−Methods for regenerating H3PW12O40 catalyst in the solvent-free direct preparation of dichloropropanol (DCP) from glycerol and hydrochloric acid gas were investigated. Regenerated H3PW12O40 catalyst was then applied to the solvent-free direct preparation of DCP. In the solvent-free direct preparation of DCP, selectivity for DCP over H3PW12O40 catalyst regenerated by method I (recovery of solid H3PW12O40 catalyst by evaporating homogeneous liquidphase product solution) significantly decreased with increasing recycling run, while that over H3PW12O40 catalyst regenerated by method II (regeneration of H3PW12O40 catalyst by oxidative calcination of solid product recovered by method I) was slightly decreased with no significant catalyst deactivation with respect to recycling run. On the other hand, selectivity for DCP over H3PW12O40 catalyst regenerated by method III (regeneration of H3PW12O40 catalyst by recrystallization and subsequent oxidative calcination of solid product recovered by method II) was the same as that over fresh catalyst without any catalyst deactivation with respect to recycling run. Thus, method III was found to be the most efficient method for the regeneration of H3PW12O40 catalyst.


On the background of mixed
ownership reform, the equity mix has an increasing impact on corporate
performance. Our research selects the panel data of 620 Shanghai and Shenzhen
A-share manufacturing listed companies from 2015 to 2019, and constructs a model of the mediating effect of "equity
mix-executive incentives-corporate performance" to test the impact of equity
mix on firm performance, and further explore the mediating effect of executive
incentives between the equity mix and firm performance. Research shows that:
the "U"-shaped relationship between equity mix and company performance is
confirmed, executive compensation incentives have a partial mediating effect
between equity mix and firm performance, and executive equity incentives have a
complete mediating effect between equity mix and company performance.


The prediction of rate-dependent compressive strength of rocks in dynamic compression experiments is still a notable challenge. Four machine learning models were introduced and employed on a dataset of 164 experiments to achieve an accurate prediction of the rate-dependent compressive strength of rocks. Then, the relative importance of the seven input features was analyzed. The results showed that compared with the extreme learning machine (ELM), random forest (RF), and the original support vector regression (SVR) models, the correlation coefficient R2 of prediction results with the hybrid model that combines the particle swarm optimization (PSO) algorithm and SVR was highest in both the training set and the test set, both exceeding 0.98. The PSO-SVR model obtained a higher prediction accuracy and a smaller prediction error than the other three models in terms of evaluation metrics, which showed the possibility of the model as a rate-dependent compressive strength prediction tool. Additionally, besides the static compressive strength, the stress rate is the most important influence factor on the rate-dependent compressive strength of the rock among the listed input parameters. Moreover, the strain rate has a positive effect on the rock strength.


Multilingualism in teacher education – a missing perspective This article is based upon fieldwork within a comprehensive teacher education program. Questions were asked about how student teachers are prepared for work/employment in an educational system, which is characterized by pluralism in terms of multilingualism and a second language perspective? How does one speak about language and pluralism? Is a multilingual perspective in teacher education presented as a competence for some or for all? How do various actors look at "questions of linguistic pluralism"? On the one hand, the result, i.e. the answers provided, can be seen as fairly meagre, but this does on the other hand also tell us something more generally about how issues pertaining to language and pluralism are regarded in a teacher education program. In the categorizations and interpretations that are articulated, perspectives on multilingualism and second langue acquisition (if and when they are mentioned) are in different ways often related to "the Others" and to what can partly be referred to as a deficiency perspective. Similar talk is also heard from teacher education at other sites of learning. These topics are dealt with in the first part of the article. Thereafter follows a section about viewing multilingualism in a more general perspective, where multilingualism is also regarded as an asset – here we encounter above all various actors within the field of linguistics. Didactic aspects as well as identity and social categorization are highlighted. At the end of the article, a concluding and more comprehensive discussion about multilingualism and a second language perspective, which also focuses on steering / policy documents, is brought to the fore. Teacher education appears to be fairly national(ist) in spite of recurring talk about increasing globalization and internationalisation. To jointly regard multilingualism and intercultural education as a part of a democratic process is conspicuous by its absence. In this discussion, which also comprises the governmental inquiry, from 2008 - En hallbar lararutbildning (A sustainable teacher education, SOU 2008: 109) – attention is given to a transnational perspective on education and competence.


The present invention relates to the field of packaging, in particular to a container, and constitutes a vessel made from polyethylene terephthalate (PET) which is intended for filling with aerosols. The technical problem addressed by the invention is that of increasing the operational strength of cylinders made from PET for aerosols by changing the design of elements of said cylinders, namely the base and the neck. The technical problem of interest is solved in that, according to a first alternative, in a cylinder made from PET for aerosols, the cylinder comprising a neck and a body with a base, the base has radial grooves, and the edge of the neck is equipped with an outwardly projecting, annular, right-angled bead forming a flat end of larger diameter, wherein the width of the wall of the neck together with the bead is approximately equal to the height of the bead, while, according to a second alternative, the cylinder comprising a neck and a body with a base, the base has radial grooves, the neck is equipped with an outwardly projecting, annular bead which is arranged on a lateral surface offset from an upper edge which, in longitudinal section, is virtually semicircular in shape, wherein the upper half of the bead is bevelled inwards to the edge of the neck, and an annular groove with a concave surface is formed level with the bead inside the neck. In a preferred alternative embodiment of the cylinder, the radial grooves on the base can be widened and deepened from the centre to the periphery, forming a petaloid base, and the wall of the body can have a thickness of 0.3 mm to 1.2 mm.


This study is to find out the residents' attitudes for the components of home environment. This study proceeded with purposes 1) to define the components which are used to evaluate home environment and 2) to suggest the profile of home environment by analyzing the rate of significance and consideration for them. A survey was conducted by 511 housewives who live in Pusan, and analyzed by using frequency, percentage, mean, factor analysis, t-test, one-way ANOVA and Scheffe's test. The major findings are as follows: 1) The 16 elements were selected as the components which are used to evaluate home environment. 2) As for residents' attitudes, the profile of the rate of significance and consideration for the components showed generally high as over 3.0(mean) in all elements. 3) A comfortable environments, safety, housing atmosphere, traffic environments and educational environments were found out as elements that were very significantly recognized and considered in the profile. 4) As for residents' attitudes according to housing and household characteristics, there was a difference in a few elements.


A private Toronto-area fertility clinic that is offering women the chance to freeze their eggs for a decade or more is opening up a new thread in the contentious debate over fertility treatments and technology.

ESRM Biotech is the first private clinic in Canada offering to freeze either sperm or


The oxidation of primary, secondary, allylic, and aromatic alcohols to the corresponding carbonyl compounds proceeds in high yield catalyzed by molybdenum(VI)–peroxo complex with H2O2 under solvent...


Our hypothesis is that speakers under the influence of alcohol produce more linguistic/phonetic errors because of the negative effect of ethanol on cognitive processes and speech motor control. We examined the speech of 150 German speakers of both genders with regard to rates of 6 types of disfluencies and 2 durational measures. The intoxication of speakers ranged from 0.050% to 0.175% blood alcohol concentration; other factors investigated are speaker gender and speaking style (read, spontaneous, commandc gender has no influence; individual speakers deviate from the general trend frequently. We conclude that for forensic investigations disfluency rates should be applied with greatest care (i.e. individual speaker only), and command&control speech as typically used in automotive systems is not suitable for the automatic detection of intoxication on the basis of disfluency rates.


This study was aimed to investigate tactile and audible warning produced by different configuration of transverse rumble strips (TRSs) installed on a two-lane highway. The eighteen different patterns of rumble strips with different thickness, width of each strips, and gap between strips, were examined. The rumble strips were tested with a test vehicle, which was a pickup truck, at different speeds. It was found that as speed of vehicles passing over the TRSs increase, the roadside sound and in-vehicle sound also increase. On the other hand, changes in in-vehicle vibration decrease as vehicle speed increase. Considering the thickness of TRSs, thicker TRSs caused bigger change in in-vehicle sound and in-vehicle vibration. The Department of Rural Roads' (DOR) configuration TRSs seem to provide adequate in-vehicle sound difference and in-vehicle vibration difference for driver to be clearly notified. In comparison with DOR's configuration TRSs, the TRSs with 25 cm-gap (W10G25T0.5) seems to be more efficient in terms of speed reduction and making larger change in in-vehicle vibration.


