation that arise when academic historians take seriously the demand to seek greater contemporary relevance and public support for their research.


There is an abundance of circumstantial evidence to suggest that a cartel existed among LIBOR panel banks. Lianne Craig, Rodger Burnett, & Gurpreet Chhokar (Hausfeld & Co LLP)


Telecommunications power stations must satisfy harsh maintainability availability and operating constraints. The French PTT Administration and its associated industrialists propose : "A new material and data processing design for high availability target: The GEODE System". Operating safety is guaranteed by special architecture of the a.c. source composed of a generating set operating in sequential redundancy with the public mains network, a micro-data processing monitoring and control system linked by a specialized highway network to a central management unit common to the telecommunications systems of a whole region. The authors demonstrate their theoretical approach that has made it possible to attain the goal of operational safety by means of the Markov Chain and the Fault Free Analysis models and also their experimental approach in the organization of secondary circuits and sensors associated with the generating set. The last part of the paper is devoted to the description of the different functions of the software introduced into the monitoring and control units as also into the centralized management system (alarms, log book, periodic tests, curative or corrective maintenance, operational procedures, modifications to configurations). Apart from its design and its operation non-specific to telecommunications, the GEODE system introduces numerous innovations which can be extended to other equipment requiring high operating safety and operating facilities ensured by remote management and a powerful aid to troubleshooting.


Because of the potential deleterious effects of impurities in water and steam, the current sampling and analytical practices are being critically evaluated, and methods and utilization of analytical data are being improved. To control the corrosion and efficiency loss, particularly in turbines, once-through boilers, reactors, and nuclear steam generators, low parts-per-billion levels of impurities are being sampled and analyzed. The critical areas reviewed are sampling, grab sample, continuous, and in situ analysis; analysis organics; and utilization of the data for system control and corrosion prediction. Certain improvements and refinements in all these areas are discussed. 8 refs.


The development and progression of diffuse pigmentation and venous ectasia on the dorsa of the hands of a healthy middle-aged man were closely studied clinically and histologically for 21/2 years. Associated were bilateral edema of the hands, an increase in the number and size of cutaneous blood vessels, as well as a progressive increase of iron pigment in the skin of the dermis. It is proposed that these findings are an expression of a venous stasis syndrome.


A new technology of refining soda-calcium-silicon glassy surfaces with aluminium compounds nano-molecules has been shown in the present study. A structural definition of aluminium compounds nano-powders exposed to thermal processing, including grain-size analysis, has been discussed. Optimal technical and technological parameters of the refining process have been selected. The method of refining soda-calcium-silicon glassy surfaces with aluminium compounds nano-molecules ensures profitable operational properties of the glass, such as increased bending strength, scratching resistance, micro-hardness and chemical resistance without deterioration of the optical properties. Nano-molecules were spread onto the heated glass surface, or onto the cold glass surface and then heated up to temperatures close to the glass transformation, when nano-molecules penetrate into the glass surface. Testing results of the glass operational properties, such as bending strength, scratching resistance, micro-hardness, chemical resistance and optical properties have been presented. The received results develop new possibilities with respect to opaque glass, float glass and glass fibres, as well as to glass processing.


A model of the bar and old stellar disk of the Galaxy has been derived from the survey of the Diffuse Infrared Background Experiment (DIRBE) of the Cosmic Background Explorer at wavelengths of 1.25, 2.2, 3.5, and 4.9 microns. It agrees very well with the data, except in directions in which the near- infrared optical depth is high. Among the conclusions drawn from the model: The Sun is located approximately 16.5 pc above the midpoint of the Galactic plane. The disk has an outer edge four kpc from the Sun, and is warped like the HI layer. It has a central hole roughly the diameter of the inner edge of the "three-kiloparsec" molecular cloud ring, and within that hole lies a bright, strong, "early-type" bar, tilted approximately 14 degrees from the Sun-Galactic center line. The model has 47 free parameters. The model is discussed in detail and contour plots and images of the residuals presented.


Conditions for a self-organized formation of ordered hexagonal structure in anodic alumina were investigated, using oxalic or sulphuric acid as an electrolyte. Highly-ordered nanopore arrays with pore densities of 9×109-6.5×1010cm-2 and high aspect ratios over 3000 were fabricated by a two-step anodization process. The array exhibits characteristics analogous to a two-dimensional polycrystalline structure of a few micrometres in size. The interpore distance can be controlled by changing the electrolyte and/or the applied voltage. The formation mechanism of ordered arrays is consistent with a previously proposed mechanical stress model, i.e., the repulsive forces between neighbouring pores at the metal/oxide interface promote the formation of hexagonally ordered pores during the oxidation process.


The promising energy saving and QoS gains of Predictive Resource Allocation (PRA) techniques have recently been recognized in the wireless network research community. These gains were primarily introduced in light of perfect prediction of both mobility traces and anticipated channel rates. However, under real world considerations of prediction errors, the reported gains cannot be guaranteed and further investigation is needed. In this paper, we demonstrate the practical potential of PRA by developing a robust, probabilistic framework that guarantees QoS satisfaction for video streaming under imperfect predictions, without compromising the energy saving gains. The proposed PRA framework uses chance-constrained programming to model video streaming QoS for all users during the foreseen time horizon. Closed form solutions are developed using the Gaussian and Bernstein approximations based on the channel statistical measures. Extensive numerical simulations using a standard compliant Long Term Evolution (LTE) system are presented to examine the developed solutions, for different user mobility scenarios and target QoS levels. The results demonstrate the various design trade-offs involved toward the practical deployment of predictive video streaming in future generation networks.


