Sex hormones influence the development and natural course of psoriasis. Here, we examined the effects of female sex hormones, particularly oestrogen, on psoriasis‐like dermatitis induced using topical imiquimod in mice that underwent either sham operation (Sham) or ovariectomy (OVX), with (hormone replacement treatment: HRT) or without 17β‐oestradiol targeting the maximum physiological levels. The number of neutrophils in the skin was higher in the order of OVX‐, Sham‐, and HRT‐treated mice. However, no significant difference was detected in the clinical scores among the three groups due to severe erythema and scale in a few mice out of HRT‐treated mice in a set of experiments. OVX‐ and HRT‐treated mice showed increased mRNA levels of interleukin (IL)‐22 and IL‐23 compared with Sham‐treated mice; increased IL‐10 mRNA levels were found in HRT‐treated mice, possibly due to an increased proportion of forkhead box P3 (Foxp3)‐ and IL‐10 positive large cells (possibly macrophages). In addition, HRT‐treated mice had a more compact stratum corneum with higher expression of loricrin and involucrin than OVX‐ and Sham‐treated mice. This study suggests that oestrogen has a dual potential in the pathogenesis of psoriasis: suppression of inflammation by enhancing IL‐10 production and enhancement of inflammation by induction of IL‐22 and IL‐23 expression.


GaAs samples have been irradiated with fast neutrons up to doses of 1*1020 n0 cm-2. EPR measurements revealed the four-line spectrum attributed to AsGa defects and the singlet spectrum previously ascribed to gallium vacancies. The dose dependences of these spectra imply that the paramagnetic 'singlet' defects are located in the core regions of disordered material whereas the AsGa centres must be located both in the cores and the surrounding shells of less-heavily damaged material. Isochronal anneals up to 550 degrees C of undoped or n-type samples showed that the AsGa centres were still present after the singlet spectrum had annealed at 500 degrees C. The spin-lattice relaxation time for the former defect increased during this latter stage. Some comments are made about the identity of the defects giving the singlet spectrum.


Ammonium plutonium(IV) fluorides, PuF4.7/6NH4F and PuF4.2NH4F, were prepared by the addition of an acidic solution containing Pu(IV) to a mixed solution of NH4F and HF. Anhydrous PuF3 was obtained by thermal decomposition of the ammonium plutonium(IV) fluorides under reduced pressure or else in an inert gas flow. The anhydrous fluoride was then reduced with Li vapor to Pu metal. Cerium metal was prepared by the same method.


Response of Terminalia chebula Retz. To application with three different Biofertilizers like Azospirillum , phospobacteria and vesicular arbuscular mycorrhizal (VAM) and four different Biofertilizers combinations like Azospirillum with Phospobacteria, Azospirillum with VAM Phospobacteria with VAM and Azospirillum with Phospobacteria and VAM was studied under nursery condition. The plants were assessed for increment in height, stem girth, collar diameter and number of leaves at 30, and 60 days of treatment. The treatment with combination of Azospirillum 5g + Phospobacteria 5g to polythene bags (22 × 15 cm) containing soil, sand and FYM (2:1:1) showed higher growth in height, stem girth and root collar diameter. Seedling treated with VAM also had greater shoot and leaf biomass. The use of Biofertilizers such as Azospirillum , Phospobacteria and Vesicular Arbuscular Mycorrhizal fungi (VAM) on Terminalia chebula to solve the problem of slow growth of seedlings is discussed.


On the basis of an investigation , the natural grassland rat destruction in Tacheng region is analyzed. This paper discusses the distribution and destruction of the rat in the area and effective control ways.


The present invention relates to wound dressings of the water vapor-permeable backing layer, and a tacky, substantially solvent-insoluble, solvent dispersible, water vapor permeability, causing less skin damage, including acrylic elastomeric, pressure sensitive adhesive micro-spheres made of continuous particle-containing adhesive layer .


When I started corneal grafting in 1950, I began to wonder whether there was any connexion between the clarity of a graft and the recovery of sensation in it. The literature then was meagre and conflicting. For instance, Franceschetti & Babel (1947) concluded that reinnervation and recovery of sensation were essential if a graft were to remain clear, whereas Escapini (1948) and Moss (1949) found that the recovery of sensation was independent of the clarity of the graft. There was no mention of this aspect in the notable report by Paufique et al. (1948).


This article represents a first step towards understanding the well-posedness for the dispersive Hunter-Saxton equation. This problem arises in the study of nematic liquid crystals, and although the equation has formal similarities with the KdV equation, the lack of $L^2$ control gives it a quasilinear character, with only continuous dependence on initial data.
Here, we prove the local and global well-posedness of the Cauchy problem using a normal form approach to construct modified energies, and frequency envelopes in order to prove the continuous dependence with respect to the initial data.


groups haYe been prepared,and their electrochromlCand electroluminescent properties basedontheD-Ainteractions wereinvestlgated 【1,21. Inthispaperwereportthepreparationofnovel carbazole-COntaimng coqugated polymers by Sonogashira coupling reaction・Forthe DrA POlymer uslng benzothiadiazole moiety as an acceptor group,the chargeJtranSfer(CT)band clearlyappearedinthevisibleregion・TheoptlCal PrOPerties were compared with those of the PreViously reported catbazole-benzothiadiazole (M)altemating copolymers with diffbrent SPaCerS・


This volume offers a novel, trans-regional vision of Viking Age (9th-11th century) cultural and political contacts between Scandinavia and the eastern coasts of the Baltic Sea, using predominantly archaeological evidence, combined with historical sources, topography and logistical considerations.


Unsteady sheet cavitation on a three-dimensional twisted hydrofoil was studied using a Reynolds-averaged Navier–Stokes simulation technique based on a cell-centered finite volume method. As a verification test of the computational method, the leading edge and mid-chord cavitating flows over a two-dimensional modified NACA66 foil section were simulated for various cavitation numbers and validated against existing experimental data. The cavitation model parameters and numerical schemes were determined by a comparison with the measured pressure distribution. Non-cavitating and cavitating flows around a three-dimensional twisted hydrofoil were simulated with the selected computational method. The computed pressure on the foil and the cavity shedding patterns were validated by comparing these results with existing experimental data. The cavity shedding dynamics due to a re-entrant jet and a side entrant jet were investigated in terms of the cavity shedding cycles. The computed lift force and Strouhal number were compared against existing experimental data.


Searching for images of people is an essential task for image and video search engines. However, current search engines have limited capabilities for this task since they rely on text associated with images and video, and such text is likely to return many irrelevant results. We propose a method for retrieving relevant faces of one person by learning the visual consistency among results retrieved from text correlation-based search engines. The method consists of two steps. In the first step, each candidate face obtained from a text-based search engine is ranked with a score that measures the distribution of visual similarities among the faces. Faces that are possibly very relevant or irrelevant are ranked at the top or bottom of the list, respectively. The second step improves this ranking by treating this problem as a classification problem in which input faces are classified as psilaperson-Xpsila or psilanon-person-Xpsila; and the faces are re-ranked according to their relevant score inferred from the classifierpsilas probability output. To train this classifier, we use a bagging-based framework to combine results from multiple weak classifiers trained using different subsets. These training subsets are extracted and labeled automatically from the rank list produced from the classifier trained from the previous step. In this way, the accuracy of the ranked list increases after a number of iterations. Experimental results on various face sets retrieved from captions of news photos show that the retrieval performance improved after each iteration, with the final performance being higher than those of the existing algorithms.


Considering the security of embedded equipment,this paper studies the necessity and feasibility of developing embedded Linux system based on Loogson 2E.The configuration of bootloader,customization of kernel and establishment of root file system are introduced and the way of exploring device-driver procedure is given.


Introduction Donor cell leukemia (DCL) is a rare complication of allogeneic stem cell transplantation (allo-SCT). The leukemic transformation of otherwise healthy donor stem cells provides a useful in vivo model to study the mechanisms involved in leukemogenesis. The objective of the present study is to study the dynamics of emergence of mutations that precede the development of DCL. Material and methods We report the case of a female patient diagnosed of acute lymphoblastic leukemia with t(1;19), who developed normal karyotype acute myeloid leukemia (AML) of donor origin 16 months after unrelated cord blood transplantation (UCBT). Whole exome sequencing(SureSelect-XT Human exon capture 50Mb Agilent Technologies) was performed by next generation sequencing (Hiseq 2000 Illumina) on bone marrow samples post allo-SCT, obtained in the days +98, +189, +350, +486 (DCL diagnosis) and + 569 (DCL relapse) as well as on the UCB unit used in SCT. The exome of bone marrow samples post allo-SCT were aligned to the human reference genome (NCBI build 37/hg19), non-synonymous variants in the coding regions of genes related to leukemia were selected and matched to the UCB exome to identify the acquired variants. Variants meeting such criteria were evaluated with three softwares (SIFT, Polyphen and Mutation Taster) to predict their functional effects. The UCB exome was aligned to the human reference genome (NCBI build 37/hg19). Results In silico variants analysis revealed progressive emergence of multiple mutations related to the development of leukemia in bone marrow samples post allo-SCT (Figure 1). Interestingly three of the mutated genes (PTPN11, NRAS, MAP2K1) are part of the same cellular pathway (RAS-MAPK). In addition, mutations in leukemic subclones that disappear after chemotherapy were indentified, as well as the acquisition of new mutations in resistant subclones (Figure 2). Finally a mutation in SH2B3 gene, a gene that encodes for a regulatory protein of the JAK-STAT pathway, which links strongly to JAK2 inhibiting the activation of the pathway, was detected in the CBU. Conclusions The present study reveals the acquisition of additional somatic mutations in donor cells during leukemogenesis, including mutations not previously described in AML initiation (POU2F2, CA9, POU4F1, FMN2, TLR9, ELF5). Although the cause of DCL onset seems to be multifactorial, the infusion of a CBU with pre-leukemic potential due to mutation in SH2B3 in a context of residual toxicity in recipient as a result of pre-transplant chemotherapy, a post-transplant environment characterized by a decreased immune surveillance may well have played role in the case here reported. The study of a greater number of DCL cases by next generation sequencing could help to understand the process of leukemogenesis. Disclosures No relevant conflicts of interest to declare.