IN A PREVIOUS STUDY,1 I attempted to document the basic restrictions affecting New York employment patterns for the Negro in the period 19201964. In that study it was shown that the Negro is still the last man in and the first man out in industrial and commercial employment. While various groups in America suffer from economic restrictions, it should be clear that for the Negro the specific economic restrictions applied to him are devastating because they plague him during the whole span of his working life; and they affect virtually all Negroes, from the adolescent Negro searching for his first job, to the much older Negro attempting to hang on to his job until he is eligible for social security benefits. It should be stressed that although the economic aspects of this progress are primary, the psychological aspects complement the economic and sociological by an equally vicious pattern of subjective relations beginning with disappointment which, in turn, forges bitterness, hatred, and apathy.2 One study covering the 1930's, specializing in Negro youth, found that the bulk of colored youth was unemployed from 50 to 100 per cent of the time after leaving school. Furthermore, the study stressed that economic mobility of colored youth, compared with white youth of equal education, was narrowly limited. The authors concluded that Negro youth was always shunted into part-time and short-time jobs and had to accept this employment pattern or be without employment.3


The crystalline samples of Barium (Ba) doped Sr10-xBax(PO4)6(OH)2 with x = 0, 0.5 and 1 mol% were prepared by co – precipitation method. The microstructural (SEM) image shows the distribution of densely packed grains over the surface of prepared sample. The nature of cole – cole plots confirm that the conduction mechanism is governed only by the grains with no contribution of grain boundaries for all prepared samples. The resistance of grains decreases with increase in temperature and molar (mol%) concentration, which shows a negative temperature coefficient resistance (NTCR) behaviour for all prepared samples. The a.c. conductivity increases with increase in frequency which shows non – debye nature of the prepared samples.


This paper deepens the nonsense poetry theme with a specific reference to Jab-berwocky's poem, in Lewis Carroll's Through the Looking Glass (1871) and the creative use of portmanteau-words. It emerges that nonsense poetry is not just a reverie, but one of the many profiles with which children's literature is still ex-pressing today with significant results on the ludic and aesthetic level. This con-cerns the pedagogical investigation as it is an effective opportunity to redefine the experience from the unusual, from the possible and – utopically – from the impossible.


In Australia, community art has drawn significant research attention in regard to its potential as a community development strategy. Despite the fact that researchers have presented evidence for the positive developmental outcomes of participation in community art projects, a gap remains in understanding how and why people's participation in a community art project can lead to those positive outcomes. This research explored the meaning of participation in a community art project from the vantage point of the people who experience it. Ten participants were interviewed about their participation in a community art project (The Seeming) held in Bendigo, Australia. Following thematic analyses we identified three themes of how participants viewed their participation in a community arts project. These themes included giving voice to the silenced, creation of social connections and challenging and reproducing stereotypes. Participation means coming together and the findings highlight the potential of community arts projects for promoting the creation of new relationships and new stories about community. However, there are also problematic stories about self and others that were not deconstructed. It is argued that the settings in which different groups join can be meaningfully extended if there is an explicit concern with consciousness raising and deconstruction of normative stories. Copyright © 2010 John Wiley & Sons, Ltd.


In order to monitor and warn the leakage fault of air control valves in train braking system, rapid analysis of fault characteristics is the key premise. The relay valve used in train braking system was taken as an example in this paper. Its working principle and physical structure were clarified, and the leakage fault was divided into internal leakage and external leakage based on the airflow direction. The simulation model of relay valve was established, and the internal and external leakage faults were simulated by using the model-based fault injection method. The influence laws of leakage faults on the output pressure and balance state of the relay valve were analyzed, and it was found that the relay valve had a dynamic balance position besides the tri-state position. Finally, the leakage simulation bench test was carried out, and the test results show that the relay valve model could correctly analyze the leakage fault characteristics, and the output pressure could be used as the fault characteristic to warn leakage faults. The method proposed in this paper provides an effective way to analyze the fault characteristics of braking system and can be used to obtain fault data for fault diagnosis.


This paper conducts a comparison between direct and indirectly liquid-cooled topologies for coreless linear motors with multiple coil layers. The electromagnetic force production is obtained by 3-D magnetic scalar potential modeling whereas thermal modeling is performed by 3-D finite element and volume methods. The power dissipation and force density of each topology is investigated for different pole pitches and coil configurations. Subsequently, localization and comparison of the magnetic and thermal stresses is performed for both topologies. Furthermore, variations in the geometry are investigated to mitigate mechanical stresses.


It is found that the endonuclease inhibits the growth of the eukaryotic cell culture of Saccharomyces cerevisiae, which is especially expressed under the conditions leading to the disintegration of the cell wall. In particular, a 15-minute incubation in the presence of the endonuclease is shown to suppress the culture growth, two times reducing the number of colony-forming units. A 15-second incubation in the presence of initial "Betadine" and "Betadine" diluted 100 times (0.05-5% povidone-iodine) leads to a complete loss of the viability of the culture. A 500-1000-time dilution of "Betadine" (0.005-0.01% povidone-iodine) saves the culture's viability, which in comparison with the control is reduced by 30-45% after a 3-6-minute incubation. The combined action of diluted "Bethadine" and the nuclease two times enhances the suppression effect on the culture growth.


Following its original description, which was accompanied by an illustration in the Flora Brasiliensis (Nees 1847a), Eurychanes verbasciformis Nees has remained in obscurity for almost 150 years. The monotypic genus Eurychanes, together with ten other genera recognized by Nees and classified in the Acanthaceae tribe Ruellieae by him (1847a, b), were all included in the genus Ruellia by Bentham (1876) (see Ezcurra 1993, for a summary of the complex taxonomic history of Ruellia). However, Eurychanes verbasciformis was never formally combined, perhaps because Bentham was unable to examine any material of this species. Lindau (1895) followed Bentham and also treated Eurychanes as a synonym of Ruellia, but likewise did not publish the new combination for the species. Modern taxonomic works on neotropical Ruellia species (Daniel 1995, Ezcurra 1993) accept the taxonomic delimitation of Ruellia that includes Eurychanes, but as these cover Mexico and southern South America, they do not treat this particular species.With the recent rediscovery of populations of this species in Central Brazil, the need to make a new combination arises:


In 1974 the United States Department of Health, Education and Welfare issued a profound set of ethical guidelines for the protection of human subjects participating in experiments.1 These guidelines have become standard within the scientific community. Surely there is nothing anti-scientific in the application of these guidelines. The guidelines require an Institutional Review Board approve experiments on humans. The IRB shall determine whether these human subjects will be placed at risk, and if risk is involved make sure:


The purpose of this project was to reduce setup time on a press machine at Nitator Hylte AB and to develop a Standard Operating Procedure (SOP), which will serve as a basis for the operators to car ...


A broadband parameterization that improves the quantitative estimates of the solar radiative characteristics of low clouds is developed using reference solutions. The accuracy of the parameterization in determining the shortwave cloud absorption for a wide variety of low-cloud conditions is better than 20%. Other broadband treatments, which do not adequately account for the influences due to above- and in-cloud water vapor and water drop extinction, are also considered to investigate the sensitivity to these factors. The computed northern hemisphere summertime fluxes reveal that (1) the absorbed solar flux in low clouds (Fabs) is overestimated at high latitudes if the effect of attenuation by the above-cloud vapor is ignored in the determination of the water drop absorption, (2) Fabs is underestimated in the tropical regions if in-cloud vapor absorption is not considered, and (3) the conservative scattering assumption for drops yields a substantial underestimate of Fabs at most latitudes. General circulation model simulations with fixed sea surface temperatures and cloud amounts further highlight the significance of the vapor and drop optical properties. Differences in the broadband treatment of the radiative interactions with vapor and drops in low clouds introduce changes in the solar fluxes absorbed by the atmosphere and the surface; for the cases considered here, the solar flux change at the top of the atmosphere differs in sign from that at the surface. The flux differences bring about changes in vertical motion and precipitation; these, in turn, are accompanied by perturbations in the various components of the land surface heat (e.g., latent and sensible heat losses) and moisture (e.g., soil moisture, evaporation) budgets. For approximately similar solar flux differences the changes in the vertical motion, precipitation, and land surface parameters are dissimilar in the tropical and the midlatitude continental regions. Thus because of the adjustments in the atmosphere and the coupling between the atmosphere and the land surface processes, solar flux differences due to biases or deficiencies in the radiative treatment of vapor and drops affect the simulation of the hydrologic fields and the heat balance, including the atmospheric and land surface temperatures.


The kinetics of oxidation of aqueous Cr(III) to Cr(VI) by reaction with pyrolusite (..beta..-MnO/sub 2/(s)) were studied in aerated and deaerated solutions at 27/sup 0/C for pH 3.0-10.1, for 10/sup -4.7/-10/sup -3.4/ M Cr(III), and as a function of ..beta..-MnO/sub 2/(s) surface area to assess the possible effects on Cr transport in industrial waste materials. The oxidation of aqueous Cr(III) is not appreciably affected by dissolved oxygen, indicating that Cr(III) reacts directly with ..beta..-MnO/sub 2/(s) to produce Cr(VI) and not by catalyzed reactions with oxygen at the ..beta..-MnO/sub 2/(s) surface. In acidic solutions, the oxidation of aqueous Cr(III) is highly nonlinear with time, possibly because strong adsorption of the produced anionic Cr(VI) species limits the amount of Cr(III) species able to contact active oxidizing sites on the ..beta..-MnO/sub 2/(s) surface. The following expression is derived from the rate data for pH 3.0-4.7 that empirically account for the nonlinear rate by describing the reaction rate in terms of the fraction of Cr(VI) to total Cr, f/sub Cr/, remaining in solution: df/sub Cr/dt (s/sup -1/) = k(AV)(Cr/sub t/)/sup -1/(1.0 - f/sub Cr/)/sup 3.2 (+/- 0.8) for f/sub Cr/ less than or equal to 1.0 where k = 2.0 (+- 1.6) x 10/supmore » -3/ mol x m/sup -2/ x s/sup -1/, AV is the ..beta..-MnO/sub 2/(s) surface area to solution volume ratio in m/sup 2/ x L/sup -1/, and (Cr/sub t/) is the molar concentration of total dissolved Cr. In slightly acidic to basic solutions, the oxidation of aqueous Cr(III) is very slow and is limited by the low solubility of Cr(OH)/sub 3/(s). 19 references, 6 figures, 4 tables.« less


This study utilizes case study research to document and explain how three U.S. county governments use performance measures on debt obligations in their comprehensive annual financial reports and in their annual budget documents. Municipal debt is a critical source of revenue for local governments and is used for construction of roads, schools, and other capital costs. All three counties use data on debt service as a performance measure in their budget; however, the range of clarity of data on measurement of debt service levels to support debt over time varies widely and is worth noting. In addition, it is unclear whether external stakeholders (other than state government) do not pay closer attention to performance measures on debt because the measures and standards are set by the state. Further empirical work is needed to establish evidence in that regard.


