Tanja Kotro, Paivi Timonen, Mika Pantzar and Eva Heiskanen The Leisure Business and Lifestyle National Consumer Research Centre – Publications 2:2005 This report is a summary of a study on the leisure business cluster conducted by the National Consumer Research Centre. It is part of the OECD project on Knowledge Intensive Service Activities (KISA) co-ordinated in Finland by the Technology Agency of Finland, Tekes. The study describes the Finnish leisure business cluster from the perspective of the consumer market. The starting point of the project was to highlight the consumer perspective in the current debate on the experience economy. The leisure cluster is here defined as a field of business related to active consumers' leisure pursuits. Business in the field of active leisure and hobbies provides companies the opportunity to move out of saturated mass markets and into more demanding and specialized markets. Active leisure pursuits provide a growing market, in which Finland hosts a number of internationally recognized companies. Yet the diversity of leisure activities and the consumers' autonomy present a difficult challenge for entrepreneurs and business. The special nature of innovations in this field and the challenge this presents for technology development provide numerous opportunities for further research. The report illustrates how business that revolves around consumers' leisure pursuits needs to be based on an understanding of consumer lifestyles and everyday practices. In the report, this knowledge is termed "lifestyle knowledge". External business services and voluntary organizations have a central role in producing lifestyle knowledge. Design agencies, advertising agencies and market research produce knowledge that can be used alongside the companies' own product development, user research and media monitoring to produce lifestylerelated competencies. The interviews conducted for the study indicated that more use could be made of such intermediary services in Finland. Using such services can have positive effects over the entire product development process, and not merely when launching new products. In Finland, one can identify a number of interconnected small leisure business clusters. There is no single leisure business cluster in the country. The clusters are different in terms of ownership structure, the separation between manufacturing and service operations, and the nature of the products. We have located two clusters that both produce a turnover of approximately 2 000 million euros: the sports and outdoor activities cluster and the home and garden cluster. They are examples of consumer-oriented clusters that have evolved on the basis of widely popular hobbies and practices. These fields have generated new manufacturing industries and services in Finland. Experiences gained in the domestic market based on consumers' leisure practices hold the potential to generate new proficiencies for companies based in Finland.


In many real-life scenarios, stress-strength model is a significant level that notices efficincy in reliability system. Thus, this paper considers the stress–strength model with reliability estimation R=P(X<Y) based on the Distribution of Inverse Rayleigh (IRD). Few classical methods of estimation such as; Likelihood as Maximum (MLE), Uniformly Unbiased Minimum Variance estimator (UMVUE), and Moment method (MOM), and three types of shrinkage weight factors estimation methods were compared. Also, a simulation of Monte Carlo is utilized for comparing among proposed methods based on Mean Square Error (MSE).


Cancer chemotherapy has advanced from highly toxic drugs to more targeted treatments in the last 70 years. Chapter 1 opens with an introduction to targeted therapy for cancer. The benefits of using a nanoparticle to deliver therapeutics are discussed. We move on to siRNA in particular, and why it would be advantageous as a therapy. Specific to siRNA delivery are some challenges, such as nuclease degradation, quick clearance from circulation, needing to enter cells, and getting to the cytosol. We propose the development of a nanoparticle delivery system to tackle these challenges so that siRNA can be effective. Chapter 2 of this thesis discusses the synthesis and analysis of a cationic mucic acid polymer (cMAP) which condenses siRNA to form a nanoparticle. Various methods to add polyethylene glycol (PEG) for stabilizing the nanoparticle in physiologic solutions, including using a boronic acid binding to diols on mucic acid, forming a copolymer of cMAP with PEG, and creating a triblock with mPEG on both ends of cMAP. The goal of these various pegylation strategies was to increase the circulation time of the siRNA nanoparticle in the bloodstream to allow more of the nanoparticle to reach tumor tissue by the enhanced permeation and retention effect. We found that the triblock mPEG-cMAP-PEGm polymer condensed siRNA to form very stable 30-40 nm particles that circulated for the longest time – almost 10% of the formulation remained in the bloodstream of mice 1 h after intravenous injection. Chapter 3 explores the use of an antibody as a targeting agent for nanoparticles. Some antibodies of the IgG1 subtype are able to recruit natural killer cells that effect antibody dependent cellular cytotoxicity (ADCC) to kill the targeted cell to which the antibody is bound. There is evidence that the ADCC effect remains in antibody-drug conjugates, so we wanted to know whether the ADCC effect is preserved when the antibody is bound to a nanoparticle, which is a much larger and complex entity. We utilized antibodies against epidermal growth factor receptor with similar binding and pharmacokinetics, cetuximab and panitumumab, which differ in that cetuximab is an IgG1 and panitumumab is an IgG2 (which does not cause ADCC). Although a natural killer cell culture model showed that gold nanoparticles with a full antibody targeting agent can elicit target cell lysis, we found that this effect was not preserved in vivo. Whether this is due to the antibody not being accessible to immune cells or whether the natural killer cells are inactivated in a tumor xenograft remains unknown. It is possible that using a full antibody still has value if there are immune functions which are altered in a complex in vivo environment that are intact in an in vitro system, so the value of using a full antibody as a targeting agent versus using an antibody fragment or a protein such as transferrin is still open to further exploration. In chapter 4, nanoparticle targeting and endosomal escape are further discussed with respect to the cMAP nanoparticle system. A diboronic acid entity, which gives an order of magnitude greater binding (than boronic acid) to cMAP due to the vicinal diols in mucic acid, was synthesized, attached to 5kD or 10kD PEG, and conjugated to either transferrin or cetuximab. A histidine was incorporated into the triblock polymer between cMAP and the PEG blocks to allow for siRNA endosomal escape. Nanoparticle size remained 30-40 nm with a slightly negative ca. -3 mV zeta potential with the triblock polymer containing histidine and when targeting agents were added. Greater mRNA knockdown was seen with the endosomal escape mechanism than without. The nanoparticle formulations were able to knock down the targeted mRNA in vitro. Mixed effects suggesting function were seen in vivo. Chapter 5 summarizes the project and provides an outlook on siRNA delivery as well as targeted combination therapies for the future of personalized medicine in cancer treatment.


In this work two versions of Oauth have been analyzed, the protocol OAuth 1.0a and the newer framework OAuth 2.0. A higher version number is often considered a good thing, but OAuth 2.0 has encountered much criticism. It has been criticised of not being safe enough while OAuth 1.0a was criticised of being very complicated protocol to implement, which has stopped it from growing as expected. The following problem is solved with OAuth: a resource owner has resources on a server. A third party would like to use some of these resources in the resource owner's name. OAuth solves this by letting the resource owner authenticates at the server and agree that the third party is authorized to access the resources that the resource owner possesses. The result of this work led to an implementation of an OAuth client to LinkedIn on PMCG Scandinavia AB's project portal. The result is an OAuth 2.0 solution that gives LinkedIn users the ability to log in to the project portal through LinkedIn. LinkedIns OAuth 2.0 solution was considered to be sufficiently safe and much easier to implement and maintain. (Less)


The paper is devoted to the historical aspects of actuarial methods. The aim is to fix regularity in that development, which can explain some specific features of the modern approach to actuarial science. That approach consists of understanding actuarial methods not as technical tools, but as a universal technique of risk and financial management for insurers. There is a comparison between «old» and modern approaches to actuarial science in this paper.


: The success of any business depends on the rational management of the processes taking place in an organization. The optimal application of all types of the resources: material, intellectual, and technological, allows achieving the desired goals in the shortest and the most economical way. The information technologies transformed the understand-ing of a communication system, allowed managing the processes at a distance, forming and transforming the information in a new way. Despite the opportunities appeared, most top managers of the companies continue to rely on the traditional classical principles and methods of management. It is caused by the established long-standing habits and the unwillingness to change to keep up with the times. Moreover, there is still quite a few of practical information that could be taken as the basis for decision making in the sphere of modern management. The paper considers various approaches to the organization of distance activity in the conditions of the information economy, presents the characteristics of open-type organiza-tions, their advantages, and disadvantages. The authors indicate the main reasons for the transition to the remote management, The main steps for the successful implementation of the activity in the modern conditions are listed, the criteria for the transition to the remote management, both for new and existing organizations, are identified. The restrictions on the types of activity hampering the process of a changeover from the traditional form of management to the remote (virtu-al) one are indicated. The paper displays the scheme of decision-making and the method of scenario analysis of the key factors for the successful implementation of the remote management mechanism by an "open" organization. The approb a-tion of the results suggested was carried out by the operating company. The authors presented the expert assessment of the main criteria of the operating efficiency, raised the questions for the further study of the problem of effective management of an organization using the remote principles.


. The September-October 1989 flank eruption at Mt. Etna marked a change in the recent eruptive style of the volcano. Seismicity, at mid (order of months) and short (order of days) time, precethng the eruption onset has been analysed by means of D (scaling exponent), inferred t¾om the seismic b value, that represents the scaling exponent of fracture length distribution. Time evolution of D preceding the eruption onset revealed: a general increase of D (9 to 4 months prior the eruption onset), intermittent rates of D decreases and increases (4 to 1 month), steady values of D (1 month) and sharp decreases of D marking the eruption onset. Integration of these results with ground deformation data reveals that at Mt. Etna stress corrosion crack growth, enhanced by fresh magrm arrival, is a plausible mechanism for weakening the country rock, by promoting crack growth and the coalescence of maj or faults.


IP Address blacklisting [1, 2] works by storing a list of the origin of known spam and then ignoring further email sent from that IP address, under the assumption it is also spam. This approach has two problems: spammers are able to circumvent it by regularly switching IP addresses, and after spam has been sent from an IP address hijacked by a spammer, email sent by the unsuspecting computer user is now blacklisted as spam as well.