The aircraft descent profile has many factors, such as selected airspeed, flight weight, wind, initial altitude, and outside temperature even if fixed idle thrust was assumed. This article tries to prove a rule of thumb that " Even if the wind changes at lower altitude during descent, the flight path will converge at a lower altitude ". This may be useful information for flight operation, if it is correct. In addition idle thrust descents are a useful method for fuel economy operation. This paper tries to support this rule of thumb by numerical simulations of flight paths with different wind conditions.


Recent experiments on fermions in synthetic gauge fields result in systems with a spin-orbit coupling along one spatial axis, a detuning field, and a Zeeman field. We show theoretically that the presence of all three results in interesting and unusual phenomena in such systems in the presence of a contact singlet attraction between the fermions (described by a scattering length). For two particles, bound states appear over certain range of the centre of mass momenta when a critical positive scattering length is attained, with the deepest bound state appearing at a nonzero centre of mass momentum. For the centre of mass momenta without a bound state, the gauge field induces a resonance like feature in the scattering continuum resulting in a large scattering phase shift. For many particles, we demonstrate that the system, in a parameter range, shows flow enhanced pairing, i.e., a more robust superfluid at finite centre of mass momentum. Yet another regime of parameters offers the opportunity to study strongly interacting normal states of spin-orbit coupled fermionic systems utilizing the resonance like feature induced by the synthetic gauge field.


This chapter introduces the reader to the two case study villages Neukirch and Ebersbach, explains the methodology of the study, and outlines the structure of the book. It also sets out the central argument that there were parallel histories of responses to social change among villagers in the divided Germany. The chapter then outlines the three major ways in which the book contributes to scholarship on postwar Germany: Firstly, by highlighting similarities between East and West, it complicates persisting Cold War divisions in the historical literature. Secondly, it emphasizes the complex ways in which East and West Germans engaged with large-scale changes through peculiarly local meanings. Thirdly, by focusing on two case study localities which question conventional divides between the urban and the rural, it challenges understandings of the rural as the traditional 'other' in modern society.


Regulation of solar and thermal radiation of building envelope shows huge energy‐saving potentials. Existing reviews mainly focus on the materials with fixed solar and thermal optical properties. Although there are reviews reporting the materials with modulated optical properties (e.g., radiative cooling materials with modulating thermal emissivity while maintaining high solar reflectance), they merely focus on either solar or thermal radiation modulation, which can provide limited or even negative building energy savings and thus may mislead the researchers to design low energy‐efficient materials in practice. To help gain a holistic understanding of the state‐of‐the‐art solar and thermal radiation‐modulation materials (STRMMs) and guide researchers to develop more effective STRMMs for maximum building energy savings, here the STRMMs are reviewed in three categories, solar radiation modulation, thermal radiation modulation, and synergetic solar and thermal radiation modulation. In the former two categories, only single solar or thermal optical property is modulated while in the third category both solar and thermal optical properties are modulated. For STRMMs in each category, their working principles, representative examples, potential applications and future perspectives are compared and elaborated.


Brexit, in whatever form, could have a major impact on the recognition of cross-border insolvency proceedings in the UK. It will be some time before the actual impact can be fully determined, but the mere threat that it could deter creditors from using English insolvency and restructuring procedures should encourage the UK to consider its options.


Ricardo Gobato1*, Alireza Heidari2 and Abhijit Mitra3 1Laboratory of Biophysics and Molecular Modeling Genesis, State Secretariat for Education of Paraná, Brazil 2Faculty of Chemistry, California South University, USA 3Department of Marine Science, University of Calcutta, India Received: July 23, 2018; Published: August 07, 2018 *Corresponding author: Ricardo Gobato, Laboratory of Biophysics and Molecular Modeling Genesis, State Secretariat for Education of Paraná, Bela Vista do Paraíso, Paraná, Brazil         UPINE PUBLISHERS Open Access L Archives of Organic and Inorganic Chemical Sciences


This paper examines the application of neural network techniques to the control of an open loop unstable ball-beam system. Computer simulation and implementation using both conventional pole-placement and neural network methods of control have been undertaken. Two-layer networks have been used in both the simulation and the experimental implementation. The error backpropagation, the temporal-difference, and the reinforcement learning algorithms have been used in the neural network controllers. The results from simulation and also from real time control experiments show that the time required to balance the ball-beam system has been significantly reduced by using neural networks.


Due to various architectural constraints and multi‐functional requirements for modern buildings, combined structural forms, which typically include shear wall systems in higher zones and moment‐resisting frames together with core walls in lower zones, are commonly used for these buildings. Transfer structures are often introduced to transfer the loads from higher to lower zones. Previous experimental and numerical studies have demonstrated that the exterior walls above the transfer structure are particularly vulnerable structural members under seismic loading. In this paper, a qualitative model is presented for simulating the shear concentration effect in exterior walls with consideration of the local deformations of transfer structures. A parametric study was carried out to validate the model and to quantify various factors which may influence the shear concentration effect. A shear concentration factor, which can measure the intensity of shear stress concentration in the exterior walls, is defined. Based on the numerical study, design principles are recommended to seismic engineers for minimizing the adverse shear concentration effect on exterior walls under seismic loads. Copyright © 2008 John Wiley & Sons, Ltd.


The purpose of the study was to analysis about influence of social capital on the satisfaction of neighborhood. Attachment and adoptability are having a positive effect and interaction is having an negative effect on the satisfaction of the neighborhood. Attachment, interaction, and acceptance were positively influenced by satisfaction of neighborhood.


CONTENTS: SCIENTIFIC RESEARCH RESULTING IN A PROPOSAL FOR AN INTERNATIONAL STANDARD ON TESTING ROCKS UNDER UNIAXIAL COMPRESSION AND SHEAR WITH COMPRESSION EFFECT OF ACCURACY IN ROCK-SPECIMEN PREPARATION ON THE RESULTS OBTAINED EFFECT OF DIMENSIONS ON TENSILE AND SHEARING STRENGTH ANALYSIS OF AN INTERNATIONAL SURVEY AIMED AT THE DEVELOPMENT OF EQUIPMENT FOR TESTING ROCKS UNDER TRIAXIAL COMPRESSION A NEW COMBINED METHOD OF ROCK TESTING FOR TENSILE, COMPRESSION AND BENDING STRENGTH, IN WHICH THE SAME SPECIMENS ARE USED REPEATEDLY TEST RESULTS OBTAINED BY THE ABOVE METHOD FOR A NUMBER OF BEDROCKS IN COAL AND ORE DEPOSITS CHANGES IN ROCK PROPERTIES OBSERVED IN THE ZONE OF CONTACT WITH TOOLS, ON WHICH A METHOD OF ASSESSING BRITTLENESS AND PLASTICITY FROM CHANGES IN HARDNESS (UNDER INDENTATION OF IMPACT) IS BASED A PROPOSAL FOR IMPROVING HARDNESS TESTING OF ROCKS CONTAINING SEVERAL MINERALS, BY DETERMINING THE CONTENT AND HARDNESS OF EACH INDIVIDIDUAL MINERAL EFFECT OF PHYSICAL AND MECHANICAL ROCK PROPERTIES ON DRILLABILITY, AS ANALYZED IN MANY YEARS OF RESEARCH. /LCPC/RRL/


Fifty-two patients who had had a single previous caesarean section were submitted to a trial of scar. labour was monitored by internal tocography and direct fetal heart rate monitoring. Oxytocin infusion was employed wnen uterine work proved to be inadequate. The ox.ytocin-augmented and unstimulated groups were compared. Oxytocin augmentation improved uterine worl<and.did not result in significant fetal or maternal morbidity or mortality. Internal tocogrcaphy was found to be of value, but fetal heart rate monitoring was essential.


Results of the study of М. V. Lomonosov's pedagogical ideas and activities in the domestic historiography are characterized, periodization of the formation process of pedagogical views of M. V. Lomonosov and periodization of his scientific-pedagogical activity are presented in the article.


Experiments were conducted to study the effects of micro-pin-fins and submicron-scale roughness on the boiling heat transfer from a silicon chip immersed in a pool of degassed and gas-dissolved FC-72. Square pin-fins with fin dimensions of 50×50×60 μm 3 (width ×thickness×height) and submicron-scale roughness (RMS roughness of 25 to 32 nm) were fabricated on the surface of square silicon chip (10×10×0.5 mm 3 ) by use of microelectronic fabrication techniques. Experiments were conducted at the liquid subcoolings of 0, 3, 25, and 45 K. Both the micro-pin-finned chip and the chip with submicron-scale roughness showed a considerable heat transfer enhancement as compared to a smooth chip in the nucleate boiling region. The chip with submicron-scale roughness showed a higher heat transfer performance than the micro-pin-finned chip in the low-heat-flux region


Abstract We present the random field based theory of relaxor ferroelectrics such as PMN, PSN and PLZT. We consider relaxors as systems of defects of different type (e.g. random site and orientation electric dipoles, lattice vacancies etc) embedded into Burns reference phase with long-range ferroelectric order; this order is being destroyed by the aforementioned defects. The equations for description of relaxors phase diagram as well as other observable properties like static or dynamic linear and nonlinear dielectric susceptibility has been derived. These equations also permit to obtain the relaxation times distribution function in relaxors. The latter function has been calculated for different parameters of relaxor ferroelectrics, corresponding to several well-known empirical relaxation laws like Cole-Cole (CC), Davidson-Cole (DC) and Kohlrausch-Williams-Watts (KWW). Fairly good agreement between theory and experiment has been achieved.


We propose an improved algorithm for finding roots of polynomials over finite fields. This makes possible significant speedup of the decoding process of Bose-Chaudhuri-Hocquenghem, Reed-Solomon, and some other error-correcting codes.