There are two types of electron cyclotron resonance (ECR) sputtering systems, DC-mode and RF-mode. In this paper, the properties of zinc oxide (ZnO) film deposited by an RF-mode ECR sputtering system capable of long-term stable deposition are investigated. It is confirmed for the first time that this system is capable of depositing a ZnO film having a sidewall structure without columnar or fibrous grains on an interdigital transducer (IDT)/glass substrate. The ZnO films so deposited were capable of driving the 1.1 GHz fundamental mode in a Rayleigh surface acoustic wave (SAW) without the large propagation loss at high frequencies of conventional ZnO films. Furthermore, ZnO films deposited by this system exhibited 1.7 dB lower insertion loss and a closer agreement between effective electromechanical coupling factors (keff) and the corresponding values calculated with the finite element method (FEM) in comparison with the films deposited by the DC-mode ECR sputtering system.


[852445-82-0] C21H26ClAuN2 (MW 538.86)

InChI = 1S/C21H26N2.Au.ClH/c1-14-9-16(3)20(17(4)10-14)22-7-8-23(13-22)21-18(5)11-15(2)12-19(21)6;;/h9-12H,7-8H2,1-6H3;;1H/q;+1;/p-1

InChIKey = LGBMTOBGVBJTKP-UHFFFAOYSA-M

(Used as a precursor to [Au(OH)(SIMes)] and [Au(NTf2)(SIMes)] and as in situ generated catalyst.)

Alternate Name: [chloro(1,3-dimesitylimidazolidin-2-ylidene)gold]

Physical Data: mp >300 °C.

Solubility: soluble in dichloromethane, chloroform, acetone, and tetrahydrofuran; partially soluble in toluene; insoluble in water, pentane, hexane, and diethyl ether.

Form Supplied in: white solid, crystal structure available.1

Analysis of Reagent Purity: NMR, elemental analysis.

Preparative Methods: several methodologies have been reported for the synthesis of [AuCl(SIMes)] (SIMes = 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene). These procedures can be divided into (i) transmetalation from a metal–NHC (N-heterocyclic carbene) derivative, and (ii) synthesis from the imidazolidinium salt.

Transmetalation:
[AuCl(SIMes)] can be prepared by transmetalation from silver–NHC1 or, more recently reported, copper-NHC complexes.3
Silver Route:
in air, SIMes(HCl (100 mg, 0.291 mmol) and Ag2O (39.6 mg, 0.171 mmol) were dissolved in dichloromethane (50 mL) and the mixture was stirred for 4 h at room temperature to generate in situ [AgCl(SIMes)]. The reaction mixture was filtered and [AuCl(DMS)] (81.5 mg, 0.277 mmol) was added. The mixture was stirred for 3 h and filtered. After the addition of activated carbon, the mixture was filtered through Celite®, concentrated in vacuo, and pentane (10 mL) was added, affording [AuCl(SIMes)] as a white solid. This solid was washed with further portions of pentane (3 × 5 mL) and dried under vacuum. Yield: 72 mg, 51%.

Copper Route:

[CuCl(SIMes)] was prepared by treatment of Cu2O with SIMes·HCl. [CuCl(SIMes)] (188.1 mg, 0.46 mmol) and [AuCl(DMS)] (136.7 mg, 0.46 mmol) were dissolved in dichloromethane (5 mL) and stirred at 40 °C for 1 h. The mixture was filtered through Celite® and the solvent removed in vacuo. The addition of dichloromethane (3 mL) and petroleum ether (10 mL) afforded an off-white solid that was collected by filtration, washed with petroleum ether (3 × 5 mL) and obtained as a white solid. Yield: 225 mg, 90%.

The reaction time of this transformation can be reduced to 5 min when conducted under microwave heating.3 [CuCl(SIMes)] (102 mg, 0.25 mmol) and [AuCl(DMS)] (73.6 mg, 0.25 mmol) were dissolved in dry dichloromethane (1 mL) in a microwave vial. The mixture was stirred and heated in a microwave reactor at 65 °C for 5 min. The mixture was filtered through Celite® and the solvent concentrated in vacuo. Hexane was added to precipitate a white solid that was collected and dried. Yield: 123 mg, 92%.

Synthesis from the Imidazolidinium Salt.
A one-pot synthesis using MAuCl4·2H2O (M = Na, K) as a gold source has been described.4 NaAuCl4·2H2O (55.7 mg, 0.14 mmol), SIMes·HCl (51.6 mg, 0.15 mmol), and Na2CO3 (72.1 mg, 0.68 mmol) were placed in a Schlenk and 3-chloropyridine was added (0.5 mL). The mixture was stirred at 80 °C for 24 h. The reaction was allowed to cool down to room temperature and dichloromethane (1 mL) was added. The mixture was filtered through a pad of silica and Celite® and rinsed with dichloromethane. The solvent was removed in vacuo and n-pentane was added to afford [AuCl(SIMes)] as a white solid that was filtered and dried. Yield: 54.3 mg, 72%. When KAuCl4·2H2O (58.1 mg, 0.14 mmol) was used, the yield increased to 91% (68.6 mg).

[AuCl(SIMes)] can also be prepared using the corresponding imidazolidinium hydrogen carbonate salt.5 [AuCl(DMS)] (13.8 mg, 0.047 mmol) and [SIMes(H)][HCO3] (14.4 mg, 0.039 mmol) were dissolved in THF (0.7 mL), in air. The mixture was stirred at 50 °C for 1 h and filtered over silica. The solvent was removed under vacuum, affording [AuCl(SIMes)] as an off-white solid. Yield: 18.7 mg, 89%.

Very recently, two closely related one-step procedures to synthesize [AuCl(SIMes)] using a mild base have been reported.6, 7 One procedure uses [AuCl(DMS)] as a gold source: a mixture of [AuCl(DMS)] (86.1 mg, 0.292 mmol), SIMes(HCl (100.0 mg, 0.292 mmol), and K2CO3 (40.4 mg, 0.292 mmol) in acetone (1.0 mL) was stirred for 24 h at 60 °C. Then, the mixture was filtered through silica, which was rinsed with dichloromethane (3 × 1 mL). The solvent was concentrated and pentane (3 mL) was added, affording [AuCl(SIMes)] as a white solid that was washed with pentane (3 × 1 mL) and dried under vacuum. Yield: 129 mg, 82%.

A separate methodology uses [AuCl(THT)] (tetrahydrothiophene): a mixture of [AuCl(THT)] (112.2 mg, 0.35 mmol) and SIMes·HCl (119.8 mg, 0.35 mmol) in dichloromethane (15 mL) was stirred for 15 min. A large excess of K2CO3 (691.0 mg, 5.0 mmol) was added and the mixture was stirred for 1.5 h and filtered through Celite®. The solvent was concentrated under vacuum until about 2 mL remained. Then, diethyl ether (10 mL) was added to precipitate [AuCl(SIMes)] that was washed with further portions of diethyl ether (3 × 5 mL) and dried. Yield: 177.3 mg, 94%.

Purification: recrystallization from CH2Cl2/pentane.

Handling, Storage, and Precautions: air, moisture, and light stable. It can be stored for long periods of time. No particular precautions are required.


The review system,appellate system and the re-trail system are important contents of civil procedure relief system.The review system plays an important role not only in protecting the legal right of the relative person,supervising the courts by the relative person,reducing the cost of civil procedure,but also in defending the legal authority of Civil Procedure Law and intensifying the civil procedure consciousness.However the review system established in the Civil Procedure Law enacted in 1991 is not very perfect and the function and the lawmaking purpose of it can not be realized completely.In order to achieve the purpose of the review system,this paper puts forward some suggestions from the legislative point of view.


