The guanosine-adenosine-rich exonic splicing enhancer (GAR ESE) identified in exon 5 of the human immunodeficiency virus type-1 (HIV-1) pre-mRNA activates either an enhancer-dependent 5′ splice site (ss) or 3′ ss in 1-intron reporter constructs in the presence of the SR proteins SF2/ASF2 and SRp40. Characterizing the mode of action of the GAR ESE inside the internal HIV-1 exon 5 we found that this enhancer fulfils a dual splicing regulatory function (i) by synergistically mediating exon recognition through its individual SR protein-binding sites and (ii) by conferring 3′ ss selectivity within the 3′ ss cluster preceding exon 5. Both functions depend upon the GAR ESE, U1 snRNP binding at the downstream 5′ ss D4 and the E42 sequence located between these elements. Therefore, a network of cross-exon interactions appears to regulate splicing of the alternative exons 4a and 5. As the GAR ESE-mediated activation of the upstream 3′ ss cluster also is essential for the processing of intron-containing vpu/env-mRNAs during intermediate viral gene expression, the GAR enhancer substantially contributes to the regulation of viral replication.


The main purpose of this study is to develop some activity plans by 7E model of the constructivist approach on the subjects of acid, base and indicators in physical science course. Constructivist 7E approach consists of seven stage such as Elicit, Engage, Explore, Explain, Elaborate and Extend. Many activities related to physical Science subjects about 'Acid, Base and Indicators' were adapted by each and every stage of constructivist 7E approach. The activity plans were arranged for acquisition knowledge of physical science course. So, the application duration of the activities was determined by these acquisitions. A learning design by 7E model of constructivist approach of acid base and indicators in physical science course using mind mapping techniques.


We have investigated the stability and catalytic activity of epitaxial overlayers of rhodium on Au(111) and Pd(111). Both surfaces show a strong affinity for hydrogen. We have calculated the energy of adsorption both for a strongly and a more weakly adsorbed species; the latter is the intermediate in the hydrogen evolution reaction. Both the energy of activation for hydrogen adsorption (Volmer reaction) and hydrogen recombination (Tafel reaction) are very low, suggesting that these overlayers are excellent catalysts.


Conclusions A clonal strain (MH1C1) of rat hepatoma cells synthesized labeled bilirubin with either glycine-2-14C or δ-ami-nolevulinic acid-3,5-3H as precursor. In contrast to the findings in living rats, labeled bilirubin production is only slightly enhanced in MH1C1 cells that have been preincubated with phenobarbital. These studies indicate that hepatic parenchymal cells are capable of producing at least part of the nonerythroid fraction of bile pigment. Moreover, they provide a unique experimental model for the further study of hepatic heme and bilirubin metabolism.


Sharing of health data should improve patient safety and improve health services efficiency. These data can also be used for research. The shared data are usually "coded" using a coding system classification or nomenclature. However, "coding" is not a neutral action and is part of the complex social interaction between doctor and patient To derive meaning from data it is essential to understand the context in which it is recorded and to infer whether data recorded for one purpose is usable in another. Most of the existing models to raise data quality (DQ) are descriptive and don't necessarily inform why lessons from one health system might be applied in anther.


A public key encryption scheme with keyword search capabilities is proposed using lattices for applications in multiuser environments. The proposed scheme enables a cloud server to check if any given encrypted data contains certain keywords specified by multiple users, but the server would not have knowledge of the keywords specified by the users or the contents of the encrypted data, which provides data privacy as well as privacy for user queries in multiuser environments. It can be proven secure under the standard learning with errors assumption in the random oracle model.


This article described basic conception of guarantee and counter-guarantee. The kinds and some workable measures of counter-guarantee are also presented.


Examining patterns in suburban density and mix in a mid-sized Canadian city illustrates the challenges of trying to achieve planning targets for urban intensification and mixed use in mid-sized cities with relatively slow rates of growth. A mixed methods study documents trends in Halifax over a 50-year period. Although planning theory and policy often promote growth nodes and corridors, the case study illustrates the ways in which market forces, conflicting regulations, demographic shifts, and local conditions may undermine efforts to increase densities and generate fine-grained mixing of uses and housing types in suburban areas.


In previous work, the normal surface displacement patterns of thick barium titanate disks vibrating in various normal modes have been obtained using multiple‐beam optical interference. This technique has now been used to determine the effect of loading a disk with a liquid in contact with one plane surface. It is found that the discrete modes observed with an unloaded disk begin to merge so that the vibration patterns show a continuous transition with changing frequency as one passes from one mode to the next in the "thickness resonance" region. The radiation damping of the individual modes is appreciably less than the theoretical value, but the bandwidth covered by the group is appreciably greater than is to be expected from the simple theory of thickness resonance. In the case of a quartz disk, two modes with a frequency separation of 0.5% merge fairly completely when the disk is loaded, and the vibration patterns indicate composite motion of a more uniform character than that of either mode alone.


Three years ago (1946) I presented a paper to the Academy of Sciences in Ferrara (1) and to the Medical-Surgical Society of Modena (2), in which a new method for the roentgenokymographic study of the organs with curved borders, like heart, diaphragm, stomach etc. was proposed. I suggested to substitute the usual grid with parallel slits, with a grid with radial slits, like the spokes of a wheel the center of which cor responds to the center of the examined organ. I knew, later on, that such a method had been proposed in 1935 by


Cardiovascular disease is a major consequence of diabetes and is associated with peculiar features in this subgroup of patients, representing roughly 25% of the total population treated with percutaneous coronary interventions (PCIs). A consistent proportion of these patients have asymptomatic myocardial ischaemia, which is a more extensive and diffuse atherosclerotic disease with more prevalent multivessel disease. The diabetic milieu (hyperglycaemia and increased oxidative stress) favours plaque instability.1 Coronary revascularisation – using PCIs and/or coronary artery bypass grafts (CABGs) – has a worse prognosis in terms of repeat interventions and mortality in diabetics compared with the non-diabetic population.2,3 In particular, higher rates of repeat revascularisation due to restenosis have been seen after balloon and stent PCI. In the biochemical cascade responsible for neointimal hyperplasia, a near-normal glucose level seems to have a protective effect before and after revascularisation.4


Progress in the laparoscopic techniques has made it possible to remove an abdominal testicle in the standing horse. As abdominal cryptorchidism is usually unilateral, the descended testicle is removed using a classic standing castration technique. However, this latter technique is not considered ideal as it is difiicult to guarantee asepsis, and can be dangerous for the surgeon. Therefore, a study was initiated to castrate descended testicles in the standing horss using a laparoscopic technique. In six Welsh pony stallions, 2 years of age, each with 2 descended testicles, the mesorchium, including the testicular artery and vein, are ligated intraabdominally and the testicles are left in place. The measurements of plasmatestosteron levels, the clinical examination and the results of the necropsy of the ponies 5 months postoperatively revealed, that the testicles atrophy and were no longer functional. Also, the results of the surgery on I unilateral inguinal cryptorchids, one bilateral inguinal cryptorchid, 17 unilatetal bdominal cryptorchids (ot which 5 were castrated unjlateralJy), 2 bihteral abdominal cryptorchids and 12 .normal " stallions are described. In conclusion, the surgical technique described in this repon is a safe and efficient method of castrating descended testicles in the standing patient. Advantages include reduced tissue trauma, no risk because of general anaesthesia, quicker return to normal work and reduced hospitalization time.


Untethered magnetic microrobots hold the potential to penetrate hard-to-reach areas of the human body and to perform therapy in a controlled way. In the past decade, impressive advancements have been made in this field but the clinical adoption of magnetoresponsive microrobots is still hampered by safety issues. A tool appointed for magnetic microrobots retrieval within body fluids could enable a real paradigm change, fostering their clinical translation.By starting from the general problem to retrieve magnetic microrobots injected into the bloodstream, the authors introduce a magnetic capture model that allows to design retrieval tools for magnetic cores of different diameters (down to 10 nm) and in different environmental conditions (fluid speed up to 7 cms-1). The model robustness is demonstrated by the design and testing of a retrieval catheter. In its optimal configuration, the catheter includes 27 magnets and fits a 12 F catheter. The model provides a good prediction of capture efficiency for 250 nm magnetic particles (experimental data: 77.6%, model prediction: 65%) and a very good prediction for 500 nm particles (experimental data: 93.6%, model prediction: 94%). The results support the proposed model-based design approach, which can be extended to retrieve other magnetoresponsive agents from body compartments.


This work builds on complexity theory in order to identify different types of learners that use video-based learning (VBL). VBL has great value as an educational tool which has already been identified in various contexts. This study combines learners' demographics with learners' experience in a conceptual model to explain the adoption of VBL technologies. We test and validate the proposed model through a survey on 260 VBL users, by implementing the data analysis tool fsQCA (fuzzy-set Qualitative Comparative Analysis). The findings indicate eight configurations of learners' demographics and learners' experience that lead to high intention to adopt VBL. The results take a step further the literature of VBL by taking a different approach and implementing a different methodology, which has recently started to receive increasing attention. We also offer theoretical and practical implications by identifying distinct types of learners that have high behavioral intentions towards VBL.


This international project set out to 'distil' the UNECE educator competences for ESD to create a more concise framework of assessable learning outcomes that can form the basis of ESD qualifications for in-service and student educators across Europe.


We study the order of the Higgs phase transition in the SU(2) Higgs model at several values of the gauge coupling {beta} for bare quartic coupling {lambda}=0.5 using Monte Carlo simulations. We determine the internal energy of metastable states on various lattice sizes and estimate that the transition terminates at the critical point located at 1.95{lt}{beta}{sub {ital c}}{lt}2.25. We also apply a recently proposed multihistogram method in our data analysis. At {beta}=2.25 and {beta}=2.4 our data strongly indicate the presence of a first-order phase transition. For {beta}{ge}2.6 we find no indication of a discontinuity in the internal energy on lattices up to size 16{sup 4} and the transition is either weakly first order or of higher order.


