It is necessary to strengthen the research of executive capacity while carrying out the strategy of Intelligence-Led Policing with Chinese features.After the analysis to ILP situation in some western developed countries and China,the paper points out the main problems and reasons in the field of executive capacity and stresses ten kinds of capacities which the ILP executive should possess and the crucial method to improve ILP executive capacity.


The urban and territorial planning in Mexico started late, and always federal, state and local governments haven't been able to forecast the long term issu...


With the fragmentation of electronic markets, exchanges are now competing in order to attract trading activity on their platform. Consequently, they developed several regulatory tools to control liquidity provision / consumption on their liquidity pool. In this paper, we study the problem of an exchange using incentives in order to increase market liquidity. We model the limit order book as the solution of a stochastic partial differential equation (SPDE) as in [12]. The incentives proposed to the market participants are functions of the time and the distance of their limit order to the mid-price. We formulate the control problem of the exchange who wishes to modify the shape of the order book by increasing the volume at specific limits. Due to the particular nature of the SPDE control problem, we are able to characterize the solution with a classic Feynman-Kac representation theorem. Moreover, when studying the asymptotic behavior of the solution, a specific penalty function enables the exchange to obtain closed-form incentives at each limit of the order book. We study numerically the form of the incentives and their impact on the shape of the order book, and analyze the sensitivity of the incentives to the market parameters.


Abstract
Extending the argument made in Bushe and Marshak (2009) of the emergence of a new species of Organization Development (OD) that we label Dialogic, to differentiate it from the foundational Diagnostic form, we argue that how any OD method is used in practice will be depend on the mindset of the practitioner. Six variants of Dialogic OD practice are reviewed and compared to aid in identification of a Weberian ideal-type Dialogic Mindset, consisting of eight premises that distinguish it from the foundational Diagnostic Mindset. Three core change processes that underlie all successful Dialogic OD processes are proposed, and suggestions for future research offered.


plete study, the Tibetan Plateau has for nearly 150 years figured prominently in the development of basic concepts of how the Earth behaves and evolves. The most profound idea of tectonics, isostasy, was born in the last century, when Pratt (1855) recognized a deficit of mass beneath the Himalaya and Tibet, and Airy (1855) quickly inferred that thick crust beneath the plateau buoyed it up. (Ironically, because explorers and trade routes had avoided the plateau, Pratt's maps underestimated, by nearly two times, the extent of the plateau and the degree to which mass was missing.) Later in the 19th century and early 20th century, explorers like Hedin (Hennig 1915), Littledale (1896), and Norin (1946), made observations that still provide the basis of our present-day geologic knowledge of Tibet – e.g. observations of Cretaceous limestone, which require that much of the plateau was at sea level at that time, or of scattered fresh volcanic rock and active volcanoes in north Tibet, implying a partially molten uppermost mantle. Precociously integrating the sparse observations of active and recent tectonics with the then new idea of continental drift, Argand (1924; Argand and Carozzi 1977) built a scenario of continental collision around the underthrusting of India beneath Tibet. In a comparably modern interpretation, largely of their own field data, Heim and Gansser (1939; Gansser 1964) recognized the simplicity of India's underthrusting beneath southern Tibet and the construction of the Himalaya by the off-scraping of slices of India's northern margin; the Himalaya became the prototype of a collision zone between two continents. Still relying on the observations of early explorers, Dewey and Burke (1973) ushered in the present-day focus on Tibet by pointing out that Tibet serves as the contemporary analogue for many ancient terrains where deformation had been widespread and magmatism had played a key role. Then with remote sensing using seismic waves from earthquakes and Landsat imagery, it became clear that the plateau is actively collapsing (e.g. Molnar and Tapponnier 1975, 1978; Ni and York 1978). The style of deformation that built the plateau has changed completely. Moreover, it had become obvious that plate tectonics, which demonstrated that large areas move laterally over the surface of the Earth as rigid plates, in fact, provided little guidance for understanding mountain building. Tibet became the prototype for both the growth and the demise of mountain belts. (The processes that are now destroying the plateau have shaped the Basin and Range Privince of western North America, e.g. Coney and Harms, 1984; Molnar and Chen 1983) Tibet's significance is not limited to tectonics and mountain building; using newly developed General Circulation Models of the atmosphere, Hahn and Manabe (1975) suggested that the uplift of Tibet played a key role in the development of the Indian monsoon. Tibet serves as both an obstacle to atmospheric circulation and as a possible heat source to the atmospheric boundary layer. As such, it perturbs the general west to east flow of the atmosphere at mid-latitudes and contributes to the large standing waves that characterize circulation in the northern hemisphere (e.g. Manabe and Terpstra 1974; Held 1983). This was later extended to suggest that the rise of Tibet and the Himalaya contributed to late Cenozoic climate changes (e.g. Raymo and Ruddiman 1992; Ruddiman and Kutzbach 1989). The possibility that Tibet plays a key role in the monsoon was given a boost when Harrison et al. (1992) proposed that Tibet rose abruptly


Background Although there is strong evidence linking triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to insulin resistance and diabetes mellitus, its clinical importance in pregnant women has not been well determined. This study sought to determine the connection between the TG/HDL-C ratio in the first trimester and the eventual onset of gestational diabetes mellitus (GDM). Methods We performed a secondary analysis of open-access data from a prospective cohort study. This present study included 590 singleton pregnant women at 10-14 weeks who visited the outpatient clinics for prenatal checks and were recorded at Incheon Seoul Women's Hospital and Seoul Metropolitan Government Seoul National University Boramae Medical Center in Korea. A binary logistic regression model, a series of sensitivity analyses, and subgroup analysis were used to examine the relationship between TG/HDL-C ratio and incident GDM. A receiver operating characteristic (ROC) analysis was also conducted to assess the ability of the TG/HDL-C ratio to predict GDM. Results The mean age of the included individuals was 32.06 ± 3.80 years old. The mean TG/HDL-C ratio was 1.96 ± 1.09. The incidence rate of GDM was 6.27%. After adjustment for potentially confounding variables, TG/HDL-C ratio was positively associated with incident GDM (OR=1.77, 95%CI: 1.32-2.38, P=0.0001). Sensitivity analyses and subgroup analysis demonstrated the validity of the relationship between the TG/HDL-C ratio and GDM. The TG/HDL-C ratio was a good predictor of GDM, with an area under the ROC curve of 0.7863 (95% CI: 0.7090-0.8637). The optimal TG/HDL-C ratio cut-off value for detecting GDM was 2.2684, with a sensitivity of 72.97% and specificity of 75.05%. Conclusion Our results demonstrate that the elevated TG/HDL-C ratio is related to incident GDM. The TG/HDL-C ratio at 10-14 weeks could help identify pregnant women at risk for GDM and may make it possible for them to receive early and effective treatment to improve their prognosis.


In the past hypoglycaemia has been a source of some worry for paediatric anaesthetists as it was widely accepted to be a potential danger for infants and children during the peri-operative period. The routine use of glucose containing intravenous solutions was recommended to avoid this (Payne & Ireland, 1984). Recent studies have encouraged a more liberal approach to pre-operative oral fluids (Goresky & Maltby 1990), and it is now considered that, apart from small infants, the danger of hypoglycaemia should be remote, though it may very rarely occur in the older child (Long 1989). More recently attention has focused on the previously less well recognized hazards of hyperglycaemia. It has become apparent that commonly used fluid administration regimes, together with the effects of the physiological response to the stress of anaesthesia and surgery, may result in many patients becoming progressively hyperglycaemic over the peri-operative period (Nilsson et aZ. 1984). The routine use of solutions containing 5% dextrose commonly provides more dextrose than can be utilized by the anaesthetized patient. Hyperglycaemia is undoubtedly dangerous to some patients. The small preterm infant with immature renal tubular function has been recognized to be at risk of severe dehydration and electrolyte disturbance as a result of a glucose induced diuresis (Fox & Krasna 1973). In recent years, however, the possible effect of hyperglycaemia on neurological damage following a cerebral ischaemic-hypoxic episode has become a major concern. This danger has been demonstrated by clinical studies which established that diabetic patients with poorly controIled blood glucose levels had a worse outcome following a stroke (Pulsinelli et a2. 1980). Furthermore patients who had higher blood glucose levels on admission to hospitaI made less complete neurological recovery following out-of-hospital cardiac arrest (Longstreth & Inui 1984). In infants and children the possible association of transient postoperative neurological deficits following cardiac surgery under profoundly hypothermic circulatory arrest with high intra-operative blood glucose levels has been reported (Steward, DaSilva & Flegell988). The possibility that an unexpected severe neuroIogicaI injury folIowing resuscitation from a short ischaemic episode might be associated with dextrose administration has also been suggested (Berry 1990). The proposed mechanism of increased cerebral injury is as follows. During hyperglycaemia brain glucose concentrations increase. If hypoxia or ischaemia then occurs the resulting anaerobic metabolism of this increased brain glucose content to lactic acid will result in ahrger acid load and more extensive cellular injury. Experimental animal studies have produced similar findings and have demonstrated some of the mechanisms that may be involved. Primate studies showed that dextrose infusion during resuscitation following cerebral ischaemia increases mortality and morbidity even if the blood glucose level does not rise significantly (Lanier et aI. 1987). This is suggested to be due to the fact that blood glucose levels underestimate the increase in brain glucose content which occurs with dextrose infusion; there is facilitated diffusion into normal brain tissue, and cerebral injury may compromise the blood-brain barrier. Other biochemical mechanisms may also be involved in the production of increased cerebral damage. The level of adenosine in the cerebral cortical extracellular space has been noted to be lower in hyperglycaemic than normoglycaemic animals following a period of cerebral hypoxia. Adenosine is a recognized cerebroprotectiie agent (Phillis, Simpson & Walter 1990). There seems to be no doubt that hyperglycaemia has the potential to increase the extent of neurological damage following a hypoxic-ischaemic event in most of our patients. It is not yet quite clear whether this is also true in the immediate newborn period. Experimental studies in immature animals suggest that the danger may not be so great. Glucose administration did not accentuate hypoxicischaemic damage in immature animals (Vannucci, Vasta & Vannucci 1987) and brain lactate levels were


With a purpose to looking for the possibility of using bone char for remediation of contaminated soils,experiment was conducted to study Pb2+ adsorbed onto bone char in terms of sorption isotherms and adsorption dynamics,as well as effects of pH and ionic strength. The experiment was done using two kinds of bone char (Zhejiang and England)and the result showed that the sorption isotherms fitted well with Langmuir equation and pH and ionic strength had no significant effects on the adsorption ability. Besides,Pb2+ adsorption could maintain unchanged when As(100 mg/g)and Cd(200mg/g)co-existed. It was concluded that lead adsorption on bone char was involved with a sort of complicated heterogeneous solid-liquid reaction.


