The invention relates to a stackable packaging structure with embedded connecting substrate and a manufacturing method thereof. The packaging structure comprises a substrate, a chip, a first embedded connecting substrate, a circuit layer and a solder mask. The substrate has an upper surface, a lower surface and at least one connecting pad, wherein the connecting pad is positioned on the upper surface. The chip is positioned on the upper surface of the substrate and is connected with the substrate electrically. The first embedded connecting substrate covers the upper surface of the substrate and the chip and comprises at least one plated through hole which passes through the first embedded connecting substrate and connected with the connecting pad of the substrate. The circuit layer is positioned on the first embedded connecting substrate, the plated through hole is connected to the circuit layer, and the circuit layer comprises at least one solder pad. The solder mask is positioned on the circuit layer and exposed from the solder pads. Thus, the packaging structure has more solder pads for input and output. The selection of the packaging structure has high elasticity, and the total thickness of the packaging structure can be reduced.


KATHLEEN CANNING is Arthur F. Thurnau Professor of History, Women's Studies, and German at the University of Michigan (1029 Tisch Hall, University of Michigan, Ann Arbor, MI 48109-1003; e-mail: email@example.com). Her most recent publication is the edited collection (with Kerstin Barndt and Kristin McGuire), Weimar Publics/Weimar Subjects: Rethinking Political Culture in Germany in the 1920s (Berghahn, 2010). She is the author of Languages of Labor and Gender: Female Factory Work in Germany, 1850–1914 (Cornell, 1996; 2nd edition: University of Michigan, 2002), and Gender History in Practice: Historical Perspectives on Bodies, Class, and Citizenship (Cornell, 2006); and the coeditor with Sonya Rose of Gender, Citizenships, and Subjectivities (2002). She was formerly coeditor of Gender & History and currently serves on the editorial board of the Journal of Modern History and Central European History. She is currently writing a book on citizenship and sexual crisis in the aftermath of war and revolution in Germany, 1916-1930.


Pressure Ulcers (PrU) are a severe health problem to patients and a major financial burden to the National Health Service of the UK. The education of nurses, patients, and their careers plays a significant role in PrU prevention. Internet-based learning has offered a flexible and relatively cheap method for delivering the teaching of evidence-based practices, however, the current online education systems still lack dynamic interactivity and the provision of multimedia learning materials. Rich Internet Applications (RIAs), featured as Web-based applications function as traditional desktop applications, and provide the potential for more engaging learning experiences than the current e-Learning systems. This study proposes an adaptive online education system – AMTES which is powered by RIA technologies, primarily Adobe Flex. The preliminary evaluation result indicates that AMTES is capable of providing most students with appropriate multimedia course materials based on an estimation of their knowledge level by the system.


With the rapid progress of storage technologies and communication networks, there has been an explosive growth of digital music information. How to organize and search large scale music collection is one of the most fundamentally challenging research problems. According to the musical form structure and repetition rule of musical theme, repeating patterns can be regarded as the representation of musical themes. Statistical analysis indicates that repeating patterns in music collection also follow Zipf's law. Therefore we introduce a dictionary based indexing approach to organize and index music collection, where the musical dictionary comprises repeating patterns. Then all music melodies are partitioned into words using forward or backward word segmentation method with the musical dictionary. Experimental results reveal that the proposed indexing method can be applied to music information retrieval effectively, and possesses obvious advantages when the scale of music collection increases drastically.


Inhibition of intercellular adhesion molecule‐1 (ICAM‐1) expression can ameliorate the inflammation induced by ischemia‐reperfusion injury (IRI) in animal models. However, current strategies to reduce ICAM‐1 expression have been limited by the lack of stability, poor specificity, and the transient nature of synthesized regulatory molecules (antisense/ribozyme).


The hammerstones that had particular characteristics of the crest formationcaused by repetitive crushing were recently excavated in Neolithic sites whichwere located in the West Central regions. However, studies on the definitionsof terminology or the functions of these stone tools are still insuffi...


The Government and the people of Pakistan have chosen the free way of life which embraces the system of free enterprise. This system has done extremely well in Pakistan. But it differs from free enterprise as understood in the United States. In that country if one has the capital and know-how one can set up any industry, make any goods and sell them at any price. Owing to circumstances which are different in Pakistan, we cannot follow that pattern of free enterprise. We have a large population and our resources are not adequate. So, the Government has to put certain limitations on the system of free enterprise.


Keller and Rubinow(l) have considered the force on a spinning sphere which is moving through an incompressible viscous fluid by employing the method of matched asymptotic expansions to describe the asymmetric flow. Childress(2) has investigated the motion of a sphere moving through a rotating fluid and calculated a correction to the drag coefficient. Brenner(3) has also obtained some general results for the drag and couple on an obstacle which is moving through the fluid. The present paper is concerned with a similar problem, namely the axially symmetric flow past a rotating sphere due to a uniform stream of infinity. It is shown that leading terms for the flow consist of a linear superposition of a primary Stokes flow past a non-rotating sphere together with an antisymmetric secondary flow in the azimuthal plane induced by the spinning sphere. For a3n2 > 6Uv, where n is the angular velocity of the sphere, U the speed of the uniform stream, and a the radius of the sphere, there is in the azimuthal plane a region of reversed flow attached to the rear portion of the sphere. The structure of the vortex is described and is shown to be confined to the rear portion of the sphere. A similar phenomenon occurs for a sphere rotating about an axis oblique to the direction of the uniform stream but the analysis will be given in a separate paper.


As the chinese pension insurance system is reformed deeply,the growth of fisical expenditure will exists great risk.The chinese finanncial crises in transformation of aging of population,urbanization and inflation.The author analyzes the reasons to pension insurance financial risk,and put forward some preventions.


We investigated how the two rounds of whole genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulatory blocks, GRBs). We showed that the majority of GRBs present in the last common ancestor of chordates have been maintained as a single copy in humans. We found evidence that dismantling of the additional GRB copies occurred early in vertebrate evolution often through the differential retention of the regulatory gene but loss of the bystander gene's exonic sequences. Despite the large evolutionary scale, the presence of duplicated highly conserved non-coding regions provided unambiguous proof for this scenario for dozens of ancient GRBs. Remarkably, the dismantling of ancient GRB duplicates has contributed to the creation of large gene deserts associated with regulatory genes in vertebrates, providing a widespread mechanism for the origin of these enigmatic genomic traits.


The HED (Howardite, Eucrite and Diogenite) meteorite clan likely originate from the asteroid 4-Vesta [1]. Howardites (polymict breccias of eucritic and diogenitic material) are believed to originate from the vestan surface, and many contain regolith-like features (impact and/or melt clasts, fragmental breccia clasts, carbonaceous chondrite fragments), which may relate to regolith-formation processes. Noble gas analysis can help determine true regolithic nature, as Solar Wind (SW) is im-planted into grains at the upper-surfaces of solar system bodies lacking an atmosphere or magnetic field. Howardites from Ves-ta s true regolith would thus show evidence for SW components. Thus far, we have identified 5 regolithic howardites: LEW 85313; MET 00423; PRA 04401; SCO 06040 and EET 87513; based on our noble gas analyses, with the latter 3 showing some evidence for a planetary(+SW) component, likely related to CM-like material present in the assemblage [2-5]. However, we did not find a good correlation between SW content and other petro-logic regolithic features. Nor did we find an obvious correlation between SW and high siderophile element contents (Ni greater than 300 micrograms/gram), or an Al2O3 range of 8-9 wt% and eucrite/diogenite (E/D) ratio of 2:1 as suggested by [6] to be further regolith indicators. Here, we report our latest noble gas data for two howardites GRO 95535, GRO 95602 and a polymict eucrite EET 87518 in continuing research aimed at better understanding the vestan regolith. Results: Noble gas analysis was performed on an MAP 215-50 noble gas mass spectrometer using furnace step-heating. Our results, shown in Table 1, are compared with SW- (LEW 85313) and planetary-dominated (PRA 04401 ~60% CM) howardites [2]. EET 87518 is dominated by cosmogenic components. By comparison, both howardites show strong evidence for SW, with total Ne-20/Ne-22 ~8.7-8.8 (SW: Ne-20/Ne-22 13.78 [7]), and identical release patterns to our other CM-poor SW-rich samples. This suggests that these samples are from the vestan regolith. As they have lower Ni contents than suggested by [6], this further illustrates that these parameters may show some bias [2].


Petr Drulak /ed./: National and European Identitites in EU Enlargement. Views from Central and Eastern Europe. 1st ed. Prague: Institute of International Relations, 2001, 224 stran, ISBN 80-86506-11-8


We study the local well-posedness of the initial-value problem for the nonlinear generalized Boussinesq equation with data in $H^s(\mathbb R^n) \times H^s(\mathbb R^n)$, $s\geq 0$. Under some assumption on the nonlinearity $f$, local existence results are proved for $H^s(\mathbb R^n)$-solutions using an auxiliary space of Lebesgue type. Furthermore, under certain hypotheses on $s$, $n$ and the growth rate of $f$ these auxiliary conditions can be eliminated.


In terms of noise removal, the conventional linear filter works well in smooth regions, but significantly blurs the edgestructures of an image. In this paper, we present an adaptive bilateralfilter (ABF) for sharpness enhancement and noise removal. ABFsharpens an image by increasing the slope of the edges withoutproducing overshoot or undershoot The proposed method firstclassifies the pixels into two classes, which are "noise free pixel"and "noisy pixel" based o n t he intensity values. The corruptedpixels are replaced by "alpha trim- mean" value of uncorrupted pixelsin the filtering window. The proposed algorithm work very well forimages with lower percentage of impulse noise also.