This paper researches qualitative and quantitative transformation model-cloud model in uncertain artificial intelligence in order to solve uncertain questions which exist in image segmentation.We propose a new approach for image segmentation based on the cloud model.This method adopts the interactive way to choice training site,produce cloud models using pixels in the training site.Finally we produce a Pan-Concept-Tree with Pan-Concept-Tree Generation algorithm,and realize image segmentation with maximum likelihood principle.This method is more effective to express uncertainty in image.Several group of experiments show that this method can segment goals in image exactly,and more effectively than traditional image segmentation algorithm.


A novel Azo-Schiff base ligand L 2-[1.5-Dimethy l-3-[2-(5-methyl-1H-indol3-yl) - ethylimino] - 2 - phenyl - 2,3 - dihydro - 1H - pyrazol - 4 - ylazo] - 5hydroxy -benzoic acid has been synthesized from reaction 1.5-Dimethyl-3-[2-(5methyl- 1 H - indol - 3 - yl) - ethylimino] - 2 - phenyl - 2.3 - dihydro - 1H pyrazol - 4 - ylamine (A) with m-hydroxy benzoic acid. Then, its Zn(II), Cd(II) and Hg(II) complexes were synthesized with the general formula [ML1Cl] where M = Zn(II), Cd(II) and Hg(II) are reported. The ligand and its metal complexes have been characterized by elemental analysis, metal content, Chloride containing, molar conductance, FT-IR, 1 H and 13 C- NMR, UV-Vis spectra, magnetic susceptibility, thermal analysis, and mass spectra. The activation thermodynamic parameters, such as ΔE * , ΔH * , ΔS * ΔG * and K are calculated from the TGA curve using Coats-Red fern method. The all prepared complexes were assayed for antibacterial (Escherichia coli and Staphylococcus aureus) activities by disc diffusion method. The results indicate that all tested ligand and complexes show antibacterial activity against E. coli and S aureus, as gram negative and positive bacteria.


The segmentation problem can be viewed as a learning and merging problem based on superpixels (image segments), which can incorporate a group of cues to guide the segmentation. So the proposed multi-label segmentation algorithm mainly consists of two stages: the learning stage and the merging stage. In the learning stage, Gaussian Mixture Models (GMMs) firstly learn color models for different components of objects. Based on the likelihood, we execute the alpha-expansion algorithm only once in order to alleviate the shrinking bias. The initial labels help determine whether a superpixel is too noisy, and the contour responses between superpixels can distinguish spurious boundaries. Those superpixels containing too much noisy pixels and spurious boundaries will be unlabeled. In the merging stage, unlabeled superpixels may have similar color information while differing in texture information. Therefore, they can be correctly classified by a novel region merging algorithm based on maximal similarity. In this way the advantages of features in different levels are enhanced by uniting them in different stages. Finally, the proposed method is evaluated on the Berkeley segmentation benchmark, the Graz benchmark and the Grabcut benchmark. Experimental results show that our method obtains the highest accuracy on the Graz benchmark, and the performance on other benchmarks can also be comparable or better than current leading algorithms.


Black rice is well known as healthy food. Nowadays, some people try to change their diet with this rice. However, it still has a problem with long preparation time and hard texture. Parboiling is a hydrothermal process that changes rice starch from crystalline to amorphous. The parboiling process of rice consists of soaking in sodium citrate solution, high-pressure cooking, freezing-thawing and drying. The aim of this research was to find the optimum condition from three processing variables: concentration of sodium citrate (0, 2, 5 and 5%, w/v), cooking period in an autoclave (5, 10 and 15 min) and a number of freeze-thaw cycles (1, 2.5 and 4). The optimum condition was achieved with 3.8% sodium citrate concentration, 5 min cooking in an autoclave, and 3.8 freeze-thaw cycles. This optimum condition resulted in parboiled black rice with 25.84 min cooking time, 4.93 total colour difference 101.80 N hardness of cooked rice, 49.04 N chewiness of cooked rice, 5.32 kg rice grain hardness.


This paper introduces the psychological state of the librarians in the age of compound library, and puts forward some corresponding suggestions.


Cultural competence requires more than the accumulation of information about cultural groups. An awareness of the nurse's own culture, beliefs, and values is considered by several transcultural nursing theorists to be essential to the development of cultural competence and the provision of quality patient care. Using Transformational Learning Theory, this article describes event analysis, an active learning tool that uses the nurse's own practice to explore multiple perspectives of an experience, with the goal of transforming the nurse's approach to diversity from an ethnocentric stance, to one of tolerance and consideration for the patient's needs, values, and beliefs with regard to quality of care. Furthermore, the application of the event analysis to multiple settings, including inpatient, educational, and administrative environments, is discussed.


We present a scheme for generating first-order metric perturbation initial data for an arbitrary background and source. We then apply this scheme to derive metric perturbations in order-reduced dynamical Chern–Simons gravity (dCS). In particular, we solve for metric perturbations on a black hole background that are sourced by a first-order dCS scalar field. This gives us the leading-order metric perturbation to the spacetime in dCS gravity. We then use these solutions to compute black hole shadows in the linearly perturbed spacetime by evolving null geodesics. We present a novel scheme to decompose the shape of the shadow into multipoles parametrized by the spin of the background black hole and the perturbation parameter . We find that we can differentiate the presence of a pure Kerr spacetime from a spacetime with a dCS perturbation using the shadow, allowing in part for a null-hypothesis test of general relativity. We then consider these results in the context of the event horizon telescope.


In our work we have conducted researches intact and cariosity process of enamel and dentin of human tooth using by FTIRspectra-microscopy with use synchrotron radiations. It is shown that enamel caries is characterised by growth of deformation and valence vibrations N-C-O, N-H and C=O that speaks about destructive processes in organic matrix of hydroxyapatite. As a result subsurface demineralization also the crystal of enamel and dentin further collapses.