The notion that exercise is medicine dominated Canadian physical education in its nineteenth-century inception and continued to circulate through fitness discourses despite the introduction of movement education in the mid-twentieth century, which offered more progressive methods of child-centered teaching. Canada's approach to physical education in the postwar decades was affected by important transatlantic influences, not only in matters of national fitness but through numbers of émigrée female physical educators from Britain who played a significant role in the transfer and exchange of professional practices. Arriving in British Columbia—the end of the railway line—in the late 1950s and '60s, these women promoted movement education and gained considerable traction in schools and colleges. Ultimately, however, an increasingly gendered discourse pitted the female-centered tradition of child-centered movement education against a growing appetite for competitive sport-skill-based forms of physical education and biopedagogical interventions supported by an evidence-based medicine approach.


In the era of modern medicine fundamental scientific installation is emerged in the diagnosis of diseases of the kidneys, which are based on traditional diagnostic tools. The presented article describes the modern view on the possibility of diagnosis of kidney diseases, based on genetic studies. The necessity of active development for molecular diagnostic methods of kidney diseases is revealed, which not only complement the traditional methods of research, but also provide insight in point of view of the molecular pathophysiology. Further study of kidney diseases from a position of molecular biology will allow us to take a modern look at the pathogenesis of many diseases and solve a number of problems from the standpoint of personalized therapy that takes into account the genetic characteristics of the patient.


In this paper, a class of linear time invariant interconnected dynamical systems with constraints on the states and/or control inputs is considered. In this class, the interconnections are considered as perturbations acting in contradiction to the autonomy of the individual subsystems. A multilevel controller is designed to control the behavior of this system while satisfying system constraints. The upper level part of the controller is designed to balance or weaken the effect of the interactions, while the lower level decentralized controllers are designed to insure optimal subsystem performance as well as to satisfy system constraints. An example is given to illustrate the performance of the developed procedure.


Recently, substantial progress has been made in perovskite-based light-emitting devices (LEDs) with near-infrared, red, green, and blue emissions. However, short-wavelength perovskite LEDs targeted...


Presentation of the results of an experimental study investigating the effect of polymers on the imbibition process. Two sets of experiments, static and dynamic, were performed.


Despite the growing interest in electoral observation in Latin America, the region of greatest development activity in recent years (Cuellar and Thompson 2008; Pinilla 2008), we still lack of a consistent conceptual discussion about what we mean when we say «electoral observation». Further on, in the same direction, it is well known that the countries of the region call that activity in many different ways, so this has a great impact on the way we carry research on the subject. This paper reviews specifi cases of observations and discusses the most used conceptualizations on electoral observation in Latin America (Boneo, Carrillo and Valverde 2007; Thompson 2008; Munoz-Pogossian 2013). Finally, it presents a definition that includes each of its basic elements and, at the same time, avoids «concept stretching» to allow deeper knowledge on the subject (Sartori 1984).


It is acknowledged that access to tourism by persons with disabilities continues to be shaped by a variety of constraints that are not being clearly or consistently addressed by those in charge of tourism planning and management. Based on these assumptions, this chapter is focused on the identification of structural constraints and negotiation strategies that influence the decision and participation to travel for people with physical disabilities. To achieve these objectives, the chapter used a qualitative methodology, with the analysis and discussion of the information collected through in-depth interviews. Results may ultimately contribute to deepen the knowledge about the factors that influence people with disabilities travel choices, allowing to identify specific recommendations for improving the tourist supply chain and, consequently, for the overall tourist experience quality.


ABSTRACT: We report that some oedemerid beetles and longicorn beetles visited male flowers of the wild grapevine Vitis ficifolia var. izuinsularis on Miyake Island, off southeastern Honshu Island, Japan. We collected those beetles by beating inflorescences at night, though we had previously found no insects on the inflorescences in the daytime. We also used light traps to collect insects from the vicinity of inflorescences, and trapped many other insect species in addition to oedemerid beetles. Our results suggest that some oedemerid beetles are promising candidates as effective pollinators of the wild grapevine.


The purpose of this work was to study the sequence of the formation of phases during the synthesis of the compounds Ln/sub 3/M/sub 5/O/sub 12/ (where M = Al, Ga) from mixtures of oxides over a broad temperature range, as well as to ascertain the conditions for obtaining individual compounds. The starting materials used were rare-earth oxides (of LnO-1 grade), which contained no less than 99.95% of the principal substance, aluminum oxide (..cap alpha..-Al/sub 2/O/sub 3/, chemically pure), and gallium oxide (..beta..-Ga/sub 2/O/sub 3/, ultrapure). The diffusion in polycrystalline samples of the Ln/sub 2/O/sub 3/-Al/sub 2/O/sub 3/ (Ln = Dy, Lu) and Ln/sub 2/O/sub 3/-Ga/sub 2/O/sub 3/ (Ln = Nd, Cd, Lu) systems was investigated by local x-ray spectral analysis.


The notion of private highways, which must have seemed fantastic to Americans just a few years ago, was commonplace to our great-great-grandparents. Built in the 1790s in the growing Republic, the first toll roads stimulated commerce, settlement, and population. Fiscal constraints and insufficient administrative manpower led communities to search outside the public sector for help. During the 19th century more than 2,000 private companies financed, built, and operated toll roads. A glimpse at our history may provide a useful perspective on today's budding toll-road movement.


We investigated the effect of moderate NaCl on photosynthesis and water absorption in arrowleaf saltbush ( Atriplex triangularis ) under PEG-induced osmotic stress to understand the effect of NaCl on plant adaptation to drought stress. PEG-induced osmotic stress led to reduced water absorption and chlorophyll content, injured photosystem and growth and reduced biomass. The addition of NaCl at 10–40 mmol·L –1 could reduce water potential and osmotic potential, maintain a high turgor, alleviate the destructive effect of osmotic stress to the photosystem, ensure a relatively high rate of photosynthesis and plant growth, and thus increase the adaptability of the plant to osmotic stress.


After the introduction of fifth generation network, there are several prospects and encounters for the evolving technologies like Virtual Reality (VR) and Augmented Reality (AR). This paper emphases on the possibilities of 5G network and how 5G will integrate with Virtual Reality and Augmented Reality and Tactile Internet. Tactile Internet in AR/VR is intended to generate a model alteration from the content-oriented interactions (through internet) towards remote based connections by empowering synchronized broadcast of tactile data like vibration, touch, gestures, surface texture over wireless network with the regular audio and visual data traffics which are also transferred over wireless network. Finally, this research paper intends to provide an overall opinion on the use of Tactile Internet in AR/VR, and to recognize and examine the involved drawbacks and technical problems, and to provide the possible resolutions and to suggest upcoming research guidelines. Initially, opening with the future of Tactile Internet in AR/VR and recent developments in this field, this paper presents a comprehensive outline for Tactile Internet in AR/VR in the past the 5G Era including a Tactile Internet planning, the VR/AR planning, the core technical problems, the important application studies, how it can be possibly enable ground-breaking ways to use Augmented Reality and Virtual Reality. Later, we can see a complete evaluation of the present Tactile Internet progress by generally classifying them into two main instances; specifically, haptic feedback and portable AR/VR device using 5G network. Finally, learning about both Tactile Internet and Augmented Reality/Virtual Reality, we will learn how 5G can change the way Tactile Internet integrates and works with AR/VR that can make an impact in the ever-growing IoT world.


Many porous materials have high susceptibility magnetic gradients in the pores, due to the presence of iron or other magnetic materials. Thus if probe liquids are placed in the pores they exhibit fast decaying signals with a short T2 * . Usually the actual T2 of the liquids is also reduced, due the presence of paramagnetic ions in the pore walls. The usual solution in NMR is to measure an echo (or echo train) at short times. However, recent work [J. Phys.: Condens. Matter 19, 415117, 2007.] has shown that water/ice systems near a pore wall form rotator phase plastic ice, with T2 relaxation times in the region of 100 to 200 ms. Thus if a NMR cryoporometric measurement is attempted with a measurement time significantly less than 1 or 2 milli-seconds, the result is to make a measurement based on the phase properties of the brittle to plastic ice phase transition, not that of the brittle ice to water phase transition. This gives rise to artefacts of small pore sizes that may not actually be present. This work successfully uses a-polar liquids instead.


The University of North Carolina has announced a limited number of graduate assistantships In the dormitories open to qualified graduate women. The assistantships are open to women who hold a college degree and who present fitness for graduate work. Each appointee will serve as a dormitory counselor, assisting the head of residence in her services for for the welfare of individuals and the group. In addition to her counseling duties, the dormitory assistant keeps student personnel records supplementary to those in the office of the Dean of Women and serves as liaison between students and University administration. Experience In working with individuals and groups in college is a prerequisite. Selection is based on character, personality, college record, experience, recommendations and professional objectives. Application forms may be obtained from Dean W W. Pierson, Graduate School, University of North Carolina, Chapel Hill, N, C. Applications must be filed not later than May 15. "Wear Green"


We examine the impact of outside purchase contracts on firm risk and firm capital structure. We find that firms with more outside purchase contracts have less risky cash flows. Despite these less risky cash flows, firms with these contracts also have less financial leverage especially when they operate in high value-added industries. Examining firm financing decisions, we document that firms with more outside contracts are more likely to issue private securities. Our results are consistent with firms with more outside purchase contracts using less leverage to decrease the expected costs of financial distress on their explicit and implicit contracting parties.


OBJECTIVE:To apply primary survey of effects of DAL-1 in procession of proliferation,migration and invasion of NSCLC cell line by construction of experimental NSCLC cellular model which DAL-1 is steady inhibited. METHODS:To design and construct specific shRNA interference plasmid vectors targeted to DAL-1 gene mRNA. The constructed shRNA expression vectors of positive clones were validated by double-enzyme digestion and DNA sequencing. Detect the change of DAL-1 mRNA with Q-PCR and DAL-1 protein expression with Western blot,to screen the clone which DAL-1 was steady inhibited. The change of cell proliferation activity was detected by MTT assay. To evaluate changes of migration and invasion in DAL-1 silenced NCI-H460 cell by Transwell migration and invasion model. Analyze the relationship between DAL-1 and NSCLC invasion. RESULTS:The sequences and plasmid were identificated by double-enzyme digestion and DNA sequencing. The mRNA expression level of DAL-1 of T4 group decreased (87.41±1.994)% respectively of that in NCI-H460/TN; Western blot analysis showed the DAL-1 protein decreased (82.73±2.147)% of T4 group respectively of that in NCI-H460/TN as well. MTT assay showed that NCI-H460/T cell proliferation was significantly enhanced compared with that in NCI-H460/TN (P=0.000). The capabilities of migration and invasion of NCI-H460/T cell significantly enhanced detected(P=0.000). CONCLUSIONS:NCI-H460/T cell line which had successful and stable inhibition of DAL-1 expression is established successfully. Silencing of DAL-1 gene can enhance the proliferation,migration and invasion of NCI-H460 invitro,the DAL-1 expression can inhibit the proliferation,migration and invasion of NSCLC.