The utility model provides a cable reeling and coiling device and system. The cable reeling and coiling device and system comprise a branch wheel rotating base, a rail wheel, a gear rotating device and a ring diameter device. The branch wheel rotating base comprises a branch wheel base and a supporting shaft, and the rail wheel is connected to the supporting shaft in a sleeved mode. The gear rotating device comprises a gear base, a gear center shaft, a gear support and a power output component. The inner surface of the gear base is provided with teeth, and an output shaft of the power output component is meshed with the teeth. The ring diameter device comprises a supporting disc and a supporting circular diameter, the supporting disc is connected to the supporting shaft in a sleeved mode, and the two ends of the supporting circular diameter are connected with the supporting disc and the rail wheel respectively. The ring diameter device, the gear base and the rail wheel are connected to form a whole. The power output component drives the gear base, and the gear base drives the ring diameter device and the rail wheel to rotate. By the adoption of the cable reeling and coiling device and system, the situation that coiling is connected on inhaul cables manually is avoided, and coiling efficiency is improved; meanwhile, bumping, caused by manual misoperation, to the inhaul cables is avoided, and coiling quality is improved.


Abstract Saadatfar, Z. and Shahsavani, D. 2007. Structure of barbel in sturgeon (Acipenser percicus). J. Appl. Anim. Res., 32: 65–67. Acipenser percicus had a short pair snout barbel. It was 2–2.5 cm that is about 1.5% of its body length. Its diameter at the base was 2.5–3 mm and at its apex was 0.7–1 mm. Its epidermis was multilayered epithelium that had columnar cells, club cells and squamous cells. There were taste buds especially on the apex of barbel. The size of barbel was 50 μm in height and 25–30 μm in width. The dermis had collagen bundle similar to striated muscle. Myelinated fibers were in the core of barbel, they were for innervation of taste buds in the barbel. This fish had an elastic cartilaginous skeleton and the barbel of this fish was from flexible cartilage, with taste buds and without intrinsic muscle.


The authentication and verification of user and device identities require cost-effective solutions. Two emerging approaches, biometric authentication and devices' fingerprint, allow users and devices to prove their identity efficiently and securely. Furthermore, users are inclined to register multiple services with the same secret information. Therefore, the potential risks brought by the reuse of secret information need to be taken seriously. This paper proposes the RUDBA scheme, a novel reusable user-device biometric authentication scheme that captures the user's biometrics and the device's fingerprint. The extracted confidential is fused as authentication information for the user-device pair's identity and can provide a symmetric key for the subsequent communication. This scheme is implemented using the public biometric dataset and the intrinsic SRAM PUF data. The experimental results and analysis show that the RUDBA scheme leads to a reliable and reusable users-device authentication system.


The utility model discloses a four-joint sighted robot. A frame mechanism comprises a frame, a motor, a planetary gear reducer, a turntable, a base, and two bearing seats; the motor drives the planetary gear reducer to rotate, thereby driving the turntable, the base and the bearing seats to rotate; an upper arm mechanism component comprises a motor, a planetary gear reducer, a first-stage drive shaft, two first-stage drive arms, two first-stage driven arms, and two middle splints; the motor drives the planetary gear reducer to rotate, thereby driving the first-stage drive shaft and a parallelogram movement mechanism to move; a forearm mechanism component comprises a motor, a planetary gear reducer, a second-stage drive shaft, an arc gear synchronous belt, a driven wheel, a belt wheel shaft, two second-stage drive arms, two second-stage driven arms, and two end splints; the motor drives the planetary gear reducer and the second-stage drive shaft to rotate; the arc gear synchronous belt drives the driven wheel to rotate, thereby driving the parallelogram movement mechanism of the forearm to rotate; the four-joint sighted robot also comprises a hand component and has the advantages of simple structure, convenient use and cost reduction.


Revealed regularities of influence of anisotropy of mechanical properties on the stress state, power modes and limits of deformation in the extraction system with decreasing thickness of thick-walled axisymmetric blanks.


Objective:To explore efficacy ,side effect and mechanism of rispredone.Methods:Sixty schizophrenics were randomly divided into the three groups of rispredone,clozapine and sulpride,PANSS and TESS scales were used to measure their efficacy and side effect and then t\|test and χ 2\|test were also used to analyze them.Results:Rispredone was better than sulpride in treating positive symptoms.Conclusions:Rispredone was less on side effect.


Juvenile clams were observed on Mellita isometra Harold & Telford, 1990 (Echinoidea: Mellitidae), a lunulate sand dollar, collected off of St Catherines Island, GA, USA, in June 2008. These small clams (ranging from 0.5 to 3 mm in length; Fig. 1) had closed their valves on spines along the fringe, in the lunules and on the oral and aboral surfaces of the sand dollars. The ectosymbiotic crab Dissodactylus mellitae (Rathbun, 1900) is commonly found on the oral surface of M. isometra (Ruppert & Fox, 1988; George & Boone, 2003), but we found no previous reports of juvenile clams attached to sand dollars. We addressed several questions about this clam/crab/sand dollar association: (1) Were juvenile clams commonly present on sand dollars and where on the sand dollars were they located? (2) Was there evidence for any interaction between the juvenile clams and the crab Dissodactylus mellitae? (3) What species of clam were we observing? To answer these questions, we collected a total of 300 sand dollars at three sites on St Catherines Island: North Beach, the Ramp and South Beach (described in Prezant et al., 2002). St Catherines Island is a barrier island on the coast of Georgia and these sites are spread across about 12 km of coastline. All collecting was done at low tide in 1–2 m of water. For each sand dollar we recorded the width of the sand dollar, the number of D. mellitae crabs and the number of clams on each sand dollar. We also recorded where on the sand dollar each clam was attached (on the fringe, in a lunule, on the aboral surface or on the oral surface). All data were recorded in the field, immediately after lifting the sand dollar from the substrate. This was important as our preliminary observations revealed that the clams released their attachment if the sand dollar was placed in a container and transported any significant distance. We also collected juvenile and adult clams in 95% ethanol for microscopic examination and genetic study. We found a total of 142 clams on 300 sand dollars. Twenty-seven per cent of sand dollars had one or more clams, with a maximum of nine clams observed on one sand dollar. The clams were most common on the sand dollar fringe (86/ 142 observations, 61%). The lunules were the second most common location (40/142, 28%). Clams were rarely found on the aboral surface (14/142, 10%) and almost never on the oral surface (2/142, 1%). We found a total of 419 D. mellitae crabs on 300 sand dollars. Sixty-eight per cent of sand dollars had one or more crabs, with a maximum of seven crabs per sand dollar. These results are similar to observations from George & Boone (2003) at Tybee Island, GA, USA. We found no evidence for an association between the presence of one or more crabs and the presence of one or more clams on a sand dollar (x test, P 1⁄4 0.11). Dissodactylus mellitae were found almost exclusively on the oral surface of sand dollars. As clams were rarely observed on the oral surface, the clams and crabs may not have an opportunity to interact. We found no evidence that D. mellitae excludes clams from the oral surface as both of the clams found on the oral surface were found on sand dollars with D. mellitae, and no clams were found on the oral surface of any of the 96 sand dollars without D. mellitae. Based on their distinctive overlapping valves (Fig. 1), we suspected these juvenile clams were Anadara (Scapharca) brasiliana (Lamarck, 1819). Adult A. brasiliana, which are known from St Catherines Island (Prezant et al., 2002), can be identified by the overlap of the left valve over the right (Ruppert & Fox, 1988; Mikkelsen & Bieler, 2008). To confirm this hypothesis we sequenced a portion of the mitochondrial cytochrome c oxidase I (COI) gene from two adult A. brasiliana and five juvenile clams (including the largest and smallest that we collected). We first isolated DNA from one individual and amplified and sequenced a portion of the COI gene using standard methods (Snowman, Zigler & Hedin, 2010) and the HCOI and LCOI primers from Folmer et al. (1994). Based on this sequence we designed taxon-specific primers (LCO1Ana: 50-CGGCATTAGTAGGAATTTCCTTAAG-30 and HCOI Ana: 50-GCCAAGAAGTGACAAACATACCCC-30) and used these to amplify and sequence a portion of the COI gene from all seven individuals (GenBank accession numbers JN656612– JN656618). Across a 458-bp alignment of these seven sequences, six nucleotide positions were variable. One adult A. brasiliana individual and three of the juvenile individuals had identical sequences, one individual differed from those four individuals by a single-nucleotide difference, one by two differences and one by three differences. The maximum divergence between specimens was 1.1%, and the mean divergence was 0.4%.


A combination of federal regulations and the growing concern for reducing rollovers and collisions has led automakers to offer an increasing array of passive and active safety technologies. This article offers a brief look at a number of technologies, with focus on lane departure and blind-spot detection systems. The article also discusses how automakers are layering some of the technologies on top of safety equipment that has already been introduced, creating a cocoon of safety surrounding the occupants of a vehicle.


DCC bandwidth in traditional SDH network could not meet the request of developing network. This paper presents the way of applying ML-PPP protocol into traditional DCC management in SDH network. A high bandwidth virtual link would be created by combining several physical links together with ML-PPP protocol. The test result proves that DCC bandwidth would be increased significantly by this way, so that the problem of DCC bandwidth shortage would be solved.


The proglycinin synthesized in E. coli JM105 comprised approximately 20 % of the total bacterial proteins, with a yield of 39 mg per liter of culture under the optimum cultivation conditions. The proglycinin was purified to homogeneity by salt precipitation, ion-exchange chromatography, and cryoprecipitation. The purified proglycinin self-assembled to a trimer with a secondary structure similar to that of the glycinin half-molecule from soybean seeds, and had properties of gel formation by heating and precipitation with calcium salt as the native glycinin and glycinin half-molecule do. This indicated that the E. coli expression system of glycinin cDNA may be used for the evaluation of the self-assembly and the food qualities of protein-engineered soybean proteins.


Tha nation's airports are taking a long hard look at their systems to determine whether they are vulnerable to the levels of disruption being forecast for Y2K. The Airports Council International (ACI) has developed an extensive Y2K checklist and has created a special Y2K page on its website (www.airports.org) to help ACI members ensure that all computer systems at their airports are fully year 2000 ready at the earliest possible date, prior to 1 January 2000. ACI is working closely with the International Air Transport Association (IATA) and other industry organizations to ensure that all aspects of the industry are fully involved.