The bicyclo[4.3.0]nonane ring system of the pinguisane-type sesquiterpenoid natural products, including the vicinal quaternary stereocentres, has been synthesised as a single enantiomer via a novel Bronsted acid promoted transannular alkylation of an enol with an unactivated alkene.


At the end of the twentieth century, the United Arab Emirates (UAE) enjoys a favorable strategic position compared to the rest of the southern Gulf states. The federation faces no immediate threat of invasion, overwhelming debt, organized domestic opposition or economic collapse. The emirates' rivalries have largely abated and there appears to be the beginnings of a federal civil society. In addition, the United States ensures the federation's security. Yet the UAE must grapple with the same challenges that have Afflicted the poorer Middle East states: rapid population growth, lack of economic diversification, low oil prices, low water supplies and dependence on foreign labor. At the same time, the UAE's most charismatic leader and only president -- Abu Dhabi Ruler Shaykh Zayid -- is in poor health and lacks a strong successor. Some analysts question whether the federation's will remain unified after Zayid's death. Moreover, the UAE's military forces -- either on their own or in combination with those of the GCC -- cannot deter the federation's principal security threat, Iran. The federation claims that Iran illegally occupies Abu Musa and the Greater and Lesser Tunbs, but Tehran has refused to relinquish control over these three islands. UAE officials believe that the best way to restrain Iranian expansion in the southern Gulf is to integrate a unified, militarily strong Iraq into the Gulf's balance of power. The problem with this strategy is that the United States, which currently dominates the Gulf's military balance, believes that the current regime in Baghdad threatens regional security and opposes any plan that would reintegrate Iraq into an international security structure.


We present the first SDN-enabled multi-domain multi-layer (WDM/SDM) control architecture for partially disaggregated optical networks with multiple WDM and SDM OLS domains and transponders to provision end-to-end TAPI connectivity services involving spatial and optical channels.


Borrowing from the Latin poet Horace, Immanuel Kant framed the European Enlightenment with the motto: Sapere aude ('dare to know') (Kant, 1784). What impressed itself upon him was not the content of the knowledge claims being made by the Philosophes whose work had sought to transform economic, social, religious and intellectual life through the application of reason, but the attitude or spirit by which enquiry was being undertaken. Whether knowledge was added to or supplanted was secondary to the process by which the world, and oneself as part of it, was continually opening up. Sapere means to understand, but also to taste, and enthusiastically so, such that the Spanish have the expression con sabor, 'with gusto'. What configures enlightenment is the experience of knowledge being created and savoured, especially when daring to push at the edges of convention, to enquire along the limits of common sense. To taste and to dare are far from metaphysical experiences, they are rooted in one's empirical awareness; enlightened knowledge remains with life and the things of life. For Kant, any prospect of an end point, an enlightened age, was a distraction; enlightenment is experienced in the undertaking of study rather than in its completion. This undertaking finds complicity between what is being claimed as truthful and the endeavour of enquiry. Kant stresses that it comes through assays, speculation and experiment, and in full awareness of two things. Firstly, the researcher must rely in the undertaking upon other people and events; enlightenment is a collective experience. Secondly, the undertaking demands flexibility as the making of knowledgeclaims occurs in an awareness of this involvement with others and otherness, as well as of the inscrutable nature of things. 'Daring to know' is the experience of respecting and upending the world into which we are thrown through enquiry that occupies the space between ordinary, everyday understandings and distant, generalized assertions. We believe that since its inception Organization Studies has been a journal that in many ways subscribes to such an enlightened attitude to and perspective on the study of organizations, organizing and the organized. This is clear from re-reading the editorial introduction to the first issue of the journal (Hickson et al., 1980). Since then, technologies, economies and societies have obviously changed, but the underlying spirit and ideas expressed in that editorial continue to resonate. They serve us well as broad prompts for how we view and intend to animate Organization Studies. Hickson and his colleagues (1980, p. 1) asserted:


Objective It is to evaluate the significance of tumor specific growth factor (TSGF) in diagnosis of ovarian malignant tumor. Methods Serum TSGF levels in 43 patients with ovarian malignant tumors, 50 patients with ovarian benign tumors and 50 normal people were measured with colorimetry. Results The serum TSGF level in malignant group was significantly higher than that in benign group and control group ( P 0.01). The serum TSGF level in phase Ⅲ to phase Ⅴ malignant tumor patients was higher than that in phase Ⅰ to phase Ⅱ malignant tumor. The sensibility and specificity of serum TSGF for diagnosis of ovarian malignant tumor were 79% and 92%. Conclusion Serum TSGF concentration was important in early diagnosis of ovarian malignant tumor.


Fly ash stabilization is one of the methods of soil stabilization. It is used in many fields in the world, especially in highway engineering since many years ago for changing the soil characteristics so that the soil becomes more suitable for road construction. The main objective of this study is to determine the relationship between the thickness of pavement with the percentage of fly ash and to determine the cost of pavement construction for different thickness of pavement structure. Subgrade stabilization is
usually been done with addition of lots of material such as Portland Cement, lime, and bottom ash. The California Bearing Ratio (CBR) values including the addition of 4% and
8% of fly ash had been used in pavement design to determine thickness of the pavement using original sample and different percentage of additive. As the thickness of the
pavement varies, the cost of constructing the road pavement structure has been calculated to get the minimum cost by comparing between the cost calculated for original, 4% and
8% of fly ash. From the CBR test result, the CBR value of the sample increase from 4.40% to 4.49% with increasing the percentages of additive. Overall, the addition of fly
ash to the original sample has increased the value of CBR thus decreasing the cost of constructing the road pavement structure.


A series of β-halogenated cationic metalloporphyrins were analyzed by LDI-TOF and ESI-MS. Although LDI-TOFMS reveals to be a good tool for the characterization of this family of metal-complexes, including the redox state of the metal, ESI-MS indicates in addition the relative tendency of such metal-complexes to be reduced.


Nowadays translators have countless resources to assist them in their task. Knowing how to use these resources is part of the instrumental sub-competence (HURTADO ALBIR, 2005, 2015a, 2015b; PACTE, 2009). Undoubtedly, it is necessary to have translation competence to surf amid a barrage of material, much of which is made available in electronic format. But if, on the one hand, translators need to know how to use the resources offered to them, on the other, it is necessary to develop material that is practical, effective and reliable. The lack of reference material to deal with the Rev. Estud. Ling., Belo Horizonte, v. 30, n. 1, p. 269-292, 2022 270 translation of medical abbreviations was the basis for the creation of a (Portuguese/ English) bilingual glossary of abbreviations in the field of rheumatology. Although these shortened forms are recurrent in the medical text, they continue to challenge translators. This article describes some of the phases of the creation of this glossary and discusses the relationship between the preparation of reference material and the instrumental sub-competence.


On 14 March 2013, the Court of Justice of the European Union ("ECJ") handed down a judgment on a reference for a preliminary ruling from the Hungarian Supreme Court on the application of…


During the period of social transition,the interest of the underclass is undermined as a result of the imbalanced interest games among different parties. The "group events"can be interpreted as a kind of "mob action",i.e.,the young people from the underclass attempt to express their appeal of interest by means of protesting through social media. The social media has become an increasingly important channel for the underclass to express interest requirement,which is known as organized media protest. We analyze the process and reason of organized media protest from such aspects as boundary,awareness and dialogue so as to reveal how the young people from the underclass struggle for the rights through organized media protest. Finally,we offer a path that goes around "self- empowerment"to relieve the organized media protest.


1 Community Health Improvement: A Framework for Alignment and Shared Accountability Public Forum Well, here we go. I would ask our first panel to come up. I'm going to do a quick run-through of ground rules. While I appreciate the fact that folks are putting the kinds of questions and topics on the table that we need to begin to address right off the bat, and for Steve beginning to move us into that deep dive that we want to take here, many of you know because it's been on the agenda, I just want to recap our approach to each of the 13 panels. Each of the panelists will have, for three-person panels, 10 minutes each, for twoperson panels, 15 minutes each, to offer their comments, their perspectives on the set of questions that relate to each panel from their experience and in their context. As a public forum, our primary focus is on public questions and comments, so after I do some brief follow up with each of the panels to flesh issues out a little further, we'll have 30 minutes of public comment and question. We're going to have three folks with mics who are going to be available. What we're going to try to do is to get three comments or questions in a row from folks.


QUS parameters are closely related to the structural properties and elastic properties of bone, which can provide important information related to bone quality and bone strength. One should be very careful, however, that bone contains complicated structure from microscopic to macroscopic levels. For example, the cancellous bone inside the epiphysis is composed of a complicated trabecular network in the bone marrow, showing strongly anisotropic and heterogeneous structure. We have then observed the longitudinal wave propagation in this complicated medium, paying special attention to the two wave phenomenon. The fast wave, which mainly propagates in the trabecular part of the cancellous bone, is more sensitive to the network structure. With the help of x‐ray micro‐computed tomography, three dimensional anisotropic trabecular structure and fast wave propagation were investigated using bovine cancellous bones. We can find the strong effect of anisotropic trabecular structure on the fast wave velocity. The mean intercept length (the information of average trabecular length) was a good parameter to describe the three dimensional trabecular structure and showed good correlation with the fast wave velocity.


Smart Factories require new sensor systems to collect important data and to link different parts of a factory together in order to control it automatically. In this paper a low-power and low-cost radar system with a power consumption of 1.5mW at a sampling rate of 10 measurements per second is presented. By using a multitone approach, the unambiguous range can be enhanced significantly and the system is made more robust against influences from harsh industrial environments. It can be used for applications as tank level measurements or piston monitoring in waveguides and is designed for the 24 GHz Industrial, Scientific and Medical (ISM) band.


