Representing one of eighteenth-century Williamsburg's few known families of port resident-landowners and port workers, the Moody Family of Capitol Landing has not received as much interpretation in Williamsburg's scholarship or public history venues as the family's social histories and civic contributions deserve. As members of a small but essential segment of the city's port residential workforce located to the northeast of town on Queen's Creek, the Moodys of Capitol Landing are unique for being perhaps the best-known, best-documented, and longest-standing group of landowning port residents who both lived and worked in one of Williamsburg's ports from at least 1715 to approximately 1775. This three-generational family group, represented chiefly by Giles Moody, his son Matthew Moody, Sr., and Matthew, Sr.'s sons, Philip and Matthew Moody, Jr., were Capitol Landing's sole ferrykeepers and most enduring tavernkeepers roles which helped to establish, settle, and maintain the port and family itself. The Moodys also held minorto mid-level officeholding positions in York County government, were tradesmen and planters, and actively participated in a variety of community affairs in and around Capitol Landing, Williamsburg, and the surrounding counties during their sixty-plus years at the port. Residing on the geographical periphery of Williamsburg's urban core, amidst a port society likely inhabited by many highly transient, lower to lower-middling class, marginalized, and often unidentifiable port residents, workers, and visitors, the Moodys are notable amongst Capitol Landing's port residents for being extensively documented in the York County Records and a variety of other sources. The Moodys' records reveal evidence supporting a theory about which prior scholarship could only speculate; namely, that some of Williamsburg's port inhabitants did indeed sustain long-term residency at the ports, and in the process, were also able to become active participants and contributors in a variety of port, city, and county affairs and community networks. Indeed, though the family lived along the city's periphery in a highly transient zone, they were not peripheral or marginalized members of its society or culture, and they likely had the effect of providing a helpful measure of on-site social, infrastructural, and community stability in and around Capitol Landing throughout their lifetimes. This thesis seeks to fill a gap in Williamsburg's social history and public history scholarship by exploring the Moodys' long-term residency and participation in the port's and city's urban settlement and expansion, public transportation infrastructure, commercial export inspection, law enforcement, and other community affairs over the course of the city's 81-year reign. This study concludes with brief suggestions for ways in which this research may be practically applied and interpreted to present-day Williamsburg's public audiences at the Colonial Williamsburg Foundation and at the city's former eighteenth-century port sites of Capitol Landing and College Landing.


The development of the aeronautics industry has boosted numerical models over the last few years, both for fluid dynamics and for structural analysis. With this knowledge, the present research aims to study and perform numerical computational analysis for aerodynamic fluids to verify if it corresponds to the theoretical model described in the literature. In addition, this work addresses the numerical analysis using computational fluid dynamics (CFD) solved by the Reynolds averages equation for 2D airfoils. Two models of turbulence are used to compare numerical and experimental results, such as the Spalart Allmaras model and model. The work also addresses the process of creating the computational domain, as well as the process of creating the mesh, and boundary conditions. A more careful analysis of the phenomenon is made in the boundary layer region where the quality of the results and the physics involved are explained. At the end, the numerical and experimental results are compared, so that the numerical convergence for the support and drag is verified. The results were satisfactory to estimate the coefficient of support of the profile, so that the values approximated a lot of the experimental one with an error in the order of 10%, however, for model estimates the model did not converge to the expected values, presenting percentage errors in the order of tens. This is due to wall modeling conditions because the drag value is intrinsically connected to the shear stress value on the wall of the aerofoil.


Coronal fracture of anterior teeth is a common problem of children as a result of dental trauma particularly during sports. This fracture has its drawbacks on the smile appearance that may affect the psychic state of the child. Restoration of such fracture is very important to restore the esthetic of the smile. May techniques are available; the most conservative one is reattachment of the fractured piece. This article describes the reattachment of fractured fragment of left central incisor of a child. The fractured tooth fragment was successfully reattached using a very simple technique. Circumferential beveling and using of micro hybrid composite was sufficient to get a good esthetic and durable result. At the end of the treatment, the patient was very happy and satisfied.


The present invention provides a simple, non-preference issues polyamine containing food or beverage, characterized in that the genus is also provided a raw material or to animal and plant Camellia (Camellia) tea leaves, adding a salt solution to extract the extracted stem polyamine a method for producing thereof; a salt selected from sodium chloride, magnesium chloride and calcium chloride; the starting material is selected from animal and plant salmon roe, liver, wheat germ, soybeans, natto, oolong tea, black tea leaves, tea brick, black beans , persimmon leaves and green tea.


The collection of whole blood samples on paperboard, known as dried blood spot (DBS),offers a number of advantages over conventional blood sampling.DBS requires a smaller blood volume and reduces the number of laboratory animals.It simplified sample collection,storage,shipment,and processing.To date,DBS-LC-MS/MS has emerged as an important method for quantitative analysis of small molecule drugs.It will get more and more applications in pharmacokinetic studies.This paper summarizes the collection,storage, pretreatment,and analysis for DBS samples.


The Commission for Health Improvement (CHI) has been assigned the formidable challenge of auditing the implementation of National Service Frameworks (NSFs; [Department of Health, 1997][1]). The coronary heart disease NSF will be reviewed first, and this is likely to be followed by the mental health


This chapter applies theoretical insights around misrecognition to better understand the intersection of misinformation and ideology in the United States. It argues that misinformation practices are products of modernity. American modernity is characterized by contradictions between its basic social forms such as the money form, the commodity form, and so on. The contradictions create a bind for rulers. On the one hand, these contradictions mean that their rule is never stable. On the other hand, acknowledging the contradictions risks courting redress that also threatens their minority rule. Due to the imperative to mystify these contradictions, social problems are subsequently treated as anomalies or otherwise externalized; they can never be features of the capitalist political economy itself. Misinformation is a common by-product of this externalization as the capitalist ruling class uses it to weld together pacts and alliances that preserve the social hierarchy. The chapter outlines the broad argumentation offered by securocrats, reactionaries and technologists on Russia-gate. It takes a look at the proof put forward, the ethical reasoning invoked and the emotive appeals employed. It also looks at why these explanations fall short.


Waveform invariance is the basic principle of correlation sonar.A real-time testing system ba-sed on correlation for ultrasonic conductivity-gel is presented.This system is based on virtual oscillos-cope.It controls communication of the virtual oscilloscope through a USB port and is optimized with the multithreading tool of Windows.Several samples are tested,and the results analyzed.This system can steadily measure the sound velocity and attenuation of the conductivity-gel.


Automated theorem proving in first-order logic is an active research area which is successfully supported by machine learning. While there have been various proposals for encoding logical formulas into numerical vectors -- from simple strings to more involved graph-based embeddings -- little is known about how these different encodings compare. In this paper, we study and experimentally compare pattern-based embeddings that are applied in current systems with popular graph-based encodings, most of which have not been considered in the theorem proving context before. Our experiments show that the advantages of simpler encoding schemes in terms of runtime are outdone by more complex graph-based embeddings, which yield more efficient search strategies and simpler proofs. To support this, we present a detailed analysis across several dimensions of theorem prover performance beyond just proof completion rate, thus providing empirical evidence to help guide future research on neural-guided theorem proving towards the most promising directions.


In order to change the situation of the buildings within poor thermal performance and high energy consumption, effectual and energy-saving architecture structure is nowadays an active demand. As vernacular residence with low energy consumption is strong evidence on human beings long term adaption to local environment, traditional dwellings could be feasible conceptual design and optimization for modern architecture. The previous research seemed to demonstrate the perspective mentioned above. However, there might be some flaws. This paper, based on two former typical case studies, is aimed to reveal the deficiency of the field study and questionnaire, and the probability to improve the methodology.


Airlines deregulation is intended to remove state-sponsored protectionism, leading to economic liberalization so that entry conditions are easy and cheap, but the results were mostly disappointing. The research used a method of Structure, Conduct and Performance (SCP method). The results of this study indicate that the market structure of oligopoly is better than before deregulation. Conduct, there is price competition so tariff becomes cheaper. The performance of airlines is also getting better as shown by the increasing of production efficiency. Significant reversal of market share before and after deregulation of comparison between SOEs and POEs from 75.40%: 24.60% to 34.75%: 65.25%. Economic regulation by the government dilemma in addition to causing differences of views between the interests of producers and the interests of consumers, also the industry becomes more concentrated on the main players, and serves as a tool pricing and prevent entry of new competitors. Tribulation increased : increased number of flight delays, skyrocketing prices during busy times, the difficulty of getting tickets happens at the last minute and so forth, fewer airlines and routes, airport density.


A webshell is a command execution environment in the form of web pages. It is often used by attackers as a backdoor tool for web server operations. Accurately detecting webshells is of great significance to web server protection. Most security products detect webshells based on feature-matching methods—matching input scripts against pre-built malicious code collections. The feature-matching method has a low detection rate for obfuscated webshells. However, with the help of machine learning algorithms, webshells can be detected more efficiently and accurately. In this paper, we propose a new PHP webshell detection model, the NB-Opcode (naïve Bayes and opcode sequence) model, which is a combination of naïve Bayes classifiers and opcode sequences. Through experiments and analysis on a large number of samples, the experimental results show that the proposed method could effectively detect a range of webshells. Compared with the traditional webshell detection methods, this method improves the efficiency and accuracy of webshell detection.