The article examines the engraving by Ilarion Myhura devoted to Hetman Ivan Mazepa – the architect of Ukrainian churches. Attention is given to the political context and artistic methods of painting this and similar peaces devoted to Mazepa. The engraving is seen as a special form of the hetman panegyric within the 'mohylanska' tradition, which was dominant in the Kyiv-Mohyla academy from its establishment.


The Wnt/β-catenin signaling pathway controls intestinal homeostasis and is frequently deregulated in colorectal cancer (CRC) (for a comprehensive review, see [1]). By tightly regulating the levels and subcellular location of the β-catenin transcriptional co-activator, the Wnt pathway governs cellular proliferation in the intestinal crypt. Mutations in components of this pathway, most often in the adenomatous polyposis coli ( APC ) tumor suppressor, are found in approximately 90% of spontaneously arising CRCs. Moreover, germline mutations in APC cause familial adenomatous polyposis (FAP), an inherited cancer syndrome characterized by early onset of colon adenomas. In the absence of a Wnt signal, cytoplasmic β-catenin associates with a destruction complex of proteins containing APC, glycogen synthase kinase 3 beta (GSK3β), casein kinase 1 (CK1) and axis inhibitor proteins 1 and 2 (AXIN1 and AXIN2). Here, β-catenin is phosphorylated and subsequently targeted for degradation by the proteasome. An intact destruction complex ensures that Wnt/β-catenin target genes are repressed in differentiated cells. In the presence of Wnt, the destruction complex is inactivated, β-catenin protein levels increase and β-catenin is translocated to the nucleus to drive expression of growth-promoting genes including c-MYC and CCND1 . The APC occur CRC are believed, in part, to render the destruction complex inactive resulting in deregulated Wnt/β-catenin increased cellular proliferation. AXIN2 direct Wnt/β-catenin as to serve


As healthcare organizations turn to population health in order to more effectively manage the health and well-being of their patients, many need to ensure that these new strategies include a directive to improve the patient experience. Fortunately, healthcare systems can turn to an existing entity within its ranks, the health contact center, in order to execute a successful strategy and ensure that the individual patient never feels lost amongst the population crowd. Fran Horner from Singola Consulting and Susan Marks from Amati Health explore the ways in which population health and the health contact center work collaboratively to keep patient populations well cared for, healthy, and ultimately improve the patient experience for every individual.


Seven hundred and fifty‐seven consecutive patients undergoing a midline abdominal incision were stratified according to age, sex, type of operation and degree of operative contamination and were randomly allocated to mass closure of the abdominal wall with continuous 4 metric polydioxanone (PDX; 374 patients) or continuous 4 metric polypropylene (PPL; 383 patients). Wound infection was less common with PDX (PDX 3·5 per cent; PPL 7·0 per cent; P < 0·05) and there was one dehiscence in each group. The incidence of defective wounds in patients surviving 1 year was similar (7·7 per cent PDX; 9·7 per cent PPL) but the PPL suture had to be removed because of persisting wound pain or sinus formation in five patients. PDX is the preferred suture material for closure of midline abdominal incisions.


To let the optical system of an infrared life detector have a larger detection area,a new infrared dual field of view optical detection system is proposed.The optical system is a zoom system. Because its lens group zooms and compensates temperature by axial motion,its electromechanical system is simplified.The system has an operation wave band of 8 to 14μm,a focal range of 35 to 140 mm and a zoom ratio of 3.Since it uses Ge and ZnSe materials for its lens,its F number is greater than 1.1 which meets the cold shield efficiency of 100%.It has a modulation transfer function greater than 0.5 at the spatial frequency of 15 lp/mm.After the temperature range of the optical system and the parameters of its lens group are defined,the imaging quality of the optical system is evaluated with the OSLO LT optical design software.The result shows that the optical system can meet the practical imaging requirement.


Craig's Progress was commissioned by Mecklenburgh Opera. It was conceived as a modern-day opera buffa. Subtitled An Operatic Adventure Story, and with a libretto by Stephen Pruslin, the opera follows Craig's journey from naivety to wisdom, from comic-book character to real person. Five singers perform 49 roles as diverse as reindeer, bartenders, Gods, and planets, as well as an Ice Cream Vendor, a Gingerbread Witch, The Fiery Stoker, and many other characters. The combination of operatic and comic-book styles makes this fantasy-world both accessible and humourous.
Craig's Progress, was first performed in June 1994 at the Queen Elizabeth Hall, London.


Background Early stage (FIGO stage I‐II) endometrioid endometrial adenocarcinoma (EEA) is very common in clinical practice. However, patients with the early stage EEA show various clinical behaviors due to biological heterogeneity. Hence, we aimed to discover distinct classes of tumors based on gene expression profiling, and analyze whether the molecular classification correlated with the histopathological stages or other clinical parameters. Methods Hierarchical clustering was performed for class discovery in 28 early stage EEA samples using a special cDNA microarray chip containing 492 genes designed for endometrial cancer. Correlations between clinicopathologic parameters and our classification were analyzed. And the significance analysis of microarrays (SAM) array was used to identify the signature genes according to the tumor grade and myometrial invasion. Results Three tumor subtypes (subtypes I, II and III) were identified by hierarchical clustering, each subtype had different clinicopathological factors, such as tumor grade, myometrial invasion status, and FIGO stage. Moreover, SAM analysis showed 34 up‐regulated genes in high grade tumors, and 38 up‐regulated genes and 1 down‐regulated in deep myometrial invasive tumors. The overlap genes between these two high‐risk factors were markedly up‐regulated in subtype I, but down‐regulated in subtype III. Conclusion We have identified novel molecular subtypes in early stage EEA. Differential gene signatures characterize each tumor subtype, which could be used for recognizing the tumor risk and providing a basis for further treatment stratification.


(57) Abstract: The present invention, at least two different field of view, at least two image capturing apparatus for capturing detecting a marking device comprising at least one wheel feature being disposed on the wheel (5), evaluation using an optical measuring device and a device, an apparatus for locating the wheels and / or axial geometry of motor vehicles in a measurement space. Configuration is relatively simple and operation is relatively easy devices, wheel and shaft geometry data, the marking device (3, 4, 7, 8) further includes at least one body feature (7), at least 3 One of the resulting by and a reference feature device provided with a (3) reference feature (4). Measurement space is formed between the reference feature device as roadway plane. The position of the reference features (4) in the measurement space has been found in the evaluation device. Capture detection of the marking device (3, 4, 7, 8) is performed during the passage running of the vehicle, wherein at least one wheel to locate the wheel plane in at least three different rotational positions of the wheel (5) features (8) is capture detection and at the same time, at least one of the vehicle features (7) is capture detection in order to locate the vehicle motion coordinates. By using evaluation equipment, the wheel plane, the relative position of the vehicle moving coordinate, it is possible to locate at least a wheel and / or axial geometry.


Fast Congestion Notification (FN) one of the proactive
queue management mechanisms that practices congestion
avoidance to help avoid the beginning of congestion by
marking/dropping packets before the router's queue gets full; and exercises congestion control, when congestion avoidance fails, by increasing the rate of packet marking/dropping. Upon arrival of each packet, FN uses the instantaneous queue size and the average arrival rate to calculate the packet marking/dropping probability.This paper presents the Drop/Mark Activation Function, which is an internal (built in) function of FN marking/dropping probably function, and shows the conditions under which the FN will trigger a probabilistic packet marking/dropping. This paper shows that the FN's drop activation function is given by L(Ri, Qcur) =(Ri −μ).T−(Qopt −Qcur)which compares the predicted and required/allowed changes in the queue level, over a time period, to decide whether to attempt or
not to attempt packet dropping. L(Ri, Qcur) = 0 defines the set of the drop activation threshold , the set of (average rate, current queue size), (Ri, Qcur), points for which the required/allowed and predicted decrease/increase in the queue level exactly equal each other and that identify the boundary between the drop region (L(Ri, Qcur) > 0), the sets of points at which the packet dropping is attempted, and the no-drop region (L(Ri, Qcur) < 0), the set of
points at which the packet dropping is not attempted.


A fossil fruit body of Fomes fomentarius was found in Holocene deposits of the Odra River in the city of Wroclaw (SW Poland). The fungus was found among early Sub-Boreal oak logs.


The effects of addition of deuterium (D2) to conventional gases [Ne (92%)–Xe (8%) and He (70%)–Ne (27%)–Xe (3%)] on discharge characteristics were investigated in this work, with the aim of improving luminance and luminous efficiency as well as achieving low sustain voltage. When the gas-inlet amounts of D2 added to Ne–Xe or He–Ne–Xe gas-inlet mixture were varied from 0 to 0.1%, we measured the sustain voltage, the luminance, the luminous efficiency and the wall charge corresponding to each gas-inlet. The addition of extremely small gas-inlet amounts of D2 increased the number of electrons, which improves the Xe* density [Xe*(1s4)→Xe+hν(147 nm)]. As a result, luminance and luminous efficiency increased while the sustain voltage decreased.