Effective forecasting the heating temperature of great-circle cylindrical steel ingot is one of important topics in many large-scale forging factories and steel mills.The analytic solution of heat conduction differential equation was given,the heating characteristic of great-circle cylindrical steel ingot was studied,the heating rate,the size of steel ingot cross section as well as the influence of heating furnace temperature on heating time of surface and center of steel ingot were analyzed,the key to heating quality and the way of reducing heating time were pointed out.


This article discusses the proposed Twenty-Seventh Amendment, controlling variances in Congressional pay, through the context of the nearly identical second amendment contained in the original proposal for the Bill of Rights.


A simple design for an inexpensive, compact, desktop-sized helium free-jet beam source is described. The apparatus, which is Campargue-like in design and utilizes mostly off-the-shelf parts, is capable of producing a centreline intensity of 1.2 × 1019 atoms per second per steradian. The beam performance was investigated using a conventional ion gauge and a stagnation detector, with the latter being used to produce beam flux profiles. The profile of the macroskimmed beam has been experimentally demonstrated to be strongly Gaussian.


Graphs are powerful data structure for representing objects
and their relationships. They are extremely useful in the study
of dynamical systems, evaluating how different agents interact
among each other and behave. An example is represented
by the consensus problem where a graph models a
set of agents that locally interact and exchange their opinions
with the aim of reaching a common opinion (consensus
state). At the same time, many learning techniques rely
on graphs exploiting their potentialities in modeling the relationships
between data and determining additional features
related to the data similarities. To study both the consensus
problem and specific machine learning applications based on
graphs, the study of the spectral properties of graphs reveals
fundamental. In the consensus problem, the convergence rate
to the consensus state strictly depends on the spectral properties
of the transition probability matrix associated to the
agents network. Whereas graphs and their spectral properties
are fundamental in determining learning algorithms able
to capture the structure of a dataset. We propose a theoretical
and numerical study of the spectral properties of a network
of agents that interact with the aim of increasing the rate of
convergence to the consensus state keeping as sparse as possible
the graph involved. Experimental results demonstrate
the capability of the proposed approach in reaching the consensus
state faster than a classical approach. We then investigate
the potentialities of graphs when applied in classification
problems. The results achieved highlight the importance
of graphs and their spectral properties handling with both
semi–supervised and supervised learning problems.


The sensitivity of Sylvester matrix equations relative to perturbations in the coefficient matrices is studied. Local perturbations bounds are obtained.


The Poria cocos have high value of application in the pharmacognosy,pharmaceutical chemistry,pharmacology,pharmaceuticsa and clinical application.The advance in Poria cocos are introduced in this paper,the study of traditional Chinese medicine,chemical constituents,the major is polysaccharide,it can anti-aging and enhance immunity,pharmacological activity of Poria cocos are involved.And prospect the perspective of application.It provides some references for further research of hygienic medicine.


A new coordination polymer [Ag2L1.5(NO3)2(CH3CN)]n (1) (L = N,N′-bis(furan-2-ylmethylene)hydrazine) has been synthesized and characterized by IR, UV, elemental analysis, 1H NMR, and X-ray crystallography. The most remarkable structural feature of the polymer is that it displays a 2D coordination polymer featuring three types of metallacyclic rings, bimetallic 8-membered, tetrametallic 14-membered, and hexametallic 20-membered rings. The luminescent properties of the title polymer were investigated in the solid state at room temperature.


Crohn disease (CD) and Ulcerative colitis (UC) are characterised by episodes of exacerbations and remissions. Monitoring disease activity based on intestinal lesion is mandatory prior to any change in the therapeutic strategy. Colonoscopy is the gold standard technique to monitor the disease activity in IBD patients, but it is usually discarded because of costs and risk issues. The concentration of Faecal Calprotectin (FC) is widely used as a non-invasive marker of inflammation of the intestinal mucosa, allowing the assessment of the disease activity. Recently, different studies have demonstrated that certain microbial species, part of intestinal microbiota which can be detected in stool samples, are capable of correlating with disease activity in CD and UC patients. The purpose of this study was to analyse the correlation between these microbial indicators and the FC to monitor the disease activity in CD and UC patients.

 FC levels were used to define inflammatory disease activity, the predetermined cut-off of 250 μg/g of faeces was used, higher values indicated an active inflammation and lower values indicated disease in remission. Two cohorts consisting of 61 patients of CD (25 with active inflammation and 36 with remission) and 90 of UC (42 with active inflammation and 48 with remission) were recruited by the Gastroenterology department of 4 Catalan hospitals. A sample of faeces was collected from each patient. FC and the following markers were quantified by qPCR: Faecalibacterium prausnitzii (Fpra), Escherichia coli (Eco), Akkermansia muciniphila (Akk), Ruminococcus sp. (Rum), Bacteroidetes (Bac) and Methanobrevibacter smithii (Msm) for each sample.

 The bacterial markers presented different behaviour depending on the disease analysed. The abundances of Eco and Bac were higher in CD with active inflammation compared with CD with remission. In contrast, no significant differences were found for Fpra, Akk, Rum, and Msm. Besides, a significant positive correlation between Eco abundance and FC levels (0.280, p = 0.029) and a significant negative correlation between Msm and FC levels (−0.299, p = 0.021) were observed.
 According UC patients, while the abundance of Eco was higher in patients with active inflammation, the abundance of Rum was significantly less abundant. No significant differences were found for Fpra, Akk, Bac, and Msm. Moreover, we also observed a significant negative correlation between Rum and FC levels (−0.308, p = 0.003, respectively).

 The abundance of Eco and Msm in CD patients and the abundance of Rum in UC patients correlate to FC in order to determine inflammatory disease activity. So, these markers can also be an accurate discriminator of active disease in CD and UC patients.


The invention relates to a diatom ceiling with a humidity adjustment function, and a preparation method thereof. Current ceilings are prone to deformation after absorbing moisture, and have no humidity adjustment function. The invention mainly aims at solving the above problems. The diatom ceiling with the humidity adjustment function is composed of the raw materials of diatomite, a calcareous raw material and a fiber material with a mass ratio of 100:20-60:0.2-1.2. The mass of mixing water is 10-50% of the total mass of the above diatomite, calcareous raw material and fiber material. The invention also provides the preparation method of the diatom ceiling. The method comprises the specific steps of raw material preparation, roasting activation, material blending and well mixing, pressure molding, hydrothermal solidification, drying dehydration, and finished product treatment. The diatom ceiling provided by the invention has technical features of light weight and high strength. With the corresponding preparation method, water molecule large-capacity fast absorption and release are realized.


Objective To study in vivo tumor inhibition effects on tumor-draining lymph nodes (TDLN) cells in nude mice.Methods TDLN mice were cultured in 3 groups:IL-2 was added to the culture medium in TDLN-Ⅰ group,IL-2+IL+GM-CSF in TDLN-Ⅱ group,IL-2+IL-4+GM-CSF+tAg in TDLN-Ⅲ group.The mice were divided randomly into groups blank control,IL-2,TDLN-Ⅰ,-Ⅱ,-Ⅲ,which were injected with NS,IL-2,TDLN cells,respectively.Tumor volume of nude mice were measured and recorded once per week.Mice were sacrificed to remove transplanted tumor samples and tumor cell apoptosis detected by flow cytometry.Results There was significant difference in tumor volume between 5 groups at different time of experiment (F=30.020,P0.01).A further analysis showed that no significant difference was noted in tumor volume between groups control and IL-2 (P0.05).Tumor volume decreased in groups TDLN-Ⅰ,Ⅱ,Ⅲ as compared with groups control and IL-2,the difference was significant (P0.01),and TDLN-Ⅰ were significantly different from TDLN-Ⅱ (P0.05).There was significant difference in tumor apoptosis rate between 5 groups (P0.01),the apoptosis rate was the highest in TDLN-Ⅲ group (39.1±1.5).Conclusion TDLN cells,having functions of aiti-tumor cells and inducing tumor cells to apoptosis,can be used as a new effective method to treat tumors.


We have constructed and operated a NMR polarimeter for high‐accuracy measurements of hydrogen and deuterium polarization in a frozen‐spin solid HD photonuclear physics target. The heart of this polarimeter is a pair of crossed (orthogonal) RF coils that form a transformer that responds only to precessing spins in the sample. We have performed a complete electronic circuit analysis of this crossed coil polarimeter (CC‐Meter), and have determined the optimum conditions for its operation. From this analysis, which is confirmed by NMR measurements on hydrogen and deuterium in solid HD, we conclude that the CC‐meter can be operated to give a very high signal‐to‐noise ratio (SNR) for thermal equilibrium polarization while also producing a highly linear response for fully polarized targets. In general, we find that a well‐designed and properly constructed CC‐Meter can provide a larger SNR at similar nonlinearity, compared to the more commonly used Q‐meter. We have used this polarimeter to produce H polarization measurements for a new, high precision determination of the GDH integral for the proton.