Large amounts of pesticides are used annually, and in some cases, a part of the pesticide enters the water bodies by surface runoff to form long-term residues. In the recent past, the adverse effects of pesticides on the environment and human health received serious attention by the public and the competent authorities. Various conventional methods are used to remove these pesticides from water, but those methods are either costly or typical in operation. Therefore, adsorption is considered as an ecofriendly method. The adsorbent derived from biomaterial is considered an encouraging adsorbent due to its cost-effective and high adsorption capacity. In this chapter, detailed information on different types of pesticides, their metabolites, environmental concerns, and present status on degradation methods using adsorbents will be reviewed. This chapter presents a comprehensive overview on the recent advancement in the utilization of different adsorbents for the removal of pesticides. Overall, this study assists researchers to move forward in exploring a simple and economically viable technique to produce adsorbents with outstanding physiochemical properties and excellent adsorption capacity, so that the pesticides can be removed from aquatic ecosystem.


Increasing the octane number of combustion machines by adding some chemicals and studying the effect of these additives on the internal combustion efficiency of the machines taking the consideration of surrounding conditions are present in this reserch. Laboratory's conditions have directly affected to the physical properties of the fuel. After adding the chemical additives, gasoline have been inflow to the distillation unit to increase the efficiency and to identify the suitability of the additives with gasoline and their impact on internal combustion, as the difference between the two cases was observed. Different ratios were selected with a variety of chemicals such as methanol ethanol and AHA (belonging to the researchers and an unknown chemical formula) for the analysis of experimental data. The results showed the effect of additives the octane number and alteration in the physical properties of the fuel and at the same time on the properties of the engine. The results could be utalized to determine the chemical additives that increase the octane number and the efficiency of internal combustion of the machines as well as to determine the emissions of some gases. It is exposed that adding 2% of AHA to fuel have raised the octane number by 2.7 (3.09%) in warm areas, this ratio can be increased in cold areas. The analysis results data have done within the limits of global and environmental safety determinants.


Title:
The Perceived Influences of Managerial Activities on Intrapreneurship: A Case Study at IBM

Submission Date: 20th of May, 2016

Course: BUSN49: Degree Project, 15 ECTS, Spring 2016

Authors: Laura Reichartz & Lea Weinert

Supervisor: Mats Benner

Keywords: Intrapreneurship, Innovation, Sense-making, Management Systems

Purpose
We aim to unravel employees' understanding and perception of the managerial influences on intrapreneurship and which potential barriers they identify among mostly uncontrolled initiatives and formalized programs. From a theoretical perspective, our project aims to gain new insights into how managerial activities impact employees and their intrapreneurial behavior at IBM.

Research Questions
1. How do employees understand the influence of formalized activities (ifundIT, Intrapreneurship@IBM, etc.) on intrapreneurship?
2. How do employees understand the influence of open activities (an enabling culture, Connections, etc.) on intrapreneurship?
3. What are the perceived tensions of the intrapreneurship process of IBM?
Method
A research based on qualitative, hermeneutic methodology. Empirical material was collected with the help of nine interviews at our case company IBM. Interviews of semi-structured nature and aimed to explore the employees understanding and perceptions. Secondary data was collected with the help of literature and company internal data, available on the employees' platform IBMConnections.

Findings
Participants of this study do not dierentiate between open and formalized activities but rather highlight the importance of the combination of both. We found that intrapreneurs are largely intrinsicilly driven to innovate but also need the support of both an enabling culture and formalized programs that provide, e.g. funding. Participants further mentioned tensions such as a missing link between corporate orientation and actual implementation.

Contribution
We contribute to intrapreneurship literature by providing a deeper and more holistic picture of how employees are influenced by both open and formalized activities that management may engage in. Our main focus was that intrapreneurs need a combination of both supporting elements, where culture forms the basis and programs need to be ingrained.


In this contribution, an advance of the archaeological works carried out in Structure 4 at Machaquila during the field season of 2003 is presented. The works have recovered more than twenty stone fragments carved with hieroglyphs. The importance of these findings is relevant since other carved stones with hieroglyphs were recovered in this same structure in the sixties' (Graham 1967). The style of the carving and the existence of fragments matching up unequivocally suggest that the old findings and the new ones belong to the same glyphic text. The archaeological data, in combination with the epigraphic analisis of the text, now almost complete, will allow to know the function that this special building had in Machaquila, and to improve our knowledge about the dynastic history of this Maya kingdom by Late Classic times.


A neutral Ru(0)−alcohol complex, (η4-C4Ph4CO)(CO)2Ru(HOCHMe2) (7), was obtained by treating an acetone solution of (η4-C4Ph4CO)Ru(CO)3 (6) with aqueous Na2CO3 at room temperature, followed by acidi...


Development in Wireless LAN and Cellular technologies has motivated recent efforts to integrate the two. This creates new application scenarios that were not possible before. Vehicles with Wireless LAN radios can use other vehicles with both Wireless LAN and Cellular radios as mobile gateways and connect to the outside world. We aim to study the feasibility of such global connectivity from the road through simulation of the underlying connectivity characteristics for varying traffic and gateway densities. The connectivity results suggest that each vehicle should be able to connect to at least one gateway for a majority of time. The average path lifetimes are found to be good enough many traditional Internet applications like FTP and HTTP. The effectiveness of the AODV wireless ad-hoc routing protocol over this scenario is evaluated and shown to perform well for the densities considered. However, the routes created by AODV can break very frequently due to the dynamic nature of mobility involved. We introduce a couple of prediction based routing protocols to minimize these route breakages and thus improve performance. These protocols take advantage of some deterministic characteristics of the mobility model to better predict route breakages and take preemptive action.


A farmlet grazing trial at the Te Kuiti Research Area (20 km south of Te Kuiti) began in April 1983 to study the effects on production of reducing or withholding fertiliser over a 6-year period. The effects of withholding fertiliser are considered in this paper. The soils on which the trial was conducted are Mahoenui or Mangatea silt loams typical of 1.3 million ha of North Island hill country. Applications of 250 kg/ha/annum of superphosphate had been applied for 10 years before the trial began, leading to Olsen P tests of 14. In spite of moderate soil test levels, declines in both animal and pasture production where fertiliser was withheld were evident from year 2. By years 3-4 onwards, production declines of some 20-30% were evident. Effects on pasture composition where fertiliser was withheld were evident, with less white clover and more moss and weeds. No noticeable increase in scrub weeds or brush weeds occurred. Maintaining a high stocking rate (or stock pressure) was considered a dominant factor in this regard.


A series of a rigid meso-meso directly-linked chlorin-chlorin, chlorin-bacteriochlorin, and bacteriochlorin-bacteriochlorin dyads, including free bases as well as Zn(II), Pd(II) and Cu(II) complexes has been synthesized, and their absorption, emission, singlet oxygen ( 1 O 2 ) photosensitization, and electronic properties have been examined. Marked bathochromic shift of the long-wavelength Q y absorption band and increase in fluorescence quantum yields in dyads, compared to the corresponding monomers, are observed. Non-symmetrical dyads (except bacteriochlorin-bacteriochlorin) show two distinctive Q y bands, corresponding to the absorption of each dyad component. A nearly quantitative S 1 -S 1 energy transfer between hydroporphyrins in dyads, leading to an almost exclusive emission of hydroporphyrin with a lower S 1 energy, have been determined. Several symmetrical and all non-symmetrical dyads exhibit a significant reduction of fluorescence quantum yields in solvents of high dielectric constants; this is attributed to the photoinduced electron transfer. The complexation of one macrocycle by Cu(II) or Pd(II) enhances intersystem crossing in the adjacent, free base dyad component, which is manifested by a significant reduction in fluorescence and increase in quantum yield of 1 O 2 photosensitization. Graphical abstract Symmetrical and non-symmetrical meso-meso linked chlorin-chlorin, chlorin bacteriochlorin and bacteriochlorin-bacteriochlorin dyads, (free base and Zn(II), Pd(II) or Cu(II) complexes) are reported. For non-symmetrical dyads an efficient singlet-singlet energy transfer is observed. Insertion of heavy element [Pd(II) or Cu(II)] significantly enhances 1 O 2 photosensitization. Most of the dyads exhibit a significant reduction of the fluorescence in highly polar solvents, suggesting a charge transfer character of the excited state.


Signaling
Organisms must adapt their growth to changing environmental conditions, such as variations in nutrient access. In Drosophila , dietary amino acids promote the release of insulin-like peptides from the brain, which activate organismic growth. Delanoue et al. show that the peptide Stunted (


From the study of the dephosphorization of liquid iron by the Na2O-SiO2-Fe2O3 fluxes containing CaO, MnO2, or Al2O3 at 1600°C, the contributions of CaO, MnO, and Al2O3 on the phosphorus distribution between liquid iron and Na2O-MgO-FetO-SiO2 slaps were derived.The phosphorus distribution ratio and the equilibrium quotient were expressed by the following equations including the terms of (%CaO), (%MnO), and (%Al2O3). (i) log {(%P)/[%P]}=0.092{(%Na2O)+0.8(%CaO) +0.6(%MnO)-0.9(%Al2O3)}+2.5log(%T.Fe) -3.54 (1600°C) (ii) log[(%P2O5)/{[%P]2•(%FetO)5}]=8.87log{(%Na2O) +0.1(%MgO)+0.7(%CaO)+0.6(%MnO) -0.9(%Al2O3)}-14.94 (1600°C)The activity coefficients of P2O5 and FetO were expressed in terms of the mole fraction of the slag components, and the effects of CaO, MnO, and Al2O3 on these activity coefficients were investigated.The relationship between phosphate capacity and theoretical optical basicity for the Na2O-based slags containing CaO, MnO, or Al2O3 was examined and compared with that for the CaO-based slag. The phosphate capacities of these slags could not be represented uniquely by the theoretical optical basicity. Furthermore, the manganese distribution observed in this experiment was analyzed and compared with that reported for the CaO-based slag.