Effectively engaging students in mathematics discourse is challenging, especially in a language other than the one in which you learned mathematics. Teachers must manage the academic as well as social function of language. In Spanish-English bilingual classrooms in the US, changing the language of instruction to Spanish may not be enough to disrupt entrenched patterns of mathematics participation, resulting in continued marginalization of Latino students. In this article, I describe what our bilingual pre-service teachers (BPST) learned through a mathematics methods class taught in a fifth-grade classroom of a local, urban, bilingual immersion elementary school. I reflect on my experience as a bilingual mathematics teacher educator and analyze BPST reflections on their successes and challenges as they learned to lead mathematics discussions in Spanish while developing attention to power dynamics among their students. Through the field experience, BPST became more comfortable with academic vocabulary in mathematics and using techniques to involve many students in the discussion. Yet they struggled with explicitly positioning Latino bilingual students as important mathematical thinkers in a classroom in which White, English-dominant students tended to participate most in mathematics discussions. Implications for bilingual teacher


Superconductivity and transport characteristics of high-quality wurtzite-structured In- and N-polarity InN thin film on sapphire substrate by metal-organic vapor phase epitaxy (MOVPE) were presented in this study. Single-crystalline InN films with various n-typed carrier concentrations (n = 1 ∼ 6 × 1019cm–3) resulting from nitrogen vacancy (VN) were obtained by changing buffer layers. Superconductivity phase transition at Tc,onset around 3.5 K are observed in both In- and N-polarity InN. This strongly suggest that the superconduc- tivity originate in the In-VN(and/or VN+)-In chain in the a-b plane of InN thin film. Our experimental results show that the nitrogen vacancy in a-b plane of InN thin film must play important roles for the quasi-2D superconducting network in InN system. Temperature - dependent resistance broadening of InN at T < Tc,onset(K) under zero magnetic fields was observed and can be expressed by Kosterlitz-Thouless transition. Details were discussed in this paper. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)


Usage of wireless networks among the users is apparently high. But, efficiency of the network gets decreased because of the challenges in the network. In proxy mobile IPv6 (PMIPv6), the message exchange for location update by any mobile device is established in centralized environment. Here, the messages are sent and received through local mobility anchor with centralized feature. As a result, there is devastating traffic at local mobility anchor which increases the cost of network. Also, the location update in distributed mobility environment is vulnerable to attacks such as false binding update, man-inthe-middle, replay attack etc. Therefore, the development of location update scheme necessitates the security enhancement and reduction in cost. Hence, the present paper proposes a new secure and efficient location update scheme using tokenization. It eliminates the additional message exchanges such as proxy binding update, binding query and acknowledgements between the hosts required in the earlier works. Here, the traffic overhead is controlled by distributing the token of mobile node with mobile access gateway in distributed mobility environment. The security of the proposed scheme is validated using AVISPA – a security model checker. Finally, the analysis of security and performance evaluation demonstrates that the proposed scheme shows better security and significant reduction in the cost of signaling messages and data packet delivery. © 2015 Senthilkumar Mathi and Anbarasi P N. Published by Elsevier B.V. Selection and/or peer-review under responsibility of the organizers of the 2015 Third International Conference on Recent Trends in Computing (ICRTC 2015)


Targeting subunits of BAF/PBAF complexes has been proposed as an approach to exploit cancer vulnerabilities, yet small molecules developed to date have remained largely ineffectual. Here we develop PROTAC degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a bromodomain ligand and recruitment of the E3 ubiquitin ligase VHL. High-resolution ternary complex crystal structures and biophysical investigation guided the rational optimization of ACBI1, a potent cooperative SMARCA2/4 degrader. ACBI1 induced antiproliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in acute myeloid leukemia cells dependent on SMARCA4 ATPase activity. These findings exemplify a successful biophysics and structure driven campaign to degrade targets previously considered undruggable, and pave the way towards new therapeutics for the treatment of tumors sensitive to the loss of BAF complex ATPases. Citation Format: Manfred Koegl, William Farnaby, Claire Whitworth, Michael Roy, Emelyne Diers, Nicole Trainor, Steffen Steurer, Carina Riedmueller, Teresa Gmaschitz, Johannes Wachter, Christian Dank, Michael Gallant, Bernadette Sharps, Klaus Rumpel, Elisabeth Traxler, Romario Lorenz, Oliver Petermann, Peter Greb, Harald Weinstabl, Gerd Bader, Andreas Zoephel, Alexander Weiss-Puxbaum, Joerg Rinnenthal, Heribert Arnnhof, Nicola Wiechens, Meng-Ying Wu, Tom Owen-Hughes, Peter Ettmayer, Mark Pearson, Darryl B. McConnell, Alessio Ciulli. Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3849.


This article discusses the issue of engagement in antenatal parent education for women living in deprived areas. The article focuses on the findings of a local evaluation of a Sure Start parent education programme designed to improve parental engagement with antenatal services. The article discusses the re-orientation of this service, the impact on service users and the implications for professionals. Evidence suggests that this service has been beneficial for those involved and resulted in improved levels of engagement, with 9 per cent of eligible women attending prenatal sessions prior to the introduction of the Sure Start local programme's parent education service and 34 per cent of eligible women attending after its introduction. Despite this, the service only reaches a small proportion of the eligible population. The article also discusses the issue of professional resistance from mainstream services as an unintended consequence of the introduction of the Sure Start local programme and considers the implications of this for effective delivery.


A secure key distribution scheme with phase noise resisting the beam splitting attack in PSK/QNSC is proposed. The highest key consistency rate 98.4% and key generation rate 70.41 Mbit/s are demonstrated over 50 km SSMF.


Four novel two-dimensional silver(I) co-ordination polymers of two flexible double betaines with different quaternary ammonio side groups in the adipic acid skeleton, namely [{Ag2(L1)}n][CIO4]2n1, [{Ag2(L2)}n][CIO4]2n·2nH2O 2, [{Ag2(L1)(NO3)2}n]3 and [{Ag2(L2)(NO3)2}n]4[L1=meso-2,5-bis(trimethylammonio)adipate, –O2CCH(N+Me3)CH2CH2CH(N+Me3)CO2–; L2=meso-2,5-bis(pyridinio)adipate, –O2CCH(N+C5H5)CH2CH2CH(N+C5H5)CO2–], have been prepared and characterized by X-ray crystallography. Each complex contains dimeric subunits in which each pair of adjacent metal atoms is doubly bridged by coplanar syn-synµ-carboxylato-O,O′ groups. The dimeric subunits are extended into a step polymer through the linkage of each metal centre to a carboxylate group of an adjacent dimer. Such [Ag2(carboxylate-O,O′)2]n chains are extended into sawtooth-wave layer structures in 1, 3 and 4, and an unusual corrugated layer in 2 by the cross-linkage of the adipic acid skeleton of the double-betaine ligands. The different ligation ability of the perchlorate and nitrate anions results in different co-ordination geometries about the silver(I) atoms. In 1 and 2, the silver(I) atom is co-ordinated by three carboxylato oxygen atoms in a T-shaped geometry, and the [Ag2(carboxylate-O,O′)2]n chain exhibits the typical type D structure. The co-ordination geometry of the silver(I) atom in 3 is a distorted tetrahedron, and the [Ag2(carboxylate-O,O′)2]n chain adopts a modified type D structure. The silver(I) atom in 4 exhibits unusual five-co-ordination in a square pyramid, and the dimer is converted into a novel paddlewheel-like structure, which is the first example found in silver(I) carboxylates.


The goal of research is to know the effect Original Local Revenue to Local Budget of Toba Samosir District. The population of research is APBD of Toba Samosir District, by using time series data during 8 years, namely 2000-2007. The object of observation is result of financial report of Toba Samosir district about the Local Revenue and Local Budget in quartal reports for eight years, 2000-2007, consisting of 32 quartals. The financial report for 32 quartals has been made as sampel of the research. Data collected was secondary data and processing of data using Regression Linier Analysis. The result indicated that Local Tax, Local Retribution, and Others Legal Local Revenue has positive effect and sigificantly on Local Budget partially or simultaneously expressed in Coefficient of Determination (R) as 78,5 %, it means Local Budget can be explained by Local Tax, Local Retribution, and Others Legal Local Revenue for 78,5 %, and remaining 21,5 % is effected by another variables Keyword : Local Tax, Local Retribution, and Others Legal Local Reveue. Henri Edison H.Panggabean : Pengaruh Pendapatan Asli Daerah Terhadap Belanja Daerah Di Kabupaten Toba Samosir, 2009 USU Repository © 2008


The investigation of internal stress level in near surface layer of nanoporous metal materials, received by the method of selective laser sublimation, is executed. Researches of copper zinc alloy specimens were spent with use of diffractometer DR 01 «Radian». It is established that as a result of selective laser sublimation in near surface nanoporous layer relative internal stress about 11·10 3 is formed, that at investigation of main temper for planar stressed state condition corresponds to value σ = 2,8 GPa.


Memory, historical policy and historical museums have become very popular in recent times – both in academic discourse and in public debate. The article describes the role of historical museums in collective memory and the influence of historical policy on them. The text includes a definition of collective memory , its traits and functions, a categorization of memory vehicles , as well as an explanation of the concept of historical policy and its positive and negative aspects. In the part dedicated to historical museums the author shows their importance for collective memory, their connections with historical policy, their beginnings and present-day importance in Poland, and provides a review of the last years' main investments in Polish historical museums.


