Chengdu-Chongqing Economic Zone,as an important growth pole of future China's economy,has been focused by the world for its quality and rate of development.Chengdu and Chongqing should not only utilize the advantages of relatively good industrial basis but also push forward intensive development of this Zone by industrial collaboration between the regions.The feature of strong relativity between related leading industries and pillar industries in Chengdu-Chongqing Economic Zone should be used to develop 2+9+5 industrial clusters.The research and development of new products and industrially supporting each other in this region should be noticed when developing important industries.Chengdu-Chongqing Economic Zone should integrate industrial deployment into overall urban-rural development,not only sufficiently search for and utilize self-law of market economy but also consolidate the plan,guidance,incentive and cooperation of each level governments between Chengdu and chongqing, make efforts to get support from the central government and to attract the participation from governments,enterprises,media and the people from other provinces and municipalities.


Background: The Caribbean Island nations introduced a school health programme aimed to equipping the youths with life skills to enable them cope better in the society since the 1990s. In Trinidad and Tobago, teachers were trained to deliver this programme to their students in both primary and secondary schools. The implementation of the programme is at best haphazard. This study is an attempt to document the views of the teachers about the training they received pertaining to this programme. Methods: Teachers who have been trained in this programme were purposively selected to document their views through a focus group sessions. Two sets of this group sessions were undertaken with 11 teachers. Their views were reported verbatim and analyzed using Colaizzi's analysis technique. Result: Caribbean Teachers gave their perspectives about their training. Importantly, their views were summarizes in two themes, namely, different training techniques, and concerns. Discussions; Given the mixed result, it is important to ensure that the teachers who are the implementers of the programme receive adequate training so that they will be in a better position to impact on the skills of the youth as envisage by the programme designers. The implications of the findings were discussed vis-a-vis the literature. Conclusion: This study identified some of the good elements of the training the teachers' were exposed to. It also highlighted some areas that require re-visiting if this laudable programme will yield its maximum fruit.


Self-diagnosis (SD) activities require students to self-diagnose their solutions to problems that they solved on their own. This involves identifying where they went wrong and then explaining the nature of their errors—why they went wrong—aided by some form of support. Worked examples (WEs) are often used to support students in SD activities. A WE is a step-by-step demonstration of how to solve a problem. One unresolved issue is why students fail to exploit WEs in SD exercises. Yerushalmi et al., for instance, provided students with written WEs and asked them to self-diagnose their solutions with respect to these WEs. These authors found no correlation between students' SD performance and their subsequent problem-solving performance on transfer problems, suggesting that students had only superficially exploited the written WEs. The aim of this article is to describe a new SD activity that was developed to prompt students to effectively use written WEs when self-diagnosing, and to examine its effectiveness...


In recent years the accumulation of most amino acids by the brain has been well demonstrated by both i n uiuo (Altiszan 1964, Chirigos et al. 1964, Roberts et al. 1959, Roberts & Morelos 1965, and Schain et al. 1967) and in vitro (Adams & Lini 1966, Blasberg & Lajtha 1966, Lajtha & Toth 1962, Leui et al. 1965, Murthy & Rappoport 1964, Neaine 1961, Yoniogaini e t al. 1966) experiments. A rapid efflux of amino acids has also been demonstrated (Laj tha & Toth 1964, Levi et al. 1965). This is sufficiently large to suggest that no significant net uptake occurs in slices or in blocks of tissue taken from whoie brain following intravenous injection into intact animals. The failure to observe a large net accumulation of non-labeled or isotopically labeled amino acids by the brain from the blood has most often been attributed to the restrictive effects of a blood-brain barrier (Laj tha 1962). However, recent reports (Ford et a1 1965, Ford & Rhines 1967) demonstrating sizeable accumulations of labeled amino acids specifically into neurons following intravenous injection suggest that the restriction of transport of an amino acid from blood into brain may not be as marked as previously believed. These studies dcmonstrate a high level of accumulation of lysine, tyrosine, and glutamine, csscntially only into neurons. This accumulation would to a considerable extent be masked by the very low accumulation occurring in ihe large bulk of the surrounding neuropi1 and while matter if the analyses were performed on the very heterogenous blocks of tissue which contain these cells. The determination of the amount of labeled material actually present in these neurons in distinction from that occurring in blocks of brain discloses the significantly high levels of uptake which occur in neurons.


Litigation in the United States is highly adversarial in nature. The Ameri can popular image of courtroom proceedings is of two well-paid lawyers fighting it out before an impassive judge, whose verdict will favor the side marshalling the most impressive arguments or exercising the most ingenuity in uncovering technicalities. Without lawyers there can be no litigation; as Choi (1980:76) points out in comparing Western and Korean legal institutions, "Litigation and court proceedings in the West constitute a competition between private persons; the attorney system in litigation consummates competition at court and thus contributes to the realization of justice. Therefore, denial of counsel is tantamount to denial of justice." In contrast, Koreans routinely venture into civil, family, and crimi nal courtrooms without legal counsel, and the majority of litigants in lower-level civil courts in fact choose to represent themselves. The absence of lawyers in the courtrooms often disturbs American observers of Korea's legal institutions, who tend to view it as an indication that the "rule of law" has not yet taken root. The usual assumption is that Kore ans involved in legal actions would hire a lawyer if they could and, from this, that if few Koreans are represented by legal counsel, it must be that lawyers are too expensive, or inaccessible, or perhaps Koreans are not sophisticated enough to seek professional legal help. In addition, there is the vague notion that there are in Korea judicial scribes, sabopsosa,1 who act as a kind of "people's lawyer" for those who cannot afford attorneys. When I began doing research in the District Court [chibang pop won] in Kwangju,21 was intrigued by the role of professional legal coun


Despite early promise, scholarship has shown little empirical evidence of learning from the news on social media. At the same time, scholars have documented the problem of information 'snacking' and information quality on these platforms. These parallel trends in the literature challenge long-held assumptions about the pro-social effects of news consumption and political participation. We argue that reliance on social media for news does not contribute to people's real level of political knowledge (objective knowledge), but instead only influences people's impression of being informed (subjective knowledge). Subjective knowledge is just as important for driving political participation, a potentially troubling trend given the nature of news consumption on social media. We test this expectation with panel survey data from the 2018 U.S. midterm elections. Two path model specifications (fixed effects and autoregressive) support our theoretical model. Implications for the study of the 'dark side' of social media and democracy are discussed.


We have experimentally demonstrated the long‐range crosstalk of transient chaotic behavior between separate parts of a single p‐Ge crystal. Our experiments focused on the mutual coupling of the different intrinsic current oscillations generated in each part during the electric avalanche breakdown at liquid helium temperatures. Our results help to clarify the unwanted hot‐carrier effects with respect to very large scale integration semiconductor circuits.


The main factors affecting solid-phase Si-metal interactions are reported in this work. The influence of the orientation of the Si substrates and the presence of impurities in metal films and at the Si-metal interface on the formation of nickel and chromium silicides have been demonstrated. We have observed that the formation and kinetic rate of growth of nickel silicides is strongly dependent on the orientation and crystallinity of the Si substrates; a fact which, up to date, has never been seriously investigated in silicide formation. Impurity contaminations in the Cr film and at the Si-Cr interface are the most dominant influencing factors in the formation and kinetic rate of growth of CrSi2. The potentiality and use of silicides as a diffusion barrier in metallization on silicon devices were also investigated. Two phases, Ni2Si and NiSi, form simultaneously in two distinct sublayers in the reaction of Ni with amorphous Si, while only the former phase was observed on other substrates. On (111) oriented Si substrates the growth rate is about 2 to 3 times less than that on or polycrystalline Si. Transmission electron micrographs establish-·that silicide layers grown on different substrates have different microcrystalline structures. The concept of grain-boundary diffusion is speculated to be an important factor in silicide formation. The composition and kinetic rate of CrSi2 formation are not influenced by the underlying Si substrate. While the orientation of the Si substrate does not affect the formation of CrSi2 , the purity of the Cr film and the state of Si-Cr interface become the predominant factors in the reaction process. With an interposed layer of Pd2Si between the Cr film and the Si substrate, CrSi2 starts to form at a much lower temperature (400°C) relative to the Si-Cr system. However, the growth rate of CrSi2 is observed to be independent of the thickness of the Pd2Si layer. For both Si-Cr and Si-Pd2Si-Cr samples, the growth rate is linear with time with an activation energy of 1.7 ± 0.1 ev. A tracer technique using radioactive 31Si (T1/2 = 2.26 h) was used to study the formation of CrSi2 on Pd2Si. It is established from this experiment that the growth of CrSi2 takes place partly by transport of Si directly from the Si substrate and partly by breaking Pd2Si bonds, making free Si atoms available for the growth process. The role of CrSi2 in Pd-Al metallization on Si was studied. It is established that a thin CrSi2 layer can be used as a diffusion barrier to prevent Al from interacting with Pd2Si in the Pd-Al metallization on Si. As a generalization of what has been observed for polycrystalline-Si-Al interaction, the reactions between polycrystalline Si (poly Si) and other metals were studied. The metals investigated include Ni, Cr, Pd, Ag and Au. For Ni, Cr and Pd, annealing results in silicide formation, at temperatures similar to those observed on single crystal Si substrates. For Al, Ag and Au, which form simple eutectics with Si annealing results in erosion of the poly Si layer and growth of Si crystallites in the metal films. Backscattering spectrometry with 2.0 and 2.3 MeV 4He ions was the main analytical tool used in all our investigations. Other experimental techniques include the Read camera glancing angle x-ray diffraction, scanning electron, optical and transmission electron microscopy. Details of these analytical techniques are given in Chapter II.