Diffuse large B-cell lymphomas (DLBL) are the most common type of non-Hodgkin's lymphoma (NHL), account for 30% to 40% of NHL. Treatment with conventional combination chemotherapy produces complete remission rates of 50 to 70%. Target therapy such as anti-CD20 monoclonal antibody (rituximab) had shown favourable results. In recent years, specific adoptive immunotherapy with tumor-specific T-cells was considered as a new and promising treatment in malignancy. Thereby, researches are focused mainly on the generation of effective antigen specific T-cells, both autologous and allogeneic specific T cells. The antigen specific T cells could be determined by analysis of the T-cell receptor (TCR) Vα or Vβ repertoire, which display monoclonal or oligoclonal expansion. In order to develop the specific cellular immunotherapy in DLBL, in the present study, we analysis at first the distribution and clonality of TCR Vβ repertoire in peripheral blood T cells by RT-PCR and genescan technique, which was expected to define the DLBL associated TCR Vβ subfamily T cells. 6 cases with DLBL were used in the study. The skew distribution and clonal expansion of TCR Vβ subfamily T cells could be found in all patients with DLBL. Monoclonal expanded T cells were identified in 3 cases, which used the Vβ3 (1 case) and Vβ13 (2 cases) subfamilies, the PCR products from the monoclonal T cells were analyzed by direct sequencing to define CDR3 sequence. The CDR3 sequences from these 3 TCRβ genes were identified, which were not identical in the reported TCR sequences in Genebank. The whole sequences of Vβ3 and Vβ13 found in 3 patients with DLBL were amplified and cloned, which are being registered in NCBI Genebank. These specific TCR Vβ genes will be farther used for research on generation of CTL by TCR gene-modified technique, and so on. In the clinical observation showed that patients who had specific reactive T cell clones had a preferable prognosis, suggesting that these detectable clonal expanded T cells might play a crucial role in tumor eradication.


Raman intensities are calculated for the torsional vibrations of methylcyclopropane and propylene oxide using an anisotropic atom‐point dipole interaction model to calculate the elements of the molecular polarizability tensor. It is predicted that electrical anharmonicity contributes substantially to the intensities of both the Δv = 1 and δv = 2 transitions. The calculated intensity distribution of the Δv = 1 transitions of propylene oxide is in excellent agreement with experiment. The calculated intensities of the fundamental transitions of methylcyclopropane are not in as good agreement with experiment as those of propylene oxide; however, the observed transitions of the former molecule are extremely broad and difficult to measure accurately. The calculations predict that the Δv = 1 transitions of both molecules are substantially more intense than the Δv = 2 overtones. The intensity of the overtones cannot be measured accurately because they are partially obscured by intense in‐dand out‐of‐plane bending...


Hogback Ridge field, discovered by American Quasar Co., is to date the only oil or gas field in the Idaho- Utah-Wyoming thrust belt not located on the Absaroka thrust plate. The field discovery, the No. 20-1 Hogback ridge, was completed on Oct. 11, 1977, for an initial potential (flowing) of 22,400,000 cu ft of sweet gas per day from the gross perforated interval 9,468 to 9,630 ft. Production, which began in Aug. 1978, was initially from fractured carbonates of the Triassic Dinwoody Formation. The producing structure is a tightly folded anticline on the hanging wall of an intraplate thrust of the Crawford thrust plate. The Permian Phosphoria Formation had been shut in after having flowed slightly sour gas during production testing at the rate of 9,900,000 cfd from the gross perforated interval 10,070 to 10,224 ft. Finally, future exploration on the Crawford plate should include the Mississippian Mission Canyon Formation of the Madison Group as a primary objective, and must take into account structural discordances between shallow and deep features which are separated by decollements. 14 references.


One of the assessments of the dominant position of a business actor can be conducted based on the affiliation relationship of the business actor with other business actors, where the affiliation relationship regulated in Law of the Republic of Indonesia Number 5 Year 1999 on the Prohibition of Monopolistic Practices and Unfair Business Competition is concurrent positions and cross-shareholdings. Concurrent positions are prohibited when a person holds positions as directors or board of commissioners in two or more companies at the same time, where the companies are in the same relevant market, have close links in the type and/or field of business, or together can control the market share of certain services and/or goods. Legal issues regarding the concurrent position of members of the board of commissioners of BUMN arose during the enactment of Permen-BUMN PER-10/MBU/10/2020, which allows members of the board of commissioners of BUMN to hold concurrent positions under certain conditions. This is normative legal research that examines the prohibition of concurrent positions of BUMN commissioners in terms of business competition law in Indonesia.


When all electronic devices can be deprogrammed according to the requested function. The interests of the appropriate command of the human side need to be revealed, including the use of the local language. Waterwheels that mechanically work in each pond, for example, require automatic control to function efficiently, and this requires adjustment to the environment in which the appliance works, including adjusting the use of Natural Language Processing to assign tasks to the wheel. This paper will briefly describe the use of Jawa language to control the tool.


Replicative DNA polymerases are multiprotein machines that are tethered to DNA during chain extension by sliding clamp proteins. The clamps are designed to encircle DNA completely, and they are manipulated rapidly onto DNA by the ATP‐dependent activity of a clamp loader. We outline the detailed mechanism of γ complex, a five‐protein clamp loader that is part of the Escherichia coli replicase, DNA polymerase III holoenzyme. The γ complex uses ATP to open the β clamp and assemble it onto DNA. Surprisingly, ATP is not needed for γ complex to crack open the β clamp. The function of ATP is to regulate the activity of one subunit, δ, which opens the clamp simply by binding to it. The δ′ subunit acts as a modulator of the interaction between δ and β. On binding ATP, the γ complex is activated such that the δ′ subunit permits δ to bind β and crack open the ring at one interface. The clamp loader–open clamp protein complex is now ready for an encounter with primed DNA to complete assembly of the clamp around DNA. Interaction with DNA stimulates ATP hydrolysis which ejects the γ complex from DNA, leaving the ring to close around the duplex.