Some decentralized developing countries in Asia and Africa have the same problem on patronage leadership. The same of historical story could be influenced of the matter. Mostly the patronage happens in political leadership and business leadership. The actor represents government leadership and business leadership. If the cooperation and collaboration between government and business sector run by the regulation, it will emerge good governance. But in fact, they are tending to break the law and doing corruption. This paper aims to identify and to explain the practical patronage leadership in political and business field particularly in decentralized developing countries. Even this paper doing by literature review, hopely it can perform clearly about patronage leadership. Keywords—patronage; leadership; political; business; decentralized developing countries


Despite the considerable effort has been put on the application of Non-Volatile Memories (NVMs) in Field-Programmable Gate Arrays FPGAs, previously suggested designs are not mature enough to substitute the state of-the-art SRAM-based counterparts mainly due to the inefficient building blocks and/or the overhead of programming structure which can impair their potential benefits. In this paper, we present a Resistive Random Access Memory RRAM-based FPGA architecture employing efficient Switch Box (SB) and Look-Up Table (LUT) designs with programming circuitry integrated in both SB and LUT designs that creates area and power efficient programmable components while precluding performance overhead to these blocks. In addition, we present an efficient scheme to load the configuration bitstream into the memory elements, which makes the configuration time comparable to that of SRAM-based FPGAs. Besides, we investigate the correct functionality and reliability of the programming structure subject to fluctuations in attributes of RRAM cells. Using Versatile Place and Route (VTR) tool with the obtained characteristics of the proposed blocks demonstrate that the average area and delay of the proposed FPGA architecture are 59.4% and 20.1% less than conventional SRAM-based FPGAs. Compared with a recent RRAM-based architecture, the proposed architecture improves the area and power by 49.7% and 33.8% while keeps the delay intact.


Background: Abnormal uterine bleeding (AUB) is a broad term that describes irregularities in the menstrual cycle involving frequency, regularity, duration, and volume of flow outside of pregnancy. The gold standard for diagnosis of AUB is the endometrial biopsy for accurate detection of the exact pathological cause for bleeding. However, due to the invasive nature of this procedure, most of the cases are not complaint for this technique. Ultrasonography is non-invasive technique for evaluating the endometrium. However, using this technique to measure the thickness of the endometrium itself is not sufficient. 3D Transvaginal ultrasound enables an assessment of uterine and endometrial volume. Objective: To assess the accuracy of 3D trans-vaginal Ultrasound in diagnosis of endometrial hyperplasia in women with perimenopausal abnormal uterine bleeding. Patients and methods: This was a cross sectional study that included 75 patients selected from outpatient clinic of Obstetrics and Gynecology at Al-Hussein Hospital, Cairo, Egypt, from January 2020 till January 2021. Detailed history was obtained and full examinations were done for every patient included in the study. In addition, transvaginal ultrasound was done and the endometrial volume was measured, then all patients were submitted to endometrial curettage. Results: Adenocarcinoma was the most reported findings in 27 cases (36%). The best cut-off value for classification of patients into those with benign endometrial pathology and those with endometrial hyperplasia or carcinoma using endometrial volume was an endometrial volume >12.35 ml with 74.1% sensitivity and 95.2% specificity. The best cut-off value for classification of patients into those with benign endometrial pathology or hyperplasia and those with endometrial carcinoma using endometrial volume was an endometrial volume >12.25 ml with 96.3% sensitivity and 100% specificity. Conclusion: 3D ultrasound is a reasonably accurate, helpful and non-invasive tool for assessing the endometrium that could replace the endometrial biopsy.


Abstract OMPHALITIS, or navel infection in baby chicks and poults, has been an increasing problem over the years. Volkmar (1929) described the syndrome of omphalitis and concluded that the increased bacterial content of the air in the incubator at hatching time was the major factor in the production of the disease. Diagnostic laboratories throughout the country have isolated from chicks with omphalitis or sometimes termed "mushy chick," "filth" organisms such as Escherichia coli, staphylococci spp., streptococci spp. pseudomonasspp., and proteolytic anaerobic bacteria. Williams and Daines (1942) found that within 72 hours after hatching, losses ran as high as 30 percent and the causative agent was Staphylococcus aureus. Recent work by Pathak et al. (1960) indicated that from 146 chicks with unabsorbed egg yolks they isolated Escherichia, Aerobacter, Klebsiella and Proteus. They stressed the importance of disinfection of eggs, incubators, brooders and other equipment concerned with chick raising. Very little work has…


We introduce a pseudo-squeezed bosonic ladder operator defined as a time-dependent non-Hermitian linear invariant and related to their adjoint operators via the bounded Hermitian invertible operator or metric operator. In fact, they are obtained from the squeezed transformation of the pseudo-bosons annihilation and creation operators. Thus, the pseudo-bosonic squeezed coherent states are just obtained as pseudo-displacement operator method acting on the ground pseudo-squeezed state. To our knowledge, the time-dependent pseudo-squeezed coherent states have not been constructed until now. As an illustration, we study the time-dependent non-Hermitian displaced harmonic oscillator, and the properties of these states are analysed with respect to the localization in position and to uncertainty principle.


In order to survive in an environment of uncertainty and change, organizations need to implement changes. However, most of these initiatives fail, reflecting the inability of organizations, including health care organizations, to implement changes successfully. This problem may be due in part to lack of knowledge about the concepts of managing organizational change and, therefore, the solution can be empowering organizations and their employees to manage change. One way of achieving this is to provide resources that promote learning from the literature and making decisions based on evidence. Following this line of thought, the main goal of this paper is to review the literature on organizational change and managing change in health care, in order to develop a manual with general information on the subject, aimed at managers and health professionals and adapted to the context of this area. The manual is intended to arouse the interest of readers in change management and to motivate them to facilitate and participate in the processes of change in their organizations. It should not be seen, however, as a guiding resource, by itself, for operating the change initiative. Other practices are also suggested for the empowerment of organizations such as developing a complementary manual with more detailed information and creating an information network on the internet for health and change management professionals.


Previous studies by Sutcliffe and co-workers using exploratory analysis found correlations between environmental variables and lagged annual catch for several Gulf of St. Lawrence and Gulf of Maine fish and shellfish stocks. The present study tests these relationships using recent data. For 6 of the 13 stocks investigated, correlations between the 9–14 yr of new catch data and that predicted from the environmental models remained high (r > 0.5) and of the same sign; however, individually none was statistically significant (p > 0.05) after accounting for the loss of degrees of freedom due to the high autocorrelation in the data. The hypothesis of an overall environmental effect on the landings was considered. It could not be substantiated as the correlation coefficient for 5 of the 13 stocks reversed sign using the new data, but changes in fishing effort are believed to mask detection of environmentally induced variability in the landings of many stocks. The utility of environmentally based predictions was...


This paper reviews the development of the technology for synthesis of ethylene glycol by using natural gas. The synthesis process via methanol to ethylene has been successful applied in industrial plant, but the process via oxalic ester or formaldehyde routes still has some key problems. 


Topological quantum states have been proposed and investigated on two-dimensional flat surfaces or lattices with different geometries like the plane, cylinder and torus. Here, we study quantum anomalous Hall (QAH) or Chern insulator (CI) states on two-dimensional singular surfaces (such as conical and helicoid-like surfaces). Such singular geometries can be constructed based on the disk geometry and a defined unit sector with $n$-fold rotational symmetry. The singular geometry induces novel and intriguing features of CI/QAH states, such as in-gap and in-band core states, charge fractionalization, and multiple branches of edge excitations.


The radiolysis of hexene-1, hexene-2, and hexene-3 at room temperature was studied with particular emphasis on the mechanisms leading to dimer formation. The structures of the hexene dimers were in...


We give an explicit presentation with generators and relations of the quantum cohomology ring of the blow-up of a projective space along a linear subspace.


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THE ADMINISTRATOR ADDRESSED: Subject:  2018 Summer
School Program for English Learners (ELs) in Kindergarten and First Grade 19 Texas Administrative Code (TAC), §89.1250 , Required Summer School Programs, requires Local
Education Agencies (LEAs) to provide a s


Node attributes are ubiquitous in real-world networks, whose fusion with graph topology raises new challenges for the detection and understanding of community structure. Due to their principled characterization and interpretation, probabilistic generative models (PGMs) have become the mainstream methods for community detection in attributed networks. Most existing PGMs require the attributes to be categorical or Gaussian distributed. A novel PGM is proposed here to overcome these limitations. For the generality of our model, we consider the impact of the distances between attributes on node popularity, whose description raises the model selection problem in statistical inference. We present a novel scheme to address this issue by analyzing the detectability of communities for our model, which is also a quantitative description on the effect of node attributes with respect to communities. With the model determined, an efficient algorithm is then developed to estimate the parameters and infer the communities. Extensive experiments have been conducted to validate our work from two aspects. First, the experiments on artificial networks verified the detectability condition for our model. Second, the comparison on various real-world datasets shows that our algorithm outperforms the competitive methods.


The aim of the considerations is an attempt to solve problems related to the interpretation of the concepts of agricultural property, an agricultural holding and agricultural activity as defined in the Act on shaping the agricultural system experienced by notaries in their practice. After the entry of the Act into force, and especially after the amendment of 14 April 2016, there emerged interpretation problems related to the concept of agricultural property, an agricultural holding and agricultural activity, but the practice and doctrine strived to find interpretative solutions despite the difficulties. As a result, however, diverse interpretations of the concepts or terms in question did not serve the stability of the trading in agricultural property. The modifications introduced on the basis of the amendment of the Act of 26 April 2019 were to some extent a response to the dilemmas reported, and as such they must be assessed positively. At the same time, certain controversial issues remain, and example of which is the impact of a change from the designation of agricultural property for non-agricultural purposes into a 5-year obligation to operate an agricultural holding.


The anatase and rutile TiO_2 porous films were prepared directly on the surface of pure titanium by constant voltage and constant current anodic oxidation using sulphuric acid, pure titanium and pure copper as electrolyte, anode and cathode, respectively. The structure of the porous films on the substrate was analyzed by XRD. The effects of the voltage, the concentration of sulphuric acid, the anodization time and the current density on the crystalline phase of TiO_2 porous films were systematically investigated, and the forming mechanism was discussed. The results show that, in 0.5mol/L sulphuric acid electrolyte, the annatase TiO_2 appears at constant voltage (≥80V) or constant current (≥0.6A) and appears immediately after 1min anodization at constant voltage (≥100V), while the rutile TiO_2 appears at constant voltage (≥150V) or constant current (≥0.8A).