The study was designed to examine the effect of combined training and aerobic training on cognitive function and functional performance(activities of daily living, lower-extremity strength, dynamic balance) in hemiplegic stroke patients. Twenty-five subjects volunteered to participate and were randomized into one of two groups. Twenty subjects completed the study, and the number of subjects in each group was as follows: combined exercise training group(CET: n=10), aerobic exercise training group(AET: n=10). subjects in CET performed stationary cycling(20 min) and resistance exercise(20 min) using Thera-band simultaneously, and subjects in AET performed only aerobic exercise utilizing the stationary bicycle(40 min). Both groups received a conventional physical therapy. in addition, CET and AET practiced exercise on sixty minutes a day, five days a week during six weeks. Results of the present study were as follows: CET and AET were effective at increasing cognition function, dynamic balance(p<.05). only CET was effective at increasing daily activity living(p<.05). daily activity living, dynamic balance of CET was more significantly increased than AET. In conclusion, CET and AET had positive effects on cognitive function and functional performance in hemiplegic patients. in addition, CET was more effective in enhancing daily activity living, dynamic balance than AET. Therefore, resistance exercise as well as aerobic exercise should be included in the treatment for hemiplegic patients later on.


Motor 56 having a stator support shaft, a cup-shaped rotor, and the rotary support member, the support shaft concentrically fixed to the stator, the rotor is substantially cup-shaped stator disposed radially outward side, is driven to rotate around the stator, the rotary support member disposed between the support shaft and the rotor, relative to the support shaft rotatably supporting the rotor, the rotor is coaxially fixed in the axial direction of the fixed end portion of the air conditioner indoor unit 55 by the axial flow fan 32. This can reduce the number of components, downsizing of the motor axis direction length, the ability of the air conditioner indoor unit is increased.


Let α be an automorphism of a ring R. We study the skew Armendariz of Laurent series type rings (α-LA rings), as a generalization of the standard Armendariz condition from polynomials to skew Laurent series. We study on the relationship between the Baerness and p.p. property of a ring R and these of the skew Laurent series ring R[[x, x −1; α]], in case R is an α-LA ring. Moreover, we prove that for an α-weakly rigid ring R, R[[x, x −1; α]] is a left p.q.-Baer ring if and only if R is left p.q.-Baer and every countable subset of S ℓ(R) has a generalized countable join in R. Various types of examples of α-LA rings are provided.


Chronic heart failure (CHF) is the most common and serious complication of cardiovascular disease. Arterial hypertension is the most common cause of CHF. The study of the problem of heart failure in the early stages of its development is of particular interest to clinicians. At the same time, the diagnosis of CHF in the early stages is important to prevent its further progression. To date, data have appeared on the possibility of early diagnosis of CHF of any etiology and predicting the occurrence of unfavorable outcomes of heart failure using brain natriuretic peptide - B - type Natriuretik Peptide (BNP) In recent years, as a marker of the early (preclinical) stage of CHF in patients with arterial hypertension group B natriuretic peptide (BNP) is used. Serum BNP is becoming the standard in the early diagnosis of CHF. The main stimulus for increased BNP secretion is left ventricular volume overload. Natriuretic peptides (NP) are physiological angiotensin II antagonists in relation to the stimulation of aldosterone secretion. An increase in plasma renin activity and aldosterone concentration causes left ventricular remodeling, accumulation of fibrous tissue, and ventricular overload. The main trigger for BNP is increased myocardial tension.


Endoscopic resection is feasible for superficial tumors in patients with ulcerative colitis; however, endoscopic resection options have not been evaluated comprehensively. We evaluated the efficacy and safety of endoscopic submucosal dissection and endoscopic mucosal resection, and decision making regarding endoscopic resection options for patients with ulcerative colitis.


The title compound is a salt, C(9)H(14)N(+).NO(3)(-), in which two N-H...O hydrogen bonds and two C-H...O hydrogen bonds generate a three-dimensional framework structure. The combination of one N-H...O hydrogen bond and one C-H...O hydrogen bond generates a finite (zero-dimensional) centrosymmetric R(4)(4)(14) aggregate containing two cations and two anions; the combination of the two N-H...O hydrogen bonds generates a one-dimensional C(2)(2)(6) chain of alternating cations and anions, and the combination of one N-H...O hydrogen bond and two C-H...O hydrogen bonds generates a two-dimensional sheet of alternating R(4)(4)(14) and R(8)(6)(34) rings.


Abstract In this article, a new control method is proposed for the stability of Electrical Vehicles (EVs) with 2-motor wheels. This control method provides an optimized limit for the torque levels that produced by the front and rear motors, proportional to the road surface condition, to prevent the vehicle from slipping. In addition, a fuzzy logic-based braking system is proposed to improve vehicle performance during deceleration. The vehicle is described by the model with three degrees of freedom, which provide good accuracy. The tires are modeled according to the magic formula. To evaluate the effectiveness of the proposed method, simulations were performed in the ©MATLAB. The conclusions show that the proposed control method can well maintain the steadiness of the EV on dry and slippery roads when driving straight, accelerating or decelerating, and turning. This will prevent the vehicle from slipping and locking the wheels.


The optical properties of single InAs∕GaAs quantum dots (QDs) were studied as a function of their distance from the air∕GaAs interface. A short-period superlattice structure allows us to controllably shorten the distance between the QDs and the surface in 6-nm steps. The QD luminescence intensity and lifetime measurements show that quantum tunneling effect results in a sharp reduction in fluorescence efficiency and lifetime when the wetting-layer–surface distance is within 9 nm. For distances between 15 and 40 nm, broadening of the photoluminescence linewidths of single QDs was observed. Since exciton recombination time and efficiency are in this case unchanged with respect to bulk QDs, the observed line broadening is most likely due to dephasing or spectral diffusion processes.


India is known as agricultural as well as rural based economy. However, rural society is traditional, conservative and detached from the sources of innovation. In industrialized nations where local economies are integrated components of the national economy and national policies reach citizens in all parts of the nation, it is reasonable to ask weather specific attention should be paid to rural areas, rather than simply relying upon national programs. To reduce the migration rate we need to have a sustainable solution like providing employment opportunities to rural public. Industrial development has greater potential in expansion of economic activities and it will eventually help in development of rural assets along with income generation, development of infrastructure, raising standard of living and per capita income for rural people. Industrialization act as an instrument both of the creating capacity to absorb excess labour power and of catering for the diversification of the market required at the higher stages of economic development. Rural areas are specialised more in agriculture while Industries are located mostly at urban location giving a weak rural-urban linkage which ultimately results in lower pace of development in rural area. This paper is an attempt to analyze the rural economy, fact about small scale industries need of industrialization and industrial sector and especially its role in the development of rural areas in India.


The development and utilization of technology has motives the society's dependence on Information and Communication Technology (ICT). One of technology variants is the zankoline system, which is described as the use of services through the internet. In which it's an e-service system which provides access to students to apply for the region's universities for the undergraduate studies. The research aims to analyze the technology acceptance model (TAM) in order to evaluate students' perspectives towards the use of Zankoline system. The total of 200 forms was distributed and 140 survey response rate was received. Elements that were evaluated comprised of perceived usefulness, perceived ease of use, and intention to use. The collected data were analyzed using SPSS based on the TAM technique via hypothesis test. The findings revealed that the research participants' perspectives were low regarding  the use of zankoline system, this is due to the most of the research participants were not applied to the zankoline and were accepted through direct admission. Keywords: e-government, students' adoption, evaluation, TAM, effectiveness .


In this paper, we develop a density dependent model to describe sperm whale population dynamics in the Gulf of Mexico. For this model, we consider the stability of the extinction equilibrium and prove the existence and uniqueness of a positive equilibrium. We then examine the stability of the positive equilibrium and substantiate the results with numerical simulations using Matlab. Next, we consider the effect of a disturbance, such as the Deepwater Horizon oil spill, on the sperm whale population in the Gulf of Mexico. Describing a disturbance as an event that results in reductions in survival rates for a certain period of time, we examine the recovery time of a sperm whale population following a disturbance, which we define to be the length of time it takes the population to return to a certain percentage of its asymptotic equilibrium value. Through testing various recovery threshold values, reductions in survival rates, and lengths of time over which the survival rates are reduced, we find that the recovery time is sensitive to each of these variables; depending on the values of these three quantities, the recovery time can last anywhere between a few years and many centuries.


Annotation. According to various estimations, the incidence of adnexal neoplasms during pregnancy makes up from 0.19% to 8.8%. Most of cases are diagnosed in the first trimester and their incidence gradually decreases as the period of pregnancy grows. Depending on their size and location, ovarian tumors may be related to an adverse obstetrical result caused by mechanical influence. They increase the risk of abortion (from 0 to 6%), preterm labor (from 5.8% to 10.4%) and mechanical impediment to labor. Aim – studying the peculiarities of the course of labor and the condition of the newborn of women affected by benign ovarian tumors. We have conducted a complex examination of 67 pregnant women with benign ovarian tumors and tumor-like growths found before pregnancy or in the first trimester of gestation (basic group) and 50 women presenting no ovarian neoplasms or any other severe gynecological or somatic pathology (reference group). To identify the risk factors, the basic group was divided into 2 subgroups. The condition of fetuses was assessed with the use of automated cardiotocography analysis based on the Dawes/Redman criteria, with the calculation of the short-term variability (STV). The mean and standard deviation (M ± m) were evaluated at a significance level of p <0.05. Categorical variables are presented as the absolute number of cases in the group and the frequency in percent – n (%). Tests for differences between independent samples in the case of quantitative variables were performed using Student's t test, the Mann-Whitney rank test, and in the case of categorical variables using Fisher's exact test. The obtained results suggest that the course of labor in women affected by benign ovarian neoplasms is characterized by an increased incidence of complications. A significant difference has been established in the incidence of cesarean sections (35.8% vs 8.0% in the reference group, р<0.05), preterm labor (28.4% vs. 6.0%, р<0.05), fetal distress (19.4% vs. 8.0%, р<0.05) and preterm rupture of membranes (17.9% vs. 6.0%, р<0.05). The incidence of almost all complications of labor in Subgroup 1 significantly exceeds the figures from the reference group and the incidence of preterm labor and fetal distress is also higher in comparison with Subgroup 2. The presence of extragenital pathology is a well-known risk factor for perinatal complications, which is also confirmed by our research. A high level of comorbidity of benign ovarian neoplasms with various extragenital diseases also accounts to a certain degree for gestational complications. Thus, pregnancy in women affected by ovarian tumors implies an increased risk of obstetrical and perinatal complications, in particular, threats of miscarriage and preterm labor. The studies of this issue lack systematization, are often controversial and fragmentary. There has been practically no research on the risk factors for such complications and the ways of their prognostication and prevention.