The present invention relates to a ballast water electrolytic treatment system using an improved side stream pipe. The ballast water electrolytic treatment system comprises: a main stream pipe; a draw-out pipe communicatively connected to the main stream pipe to draw out ballast water flowing in the main stream pipe; an electrolytic bath connected to the end of the draw-out pipe to receive the ballast water and generating sterilized water by electrolyzing the received ballast water; and a supply pipe for supplying the sterilized water generated from the electrolytic bath to the main stream pipe. The draw-out pipe can draw out the large amount of the ballast water even using a draw-out pump having the same capacity by comprising an inlet part formed in the opposite direction to the flowing direction of the ballast water flowing in the main stream pipe to allow the ballast water to enter therein. The supply pipe can increase the mixing efficiency of the ballast water and the sterilized water by comprising an outlet part formed in the same direction as the flowing direction of the ballast water flowing in the main stream pipe to spray the sterilized water to the main stream pipe.


Previous research on breakthrough innovations has used patent data to identify them and assess their impact. The main proxy for breakthroughs uses forward citation counts, where patents at the top ...


Arc magmatism and megathrust earthquake occurrence in a subduction zone are deemed to attribute to many factors, including structural heterogeneities, fluid contents, temperature, depth of subducting oceanic crust, and etc. However, how these factors affect them is unclear. The extensive arc magmatism observed on the island arcs is considered to be an indicator on chemical exchange between the wedge mantle and the surface in a subduction zone. Megathrust earthquake frequently occurrence is also considered to be attributed to the slab melting and associated interplate coupling of the subducting plate. The Western Pacific subduction zone is regarded as one of the best Laboratory for seismologists to examine these processes due to the densest seismic networks recording numerous earthquakes. Some of the previous studies suggest that the island-arc magmatism is mainly contributed to the melting of peridotite in the mantle wedge due to fluids intrusion from the dehydration process associated with the subducting oceanic crust. They further argued that the oceanic plate could only provide water to the overlying mantle wedge for arc magmatism, but not melt itself due to that it is too cold to melt at a depth between 100 and 200km. However, some of other studies revealed that the hydrated basalt derived from the mid-ocean ridge will be melted with high T and water saturated on the upper interface of the sbuducting plate in the mantle wedge. We consider that the three-dimensional (3-D) P- and S- wave velocity (Vp, Vs) and Poisson’s ratio (σ) structures of the subduction zone, synthesized from a large-quantity of high-quality direct P-, and S-wave arrival times of source-recive pairs from the well located suboceanic events with sP depth phase data could provide a compelling evidence for structural heterogeneity, highly hydrated and serpentinized forearc mantle and dehydrated fluids in the subduction zones. In this study, we combined seismic velocities and Poisson’s ratio images under the entire-arc region of the Western Pacific subduction zone to reveal their effects on megathrust earthquake generation and arc magmatism. We find that a ~10 km-thick low-velocity layer with high-V and high-Poisson’s ratio anomalies is clearly imaged along the upper interface of the subducting Pacific slab. This distinct layer implies partial melting of the oceanic crust due to the deep-seated metamorophic reactions depending on the source of fluids and temperature regime. Such a process could refertilize the overlying mantle wedge and enrich the peridotite sources of basalts under the island arc. Significant low-V and high-Poisson’s ratio anomalies were observed in the mantle wedge along the volcanic front, indicating melting or partial melting of peridotite-rich mantle and then yield tholeiitic magma there. The present study demonstrates that the combined factors of fluid content, mineral composition and thermal regime play a crucial role in both slab melting and arc-magmatism under the Western Pacific subduction zone.


Backgrounds: Carrot pomace is a by-product of the juice industry, which quickly spoils due to its high moisture content and is usually considered waste. However, it is a valuable product containing a significant amount of bioactive compounds, particularly carotenoids.Context and purpose of this study:In this study, we aimed to develop a technology for obtaining carrot powder from carrot pomace with an increased availability of beta-carotene. The unique aspect of the technology involved the use of enzymatic and impact-disintegration-activation processing (IDAP) of the raw material to enhance the release of beta-carotene from plant cells.Objective of this study:To achieve the goal, we have set objectives to compare various dosages of enzyme preparation and to evaluate devices for grinding carrots that can be used to make powder. At all stages, it was necessary to measure the amount of beta-carotene in the samples.Results: It has been found that the yield of carotenoids from carrot pomace is 185% higher compared to whole carrots. Moreover, the application of enzymatic and impact-disintegration-activation processing significantly increases the carotenoid yield in the powder by 17 times compared to carrots (200% in terms of dry matter). This remarkable result was achieved through the described processing method and the selection of the enzyme preparation. Additionally, the mechanoactivation obtained by using the Desi-15 disintegrator played a crucial role. It was also observed that the use of impact-disintegration-activation processing for further grinding of dried carrots can increase the beta-carotene yield by 8 times. Conclusions: The carrot pomace was processed, resulting in a fine-dispersed carrot powder that shows promising applications in the food      or agricultural industries.Keywords: Carrot pomace, beta-carotene, impact-disintegrator-activator processing (IDAP), enzymatic processing, pectolytic enzyme preparations


ABSTRACT. For an optimal health a good oral equilibrium is required. A balanced diet comprising of diverse and healthy foods is key to promoting good oral health, limitation of high carbohydrates intake should be taken into consideration. Diet affects oral health in many ways such as diet include dental caries, developmental defects of enamel, dental erosion and periodontal disease and this situation could affect general health in many ways like cardiovascular and infectious diseases.


Many quad encoding technique have been published previously, using a variety of approaches to the different facets of quad storage, representation and manipulation. We review the major classes and identify three parameters which distinguish them. These are then used explicitly to classify a large number of published methods, with short discussion on each. In doing this we are also able to highlight some new approaches, to identify rare examples which escape the classification, and to suggest approaches to choosing a method to suit a given application.


As researchers bag more and more of the genes at fault in hereditary diseases, sickle cell anemia stands as a sobering reminder that just identifying a mutant gene doesn9t necessarily mean the problem is solved. The mutation that causes this disease has been known for 50 years, yet there is no cure and few effective treatments. But on pages
 873
 and
 876
 of this issue, two research teams report that they have created mouse models of sickle cell anemia that closely mimic the human disease. Researchers say the new mice will be "indispensable" for testing drug and gene-therapy strategies for controlling the disease.


Diffuse large B-cell lymphoma (DLBCL) Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non- Hodgkin lymphoma that develops from the B-cells in the lymphatic system. Under the microscope, large malignant lymphocytes are seen diffusely throughout the specimen. Diffuse Large B-Cell Lymphoma (DLBCL) accounts for 20– 30% of all lymphoid malignancies. This subtype forms distinct morphological, molecular, and phenotypic variants. Therefore, it is of a great value to classify diffuse large B-cell lymphoma according to gene expression profiling into germinal center B-cell subtype, activated B-cell subtype, and unclassified subtype. The outcomes vary between these subtypes, and the germinal center B-cell subtype has a better outcome with the current standard rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (R-CHOP) immunochemotherapy.


This paper examines the possibilities of producing electricity and heat using renewable energy in Romania. Total energy demand in 2030 will be around 50% higher than in 2003 and oil will be around 46% higher. Known oil reserves could sustain current levels of consumption only until 2040, and the natural gas until 2070, while world coal reserves provide a period of more than 200 years even in an increase in operating . European Commission (EC) considered essential for the EU to promote a common energy policy based on energy security, sustainable development and competitiveness.


In spite of the progress made in the field of image denoising, it's still an open issue. In fact, a natural image is a mixture of texture, structure and noise and this makes the task of filtering crucial mainly when it deals with texture preserving. In this report, we present a novel adaptive filtering technique based on a partition of the image to "noisy smooth zones" and "texture + noise" zones. To this end, an analysis of local features, is used to recover a statistical model that associates for each pixel a probability measure corresponding to its membership degree to each class. This probability function is then encoded in the filtering process leading to encouraging results where a good compromise between noise suppression and texture preserving is reached. Experimental results demonstrate the potentials of our method.


The paper is devoted to the history and prospects of gene therapy, a new area of biotechnology that holds great promise for the treatment genetic disorders, cancer and dangerous infections such as HIV and hepatitis B. A brief history of gene therapy is described. The paper discusses the main lines of research in this area as well as the mechanisms, approaches, and techniques employed by gene therapy, and the examples of the experimental and clinical use of genetic constructs. Another important research area closely associated with gene therapy is the use of computer modeling and simulation. The paper also touches upon the ethical concerns surrounding this field of biomedicine, including its affordability and accessibility for patients.


Preference settlement is a person's willingness to live or not in a place that influenced by various factors and variables. The policy of housing development in the suburban is an attempt to divert the population in Medan City to the peri-urban area. This causes more people to choose the peri-urban area as a residential location. Based on observations, the location in Medan City with the amount of housing that tends to increase is Namorambe District. This research is analyzed based on the following variables: accessibility, environmental conditions, and the completeness of facilities and infrastructure. This research aims to examine the physical factors that become settlement preferences in peri-urban areas. The method used in this research is quantitative descriptive by grouping data that have similarities with each other. The results of the research showed: in terms of accessibility, the large number of streets and the availability of many alternative routes; in terms of environmental factors, the condition of residential street frame, drainage systems, the vegetation, and the cleanliness of the; in terms of the condition of the facilities and infrastructure, the electricity facilities, garbage disposal, the sanitation network and worship facilities are the reasons respondents choose to live in Namorambe District.


The processes of thinning GaAs substrate is one of the most important processes in fabrication of multiple quantum well infrared photodetector,especially for focal plane array(FPA).Through thinning GaAs substrate by using both manual and machine methods,the thickness of GaAs substrate is decreased from 625 μm to 29±2 μm.By analyzing the experimental result,the reasons for perpendicular incidence inducing light absorption is discussed.