Stability analysis of Volterra-Runge-Kutta methods based on the basic test equation of the form y(t)=1+λ∫ 0 t y(s)ds (t≥0), where λ is a complex parameter, and on the convolution est equation y(t)=1+∫ 0 t [λ+σ(t−s)]y(s)ds (t≥0), where λ and σ are real parameters, is presented. General stability conditions are derived and applied to construct numerical methods with good stability properties. In particular, a family of second-order V 0 -stable Volterra-Runge-Kutta methods is obtained


The paper analyzes the cause of low-efficiency of traditional projects,points out its shortcomings in management mode,puts forward the project SCM mode and discusses the basic concept,operation mode and support conditions.


Of the 10.7 million world refugees in 2013, 50% were children.1 The prevalence of developmental disability among refugee children is unknown. However, the disruption of families and education, in addition to the witnessed traumatic events, that often accompany the refugee and resettlement experience are known to impact cognitive, social, emotional, and physical child development.2 Meanwhile, an estimated 16% of children around the world have developmental-behavioral disabilities, but less than one-third that total number are thought to be detected and directed to the appropriate intervention, likely in part due to inadequate screening.3 Difficulty with adequate screening is compounded within refugee populations, for whom differences in culture and language often present barriers to the use of commonly used screening tools. This paper aims to explore the ways in which the refugee experience affects cognitive and social-emotional development of refugee children resettled in high-income countries; it will then consider refugee perspectives of developmental screening and culturally/linguistically-appropriate methods of developmental screening of refugee children in a primary care setting in order to most effectively and accurately identify children at risk for developmental delay to ensure timely referral for early intervention.


This paper discusses the path towards asb- tractive summarization and proposes a new knowledge-based methodology called K- BABS as a step forward on this path. We pro- pose to use both world knowledge, to identify useful content, and task knowledge, to filter out unreliable content, to generate more ac- curate summaries. This approach was imple- mented for guided summarization. The eval- uation shows that, used in combination with a state-of-the-art system, our K-BABS system significantly improves content coverage in the summaries.


The oriental beetle Anomala orientalis (Waterhouse) is one of the most destructive pests of turfgrass in the northeastern United States. Larvae feed on the roots of a variety of hosts, including most grasses, blueberry (Vaccinium sp., section Cyanococcus), cranberry (Vaccinium sp., subgenus Oxycoccus), raspberry (Ru bus sp., subgenus Idaeobatus), strawberry (Fragaria x ananassa), and ornamental plants, as well as sugarcane in Hawaii (Alm, et al., 1999, Alm, et al., 2012). High larval populations can destroy turf and damage fully grown nursery stock and containerized plants (Alm, et al., 2012, Pierce 2012). Larvae have been inadvertently shipped to new locations in containers and in balled nursery stock and/or sod (Alm, et al., 2012). Adults feed on grass blades and the flowers of pe tunias (Petunia sp.), dahlias (Dahlia sp.), hollyhock (Alcea sp.), phlox (Phlox spp.), Japanese iris (Iris ensata), and roses (Rosa spp.), but are not considered to be serious pests (Friend 1929, Hallock 1933). The oriental beetle is probably a native of Japan that arrived on the Hawaiian Island of Oahu before 1908 (Tashiro 1987, Vittum, et al. 1999). It is believed to have arrived in New Haven, Connecticut, in 1920 as a stowaway in balled nursery stock (Tashiro 1987). The beetle's U.S. distribution was examined by Alm, et al. (1999), who reported its presence in southeastern New Hampshire, Cape Cod and Central Massachusetts (widespread), Ohio (around Painesville on Lake Erie), New Jersey (widespread in blueberry plantings), Delaware (widespread), Maryland (widespread), Virginia (around Richmond and Arlington) and North Carolina (around Asheville). Single captures were recorded from Maine, South Carolina, Tennessee, and West Virginia (Alm, et al., 1999), though specific localities were not given and no further information could be located. Recent literature reports the oriental beetle from Maine to South Carolina, west to Wisconsin (Alm, et al., 2012). In addition to the single South Carolina capture presented by Alm, et al. (1999), Harpootlian (2001) reported a single specimen from the state, collected in June from Spartanburg. As of 1999, this record represented the southernmost 64 ENTOMOLOGICAL NEWS


During my fieldwork, I studied more than 50 incidents of blasphemy accusations closely and surveyed many others from a distance. One striking commonality between almost all the cases I came across was that they started within microlevel interpersonal relationships between people known to each other. While wider religious and nationalistic narratives that enable blasphemy accusations and punishments to take place are constructed and promulgated at structural and societal levels, it is within everyday interpersonal relationships that these narratives are acted out— relationships characterised by prior familiarity and hierarchical power relations, built on symbolic and conceptual boundaries. I focus on the everyday and the interpersonal to answer two interrelated questions: 1) what triggers blasphemy accusations; and 2) why are certain people targeted with these accusations? The discussion will show that accusations of blasphemy are often triggered by perceived transgressions of hierarchical symbolic boundaries and are made against expendable familiar others.


The bachelor's thesis is concerned with activization of seniors under the conditions of institutional. The theoretical part of this bachelor's thesis provides delimitation of these terms: advanced age, institutional care, activization of seniors. In the practical part there is firstly introduced Home for the Elderly "Cerna Hora", in which qualitative research was executed. The aim of this research is to find out, through interview with the help of a manual, whether the activization of seniors in the Home of Elderly "Cerna Hora" is satisfactory from the perspective of the seniors and the staff. The results of the research are then evaluated and the acquired information brings several im-pulses to improve services.


Self-emulsifying microbubbles, especially designed to increase the contrast of ultrasound images by the inclusion of perfluorocarbon molecules, have been studied by thermal analysis techniques. The microbubbles were made of a blend of gas (20%), surfactants (50%) and water (30%). The surfactants were mixtures of polysorbate-85, Span-80, poloxamer 188, glycerol and fluorinated surfactant (Zonyl®). Microbubbles have been characterized by means of diffusion light scattering and optical imaging. The effect of Zonyl® on encapsulation rate, as well as gas vaporization temperature and gas release temperature, has been assessed by means of Differential Scanning Calorimetry (DSC) and Thermogravimetric Analyses (TGA). Microscopy and laser granulometry techniques have been also carried out for each formulation in order to determine the number of microbubbles and their size, respectively. Moreover, stability of the emulsions has been evaluated by DSC and confronted with the results obtained from the ultrasound experiments. Average microbubble concentrations of 7.2 × 107 and 8.9 × 107 per mL were obtained for perfluorohexane and perfluoropentane based emulsions, respectively. The present study demonstrates that the amount of encapsulated perfluorocarbon increases and the gas evaporation temperature decreases with the concentration of Zonyl®. Furthermore, the best ultrasound contrast images have been obtained in vitro with the samples containing the lowest Zonyl® concentration. An explication regarding the role of Zonyl® in the emulsion/microbubbles preparations is proposed here in order to optimize self-emulsifying microbubble formulation for pharmaceutical development.


[Objective] The research was to know summer sun-bathing habitat selection of Brown-eared pheasant(Crossoptilon mantchuricum).[Method] Sun-bathing habitat selection was studied by using Line transects of systematic sampling during the late breeding period in Beisi Mountains of Huanglong Mountains Nature Reserve,Shaanxi Province,China from July to August 2007.Nineteen ecological factors of thirty-six sun-bathing sites used by Brown-eared pheasant and ninety-six random plots were measured during 8 transects crossing the entire study area.[Result] The results showed that Brown-eared pheasant preferred sun-bathing sites in areas characterized by broadleaf forest,cover(30%-50%),diameter(10-20 cm),density(0.05-0.10 plant/m2)and height(10 m)of trees,cover(50%),height(1.5 m)and density(5 plant/m2)of shrub,cover(30%)and height(10 cm)of grasses,altitude(1 400 m),slope degree(30°),sunny slope,upper slope,ridge,distance to human disturbance(500 m),water source(500 m)and edge of woods(500 m),sheltering class(10%).Resource selection function was a log-linear model and the overall classification model was successful to distinguish the sun-bathing sites from random ones at probability of 94.7%.The key factors notably influenced sun-bathing habitat selection were sheltering class and height of grasses,the secondary key factors were distance to water source and cover of grasses.[Conclusion] The key and secondary key factors of sun-bathing habitat selection have contributed to the understanding of environment characteristic and selection mechanism on sun-bathing sites of Brown-eared pheasant.