Graph monitoring program plays an important role in the synthesis automation of substation and the simulation training of power system. In this paper a new technology used to develop graph monitoring program is introduced, which includs the developing tools of Delphi and OOP. Using this technology to design graph monitoring program can greatly shorten the developing cycle and reduce the developing cost. The developed program has the advantage of high coding efficiency, rapid running speed, strong expandable performance and easy maintainance.


Diphenyltetrazole (DPT) is decomposed by UV light and the decomposed product is highly reactive with phenol group. Therefore, combination of DPT and polyvinylphenol (PVP) gives negative type UV resist for aqueous alkali development. The PVP-DPT resist is able to apply to KrF excimer laser lithography.The characteristic curve for KrF excimer shows 86mJ/cm2 for sensitivity and 2.9 for gamma. SEM picture given by direct con tact printing indicated resolution less than 0.5μ. Spectral analysis on the DPT resist was carried out and the hardening mechanism discussed.


Detecting and dealing with congestion in delay tolerant opportunistic networks is an important and challenging problem. In this paper we describe CAFREP, a unified congestion control framework for routing in such networks that adapts both data sending rates and data forwarding policies through a novel reactive fully distributed approach. CAFREP enables congestion control by detecting and reacting to congested nodes and congested parts of the network by using implicit hybrid contact and resources congestion heuristic. CAFREP exploits localized relative utility based approach to offload the traffic from more to less congested parts of the network, and replicate at adaptively lower rate in parts of the network with higher congestion. We extensively evaluate CAFREP against a number of state of the art adaptive and non-adaptive DTN routing protocols across a number of different metrics over three real trace driven experiments with different mobility and connectivity patterns such as Infocom 2006, Rollernet and Dieselnet CRAWDAD data sets. We show that CAFREP performs well in three different connectivity datasets and continuously outperforms four other protocols in terms of maintaining higher node availability and success ratio while keeping lower delays, lower packet loss rates and lower number of forwarded packets for increasing congestion levels.


Background: Serum free light chains (sFLC) and immunofixation (IFE) analysis are used to detect monoclonal proteins. We noticed that some multiple myeloma (MM) patients (pts) had negative IFE results despite very high sFLC levels. This analysis was done to determine the frequency of this finding in a large cohort. Methods: Following IRB approval, samples with simultaneous sIFE and sFLCs ordered from 1/2013 to 9/2013 were identified by querying our lab electronic database. Freelite (R) Human Kappa & Lambda Free kit (The Binding Site, Birmingham, UK) was used for sFLC and SPIFE® ImmunoFix-15 gels (Helena Laboratories, Beaumont, TX) for IFE. Clinical review was performed for a subset of patients with discrepant results between the two assays. Results: 4404 samples from 2200 pts were identified with simultaneous sFLC and sIFE results. Overall 348 of 4404 (7.9%) samples had an abnormal sFLC ratio but a negative sIFE. Of 205 pts (457 samples) with involved serum free kappa above the expected IFE threshold (200 mg/L), 42 pts (103 samples) had negative sIFEs (20.5% pts; 22.5% samples) despite median free kappa of 556.6 mg/L (range 208.1 to 4954.4). This was much less common for involved free lambda. Only 4 of 107 pts with free lambda above 200mg/L had negative sIFEs (3.7%). Information of the nature of the plasma cell disorder was available on 40 of the 42 patients with free kappa > 200mg/L and negative IFE. In this group, 62.5% (n=25) had symptomatic MM, 12.5% (n=5) had asymptomatic MM, 5% (n=2) had light chain amyloidosis, 5% (n=2) had both amyloidosis and MM, and 15% (n=6) had MGUS or a not yet fully worked up plasma cell disorder. Conclusions: Serum IFE, with a commonly used kit, missed about 20% of patients with free kappa above the expected IFE threshold, while free lambda was detected more reliably. Results suggest current criteria for complete remission which rely on immunofixation and bone marrow plasma cell infiltration may need to be revised for kappa light chain myeloma. Disclosures No relevant conflicts of interest to declare.


The search for markers ofplant embryogenesis is an important aspect ofmodern plant breeding and isozyme analysis remains a powerful tool to register cytodifferentiation in plants. The use of in situ cytochemical techniques to study the proteins which are expressed during embryogenesis has been underestimated so far. This chapter, mainly based on our earlier work (Fransz et al. 1989a,b), emphasizes the possibilities and applications of combined biochemical and cytochemical studies. Besides giving a survey of the literature about isozymes as biochemical markers during embryogenesis, especially for maize, it accentuates the use of cytochemical techniques to study the in situ expression of these Isozymes.


Abstract 3254 The antimetabolite hydroxyurea (HU) is the only widely available therapy for reducing complications of sickle cell anemia. It is not widely prescribed due to concerns about adverse effects, including cancer. Insufficient data currently exist regarding its leukemogenic potential. HU associated leukemia in sickle cell anemia is exceptionally rare, with only 6 literature reports. Whether such cases are coincidental or related to HU remains unanswered. We identified a 33 year old male with pure erythroid leukemia (formerly M6 AML) and a unique combination of sickle cell anemia, HU treatment, and short treatment latency. Cytogenetics showed a complex karyotype with 5q rearrangement, 7q deletion, losses of chromosomes 15–22 and Y, suggesting a therapy related etiology. To date, no sickle cell anemia AML cases have undergone in-depth genomic analysis to determine if HU has an etiologic role in susceptibility to therapy related leukemogenesis. High density SNP genotyping was performed with 2.5 million markers to understand progressive chromosomal disease changes. Comparison of germline DNA prior to HU and tumor DNA identified 10 mosaic aneuploidy events present at AML diagnosis including losses at 5q, 7q and 17p and gains at 19p. Whole exome sequencing was also performed on the patient9s germline, tumor and relapsed tumor DNA. We identified 33 putative somatic missense mutations including a validated somatic TP53 mutation, however somatic mutations were not present in commonly mutated AML genes like NPM1 , RUNX1 or IDH1 . Genome-wide cytogenetic band enrichment analysis of exome sequence data using the Gene Set Analysis Toolkit suggests the presence of a significant enrichment of mutations along chromosome 19p, and the same analysis of peripheral blood gene expression from an unrelated cohort of 10 sickle cell anemia subjects with brisk hematopoietic activity also suggested association of chromosome 19p with stress erythropoiesis. Together, the mosaic aneuploidy and exome sequence analysis converged on a region of 19p potentially important to the pathogenesis of pure erythroid leukemia and possibly stress erythropoiesis. This region extends at least 1.9 Mb and includes 58 genes. We are validating mutations in this region and exploring the role of 19p during stress erythropoiesis to further determine the significance of this finding. Specifically, several 19p mutations have been introduced into the BaF3 cell line to investigate their role in myeloid cell growth. Investigation of this rare leukemia case offers a unique opportunity to elucidate the pathogenesis of erythroleukemia and possibly to determine if HU therapy is associated with leukemogenesis. Disclosures: No relevant conflicts of interest to declare.


Several hospitals are developing standards of care, referred to as pathways, for HIV and tuberculosis (TB) treatment to give providers well-established step-by-step management guidance. The Tucson Medical Center uses an HIV critical path which allows for the variable diagnosis and unpredictable nature of HIV disease. Jackson Memorial Hospital in Miami developed a critical path for patients co-infected with HIV and TB. The Miami program has reduced readmission rates for TB patients from 12 percent to 2 percent, and cut the length of hospital stays in half.


The technique of ground penetrating radar(GPR) is a high technology of examination,which has a lot of advantages such as high degree of accuracy,non-stop operation,non-destructive,rapid survey,audio and visual intuitions,etc.This paper presents the technique of GPR,and the application of GPR in the quality examination of subgrade retaining wall of railroads.The result of the application indicates that the technique of GPR is better than the traditional one.It is worthwhile to promote and apply the technique of GPR in the engineering examination.


The relation between the signal-to-noise ratio enhancement and the correlation function of the structure noise for varying acoustic parameters has been deduced. Spatial averaging in a simple case has been discussed and expressions for the correlation function and the signal-to-noise ratio enhancement have been obtained. The calculated results are in good agreement with the experimental ones.


Development of passive solid-state ferromagnetic sensors suitable for assessing damage accumulation in composite materials requires an accurate, reproducible detection technique. The solid state sensors gradually transform from a paramagnetic phase to a ferromagnetic phase as a function of applied strain. The irreversible and strain dependent formation of ferromagnetic material passively provides a magnetic signature useful in nondestructively assessing peak strain exposure. This peak strain signature can be used to identify and quantitatively estimate the degree or extent of accumulated composite material damage. Embedded sensors were continuous 254-/spl mu/m diameter wires positioned beneath the first or second surface ply along the longitudinal axes of tensile specimens. Single embedded wire sensor configurations were evaluated. This paper discusses the development and results obtained for a giant magneto-resistive (GMR) sensor detection system for measuring the ferromagnetic response of the sensor wires after strain-controlled tensile testing. Tensile testing was done at levels ranging from 0-4% total strain.