Distributed channel estimation (DCE) is one of the core research topics in wireless sensor networks (WSNs). Under the hypothesis that channel parameters can be modeled as a sparse system, DCE based on compressed sensing (CS) is an effective approach to channel estimation. Among all the existing CS-DCE schemes, every node must store a sensing matrix whose size will increase with the number of channel parameters. Hence the workload of each node increases. To overcome this problem, in this paper, the CS-DCE scheme is developed with Semi-tensor product (STP) to relieve every sensor's storage space and reduce its computation complexity. Simulation results show the proposed framework releases the sensor's workload and ensures the reconstruction accuracy.


This article presents findings of a study to determine attitudes of American teachers enrolled in graduate human relations and supervision and teacher evaluation courses taken as part of a program preparing them to become school administrators. They were given instruction on the New Bloom's Taxonomy and asked to consider the Bill of Rights for the Planet as a possible catalyst for the teaching of creativity; they were then asked to provide their re-actions to these guiding research questions: 1) To what extent are currently mandated or suggested curriculums allowing the teaching of creativity in their respective grade levels or subjects? and 2) How would they assist teachers under their supervision, once becoming administrators, to structure local curriculums and lessons to include the teaching of creative solutions to issues? Sub-research questions included: 1) How would you define creativity in teaching? 2) What do you consider to be barriers to creativity? and 3) As a future school administrator, what do you anticipate you will do to enhance creativity in your building? Based on their responses to the previous mentioned prompts, it was concluded that teachers are not using creativity to a high level in their currently mandated or suggested curriculums. There was strong indication that these future administrators felt that it was part of their responsibility to make sure their teachers used creativity in the classroom. To have creativity there needs to be a foundation to build upon and the willingness of teachers to accept more than one answer for a problem.


Dreamy alt / lo-fi rockers PILLOW TALK Memphis have premiered a video for their track Ferris & Effie, coming off their upcoming Animal Style ...


This paper deals with the characteristics of real vibrational power flow in a simply supported rectangular panel under the action of feedforward vibration control. It is found that the path of the power flow is a combination of translations and rotations, the rotations induced by the interference of two modes which products a ''vortex generating block.'' Particular emphasis is placed on the vortex power flow in the vibration intensity field. A qualitative formula for predicting the number of power flow vortices, as well as the discussion of the vortex period, is put forward. Then, by introducing an energy stream function, the generation mechanism of the vortex power flow is quantitatively discussed. The fundamental characteristics of the vortex power flow are further clarified by vortex function derived from the intensity field. A novel method to induce a vortex at an arbitrary location of the plate is also shown, which may have practical applications in controlling the path of vibrational power flow in s...


Abstract: Machine learning is the buzz word right now. With the machine learning algorithms one can make a computer differentiate between a human and a cow. Can detect objects, can predict different parameters and can process our native languages. But all these algorithms require a fair amount of processing power in order to be trained and fitted as a model. Thankfully, with the current improvement in technology, processing power of computers have significantly increased. But there is a limitation in power consumption and deployability of a server computer. This is where "tinyML" helps the industry out. Machine Learning has never been so easy to access before!


In an age of information overload, we are faced with seemingly endless options from which a small number of choices must be made. For applications such as search engines and online stores, Recommender Systems have long become the key tool for assisting users in their choices. Interestingly, the use of Recommender Systems for recommending scientific items remains a rarity. One difficulty is that the development of such systems depends on the availability of adequate datasets of users' feedback. While there are several datasets available with the ratings of the users for books, music, or films, there is a lack of similar datasets for scientific fields, such as Astronomy and Life and Health Sciences. To address this issue, we propose a methodology that explores scientific literature for generating utility matrices of implicit feedback. The proposed methodology consists in identifying a list of items, finding research articles related to them, extracting the authors from each article, and finally creating a dataset where users are unique authors from the collected articles, and the rating values are the number of articles a unique author wrote about an item. Considering that literature is available for every scientific field, the methodology is in principle applicable to Recommender Systems in any scientific field. The methodology, which we call LIBRETTI (LIterature Based RecommEndaTion of scienTific Items), was assessed in two distinct study cases, Astronomy and Chemistry. Several evaluation metrics for the datasets generated with LIBRETTI were compared to those derived from other available datasets using the same set of recommender algorithms. The results were found to be similar, which provides a solid indication that LIBRETTI is a promising approach for generating datasets of implicit feedback for recommending scientific items.


The number of wireless users, applications and network access technologies is constantly growing. This trend supports the vision of pervasive computing where users have network access anytime and anywhere. Furthermore applications become location-sensitive and context-aware. Wireless LAN technologies are the ideal mechanism for extension of network connectivity to public places (such as airports, shopping centers, hotels, parks) and introduction of location and context-aware applications. Traditional WLAN user positioning techniques include the strongest WLAN access point and RF fingerprinting methods. In this paper an enhancement of triangulation method with RF propagation loss algorithm is proposed and compared with traditional methods. All evaluations are based on experimental results in real WLAN environment. Experimental results confirm the advantages of the proposed method.


This chapter considers a fundamental problem which is central to Søren Kierkegaard and Martin Heidegger, namely how to avoid living a life that is governed by others and so is inauthentic, trapped within the hum-drum and the mundane—a life in the crowd. Focusing first on Kierkegaard, and his critique of 'busyness', it then turns to Heidegger, and his account of 'idle talk'. However, it is argued that Kierkegaard's approach differs from Heidegger's in being fuelled by an ethical passion, which is partly driven by his hostility to Hegelianism, and also to contemporary Danish Christendom. Moreover, while on Heidegger's account, life in the crowd is made an inevitable and therefore neutral feature of human existence, for Kierkegaard it can be avoided. How this might be possible for Kierkegaard is considered in subsequent chapters.


Pulmonary tuberculosis (TB) and diabetes mellitus (DM) are still health burden diseases in the developing and poor countries. Since the 20th century, clinicians have observed an association between DM and TB, but the strength of the relationship between DM and TB in low-income countries are still unclear.The aim of this research is to identify the relationship between DM and impaired glucose tolerance with a history pulmonary tuberculosis grown in Indonesia. Design of the study was a cross sectional using secondary data from Riset Kesehatan Dasar (Riskesdas), National Institute of Health Research and Development 2013. The results showed that respondents were diagnosed with diabetes has nothing to do with the history of TB. However, if diagnosed glucose intolerance likely to undergo pulmonary tuberculosis by 42% or 1.4 times compares to the odds that respondents with normal blood glucose (OR 1,36; 95% CI 1,06-1,61 p<0,05). As an effort to prevent the increasing prevalence of pulmonary tuberculosis, need to be screened for TB in people with diabetes mellitus or glucose intolerance, particularly those living in areas of high TB prevalence.


As the 2014 FIFA World Cup tournament approaches, online entrepreneurs in China have been offering solutions to a common problem facing football fans in the country: how to get around the 11 hour time difference between Beijing and Rio de Janeiro, meaning that games will air between midnight and 6 am Beijing time.

The answer? Simply buy a sick note online, …


Patterns of nucleic acid,total sugar, reducing sugar, dissolved phosphorus, amino nitrogen,pH and dissolved oxygen (DO) were determined for Bt fermentation. The figure of nucleic acid curve was almost the same as that of a typical Bt growth curve.The peak value of nucleic acid was varied according to medium concentrations. So,cell count could be estimated by nucleic acid content of beer. The residual sugar of two kinds of media at harvest was 62.75% and 66.6% Respectively. It showed that carbon sources supplied were sufficient for Bt growth.But DO and dissolved phosphorus were decreased to a very low level during log phase.It indicated that adjusting DO and phosphorus concentration to a proper level could be closely related to the increase of cell count


The thermo-mechanical performance of extruded wheat starch/flour containing different additives was examined via microwave-heated thermo-mechanical analysis. Additionally, the dielectric property of the wheat starch-based materials was also studied using a microwave calorimeter. It has been found that when glycerol or polyvinyl alcohol was used as single additive in wheat starch, a content limit existed and using the additives at a concentration higher than the limit will lead to deterioration of the material's microwave foamability. A good initial thermal expansion is essential for a proper foaming of the wheat starch-based materials; however, high enough dielectric loss factor (ɛ″) is also required for the formation of foam structure under microwave radiation. Glass transition temperature (Tg) for the extruded wheat starch materials was detected by microwave thermo-mechanical analysis at about 75–95°C when heated at 15°C/min; and for the foamable formulations, the foaming temperature (Tf) is generally 10–20°C higher than the corresponding Tg. Impurities like proteins play important roles in the microwave foaming of extruded wheat flour. Overall, the extruded wheat flour with additives is more difficult to foam under microwave heating than the wheat starch extruded from the similar formulations.


