The paper uses sports participation data from the General Household Survey to examine shifts towards more individualized, flexibly timed, fitness-oriented activities. It examines various (often critical) theoretical explanations for these changes in the nature of sports participation- postmodernism, post-Fordism, feminism, time squeeze, increased access to further education- and suggests that policies aimed at sports development need to take account of wider social, economic and cultural influences. It seeks to explore the hypothesis that policy makers, depending on their objectives, might be better to 'flow with the flow' than try to 'buck the trends' of patterns of sports participation.


Apraxias and the loss of evocation and development of the gesture are one of the most important problems in the re-education of the stroke patient. The rehabilitation of upper functions only can be carried out if the causes of the dysfunctions are known; so a treatment plan according to these neuropsychological alterations can be designed. It is necessary to know with precision which aspect we must re-educate and distinguish between symptoms and pathology. The treatment is based on the application of basic principles which would make possible a better organization in the space, a better gesture activity and better personal relationships. All these factors have to be placed in a project that must be realistic and aim at independence in activities of daily living.


This thesis concerns the notion of functionality in European trademark law and in particular how the absolute ground of refusal for signs that exclusively consist of a shape which gives substantial value to the goods is applied in relation to signs consisting of the shape of products. The current law relating to shape of product marks is described both as regards technically functional signs and signs which confer substantial value to the goods. The underlying rationale and application of the provision on aesthetic functionality are discussed with references to technical functionality where appropriate. The two major rationales that determine the application and interpretation of these provisions are found to be the prevention of cumulative rights and the protection of efficient competition. The application deals with the provision's nature as a prior obstacle that needs to be taken into account of the beginning of an assessment of the sign, finding the function to be a rational one. It further discusses the essential characteristics of a sign, the meaning of the exclusively criterion and the Courts' identification procedure in the Lego Juris case. Also, the notion of substantial value and what that criterion entails is discussed separately and the conclusion is drawn that the most reasonable interpretation is that it is negatively defined by the protection requirement of individual character in design law. As such, an examination of the protection requirements of design law is made, describing especially the criteria of 'informed user', 'overall impression' and 'design freedom'. Subsequently an analysis is made, resulting in the opinion that the protection of shape of product marks under the European system is not only difficult but also carries with it a large amount of legal uncertainty. Finally, a theoretical test based on the notion of recognition is presented as an attempt to inject some structure into the system. (Less)


Content distribution in network may be vulnerable henceforth unauthorized users can inject "bogus" data to corrupt the content during its distribution process in order to deplete the network resource. Content verification is the important one to maintain integrity of the content. This is achieved by on the fly verification. Content is splitted and hashing is applied. Hashed content is sent to the destination through peer to peer network. Key is sent to the destination directly from the source. Without the key unauthorized users finds difficult to modify the content.


The free-surface boundary conditions are persistent problem in elastic wave equation modeling by finite-difference method, which can be summarized with the degradation of the accuracy of the solution and limited stability range in Poisson's ratio. In this paper, we propose the mid-point averaging scheme as an alternative way of implementing the free-surface boundary conditions, and present the solution to Lamb's problem to verify our approach.


Currently, Linux operating system has become a research focus in the embedded system field, due to its unique advantages such as open-source and security. In this case, this paper provides an idea to transplant the navigation program from VxWorks system to Linux operating system. Therefore, in order to achieve the objective mentioned above, this paper focuses on the analysis of startup process of Linux and kernel based on x86 platform. Then, the key techniques will be resolved to establish a complete development environment and construct an embedded Linux operating system to meet application requirements. In this paper, the method taking advantages of Clonezilla is recommended to backup and restore the embedded Linux.


A physics-based degradation rate (DR) model is discussed which can effectively predict TDDB degradation at low failure rates. The model is shown to follow all the features of TDDB degradation-like Weibull distribution, area scaling etc. In addition, a self-consistent statistical learning model is proposed which can predict TDDB degradation with same accuracy of DR model albeit without the need for large amount of data collection. Both models are shown to accurately predict TDDB degradation for low failure rates (∼ 1 ppm) which makes them extremely effective tools for time-to-failure estimations for technology qualifications especially for automotive applications.


Despite some empirical findings on the usefulness of citizen's charters on awareness of rights and services, there is a dearth of literature about charter implementation and impact on health service delivery in low‐income settings.


9. I can select materials which the student will carry into his normal activities. 10. I can select teaching materials that have a strong social element. 11. I can arrange the activities which are suggested in such a manner that there will be many types of activities, ranging from the very simple concrete activity to the abstract. 12. I can arrange the material in such a manner that each succeeding problem will make growth possible, using materials previously obtained as skills or habits or attitudes. 13. I can arrange the problems so that each one leads to the achievement, by the pupil, of desirable attitudes, skills, interests, habits, and appreciations. 14. I can arrange materials so that each problem provides for cooperative practice. 15. I can arrange the problem in such a manner that the pupil will be enabled to practice integrity, with sufficient guidance to keep him from practicing dishonesty. 16. I can provide for the pupil to have opportunity to use all of the initiative which he possesses, and to develop more. 17. I can place on the student all of the responsibility which he will be able to discharge, and I can provide sufficient guidance to see that he does not assume more than he can answer for. 18. I can provide opportunities for the exploration of a rich culture.


S. Pearson & Son, forerunner to the present-day Pearsons PLC, started as a general works contractor in the 1860s and emerged as a global enterprise mainly on the strength of public works contracts undertaken for the Mexican government between 1889 and 1906. This article looks at how this business operated, analysing the capital flows through the contracts. These involved substantial quantities of public debt, mostly in the form of silver bonds. The very favourable terms achieved by Pearson and the fact that he built all the largest public works projects, suggest that he enjoyed a virtual monopoly over this kind of contract in Mexico. Some explanations of this are examined, together with their possible implications regarding technology transfers and modelling the future development of the Mexican construction industry.


With a non-cooperative bargaining model, this paper researches the forming mechanism of urban unemployment when state-owned enterprise (SOE) is prohibited from hiring rural labor and when it is not. Comparison between this two circumstances shows that once the artificial limits on rural labor's employment in city are loosened, wage will get down to the level as a competitive labor market, and the number of urban unemployment tend to decrease in a long term. Therefore, some cities' usual policies for urban labor market against rural labor lead to more urban unemployment rather than less. This paper also proves the unemployment characteristics of classical model in transitional China.


the sentence "just women and mean persons are difficult to get along with(唯女子与小人为难养)" from Lunyu is always thought to be the evidence that Conficius despise women.However,there are ninteen words "女" in Lunyu,in which there are eighteen "女" mean you or your except one "女" means woman.Actually "女子" should be explained as your son(s)."难养" means to be difficult to cultivate.Thus the whole sentence should be explained as only your son(s) and mean persons are difficult to cultivate,moreover,Conficius didnit despise women.


 16 states have laws requiring districts to consider a teacher's rating on a performance evaluation in making a decision about whether to grant tenure: Alaska, Colorado, Connecticut, Delaware, Florida, Illinois, Indiana, Louisiana, Michigan, Nevada, New Jersey, Oklahoma, Rhode Island, Tennessee, Washington and Wyoming.  Seven states require districts to return non-probationary teachers to probationary status if they are rated "ineffective." This means these teachers lose the assurance that their contract will be renewed at the end of the school year. The seven states are Arizona, Colorado, Idaho, Indiana, Louisiana, Nevada and Tennessee.


Abstract The problem of oscillations detection for nonlinear systems is addressed. The notion of homogeneity in bi-limit from (Andrieu, et al., 2008) is extended to local homogeneity. Next, sufficient conditions of oscillations existence for locally homogeneous systems are formulated. The proposed approach allows one to estimate the number of limit cycles and the regions of their location. Efficiency of the technique is demonstrated on two academic examples.


Analysis of the literature data indicates the great attention of specialists to the formation of ultrafine-grained (UFG) and nanocrystalline (NC) structures. Such structures are obtained by severe plastic deformation and other methods to improve the bulk properties of materials. Improving the properties of the surface layers of materials is achieved by modifying them with the formation of NC structures by different methods. In the article, in the development of earlier work, the results of studies of the formation of such structures by the method of electrospark alloying (ESD) are reflected. The aim of this work was to obtain experimentally quantitative data on the nanostructuring of electric-spark (ES) coatings, specifying the effect of the technological parameters of ESD and electrode material on this process. The studies included the determination of the energy parameters of the ESD process, changes in the mass of samples to obtain pulsed values, as well as the grain size of the structure of ES coatings. At the same time, modern certified technological and research equipment and recognized methods were used. The studies were carried out in a wide technological range: pulse energy E = 0.045...0.29 J, their duration timp = 20...80 μs, frequency fimp = 300...1500 Hz, the conditional value of the specific processing time tsp = τ...5τ. The result of the work is the following: coatings are obtained with a content of 5 to 50 % of the granular structure of the nanoscale level using electrodes made of hard alloys VK8 (92WC + 8Co) and STIM-3BOAn (72TiC +17.5Cr3C2 +10Ni + 0.5Al2O3 nano); it was found that an increase in the pulse energy leads to an increase in the grain size of the nanoscale level and a decrease in their fraction in the coating, and an increase in the pulse frequency and specific ESD time, on the contrary, to a decrease in the grain size and an increase in their number; the use of anode materials with a refractory nanocomponent also contributes to the nanostructuring of ES coatings. In developing this topic, attention is drawn to one of the important issues requiring separate studies — this is the study of the role and efficiency of pulses of the low-energy zone of electric regimes in the process of nanostructure of ES coatings.


Generalized Coordinates Synthesis (GCS) method is a convenient approach to predict wind-induced responses of buildings and structures based on the wind pressure time histories obtained by wind tunnel tests. Unlike traditional ways in frequency domain, GCS method calculates the wind-induced responses in time domain. The wind pressure time histories are firstly transformed into modal forces by matrix multiplication and consequently the single-degree-of-freedom generalized coordinate equations are solved readily by Fast Fourier Transform in frequency domain. Finally the responses can be obtained by the mode superposition. GCS method generally takes less than 10% of time consuming of traditional methods while the results are mathematically equivalent with them. In addition, further applications can be developed easily since the time histories of modal forces have been explicitly given using GCS.