Objective:To investigate the application efficiency of clinical nursing pathways in percutaneous coronary intervention.Methods:one hundred and seven patients with an intention for PCI were randomly divided into observation group and control group,56 patients in observation group were given clinical nursing pathways,in addition,51 patients in control group were given routine nursing.Results:After percutaneous coronary intervention,psychological anxiety and arrhythmia in observation group were lower than that of control group(P0.05).While nursing quality and patients' satisfaction in observation group were higher than that of control group(P0.05).Conclusion:As a quality and scientific management mode for single disease,clinical nursing pathway can improve nursing quality and satisfaction degree of patients.


Experiments based on oscillatory motion are an essential part of the curricula for students of physics and engineering in their undergraduate studies, such as the determination of spring constant for a well-known classical oscillator i.e., spring-mass system. Moreover, it is important for students to understand the physics of damped oscillators because, in real-world scenarios, a system involving oscillations cannot be completely analysed without understanding conditions of damped oscillations i.e., underdamped, overdamped, and critical damped. In this work, we design a computational physics lab for the simulation of the underdamped oscillator using an Excel spreadsheet by employing 4th order Runge–Kutta method. Further, we construct a simple experimental setup to observe the damped oscillation and obtaindata for the underdamped system. Final analysis was based on comparison between the experimental data and the numerically estimated data.


The incidence of segmental testicular infarction (STI) is very low. Such a disorder most often affects young men. The most common symptom is sudden testicular pain. We report 6 cases of men diagnosed with STI. Clinical examination, blood test, urine analysis, and ultrasound examination with colour Doppler were performed. Furthermore, tissue sonoelastography or MRI was performed in selected patients. All men underwent surgical exploration. In all but one man, the affected testis was preserved. Although STI is a rare condition, it should be taken into account if testicular pain prior to suspicious ultrasound imaging occurs. To be aware of this benign testicular pathology and its clinical and imaging features is important to avoid unnecessary orchiectomies in young patients.


In this work, we report on the fabrication as well as on the structural and optoelectronical characterisation of ultra-thin In-rich InxGa1–xN (0.56 < x < 1) metal-semiconductor-metal photodetectors designed for standing wave intensity profile measurements at the wavelength of He-Ne laser. In particular, In0.64Ga0.36N/GaN structures have shown a short time response close to the RC time constant of ∼0.6 μs at low fields, with transparency of more than 77%. Structural analysis of InB0.64BGaB0.36BN layer showed no phase separation phenomena. However, a large biaxial strain and a gradient in the In content along the c-axis have been observed driven by enormous biaxial strain in the heterostructure. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)


The paper analyzes the role of football clubs in the process of local identity formation in the age of globalization. The empirical base is drawn from the data collected during the fieldwork research conducted among the fans of the Dutch football club Twente Enschede. Twente is deeply rooted in the tradition of the city and the region, and at the same time involved in European international competition and global football transfer market, being exposed to pressures stemming from growing commercialization and multiculturalism in the world of football. The consequences of these processes for the local fans and local community are discussed in the article.


On June 22, 2015, the US Food and Drug Administration (FDA) approved an expanded indication for perampanel hydrate (Fycompa; Eisai), an oral antiepileptic drug. This new indication allows the use of perampanel hydrate as an adjunctive treatment for primary generalized tonic-clonic (PGTC) seizures in patients with epilepsy aged ≥12 years.1 The FDA approval was based on new data from a phase 3 clinical trial showing a significant reduction in the frequency of PGTC seizures and freedom from seizures with perampanel hydrate versus placebo.1–3


The decomposition reaction kinetics of gun propellant TG0604 was investigated by non-isothermal method with TG-DTG under atmospheric pressure and ambulatory atmosphere conditions.The results show that there are two reaction stages in the decomposition process of gun propellant TG0604.The decomposition reaction mechanism of stage I obeys Mample single-file law with n=1,the kinetic parameters are obtained as: Ea=79.09kJ·mol-1,A=107.40s-1,and the kinetic equations can be expressed as:dα/dt=107.40(1-α)e-0.95×104/T;The decomposition reaction mechanism of stage II obeys three-step chemical reaction rule,the kinetic parameters are obtained as: Ea=214.79kJ·mol-1,A=1021.49s-1 and the kinetic equations can be expressed as:dα/dt=1021.19(1-α)3e-2.58×104/T.The critical temperatures of thermal explosion of gun propellant TG0604 obtained from the onset temperature(Te) and the peak temperature(Tp) are: Tbe=461.51K,Tbp=478.17K.ΔS≠,ΔH≠ and ΔG≠ of the two stages are calculated as: for stage I,-86.70J·mol-1·K-1,80.54kJ·mol-1 and 417.98kJ·mol-1;for stage II,214.78J·mol-1·K-1,236.95kJ·mol-1 and 136.07kJ·mol-1.


Some disperse dyes based on 2-amino-5-mercapto-1,3,4-thiadiazole have been prepared by coupling with various N-arylacrylamides. The dyes were characterized by IR spectral studies and elemental analysis. All the dyes were applied as disperse dyes on nylon fabric. These dyes have been found to give a wide range of color shades with very good depth and levelness on fabrics. The percentage dye bath exhaustion and fixation on the fabric have been found to be very good. The dyied fabrics showed moderate to good light fastness and very good to excellent washing, rubbing, persperation and sublimation fastness properties.