Background and Objective: There are critical areas in the mandible that should be considered during implant placement such as inferior alveolar canal, mental foramen, and the root of the adjacent tooth. Two-dimensional images obtained from periapical, panoramic, and conventional tomography are considered in the evaluation of implant placement and bone quality. Cone-beam computed tomography (CBCT) is a new imaging technique, which is superior to other methods from different aspects. Thus, we aimed to compare the accuracy of two different CBCT systems (i.e., Promax 3D and Newtom 3G) in measuring the anatomic distances in the mandible. Materials and Methods: In this experimental study, six dry mandibles were used for measuring the width and height of mandible in six areas. Also, caliper was used as the gold standard and the distances were marked by barium sulfate as a radiopaque material. Then, the mandibles were scanned with the two CBCT systems, and the distances were measured by two observers (oral and maxillofacial radiologists) under homogenous conditions by using their respective software. The obtained results were evaluated by multivariate ANOVA and compared with the gold standard. Results: The accuracy of both CBCT systems (in all the three FOVs) was close to that of collies in measuring the height of mandible. The accuracy of Promax 3D was closer to collies in evaluating bacco-lingual width, and it was more accurate than Newtom 3G (in all the three FOVs; P<0.001). Thus, the accuracy of Promax system is close to the gold standard in the evaluation of the mandible height and bacco-lingual width. Conclusion: The results of this study showed that Promax 3D and Newtom 3G techniques (in all the three FOVs) have millimeter precision and are capable of measuring the lengths and widths needed to establish the


We propose a new semi-norm named luminance constrained total variation (LCTV) to utilize a correlation and an imbalance of information amounts between luminance and chrominance for solving image recovery problems. As an example of LCTV application, we also propose a method for restoring chrominance components of JPEG 2000 compressed images. We cast this method into an ℓ1 (LCTV)-ℓ2 combined optimization problem. The algorithm to solve this optimization problem by using variable splitting is also proposed and its convergence is confirmed. Experimental results show our proposed optimized decoding method outperforms the existing state-of-the-art denoising methods.


For imaging radars, the calibration effort increases with higher frequency and finer angular resolution demands and is therefore one of the largest cost factors in radar production. In case of high angular resolution, the calibration is also sensitive to array misalignment, resulting in costly calibration procedures. This paper proposes an angle-dependent radar calibration method with significantly reduced calibration effort. The high efficiency and robustness against misalignment is achieved by exploiting phase symmetry of a target in the measured radar response. Based on an initial theoretical formulation followed by an experimental verification, this novel approach does not only yield a cost-effective calibration, but also increases the robustness against array misalignment.


Background: Although the contribution of platelets to the measured serum EGF levels was reported by Oka since 1983, the majority of reports in healthy donors or patients do not control clotting times during the collection of the sera. This results in a variation of the notified values, additionally to the one already caused by the functional EGF SNP of the gene, that modulates the expression of the molecule. Both issues -platelets and SNP- make the conventional stratification by absolute serum EGF levels not suitable. Within this study we evaluated serum EGF levels in a panel of 105 healthy Cuban donors, balanced by gender and age (from 18-78 years). As a result, a new stratification methodology for the comparison between individuals was proposed.
Methods: The EGF was estimated in sera collected at two different clotting times: 1h and 4h. Comparisons between groups were carried out. The estimations, normalized through the calculation of ratios from the two measured levels (r=[EGF]1h/[EGF]4h), were used for the stratification.
Results: Differences were found by age (4h, donors younger and older than 45 years, p=0.0083) and gender (1h, p=0.0167), and between 1h and 4h levels (p<0.0001, n=105). While 38 out of 105 individuals ranked different in 1h and 4h conventional stratifications, the methodology using ratios yielded a unique score for each individual.
Conclusions: The proposed methodology of stratification by ratios, in contrast to the conventional approach, allows for a proper comparison between EGF levels and individuals. Thus, it should have an impact on diseases for which the association of EGF with the illness has been established, aiding to clarify the connection of the molecule with the disease. This work might be of value to clinicians, scientists, and the healthcare community in general, conducting research regarding the role of EGF as a biomarker.


Since operating conditions of power systems always change, the input and output signals of wide-area damping controller (WADC), which are selected at an operating point, may not be able to guarantee the damping effect at other operating points. This paper focuses on a new adaptive signal selection for WADC against several operating conditions, such as various load demands, control signal failure, line and generator outages, and effect of communication latency. The joint controllability and observability is used to determine the best input and output pairs of WADC at any operating points. Small-signal and transient stabilities study in the IEEE 50-machine system including renewable sources, i.e., wind and solar photovoltaic generators are conducted to evaluate the effect of the proposed method. Study result demonstrates that the WADC with the adaptive signal selection yields superior damping effect to the WADC with the fixed signal selection over wide range operations.


Multi-pattern matching algorithms play a key role in the intrusion detection. The two classical pattern matching algorithms are researched, and an improved WU-MANBER algorithm is used in the intrusion detection. The experiment showed that the improved WU-MANBER algorithm is about 20% fewer in matching number than AC-BNFA algorithm, and the number of CPU operation cycle reduce 20%.


Separated protein bands are sequentially electrophoresed into low melting agarose plugs distributed in an apparatus of original design along the surface of a plastic drum. The rotation of the drum is synchronized to migration of electrophoretic bands to receive each band individually. Agarose plugs are dissolved enzymatically for transfer into the mass spectrometer. One μL of the agarose solution containing 1 pmol of each of three lithium and natrium salts of dodecyl sulfate (Li‐Na‐DS)‐proteins were applied to matrix‐assisted laser desorption/ionization‐mass spectrometry (MALDI‐MS) without any prepurification. It yields a signal indistinguishable from that obtained in the absence of agarose.


The research has five proposed: 1) to describe personal mastery of leadership in english departement at STKIP PGRI Ngawi, 2) to desribe mental methods of leadership in english departement at STKIP PGRI Ngawi, 3) to describe shared vision of leadership in english departement at STKIP PGRI Ngawi, 4) to describe system thinking of leadership in english departement at STKIP PGRI Ngawi. 5) to describe team learning of leadership in english departement at STKIP PGRI Ngawi. The skill is descripƟve qualitaƟve research; study case. The source of the data research from the chairman, lecture and students. The result of the research shows that are: 1) personal mastery: a) commitment; personal and a shared commitment, b) creativity, innovative and priorities; good creativity, innovative and priorities. 2) mental methods: a) criticism and suggestions; received and evaluated of the criticism and suggestions, b) Behavior; discipline, responsible and friendly. 3) Shared vision: a) motivation and oppeness; good motivation and slightly open, b) Vision; shared vision. 4) systems thinking has not been so appears. 5) Tim learning: a) position; the position isn't an obstacle to maintain good relations between the others, b) dialogue and discussion; to improve communication.


Planning with ClosedLo op Macro ActionsDoina PrecupUniversityof MassachusettsAmherst MA http wwwcsumassedu dprecupRichard S SuttonyofMassacttp wwwcsumassedu ricSatinder Singhy of ColoradoBoulder CO ttp wwwcscoloradoedu bavejaAbstractPlanning and learning at multiple levels of temp oral abstraction is a key problem for articial intelligence In this pap er we summarize an approachtothis problem based on the mathematical frameworkof Markov decision pro cesses and reinforcement learning Conventional mo delbased reinforcement learninguses primitive actions that last one time step and thatcan b e mo deled indep endently of the learning agentThese can b e generalized tomacro actionsmultistepactions sp ecied by an arbitrary p olicy and a wayofcompleting Macro actions generalize the classical notion of a macro op erator in that they are closed lo opuncertain and of variable duration Macro actions areneeded to represent commonsense higherlevel actionssuch as going to lunch grasping an ob ject or traveling to a distantcity This pap er generalizes prior workon temp orally abstract mo dels Sutton and extends it from the prediction setting to include actionscontrol and planning Wedene asemantics of mo dels of macro actions that guarantees the validityofplanning using such mo dels This pap er presentnewresults in the theory of planning with macro actionsand illustrates its p otential advantages in a gridworldtaskIntro ductionThe need for hierarchical and abstract planning is afundamental problem in AI see eg Sacerdoti Laird et al  Korf  Kaelbling  DayanHinton Mo delbased reinforcement learning oers a p ossible solution to the problem of integrating planning with realtime learning and decisionmaking Peng  Williams  Mo ore  Atkeson Sutton  Sutton  Barto  Howeverconventional mo delbased reinforcement learning usesonestep mo dels that cannot represent commonsensehigherlevel actionsMo deling such actions requiresthe ability to handle dierent interrelated levels oftemp oral abstractionSeveral researchers have prop osed extending reinforcement learning to a higher level by treating entireclosedlo op p olicies as actions whichwe callmacroactionseg Mahadevan  Connell  Singh Hub er  Grup en  Parr  Russell p ersonal communication Dietterich p ersonal communication McGovern Sutton  Fagg  Each macro action issp ecied by a closedlo op p olicywhich determines theprimitive actions when the macro action is in forceand by a completion function which determines whenthe macro action ends When the macro action completes a new primitive or macro action can b e selectedMacro actions are like AIs classical macro op erators in that they can takecontrol for some p erio dof time determining the actions during that time andin that one can cho ose among macro actions muchasone originally chose among primitive actions Howeverclassical macro op erators are only a xed sequenceof actions whereas macro actions incorp orate a general closedlo op p olicy and completion criterion Thesegeneralizations are required when the environmentissto chastic and uncertain with general goals as in reinforcement learning and Markov decision pro cessesThis pap er extends an approach to planning withmacro actions intro duced by Sutton  based onprior work by Singh  Dayan  and by Sutton and Pinette   This approach enables mo dels of the environment at dierent temp oral scales tobe intermixed pro ducing temp orally abstract mo delsSutton  Dayan  and Sutton and Pinette  were concerned only with predicting the environment in eect mo deling a single macro action LikeSingh  we mo del a whole set of macro actionsand consider choices among them but the extensionsummarized here includes more general macro actionsand control of the environment Wedevelop a generaltheory of mo deling and planning with macro actionsTo illustrate the kind of advance we are trying tomake consider the example task depicted in Figure


Conventional drilling of composites always results in fiber delamination and tear,as a new borehole processing method,orbital drilling has many advantages for composites processing.Considering the practical processing condition in aircraft assembly site,one drilling system including robot as moving carrier,orbital drilling terminal actuators as processing unit and orbital drilling tool was established.The orbital drilling parameters orthogonal test of carbon fiber reinforced plastics(CFRP)was carried out based on this system,and the effects of tool spindle speed,feed per tooth and axial feed depth on cutting force were deeply analyzed.With the defects inspection results,the relationship between cutting force and defects,such as delamination and tear,were investigated.At last,the optimal set of process parameters was obtained.It is verified that thrust force decreases more than 26%after optimation and there are hardly tear and burr formation around the hole exit and entrance,which indicates a better machining quality.