Since obesity and poor fitness appear to be unfavorable for both cardiovascular health and coping with viral infections such as COVID‐19, they are of specific interest in light of the increased risk for cardiovascular and respiratory events now seen after infection with SARS‐CoV‐2. The aim of the present study was therefore to investigate how body mass index (BMI) and cardiorespiratory fitness (CRF) in late adolescence are associated with the risk of cardiovascular disease (CVD), respiratory disease, and mortality after COVID‐19.In this study, 1.5 million 18‐year‐old Swedish men with BMI and CRF measured during enlistment for military service 1968‐2005 were included. Hospitalized and non‐hospitalized COVID‐19 cases were identified through the Patient Register or positive PCR tests, and age‐matched with non‐infected controls. CVD, respiratory disease, and mortality after COVID‐19 were divided into: <60d, 60‐180d, >180d post‐infection. Cox regression models were used.Hospitalized COVID‐19 cases (n=9,839), compared to controls, had >10‐fold, 50 to 70‐fold, and >70‐fold hazards of CVD, respiratory disease, and mortality over the initial 60 days post‐infection with little variation across BMI or CRF categories. The elevated risks persisted at declining levels >180 days. For non‐hospitalized COVID‐19 cases (n=181,822), there was a 4‐ to 7‐fold increased acute mortality risk, and high CRF was associated with lower risk of post‐infectious respiratory disease.The high hazards of adverse outcomes during the first two months after COVID‐19 hospitalization, and across BMI and CRF categories, declined rapidly but were still elevated after six months. High adolescent CRF was associated with respiratory disease after COVID‐19 without hospitalization, which gives further support to the health benefits of physical activity.This article is protected by copyright. All rights reserved.


A polymeric precursor, polysiloxazane (PSON), for SiCON ceramics has been synthesized by the partial hydrolysis of MeViSiCl2, MeHSiCl2 ,a nd MeSiCl 3 followed by ammonolysis reaction of the hydrolyzed inter- mediates with NH3. The structure and thermal properties of the polymeric precursor were investigated by means of Fourier transfer infrared spectra (FTIR), 1 H-NMR, 29 Si-NMR, gel permeation chromatography, and thermogra- vimetric analysis. The structure of the SiCON ceramics derived from the pyrolysis of PSON was characterized by FTIR and X-ray diffraction. The as-synthesized PSON pro- duced mainly a-Si3N4 crystalline phase during pyrolysis at 1500 � Cu nder N 2 atmosphere, whereas when pyrolyzed at 1500 � C under Ar atmosphere, crystalline phases of a/b-SiC and/or a-Si3N4 were detected. V C 2012 Wiley Periodicals, Inc. J fAppl Polym Sci 126: 853-859, 2012


For the needs of target acquisition and edge extraction under complex scenes, a method based on layer by layer segmentation is proposed. First of all, morphological reconstruction technology is combined with ant colony edge detection method to execute pre-segmentation to get the foreground that targets locate. Secondly, line scanning technique is used to divide foreground into several parts for further segmentation. And then, mean difference characteristic is adopted to determine seed point, with which region growing algorithm is applied to find true targets. Finally, active contour method is used to find out the edge of targets. The experimental results show that our method is effective in finding the target and extracting its edge under complex scenes.


In the readout electronics of the Water Cerenkov Detector Array (WCDA) in the Large High Altitude Air Shower Observatory (LHAASO), both high-resolution charge and time measurement are required over a dynamic range from 1 photoelectron (P.E.) to 4000 P.E. for the PMT signal readout. In this paper, we present our work on the design of time discrimination circuits in LHAASO WCDA, especially on improvement to reduce the circuit dead time. Several approaches were studied through analysis and simulations, and actual circuits were designed and tested in the laboratory to evaluate the performance. Test results indicate that a time resolution better than 500 ps RMS is achieved in the whole large dynamic range, and the circuit dead time is successfully reduced to less than 200 ns.


In order to thoroughly understand and satisfy the Al-Mg alloy welding technical in polyethylene project,using double-face synchronization TIG welding technology research and analysis the material welded joint mechanic performance characteristics.Based on repeatedly welding mechanic analysis and the assumed welding procedure and method,the research presented that the established welding procedure and method applied to the Al-Mg alloy material.And a reference for the other similar alloy material welding was supplied.


Labor Contract Law revises and completes the open-ended labor contract system and rationally regulates the way of breaking off open-ended labor contracts and protects rights and benefits of labors.


This theoretical essay concentrates on a reflection about the multiple possibilities that unfold due to the interactions in cyberspace. As a goal, we stress the actuality and identify possible lines of flights; it is an attempt to chart areas still to come, proposing alternatives that will enable the expansion of the human conscience. Cyberspace is shaped like Deleuze and Guattari's rhizome, and is filled with lines and points that interconnect continuously. Cyberspace is full of links, multiple entryways and exits, aggregating structures that sometimes accrete into bulbs and sometimes into tubercles. We were able to see lines of flight, alternatives for the expansion of the collective conscience and for the construction of a new society. In an attempt to proceed with the rhizome, there is no period, only ellipses...


The principle of cutting and splitting glass substrates of TFT-LCD and the impacts of craft parameters on cutting quality, such as scribe-wheel angle, cut pressure, press amount are studied in this paper. When scribe-wheel velocity is 300 mm/s, and press amount is 0.14 mm, the 120 °and 130 °scribe-wheels are used to cut glass substrates, the result is that cut depth of the 120 °scribe-wheel is 5~10 μm deeper than that of the 130 ° scribe-wheel. When cut pressure is determined, cut depth is deeper as press amount becomes larger. Cut pressure is a main factor which results in lateral crack's appearance. Under the same condition, for the 120 ° scribe-wheel, the lateral crack appears at the 0.18 MPa cut pressure; for the 130 °scribe-wheel, it appears at the 0.28 MPa cut pressure. That is, the smaller scribe-wheel angle is, the easier lateral crack is to appear. Press amount has little effect on lateral crack.


The essence of punishment is to inhibit wicked idea and induce goodness by punishing the student of his immoral behavior and making the student produce sense of shame so as to reach the purpose of education. The application of punishment must be followed by five principles and a few notes.


This work aims at providinga mathematical model of a furnace with forced flow of combustion products is developed. For this, a few variables were considered, such as: the combustion on grate (chemical equilibrium); the combustion products flow along the channels with pressure losses and heat transfer (by radiation and convection); the heating of the walls; the entrance of the secondary air; the displacement of the work point displacement by the characteristic of the ventilator; and the furnace transient regime operation. The coupled model includes several equations types, such as, the ODE's, and the PDE's non linear algebraic. The algorithm uses the different numeric methods with complex connection among them, when one method is applied inside another. The numeric simulations of transient regime reveal the causes of the furnace abnormal operation. This work also identified the: sketched safety's operational regimes; and determined the characteristics of the influence of the fuel consumption oscillations on the furnace. The procedure of abnormal phenomena deviation.


Radiopharmaceuticals containing 99mTc, a gamma emitting radionuclide, are commonly used in nuclear medicine to image specific organs for the purpose of diagnosis. Following injection of a chemical complex of this isotope and concentration of the activity within the organ of interest, scanning with a gamma ray camera provides an image from which diagnostic information can be obtained. Although, in most instances the composition of the injected radiopharmaceutical is known, the chemical form of the agent that is actually responsible for the image has not been identified and may represent an altered form due to in vivo reaction. Sensors that could be implanted in specific organs in order to specify the chemical form of the radioactive complex that is imaging an organ would be especially useful. In order to accomplish this goal, sensors for in vivo monitoring of imaging agents that are used in nuclear medicine are being developed. Such sensors must be multiwavelength since chemical information is contained in the spectrum of agents. A brief outline of the results of our efforts to make highly efficient catheter-sized absorbance sensors is presented.


The energy-saving environmental-protection two-grinding one-burning method iron ore cokeless iron making and cement clinker producing technology comprises the following steps: adding ingredients of anthracite or bitumite, a desulfurizer, a catalyst and the like to weakly magnetic iron ore which are difficult to select, such as limonite and the like, ball-milling them, adding an adhesive to the resulting ball-milled material, compacting to obtain bricks or tiles, coating a slurry on the formed bricks, sending them to a furnace, drying, sintering, reducing, and cooling; and carrying out fragmentation and air separation on the cooled core blocks under the protection of nitrogen, recovering separated light materials to reuse, obtaining secondary light materials which are the cement clinker, and carrying out three level magnetic separation on residues to obtain high purity iron powder and spongy iron According to the technology, wastewater and waste residues are not discharged, energy consumed by smelting accounts for 1/5 of energy consumed by present production of the spongy iron, and the addition of the desulfurizer to ore makes tail gas discharge reach national discharge standards. If the technology is adopted by a cement mill, the cement clinker can be produced with same energy consumption, and the spongy iron, and high grade iron powder or iron blocks which are badly needed by China can be produced to alleviate the import pressure of China, so benefits are good.


The concept of three-terminal MESFET varactor is presented and compared with the two-terminal type MESFET varactor. Both types of MESFET varactor are employed in an active bandpass filter to tune the center frequency of the passband. Tuning performances including the elecmcal tuning and the optical tuning are compared.


We present LightRel, a lightweight and fast relation classifier. Our goal is to develop a high baseline for different relation extraction tasks. By defining only very few data-internal, word-level features and external knowledge sources in the form of word clusters and word embeddings, we train a fast and simple linear classifier