Using a second-harmonic (SH) scanning near-field optical microscope (SNOM) working in transmission with an uncoated fiber tip, we obtain highly detailed fundamental harmonic (FH) and SH images of a ∼50-nm-thick gold film deposited on a glass substrate and containing a ∼830-nm-period array of slightly elongated holes (diameters in perpendicular directions are ∼170 and 260 nm). The FH and SH images for three excitation wavelengths (730, 800, and 870 nm) are presented for different polarization combinations of the FH-incident and FH- and SH-detected radiations. It is seen that the symmetry of the FH images is primarily determined by the symmetry of surface plasmon polaritons (SPPs) excited (at the FH wavelength) at the gold-air interface, whereas the symmetry of the SH images is mainly governed by the symmetry of holes. We notice large differences in the strength of SH signals originating at different (nominally identical) holes and relate this feature to interference in the developed multiple scattering of SPPs.


of an Essay on the Origin of Species and Varieties Through Natural Selection", only his editor, John Murray, convinced Darwin to adopt the catchier title. (cf. Freeman 1977) 469 This does not imply that they grasped the difference between Chambers' and Darwin's models. By some commentators Darwin was accused of having taken his ideas from Chambers' Vestiges. (Schwartz 1990: 138) 470 Julia Voss emphasizes how well-known both images of evolutionary series and of Darwin must have been for such a caricature to work in a popular magazine. (Voss 2007: 11-2) Janet Browne provides an overview on the topic of caricatures in the Darwinian debate. (Browne 2001) For a look at the caricatures just search "caricature Darwin ape" in an online image repository, e.g. Google images. Sebastian Zacharias: The Darwinian Revolution as a knowledge reorganization 227 i. Ontological criticism: Divine Providence and Design First, critics dismissed the agnostic tendencies and aimed at amending Darwin's narrative with elements of Victorian theism. Darwin found defenders like the economist Henry Fawcett who claimed that the theory did not lessen the glory of God: "Those who, like Mr. Darwin, endeavour to explain the laws which regulate the succession of life, do not seek to detract one iota from the attributes of a Supreme Intelligence. Religious veneration will not be diminished, if, after life has been once placed upon this planet by the will of the Creator, finite man is able to discover laws so simple that we can understand the agency by which all that lives around us has been generated from those forms in which life first dawned upon this globe." (Fawcett 1860: 283) However, while most supporters of Darwin avoided teleological topics – often claiming they assessed the theory on scientific grounds only – most public critics aimed precisely at these perceived ontological implication of Darwin's theory. In Fraser's Magazine, the mathematician William Hopkins blamed Darwin for "the adoption of pantheistic views, and the utter rejection of the doctrine of final causes, and of the belief in a Supreme Intelligence and personal Governor of the universe. " (Hopkins 1860: 741) Sedgwick, in the Spectator, stopped just inches short of accusing Darwin of atheism which, at the time, would have been a strong public defamation: "A cold atheistical materialism is the tendency of the so-called material philosophy of the present day. Not that I believe that Darwin is an atheist; though I cannot but regard his materialism as atheistical; because it ignores all rational conception of a final cause. " (Sedgwick 1973 [1860]: 161) Living Age called Darwin out for taking good care "not to attribute any intention to the Almighty" and for ignoring "all the facts which have appeared to most minds so significant of unity of plan, and thereby declarative of the unity of the Creator" and condemned the biologist's intrusion into the domain of theology. (Anonymous 1860b: 475-6) Moreover, both Sedgwick and Living Age offered an alternative ontology to Darwin's, one that could be perceived as proving God's existence and revealing his purpose (Hull 1973: 57) and preserved natural harmony: "Species have been constant for thousands of years; and time (so far as I see my way) though multiplied by millions and billions would never change them, so long as the conditions remained constant. Change the conditions, and old species would disappear; and new species might have room to come in and flourish. But how, and 471 The term 'agnostic' was termed by Huxley. 472 Indeed, opponents of the Darwinian theory often chose to address ontological issues while his supporters usually withheld from addressing these issues, often claiming that they wanted to assess the theory on scientific grounds only. 473 See (Hull 1973: 55-66) for a close discussion of the two main forms of teleology. Sebastian Zacharias: The Darwinian Revolution as a knowledge reorganization 228 by what causation? I say by creation. But, what do I mean by creation? I reply, the operation of a power quite beyond the powers of a pigeon-fancier, a cross-breeder, or hybridizer; a power I cannot imitate or comprehend; but in which I can believe, by a legitimate conclusion of sound reason drawn from the laws and harmonies of Nature. For I can see in all around me a design and purpose, and a mutual adaptation of parts which I can comprehend,-and which prove that there is exterior to, and above, the mere phenomena of Nature a great prescient and designing cause. Believing this, I have no difficulty in the repetition of new species during successive epochs in the history of the earth. But Darwin would say I am introducing a miracle by the supposition. In one sense, I am; in another, I am not. The hypothesis does not suspend or interrupt an established law of Nature. It does suppose the introduction of a new phenomenon unaccounted for by the operation of any known law of Nature; and it appeals to a power above established laws, and yet acting in harmony and conformity with them." (Sedgwick 1973 [1860]: 161) "Now these countless differences which distinguish all living forms from each other, ..., are yet just as much a part of creation — a part, so to speak, of the Divine plan — as the general laws themselves which underlie them, and which alone come within the scope and power of human science. Admitting, for the nonce, that law and order can be ascribed to the blind action of secondary or mechanical causes, these endless diversities still remain inexplicable except upon the supposition of the constant action of a free personal cause. [...]thus, indeed, 'we can perceive that events are brought about, not by insulated interpositions of Divine power,' but by exertions of it so frequent and beneficent, that we come to regard them as the ordinary action of Him who laid the foundations of the earth, and without whom not a sparrow falleth to the ground." (Anonymous 1860b: 505-6) This, alternative, however, was incompatible with Darwin's explanation, a process which lacked a teleologicaIly acceptable power and a definite direction for evolution. An important part of the public criticism aimed precisely at filling these perceived holes in Darwin's narrative; technically speaking, Darwin's critics aimed at providing a new Agent and a Purpose. (Ellegård 1958: 102, 128-140, 150) This line of criticism probably culminated in the Duke of Argyll's interventions in the mid-sixties. In The Reign of Law, he claimed that Darwin had not given any explanation "of the method in which Vital Forces are made to evolve a new Form of Life. But even if such explanation could be given, it would render no account at all of the fittings of that Form into the outward requirements of its life. These are Correlations which in their very nature belong to Mind, are the work of Mind, and are intelligible only in the light of Mind." (Argyll 1872 [1867]:261) To Argyll and the majority of Darwin's opponents, there was no difference between the supernatural and the natural, both being the workings of the "Reign of Law". Therefore, they wished to interpret evolution as a product of Divine law and required amendments to the model of Natural Selection – or they would not accept it as an explanation of Evolution. (Lynch 2001: xiii) To them, there was at least a "residuum of change" in Evolution not explicable by Natural Selection alone and this residuum Sebastian Zacharias: The Darwinian Revolution as a knowledge reorganization 229 opened the door for Design and Divine Providence. A comment in the 1871 Guardian's put this very clearly: "This amounts, as it seems to us, to a confession that Natural Selection may, after all, play only a secondary part in the differentiation of species, – that there may be behind and above it an 'unknown agency: giving the first impulses in certain definite directions which natural selection cannot alter ... It is a vast concession, and one which seems to us to cover all that [we] need ask for; since it is obvious that we may assign this 'unknown agency' to any cause ... and if we assign it to the finger of God, it will amount to a perpetual divine superintendence of the physical development of the world." (op. cit. Ellegård 1958: 130, cf. 274) ii. Ontological Implications: Position of Man On the descent of Man, opposition was equally strong. Anatomical similarities between Man and the higher apes were often admitted; for instance, Argyll admits that "the close and mysterious relations between the mere animal frame of Man, and that of the lower animals, does render the idea of a common relationship by descent at least conceivable. " (Argyll 1872 [1867]: 29) However, according to most critics, the human mind, soul and reason put Man apart from all other organic beings and in a class of his own. (Ellegård 1958: 311-329, Hull 2005: 149) These qualities in Man could not stem from some incipient form in animals; they must have been added independently from an outside force. "... we cannot speculate on man's position in the actual world of nature, on his destinies, or on his origin, while we keep his highest faculties out of our sight. Strip him of these faculties, and he becomes entirely bestial; and he may well be (under such a false and narrow view) nothing better than the natural progeny of a beast, which has to live, to beget its likeness, and then die for ever." (Sedgwick 1973 [1860]: 164) The question of morality implied social and political consequences for the social order of the time was erected upon religious truths. (Ellegård 1958: 322-5) Shattering these truths meant, in the eyes of many, shattering the fundament of the social order. (Desmond and Moore 1995: 655) Thus, rejection of the Darwinian theory frequently went hand in hand with a warning of its possible negative effect on the British society, if not the entire civilized world. As Sedgwick put it in the Spectator: 474 For radical Darwinians, the difference between man and ani


