We describe an atypical case of a young adult who had the acute onset of neuropsychiatric symptoms consistent with vitamin B12 deficiency despite a normal hematocrit, a normal MCV, a normal peripheral blood smear, a normal bone marrow biopsy, a normal Schilling test but abnormally low serum vitamin B12 levels. The patient responded quickly to parenteral vitamin B12 therapy but had mild residual symptoms at the time of his last clinic visit.


As part of its operation and maintenance of the ARPANET for the past twelve years, BBN has been asked to investigate a number of cases of degradation in network performance. This presentation discusses the practical methods and tools used to uncover and correct the causes of these service problems. A basic iterative method of hypothesis generation, experimental data gathering, and analysis is described. Emphasis is placed on the need for experienced network analysts to direct the performance investigation and for the availability of network programmers to provide special purpose modifications to the network node software in order to probe the causes of the traffic patterns under observation. Many typical sources of performance problems are described, a detailed list of the tools used by the analyst are given, and a list of basic techniques provided. Throughout the presentation specific examples from actual ARPANET performance studies are used to illustrate the points made.


Clusters of galaxies are the largest gravitationally‐bound system in the universe, and possible candidates of particle accelerator. The detection of diffuse radio emission, which is synchrotron emission caused by relativistic electrons, supports the scenario. The direct measurements by X‐ray/Gamma‐ray are important to clarify the non‐thermal view of clusters. We present the initial hard X‐ray research of galaxy clusters (especially for A3376) with Suzaku, which has excellent sensitivity in a few tens keV. GLAST will make X‐ray results be more valuable to discuss particle acceleration in galaxy clusters.


The Country Opinion Survey in Nigeria assists the World Bank Group (WBG) in gaining a better understanding of how stakeholders in Nigeria perceive the WBG. It provides the WBG with systematic feedback from national and local governments, multilateral/bilateral agencies, media, academia, the private sector, and civil society in Nigeria on 1) their views regarding the general environment in Nigeria; 2) their overall attitudes toward the WBG in Nigeria; 3) overall impressions of the WBG's effectiveness and results, knowledge work and activities, and communication and information sharing in Nigeria; and 4) their perceptions of the WBG's future role in Nigeria.


personally self-willed devising ' ( p. 70). In other words, liberals as Newman would define the term in the Apologia. Moreover, had Newman's closest friends in the Littlemore community not converted it is 'an open historical question' ( p. 102) whether Newman himself ever would have. This is strong stuff, but it is not necessary to accept every argument to recognise that Turner has produced an exceptionally fertile and thought-provoking interpretation of both John Henry Newman and his great work. It is tempting to say that it cannot be ignored by Newman scholars, but that is perhaps too optimistic. Better to say that it should not be ignored. As for the text, the editing is careful, the editorial interventions useful and unobtrusive, and the choice of the 1865 Longman edition (omitting the exchange with Kingsley) reasonable. Even those who threw the book across the room in a rage on reading the introduction will nevertheless have to use it for what it clearly is : the standard scholarly edition of a classic of Victorian literature.


This paper explores the future sustainability of farm animal veterinary practice in light of changes in both the farming and veterinary sectors. The paper makes a valuable contribution to the rural enterprise and veterinary business literatures, finding that future sustainability of farm animal veterinary practice is dependent on vets being prepared to change with their clients, develop supportive partnerships and create effective marketing strategies. We use our findings to propose a model for the future sustainability of farm animal veterinary practice. Given that the future of this sector depends on the stability and growth of the livestock industry, we provide context for our discussion by briefly reviewing the farm animal sector. The potential impact of the gender shift towards a predominately female veterinary profession is also considered. Some policy implications are discussed alongside avenues for future research.


Background and Purpose: The source of gastrointestinal bleeding in children is usually readily identifiable with a standard evaluation. Rarely, the source of bleeding is obscure and may be conditions such as intestinal duplication, Meckel's diverticulum, or Henoch-Schonlein purpura (HSP). Laparoscopy is an ideal modality to identify such obscure sources and may also allow definitive therapy at the time of evaluation. The authors describe their experience with this modality. Patients and Methods: In a 1-year period, 64 patients were evaluated for gastrointestinal bleeding. Laparoscopy was used for diagnosis and treatment when the source of bleeding could not be ascertained by physical examination and upper or lower tract endoscopy or both. Results: Upper tract endoscopy and colonoscopy failed to demonstrate a bleeding source in four patients. The source of bleeding was a Meckel's diverticulum in three patients. Two of these lesions were suspected preoperatively from Meckel's scans. The source of bleeding i...


The article considers the current issues of monetary circulation in Ukraine and the world in the context of global challenges related to the world financial crisis of 2008-2009, the coronavirus pandemic and the Russian-Ukrainian war. The purpose of the study is a comparative analysis of electronic money, both fiat and virtual, as non-fiat, regarding the possibilities of their transformation into mainstream, that is, to occupy their dominant position in the money circulation systems of Ukraine and the world. It is noted that virtual money is often also called cryptocurrencies, because it is based on the blockchain technology, which provides a cryptographic system for protecting information. It is emphasized that their main technological feature is the decentralized nature of the crypto network. This means that they are not emitted or controlled by the state, and therefore cannot belong to fiat money (as opposed to electronic). Both advantages and disadvantages of virtual money compared to electronic ones have been identified. The presence of such shortcomings in cryptocurrencies, as a significant energy consumption of mining coins, high market volatility, the presence of «bad actors» in crypto networks and the displacement of national currencies, acutely raises questions about their regulation. It is proposed to distinguish between the five models of regulation of cryptocurrencies: repressive (with their complete prohibition); conservative (with the possibility of their purchase and sale in crypto exchangers); liberal (with permits for most operations with them); legal turnover; permitting (with recognition as a means of payment on par with the dollar and other reserve currencies). It is noted that despite the significant restrictions, especially according to the demands of repressive and conservative regulatory models, the cryptosector is rapidly developing both in the world and in Ukraine. As a positive moment in the development of the cryptosector in Ukraine, it is noted that it is already «working» in support of Ukraine in the war with the russian federation. It is concluded that the mainstream of cash flow should be electronic money. Virtual money should not bypass their share in cash and become another reserve currency. Otherwise, it will give cartblanche to transnational capital and undermine the basis of the current world system – the division of the world into separate states.


CAR-T cell therapy against CD19 has changed the treatment landscape in relapsed/refractory (r/r) B-ALL. R/r T-ALL has a dismal prognosis, with an unmet need for effective targeted therapies. Several unique challenges mean that CAR-T cell therapy has yet to be successfully translated to T-ALL. Most strategies have targeted pan-T cell antigens (CD7, CD5) but these are limited by T cell aplasia and fratricide, requiring elimination of CAR-T antigen surface expression during manufacture. An ideal target would be exclusively or largely confined to the malignant T cell component but published examples of these (CD1a and TRBC1) are expressed in only minor T-ALL subsets.
 We previously showed that CD21 is expressed in a NOTCH-dependent manner in T-ALL (Leukemia. 2013, 27:650) and have developed it as a potential immunotherapy target, being primarily expressed on normal B cells, with minimal expression on mature T cells.
 70% of human T-ALL cell lines (9/16) expressed surface CD21 by flow cytometry (FACS), with a median antigen density in positive lines of 2545/cell. In primary T-ALL, 57% of presentation samples (n=58) expressed CD21 (median antigen density 1168/cell). 45% of relapse (n=11) and 20% of primary refractory cases (n=30) expressed CD21, with a similar antigen density to presentation samples. CD21 positivity varied by maturational stage, with highest expression in cortical T-ALL (80% of cases) followed by pre-T (72%), mature (67%), ETP (25%) and pro-T (17%).
 Healthy donor blood (n=14) showed CD21 expression limited to B cells and a low proportion (11%) of T cells (10-fold lower intensity v B cells, 316 antigens/cell). T cell CD21 expression was not up-regulated upon activation with CD3/CD28 antibodies (n=6) and was not associated with markers of differentiation/exhaustion.
 To target CD21, DNA gene-gun vaccination of rats with a plasmid encoding full-length CD21, followed by phage display was performed and multiple anti-CD21 scFvs isolated. These were cloned into 4-1BBζ CARs and expressed in primary T cells but failed to kill or secrete cytokines in response to CD21+ SupT1 cells.
 CD21 is a bulky molecule, with 15/16 sushi repeats in the extracellular domain. All isolated scFvs were found to bind membrane-distal domains. We hypothesized that ineffective signalling due to inadequate synapse formation was responsible for poor performance of anti-CD21 CAR-T, and that binders to membrane-proximal epitopes would signal more efficiently. We re-vaccinated rats with the first 5 sushi repeats of CD21 and generated a library of binders which bound CD21 at this membrane-proximal region.
 Multiple candidate binders expressed as CARs were functional, with cytotoxicity and interferon-γ secretion in response to CD21+ target cells. However, non-specific background cytokine secretion was seen against CD21 negative cells, and no IL-2 secretion was seen. Re-cloning binders into a fragment antigen binding (Fab)-CAR architecture yielded constructs capable of specific cytotoxicity, IFN-γ and IL2 secretion against a CD21+ cell line but not its CD21 negative counterpart (n=6). Our lead anti-CD21 candidate CAR specifically proliferated in vitro, without fratricide or premature exhaustion/ differentiation, and was active against low-density CD21-positive cell lines (n=3) and primary cells from 2 T-ALL patients. Improved functionality of Fab v scFv-based CAR was not driven by higher affinity binding or CAR surface expression.
 We tested anti-CD21 CAR in murine models of T-ALL. NSG mice were injected with SupT1-luciferase cells and treated with aCD19 or aCD21 CAR-T on day +5. At 2 weeks post treatment, markedly lower disease burden was seen in CD21 CAR-T v CD19 recipients by bioluminescence imaging (median radiance 71700 v 790000 p=0.0079). Further, we injected primary T-ALL blasts in another cohort, treating with aCD19 or aCD21 CAR-T on D+20. Serial bleeds from day 27 post CAR-T showed tumour control in aCD21 CAR treated mice (p=0.024) with an overall survival advantage (median OS 44 days vs undefined, HR = 19.8, p = 0.0069, n=4/group).
 In summary, we propose CD21 as a novel target for CAR-T cell therapy in T-ALL. Its expression is largely restricted to the malignant T cell compartment, overcoming issues with fratricide and on-target off-tumour effects seen in many T-ALL CAR-T strategies to date. Despite the complexity of the target, we have successfully generated an aCD21 CAR that is functional both in vitro and in vivo.