This paper stated interaction of cryoprotectant and semen in the process of boar semen cryopreservation,explained the protection mechanism of permeable and impermeable cryoprotectant,reviewed the limitations and research tendency of boar semen cryopreservation,providing a reference for the relevant research of cryopreservation.


The world is hungry for knowledge and quickly-producing researchers of varying caliber who are less dependent on the physical space than ever before. This presents a number of challenges to librarians, out of which issues related to technology stand out prominently. How can the library pave roads to curated digital content and make it easily accessible from any location? How does it remain relevant in the age of Google, sophisticated piracy and the open access movement? The chapter begins with an overview of IP-based and federated access technologies, touching on less-used methods as well. Personally-conducted interviews with library industry experts aim to determine current trends in order to provide a collective insight into future developments. These include the widespread migration towards cloud-based services, the global RA21 initiative, the open access movement, the need for better statistics, and new ways of content delivery, all of which affect libraries' demands for remote access in different ways.


A hybrid radio frequency/underwater wireless optical communication (RF/UWOC) system is considered in this paper. UWOC link provides high data rate and secure communication for various underwater applications, i.e. climate monitoring, underwater explorations and disaster management making it suitable mode of communication and the RF link increases the reliability of the system. The proposed system leverage Selection Combining of the RF and UOWC, which are represented by Nakagami-m and Exponential Generalized Gamma (EGG) faded UOWC link, respectively. Air bubbles, salinity, and thermal fluctuations in the water causes underwater optical turbulence (UOT) affecting the communication system. In this work, the outage and error analyses of the considered hybrid RF/UWOC system is performed. The error performance for different modulation schemes is analysed for the hybrid system. The outage and the error performance is affected by the RF fading parameter, the air bubble concentration, the temperature gradient, and the salinity of the water source.


Twelve patients with either proliferative or preproliferative diabetic retinopathy were managed by continuous subcutaneous insulin infusion (CSII) for periods of from 4 to 19 months. Despite the excellent control of blood sugar achieved by this technique out of the 24 eyes 20 deteriorated, with initiation of neovascularisation in 12 eyes and worsening of new vessels in 8 eyes. Thus photocoagulation remains the treatment of choice for such cases.


The one-pot synthesis strategy of Au@Pd dendrites nanoparticles (Au@Pd DNPs) was simply synthesized in a high-temperature aqueous solution condition where cetyltrimethylammonium chloride (CTAC) acted as a reducing and capping agent at a high temperature. The Au@Pd DNPs with highly monodisperse were shown in high yields by the Au:Pd rate. The nanostructure and optical and crystalline properties of the Au@Pd DNPs were characterized by UV–vis spectroscopy, transmission electron microscopy (TEM), and X-ray diffraction. The Au@Pd DNPs showed an efficient electrochemical catalytic performance rate toward the ethanol oxidation reaction (EOR) due to their nanostructures and Au:Pd rate.


Document image binarization is one of the main preprocessing steps in document image analysis for text recognition. Noise, faint characters, bad scanning conditions, uneven lighting or paper aging can cause artifacts that negatively impact text recognition algorithms. The task of binarization is to segment the foreground (text) from these degradations in order to improve optical character recognition (OCR) results. Convolutional Neural Networks (CNNs) are one popular method for binarization. But they suffer from focusing on the local context in a document image. We have applied a hybrid CNN-Transformer model to convert a document image into a binary output. For the model training, we used datasets from the Document Image Binarization Contests (DIBCO). For the datasets DIBCO-2012, DIBCO-2017 and DIBCO-2018, our model outperforms the state-of-the-art algorithms.


In this article, we present an analysis of air travel choice behaviour in the San Francisco Bay area. The analysis extends existing work by considering the simultaneous choice by passengers of a departure airport, an airline, and an access mode. The analysis shows that several factors, most notably flight frequency and in-vehicle access time, have a significant overall impact on the attractiveness of an airport, airline and access mode combination, while factors such as fare and aircraft size have a significant effect only in some of the population subgroups. The analysis highlights the need to use separate models for resident and non-resident travellers, and to segment the population by journey purpose. The analysis also shows that important gains can be made through the inclusion of airport-inertia variables, and through using a nonlinear specification for the marginal returns of increases in flight frequency. In terms of model structure, the results suggest that the use of the different possible two-level nested logit models leads to modest, yet significant gains in model fit over the corresponding multinomial logit models, which already exhibit very high levels of prediction performance. Copyright (c) 2006 the author(s). Journal compilation (c) 2006 RSAI.


Objective: The aim was to assess marginal adaptation of zirconium crowns made up by manual milling (pantograph) and computerized (computer assisted designing/computer assisted machining [CAD/CAM]) before and after cementation; and the efficiency of 3 types of cements in retaining these crowns: Zinc phosphate, resin modified glass ionomer cement (RelyX Luting 2) and resin cement (RelyX U200). Materials and Methods: Out of 30 zirconium crowns, 15 were milled by the pantograph, and 15 by CAD/CAM. Each group was divided into 3 subgroups according to the cement used. Cementation was done over the analog universal pin 4.5 mm × 4 mm and submitted to mensuration of marginal interface of its four faces with stereoscopic magnifier (×20). Then, they were directed to a machine of universal test (EMIC), and submitted to an axial traction with speed of 0.5 mm/min until its displacement. Results: Before cementation, CAD/CAM crowns (47.60; 40.20; 43.40 μm) demonstrated a greater desadaptation comparing to pantograph crowns (28.20; 35.60; 30.40 μm). RelyX Luting 2 showed less marginal desadaptation postcementation on CAD/CAM crowns (53.80 μm ± 8.43 μm) and pantograph (39.80 μm ± 12.696 μm), when compared with zinc phosphate (62.00 μm ± 12.86; 45.20 μm ± 24.035) and to RelyX U200 (73.80 μm ± 44.49 μm; e 53.00 μm ± 10.817 μm). RelyX Luting 2 also obtained better efficiency on traction resistance (9.48 Kgf ± 2.49 Kgf; e 24.54 Kgf ± 6.73 Kgf), when compared to zinc phosphate (8.71 Kgf ± 4.00 Kgf; and 11.85 Kgf ± 3.15 Kgf) and RelyX U200 (8.08 Kgf ± 0.62 Kgf; and 14.78 Kgf ± 5.94 Kgf). Conclusions: Lower values on marginal discrepancy were found on pantograph crowns comparing to CAD/CAM crowns. RelyX Luting 2 obtained not only a lower marginal desadaptation, but also a better efficiency on traction resistance among the three cements. However, there was no significant statistical difference that could prove the influence of desadaptation on displacement resistance.


The casting microstructure of DC cast 2A12 aluminum ingot prepared with electrolytic aluminum melt has been observed,and the effect of high temperature homogenization on microstructure,mechanical properties and electrical conductivity of hot rolled 2A12 aluminum alloy sheet have been investigated by using of optical microscopy,SEM/EDS,conductivity inspection,DSC analysis and tensile experiment.The results show that there are dendrite crystal features,and in which there are α-Al becomes the trunks of dendrite crystals,while the Al2Cu,AlFeMnCu blocky phases and the Al2CuMg lamellar S phases with distinct eutectic pattern are all distributed along the inter-dendrite trunk evenly.The soluble phases dissolve into matrix very quickly when the alloy ingot being homogenized at 490℃ with no more than 8h holding,whereas the dissolving rate of soluble phases is slow down when the ingot being homogenized at 490℃ with more than 12h holding.There are still some soluble phases remained in the alloy matrix after the ingot being homogenized at 490℃ with 36h holding,even the homogenization is gong at 497℃ with 24h holding,the low temperature soluble phases can not be eliminated thoroughly.But the amount of the remained soluble phases in the matrix of alloy ingot after homogenization at 497℃ with 12h holding is less than those of the alloy ingot after homogenization at 490℃ with 36h holding.There are no noticeable improvement effects on both the mechanical properties and the conductivity of the hot-rolling 2A12 alloy sheet when the homogenization holding time is prolonged from 12h up to 24 h.


Objective To develop doxorubicine-loaded nanomicelles based on a type of novel starshaped 4-arm PLGA-PEG-NH2 amphiphilic block copolymers.Methods 4s-(PLGA-PEG-NH2) synthesized by 4s-PLGA and (H2N-PEG-NH2) according to N,N'-dicyclohexylcarbodiimide(DCC) condensation reaction was demonstrated by 1H NMR spectroscopy and gel permeation chromatography(GPC); DOX-loaded 4s-(PLGA-PEG-NH2) nanomicelles were self-assembled by doxorubicin(DOX) and 4s-(PLGA-PEG-NH2) via emulsion-solvent evaporation method and characterized in terms of morphology,particle size and size distribution,drug loading,encapsulation efficacy,cell uptake and cytotoxicity studies.Results 4s-(PLGA-PEG-NH2) were capable of selfassembling into "core-shell" nanomicelles structure and encapsulating DOX into their hydrophobic cores.The mean size of DOX-loaded 4s-(PLGA-PEG-NH2) was nanometer size; drug loading and encapsulation efficacy were around 7.5% and 75.2%,respectively.Mean surface charge of the micelles was around -17.6 mV.In vitro cell uptake and cytotoxicity studies indicated that comparing to the DOX-loaded linear-(PLGA-PEG-PLGA)nanomicelles,DOX-loaded 4s-(PLGA-PEG-NH2) nanomicelles showed better performance in uptaking by HeLa cells and higher cytotoxicity to cancer cells.Conclusion 4s-(PLGA-PEG-NH2) amphiphilic block copolymers can be successfully used in encapsulating DOX,self-assembling "core-shell" nanomicelles in aqueous solvent.Therefore,4s-(PLGA-PEG-NH2) copolymers can be considered as a promising drug carrier in effectively carrying hydrophobic drug,improving the efficacy while reducing the side effect.

Key words:
Doxorubicin; Polymeric nanomicelles; Star-shaped multi-arm PLGA-PEG; Amphiphilic block copolymer


Connecting with the engineering practice,this paper introduces in detail the technical emphases of the steel fiber reinforced concrete deck surfacing construction,and points out that the steel fiber reinforced concrete deck surfacing construction,which can improve the concrete tensile strength and shearing strength obviously,must be supported by a set of scientific construction methods and workers' careful operation for making the deck smoothness achieve higher level.