Test generation for hard-to-reach states has been one of the hardest tasks in functional verification. In this paper, we present PACOST, a PAth Constraint Solving based Test generation method which operates in an abstraction-guided simulation framework to cover hard-to-reach states. PACOST combines concrete simulation and symbolic simulation in a path constraint solver to generate a set of valid input vectors for exploring different simulation paths, followed by next state selection considering abstract distances. In addition, two backtracking strategies are proposed to alleviate the dead end problem and ensure fast converge to the target state. Experimental results show that PACOST is effective in covering hard-to-reach states.


Arar industrial area of a regional law number 11 of 2012 concerning General Spatial Plan (RTRW) Sorong years 2008 to 2028 has been set as an industrial area with an area of 6000 hectares; Sorong regency has the potential of abundant natural resources, it is necessary to take advantage of the potential that exists for the sake of improving the local economy. The purpose of this study is identify what type determination commodity criteria of superior products, and determine what types Kalster right industry to be developed in the Industrial Area Arar. By using three methods: Delphi method to know the opinion of the expert / experts representing multiple stakeholders in the area and some professors skilled in the art that amounted to 10 respondents, as well as to calculate the specific gravity of the criteria of superior products through AHP (Analytical Hierarchy Process) through Exel, and calculating sector product base area was conducted using LQ (Location Quotient). So the results of analysis of Delphi obtained nine types of product criteria seed, and after it was done weighting through AHP and determination of value through the Delphi method to the base product is calculated through LQ of the obtained type of cluster that can be developed in an industrial area Arar Sorong is Cluster industi Ranch.


Considering actuality of fluorine-containing textile finishing agents in China,a fluorine-containing textile finishing agent emulsion was prepared by core-shell emulsion polymerization and characterized by FT-IR and laser granularity analysis.The stability of fluorine-containing textile finishing agent emulsion was tested.The effects of cross-linking agent on oil-and water-repellency,and durable-washing properties of the fabric were studied;Air permeability and tearing strength of the treated fabric were analyzed.The results showed that decreasing the size of finishing agent emulsion improves the stability.The textiles had good oil-and water-repellency and washing fastness properties after finishing,and exhibited little change in air permeability and tearing strength.


By the result of thermogravimetric(TG) analysis of the composition, two kinds of perovskite type (La_(0.6)Ca_(0.4)CoO_3Ⅰ), La_(0.6)Ca_(0.4)CoO_3Ⅱas the catalyst for oxygen reduction in air electrode was investigated by solid state redox action at high temperature. The results examined by means of X-ray diffraction (XRD) show that them are perovskite type structure.Constant current discharge and cyclic voltammetry of them in 9 mol/L KOH were tested. The results show that the perovskit type catalyst(La_(0.6)Ca_(0.4)CoO_3) is an excellent catalyst for zinc-air(oxygen) battery, and the properties of catalysts La_(0.6)Ca_(0.4)CoO_3Ⅱare better than that of La_(0.6)Ca_(0.4)CoO_3Ⅰ, such as the discharge capacity,the discharge capacity of (La_(0.6)Ca_(0.4)CoO_3Ⅱ) is (1.2) times of the discharge capacity of (La_(0.6)Ca_(0.4)CoO_3Ⅰ).


These developments have raised questions about what role the CRA should play in financial services regulation, and to whom the CRA ought to apply. In response to the call for a re-examination of the CRA, the Federal Reserve Banks of Boston and San Francisco are jointly preparing a publication that captures the views of some of the leading thinkers on the future of the CRA. The contributors, who include bankers, community-based organizations, and academics, offer a broad range of observations and proposals. While the publication will be available under separate cover in February, 2009, the authors of this article have identified a set of themes and key questions that emerge from these analyses and commentaries. These themes and questions are not policy proposals, or descriptions of a particular solution. Rather, they are an extended range of questions for policymakers and market participants to grapple with as they consider the future of the CRA.


The acute alcoholic inmate of a county or city prison presents special problems of management. The boisterousness, hallucinosis, nausea, tremors, and involuntary defecation and urination, which characterize the postalcoholic state, are not only distressing to the prisoner but also add to the general disturbance of the prison population and increase the burden of custodial care. To alleviate these problems, a simple regimen, effective in controlling withdrawal symptoms in the alcoholic prisoner, is desirable. In recent years, a number of the so-called tranquilizing drugs have been employed in the treatment of the alcoholic patient. Some of the most effective of these drugs in treatment of patients in the postalcoholic state have been the phenothiazine derivatives. 1 Recently a new phenothiazine compound, triflupromazine hydrochloride, has been made available for trial in controlling symptoms of alcohol withdrawal. For about a year, triflupromazine, supplied as Vesprin, has been under study at the Denver city


Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosome (vesicular system). Designing of the drug in the vesicular system has brought a new life to the old pre-existing drugs and thus has improved their therapeutic efficacies by controlling and sustaining the actions. Different novel approaches used for delivering these drugs include liposomes, microspheres, nanotechnology, micro emulsions, antibody- loaded drug delivery, magnetic microcapsules, implantable pumps and niosomes. Niosomes and liposomes are equiactive in drug delivery potential and both increase drug efficacy as compared with that of free drug. Niosomes are preferred over liposomes because the former exhibit high chemical stability and economy. Niosome are non-ionic surfactant vesicles obtained on hydration of synthetic non - ionic surfactants, with or without incorporation of cholesterol or their lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosome are promising vehicle for drug delivery and being non-ionic; and Niosomes are biodegradable, biocompatible non - immunogenic and exhibit flexibility in their structural characterization. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections and other microbial diseases. Niosomes can entrap both hydrophilic and lipophilic drugs and can prolong the circulation of the entrapped drug in body. Encapsulation of drug in vesicular system can be predicted to prolong the existence of drug in the systemic circulation and enhance penetration into target tissue, perhaps reduce toxicity if selective uptake can be achieved.


Importance. The relevance of the chosen research topic is due to the scientific study of the effectiveness of the ongoing penitentiary policy at the beginning of the 20th century in Tsarist Russia and Russia during the Civil War.
Materials and methods. The historical and systemic approach made it possible to consider the penitentiary policy of the "two Russias" at the beginning of the 20th century and to trace the effectiveness in the fight against escapes from detention facility. The statistical method showed the number of escapes from detention facility in Tsarist Russia and in forced labor camps during the Civil War. The use of the comparative historical method showed the level of organization of places of detention of different historical eras.
Results and Discussion. The statistics and scale of escapes from detention facility in the Tambov governorate at the beginning of the 20th century are studied. The level of organization of detention facility is studied, taking into account the factor of revolutionary events, the Civil War and the peasant uprising in the Tambov governorate. A comparative analysis of the number of prisoner escapes from detention facility in Tsarist Russia and detention facility in Soviet Russia is carried out on the example of the Tambov governorate.
Conclusion. The practical significance of the study is expressed in the local history study of the penitentiary systems of two eras in Russia with the aim of further compiling a generalized work on a given topic.


A regression model provides a direct statistical test of the impact of new units on existing units in a competitive area while allowing for additional factors that may moderate the causal link. The model is easily accessible to management practitioners. In its simplest form, it is as follows: If Yt is the customer count in month tfor an existing unit, then Yt= a + PjXlt + 8t, where random shocks in period tare indicated by atand the entrance of the new unit by X4t. Under ideal conditions, the estimate of X would indicate the average monthly customer count of the unit exclusive of the effect of the new unit's entry. The estimate P3 ideally indicates the net average number of customers per month that the new unit has absorbed (the existing unit's lost business).


THERAPEUTIC drug monitoring (TOM) programs have been developed in numerous hospitals and clinics in North America and Europe. TOM connotes those therapeutic monitoring activities developed around the technology of serum drug concentration (SOC) measurement, and subsequent dosage adjustment. TOM has been made practical through several developments: elaboration of the .scientific theory of biopharrnaceutics and pharmacokinetics, establishment of SDCpharmacodynamic relationships and toxicity data with important drugs, and commercialization of equipment and procedures for rapid determination of SOC. The cost effectiveness of providing TOM services initially was limited by the time involved to calculate pharmacokinetic data by hand. The recent availability of inexpensive computer hardware and the development of commercially produced pharmacokinetic software has allowed many clinicians, who would not otherwise have the time or ability to produce complex analyses, to perform them quickly and reliably. Any hospital or clinic can now purchase the analytical and computer technology to conduct state-of-the-art TOM. There is now solid evidence to justify intelligently applied TOM. Numerous studies have shown that the use of SOC can improve the likelihood of drug efficacy and help avoid toxicity. It is precisely those drugs with a narrow therapeutic index and significant toxicity that deserve TOM coverage. I Lund has shown that 86 percent of patients with generalized epileptic seizures can be greatly helped when phenytoin SOC is mainained > 15 Itg/ml. 2 Optimal monotherapy can prevent the haphazard institution of polytherapy so common in epileptics. In addition, seizures are a paroxysmal event, and TOM can identify those underdosed patients who in fact are not optimally protected against future seizures or those overdosed patients with neurologic symptoms not correctly attributed to the drug therapy. Antiarrhythmics such as quinidine can produce toxic arrhythmogenic effects easily confused with the very indications for the drug.' In these cases, TDM can prove invaluable in the differential diagnosis and subsequent therapy. Duhme et al. and Jelliffe et al. have shown a reduction in the incidence of digoxin toxicity associated