 Maciocia: Autolus: Current equity holder in publicly-traded company. Onuoha: Autolus: Ended employment in the past 24 months. Khwaja: Pfizer: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Jazz Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Astellas: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Abbvie: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Maciocia: Autolus: Current equity holder in publicly-traded company, Research Funding. Pule: Autolus: Current Employment, Current equity holder in publicly-traded company.


In the Greek mythology, the Chimera was a monstrous firebreathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal (usually depicted as a lion, with the head of a goat arising from its back, and a tail of snake). Homer's brief description in the Iliad is the earliest surviving literary reference. The term Chimera has come to describe any mythical or fictional animal with parts taken from various animals, or to describe anything composed of very disparate parts, or perceived as wildly imaginative, implausible, difficult to realize or utopian. Bellerophon was the hero who fought and killed the Chimera. When he arrived in Lycia, the Chimera was truly ferocious, and he could not harm the monster even while riding on Pegasus. He felt the heat of the breath the Chimera expelled, and was struck with an idea. He got a large block of lead and mounted it on his spear.
Then he flew head-on towards the Chimera, holding out the spear as far as he could. Before he broke off his attack, he managed to lodge the block of lead inside the Chimera's throat. The beast's firebreath melted the lead, and blocked its air passage. The Chimera suffocated, and Bellerophon returned victorious to King Iobates.
Percutaneous cardiovascular interventions are the cornerstone treatment of cardiovascular diseases. Antithrombotic therapy during and after these interventions
is fundamental to prevent ischemic recurrences, but has the risk to increase bleeding complications. To find the optimal strategy to prevent ischemia without affecting bleeding in all patients is matter of ongoing discussion and research, and probably remains a chimera. Like Bellerophon searching for and fighting with the Chimera, clinicians should be aware of the trade-off of both bleeding and ischemia and their impact on patients' health, thus searching for the optimal therapy which has not to face with a single animal (ischemia or bleeding), rather must account and balance for the effects on both these entities. In such a context, personalized medicine characterized by individualization of therapies patient-by-patient based on the individual risk/benefit profile appears to be a promising approach that clinicians might adopt to kill this nightmare.


INTRODUCTION Availability of efficient software to estimate the (co)variance components in linear mixed models is an essential prerequisite for estimation of genetic parameters for traits of interest in livestock improvement schemes. One of the oldest programs used for restricted maximum likelihood (REML) estimation is DR, originally written in 1987 and updated until 2000 (Meyer, 1988, 1998). While reliable (and still quite useful), today the range of models accommodated by DR is too limited, the 'interactive' user interface of DR is outdated, and improved strategies for some computational techniques used have become available in the meantime.


There is limited literature regarding effect of various clinical parameters on TIMI flow in ACS patients who underwent PCI. Also, it is not well known whether oxidative stress which is produced at local site can influence TIMI flow. Our study was done to evaluate role of various clinical parameters and oxidative stress markers on TIMI flow. The TIMI flow showed significant (r= -0.27, p 0.05) with TIMI flow. Pre PCI scores of TIMI flow are much dependent on clinical characteristics rather than antioxidants and free radical marker.


In this simple experiment for an undergraduate laboratory a laser beam is passed through the mixing zone of two liquids with different refractive indices. The spatial variation of the refractive index, at different times during the mixing, can be determined from the observed deflection of the beam.


Acknowledgements. Introduction. Part 1: Biography, biology and career. Part II: Professional socialisation and patriachal culture. Part III: Challenging patriarchy: No Man's Land?


Since at least the 1960s gun ban advocates have claimed that most murders are committed by ordinary law abiding adults just because they happen to have access to a gun at a time when they get angry. This is utterly false. Homicide studies invariably show perpetrators to be extreme aberrants with life histories of violence, crime, psychopathology and/or substance abuse. If such people could be disarmed there would be no gun crime (though they would kill with other weapons).Such people have no right to arms: (a) because at common law they were not part of "the people" of whom the Second Amendment speaks; at common law felons were "civilly dead," having no right to property of any kind, much less guns; and (b) because throughout history societies recognizing a right to arms have confined that right to "the virtuous citizenry," a category that excludes criminals, juveniles and the insane.


Center for Agrotechnology Innovation, Gadjah Mada University (PIAT), one of the place for development and breeding ground of spotted deer in Yogyakarta, Indonesia. The study of blood profiles was intended to allow veterinarian to understand the normal profile of the spotted deer. Fifteen healthy spotted deer belonging to PIAT were used as experimental animals. The deer were drawn its blood through the jugular vein without the use of anaesthesia. Blood was then accommodated in an EDTA tube, centrifuged at 2500 RPM and analyzed using a Mindray BC-2800 haematology analyzer machine. Based on the results of the study of the blood it were known that  Haemoglobine (Hb) was: 11.5 ± 1.703 g/dl, Red blood cells (RBC) was: 9.3 ± 3.580 10 6 /ml, Packed cell volume (PCV) was: 30.8 ± 6.035 %, Mean corpuscular Volume (MCV) was: 36.8 ± 11.102 fl, Mean corpuscular haemoglobine (MCH) was: 15.0 ± 7.313 pg, Mean corpuscular haemoglobine concentration (MCHC) was: 40.0 ± 14.657 g/dl, White blood cells (WBC) was: 6.4 ± 3.096 10 3 /ml , Neutrophils was: 43.4 ± 21.646, % Basophils was: 0.2 ± 0.168 %, eosinophils was: 0.4 ± 0.447 %, lymphocytes was: 53.4 ± 21.546 % and monocytes was: 2.6 ± 2.394 %. From all of the datas it indicated that blood profiles of PIAT's spotted deers are different from similar spotted deer blood profiles in India.


Antiphospholipid antibodies (aPL) are a group of autoantibodies, mainly of the IgG and IgM class, directed predominantly against negatively charged phospholipids.1-4 Several recent studies have found that patients with these antibodies are prone to repeated episodes of venous and arterial thrombosis, recurrent fetal loss, and thrombocytopenia."'5 In addition, there have been reports of the possible association of aPL with heart valve lesions,6 haemolytic anaemia5'7 and neurological events such as cerebrovascular accidents8 and chorea.9 Patients with these clinical and serological features have been defined as having the 'antiphospholipid syndrome'. 0 However, in the clinical practice, two main questions remain to be elucidated for physicians. Firstly, which laboratory test is the best to detect aPL antibodies? Secondly, in which circumstances should these antibodies be sought? With regard to the best technique, aPL may be detected by serological tests for syphilis (STS),I1 the lupus anticoagulant (LA) tests,'2-'4 and the tests based on solid phase radioimmunoassay'5 or enzyme linked immunosorbent assay (ELISA)1'617 using negatively charged phospholipids such as cardiolipin as antigen. STS rely on agglutination (e.g. VDRL) or complement fixation (e.g. Wasserman) assays to detect 'reagin,'l" the aPL present in syphilis. The LA tests depend on the ability ofsome groups ofaPL to prolong phospholipid-dependent in vitro clotting tests, such as the activated partial thromboplastin time, the Russell viper venom clotting time and the prothrombin time determined using dilute thromboplastin.12-'4 Solid phase techniques have proved to be the most sensitive and reliable methods of detecting and measuring aPL.'5-17 Nevertheless, in our opinion, both LA tests and solid phase assay (e.g. ELISA) for anticardiolipin antibodies should be ordered, since in up to 20% of cases one may give a positive result but not the other.'8'9 The detection of other negatively charged phospholipids, such as phosphatidylserine, phosphatidylinositol, and phosphatidic acid, gives little additional information. In which clinical conditions should the determination of these antibodies be considered? Due to the wide spectrum ofclinical manifestations related to these antibodies, this question remains unanswered. Nevertheless, the main indications may be as follows:


Objective:To investigate the expressions and significance of bcl 2 and p53 proteins in prostate carcinoma.Methods:The expressions of bcl 2 and p53 were studied by means of immunohistochemical ABC technique in tissues of 36 cases of prostate carcinoma (Pca),20 cases benign prostatic hyperplasia (BPH) and 11cases of normal prostate (NP).Results:①It showed that bcl 2 expression in Pca and BPH was significantly higher than that in NP (P0 05,P0 05),and there was no significant diference between Pca and BPH.p53 expression in Pca was significantly higher than that in BPH and NP.(P0 05,P0 05).and there was no significant difference between BPH and NP.②10 cases,including 4 cases of grade Ⅰ,Ⅱtumors and 6 cases of grade Ⅲ,Ⅳ tumors, revealed bcl 2 positive stain (P0.05).12cases,including 5 cases of grade Ⅰ,Ⅱtumors and 7 cases of grade Ⅲ,Ⅳ tumors, revealed p53 positive stain (P0 05).It showed that exprexxion levels of bcl 2 and p53 protein in Pca tissues increased with the progression of patholoical grade.③The expression of p53 was frequently detected in ≤5 year survival group than it was in 5 year survival group (P0.05) that of bcl 2 expression was no relatedsurvival period (P0.05).Conclusion:bcl 2 and p53 protein over expression might be related to the carcinogenesis?progression patholoical grade and prognosis of prostate carcinoma.


The problem being adressed by IPRO 325C is inefficient usage of energy in the developing world. The team trying to provide solutions for people who don't have access to facilities such as power plants and gas stoves. For example, there are millions of people worldwide who still use dangerous and unhealthy open fires to cook their food. This contributes to a plethora of problems, including deforestation, health issues like bronchitis and asthma, and ozone layer damage. In short, the team is trying to produce a sustainable Energy solution for the world's rural poor for less than $ 5.