Background
 CCS1477 is a first in class potent, selective and orally bioavailable inhibitor of the bromodomains of p300 and CBP, two closely related histone acetyl transferases with oncogenic roles in haematological malignancies. In pre-clinical studies, CCS1477 was found to be a potent inhibitor of cell proliferation in acute myeloid leukaemia (AML) multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) cell lines. In primary patient AML blast cells CCS1477 inhibited proliferation through a combination of cell cycle arrest at the G1/S transition and an induction of differentiation (up-regulation of CD11b and CD86). CCS1477 has significant anti-tumour activity, inducing tumour regressions in xenograft models of AML and MM. These effects were accompanied by significant reductions in tumour MYC and IRF4 expression. Additionally, there are molecular features of certain haematological malignancies that are likely to increase the sensitivity to p300/CBP inhibition with CCS1477. For example, in B-cell lymphomas there are frequent loss of function mutations in CBP that are associated with heightened sensitivity to pre-clinical inhibition of corresponding non-mutated p300.
 CCS1477 represents a novel and differentiated approach to inhibiting cell proliferation and survival and offers a potential new therapeutic option for patients who have relapsed or are refractory to current standard of care therapies in AML, MM or NHL.
 Study Design and Methods
 This study is the first time that CCS1477 is being dosed in patients with haematological malignancies. The Phase I/IIa study aims to determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D) and schedule(s) of CCS1477 and investigate clinical activity of CCS1477 monotherapy in patients with haematological malignancies. This study will also characterise the pharmacokinetics (PK) of CCS1477 and explore potential biological activity by assessing pharmacodynamic and exploratory biomarkers.
 The trial aims to enrol approximately 90 patients and is currently recruiting in the UK with plans to open additional sites in the USA. Key inclusion criteria include patients with confirmed (per standard disease specific diagnostic criteria), relapsed or refractory haematological malignancies (AML, MM and NHL). Patients must have received standard therapy which for the majority of therapeutic indications is at least 2 prior lines of therapy. Single dose and steady state pharmacokinetics will be determined in all patients.
 AML response will be measured in bone marrow samples. Myeloma response will be evaluated according to the 'International Myeloma Working Group Response Criteria' based on changes in M protein in blood and/or urine, changes in serum free light chains if measurable, and changes on imaging and/or bone marrow if applicable and according to the guidelines. In NHL patients, tumour assessments will be done for measurable disease, non-measurable disease, and new lesions on CT (or magnetic resonance imaging [MRI]) and/or combined with visual assessment of [18F]2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) for response assessment per recent International Working Group consensus criteria (RECIL 2017), until progression
 The study will begin with two parallel monotherapy dose-escalation arms; Arm 1: Relapsed or refractory NHL and MM; Arm2: Relapsed or refractory AML/high-risk MDS. Once a recommended phase 2 dose/schedule is reached, three monotherapy expansion arms will be opened in AML/high-risk MDS (15 patients), MM (15 patients) and NHL (30 patients). Blood samples along with bone marrow biopsies and aspirates will be collected for exploratory biomarker analysis to understand mechanisms of response to treatment or disease progression. This will include the analysis of tumour-specific and circulating biomarkers, such as tumour DNA, mRNA, proteins or metabolites. In NHL patients, analysis of CBP (and p300) mutations will be undertaken to allow retrospective correlation with tumour response and to determine if loss of function mutations in the genes for either proteins can be utilised as response predictive biomarkers in future studies.

 Clegg: CellCentric Ltd: Employment, Equity Ownership. Brooks:CellCentric Ltd: Employment, Equity Ownership. Ashby:CellCentric Ltd: Employment, Equity Ownership. Pegg:CellCentric Ltd: Employment, Equity Ownership. West:CellCentric Ltd: Employment, Equity Ownership. Somervaille:Novartis: Consultancy. Knapper:Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Daiichi Sankyo: Honoraria; Jazz: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Tolero: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees. Davies:ADCT Therapeutics: Honoraria, Research Funding; MorphoSys AG: Honoraria, Membership on an entity's Board of Directors or advisory committees; BioInvent: Research Funding; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite Pharma: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bayer: Research Funding; Karyopharma: Membership on an entity's Board of Directors or advisory committees, Research Funding; Acerta Pharma: Honoraria, Research Funding; GSK: Research Funding; Pfizer: Honoraria, Research Funding; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Honoraria, Research Funding; Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding.


The relationship between viral infections, host immune responses, and long-term cardiac allograft outcomes is complex and not fully elucidated at this time.1 Children are exposed to many viruses, and young transplant recipients will often experience their primary infection for a given viral pathogen while under iatrogenic immunosuppression. Despite this, most viruses cause only mild clinical illness, and transplant recipients often clear infection in a fashion similar to that of their healthy (nonimmunocompromised) peers. Death or serious morbidity from acute viral infection, especially those caused by common respiratory and intestinal viruses, is very rare in children who have received heart transplants. Serious morbidity and mortality may, however, follow infection with human herpes viruses.

Article p 1798

Human herpes virus infections occur in most children during the course of childhood, and the viruses persist in the body indefinitely. Many primary infections carry no symptoms, and the presence of prior infection is identified through evidence of seroconversion at the time of evaluation for transplantation. Symptomatic disease is more common when primary viral infection occurs in the immunocompromised host. Primary Epstein–Barr virus infection posttransplantation poses significant risk for the development of posttransplantation lymphoproliferative disorders.2 Cytomegalovirus (CMV) may also cause severe infection, especially if primary infection occurs in the early weeks or months after transplantation. This risk appears low, however, in the modern era.3 Prevention commonly involves early postoperative use of intravenous ganciclovir and/or oral administration of valganciclovir, with or without immunoglobulin preparations. The length of therapy varies widely between centers. Pretransplantation seropositive status for …


Soft-sensing techniques in process control are reviewed. The methods of soft--sensor construction,the factors affecting performance of soft--sensors,on--line correction problems and their applications to industrial processes are discussed in detail. The future tendency of development is briefly presented.


Marriage and discipleship are major themes in this issue of Theology. The New Testament scholar and priest Stephen Barton offers a new and admirably clear article on 'Marriage and the Family'. A new contributor, Matthew Simpkins, offers a fresh critique of the Church of England's document Men and Women in Marriage, building upon Nigel Biggar's earlier critique (Theology 117/2), and particularly challenging Oliver O'Donovan's influence upon the document. Oliver, in turn, responds and then Matthew replies. I hope that this will encourage further and much-needed debate in this important area. Another new contributor, Mary McKenna, writes on 'New Directions in Mariology' and Stephen Cherry offers a thoughtful challenge to some recent uses of the concept of 'discipleship' within churches. Finally, Leslie Francis, together with Greg Smith, comments upon a Difficult Text on blindness ahead of Disability Sunday on 3 July. Three new and pleasingly compact books have caught my attention this time. Together they raise interesting issues for Christian ethics, the first two written by philosophers and the third by a Catholic theologian:


System for treating a tissue site with reduced pressure, apparatus, and methods, including a connector having a connector body. The connector body cavity, and including a cavity aperture. The connector also includes a conduit port for fluidly coupling the conduit to the cavity. Connector further includes a base adjacent to the cavity aperture configured to be positioned adjacent to the drape. Cavity is configured to be fluidly coupled to the manifold through the drape aperture. The connector also includes a sensing probe, the sensing probe has a distal end portion extending to the proximal end, and a cavity aperture configured to be fluidly coupled to the conduit. The distal end is configured to be positioned so adjacent to the manifold and in fluid communication. .FIELD 1


The use of internet technology is growing very fast which is driving the development of businesses in Indonesia, one of which is in the eCommerce sector. To support payment transactions conducted by e-commerce, in conducting this business, it is necessary to collaborate with business partner engaged in the payment gateways sector. Company partner engaged in the payment gateways sector to provide solutions to electronic financial transactions where one product is a credit card payment gateways. The purpose of this research is to make a risk assessment and risk management for audit certification credit card payment gateway Company. Risk assessment can help to know what are the risks that may occur, how big the impact of these risks, as well as recommendations related control measures must be carried out if the impact of these risks occur. This research using OCTAVE Allegro methodology to identify and evaluate information security risks credit card payment gateway. This research is qualitative research consisting of observation, conducting group discussion with the respondents. The respondend of this research are VP Development and Service Provisioning, VP Operation and Infrastructure, Manager Front End 1, Manager Back End 2, and Senior Programmer. Results of this research are 9 critical information assets in credit card payment gateway in COMPANY, such as : Card Holder Data & Customer Credential, Data Center, Physical Devices, Logical Storage, Logical Network, Supporting Software, Core Application, Encryption Key, and Human Resources. There are 21 risks that may occur during in credit card payment gateway. From 21 risks that were identified, obtained 15 risks are defer, 3 risks to be acceptable, and 3 risks should be mitigate.


This paper compares different methods for predicting the influence of residual stresses on brittle fracture. Comparison is made between fracture predictions of a local statistical approach based on the Beremin type model, with those of a well-known fracture assessment procedures, BS7910 and R6 that uses a failure assessment diagram (FAD). The results from both methods are discussed and compared. The study focuses on the behaviour of a ferritic steel pipe containing a partthrough circumferential thumb-nail crack on the outer surface of the vessel. INTRODUCTION One critical issue in the structural integrity assessment to be addressed is to characterise the influence of initial residual stresses on fracture. Predicting the effect of residual stresses is more important when the structure is likely to fail by brittle fracture. Tensile residual stresses may combine with in-service loads to promote failure. Determination of fracture parameters in residual stress fields has received great interest in recent years [1]. Local statistical approaches to predicting cleavage fracture toughness, mostly based on the Weibull distributions, have been developed [2-6]. Recently, a local stress based approach to fracture, developed by Hadidi-Moud et al [5] was applied to predict cleavage fracture probability in ferritic steels A533B and A508. The experimental data used for validation of the local approach were produced from standard laboratory test specimens [5]. Predictions obtained by application of the local approach for situations where the specimens were subjected to warm prestressing, WPS, prior to fracture loading at low temperature, exhibited very good agreement with the experimental data [5]. A significant feature of the developed model was the use of the same set of statistical parameters for the warm pre-stressed specimens as for the as received ones (i.e. with no prior load history) [5]. This was justified based on the fact that the model predictions were governed by the stresses within the plastic zone formed in the crack tip region. Since the prior loading history, WPS in this case, will change the stresses at a specified load when compared with the stresses corresponding to similar load in the as received conditions, it is anticipated that the stress field would automatically contain the prior load history effect and thus will account for its contribution to fracture. The concept was then further examined by application of the local approach to different types of load history. Initial residual stress fields were generated by either local compression, or in plane compression [7, 8] in laboratory sized samples. Application of the local approach to predict brittle fracture had consistent trends with experiments, although for some load history and or geometry configurations predictions did not completely accommodate the experimental findings [8]. The differences were addressed in the light of possible affecting parameters such as the micro-structural changes, crack tip blunting and change of constraint due to localised plastic deformation [7, 8, 9]. This paper further explores the implication of local approach in predicting the brittle fracture in presence of an