A growing number of children and adolescents are experiencing and surviving cancer. This review aims to identify the demographic, medical, and psychosocial correlates of perceived post‐traumatic growth in individuals of any age who were affected by paediatric cancer. Findings will highlight protective factors that may facilitate post‐traumatic growth, allowing for directed social support, intervention, and follow‐up care.


In this study, ethyl 7-hydroxy-6-chloro-4-methylcoumarin-3-propanoate (1), ethyl 7-(2,3-dicyanophenoxy)-6-chloro-4-methylcoumarin-3-propanoate (2), ethyl 7-(3,4-dicyanophenoxy)-6-chloro-4-methylcoumarin-3-propanoate (3), ethyl 4-chloro-5-(7-oxy-6-chloro-4-methylcoumarin-3-propanoate)phthalonitrile (4) were synthesized. The phthalonitrile derivatives (2, 3 and 4) were converted to their peripheral tetra, non-peripheral tetra and peripheral chlorocta substituted zinc(II) and chloroindium phthalocyanine derivatives. All novel compounds were characterized by elemental analysis, FT-IR, 1H-NMR, MALDI-TOF mass spectrometry and UV-vis spectral data. Additionally, the spectral, photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen generation and photodegradation under light irradiation) properties of the resulting substituted phthalocyaninatozinc(II) and indium(III) chloride complexes (5–10) were investigated in DMF, and the obtained results were compared for determination of ...


The phenomenon of noise interference during vocal transmission can lead to the problem of poor vocal transmission quality. This paper proposes a study on the sustainability of vocal ecology in a digital ecological environment. First, the matching tracking algorithm can extract the time-frequency characteristics of the effective signal, attenuate the interference of noise, and improve the propagation quality. A sustainable development GA-BP network model is established, and the adjustment amount of each weighting coefficient is obtained according to the gradient algorithm and using the inertia adjustment strategy. The coordination is regulated through feedback control strategies to ultimately achieve ecological sustainability of vocal music. The analysis results show that the average relative error of the simulation prediction of the sustainable development GA-BP network model is 3.54%, the maximum relative error is 8.11%, and the average relative error is within 5% of 70%. It has significant superiority and high efficiency in comparison with the prediction degree of the traditional model.


Ectopia cordis is a rare congenital defect commonly associated with intra- and extra-cardiac anomalies. This report highlights the complimentary use of echocardiography and cardiac magnetic resonance imaging for detailed prenatal characterization of the anomaly at 23-week gestation.


A new method of analysis of light interaction with phase lattices limited in space is offered. The method is based on expansion of fields in spectra on the Kotelnikov-Shannon sampling function. this base system of the functions does not have information redundancy and permits one to define directly the power-generating characteristics of a diffracting light, instead of its complex amplitudes. The scattering field appears quantized. The signal is defined simply by the sum of powers of elementary beams in the received aperture. The absence of redundant information about a phase rather simplifies the solution. The possibilities of the method are illustrated by examples of Bragg's diffraction on coherent sound, transition in scattering with decreased degree of coherency, transition in Raman-Nath regime at decreased thickness of the volume of interaction.


One of the causes of middle lobe syndrome is primary ciliary dyskinesia. This diagnosis was established in an eight-year-old girl by functional studies of the cilia on bronchial and nasal biopsy specimens. The clinical approach to this disease is emphasized and the technical difficulties raised by the diagnosis are discussed.


Vehicular Networks are receiving a lot of attention due to the wide variety of services they can provide. Their applications range from safety and crash avoidance to Internet access and multimedia. A lot of work and research around the globe is being conducted to define the standards for vehicular Communications. These include frequency allocation, standards for physical and link layers, routing algorithms, as well as security issues and new applications. In this paper we review the standardization work and researches related to vehicular networks and discuss the challenges facing future vehicular networks. millions of people around the world die every year in car accidents and many more are injured. Implementations of safety information such as speed limits and road conditions are used in many parts of the world but still more work is required. Vehicular Ad Hoc Networks (VANET) should upon implementation, collect and distribute safety information to massively reduce the number of accidents by warning drivers about the danger before they actually face it. Such networks comprise of sensors and On Board Units (OBU) installed in the car as well as Road Side Units (RSU). The data collected from the sensors on the vehicles can be displayed to the driver, sent to the RSU or even broadcasted to other vehicles depending on its nature and importance. The RSU distributes this data, along with data from road sensors, weather centers, traffic control centers, etc to the vehicles.


Although more than a thousand related articles were reviewed in our literature survey, no references were ever found in them or in their bibliographies crossing from one level, say the neurophysiology of the cell, to another, such as group psychology. In one article an offhand suggestion was found that such generalization might be possible, but it was apparent that in present-day behavioral science cross-level similarities are rarely considered and general systems properties seldom taken into account. This, despite the fact that at all levels comparable performance curves have been discovered. Since such general systems characteristics are not sought, the same phenomenon, with different names, different dimensions and units, is being discovered over and over again at different levels. Known for many years in neurophysiology, it is only recently being recognized at the individual level. Yet it is probable that, if information input overload causes similar performance curves and mobilization of comparable d...


STI-571 (imatinib mesylate) is the prototype for signal transduction inhibitors. It is the model for rational drug design, in that it targets the genetic mutation of the disease. STI-571, a 2-phenylaminopyrimidine, is a highly selective inhibitor of the protein tyrosine kinase family, which includes BCR–ABL protein, the platelet-derived growth factor (PDGF) receptor and the c-kit receptor. Chronic myelogenous leukaemia (CML) is a stem cell disorder characterized by the Philadelphia chromosome and is dependent on the constitutively active tyrosine kinase protein BCR–ABL. In the CML model, STI-571 competitively binds to the ATP-binding site of the BCR–ABL and inhibits protein tyrosine phosphorylation. This review begins with a historical overview of CML therapy, then discusses STI-571 and its impact in the treatment of CML via clinical trials. The second part of this review addresses the issue of CML resistance to STI-571. A summary of the currently known mechanisms of resistance and the available options to overcome resistant disease is reviewed.


This paper presents a system for 3D reconstruction using a camera combined with an inertial sensor. The system mainly exploits the orientation obtained from the inertial sensor in order to accelerate and improve the matching process between wide baseline images. The orientation further contributes to incremental 3D reconstruction of a set of feature points from linear equation systems. The processing can be performed online while using consecutive groups of three images overlapping each other. Classic or incremental bundle adjustment is applied to improve the quality of the model. Test validation has been performed on object and camera centric sequences.


The indoor antenna range at Stellenbosch University was substantially modernised during a recent upgrade. Now, this antenna range contains five automated motion stages, plus one manual stage, that facilitate redundant planar and spherical near-field measurements using an integrated system. In this paper, this capability is used to investigate the effect of potential sources of reflection in the range.


This project deals with the analysis, modeling and control system for permanent magnet synchronous generator (PMSG) based wind turbine connected to the grid. An ac/dc/ac power converter is an important device used to extract power from variable speed permanent magnet wind generators and feed it into the grid. This paper describes how these converters incorporate maximum power point tracking based on its power feed to the grid at different wind speeds. Using the permanent magnet generator voltage, grid current, and grid voltage samples, the proposed system achieves an enhanced dynamic behavior. The thyristor controller also protects the inverter from high dc voltage input from the wind generator at high wind speed. Preliminary results are included using a laboratory 2-kW prototype converter. A 2 MW wind energy conversion system (WECS) is presented and has been simulated via the dynamic simulation . This WECS consists of a 2 MW permanent magnet synchronous generator connected to the transmission grid through a power conversion scheme.
 The topology of this converter system consists of a passive AC/DC rectifier as well as a PWM DC/AC IGBT inverter, used to interface the DC link with the grid. The inverter has an integrated current control system for power factor correction to improve output power stability.
In this paper, an isolated wind energy conversion system is implemented using a variable speed permanent magnet synchronous generator (PMSG) with PWM rectifier and a battery for storing the excess amount of wind energy. To change the duty cycle of the converter, a controller of DC-DC buck converter with MOSFET as a switching component is designed using P, PI and PID controller to provide the efficient choice for the selection of the controller. The proposed scheme is implemented in MATLAB using Simulink & the simulation results show that the output voltage of the converter can be controlled according to the value of duty cycle and the excess power is stored in battery to provide balance between the generator and the load


THE STEEL GIRDER DESIGN PROGRAM BLOCK AND THE GENERAL LOADING CAPABILITIES ARE DESCRIBED. THE STEEL GIRDER DESIGN PROGRAM BLOCK GIVES THE ENGINEER ANALYSIS AND DESIGN CAPABILITIES AS REPRESENTED BY THE COMPUTER PROGRAMS, AND ALSO COMMANDS THAT ENABLE HIM TO INTERACT WITH AND CONTROL THE DESIGN PROCESS ACCORDING TO INDIVIDUAL REQUIREMENTS. THIS PROGRAM BLOCK IS CAPABLE OF DESIGNING ROLLED SECTIONS WITH OR WITHOUT COVERPLATES, SIMPLE OR CONTINUOUS GIRDERS, AND COMPOSITE OR NON-COMPOSITE ACTION IN ACCORDANCE WITH ALLOWABLE BENDING STRESSES. THE GENERAL LOADING DESCRIPTION BLOCK PROVIDES CAPABILITIES OF ANALYZING AND DESIGNING CONTINUOUS GIRDERS OF A BRIDGE FOR AN UNUSUAL TYPE OF LIVE LOAD, SUCH AS A RAPID TRANSIT TRAIN OR MILITARY VEHICLE. THE ENGINEER DESCRIBES HIS LOADING USING A LANGUAGE DESIGNED FOR THAT PURPOSE. /BPR/


Power System Stabilizers are used to improve small-signal stability of power system. A conventional lead-lag based power system stabilizer does not give satisfactory performance under continuously variable conditions. In this paper Fuzzy Power System Stabilizer is proposed to improve small-signal stability of the Single Machine Infinite Bus system. The effect of excitation system, Automatic Voltage Regulators on small-signal stability is also studied. Fuzzy Power System Stabilizer is tested under various disturbance conditions. Simulation results reveal that Fuzzy Power System Stabilizer give better performance than conventional power system stabilizer.