Due to the presence of uncertainties, errors inevitably arise with the estimations of pile settlement. To properly consider serviceability requirements in limit state design, it is necessary to characterize the performance of commonly used settlement prediction models. In this work, information from 64 cases of long driven steel H-piles from field static loading tests in Hong Kong is utilized to evaluate the errors of three settlement prediction models for single piles: two elastic methods and a nonlinear load-transfer method. Commonly adopted soil parameters recommended in two Hong Kong design guidelines are used to reflect the uncertainty arising from evaluation of soil properties. The model error is represented by a bias factor. A conventional statistical analysis was first conducted to study the variability of model bias. A regression analysis method was then proposed as a supplemental analysis of model bias when only limited test data were available or when the measured settlement data distribute in a large range. Both methods result in very similar mean biases. The mean bias of each prediction model tends to vary with the load level and the bearing stratum at the pile toe; while the coefficient of variation of model bias only varies in narrow ranges.


Extension of microelectromechanical systems (MEMS) into more extreme operating conditions will require a wider range of material properties than are currently available in conventional systems. Successful integration of new materials is dependent on concurrent development of compatible fabrication routes and scale appropriate evaluation techniques. This review focuses on emerging material classes that have potential to replace silicon-based MEMS in elevated temperature applications. Basic silicon mechanical properties and micromachining methods are reviewed to provide context for developing material systems such as silicon carbide, silicon carbonitrides, and several nickel-based alloys. Potential improvements in strength, thermal stability, and reliability are juxtaposed with fabrication, reproducibility, and economic feasibility issues that must also be addressed.


Summary Local windows are routinely used in seismic data and almost without exception the center of the window is aligned with the points being processed. When a point is on an edge, placing the center of the window on the point is one of the fundamental reasons that cause many filtering algorithms to blur the edges. Based on this insight, we use a new Side Window Filtering (SWF) technique which aligns the window's side or corner with the point being processed. The SWF technique is surprisingly simple yet theoretically rooted and very effective in practice. Experiments show that implementing the SWF principle can significantly improve their edge preserving capabilities and achieve state of the art performances in denoising.


Recent investigations of the immunologic reactions which occur in experimental allergic encephalomyelitis (EAE) have supplied evidence for the development of cellular or delayed hypersensitivity in this autoimmune disease. Delayed skin reactions to central nerve tissue preparations have been reported'-' in rabbits and guinea pigs with allergic encephalomyelitis; skin responses to homologous nerve tissue correlate fairly well with the severity of the disease process. Histologic studies of the perivascular lesions which occur throughout the central nervous system indicate that they are comparable to the histologic changes in other delayed reactions. Perivenous infiltration of mononuclear cells with prominent perivascular cuffing and invasion of the parenchyma is commonly observed. Radioautographic studies5 in the rat using tritium-labeled thymidine injected a day or more before lesion formation have demonstrated that the cells in the perivascular infiltrates are hematogenous in origin and may be characterized as medium or large lymphocytes, many of which evolve to histiocytes during active proliferation in the lesion. In severe lesions there may also be invasion by polymorphonuclear leukocytes. Cells of the plasmocyte series appear shortly and the presence of plasma cells containing detectable gamma globulin has been suggested to correlate well with severe disease. Species vary in the prominence of demyelination which appears to relate anatomically to the cellular infiltratione6 The most prominent evidence for the role of cellular hypersensitivity in the pathogenesis of this allergic disease includes passive transfer with lymph-node-cell preparations. However, successful transfer studies, unlike the case in delayed hypersensitivity to tuberculin, have been generally limited to immunologically tolerant recipient animals. Passive-cell transfers have been accomplished between inbred guinea pigs' and inbred rats,* with rat recipients prepared by neonatal injection of donor spleen cellsg and with irradiated rabbit recipients.1° In addition, in vitro studies of the effect of lymph-node cells from sensitized rats on tissue culture monolayers of puppy brain demonstrated the phenomenon of contactual agglutination." In this instance the tissue culture lacked myelinated constituents which contain the inducing antigen in EAE. This reaction may not be similar in nature to tuberculin-type hypersensitivity or tissue cell rejection** since normal lymphnode cells, after incubation with sera from sensitive animals acquired the capacity to agglutinate the cultured cells. Lymphocytes have generally been implicated as the specific cell involved in tuberculin reactivity, the classic example of delayed hypersensitivity. It was early demonstrated that cutaneous tuberculin reactivity could be passively transferred by peritoneal exudate cells containing lymphocyte^.'^ A more direct relationship was established when cells from thoracic duct lymph of tuberculin-positive rabbits and guinea pigs was successfully used for transfer.'* In contrast guinea pig peritoneal exudates almost exclusively composed of granulocytes do not transfer this reactivit~. '~


Complementary cell suppression was the rst and remains a popular method for disclosure limitation of magnitude data such as economic censuses data. We show that, when not solved in a rigorous mathematical way, suppression can fail to protect data, sometimes fatally. When solved properly as a mathematical programming problem, suppression is guaranteed to meet certain conditions re- lated to protecting individual data, but we demonstrate that other vulnerabilities exist. Suppression sacrices both condential


Flexible and stretchable electronics have given this world a splendid opportunity to monitor and manage their own health. This has led to a convenience-based and versatile form of health monitoring, via smart sensors. These smart sensors can be used to measure various health parameters like respiration rate, ECG (Electrocardiogram), EEG (Electroencephalogram), EMG (Electromyography), blood pressure, etc. These portable sensors allow people to monitor their health status more comfortably and adequately, compared to using bulky devices. These smart sensors can be developed due to the advent of nanomaterials and nanoparticles. All thanks to the developments in the domain of nanoelectronics, we can now gauge various physiological parameters anywhere and everywhere. Using nanocrystalline materials not only reduces the size of the system but also increases the stability, sensitivity and response time of the system. Nanomaterials like Graphene, Carbon Nanotubes (CNTs), Silver Nanowires (AgNWs), Carbon Black, etc. are already in use. However, it is CNTs, which can be utilized to fabricate the smart sensors, that are most popular, and in universal demand. These sensors are highly required in the world today. Time or financial constraints prevent people from visiting a hospital for a medical checkup. Additionally, in many countries there is a lack of medical infrastructure, i.e., either the doctor(s) are not present, or medical devices are not available. Such limitations lead to an increase in the death toll, especially for people suffering from heart diseases. Since cardiovascular diseases (CVDs) are unpredictable in nature, they can occur anytime and anywhere. It is imperative for one to have access to medical facilities in order to save himself/herself. In order to bring this system to life, smart materials need to be incorporated in the ECG monitoring systems. In this paper, we review various SWCNT (Single-Walled Carbon Nanotubes) based ECG electrodes.


Educational timetabling is one of the most researched subjects within the range of timetabling problems. There has been a signi cant increase in e cient planning problems within educational timetabling the last couple of decades. In this paper we will highlight some of the main trends and research achievements within educational planning problems. Furthermore it is an aim to make a di erentiation between the di erent planning problems. This survey is concentrated on the four main education planning problems; University Course Timetabling, High School Timetabling, Examination Timetabling and Student Sectioning. Firstly a presentation of educational timetabling and the main components is given. For each problem a description is given with appertaining benchmark data and recent research. The literature presented is mainly solution tested on real-life data or better yet implemented. Summarizing tables for each section are presented to give an overall view of all the literature of this survey.


AbstrcatIn the paper,an approach to load-balancing in the distributed system is discussed and a novel algorithm is brought forward. While scheduling,first,the arrival tasks are classified by the resources to be occupied,and then the nodes in the system are also classified into some types through online calculation. At last,a node in the least loading class is selected randomly and uniformly. The algorithm can avoid the scheduling-pouring effect,and it is adopted in a distributed operating system developed by us.


A new classical electromagnetic analysis is presented suggesting that the Aharonov-Bohm phase shift is overwhelmingly likely to arise from a classical lag effect based upon classical electromagnetic forces. The analysis makes use of several aspects of classical electromagnetic theory which are unfamiliar to most physicists, including the Darwin Lagrangian, acceleration-based electric fields, internal electromagnetic momentum in a magnet, and a magnet model involving at least three mutually-interacting particles. Only when the acceleration-based electric forces acting on the passing charge are included do we find consistency with all the relativistic conservation laws: energy, linear momentum, angular momentum, and constant center-of-mass velocity. The electric forces on the passing charge lead to a lag effect which accounts quantitatively for the Aharonov-Bohm phase shift. Thus the classical analysis strongly suggests that the Aharonov-Bohm phase shift (observed when electrons pass a long solenoid which corresponds to a line of magnetic dipoles) is the analogue of the Matteucci-Pozzi phase shift (observed when electrons pass a line of electric dipoles). The classical electromagnetic analysis suggests experiments to distinguish the proposed classical-based lag effect from the presently accepted view that the Aharonov-Bohm phase shift is a quantum topological effect arising from magnetic fluxes in the absence of classical electromagnetic forces.