Fairytales are widely famous and loved by different age groups. Good fairytales have the ability to transcend the readers to the exact time and space the author has in mind, ignite their imagination and interest, by using magic, characters imposing super-natural powers, and address universal human emotions which all people can relate with. This influential literature sometimes contains gender stereotypes which label the abilities and roles of each gender and create a notion of what is right and suitable for them. In my paper, I will address some critical issues present in old and famous fairytales, talk about the importance of fairy tales, and their use in psychology. Moving on, I will focus on four fairytales; two traditional ones, and two of the rewritings of those tales in a contemporary manner by Angela Carter. Later I will show the analysis of a survey I have conducted with the citizens of Armenia regarding the portrayal of women in fairy tales, and their preferences of types of fairytales to rear their children with.


e13016 Background: According to the National Cancer Institute, breast cancer is the most common form of cancer in the United States. Nearly 75% of patients with breast cancer have tumors that are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative. In 2017, the U.S. Food and Drug Administration (FDA) approved abemaciclib to treat adult patients who have HR+ and HER2- advanced or metastatic breast cancer. While the adverse events associated with abemaciclib have been well documented in clinical trials, it is unknown if adverse events, specifically diarrhea, impact adherence. The purpose of this study is to determine whether adherence to abemaciclib differs for patients who receive loperamide in welcome kits versus those who do not receive loperamide in welcome kits. Methods: This is a retrospective study of patients throughout the United States with HR+, HER2- breast cancer who received abemaciclib from a large specialty pharmacy from July 1, 2018 to December 31, 2019. Patients who received welcome kits (each welcome kit contains three boxes, each box contains ten 2mg tablets of loperamide) served as the intervention group; patients who did not receive welcome kits served as the standard of care group. Baseline characteristics of patients in each group were compared with t-tests for continuous data and the chi square test for categorical data. Medication possession ratio (MPR), dose reduction and dose omission rates in the first three months of taking abemaciclib were compared. Results: We identified 1,180 breast cancer patients who received abemaciclib. The intervention group had 317 patients, with an average age of 60.1 y (SD = 12.0); the control group had 863 members, with an average age of 58.7 y (SD = 11.8). Baseline characteristics did not differ significantly between groups, except for geography (p<0.001), as seen in the table. There was no significant difference (p = 0.858) in mean MPR between the intervention and standard of care groups. There were no significant differences in dose reduction rates (p= 0.390) and dose omission rates (p = 0.872) within three months of starting abemaciclib. Conclusions: Our findings suggest that patients who receive loperamide in welcome kits do not have better adherence to abemaciclib therapy. In this study, both groups showed high adherence to therapy, suggesting that the standard of care group manages diarrhea just as effectively as the intervention group. A welcome kit with loperamide did not impact a patient's adherence to abemaciclib therapy.[Table: see text]


Industrial accidents pose risks to the entire environment located in the area of influence of the enterprises, especially when they are affected by the atmospheric dispersion of pollutants emitted, as in the case of a nuclear power plant, where the concern with the evacuation of the population is the main priority in critical situations , which reinforces the implementation of actions to support emergency planning and its management, whose support tools, among them the computational modeling that, based on atmospheric models and geographic information systems, are essential in the decision making process. Thus, based on the Angra dos Reis nuclear complex and the impacts that may affect its surroundings, studies using the integrated use of computational platforms served to evaluate the risks and consequences of a hypothetical accidental event, including the calculation of the thermo- source of nuclear fuel, meteorological characteristics, mechanisms of atmospheric dispersion of pollutants, as well as socio-environmental aspects of the region. Meteorological data (wind regime) characterize the wind field from the WRF model, which subsidized the dispersion of radionuclides calculated in the HYSPLIT, information associated with socioenvironmental data (landslides, population density, etc.), incorporated in a GIS database. The results demonstrate the importance of the integrated use of computational systems as tools that support decision-making, potentializing the application of solutions that contribute to support actions and guidelines of planning and governance in emergency situations.


Show me a well-fed man in pinstripes arguing over ethics with a young thing in a T-shirt and. try as I might to be impartial. I can't help siding with the kid. It's the anti-establishment in me.


Objective To discuss the therapeutic strategy and the clinical efficacy of percutaneous cholecystostomy in treating high-risk patients with acute cholecystitis. Methods During the period of Jan. 2006-June 2008,percutaneous cholecystostomy was performed in 27 high-risk patients with acute cholecystitis,consisting of lithic cholecystitis (n = 21) and non-lithic cholecystitis (n = 6). Of 27 patients,percutaneous cholecystostomy via transhepatic approach was performed in 22 and via transperitoneal approach in 5. The 7 F drainage catheter was used. Cholecystography was conducted before the drainage catheter was extracted. Results Percutaneous cholecystostomy was successfully accomplished in all 27 cases,with a technical success rate of 100%. Postoperative patency of gallbladder drainage was obtained in 25 patients,with the relieving or subsiding of abdominal pain and the restoring of temperature and leukocyte account to normal range within 72 hours. In one patient,as the abdominal pain relief was not obvious 72 hours after the procedure,cholecystography was employed and it revealed the obstruction of the drainage catheter. After reopening of the drainage catheter,the abdominal pain was relieved. In another case,cholecystography was carried out because the abdominal pain became worse after the procedure,and minor bile leak was demonstrated. After powerful anti-infective and symptomatic medication,the abdominal pain was alleviated. The drainage catheter was extracted in 25 patients 6-7 weeks after the treatment. Of these 25 patients,12 accepted selective cholecystectomy,7 received percutaneous cholecystolithotomy and 6 with non-lithic cholecystitis did not get any additional surgery. The remaining two patients were living with long-term retention of the indwelling drainage-catheter. Conclusion Percutaneous cholecystostomy is a simple,safe and effective treatment for acute cholecystitis in high-risk patients. This technique is of great value in clinical practice.


Abstract The space-angle-energy dependent integro-differential equation of the neutron transport theory cannot be exactly solved analytically in its entire generality. Over the past three decades, there have been many research efforts to develop numerically efficient approximate methods to solve the neutron transport equation. In this paper, we will present a new approach to the neutron transport equation, which is suitable for numerical compiitations. To understand the limitations of the existing popular approximate methods, we first consider the exact solution of the one-speed transport equation in plane geometry


The method of synthesis and implementation into FPGAs (Field Programmable Gate Arrays) of Mealy FSMs (Finite State Machines) is proposed. Synthesis is based on the architectural decomposition and the multiple encoding. A set of states is divided into subsets based on a current state or a executed microinstruction. Then, states are encoded separately in each subset. The state is decoded in the second-level circuit based on the multiple code and the code of a current state or the code of a executed microinstruction. It leads to implementation of an FSM in double-level structure where utilization of both, LUTs (Look-Up Tables) and embedded memory blocks, is applied. It leads to balanced usage of hardware resources of an FPGA device.


Combined heat and power (CHP) is a technology with significant economical and environmental benefits. Proper sizing and operational strategy of CHP systems must take into account the time dependent character of electrical and thermal load requirements. Furthermore the CHP systems should be able to operate at off-design points with variable power and heat outputs. In this paper, the selection of type and combination of prime movers, their nominal powers and planning their operational strategy is performed. Three prime movers namely diesel engine, gas engine and gas turbine have been used to provide the required power and heat loads. Ambient conditions, and time dependent electrical/heat load curves are assumed to be the known variables, and thermal efficiency, engine exhaust gas temperatures, exhaust and fuel mass flow rate at partial load are estimated using relations obtained for prime movers mentioned in this paper. The presented approach successfully estimated the most economical combination of prime movers for a selected district heating plant.Copyright © 2004 by ASME


The long term data of dynamics of numerosity of pentatomid bugs (Eurygaster integriceps Put.) in Nicolaev region is shown. The influence of the preceding crops and sowing terms of winter wheat on population density of pentatomid bugs in the southern Steppe of Ukraine are given. Results of researches of efficiency of action of modern insecticides against of pentatomid bugs on winter wheat crops are presented


Objective To display human CD28 extra-cellular domain homodimer on phage using phage display technique and to detect its antigenicity and bioactivity. Methods Extra-cellular region of CD28 gene was amplified from Jurkat cell using RT-PCR and was then cloned into pComb3HSS vector. The recombinant phagemid vector pComb3H-CD28 was transfected into competent bacteria XL1-blue, then the transfected bacteria was co-infected with help phage VCSM13. CD28 extra-cellular domain homodimer was displayed on the phage surface. The antigenicity and bioactivity of CD28 displayed on phage was detected by ELISA, FCM and inhibition assay of lymphocyte proliferation(MTT). Results The recombinant phagemid vector containing human CD28 gene extra-cellular domain, pComb3H-CD28, was successfully constructed. CD28 was displayed on phage. ELISA and FCM detection showed that phage- displayed CD28 could bind to CD28Ab and could bind with CD28Ab by competing with CD28 on the surface of Jurkat cell. These data indicated that phage-displayed CD28 possessed antigenicity. Phage-displayed CD28 could also bind to rhB7-1 and CD80 on the surface of Raji cell, demonstrating that phage-displayed CD28 not only maintains its antigenicity but also possesses its native structure of binding to its ligand. In further, MTT inhibition assay showed that lymphocytes proliferation stimulated by PHA and CD28Ab could be inhibited by phage-displayed CD28, indicating that it has bioactivity of CD28. Conclusion The phage display system can display human CD28 extra-cellular domain homodimer with antigenicity and bioactivity.


This is a time of great debate about the future of Northern Studies in Canada. Most of those engaged in the debate believe that we need a new, rejuvenated vision for Northern Studies. One major change has already occurred: the establishment of the Arctic Council in 1996 gave new impetus to cooperation among the eight circumpolar nations involved. This cooperation has already changed the way in which we perceive and manage Northern Studies in Canada. I would suggest that membership in the Council is leading us inexorably towards another change in Northern Studies: formal recognition that modern Northern Studies are Polar Studies. One of the strong commonalties in science and technology among the Arctic Council nations is an interest in Antarctica - specifically in comparison to the roles of other Arctic Council nations. It concludes with recommendations on Canada and the Antarctic Treaty and on the way we should view Northern Studies in Canada. The paper is based on a recent report on a visit to the Ross Sea (New Zealand) sector of Antarctica (Adams, 2000). That report includes the text of the Antarctic Treaty and other related documentation.


The Discrete Element Method (DEM) approach is used to simulate flow of granular materials for a variety of mining industry applications. The next step in this approach is to combine several DEM particles into particle clusters using structural bonds and to allow them to break to simulate the comminution processes. Current progress in computer technology and development of parallel computing algorithms allows us to perform large-scale 3-D DEM simulations of the comminution process. Examples of these simulations, applied to SAG mills, will be presented in graphical and animation form. Specific studies determining critical size and critical shape are presented.


Identifies the years Tolkien used as a basis for moon phases and other celestial events in The Lord of the Rings as 1944–1945.


ABSTRACT Halfway through a 10-year monitoring program, NOAA continues to track biological, chemical, and shoreline profile recovery at nearly three dozen sites in Prince William Sound, Alaska. By s...