As CEO turnover occurs, the company may select an insider or outsider as a successor. This study attempts to ascertain whether firm performance, female directors, board religiosity and blockholder ownership influence the decision to appoint an internal or external candidate. Results from logistic regression analysis on 72 succession events over a five-year period (2011 to 2015) reveal that firms which are controlled by blockholders and those with females on their boards tend to select an outsider as the successor. Meanwhile, firms that have Muslims on their boards are more likely to select insiders as successors. This study implies that poor firm performance does not necessarily lead to outside CEO selection choice. On the overall, the findings indicate that blockholder ownership and gender diversity in the boardroom matter in the Nigerian corporate landscape.


A VM-based disaggregated cloud memory platform (DCM) virtualizes the memory device of a remote server connected to a highspeed network as an expansion of local memory. DCM provides large memory to applications to increase throughput. However, DCM is not well-suited to managing fair memory usage between processes when they run concurrently in a VM. This is because DCM has no mechanism to provide independent memory space to each process. As a result, DCM does not guarantee fairness and performance to processes. Partitioning memory for each process is a way to solve this problem. However, in DCM, the host kernel running DCM cannot obtain the memory page information of a process (including memory page address and PID) running in the guest kernel. So it can not segregate memory pages according to the process. Therefore, this paper proposes an efficient method for the host kernel to obtain the memory page information to partition the memory for each process in DCM, called MFence. The MFence was evaluated using two Linux servers connected by a 100 Gbps IB network. Extensive evaluation has confirmed that MFence ideally provides memory partitioning to provide fairness between processes and improve overall performance.


The achievements of new rural cooperative medical system in Dunhuang in recent years are introduced.The main problems are analyzed,and the corresponding improvement measures are put forward.


This paper discusses the problem of finding the maximum number of edges E(m, n, B) in a bipartite graph having partite set sizes m and n and bandwidth B. Exact values for E(m, n, B) are found for many cases. © 2000 John Wiley & Sons, Inc. J Graph Theory 35: 278–289, 2000


Although this looks superficially similar to the examples we considered last week, there is an important distinction. To this point in our study of twodimensional systems, we have only allowed the state variables x and y (and their derivatives) to appear linearly in the governing differential equations. The term x2 in (1), however, is nonlinear. Although this may seem like a small modification, it is enough to render last week's methods incapable of determine an analytic solution—in fact, we can no longer even write it in the standard matrix form x′(t) = Ax(t) since this depended implicitly on x and y appearing linearly in (1). It is clear that we will need a new set of tools if we wish to determine the behavior of systems like (1). We start by defining the general class of autonomous non-linear two-dimensional systems


Ergonomic, Emotional and House Automation (Domotic) analysis, are essential for process planning, job design, the design of tools/machine/equipment and work station set up. Human safety and comfort have become a key factor in maximizes the labor productivity and life quality. With the evolution of digital technologies, the analysis and simulation of the human factor in work processes are acquiring a major role. The use of advanced approaches in innovative technologies, such as ergonomic analysis tools in the future digital factory and physical environment, contributes to achieving continuous improvement in the management of quality while searching for reserves in managing human factor reliability. This paper presents a teaching methodology for an integrated project related with industrial and systems engineering and mechatronic engineering; which the main objective is to set the stage when the work systems design begins. The paper comprises theoretical starting points, results of laboratory verification and results in outputs.