Abstract In this article, the risk and return characteristics of Treasury Inflation Protected Securities (TIPS) are empirically examined and compared to those of a series of investments in Treasury Bills. Using secondary market prices for the period January 1997 to May 2001 on TIPS issued in the United States, we show that TIPS offer a marginally higher average return but a much higher volatility of returns than a series of Treasury Bills, for various investment horizons. We argue that the observed risk/return qualities are introduced by the variability of real rates and the taxation of inflation adjustments made to TIPS. © 2002 Academy of Financial Services. All rights reserved. 1. Introduction Recently, we have seen the advent of inflation-protected investments. Since 1997, the U.S. Treasury has issued five-year, ten-year, and thirty-year notes and bonds indexed to the Consumer Price Index (CPI-U). These are collectively known as Treasury Inflation Protection securities or TIPS. Also, since September 1, 1998, other indexed securities have been issued by governmental agencies such as the Tennessee Valley Authority and the Federal Home Loan Bank System. In addition, at least four mutual funds have been created to invest solely in these securities. In this article we examine the realized return and volatility of returns of TIPS for the period January 1997 to May 2001. Our results provide financial planners a clear idea of TIPS characteristics and their suitability for inclusion in an investment portfolio. In spite of this recent activity, market acceptance of TIPS has been limited. TIPS represent only about three percentage of the total Treasury marketable debt (Dupont and Sack, 1999). Also, secondary market trading has been very limited (Lucas and Queck, 1998). One possible reason for the lackluster performance is today's relatively low inflation rate and the reduced need for inflation protection. The market may be further limited because of the Treasury's decision to tax inflation adjustments as current income. Because the inflation adjustments made to TIPS are taxed as current income and because the adjustments rise in periods of inflation, taxes paid can exceed the cash coupon in any period. Thus, investors can end up making net payments to the Treasury merely to preserve the inflation-adjusted principal. Depending upon the inflation rate, the after-tax cash flow on TIPS can be either positive, zero, or negative. At best, under moderate inflationary conditions, the after-tax cash flow declines as inflation rises. This is clearly not the intended outcome for those seeking inflation protection. TIPS deliver this protection only for investors not subject to income taxation. Beyond their failure to deliver inflation protection to taxable investors, TIPS also have the following negative qualities for taxable investors: * Because both real and nominal returns on TIPS vary with future rates of inflation, taxable investors are unable to lock in either a nominal or a real yield on TIPS. * For taxable investors, net after-tax coupons/cash flows can become negative. This would not occur when taxable investors buy traditional securities nor when tax-exempt investors purchase TIPS. If positive cash flows are deferred until TIPS mature, they carry an embedded market risk. Theoretical TIPS returns in the absence of taxes are similar to those of a series of investments in Treasury Bills plus an adjustment for possible changes in real rates. Given the tax consequences and the risks from an investment in TIPS, they would appeal to a taxable investor only if the holding period return is significantly higher than a series of investments in one-month Treasury Bills. We empirically show that returns on TIPS are marginally higher than corresponding investments in Treasury Bills for the similar investment horizons. However, TIPS returns are much more volatile than Treasury Bill returns. …


We find conditions for which a manifold endowed with an integrable almost transversal structure is the total space of a vector bundle isomorphic to the transversal bundle of a foliation.


The roll-out of smart meters in electricity networks introduces risks for consumer privacy due to increased measurement frequency and granularity. Through various non-intrusive load monitoring techniques, consumer behavior may be inferred from their metering data. In this paper, we propose an energy management method that reduces energy cost and protects privacy through the minimization of information leakage. The method is based on a model predictive controller that utilizes energy storage and local generation, and that predicts the effects of its actions on the statistics of the actual energy consumption of a consumer and that seen by the grid. Computationally, the method requires solving a mixed-integer quadratic program of manageable size whenever new meter readings are available. We simulate the controller on generated residential load profiles with different prices of privacy loss in a two-tier time-of-use energy pricing environment. Results show that information leakage is effectively reduced at the expense of increased energy cost. The results also show that with the proposed controller the consumer load profile seen by the grid resembles a mixture between that obtained with non-intrusive load leveling and lazy stepping.


In this paper, we consider single relay cooperative communication system in wireless network. We focus on symbol error rate (SER) performance analysis and optimum power allocation for an amplify-and-forward(AF) protocol. And we also present AF protocol.


We generalize the positivity conjecture of (Kauffman bracket) skein algebras to Roger--Yang skein algebras. To generalize it, we use explicit polynomials like Chebyshev polynomials of the first kind to give candidates of positive bases. Moreover, the polynomials form a lower bound in the sense of [L\^e18] and [LTY21]. We also discuss a relation between the polynomials and the centers of Roger--Yang skein algebras when the quantum parameter is a complex root of unity.


The application of digital pixel hologram (DPH) as anti-counterfeiting technology to consumer products is growing important nowadays. Recently, a very high-resolution DPH has been fabricated successful using the electron beam lithography (EBL) facilities housed in Optoelectronics Research Center, City University of Hong Kong. In this paper, we propose an optical encryption technique, called Optical Transform Coding (OTC), which can be used to further enhance the anti-counterfeiting performance of DPH. Details in coding and decoding processes are described. Two DPHs of resolution 2540 dpi are fabricated to demonstrate the technique using a City University (CityU) and Hong Kong Special Administrative Region (HKSAR) logos as examples.


Introduction: Hypersensitivity is a short, sharp pain that can occur due to the response of the exposed dentin to touch and chemical stimuli. The best solution for hypersensitivity treatment is closing the dentin tubules by crystal deposition in tubule openings or melting the dentin hydroxyapatite. The present study aimed to investigate the effect of dentin desensitizers on the shear bond strength of dentin glass restorers. Materials and methods: In the present study, 60 healthy human premolar teeth were selected. The teeth surfaces were sheared 2 mm under the DEJ. The samples were divided into three groups of 20 each. Group 1: pure dentin, group 2: low-power laser diode with the intensity of 3.7 j/cm2, period of 5 min, and length of 0.66 µm on the dentin surface. Group 3: the CPP-ACP paste on occlusal dentin. Each group was divided into two subgroups of 10. The first subgroup was filled with Fuji II LC glass on the center of dentin's surface in plastic mold and the second with Ketac N100 nano-ionomer. Thereafter, the shear test of samples was performed and the shear bond strength was measured using ANOVA and Tukey tests. Results: In Fuji II LC groups, no significant difference was observed between the mean of shear bond strength in three groups of laser, control, and CP-CPP ( P =0.086). However, in Ketac N100 group, the mean of shear bond strength of the laser-treated group was significantly higher than two subgroups of control and CPP-ACP (P laser =0.035, P control =0.027). Conclusion : Based on the findings of the present study, in CPP-ACP and Control groups, Fuji II LC glass ionomer had better results than Ketac N100. However, no significant difference was observed between the laser-treated groups using different glass ionomers.


. Light-gas (hydrogen or helium) guns have been in use for accelerating small projectiles or test specimens to hypervelocities. The approximate practical performance limit of (two-stage) light-gas guns in common use has been 30,000 feet per second. To simulate the effects of micrometeoroid interaction with spacecraft structures, it is essential to accelerate projectiles (particles) weighing from 12 to 105 gram to velocities up to 50,000 feet per second. As the light-gas gun provides an intact, discrete projectile of known mass, material, and geometry required for studying the micrometeoroid impact process in detail, a theoretical and experimental investigation was conducted to extend the capability of a conventional light-gas gun at a NASA facility. One of the principal results of the investigation has been the development of a disposable accelerator on the muzzle of the light-gas gun. The accelerator operates on gas dynamic principles. It uses the energy and momentum of a primary projectile, launched by the light-gas gun, to achieve high velocities of a relatively light secondary projectile accelerated from rest in the accelerator. The internal cross sectional area of the accelerator is constant and identical to that of the light-gas gun barrel. The design principle of the constant-area accelerator is shown in the schematic diagram. Initially, the column of gas in the compression tube is at rest. A high-velocity primary projectile from the gas gun fractures the diaphragm and enters the compression tube where it loses energy to the gas, causing it to accelerate. Increased gas pressures force the low-mass secondary projectile to accelerate down the launch tube. This exchange of energy and momentum continues up to the point where there is no significant decrease in the velocity of the primary projectile or increase in the velocity of the secondary projectile. The theoretical investigation indicated that secondary velocities which were 60 to 80 percent higher than the primary velocity could be achieved for primary-to-secondary projectile mass ratios of 20 or greater. Such increases were found to be independent of primary velocity, if losses are neglected. Experimental firings gave good agreement with theory. Secondary velocities were 45 to 60 percent higher than primary velocities for a projectile mass ratio of 18. There was little tendency for the percentage increases to fall off with increasing primary velocity, indicating that energy-loss effects were not severely limiting the accelerator performance.


Objective To investigate the impact of Huoxuetongmai decoction on the expression of Fas,Caspase-3 induced by cerebral ischemia reperfusion injury in rats.Methods 80 rats were randomly divided into four groups:sham operated group(n=20),model group(n=20),aspirin group(n=20),Huoxuetongmai decoction group(n=20).24h after ischemia reperfusion,rats were executed.The area of cerebral infarction and the pathological change in ischemia area were observed by HE staining.The expression levels of Fas,Caspase-3 were measured by immunohistochemistry.Results In comparison with sham operated group,the area of cerebral infarction obviously increased,the expression of Fas and Caspase-3 in brain tissue obviously increased at 12h and 24h after reperfusion in model group(P0.01).In comparison with model group,the area of cerebral infarction obviously reduced and the expression of Fas,Caspase-3 significantly decreased in Huoxuetongmai decoction group(P0.01,P0.05).There was no difference between Huoxuetongmai decoction group and aspirin group(P0.05).Conclusion Huoxuetongmai decoction could inhibit excessive expression of Fas and Caspase-3,thereby relieve cerebral ischemia reperfusion injury.


A shared password authentication scheme is analyzed, and its security weak points and some limitations on its security are pointed. Using the techniques of verifiable secret sharing a shared password authentication scheme based on discrete logarithms is proposed, which has a novel property that the previous shared password authentication scheme do not have, that is, to prevent the PGC, user or authenticator from cheating.


The role of green public space in our urban environment isas an important provider of ecological functions such as preventing flood, reducing air pollution, and reducing the temperature of the air. The Government of Semarang city publish the local regulation of Semarang number 7 in 2010 about a regulation of arrengement of green space as one effort to resolve arrengement green open sapce in Semarang. There is still a lack of green open space in Kecamatan Candisari which is the background of this research. The research is aimed to evaluate impact the local regulation of Semarang number 7 in 2010 about a regulation of arrengement of green space in district Candisari, Semarang. The implementer in this policy is the Bappeda, Department of Spatial Planning, Department of Housing and Settlements, and Department of Enviroment of Semarang City. The research uses the principal of policy implementation according to Riant Nugroho like, right policy, proper executor, right target, right environment, and proper process and impact evaluation according to Samudra Wibawa of authority like, individual impact, organization and group impact, society impact and social impact culture. The research method is qualitative and the data collection techniques are interviews, observation, and documentation. The results of the local regulation of Semarang number 7 in 2010 about a regulation of arrengement of green space in Candisari district is not maximum with the goals. This is due to the lack of green open space and lack of public participation in increasing green open space on social life in Candisari District.