The invention relates to a device for supplying a treatment plant with the process air, comprising an air duct system for supplying fresh air to the treatment installation and removal of laden with particles exhaust air from the treatment system, a separation system for the separation of the particles and in the outgoing air control means, wherein the separation system comprises at least one filter module having at least one replaceable filter element for receiving the separated particles. According to the invention it is provided that the filter element is an RFID transponder, and the device comprising a RFID reader, wherein the RFID reader is arranged so that, for a removal and / or installation of a filter element, an RFID reading operation and can be initiated communicable.


Bus bar assembly (100) comprising: a plurality of busbars (160, 162, 164) including a first DC busbar (160), a second DC busbar (164), and an AC busbar (162) therebetween in a vertically layered configuration; a plurality of power semiconductor devices (102, 106, 202, 204) that are in contact with and mounted between the plurality of bus bars (160, 162, 164); wherein at least one of the busbars (160, 162, 164) comprises a built-in cooling system, wherein the built-in cooling system comprises one or more channels (314) configured to receive a coolant flowing therethrough, characterized in that the one or more channels (314) are formed by loving a seal plate (310) to a body (312) having a plurality of grooves formed in a surface.


C Callou. 2003. De la Garenne au Clapier: Etude Archeozoologique du Lapin en Europe Occidentale. Memoires du Museum National d'Histoire Naturelle 448 189:1-358 (in French). ISBN 2-85653-545-3, price (hardbound), €75.00 (including a CD-ROM).

The European rabbit ( Oryctolagus cuniculus ) is distributed over all continents except Antarctica, as the result of introductions of wild or domesticated animals. However, at the beginning of the Holocene, this species was restricted to the Iberian Peninsula. Callou's book, based on her Ph.D. dissertation, provides useful insights for understanding the natural migration of wild animals in western Europe and the recent global success of the rabbit. According to the title, the objective of this book was to reconstruct the main steps of this spreading over western Europe, by using a wide range of data from paleontology, archeozoology, genetics, ethnology, and anatomy.

The 1st chapter is quite brief and discusses subspecific taxonomy by using morphological, parasitological, and genetic evidence. Two subspecies are reported according to weight and pelage characteristics: O. cuniculus cuniculus (Linnaeus, 1758) and O. c. algirus Loche, 1848. Mitochondrial DNA also split the rabbit populations into 2 groups (A and B), but these are not consistent with morphological subspecies.

Population structure, habitat use, and natural factors likely to limit the spread of the species are then considered in a short bibliographic synthesis. The last section of this chapter concerns taphonomy and points out the difficulty in studying archaeological remains because they can be either intrusive, exogenous, or altered …


Substrate surface preparation before chemical vapor deposition is an important step for the adhesion. This study describes the influence of the temperature and the RF bias during in-situ argon plasma treatment on TA6V substrates just before Plasma Enhanced Chemical Vapor Deposition (PECVD) of alumina. Substrates were treated under oxygen plasma without introducing aluminum precursor during 90 seconds under process PECVD conditions that were later used for coatings development. The surface of the samples is analyzed by Electron induced X-ray Emission Spectroscopy to study the physicochemical environment around the aluminum atoms. Atomic Force Microscopy (AFM) allowed to show the treatment impact on the surface morphology of the substrates. Coatings were characterized by the multicracking 4-point bending test. The results pointed out that the polarization value has a minor effect, whereas the temperature has a major influence. Introduction A well-controlled deposition process allows to obtain a film with properties corresponding to a specific application. The main problem consists in the compatibility between the film and the substrate and the optimization of the surface preparation. Mechanical behavior, particulary film adhesion to substrate is very dependent on substrate surface preparation. This study is concerned with the mechanical behavior of alumina films obtained by microwave PECVD on a TA6V alloy substrate. Samples were characterized by a multicracking 4-point bending test for different surface preparation conditions. Physicochemical and morphological analyses of the substrate surface just before the deposition step were conducted by EXES (Electron induced X-ray Emission Spectroscopy) and AFM (Atomic Force Microscopy). In EXES, a core hole is created in an atom of atomic number Z by collision with an incident electron. This core hole initial state can relax by radiative transition. The emitted spectral density describes the convolution of the distributions of the initial and final states, multiplied by the transition probability. If the final state involves the valence band, information on the valence states and the bonding characteristics can be obtained. The EXES is a nondestructive method. It is depth selective because the electrons gradually lose their energy in the matter. By choosing the energy of the electrons suitably, it is possible to probe the bulk or the surface of a material or, in the case of a thin film on a substrate, a buried interface [1]. The multicracking test allows studying the cracks network which appears perpendicular to the load direction during the 4-point bending test. The number and the position of the cracks are noted by means of an optical microscope for increasing strains and a statistical treatment is then carried out [2]. The crack density analysis characterizes the brittleness of film and its homogeneity. Moreover, informations about the film adhesion are also obtained. The influence of two surface preparation parameters was studied: the RF bias applied to the substrate and the substrate temperature during the argon microwave plasma of cleaning, which is the first stage of the alumina coating process. Key Engineering Materials Online: 2004-05-15 ISSN: 1662-9795, Vols. 264-268, pp 545-548 doi:10.4028/www.scientific.net/KEM.264-268.545 © 2004 Trans Tech Publications Ltd, Switzerland All rights reserved. No part of contents of this paper may be reproduced or transmitted in any form or by any means without the written permission of Trans Tech Publications Ltd, www.scientific.net. (Semanticscholar.org-13/03/20,18:13:35) Experimental Conditions


DECEMBER 2008– PAGE 1 Inside BRFSS Influenza Vaccine Rates .................................. 1 Flu Vaccination Rates Change ..................................... 2 Influenza Season Review.............................................. 2 Suicide Rate Hits High .................................................. 3 Immunization Rates for Kansas Children Increase .. 4 MCH Trends Reported................................................... 5 BRFSS & Diabetes Risk Health Professional.............. 6 Shortage Areas Report ................................................. 7 Demographic Profile of Uninsured Working Adults... 7 Trends in Breast Cancer ............................................... 8 2007 Kansas Vital Statistics Summary Released .... 10 Influenza Vaccination Rates Among Kansas Children — BRFSS Data Every year, an average of 20,000 children aged 0-4 years are hospitalized because of laboratory-confirmed influenza [1]. Among children aged 0-4 years with high-risk medical conditions, the rate of hospitalization because of laboratory-confirmed influenza is 250-500 cases/100,000 children [2]. Although influenza-associated deaths are uncommon among children aged 0-4 years, during the 2007-08 influenza season, 86 children died from influenza-related complications [2]. Although annual influenza vaccination can reduce the chances of experiencing severe complications or dying from influenza infection, national vaccination rates remain low among all population groups. Although not intended to be nationally representative, vaccination coverage rates among children aged 6-23 months and 24-59 months in eight Immunization Information Sentinel (IIS) sites during the 2007-08 influenza season were 40.8 percent and 22.2 percent, respectively [3]. In 2006, the Advisory Committee on Immunization Practices (ACIP) recommended that children aged 6-59 months be vaccinated annually against influenza because rates of hospitalization are highest among that age group. In addition, children of any age with asthma or other chronic medical conditions were also included in the recommendations [4]. In 2008, influenza vaccination recommendations were revised to include all children aged 6 months -18 years [2]. Interventions targeted at improving vaccination coverage include physician counseling. Studies have reported that physician counseling improves targeted vaccination rates among groups at high risk [5]. This study was conducted to determine influenza vaccination coverage among Kansas children during 2007, before the universal influenza vaccination recommendations were made, and to examine the association between physician counseling and influenza vaccination rates among these groups by using the Kansas Behavioral Risk Factor Surveillance System (BRFSS). Methods BRFSS is a state-based survey that collects information on health-risk behaviors, health conditions, preventive health practices and healthcare access. The 2007 BRFSS survey design was conducted by using disproportionate stratified sampling of nonmobile telephone numbers [6]. Data were weighted to account for the complex sample design and differential response rates among age and sex groups. In Questionnaire Version 2 of the 2007 BRFSS survey, a child under age 18 was randomly selected within the household. The respondent was asked if this child had been vaccinated against influenza, if influenza vaccination had been recommended by a physician and if the child had physician-diagnosed asthma. SAS 9.1 software (SAS Institute, Inc., Cary, North Carolina) was used to analyze the data generated from parent respondents to this version of the questionnaire, using data weighting to allow for generalization of results to the whole population and analytic procedures to account for the complex sampling design. Researchers examined the association between influenza vaccination rates and other factors (e.g., presence of asthma or another high-risk condition) and other demographic factors (e.g., parent's education level and residence [urban: population greater than or equal to 40 persons/sq. mile versus rural: population less than 40 persons/sq. mile]). Also assessed was whether physician counseling for influenza vaccination was associated with vaccine uptake.


This study was based on the experiences of seven proteges and seven mentors in a school-based mentoring program for at-risk students. The purpose of the study was to gain insights into the experience of school-based mentoring relationships from the perspectives of proteges and mentors, the relevance of a school-based mentoring program and the program design. The data were collected through semi-structured ethnographic interviews which included the construction of a narrative account and the recalling of critical incidents (Flanagan, 1954). Interviews were audio taped and transcribed verbatim. Data analysis was based on the empirical phenomenological psychological method (Karlsson, 1993). The results obtained from the data analysis were presented in terms of common themes, reflecting the proteges' and mentors' experience of their mentoring relationships. The findings of this study led to the general conclusions that (1) schoolbased mentoring relationships can facilitate the learning of new knowledge for both proteges and mentors (2) school-based mentoring relationships can be positive experiences for both proteges and mentors and (3) school-based mentoring relationships can be mutually beneficial providing proteges with a significant adult in their lives and mentors with the opportunities to share experiences and have a positive impact on at-risk youth. In addition to these three general conclusions, the findings of this study identify several important characteristics of positive mentoring relationships from the perspectives of both mentors and proteges.


To determine the frequency of sonographically evident upper extremity venous thrombosis in symptomatic cancer patients with and without central venous catheters.