Despite the importance of oral care in the preven‐ tion of aspiration pneumonia, the association between oral hygiene and the prevalence of pneumonia‐causing bacteria has not yet been determined. The present study is a cross‐sectional study aimed at determining the association between the original point‐rating system used during oral examinations (the prompt non‐invasive oral assessment) and the prevalence of pneumonia‐causing bacteria in a population of hospitalized patients with malnutrition. The nutrition support team cared for 61 patients; 6 were excluded as they were not eligible. Bedside analyses were conducted using the point‐rating system. The findings were analyzed to determine the association between the prompt non‐invasive oral assessment and the detection of pneumonia‐causing bacteria. Patients who tested positive for pneumonia‐causing bacteria (n=13) received significantly higher total and hygiene item scores than those who tested negative (n=42) [median (25th, 75th percentile), total score, 6 (4, 7) vs. 3 (1, 5), P=0.02; hygiene score, 2 (1, 3) vs. 1 (0, 2), P=0.02]. In the receiver operating characteristic analysis, a total oral assessment cut‐off score of 4 was identified as optimal for detecting pneumonia‐causing bacteria. Additionally, a multi‐ variable analysis revealed a high odds ratio for the presence of pneumonia‐causing bacteria in patients with poor oral hygiene (odds ratio, 2.09; 95% CI, 1.04 to 4.22). Thus, the present study demonstrates that the prompt non‐invasive oral assessment is a simple and effective tool for detecting pneumonia‐causing bacteria in hospitalized patients.


For λ ≥ 0 and 0 ≤ α < 1 < β, we denote by K(λ,α,β) the class of normalized
 analytic functions satisfying the two sided-inequality α < K (Zf'(z)/f(z) + z2f''(z)/f(z))<β (z  U), where U is the open unit disk. Let KΣ (λ, α, β) be the class of bi-univalent functions such that f and its inverse f-1 both belong to the class K(λ, α, β). In this paper, we establish bounds
 for the coefficients, and solve the Fekete-Szegő problem, for the class K((λ,α,β). Furthermore, we obtain upper bounds for the first two
 Taylor-Maclaurin coefficients of the functions in the class KΣ (λ,α,β)


Influence of the bonding material of a diamond stick is investigated on honing performance. Three kinds of synthetic diamond sticks are used, that is, a metal bonded stick, a resinoid one and a vitrified one. For the metal bonded stick its bending strength is changed to find out the suitable bonding strength. Workpieces are alumina Al2O3, silicon nitride Si3N4 and silicon carbide SiC, which are sintered under atmospheric pressure. The results are as follows. The metal bonded diamond stick is most suitable for the effective honing of these three ceramics. In this stick, there is an advisable value of bending strength σb to get high productivity, namely, 120-140 MPa for Al2O3 and 80-100 MPa for Si3N4 and SiC honing, and these are less than the ordinary value 200 MPa at metal honing. This comes from necessity of creating some new cutting edges in operating. Then, the diamond grain with high toughness is recommended. Using the vitrified bonded stick and the cubic boron nitride grain is not advisable.


We show that a space-time-varying medium can function as a front-end transceiver, i.e., an antenna-mixer-amplifier. Such a unique functionality is endowed by space-time surface waves associated with complex space-time wave vectors in a subluminal space-time medium. The proposed structure introduces pure frequency up- and down-conversions and with very weak undesired time harmonics. In contrast to other recently proposed space-time mixers, a large frequency up-/down conversion ratio, associated with gain is achievable. Furthermore, as the structure does not operate based on progressive energy transition between the space-time modulation and the incident wave, it possesses a subwavelength thickness (metasurface). Such a multi-functional, highly efficient and compact medium is expected to find various applications in modern wireless telecommunication systems.


This article examines ideas held by Humphry Davy (1778-1829) about permanence, progress, experiments and practical application regarding chemistry. Furthermore, it relates ideas held in his "Some experiments and observations on the colours used in painting by the Ancients" (1815), with those maintained in Elements of Chemical Philosophy (1812), as well as to cogitations from his last years, disclosed in Consolations in travel (1830). Lastly, it brings up evidence that H. Davy's study about the colors of the ancients influenced his proposals for Chemical Philosophy and the science of his age.


New-style urbanization is not only a major national strategy for today but also an inevitable trend of social development. It supplies a broad stage for the development of urban citizens' linguistic competence, which in turn constitutes the basis and motive force of the new-style urbanization and plays a pivotal role in its construction. Proceeding from linguistic competence is an effective measure for dealing with some of the thorny problems arising in the course of new-style urbanization, while new-style urbanization offers an opportunity for the improvement of urban citizens' linguistic competence.


Recognition of prior learning (RPL) have started well at the Finnish universities of applied sciences. However, there is not a uniform way for validation of prior learning. Savonia University of Applied Sciences (SUAS) participates in an international project about Recognition of Prior Learning (RELATE) which develops RPL practices. The project aims to promote permeability into higher education programs within Germany, Estonia and Finland, and to create a model of agreement between vocational education and training (VET) and higher education (HE) institutions for simplified RPL. The project has fostered international co-operation and produced data about the good practices from different countries to clarify RPL guidelines. VET and HE teachers have gained practical knowledge of both educations and are now better able to continue competence-based-curriculum and RPL procedures development. It has also generated simulation as a new authentic method for RPL.

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Aikaisemmin hankitun osaamisen tunnistaminen ja tunnustaminen (AHOT) on kaynnistynyt hyvin suomalaisissa ammattikorkeakouluissa. AHOT-prosessi kaipaa kuitenkin yhtenaisia linjauksia ja laadunvarmistusta. Savonia Ammattikorkeakoulu osallistuu kansainvaliseen Recognition of Prior Learning (RELATE) -hankkeeseen, jossa kehitetaan AHOT-kaytanteita. Hankkeen tavoitteena on edistaa ammatillisen koulutuksen ja korkeakoulutuksen osaamistavoitteiden lapinakyvyytta Saksassa, Virossa ja Suomessa. Organisaatioiden valinen yhteistyo on lujittanut kansainvalista yhteistyota ja tuottanut hyvia kaytanteita osaamisen arviointiin seka lisannyt osaamisperusteisten opetussuunnitelmien yhteista kehittamista toisen asteen ja ammattikorkeakoulujen valilla. Uusina osaamisen nayttomenetelmina on kokeiltu simulaatioita.


This Resource Is an article from Drug War Chronicle #343 about the many trials of Dr. Cecil Knox and office manager Beverly Boone who were ultimately acquitted, or had charges dismissed, of over 300 felony counts involving 'racketeering' and 'illegal' distribution of controlled substances. These cases are classic examples of vindictive, overzealous, and politically motivated attacks on pain doctors acting in good faith that are characteristic, unfortunately, of the War on Doctors, and which inexorably lead to a Chilling Effect on physicians who would prescribe opioid medications to treat chronic pain, and to the Pain Crisis in America.


A 2-axis low G acceleration threshold switch with multi-folded beams and buffering springs is presented in this paper. The multi-folded beams at four corners which anchored on the substrate permit the proof-mass move in both X and Y axis. The buffering springs contact the proof-mass and one electrode aiming at extending the contact time when the switch is latched while protecting the switch against severe shock damage from intensive impact of the switch. The threshold acceleration of the switch is designed as 60G and will be fabricated by a two-mask silicon-on-glass process.


1. Summary When drilling operations are carried out offshore, debris from the drilling process is discharged to the sea. Parts of the discharge (particle matter and chemicals that are attached to the particles) will end up on the sea floor and thus impact on the sediment. A numerical model has been developed that is able to describe the environmental impact caused by the debris on the sea floor. A bottom sediment module has been developed as a part of a more comprehensive model that is able to simulate the fate and associated environmental risks caused by the discharge of drill cuttings and mud both for the water column and the sediment. The deposit may cause different types of impact: The coverage of the debris on the sea floor may cause burial effects. The grain size of the deposit may cause a change in characteristic (median) grain size of the sediment that may favor other species on that location on the expense of the natural habitat (effects of adding "exotic sediment"). Chemicals that attach on the particles that are depositing may have toxic effects on the biota on the sea floor. Biodegradation of the added chemicals attached to the depositing particles (cuttings, barite, ..) may cause oxygen depletion in the sediment layer. The sediment impact model developed is able to describe the features listed above. The paper explains the method applied to describe the impact (by use of "diagenetic equations" for the sediment) and the associated environmental risks. An example calculation is also included. The method presented in this paper is developed as a part of the ERMS (= Environmental Risk Management System) project. This project is aimed at developing tools for reducing environmental impacts caused by discharges to sea from offshore activities in a cost effective manner. Details of the model presented here are extracted from the ERMS project report No. 18 on the model documentation (SINTEF 2006a).


A new type of foam glass with lightweight,thermal insulation,heat isolation,fire proof and water proof was developed by utilizing magnesium-removal boron mud and cullet as raw material.Some factors of influence on performance of the new type foam glass were discussed,such as sintering temperature and time,foaming temperature and time,content of foaming agent and molding pressure.The test result shows that under conditions of sintering temperature 690 ℃,sintering time 30 min,foaming temperature 840 ℃,foaming time 16 min,content of forming agent 10% and molding pressure 3~5 MPa the excellent foam glass with uniform pore can be produced and all properties meet the requirement of national standard JC/T 647—2005.


Objective
To evaluate the quality of red blood cell suspension and platelet concentrate separated and prepared from whole blood stored at 22℃ for 24 h.

Methods
From May 2014 to February 2015, a total of 60 voluntary blood donors who were recruited by Maoming Central Blood Station of Guangdong Province were included into this study, using simple random sampling method. The inclusion criterion for subjects was that the physical examination and related hematology tests results of all blood donors before blood donation met the relevant regulations in the Whole Blood and Blood Component Donor Selection Requirements (GB18467-2011). All the 60 donors were randomly divided into study group (n=30) and control group (n=30). A total of 60 bags of whole blood (400 mL) were collected from the blood donors in the two groups, using quintuple blood collection bags. In the study group, the whole blood was stored and transported at 22 ℃, and prepared into red blood cell suspension and platelet concentrate 24 h after blood collection. In the control group, the whole blood was also stored and transported at 22 ℃, and prepared into red blood cell suspension and platelet concentrate within 8 h after blood collection. The preparation of red blood cell suspension and platelet concentrate in both groups was conducted by the buffy coat method. Red blood cell suspension was stored at 4 ℃ until the end of the storage period (35 d after preparation), and its sterility test was using Bact/ALERT full-automatic microbial detection system. Moreover, red blood cell count, hematocrit (HCT), hemoglobin (Hb) level, free hemoglobin (FHb) level, hemolytic ratio at the end of the storage period, and K+ , Na+ and Cl- concentrations in red blood cell suspension were compared between the study group and control group. Also, platelet concentrate was stored at 22 ℃ until the end of the storage period (5 d after preparation), and its sterilty test was using Bact/ALERT full-automatic microbial detection system. Additionally, platelet content, red cell volume, FHb level, pH value at the end of the storage period, adhesion rate, aggregation rate, and K+ , Na+ and Cl- concentrations in platelet concentrate were compared between the study group and control group.