The authors continue their investigations into types of heterokaryons in an effort to detect an inhibition of nondividing macrophages (differentiated cells) on the entry of the nuclei of proliferating cells into replication. For the experiments described in this paper, the authors used asynchronous cultures of mouse diploid fibroblasts (MDF), 3T3 mouse cells from continuous culture, and malignant SV3T3 cells (3T3 cells transformed by SV40). Fusion of the cells of the cultures with macrophages was performed using PEG at various periods after deposition (2, 8, 12, and 20 h). The authors used double isotope marking to identify DNA synthesis in the heterokaryons. For this purpose, the nuclei of the culture cells were labeled with (/sup 3/H)thymidine before fusion with macrophages. All the nuclei of the culture cells intensively incorporated the label. After fusion, (/sup 14/C)thymidine was introduced into the incubation medium. If the cell nucleus began to synthesize DNA, it incorporated (/sup 14/C)thymidine, and a supplementary relatively weak label appeared on the auto-radiographic preparations, both above the nuclei themselves and next to them. The nuclei of macrophages in which DNA synthesis was reactivated contained only the (/sup 14/C)label. Fixation was performed 26 h after stimulation (in the case of 3T3) ormore » 35 h after stimulation (for MDF). The percentages of nuclei of culture cells labeled with (/sup 14/C)thymidine were determined in the heterokaryons and free-lying cells.« less


The research explores an aspect of teacher-learner and learner-learner interaction in Iranian EFL classroom discourse. Based on the assumption that classroom interaction is inherently a dialogue among teacher and learners, this study looks in detail at key aspects of the ways in which Iranian EFL teachers and learners interact with each other, bring their interactants into the context, and involve them in the construction of the discourse and the arguments in order to contribute to the interactiveness and persuasiveness of the oral discussion in the classroom. To do so, Interpersonal Metadiscourse Resources – Stance and Engagement– are looked at in a corpus totally 14,249 words produced orally by Iranian EFL teachers and female learners at advanced proficiency level in 15 sessions. The oral discussions were transcribed and analyzed using frequency frameworks and formulas. The results reveal that the teachers and learners use stance and engagement markers one about every four words and that both use the devices for fairly similar purposes. The findings, however, show noticeable quantitative differences: the teacher use Interpersonal Metadiscourse Resources more frequently than the learners. The teachers, also, use engagement markers considerably more frequently than stance markers; whereas EFL learners use both use stance markers and engagement markers almost equally. The quantitative differences seem to be related to the teachers' expertise in English language as well as the teachers' awareness of metadiscourse. The pedagogical implications of the study for novice EFL teachers, learners and material developers are outlined.


This book would serve as an ideal guide for B.E.. B.Tech., B.S., B.Sc, B.C.A., undergraduate students of Computer Science and Engineering, Information Technology, Electronics and Communication Engineering who wish to take up projects on Internet of Things and its Applications. Students pursuing postgraduate course in Science and Engineering, M.E., M.Tech., M.S., M.Sc., M.C.A. students will find this book useful for their projects. Research Scholars working in the area of Fog computing and Internet of Things will find this book as a handy reference guide for their M.Phil., Ph.D. D.Sc., and other post-doctoral research works. Software and Hardware Engineers involved in IT and ITES sector specifically on Internet of Things and its Application domain, would find this book as a useful resource. This book covers a spectrum of Applications of Internet of Everything in various domains and disciplines. As a word of conclusion I believe that the reader will find this book as a really helpful guide and a valuable source of information about Internet of Everything and its Applications.


In this paper we are concerned with the simulation of stationary dynamic economies that go beyond the convex representative agent framework. We allow for noncontinuous Markovian laws of motion that may occur in models with discrete choices, multiple equilibria, bargaining power, optimal monetary and fiscal policies, heterogeneous agents, and market distortions. We prove the existence of an invariant distribution for the equilibrium correspondence, and establish some convergence and accuracy properties for the simulated moments. We obtain these results without imposing arbitrary convexity assumptions on the equilibrium correspondence.


In recent years the tourism industry has attracted increasing attention, particularly in relation to its employment generating potential and its impact on the balance of payments (see for example English Tourist Board (1987)). The industry is now seen, at least by policy makers, as a major growth industry (see for example Department of Employment (1986)).


Abstract : Meteorological data gathered for the launching of the 19321 at MLRS, Missile Number 421, 379, 464, 377, 401, 367, Round Number V635/FE-7 thru V640/FE-12 are presented in tabular form.


(57) Abstract: Nicotine methods and solutions that utilize an acid solution containing nicotine. The solution to reduce the desire for smoking users who smoke, in order to alleviate the symptoms of attention deficit disorders in humans, and / or such as for reducing the symptoms of Alzheimer's disease in humans, a variety of medical it is intended to be used to treat conditions. The solution preferences to be satisfied may be introduced into the human by human drink it. After drinking, plasma levels, to reduce the desire for smoking, to reduce the symptoms of attention deficit disorder, and / or is sufficient to alleviate the symptoms of Alzheimer's disease.


Cryogenic scanning tunneling microscopy has been used to measure the structure and the local electronic density of states of thin gold islands in metallic contact with a bulk superconducting NbSe 2 crystal. Peaks are observed in the tunneling conductance below the energy gap corresponding to discrete bound quasiparticle states in the gold. The energies and spatial dependence of the bound states imply that the superconducting pair potential falls off abruptly at the Au-NbSe 2 interface


DURING THE LAST TWO YEARS there has been an encouraging uplift in the introduction of new drug products in the United States. In fact, for newly synthesized drugs the figures are the highest since 1967. (A ten-year comparison is given in Table 2 and Figures 1 and 2 on the subsequent pages.) Of the 19 newly synthesized drugs or new chemical entities introduced in 1973 thirteen originated with American research establishments. Of the 18 drugs introduced in 1974 twelve and one-half had their origin in this country and five and one-half came from foreign lands. Three of the U.S. developed drugs were first marketed abroad before


The pressing demands of improving energy efficiency for high performance scientific computing have motivated a large body of software-controlled hardware solutions that strategically switch hardware components to a low-power state, when the peak performance of the components is not necessary. Although OS level solutions can effectively save energy in a black-box fashion, for applications with random/variable execution patterns, slack prediction can be error-prone and thus the optimal energy efficiency can be blundered away. We propose to utilize algorithmic characteristics to predict slack accurately and thus maximize potential energy savings. Keywords-energy; critical path; algorithmic slack prediction.


Thermal interface materials (TIMs) which consist of metal foil and soft cushion are used in the process of chip processor platform validation (PPV) process, and some defects, such as the stains caused by debris peeled off from TIMs due to stress concentration, were found on the surface of the chips and they had an hazardous influence in the testing process. As well as that, the thermal resistance of TIMs is also a crucial issue that deserves to be further studied. To solve these problems, not only the metal layers in TIMs with less contamination are needed to be chosen, but also TIMs with higher thermal conductivity are needed to be developed. In this paper, Finite element method (FEM) was employed to evaluate the stress concentration area, where the debris were normally observed. And different kinds of composite were fabricated in a mould and tested in the PPV detection system. Simulation results showed that the stress concentration area is located at the contacted position between Al foil and chip, where the maximum stress and strain is 3.03×107Pa and 9.379×10-3 respectively. In addition, four different kinds of TIMs were fabricated and tested in the PPV system. It was found that the copper/ soft cushion is the potential TIMs.


Abstract : The purpose of this study was to investigate the shopping condition of Dongdaemoon Shoppingmall. A depth interview was administered to eight consumers aged 10s through 30s who had shopping experiences at Dongdaemoon Shoppingmall. The contents of interview were about the reasons of preference for Dongdaemoon Shoppingmall, the mer-chandise categories purchased, assortment, price, shopping environment, and service offered by Dongdaemoon Shop-pingmall. The results of this study were as follows: The reasons of consumers' Dongdaemoon Shoppingmall preference were reasonable price, variety of merchandise assortment, easy catch of fashion trend, entertainment place, and opening hour at nighttime. The mainly purchased items were casual and fashionable clothes. Children's wear was mainly bought item by housewives too. The unique design, similar merchandises sold at department stores and new style in early adop-tion of fashion cycle were perceived as positive aspects, but copied merchandises and large quantity of same merchandise as negative aspects. The fixed price system was not trusted by consumers. Consumers' complaints about shopping con-dition were crowded pathways and shopping booths, the lacks of facilities such as fitting room, toilet, lounge area, sales persons' service, and difficulty of using credit cards. From these results, some implications for marketing strategies and practices might be suggested. In order to improve the design variety of merchandises, marketers and apparel man-ufacturers should make efforts by managing merchandise planning, production, selling, and promotion cooperatively. Fixed price system, acceptance of credit cards, and merchandise return/exchange service should be improved. The training the salespersons was the most important and basic step and easy way to get to successful business. Key words : Dongdaemoon Shoppingmall, shopping condition


Objective To investigate the protective effect of magnesium isoglycyrrhizina(MgIG)on hepatic injury induced by 70% partial hepatectomy in mice.Methods Mter suffered from 70% partial hepatectomy,the mice were divided into control group[treated with saline 10 ml/(kg · d) ],MgIG low dose group [30 mg/(kg · d)],MgIG middle dose group [50 mg/(kg · d)] and MgIG high dose group [ 70 mg/( kg · d) ].There were 25 mice in each group.On 1,2,3,5 and 7 days after 70% partial hepatectomy,serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in each group were measured to assess liver function.Meanwhile,liver weight and body weight were measured and the ratio of liver weight to 100 g body weight was caculated to assess the hepatic regenerative activity.Histological changes in livers of each group were observed by hematoxylin and eosin (HE) staining.Results Compared with saline-treated control group,magnesium isoglycyrrhizina significantly decreased the serum ALT and AST activities on 1st,2nd and 3rd day after hepatectomy( P <0.05 ),significantly increased liver weight/100 g body weight ratio on 2nd and 3rd day after hepatectomy ( P < 0.05).Conclusions Magnesium isoglyeyrrhizina can keep hepatocytes intact and enhance hepatic regenerative activity in mice after 70% partial hepatectomy.