An arc radiant spectrum collecting system is constructed. The breaking arc radiant spectral intensities of low-voltage circuit breaker are measured by this system. Furthermore the temperature distribution of arc column can be calculated. The result shows: the temperature reached maximum in the prophase of arc burning. With the movement of contact the arc was stretched gradually and its high temperature areas gathered toward both ends. The temperature of its middle part dropped dramatically first, then the arc column was broken and it was quenched along with its temperature drop-off.


ABSTRACT An American novelist of Chinese origin, Amy Tan attempts to reconstitute the American experience for both the first and second generation Chinese immigrants in her fictional discourses. Curiously, she defiantly promotes the idea of a re-created identity through assimilation, even while she is aware of the inability of Asian Americans to discard their ethnicity and disappear into the American culture. Significantly, Tan's fictional Asian American characters not only justify their ethnic affiliation but also assert the importance of variance within the American culture by challenging the status-quo of American identity. However, this assertion of the Asian American subjectivity within the multicultural context of America further reinforces the insurmountable cultural differences between the scientific Western 'self' and the exotic Eastern 'other,' leading to the production of hybrid or alchemised characters, rather than monolithic Americans. Focusing on her use of exotic and supernatural tropes in The Hundred Secret Senses, this paper probes how Tan astutely perpetuates occidental and oriental stereotyping in her fictions and thereby indulges in New Age Ethnicity or neo-Orientalism, as a part of her aspiration to belong to the white American intellectual circle.


Deep Neural Networks (DNNs) are the state-of-art solution in a growing number of tasks including computer vision, speech recognition, and genomics. However, DNNs are computationally expensive as they are carefully trained to extract and abstract features from raw data using multiple layers of neurons with millions of parameters. In this dissertation, we primarily focus on inference, e.g., using a DNN to classify an input image. This is an operation that will be repeatedly performed on billions of devices in the datacenter, in self-driving cars, in drones, etc. We observe that DNNs spend a vast majority of their runtime to runtime performing matrix-by-vector multiplications (MVM). MVMs have two major bottlenecks: fetching the matrix and performing sum-of-product operations. To address these bottlenecks, we use in-situ computing, where the matrix is stored in programmable resistor arrays, called crossbars, and sum-of-product operations are performed using analog computing. In this dissertation, we propose two hardware units, ISAAC and Newton.In ISAAC, we show that in-situ computing designs can outperform DNN digital accelerators, if they leverage pipelining, smart encodings, and can distribute a computation in time and space, within crossbars, and across crossbars. In the ISAAC design, roughly half the chip area/power can be attributed to the analog-to-digital conversion (ADC), i.e., it remains the key design challenge in mixed-signal accelerators for deep networks. In spite of the ADC bottleneck, ISAAC is able to out-perform the computational efficiency of the state-of-the-art design (DaDianNao) by 8x. In Newton, we take advantage of a number of techniques to address ADC inefficiency. These techniques exploit matrix transformations, heterogeneity, and smart mapping of computation to the analog substrate. We show that Newton can increase the efficiency of in-situ computing by an additional 2x. Finally, we show that in-situ computing unfortunately cannot be easily adapted to handle training of deep networks, i.e., it is only suitable for inference of already-trained networks. By improving the efficiency of DNN inference with ISAAC and Newton, we move closer to low-cost deep learning that in turn will have societal impact through self-driving cars, assistive systems for the disabled, and precision medicine.


The T-x data for 1, 1, 1-trichloroethane-1-propanol mixtures have been measured ebulliometrically at 1O1.3-kPa pressure. The system shows positive deviations from Raoult's law, forming a minimum boiling azeotrope. The vapor compositions have been predicted by using UNIQUAC and CLC models


OBJECTIVE
To examine the extent and the significance of the psychologic mechanism of denial in coronary heart disease. This problem is known to be frequent, but its significance remains controversial.

DATA SOURCES
From the bibliographies of recent publications, the author traced 21 empirical studies on denial in coronary heart disease published during the last 25 years.

STUDY SELECTION
For a chronologic and historical approach all the studies were retained. The oldest had a qualitative and descriptive approach; the most recent used a scale of measurement.

DATA EXTRACTION
This review examines the clinical data found in the publications and does not critically analyse the measurement tools.

RESULTS
The results show that the ambiguity of the question arises from three aspects that have to be clarified: (1) there is a difference between the short-term effect and the long-term effect of denial in coronary heart disease; (2) part of the contradictory results could be linked to the scale of measure; and (3) the concept of denial is a notion that is used in an equivocal way that is not clarified even by the precision of the scale of measurement.

CONCLUSIONS
Persistence of denial would have negative effects in the long term. The scale of Hackett and Cassem is useful in measuring denial in the acute stage but not in the rehabilitation stage. The very notion of denial is used ambiguously in several of the studies examined.


The five step digital filter has been developed which removes components other than those of QRS complex from the recorded electrocardiogram (ECG). The final step of the filter produces a square wave whose on-intervals correspond to the segments with QRS complexes in the original wave.


A field-induced crossover is observed in the resistivity and magnetization (M) of a La(0.7)Pb(0.3)MnO(3) single crystal. The field-dependence of the resistivity and M suggests that a small spin-canted species with mean-field-like interactions dominates at low fields (H), whereas, individual spins and 3D Ising/Heisenberg models describe the high-H behavior rather well. Around the ferromagnetic transition, an H-induced destruction of the small spin-canted magnetic polarons is accompanied by large magnetoresistance.