With the rapid development of the technology of computer and internet, the diffusion and copy of digital products have become more easy. So, the copyright protection of digital products has already become a very important issue. In this paper, the software watermarking technique is presented in detail. An overview of software watermarking including the taxonomy, the current methods and their advantages and disadvantages are presented in this paper. Finally the state of arts and possible new directions of software watermarking are also stated.


A method is outlined for the preparation of a soluble form of glucono-dehydrogenase from P. fluorescens. The use of this enzyme enables a simple, specific and accurate determination of gluconic acid in complex biological media.


Recent years have seen an increasing interest of multiagent system research in employing the theory of argumentation for the development of communication protocols. While significant progress has been made in formalising argument-based communication, (possibly adaptive) agent-level argumentation strategies as a practical integration of rational agent reasoning and inter-agent argumentation dialogues have received fairly little attention. In this paper we propose the use of the InFFrA framework in argument-based negotiation. This framework allows for a strategic and adaptive communication to achieve private goals within the limits of bounded rationality in open argumentation communities. The feasibility of the approach is illustrated in an agent-based web linkage scenario, showing that its performance is comparable to that of simple proposal-based negotiation while accommodating much stricter constraints regarding "what can be said" like those used in argumentation.


The travel and hotel industry is one of the industries experiencing rapid growth. As the population grows, the need for travel and accommodation services gets higher. This is one of the factors contributing a rapid increase in such service industry. Competition in the economy and business world is getting tougher from year to year both within a country and abroad. Considering that Indonesia is a country comprised of many islands with a variety of natural beauty, it has the very potential for tourist resort attraction. This kind of thing leads to the growth of the Hotel and Travel industry to support tourism development. With such rapid service industry development, supported by promising business opportunities, investors for such sector are encouraged. The right way to reduce risk for investors interested is to develop a system for estimating the stock prices. Therefore, in this study, the stock price estimation method applied for travel companies adopted Advanced Kalman Filter, a comparison of H-Infinify and Unscented Kalman Filter (UKF) as a chart for investors to take into consideration in their investment decision making. The simulation results showed that the UKF method had higher accuracy than the H-Infinify method with an error by the UKF of 3.2% and that by the H-Infinify of 9.6%.


This literature review examines the available information on the macro-economic effects of an active labour market policy (ALMP). In recent years, several micro-economic evaluations have been conducted in this field. The situation in terms of macro-economic evaluations is clearly different. The number of available macro studies is rather limited, they tend to use very different methodologies, and the search results are often contradictory. This should not be a reason for shelving these macro-economic effects as unimportant. On the contrary even, these macro-economic effects (and a fortiori, the absence or very limited scope of these effects as suggested by contemporary empirical literature) are the ultimate test for assessing whether it makes sense to continue a given policy. In view of the social justification of the huge budgets that are going towards activating policy, it is safe to say that more money needs to be invested in such evaluations and in developing an appropriate methodology.


Understanding the mechanism responsible for electron emission from ferroelectrics is crucial for the design of ferroelectric cathodes. The mixed process suggested in the model of Zhang et al. [J. Appl. Phys. 83, 6055 (1998)] appears to contain some contradictions. The most problematic is the coexistence of two electron emission processes on the same surface in different electric fields.


Abstract : Hydrogen absorbed by steel parts during the cadmium plating process can cause cracking failures in service. This feasibility study was concerned with the effects of precoating steel with an electroactive coating on the amount of hydrogen absorbed during subsequent cadmium plating. Redox couples having rather negative standard redox potentials were successfully immobilized on steel surfaces. However, these coatings either had no effects or increased the amount of hydrogen absorbed during the cadmium plating step. Possible reasons for this behavior are given in this report along with other pertinent experimental findings. Alternate approaches to solving the hydrogen absorption problem are discussed. (Author)


1Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China; 2College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, People's Republic of China; 3Department of Pharmacy, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, People's Republic of China; 4Department of Food Science and Biotechnology, Cha University, Seongnam, 13488, South Korea; 5Department of Public Health, Our Lady of Fatima University, 838 Valenzuela, Philippines


This Thesis is written to obtain the Master of Science degree of Maritime Technology at Delft University of Technology. It describes a research regarding with the calibration(parameter identification), validation and linearization of a ship propulsion system model. In the meantime, the Thesis is also one sub-project under the research program "Potential of Hardware-In-the-Loop Simulation in the Towing Tank" held by Dr.Ir.A.Vrijdag. HIL (Hardware-In-the-Loop) Simulation is widely used in Engineering Technology Field, and has been proved to be a very effective, highly-efficient, economical and environmental friendly strategy in the test and development of engineering control systems. The model scale ship tests nowadays, on the other hand, need to be improved and HIL Simulation provides an innovative a creative way, therefore it is reasonable to start the program and explore more in this field.


SOURCE CITATION
Haykal T, Zayed Y, Deliwala S, et al. Direct oral anticoagulant versus low-molecular-weight heparin for treatment of venous thromboembolism in cancer patients: an updated meta-analysis of randomized controlled trials. Thromb Res. 2020;194:57-65. 32788122.


ThE short fiction of Fernán Caballero, penname adopted by Cecilia Böhl de Faber (1796–1877), is principally praised for its costumbrista depictions of the Spanish countryside and the local traditions native to it, in which Caballero "archiv[a] el recuerdo de lo que va a morir" (Montesinos 34). While these traditional landscapes largely portray Andalusia, "La flor de las ruinas" (1857) strikingly depicts the picturesque promenades and crumbling ruins of early nineteenth-century Lisbon.1 This relación commands critical attention not only for this departure from the paradigmatic Andalusian setting, but because the focal point of the Lisbon cityscape is the untouched ruins of the disastrous earthquake that leveled the city in 1755. To be sure, the description of the ruined city conforms to Caballero's approach to costumbrismo. It is a picture of nostalgia that condemns incipient modernity, a vision of deterioration frozen in time that goes unnoticed by the hurried passersby, whom Caballero describes as separated from the 1755 catastrophe "por lo que anonada y destruye más que la muerte, que es el olvido" (205). Critics cite a "curiosidad fotográfica" (herrero, Nuevo 292) as the genesis of the costumbrista depictions, and have pinpointed numer-


or O'Buda on the right bank of the Danube, of Celtic origin, was occupied by the Romans in a small way probably as early as the time of Claudius; afterwards, perhaps under Domitian, a legion was stationed there, though it is not certain that it was II Adiutrix, which we find there from the time of Trajan to the end of the fourth century when the place was abandoned. Dr. Kuzsinszky's little guide, translated into rather quaint English by Stephen de Zombory, briefly describes the excavations and contents of the Museum. The third publication seems, to one innocent of the Magyar tongue, to cover the same ground more fully and with illustrations both of the buildings and. of the objects in the Museum. The ' Annual' contains articles by Nandor (Herakles and Omphale, with reference to a fine ivory relief in the Museum), Foerk (the aqueduct of O'Buda and recent finds at the Viktoria brickworks), Kuzsinszky (grave-find at Aquincum, including a trinket with the well-known tag Xtyoviriv d 9(\ov<nv K.T.\.) and Kremmer (Pest-Buda in German engravings).


Developments in the field of automated mobility will greatly change our mobility and the possibilities to get from one place to another. This paper presents different scenarios for personal mobility in Austria, anticipating the possibilities and developments in the field of automated vehicles (AVs). The scenarios were developed using a systematically formalized scenario technique and expand the social and political discourse on automated mobility, which is currently characterized by a lack of experience and visibility as an established transport service. Using system dynamics modeling techniques, i.e., the Metropolitan Activity Relocation Simulator (MARS), impacts of the scenarios on the Austrian transportation system are estimated. The simulations show that, without suitable transport policy measures, automated mobility will lead to a significant increase in the volume of individual traffic and to modal shift effects with lower traffic volumes for public transport, walking and cycling. In addition, without a link between AVs and post-fossil propulsion systems, increases in pollutant emissions can also be expected. In contrast, the simulation results of an increased use of AVs in public transport show positive effects for the support of a more sustainable mobility. Hence, transport policy measures accompanying the introduction and development of automated vehicles will be needed in the future to reach a sustainable development.