Key words:
Magnesium isoglycyrrhizina;  Partial hepatectomy ;  Liver regeneration ;  Hepatic injury


Rough set theory was introduced into the demand forecasting of agricultural machinery. After extracting key factors from all influencing factors, significances of key factors were ranked and forecasting rules with conformity and completeness were obtained. Comparing with other traditional forecasting methods, our method is widely applied, which doesn't need precondition and can effectively deal with the coupling and nonlinear relation between the demand of agriculture machinery and influencing factors.


The polymerization reaction was processed based on a specific proportion of MA,AM and MMA that were the monomers,and ammonium persulfate as the initiator in aqueous phase,through which MA / AM / MAA ternary non- phosphorus copolymer scale inhibitor was prepared. It was demonstrated by infrared analysis that all the products gained were termolymers. It was found out by static scale inhibition experiment on calcium sulphate that the rise of temperature could have a slight drop to scale inhibition rate when the concentration of polymer was 6 mg / L,and the scale inhibition rate was over 90%,and the dispersion performance of Fe( Ⅲ) was better.


Introduction: Ventilator associated pneumonia (VAP) is the most frequent infection in patients under mechanical ventilation. The percentages vary from 40% to 87%. Mortality is various and depends on the microbe species the time the symptoms start and the time the treatment starts. Purpose: The purpose of this study was to explore knowledge of Nurses in VAP prevention methods. Methods: Data was collected by the completion of specially designed questionnaire for the needs of Greek hospitals which included two parts. The first part included the demographic variables while the second part included questions relevant to VAP preventions ways. All reported p values were compared to a significance level of 5%. Statistical analysis was conducted by Mann-Whitney test, Kruskal-Willis, Spearman and Kolmogorov - Smirnov test. Results: From the 122 participants nurses, the 98,7% of them consider as essential the education of health professionals in regard to Hospital Infections. 97.5% of the participants reported the changing of gloves for different number of interventions as the main prevention measure. The 79,5% of the sample reported that the combination of hand washing, isolation of the patient and reduction of mechanical ventilation time were the most significant prevention factors. Conclusions: Health professionals play a crucial role in VAP prevention and control.


Received: 14-10-2021 Revised: 20-11-2021 Approved: 22-11-2021 Publish Online: 31-12-2021 Abstract: This research aims to knowing the improvement of understanding mathematical concepts ability using a personalized system of instruction model and knowing students' understanding of mathematical concepts using a personalized system of instruction model is better than understanding students' mathematical concepts using ordinary learning. The research design used is an experimental type of quantitative research and uses a pre-test post-test control group design. The population in this study were grade VIII students of SMP Negeri 07 Kerinci for the 2020-2021. The samples is taken by cluster random sampling technique. The research instrument used of a concept understanding test in the form of a description. The data analysis technique used paired t test and two sample t test. Based on the result of data analysis, it was an increase in the ability to understand students's mathematical concepts by using a personalized system of instruction model and understanding students' mathematical concepts by using a personalized system of instruction model is better than understanding students' mathematical concepts using ordinary learning models.


We report Monte Carlo simulations of a lattice-polymer model that can account for both polymer crystallization and liquid–liquid demixing in solutions of semiflexible homopolymers. In our model, neighboring polymer segments can have isotropic interactions that affect demixing, and anisotropic interactions that are responsible for freezing. However, our simulations show that the isotropic interactions also have a noticeable effect on the freezing curve, as do the anisotropic interactions on demixing. As the relative strength of the isotropic interactions is reduced, the liquid–liquid demixing transition disappears below the freezing curve. A simple extended Flory–Huggins theory accounts quite well for the phase behavior observed in the simulations.


This article examines the reactions of the churches to the Suez crisis, focusing in particular on the leadership of the Church of England. It argues that the fact of religious establishment required a response from the Archbishop of Canterbury who proved a surprisingly robust critic of the military intervention, albeit at the cost of alienating many in the pews. Whilst making use of his access to political elites, he nonetheless remained keen to work with other church leaders in developing a shared critique based on the rejection of the use of force and Britain's right to be judge in its own case, instead stressing the need for an international resolution of the crisis. Yet, as the crisis developed, it became apparent that church leaders were not always able to speak for church members, who were as bitterly divided as the rest of society over both the specific issue and the wider argument on how best to respond to Britain's declining role in the world. This in turn presaged future debates, as increasingly specialist church agencies and religious leaders found themselves taking positions on social and political affairs that were often at odds with those of many within their own constituencies.


This research in this paper majors in identifying information needs, specifying measures and analysis model of indicator.First put forward the goal-drive software test measurement method named GSTM.Basing the GSTM classed the test measurement information needs into six classes.Basing on the information needs put forward methods to design the base measurement,derived measurement and indicator.


We present a qualitative discussion of the nature and nonradiative decay of electronically excited states at metal surfaces. Within an Anderson–Newns type of Hamiltonian, we calculate, using the memory function formalism, the effect of the substrate on the energy and shape of the optical absorption or electron energy loss spectra and present illustrative numerical results. The theory is compared with experimental data for excited noble gas atoms on noble metal surfaces.


Objectives: To study the expressions of transforming growth factor-β1 (TGF-β1) and type-1 TGF-β receptor (TβR-I), and their relationships to clinicopathological characteristics in cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC). Methods: The expression of TGF-β1 and TβR-I was determined by ABC immunohistochemical technique in 48 cutaneous SCCs and 41 BCCs. Results: The expression of TGF-β1 and TβR-1in SCCs was significantly higher than that in BCCs (P 0.05). TβR-1 expression in well differentiated SCCs was upregulated compared with the poorly differentiated one (P 0.05), but TGF-β1 expression was not related to the histological grade (P 0.05). Although significantly positive correlation was observed between the expression of TGF-β1 and TβR-I in SCCs (r=0.739,P 0.001) and in BCCs (r=0.716,P 0.001), their expression was not correlated with sex, age, course of diseases, tumor location, primary or metastasic tumors, lymph node metastasis and aggressiveness of BCC (P 0.05) in SCCs and BCCs. Conclusions: The expression of TGF-β1 may not be related to tumor differentiation, aggressiveness and lymph node metastasis.


An enterprise-grade SSD with TLC (3b/cell) NAND Flash is presented with three techniques that achieve high speed and high reliability. Quick low-density parity-check (LDPC) reduces the read latency of 1Xnm TLC NAND Flash SSD by 83%. Dynamic VTH optimization and auto data recovery reduce the NAND Flash bit-error rate (BER) by 80% and 18%, respectively. These techniques can be implemented in the SSD controller without circuit overhead. No modification is required to the TLC NAND flash.


The goal of this research is an assessment of the possible use of peatlands
 biomass and straw for the production of mixed bio-pellets. Peaty soils are a
 specific type of soils formed as the result of wetlands drainage. Peat
 mining is completed by the factory if the layer of the peat is less than 1-2
 meters and not enough deep for effective mechanical excavation. After the
 peat excavation is finished, the biggest problem is the use of these lands
 for other purposes. One of the perspective directions is rewetting of
 post-mining peatlands to stimulate the growth of common reed, cattail,
 fescue, sedge, and other grasses which may grow in natural conditions, and
 also improve conditions for the cultivation of other plants, including
 trees. The yield of wetland grass in Belarus varies from 8.1 to 14 DM g ha-1
 per year. The yield of willow wood can reach 8-10 of DM g ha-1 per year. The
 highest prime cost of biomass is obtained for willow wood, but it will be
 lower with the enlargement of the plantation area. Pellets with a high
 content of wood residues (sawdust) have the best technological parameters
 including calorific value when compared to pellets from only peat and peat
 plus straw. Biomass production on degraded peaty soils has also an
 ecological effect. The cost of carbon quotas on the market varies from 20 to
 25 euro per ton, and biomass production can provide additional profit in the
 case of CO2 emissions trading depending on the biomass content in the fuel.


Bidders in procurement auctions often face avoidable fixed costs. This can make bidding decisions complex and risky, and market outcomes volatile. If bidders deviate from risk neutral best responses, either due to faulty optimization or risk attitudes, then equilibrium predictions can perform poorly. In this paper, we confront laboratory bidders with three auction formats that make bidding difficult and risky in different ways. We find that measures of `difficulty' provide a consistent explanation of deviations from best response bidding across the three formats. In contrast, risk and loss preferences cannot explain behavior across all three formats.


In connection with a current investigation of the Mesozoic rock sequence in central Bolivia, Dr. Aniello Russo of the Yacimientos Petroliferos Fiscales Bolivianos collected vertebrate remains at various localities in a unit recently designated as the El Molino Formation. These remains, which include several kinds of fishes and a turtle, were sent to me for identification and possible age determination by Prof. Leonardo Branisa of the Departamento Nacional de Geologia. I am indebted to Professor Branisa for presenting this collection to the American Museum and for furnishing data on the stratigraphic occurrence. Dr. H. J. Harrington of the Tennessee Overseas Company has generously provided a critical summary of the pertinent stratigraphy. Mr. Charles C. Smith of Houston, Texas, and Dr. Nicholas Hotton of the United States National Museum, Smithsonian Institution, have kindly lent specimens of Onchopristis dunklei, and Drs. C. L. McNulty, Jr., and B. H. Slaughter have permitted me to examine their manuscript on this species. Dr. Ricbard Estes has furnished information on the Rhombodus-Myledaphus complex. Dr. J. A. F. Garrick and Dr. D. H. Davies have supplied helpful data on the habits and distribution of the sawfish and sawshark. Dr. M. L. Moss has aided in the interpretation of pristid rostral tooth histology. The drawings were made by Mr. Michael Insinna, and the photographs were taken by Mr. Chester Tarka.


The axial organ is considered as ancestral lymphoïd organ. It contains T and B sea star lymphocytes and Phagocytes. It plays a fundamental rôle in the sea star cell-mediated immune responses and humoral immune ones.Asterids belong to Echinoderma (Invertebrates).An expected rôle of Tiedemann's bodies is evoked.