Abstract A formulation of influence coefficient matrices is derived from the equations of motion for unsymmetrical rotors by using a complex co-ordinate representation and the finite element method. Due to the unequal properties in the two principal directions, the present formulation results in two sets of modified influence coefficients. The formulation indicates that two trial masses place in different directions are required in the two trial operations for each balancing plane. Also, from the analysis, the modified influence coefficients are found to be correlated to forward precession and imbalanced forces when the asymmetry of the bearings is considered. Therefore one requires forward precessions instead of measured displacements to calculate the influence coefficients and imbalance distribution. Several examples are presented to verify the validity of the present work.


Abstract Conclusion: Partial laryngopharyngectomy (PLP) provides acceptable oncologic results and laryngeal preservation rate in selected patients with squamous cell carcinoma of the hypopharynx. Even when local recurrence develops, the chance of successful salvage is still high. Objectives: To evaluate the oncologic results and laryngeal preservation rate in patients with squamous cell carcinoma of the hypopharynx who underwent PLP. Methods: The results of 39 patients who underwent PLP were compared with those of 91 patients who underwent total laryngectomy (TL). Results: The distribution of the primary T stages were 23 (59%) pT2, 9 (23%) pT3, and 7 (18%) pT4; the pathologic stages were 8 patients (21%) stage II, 9 (23%) stage III, and 22 (56%) stage IV. All of the patients also had ipsilateral or bilateral neck dissections. Eighteen patients (46%) received postoperative adjuvant therapy. After a median follow-up of 39 months, 17 patients (44%) had recurrence, including 12 local, 2 regional, and 3 distant lesions. The 5-year overall and disease-specific survival were 44% and 56%, respectively; functional preservation was 62%. The recurrence rate was similar in patients treated with PLP and TL (44% vs 36%, p = 0.431); the local recurrence rate was higher after PLP than after TL (31% vs 8%, p = 0.001). The salvage surgery was successful in four of the six patients (67%). After salvage treatment, the 5-year overall survival (44% vs 47%) and disease-specific survival (56% vs 62%) were similar in the two groups.


FIELD: cosmetology. SUBSTANCE: cosmetic spraying or evaporable composition in the form of aerosol contains in cosmetically acceptable aqueous or aqueous-alcoholic medium at least one fixing polymer and/or conditioner and at least one alkylacrylate copolymer with alkylmetacrylate and acryl acid. The proposed copolymer is used as an agent improving quality of evaporation or spraying of cosmetic compositions. The claimed composition does not froth and has higher diffusive spraying. EFFECT: improved quality. 18 cl, 3 tbl, 6 ex


Adoptive immunotherapy with ex vivo-expanded antigen-specific cytotoxic T lymphocytes (CTLs) has been shown to clear viral infections and eliminate tumors in murine models. Clinical trials have also reported promising data for the use of adoptive immunotherapy to treat cytomegalovirus (CMV) and Epstein-Barr viral (EBV) infections in bone marrow transplant recipients. For these indications, the need for ex vivo-expanded CTLs is often short lived, until the immune system is reconstituted by the donor transplant. In chronic disease settings, increased longevity of adoptively transferred CTLs and generation of memory will be necessary. The additional administration of helper functions normally supplied by antigen-specific T helper (Th) cells will probably be essential for long-term survival of adoptively transferred CTLs. Toward this goal of supplying helper functions, we transduced human CTLs with chimeric GM-CSFR/IL-2R receptors that deliver an IL-2 signal on binding GM-CSF. Clones expressing the chimeric receptors proliferated in response to GM-CSF. Stimulation with antigen induced GM-CSF production and resulted in an autocrine growth loop such that the CTL clones proliferated in the absence of exogenous cytokines. This type of genetic modification has potential for increasing the circulating half-life and, by extension, the efficacy of ex vivo-expanded CTLs.


The effects of changes in lifestyle, as well as, in the population's food consumption represent a strong indicator of quality of life, where they directly and indirectly affect individuals in the most diverse ways. In the dairy sector, a trend that has always shown innovations is the production of functional yoghurts and fermented milks. This is because, in addition to these products having great acceptance by the general public and presenting excellent nutritional value, they are potential vehicles for the consumption of probiotics. Therefore, the objective of this work was to elaborate different concentrations of fiber-rich yogurt, mango flavor, from water-soluble soy extract, supplemented with sesame and inulin, and to evaluate the purchase intention by possible consumers. Thus, the yogurt was made from water-soluble soy extract, supplemented with sesame flour, administered for enrichment in the beverage's fibers, obeying concentrations of 0.0% (control), 20%, 25% and 30%. The formulations were offered and analyzed by 30 untrained tasters, with the data obtained by 2 affective tests, a 9-point hedonic scale, in which the attributes such as texture, aroma, flavor and global acceptance of the sample were evaluated, ranging from very much to the taste. I really disliked it; and 3-point hedonic scale regarding purchase intent. The standard formulation (control), followed by the formulation supplemented with 1.5% inulin and 20% sesame flour, were well accepted, the latter being analyzed by physical-chemical methods for its characterization. As for the purchase intention, yogurt supplemented with 20% sesame flour and 1.5% inulin, was well evaluated by the 18 to 24 year old age groups, as well as by the 46 to 54 age group, this public, heterogeneous. In the physical-chemical analyzes, the contents of ash (1.08%), proteins (5.59%), and total fibers (4.9g), were high, demonstrating that it is a source of fiber, as this last one. The moisture content (39.00%) and total fat (2.02%), were low. In this way, the present study fulfilled the proposed objectives, providing the general population with another functional drink option, both rich in fiber and probiotic. As well, by encouraging the use of the pink mango pulp, widely produced in the region, to contribute even more to its economic growth and development.


Abstract Developing a search strategy for a systematic review is a time-consuming process in which small errors around the formatting and compilation of terms can have large consequences. Microsoft Excel was identified as a potentially useful software to streamline the process and reduce manual errors. Ultimately a spreadsheet was created that largely automates the process of creating a single-line search string with correctly formatted terms, Boolean operators and parentheses.


eck thoroughly the urethra eatment. We have custom-unds available were of the :sary for each case. ~. 26 and 28F, could be in-lbs sufficiently far apart to .d give us one small con-. ' .dily available· and which important test. months and find it very • the urologist's armamen-. urethral strictures which : technique advocated by t of the cases. Several months ago the urology service at this hospital began to investigate a new anesthetic drug. This new drug called Xylocaine (diethylamino-2:6 diethylacetanalide) was first described by Lofgren and Lundquist of Sweden and its pharmacologica.l properties were studied by Goldberg, who compared it with procaine and tet:rocaine as to toxicity; action on blood pressure, anesthetic qualities , including its use as a topical anesthetic, and local irritant action. He concluded that Xylocaine showed high degrees of anesthetic potency both for surface and infiltration purposes and that it displayed a con;tbination of pharmacological properties which strongly urged its us~ for clinical purposes. · ,Of the many qualities desirable in an anesthetic, including low toxicity and effective interruption of painful st:iilluli, rapidity of action is especially important to the urologist who would prefer to be able to do cystoscopy without having to wait for long periods of time, while an anesthetic agent is taking effect. We believe that Xylocaine has these favorable attributes.. We have used Xylocaine in a 2 per cent solution as a topical anesthetic for transurethral procedures varying from mere passage of sounds to cystoscopy with extensive fulguration o{bladder papillomas. Our results have been highly satisfactory and we have noted no untoward reactions. Approximately 10 cc are used for each cystoscopy except in .females in whom Xylcicaine soaked ap-plicator sticks have been successfully used. It is extremely difficult to evaluate an anesthetic agent in cystoscopy wherein so much depends upon subjective differences as well as upon the technique and .skill of the operator. In our series of 250 cases, we have made a special point of including those patients who had had previous cystoscopy either at this hospital or elsewhere when Xylocaine was not used.· Almost without exception, these. patients have expressed a definite preference for the procedure in which Xylocaine was used. In many instances the same operator had occasion to examine these patients with and without the benefit of Xylocaine and the results were rather dec:lsiv~ in favor of this agent. Several cases in our series are …


The domestic slave trade has always bulked large in discussions of the character of American ante-bellum slavery. Assumptions and arguments about the nature of master-slave relations, about family separations, and about the slave family have necessarily had much to do with slave sales and with the extent and character of the domestic traffic in slaves. All this has, however, been despite the fact that no satisfactory quantitative estimate of the trade has been available. Indeed, the standard work on the American domestic slave trade, Frederic Bancroft's Slave Trading in the Old South (1931), has recently been challenged in the studies of Calderhead (1972) and of Fogel and Engerman (1974), and those studies have in turn been questioned by, for example, Gutman and Sutch in Reckoning with Slavery (1976). The present study will seek to offer a more satisfactory estimate of the trade than has so far been available, and will argue that the trade accounted for the substantial majority (somewhere between 56 and 69 per cent) of the more than one million net inter-regional slave movements which took place in the South over the period 1820 to 1860.


For almost 30 years, at synchrotron facilities, it has been possible to perform small-angle x-ray scattering experiments whilst simultaneously measuring differential scanning calorimetry (DSC). However, a range of challenges exist to enable the collection of simultaneous small-angle neutron scattering (SANS) and DSC data associated not only with intrinsic flux limitations but also scattering geometry and thermal control. The development of a DSC (temperature range ca. −150 °C to 500 °C) suitable for SANS is detailed here and its successful use is illustrated with combined measurements on a binary blend of normal alkanes in which one component has been deuterium labelled.


The invention relates to a microcomputer automatically controlled spraying and temperature-lowering device for livestocks, which comprises a temperature inductor, a micro computer control automatic clock switch, an electromagnetic switch or immersion pump, a spray cap switch and a mist spray nozzle, the system can realize the automatic control for mist spray nozzle to spray water fog in the shape of reversed umbrella, thus providing domestic animals with the functions of analgesic, warm prevention and cooling down, so as to alleviate livestock heat irritated response.