Objective: To assess the fear of laboring women regarding the delivery on themselves and theirnewborns.Methodology : A descriptive study was conducted on (100) pregnant women who where admitted tolabor room in Al- Yarmock Teaching Hospital/Maternity Units, Fatima Al- Zahra and Ibn-Al BaladiMaternity and Pediatric Hospital. The questionnaire was consisted of pregnant womensocio-demographic data, reproductive data and fear items of labor. Data were collected by using aquestionnaire format, through interview technique and reviewing pregnant records, descriptive andinferential statistical procedure were used to analyze the data.Results: The main results of the study revealed a high mean of scores with moderate (RS) in women'sfear regarding labor on her self ( labor difficulties ,dying during labor, labor pain related to uterinecontractions, prolonged labor, fear of being left alone, fear of episiotomy, and exposure to infection )And on their newborn in (delivery of unhealthy or abnormal newborn ,newborn death during or afterdelivery, head dystocia, fetal asphyxia, and exposure to cold and infection ). The findings alsopresented significant differences between women's fear regarding labor on themselves and sociodemographic and reproductive variables in (age, education, residency, socioeconomic status, history ofabortion, pregnancy &delivery complications ), and on their newborn in (age, education, type of family.gravidity, parity, history of abortion, &pregnancy complications).Recommendation: Educational program can be designed to orient the pregnant women towardphysiological and psychological changes during pregnancy, labor & delivery process and Initiation ofprenatal education classes in primary health care centers.


With the outbreak of the Coronavirus, the world witnessed new events that had never been seen before. The effects of the Coronavirus will undoubtedly remain with hu - manity for many years. Social media continued to be very popular among users during the pandemic. This attention was not only from individuals but governments and organizations as well. This increasing importance of social media makes it very important to examine the role of social media during the pandemic. In the criticism of media influences, technopoly is one of the macro theories. This theory predicts the control of culture and thought by technology in today's world and provides us with the appropriate tools to study the role of media. In this article, we criticized the role of social media in the Corona pandemic using the analytical-critical method and based on technopolitical theory. First, the technopoly theory will be explained, then the role and effects of social media during the Corona pandemic will be examined by this theory. The study's find - ings suggest that Neil Postman in Technopoly Theory had predicted many of the harm - ful effects of the media, but we can also overcome these effects. According to Postman, it is possible to trade with technology and media. In various cases, human beings have succeeded in using technology to solve the problems of the Coronavirus.


On 23 February 1921, Captain Plant departed Shanghai for England with his wife of 27 years, Alice, and two unnamed children on his first home leave since arriving in China in 1898. Within days of the journey, Plant died of pneumonia at sea and Alice succumbed to heart failure at port in Hong Kong. News accounts recorded Plant's death as a 'calamity' for 'naval authorities of all nationalities, [and] more especially the British, together with all those interested in shipping....'


Claims of biased decision making occur in many disciplines, including lending, hiring, and policing. However, it is typically difficult to rigorously assess these claims. This is in large part because of well-known problems with the two most common statistical tests for discrimination: benchmarking and outcome tests. We develop a new statistical test of discrimination — the "threshold test", that mitigates some of the problems affecting existing tests. Our test uses a hierarchical latent Bayesian model to jointly estimate the decision thresholds applied by decision makers, and the risk distributions for different populations. We apply our test to a dataset of 4.5 million police stops in North Carolina, where we find that officers apply lower standards of evidence when searching minorities than when searching whites.


Conducting usability evaluations in applied military environments is notably different from traditional usability testing, as such environments pose restrictions on when, where, and how testing is conducted. In addition, specialized experience needed from military personnel pose challenges to recruitment and obtaining sufficient time with representative end users. This paper will discuss some challenges and lessons learned for consideration before, during, and after usability assessment data collection. Main recommendations include: recruiting experts qualified to provide feedback that aligns with the purpose of the evaluation; developing a flexible research protocol to allow for the maximum participation possible from any and all involved; and conducting domain research to supplement the researchers' own knowledge base to minimize reliance on SMEs. Finally, it is important to carefully document not only results, but knowledge and experience gained from specific efforts in order to assist future researchers in conducting work with similar systems.


Objective To lay the foundation of biological expression studies of growth hormone deficiency gene therapy with transplanting cell of recombinant human growth hormone gene in vivo. Methods After construction of a human growth hormone retrovirus expression vector pLXSNhGH, The recombinant vector was transfected into packaging cell lines PA317 via lipofection, G418 select resistant colony, the virus were collected from the virus containing supernatant of packaging cell lines, primary mouse embryo fibroblast cells were infected. The cells were transplanted at donor intraperitoneal sites and were detected in the donors circulation. Results Fluctuating levels of human growth hormone were detected for over 2 months due to interference by high titers of antibodies developed against the human growth hormone. Conclusions Primary fibroblasts tranfected by recombinant human growth hormone gene can produce novel gene products lasting for over 2 months, which lay the foundation of growth hormone deficiency gene therapy in vivo.


200-fs 6mJ pulses from a cw-diode-pumped Yb:CaF2 MOPA are spectrally broadened in an Ar- or Ne-filled hollow-core fiber and recompressed to 20 fs (Ar) and 40 fs (Ne) using a prism pair.


The design of confining steel in the United States codes is not related to the expected performance of the columns. Also, there are several parameters that significantly affect the behavior of confined concrete, but are not considered by the codes. These variables, including the distribution of longitudinal and lateral steel, tie spacing, and the level of axial load in the case of combined axial load and flexure, were investigated in this study. The study included an experimental program involving fifteen 12-in square and 9-ft long columns. The details of the study are described, the results are discussed, and conclusions drawn are presented.


more detail. Priced at £22.50, it has a slight edge on Birds at £25 and in these days of student poverty where cheap books are essential, it is competition that brings down the price. However, for the small difference in price, Birds contains more information. I would happily recommend this book for purchase by my students as an alternative to Birds and without necessarily preferring one to the other. Both serve the purpose. To expect them to read both is the sort of notion that, unfortunately, smacks of unrealistic idealism. RICHARD BRAGG*


We suggest the principally improved technique of the laser-induced doping by irradiation of the In/CdTe structures from the CdTe side with YAG:Nd laser pulses (λ = 1064 nm, τ = 8 ns). The computer simulation of laser heating and temperature calculations were used to choose the optimal regimes for achieving the effective In doping of thin and thicker CdTe layers near the CdTe-In interface under laser irradiation through the CdTe bulk. The formed M-p-n In/CdTe/Au diodes were tested by electrical and spectral measurements. The diode detectors showed sharp rectification with low leakage current and good energy resolution.


Uncharacterized protein C10orf107 (208 aa, ~24 kDa) is encoded by the human CABCOCO1 gene. This protein may play a role in blood pressure regulation.


The development of high power, high thrust ion engines requires the development of long life hollow cathodes capable of producing emission currents of hundreds of amperes. This paper describes results obtained through the extended testing of two 12.7 mm diameter hollow cathodes at high emission currents. The first cathode, operated on xenon for a total of 170 hours at an emission current of 100 A, sustained very little damage except for an increase in the cathode orifice diameter, from 0.953 to 1.71 mm. The second cathode was operated on xenon at 150 A emission current continuously for 24 hours, and for over 1000 hours at 100 A on argon with essentially no change in the cathode operating characteristics. Operation of this cathode was terminated due to severe erosion of several discharge chamber components located downstream of the cathode. The erosion of these components occurred despite operation at discharge voltages less than 24 volts, and poses a serious challenge to the sucessful implementation of multi-hundred ampere cathodes and high thrust ion engines.


We present a logic based approach to web services discovery and matchmaking in an e-commerce scenario. In particular, we describe our framework, based on Description Logics formalization and reasoning, and its deployment in a prototype, which overcomes simple subsumption matching of services descriptions and allows match ranking and services classification. We also present results of first experiments testing the performance of our prototype in a realistic e-commerce


A separation procedure was developed for analysis of polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in urban air, while simultaneously eliminating the interfering compounds. This was carried out by optimization of a column chromatograph with regard to the eluent type (n-hexane and n-pentane), volume of eluent, type of sorbent material (silica gel and florisil) and activation level of the sorbent material. The determination of the level of PCBs and PAHs was carried out using gas chromatography (GC) equipped with a mass selective detector (MSD), while determination of the OCPs was carried out by GC equipped with an electron capture detector (μ-ECD). The use of a silica gel column (10 g, 5% deactivated with H 2 O) with 70 mL of n-hexane gave satisfactory separation of PCBs from PAHs and OCPs. After collecting the PCBs with 70 mL of n-hexane, 3 ·20 mL of n-hexane:ethyl acetate, (1:1, v:v) was adequate for elution of the PAHs and OCPs from the column. The primary aim of this study was to develop a multimethod for analyses of PCBs, PAHs, and OCPs in urban air as well as reducing solvent and sorbent consumption and analysis time during the clean-up procedure compared to the US EPA standard methods (EPA methods TO-13A for PAHs and TO-4A for both PCBs and OCPs).


Nine series of liquid crystals containing an electron-donating group at one end of a conjugated system and an electron-withdrawing group at the other end have been synthesized. The electron-donating group is 4-n-alkylpiperazine and the electron-withdrawing group is the nitro group; and the conjugated system is diphenyldiazene with zero, one or two substituents on the phenyl ring not containing the nitro group. The substituents are-F,-Cl, and-CH3. Most of the compounds synthesized are nematogenic and exhibit rather broad liquid crystalline ranges. The effects of the lateral substituents on the optical absorption and phase transition temperatures are correlated with their nature and position of substitution. Dielectric anisotropy and birefringence measurements were made using mixtures containing 10 wt % of synthesized liquid crystals dissolved in commercial mixture E7.


We provide evidence that the quality of health care affects health outcomes, exploiting the substantial variability in the quality of the Italian public health service. The data are drawn from the 2001 Survey of Health, Aging and Wealth, providing detailed information on health status, and detailed demographic and economic variables for a sample of about 2000 individuals older than 50. The correlation between quality of health care and health outcomes is also confirmed in the panel section of the 1993-95 Bank of Italy Survey of Household Income and Wealth. The Survey contains an individual indicator of the quality of health care services, which allows us to measure the impact of quality on health status controlling explicitly for regional effects. We find that raising the quality of health care from the level of the poorest quality regions to the sample average increases the probability of excellent health outcomes by 1.1 percentage points.