Some possible non-steroidal antiprogestins were evaluated for their receptor binding activity by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of the 42 compounds belonging to 5 different series tested, dimethyl ester of monobenzylidene succinic acid, 4-ethoxycarbonyl-3-(m-methoxybenzyl)-5-(m-anisyl)-gamma-butyrolact one and 2-(3-benzyl-oxybenzyl)-3-(3-acetoxybenzyl)butane-1,4-diol exhibit around 20% inhibition of 3H-progesterone binding to uterine cytosol in both species.


The concept of virtual power plants (VPP) was introduced over 20 years ago but is still actively researched. The majority of research now focuses on analyzing case studies of such installations. In this article, the investigation is based on a VPP in Poland, which contains hydropower plants (HPP) and energy storage systems (ESS). For specific analysis, the power quality (PQ) issues were selected. The used data contain 26 weeks of multipoint, synchronic measurements of power quality levels in four related points. The investigation is concerned with the application of a global index to a single-point assessment as well as an area-related assessment approach. Moreover, the problem of flagged data is discussed. Finally, the assessment of VPP's impact on PQ level is conducted.


As the state of California deals with severe budget cuts due to a suffering economy, programs offering services to those with disabilities are often the first to lose funding and close their doors to the public; the closing of the Clubhouse program was no exception to this trend. As of late June of 2010, UCLA Medical Center closed the Clubhouse program due to a lack in funding. While it was still in operation, the Clubhouse program served the Los Angeles community as a social-recreational program for children with autism, between the ages of three and six years old. The program aimed to better equip its participants with social skills that would help them better assimilate into their immediate community, which can include their elementary school or local YMCA. The purpose of this study is to pinpoint the specific reasons behind this decision made by the UCLA Medical Center. In accomplishing this task, this study will investigate different issues. First, this study will attempt to understand the context in which the program functioned by situating the program within the UCLA Medical Center and the larger Los Angeles area. Going further, this study will look into why the Clubhouse closed rather than other programs, such as ECPHP (Early Childhood Partial Hospitalization Program), which similarly offer services to children with autism. Possibly, how the medical center classified the Clubhouse program might have made the program a more preferred candidate for closure. Lastly, this study will investigate the perceptions of disability within the UCLA medical community and how the medical model of disability affects budget decisions made in the hospital setting.


We study the collective phenomenon in the scattering of a single photon by one or two layers of two-level atoms. By modeling the photon dispersion with a two-dimensional coupled cavity array (2D CCA), we analytically derive the scattering probability of a single photon. We find that the translational symmetry of the atomic distribution leads to many important effects in the single-photon scattering. In the case with one layer of atoms, the atomic collective Lamb shift is related to the photonic density of states (DOS) of a 1D CCA, rather than the photonic DOS of a 2D CCA. As a result, the photon is effectively not cattered by the atoms when the incident momentum of the photon takes some special values. In the case with two layers of atoms, an effective coupling between two layers appears and induces an electromagnetically induced transparency like phenomenon. Our work provides a scheme of analyzing photon coherent transport in 2D and may help to understand recent experiments related to high-energy photon scattering by layered nuclei material.


In an offshore wind HVDC system, one option for connecting the variable speed wind turbine/permanent magnet generators to the DC grid is via passive rectifiers in series with DC/DC converters. This paper focuses on the DC/DC converters in the PMSG-rectifier-DC/DC converter the system. Three DC/DC converter topologies are investigated supplied by MW level PMSG wind generators. The topologies include the Phase Shift Full Bridge Converter, Series Load Resonant (SLR) Full Bridge Converter and Thyristor Based Resonant Converter. Detailed models of the DC/DC converters are built in the PLECS simulator. A 15kW 150V/600V 500Hz Phase Shift full bridge DC/DC converter prototype has been built to validate the simulations.


As part of the evaluation of the "Quit. For Life" smoking intervention, 5,713 people in Sydney and Melbourne were asked to order a list of seven health issues in order of community concern. Drink driving appeared to be the major issue, with over 70 per cent in Sydney and nearly 90 per cent in Melbourne placing it in the top three issues. Smoking and stressful lifestyle rated next most highly and were followed by high blood pressure, lack of exercise, weight and cholesterol in that order of perceived importance. Drink driving was ranked most highly by the 14–29 year age groups and teenagers gave the highest priority to smoking.

The working age population of both sexes rated stress as more important than did other groups. Older age groups were more concerned with blood pressure and women more so than men. Younger people saw exercise as more important than did older people but a large proportion of all age and sex groups ranked exercise as being of least importance. An unexpected result was that, although older people rated weight as important, there was no sex effect. People appeared unwilling to nominate cholesterol as either important or unimportant, possibly indicating confusion about its relation to health. Suggestions are made as to how these findings can be used to promote healthy lifestyles.


The tridecapeptide NH2-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-COOH has been purified from extracts of bovine posterior pituitary glands. This unique peptide, which has been given the name "rimorphin," is a major [Leu]-enkephalin-containing peptide in all tissues examined that contain dynorphin and a-neo-endorphin. However, except for the initial hexapeptide sequence, it is structurally unrelated to the other two peptides. The [Leu]enkephalin-containing peptides ([Leu]ECPs) dynorphin and a-neo-endorphin have been shown to possess potent opiate activity in certain in vitro bioassay systems (1, 2). These peptides have been detected in several tissues, including hypothalamus, spinal cord, and posterior pituitary gland (1, 3-6). However, there have been no studies attempting to character-ize the other ECPs present in tissues that contain a-neo-en-dorphin and dynorphin. During such studies in the bovine posterior pituitary gland we observed a unique [Leu]ECP that did not correspond to any previously identified peptide. Details