In this issue of Occupational and Environmental Medicine, Yu et al present findings from a study of 199 miners with progressive massive fibrosis (PMF). Patients at high or intermediate probability of having pulmonary hypertension (PH, n=79) were defined, for the purposes of this study, as having PH on echocardiogram in combination with secondary signs of PH. Patients were characterised by CT, and adjusted regression analysis identified that both large and central opacities were predictive of PH, and the authors assert that the mechanical obstruction to the proximal pulmonary vasculature may be aetiologically important. These findings further support the view that echocardiographic features of even mild elevation of PA pressure are associated with a worse prognosis, with those defined as having an intermediate or high probability of PH having a survival of 73.3% compared with 96.6% for the nonPH group over a median followup of 32.8 months. There are some limitations to consider. It is likely that the true prevalence of PH is lower than quoted, given that echocardiography tends to overestimate its presence in patients with lung disease. Also, only a small number of patients underwent CT pulmonary angiography, and the influence of other potentially causative variables is also inherently difficult to estimate in such studies. Indeed, further multimodality investigation would have been very helpful in this context, as its merits in a similar scenario is described. Yu et al's assertion is not new. The authors cite early work noting a link between right ventricular hypertrophy and the presence of PMF in coalminers. Subsequent work has suggested that obliteration of the vascular bed may be an important causative mechanism for PH, assessed by right heart catherisation, in a group of coal workers. Further data from a group of Chinese coal workers with pneumoconiosis also identified increases in PA pressure that were related to the severity of disease. More recently, Xu et al have reported eight patients with PH; attributed to the combination of bronchial anthracofibrosis and fibrosing mediastinitis. Interestingly, patients had a combination of bronchial stenoses and elevated PA pressures, evidence of hypoxaemia and PA stenoses. It was postulated that PH may have developed as a consequence of fibrotic mediastinal lesions causing both bronchial and pulmonary arterial compression. Given that miners with PMF have a worse prognosis compared with those with no PMF, what is known about PMF treatment in this population? Unfortunately, evidence supporting active vascular interventions in PMF is uncommon. PA stenosis secondary to silicosis has been reported, as has successful percutaneous intervention with an improvement in functional capacity in a stonemason. The latter had evidence of disseminated nodularity and enlarged hilar and mediastinal lymph nodes. Right heart studies identified preintervention PH. Following PA balloon and stent interventions, the patient improved functionally and symptomatically, although no post intervention PA pressures were presented. Similarly, improvement in echocardiographic assessed right ventricular hypertrophy has been reported following pulmonary vascular stenting to treat pulmonary vascular stenosis secondary to fibrosing mediastinitis. Additionally, there are descriptions of successful operative intervention in patients with tuberculosis related fibrosing mediastinitis. Ahn et al have also recently reported percutaneous PA intervention for a stenosis secondary to anthracosis. The 51yearold granite stone worker underwent balloon inflation and stenting, which led to a significant clinical improvement and an associated reduction in estimated PA pressure. The findings reported by Yu et al will add to the understanding of PH attributed to PA luminal occlusion, or stenosis, from PMF. Further multimodality characterisation and study of patients with PMF, however, will be required in order to identify optimal treatment strategies, which may in the future more commonly include such vascular interventions.


This paper studies an effect-abstraction based relaxation

 for reasoning about linear numeric planning problems. The effect-abstraction

 decomposes non-constant linear numeric effects into actions with conditional

 effects over additive constant numeric effects. With little effort, on this

 compiled version, it is possible to use known subgoaling based relaxations

 and relative heuristics. The combination of these two steps leads to a novel

 relaxation based heuristic. Theoretically, the relaxation is proved tighter

 than previous interval based relaxation and leading to safe-pruning

 heuristics. Empirically, a heuristic developed on this relaxation leads to

 substantial improvements for a class of problems that are currently out of

 the reach of state-of-the-art numeric planners.


We have employed a composite rheology consisting of both linear and nonlinear creep mechanisms which are connected by a 'transition' stress. Background stress due to geodynamical processes is included. For models with a non-Newtonian upper-mantle overlying a Newtonian lower-mantle the temporal responses of the displacements can reproduce those of Newtonian models. The average effective viscosity profile under the ice-load at the end of deglaciation turns out to be the crucial factor governing mantle relaxation. This can explain why simple Newtonian rheology has been successful in fitting the uplift data over formerly glaciated regions.


After long-term accumulation, weathering and rainfall of metals and non-metals in tailings ponds, the chemical composition will change, and the surface heavy metals may gradually migrate to the bottom layer, thus showing a cumulative effect. At present, the distribution of cyanide and heavy metals in vertical space has not been reported. In this work, 12 sampling points were arranged for a cyanide tailings pond by the grid method in Jilin, China. The contents of cyanide and heavy metals were determined according to the standard method. The results show that the heavy metals in the tailings were mainly Cu, Pb, Zn and Mn (342.83 mg/kg, 571.09 mg/kg, 610.15 mg/kg and 796.63 mg/kg, respectively), and the concentration of heavy metals in the horizontal direction does not change significantly. It should be noted that the concentrations of zinc and manganese did not change much in the vertical direction. The concentration of copper and lead increased with the increase in depth. The concentration of cyanide at the sampling site far away from human activities was higher at 6.71 mg/kg, and the average concentration is 2.5 mg/kg. In addition, because the cyanide is unstable and affected by factors such as light and rainfall, the concentration change in the vertical direction fluctuates.


The purpose of this article is not to discuss fieldwork at large but rather to examine the position and role of the research method in one discipline, comparative education. For this purpose, first of all, the content of articles published by the Japan Comparative Education Society's journal over the past 35 years is analyzed. Based on this analysis, the implications, significance as well as apprehension surrounding doing fieldwork in comparative studies of educa tion are then discussed. There are 504 articles published from the first volume to the latest No. 39. The classification based on a full reading of all the articles indicates 86 (approximately 17.1%) are found to be based on the data and information collected and formed by the researchers themselves with the various techniques in their fields. While studies about Western advanced countries account for a majority in all articles, those utilizing various techniques in the field remain limited at 20. The rest of the fieldwork-based articles concern developing countries. However, an increasing number of fieldwork-based stud ies have been appearing in the JCES journal. Not only has the speed of this increase been accelerating, but also the quality of the fieldwork seems to have been improving gradually. Similarly, countries and areas to be the object of investigation have been diversifying. What is perhaps the most salient phenomenon is that studies centering on advanced Western countries are also coming to adopt fieldwork as their primary research method. These recent academic trends may indicate that studies in Comparative Education in Japan are finally coming into their own: what was long considered a 'peripheral' or 'consumer' position in academia is now being replaced with hope for making original and active contributions to research in the field.


We analyze the impact of the state on the incidence of poverty in the working-age population of 14 advanced capitalist democracies between 1970 and 1997 using an unbalanced panel design. We utilize poverty measures based on micro-level data from the Luxembourg Income Study in conjunction with pooled time series data from the Huber, Ragin and Stephens (1997) database. We argue that economic factors including de-industrialization and unemployment largely explain pre-tax, pre-transfer poverty rates of the working age population in advanced capitalist states. These rates, however, are theoretical as advanced democracies redistribute resources through taxes and transfers. We show that the extent of redistribution (measured as poverty reduction via taxes and transfers) is explained directly by welfare state generosity as well as constitutional structure (number of veto points) and the strength of the left, both in unions and in government.


Smoking increases the risk of peripheral artery disease (PAD), but the mechanisms are not well established. This study evaluated the association of local circumferential wall tension (CWT), markers of vascular remodeling and stiffness, and traditional risk factors with popliteal and carotid plaques among smokers and non-smokers. Two hundred fifty-two subjects (126 smokers and 126 non-smokers) underwent clinical, laboratory, and popliteal and carotid ultrasound analysis. Popliteal and carotid CWT measures were calculated in supine and orthostatic positions, and supine position, respectively. Popliteal plaques were more common in smokers than non-smokers (39% vs. 19%; p<0.001). Among smokers, popliteal plaques were not related to differences in traditional vascular risk factors. In propensity score-adjusted models, popliteal CWT measures were associated with local plaques in smokers, but not in non-smokers. Peak orthostatic CWT was the measure showing the most significant association with popliteal plaques (Beta±standard error=0.91±0.28; p=0.001). Local CWT measures also showed a stronger association with popliteal intima-media thickness among smokers as compared with non-smokers. By contrast, nonsmokers with popliteal plaques were more likely to have older age, hypertension, diabetes and dyslipidemia, and lower arterial compliance among non-smokers. Lastly, carotid plaques were not independently related to local CWT among smokers. These findings indicate that risk factors for PAD may differ between smokers and non-smokers and further suggest that atherosclerosis in lower limb arteries is directly related to local hemodynamic forces among smokers.


Objective To study the changes of genomic density polymorphism and quantitative expression of complement receptor type 1( CR1) on erythrocytes and erythrocyte innate immune adhesive function( EIIAF) in psoriatic patients in order to explore its possible role in the pathogeneses of psoriasis. Methods Rapid detection was used to detect EIIAF. The expression levels of CR1 on erythrocytes were detected by enzyme-linked immunoassay. The genomic density polymorphism of CR1 on erythrocytes was determined with polymerase chain reaction( PCR) and Hind III restriction enzyme digestion. Results The activity of EIIAF was significantly higher in patients than in normal controls( P 0. 05). The expression levels of CR1 on erythrocytes were also higher in the patients than in normal controls( P 0. 01). The levels of CR1 were positively correlated with EIIAF. Spot mutation rates of low- expressed CR1 locus on erythrocyte density gene were no significantly differences( 17. 31% vs 10. 71%,P 0. 05) between the patients and the controls. The distribution of polymorphism of erythrocyte CR1 density gene was not significantly different( P 0. 05) between the patients( HH: 73. 08%,HL: 19. 23%,LL: 7. 69%) and healthy individuals( HH: 85. 71%,HL: 7.14%,LL: 7. 14%). Conclusion Increased the expression levels of CR1 on erythrocytes and EIIAF in psoriasis were not due to the changes in polymorphism of CR1 on erythrocyte gene. Higher CR1 and EIIAF may be involved in the pathogenesis of the psoriasis.