Assessment of the proximate composition and anti-nutrient composition of groundnut soup delicacy prepared with Ficus glumosa leaves was carried out in this study.  Proximate and anti-nutrient composition of all the soups namely groundnut soup made without Ficus glumosa (GS), groundnut soup made with unblanched F. glumosa (GSUB), groundnut soup with blanched F. glumosa (GSBF), with blanched and dried F. glumosa (GSBD) were evaluated using standard methods of the Association of Official Analytical Chemists (AOAC) and other standard assay techniques.  The results of the proximate analysis showed a high crude protein and crude fat contents (19.87 to 31.77 and 21.11 to 29.10  in percentage dry weight) respectively, in all the soup samples. GS had the highest protein content (31.77%).  The crude protein in all the soups were significantly (p<0.001) higher than GS. Also, crude protein in GSBD and GSBF had significantly (p<0.001) higher value compared to GSUB.  The crude fat of GSUB was significantly (p<0.05) higher than GS. The GSBD was also significantly higher (p<0.05) than GSUB. The soups had moderate carbohydrate (2.43 to 9.46%) and crude fibre content (0.23 to 5.37%). Ash content obtained was significantly (p<0.001) high in the F. glumosa containing soups and GS. Assessment of oxalate, phytate and tannin showed that cooking reduced the quantity of anti-nutrients in the soups.


Love on the Run ( L'amour en fuite, France, 1979 ) is Francois Truffaut's latest film featuring the fictional character of Antoine Doinel. By means of flashbacks from other films of the «Doinel series»,  the film goes over the protagonist's love mishaps. Picture with a Lady is a drama experiment applied to movie making, a fictional creation that makes its way through what was unrevealed in Love on the Run, and tells, in the folds of the unsaid, a love story imagined but already implied in the film. A love story both inevitable and impossible. KEYWORDS: Truffaut; Doinel; Amore; Montaggio;


International research consistently shows that high school disengagement is related to lower subsequent participation in paid work, fewer employment opportunities, and lower engagement in further education. In Australia, the number of people who do not complete high school varies from 16 to 26%, and the average fiscal and social/community costs of high school noncompletion are approximately $1 million per individual over a lifetime. High school exclusion is a key marker and potential driver of high school noncompletion. The overall objective of this chapter is to examine empirical literature on how complex adolescent behavioural risk and protective profiles impact on high school engagement and performance and to overview empirical approaches to systemic intervention and prevention. Understanding complex determinants will provide much better information on the timing and focus of policies and programs designed to support schools in improving education outcomes for at-risk adolescents. The chapter will make a series of evidence-based recommendations about the detection of students most at risk of exclusion and disengagement, and design features of programs most likely to work for at-risk youth.


The trap door flap is an excellent option for reconstruction of anterior pinna and conchal defects. It was first described by the senior author of this paper and it has been carried with excellent results on more than 50 patients in our institution. The flap is a simple one-stage procedure with very little donor site morbidity. Long-term aesthetic outcome is excellent with high patient satisfaction. We report on a modification of this procedure in order reconstruct a defect following excision of a lesion on the posterior aspect of the pinna.

A 90-year-old man was referred to the plastic surgery service with a lesion on the posterior aspect of his left pinna. It had grown significantly since he first noticed it 12 months before. The ulcerated lesion measured 2 cm in diameter (Fig. 1). Clinically, it resembled a squamous cell carcinoma clinically and there was no cervical lymphadenopathy. Under local anaesthetic the lesion was excised with a 4 mm margin and reconstructed with a trap door flap. In this case, we used a modification of the trap door flap to reconstruct the full thickness defect (Figs. 2, ,3,3, ,4).4). The lesion to be excised was marked out with a 4 mm margin. The post-auricular flap was drawn with a diameter equal to the lesion and its margin (Fig. 2). The posterior pinna lesion was excised with underlying cartilage along with skin from the anterior surface of the ear (Fig. 5). This left a full thickness circular defect of the pinna necessitating reconstruction. In the traditional trapdoor flap, the lesion is exised with underlying cartilage but the posterior pinna skin is preserved. A small circular posterior pinna incision is made to accommodate the flap. In our modified trapdoor, a uniform circular excision of cartilage and posterior and anterior pinna skin is made, thus creating a full-thickness defect of the pinna. The flap was subsequently raised and undermined leaving a centrally-based vascular pedicle (Fig. 3). The anterior portion of the flap was first inset to the most medial aspect of the defect so it was then possible to identify where the flap needed further mobilization. The posterior aspect of the flap was then sutured into the lateral aspect of the defect. A running absorbable suture was used inset the remainder of the flap (Fig. 4). The anterior aspect of the donor site is not closed as it is inaccessible when the flap is inset. There is actually no need to close the anterior part as the edges become relatively opposed when the flap is inset to the defect. The posterior aspect of the donor site is closed with a running absorbable suture and it is the only visible portion of the donor site in the post auricular area. Because the posterior aspect of the full-thickness defect is not covered by the flap, this area is sutured to the donor site. This can lead to the ear being pulled in slightly to the side of the head. However, patients do not seem to mind this mild asymmetry. Dressings were simple and consisted of Steristrips (3M, Maplewood, MN, USA) and Micropore brown tape (3M [Maplewood] and Micropore). The wound was reviewed seven days later at an outpatients clinic and the patient was also seen back at three months where the wound had settled down well (Fig. 5).

Fig. 1

The lesion on the posterior pinna with the post auricular trap door flap marked out.

Fig. 2

The circular full-thickness uniform defect of the pinna.

Fig. 3

The post auricular trap door flap raised and undermined leaving a small a central vascular pedicle.

Fig. 4

The trap door inset into the defect.

Fig. 5

The full thickness defect (shaded) is reconstructed with trapdoor flap based on a central pedicle. Photograph demonstrates the donor site three months postoperative.

Skin malignancies of the outer ear are extremely common and reconstruction can often yield poor results [1]. The trap door flap is a quick one-stage procedure which protects the natural contour of the ear thereby producing an excellent aesthetic outcome. To our knowledge, this is the first time that this modified trap door flap has been described to reconstruct a posterior pinna defect. The trap door flap was designed to treat lesions on the anterior pinna and concha only. It was originally described by the senior author [2,3] and it has been used successfully on over 50 patients to date. Posterior pinna defects are usually reconstructed with transposition flaps or full thickness skin grafts. However, the underlying cartilage is frequently taken when posterior pinna lesions are excised as the skin of the pinna is extremely thin. Reconstruction following cartilage excision can be difficult with contour deformities posing a potential problem. In this case, there was not enough redundant skin in the posterior auricular sulcus for a transposition flap.

Before now, the trap door flap has only been described for anterior pinna defects. It had to be modified slightly from the traditional trap door flap in order to reconstruct posterior pinna defects. The posterior auricular area blood supply has been well documented [4] and as a result flap loss is exceedingly rare [3].

McInerney et al. [3] reported on 45 patients with anterior pinna and conchal defects who had trap door reconstruction. They found the flap to be very reliable, producing a good cosmetic outcome. The flap provides a good colour match as it replicates the contour of the ear very well. We feel that the trap door flap should now be considered as a reconstructive option when excising skin malignancies on the posterior aspect of the pinna especially when there is a paucity of skin for a transposition flap. It is an extremely safe and effective flap with an excellent and predictable outcome.


Background This study investigated the feasibility of enhancing anaerobic digestion of sewage sludge with triple, dual, and individual pre-treatment of waste activated sludge with heat, alkalinity, and hydrogen peroxide. These pre-treatments disrupt sludge flocs, organisms' cell walls, extracellular polymeric substance, and intracellular organic matter, which increase biodegradability and hydrolysis rate of organic matter. In addition, the influence of various variables on methane production was analyzed using the response surface methodology with the quadratic model. Eventually, an optimized temperature and chemical concentration for the highest methane production and lowest chemical usage is suggested.Results The highest amount of methane production was obtained from the sludge pretreated with triple pretreatment (heat (90°C), alkalinity (pH=12), and hydrogen peroxide (30 mg H2O2 /g TS)), which had better performance with 96% higher than that of the control sample with Temperature of 25°C approximately and alkalinity of pH=8. Response surface methodology with the quadratic model was also used for analyzing the influence of temperature, pH, and hydrogen peroxide concentration on anaerobic digestion efficiency. It was revealed that the optimized temperature, pH, and hydrogen peroxide concentration for maximizing methane production and solubilisation of organic matter and minimizing thermal energy and chemical additives of the pre-treatments are 83.2°C, pH=10.6 and 34.8 mg H2O2 /g TS, respectively, has the desirability of 0.67.Conclusion This study reveals that triple pre-treatment of waste activated sludge performs better than dual and individual pre-treatment, Respectively. The enhanced methane production can be used as an important renewable energy resource in wastewater treatment plants for producing electrical and thermal energy. Furthermore, exploiting a higher amount of methane in the anaerobic digestion stage decreases methane emission to the atmosphere in dewatering and landfilling stages and enhances the quality of digested sludge, bringing about environmentally friendly and economically attractive sewage sludge treatment process.