Circular economy and mainstream economics don't contact on natural resources and environmental perspective.As early as classical economics,natural resources and the environment was regarded as factors of production with scarcity just like land and labor and resource value compensation is one part of mainstream economics.The development and promotion of circular economy are more reliance on research methodology and measurement tools of mainstream economics,so the consistency of the two is far greater than their differences.


To study the etiology and clinical feature of chronic pancreatitis. The etiology and clinical feature of 135 cases with chronic pancreatitis collected in our hospital from 1994 to 2004 were retrospectively analyzed. The main causes of chronic pancreatitis were biliary diseases (31. 85% ) , alcoholic (35. 56% ) , and other causes such as idiopathic, autoimmune diseases, trauma and heredity etc. The frequency of the different kind of clinical manifestations in alcoholic chronic pancreatitis was higher than that in biliary chronic panreatitis. TG, HDL - C TG/HDL - C in patients with alcoholic chronic pancreatitis were obviously different from those in patients with nonalcoholic chronic pancreatitis and controls group. The main etiology of chronic panreatitis is biliary diseases and alcoholic factor. But the alcoholic factor has the increasing inclination in recent years. The frequency of the different kind of clinical manifestations in alcoholic chronic pancreatitis was higher than that in biliary chronic panreatitis. TG/HDL - C ratio probably helps in differentiation in alcoholic and nonalcoholic chronic pancreatitis.


The character and conduct of the manager has formed a central focus of attempts to govern economic life throughout the present century. and current programmes of organizational change involve radical attempts to reconstitute the nature and conduct of management. This is attempted through the identification and implementation of management competencies. Discourses of organizational reform such as human resource management, total quality management and business process re-engineering all place a critical emphasis on anti-bureaucratic, organic and flexible forms of organization, which are also seen to require the development of particular capacities and predispositions among managers. Essential to their vision of 'managerial work' is a composite of 'entrepreneurial' attributes. Management competencies appear to offer a congenial method for the reconstitution of the manager along 'entrepreneurial' lines, not simply because they are inherently founded on managers'self-management and self-presentation of identified behaviours, but also because they represent individualized forms of business functions (and are often associated with the establishment of market relations within the organization). Copyright 1996 Basil Blackwell Ltd.


The invention discloses a distant health managing and medical system, which comprises the following parts: human physiological measuring device, customer end data transmission device, distant data managing platform and back end data transmission display device, wherein the user utilizes individual physiological measuring device to produce each kind of physiological information; the customer end data transmission device transmits the information to the distant data managing platform, which utilizes the back end data transmission display device to provide to the traditional Chinese doctor, western Chinese doctor, preventing medical unit to make analyze the user's physiological information; the invention reaches the life-lengthening goal of human body.


he first paper "A Fault-Tolerant Reservation-Based Strategy for Scheduling Aperiodic Tasks in Multiprocessor Systems" is by C. Yang and G. Deconick. They propose a fault-tolerant reservation-based strategy to schedule aperiodic tasks by utilizing the processor time left unused by periodic tasks. The least upper bound of reserved processor time is derived analytically so that all available processor time may be exploited for servicing aperiodic tasks, thus the processor utilization is improved. Any newly arrived aperiodic task is scheduled on the first-fit processor with a dynamic schedulability test. The primary/backup approach is used to schedule the primary and backup copy of each task on different processors to tolerate a processor failure. The second paper by R. Goncalves and P. Navaux is entitled "Improving SMT Performance Scheduling Processes". The paper evaluates a simultaneous multithreaded architecture, called SEMPRE, that is directed to execute independent processes on workstations and network servers. The simulations showed process scheduling by hardware can provide reasonable performance over process scheduling by operating system on equivalent simultaneous multithreaded architectures, with little addition of hardware. This advantage is achieved because the hardware makes better use of processes' time-slice. The third paper "The Iso-Level Scheduling Heuristic for Heterogeneous Processors" is by O. Beaumont, V. Boudet and Y. Robert. They present a new scheduling heuristic for heterogeneous processors, which improves the loadbalancing achieved at each decision step while keeping a low complexity. Experimental comparisons with five heuristics taken from the literature (BIL, GDL, CPOP, HEFT and PCT) and using six classical testbeds, show very favorable results. The fourth paper by I. Drositis, T. Andronikos, G. Manis, G. Papakonstantinou and N. Koziris is entitled "Geometric Scheduling of 2-D UET-UCT Uniform Dependence Loops". The paper presents the problem of scheduling uniform dependence loops using wavefront prediction. They study a new method for transforming UET-UCT problems to UET equivalent ones and present a simple and low complexity scheduling algorithm for the general execution model that also considers communication delays (UET-UCT model). T


It is considered good pedagogical practice for undergraduate social science students to reflexively use their real‐life experiences to illustrate concepts and theories, especially in relation to themes of social inequality and power. When teaching gender and sexuality, this can become problematic because of the emotional topics involved such as rape, domestic violence and pornography. Inevitably some female students will have experienced sexual assault or domestic violence, whilst male students may feel uncomfortable and somehow to 'blame' when discussing topics such as rape and pornography. This article draws upon my experience of teaching gender and sexuality, where female students and some male students have made painful and emotional disclosures. I highlight the ways in which the relationship between lecturer and student changes, how boundaries are challenged, and how the learning journey becomes an emotional journey where the desire to help students takes precedence over the pedagogical role. The work of Hochschild is used to argue that teaching gender involves 'emotional labour' that is self‐managed and invisible in institutional terms. Finally, I consider how lecturers might cope with emotional labour and maintain boundaries between the personal and the pedagogic within the new academic workplace.


The inability of women to counter violence in their relationships with men places women at risk of acquiring HIV infections. To explore the connection between violence and HIV risk the International Center for Research on Women and the Health and Development Policy Project conducted studies and reviewed data to formulate recommendations for fostering linkages between the HIV/AIDS community and the antiviolence movement. This work revealed the extent of gender-based violence (the act or threat of physical sexual or psychological harm including domestic violence mutilation murder rape sexual coercion and sexual abuse) and noted that 25-50% of women have reported physical abuse by a present or former partner. Sexual coercion in which a person is forced or pressured to engage in sexual behavior against their will is experienced by a large proportion of women worldwide. Many women are powerless to negotiate condom use or monogamy or to protect themselves from a partner who abuses alcohol. The antiviolence movement can benefit HIV/AIDS prevention methods if the HIV/AIDS community accepts the following recommendations: 1) involve antiviolence advocates in HIV/AIDS program planning and research; 2) develop referral systems for victims of abuse identified through health care programs; 3) insure that condom promotion messages do not reinforce "machismo" or aggressive male behavior; 4) develop and test intervention strategies to change social norms which sanction violence and sexual coercion; 5) investigate gender-based violence and sexual coercion; 6) educate community leaders service providers and policy-makers about the link between violence and risk of HIV and sexually transmitted diseases; 7) address social changes to redress gender power imbalances; 8) enact legal reform to protect women victims of sexual violence; and 9) develop and ensure accessibility of acceptable female-controlled methods of protection.


The story about the man with Down's syndrome who had a 'do not resuscitate' order put in his medical notes without consultation (news September 19) raises some important issues.


Aims: To decipher the nitrogen fixing potential of Bradyrhizobium sp.
Study Design: Random sampling method was followed for the representative soil sample collection and Completely Randomized Design was used for the in vitro experiments.
Methodology: Six random locations in the Cuddalore district of Tamil Nadu (India) were selected and groundnut rhizospheric soil samples were collected during Feb 2019. Traits of Bradyrhizobium sp. were isolated by serial dilution method. Followed by the purification of isolates and the purified isolates were subjected for biochemical characterization studies. After confirming, the traits were evaluated and graded for their nitrogen fixing ability by Microkjeldahl assay.
Results: The highest count of Bradyrhizobium cells, reaching, 5.87 log10 CFU g-1 of dry soil was recorded from the samples of rhizosphere soil, collected at Thiruvamur location (Cuddalore taluk). Whereas the lowest population was recorded in samples collected from Ramapuram location of Cuddalore district. In terms of nitrogen fixation efficiency per gram of mannitol, the strains BM-1 and BM-5 fell into the first classification, while the second category included BM-3 and BM-6, followed by BM-2 and BM-4 to the third category based on their performance.
Conclusion: This study, clearly deciphers the Nitrogen fixing potential of Bradyrhizobium traits of groundnut crop and the species holds the promise of using them as the efficient nitrogen fixers in legume crops in future.


Some properties of Raman scattering resulting from; the solitons excited in the organic protein molecules have theoretically been studied in terms of the partial diagonalization of the soliton Hamiltonian. The transition probability and the differential cross-section of the Raman scattering are also given. The red-shift associating With the Stokes component of the Raman scattering obtained is found to be basically consistent with the experimental data in the systems.


Short-time triaxial compression tests of dry anhydrite, dolomite rock, limestone, sandstone, shale, siltstone, slate, and halite single crystals under pressure-temperature conditions simulating depths down to 30,000 feet reveal the following. 1. Invariably an increase of pressure at constant temperature increases the yield stress, but an increase of temperature at constant pressure reduces it. 2. An increase of pressure at constant temperature always enhances the ultimate strength. However, heating at constant pressure may raise the ultimate strength by increasing the ductility of work-hardening rocks. More commonly heating lowers the ultimate strength by eliminating work-hardening, so that even though a rock is more ductile, it is weaker because its yield stress is reduced. 3. In any event for all materials tested except the halite, the ultimate strength at any simulated depth exceeds the crushing strength at atmospheric conditions. Below about 15,000 feet the strength of halite is less than that at the surface. 4. The effect of heating up to 300°C. on the strength and ductility of anhydrite, dolomite, sandstone, and slate is small. However, the strength of limestone, shale, and siltstone at room temperature exceeds that at 300°C. by about 50 per cent, and of halite by nearly 7 times. Work in progress will more realistically simulate the natural environment of deeply buried rocks by introducing an independently controlled fluid pore pressure. It will be possible to assess the effects of confining pressure, pore pressure, and temperature separately and to predict the short-time deformational behavior of most sedimentary rocks for a wide variety of conditions.