F.A.I.K. performed iodide efflux assays, and H.P. performed immunoprecipitation and Western blotting experiments. A.R. conducted I sc measurements. K.A. performed immunofluorescence microscopy stud- ies. C.A.D., S.S., and D.C.S. did the clinical studies. J.C.K. assisted in site-directed mutagenesis. All authors discussed the results and commented on the manuscript.


The rise in global average surface temperature has promoted the advancement of spring vegetation phenology. However, the response of spring vegetation phenology to different temperature parameters varies. The Mongolian Plateau, one of the largest grasslands in the world, has green-up dates (GUDs) with unclear sensitivity to different temperature parameters. To address this issue, we investigated the responses of GUDs to different temperature parameters in the Mongolian Plateau grasslands. The results show that GUDs responded significantly differently to changes in near-surface temperature (TMP), near-surface temperature maximum (TMX), near-surface temperature minimum (TMN), and diurnal temperature range (DTR). GUDs advanced as TMP, TMX, and TMN increased, with TMN having a more significant effect, whereas increases in DTR inhibited the advancement of GUDs. GUDs were more sensitive to TMX and TMN than to TMP. The sensitivity of GUDs to DTR showed an increasing trend from 1982 to 2015 and showed this parameter's great importance to GUDs. Our results also show that the spatial and temporal distributions of temperature sensitivity are only related to temperature conditions in climatic zones instead of whether they are arid.


We read with interest the recent paper by Boshuizen et al. (1) exploring the associations between mortality risk and current versus past values of systolic blood pressure (SBP) and serum cholesterol. We applaud their recognition that risk in a particular period may depend on both current and past exposure levels, and that these exposures may contribute differentially to current risk. However, we would like to highlight an assumption made under the two-step approach used by Boshuizen et al. to adjust for measurement error, which appears to have been violated in at least one of the analyses reported. In their paper, Boshuizen et al. use the two-step approach of Tsiatis et al. (2), which is essentially a form of regression calibration and as such makes the usual assumption that measurement error is nondifferential. The approach involves fitting a linear mixed model to longitudinal error-prone measurements of the exposures of interest—SBP and cholesterol. The mixed model is used to obtain empirical Bayes estimates of the true exposure levels 25 years previously and at the current age. In the second stage, the authors use these empirical Bayes values to fit a number of different Cox regression models, either using exposure at a single time point (hence not adjusted for levels at other time points) (table 4) or entering exposure at both time points simultaneously (tables 5 and 6). When fitting a model containing the true exposure level at a single point in time, Boshuizen et al. aim to estimate the unadjusted association between that true exposure level and disease. It is clear that because of confounding, these unadjusted associations may not represent causal associations. 502 Letters to the Editor


This article is written based on unique considerations in theworld of education and economic strategies in Islamic educational institutions. This research proposes a strategic framework that can help evaluate the relationship and linkages between economic strategies and Islamic education institutions. The evaluation is expected to be a material consideration in the management of economic strategies, so that the performance of Islamic education institutions can be improved. Institutional performance is evaluated using criteria that include productivity, cost reduction, innovation, reactivity, responsiveness, and collaboration. To get a complete picture in this article, a qualitative approach with the study of literature is used. The results of the study show that evaluating the relationship of economic strategy management in Islamic education institutions uses a framework. management functions include; planning, organizing, directing and controlling. Therefore, management is defined as the process of planning, organizing, leading, and controlling the efforts of the organization with all its aspects so that organizational goals are achieved effectively and efficiently.


A method for applying the topographic components (TC) model to discrimination and classification of multichannel evoked potentials (MEPs) is proposed, and a study designed to demonstrate and test this method is presented. The TC model is used to compare the MEPs of 'normal' and 'abnormal' test subjects to those of a normal reference group, as might be done clinically to screen patients for pathology. The spatial/temporal components identified for the reference group are demonstrated to fit the MEPs of the normal test subjects (not part of the group to which the model was originally fit), but not those of the abnormal test subjects. It is concluded that the TC model can indeed be a useful tool in MEP classification, e.g. in clinical diagnosis, and that further study is warranted along these lines.<<ETX>>


Addition of nitric oxide (NO) donors to NB69 neuroblastoma cells produced a cGMP‐independent decrease in cell proliferation, without affecting cell viability or apoptosis. The potency of short half‐life NO donors was higher when cell proliferation was stimulated by epidermal growth factor (EGF), as compared with cultures exposed to fetal calf serum (FCS). Immunoprecipitation and western blot analysis of the EGF receptor (EGFR) revealed a significant reduction of its EGF‐induced tyrosine phosphorylation in cells treated with the NO donor 2‐(N,N‐diethylamino)‐diazenolate‐2‐oxide (DEA‐NO). When total cell lysates were subjected to western blotting, we observed that DEA‐NO also reduced tyrosine phosphorylation in EGF‐activated phosphoproteins, but not in those proteins whose tyrosine phosphorylation was evident in the absence of EGF. The effect of NO on EGFR transphosphorylation was concentration‐dependent and transient, with a total recovery observed between 1.5 and 3 h after addition of DEA‐NO to the cells. When cells were incubated for 15 min with DEA‐NO and then washed, the EGFR transphosphorylation returned to control levels immediately, indicating that the interaction of NO with the receptor molecule was fully reversible. NB69 cells expressed both the neuronal and the inducible isoforms of NO synthase (NOS) when cultured in the presence of FCS; under this condition, the NOS inhibitor, Nω‐nitro‐l‐arginine methyl ester, produced a small but significant increase in cell proliferation. The results suggest that NO is an endogenous antimitotic agent and that its interaction with EGFR contributes to cytostasis in NB69 cells.


The application of information communication technologies (ICT) becomes more and more relevant at university studies; thus a teacher needs ICT competence. Research literature analyses what is necessary for a teacher to use ICT in educational activity; however, coherences of teacher's ICT competence and the study programmes have not been disclosed. The article addresses the following research question: how does a study programme create premises for the manifestation of teacher's ICT competence? This problem is solved in four parts of the article. In the first part the ICT competence of a university teacher is defined; the second part reveals the coherences of teacher's ICT competences and ICT implementation levels; the third part presents the research methodology. The fourth part reveals the coherences of teacher's ICT competence and the study programme. The methods of research literature analysis and document analysis were used in the article. The data were processed by the method of qualitative descriptive content analysis.


Utsuro et al., 2000) proposed statistical method for learning dependency preference of Japanese subordinate clauses, in which scope embedding preference of subordinate clauses is exploited as a useful information source for disambiguating dependencies between subordinate clauses. Following (Utsuro et al., 2000), this paper presents detailed results of evaluating the proposed method by comparing it with several closely related existing techniques and shows that the proposed method outperforms those existing techniques.


for example, is antithetical to political legitimacy, be it republican or authoritarian. Macbeth's tortured but sometimes emboldening connections to the supernatural sow confusion where there ought to be clarity about the material conditions of political order and hierarchy. Magis Prospero's heavy-handed governance of the island is likewise noted for the absent political work of sustaining actions in concert. There is a lesson for contemporary political magicians: "if people are obedient because of magic that's a failure of authority." So "voodoo economists and political wizards"—including the magic of charismatic leaders—do harm. They pursue shortcuts to legitimacy, says Frazer, and undermine the very relationships on which legitimate authority ought to rest. And yet, Frazer notes a tension: the spontaneity, the magic of movement politics, is a resource she wishes to acknowledge as a force that has done good, even if there is "nothing magic" about "human, social, normal, power" that makes up everyday political rule and its contestation (pp. 175–77, 187–93). This admirable survey of political ways and our failure to achieve a better politics through Shakespeare will animate further discussions, and Frazer distributes many fine turns of phrase throughout. She takes a risk, however, in covering somuch at this level of abstraction. Room for contestation is not large when it must compete for space with broad plotline summaries and bottom-up explanations of insights from fellow political theorists. Her sheep graze on the commons' grass, but she does not lead her goats into the weeds. We are rarely immersed, as in many works of interpretation, in sustained exchanges between characters. Historical points of connection are passed over quickly. She may leave some readers wondering if the delineation of a better politics did not sometimes displace the politics of scholarly debate. Her ultimate plea, however, is that we learn to live with the frustrations that politics brings, and on this score she puts Shakespeare to good use.


Reaction of a pyridine carbaldimine 2-tBuNCHC5H4N 1a with a molar equivalent of boron tribromide afforded a bicyclic 1,3,2-diazaborolium bromide 2a as an orange solid, whereas 1a and the corresponding 2-(2,6-Me2C6H3)N CHC5H4N 1b with two equivalents of boron trifluoride gave non-ionic yellow adducts 3a and 3b. The reduction of compounds 2a, 3a and 3b with an excess of sodium amalgam in a hexane slurry led to the formation of 1-X-2-R-1,2-dihydro[1,3,2]diazaborolo[1,5-a]pyridines 4 (X = Br; R = tBu), 5a (F; tBu) and 5b (F; 2,6-Me2C6H3) as yellow oils (4a, 5a) or a yellow wax (5b), respectively. Treatment of 4 with an excess of chlorotrimethylsilane caused a Br/Cl exchange to afford chloro derivative 6. The addition of a methyl group to the boron atom was effected by reaction of heterocycle 4 with methyllithium. The BCN derivative 8 resulted from treatment of 4 with silver cyanide. Reduction of 4 with lithium aluminium hydride gave the 1-hydro-derivative 9, whereas the BStBu compound was obtained from the reaction of 4 with KStBu. Compound 8 was subjected to an X-ray diffraction analysis.


We studied the effects of antihypertensive calcium channel blockers on CaV1.2, the predominantly expressed L‐type calcium channel in the largest human lymphatic vessel, the thoracic duct. Human lymphatic collecting vessels, both large and small, are highly‐sensitive in vitro to calcium channel blockers; exposure to these drugs inhibits endogenous lymphatic contractile activity and action potentials and diminishes noradrenaline‐induced phasic contractions. In vivo administration of calcium channel blocker nifedipine to healthy volunteers did not reduce lymphatic contractile activity despite all subjects achieving nifedipine plasma concentrations comparable with those observed to affect contractile function in vitro. These results indicate that calcium channel blocker‐related oedema is unlikely to be exacerbated by an off‐target effect of the drugs diminishing lymphatic pumping and fluid removal.