Errors occurred in the article by Kumar et al, titled "Platelet Transfusion for PDA Closure in Preterm Infants: A Randomized Controlled Trial" published in the May 2019 issue of Pediatrics (2019;143[5]:e20182565; doi:10.1542/peds.2018-2565). On page 1, in the Abstract, the third sentence of the Results reads: "In the liberal transfusion group, 41% of infants had any grade of intraventricular hemorrhage compared with 4.5% in the restrictive group (P = .009)." This should have read: "In the liberal transfusion group, 40.9% of infants had any grade of intraventricular hemorrhage compared with 9.1% in the restrictive group (P = .034)."


This paper applies models of price discrimination to the motion picture industry. Movies are durable goods with no resale market. Therefore, price discrimination using time can be used. The distributors release the movie in two different periods: theaters and video. The first is a high quality product and the second is a low quality product issued in a later point in time. The quality gap between the two versions of the product has shrunk as the DVD technology penetrated the market. This paper compares two years: 1995 and 2000. Initial results show a difference between the two years. The most evident one is a shrinkage of the time between the theatrical release and the video release


Recently, the emergence of sharing-bikes exerts a significant impact on citizens' daily travel. However, when planning bus routes, the current system still does not take them into consideration. In this paper, we propose B&B, a data-driven system to plan bus routes with the consideration of sharingbikes. Aiming to maximize the travel flow coverage, we design a heuristic approach to extend bus routes. Meanwhile, we propose a function to determine whether a road segment should be designed as a bus route or it is more suitable for passengers to ride sharing-bikes in that area. Moreover, to ensure the efficiency of bus routes, a constraint is set up on the directness of bus routes. Extensive evaluation of two large-scale datasets in New York City demonstrates that our system achieves the best coverage on both flows and areas, which outperform by 7.05% and 15.55% over the baselines without consider sharing-bikes. Our system lays a solid foundation for planners to plan the city transportation systems overall, especially concerning the design of the bus routes and sharing-bike lanes.


The purpose of this research was to test and analyze the effect of the credit provided, level of Liquidity and capital adequacy level of profitability of the banking company registered at Bank Indonesia. Population taken in this research is banking companies listed on Bank Indonesia of 2007-2009. Samples taken by using centrifugal purpose sampling, namely samples selected on the basis of conformity characteristics by criteria determined. criteria obtained samples prepared 38 company. To test hypotheses asked in this research data analyzed by using test linear regression of multiple. Based on the results of the analysis can be inferred that variable (1) credit given the positive effect of the Return On Asset with a level of significance of 0.046. The greater the amount of credit given then the greater the ROA to be retrieved anyway.(2) there has been a positive influence on the Return On Asset Liquidity with a level of significance of 0.001. The higher the LDR at a low liquidity increasingly impacting companies and (3) Capital Adequecy Ratio effect positively to Return on Asset with a level of significance of 0.030. That the capital ratio is very important in the business of banking activities in operasinalnya in order to run smoothly. Keyword :Credit, Loan to Deposit Ratio, Capital Adequecy Ratio (CAR) and Return On Equity (ROA).


The real part of the shear mechanical impedance has been measured for three smectic liquid crystals using a shear-wave reflection technique. Results at 30 and 450 MHz are considerably lower than those expected for an isotropic, Newtonian fluid, suggesting the existence of viscoelastic relaxation.


Chronic radiation enteritis is a complication induced by radiotherapy for the treatment of abdominal or pelvic retroperitoneal tumors,which mostly occurs at 6 to 24 months post-therapeutically.It is easily misdiagnosed as primary tumor,recurrent tumor or benign inflammatory bowel disease.This article discusses the diagnosis of chronic radiation enteritis in the view of radiology.


The reconstruction of a Sturm–Liouville potential from finite spectral data is considered. A numerical technique based on a shooting method determines a potential with the given spectral data. Convergence of reconstructed potentials is shown and numerical examples are considered.


As indicated by the existing research findings,subject to the relatively stable group characteristics,the effectiveness of different sources of public transit travel information in the transportation hub is directly influenced by the perceptibility of the transit signs. This paper,based on sufficient RP investigation in 13 public transit hubs and relative data,analyzes the relationship between the quantity of information on a transit sign and the perceptibility of the transit sign,and operates a series of simulated experiments. From the angle of the perceptibility of the transit signs,the threshold value of transit sign information overload in the transit hubs is closely discussed. In the course of analysis,an approach to ascertain the threshold value of transit sign information overload in the transit hubs is developed based on the fuzzy appraisal method.


This paper presents an analysis of the possibilities for the application of a two-dimensional model based on a circumferential strip of soil–steel structures that used results of measurements on railway soil–steel bridges. The distribution of a live load in the model was based on the so-called collocation point method. The method assumed conformity of results coming from a real test and those obtained in the two-dimensional model at a certain point of a structure. As a conformity criterion, deformation or internal forces (e.g., bending moment, thrust force, and stress) was assumed. Two locomotives moving above the structures were used to obtain influence lines of the collocation point. Examples of influence lines are presented; these also could be used for determination of stiffness of soil–steel bridges. The main advantage of this approach is the ability to evaluate the effects of any moving loads applied on existing bridges according to findings of measurements of deflections and development of deflection influence lines.


: Ketobemidone is a mu receptor agonist, available in Scandinavia in a combined preparation (Ketogan$$), which contains ketobemidone and the spasmolytical agent 3-dimethylamino-1, 1-diphenylbutene (A29) in a one to five ratio. A29 is chemically related to methadone and experiments in rats have shown that A29 potentiates the analgesic effect of ketobemidone (Petersen 1951). We have recently shown that ketobemidone has lower binding affinity for the total mu receptor than morphine. At $$-binding sites the two opioids have equal affinity, whereas ketobemidone has much lower affinity than morphine to the $$ receptor (Christensen 1993). The existence of two subtypes of mu receptors has been suggested by Pasternak and co-workers: a high affinity, mu1 receptor subtype that appears to mediate supraspinal analgesia and a low affinity, mu2 subtype that appears to mediate spinal analgesia, respiratory depression and inhibition of gastrointestinal motility (Clark et al. 1988; Paul et al. 1989).


This study aims to analyze the factors that can affect the supply of Indonesian salt. The method used is quantitative method using ordinary least squares (OLS) with a multiple linear regression model. The type of data to be used in this study using secondary data time series year 2000-2014. The data are taken from a variety of sources, including the Central Bureau of Statistics, Ministry of Commerce, Ministry of Industry, Ministry of Maritime Affairs and Fisheries and other resources related to the research. The results of this study showed that the factors that significantly affect the salt deals in Indonesia is the rainfall and the PUGAR and technology not significantly. Negative coefficient of rainfall that can be explained that when there was an increase in precipitation will result in salt deals in Indonesia will go down. While the PUGAR can increase the supply of salt


The outstanding electrical and mechanical properties of single-walled carbon nanotube (SWCNT) thin fi lms [ 1 ] have brought them to the forefront of materials research for a variety of applications including transparent conductors. [ 2–4 ] While as-produced SWCNT samples inherently contain a variety of tube diameters and chiral angles, leading to a mixture of metallic and semiconducting tubes that presents challenges for practical electronic applications, density gradient ultracentrifugation (DGU) has enabled the isolation of large quantities of electronically monodisperse material. [ 5 ] Transparent conducting fi lms fabricated using DGU-sorted SWCNTs have been well-characterized [ 6–8 ] and the advantages of using monodisperse metallic SWCNTs have been demon-strated in devices such as organic photovoltaics. [ 9 ] However, these metallic SWCNT samples are comprised of several species with varying diameters and thus exhibit broad optical transitions, which both hinder optoelectronic applications where sharp spectral features are required and impede empir-ical studies aimed at elucidating the dependence of SWCNT properties on nanotube diameter. Efforts to further refi ne electronically sorted SWCNTs by diameter have typically relied on using starting material from different fabrication techniques such as high pressure carbon monoxide conversion (HiPCO), [ 10 ] laser ablation, [ 11 ] and electric arc discharge [ 12 ] that, when sorted via DGU, provide electronically monodisperse SWCNTs centered about a different tube diameter according to the synthesis method 5 , ,


Increase of photoelectric conversion efficiency of photovoltaic device and,meantime,decrease of its cost is the key for the photovoltaic device to enter into its large-scale application.According to the basic structure of crystalline silicon solar cell,a detailed analysis of physical factors and formative mechanism of its several efficiency losses is made and a quantitative result of primary loss distribution is given,which will be instructive to design the device structure and optimize the manufacturing process of solar cells.


We provide a Liouville principle for integration in terms of elliptic integrals. Our methods are essentially those of Abel and Liouville changed to modern notation. We expose Lie theoretic aspect of Liouville's work.


Objective To study the antitumor effect of periplocin from Periplocae Cortex and explore its possible mechanism in vivo.Methods Murine hepatocarcinoma H22 cells were cultured in vitro,and then passaged in abdominal cavity of BALB/c mice.H22 Cells were collected and sc injected into each BALB/c mice to establish animal model of tumor-bearing mice.Different doses of periplocin (0.25,0.50,and 1.00 mg/kg) were ip administered to the tumor-bearing mice once a day for continuous 15 d.The kinetics of tumor formation and tumor growth were measured,tumor growth inhibition rate(IR) was calculated.The tumor samples were taken,the effects of periplocin on cell cycle and cell apoptosis were determined by flow cytometry,and the ultrastructural changes of tumor cells were observed by transmission electron microscopy in tumor-bearing BALB/c mice after treated with periplocin.Results Marked inhibition of periplocin on the hepatocarcinoma H22 transplantation tumor was observed in BALB/c mice.The tumor formation was significantly retarded and tumor growth was inhibited in periplocin-treated groups compared with those in negative control mice.The inhibitory rates were 60.28%,68.09%,and 74.47% in three groups treated with low,middle,and high dosages of periplocin,respectively.The proportion of tumor cells in the G0/G1 phase was increased markedly,of which S and G2/M phase cells decreased, after treatment with different doses of periplocin,compared to control group,the difference was significant(P0.05),in 1.00 mg/kg group,G0/G1 phase cells increased from(46.90±5.80)% to(83.80±2.52)%,S and G2/M phase cells were decreased from(38.30±5.11)% and(14.80±0.70)% to(5.33±2.73)% and(10.87±0.25)%.The apoptosis rate of tumor cells increased significantly in three periplocin groups(P0.01 vs control group),the highest rate reached(32.35±1.75)% in 1.00 mg/kg group.Furthermore,typical subdiploid peaks were also detected in periplocin-treated groups.Observing the ultrastructure,many typical apoptosis cells were displayed in periplocin-treated groups,whereas,many meta-bolism vigorous tumor cells with more mitochondrion and endoplasmic reticulum were seen in control group.Conclusion Periplocin has significant inhibition on tumor growth in vivo,which is probably related to blocking cell cycle and induction of apoptosis.