In this paper, we estimate GARCH, EGARCH, and GJR-GARCH models assuming normal and heavy-tailed distribution (i.e., GED). Results suggest that when the heavy-tailed distribution is considered, the persistence has found to be reduced in all the cases. Findings also reveal that positive shocks are more common than the negative shocks in this market.


Amylomaltase, or 4‐α‐glucanotransferase (EC 22.214.171.124), is involved in glycogen and maltooligosaccharide metabolism in microorganisms, catalyzing both the hydrolysis and transfer of an α‐1,4‐oligosacchraride to other sugar molecules. In this study, we determined the crystal structure of amylomaltase from Thermus brockianus at a resolution of 2.3 Å and conducted a biochemical study to understand the detailed mechanism for its activity. Careful comparison with previous amylomaltase structures showed a pattern of conformational flexibility in the 250s loop with higher B‐factor. Amylomaltase from T. brockianus exhibited a high transglycosylation factor for glucose and a lower value for maltose. Mutation of Gln256 resulted in increased Km for maltotriose and a sharp decrease of the transglycosylation factor for maltose, suggesting the involvement of Gln 256 in substrate binding between subsites +1 and +2. Mutation of Phe251 resulted in significantly lower glucose production but increased maltose production from maltopentose substrates, showing an altered substrate‐binding affinity. The mutational data suggest the conformational flexibility of the loop may be involved in substrate binding in the GH77 family. Here, we present an action model of the 250s loop providing the molecular basis for the involvement of residues Phe251, Gln256, and Trp258 in the hydrolysis and transglycosylation activities in amylomaltase. Proteins 2011. © 2010 Wiley‐Liss, Inc.


An introduction to antiferroelectric phases and their properties is given, before describing in detail the effects of polymer stabilization on this phase, which is a contender to ferroelectric liquid crystals in displays and optical light shutters. The effects of polymer stabilization under various different applied electric field conditions, and the resulting electro-optic behavior is summarized and demonstrated, as are the effects on a variety of important material parameters. With respect to applications, the generation of grayscale responses from electric addressing field sequences is discussed.


The proximity effect between a ferromagnet and a superconductor is examined within the framework of the self-consistent Bogoliubov de Gennes equations. It is shown that for a thin ferromagnetic layer on a semi-infinite superconductor, a spontaneous supercurrent may flow parallel to the interface. The current turns on or off repeatedly as a function of the exchange splitting, Eex for a fixed thickness film, d. It is shown that the current state is stabilized by a lowering of the total quasiparticle kinetic energy, and this is interpreted in terms of the Andreev bound states in the ferromagnetic layer.


Chronic graft-versus-host disease (GVHD) occurs in 20% to 40% of long-term survivors of allogeneic bone marrow transplantation.' The overall clinical picture resembles scleroderma with involvement of the skin, liver, eyes, mouth, upper respiratory tract, and esophagus.' Oral chronic GVHD causes lichenoid stomatitis and sialadenitis with sialodochitis, resulting in decreased or absent salivary IgA and inorganic phosphate secretion; decreased salivary flow rates; and increased concentrations of salivary sodium, albumin, and IgG.3 Xerostomia because of decreased salivary flow results in oral pain, discomfort, canes, repeated infections, and difficulty in eating and speaking, and is a major cause of morbidity in patients with chronic GVHD.3 The xerostomia is often persistent despite systemic immunosuppression and improvement of GVHD elsewhere. Artificial saliva relieves the symptoms to a limited extent, and its acceptability is low. Pilocarpine hydrochloride is a parasympathomimetic agent with predominantly muscarinic activity that stimulates secretion of mucin, proteins, glycoproteins, and electrolytes in the saliva. Oral administration of pilocarpine has been shown to improve saliva production and relieve the symptoms of postirradiation xerostomia in patients with head and neck ~ a n c e r . ~ We have treated five patients with xerostomia caused by chronic GVHD with the ophthalmic preparation of pilocarpine administered orally at the dose of 5 mg three times a day. Oral GVHD was diagnosed on the basis of the typical clinical findings of mucosal atrophy, erythema, or lichenoid mucosal lesions and pain.' Four patients had received total body irradiation as part of the conditioning regimen for the allograft, but none had noticed xerostomia before the onset of chronic GVHD. All patients had found artificial saliva to be unsatisfactory in relieving their symptoms. Previous or concomitant immunosuppressive therapy was unsuccessful in relieving xerostomia in all patients and  included cyclosporine, corticosteroids, azathioprine, thalidomide, and psoralen-UV irradiation in various combinations. The intensity of concomitant immunosuppression was either unchanged or decreased during pilocarpine therapy. As shown in Table I , four of five patients noticed significant improvement in salivary flow and relief of symptoms. Furthermore, increased salivation had a beneficial effect on the oral mucosa and dental hygiene. The time for benefit to be noticed (7 to 45 days) and the time to maximum benefit (7 to 186 days) were widely variable. Patients no. 1 , 4, and 5 had xerophthalmia as well, but improvement was noticed only by patient no. 1 . Adverse effects were infrequent, transient, and acceptable and led to discontinuation of the drug in only one patient (patient no. I ) . The drug was stopped electively in patient no. 2, a heavy smoker,


To provide a tantalum and pellets intended for the niobium electrolytic capacitor configured with powder of either. Do not contain A porous oxygen, and thermal annealing process, a doping process pellets with nitrogen, these properties both can be implemented in an oxygen-free environment. Method for producing pellets, powders select tantalum, from one of niobium, a powder molding the self-contained pellets were press-molded, to remove oxygen pellets, after annealing the pellets, nitrogen into pellets comprising the step of lowering the DLC diffused doped with nitrogen into pellets. These steps are carried out in all oxygen-free environment.


This work focuses on the effects of vegetation on a fluid flow pattern. In this numerical research, we verify the applicability of a simpler turbulence model than the commonly used k-" model to predict the mean flow through vegetation. The novel characteristic of this turbulence model is that the horizontal mixing-length is explicitly calculated and coupled with a multi-layer approach for the vertical mixing-length, within a general three-dimensional eddy-viscosity formulation. This mixing-length turbulence model has been validated in previous works for different kinds of non-vegetated flows. The hydrodynamic numerical model used for simulations is based on the Reynolds-averaged Navier–Stokes equations for shallow water flows, where a vegetation shear stress term is considered to reproduce the effects of drag forces on flow. A second-order approximation is used for spatial discretization and a semi-implicit Lagrangian–Eulerian scheme is used for time discretization. In order to validate the numerical results, we compare them against experimental data reported in the literature. The comparisons are carried out for two cases of study: submerged vegetation and submerged and emergent vegetation, both within an open channel flow.


Despite of the intensive studies, Colossal Magnetoresistance (CMR) phenomena occurring in manganese oxides is still not fully understood. Theoretical studies based on an ordered crystal phase such as the charge-ordering (CO) phase have shown some successes in reproducing experimental evidences. Recently it was, however, shown that such a CO phase included giant clusters which were as large as 100 nm. This indicates the importance of the nanometer-scale information about the electronic structure to understand the CO. La0.5Sr1.5MnO4 is one of the oxides under intense investigations. in the CO phase, the eg valence electrons were found to be ordered at Mn sites. The optical responses of the CO clusters, however, has not been studied. in this study we have attempted to obtain such information from CO clusters in La0.5Sr1.5MnO4 by angular-resolved electron-energy-loss-spectroscopy (EELS) using an in-column type Ω-spectrometer.


Purpose – The purpose of this paper is to describe project‐based companies' knowledge production and memory development with the help of autopoietic epistemology.Design/methodology/approach – The discussion first defines the concept of a project‐based company. Then the discussion deals with the two epistemological assumptions, namely cognitivist and autopoietic epistemological assumptions. After that there follows an illustration of the concept of organisational memory. The main content of this article follows – namely the study on the autopoietic knowledge production and organisational memory development in the context of project‐based companies.Findings – Knowledge production in a project‐based company means that an individual team member, a project team and a project‐based company itself produce knowledge consistent with currently shared knowledge. That is, a project‐based company's accumulation of organisational memory at various organisational levels is an expression of change in knowledge that alway...


It is necessary to conquer the path dependence on the successful development model in the early stage in order to assure the continuous growth of new venture.With the development of new venture,the key task and main problems of new venture would take on dynamic evolvement characteristics,which make the founder role of new venture put up dynamics.During the different seedtime of new venture,the founder should adjust the role orientation to conform to the changing requirements of new venture's development.


Bamboo is just another grass with an endless list of uses. Bamboo shoot contains a cyanogenic glycoside 'amygdalin' composed of glucose, benzaldehyde and cyanide. We present a case of a 14 year old female patient with history of consumption of bamboo shoot extract (juice) who was brought in an unconscious state and admitted to the Department of Medicine in our hospital. She was treated symptomatically with supportive therapy after conducting relevant laboratory investigations. The patient recovered consciousness after 2 days and was discharged after 10 days of admission.


The paper examines to what extent the policies of the United States and West European countries and international organisations affect ethno-confessional segmentation, political attitudes of religious leaders and institutions and contribute to the goal of stabilisation and peaceful reintegration of the successor states of former Yugoslavia to Europe and the wider world, which most of them purport to achieve. It does so by three-tier level analysis into: 1) Symbolic promotion of religious leadership; 2) Political, legal and financial involvement and policies; 3) Fostering interfaith dialogue and reconciliation.


The proposed algorithm introduces three parameters, i.e. fit_(max), fit_(min), and fit_(ave) to measure how close the individuals are. Furthermore, the elitist strategy is employed to protect the best individual of each generation, and remainder stochastic sampling with replacement (RSSR) is employed in the proposed IAGA to improve the basic reproduction operator. By determining p_c and p_m of the whole generation adaptively, it strikes a good result. Segmentation of fingerprint images can not only compress the information of fingerprint images and hold the main information of ridges and valleys, but also remove an amount of conglutination among ridges and valleys and improve the performance of the feature extraction and matching of fingerprint images. In this paper, the segmentation algorithm of fingerprint images based on the improved adaptive genetic algorithm and directional image method is presented.