We show that Lemma 4.6 (and hence Proposition 4.9) in Jiménez López and Llibre (Adv Math 216: 677–710, 2007) has an essential gap. We amend this gap in the particular cases of the sphere, the plane, the projective plane and the projective plane minus one point, thus the main results in Jiménez López and Llibre (Adv Math 216: 677–710, 2007) remain correct. On the other hand, some counterexamples for the sphere minus two points and for the projective plane minus two points are given; as a consequence, Theorems 7.1 and 7.2 in Jiménez López and Llibre (Adv Math 216: 677–710, 2007) are incomplete.


The present invention relates to the use of radially capturing substances alone or in admixture in a topical preparation for the treatment of conditions with increased skin temperature, in particular for antipyretic treatment, wherein the composition has a radical protection factor of the preparation of at least 250 x 10


Switchable retaining ring pliers (10), the pivot (22), first and second jaws (18, 20), and pivotally fixed first and second (22) handle It is equipped with a (14, 16). Moving the handle (14, 16) on the inside, in order to establish the alternating operating state so that the jaws (18, 20) moves inside or outside, a pair of switching pins (56, 58) is, chin part (18, 20) and is slidably positioned for selective movement in the handle (14, 16). Also within jaws (18, 20) and the handle (14, 16), and a switching mechanism (12) for shifting the transfer pin (56, 58) at the same time. The switching mechanism (12) includes a pivot attached to both ends of (22), the handle reaction member housing assembly disposed in each of the outer surfaces of (14,16) (66,68). Switching plate structure (12) is rotatably mounted for movement to the left and right pivot (22), at least, the one one reaction member housing assembly (66, 68) the handle of the external surface of the (14, 46) It is arranged so as to slide between. The switching plate structure (12) is engageable with the inner and outer portions of the at least one reaction member housing assembly (66, 68), one end of the switching pin (56, 58).


The corrosion behavior of KT5916, 2Cr11Mo, and Co3W3 in high‐temperature and high‐pressure steam at 600°C, and 20 MPa were investigated. The kinetic weight gain curves of KT5916 and Co3W3 nearly followed a parabolic law. Oxide scale exfoliation was found in all steels. The oxide layer structural distribution of the three heat‐resistant steels was Fe3O4 layer and FeCr2O4 layer from the gas side to the substrate side, and the critical criterion for the formation of Fe2O3 oxide was 509.3°C. Under the influence of growth stress, the oxide film of the three heat‐resistant steels experienced a stable oxide layer, coarsening of oxide, pulverization of oxide, and exfoliation of oxide in high‐temperature and high‐pressure steam environments.


Photovoltaic and wind are renewable energy resources that widely used and grow rapidly in fulfilling electricity demand. Powers from both technologies depend on sunlight intensity and wind speed. For small scale power generation, DC voltage from both technologies is low and requires step-up converter to raise DC voltage ratio before converted into AC voltage. To optimize this system, step-up converter must have high ratio and efficiency to a distance of wide voltage input. This paper proposed an operation simulation and arrangement of DC-DC converter along with DC-AC from hybrid source PV-Wind which integrated to grid utilities without using storage device. High Gain Integrated Cascade Boost (HGICB) is DC-DC converter that has quadratic voltage ratio and used in this research. Then DC link connected to Voltage Source Inverter (VSI) which interconnected with utility grid and controlled by current control method. The total installed capacity of hybrid source is 4.4 kW. Wind turbine uses PMSG along with full bridge rectifier. To maximize and stabilize the generated power, MPPT fuzzy is used. Result from the simulation shows that converter capable to maintain maximum power whether from PV and wind turbine which canalized to utility grid in various irradiation condition, wind speed, and grid load alteration.


Aim To investigate antifungal effects of domestic butenafine and its topical treatment on experimental dermatophytosis in guinea pigs.Methods The in vitro fungistatic concentrations were determined by a serial dilution method using sabrouraud dextrose agar and the MIC was estimated as the lowest concentration that completely inhibited the growth of dermatophytes.1% betenafine cream was applied on the infected site of guinea pig dermatophytisis caused by Trichophyton mentagrophytes in comparison with those of clotrimazole,naftifine,and bifonazole.Results MICs of butenafine for dermatophytes were in the range of 0.002 5~0.32μg·ml -1 and its antidermatophyte activity was greater than those of the reference drugs,showing that butenafine exhibits potent fungistatic activity.Topical butenafine cream showed excellent efficacy against dermatophytosis and the effect was superior to that of clotrimazole,there was a significant difference between two groups(P0.05).The effect of butenafine was higher than those of naftine and bifonazole,but there was no significant difference among them(P0.05).The incidence of relapse rate of butenafine cream after topical treatment was lower than those of three reference drugs.Conclusion Butenafine cream has potential for treatment of superficial fungal infections in humans.


Gustav Bayerle died on 12 October 2016 in San Jose, California, at the age of 85. A refugee immigrant to the United States after the 1956 Hungarian revolution, Dr. Bayerle was a longtime faculty member and department chair at Indiana University. He was respected for his scholarship, his mentoring of students, and his leadership within the Turkish Studies Association of North America.


Background – The engineering field is concerned with needs for more engineers, diversity, and globally prepared engineers; however, theory suggests that these challenges indicate a more central challenge, that is, the misalignment between engineers' personal values and their vocations. At the same time, socially engaged engineering activities do not appear to experience the same challenges, which suggests their success at aligning personal values and vocations for a broader group of engineers. Purpose/Hypothesis – This research investigates the similarities and differences in personal values for engineers both involved and not involved in one of the most prominent engineering service organizations in the US, Engineers Without Borders (EWB-USA). Design/Method – Using a sequential mixed-method approach that combined variableoriented analysis of interviews and focus groups with 165 engineers with multiple logistic regression models from responses to a national survey of over 2,000 engineers, we compared and contrasted engineers' personality traits and motivations to study engineering. Results – Results indicated that EWB-USA members and non-members both exhibited strong engineering personality traits and intrinsic engineering interests and motivations; however, results also indicated that EWB-USA members showed significantly stronger personality traits for openness to experience and agreeableness, higher motivations for social good, and broader interests than non-members.


A computer model which simulates the operation of a flow-through Raney nickel powder electrocatalytic hydrogenation reactor for the synthesis of sorbitol from glucose with simultaneous H[sub 2] evolution has been developed. The model utilizes porous electrode theory, considers both mass-transfer and surface kinetics effects, and contains no adjustable parameters. Hydrogen evolution on Raney nickel is described by a Volmer-Heyrovsky rate expression. The rate equation for glucose hydrogenation is identical to that for the chemical catalytic synthesis of sorbitol with pressurized H[sub 2] gas. For constant-current reactor operation, computed sorbitol current efficiencies match well with experimental data for a range of current densities (0.0053 to 0.021 A/cm[sup 2]) and glucose feed concentrations (0.4 to 1.6M), with an average error of 8.8%. Calculations show that a large fraction of adsorbed hydrogen on the nickel cathode surface is produced by the oxidation of electrogenerated H[sub 2] via the backward Heyrovsky reaction. According to the model, significantly higher sorbitol current efficiencies can be achieved by pulsing the current to the reactor.


The present invention discloses a kind of collocation method of IP address, apparatus and system, is related to computer information technology field, can save temporary ip address by discharging no temporary ip address in time, improves node loading efficiency, and ensure to communicate successfully.The embodiment of the present invention sends DHCP request message by Dynamic Host Configuration Protocol server, and the dhcp message is used for acquisition request IP address;The IP address of the Dynamic Host Configuration Protocol server transmission and the attribute-bit of IP address are received, it is fixed ip address or temporary ip address that the IP attribute-bits are used for the IP address;The IP address type recognized according to attribute-bit is temporary ip address, by temporary ip address release.The embodiment of the present invention is suitable to carry out the NIC in server used when configuring IP address in loading procedure.


In this paper, the magnetic and thermal analysis of a Halbach PM eddy current brake is carried out. Firstly, the analytical model of the Halbach PM eddy current brake is deduced, and the veracity of the analytical model is verified using the 2D FE magnetic field simulation. Then, the FE magnetic field results are used for the 3D FE thermal simulation to get the temperature distribution of the eddy current brake. Finally, the temperature rise of the parts of the eddy current brake effect on the performance of the Halbach PM eddy current brake is analyzed.


By experiments on retention, which is defined as the fraction of the radioactivity resisting aqueous extraction, we find, for propyl bromides irradiated in paraffin at a distance of two centimeters from the source with unfiltered neutrons: R(Br80(18 min))R(Br80(4.4 hr))Normal propyl bromide0.72±0.050.85±0.05Isopropyl bromide0.37±0.020.58±0.03The different sources of error are examined and eliminated.The addition of free bromine, with the purpose of blocking the impurities, left a difference in the retention of the two isomers.An interpretation is suggested.The percentage of Br(18 min) of isomeric transition in the free state proceeding from Br(4.4 hr) in the bound state, is found to be 16 percent for the normal propyl bromide and 40 percent for the isopropyl bromide.


Prof Peter Ferenci opened the meeting by providing a background to Wilson disease (WD), an enigmatic condition where no two cases are the same. He explored the aetiology, peak age of presentation, and long-term outlook.

Dr Gideon Hirschfield considered the wide variation in WD symptom presentation, the lack of a diagnostic gold standard, and the difficulties around choosing WD endpoints for clinical trials. He went on to consider how study endpoints have evolved over time, and how, in real-life clinical practice, therapies need to be tolerable for patients with negative copper balances.

Prof Anil Dhawan focussed on diagnostic challenges in paediatric WD, reviewing the size of liver biopsies needed for measurement of liver copper dry weight, the penicillamine challenge test, and Leipzig scores. Regarding treatment, he stressed that improvements in liver scores take time on chelation therapy, making it important not to rush patients to transplant. Prof Dhawan explored the development of disease severity scores for transplantation, including the revised cut-off points for the Nazer score. He provided reassuring data around the success of living related liver transplantation from parents heterozygous for WD and raised the possibility of auxiliary liver transplants.