The article demonstrates the application of convex combinations in determining the center of scalar quantity on a finite set. The same procedure can be applied to countable sets. The observing is extended to sets with uncountable number of points, more specifically, to sets with positive volume. In this continuous case, the barycenter of quantity function is defined using the integral method with convex combinations.


One of the main challenges that governments face is managing scarce resources to attend society's needs. To achieve this, among other actions, they have developed initiatives that allow the coordination of technologies, people, processes and structures; however, these actions have had a short-term vision and low impact rates.To determine the current situation of knowledge management in the Colombian public sector, a literature review was carried out to identify barriers of initiatives from the international context, detect Colombian initiatives and characterize the scientific documentation of the country related with knowledge management.As a result, in Colombia and other emerging economies, knowledge management actions are rarely documented and developed from the scientific and research literature, evidencing the absence of guidelines and guidance tools to create and manage knowledge management initiatives. This delay is attributed to the fact that, in the private sector, it is not considered a strategic issue, and, the academic focus on conceptual approach, research the importance of formulating strategies and the needs of finding an adequate model.It is emphasized that the implemented approach is related to the use of information technologies, leaving aside the importance of human interaction to create, transfer and appropriate knowledge. The identified Colombian initiatives are from the MinTIC and non-financial public companies, which have focused on the implementation of knowledge management tools and practices and the creation of specialized equipment.In conclusion, from the international perspective, where innovation is sought to be implemented as a response mechanism to the demands of current citizens, in Colombia there are significant delays in the development and documentation of knowledge management initiatives. Also, although there is a growing interest in the implementation of KM models in the public sector, but they can't achieve be materialized because there are no guidelines or processes for the creation of models that facilitate the transfer of knowledge.


Here we describe a mutation in the mitochondrial complex I assembly factor (Evolutionarily conserved signalling intermediate in Toll pathway) ECSIT which reveals tissue specific requirements for this factor in complex I assembly. Mitochondrial complex I assembly is a multi-step process dependant on assembly factors that organise and arrange the individual subunits, allowing for their incorporation into the complete enzyme complex. We have identified an ENU induced mutation in ECSIT (N209I) that exhibits a profound effect on complex I assembly only in heart tissue resulting in hypertrophic cardiomyopathy in the absence of other phenotypes. Mitochondrial function was reduced by 98% in mitochondria isolated from cardiac tissue but mitochondria from other tissues such as skeletal muscle, brain, liver, and kidney were unaffected. This data suggests the mechanisms underlying complex I assembly are tissue specific and has implications in understanding the pathogenesis of cardiomyopathy.


We discuss our development of a decision model that allows La Poste, the French national postal operator, to assess the cost benefits of merging the urban mail and parcel delivery networks, which were run previously as separate entities. Our model, based on a mixed-integer linear program, derives the optimal network structure, including direct delivery, indirect delivery, or a hybrid structure, and provides an approximation of its routing cost. This approach allows us to model realistic large-scale problems. Based on data from the French city of Nantes, we find that merging the mail and parcel delivery networks yields cost benefits of approximately three percent, an amount that proves to be robust under various scenarios we tested. These findings corroborated La Poste management's expectations of potential cost savings and led to management's decision to create a new organizational structure in which local managers are responsible for the urban delivery of domestic mail and parcel.


A particle-scale surface tension force model (STF) is proposed here to be incorporated in the smoothed hydrodynamics particle (SPH) method. This model is based on the identification of interface geometry and the gradient of densities across the interface. A square bubble of single-phase and a square bubble immersed in fluids are simulated by the STF model accompanied with a combined kernel in SPH to validate their suitability to simulate the immersed bubble motion. Two cases of rising bubbles, i.e., a single rising bubble and a pair of rising bubbles, are simulated for demonstration. The rising velocity, density, surface tension force, interfacial curvature, the power of the STF, and the smoothing length of the rising bubble and surrounding fluids are all computed by the current STF model to study the characteristics of immersed bubble's motion and coalescence. The current model provides a way to capture the interfacial interactions in two-phase flows at particle scales.


—The purpose of this manuscript is to present a reliable estimate of the Muslim population and its percentage in each country throughout the world from 1950 to 2020. This data is summarized to be a reference for other studies and discussions related to the Muslim population. The presented data show that the percentage of the World Muslim population with respect to the total World population has increased


The use of traditional marketing research techniques in an international context suffers from two potentially fatal flaws: the over-reliance on purely quantitative data and through the use of rigidly structured approaches to primary data collection, the inability to gather information on problems/issues not thought of in advance by the developers of the survey instrument(s). A means of overcoming these problems is through the use of "real-lime" marketing research activities; activities targeted at checking and challenging marketplace assumptions. A "real-time" approach to international marketing research as described and contrasted with traditional marketing research techniques. A specific approach to this type of research currently being implemented by an institutional investment company is presented. Managerial guidelines are then given for the consideration, development, and implementation of a "real-time" approach to international marketing research by service companies.


The appropriate deployment of technology contributes to the improvement in the quality of healthcare delivered, the containment of cost, and to increased access to services offered by the healthcare system. Over the past one-hundred years, the dependence of the healthcare system on medical technology for the delivery of its services has continuously grown. In this system, the technology facilitates the delivery of the "human touch." All medical specialties depend, to some extent, on technology for achieving their goals. Some specialties more than others use medical technology, be it in the area of preventive medicine, diagnosis, therapeutic care, rehabilitation, administration, or health-related education and training. Medical technology enables practitioners to collaboratively intervene together with other caregivers to treat patients in a cost-effective and efficient manner. Technology also enables integration and systems management in a way that contributes to improvements in the level of health indicators. Hospital and clinical administrators are faced with the expectation for return on investment that meets accounting guidelines and financial pressures. Society's expectations for quality care and for the containment of the cost of care, as expressed in relationship to the gross national product, brought the need for even better integration and control into the public debate arena. In 1983, the U.S. government attempted to contain runaway healthcare costs through Federal regulation. These regulations established a new method of reimbursement, called the prospective payment system, that encouraged hospitals to manage their resources more effectively. Reimbursement methodology con


This paper is the sequel to the authors' article «Macroeconomic Modelling of Interrelations of Real and Monetary Sectors of Russian Economy (Part 1)» devoted to the construction and analysis of empirical macroeconomic model of Russia during the postcrisis period. In the first part we analyze the vector error correction model that describes the most important relations in the real sector of economy. Besides, a particular attention is paid to the dependence on the parameters reflecting a con juncture of the world markets, and also to the revealing of internal factors of economicgrowth. In the second part of this article we focus on the construction of the model of monetary sector. We analyze mechanisms of monetary and currency policies, the direction and efficiency of their influences on the basic macroeconomic parameters, such as GDP and inflation. It is also checked the correspondence of stabilization policy to the Government and Central Bank purposes.


This document provides supplementary information to "Enhancing photon correlations through plasmonic strong coupling," https://doi.org/10.1364/OPTICA.4.001363. It gives details on different aspects of the theory presented in the main text. In Section 1, the effective Hamiltonian approach in the low pumping (perturbative) regime is tested against full Liouvillian calculations. Section 2 analyzes the impact that spatial inhomogeneities in the plasmon (SP) near-field have on far-field intensity and correlations. Spectral inhomogeneous broadening in the quantum emitter (QE) ensemble is investigated in Section 3. The effect of SP losses and QE non-radiative decay on the second-order correlation function of plasmon-exciton-polariton (PEP) systems is studied in Section 4. Finally, Section 5 explores the sensitivity of photon correlations against dipole-dipole interactions within the emitter ensemble. All the calculations presented correspond to hybrid systems involving five QEs ( N = 5).


Tayma was one of the most important palm oases of Arabia, at which camel caravans rested and traded their goods. Archaeological excavations in the ancient settlement and new finds demonstrate that the oasis developed at a unique junction of ancient cultures


We have performed a photon-echo experiment on the 555.6-nm intercombination line of atomic Yb vapor which demonstrates that an intense laser field acts to inhibit the dephasing resulting from velocity-changing collisions. This finding implies that the optical Bloch equations, which assume that relaxation is independent of the strength of the driving field, cannot correctly describe the behavior of gas-phase samples in all regimes.


TCM syndrome related research has been being always the hot research,however,there are still lots of key issues that have not been resolved despite some achievements attracting people,s attentions by many scholars through decades of unremitting efforts.The thesis tries to analyze shortcomings and confusions facing research of TCM syndrome from the current situation,and give some relevant countermeasures and advices by which some new ideas and new methods will be given possibly.