Legislation that would alter class action practice in the federal courts has been pending in Congress. Nearly a decade's worth of U.S. Supreme Court cases have restricted the scope and ease of use of the class action device. Class action critics argue that class litigation is a "racket" that fails to compensate plaintiffs and instead enriches plaintiffs' lawyers at the expense of legitimate business practices.1 On the other hand, defenders of class actions decry the legislative and judicial forces aligned against them, warning that trends in class action law will eviscerate the practical rights held by consumers and workers.2 In short, there is considerable controversy over whether class actions are an economic menace or a boon to the little guys. Notwithstanding the fierceness of the class action debate and the apparent confidence of opponents and proponents in their factual assertions, there is a lot we do not know about federal court class actions, and we have no data that can be used to reliably determine whether class actions are good, bad, or some of each. In fact, we do not even know how many federal class actions there are.3 The absence of data on federal (and state) class actions, various explanations for the absence, and the import of this absence, were elaborated upon by one of us in another article not long ago.4


The article presents an analysis of the critical state of the U S on the eve of 2020 elections The current American predicament is described as a combination of several crises that have been accumulated over the years – social, political and the crisis of identity The social crisis is rooted in a glaring income inequality and downward social mobility, changing racial-ethnic composition of American society that raises the prospect of white minority, and a growing value gap between traditional and "progressive" post-materialist morale These cleavages result in political polarization in which increasingly secular/liberal, racially diverse, young and urbane Democratic Party confronts increasingly conservative, traditionalist, rural and white-nativist Republicans The U S political system designed for bipartisan consensus and compromise gets stalled in this polarized environment with the two-party configuration itself becoming a built-in destabilizer The political crisis was coupled with the crisis of traditional American identity based upon its WASP core This combustive combination created a fertile ground for a white nationalist revival attempt expressed in Donald Trump phenomenon Trump's formula of success as a president became a mix of traditional economic conservatism and right populist stance on social and cultural issues to cultivate his electoral base His policies aggravated social and political polarization: inoculated by right wing populism, the Republican party became more nativist and protectionist while the Democrats turned left Yet this formula worked out politically until the double crisis of 2020 – the Coronavirus pandemiс and mass protests over George Floyd's murder – struck the country Trump administration's inept response to the former and brutal treatment of the latter turned the bulk of the country against him The incipient left turn was accelerated while Trump exaggerated the threat of disorders positioning himself as a law-and-order president The Democratic party incorporated some of the protests' demands and worked out leftof-the-center election platform As a result, both sides diverged further to the point where neither would be likely to reconcile itself to its electoral defeat Though in the long run the prevalence of the liberal multiracial majority seems inevitable, the current polarization is likely to endure for a fairly long time © 2020, Russian Academy of Sciences All rights reserved


Whatever the discipline of engineering being studied a basic understanding of modern instrumentation systems and transducer selection is important. In particular this applies to engineering graduates entering the manufacturing sector where accurate information and speed of response is essential. In order to select appropriate transducers and their accompanying instrumentation systems, students must have confidence in solving practical measurement and control type problems. This paper discusses some of the main problems faced when teaching at undergraduate level and tries to address ways in which we may change our teaching by adopting case-studies and simulation software prior to analysing the system with mathematical rigour. (21 pages)


Radiation-induced soft errors have posed an increasing reliability challenge to combinational and sequential circuits in advanced CMOS technologies. Therefore, it is imperative to devise fast, accurate and scalable soft error rate (SER) estimation methods as part of cost-effective robust circuit design. This paper presents an efficient SER estimation framework for combinational and sequential circuits, which considers single-event transients (SETs) in combinational logic and multiple cell upsets (MCUs) in sequential elements. A novel top-down memoization algorithm is proposed to accelerate the propagation of SETs, and a general schematic and layout co-simulation approach is proposed to model the MCUs for redundant sequential storage structures. The feedback in sequential logic is analyzed with an efficient time frame expansion method. Experimental results on various ISCAS85 combinational benchmark circuits demonstrate that the proposed approach achieves up to 560.2X times speedup with less than 3% difference in terms of SER results compared with the baseline algorithm. The average runtime of the proposed framework on a variety of ISCAS89 benchmark circuits is 7.20s, and the runtime is 119.23s for the largest benchmark circuit with more than 3,000 flip-flops and 17,000 gates.


We have investigated the synthetic performance of the immobilized 3G3K mutant of the Penicillin G acylase (PGA) from E. coli obtained by site-directed mutagenesis. The 3G3K mutant, characterized by a tag consisting of three lysines alternating with three glycines at the end of the β-chain, has previously been reported to have a higher ratio for the rate of antibiotic synthesis and the rate of hydrolysis of the acylating agent (the vs/vh1 value) than the wild-type enzyme. New immobilization studies have been carried out with the 3G3K mutant by using different glyoxyl supports (activated with aldehyde groups). The catalytic properties of the new immobilized preparations were tested in the synthesis of Cefamandole and Cefonicid by kinetically controlled N-acylation (kcNa). Compared with the commercial wild-type PGA, the 3G3K acylase immobilized on glyoxyl agarose showed higher synthetic performance (reaction rates and yields) in all the tested reactions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)


We have tested the effect of protolichesterinic acid (PA) on the activity of the volume‐sensitive release pathway for the organic osmolyte taurine (VSOAC) and the expression of the leucine‐rich‐repeat‐channel 8A (LRRC8A) protein, which constitutes an essential VSOAC component. Exposing human lung cancer cells (A549) to PA (20 µg/mL, 24 h) reduces LRRC8A protein expression by 25% and taurine release following osmotic cell swelling (320 → 200 mOsm) by 60%. C75 (20 µg/mL, 24 h), a γ‐lactone with a C8 carbon fatty acid chain, reduces VSOAC activity by 30%, i.e. less than PA. Stearic acid (20 µg/mL, 24 h) has no effect on VSOAC. Hence, length of PA's fatty acid chain adds to γ‐lactone's inhibitory action. 5‐Lipoxygenase (5‐LO) activity is essential for swelling‐induced activation of VSOAC. PA has no effect on cellular concentration of leukotrienes (5‐HETE/LTB4) under hypotonic conditions, excluding that PA mediated inhibition of VSOAC involves 5‐LO inhibition. A549 cells exposed to the chemotherapeutic drug cisplatin (10 μM, 24 h) reveal signs of apoptosis, i.e. 25% reduction in cell viability as well as 1.3‐, 1.5‐ and 3.3‐fold increase in the expression of LRRC8A, Bax (regulator of apoptosis) and p21 (regulator of cell cycle progression), respectively. PA reduces cell viability by 30% but has no effect on p21/Bax expression. This excludes PA as a pro‐apoptotic drug in A549 cells. Copyright © 2015 John Wiley & Sons, Ltd.


Identifying early disease hallmarks in animal models with slow disease progression may expedite disease detection and assessment of treatment outcomes. Using optical coherence tomography (OCT), a widely applied non-invasive method for monitoring retinal structure changes, we analyzed retinal optical sections from six mouse lines with retinal degeneration caused by mutations in different disease-causing genes. While images from wild-type mice revealed four well-separated hyperreflective bands in the outer retina (designated as outer retina reflective bands, ORRB) at all ages, the second (ORRB2) and the third band (ORRB3) were merged in retinas of five mutant mouse lines at early ages, suggesting the pathological nature of this alteration. This ORRB change appeared to be degenerating photoreceptor-related, and occurred prior to obvious morphological changes that can be identified on both hematoxylin and eosin stained sections and electron microscopic sections. Importantly, the merging of the ORRB2 and ORRB3 was reversed with treatment of adeno-associated viral (AAV) vector mediated gene replacement therapies, and this restoration occurred much earlier than measurable functional or structural improvement. Our data suggest that the ORRB change could be a common hallmark of early retinal degeneration, and its restoration could be used for rapid and non-invasive assessment of therapeutic effects following gene therapy or other treatment interventions.


The morphological structure and interpenetrating property of ternary interpenetrating polymer networks of polyurethane/epoxy/poly(propylene glycol diacrylate)(PU/EP/PPGDA IPN)were stuied by IR,SEM and XPS.The results demonstrated that the distribution of components in IPN was inhomogeneous,and the inhomogeneity of IPN was closely related to the compatibility of component polymer and its morphological structure was also affected by the compostion of PU,EP and PPGDA in IPNs.


The monastic development of the Buddhist Architecture had attained an unparalleled height in the 8th century AD through the manifestation of the Sompur Mahavihara, presently known as Paharpur Buddha Vihara. The elaborate creative complex shaped by the local craftsmen from the very earth of Bangladesh remained little understood in terms of its form and morphology. The existing part of the dilapidated structure is deteriorating day by day being subjected to the causes both natural and man made. The structure, in its present form, poses with certain unexplained phenomena, which are worthy to investigate. The study, therefore, attempts to resolve those phenomena into a logical solution and create a basic understanding of the Form and Morphology of this particular organization. In this regard, a technical as well as an architectural perception will be given the utmost priority. An attempt of a conjectural restoration of the whole complex is the final outcome, based on the findings and on certain logical assumptions derived from the study.


THE EFFECT OF UTILIZATION CONTROLS ON HMO ENROLLEES' HEALTH, SATISFACTION WITH CARE, AND DISENROLLMENT Barbara Stewart Brown, Ph.D. Medical College of Virginia, Virginia Commonwealth University, 1987 Major Director: Louis F. Rossiter, Ph.D. The purpose of this prospective study is to examine the effects of differences in utilization controls on HMO enrollees' health, satisfaction with quality of care and access, and disenrollment. Previous studies of alternative care systems have shown that they are able to decrease costs (Luft, 1981; Anderson, Herald, Butler, Kohrman, & Morrison, 1985), but have not examined the organizational structure within the organization that oversees utilization. No prior studies have examined the effects of different types and degrees of utilization controls on the health, satisfaction, and access of enrollees. For this investigation, Williamson's (1975) theory of organizations, transaction costs economics, is used as the analytic framework. It is applicable to a study of utilization controls because it explains the organizational design or "governance structure" adopted to promote economic efficiency. Data for this study comes from the National Medicare Competition Evaluation's (NMCE) initial and follow-up beneficiary surveys and was merged with data about the plans. Data on the


Chapter 4 explores how another manifestation of Thurman's pragmatism—his Christian liberalism—was represented within the Fellowship Church and beyond. Chapter 4 takes a broader look at Thurman's activism within the scope of the midcentury Christian Left and examines how the characteristic cosmopolitanism and Christian liberalism of the movement thrived within the institution. The chapter also expands on how the Fellowship Church's values transcended its walls through connections to a dynamic international community of religious liberals as well as through a thriving liberal religious middlebrow book culture via Thurman's 1949 book, Jesus and the Disinherited. Overall, this chapter emphasizes the timeliness of the Fellowship Church and sheds light on the expressions of religious nonviolence that took shape in the mid-twentieth century.