The fast and mechanical life with dust and pollution of today's era has kept the man away from the normal regimen for sound health which ultimately gives rise to various diseases. The role of medicine become in effective continuous use of medicines. Even the modern medicine has recognized the important role but now Ayurvedic medicines has very effective.


ARPA : email@example.com v 1. INTRODUCTIO N SAIL (1,2) is an easy to use block-structured compiler dialect of the ALGOL-60 programming language . It has been used successfully in writing many large application programs because it has sufficen t expressivity and efficiency as well as languagètools' which help control complexity. It has several powerful language extensions (over basic ALGOL) one of which is the LEAP associative sublanguage (2-4) and dynamic strings. I will attempt to convey some of the flavor and power of SAIL in this tutorial whic h draws upon the reader ' s familiarity with C and Pascal-like languages. If you know Pascal then you almost know SAIL. It is a large language with about 300 keywords compared with C ' s 30 (not counting th e C runtime library which is of comparable size). However, SAIL may be divided into much smaller independent sublanguages which are not that difficult to master. SAIL was written in assembly language at Stanford University Artificial Intelligence Laboratory t o run only on DECsystem-10 and-20 computers. To get around this problem, a portable recursive descen t SAIL compiler called PSAIL (5) has been written. PSAIL translates a large useful subset of SAIL into a portable subset of C (6,7). Using PSAIL as a preprocessor, C code can be generated for different levels o f runtime support. Although a preprocessor increases the cycle time of an edit-compile-link-run-edit loop , using small modules can keep the this time within acceptable bounds. Full PSAIL runtime support includes C runtime functions to support dynamic arrays, dynamic strings with string garbage collection an d emulation of many SAIL built-in functions. Alternatively, PSAIL can generate C code without PSAI L runtime support. The code can then be edited lightly to run with a target system ' s C runtime library. After giving an overview of the relationship of PSAIL to the SAIL language, they will be introduced with a short tutorial. PSAIL ' s construction was motivated by need. I had written a large system called GELLAB (8) fo r the statistical analysis of 2D electrophoretic protein gel images. This system consists of SAIL applicatio n programs performing data acquisition, image processing, disk-based data base management, statistica l analysis and graphics. When Digital Equipment Corporation announced the demise of the DECsystem-10/-20 series computers, these programs needed to be translated to other machines. Hand translation using a text editor …


The optical properties of silicon have been determined from 0.2 to 6.5 eV at room temperature, using reflectance spectra of silicon-on-insulator (SOI) and ellipsometric spectra of homoepitaxial samples. Optimized Fabry-Perot-type SOI resonators exhibit high finesse even in near ultraviolet. Very high precision values of the real part of the refractive index are obtained in infrared up to a photon energy of 1.3 eV. The spectra of the extinction coefficient, based on observations of light attenuation, extend to 3.2 eV due to measurements on SOI layers as thin as 87 nm. These results allowed us to correct spectroellipsometric data on homoepitaxial samples for the presence of reduced and stabilized surface layers.


e21138 Background: Alectinib is standard of care for metastatic anaplastic lymphoma kinase positive (ALK+) nonsmall cell lung cancer (NSCLC). Weight gain is an unexplored side effect reported in ~10%. To prevent or intervene alectinib-induced weight gain, more insight in its extent and etiology is needed. Methods: Change in body composition was analyzed in a prospective series of 46 patients with ALK+ NSCLC, treated with alectinib. Waist circumference, skeletal muscle (SM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) were quantified using sliceOmatic software on computed tomography (CT) images at baseline, three months (3M) and one year (1Y). To investigate an exposure-toxicity relationship, alectinib plasma concentrations were quantified. Four patients with > 10 kg weight gain were referred to Erasmus MC Obesity Center for in-depth analysis (dietary habits, metabolic/endocrine assessment). Results: Mean increase in waist circumference was 9 cm (9.7%, p < 0.001) in 1Y with a 40% increase in abdominal obesity (p = 0.014). VAT increased 10.8 cm2 (15.0%, p = 0.003) in 3M and 35.7 cm2 (39.0%, p < 0.001) in 1Y. SAT increased 18.8 cm2 (12.4%, p < 0.001) in 3M and 45.4 cm2 (33.3%, p < 0.001) in 1Y. The incidence of sarcopenic obesity increased from 23.7% to 47.4% during 1Y of treatment. Baseline waist circumference was a positive predictor of increase in VAT (p = 0.037). No exposure-toxicity relationship was found. In-depth analysis showed increased appetite in two patients and metabolic syndrome in all four patients. Conclusions: Alectinib caused significant increased abdominal obesity, sarcopenic obesity, SAT and VAT quickly after initiation. This may lead to serious metabolic disturbances in long-surviving patients.[Table: see text]


Many organisms are known to regulate seasonal behaviors and physiological processes in response to day length changes through photoperiodism. Extreme changes in photoperiods have detrimental effects on human health, which can impair development and serve as the origin of adult diseases. Since the seminal work by Bünning in 1936, there are studies supporting the view that organisms can measure the day length through an endogenous 24-hour cellular circadian clock. However, the mechanisms involved in measuring seasonal or day-length changes are not understood. In the current study, we performed a genome-wide association study (GWAS) on photoperiodism using the Drosophila Genetic Reference Panel. The GWAS identified 32 candidate genes responsible for photoperiodic regulations. The knockout mutants of the top four candidate genes (Protein Kinase C delta (Pkcdelta), Glucuronyltransferase-P (GlcAT-P), Brain-specific homeobox (Bsh), and Diuretic hormone 31 Receptor (Dh31-R1)) were analyzed for their photoperiod and circadian period phenotypes. PKCdelta and GlcAT-P mutants show a significantly different photoperiod response compared to that of the wild type strain, and also had an altered circadian period phenotype. Further molecular characterization revealed that the mutant two independent mutant alleles of PKCdelta with a defective catalytic domain had distinct photoperiod responses. Taken these data together, we concluded that there is overlap between the circadian clock and photoperiodic regulations in Drosophila, and PKCdelta is a component that is involved in both circadian and photoperiodic regulations. By identifying novel molecular components of photoperiod, the current study provides new insights into the genetic mechanisms of determining the seasonal changes.


Throughout the reconnaissance which would lead to battle in Aboukir Bay in 1798, RearAdmiral Nelson lamented his want of frigates. A summary of the employment of those which were available for allocation by Admiral St Vincent, the commander-in-chief, revealed that the 36-gun Thalia, commanded by Captain Henry Paulet, was 'sounding around Cape Spartel'.1 Why, at such a critical juncture, was her allocation to this task so important? If St Vincent's ships blockading Cadiz were forced off station by westerly gales or the appearance of a superior enemy, they needed an alternative rendezvous. The anchorage off Gibraltar was unsuitable, since it lies at the eastern end of the strait between Europe and Africa through which a strong surface current flows in from the Atlantic. Favourable winds were essential to enable a ship to work back out into the ocean and a warning to take care 'not to be sucked into the Gut Stream' was included in a navigational briefing for all the masters of the squadron from Mr Jackson, master of St Vincent's flagship Ville de Paris.2 Like a number of his successors on station, St Vincent collected navigational information and sought to supplement it with frontline hydrographic data gathering.3 A chart made by the Spanish hydrographer Vicente Tofiño indicated an anchorage beyond Cape Spartel at the southern corner of the Strait of Gibraltar, off a shallow indentation in the coast called Jeremias or Jeremie Bay. This had been used by British cruisers combating French corsairs in the Strait.4 Was it suitable for a substantial force of ships? On Monday 7 May 1798 Captain Paulet was summoned onboard the Ville de Paris to receive orders drawn up for him the previous evening. He was to employ


In this short paper, we will introduce a simple model for quantifying philosophical vagueness. We will then discuss some of the implications of this model including the conditions under which the quantification of X='nifty' leads to pan-nifty-ism. Understanding this leads to an interesting insight the reason a framework to quantify consciousness like Integrated Information Theory (IIT) implies (forms of) panpsychism is because there is favorable structure already implicitly encoded in the construction of the quantification metric.


A surface of bodies in the solar system has been exposed by numerous numbers of impact craterings. The impact craters are formed by the hypervelocity impact of meteorites or interplanetary bodies. The impact craterings basically occur at random on the planetary surface. However, the surface of the Moon, which has same rotation and revolution periods, is expected to indicate a bias of spatial distribution of craters even though the surface has a same formation age. According to theoretical analyses, cratering rate altered by this synchronized rotation effect indicates maximum at the apex of leading side and minimum at the trailing side (Zahnle et al., 2001; Le Feuvre and Wieczorek, 2011). On the other hand, this asymmetry of crater spatial distribution by synchronized rotation effect was assessed by Morota et al. (2005) and Werner and Medvedev (2010). Morota et al. (2005) showed that number density of rayed craters at the apex is the highest on the lunar surface. Werner and Medvedev (2010) showed that peak of high number density of rayed craters observed at the distance of about 60? from the apex where is at the leading side including the apex. Because the formation term of rayed craters is in the past from the present to 1 Ga, the synchronized rotation effect of impact cratering had been achieved in this term. A purpose of this research is to assess the spatial distribution of the global lunar craters without distinction of rayed or not. The assessed craters contain older craters than that of rayed craters, so we could evaluate the synchronized rotation effect at the ancient time before the rayed crater formation. By using the Voronoi tessellation, the global spatial distribution of the lunar craters have the potential of differences by assessing several crater-sets. A result of this research might suggest that the synchronized rotation effect to the lunar craters was not identified in the term before rayed crater formation. In addition to this result, we confirmed the effect of secondary craters which were produced by the Orientale basin formation near the apex.