Results
① In the study group and the control group, there was no bacterial growth found in red blood cell suspension 35 d after storage, and in platelet concentrate 5 d after storage. ② In the red blood cell suspension of both groups 35 d after storage, all test results of HCT, Hb level and hemolytic ratio at the end of the storage period met the relevant requirements in Quality Requirements for Whole Blood and Blood Components (GB18469-2012). There were no significant differences comparisons of red blood cell count, HCT, level of Hb, level of FHb, hemolytic ratio at the end of the storage period, and K+ , Na+ and Cl- concentrations in the red blood cell suspension of both groups (t=0.55, 0.51, 1.18, 0.48, 0.72, 2.86, 2.07, 2.40; P>0.05). ③ In the platelet concentrate of both groups 5 d after storage, all test results of platelet content, red cell volume and pH value at the end of the storage period met the relevant requirements in Quality Requirements for Whole Blood and Blood Components (GB18469-2012). There were no significant differences comparisons of platelet content, red cell volume, level of FHb, platelet adhesion rate, platelet aggregation rate, K+ , Na+ and Cl- concentrations, and pH value in the platelet concentrate of both groups (t=0.17, 0.16, 0.56, 2.43, 0.36, 2.50, 1.85, 1.75, 0.32; P>0.05).

Conclusions
The quality of the red blood cell suspension and platelet concentrate prepared by whole blood stored at 22 ℃ for 24 h met national standards. Therefore, the separation and preparation of red blood cell suspension and platelet concentrate using whole blood stored at 22 ℃ overnight is feasible.

Key words:
Blood storage; Blood component removal; Red blood cell; Platelet; Quality control


ABSTRACT We test for the existence of Favourite-Longshot Bias (FLB) in tennis betting exchanges. Despite these being order-driven markets, with no direct participation from bookmakers, we have found very similar results to those obtained by Lahvička (2014) for bookmakers' betting markets: the bias is stronger in matches between lower-ranked players, in later round matches and in high profile tournaments. This suggests that bookmakers' adjustments to respond to informed betting are not the main driver of FLB. The varying magnitude of the bias across different types of event in the main market also weakens arguments linking FLB to gamblers' risk preferences, and suggests the need to consider the microstructure features of the market together with the cognitive biases highlighted in the behavioural finance literature.


Kuhn maintains that what marks the transition to a science is the ability to carry out 'normal' science—a practice he characterizes as abandoning the kind of testing that Popper lauds as the hallmark of science. Examining Kuhn's own contrast with Popper, I propose to recast Kuhnian normal science. Thus recast, it is seen to consist of severe and reliable tests of low-level experimental hypotheses (normal tests) and is, indeed, the place to look to demarcate science. While thereby vindicating Kuhn on demarcation, my recasting of normal science is seen to tell against Kuhn's view of revolutionary science.


Despite a similar beneficial effect on blood-pressure lowering observed with ACEIs and ARBs, several clinical trials and meta-analyses have reported higher cardiovascular mortality and lower protection against myocardial infarction with ARBs when compared to ACEIs. The European guidelines for the management of coronary syndromes and European guidelines on diabetes recommend using ARBs in patients who are intolerant to ACEIs. We reviewed the main pharmacological differences between ACEIs and ARBs which could provide insights into the differences in the cardiac protection offered by these two drug classes. The effect of ACEIs on the tissue and plasma levels of bradykinin and on nitric oxide production and bioavailability is specific to the mechanism of action of ACEIs; it could account for the different effects of ACEIs and ARBs on endothelial function, atherogenesis and fibrinolysis. Moreover, chronic blockade of AT1 receptors by ARBs induces a significant and permanent increase in plasma angiotensin II and an over-stimulation of its still available receptors. In animal models, AT4 receptors have vasoconstrictive, proliferative and inflammatory effects. Moreover, in models with kidney damage, atherosclerosis, and/or senescence, activation of AT2 receptors could have deleterious fibrotic, vasoconstrictive and hypertrophic effects. seems prudent and reasonable to reserve the use of ARBs for patients who have presented an intolerance to ACE inhibitors.


The article presents the author's work on the legislative regulation of the formation of healthcare competencies of the adult population in the USA. It has been studied that US lawmakers attach great importance to the outlined problem, which is determined by the large number of legislative acts and the diversity of their direction. The work presents relevant legislative documents and defines their essence. The analysis of the laws adopted by the US Congress on the health care of the adult population made it possible to distinguish 4 directions: Educational component; Improving the activity of medical provision; Support and preservation of personal health; Development of a network of health facilities and sports clubs. The methodological basis of the research is a complex search, analysis, synthesis of regulatory documents and the legal framework of the USA; justification of leading principles and functions; formation of generalized conclusions, identification of rational and practically valuable material. Therefore, the purpose of the article is to analyze the laws adopted by the US Senate and House of Representatives regarding the formation of healthcare competencies of the adult population and borrowing positive experience regarding the possibility of further application in the legislative acts of Ukraine. It is concluded that recognition of the need to ensure the formation of healthcare competencies of the adult population in the USA is being actively resolved at the legislative level. Legal initiatives set out in normative acts on the formation of healthcare competencies of the adult population are aimed at supporting and improving the level of health of the individual, the family, and as a result, ensuring the prosperity of the state in general. We have identified 4 main areas of activity of the US Congress regarding the healthcare of the adult population. We consider it appropriate to borrow the positive experience of the possibility of further application of the main directions in legislative acts and state programs of Ukraine.


Let X be a compac t Hausdorf f space and C (X) the a lgebra of all cont inuous complexva lued funct ions on X. Le t A be a un i fo rmly closed complex l inear suba lgebra of C(X). Our in te res t centers a b o u t such a lgebras A which are m a x i m a l among all p roper closed subMgebras of C(X). I n th is pape r we ga the r toge ther most of the known facts concerning m a x i m a l algebras, give some new results , and some new proofs of known theorems. A ma jo r mo t iva t i on for the s t u d y of max ima l a lgebras s tems f rom an a t t e m p t to general ize the S tone-Weiers t rass app rox ima t io n theorem to non-se l f -adjo in t algebras. This theorem s ta tes t h a t if A is a se l f -adjoint closed subalgebra of C(X) (lEA impl ies lEA), and if A separa tes poin ts and conta ins the cons tan t funct ion 1, t hen A = C(X). See [11; p. 8] for a proof. This resul t can be r e s t a t ed as follows: (i) eve ry p roper se l f -adjoint closed a lgebra A is con ta ined in a se l f -adjoint max ima l a lgebra and (ii) the se l f -adjoint max imM algebras, B, are of two kinds; e i ther B = [/EC(X), /(Xo)=0] for a f ixed xoEX, or B = [ /EC(X) ; /(xl) =/(x2) ] for f ixed xl,x 2 EX. The condit ion, A conta ins the funct ion 1, says t h a t A is no t in a m a x i m a l a lgebra of the f irst k ind. The condit ion, A separa tes points , says t h a t A is no t in a max ima l a lgebra of the second kind. Thus A is no t conta ined in any self -adjoint max ima l a lgebra and consequent ly , f rom (i), A is no t a p roper subalgebra , i.e., A = C(X). A ref inement of the S tone-Weiers t rass theorem classifies all se l f -adjoin t closed subMgebras of C (X) and says t h a t such an a lgebra A is the a lgebra of all cont inuous funct ions on an ident i f ica t ion space of X, wi th the common zeros of the funct ions in A deleted. This resul t can be r e in te rp re ted as saying t h a t A is the in tersec t ion of the selfad jo in t maximM algebras which conta in it. Le t us drop the self-adjointness condi t ion on A. One migh t now hope t h a t the w a y to general ize the S tone-Weiers t rass theorem would be to show t h a t (i) holds (with self-


Background: Nonadherence to antiretroviral therapy (ART) may encourage the development of resistance to antiretroviral drugs (ARVs). Poor adherence is known to be associated with ART failure which could compromise the benefits of ART in children. Therefore, it is important to identify the reasons why children on ART may fail to take their ARVs. In this study, we described the characteristics of human immunodeficiency virus-1 (HIV-1) infected children with ART nonadherence as well as the reasons for their nonadherence. Methodology: A retrospective cohort study in which data on 580 HIV-1 infected children enrolled on ART between February 2006 and December 2010 at the pediatric HIV clinic of the Jos University Teaching Hospital, Jos, was analyzed. Subjects were aged 2 months to 15 years. Information on adherence was obtained by child or caregiver self-report. They also had repeated adherence counseling during each clinic follow-up visit and were taught the use of alarm clocks daily for reminding them of when the next ARV dose will be due. Results: There were 30 (5.2%) children with non-adherence to ART. Among children with nonadherence, majority were: Children aged 1-10 years (76.7%), males (53.3%) and did not know their diagnosis of HIV (90.9%). The odds of nonadherence was two times higher among children who failed first-line ART compared with those who did not (odds ratio [95% confidence interval], 2.28 [1.03-5.02], P = 0.04). The most common reason for nonadherence was: Forgot to take medications (46.7%). Conclusion: The low rate of nonadherence to ART in this study could be attributed to repeated adherence counseling during each clinic follow-up visit and the use of alarm clocks daily for reminders on when the next ARV dose will be due.


Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA‐DR*0401 and *0402, using mice expressing HLA‐DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship between peptide/HLA‐DR4 kinetic stability and immunogenicity. Experiments were performed at endosomal pH (5.5) and at cell surface pH (7), in the absence and presence of soluble recombinant HLA‐DM (sDM). All (4/4) immunodominant peptide/HLA‐DR complexes exhibit dissociation half‐times of 1 h to several days. In contrast, most (3/4) non‐immunodominant complexes dissociate with half‐times <30 min under at least one of these conditions. Interestingly, a complex which is stable except in the presence of HLA‐DM at pH 5.5 is immunogenic only following peptide immunization, while a complex which is stable at acidic but not at neutral pH, is non‐immunogenic following either whole protein or peptide immunization. These data indicate that kinetic stability of peptide/MHC complexes in vivo is a key determinant of immunogenicity.


While this sign appears to be made with stucco, it is actually made of a polyurethane foam fabrication with a hard coat shell and is more durable than stucco as well as making it resistant to rot, termites & moisture. This monument was custom made with...


This paper implements a VLSI based Adaptive noise canceller (ANC) using Least Mean-Square (LMS) and Normalized Least Mean-Square (NLMS). Adaptive filters are capable of adapting their filter coefficients as per the variations in characteristics of input signal and noise to achieve a noise free signal. These algorithms have been implemented on Digital Signal Processor. Platform used for implementation of algorithms is DSP processor TMS320C6713. KeywordsANC; LMS; NLMS; DSP Processor


Post‐translational modifications (PTMs) are known to regulate biological processes by controlling protein function. The effect of a PTM on protein function depends critically on the position and the number of modifications. While there are convenient methods available to qualitatively examine modifications like phosphorylation, glycosylation, acetylation and methylation, methods available for their quantitative assessment are cumbersome. We have developed a new tool that allows quantitation of the number of phosphorylation events in proteins with ease. The "ProteoMod" tool depends on shifts in the isoelectric points of proteins upon post‐translational change. The extent of shift exhibited upon phosphorylation is algorithmically converted into the number of phosphorylations conferred. The validity of ProteoMod was confirmed by examining proteins with previously known number of phosphorylations. The list of proteins examined included HSP27, HSP70 and tumor suppressor p53. The approach can also be applied to estimate modifications like acetylation, methylation and sialylation in proteins. We analyzed shifts in isoelectric points due to sialylation events in N‐glycoproteins. Using influenza hemagglutinin we show that shifts in isoelectric points correlate with intracellular distribution of this model membrane protein. In addition to extending the application of two dimensional gel electrophoresis to quantitate modifications, our study also highlights its potential use in cell biology.


A hybrid power train system, which uses an electric machine to balance fluctuations of a load, is a practicable method to improve the efficiency of hydraulic excavators. To realize fast charge and discharge, ultra-capacitors are applied to a hybrid hydraulic excavator (HHE), which will cause the direct current (dc) supply voltage to change in a wide range. When the voltage of the ultra-capacitor varies, the output torque of the electric machine will be affected. In this paper, an interior permanent magnet synchronous machine (IPMSM) is employed in the HHE. When the dc supply voltage is low, the output torque of the IPMSM will drop and cannot balance fluctuations of the load adequately. To improve the control performance of the IPMSM output torque, a novel high-performance control strategy based on a vector control is proposed for the IPMSM to reduce the influence from the dc voltage. The mutual influence between the torque of the IPMSM and the dc voltage is analyzed. The novel high-performance control strategy for the IPMSM is introduced. To verify the effectiveness of the novel control strategy for the IPMSM, simulations and experiments are carried out. The results show that the proposed control strategy can improve the control performance of the IPMSM.


High energy consumption of conventional memory modules (e.g., DRAMs) hinders the further improvement of large-scale graph processing's energy efficiency. The emerging resistive random-access memory (ReRAM) has shown great potential in providing an energy-efficient memory module. However, the performance of ReRAMs suffers from data access patterns with poor locality and large amounts of written data, which are common in graph processing. In this paper, we propose HyVE, a Hybrid Vertex-Edge memory hierarchy for energy-efficient graph processing. In HyVE, we avoid random access and data written to ReRAM modules. HyVE can reduce memory energy consumption by 86.17 percent compared with conventional memory systems. We have also proposed data sharing and bank-level power-gating schemes, which improve the energy efficiency by 1.60x and 1.53x. By analyzing the graph processing model on ReRAMs, we show that ReRAMs are good for read-intensive operations in graph processing (e.g., reading edges), while ReRAM crossbars are not suitable for processing edges because of heavy writing overheads. Our evaluations show that the optimized design achieves two orders of magnitude and 5.90x energy efficiency improvement compared with the CPU-based and conventional memory hierarchy based designs, respectively. Moreover, HyVE achieves 2.83x energy reduction compared with the previous ReRAM-based graph processing architecture.


Orchestrating the success of underprepared college students is a major area of focus for many post-secondary learning institutions. One-to-one tutoring is the support service most often provided to these students. However, the effectiveness of tutoring as an intervention is controversial. Some see tutoring as supportive of student learning. Others see tutoring as ineffective, inefficient, and even harmful. Still others report that tutoring works under certain conditions but not under other conditions or with specific populations of students. This literature review was designed to critically review the research on college tutoring practices and clarify the efficacy issue and outcomes related to college tutoring programs.


The cerebral neocortex is an especially intriguing part of the nervous sys tem, partly because of its involvement in complex perceptual and cognitive functions, and partly because its relatively uniform histological structure belies the great diversity of roles it performs. The most thoroughly studied cortical regions have been the various sensory areas; of these the best understood are the visual areas, particularly the striate area, or primary visual cortex. One advantage associated with studying the visual system is the ease with which functional properties of neurons can be analyzed using a wide variety of patterned visual stimuli. Another


The present invention relates to a sinus balloon inflation catheter surgical navigation system. Sinus balloon inflation catheter surgical navigation system related to an example of the present invention provides a catheter surgical navigation system for the treatment of sinus, the catheter containing the expanded tube and the cleaning tube, and comprises a distal section and a proximal section; Located at the distal section of the catheter, an inflatable balloon connected to the inflation tube (balloon); And it located at the distal end of the catheter, irrigation tip including a tip opening connected to the washing tube; EM marker that is located between the balloon and the tip opening portion generates a magnetic field signal; Using the magnetic field signal tracking unit to determine location information of the marker EM; And a controller for matching the position of the marker in the EM pictures of the previously stored sinus using the location information; may include.


We isolated seven additional polymorphic microsatellites from the crown-of-thorns starfish, Acanthaster planci. These loci provide one class of highly variable genetic markers, as the number of alleles ranged from 5 to 13 and the observed and expected heterozygosities ranged from 0.083 to 0.957 and from 0.082 to 0.872, respectively. After Mann-Whitney test, there was no significant difference in the number of alleles, the PCR efficiency, and the observed and expected heterozygosities between the newly developed 7 markers and the previously reported markers. We consider that these loci are potentially useful for detailing the genetic structure and gene flow among A. planci populations.


Computers have swept every industry in the nation due to their practicality, consistent processing, and ease of modification. Today I hope to show you the economic, consistent, and adaptable advantages of this new state of the art in kiln drying. We are in business to turn a profit and try to do so by cost cutting, high production, and higher grade recovery. Few people have studied the entire cost of drying, but we all recognize that degrade, overdry, redry, and steam all add up to big money. Computers can not solve poor maintenance or poor kilns, but it will control very precisely by EMC, wood moisture, or hours. Controlling by wood MC or EMC of the kiln can increase grade recovery by maintaining conditions in the kiln which facilitate continuous drying. If the kiln is set for 12 hours of drying at a 20°F spread and the lumber is dry in 8 hours, those 4 hours could have been saved, and reduced production time. Hence, when the computer senses inefficient drying, it responds by stepping up the drying rate. Redry is reduced by in-kiln monitoring of MC. Thus, the computer will consistently and immediately respond to lumber conditions in effort to preserve the load while drying as fast as possible. So, let's suppose that we purchase a computer which has been designed to control a kiln. It usually has blinking lights, switches, and a snazzy control panel, and the Hildebrand 8000 is no exception. But inside is a carefully controlled set of electronic hardware suitable for the job. What does all of that do? Due to the complex things that computers do, most of us think that it is too complex to understand, but a computer is a device which uses a simple, organized approach to solving tasks. It "thinks" just like we do. We use our five senses to detect our environment: sight, smell, touch, hearing, and taste. Our brain needs these as inputs. The brain then goes to our memory to recall past experiences and interpret the inputs. The brain then decides how to react and sends a signal to your body parts to solve the situation. Your computer does the same things in solving kiln situations. During drying, the computer receives continual messages from the kiln about its environment. These inputs include: wet and dry bulbs, MC probes, and special instructions. Then the computer consults memory about its experiences like schedule, steam pressure, valve rates, charge history and programming steps. These will cause the computer to interpret and respond to the conditions. If the wet bulb depression is growing too fast, the computer consults its instructions and reacts accordingly. The response is a signal that Opens and closes valves for spray, heat, and vent control. These are outputs. And, like your


We provide two methods to compute the largest subset of a set of observations that is consistent with the Generalised Axiom of Revealed Preference. The algorithm provided by Houtman and Maks (1985) is not comput ationally feasible for larger data sets, while our methods are not limited in that respect. The first method is a variation of Gross and Kaiser's (1996) approximate algorithm and is only applicable for two-dimensional data sets, but it is very fast and easy to implement. The second method is a mixed-integer linear programming approach that is slightly more involved but still fast and not limited by the dimension of the data set.


Information professionals are often called upon to participate in an organization's competitive intelligence program, and they do so in a variety of capacities, playing key roles in the development and maintenance of the process. While they help firms develop effective competitive strategies, information professionals rarely apply the same evaluative techniques to their own operations. This article examines the basic elements of a competitive intelligence program as applied to a library/information center setting.


The article presents literature data demonstrating the presence of endothelial dysfunction in patients with polycystic ovary syndrome (PCOS) and explaining its origin. The expediency of endothelial dysfunction medical correction in patients planning pregnancy is reasoned. Provided the clinical experience of sulodexide use in patients with PCOS with the complicated pregnancy history.