Extract: To determine the influence of human growth hormone (hGH) on gall bladder bile composition, bile (concentration and molar percentage of cholesterol, bile acids, and phospholipids) was examined in three growth hormone-deficient patients and in one control subject with constitutional short statute, but with adequate secretion of growth hormone. Investigations were made before and after 0.3, 4, and 12 months of therapy with exogenous hGH, 3 U/week. Two patients responded to hGH with accelerated growth (increase in height velocity from 1.3 and 0.2 cm/year to 10.5 and 3.0 cm/year, respectively), but, during the same time, the cholesterol concentration in bile increased progressively, raising the "lithogenic index" from 1.00 and 0.93 to 1.66 and 1.10, respectively. Normally, the "lithogenic index" is 1.00 or less. The third patient also showed some growth acceleration, but his bile did not become oversaturated with cholesterol. The bile of the control subject was excessively saturated with cholesterol after 0.3 months of treatment with hGH, raising the "lithogenic index" from 0.10 to 2.94, the highest yet reported in man. However, this abnormal response to hGH was not sustained, and bile composition returned to normal later on. The data obtained in this study suggest, but do not prove, that hGH might influence cholesterol secretion into bile.Speculation: Normally, biliary cholesterol is kept in micellar solution by bile acids and phospholipids. An increase in the concentration of cholesterol in bile, without a concomitant increase of bile acids and/or phospholipids, causes oversaturation of bile with cholesterol, as expressed in changes of the lithogenic index. The lithogenic index is a quantitative expression of the cholesterol saturation in bile by a single figure which represents all three major biliary lipids. Oversaturation of bile with cholesterol is now recognized as a probable prerequisite for the formation of cholesterol gall stones. Further studies should now define the influence of hGH on biliary cholesterol secretion rates.


Job interviews are one of the most common methods of selecting employees. However, most people experience a certain amount of anxiety during a job interview. This study aims to help people overcome this anxiety by using a virtual reality job-interview simulation system. This system utilizes voice recognition, a dialogue knowledge base, and morphological analysis to generate new questions that include nouns from the user's answers. We expect the user's sense of presence and anxiety to increase with interactive questions. This research used self-assessment questionnaires and psychophysiological measures to investigate two study conditions: (a) using developing questions that included part of the user's answer (n = 10) and (b) using a fixed developing question (n = 10). The results suggested that using developing questions that included the user's answer provided a greater sense of presence and anxiety.


The content of amino acids of Bacillus subtilis,Bacillus natto and microorganism compounds had been analyzed by HPLC,and which was 53.2g/100g,56.4g/100g,59.5g/100g.Carps were fed with basal diet supplemented 0.1%,0.2%,0.5% Bacillus subtilis,Bacillus natto and microorganism compounds for 45 days.The activities of protease and amylase in the intestine and hepatopancreas of carps were determined.The results indicated that activities of protease in the intestine fed with dietary 0.1%~0.5% Bacillus natto,the activities of protease in the hepatopancreas fed with dietary 0.1%~0.2% Bacillus natto and the activities of amylase in the intestine and hepatopancreas fed with dietary 0.1% Bacillus natto were higher respectively than those of the control group.The activities of protease and amylase in the intestine of carps fed with dietary 0.1%~0.5% Bacillus subtilis were higher respectively than those of the control group.But the activities of protease and amylase in the hepatopancreas of carps fed with dietary 0.1%~0.5% Bacillus subtilis were the same of those of the control group.The results also showed that the activities of protease and amylase in the intestine and hepatopancreas of carps fed with dietary 0.1%~0.5% microorganism compounds were much higher respectively than those of the control group,Bacillus subtilis group and Bacillus natto group.So the microorganism compounds was a kind of good feed additive,the best dietary dose was 0.1%~0.2%.


Taking the clay with high liquid limit as an object, key technologies such as the technical characteristics, treatment methods and construction techniques are studied. The research results can guide the application of the construction technology of clay subgrade with high liquid limit effectively, and play an important role in the practical project.


Financial crisis had profound impact on the development of Chinese small medium - sized chemical industry. The effects on the professional practice of Chemical Technology in this background were analyzed.The counter-measures were gived to solve these problems.These were of certain guiding significance for the post practices of the other specialties in our college.


A disk drive includes a light source configured to transmit information indicative of an optical disc drive state. A disk drive for a disk drive system further comprises a light guide and a second light pipe a first light pipe, said first light pipe is configured and dimensioned to mechanically coupled to the disk drive and is configured to receive and guide light directly emitting light; a light pipe and the second pipe separating the first light, the second light pipe is configured to receiving from said first light pipe and directing light from the first light pipe to the user-visible state of the lens.


SEBASTIAO-FRANCO, B.A. Efficacy assessment of physical exercises protocol based on the Pilates method for the variables lumbar pain, flexibility and muscular strength in a group of nursing porfessionals with chronic idiopathic low back pain. 2010. 183 p. Thesis (Doctorate) University of Sao Paulo Ribeirao Preto Nursing School, Ribeirao Preto, 2010. Researchers from many countries have pointed nursing professionals as a risk group to osteomuscular disorders, with emphasis to lombalgy as one of the factors associated to impairment in the execution of laboral activities. Among the physical exercises indicated in these cases those based on the Pilates method stand out for the capability of activating neuromuscular control mechanisms, effectiveness to relieve pain and improvement of functioning of individuals with non-specific chronic low back pain. The hypothesis tested in the present study is that physical exercises based on the Pilates method are more effectivein the treatment of low back pain when compared to conventional stretching and strengthening exercises. The objetive of the present study was to compare the effectiveness of a physical exercises protocol based on the Pilates method, considering the variables low back pain, cervical spine, trunk and hips flexibility and gluteous strength, to another with conventional stretching and strengthening exercises in a group of nursing professionals with chronic idiopathic low back pain. It is a controlled non-randomized study with quantitative data analysis in which 19 nursing professionals participated (nurses, technicians and auxiliary nurses) from a university hospital in Sao Paulo state, Brazil. Data collection was conducted between September 2009 and June 2010 through application of three instruments (preassessment, personal data form and Oswestry questionnaire) and two physical tests (fleximetry and dynamometry). Participants were divided in two groups: a control group (CG), which was submitted to a conventional stretching and strengthening physical exercises protocol, and the Pilates Group (PG), submitted to the physical exercises protocol based on the Pilates method. Data was analyses through softwares Statistical Package for the Social Science (SPSS), version 15.0 for Windows and statistical Analysis System (SAS), version 9. Physical exercises based on the Pilates Method obtained significant efficacy in the improvement of strength of right and left gluteous maximus (p < 0,01 e p = 0,04, respectively). In an intragroup analysis, CG present a significant improvement of trunk amplitude (Cs= 0,91 p < 0,01), when compared to PG after intervention. Concerning low back pain, both protocols presented clinical improvement. The Pilates method shows superior efficacy in the improvement of gluteous strength when compared to conventional exercises. Conclusion: The Pilates Method presents motivating aspects when compared to conventional exercises, besides particularities, such as number of repetitions, work the body as a whole and principles which sholud be applied during the execution of the method, which determine corporal discipline and consciousness. This could provide a greater adhesion to physical activities offered to nursing professionals during work time.


The development of Open Path FTIR for use in industrial setting has necessitated techniques for obtaining valid background spectra. Measurements over extended path lengths have resulted in greater problems with handling atmospheric moisture correction. Some industrial environments may even have almost continuous levels of chemical species present. Background correction techniques to address these problems employing a near-field source, a fixed reference, or a 'rolling' reference are presented and compared. Field experience obtained at several major plant sites over a year and a half of operation is reviewed.


This paper seeks to expand on environmental design understood in purely instrumentalist terms. It argues that current environmental emergencies in Australia and elsewhere are requiring alternative strategies of response, and proposes the terrain of poetic work as offering new insights in the field of sustainability practice. It draws upon two place-making projects to advance a theory of environmental design that is poetically guided.


Patanjali Ayurveda Limited is a successful Indian FMCG company headquartered in Haridwar, Uttarakhand, India. There are many factors that make the success story of Patanjali Ayurveda Ltd. The brand ambassador Yoga Guru Baba Ramdev, the Company's swadeshi concept, its product quality and fair price offered by the company, and easy availability of the products in the market are a few of these factors. Patanjali Ayurveda Limited deals in various products segments like food products, Health care Products, and Personal Care Products. The present study has emphasized the perception and preferences of women consumers of Patanjali Ayurveda Limited towards its personal care products. The purpose of the present study is to examine the preferences and perceptions of women regarding the personal care products of Patanjali Ayurveda Limited. This paper will also attempt to investigate the women's awareness level and also identify the factors which motivate a woman to purchase the personal care products of Patanjali over other brands. This study is empirical in nature and data is collected through questionnaire method by visiting Patanjali Stores in Haridwar district of Uttarakhand.


The purpose of Test K-4-13 detailed in this report was to evaluate the behavior of N Reactor fuel elements at conditions equivalent to or more severe than those expected in N Reactor during Phase I) equilibrium operation. Specific objectives of Test K-4-13 were: Measurement of fuel distortion and swelling; Evaluation of irradiation damage to the jacket uranium bond and to the uranium core; and Evaluation of the performance of the fuel element support system.