Abstract : Panel distributions have been characterized independently in terms of computable and controllable parameters. Thus, a methodology has been developed which will permit a conclusive establishment of the sensitivities of paneling parameters to aerodynamic estimation quality for a wide variety of paneling codes. It has been demonstrated that the global performance (input-output relationships, precision, and accuracy) of a panel method computer program can be established through calibration. Application of the sensitivity analysis developed herein to SURAIR (a Woodward constant pressure panel method derivative) has shown that it is possible to increase estimation accuracy without the commonly expected increase in computation cost.


Nowadays, customers demand faster customer service, and expect that organizations know them and provide appropriate services and recommendations for products quickly. Many organizations are reacting to these market needs by driving toward pervasive business intelligence, augmenting traditional business intelligence (BI) with the ability to capture, interpret and act immediately on data to make faster decisions. With pervasive business intelligence, organizations data warehouse changes to a system that can proactively and reactively interact with the business stakeholders, and it provides appropriate decision options to help marketers to respond and take action based on knowledge discovery in current integrated data. This work based on the literature review presents the Pervasive Business Intelligence state of the art and related areas, leaving open for proposing a conceptual framework to guide the development of activities of Marketing Intelligence. The analysis of large volumes of data is impossible without resorting to the appropriate software tools, making it essential to develop frameworks that help to automatically and intelligently, analyzing, interpreting and correlating data, enabling the development and selection of strategies for action (2). In order to assist companies in this exploration of data, concepts and tools for organizing information are critical, highlighting the Pervasive Business Intelligence (PBI) and Marketing Intelligence (MKTI) as pillars to support the decision-making. The economic decline is impelling organizations to examine ways of retaining customers, speed up their services, spending less capital be more efficient regarding their budgets, and observing regulations. Business intelligence (BI) is the ability to access data from multiple sources in an organization and deliver it to appropriate business users for analysis. Manage the performance of the business means know what questions to ask and have the facts at hand at time to answer them, and this is what business intelligence delivers. With pervasive business intelligence, organizations data warehouse changes to a system that can proactively and reactively interact with the business stakeholders, and it provides appropriate decision options to help marketers to respond and take action based on knowledge discovery in current integrated data. Pertinent and accurate information from relevant and reliable sources entails to be successfully processed. This implies that a company needs to be confident it has the right information, at the right time, and dissembled to right people (3). We propose a framework to guide the development of activities of Marketing. A framework of satisfying information needs for decision-making is complex and is compound by different activities to be exploited. This paper is organized as follows: after this introductory part we present related background concepts. Then, the main contribution is presented in terms of a framework proposal. Finally we draw some conclusions.


Dielectric properties of baked dough samples of various moisture contents, temperatures and densities were measured at 27 MHz with a parallel plate capacitor connected to an Impedance Analyzer (HP 4194A). As a basis for the dielectric prediction model, statistical equations were developed from measurements of the solid density and the solid dielectric properties of flour-water mixtures at various moistures between 2% and 100% moisture. A square root dielectric mixture equation was selected and combined with the regression equations to give modified prediction equations for the dielectric properties of baked dough as functions of moisture content and bulk density at room temperature. These prediction models were further developed by introducing temperature correction terms. These developed models successfully predicted the dielectric properties ofbaked dough at different moisture content, density and high temperature.


increases. Conversely, continuous drug therapy prevents relapse in bronchitis, and the longer the duration of therapy the more effective the preventive measure against relapse appears to be. It would seem that relapse in chronic bronchitis during the summer and autumn months is considerably reduced, if not entirely prevented, by continuous antibiotic therapy. Without such continued treatment about half of the bronchitics during a six-monthly review period may be expected to relapse, and this seems to occur irrespective of whether antibiotics were used continuously in the previous season or not. Once a severe exacerbation occurs, many bronchitics are often appreciably disabled for a long period unless the relapse is intensively treated with antibiotics. These appear to be adequately suppressive in controlling the effects of bronchial infection. The suppressive action of oxytetracycline is apparently effective only during the period of its administration, and does not seem to prevent or even delay the appearance of relapse following its withdrawal. The relapse rates during six winter months from November to April in patients treated without antibiotics are but little different from those occurring in the months from April to November. However, 80% of all relapses observed in the four treatment groups appeared between September and February. This may well be related to the climatic and atmospheric changes associated with the onset of autumn, particularly in highly industrialized communities. It would thus seem reasonable to initiate a six-months course of continuous broad-spectrum antibiotic therapy when the first significant relapse occurs. Since most of these relapses occur in the autumn and winter, such a course of treatment nlay well overcome the relapse itself and also prevent further deterioration during the winter months, when most bronchitics are mainly at risk. Also it may be anticipated that no further continuous antibiotic therapy may be required for about six months after completing this course of treatment. It would therefore seem that only one period of continuous prolonged treatment with oxytetracycline in a dosage of 0.5-1 g. daily for about six months-the actual duration depending on the time of starting the treatment-may be required to prevent incapacitating exacerbations and maintain many bronchitics in effective and useful employment throughout the whole year. Comment has already been made concerning the expense of prolonged therapy with the tetracycline group of drugs for a period of six months. If a course of antibiotic treatment is started at the time of the first major relapse and continued for six to seven months, as may be required, the total cost to the National Health Service would be about £45-£55, and would be occasioned but once in each year. The arguments already adduced for suggesting that such a course of treatment with a seemingly expensive drug may in fact be an economy when other aspects of national expenditure-such as National Insurance benefit, the cost of a hospital bed, etc.-are considered, now have added significance. No untoward difficulties or complications occurred in those patients on prolonged antibiotics; toxicity was minimal, significant drug resistance was not observed, and the development of bronchial or intestinal oxytetracyclineresistant coagulase-positive staphylococci and of monilia did not materially differ in any of the treated or control groups.


Acute respiratory distress syndrome (ARDS) is the most common severe pulmonary complication of the coronavirus disease 2019 (COVID-19). Although considered earlier in the pandemic to represent a different clinical entity than nonCOVID-19 ARDS [1], it is nevertheless estimated that ARDS is present in 75% of intensive care unit (ICU) patients with COVID-19 and in 90% of ICU non-survivors [2]. Importantly, autopsy data show that ARDS, as evidenced by findings of diffuse alveolar damage, is present either in all [3] or in the majority of decedents with COVID-19 [4]. The toll of pre-pandemic ARDS-related deaths in the United States was estimated at nearly 10,000/year [5]. With over 375,000 COVID-19-related deaths in the USA during the first year of the pandemic [6], the epidemiology of ARDS was likely transformed substantially [7]. Accurate accounting of the ARDS-related mortality burden during the COVID-19 pandemic can inform future preventive and interventional efforts, as well as health resource allocation. However, the impact of COVID-19 on ARDS-related mortality at a national level has not been quantified. We used the National Center for Health Statistics (NCHS) Multiple Cause of Death data set, which is available through the Centers for Disease Control Wide-ranging Online Data for Epidemiological Research (CDC WONDER) website [8] to obtain mortality and population data. The mortality data in NCHS are based on information from all death certificates filed in the 50 states and the District of Columbia, and provides up to 20 causes of death in addition to an underlying cause of death. We have identified decedents with a diagnosis of ARDS during 2015 2019, and with a diagnosis of COVID-19, ARDS, or both in 2020, listed among any of the 20 causes of death irrespective of the underlying cause of death, which could be ARDS, COVID-19, or other conditions (e.g., cardiovascular disease, etc.). ARDS and COVID-19 were identified by International Classification of Diseases, Tenth Revision, Clinical Modification codes J80 and J071, respectively. Negative binomial regression with log-link and robust standard errors was used on the 2015 2019 data to forecast the number of ARDS-related deaths in 2020. We then compared the number of observed vs. expected ARDS-related deaths in 2020. In addition, we examined the proportion of a diagnosis of COVID-19 among all decedents with a diagnosis of ARDS and reporting of a diagnosis of ARDS among all decedents with a diagnosis of COVID-19. We then repeated the later analysis within each of the Department of Health and Human Services (HHS) Regions. Data analysis was performed using R 4.0.5 (R Foundation for Statistical Computing, Vienna, Austria). The annual ARDS-related mortality and population data for 2015 2020 are detailed in Table 1. In 2020, there were 51,184 ARDS-related deaths, 384,536 COVID-19-related deaths, and 41,606 deaths with both in the USA. The predicted number of ARDS-related deaths for 2020 was 10,851 (95% confidence interval (CI) 9,714 12,120). The ratio of the observed vs. expected ARDS-related deaths was 4.71 (95% CI 4.62 4.82). A diagnosis of ARDS was reported in 10.8% of all COVID-19-related deaths, ranging from 8.2% (HHS regions 1 and 7) to 16.1% (HHS region 2). A diagnosis of COVID-19 was reported in 81.3% of ARDS-related deaths in 2020. The data on the proportion of a diagnosis of ARDS among decedents with COVID-19 within each HHS region are presented in Table 2. Our study shows that the COVID-19 pandemic was associated with nearly five-fold rise in ARDS-related deaths in the USA during 2020, and a diagnosis of COVID-19 was present in over 80% of all ARDS-related deaths that year. This magnitude of change is unprecedented in ARDS epidemiology. Nevertheless, this dramatic change is likely a substantial underestimate of the actual contribution of COVID-19 to ARDS-related mortality in 2020. Although ARDS was present, as noted earlier, in the majority of decedents with COVID-19 in autopsy studies [3, 4], a diagnosis of ARDS was reported only in about 1 in 10 of death certificates of all COVID-19-related deaths. The causes of the very low rate of death certificate-based ARDS diagnoses among COVID-19 decedents are unclear. However, this finding may reflect clinicians' uncertainties Manuscript submitted March 27, 2023, accepted May 4, 2023 Published online May 31, 2023


Human-wildlife conflict (HWC) arises when wildlife shares the same physical space with humans. HWC, particularly livestock predation results in great negative impacts both to pastoralist and carnivores. Various approaches including compensation, livestock guarding, translocation of the problematic predator, and predator-proof bomas (PPB) have been used to mitigate such conflicts. We assessed PPB in mitigating human-predator conflict in Loitokitok sub-county by focusing on its effectiveness, most problematic predator, community's perceptions, and comparing the PPB and traditional bomas characteristics. Data were obtained from 90 homesteads in Olgulului, Mbirikani and Kimana/Tikondo group ranches. Correlation and paired t-tests were used to analyze the data. Our findings suggest that the boma sizes correlated with the total number of livestock in the boma (r = 0.386, n = 90, p = 0.000) but not the number of people. Hyena and lion accounted for the highest loss of shoats and cattle, with hyena mostly killing shoats (37%) and lions preying largely on cattle (34%). The most problematic predator was as hyena (68%). We found positive relationships between the most problematic predator and total number of livestock (r = 0.319, n = 90, p = 0.002), and boma circumference (r = 0.295, n = 90, p = 0.005). Livestock predation was high in boma during the wet seasons (April, September, October and December). The erection of PPB reduced livestock predation by 91.11% (n = 45) and time spend guarding livestock at night. We recommend a continuous maintenance of the PPB as a long term solution to livestock loss at night and a close guarding of livestock during the day by adults to reduce day time predations.