ABSTRACTIn this paper, hot-wire anemometry (HWA) is used to experimentally investigate interactions between a fully developed turbulent boundary layer and wake of an elliptic cylinder where axis ratio (AR) of the cylinder is 2. The elliptic cylinder was located inside and outside a turbulent boundary layer with a thickness (δ) of 0.38B. Furthermore, experiments were conducted at different Reynolds numbers (13,250 and 26,500) based upon the smallest cylinder diameter (B). Mean velocity, turbulence intensity and higher-order central moments of velocity signals (i.e. skewness and flatness) measurements were performed using HWA upon wake-boundary layer interactions on a flat plate. Results showed that profiles of stream-wise mean velocity and turbulence intensity were greatly dependent on gap ratio (G/B) and Reynolds number (Re) in near-wake region. It was also observed that, except for G/B = 0.1, the wake-boundary layer interactions were faster at Reynolds number of 26,500 rather than 13,250. The interaction...


This work is concerned with projective synchronization of chaotic systems with different dimensions by backstepping method. The nonlinear controllers are proposed based on Lyapunov stability theory. The technique has been successfully applied to the hyper-chaotic Lü system and a Genesio-Tesi system. Numerical simulations verify the effectiveness and feasibility of the method.


Overcrowding is common problem for emergency departments (ED) and related decision making process. This is due to low staff availability, limited budget, high costs and high patient volume. The stated issues decrease the quality care of medical centres and EDs. Therefore, EDs and medical centre must implement highly efficient systems that maximise the utilisation of their available resources to minimise the cost and minimise time in system to maximise patient satisfaction. In this paper, computer simulation and CCR output-oriented data envelopment analysis (DEA) model are used to evaluate the efficiency of various alternatives to improve and optimise the quality care of EDs. Moreover, computer simulation is used to generate the related outputs for DEA model. DEA model is then executed with proper inputs and outputs to provide optimisation model from a list of potential alternatives. This is the first study that introduces an integrated simulation-DEA as an optimisation approach for handling patient satisfaction in the EDs.


To the editor: Factors with stimulating effect on haematopoiesis have been used in various clinical circumstances with promising results. Following intensive chemotherapy and after bone marrow transplantation, treatment with recombinant human granulocytemacrophage colony-stimulating factor (rhGM-CSF) results in accelerated marrow regeneration and a shorter neutropenic period compared to historical control patients. However, recent case reports describe aggravation/reactivation of autoimmune diseases such as idiopathic thrombocytopenic purpura (I) , haemolysis (2) and rheumatoid arthritis (3) and development of thyroid dysfunction in patients with pre-existing thyroid antibodies but previously normal thyroid function (4). We describe a patient with rapid deterioration of autoimmune hypothyroidism during infusion of rhGM-CSF. A 69-year-old male with acute myeloid leukaemia, FAB type M1 was randomised in a phase 111 open study of standard induction therapy with aclarubicin (75 mg/m2 intravenously on day 1-2) and cytosine arabinoside (100 mg/m2 every 24 hours as a continuous infusion on d 1-5) supported by E. coli-derived GM-CSF (Schering-Plough/Sandoz) given at a dose of 10 pg/d infused via a central venous catheter over a period of 3 h on d 0-21. There was no history of previous or actual thyroid disease, and physical examination before the trial showed no goitre or signs of hypothyroidism. As shown in Table 1 there was laboratory evidence of early thyroid failure (subclinical hypothyroidism) before randomisation, and a positive titre of antibodies to thyroid peroxidase (normal < 95 Ujml) (5 ) . During treatment with rhGM-CSF for 22d the patient developed symptoms of hypothyroidism (cold intolerance and lethargy) without inflammatory signs or enlargement of the thyroid gland. The dysfunction of the gland was documented by a rapid and marked decrease in serum T4 and T3 concentrations and a compensatory, but delayed hypersecretion of thyrotropin (Table 1). Moreover, a transient rise in antibodies to Table 1. Thyroid function and antibodies to thyroid peroxidase in a 69-year-old patient with autoimmune hypothyroidism before and after 22 days rhGM-CSF-administration


The physician's duty of "primum non nocere," or avoiding harm to the patient, has often been given moral priority over other duties in discussions of medical ethics. In this article in a British Medical Journal series written for nonphilosophers on the philosophical foundations of medical ethics, Gillon takes issue with the prominence given the obligation of nonmaleficence over that of beneficence. He argues that risking harm is often necessary to obtain therapeutic benefit, and that always giving nonmaleficence priority over beneficence in clinical decision making results in "therapeutic nihilism." These two important principles should counterbalance one another in medical care, with due respect for patient autonomy.


This article discusses the religiosity of the wives, the adjustment of wives of suspected terrorists against psychological and social burden, and the patterns of marital relations of terrorist suspects in Pekalongan-Central Java. This phenomenological study revealed that the religiosity of terrorist-suspects' wives are more dominant is exclusive patterned- if it is compared to moderate or inclusive ones. The wives of terrorist suspects consider that the real terrorists are not their husband, but the U.S. and its allies. In terms of adjustment, the wives are just accept the fate and tend to be indifferent to the activities of their husbands. The wives also nullifying the public's negative perception and judgment, but some are closed to the social interaction. While the pattern of relationships that were frequently built tent to be more owner property and head-complement in characteristics. Wives are positioned as husband's complement for all activities in the fields of social, religious and political.


Weight loss measurements and potentiostatic polarization studies show that tetrazospiro (5,5) undecane-3-thione (TUT) acts as an effective inhibitor for the corrosion of mild steel in I N Hel and I N H~S04' This is also shown by hydrogen permeation studies by decreasing hydrogen permeation current through mild steel surface. Electrocapillary studies show that it is adsorbed on both the sides of the e!ectrocapillary curves. It's adsorption on mild steel from 1 N HCl and 1 N H2S04 is found to obey Temkin's adsorption isotherm. In continuation of our work I, on the development of nitrogen and sulphur-containing inhibitors, we report here the influence of 1,2,4,5-tetrazospiro(5,5)undecane-3-thione (TUT) on corrosion of mild steel In I N HCI and I N H2S04, The choice of this inhibitor i~ based on the fact that it can be synthesized conveniently from relatively cheap raw materials such as carbon disulphide, hydrazinehydrate and cyclohexanone and the presence of non-bonding electron pairs on nitrogen and readily polarizable sulphur atom is likely to induce greater adsorption of the compound on the surface leading to higher efficiency. Experimental Procedure Cold rolled mild-steel strips of size 5 x 2 x 0.025 cm (C = 0.14%, Mn = 35%, Si = 0.17%, S = 0.025%, P = 03 %, rest iron) were used for weight loss measurement ...: iiydrogen permeation studies. For potentiostatic polarisation studies, mild steel rod of same composition embedded in araldite with an exposed area of I em- was used. The electrodes were polished with emery papers of 1/0,2/0, 3/0 and 4/0 grade and degreased with trichloro-ethylene. For capillary electrometer studies, double distilled mercury was used for the working electrode. AR grade HC[ and H2S04 were used for preparing solutions. Double distilled water was used to prepare solutions of I N HCI and. I N H2S04 for all experiments except electrocapillary studies, where triple distilled water was used. The inhibitor I,2,4,5-tetrazospi ro( 5,Sjundecane- 3-thione (TUT) was synthesized according to the procedure reported elsewhere- and the structure of the inhibitor is as follow:


Police trap is one of the effectual means of collecting the evidence and tracking down the crime,while it confronts the dilemma of punishing the crime or protecting human rights.In order to limit the negative effects of police trap to the maximum extent,it is necessary to regulate the proof qualifications of the evidence obtained by it.By analyzing the admissibility rule of the evidence obtained by police trap,it is essential to discuss the legal elements of the evidence obtained by police trap,so as to establish the legal standards of admissibility of the evidence obtained by police trap.


Objective To explicate the effects of exogenous calcitonin gene-related peptide(CGRP)on rat osteoblasts in vitro,and to investigate the mechanism by which CGRP promotes bone formation.Methods The osteoblasts were isolated from newborn rat calvaria by sequential enzyme digestion,and the secondary cells were treated with different concentrations of CGRP respectively.After 24 hours of incubation,the effects of CGRP on proliferation and differentiation of osteoblasts were observed with MTT assay, 3 H-TdR incorporation and the determination of intracellular ALPase activity.Results CGRP could stimulate the proliferation of osteoblasts in dose-dependent manner,but was unable to affect the intracellular ALPase activity of osteoblasts.Conclusion CGRP can act directly on osteoblasts and increase bone formation by stimulating the proliferation of osteoblasts,but it does not promote the differentiation of osteoblasts.


This paper utilizes system principle to study on education system, clarifies its value purpose, entirety optimization, reasonable combination and interaction of its internal and external surroundings, and expect to play a positive role in higher education management.


In the fictions by Wang Xiaobo, the novelty and original of the narrative art show some characteristics of meta fiction. The most remarkable external features of meta fiction are that narrators self betray the imprint of depiction and fiction, even discuss all kinds of descriptive skills publicly in the texts. Wang Xiaobo first describes a plot or a feeling relatively perfectly, and then supplements them in some aspects. The author deliberalely exposes the narrators' identity, conducts the narrators' voices, reveals the action and the course of the depiction. To achieve the final goal, the author breaks plots and relationships and so on into pieces willingly or unwillingly, which is to avoid falling into traps of the depiction laid by himseif without law to follow, then put them together in his fictions, which constitutes the principal characteristics of the meta fiction of the stories written by Wang Xiaobo.