Papaverine hydrochloride induces c-tumours in root tips of Allium cepa. Two types of enlargements were noticed, complete swelling along the majority of the root and complete swelling with a certain enlargement immediately after the 2 mm terminal tips. The histological examination of these zones revealed that these swelling were due to cell enlargement both in meristematic and in tumour zones. This conclusion was evidenced from the result obtained of the nucleoplasmic index.Papaverine hydrochloride and morphine sulphate showed roughly polyploid roots as the concentration of the chemical increased. The effect of cannabis dissolved in water on the rate of polyploid induction varied according to the concentration applied.


In North America there are significant similarities and differences in attitudes with regard to alcohol and tobacco on several dimensions, including the view taken of producers, suppliers and retailers, the products, and in the patterns of use. There are also contrasting as well as overlapping tendencies with regard to perceived problems associated with alcohol versus tobacco consumption, intervention initiatives and the resources available. These secular developments and forces provide a context for examining 10 community-based prevention trials which have sought to reduce harm from alcohol or tobacco using a range of strategies. The strategies have included education and information campaigns, media advocacy, counter-advertising and health promotion, controls on selling and consumption venues and other regulations reduced access to alcohol or tobacco, enhanced law enforcement and surveillance, and community organizing and coalition development. The paper outlines the challenges of undertaking community-based trials and interpreting their findings. It notes that interventions which show promise are those that pay particular attention to controls on access, include the environmental contexts of where the products are sold and distributed, and involve enforcement of public health polices. Controlling tobacco use may be made somewhat easier, than is the case for alcohol, with the vilification of the tobacco industry and marginalization and victimization of smokers. Nevertheless, the community trial provides opportunities for reducing harm related to alcohol and tobacco, particularly if resources are oriented in a coordinated way to those control measures and policies with the widest scope and greatest effectiveness.


One essential factor when developing a project based learning (PBL) program is giving the required resources leading the student's learning process. We want our students do their own research and obtain the proposed competences, but reaching this objective require a proper project definition, giving appropriate resources and information access. Small questions are also usually proposed for a better project orientation. On a first stage, we are focusing our efforts on augmented project definitions for chemistry practices (density and viscosity) for higher maritime students. Augmented reality can be used for accessing to virtual materials even when outside the laboratory. These mainly consist on 3D models of objects and devices used for measuring, manipulate or processing, and video contents explaining related concepts and other relevant information. Students can study and manipulate fragile and expensive stuff, like viscometers through their mobile device, and watch video demonstrations with another device when working in small groups, while a third student annotates concepts, ideas and procedures on a virtual shared mental map. Augmented materials will be used in a mobile collaborative environment, so mobile devices like smartphones tablets and iPads are a key factor for a better and a more engaging experience for our students. Visualizing augmented contents on virtually any mobile device will be possible by the use of Junaio as it runs on iOS and Android, so we have decided to use Metaio Creator and export as AREL packages to a Metaio server. At the end of these experiences, we expect to obtain better grading results compared with other learning methods. © 2013 The Authors. Published by Elsevier B.V. Selection and/or peer-review under responsibility of the programme committee of the 2013 International Conference on Virtual and Augmented Reality in Education.


The importance of teacher talk in Arabic-speaking learning is not only as a medium to organize the class and train the students. However, also a source of language acquisition and a means for achieving learning objectives. This research aims to: 1) explore the type of teacher talk modes in Arabic Speaking learning, 2) explore the most dominant type of teacher talk modes that occurs in Arabic Speaking learning. The researcher used a qualitative approach, and the type of this research is a case study. The methods of data collection are observation and interview. The results of this study indicate that: 1) All four types of teacher talk modes in the SETT framework (Managerial mode, Material mode, Skills and Systems mode and Classroom Context mode) occur in Arabic Speaking learning, and 2) The Managerial Mode is the most dominant type of teacher talk mode that occurs in Arabic-speaking.


In this paper, an online signature verification scheme based on spectrum analysis and Mahalanobis decision is proposed. We firstly divided signatures to a number of frames with variable widths according to the characteristics of the time sequences, and then employed the fast Fourier transformation (FFT) to extract the spectrum of signatures. The distance between the Fourier coefficient within the corresponding frames is computed, and the Mahalanobis decision making is employed. Experimentation demonstrates that spectrum analysis based on windows with variable widths is effective for online signature signals


Objective To evaluate the clinical efficacy of direct percutaneous coronary intervention (PCI) and thrombolytic therapy aged patients with acute myocardial infarction(AMI).Methods Sixty-five aged patients(age≥60 years old) with AMl were divided into direct PCI treatment group (n=31) and thrombolytic therapy group (n=34).The clinical outcomes between the two group were compared.Results The infarct-related artery (IRA) reperfusion rate in the patients with intravenous thrombolysis was 58.8%;While in the PCI group the IRA reperfusion rate was 96.8%.There was significant differences in left ventricular ejection farction (LVEF) in six months after AMI between thrombolytic group and the PCI geroup(40.2%±6.3% vs 53.8%±6.7%,P0.05).The ratio was higher in thrombelytic group than in PCI group among complicated hemorrhage rate.The average days staying inhospital was less in the PCI group than in the thrombolytic group.Conclusion Direct emergency PCI in elder oatuebts with AMI could rapidly and efficaeiously reperfuse IRA,rescue dying myoeardium,improve left ventrieular function,and reduce the mortality of AMI in the aged patients.


The author criticizes the argument in Dyzenhaus (1991) that a study of South African judicial decisions establishes the superiority of Dworkinian anti-positivism over legal positivism. Among the claims criticized are: (1) Positivism and anti-positivism each imply a specific theory of judicial duty, and the decisions of South African judges are explained by their adherence to one or the other of these theories; (2) resistance to South African government policy was morally required of judges; (3) the only theory which supports this resistance (anti-positivism) is therefore the correct one; (4) the cases establish that judges do not have discretion in hard cases; (5) Dworkin's theory does not imply that South African judges are required to apply the wicked principles embedded in their legal system; (6) positivism involves a pragmatic contradiction.


As a special group,impoverished college students' survival and developmental is related to social harmony.The accumulation of social capital of these students is an important part of education.They need to develop the awareness and the methods of the accumulation of their social capital through varieties of ways,involving the boost in their initiative in exploiting resources among schoolmates,active participation in social activities,and the nurture of their own virtue.


During the new period,the young rural people are greatly changing their conceptions;especially the young rural people of south area in Jiangsu province,and these changes have not only good aspects but also bad ones. Referring to this,we must propose more exigent and higher demands on political and moral education work of the young rural people during the new period. Therefore,at this special time,we should strengthen the education on their beliefs,democratic and legal system,science and culture,and also the market awareness,etc. Meanwhile,we still must pay attention to use some reasonable and appropriate ways on education.


In 1977, with Hu, Lan Cheng and Zhu, His Ning's leading and enlightenment, a group of young intellectuals founded the "San San Literary Periodical." The collected papers were filled with traditional oriental intellectual's styles. Besides, various kinds of discourses from literature to social problems were all included. This publication was not only the land for literary creations but also the land for the elaboration of the theory of Hu, Lan Cheng-their spiritual mentor.Once the saying, "Every one of the San San Literary Group has to be an oriental intellectual." was brought up in the meeting of San San Literary Group, which intended to become a three-thousand-intellectual literary group.The reasons why all the members of this group in the 70's Taiwan have to be the oriental intellectuals, especially in such an occidentalizing society at that time, and the distinction between the intellectuals in the east and the west are going to be discussed in this article. Furthermore, a contending is found in the comparison between the definitions to the oriental intellectual in the San San Literary Periodical and the theories related to this topic in the west. This article is going to look deep into the conflict and try to find out what the two sides insisted on.


We point out in this paper that the heavy Fermion system is a kind of Kondo system whose localized f-electrons can change with temperature. The theory suggests the existence of spontaneous magnetic moment in particular temperature range. According to the different distance between the f-electron band and Fermi level, there are different types of spontaneous magnetic moment effect. We also point out that the anomaly in specific heat versus temperature-curve is caused by the change of number of f-electron in heavy Fermion system. The theoretical values of specific heat coincide well with six experimental data.


The paper describes the decision making and learning strategies for determining tools and cutting conditions of an automatic decision-making and learning system embedded in the intelligent CNC system/workstation of machining centers (ADLS-CNC). The functions of the system include: selecting the correct cutting tool, determining the optimal size and number of cuts, specifying machining parameters (speed and feed) for each cut and adapting them to a specific workshop environment from learning on-line.


In 1974, the National Capital Development Commission in Canberra, Australia announced a formal shift in emphasis in transport planning, designed primarily to support long term development of more effective local and intertown public transport, to be fostered in part by measures to discourage use of private cars for commuting to work. Consultants were appointed to develop a transport plan for the period from the mid 1970's to the early 1980's for the management of the transport system in a manner designed to foster a smooth transition to a higher level of transit dependence when major new transport facilities are available in the 1980's, the questions for planning and evaluation posed by the new policy approach called for the development of policy sensitive models and the study relied heavily on the use of disaggregate travel demand models to handle questions for which traditional four step modelling techniques are unsuitable. A parallel program of public participation was undertaken by the National Capital Development Commission to test public acceptability of proposed measures. (A)


Aiming at the problems of low grinding efficiency and difficulty in ensuring grinding uniformity of rare earth metal ingots, a rare earth metal ingot grinding system was designed. Based on Creo software and ANSYS/Workbench software, the kinematics analysis, modal analysis and transient dynamics analysis were carried out on the walking mechanism and flipping mechanism of automatic displacement platform of grinding system. The results show that the rare earth metal ingot grinding system has good stability and is beneficial to improving the grinding quality.