AMERICAN PROPHET NEW ENGLAND TOWN THE MEMORY OF JOSEPH SMITH IN VERMONT keith A erekson department of history master ofarts in december 1905 a large granite monument was erected at the birthplace of joseph smith on the one hundredth anniversary of his birth this thesis relates the history of the joseph smith memorial monument from its origins through its construction and dedication it also explores its impact on the memory of joseph smith in the local vermont and national context I1 argue that the history of the joseph smith memorial monument in vermont is the story of the formation and validation of the memory of joseph smith as an american prophet nineteenth century mormons cor remembered a variety of individual memories of joseph smith that were aggregated through reminiscences hymns and commemorations into three dominant collective memories joseph smith as prophet martyr and vermont schoolboy during the first decade of the twentieth century these three memories of joseph smith were filtered through the social religious and political interests and concretized into the joseph smith memorial birthplace monument the dedication of the joseph smith monument on 23 december 1905 and the messages presented at the site by junius F wells over the next five years shaped a broader interpretation of joseph smith as an american prophet the impact of the monument in vermont is examined through a case study of royalton vermont vermonts onti V past had been aggregated into a tradition emphasizing the virtue patriotism and individuality ofvermonters vermonter Vermo and royalton residents responded to the joseph smith monument by concretizing their own memory of royalton as a typical new england town through monuments a town history and an annual town holiday competing memories of an american prophet and the new england town collided during construction of the royalton memorial library in 1922 and settlement of royaltons Roy division over the definition of a new england town validated the memory of joseph smith as an american prophet throughout the twentieth century the memories of an american prophet and new england town accommodated each other vermonts ti Ve validation of the memory of joseph smith as an american prophet represents a national transformation in the memory of joseph smith AMERICAN PROPHET NEW ENGLAND TOWN THE MEMORY OF JOSEPH SMITH IN VERMONT


A novel 3D computational model was developed for the turbulent particulate two-phase flow simulation in the rectangular channel. The model is based on the Eulerian approach applied to 3D Reynolds-averaged Navier–Stokes modeling and statistical Probability Distribution Function method. The uniqueness of the method lies in the direct calculation of normal and transverse components of the Reynolds stresses for both gas and particles. Two cases were examined: a conventional channel flow and grid-generated turbulence flow. The obtained numerical results have been verified and validated by the experimental data, received from the turbulent particle dispersion test. The computed values of the particles' turbulent dispersion and the maximum value of the particulate concentration distribution show good agreement with the experimental results. The examples are ranged from coal and other bulk material pneumatic transport, vertical fluidized beds, coal gasifiers, and chemical reactors.


Optical-parametric chirped-pulse amplification with a positive dispersive media for both signal pulse stretcher and idler pulse compressor was demonstrated. By compressing negatively-chirped idler pulses, high power sub-100 fs pulses were successfully obtained in this manner.


Introduction One of the most common conditions leading to impairment, particularly in the elderly, is osteoarthritis (OA). Most often caused by knee and/or hip OA, OA is the most prevalent articular disease in the developed world and a major contributor to chronic. OA is recognized as a major contributor to disability and impairment, and it has a significant socioeconomic cost due to medical and surgical procedures, as well as lost productivity. OA is a complex chronic illness that begins with joint cartilage disintegration and progresses to synovitis, subchondral sclerosis, and the development of peripheral osteophytes. A treatment option for osteoarthritis cartilage injuries is platelet-rich plasma (PRP) therapy, which is linked to a decrease in tissue inflammation. However, there is still a lack of clinical research on PRP administration's price, length of treatment, and possible application as a treatment for articular cartilage injuries. Objectives This study aimed to examine the clinical outcomes of patients with knee osteoarthritis, comparing the clinical results of The Western Ontario and McMaster Universities Arthritis Index (WOMAC) between PRP and HA intra-articular injection. Methods The medical term "PRP", "HA", and "Knee Osteoarthritis" were used in Pubmed and Google Scholar to discover studies of the efficacy of Intra‑articular PRP injection VS HA in decreasing WOMAC scores up to October 2023. Two independent reviewers excluded the non-RCTs and other clinical studies irrelevant to the study question. Seven remaining studies were reviewed and screened for inclusion based on relevance to the subject and outcomes. Results Based on seven studies in this review, two studies showed that intra-articular platelet-rich plasma has a superior outcome on decreasing the WOMAC score than intra-articular hyaluronic acid injection with significant. Five of seven studies demonstrated that PRP has better outcomes on WOMAC score, even if not significantly. Conclusions PRP intra-articular injection is a clinically meaningful improvement for patients with knee OA, with no significant difference between treatment groups


The purpose of this study was to determine the most optimal density of komet fish (C. Auratus) fry in rearing with a recirculation system. This study used a completely randomized design (RAL) with 4 treatments and 3 replications where the treatments were : treatments A : stocking density 1 fish/L, treatments B : stocking density 3 fish/L, treatments C: stocking density 5 fish/L and treatments D : stocking density 7 fish/L. Parameters observed were survival rate, absolute weight growth (PBM), absolute length growth (PPM), and blood glucose. The results showed that the average survival rate of komet fish was 99,62%, average PBM was 0,48 g/fish, average PPM was 1,47 cm/fish and blood glucose was 34,50-39,33 mg/dl. The best density for rearing komet fish was 1 fish/L.


In the U.S. campaign contributions by companies play a major role in financing election campaigns. We analyze contributions by companies before an election and stock market performance after the election for the presidential elections from 1992 until 2004. We find that (i) the percentage of contributions given to the winner in a presidential election and (ii) the total contribution (divided by market capitalization) have a significant positive impact on a company's stock market performance after an election. While under Clinton both factors were equally important, during the Bush-presidency the total contribution had comparatively more impact.


By virtue of the universal validity of the generalized Born-Oppenheimer separation, potential energy surfaces (PES`) represent the central conceptual as well as quantitative entities of chemical physics and provide the basis for the understanding of most physicochemical phenomena in many diverse fields. The research in this group deals with the elucidation of general properties of PES` as well as with the quantitative determination of PES` for concrete systems, in particular pertaining to reactions involving carbon, oxygen, nitrogen and hydrogen molecules.


The present invention relates to an automatic warehouse system, the present invention, a plurality of trays jeokchi portion is formed a plurality of cassette storage tray so that the object is jeokchi; A tray loading module which is provided on one or both sides of the tray, the cassette loading the fetch target tray into the cassette tray; Tray unloading module which is provided in the other side of the cassette tray unloading of the export destination tray and the cassette tray outside; To transfer the tray loading tray through the loading module by the enemy or the teeth, the tray transfer module for transferring the tray located at the enemy the tooth to the tray unloading module; And a main controller for controlling the operation of the tray delivery module for loading or unloading the tray according to the import or export signal of the tray. According to the present invention, a storage object is while keeping the tray in the state identified information from the received tray, it is possible to rapidly discharge the tray is required from the operator based on the information of the tray, it can quickly be made of storage and retrieval of the object this and the reliability and efficiency of the storage management object can be increased by. In addition, since the trays are kept in a stacked state in the tray cassette is to be able to hold the plurality of trays in a small space, the space utilization can be increased. In addition, since the trays are jeokchi the cassette tray by the tray conveying module can be made jeokchi operation and discharge operation of the tray quickly and accurately.


This book offers teachers guidance in helping children develop the mental and physical abilities used in the discovery and creation of meaning through drawing by: Giving students extensive experience with materials -- Keeping in mind developmental guidelines -- Planning lessons with clearly defined objectives and in carefully crafted sequence -- Choosing objects suitable for the given age group -- Fostering aesthetic qualities -- Motivating and responding to children as they draw. The book contains 23 detailed Lesson Plans for classes ranging from Kindergarten through Sixth Grade.


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 This research focuses on the company's financ ing constraints. Such companies have limited internal funding and difficulties in accessing external f unding in its investment activities. The sample used is a manufacturing company listed on the Indonesia's Stock Exchange. Once the importance of investment policy and cash management policy, then this study will be linking the two. The results prove that there is mutual influence between the investment policy with a cash management policy in companies experiencing financi ng constraints. Penelitian ini bertujuan untuk menguji secara empiris hubungan timbal balik antara kebijakan investasi dan cash holding pada perusahaan berkendala keuangan di bursa efek Indonesia periode 2004-2007. Hasil penelitian ini membuktikan bahwa adanya hubungan timbal balik antara kebijakan investasi dan cash holding pada perusahaan ini, tetapi peran cash holding sebagai sumber utama bagi kegiatan investasi tidak terbukti.