The aim of this study was to analyze food security improvement strategy in line with the potency and problems, so that the utilization of village funds is more optimal and on target in order to support the financing of food security in Kuwu village, Dempet Sub-district, Demak Regency. The type of this research is quantitative research by using SWOT analysis. This research used primary and secondary data. The results of analysis showed that the utilization of Kuwu Village Fund was more concerned with physical development as well as transportation facilities and infrastructure. The results of SWOT analysis showed that the appropriate strategy to improve food security through the use of Village Funds in Kuwu Village is to support aggressive growth policy by maximizing the strengths and opportunities such as increasing food production capacity by intensification and diversification, human resource development, and improving the road infrastructure of farmer business.


This study aims to determine the best probiotic concentration and shelf life by adding the probiotic bacteria which were compared by using two types of probiotic bacteria in order to improve the quality and shelf life of Mozzarella cheese from buffalo milk. Fresh raw buffalo milk from Sumbawa and starter cultures of Lactobacillus casei and Lactobacillus bulgaricus were used from Pusat Studi Pangan dan Gizi, Gadjah Mada University. The coagulants were calf microbial rennet (Mucor miehei) and citrit acid derived by Husbandry Laboratorium of Mataram University.The study was designed through using complete two factorial randomized design with treatment concentration of each types of probiotics are 10% until 15% and storage time for 0, 7, and 14 days. The results of the research showed that the probiotic concentration and the storage time influence on chemical, organoleptic and microbiological quality of Mozzarella cheese in which containing L. casei and L. bulgaricus. Based on the organoleptic quality, panelists preferred the Mozzarella cheese with poured of 10% L. bulgaricus. The pouring of probiotics with the storage time for 14 days can suppress microbes growth until safe for consumption with total microbe <2,8 x 10 CFU/ml. The pouring treatment of cultural bactery L. bulgaricus is 10 % recommended as the best treatment that approximate the similar results with generally Mozzarella cheese characteristics.


This study analyses whether family control impacts the firm's capital structure and if results are influenced by financial turbulences. Using a sample of Portuguese listed firms during fourteen years, results show that family and-non family firms have different debt levels in periods of expansion. Moreover, the higher concentration of family ownership leads to reduction in the firm's leverage, especially in recession periods. These results confirm the behavioural-agency theory: the family looks to socio-emotional wealth but assuring the firm presence for future generations.


A direct quantification method consisting of soil compaction and real-time PCR was applied to quantify the potato cyst nematode (PCN), Globodera rostochiensis, in soil. We also compared the efficacies of pre-treatment methods for disrupting nematode bodies and obtaining homogeneous soil samples between soil compaction and ball milling. PCN was detected at a density of five second-stage juveniles (J2)/20 g of soil and there were highly significant correlations (r2 > 0.8697) between the cycle threshold (Ct) values and the number of J2 inoculated in all the soils, irrespective of the pre-treatment methods. Calibration curves showing the relationship between Ct values and nematode density were almost identical for both pre-treatment methods in two soils, while the Ct values were consistently lower for the ball milling method in one soil, suggesting that DNA extraction efficiency might be better in the ball milling method. The calibration curves obtained with the ball milling method were nearly identical in three soils, but were different with the compaction method. These results suggest that the ball milling method is more suitable for direct quantification of nematodes than the compaction method.


Introduction: Sleep related breathing disorders (SRBD) influence the human homeostasis by sleep fragmentation, intermittent hypoxia (IH) or a combinations of both. Effected compartments include the immune system and metabolic parameters. We investigated if patients with or without IH demonstrate different patterns. Methods: 87 participants were divided into 4 groups: healthy controls (C: n=24), patients with sleep fragmentation related to increased upper airway resistance but without IH (UAR: n=19), obstructive sleep apnea (OSA) with (oOSA: n=25) or without obesity (noOSA: n=20). Following polysomnographic recording we analyzed perforin and granzyme-B (GrB) positive lymphocyte subpopulations and fasting routine analysis. The Kruskal-Wallis test and related multiple comparisons were used to compare groups. Results: All three SRBD groups revealed a decreased percentage of perforin + CD3 + gd-T cells when compared to controls. However, after adjustment calculation, only oOSA remained statistically significant (p + CD4 + , CD3 + CD8 + , CD3 - CD8 + , CD3 + CD16 + /CD56 + and CD3 - CD16 + /CD56 + lymphocytes. Serum Gamma-Glutamyl transpeptidase was higher in all three SRBD groups, while elevated triglyceride was only detected in both OSA groups. Only oOSA was associated with significantly higher glucose and C-reactive protein values. Conclusion: Compared to controls we found significantly different results in patients with SRBD. A reduced percentage of perforin + CD3 + gd-T cells was encountered in all three SRBD groups, while other results were linked to IH. This study indicates a possible systemic effect of non hypoxic SRBD.


This empirical study is based on the author's PhD thesis. It aims at rescuing from the Sands of Time the spirit of the destination under analysis, basing itself on the data collected from 1930s newspapers, besides contemporary approaches to that decade in the fields of Political History, War, Tourism, and Leisure. In 1910 the Figueiredos were led to www.isce-turismo.com THIJ – Tourism and Hospitality International Journal ISSN: 2183-0800 Revista semestral gratuita de distribuição digital / Free biannual journal of digital distribution E-mail: firstname.lastname@example.com 75 Estoris due to the microclimate, and by 1914 the entrepreneur invested on a local project meant to erect Portugal's 1 st international resort built from scratch. The plan was accomplished even after the Republican regime made way for the military and civilian dictatorships, for as Hall defends authoritarian regimes do not repel tourists. Estoril was then propelled by the Gambling Law and, as Gibbons wrote in 1936, it soon attracted the mighty and the fallen, mainly of British and Spanish origins. This recollection begins with a summary of the delicate Iberian context between 1910 and 1939, and then refers the Sunny Coast as the unofficial stage of the Spanish Civil War, for since 1931 characters like General Sanjurjo settled as refugees. These visitors were pampered thanks to a ViceConsulate (Cascais), a hotel managed by Galician partners (Monte Estoril), a multitude of leisure delights (Estoril), and Parede's Radio Club. The Sunny Coast's support to Franco soon led to rumours that drove tourists away, hence the reference to the strategies applied to overcome them. One shall finish by mentioning the current reality of equipments and the weak historic memory, whose proper recovery might allow to create a new cultural offer linked to the contemporary 'Cascais' destination for this neighbouring niche market.


Hazardous levels of alcohol use have caused many diseases, posing a great economic and social burden to the community. Alcohol use in some provinces of Vietnam shows that alcohol consumers are getting younger and younger. This study aimed to determine the proportion of alcohol consumption among students at Binh Phuoc Ethnic Minority High School in 2020 and a number of factors leading to the alcohol consumption. The result showed that the alcohol use proportion in the past 12 months was 62% and the risky drinkers rate was 11.2%. Some factors concerning the use of alcohol among students such as gender, age, grade level, behavior, smoking, alcohol use family members, alcoholic friends, and friends influence were also revealed in the study.


Although it is true that computers make one's work significantly easier during some of the work phases of creating an author's dictionary, our goal is to completely revise conventional computer-based dictionary work processes as well as to extend the possible range of applications for author's dictionaries. In our study we examine the role of the digital author's dictionaries in humanities research. We developed the extended digital author's dictionary based on the oeuvre of Kelemen Mikes (1690-1761). We present the advantages of the extended digital author's dictionary and demonstrate its benefits in literary and linguistic research. The main advantages of our system include easily accessible up-to-date encyclopedic information and the improved efficiency of historical text analysis methods. The benefits of the extended functions of the digital author's dictionary help scholars answer more specialized and complex research questions, and reconsider expectations towards the new generation of author's dictionaries.


It is proposed to reflect on the strategies for reorienting the training and processes of Continuing Education in Health, by observing of intersectoral management instances of these movements. Ponders about the move of social subjects that comprise the known four-way approach (teaching, management, care and social control) in the formation, the dynamics of training/education, represented by the figure. It is considered that with this structure, the four-way approach, sometimes not reaffirmed as such, now missing elements to fit the vertices, sometimes with the use of other elements in the same segment, setting up what can be defined as "prism", in addition to four-way approach. Reflections are caused by the action of the four-way approach, but, in addition, the dialogical relationship of subjects generate significant opportunities of the prisms that translate best complexity, the wealth and the power of education movements in health.