Real-time deformation and haptic rendering of virtual fabric can widely be applied in many fields. The popular virtual fabric deformation algorithmswereimplemented by the simplified Spring-Mass model, which ignored the fabric's anisotropy properties, and had the super-elastic phenomenon. And the popular haptic rendering algorithms could not simulate multi-points fabric haptic interactions. A dual-HIPs haptic interactive system was developed, which allowed users to feel virtual fabric with two contact points. This system not only considers the tension, compression, shear stress, bending of fabric, but also embodies the fabric's anisotropy properties. With two haptic devices, this system realizes double HIPs interactions with virtual fabric to simulate the intuitive behaviors of users.


Abstract : The study reported in this volume focused on the beachfront area (south of Lakeshore Drive) between West Beach Parkway and Bayou Castine, an area of approximately 44.5 acres. Seven backhoe trenches were excavated. Only a few artifacts were recovered, and most of these were non-diagnostic. Two of the trenches were placed at the suspected location of a portion of the 1895 wooden seawall. These trenches indicated that the seawall is in an advanced state of deterioration. The results of this study indicate that proposed construction will not impact significant archeological resources. Mandeville, St. Tammany Parish, Lake Pontchartrain, Seawall.


Description Faced with a family crisis, a marine scientist finds parallels with Earth's imperiled coral reefs Faced with a family crisis, a marine scientist finds parallels with Earth's imperiled coral reefs


The mechanism for near‐threshold photon‐stimulated desorption (PSD) and electron‐stimulated desorption (ESD) is examined theoretically using finite cluster, quantum chemical techniques to model the interaction of a hydrogen atom with a metal surface. Configuration interaction calculations on clusters modeling both the 〈100〉 and 〈111〉 faces of an fcc crystal yield a consistent picture of the process. A band of strongly repulsive states which asymptotically dissociate to ions is found to lie ∠25 eV above the ground state. This excitation energy is consistent with the threshold observed in ESD and PSD experiments on the 〈100〉 surfaces of Ni and Pd. The states of this band all involve double excitations from the metal–hydrogen bonding orbitals.


2. Beghe C, Wilson A, Ershler WB. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am J Med 2004; 116: S3–10. 3. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263–8. 4. Zakai NA, Katz R, Hirsch C et al. The Cardiovascular Health Study. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort. Arch Intern Med 2005; 165: 2214–20. 5. Joosten E, Pelemans W, Hiele M, Noyen J, Verhaeghe R, Boogaerts MA. Prevalence and causes of anaemia in a geriatric hospitalized population. Gerontology 1992; 38: 111–7. 6. WHO: World Health Organization. Nutritional Anemias: Report of a WHO Scientific Group. WHO Technical Reports Series 405. Geneva, Switzerland: World Health Organization, 1968. 7. Yip R, Dallman PR. The roles of inflammation and iron deficiency as causes of anemia. Am J Clin Nutr 1988; 48: 1295–300. 8. Penninx BWJH, Pahor M, Woodman RC, Guralnik JM. Anemia in old age is associated with increased mortality and hospitalization. J Gerontol 2006; 61A: 474–9. 9. Craig R, Mindell J eds. The Health Survey for England 2005: The Health of Older Adults. London: The Information Centre, 2007. 10. Bajekal M. Health Survey for England 2000. Care homes and their residents. London: The Stationery Office, 2002. 11. Guyatt GH, Patterson C, Ali M et al. Diagnosis of iron deficiency anaemia in the elderly. Am J Med 1990; 88: 205–9. 12. Hollyoak TL, Stott DJ, McKay PJ, Hendry A, MacDonald JB, Lucie NB. Use of plasma ferritin concentration to diagnose iron deficiency in elderly patients. J Clin Pathol 1993; 46: 857–60. 13. Joosten E, Van Loon R, Billen J, Blanckaert N, Fabri R, Pelemans W. Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anaemia. Am J Hematol 2002; 69: 1–6. 14. Casale G, Bonora C, Migliavacca A, Zurita IE, de Nicola P. Serum ferritin and ageing. Age Ageing 1981; 10: 119–22. 15. Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 1990; 75: 1870–6. 16. Alford CE, King TE, Campell PA. Role of transferrin, transferring receptors and iron in macrophage listericidal activity. J Exp Med 1991; 174: 459–46. 17. Ausk KJ, Ioannou GN. Is obesity associated with anemia of chronic disease? A population-based study. Obesity 2008; 16: 2356–61. 18. Ioannou GN, Dominitz JA, Weiss NS, Heagerty PJ, Kowdley KV. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology 2004; 126: 1293–301. 19. Chua E, Clague JE, Sharma AK, Horan MA, Lombard M. Serum transferrin receptor assay in iron deficiency anaemia and anaemia of chronic disease in the elderly. Q J Med 1999; 92: 587–94. 20. Punnonen K, Irjala K, Rajamaki A. Serum transferrin and its ratio to serum ferritin in the diagnosis iron deficiency. Blood 1997; 89: 1052–7.


A new parallel thinning algorithm for binary imageswas proposed and experimental results were shown in this paper.Being different from the previous template matching algorithm using the predefined small windows,the new algorithm gets the medial axis by analyzing the pixel-connection to thin down the shape of the object.It holds good for the thinning to the images of grain boundary microstructures.


Development in the ability to categorise phonemic contrasts was examined in 85 children aged 6 to 12 and thirteen adult controls using synthetic stimulus continua presented in identification tests. The range of contrasts included a stop voicing contrast (/g/-/k/ ), a stop place contrast (/d/-/g/ ), a fricative voicing contrast (/s/-/z /), a fricative place contrast (/s/-/S /), and a fricative-affricate manner contrast (/S/-/tS/). This study aimed to test: (1) whether there would be age effects in the sharpness of categorisation; (2) whether the sharpness of categorisation would differ across phonemic contrasts acquired at different stages of development and (3) whether children would give greater perceptual weighting than adults to cues marked by rapid spectral change. Shallower identification function gradients were obtained for the 6;0-7;6 year old group than for the 9 to 12 year old groups, and all groups of children showed decreased sharpness of categorisation relative to adults. As predicted, the stop place and voicing contrasts were categorised more sharply than the fricative place and voicing contrasts. There was no conclusive support for the view that children aged 6 or more still placed greater reliance on dynamic cues than older children or adults.


Subintimal arterial revascularization has a high technical success rate, but requires the ability to navigate between different planes/lumens of the arterial wall. While most failures are attributable to the inability to re-enter the true lumen distal to the occlusion, there are times where entering the subintimal lumen can be challenging as well. This chapter describes alternative strategies for both entering and exiting the subintimal plane during lower extremity revascularization.


During the XVIII century many foreign travels were undertaken from the Grand Duchy of Lithuania and there are over a dozen preserved diaries describing them. Some of these journeys led to Western Europe (for example those described by Krzysztod Zawisza and Tadeusz Bukaty) or to St. Petersburg, which was a popular destination among White Ruthenian nobles by the end of XVIII century. Other, like the one written by Ludwik Sienicki, are a testimony of a Siberian exile. Among the preserved relations are also three large diaries written by travelling clergyman (Juwenalis Charkiewicz and Ksawery Bohusz wandering throughout Europe and Antonii Burnicki to the Holy Land) as well as two descriptions made by women (Teofi la z Radziwillow Morawska and Salomea z Rusickich Pilsztynowa).


Taking stock of extant hospitality and tourism research using social network analysis approaches, this study highlights why using either quantitative or qualitative approaches to examine social networks can be misleading and generate potentially biased findings. Indeed, purely qualitative and purely quantitative studies display limitations. The purpose of this study is to provide methodological insights by suggesting that mixed methods can be suitably used, depending on the specific research questions.,The study consists of an analysis and critical discussion of the methods used in a number of papers leveraging social network approaches to study social networks in tourism and hospitality. The authors describe the benefits and limitations of each method studies considered are examined based on a number of aspects.,More than half of the studies classified as network studies adopt quantitative designs and quantitative methods including statistical analyses and observational data. Mixed methods study is a minority and they are almost never labeled as mixed methods. A relevant portion of qualitative studies increasingly embeds a number of rudimentary statistical analyses. With an example, the authors also discuss that purely quantitative or purely qualitative methods can lead to discrepant results, and thus, the authors encourage scholars to embrace mixed method research designs such as explanatory or exploratory sequential designs. Advanced researchers might attempt in the future to embrace transformative, embedded or multiphase mixed methods.,This study is based on academic papers and research published before 2019. A rich research agenda is designed.,This study contributes to explore the way social networks have been dealt with in tourism and hospitality research so far, by advancing a proposal to adopt mixed methods in the form of explanatory or exploratory sequential designs. To the best of the knowledge, it is the first study addressing methodological pitfalls in extant network-based research within the tourism and hospitality domain.


sk (W A IS -I II ) As expected, prior to any arousal manipulation (i.e., baseline) students with MHI performed more poorly on tasks of working memory (WAIS-III, 1997; DKEFS, 2002) and attention (DKEFS, 2002). , , implicated in the modulation of emotional and autonomic responses1. This region is particularly vulnerable in head trauma2 and, therefore, emotional responses may be at risk in this population. Consistent with this, research (see Tranel & Damasio, 19943) has shown that persons with moderate to severe traumatic brain injury (TBI) to the vPFC present with underarousal as evidenced by reduced electrodermal activation (EDA) responses and flattened affect. Furthermore, it has been suggested that individuals with moderate to severe neurological compromise are particularly vulnerable to the adverse effects of stress 4,5 . Until recently, little research has been conducted to examine the persistence of i l d i i l f ll i ild h d i j (MHI) i j i hi h University students (N = 91); 56% self-reported MHI history Measures and procedure Neuropsychological measures (memory17, 18; attention19; planning19; abstract reasoning18,19, 20; and standard intelligence18); indices of arousal/anxiety21; manipulated arousal (via psychosocial stressor22 or relaxation) Post-concussive symptoms (Post-concussive Symptom Checklist [PCSC])16 Indices of Anxiety physiological recordings of electrodermal activity [EDA] and heart rate23; STAI21; selfreported arousal levels; Everyday life stress 24 15 20 25 30 35


Ion thermal diffusion theory was applied to analyze the influence on numerical aperture and focal length of planar square aperture microlens array (PMLA). Moreover, numerical aperture and focal length with different ion-exchanging time but the same size of mask aperture were measured experimentally. Then, we measured the longitudinal and transverse spherical aberration by the method of parallel light incidence and emergent light pupil and improved the aberration of square-aperture PMLA by annealing treatment. Experiment results show that the spherical aberration is decreased obviously after annealing process. Meanwhile, imaging resolution is also improved more greatly. PMLA optical system with continuously adjustable focal length was proposed, which was made up of two pieces of square aperture PMLA and an aspherical lens and focal length can be adjusted continuously just by precisely adjusting the distance between the two pieces of square aperture PMLA.