The approximation of the age distributions of cancers was carried out using a complex mutational model presented in our work [1]. Datasets from the American National Cancer Institute (SEER program) were used. We approximated the datasets for the age distributions of lung, stomach, colon and breast cancer in women; cancer of the lung, stomach, colon and prostate in men. The average number of mutations (required for cancer formation) averaged over the four types of cancer is 5 mutations per cell in women and in men. The average (over the four types of cancer) mutation rate is estimated as 1.0 · 10 −1 mutations per year per cell for women and 3.8 · 10 −1 mutations per year per cell for men. This article is a continuation of work [1].


1. The moisture-curing composition containing! a) at least one polymer P with silanfunktsionalny end groups of formula (I)! ! wherein R1 is an alkyl group with 1-8 C-atoms, in particular methyl or ethyl group; ! R2 is an acyl group or an alkyl group with 1-5 C-atoms, particularly methyl group or ethyl group or an isopropyl group; ! R3 represents a linear or branched, where appropriate, a cyclic alkylene group having 2-12 C atoms, optionally with aromatic moieties and, if appropriate, with one or more heteroatoms, especially nitrogen atoms; and! a is 0, 1 or 2, preferably 0 or 1; and! b) at least one reaction product R, prepared from at least one aminosilane A1, with at least one primary amino group and,! at least one non-silane groups alkene M of the formula (II) or (III), or (IV)! ! ! ! where R9 is R12 or -CN, and! R10 is a substituent selected from the group consisting of -COOR12, -CONHR12, -CON (R12) 2, -CN, -NO2, -PO (OR12) 2, -SO2R12 and -SO2OR12,! R11 is a substituent selected from the group consisting of - R12, -COOR12, -CH2-COOR12 and -CN, and! R12 represents a hydrogen atom or a monovalent, optionally having a heteroatom, a hydrocarbon radical having 1-20 C-atoms. ! 2. The moisture-curing composition according to claim 1, characterized in that silanfunktsionalny polymer P is a polymer P1, obtained by reacting an aminosilane A2 with a polyurethane polymer having terminal isocyanate groups, the aminosilane A2 has formula (V)! ! wherein R4 represents a hydrogen atom or a linear or branched hydrocarbon radical having 1-20 C-


In this paper, the bilinear collocation method is introduced to solve the fuzzy Black-Scholes equation. In this case, the solution is approximated by the functions which are considered on the rectangle. The method is performed on two sample examples to show the efficiency and importance of the proposed scheme.


Background: High prevalence and high mortality rates associated with healthcare-associated Infections (HAI) indicate there is a need to prevent HAIs from spreading. Cleaning and disinfection of hospital surfaces are fundamental to preventing HAIs, as is the confirmation of the success of these processes. Adenosine triphosphate bioluminescence has been identified as a quicker way to confirm cleaning, but questions remain regarding its specificity regarding microorganisms important to HAIs. Methods: This study evaluated ATP bioluminescence' se fficacy in determining microbial contamination on 17 surfaces from the healthcare environment, and to determine if the ATP measurements of Acinetobacter baumannii, Candida albicans, Enterococcus faecalis, Escherichia coli, Mycobacterium smegmatis, and methicillin-resistant Staphylococcus aureus corresponded to quantitative microbiology. Results: A strong positive correlation was discovered for each of the six organisms associated with HAIs, as well as an additional 'all organisms' analysis that combined all the six organisms. Conclusion: This study demonstrated a correlation between ATP bioluminescence measurements and quantitative microbiology; however, it was not as strong at low bacterial concentrations. Additional keywords: Acinetobacter baumannii, Adenosine triphosphate (ATP), ATP measurement, Candida albicans, Enterococcus faecalis, Escherichia coli, healthcare-associated infections, Mycobacterium smegmatis, and methicillin-resistant Staphylococcus aureus.


A simple, rapid, and accurate RP-HPLC method was developed for the determination of tolterodine in solid pharmaceutical dosage form. The method showed a linear response for concentration in the range of 1-15μg/ml using acetonitrile:potassium dihydrogen phosphate (50:50,v/v) as the mobile phase with detection at 284 nm and a flow rate of 1ml/min. The method was statistically validated for accuracy, precision, linearity, range, robustness, and stock solution stability. Recovery studies of the dosage form were also carried out and the mean recovery was found to be 98.35±1.01 %. Due to the simplicity, rapidity, and accuracy the method could be used for routine quality control analysis.


8 Fatimah Adisa Physical Science and Engineering Exploring Single Celled hPSC Viability Using Alginate Hydrogels Fatimah Adisa; Thomas Richardson, PhD; Ipsita Banerjee, PhD Human pluripotent stem cells (hPSCs) have the ability to self-renew and become any cell type in the body through stage-wise differentiation mimicking development, making them ideal for drug discovery and treatment of several degenerative diseases such as Alzheimer's and Type 1 Diabetes. Before hPSCs can be manufactured on a large scale, research must first focus on preventing or minimizing dissociation-induced hPSC cell death. Current research in our lab focuses on the use of peptides (HAV10, ADT10, HAV6, and ADT6) to prevent this cell death. In order for these peptides to be effectively presented to the hPSCs during cell culture and growth, they must be attached to a supportive substrate. Alginate hydrogel beads were used as a supportive substrate to simulate the use of a 3D platform. Overall, the higher sequenced peptide-conjugated hydrogels (ADT10, HAV10) better supported hESCs and their proliferation. They showed strong initial and continued support of hESCs. These hydrogels also maintained the pluripotency of hESCs upon culture and encapsulation. Identifying the best peptide for use in an alginate hydrogel can lead to research of the in vivo use of these hydrogel capsules and identification of any synergistic effects that come from combining peptides at different concentrations.


A new method to control the bias angle of asymmetric Mach–Zehnder interferometer‐based LiNbO3 photonic sensor for accurate intensive E‐field measurement has been proposed and experimentally demonstrated in this article. By adjusting the wavelength of a tunable laser using a microcontroller unit, the sensors can have a linear operating point while not distort the E‐field under measurement. This method successfully controls such LiNbO3 photonic sensor without distorting the output optical waveform. Linear characteristic of this sensing system with proposed control system has been measured and the correlation coefficient between measured and fitting is 0.999 from 160 to 840 Kv/m. All these prove wavelength tuning is available for photonic sensors to detected and extract E‐field accurately. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2326–2329, 2013


Abstract. The effect on blood pressure of monounsaturated and (n‐6)polyunsaturated fatty acids was studied under strict dietary control in normotensive subjects. For 17 days 31 women and 27 men received a control diet providing 19.3% of energy as saturated fat. Then subjects were randomized over two test diets: one diet provided 15.1% of energy from monounsaturated and 7.9% from polyunsaturated fatty acids ('mono diet'), and the other diet provided 10.8% from monounsaturated and 12.7% from polyunsaturated fatty acids ('poly diet'). Saturated fat intake was now 12.8% on both diets.


In this new technology era, the cybersecurity on the new generation renewable energy systems is constantly being tested to the limit on many ways. In order to ensure proper functionality and protection for these renewable energy systems and users is necessary to test these to ensure safe operation under hazardous conditions or other kind of threats. Given that some technologies currently implemented on renewable energy systems (like smart 3-Phase Inverters) are fairly new, a whole new world opens for threats like attacks generated by malicious actors. One example of these highly dependable systems are Smart Power Systems. Technology on these Smart Power Systems support several types of communications (mainly wireless) and present a challenge it self with its own vulnerabilities. The focus of this paper is to present the importance of Cybersecurity for improving these smart technologies by exploring its different vulnerabilities and possible testing vectors.


Arsenic is a carcinogen in humans. However, neither the mechanism of action nor the ultimate chemical form of arsenic which causes cancer has been clearly defined. Dimethylarsinous acid is detected in the urine of individuals who ingest arsenic-polluted drinking water. The cytogenetic study in V79 cells using iododimethylarsine, which is easily hydrolyzed to dimethylarsinous acid in water, revealed that dimethylarsinous acid was very cytotoxic (50% growth inhibition concentration; 1.1 ± 0.14 μM), and either induced aneuploids or a high rate of tetraploids (73% at 2.5 μM). Dimethylarsinous acid caused mitotic arrest, since the mitotic index at toxic dose (5 μM) was 13.9%, significantly higher than the control (2.7%). Dimethylarsinous acid significantly increased sister chromatid exchange (SCE) and chromosomal aberrations, most of which were chromatid gaps and chromatid breaks. The cytotoxicity and the activity of dimethylarsinous acid in inducing chromosomal aberration or SCE was as effective as arsenite, but the activity was much lower than that of mitomycin C, which was used as a positive control. The most potent effects of dimethylarsinous acid on the cells were induction of aneuploids, tetraploids and c-mitosis. Our results suggest that toxicity of dimethylarsinous acid is strongly related to the disturbance of the normal cell cycle.


Let p be a prime number with p ≡ 5 ( mod 8 ) . We construct a new infinite family of pairsofimaginarycyclicfieldsofdegree ( p − 1 )/ 2 withbothclassnumbersdivisibleby p . Let k 0 be the unique subfield of Q (ζ p ) of degree ( p − 1 )/ 4 and u p = ( t + b √ p )/ 2 (> 1 ) be the fundamental unit of k := Q ( √ p ) . We put D m , n := L m ( 2 F m − F n L m ) b for integers m and n , where { F n } and { L n } are linear recurrence sequences of degree two associated to the characteristic polynomial P ( X ) = X 2 − t X − 1. We assume that there exists a pair ( m 0 , n 0 ) of integers satisfying certain congruence relations. Then we show that there exists a positive integer N q which satisfies the both class numbers of k 0 ( (cid:2) D m , n ) and k 0 ( (cid:2) pD m , n ) are divisible by p for any pairs ( m , n ) with m ≡ m 0 ( mod N q ), n ≡ n 0 ( mod N q ) and n > 3. Furthermore, we show that if we assume that ERH holds, then there exists the pair ( m 0 , n 0 ) .