The development of extracurricular activities that are part of self-development at school is very important. In addition, many schools are known to the public because of their achievements in the academic field, yet there are not a few schools are chosen by the community because they have achievements in nonacademic fields, including through extracurricular activities. To be able to improve extracurricular achievements from students, management is needed as a part of education. MAN 3 Cirebon has a number of achievements in the field of extracurricular activities and won both district and provincial levels. Based on the background above, the authors conducted the study to reveal how the management of extracurricular programs to improve students' non-academic achievements in Cirebon 3 MAN. The evaluation process carried out is by determining the extent to which educational goals can be achieved through written test and practice which would be followed by an extracurricular team coordination meeting, where principals and parties involved in extracurricular activities to discuss developments and the obstacles faced during the implementation of extracurricular activities and solving the solution to be repaired in the next semester. The implication of this research is to increase the non-academic achievement of students through extracurricular programs, including training discipline, training students' talents, and schools are known to the wider community.


adults usually presents as the common cold and therefore does not prevent normally healthy family members from visiting nursing home residents and personnel with an RSV infection from going to work. Going to work while sick is known as presenteeism and has recently been recognized as a potential public health hazard in addition to creating an economic problem. Children and elderly adults benefit from intergenerational geriatric remotivation implemented through in-house child day care. Because young children experience many infections during their first years of life, including RSV, they can be a potential source of infection. This downside should be taken into account in the nursing home infection prevention strategy when implementing intergenerational geriatric remotivation. There is no vaccine against RSV, so only general infection prevention strategies can be applied in an attempt to avert introduction and nosocomial spread, as the affected nursing home did by following nursing home– specific guidelines. In addition, the architectural structure of the affected nursing home limited the outbreak mostly to one unit by isolating and cohorting of infected and directly exposed residents through the distance between the separate units. In conclusion, this letter describes a mild outbreak of RSV-B in a nursing home and, in addition to sick visitors as a potential source of the infection, identifies two other not widely recognized possible modes of introduction: presenteeism and intergenerational geriatric remotivation. These findings underscore that, in developing strategies for prevention of introduction of infectious diseases in nursing homes, all three sources should be taken into account.


With the research of desktop core security configuration standard and the function demand of desktop configuration management system,this paper proposes a system of desktop security baseline management based on the Microsoft's baselines,in the background of the security operation management of large enterprises servers.This system consists of the baseline management console and the client service,can customize baselines,distribute and deploy baselines,discover the non-compliance configurations,inquire the baselines' information.It provides a unified configuration management and monitoring platform for enterprises and institutions to implement the security configuration management.


We describe gapped single-particle and collective excitations across a superfluid to insulator quantum phase transition of particles (bosons or fermions) in a periodic potential, with an even number of particles per unit cell. We demonstrate that the dynamics are controlled by a quantum impurity problem of a localized particle interacting with the bulk critical modes. Critical exponents are determined by a renormalization group analysis. We discuss applications to spin oscillations of ultracold atoms in optical lattices and to the electronic phases in the cuprate and related compounds.


In a non-uniform memory access machine, the placement of software threads to hardware cores can have a significant effect on the performance of concurrent applications. Detecting the best possible placement for each application is a necessity for thread scheduling. Yet, due to the difficulty of this problem, operating-system schedulers do not really try to understand the needs of applications, but rather focus on (non-portable) scheduling heuristics.In this paper, we introduce thread-placement learning (TPLE), a technique for understanding the placement requirements of applications. TPLE utilizes machine learning and performance counters for choosing between different placement policies. To feed the machine learning model, TPLE requires a set of portable microbenchmarks that produce training data—i.e., performance counter measurements—for all the target placement policies. We use this data to train a classifier that is able to choose between these policies online in order to change the thread-placement of a running application.We demonstrate the practicality of TPLE by implementing a thread-placement algorithm, named Slate. Slate is able to automatically and online (i.e., in runtime) select between the two most commonly-used placement policies, namely locality and round-robin placement on the nodes of a multicore. To the best of our knowledge, Slate is the first online thread-placement algorithm that utilizes machine learning in combination with performance counters. We evaluate Slate and show that it achieves up to 93% accuracy in its decisions and outperforms the Linux scheduler by up to 16%.


It emerged a host of recluses in the time of Dongjin and Nan Dynasties. Most of them lived in beautiful mountains. This showed a relative concentrative feature in regional distributions. The formation of the distributions was decided by the special demands of the recluses, and it caused some effects on the development of social culture and tourism at that time.


An engine gas turbine having a compressor (18) including a phase (30) guide vane inlet, wherein the vane stage inlet guide includes a plurality of blades (38) of guide variables arranged between a housing (40) of the stator and a reinforcement (42) interior blade, said reinforcing arcuate configuration being and being formed by a plurality of arcuate shroud sections, wherein the reinforcement includes a shoulder (66) recessed hole and for each vane (38) a set of contact between blade and reinforcement, wherein the contact assembly characterized by: a bushing (68) held removably in an opening (60) of the reinforcement of the blade to accommodate a support ( 62) rotating the blade; a washer (70) located between a face of said bushing (68) or the flange (66) of the reinforcing recessed hole (42) therein and a ring (64) trunnion of the vane; and a device (74) holding sealing reinforcement can be removably coupled to the outer surface of the reinforcement (80, 82) and disposed thereon to capture said bushing between the shroud and said retainer, wherein said device (74) is a unitary retaining component of arcuate configuration and spanning the plurality of arcuate shroud sections.


The cost for forestry logistics in Sweden is about 25 percent of the total cost of getting the raw material to industry (Anon., 2010). There might be much to gain by taking a look at your supply chains on the logistic side in your company. In this report the logistic chains by Mellanskog for ENA Energi AB in Enkoping has been looked in to. ENA Energis plant is a combined power and heating plant and about 99, 5 percent of their fuel consisted of bio energy in year 2009 (ENA Energi, 2011, lank A).
The main purpose with this report is to look at three questions:
1. How does the supply chain look today? From forest to industry.
2. Identify alternative supply chains or optimizations. From forest to industry.
3. Compare the alternatives in question 1 and 2.
The report looked into a few different optimizing programs used in forest industry today and what use ENA Energi would have of using these types of programs.
ENA Energi uses suppliers for getting the fuel they need, therefore optimization programs might not be applicable for ENA Energi to use.
Their business is too small to have an own buy organization. One recommendation is to discuss with their suppliers and require optimizations of their transports in a way that benefits ENA Energi as a company.


Sickle cell anemia is one of the most common genetic diseases in the United States. Reliable techniques for diagnosis in newborns are available, and detection at birth with treatment can reduce morbidity and mortality.14 Despite this, newborn screening for hemoglobinopathies has been introduced slowly in the southeast. Cooperation, stimulated by the Southeastern Regional Genetics Group (SERGG), has facilitated implementation of statewide screening programs in Region IV. Discussions in sickle cell workshops at SERGG meetings led to formation of the TASCS (Technical Assistance for Sickle Cell Screening) Force which is funded by a SPRANS (Special Projects of Regional and National Significance) grant to assist with development of such programs. TASCS Force consultants represent adult and pediatric hematology, medical genetics, laboratory medicine, social work, public health, community-based counseling, and education programs. Consultants are available a t no cost to the states within the region to assist with problems related to planning or implementing screening programs. Initially, TASCS Force representatives made visits to stimulate interest in screening within state public health departments. In the past two years, regional newborn screening activities have grown from one statewide and several center-based programs to implementation of or planning for statewide screening in every state. Of the nine states in the region, four have statewide screening, four are in the process of starting statewide screening, and one is in the active planning stage. Each state in the region is using a somewhat different approach (see TABLE 1) based on individual strengths and needs. A number of recurring problems related to implementation of statewide screening, which are common to all of the states, have been recognized (TABLE 2). Consultants


Sulphasalazine has been used for many years in the management of inflammatory bowel disease and more recently in chronic inflammatory conditions such as rheumatoid arthritis and ankylosing spondylitis (1). The mode of action of this compound is unclear although there have been suggestions that it acts by inhibiting folate-requiring enzymes, prostanoid formation or catabolism, leukotriene biosynthesis and histamine release from mast cells (for references see 2). Within the cardiovascular system, sulphasalazine inhibits the activation of neutrophils (3) and platelets (4) and may cause thrombocytopaenia (5) and anaemia (6). We now describe an additional and hitherto unreported pro-fibrinolytic effect of this biologically very diverse substance. Male rats (Sprague-Dawl.y, 25U300 g) were anaesthetised with urethane (1 glkg, i.p.). Heparin was injected via a cannula inserted into the femoral vein and 10 min.later 0.6 ml blood was removed via a cannula tied into the carotid artery. Blood was replaced with an equal volume of saline. Sulphasalazine or an appropriate volume of diluent (0.5% w/v Na2CO3) was injected intravenously and a further 0.6 ml aliquot blood removed at 15, 30 or 60 min thereafter. All blood samples were further anticoagulated with 0.06 ml trisodium citrate (3.8% ilv) and centrifuged (1,000 g, 10 min) to produce plasma. The total volume of blood removed from a single animal was 1.2 mL Euglobulin fractions were prepared by acidification of citrated plasma to pH 6 with 0.1 M acetic acid and the resulting precipitate centrifuged (1,000 g, 10 min) and resuspended in 0.01 M barbital buffer (pH 7 .4). Fibrinolysis was assessed by the fibrin plate procedure as described elsewh ere (7) 30 pl resuspended euglobulin proteins prepared from rat blood before sulphas alazine injection lysed 98 + 2 mmz (n 46) of the tibrin film. In control experiments, sulphasalazine (10 mM) added to blood from such control rats prior to euglobulin precipitation did not influence fibrinolysis (104 * 8 mm2 fibrin lysed, n 5). Similarly, addition of sulphasalazine (10 mM) to euglobulin fractions prepared from control rat blood also failed to stimulate fibrinolysis (102+6 mm2 fibrin lysed, n:6). In contrast, administration of sulphasalazine to the intact rat resulted in a dose and time related increase in blood fibrinolytic activity (Thble 1). The minimally effective dose of sulphasalazine (5 mgl kg) increased fibrinolysis within 15 min of injection. Fibrinolysis


Nanofillers: Chitin nanofibrils modified with PEG (CN-PEG) were done at a 2% water suspension of CN (pH 1.9) neutralized at pH 7 by a 10% water solution of NaOH, is slowly added a 2% water solution of PEG at room temperature by a slowly mixing. Soon after the suspension is spray dried to obtain a light brown powder consisting of the spherical particles with diameter in the range from 10μm to 67nm.