Approachability is not only one major factor of the news value, but also an important respect that is not negligible for the research of the law of news. It is especially protruding and important for the Party's newspapers of prefectures and prefectural cities. This paper analyses the connotation of approachability and it relation with other factors and puts forward approaches for the Party's newspapers of prefectures and prefectural cities to realize the approachability.


Climate change (CC) is the greatest environmental, economic and political threat for society. The scientists of the IPCC (Intergovernmental Panel on Climate Change) consider that an increase of 2 °;C with respect to the temperature of the pre-industrial era is the limit for dangerous and catastrophic changes in our planet Earth. For this reason, the international community has recognized the need to improve our mitigation and adaptation policies, where education has an important role as an agent to create awareness, train and mobilize young people in the face of the challenges of Climate Change. Although the role of Education is recognized, it is not fully implemented as a strategic resource. The motivation of this project is to create an objective diagnosis of the current state of formal education on Climate Change, propose new strategies to develop the important tasks that Education must complete on this issue and finally, building new concepts and frameworks to push the role of Education as a real solution. We have introduced the new concept of Climate Competence. which organizes knowledge, awareness and skills. The work also includes creating tools to evaluate the efficiency and fitness of traditional curriculums and new education tools such as online reaching or MOOCs.


University of Minnesota Ph.D. dissertation.August 2014. Major: Family Social Science. Advisors: Zha Blong Xiong, Catherine Solheim. 1 computer file (PDF); viii, 299 pages.


The Mg acceptor activation mechanism and hole transport characteristics in AlGaN alloy with Mg doping concentration (∼ 1020 cm−3) grown by metal–organic chemical vapor deposition (MOCVD) are systematically studied through optical and electrical properties. Emission lines of shallow oxygen donors and (VIII complex)1− as well as VN3+ and neutral Mg acceptors are observed, which indicate that self-compensation is occurred in Mg-doped AlGaN at highly doping levels. The fitting of the temperature-dependent Hall effect data shows that the acceptor activation energy values in Mg-doped AlxGa1 − xN (x = 0.23, 0.35) are 172 meV and 242 meV, and the hole concentrations at room temperature are 1.2 × 1018 cm−3 and 3.3 × 1017 cm−3, respectively. Therefore, it is believed that there exists the combined effect of the Coulomb potentials of the dopants and screening of the Coulomb potentials by a high hole concentration. Moreover, due to the high ionized acceptors' concentration and compensation ratio, the impurity conduction becomes more prominent and the valence band mobility drops sharply at low temperature.


The structural characteristics and infrared temperature measurement technology of dry-type reactor are introduced.The calculation model of temperature field of drytype reactor is established.Based on the finite element software,ANSYS,the temperature field of the dry-type reactor is simulated,calculated and analyzed.The analysis results are presented.


Objective To Investigate the relationship of Hyperfibrionlysis with tissue plasminogen avtivator (t-PA) and plasminogen activator inhibitor (PAI) in patients with liver cirrhosis associated with viral hepatitis. Methods Thirty-five patients (31 men and 4 women; age 27~73years) with liver cirrhosis were divided into three groups, i.e. grade A(10 cases), B(13 cases) and C(12 cases) according Child-Pugh classification. The plasma contents of t-PA antigen, PAI activity, fibrin or fibrinogen decomposition products (FDP), and D-dimer were determind in all the patients. Results Of 22 patients without systemic signs of hyperfibrinolysis, 12 belonged in grade A, 6 in grade B and 4 in grade C. There were significantly difference in plasma t-PA content among grades A (6.02±4.15)ng/ml,B(13.1±6.8)ng/ml and C(22.5±9.3)ng/ml (P0.05),and there was insignificant difference in PAI activity among grade A, B and C in the patient without systemic signs of hyperfibrinolysis (P0.05). There were insignificant difference in t-PA antigen and PAI plasma contents between the patients with hyperfibrinolysis and the patients with normal fibrinolysis (P0.05). Conclusion The plasma content of t-PA antigen significantly increases and the plasma content of PAI activity is insignificantly changed along with the deterioration of the condition in the patients with liver cirrhosis. The imbalance of t-PA and PAI was not a main cause of hyperfibrinolysis in the patients with liver cirrhosis.


A special high speed photography apparatus which is composed of Trigger Device,Delay Timer,and ultra-rapid flasher was designed and tested experimentally.


In the framework of a research project funded by the European Commission, innovative construction systems for load and non-load-bearing reinforced masonry walls are being developed. In particular, a new reinforced masonry system made with perforated clay units, purposely developed for low-rise residential buildings to withstand in-plane actions, based on the use of horizontally perforated clay units and concentrated vertical reinforcement, is under study for the application in areas characterized by low to high seismic hazard. This contribution presents the description of this construction system and the first experimental results obtained.


Strategic technology planning sets the course for the future production of a manufacturer. Therefore, paying attention to market trends and new emerging technologies is indispensable. In order to compare different technologies from a longterm perspective, this paper presents an approach for the strategic selection of manufacturing technologies. Thereby, a multi-criteria evaluation is employed to incorporate the strategy of a producing company and consider quantitative and qualitative influencing factors. Because most factors are uncertain and the result of expert estimations, the approach includes the consideration of intrinsic uncertainties.


portion of the book is devoted to the authors' views with respect to efficient collective bargaining and the maintenance of smooth industrial relations. Possible pitfalls, advisable procedures, and sound practices are pointed out, especially in the chapters on the &dquo;art of collective bargaining,&dquo; management strategy in contract negotiation, grievance procedure, and administration of union contracts.


The invention discloses an ultrahigh speed real-time three-dimensional measuring device and an ultrahigh speed real-time three-dimensional measuring method. The measuring device comprises a matrix camera, and one or more laser displacement sensors; and the measuring method comprises the following steps: obtaining a three-dimensional datum point and a spacial linear equation by the laser displacement sensors, the matrix camera and a planar pattern; and on the basis of the obtained datum point and spacial linear equation, according to measured displacement of a measured object, calculating coordinates of measured light spots of the measured object positioned at different positions in global coordinates so as to complete the ultrahigh speed real-time three-dimensional vision measurement on the measured object.


People have been utilizing Voice over Internet Protocol (VoIP) in most of the conventional communication facilities which has been of assistance in the enormous attenuation of operating costs, as well as the promotion of next- generation communication services-based IP. As an intimidating upshot, cyber criminals have correspondingly started interjecting the environment and creating new challenges for the law enforcement system in any Country. This paper presents an idea of a framework for the forensic analysis of the VoIP traffic over the network. This forensic activity includes spotting and scrutinizing the network patterns of VoIP-SIP stream, which is used to initiate a session for the communication, and regenerate the content from VoIP-RTP stream, which is employed to convey the data. Proposed network forensic investigation framework also accentuates on developing an efficient packet restructuring algorithm for tracing the depraved users involved in a conversation. Network forensics is the basis of proposed work, and performs packet level surveillance of VoIP followed by reconstruction of original malicious content or network session between users for their prosecution in the court.


This column is devoted to the summary of research and evaluation articles on telehomecare. Telehomecare encompasses a number of different modes ranging from communication with providers through the Internet to the use of different apparatus at home for measuring patient vital signs to videoconferencing. These strategies have the potential to increase access to services, thereby improving quality of care and health outcomes. They have the potential to improve preventive care and early intervention while decreasing more costly emergency care.Despite the potential benefits, telehomecare has not been widely implemented. The following summaries provide details on some of the successes and challenges in the implementation of telehealth programs. For additional details about the interventions and studies described, we suggest that our readers go to the original articles.


Abstract With the rapid development of the Internet, more attention has been paid to information security and copyright issues in the network, and people's copyright awareness has gradually been set up. Based on signal processing and image processing, I have studied embedding digital watermark into DCT domain. Through people's copyright awareness has gradually been set up. The maintenance of copyright has become a hot topic, and the development of digital watermarking has solved this problem for people [1]. Thus, watermarks are embedded in color images. Before I add watermark data, I scramble the watermark data. By contrast, the watermark algorithm embedded in the DC component of the RBG model is robust. Based on signal processing and image processing, I have studied embedding digital watermark into DCT domain. Through people's copyright awareness has gradually been set up. The maintenance of copyright has become a hot topic, and the development of digital watermarking has solved this problem for people.. Thus, watermarks are embedded in color images. Before I add watermark data, I scramble the watermark data. By contrast, the watermark algorithm embedded in the DC component of the RBG model is robust.


In this paper, a new approach of interpreting Egyptian Dramatic Ramesseumpapyrus 45, Scene 12, is undertaken. In the concrete case a new explanation for ś in is put forward. The old view of K. Sethe, who translates the whole passage as 'to kill goose' or ś alone with 'to strangulate goose', is questioned. The new proposal tries to prove that ś can be a defective writing for ś ṯt 'pluck' or ṯśi 'bind', respectively. The exchange between ś and dentals may have played a vital role.