In the large literature analysing the contribution of public capital formation to productivity growth, the stance of technology has been unremittingly ignored. However, technological progress is one of the most important determinants of long-run growth in many macroeconomic variables. Output elasticities calculated from long-run cointegrating estimates omitting technology are therefore very likely to be subject to an important omitted variable bias. In a recent paper, Crowder and Himarios (1997) propose to identify technological progress in the data based on the neo-classical growth model's result that the long-run behaviour of the economy is uniquely determined by technology. Once this common long-run growth component is extracted from the data, the production function can be estimated as a 'period-by-period' constraint. In this paper, this approach is extended to allow for a permanent shift in the balanced growth path, implied by the structural reduction of public capital investment. The methodology is applied to Belgian data for the period 1953-96.


Computer games are no longer just a activity played by children. Casual gaming broadened the acceptance of games. If the goal is to motivate people, gaming mechanisms are used in serious contexts. There is a great potential to use such psychological mechanisms. A reason to use it is to attract people to do activities that would otherwise not be done or just done with less enthusiasm. In this work these aspects are important, because the focus is on persuasive technologies in the area of health and fitness. The health providers and healthcare professionals for example often use computer games to prevent, diagnose and treat disease. E-health is a significant phrase nowadays. This paper is focused on different types of games, software and hardware for health and fitness, the challenges of the persuasive technology and finally presents some selected examples for technologies and applications in this subject area.


Ernest Boyer's 1990 Carnegie report, Scholarship Reconsidered, is examined as a "tipping point"—a critical turning point in what is fundamentally valued and rewarded in the scholarly work of faculty members. Special attention is given to the scholarship of teaching and the scholarship of engagement.


This is an essay about Mina Loy's writing of Jewish identity and exile in her poem, 'Anglo-Mongrels and the Rose'


Magnesium, the sixth most abundant element in the earth's crus& is the lightest of all commonly used sauctural metals. Having a density of only 1.74 &". it is one and onehalf times lighter than aluminum, approximately four times lighter than zinc or steel and is comparable in weight to perhalogenated or mica and asbestos Nled plastics. Although pure magnesium is too soft for structural use, the addition of other elements such as aluminum. zinc, manganese and rare earths have produced alloys with enhanced chemical and physical properties. Alloys of magnesium have found considerable use in applications where weight saving is imponant. The automotive industry has been looking increasingly towards magnesium for reducing vehicle weight. thus improving fuel economy, and is currently the major user of magnesium die cast parts. For example. a weight reduction of 125 lb. will yield a he1 economy improvement of 0.2 to 0.5 miles per gallon in the EPA Combined CityHighway tesL1 h a recent perspective of magnesium in automobiles more than forty production applications of magnesium alloys on US cars are listed? Other industries which benefit from magnesium's low weight include power tools, computers, recnational equipment and aerospace. In addition to it's low weight other advantageous propxies include a high-strength-to-weight ratio, excellent dimensional stability, high impact resistance, good creep strength as well as high thermal and electrical conductivity. In addition, magnesium and its alloys are recyclable and present no toxicity hazard?


This paper proposes novel nonlinear electromagnetic force models of a planar switched reluctance motor (PSRM) for accurate optimization design and precise motion of PSRMs. For the mover with exciting current and the adjacent stator blocks, the flux distribution is gained by the finite-element method, the air-gap permeance between the mover tooth and the adjacent stator blocks is deduced using the flux tube method, the total permeance of the mover and the stator blocks is formulated utilizing the magnetic equivalent circuit method, and the magnetic field energy and the coenergy are derived with the obtained total permeance. In addition, the nonlinear electromagnetic forces, including thrust force and normal force, are modeled based on the magnetic field energy and the coenergy. The simulation and experiment are carried out to acquire electromagnetic forces. The results demonstrate that the average relative errors of the simulated and measured electromagnetic forces compared with the theoretical electromagnetic forces are <;10%, and the accuracy and effectiveness of the proposed modeling are verified.


We measured the transport coefficients of InSb, Si and Ge in the magnetic field range of 0 to 4 Tesla near a room temperature. Transport coefficients obtained by measurements were electrical conductivity /spl sigma/, Hall coefficient R/sub h/, thermoelectric power /spl alpha/ and Nernst coefficient N. These experimental results have been verifying by the theoretical calculations based on the band model. We report the experimental results compared with theoretical values in the case of Ge. Theoretical values had qualitative agreements with experimental results.


(57) ABSTRACT An enhanced low-bit rate parametric voice coder that groups a number of frames from an underlying frame-based vocoder, such as MELP, into a superframe structure. Param eters are extracted from the group of underlying frames and quantized into the Superframe which allows the bit rate of the underlying coding to be reduced without increasing the distortion. The Speech data coded in the Superframe Structure can then be directly Synthesized to Speech or may be transcoded to a format So that an underlying frame-based Vocoder performs the Synthesis. The Superframe Structure includes additional error detection and correction data to reduce the distortion caused by the communication of bit


The present analysis compares HIV and HCV prevalence and associated gender-specific risk patterns of dual users (i.e., crack smokers who inject drugs) and never injectors. Two logistic models, one restricted to female and the other to male crack smokers, were constructed to identify gender-specific risk factors associated with dual use (p < 0.05). Of 437 crack smokers, 246 (56%) were dual users while 191 (44%) were never injectors. In a fitted logistic regression model, dual use among female crack smokers was associated with HCV infection (adjusted OR = 4.65, 95% CI: 1.92–9.70), exchanging sex for money, drugs, or shelter while using crack (aOR = 4.47, 95% CI: 1.56–12.80), having a casual partner who injects (aOR = 4.13, 95% CI: 1.05–16.26), having equipment broken or confiscated by police without being arrested (aOR = 3.66, 95% CI: 1.43–9.34), and HIV infection (aOR = 2.07, 95% CI: 1.18–5.96). Among male crack smokers, dual use was associated with HCV infection (aOR = 5.34, 95% CI: 2.10–13.18), exchanging sex for money, drugs, or shelter (aOR = 3.25, 95% CI: 1.59–6.65), crack use history ≥ 5 years (aOR = 2.16, 95% CI: 1.29–3.63), and smoking in a group of unknown people (such as crack houses, alleys; aOR = 1.70, 95% CI: 1.10–2.81). These findings highlight the need for evidence-based prevention and harm reduction initiatives that directly targeting crack cocaine smokers, with particular attention given to female dual users of injection drugs.


1. The term turkey coryza (TC) was first used in Canada in 1967 to describe a clinically distinct, acute respiratory disease of turkeys. TC was recognized in Iowa in 1971. Following greater awareness of TC, others recalled similar disease outbreaks that occurred in turkeyproducing areas for at least the last three decades. As the number of turkeys being reared in confinement has increased, TC has been identified as an increasingly important respiratory disease and cause of economic loss.


Constructing residential houses with cold-formed steel in Australia dates back to the 1940's when there was a shortage of timber for use in the industry. This subsequently led to the formation of the National Association of Steel-Framed Housing (NASH) in 1982 with the objective of promoting the use of cold-formed steel in the construction industry, in particular for application to construction of low-rise residential houses. Over the last few decades, NASH has made significant progress in promoting steel and has led to the inclusion of steel-framed housing in the Building Code of Australia (BCA) and the development of a standard on residential and low-rise steel framing. Conventional detached housing is the largest single form of residential construction in Australia with approximately 120,000 built in 2015. Therefore, the safety, durability, performance and long-term low operational costs over the 50-year design life of a typical residential house are of significance. Constructed residential houses satisfying these requirements would not only translate to significant savings to homeowners personally but also to the nation. This paper discusses the benefits of using cold-formed steel for constructing low-rise residential structures. Based on a full-scale experimental study that was undertaken to assess the overall performance of a brick veneer steel-framed structure, the performancebased requirements of residential houses built of cold-formed steel framing are evaluated and discussed.


Iterative shrinkage/thresholding algorithm (ISTA) is a well-studied method for finding sparse solutions to illposed inverse problems. In this letter, we present a data-driven scheme for learning optimal thresholding functions for ISTA. The proposed scheme is obtained by relating iterations of ISTA to layers of a simple feedforward neural network and developing a corresponding error backpropagation algorithm for fine-tuning the thresholding functions. Simulations on sparse statistical signals illustrate potential gains in estimation quality due to the proposed data adaptive ISTA. 2016 IEEE Signal Processing Letters This work may not be copied or reproduced in whole or in part for any commercial purpose. Permission to copy in whole or in part without payment of fee is granted for nonprofit educational and research purposes provided that all such whole or partial copies include the following: a notice that such copying is by permission of Mitsubishi Electric Research Laboratories, Inc.; an acknowledgment of the authors and individual contributions to the work; and all applicable portions of the copyright notice. Copying, reproduction, or republishing for any other purpose shall require a license with payment of fee to Mitsubishi Electric Research Laboratories, Inc. All rights reserved. Copyright c © Mitsubishi Electric Research Laboratories, Inc., 2016 201 Broadway, Cambridge, Massachusetts 02139 LEARNING OPTIMAL NONLINEARITIES FOR ISTA 1 Learning optimal nonlinearities for iterative thresholding algorithms Ulugbek S. Kamilov, Member, IEEE and Hassan Mansour, Member, IEEE Abstract—Iterative shrinkage/thresholding algorithm (ISTA) is a well-studied method for finding sparse solutions to illposed inverse problems. In this letter, we present a data-driven scheme for learning optimal thresholding functions for ISTA. The proposed scheme is obtained by relating iterations of ISTA to layers of a simple feedforward neural network and developing a corresponding error backpropagation algorithm for fine-tuning the thresholding functions. Simulations on sparse statistical signals illustrate potential gains in estimation quality due to the proposed data adaptive ISTA.


【Objective】It aims to research the influence of 1-Methylcyclopropene(1-MCP) on the storage period and the quality of Aizoon Stonecrop herb.【Method】When it was treated by 4℃ storage conditions and four concentrations of 1-MCP(0.5,1,1.5,2μg/m3),the change of the respiration rate,the weight loss rate,the contents of chlorophyll,the contents of vitamin C in Aizoon Stonecrop herb during the storage period was observed.【Result】Treated with 1-MCP,it could significantly prolong the storage period and maintain the quality of Aizoon Stonecrop herb.Even the best effect was revealed in the contents of 1 MCP(1.5 μg/m3).The storage period could be prolonged as long as 30 days,12 days longer compared with the control groups.Compared with the control group under the storage conditions of 1.5 μg/m3,it was found that the respiratory intensity is 0.398 times;loss rate was 0.84 times;chlorophyll content was 2.43 times;the content of Vc was 1.09 times.【Conclusion】When the respiration of Aizoon stonecrop herb was inhibited by 1-MCP,its storage period could be extended 1.67 times and meanwhile the good quality remained retained.