On apprend plus par la conversation des Doctes, que par la lecture de leurs livres Les épistres de Seneque Translation by François de Malherbe, Paris, Anthoine de Sommaville, 1639, p. 21 Small and medium-sized enterprises, because of their limited resources, use a variety of sources and are linked to different networks to obtain the information they need to develop their strategy and then to gradually organize their environment. Among other things, networks keep them up-to-date with changes in the economy and allow them to take advantage of opportunities to innovate, thus remaining ahead of their competitors. The networks – personal or business – with which these firms interact the most are usually geographically or sociologically close by, embedded in the environment, and are known as strong tie networks. They generally supply signals in a familiar language, based on habit as well a good reciprocal knowledge, which are easy to understand. In addition to this, however, the most dynamic firms also have contacts with weak tie networks, which are further removed from the usual behaviours of entrepreneurs and provide weak signals that, while difficult to grasp and decode, nevertheless offer new, pre-competitive information that can support major innovations. Very little empirical research has been done so far to test the probability of this theory. This paper reports on the results of a survey involving 147 SMEs, all in the land-based transportation equipment sector. It confirms the importance of weak tie networks as opposed to other types of networks, recognizing their complementary contribution to technological innovation. The organization's absorptive capacity is also found to be a significant intermediary factor in taking advantage of weak tie networks.


Aleuropleurocelus caudatus Sánchez-Flores and Carapia-Ruiz sp. nov. collected in Asunción Ixtaltepec, Oaxaca from the underside of leaves of Coccoloba uvifera, and Aleuropleurocelus bidentatus Sánchez-Flores and Carapia-Ruiz sp. nov. collected in Acapulco, Guerrero from the underside of leaves of Diospyros acapulcensis subsp. acapulcensis are described and illustrated. Figures of morphological structures of the puparia are provided, and differences from other Aleuropleurocelus species are discussed.


Four purely chiral supramolecular frameworks were constructed from a new chiral terpyridyl ligand, (S)-2{4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]benzylamino}propanoic acid (H2ptpy). The resulting compounds 1–4, namely [Cd2(Hptpy)2(Ac)2]·3CH3OH·H2O (1) [Ni2(Hptpy)2(CH3OH)(H2O)](ClO4)2·CH3OH·H2O (2), [Ni2(Hptpy)2(H2O)2](SCN)2 (3), and [Cu2(Hptpy)2](dca)2·4H2O (4) (Ac = acetate and dca = dicyanamide) all consist of those chiral metallocyclic units. As expected, those chiral nanometallocycles not only induced a chiral array or helicates but also amplified chirality through hydrogen-bonding interactions, and finally aggregated into complicated higher-dimensional chiral supramolecular architectures with chiral voids for further use. The formation of the metallocyclic units is easily monitored by UV/Vis spectra. Spectrophotometric titrations were performed by titrating Na(Hptpy) with a soltution of Cd(Ac)2 in methanol, and the global stability constants of [Cd2(Hptpy)2]2+ (log β = 17.60) were calculated. In combination with the structural analyses and UV/Vis and ES mass spectra, it is tentatively deduced that metallocycle units in 1–4 are the thermodynamically favored species in solution. Both the chiral H2ptpy ligand and 1 in the solid state and in solution display purple emission. The bathochromic shift of 1 is mainly due to the bichelation and intrametallocyclic π–π interactions.


Mathematical modeling and simulation of an experimental study was performed using an array of solar panels to power three non-asbestos diaphragm type electrochemical cells whose anodes consisted of carbon rods and cathodes made up of stainless steel plate for the electrolysis of a 25 % w/w sodium chloride solution, with the aim of producing caustic soda. The non-asbestos diaphragms served to hinder the formation of unwanted substances as well as permit reasonable production of the desired products. The three non-asbestos diaphragm cells exhibited various characteristic performances, which is a reflection of their design, fabrication, composition, intensity of the sun on any particular day, the length of time the panels were exposed to sunlight and operational parameters. The non-asbestos diaphragm D3 with composition of 60 % w/w Portland cement, 20 % w/w silica and 20 % w/w polyvinyl chloride (PVC) indicated the highest yield of caustic soda per d.c Watt with specific electrical energy supplied. The simulated values predicted the operation closely as the maximum positive and negative deviations of all modeled from experimental values are between +0.07 and –0.06 respectively. The research served as an encouraging inquisitive foundation into the possibility of producing caustic soda directly from solar powered electrolytic diaphragm cells with the aim of designing better cells as well as investigating key factors that affects cell performance in view of present conventional modes of electrochemical production.


In this article, the finite-time stability analysis and stabilisation for switched continuous linear system are addressed. Several sufficient conditions for finite-time boundness and stability of switched system are proposed in this article. By comparing the proposed results, it is shown that more the information about the switching signal is known, less conservative results can be derived. Then, based on the finite-time stability analysis results, static state and dynamic output feedback controllers are designed to finite-time stabilise switched linear systems. Several numerical examples are given to illustrate the proposed results within this article.


Abstract There is a dominant seesaw pattern in summertime precipitation between northeast Asia and Siberia. Examined here is a mechanism of the seesaw mode, focusing on quasi-stationary Rossby waves propagating on two upper-tropospheric waveguides along the Asian jet and over northern Eurasia. Empirical orthogonal function (EOF) analysis to the low-frequency (10-day low-pass filtered) variation during summer reveals wave-propagation patterns on both of the waveguides. The time evolution of the two composite fields, constructed using the obtained EOF modes for each phase of the seesaw mode, was investigated by the wave-activity flux. In both composite fields, eastward-propagating Rossby waves originating from the North Atlantic–European sector branch off around eastern Europe onto the two waveguides, which become out of phase toward the east because of the difference in longitudinal wavelengths along them. This results in opposite phase anomalies of meridional winds over northeast Asia and Siberia. Budget ...


Microrheological parameters of red blood cells (RBCs) and blood viscosity were studied by different optical and rheometric techniques. Measurements were performed under in vitro condition both on the EDTA-stabilized whole blood samples at various temperatures and on the RBCs in autologous serum without platelets at different concentrations of proaggregant macromolecules (Dextran 150, Dextran 500 and albumin). The nonlinear dependences of the aggregation parameters on the concentration of the proaggregant macromolecules in autologous serum were observed. Rheometry of human whole blood samples demonstrates a power law dependence of the suspension viscosity on temperature at such shear rates that allow the RBC aggregation. We assume that there may be an unaccounted temperature dependent synergetic effect of plasma proteins/macromolecules on RBC aggregation and interaction and, consequently, on the blood viscosity.


The availability of automatic tools for inferring semantics from database schemes is very relevant in designing large cooperative information system applications involving many information sources. Deriving semantics from existing data sources exploits properties of objects belonging to different input schemes (interscheme properties), such as synonymies, homonymies, type conflicts, and subscheme similarities. The paper gives a contribution in this context by proposing a collection of graph based techniques for a uniform derivation of all interscheme properties. All techniques are characterized by a common core consisting of the computation of a maximum weight matching on suitable bipartite graphs. The computation of the maximum weight matching is based on a suitable metrics which is used to measure object semantic similarities. A running example is provided to illustrate the approach.


Thickness checking is one of the quality control procedures in the brake pad industry. This research aims to address the issue of the time effectiveness of the thickness checking by turning the technique into an automatic process, from specimen preparation to data recordings; the technical aspects, the geometric design, and the structure analysis are critical elements of the industrial machinery. However, economic analysis is considered when it becomes an investment by a company with long-term use expectations. Thus, this research provides structural analysis, time checking estimation, and simple investment feasibility studies on break-even points and a simple payback period to ensure that the new design can improve testing performance. Monte Carlo simulation offers the calculation of investment feasibility with the three possibilities of pessimistic, optimistic, and realistic results in achieving a break-even point (BEP) and a simple payback period.


T webbed concrete members, such as single and double T beams, are commonly used in prestressed concrete construction. As in the case of other flexural members, these beams need to be reinforced with an appropriate amount of shear reinforcement to control diagonal tension cracking and to prevent shear failure. However, since these members have narrow webs, the use of conventional closed loop stirrups is inconvenient and uneconomical. In such members, the use of welded wire fabric appears to provide an economical alternative, and is being increasingly used by the prestressed concrete industry. This issue was studied by the joint PCl/WRI Ad Hoe Committee on Welded Wire Fabric for Shear Reinforcement.' On the basis of their recommendations, the relevant ACI Code 2 provisions were revised to allow for the use of plane sheets of welded wire fabric with two horizontal wires as


SIR Recently the Geological Society has published two memoirs written by the lately lamented doyen of British palaeogeographers (Wills, 1973, 1978). The maps which they describe were compiled to provoke discussion concerning the nature and extent of the Palaeozoic rocks concealed below younger rocks in central and southern England. The purpose of this note is to strengthen the data on which the maps are based in two places; (1) by challenging the inference that Cambrian has yet been proved at Fobbing in south Essex (Wills, 1978, pi. 2, locality 13 A, pp. 29,34) and (2) by supplying faunal documentation for the inference of Upper Devonian at, or rather near, Chislet Colliery, Kent (Wills, 1978, pi. 1, Chislet c3). In the 1940s, I was one of those to whom G. M. Lees submitted for comment his MS speculative map of the sub-Mesozoic incrops in southeast England. I used that opportunity to re-examirie in the Geological Survey collections, the fossil fragments which J. Pringle had recovered from very small shale chippings found at a depth of 1127-1153 ft below Gault in a borehole at Fobbing (Pringle, 1925, p. 134). Cleaning these fragments of some matrix revealed that Pringle's identification of Acrotreta (and thus a Cambrian age) could not be substantiated because one fragment was of a palaeoniscid fish scale. This, numbered Pe 2200, I submitted to Dr E. I. White who confirmed my palaeoniscid identification and possible Carboniferous assignment, and added that the age was unlikely to be older than Middle Devonian. I passed this information to Lees who made two brief references to it (Lees & Taitt, 1944, p. 16; Lees, 1946, p. 6). On the earlier of Wills's maps (1973, pi. 1) the Palaeozoic rocks at Fobbing are classed as 'ORS(M. Dev.)' and the same stratal allocation is repeated on Plate 1 of the 1978 publication. The 1944 reassessment of the age of the Fobbing Palaeozoic contributed to the Geological Survey decision to commission the 1953 Canvey Island Borehole (Edmunds, 1954, p. 29). Reference to Chislet, Kent, recalls that H. G. Dines (1933, pp. 29, 30) commented on the paucity of geological information concerning the age of strata encountered in some of the 1912-14 boreholes fringing the northern part of the Kent Coalfield. During visits to Chislet Colliery to examine cores from then current underground boreholes in the early 1940s, I enquired concerning the whereabouts of any cores from these 1912-14 boreholes and in November 1944, a colliery surveyor showed me a footpath in the colliery yard made up of cores which he told me came from the 1912 Chitty, Chislet Park and Rushbourne boreholes. Amongst these was a four or five-inch core length of grey-green calcareous shale, 5£ inches in diameter. In this I found a shelly mass composed mainly of large, undistorted A try pa reticularis (Linnaeus) and occasional Cyrtospirifer cf. verneuillii (Murchison); one of the latter (CS 1729) recalled a similar shell from the Upper Devonian of Wolborough, Devon. Efforts to relate this core to such borers' records as were available proved inconclusive though I had a hunch that the core might have come from Rushbourne; other cores of different diameter yielded earlier Devonian fossils.