The flow of central lymph in the rat was examined and its concentration of total proteins was determined. Experiments were performed both on healthy animals and on animals with experimentally induced pathological states. The following results were obtained: The flow of the lymph is increased in chronic liver damage, acute kidney damage and the malabsorption syndrome. On the other hand, lymph flow is decreased in fasting animals, and it is unaffected by acute liver damage. Total protein concentration was increased in fasting rats and in the group with acute liver damage, and on the contrary, it was decreased in the group with chronic damage, acute kidney damage, and malabsorption syndrome. The lymph flow or total protein concentration are not sex-dependent.


Operating heavy-duty hydraulic manipulators with a master-slave control system is very challenging to execute complex tasks in unstructured environments. In this paper, to improve the operational efficiency for performing repetitive tasks, we designed a dynamical guidance virtual fixture via learning from demonstration to assist the operation. A data fitting method is proposed by reconstituting the control vertexes to address the operation noises caused by response lag and oscillation tendency of hydraulic manipulators, such that a smooth nominal trajectory is obtained and used to generate the virtual fixture. Then, a pipe-constraint guidance virtual fixture is designed with multiple control modes to meet the demands of free and constraint motion. Comparative tests were carried out with a 3-DOF hydraulic manipulator to perform trajectory tracking tasks and movement within a limited space. Compared with no assistance, the results show that the average time of task completion can be reduced by over 50% with the proposed guidance virtual fixture. Besides, the mental pressure of the operator can be reduced since collision avoidance can be easily achieved.


Objective To discuss the clinical value of inverse hand - method when the usual method and position can not demonstracte the organs on the diseases clearly. Methods Six hundred and fifty patients whose organ imaging of diagnosis were not distinct had been examined by the inverse hand - method and compared with the positive results. Results The imaging of 630 in 650 patients (96.8 % ) were improved variously, Among them 546 were improved(84% ) greatly and 84 were improved slightly(12.9%) . Conclusion The inverse hand - method provides a convenient, precise diagnostic way to the cases which can not be showed clearly with the usual method and position.


The present invention provides compositions and methods for the modulation of normal or activated forms of the human ras gene expression. The invention in particular oligo to hybridize with the RNA or DNA derived from the ras gene of the human body provides a nucleotide oligonucleotide, and these oligonucleotides have the sufficient number of nucleotide units, and to recognize that such that the effective specific hybridization. The invention also provides oligonucleotide can specifically hybridize with the human H-ras, and Ki-ras oligonucleotide. Such oligonucleotides can be used for diagnostic purposes as well as for research purposes. In another aspect, the present invention the oligonucleotide using nucleotides also provides a method for the specific regulation of the modulation of ras gene expression in cells, tissues, and activated ras genes. In addition, there is a diagnosis, detection and treatment of diseases caused due to the activation of H-ras or Ki-ras gene method is disclosed.


INTRODUCTION: Obesity is a chronic disease that impairs health or exacerbates others comorbidities. Among the treatment options, bariatric surgery has shown effective and lasting results. However, patients may experience adverse effects, like gastric reflux, nausea, vomiting, dehydration, vitamin and mineral deficit, and thereby potentiate negative effects of oral manifestation, including dental erosion, caries, periodontal disease, alterations of saliva and oral mucosa. OBJECTIVES: Evaluate oral condition of Unified Health System (SUS) patients at the bariatric surgery service of Hospital Evangélico de Vila Velha (Brazil), analyzing DMFT index, PSR (Periodontal Screening and Recording), salivary pH and the self-perception of oral health. METHODS: An prospective, observational descriptive case series study, conducted in the dental clinic located at Universidade Vila Velha (Brazil), evaluated 24 patients subjected to bariatric surgery. Patients were included in the study after explanation, reading and signing of the Informed Consent Form. The data were collected by means of questionnaires on oral health perception, clinical examination and salivary collection. RESULTS: All evaluated patients had periodontal disease, besides a considerable amount of decayed teeth (7.86%), despite the alkaline pH registered in 83.3% of the sample. Furthermore, 83.3% of the patients stated they did not receive oral hygiene orientation before the gastroplasty. CONCLUSION: The oral health of the participants was unsatisfactory due to the high rates of periodontitis and decayed teeth, even with alkaline salivary pH. Self-perception of oral health does not correspond to the results obtained in the clinical examination. Thus, the inclusion of dentistry in the multidisciplinary team can contribute to health and care of bariatric surgery patients.


An overview of the field of modular selfreconfigurable robots is presented. The background and objectives of the field are reviewed, along with a description of several successful designs, categorized by actuator type. Control algorithms are mentioned, along with a method for evaluating complexity of multi-robot control. Several challenges to miniaturization are discussed, focusing on power and actuation requirements for large networks of modular robots.


—Electroencephalogram (EEG) has been one of the common neuromonitoring modalities for real-world brain-computer interfaces (BCIs) because of its non-invasiveness, low cost, and high temporal resolution. Recently, light-weight and portable EEG wearable devices based on low-density montages have increased the convenience and usability of BCI applications. However, loss of EEG decoding performance is often inevitable due to reduced number of electrodes and coverage of scalp regions of a low-density EEG montage. To address this issue, we introduce knowledge distillation (KD), a learning mechanism developed for transferring knowledge/information between neural network models, to enhance the performance of low-density EEG decoding. Our framework includes a newly proposed similarity-keeping (SK) teacher-student KD scheme that encourages a low-density EEG student model to acquire the inter-sample similarity as in a pre-trained teacher model trained on high-density EEG data. The experimental results validate that our SK-KD framework consistently improves motor-imagery EEG decoding accuracy when number of electrodes decreases for the input EEG data. For both common low-density headphone-like and headband-like montages, our method outperforms state-of-the-art KD methods across various EEG decoding model architectures. As the first KD scheme developed for enhancing EEG decoding, we foresee the proposed SK-KD framework to facilitate the practicality of low-density EEG- based BCI in real-world applications. Codes are available at https://github.com/CECNL/EEG-KD.


Abstract The structural, elastic, anisotropic, and lattice dynamical properties of cubic perovskite compounds XInO3 (X = K, Rb, and Cs) are investigated using first-principles calculations. Electronic band structures and state densities revealed that the electronic nature of the studied materials exhibited half-metallicity properties. The existence of O p–d states close to the Fermi level contributes to the half-metallic properties. Moreover, polycrystalline properties, such as bulk, Young, and shear moduli and Pugh and Poisson ratios, have been determined. As a result of these characteristics, the compounds under consideration exhibited ductility behavior. As far as is known, since this is the first study of XInO3 (X = K, Rb, and Cs) compounds, this work sheds light on future works.


T he Greeks, and especially Aristotle, made a distinction between two types of human activities: one type was called praxis or "doing" and the other was called poiesis or "making." The latter corresponds roughly to what we might call today (in ordinary, not academic, discourse) "utilitarian" activity, activity aimed at the production of some object or state of affairs external to itself. The former does not have an easy moder translation, a fact that says as much about the moder period as about the Greek. Making a musical instrument, like a flute, would be poiesis. The criteria for assessing the activity reside in its product. If it is a good flute, the activity was successful; if not, not. Playing the flute would be praxis, and the criteria for assesssing the playing would be harder to specify. Here the criteria are somehow internal to the activity.' The relevance of this division between types of human activities to the present topic, moral psychology and the teaching of ethics, will become clearer, I hope, as I proceed. A first glimpse at that relevance can be had, however, simply by asking whether the activity of teaching ethics, especially in "applied" contexts such as business and professional education, leans more toward poiesis or more toward praxis. A careful answer to the question would doubtless allow for elements of both, i.e., teaching ethics is both "doing" and "making." But the burden of my remarks will be that the salient element is praxis, and that this determination is not trivial when we go on to ask about the place of psychological research in the enterprise. Oversimply, if the teacher of ethics is not dominantly engaged in a kind of "making" activity vis-a-vis those who participate in ethics "programs," then trying to measure the success of such programs by social scientific instruments becomes less appropriate. I am aware that in taking such a position I am letting myself in for some stiff cross-examinatioh from those who will interpret my remarks as antiscientific or as merely reaffirming the evils of indoctrination. The careful reader will appreciate that the matter is more complex. As I read it, James Rest's discussion of moral psychology and the teaching of ethics addresses not one but several broad issues. And because the issues are distinct, it behooves us at the outset to tease them apart for the sake of clarity. For one thing, Rest is providing a useful set of cate-


In this article we indicate our research results realized with the first year students of the Gymnasium in Bilíkova Street in Bratislava. The analysis of selected questions from questionnaires achieved that online excursions provided the students in the classroom with the opportunity to really identify with the activities performed by their classmates in the terrain, but especially with the opportunity to search for and process the information provided by the students in the terrain.


diseases of the small intestine in childhood louduk diseases of the small intestine in childhood fbtest diseases of the small intestine in childhood ajkp diseases of the small intestine in childhood mrtune diseases of the small intestine in childhood safn small intestinal length: factor essential for adaptation gut disorders of carbohydrate absorption in childhood topic: diseases of the digestive system celiac disease napa valley college facts and fallacies about digestive diseases trianglegi adhering to the surface of the gastric mucosa. are a major digestive system disorders missouri western state university microbial diseases of the digestive system taft college disease ofthe bowel in childhood j. a. walker-smith* treatment of inflammatory bowel disease in childhood: best gastroesophageal reflux what is gastroesophageal reflux? facts and fallacies about digestive diseases pediatric and adolescent gastrointestinal motility & pain string probes for devastating childhood digestive disease escherichia coli contacting microvilli on the surface of disorders of intestinal rotation and ?xation (''malrotation'') diagnosis and management of inflammatory bowel disease in what people with inflammatory bowel disease need to know adult diseases seen in childhood-cmh.ppt [read-only] normal oxidative phosphorylation in intestinal smooth inflamatory bowel brochure gregoryshannonmd irritable bowel syndrome (ibs): introduction trusted health information nih treatment of intestinal protozoan infections in children celiac disease homepage american association of family national digestive diseases information clearinghouse pediatric and adolescent gastrointestinal motility & pain crohn's disease of the small intestine: clinical course pediatric dermatology: bullous disease gas in the digestive tract trianglegi texas medical center digestive diseases center media.bcm chapter 18 gastrointestinal and ccctc home treatment of intestinal protozoan infections in children chapter 6: digestive system respiratorytherapyfiles the development of intestinal microbiota in childhood and


The authors introduce a new MMIC bandpass filter element, with triple-coupled CPW (TCC) lines, realising 3rd-order filter sections. By cascading them, the order of the filters will be increased by two. The proposed TCC lines are the smallest passive uniplanar third-order MMIC filter element reported to date.