One of the consequences of the westem church's two centuries of fumbling with the implications of the historical-eriticalmethod is a loss of any sense of the connection between the classical doctrines of the church and the text of Scripture. It is assumed that a truly scholarly interpretation of the scriptural texts methodologically excludes any referenee to Christian doctrine as a hermeneutical touchstone, and as a matter of historieal fact, though not of logical necessity, the historieal-critical enterprise has often been understood as the liberation of rational intelligence and religious experience from the dead hand of dogma. The doctrines, in such a context, come to seem a superstructure overlaid on the texts by theological speculation, at best a time-conditioned expression of spiritual experience somehow distantly responsive to the scriptural witness, at worst the token of the "hellenized" church's cultural allenation from that witness. By contrast, one has only to look at the sermons, commentaries, and treatises of the Fathers, Aquinas, or Luther to see how seriously they took, for example, the trinitarian and christological doctrines as analyses of the logic of the seriptural discourse, formal descriptions of the apprehension of God in the texts, which then serve as guides to a faithful and attentive reading of the texts. Where this conviction is no


We define maximum-distance-separable convolutional codes as systematic codes with (feedback) minimum distance exceeding the number of check digits in a constraint length. The maximum length of such codes is determined for certain small fields when the rate is \frac{1}{2} .


Since the introduction of direct‐acting antivirals (DAAs) several studies have reported high efficacy and safety in Hepatitis C infected patients, even in those earlier considered difficult‐to‐treat. We aimed to assess the efficacy and safety of DAA therapy in elderly patients.


This paper is devoted to the problem of the militarization of culture in modern Russia. The two key scientific fields are public history and the politics of memory. Firstly, based on the official documents and statements of authorities, the paper will characterize the relations between the state and Russian cinema as well as the role of history and historical films in the contemporary politics of memory. Secondly, after identifying the role of popular cinema in Russia, the paper will explore the characteristics of historical periods in popular films, based on the hypothesis that the Russian past is mostly represented around or inside war, while the criticism of war is becoming less and less important for popular cinema


The surface flashover of alumina ceramics insulators used in vacuum devices restricts the insulating properties of the vacuum devices.It is considered that the surface flashover in vacuum starts with the field electron emission from the joint of cathode,vacuum and dielectric.In this paper,the partial enhancement of electric field at the joint of cathode,vacuum and dielectric was analyzed;the simulation computation of the curving electrode structure was carried out through the ANSYS software;the structure that have the effect to reduce the electric field was obtained.Two types of electrode are selected to test the voltage resistance of alumina ceramics in vacuum;the results show that the hold-off voltage of alumina ceramics is increased by 45% when the curving electrode is applied than that the plate electrode is used.


As a new type of water source, reclaimed water is used to replenish the landscape water bodies of urban river courses, which can alleviate the problem of insufficient water in river courses. However, due to the large amount of reclaimed water input, the water quality of the downstream river is obviously different from that of the upstream river. In this study, with the recharge of reclaimed water, the water conductivity increased gradually from upstream to downstream of the Wenyu River river, while the pH decreased gradually. In terms of nutrient concentration, TN, NO3-N and NO2-N of river water showed an obvious upward trend from upstream to downstream.


Abstract The magnetically impelled arc butt (MIAB) welding process uses a rotating arc as its heat source and is known as an efficient method for pipe butt welding. The arc in the gap of the pipe butt joints is rotated along the circumferential weld line by the electromagnetic force resulting from the interaction of the arc current and the magnetic field in the gap. The electromagnetic force is determined by the magnetic flux density in the gap, the arc current and the arc length (i.e. gap size). In particular, the radial magnetic flux density is an important factor in arc rotation and weld quality. This paper proposes a two-dimensional finite element model for the analysis of magnetic flux density distributions in the MIAB welding process. The magnetic flux density is mainly dependent on the gap size between two pipes, the position of the exciting coil that generates the magnetic field, the exciting current in the coil, and the relative permeability of the pipes. Thus, the relations between the magnetic flux density and the above main factors were investigated through experiments and analyses. Experiments were performed on the steel pipes (outer diameter 48.1mm and thickness 2.0mm). From the analyses and experiments, it was revealed that the magnetic flux density in the gap between the pipes increases when there is an increasing exciting current and relative permeability, and a decreasing distance from the gap centre to the coil and gap size. It is considered that the numerical analysis model proposed in this study can be used as a useful means when designing an electromagnetic system for the MIAB welding machine.


Background

Identifying the most influential spreaders in HIV transmission networks is crucial to develop effective prevention strategies. The purpose of this study is to identify the key nodes of the molecular transmission network among MSM, which has significant insight into developing effective HIV prevention strategies.
Methods

We analyzed HIV-1 pol sequences provided through the Center for Disease Control and Prevention, Guangzhou, China. Sequences were obtained from newly-HIV diagnosed MSM during 2015–2017. We calculated pairwise genetic distance, identified linked pairs of sequences (those with distance ≤ 1.5%), and examined key nodes of these potential transmission partners.
Results

Of 184 HIV recently diagnosed men who have sex with men (MSM), 40.76% were linked to other MSM. Social network analysis demonstrated that there were 9 key nodes were detected. From the results of multivariate logistic regression model, young MSM born in the 1990s and 1980s was 0.06 and 0.12 times as likely to be a key node as was the older MSM born in the 1970s and before.
Conclusions

 There were a lot of subgroups connected by sharing comembers in HIV molecular transmission network among MSM in Guangzhou. Some HIV-infected MSM called as key nodes mediated the transmission of HIV among different subpopulations. Young MSM were less likely to promote HIV transmission than older MSM.


The increasing tension between the different local direct measurements of the Hubble expansion rate and that inferred from the Cosmic Microwave Background observation by $\Lambda$-Cold-Dark-Matter model could be a smoking gun of new physics, if not caused by either observational systematics or local bias. We complete previous investigation on the local bias from a local void by globally fitting the Pantheon sample over all parameters in the radial profile function of a local void described by an inhomogeneous but isotropic Lema\^{i}tre-Tolman-Bondi metric with a cosmological constant. Our conclusion strengths the previous studies that the current tension on Hubble constant cannot be saved by a local void alone.


As Hemingway put it, "A writer's problem does not change. He himself changes and the world he lives in changes but his problem remains the same. It is always how to write truly and, having found what is true, to project it in such a way that it becomes a part of the experience of the person who reads it." Against this standard, those who write on Mormon topics fare quite well. Today, for the most part, Mormons and Mormonism are looked upon with a professionalism and objectivity that only a few years ago would have been considered unthinkable. Equally amazing is the number of quality pieces. Although much of the writing comprising "Among the Mormons" is undistinguished, the periodical selections are in general both well written and interesting (as the accompanying selections illustrate). If Mormon literature is to continue the marked improvement it has experienced over the past two decades, much more of the same will be needed; authors represented here must be encouraged. These writings warrant special attention, as do the authors. Articles not appearing here but of equal quality are 1977-78 Ensign articles on the Book of Mormon characters and on saints in different parts of the country.


Abstract This paper outlines the general process of troubleshooting and rectifying unexpected structural mechanics problems in industrial plant and infrastructure. Typically the process includes the combination and correlation of site measurements (strain, vibration) and computational simulations (finite element analysis, computational fluid dynamics) to identify root cause sources and guide redesign and rectification means. Details of typical site installations are outlined, including mining machinery, gas pipelines, railway lines, manufacturing plant and ships. Four case studies are included, ranging from resin manufacturing tubular agitators suffering vortex induced resonance, ore grinding mills needing better access manhole design, mine dump trucks, and ship shafting issues.


This research tried to study hydraulic performance of morning glory spillway by numerical modeling. The Flow 3D software was used for numerical modeling and the morning glory spillway was studied based on USBR standard. Using a numerical model, the hydraulic parameters of the flow such as coefficient of discharge, water level profile and pressure distribution were determined and compared with the data obtained from USACE and USBR models. Although comparing the parameters shows a good and show agreement between the results, however, using the numerical model in real samples has limitations such as the number and size of the network, computational time and accurate modeling of the weather, which require more research in this area. DOI: http://dx.doi.org/10.3126/ijls.v9i4.12671


Imagination has some important functions in conducting scientific cognition.Of the functions,the basic ones are as follows:it makes scientific cognition transcendental and creative and also it is the internal factor that leads to the reach of scientific truth.The formation and development of imagination are generally based on substantial objects and practice as well.Imagination is an ordinary thinking mode in human recognition.Human beings will develop the ability greatly with the un-covering of the secrets of the imagination functions in scientific cognition.


There are currently no thruster modeling codes that can be integrated with power system codes for full propulsion system modeling. Most existing thruster models were written from a 'stand alone' viewpoint, assuming the user is performing analyses on thruster performance alone. The goal of the present modeling effort is to develop thruster codes that model performance and scaling as a function of mission and system inputs, rather than in terms of more elemental physical parameters. System level parameters of interest are as follows: performance, such as specific impulse and efficency; terminal characteristics, such as voltage or current; and mass. Specific impulse and efficiency couple with mission analyses, while terminal characteristics allow integration with power systems. Additional information on lifetime and operation may be required for detailed designs.


abstract Violence against women is extremely prevalent in South Africa, with one of the highest levels of reported rape world-wide. This article highlights the voices of young women who experienced fear and violation in South Africa, more specifically their acts of resistance in the face of adversity and their process of resilience. The article is based on research which explored how women's lives and identities are transformed by living in violent spaces, such as South Africa. The research adopted a biographical-interpretive methodology and drew on psychosocial and narrative theory, as well as literature surrounding the social-ecological systems approach of resilience and research on resistance. Free-association narrative interviews were conducted with 27 female university students in Cape Town and narrative theory was used to analyse the interview texts. The article draws on the interviews of three of these women. Findings reveal how these women are not just 'victims of patriarchy' but are agentic beings capable of acts of resistance and demonstrating resilience in the face of violence and adversity. Situating the women's narrative responses to the violence within their social ecologies reveals firstly, the importance of women's agentic selves, and secondly, the critical limits on an over-reliance on women's individual strengths and resilience. It is argued that it is neither just nor sustainable to expect women to carry the individual responsibility for sexual violence alone. Instead, the burden rests on society to remedy the high level of incidence of sexual violence with which women live.