The CIP-project Able To Include (ATI) is run by partners from five European countries. The aim is to create a technical solution thus ensuring that people with intellectual disabilities can use applications to lead fulfilling, independent lives. ATI is developing an accessibility layer that will integrate with existent and future ICT tools. The integration of this accessibility layer will be tested in 3 different pilots in Spain, Belgium and UK, and in 3 different usage scenarios: leisure within the information society, mobility and labor integration. To optimize the design, ATI chooses a collaborative approach with the end-users, i.e. people with IDD. To achieve this, focus groups were set up with people with IDD and with caregivers of people with IDD. The main purpose of this research was to explore the experiences and the current knowledge of people with Intellectual Developmental Disabilities (IDD) regarding social media. This paper mainly focuses on the technological results of the focus groups held in Belgium. Researchers found that people with IDD have a great interest in social media. It holds a lot of possibilities, yet people with IDD also encounter several issues, either with the devices being used, or coming from the application itself. As communicating through social media seems to be a critical issue, the tools developed by ATI can be of great value. A human centered design, including the end-users by the means of focus groups, enables researches to produce customized designing solutions, taking into account the needs and the specific context of use for people with IDD.


A switch unit for inputting a feature is selected depending on the user's situation and; Information display section that displays the function of the selected camera to the user; And zoom lens driving unit to perform an operation for moving the zoom lens group to the proper shooting position, the lens composed of the front group lens driving unit for operating to drive the front group lens group of the zoom lens to fit the focus driving and; Detector which detects the focal length of the zoom lens and; The focal length of the detected zoom lens group and, when determining the relationship between the normal image capture distance to the focal length is shorter than the normal image capture distance, and proximity to the zoom lens group move to the focusing distance, the focal length-up if longer than the focusing distance, the normal photographing moving the zoom lens group to the distance and the focal length-up case is shorter than the focusing distance, the zoom which comprises a micro-controller that controls the operation to prevent the warning displayed to the user by the information display unit is the shutter operation camera in the automatic photographing switching device automatically performs the switching of close-up mode and the normal image capture mode and enables the free-up without mechanical operation, close to the same as the lens operation of the photographing and normal photographing facilitates the lens system design to, and can also provide the automatic photographing switching method of a zoom camera.


This document presents the main findings of the project Enabling Family Farming Organisations (FFOs) to champion rural women economic empowerment and resilience through associativism and cooperativism , funded by the Forest and Farm Facility. It is led by the World Rural Forum


In addition detecting circulating tumour cells (CTCs) in blood, the presence of multi-cellular clusters has recently been identified to carry further information pertaining to patient outcome. We present a label-free method of measuring the range and load of clusters in a blood sample using a size-exclusion rail operated by centrifugal microfluidics. A negative selection strategy first enriches clusters from a whole blood sample; these clusters are then processed along the rail where they resolve to a series of collection bins according to size. Analysis of the occupancy of these bins then provides metrics on the cancer-cell load carried in the blood.


Preface 1. Introduction 2. Conservation laws and differential equations 3. Characteristics and Riemann problems for linear hyperbolic equations 4. Finite-volume methods 5. Introduction to the CLAWPACK software 6. High resolution methods 7. Boundary conditions and ghost cells 8. Convergence, accuracy, and stability 9. Variable-coefficient linear equations 10. Other approaches to high resolution 11. Nonlinear scalar conservation laws 12. Finite-volume methods for nonlinear scalar conservation laws 13. Nonlinear systems of conservation laws 14. Gas dynamics and the Euler equations 15. Finite-volume methods for nonlinear systems 16. Some nonclassical hyperbolic problems 17. Source terms and balance laws 18. Multidimensional hyperbolic problems 19. Multidimensional numerical methods 20. Multidimensional scalar equations 21. Multidimensional systems 22. Elastic waves 23. Finite-volume methods on quadrilateral grids Bibliography Index.


We present a case of reversible diabetes insipidus in a 64-year-old man with multiple myeloma. Central diabetes insipidus developed in association with a myelomatous lesion of the clivus, but without evidence of macroscopic pituitary compression. Resolution of this patient's diabetes insipidus was observed following treatment of his myeloma. A 64-year-old man presented with bone pain and weight loss. Blood tests revealed serum IgA 12.8 g/L (normal range 0.8–4.0), serum free lambda light chains 857 mg/L (6–26), beta-2 microglobulin 7.5 mg/L (0.0–3.2), corrected calcium 3.41 mmol/L (2.10–2.55), albumin 41 g/L (38–52) and creatinine 134 umol/L (60–105). X-rays demonstrated multiple long bone lytic lesions. A diagnosis of advanced IgA lambda multiple myeloma (MM) was made and the patient commenced chemotherapy with cyclophosphamide, dexamethasone and bortezomib. On the day of his third weekly dose of the first cycle of chemotherapy, he required hospital admission with profound dehydration and hypotension. He reported that he had been passing six litres of urine per day and drinking copious fluids. In retrospect, he had noticed increased thirst and urine output for six months, but had not mentioned it previously. His regular medications at this time were aciclovir, trimethoprim/sulfamethoxazole, ezetimibe, allopurinol, aspirin, cilazapril and dexamethasone. Admitting blood tests showed a creatinine of 152 umol/L (60–105), corrected calcium of 2.22 mmol/L (2.10–2.55) and a sodium of 137 mmol/L (135– 145). His anti-hypertensive agent (cilazapril) was discontinued and he was rehydrated with IV fluids. An overnight water deprivation test was suggestive of diabetes insipidus (DI), with a urine osmolality of 288 mOsm/kg (normal >750) and a matched serum osmolality of 293 mOsm/kg (normal urine/serum osmolality >2.4). He then underwent a formal 7-hour water deprivation test, as per the local protocol.1 Despite being nil by mouth he continued to produce 75–200mL urine per hour. At the end of the test his urine osmolality was inappropriately low at 270 mOsm/kg with a serum anti-diuretic hormone (ADH) of only 0.8 pmol/L (normal >1.0). Following administration of 2mcg of IV desmopressin his urine osmolality increased to 359 mOsm/kg and urine volume reduced to 30mL/hour (Table 1). A diagnosis of central DI was made1 and nasal desmopressin prescribed. The patient reported resolution of his nocturia and return to a normal fluid intake. There was no evidence of anterior pituitary dysfunction and he had a morning serum cortisol of 430 nmol/litre (200–700). He had a normal plasma glucose and none of his medications were known to cause central DI. An MRI pituitary was arranged (Figure 1). The pituitary gland was normal, apart from absence of the posterior pituitary bright spot. There were mottled changes of the skull base, in particular the clivus, confirmed as lytic lesions on a subsequent CT head scan (Figure 2). The bone lesions were consistent with myeloma. On the MRI scan there was also anomalous cerebral vasculature with a primitive trigeminal artery that caused distortion of the pituitary gland.


Desorption by microwaves is an alternative to standard industrial processes for the regeneration of fixed-bed-adsorbers. There are several advantages to using microwaves as the heat supply, but the mechanisms of microwave desorption, especially if several components are present, still have not been analyzed. In this article experiments of multicomponent desorption of fixed-bed-adsorbers are presented. An overview is given about the different mechanisms appearing during the process.


The reservoir water content index calculation is an important task of geological logging. This paper overcomes the existing error at calculating the water content index with traditional method, implements a set of water content index calculation software with C# programming. It enables data import, create evaluation chart board for water content automatically, data storage and other functions, and after users manually draw partition lines, the software can accurately calculate the water content index of the given points and new points, and also can predict the properties for new reservoir points according to the calculated water content index. This software implements detailed evaluate information of reservoir water content, saves a lot of human resources and achieves office automation.


Abstract : Team Building creates a working atmosphere where characteristics are developed that enable the team to be effective. Construction projects that have successful safety programs have many of the same characteristics of effective teams. This thesis analyzes whether team building use affects safety performance for different sized projects. Comparisons are also made of safety practices based on team building use. The analysis is centered on the data collected in the 1996 and 1997 Benchmarking and Metrics surveys that were conducted by the Construction Industry Institute.


The system response to accidental islanding and effect on anti-islanding detection of distribution feeders with multiple distributed generation (DG) technologies (synchronous machine and inverterbased units) is one major utility concern associated with increasing penetration of DG. Studies have been conducted to evaluate the performance of anti-islanding detection through use of conventional voltage and frequency protection elements, and a non-detection zone (NDZ) defined in terms of real and reactive power mismatch scenarios. However, this NDZ applies to only synchronous generator DG technology, and efforts to characterize system behaviour and performance of anti-islanding detection for systems with mixed inverter and machine units have been limited. This paper investigates the effect of adding inverter-based DG to the system under various real and reactive power mismatch scenarios.


This work was supported in part by the College of Agriculture and Life Sciences, University of Wisconsin, and by grants from the
National Institute of General Medical Sciences (GM-20427) and the National Science Foundation (GB-31086). This is Paper 7 in the
series "Organization of Ribosomal Protein.


We present a modification of the relativistic phase shift method of determining the radio emission geometry from pulsar magnetospheres proposed by Gangadhara &z Gupta (2001). Our modification provides a method of determining radio emission altitudes which does not depend on the viewing geometry and does not require polarization measurements. We suggest application of the method to the outer edges of averaged radio pulse profiles to identify magnetic field lines associated with'the edges of the pulse and, thereby, to test the geometric method based on the measurement of the pulse width at the lowest intensity level. We show that another relativistic method proposed by Blaskiewicz et al. (1991) provides upper limits for emission altitudes associated with the outer edges of pulse profiles. A comparison of these limits with the altitudes determined with the geometric method may be used to probe the importance of rotational distortions of magnetic field and refraction effects in the pulsar magnetosphere. We provide a comprehensive discussion of the assumptions used in the relativistic methods.


A superhydrophobic cotton fabric exhibiting photocatalytic self-cleaning properties under visible-light was prepared by step-wise deposition of anatase TiO2, meso-tetra(4-carboxyphenyl)porphyrin (TCPP) and trimethoxy(octadecyl)silane (OTMS). The modified cotton fabrics not only exhibited excellent superhydrophobicity with a water contact angle of 156°, but also showed significant photocatalytic degradation of methylene blue under visible-light irradiation. The fabrics were characterized by FESEM, XRD, NMR and UV-Vis spectroscopy. Textiles with dual functionality of superhydrophobicity and visible-light photocatalysis are promising for a wide range of self-cleaning applications.


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