ABSTRACT Clinical psychoanalysis and queer theory have at their core a deep exploration of sexuality. Although the link between shame and sex has generated a strong theoretical reflection (Butler, 1993; Dimen, 2013; Saketopoulou, 2013, 2014; Sedgwick, 1993; Stein, 1997, 2012; Straker, 2007), shame is in this literature primarily a threatening affect in need of psychic elaboration. In contrast, I look at shame as a critical and surprising intervention provoked by the analyst. I argue that analysts perform in their work not only psychic labor but also "excessive" nonverbal states which challenge the established boundaries of the analytic relationship. I show that such moments function as "cognitive strikes," which can be productively deployed by analysts to reap their benefits. The aim of my argument is to show that the analysts "enter the perverse" when they momentarily stop processing difficult mental states. According to the professional ideal of "mentalization" (Fonagy & Target, 1996), psychoanalysts are put in the position to permanently do cognitive work. Yet refusing this demand offers the analyst the freedom to shift the relationship between a paid laborer and a beneficiary of therapeutic work. I theorize these noncognitive acts of "excessive shame" to expand on and criticize theories of queer performativity such as Judith Butler's and Eve Sedgwick's. The first contribution of this article is to draw the attention of clinicians to queer work that theorizes the emergent materiality of affects. The second contribution is to ask queer psychoanalytic theorists to take seriously the potential of surprising interventions which interrupt the demand to incessantly perform mental labor for their clients.


Iron and copper were determined on 47 samples of virgin olive oils from Molise, by using atomic absorption spectroscopy The oils, partly taken from the local mills and partly extracted in laboratory from many olive cultivars, were produced in the periods of 1993-94 and 1994-95. Every sample was separated in two parts one of which was analyzed immediately while the other was preserved in glass containers closed tightly in a cool and dark room. With the aim to provide a contribution to the awareness of the oils from Molise, in addition to the above-mentioned metals, we have also determined the following analytical parameters: free fatty acid content, peroxide value, U.V. spectrophotometric characteristics, total phenols, chlorophylls and fatty acid composition. The contents in iron found in the industrially-produced oils were higher in comparison to the oils extracted in the laboratory; as far as copper was concerned, the differences between the two groups of oils were less evident. After a year, the peroxide value and the spectrophotometric properties of the oils preserved were determined; it emerged that, while the industrially-produced oils presented an advanced level of oxidation, almost all of the oils extracted in the laboratory still denoted low levels of peroxides.


Ultrafine high-temperature (HT) LiCoO2 powders were synthesized by the sol-gel method using polyacrylic acid (PAA) as a chelating agent. The decomposition process of the gel precursor was examined to determine the crystallization temperature and the dependence of the physicochemical properties of HT-LiCoO2 powders on the PAA quantity was extensively investigated. Polycrystalline HT-LiCoOz powders, composed of very uniformly sized ultrafine particulates with an average particle size of 30-50 nm and a specific surface area of 2.3-17 m 2g-1, could be obtained at the lower calcination temperature of 550~ and the shorter calcination time of 1 h compared to the solid-state reaction.


Objective: This study deals with the synthesis of silver nanoparticles (AgNP's) from the extract of the leaves of the plant Putranjiva roxburghii wall. Using biological method, i.e., green synthesis. Methods: The extract from the leaves acts as a reducing and stabilizing agent for the AgNP's. Further characterization was done using various techniques like ultraviolet (UV)-visible spectrophotometry, which shows surface plasmon resonance, Fourier transform infra-red spectroscopy analysis shows formation of various bonds, scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis depicts the distribution and average size of nanoparticles. The antimicrobial activity was also checked against various bacteria and fungi using minimum inhibitory concentration and well diffusion assay. Result: UV analysis shows strong plasmon resonance between 420 and 480 nm SEM analysis shows the distribution of synthesized nanoparticles, whereas TEM analysis shows the average particle size to be near about 5 nm and well diffusion assay proved that these nanoparticles are effective against different microorganisms. Conclusion: P. roxburghii wall. shows strong potential for the reduction of silver from Ag+ to Ag0 and nanoparticles so formed are strongly active against various microorganism. Keywords: Putranjiva roxburghii, Fourier transform infra-red, Scanning electron microscope, Transmission electron microscope.


SaaS is an emerging paradigm for software development and deployment, expected to able to reduce cost. SaaS is also considered as a crucial technology for implementation of cutting-edge technology, such as distributed computing, green computing, and cloud computing. SaaS is requested to be configurable software to satisfy various customers, therefore it is very important to consider every configurability requirement during requirement elicitation. Our research suggests a classification technique to secure completeness of configuration requirement.


To make the teaching mode practical and operable,the paper explored new mode of microbiology experiment teaching in higher vocational education. Taking the job requirements as a key point,the paper proposed to create project teaching carrier. According to working process,a teaching method based on the task-driven approach was put forward to focus on ability cultivation. A multi-dimensional experimental evaluation system is established. After three years of research and practice,a microbiological experiment teaching mode based on working process had been established in authors' college and started to yield results. The teaching mode based on project teaching method of working process conforms to the new requirements of microbiological training in higher vocational education,it worth promoting.


Results are presented of a harmonic analysis of the large-scale cosmic-ray (CR) anisotropy as observed by the Milagro observatory. We show a two-dimensional display of the sidereal anisotropy projections in right ascension (R.A.) generated by the fitting of three harmonics to 18 separate declination bands. The Milagro observatory is a water Cherenkov detector located in the Jemez mountains near Los Alamos, New Mexico. With a high duty cycle and large field of view, Milagro is an excellent instrument for measuring this anisotropy with high sensitivity at TeV energies. The analysis is conducted using a seven-year data sample consisting of more than 95 billion events, the largest such data set in existence. We observe an anisotropy with a magnitude around 0.1% for CRs with a median energy of 6 TeV. The dominant feature is a deficit region of depth (2.49 ± 0.02 stat. ± 0.09 sys.) ×10−3 in the direction of the Galactic north pole centered at 189 deg R.A. We observe a steady increase in the magnitude of the signal over seven years.


We calculate the light `glueball' mass spectrum in N_f=2 lattice QCD using a fermion action that is non-perturbatively O(a) improved. We work at lattice spacings a ~0.1 fm and with quark masses that range down to about half the strange quark mass. We find the statistical errors to be moderate and under control on relatively small ensembles. We compare our mass spectrum to that of quenched QCD at the same value of a. Whilst the tensor mass is the same (within errors), the scalar mass is significantly smaller in the dynamical lattice theory, by a factor of ~(0.84 +/- 0.03). We discuss what the observed m_q dependence of this suppression tells us about the dynamics of glueballs in QCD. We also calculate the masses of flux tubes that wind around the spatial torus, and extract the string tension from these. As we decrease the quark mass we see a small but growing vacuum expectation value for the corresponding flux tube operators. This provides clear evidence for `string breaking' and for the (expected) breaking of the associated gauge centre symmetry by sea quarks.


This study aims to describe the application of the demonstration method in science learning for fourth grade students of SDN 55/I Sridadi. This research is a qualitative research. The informants of this study were fourth grade teachers. Data collection techniques used are observation, interviews, and documentation. Data analysis uses data reduction steps, data display, and drawing conclusions. Based on the results of observations made in class IV SDN 55/I Sridadi, the demonstration method is very appropriate to use for science learning. Teachers and students have been able to carry out the stages of implementing learning using the demonstration method, so that the learning process goes well. The interaction between teachers and students, students and students looks good. In addition, students can interact and really understand the material. However, in the learning process there are several obstacles experienced by the teacher. Among them are limited learning resources, learning tools, learning media, situations that are often not easy to manage and limited time. Based on the results of the study, it was concluded that the implementation of the demonstration method in science learning at SDN 55/I Sridadi had been carried out quite well, as evidenced by the presence of some of the steps of demonstration activities that had been carried out well by the teacher, such as preparing and conditioning students to study, taking attendance, praying and motivating students, conveying learning objectives and materials, to evaluation activities.


Since very little iron is excreted from the body, the development of hypochromic anemia in infants is dependent upon the following factors: (I) the rate of growth (particularly in the first two years of life); (2) the amount of endogenous iron present in the body at birth; (3) the intake and absorption of exogenous iron; (4) the utilization of iron in hemoglobin production, and (5) the loss of iron from hemorrhage or from leakage of protein-bound iron into the gastro-intestinal tract. Influence of Growth: The rapid rate of growth in the first two years of life, and again


Objective To investigate the effects of CS-PAA-EPI polymer magnetic nanoparticle on human bladder cancer transplanted tumor model. Methods Magnetic CS-PAA-EPI nanopaticle was composed by CS,acrylic monomer(AA),EPI and Fe3O4 nanopaticle.Human bladder cancer transplanted tumor model was established.The tumor weight inhibition rate,the tumor volume inhibition rate and apotosis rate were detected,which was used to evaluate the antitumor effects of CS-PAA-EPI polymer magnetic nanoparticle. Results Compared with control group,the tumor weight inhibition rate(83.3%),the tumor volumet inhibition rate(77.8%) and apotosis rate(75.3%) in experimental group were significantly increased(P0.01). Conclusions The effect of CS-PAA-EPI polymer magnetic nanoparticle targeting chemotherapy on bladder caner was much better than that of conventional chemotherapy.We believe that targeting chemotherapy has a good application future in bladder caner therapy.