The invention relates to a system for showing the origin of a certain amount of electrical energy generated by a first method, which is transported via a network which is also adapted to transport energy generated by a second method, wherein the system comprises: at least one device for producing certificates which represent a quantity of energy generated by a first method; a system for transferring the thus produced certificates to consumers from the network; at least one measuring and interrupting device for connecting between the network and a user of electrical energy for proportionally reducing the energy representing the certificate in accordance with the electrical energy flowing through the device and for transmitting electrical energy when the certificate represents energy generated by the first method.


Abstract Investigation of glass transition temperature and viscosity of binary mixtures of poly(methyl metacrylate) with statistic copolymers of methyl metacrylate and ethyl, butyl or octyl metacrylates as well as mixtures of poly(methyl metacrylate) with poly(ethyl, poly(butyl or poly(octyl metacrylates) has been carried out. The regions of one-and two-phase states of the above-mentioned mixtures were found from the glass transition temperature date. It has been shown that the mixtures of poly(methyl metacrylate) with copolymers of methyl metacrylate in combination with ethyl metacrylate are capable of forming one-phase systems throughout the whole range of the mixture compositions when extensively varying the copolymers compositions. The transition to copolymers of methyl metacrylate involving butyl and especially octyl metacrylates leads to a sharp narrowing of the range of the composition of their mixtures with poly(methyl metacrylate) in which they form one-phase-systems. We have established dependen...


While emerging economies present business opportunities for global organizations, the differences and challenges in extending the existing business processes to the emerging economies are significant. These differences come from new strategies adopted for emerging economies, by the firm, the business environment of the host country and the existence of institutional voids. It is critical to examine the how business processes can be modelled to handle these requirements. A specific business process designed for the same objectives can turn out to be very different in a developed and an emerging economy. These differences are even more pronounced for the service industries. In this paper, we discuss the several characteristics of emerging economies which can influence the process design, architecture and infrastructure. We use the example of a citizen service, viz. 'passport issue process in India' to illustrate the differences. The element of manual work involved in this example helps to highlight many aspects which may not be so apparent if a completely IT-enabled industry were chosen. Here the e-government services help identify the issues of modelling services process and the challenges of an emerging economy.


The thermo-mechanical and electrical properties of conductive epoxy composites are studied and the large decrease of the conductivity as a function of the temperature is analysed in terms of Positive Temperature Coefficient (PTC) effect. Three classes of fillers are used for the materials preparation consisting of polypyrrole (Ppy), carbon black and metallic fillers. The PTC mechanism was found to be dependent on the conducting filler, and a new approach was proposed leading to a better understanding of this phenomenon in amorphous filled polymers. The electrical non-linear properties of organic conducting composites as epoxy/Ppy have received a particular attention.


A very simple mathematical sequence is detected in a half-century of thermal radio flux from the Sun. Since the only known solar source for the sequence is global oscillations trapped in the nonconvecting interior, g-modes and probably r-modes are active. If so, their rotation frequencies are detected and some previously reported difference frequencies are confirmed with high confidence. All angular harmonics for 2 ≤ ℓ ≤ 7 are detected as well as some others up to the limit ℓ ≤ 14 resolvable by the observations (a Fourier spectrum of the 10.7 cm flux time series). The mean sidereal rotation rate of the nonconvecting interior is 428.2 nHz as averaged by g-modes and 429.8 nHz by the r-modes, indicating that g-mode energy is a bit more centrally concentrated. Helioseismology measures such rotation rates near 0.36R (R = solar radius), so the global modes would have about half their kinetic energy above and below that level. This, and the known log (r) energy dependence of most modes, implies that these oscillations are significantly reflected near 0.18R, the same level at which sound speed measurements display a maximum departure from theoretical models.


The information service based on literature more and more cannot satisfy the university teaching and the scientific research to the information service request.The university readers more and more favor subject information service based on knowledge.we can summarize the service process of the subject information service:First analyzing macroscopic and the microscopic information environment;second choosing the core service content;finally constructing highly effective information service mechanism.


cess of this Upton-led approach to the complex field of radiation risk, which encompasses a broad range of physical and biological processes, has served as a model for weight-of-evidence approaches across the whole field of risk analysis. It is a model that Dr Upton him-self has successfully replicated in such diverse fields as asbestos for the Health Effects Institute; and the peer review process of the Consortium for Risk Evaluation with Stakeholder Participation. Success in these efforts reflects not only on Dr Upton's scientific leadership skills, but also on the deep respect of the scientific com- munity for his fairness.


Introduction Our research sought to assess the psychological and social wellbeing of paramedics in Riyadh City in Saudi Arabia during the COVID 19 pandemic. It also aimed to assess the therapeutic assistance provided to pre-hospital care givers during the pandemic. Methods In this quantitative cross-sectional analysis an assessment of 106 paramedics was undertaken from data obtained from 28 September to 10 November 2020. The authenticity and durability of Pilot and the Cronbach have been added. Results Of the 106 paramedics surveyed, 60 (56.6%) were 30–39 years of age; 101 were male (95.3%). The mean average psychological wellbeing of the paramedics was 6.41 with the standard deviation of 2.42. Family and friends' average social support score was 9.2 in norm 2.6 deviation. Conclusion Our study showed that during the COVID-19 pandemic paramedics suffered from social and psychological depression. Paramedics must be protected from the socioeconomic and psychological difficulties they face every day in order to combat the COVID-19 pandemic.


FIELD: medicine. SUBSTANCE: group of inventions relates to medicine and can be used to treat a patient with a malignant tumour associated with a WEE1 kinase. To this end, the patient undergoes measurement of the expression level of the PKMYT1 gene in a biological sample containing malignant cells obtained from said patient and in a control sample. Further, it is determined whether expression level of the PKMYT1 gene in said sample from the patient is higher or lower than the expression level in said control sample. Said patient is then selected for treatment with a WEE1 inhibitor if the PKMYT1 level from the patient's sample is lower than in the control sample. And the patient selected for treatment of a malignant tumour is injected with a WEE1 inhibitor. Also disclosed is a method for treating a patient with a malignant tumour associated with a WEE1 kinase, where the patients are characterised by low expression levels of PKMYT1. EFFECT: group of inventions provides treatment of a malignant tumour in patients with low expression levels of PKMYT1. 13 cl, 20 dwg, 9 ex


The objective of this paper is to understand the impact of intellectual capital on firm's stock return. The increasing importance of intellectual capital that generates more value is beneficial both for managers and investors at large. The banking sector in Indonesia is chosen as the data sample for this research. Intellectual capital is measured by VAIC TM , a method developed by Prof. Dr. Ante Pulic. This method allows the quantification of intellectual capital and the categorization of its elements into 'human capital efficiency', 'structural capital efficiency' and 'capital employed efficiency', which also enables to get more insight of their effects. The regression models explore the relationship between current and future stock returns and intellectual capital and its constituents. The findings show that intellectual capital does not affect the current stock return, but it however contributes to stock return growth. Only one element of intellectual capital affects the stock return. The results may indicate that changes of stock returns are mostly determined by external factors such as inflation, exchange rate and socio-economic conditions. This paper focuses on the nature of the Indonesia stock market which prefers short term profit gained by a company rather than long term sustainable growth which indeed undermines intellectual capital.


Scholars have long recognized the importance of interethnic marriage to European commercial expansion into the Americas, Africa, and Asia. George Brooks Jr. has chronicled the evolution of French-Senegalese marriages in eighteenth-century West Africa under the rubric of "Signareship" to demonstrate how ambitious Wolof and Lebou women "provided [European merchants] access to African commercial networks . . . and proved indispensable as interpreters of African languages and cultures" (1976, 40). Theda Perdue has analyzed a similar pattern of opportunistic intermarriage between British merchants and daughters of Choctaw, Cherokee, Chickasaw, and Creek chiefs in eighteenth-century North America (2003, 9–24). For late nineteenthcentury northern Sumatra, Ann Stoler writes of "an extensive system of concubinage"


In the past decade or so there has been a well-documented decline in language take-up among secondary school pupils of Years 10 and 11 in England (14–16-year-olds, also referred to as Key Stage 4 in the national curriculum for England and Wales) and there have been fewer UK-domiciled undergraduates or postgraduates studying for a languages degree (a decrease of 5.7% and 2.3%, respectively in the academic year 2005–06 by comparison with 2002–03 (CILT 2009). However, having tracked trends in language learning for over a decade and in the light of our various research initiatives, at CILT, the National Centre for Languages, we believe that there are reasons for restrained optimism about the future of the UK's national capability in languages.


Transferrin is a glycoprotein and migrates with beta globulin in the electrophoresis. Since Smithies [l] discovered transferrin variants, there have been many investigations about them and at the moment 21 variants are known, each one with different electrophoretic mobility. They are are Tf C (usual form), Tf B (fast variants) and Tf D (slow variants), with the subscript indicating the migration degree in groups B and D. Their geographical distribution is universal, but with a very low frequency of the groups B and D [2]. In a wide bibliographical study, we found only three papers about transferrin variants in Spanish: Goedde et al. [3], Martinez Jarreta et al. [4] and Lisker et al. [5] ; these studied emigrants in Mexico and all of them belonged to the group C, different from a similar group of Italian emigrants with variants C, B and D. No previous records exist from Spain. We have studied 500 serum samples in the province of Granada (Spain) employing the method of Ritchie & Smith [6], and we found 498 C variants and only two genetic B variants, which represent a frequency of 0.40%. We did not find group D variants. Our investigation agrees with studies of other European populations, where D variants are few, and the frequency of B is less than 1% [2], whereas the African and Asian peoples present a high incidence of the D variants. We conclude that the genetic behaviour of the transferrin variants in the Spanish people, like the behaviour of haemoglobins [7], is similar to that in other Western European countries, despite the confluence of different civilizations (Arabic, Jewish and others) who are established in Spain [8–9].