This paper discusses the development of a car following model using reactive agent-based techniques based on a neural network approach for mapping perceptions to actions. The model's formulation is similar to the desired spacing models which do not consider reaction time or attempt to explain the behavioural aspects of car following. The models were developed using field car following data, comprising relative speed and headway between vehicles. A number of error tests were used to compare the performance of the agent-based model against established car following models using the field data. The results showed that simple back-propagation neural network models outperformed the Gipps and Psychophysical family of car following models. Qualitative drift behaviour; speed and headway profiles analyses also confirmed the findings. (a) For the covering entry of this conference, please see ITRD abstract no. E211903.


This article reveals the life of the Holy Trinity Bernardine nuns in Kaunas (Kowno) in the years 1842 to 1864, the worsening situation at the convent due to the Russian occupying government's policy, the actual closure of the convent, and the fate of the nuns after the closure of their home. The study aims to show how daily life at the convent affected the Russian administration's decisions regarding its material provision and particular nuns living there, how they were affected by the closure of St George's Bernardine Friary in Kaunas which used to be the main supporter of the Bernardine nuns, and relations between the Bernardine nuns and the bishop. The author analyses difficulties in community life and problems adhering to the constitution, and reveals the general mood of the nuns. The research is based on correspondence between the Bernardine nuns, the bishop and the convent visitator, memoirs, and material from visitations. This case study of the Kaunas Bernardine nuns helps us gain a better understanding of the situation of the Catholic Church in the Russian Empire.


XOR cipher is a message randomization algorithm by performing XOR logical operations for plaintext and key so that it becomes a ciphertext. The problem lies in the predictable use of XOR. Therefore, it uses key security using the Three Pass Protocol. This protocol secures communication for each party. The key used for Three Pass Protocol communication is Base64. The Three Pass Protocol scheme for XOR Cipher key security using Base64 has a weakness because it is due to the Base64 encoding process which by default is easy for others to know. So that this research can be developed again to replace Base64 into a better algorithm in terms of security.


Traditional culture which manifests the values, view of life, and world outlook established by the Chinese nation in long-term production and life has also become the cultural gene of Chinese nation. Folk art as one of the main carriers of traditional culture created by the masses in daily production and labor carries the people's expectations for a better future life and records folk custom activities. This paper first analyzes the abundance and diversity of folk art resources. Second, it analyzes the importance of carrying out folk art teaching in normal universities, conducts in-depth discussion on folk art teaching model in normal universities in the context of promoting traditional culture: a) Folk art teaching should be integrated with other courses; b) It is necessary to carry out social practice of intangible cultural heritage of folk art; c) It is necessary to construct folk art education system.


This study explores factors affecting changes in tax revenue diversification in Florida counties using socioeconomic, taxpayer, and institutional characteristics. The data cover 30 years and are analyzed using panel data analysis. The findings show that taxable consumption value, the number of interstate highways, the charter, and the form of government are associated with a greater degree of revenue diversification. Taxable property value, the presence of a metropolitan statistical area, the proportion of homeownership, the proportion of Democrat voters, income, and property tax millage rate are negatively associated with revenue diversification.


The synthesis of a series of calix[4]arene ligands bearing lower rim 1,3-acid-amide functionality for the two-phase solvent extraction of lanthanide and uranyl ions from aqueous wastes is described. X-Ray crystal structure studies demonstrate binding of lanthanide ions at the calixarene lower rim through phenolate, carboxylate and carboxamide oxygen atoms. The crystal structures of a centrosymmetric, dimeric lanthanum(III) and non-centrosymmetric dimeric sodium(I) complexes of a 1,3-acid-dihexylamidecalix[4]arene ligand are detailed. Electrospray mass spectrometry confirms retention of this 2 ∶ 2 dimeric structure for large lanthanide ions and that the smaller lanthanide ions e.g. Lu3+ form monomeric 1 ∶ 1 calixarene ∶ lanthanide complexes in solution. Extraction studies demonstrate a pH dependent uptake of lanthanide and uranyl cations by 1,3-acid-amide ligands with the nature of the carboxamide substituent largely
irrelevant to extraction efficiency. Upper rim modified 1,3-dinitro and de-tert-butylcalix[4]arene ligands were prepared and NMR and ES-MS studies confirm uranyl coordination by these novel acid-amide ligands. The 1,3-dinitro and de-tert-butyl ligands exhibit superior and more efficient extraction of uranyl cations at lower pH values.


The transmembrane protein gp130 acts as the signal transducing receptor subunit for interleukin‐6 type cytokines, including viral interleukin‐6, which is encoded by the Kaposi's sarcoma‐associated herpes virus. Viral interleukin‐6 has been shown to mimic human IL‐6 functions, including activation of the JAK1 and STAT1/3 signaling pathways. Based on the crystal structure of three extracellular domains of gp130 in complex with viral interleukin‐6, we have designed and synthesized a range of assembled peptides that mimic the sequentially discontinuous binding site of gp130 for viral interleukin‐6. These peptides, which present the three binding site fragments of gp130 in a nonlinear, discontinuous fashion, were shown to inhibit the interaction of gp130 with viral interleukin‐6, as well as the stimulation of viral interleukin‐6‐induced cell proliferation. These results validate the concept of synthetic mimicry of discontinuous protein‐binding sites through assembled peptides, and the use of such molecules as modulators of protein–ligand interactions.


This research is a descriptive qualitative study, in which descriptive qualitative research is used to depict or describe a situation is on the level of Quality of Hospital Inpatient Services In Undata. Judging from the number of visits patients, especially inpatients has decreased the number of visits that by 2015 as many as 11 192 visits by an average of 69 people a day visit while in 2014 as many as 14 871 visits with an average of 182 people per day. This study was conducted to determine how the Quality of Inpatient Services at Regional General Hospital Undata. The purpose of this study was to determine the quality of Inpatient Services at Regional General Hospital Undata seen from the aspect of tangible, reliability, responsiveness, assurance and empathy. In conclusion, the study proves that the quality of Inpatient Services at Regional General Hospital Undata turns considered less good, because in general there are still many complaints from patients and the public. The results of this study are expected to be useful in improving the quality of care in hospitals Undata, to suit the patient's expectations and the vision, mission Mission Hospital.


Introduction: Compared to the 2014 scheme, the 2017 GOLD COPD strategy uses only symptoms and exacerbation history to group patients, and no longer gives reference to the severity of airflow limitation. Aims: This post hoc analysis of TONADO and OTEMTO data aims to determine the impact of updated assessment criteria on patient classification and characteristics within these groups. Methods: TONADO (NCT01431274/NCT01431287; N=5162) and OTEMTO (NCT01964352/NCT02006732; N=1621) Phase III trials investigated efficacy and safety of tiotropium+olodatorol fixed-dose combination in COPD patients. In this analysis, patients were classed as GOLD A–D by the 2017 or 2014 criteria. In TONADO the mMRC Dyspnoea Scale and COPD Assessment Test were not used, so distinguishing between A/B and C/D was not possible. Results: In TONADO, assessment using 2017 GOLD criteria led to 35.3% more patients classified as A/B. In OTEMTO, assignment of patients to groups A and B increased; 191 (11.8%) patients moved from C to A and 327 (20.2%) moved from D to B (Figure). No changes in patient demographics were observed in the new groups. The 2017 criteria result in a spread of GOLD stages II–IV (lung function) across groups A–B. Conclusion: When we applied 2017 GOLD assessment criteria, several patients in TONADO and OTEMTO trials shifted into the lower A and B risk groups. This shift may have implications for treatment decisions.


A multi-agent system based energy-coordination by contract net protocol (MAS-ECCNP) is designed for to efficiently connect production units of energy renewable based wind-photovoltaic energy storage system (PUER-WPESs) to Grid. The negotiation protocol is a two-level bidding mechanism based on the contract net protocol. In the energy-coordination process, the proposed system allows the agent to cooperate and coordinate their actions taking into account their self-constraints and objective control to solve the optimal distribution plan overall energy and by the using the improved particle swarm algorithm to achieve the maximum economic benefit on the basic of stable operation. The paper presents the overall system design, the models of agents of different equipment, and overall energy optimizing coordination algorithm. An example is given to discuss the behavioral characteristics of negotiation and communication process based agent to verify that the system designed in this paper can achieve effective coordination of energy. The method adopted by this system can improve the efficiency of the overall operation and the economic benefits of REPU-WPESs.