For some low-lying small island States in the Asia Pacific, a consequence of sea level rise could be partial or even total inundation. Little attention has been given to the options these States might have in international law to halt the potential rise of global sea levels, or to seek special assistance if this disaster cannot be avoided or mitigated. It is argued that the most fruitful course of action for small island States in international law may be to force compliance with the procedural norms of environmental impact assessment, information provision, and consultation, that are contained within two recent multilateral environmental treaties. It is contended that this course of action would not involve having to prove damage and assign liability. The only possibility for refugee status would be reliance on a tentative emerging argument that the definition of a refugee is being extended in customary law.


1675. The court, after citing Professor Crepeau, announced that it was both "fiduciaire el gardienne de lapureti desprincipes du droit civil" and "moteur de devolution de ce droit"and placed liability in contract. The content of that obligation — whether de moyens or de resultat — is to be left to the court of trial assisted (or sustained) by art. 1024 which extends contractual obligations beyond the express terms to all those incident to the contract "by equity, usage or law". Precisely similar problems, based on almost identical Code provisions, come daily before the French courts. To the comparative lawyer, the great interest of these volumes is to show how these issues are handled in a system whose style of judgment is so contaminated by the common law as to be almost candid.


The aims of this research is analyze influence of Operational Cost Operational Income, Net Interest Margin (NIM), Loan To Deposite Ratio (LDR), Capital Adequacy Ratio (CAR), Equity to Asset Ratio (EAR), and Non Performing Loan (NPL) to profitability proxied with Return On Asset (ROA) of conventional bank go public in Indonesia from 2010 to 2014.
This research population is conventional bank listed in Indonesian Stock Exchange during 2010 - 2014 with purposive sampling technique with. Sample used on this research is 25 samples of conventionl bank. Research data used for this research is secunder quantitative data obtained from the audited annual of financial report of go public conventional bank. Analyze used in this research is descriptive statistic analysize, classic assumption test, and multiple linear regression analyzes.
Research result show that Operational Cost Operational Income has a negative and significant association with ROA, Loan LDR and NPL has a negative and no significant association with ROA, NIM has a positive and significant association with ROA, CAR and EAR has a positive and no signifcant association with ROA. Based on Adjusted R2 Analyze, independent variables can explain their influenced to ROA 74,5 %, and the remain was explained by the other variable that is not explained on this research. Based on Goodness Fit Test, all independent variables has significant association with ROA simultanously.


Research of influence of speed of whey movement above membrane and pressure differential on process of ultrafiltration was conducted and key parameters of optimum mode were established. The problem of need for careful preparation of whey prior to entering the membrane unit was solved, which was caused by a design of membrane elements of the rolled or spiral type applied by foreign and domestic developers of the membrane equipment. It is established that process of concoction has to consist of two stages — ultrafiltrations at the first stage and nanofiltration (reverse osmosis) at the final stage. Thus the process of ultrafiltration must be carried out with the use of ceramic membranes, which do not require preparation of whey, have a term of exploitation in 3-5 times anymore as compared to polymeric membranes and regenerated considerably simpler. Information about the developed technology and equipment for the whey processing by membrane methods was given.


The mangrove ecosystem on the coast of Youtefa Bay is very beneficial for the survival of the Indigenous people in Enggros, Tobati and Nafri villages, as well as residents of Jayapura City and its surroundings. The purpose of this study was to calculate the diversity and population of fisheries in a polluted mangrove ecosystem. The research was conducted in the waters of mangrove ecosystem in Youtefa Bay, Jayapura City, Papua. Fish data were collected at 10 locations, using gill nets with a mesh size of 1.5 inches with a length of 150 meters and 2 inches with a length of 150 meters. Physical and chemical parameters of the waters were also measured in each location. Data analysis used the Shannon-Wiener diversity index, dominance index, fish abundance, and fish species composition. This study only found 12 species and 10 fish families, with an abundance of 188 individuals/ hectare living and associated with the waters of mangrove ecosystem. There is a reduction in the level of diversity and abundance of fish in the waters of the mangrove ecosystem in Youtefa Bay, due to damage to the ecosystem, conversion of ecosystems, and pollution that occurs in the decomposition of the mangrove ecosystem. These fishery resources will recover if the mangrove ecosystem is restored by increasing the area of the mangrove ecosystem and controlling waste.


Smad3 is a major transporter in the transforming growth factor β (TGF-β) signaling pathway. It is in charge of the transfer of TGF-β signal from the surface of the cell membrane into the nucleus. The TGF-β signal can be bound to the target gene in the nucleus and regulate its expression. Abnormalities in Smad3 expression level and functional status will lead to abnormal signal transduction, involving cell growth, proliferation, development, differentiation, migration, apoptosis and other basic life activities. This review focused on the differential expression of Smad3 in hepatocellular carcinoma (HCC) and the adjacent tissue. The character of Smad3 in HCC is outlined in three parts: Smad3 upstream signaling source, Smad3 self-assembly maturation and Smad3 downstream effects, which may provide a summary and reference for the follow-up study on Smad3.

Key words:
Transport protein, Smad3; Transforming growth factor β(TGF-β); Activin; Signal pathway; Hepatocellular carcinoma


An accurate perception of the state of smart substation equipment is a strong guarantee for the reliable operation of the large power grid. This article proposes using deep learning for the device condition monitoring and analysis method in a power internet of things cloud edge collaboration mode. The speeded up robust features (SURF) feature detector is used at the edge of the network to accurately collect the interest points from the image data set, providing a reliable and complete sample data set support for the cloud-based deep learning network. Adding the attention mechanism module to the cloud improves the Yolov5 network model, enhance feature extraction, and increase the monitoring and analysis capabilities of the equipment. The simulation results show that the proposed method has achieved a recall rate of 91.21% and an accuracy rate of 90.54% for insulator fault evaluation indicators.


The optimal turned out slab pile(TOSP) problem in the slab yard of iron steel industry is formulated as a binary integer programming model in this paper. This is a quadratic programming model and the coefficients of the objective function are related to the values of variables. Because of NP hardness of TOSP problem, it is difficult, or even impossible, to find the optimal solution to the large scale actual problem. In order to solve TOSP, this paper develops the modified genetic algorithm(MGA) for this problem:1) to construct the genetic coding suitable for the optimal TOSP problem. It can not only generate feasible initial chromosomes, but also ensure chromosome feasibility after crossover and mutation.2) to form a MGA framework:a new cultivating operation is introduced; and crossover operationis improved. The computational experiments with the selected cases of the randomly produced problems show that the proposed new MGA is remarkably better than the original heuristics for Tosp problem, with the best improvement of 7 04%.


Objective To verify efficacy of moxibustion apparatus on pulmonary tuberculosis(PT)and explore adjuvant treatment method for PT.Methods One hundred cases of PT were randomly divided into a moxibustion group and a routine treatment group,50 cases in each.The regular antituberculous


The paper reviews tax policy and reforms in India with a view to identifying factors constraining its low revenue productivity. After setting a framework in terms of best practice approach to tax design and reform, the paper examines important changes in tax policies and trends in tax revenues at Union and State levels. The analysis helps to identify the major shortcomings of the Indian tax system. The fragmented Constitutional assignment of tax on agricultural and nonagricultural incomes to Union and State governments makes it difficult to levy a comprehensive income tax and opens up an easy avenue for avoidance and evasion. Multiple objectives imposed on the tax system result in a plethora of exemptions and preferences causing significant loss of revenue and creating unintended distortions. The government tends to tax those sectors where it can raise revenues easily in ad hoc manner and this causes additional distortions. Difficulty in taxing the unorganised sector incomes further contributes to the narrowing of the tax base. Equally important is the tax abuse by the multinational companies which adopt a variety of means to avoid and evade the tax through base erosion and profit shifting. Poor organizational set and capacity of the administration has been another constraining factor. In general, there is reluctance to carry out tax reforms. The 'tyranny of status quo' arises from the fact that those who gain from the reforms tend to be ungrateful and those who lose tend to be vengeful (Johnson and Myles, 2011). That explains why the reforms are slow and are often ineffective. JEL classification: E 62: Taxation; H2: Taxation, Subsidies and Revenue *Preliminary draft. Please do not circulate beyond the NCAER's preparations for the India Policy Forum 2015, for which this paper has been prepared. ** The author is grateful to Richard Bird for useful comments on the earlier draft of the paper. firstname.lastname@example.com


In the article a typology of concepts based on the achievements of recent years is proposed. This typology is an attempt to more distinctive selection of parametres for different types of concepts based on the integrative approach to the study of concept within the conceptual scheme language consciousness society culture.


Temperature ( T ) dependence of the static and the dynamic electron spin-spin correlation is discussed through the planar 63 Cu(2) nuclear spin-spin relaxation rate 1/ 63 T G and the spin-lattice relaxation rate 1/ 63 T 1 T for YBa 2 Cu 3 O 6.6 ( T c ∼60 K), YBa 2 Cu 4 O 8 ( T c ∼82 K), YBa 2 Cu 3 O 6.98 ( T c ∼92 K), and Tl 2 Ba 2 CuO 6+δ ( T c ∼85 K). The restricted moment sums S =( 63 T 1 T ) AF /( 63 T G ) 2 [∼χ( Q )Γ( Q )] for the lightly doped Cu oxides tend to have constant values at high temperatures and those for the other ones are nearly T -independent at all the measured T ( T c < T <300 K). The T -independent S indicates the validity of (1/ 63 T 1 ) AF ∝ T χ( Q ) for the antiferromagnetic Fermi liquid model. From the experimental values of S , we estimate the ratio 2α s T A / T 0 of the characteristic spin-fluctuation parameters 2α s T A and T 0 .


The market and renewable generation uncertainties cast great challenges to the profit-oriented self-scheduling of commercial virtual power plants (VPP). To address the uncertainty issues, this paper proposes a two-stage minimax regret (MMR)-based optimization model to reach optimal VPP self-scheduling solutions, in which the underneath problem is intrinsically NP-hard. To obtain an exact solution of the formulated problem, we firstly reformulate it into a two-stage robust optimization (TSRO) problem with fixed recourse, then re-solve it by adopting the column-and-constraint generation algorithm. In the numerical experiments, we evaluate the performance of the proposed MMR approach by comparing it with the maximin profit approach and the perfect information approach under different occasions. The results suggest that the two-stage MMR approach can achieve a near-optimal solution. Also, it is demonstrated that the performance of the MMR approach is robust in highly volatile environments and significantly penalizing balancing markets.