Oxidative stress is implicated in obesity and obesity‐hypertension, but most studies have focused on peripheral adipose and cardiovascular tissues. Recently, a role for brain NADPH oxidase (Nox) has begun to emerge in DIO. We tested the hypothesis that Nox activity in the PVN, a key energy and cardiovascular homeostasis center of the brain, is causally linked to DIO. Mice harboring a floxed allele of p22phox, the required subunit for Nox assembly and activity, underwent bilateral PVN‐targeted injection of an adenovirus encoding Cre recombinase (AdCre) to delete PVN p22phox or control red fluorescent protein (AdRFP). After recovery, mice were fed high fat diet (HFD, 42%) for 8 weeks. Ablation of p22phox in the PVN with AdCre blunted HFD‐induced increases in body weight compared to AdRFP‐injected mice (AdRFP: +11.46±0.49g vs AdCre: +6.9±0.57g, n = 3, p<0.05). Real‐time qPCR confirmed p22phox deletion in PVN. Since Nox is functionally linked to endoplasmic reticulum (ER) stress pathways in some cell types, we examined the effect of deleting p22phox on ER stress biomarkers in PVN of these mice. Preliminary data show that mice with PVN‐targeted ablation of p22phox have lower levels of HFD‐induced GRP78 (−68%, n=2) and GRP94 (−38%, n=2) mRNA in this brain region compared to controls. These data suggest that oxidative and ER stress in the PVN contribute to diet‐induced obesity. HL063887, HL084207


The output torque capability of the AC motors can be enhanced by utilizing the overmodulation region of the inverter. In this case, the output torque capability depends on the overmodulation methods used. The steady-state overmodulation methods are generally used for operating up to six-step mode of the inverter, but they are not easy to implement and produce a slow dynamic torque response. On the other hand, the dynamic overmodulation methods are easy to implement and can produce a fast dynamic torque response, but the voltage gain of the inverter in the overmodulation region becomes nonlinearly smaller than one. Hence, it becomes difficult to operate the inverter up to the six-step mode with this method. This paper proposes a scheme that can increase the voltage gain for the dynamic overmodulation methods. By using the dynamic overmodulation methods with the proposed scheme, the inverter can operate up to the six-step mode and give a fast dynamic torque response during the flux-weakening operation. As a result, the output torque capability can be enhanced effectively in the high-speed operation. Through simulations and experiments, it was verified that the proposed scheme can be applied to the DPWM (Discontinuous Pulse Width Modulation) methods as well as the continuous PWM methods.


Summary The determination of topographical macro-velocity model is of great significance for seismic imaging in the mountainous or piedmont area, such as West and South China. Therefore, an effective procedure for migration velocity analysis on topography is needed. The residual curvature analysis (RCA) based on the CIGs is an effective method to improve the accuracy of the topographical macro-velocity model. Based on the offset CIGs generated by rugged topography Kirchhoff PSDM, we propose a complete depth migration velocity analysis workflow which includes the conversion of average velocity to interval velocity and the updating of rugged topography migration velocity model. Numerical tests on Field data from mountainous area reveal the effectiveness of this workflow.


Taking vacuum freeze-drying time and rehydration rate as main index,effects of ultrasonic pre-processing on banana slice was explored in this paper.Results showed that ultrasonic pre-processing can short the vaccum freeze-drying time and improve rehydration rate of product,the optimal conditions of ultrasonic pre-processing are as follows: ultrasonic power 140 W,processing time 30 min,ultrasonic frequency 28 kHz.Under this condition,the whole vaccum freeze-drying time was 8.9 h.


Integrated nanopore sensors enable label-free electrical detection of single molecular biomarkers using modulations in ionic current across a nanoscale opening in a solid-state membrane. Optical trapping can dramatically increase the rate of molecular detection and, thus, significantly speed up the sensing process. This is accomplished by optical delivery of microbeads that carry molecular targets that are specifically bound to their surface. Once trapped at the nanopore location, targets are released from the carrier bead and drawn through the pore by the large electric field that is present right at the pore location. We review the principle and implementation of this approach on an optofluidic chip. We report over 1000x improvement in sensing time and the application of these devices to detection of different molecular biomarkers and for infectious disease diagnosis of clinical samples.


INTRODUCTION:Febrile seizures are the most common form of childhood seizures, occurring in 2 to 5% of children. The peak incidence is at the age of approximately 18 months, with recurrent episodes occurring in one third of patients. Iron deficiency is the most common nutritional disorder affecting at least one third of world's  especially between 6 and 24 months, this study was taken up to determine the association between febrile seizures and Iron deficiency as defined by the hematological parameters, which is a very important  investigation in a resource limited country like India. AIMS: Prospective study to determine the association between iron deficiency anemia and febrile seizures in the age group 6 to 60 months. METHODS AND MATERIALS: study design c ase control study. Study period :7 months period from March 2014 to September 2014 Children of age group 6 months to 60 months presenting with febrile seizures to the pediatric emergency department and wards of the hospital were included  RESULTS: 80% of the study population within seizure group was between 6 months and 36 months. There was no significant gender predisposition for febrile seizures, and both genders were affected more or less in equal proportion.Family history of febrile seizures was a significant non modifiable risk factor in the seizure group. 21.4% of seizure group had a family history of febrile seizures in first degree relatives. There was a significant difference in the value of Hb, MCH, serum iron, TIBC and RDW among the seizure group as compared to control group. There was a mean difference of 5% of MCV between the seizure group and controls, which was not statistically significant in the study. CONCLUSION: Hematological parameters have been demonstrated to be sensitive and specific in children, and stable in the presence of febrile illness. Complete Blood count, being a simple and feasible investigation, can be used to screen individuals with iron deficiency in simple febrile seizures, for making a decision to start iron supplementation.


Objective To study the expression of TMEM135 mRNA and protein in a variety of normal and tumor tissues. Methods We used in situ RT-PCR and immunohistochemistry to detect the expression of TMEM135 mRNA and protein in 118 cases of normal tissues,18 cases of benign and 55 cases of malignant tissues. Results TMEM135 mRNA and protein expressed widely in the human tissues. TMEM135 mRNA mainly distributed in the nuclear membrane and the protein was mainly in the cytoplasm which was mostly grainy distributed. There was significant difference in the expression of TMEM135 protein between normal and cancer tissues. Conclusion TMEM135 might be a protein which is associated with the tumor.


This paper presents an axial-flux machine with hybrid excitation (HE), in which the flux linkage can be regulated in an extremely wide range by using a rotating excitation winding. This machine shows a theoretically infinite constant power speed range and also exhibits a high degree of fault tolerance against uncontrolled generator operation. The machine has a single-stator double-rotor topology, with one rotor mounting permanent magnets and the other supporting the excitation winding. After a review of the state of the art of HE machines, this paper examines the principle of operation of this machine. Subsequently, a prototype is designed, analyzed with finite-element analysis, and built. Finally, experimental results are reported to confirm the theoretical predictions and the benefits and drawbacks of this novel topology.


As a wave of babyboomers retire, the upcoming decade will see only a modest expansion in Manitoba's available workforce, and most of this net increase will depend on job-seeking young Aboriginals. Policy reforms should encourage more Aboriginal students to finish high school. Smart reforms to financial aid for postsecondary education would demonstrate aid availability to students early in their academic careers. This would bolster student educational aspirations during secondary studies for those on the margins of accessing postsecondary education. With large numbers of Aboriginal high-school dropouts, Manitoba cannot, and should not, rely solely on expanding international immigration to boost workforce growth.


In this paper,we proceed the video collection by Video for Windows(VFW) this software development pack,after compression and packed,the video data will be transferred into another port,the received data will be compressed,played finally.


The P2X7 receptor is an ATP‐gated cation channel expressed in immune cells and plays a role in proinflammatory cytokine release from monocytes and macrophages. This study investigated the coinheritance of 12 functionally relevant single nucleotide polymorphisms (SNPs) in the human P2X7 gene (P2RX7), and the functional effect of each singly and in combination was assessed by measurements of ATP‐induced currents and ethidium+ uptake. Genotyping of 3430 Caucasian subjects identified 4 common haplotypes in addition to the common (wild‐type) P2X7‐1. Two haplotypes (denoted P2X7‐2 and P2X7‐4) contained various combinations of gain‐of‐function SNPs. P2X7‐4 was identified uniquely by the Gln‐460 to Arg polymorphism (rs2230912). When expressed in HEK‐293 cells, recombinant P2X7‐2, and P2X7‐4 haplotypes displayed a 3‐fold and 5‐fold increase, respectively, in receptor function compared to the wildtype P2X7‐1. Both P2X7 haplotypes contained the Ala‐348>Thr polymorphism (rs1718119), and this mutation was critical for the gain‐of‐function effect. Peripheral blood monocytes and erythrocytes from subjects homozygous for gain‐of‐function P2X7 haplotypes exhibited increased ATP‐induced ethidium+ uptake and 86Rb+ efflux, respectively, and this correlated with increased IL‐1β secretion from LPS‐primed monocytes. Inheritance of these P2X7 haplotypes predisposing to increased proinflammatory cytokine secretion may be important in genetic association studies of inflammatory, infectious, and psychiatric disorders.—Stokes, L., Fuller, S. J., Sluyter, R., Skarratt, K. K., Gu, B. J., Wiley, J. S. Two haplotypes of the P2X7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion. FASEB J. 24, 2916–2927 (2010). www.fasebj.org