In the system of privilege management infrastructure (PMI), the maintenance of attribute certificate is very important. Especially in the application environment where users' roles are relatively fixed, unreasonable certificate revocation management will bring enormous operations or burden onto network transmission. And the release of certificate revocation list is founded by attribute authority (AA) and handed to a public directory to release. Because public directory cannot be ensured safe or credible, it cannot be supposed that the institution is credible in the release of revocation list. So the sign of AA is needed to ensure the authenticity of certificate revocation list. This paper puts forward a maintenance scheme of certificate revocation list, which solves the above problems. The validity, security and capability of this scheme are analyzed.


This study aims to compared effect of balance between general walking exercise and power walking exercise. Twenty subjects were classified into two groups, general walking exercise(n=10) and power walking exercise(n=10). As a result, two group showed difference within the group and there is significant difference between two groups. 1) In compared static balance of sway area at pre-post test to exercise group, general walking exercise group did not change significantly. however, power walking exercise group did change significantly. and At sway distance, two group showed significant changes. 2) In compared Static balance between the groups sway area and sway path at pre-post test, two group showed significant changes. 3) In compared dynamic balance of center distance at pre-post test to exercise group, general walking exercise group was no significant difference in all directions. power walking exercise group was significant difference in all directions. 4) In compared dynamic balance between the groups sway area and sway path at pre-post test, there was no significant difference in leftward, rightward, forward directions and was significant difference in backward, overall direction. Therefore, power walking exercise can be recommended promote balance.


T H E population of Northern Ireland is probably unique in that i t is composed of two groups of people each of which can be characterized as a "minority". Conventional wisdom has it that at present there is a dominant Protestant majority wishing to maintain political links with Great Britain, and a Catholic minority desirous of closer links with, i f not absorption by, the Irish Republic. The seeming paradox of two minorities is explained, on the one hand, by the existence of the current Catholic minority; and, on the other, by a Protestant group, in the major ity at present, fearing that in time it wi l l become a minority. As the recent Commission on Disturbances in Northern Ireland said ". . . among Protestants there are deep-rooted suspicions and fears of political and economic domination by a future Catholic majority in the population". This fear is partly caused by the knowledge that the average size of Catholic families is significantly larger than average non-Catholic families. Out of this situation has sprung rumour and counter-rumour concerning the precise current population balance between the two communities. The current proportions of Protestants and Catholics in the population of Northern Ireland and possible changes in them through time are thus inevitably of considerable political significance. It is not only the actual proportions that are important, but also what people believe them to be. In addition, it could be argued that political attitudes (and actions) are significantly affected by what people think wil l happen in the future to the distribution by religious adherence of the Northern Ireland population. The aims of this paper are fivefold, First, to set out the changes that have taken place in the proportion of Catholics and non-Catholics during the last 100 years.


In our legal system, Copyright Law confers protection to authentic photographies and due to this feature, they are considered photographic works. Nevertheless, authorities have not given enough information of what a photography requires to be considered authentic. On account of this, the shortcomings of our related rules are evaluated to determine which foreign legislation gives a better referent, and to analyze the different views given to the authenticity concept by doctrine and case law. All of this with the purpose of determining specific criteria to qualify a photography as authentic and protected by Copyright Law, and proposing changes in our current legislationon the matter.


To investigate the possible role of tryptophan metabolism in immune regulation of primary Sjögren's syndrome (pSS) the serum concentrations of tryptophan and its metabolite kynurenine were measured by reverse‐phase high‐performance liquid chromatography (HPLC) in 103 patients with pSS, 56 patients with sicca symptoms and 309 healthy blood donors. The kynurenine per tryptophan ratio (kyn/trp), which reflects the activity of the indoleamine‐pyrrole 2,3‐dioxygenase (IDO) enzyme involved in tryptophan catabolism, was calculated. Both female and male patients with pSS had significantly higher serum kynurenine concentrations and kyn/trp than subjects with sicca symptoms or healthy blood donors. The median (quartile range) concentration of kynurenine in female patients with pSS was 2·41 µmol/l (1·86–3·26) compared with 1·85 µmol/l (1·58–2·38, P < 0·0001) in subjects with sicca symptoms and 1·96 µmol/l (1·65–2·27, P < 0·0001) in healthy blood donors. Their kyn/trp × 1000 was 34·0 (25·1–44·3) compared with 25·3 (21·1–31·5, P < 0·0001) in subjects with sicca symptoms and 24·3 (21·0–28·9, P < 0·0001) in healthy blood donors. Female pSS patients with high IDO activity (kyn/trp × 1000 ≥ 34·0) had significantly higher ESR, serum C‐reactive protein, serum IgA and serum beta‐2 microglobulin concentrations as well as higher serum creatinine levels, and they had positive antinuclear antibodies more frequently and presented with more American‐European consensus group criteria than those with low IDO activity (kyn/trp × 1000 < 34·0). These data suggest that mechanisms dependent on tryptophan catabolism regulate immune responses in pSS. Tryptophan degradation is enhanced in patients with pSS, and high IDO activity is associated with severity of pSS.


Ficus exasperate is a small tree well known on account of its very rough leaves being used as paper widely spread in all eco-regions of Nigeria. The plant has been ethno botanically reported to have diverse medicinal uses. It is used in herbal medicine to treat cough, hemorrhoid and lowering high blood pressure. Ethanol, ethyl acetate and hexane extracts of this plant were obtained by maceration and tested for antimicrobial activity using agar diffusion and micro broth method dilution techniques. However, Phytochemicals screening of the hexane extract revealed the presence of alkaloids, saponins, flavonoids, cardiac glycoside, steroid, legal test, alkaline reagent and phenol in Sandpaper with no traces of tannins and reducing sugar. The ethyl acetate extract revealed that all test was presence except from the Alkaline reagent and reducing sugar, while the ethanol extract revealed the presence of saponins, tannins, steroid, legal test, cardiac glycoside and phenols without traces of alkaloids, alkaline reagent and flavonoids. The Sandpaper exhibited a wide range of activity on Ethanol, N-haxane and Ethyl acetate extracts at concentration of 5.075, 1.665 and 3.09g respectively. The above results show that F. exasperata leaf contained bioactive substances with the highest inhibitory activities against some human pathogenic organisms. This study justifies the ethno pharmacological uses of these medicinal plants for treatment of microbial infections.


Nowadays the upsurge in the prevalence of chronic diseases represents an increasing burden on individuals and society. Chronic diseases can require repeated and frequent hospital treatment to control vital parameters of interest. The use of automatic instruments for a real-time monitoring of biological parameters constitutes a valid instrument to improve the patient's quality of life. The integration of mobile communications with wearable devices has facilitated the shift of healthcare assistance from clinic-centric to patient-centric monitoring. In this paper, a real-time monitoring system is proposed. The system is conceptualized to provide an instrument for patients, by means of which they can easily monitor, analyse and save their own vital signs using wearable sensors and an Android device such as a smartphone or tablet, offering an efficient solution in terms of a decrease in time, human error and cost.


In this paper, the investigation on using the ZTE /modified SPIHT wavelet based compression algorithm for the image retrieval system is presented. As ZTE/modified SPIHT algorithm codes an image into multi-layer bitstreams, the base layer and enhancement layer bitstreams, it provides superior benefits to the retrieval system compared to other compression methods. Since the base layer bitstream is analogous to a thumbnail image, it eliminates the redundancy of data. Moreover, the enhancement layer bitstream also allows fast transmission that enhances the performance of retrieval systems.


Abstract India has a great variety of natural stones that have been extensively used as dimension, ornamental and sculptural stone for numerous temples and monuments over many centuries. These temples and monuments, now heritage sites, have a major role in showcasing India's natural stone resources that occur in diverse geological formations of different geological systems across the Indian subcontinent. The formations contain a variety of stone, with colours and textures produced by varied geological processes thus providing a storehouse of diverse stone resources. This paper outlines four potential Global Heritage Stone Provinces where natural stones have been used in heritage monuments: the North and Northwestern Province, the Central and Western Peninsular Province, the Southern Peninsular Province and the Eastern and Northeastern Province. The geotechnical and aesthetic characteristics of the stones, and their response to weathering are discussed.


Single crystals of the mixed rare-earth orthoferrite Dy1-xHoxFeO3 (x=0.25, 0.5, and 0.75) have been studied by Mossbauer spectroscopy in the 1.3-298 K temperature range. Several temperature-induced Fe3+ spin reorientation transitions have been observed. On cooling, a locally discontinuous reorientation from the a to the b orthorhombic axis took place near 40 K followed by a continuous reorientation from the b to the c axis. The onset temperature of the latter transition depends linearly on Ho concentration x. An x-T phase diagram of Dy1-xHoxFeO3 is proposed which extrapolates well to the results of previous studies of pure HoFeO3 and pure DyFeO3. The continuous Fe3+ spin reorientation in the bc plane showed the hyperfine interactions of the 57Fe nuclei to split into two branches. This branching is associated with different Fe unit cell positions. The temperature variation of the difference in magnetic hyperfine fields agrees well with a previous calculation of a similar effect in NMR. We also observed a new, very sharp Fe3+ spin reorientation from the c to the b orthorhombic axis upon cooling a Dy1-xHoxFeO3 single-crystal absorber between 3 K and 2.3 R. We suggest that this transition is driven by ordering of the rare-earth spins and a microscopic mechanism is proposed.


Anti–programmed cell death 1 (PD-1) antibodies have demonstrated anticancer activities and survival benefit but, because of their mechanism of action, have been associated with autoimmune and alloimmune adverse events.1 We report the case of a kidney transplant patient who presented autoimmune hemol