This paper studies invariance with respect to symmetries in sensory fields, a particular case of which, scale-invariance, has recently been found in certain eukaryotic as well as bacterial cell signaling systems. We describe a necessary and sufficient characterization of symmetry invariance in terms of equivariant transformations, show how this characterization helps find all possible symmetries in standard models of biological adaptation, and discuss symmetry-invariant searches


The utility model relates to a telescopic boom open rock drilling wagon with a drill rod changing device. The telescopic boom open rock drilling wagon comprises a cab, a chassis assembly, a propeller assembly, a telescopic boom, the drill rod changing device, a rock drilling machine, a control system and a dynamic pneumatic system. The cab is arranged on a base board of the cab of the chassis assembly, the control system is arranged in the cab, the control system is connected with the dynamic pneumatic system, and telescopic length, a pitching angle, a deflection angle, extending quantity of a propelling beam and a pitching angle of the cab are controlled by the control system. A boom base of the telescopic boom is fixedly arranged at the front end of the cab, the propelling beam and the telescopic boom are arranged in sliding and matching mode through a supporting frame on a compensation cylinder, a telescopic end of the compensation cylinder is fixedly connected onto the propelling beam, and extending and retracting of the compensation cylinder can achieve extending compensation of the propelling beam. The drill rod changing device is fixed on the propelling beam and below a transmission rod, and the rock drilling machine is fixed at the upper end of the propelling beam. The telescopic boom open rock drilling wagon can meet requirements for multi-directional drilling and simultaneously is favorable for keeping the integrated center of gravity stable.


The article presents the analysis of the key directions for developing a smart city concept through the prism of perception by residents participating in the strategic guidelines in the context of digitalization and a changing economic space. There has been considered the problem of implementing the concept of smart city and low awareness of residents about the regional policy on digitalization of urban space. Trigger spheres of the economy are proposed, whose digitalization should be carried out in the first place. The actual scenarios for building a smart city are presented, and their prospects for the Volgograd region are determined. A model for the development of smart urban space is proposed. The necessity of a direct financial support for advanced technological solutions for the development of urban systems through subsidies, as well as indirect tax incentives is determined. A smart city requires unconventional solutions and flexibility in municipal policies. Principles are proposed that can contribute to the sound management of sustainable smart cities. The obtained results of the study can be used by local governments to implement the most acceptable scenario for the transition to the concept of a smart city in accordance with the current level of development and preparedness of urban space for digitalization. The main advantage of the transformation of urban space and the use of digital technologies is an increase in the quality of services provided to residents, saving financial resources, time and energy required for the city functioning


Artificial intelligence has its demand in almost every possible field, such as, medical, agriculture, military and so on. In depth, it is used to detect cancerous cells, lane detection, natural language processing, number plate recognition, and also in identification of fire. Fire has its own set of behavioral traits. Its static behavior includes color, texture, brightness and edge characteristics for identification. The movement characteristics and shape will fluctuates incessantly constitute the dynamic behavior of fire. The proposed approach presents an effective way of recognizing fire. It consists of two stages namely, the dynamic behavior extraction and static behavior extraction followed by classification. The pre-trained neural network is used for classification, which is termed as transfer learning. The first stage aids in ruling out all the unnecessary characteristics. The output of the first stage goes through the second stage, where all its static features are studied to put it under the correct category of classification. Index Terms Dynamic, Static, Feature Extraction, Transfer learning.


Abstract : In this paper we survey recent results and present some new theorems on the behavior of Pade approximants for e(-z). The new results include necessary and sufficient conditions for (1) a sequence of approximants to be pole-free in an infinite sector, and (2) a sequence of approximants to converge geometrically in the uniform norm over an infinite sector. (Author)


Boston — A presentation at this year's International Master Course on Aging Skin here suggests that some newer-generation laser models may be used in conjunction with others to treat previously difficult-to-reach violaceous vascular lesions, and even achieve greater results in non-ablative skin rejuvenation.


In this article, we mainly review the parabolic Hessian equation on the exterior region. The existence and uniqueness of solutions with asymptotic properties to the exterior problem of the parabolic Hessian equation were obtained by using the Perron method.


The present article analyses the phenomenon of targeted killing. This controversial practice is widespread and has most notoriously been applied by Israel, the USA and Russia. However, the limited scope allows only to focus on the problems of targeted killing under international humanitarian law (law of armed conflict) even though targeted killing can be analysed under various legal regimes, including international human rights law, the right of self- defence under Article 51 of the UN Charter. For the purpose of the article, targeted killing is defined as 'the premeditated killing of a specific target (person(s)) suspected of terrorism, with explicit or implicit governmental approval.' The advantage of using the term 'targeted killing' is that it is free from preconceived issues of legality, in contrast to such notions as 'extrajudicial execution' or 'assassination'.


Context: PGS involves the genetic study of the embryo's genome to determine their chromosomal arrangement and in this way, selecting euploid embryos for implantation, increasing pregnancy success rates in IVF. Objective: Evaluation in terms of PGS for aneuploidy detection, how the NGS platform Ion-Torrent(TM) along with low-pass whole genome sequencing, provides the ability to evaluate many biopsied trophectoderm cells in order to confirm which euploid embryos were ready-to-transfer in an IVF cycle. Methods: Double-blinded genetic testing with both NGS and aCGH methods of 100 WGA samples amplified by PicoPlex® technique from trophectoderm cells. Patients: A total of 29 female patients (median age 40±5.57 years) were recruited in 30 clinical IVF cycles. Interventions: The ovocytes were inseminated using ICSI following an in vitro procedure. Resulting embryos were cultured until day 5 and trophectoderm biopsy was carried out on 100 blastocysts. Main Outcome Measure: NGS is rapid, highly accurate, robust, sensitive, easily reproducible, and a cost-effective method for detection of chromosomal aberrations that have a significant impact on health or embryo viability. Results: The comparison of PGS results by NGS to well-established aCGH have been concluded with 97.9% (95% CI: 92.6%-99.7%) diagnosis correspondence by both techniques. Both aneuploidy detection and a precise identification of balanced translocations were assessed. The discordance in two embryos was due to a more accurate and reliable screening solution by NGS. Conclusions: This validation study demonstrates the clinical application of this aneuploidy detection method in PGS by NGS in contrast to well-established aCGH. To be fully described in the Program? of the II Satellite? Symposia "New Developments in Genetics". For questions please contact IVF Spain Foundation: firstname.lastname@example.com and Prof. Genazzani.


Li et al. (2005) conducted investigation on mechanical and microstructural behaviour of cementitious materials added with MWCNTs, superficially treated with a carboxilation process. For MWCNTs contents of 0.4 to 0.5% of cement weigh, authors observed increases of 19 to 25% on paste compressive strength. Nonetheless, untreated MWCNTs compressive strength was inferior to the control mixture, although flexure strength increased 22%. Li et al. (2007) verified a modest increase of 4% on compressive strength between treated and untreated CNT's.


Physical-geographical classification of Akhangaran basin is given in this article. Information on the soil types, climate, annual rainfall and human impact on vegetation cover of the Akhangaran river basin was showed. So, this article describes the process of desertification and the factors that anthropogenic influence to them.


We will introduce investigation of atomic motion using high resolution inelastic x-ray scattering (IXS) as beamline practical of Cheiron School. The beamline optics for IXS is more complicated than the other beamlines. Scientific field covered with IXS beamline is also too broad to show in this textbook. We will try to show simpler guidance including scientific background through the beamline practical to understand IXS experiment.


This note considers the nonlinear relation of force-displacement for compression members. The consideration is based on linear treatments for members that have initial curvature or accidental eccentricity, in which the member deformation is assumed to be small and the material is linearly elastic. An example of a doubly braced panel is given to show the effect of nonlinear force-displacement relations of compression members on structures.


The economic development model which established after industrial revolution displays the problems of resource waste,serious carbon emissions,and the high cost of environmental pollution.Therefore,the generation of the low-carbon economic development model has its historical inevitability.The paper draws on the low carbon economy ideas of the western scholar,and points out that there are three conversions including economic theory,concept of development and economic growth model in the process of the traditional economic development mode shifting to the low carbon economic development model.The essence of low-carbon economy is the unity of economic efficiency and ecological efficiency.And it's the final focus of ecological model of economic development.


The increasing users and items restrict the development of collaborative filtering recommendation systems. Then a series of problems, such as sparsity, cold start and scalability, come out. In this paper, we add user preference based on item genre, compute the similarity aimed at user preference. It can reduce the amount of data and improve the rapidity when computing similarity between items, and it can be more veracious and better recommendation quality. The experiment result shows that problems above can be solved with this approach.


The normwise distance of a matrix $A$ to the nearest singular matrix is well known to be equal to $\|A\|/{\rm cond}(A)$ for norms subordinate to a vector norm. However, there is no hope for finding a similar formula or even a simple algorithm for computing the componentwise distance to the nearest singular matrix for general matrices. This is because Poljak and Rohn [Math. Control Signals Systems, 6 (1993), pp. 1--9] showed that this is an NP-hard problem.
Denote the minimum Bauer--Skeel condition number achievable by column scaling by $\kappa$. Demmel [SIAM J. Matrix Anal. Appl., 13 (1992), pp. 10--19] showed that $\kappa^{-1}$ is a lower bound for the com- ponentwise distance to the nearest singular matrix. In our paper we prove that $2.4 \cdot n^{1.7} \cdot \kappa^{-1}$ is an upper bound. This extends and proves a conjecture by Demmel and Higham (in the cited paper by Demmel). We give an explicit set of examples showing that such an upper bound cannot be better than $n \cdot \kappa^{-1}$. Asymptotically, we show that $n^{1+ \ln 2+\varepsilon} \cdot \kappa^{-1}$ is a valid upper bound.