The 220 kV electrical network short-circuit current level enhances quickly along with unceasing enhancement of electrical network structure,open-loop operation mode must be carried out gradually to lower the 220 kV electrical network short-circuit current level.But in the process of electrical network open-loop it often contradicts with some planned electrical network projects.This paper describes the fundamental principles as well as the main method of open-loop.Taking Zhengzhou 500 kV/220 kV electromagnetic ring for example,in accordance with its present situation and long-term network planning,open-loop operation is progressively implemented and the rationality of Zhengzhou long-term network plan has been simultaneously verfied.This paper puts forward the idea of using the open-loop planning studies to verify the rationality of electrical network planning,which not only unifies the network planning and open-loop planning rationally to guide the development of electrical network,but also avoids unnecessary construction to save investment.


This study was to discuss the neuromuscular dominating mode of lower limb muscles in the vertical vibration and combination vibration training through electromyography test at squat.The results showed that the two forms vibration stimuli could increase muscular discharge,but coordination mode of activation during multi-dimensional combination vibration was superior to single-dimensional vertical vibration.It provides us theoretical basis for understanding the function of vibration training and its usage correctly in the future.


Objective. Our study aims to analyze the indications for therapeutic abortion and to discuss the legal implications of this procedure in Romania. Methods. We performed a retrospective cohort study of singleton and as well as twin pregnancies terminated for therapeutic reasons between 2014 and 2016 in "Bucur" Maternity, Bucharest. The patients that were admitted in our clinic were cared by obstetrics-gynecology specialists, and interdisciplinary consults were requested if needed. We conducted blood tests, fetal morphology scans, amniocentesis as well as a complete survey of the patients' medical history, and the diagnosis was made according to the findings by a team of OG experts. The patients were given full access to information and guidance according to ACOG guidelines. The decision to terminate the pregnancy was made after undergoing prenatal and psychological counselling and after the patient was informed about the risks and complications of the procedure. Results. A total of therapeutic abortions were conducted in our clinic from 2014-2016. In 65% of cases the causes were fetal, in 20% were maternal and in 15% maternal and fetal causes were reported. The mean maternal age vas 31.65 years, for maternal indications the means was 36.25 years and for fetal indications-plurimalformative syndrome diagnosed fetuses 27.57 years of age. 80% of the women were multiparous, with 55% non-smokers. The psychyatric maternal pathology dominated the maternal indications (4/7), and regarding the fetus related indications 7/13 were diagnosed with plurimalformative syndrome, 3 associated with T21 diagnosis. Regarding the procedure 35% were uterine curettages, 50% induced oxytocin births, there was one caesarean operation and one total histerectomy. Conclusions. The most frequent reasons for therapeutic abortion were fetal anomalies. Considering the legal, ethical and medical implications the decision of pregnancy termination should follow only an accurate diagnosis, specialised team counseling and thoroughly informed couple. Legislation must differentiate therapeutic abortion from the challenge of premature delivery, therapeutic abortion not being "in the fetal interest" while premature elective delivery may be maternal but also fetal.


We demonstrate that, for a two-dimensional, steady, solitary wave profile, a flow of constant vorticity beneath the wave must likewise be steady and two-dimensional, and the vorticity will point in the direction orthogonal to that of wave propagation. Constant vorticity is the hallmark of a harmonic velocity field, and the simplified vorticity equation is used along with maximum principles to derive the results.


Engineers are frequently faced with the challenge of developing applications to meet a wide range of requirements. Usually, these requirements are difficult to fulfill simultaneously. One example is finding a very fast, high voltage operational amplifier (op amp) with high output power and equally good characteristics in dc accuracy, noise, and distortion. Op amps combining all of these characteristics are rarely available on the market. However, it is possible to build such an amplifier yourself out of two individual amplifiers, creating a composite amplifier. When combining two op amps, the positive characteristics of each one can be incorporated. In this way, a higher bandwidth can be achieved compared to that of a single amplifier at the same gain.


Non-uniformity correction (NUC) is a standard procedure for infrared (IR) cameras. The effect of lens temperature, however, is often ignored during the implementation of a NUC. Ignoring the effect of temperature is acceptable if the lens temperature is at much lower than ambient temperature, whose irradiance onto the focal plane array (FPA) is much less than that of the scene. Ignoring the effect of temperature is also acceptable if the lens temperature during the calibration for NUC is the same as that during the scene collection. The change of the lens temperature in between the calibration for NUC and the scene collection, however, affects the performance. Such degradation in image quality is presented by the frames taken by a mid-wave infrared (MWIR) camera. An empirical law is established to mitigate the effect of lens temperature, which offers various options for NUC. As an example, we propose a four-point NUC that mitigates the effect of the lens temperature. We demonstrate its usefulness by applying it to the frames taken at various lens temperatures. The results are satisfactory.


The incidence of gastritis is currently increasing, and people's poor diets are one of the contributing factors. Many people who often skip breakfast also often drink coffee and prefer fast food such as junk food and spicy food. The purpose of this study was to determine the relationship between diet and the incidence of gastritis in patients at the Badegan Health Center, Ponorogo Regency. This research is quantitative and includes correlation analysis, cross-sectional methodology, and quota sampling with a sample of 35 respondents. by using Fisher's Exact calculations to examine the relationship between diet and the incidence of gastritis at the Badegan Health Center, Ponorogo Regency. The results showed that 23 respondents (65.7%) had a good diet and 11 respondents (31.4%) of 35 respondents suffered from gastritis. The results of the Fisher Exact calculation with an alpha of 0.05 obtained a p-value of 0.002. Then Ho is rejected and H1 is accepted. It can be concluded that there is a relationship between diet and the incidence of gastritis in patients at the Badegan Health Center, Ponorogo Regency. To prevent gastritis, researchers advise patients at the Badegan Health Center to pay attention to, implement, and increase the intake of healthy foods and balanced nutrition.


The growing problem of the sector La Mariscal is the continuous loss of residential property due to the excessive concentration of trade and night attractions, which has generated the displacement of residents towards other areas of the city. Besides, La Mariscal is a centrality that is morphologically "isolated" because many of its roads are edges that do not allow exchanges whitin other areas. Therefore, the nineth semester workshop (AR0-960) focuses on densifying and connecting La Mariscal to restore the vitality. In addition, the important presence of eleven universities in this sector can not be ignored, which implies a great demand for temporary housing for foreign students who study at said universities. For this reason, a University Residence has been proposed for the present work, wich is located in the Santa Clara neighborhood between Ignacio de Veintimilla and Gral. Ulpiano Paez streets. This site is strategic due to its location near by the universities and to the fact that one of the objectives of the proposed Master Plan is to increase residentiality in this sector. This project has a hybridization with a coworking that complements the activities of the students and seeks to boost the active hours of the residence while trying to connect with the Julio Andrade park so that there is an integration and appropriation with this public space.


A nonsingular flow is quasigeodesic when all flow lines are efficient in measuring distances in relative homotopy classes. We analyze quasigeodesic Anosov flows in 3-manifolds which have negatively curved fundamental group. We prove that the lifts of the stable and unstable foliations to the universal cover are foliations with branching, that is, they have non-Hausdorff leaf space. Furthermore any branching is associated to freely homotopic closed orbits of the flow in the manifold and there are finitely many such branching leaves up to covering translations. Using this we prove that the limit sets of the stable and unstable leaves in the universal cover cannot be Jordan curves nor the whole sphere. Identifications of ideal points of leaves are also described using freely homotopic orbits. Finally, for any Anosov flow in such manifolds, we prove the existence of uncountably many (infinitely many of which are closed) Kquasigeodesic orbits for K big enough. The key tool is the analysis of freely homotopic closed orbits, which are completely characterized for general Anosov flows.


"A childhood of neglect, an early career spent in a dependent position at Moor Park (Temple's house), a life of suspense and disillusionment at court,…" David Nokes, a biographer of Swift. Swift's acquaintance with Temple sharpened his literary imagination even though there had been many debates on Swift's position in Temple's household. His publication of Temple's writings drew Swift towards literature and literary production rather than politics and political affairs. Had it not been for his being attracted to writing through Temple's works in his youth and his literary circle in his maturity, Swift seemed to have a great tendency to be either a mere political writer or a sole church member. However, politics and religious issues never disappeared from his literary career and Swift never vanished wholly from political and religious arena. Politics is believed to have had most of his literary imagination under its control and Swift sometimes let his political thoughts be at liberty which he had kept forcibly in balance with literature during his literary life. For several times, politics defeated poetry in the internal struggle in Swift's personality the outcomes of which were his Examiner, pamphlets of Swift and Steele, A Modest Proposal and finally Drapier but each time Swift's artistic handling of the situation made posterity to think of him as a writer rather than a politician. For David Nokes "His most successful political writings are not his histories, in which he tries to unravel the skein of state events with the authority of an insider, but his satires, which demonstrate that ministers of state are merely footmen on stilts."


In this paper, one considers the coupling of a Brinkman model and Stokes equations with jump embedded transmission conditions. In this model, one assumes that the viscosity in the porous region is very small. Then we derive a Wentzel–Kramers–Brillouin (WKB) expansion in power series of the square root of this small parameter for the velocity and the pressure which are solution of the transmission problem. This WKB expansion is justified rigorously by proving uniform errors estimates.


Patients with proximal deep vein thrombosis (DVT) are at high risk for postthrombotic syndrome (PTS), even if they receive systemic anticoagulation