Prof Karl Heinz Weiss considered three WD cases reflecting different aspects of the condition. The neurological case showed deterioration of neurological symptoms after starting D-penicillamine. This, Prof Weiss speculated, may relate to treatment causing shifts in the copper pool from bound copper to unbound copper. The second case involved a young woman with WD who was planning a pregnancy; Prof Weiss showed the importance of patients remaining with therapies they are used to. Finally, he considered a patient with decompensated cirrhosis referred for liver transplantation but for whom, when reassessed with the modified Nazer score, the level did not indicate the need for transplantation. The patient showed side effects with one treatment but subsequently did well on a second treatment and was delisted for transplant.


A tube well and technologies for drainage, pressure reduction and dewatering pertain to the technical field of construction; the technical problem, the process optimization of the well points of a deep well dewatering function, is required to be solved; the tube well comprises a well pipe, a top-to-down vacuum pump, a filtering pipe, a submerged pump lower than the bottom of a foundation pit in the tube well, a top-to-down water-resisting clay for hole sealing, filter materials and water-resisting clay and filer materials lower than the foundation pit bottom outside the tube well, the invention also comprises a tube well water stopper inside the well pipe and below the submerged pump which meets the depth requirements of the submerged pump, matches with the diameter of the tube well and has the functions of easy adjustment and setting of depth and flexible water interception effect response. At the stage of drainage and dewatering stage, the water interception function of the water stopper is activated to facilitate the drainage and dewatering; and at the pressure reduction and dewatering stage, the water interception function is removed to realize the pressure reduction and dewatering of a confined aquifer. The invention has the advantages of lowing project cost, saving resources, accelerating construction progress, facilitating inside foundation pit operation, safe construction and easy operation.


Preface Foreword by Ian McDonald Introduction by Adam Zeman and Linda Emanuel 1. What are ethics? By Anthony Grayling Diagnosis and communication 2. To tell or not to tell?: the problem of medically unexplained symptoms by Simon Wessely 3. Should the diagnosis of Alzheimers disease always be disclosed? by Robert Howard 4. When, if ever, should confidentiality be set aside? By Jessica Wilen Berg 5. Should consent be required for an HIV test? By Rebecca Dresser 6. Should we offer predictive tests for fatal inherited diseases and, if so, how? by Susan M Wolf and Thomas C Horejsi Therapy 7. Why, and how should trials be conducted? By Richard I Lindley and Charles P Warlow 8. How should we test and improve neurosurgical care? By Grant Gillett 9. Embryos and animals: can we justify their use in research and treatment? By Peter Singer 10. Who should receive and who dispense expensive treatments? By David Bates 11. Why and when may treatment be enforced? By Anthony Hope Funding and conflicts of interest 12. Does private practice threaten public service or enhance it? By Ian R Williams 13. The Gulf War Syndrome and the military medic: whose agent is the physician? By Edmund G Howe Last things 14. Is the concept of brain stem death secure? By Calixto Machado 15. When-- if ever-- should treatment be withdrawn? By Christopher D Ward 16. Must we always use advance directives? By Linda Emanuel 17. When-if ever-should we expedite death? By Diane E Meier, Hattie Myers and Philip R Muskin


s of 16th Annual Meeting 345 development. It is characterized by problems with reading and spelling which may be related to the impaired phonological processing skills also found in this population. Children with dyslexia often present with problems in language processing, articulation, and verbal memory. More recently, some authors have noted deficits in executive functioning in this population. The cognitive literature has demonstrated a direct relationship between measures of speech rate and verbal memory span; the faster one talks, the more items he or she can retain. It has also shown a positive relationship between measures of phonological processing and verbal memory. The clinical neuropsychological literature has demonstrated a relationship between reading deficits and reduced verbal memory span in children with dyslexia, but has yet to focus on the contribution speech rate, phonological processing skills, and executive functioning make to explaining this reduced span. One of the goals of the current study was to investigate the nature of the relationship between short-term verbal memory as measured by the Wide Range Assessment of Memory and Learning (WRAML) and measures of speech rate, phonological processing, word fluency, reading ability and VIQ in children with dyslexia. The sample included children between the ages of 9 to 13 who had been diagnosed by their school system as having a learning disability in reading. The backwards regression statistic was utilized to investigate the degree to which the measures of speech rate, reading ability, WISC-III VIQ , Woodcock-Johnson-Revised Word Attack (WJ-R WA), and the Benton Word Fluency test (BWF) predict measures of short-term verbal memory from the WRAML. Preliminary results suggest speech rate successfully predicted both Sentence Memory and the Verbal Memory Index, explaining approximately half of the variance of these two measures. Verbal Learning was predicted by reading ability and the WJ-R WA subtest, while Number/Letter memory was predicted by reading ability and BWE None of the variables entered into the equation were successful predictors of Story Memory. It is interesting that the relationship between measures of verbal memory and measures of speech rate, phonological processing, word fluency and reading ability was able to be replicated when using subtests which measure memory for sentences, lists of words, and number/letter strings. However, none of the expected relationships held for memory for stories. This may be because the Story Memory subtest provides a great deal of context to aid children's memory. Previous research has demonstrated that children with dyslexia are better able to retain semantic information. The other three subtests do not provide as much context, and therefore, may be more affected by deficits in these skills. In summary, this study has demonstrated a positive relationship between measures of short-term verbal memory and measures of speech rate, word fluency, and phonological processing by utilizing tests more commonly used by clinical neuropsychologists. This was true for measures which did not provide as much context, but not true for memory for stories It appears that children with dyslexia are more able to compensate tbr their deficits when they are provided with material to recall which has a greater semantic base. Kindermann, S. S., & Brown, G. G. Depression and Memory in the Elderly: A Meta-Analysis. The literature regarding the effects of depression on memory in the elderly is equivocal; some researchers claim little or no effect of depression on memory while others hold the opposite view. This is an important conflict to resolve, if possible, because of the thorny problem of differentiating clinically between the diagnoses of dementia and dementia syndrome of depression. To that end, a meta-analysis of studies (n = 40) of depression's effects on memory in the elderly (sample mean age -> 55) examined variables potentially accounting for the literature's divergent findings. The distribution of effects was bimodal; effect sizes were heterogeneous. Compared to controls, groups containing unipolar subjects only were significantly less impaired than mixed unipolar-bipolar groups (unipolar d = .58; mixed d = Downloaded from https://academic.oup.com/acn/article-abstract/12/4/344/3735 by guest on 29 July 2018


mining map digitizing of various types of coal mining map digitizing processing new technology, is to establish a modern mine enterprise's essential condition and basic construction. Around the mine map digitization concept, put forward five kinds of digital mine map method and its application conditions, for all types of mining enterprises in accordance with the actual conditions of use. Key words-mine map; digital engineering; design; CAD In the coal production of our country, most design of coal mine and mining are still need to be completed by using the traditional manual drawing method, it not only has low efficiency, high cost, but also affects the establishment of information and digital business process. I. the main problems in the traditional map processing The traditional mine map processing and mining design work need to complete by lots of people, so the main problems are: design 1 of drawing has a slow speed and long cycle; 2workload of the repeat drawing is heavy. The partial drawings of the coal mine production or the drawings of most of the contents are repeatable, in each drawing the repetitive content should be redrawn, so it wastes a lot of manpower and man-hour; 3 the quality of the drawing paper is bad, standardization degree is low;4 the drawings have low precision. Drawings of manual design generally have low precision and errors, some errors will bring the serious production problem; 5utilization rate of the drawings is low , it is not easy to preserve, communication and management; 6the high cost , low efficiency and poor benefit . II. definitions of mining map digitizing and software


In article the priority directions of formation of a modern labour market model in Russia are considered. The main lines of a socially oriented labour market and the conditions causing its transformation come to light. The system changes necessary for initiation of progressive tendencies in this sphere are defined.


This paper describes work the Open Language Archives Community (OLAC) is doing to contribute to a global infrastructure for the sustainability of language resources. After offering a definition of language resource, it addresses the issue of what makes language resources sustainable by defining six necessary and sufficient conditions for their sustained use, then discusses what it takes to make such sustainability a reality by describing the roles of four key sets of players—creators, archives, aggregators, users. With this background, the paper describes the community infrastructure OLAC has developed for allowing its members to express consensus about best practices for digital archiving, plus the technical infrastructure it has developed to provide aggregation and search for the language resources community. The concluding section probes the broader issue of sustainable development to consider the sustainability of language resources in the context of the sustainability of language development and of languages themselves.


Foreword: Stuart Hall. 1. Approaching Sport and Power. 2. The Repression and Reform of Popular Sporting Forms. 3. Consolidating the Bourgeois Model. 4. Sport and the Remaking of the Working Class. 5. Sport and the Recomposition of the Working Class in Modern Britain. 6. The Commercialization Process. 7. Media Sport. 8. Schooling the Body. 9. State Intervention. 10. Sport and Hegemony. Index.


SUMMARY: This is the first study to describe CSF-venous fistulas involving the sacrum, a location that may be underrecognized on the basis of current imaging techniques. We describe a delayed decubitus flat CT myelogram technique that may be useful to identify sacral CSF-venous fistulas.


This paper classifies data on the work performance of Jeonnam police by time during the May 18 Democratic Movement and examines whether it was legal in light of the current law related to the duties of police officials at the time. To this end, based on testimony from the Jeonnam Provincial Police report produced in 2017, this research analyzes how the Jeonnam police suppressed protests before the mass firing happening on May 21, 1980, decided to evacuate weapons, and how they performed their duties in the process of unit dissolution and return after the mass firing. As a result, it can be seen whether the Jeonnam police had limitations due to martial law in performing their duties at the time of May 18, but they actually set an example for the exercise of just public power to prioritize the safety of the sovereign people in a passive way of refraining from violence such as weapon evacuation and unit dissolution.