This article examines how the novel El cojo bueno (1996) by Guatemalan writer Rodrigo Rey Rosa posits an ethics that reconstellates the motifs and assumptions that have informed the revolutionary and transition-to-peace efforts of Central America. Through a careful reading of the text, I demonstrate how the novel pushes against the limits of the neoliberal 'culture of peace' and gives expression to an ethics that is attuned to the complex sociopolitical conditions of the postwar period. More specifically, I show how the novel develops a moral vision that registers but also resists the impunity, violence, and social disaffection that have devastated the region. The novel dramatizes what the moral life has come to mean in postwar Central America, namely, that it is a matter of grappling with the antinomies of freedom and unfreedom, of compassion and cold survivalism, and refusing to rest easy with either option. Ultimately, El cojo bueno marks a key moment when a new conception of ethics begins to take shape in postwar Central American literature.


Jyri Hanski Supporting strategic asset management in complex and uncertain decision contexts Lappeenranta 2019 97 pages Acta Universitatis Lappeenrantaensis 863 Diss. Lappeenranta-Lahti University of Technology LUT ISBN 978-952-335-396-1, ISBN 978-952-335-397-8 (PDF), ISSN-L 1456-4491, ISSN 1456-4491 Strategic asset management can be defined as strategic-level coordinated activity of an organization to realize value from assets. Strategic asset management decisions are often uncertain and complex. Uncertainty refers to the state of deficiency of information related to an event, its consequences, or its likelihood. Complex systems have a history, are evolving and involve large numbers of interacting elements, where minor changes may have major consequences. The complexity and uncertainty of strategic asset management stems from factors such as long lifetimes of assets, imperfect information on which the decisions are based, multiple stakeholders with possibly conflicting needs and requirements, various system hierarchical levels, complex technologies, information systems and organizational structures, and varying asset types and life cycles. In addition, strategic asset management is influenced by many emerging trends and perspectives such as regulation and legislation, sustainability, circular economy and climate change, enabling technologies, ecosystem, business models, risk management, robustness and flexibility, and life cycle information management. To manage the uncertainty and complexity related to strategic asset management, there is a need for methods supporting strategic asset management in complex and uncertain decision contexts. The main research question of this dissertation is "how to manage assets in complex and uncertain decision contexts with strategic decision support methods". To answer this question, the research provides a holistic view of the emerging trends and perspectives affecting strategic asset management. Furthermore, existing methods are identified and classified, and novel methods are developed and tested for supporting strategic asset management under complex and uncertain decision contexts. The key concepts related to asset management, emerging trends and perspectives, and existing decision support methods are explored. Three novel methods are developed and tested using design science research as a research strategy. Qualitative data collection and analysis methods are utilized. The main contributions of this dissertation are: 1) a novel classification of emerging trends and perspectives in strategic asset management 2) advancing the classification of methods supporting strategic asset management in complex and uncertain decision contexts, and 3) developing and testing novel methods for supporting asset management decisions in complex and uncertain decision contexts.


The results of genital reconstructive operations in 84 females with ambiguous genitalia due to congenital adrenal hyperplasia are presented. Most patients required both clitorectomy and vaginal exteriorization. Urinary tract infections and postoperative vaginal stenosis were the complications encountered most frequently. Long-term results of the initial operation were satisfactory in approximately 80% of the patients; except for newborns, the likelihood of success at operation seems less related to the patient's age at the initial procedure or the degree of genital deformity than to positive preoperative identification of the vagina.


Intraventricular hemorrhage (IVH) is the most common form of cerebral hemorrhage in preterm infants, affecting ∼15–20% (1). Despite accurate postnatal monitoring, IVH is difficult to diagnose during the first 72 h after birth because at this stage, clinical symptoms and radiologic assessment of brain damage may still be silent (2). The availability in these patients of quantitative indicators suggesting subclinical lesions at a time when the monitoring indicators are unable to detect bleeding is therefore important. Furthermore, quantification of the extent of the hemorrhaged lesion could permit the prevention and/or treatment of clinical neurologic damage.

S100B is an acidic calcium-binding protein found in the nervous system, where it is concentrated in glial cells (3). The presence of increased S100B in the blood and cerebrospinal fluid (CSF) is a consolidated marker of brain damage in adults and children (4)(5)(6)(7)(8) and has been proposed recently for use in preterm newborns developing IVH (9). We have detected the S100B protein in the urine of preterm newborns under normal conditions and established reference values for the protein at the first urination (10). The present work, extending from the earlier study, investigates urine S100B in preterm newborns developing IVH to offer an indicator for the early detection of IVH.

We performed a case-control study on 18 preterm newborns (29–35 weeks of gestation) with IVH in whom urine S100B was measured at first urination (time 0) and at 24 (time 1), 48 (time 2), and 72 h of age (time 3). IVH was diagnosed at 72 h after birth by ultrasound scanning (11): eight infants were classified as grade II (IVH without ventricular dilatation); eight as grade III (IVH with ventricular dilatation); and two as grade IV (IVH with parenchymal lesion). No other ultrasound abnormalities were described at …


Schönhage-Strassen's algorithm is one of the best known algorithms for multiplying large integers. Implementing it ef?ciently is of utmost importance, since many other algorithms rely on it as a subroutine. We present here an improved implementation, based on the one distributed within the GMP library. The following ideas and techniques were used or tried: faster arithmetic modulo 2n + 1, improved cache locality, Mersenne transforms, Chinese Remainder Reconstruction, the √2 trick, Harley's and Granlund's tricks, improved tuning.


About half of the cases with chronic insomnia are related to psychiatric conditions., the remaining cases include insomnia related to medical conditions and sleep disorders. Insomnia not attributable to other disorder is termed primary insomnia. Sleep hygiene, and treatment of any underlying condition are the initial therapeutic approaches of insomnia. Benzodiazepine and non-benzodiazepine hypnotics promote sleep through a similar effect on benzodiazepine receptors which enhance GABA activity. The principal differences among those hypnotics relate to the duration of action. The risks of tolerance, abuse, and dependency are much less marked in non-benzodiazepine hypnotics. The use of antidepressants and other sedating drugs for treatment of insomnia is common. Behavioral treatment of insomnia can be quite effective. A number of approaches such as relaxation therapy, stimulus control, sleep restriction and cognitive therapy have proven to be effective. Combined or sequential pharmacologic and behavioral are often effective.


Bird is fauna that can be found from low land up to the upland. The widespread has made birds as potencial  natural wealth source of Indonesia. Sulawesi is an area which has a large number of endemic species, and the most various one in Wallacea area.  Besides its role as an ecosystem balance, bird is also an indicator of environmental change. The forest area of Namo village was one of the bird habitats of primary foreSigi District. The objective of the research was to find out the spread pattern of birds species in the forest of Namo village Kulawi subdistrict Sigi District. The method applied was Point Index Of Abundance (IPA-Count). The data Analysis was done by using Morisita Index (I ), the research applied random method by eight spots. The research was conducted on December 2015 up to the month of February 2016, it was locatec in forest area of namo village Kulawi Subdistrict Sigi District. Based on the result of the research it showed that there were 19 species that represented 13 families in populationof 50 individual. Morisita Index (I ) found that there were 9 species of birds with group spread pattern and only 3 species with similar spread pattern, beside that there were 7 species which spread pattern could not be analized because of individual abundance of each species within one individual. K eywords : Distribution , Birds , Forest


The reaction of excited singlet oxygen atoms with methane has been studied by photolysis of N2O–CH4 mixtures with 1849 A radiation from a low-pressure mercury lamp. The results have been explained by a mechanism involving the insertion of oxygen atoms into the C–H bonds in methane to give vibrationally excited methanol: O*+ CH4→ CH3OH*. A kinetic analysis of the results gave an order-of-magnitude estimate of k15=ca. 3 × 1010 l mol–1 s–1 at room temperature. The results obtained at high methane pressures provide evidence for the nitrous oxide-photosensitized decomposition of methane.


Wireless Sensor Networks (WSNs) are usually deployed in several specific places to observe or monitor various environmental situations. Sensors have ability to sense, transmit and retransmit (reply) their data to other neighbor nodes through the network or to the base station either directly or through multi-hop. The development of WSN applications was directed to support different activities. Limitations on their sizes, control and costs add many constraints on the network performance such as transmission range, sensing range, coverage area, lifetime, computation and memory. The sensor networks can be used and linked together depending on the mesh topology. This network is called Wireless Mesh Network (WMN). Wireless Mesh (WM) consist of mesh routers, mesh clients, and gateways. The focus in this article is how to evaluate and improve the performance of the WMN by increasing its throughput. In this article a regression model is utilized as a mathematical tool to predict and expect the number of the possible links and their lengths in each suggested network topology. Shortest paths are also estimated and evaluated for different networks.


Objective
To investigate the electrophysiological characteristics of myocardium after hypothermic ischemia-reperfusion (I/R) in rats with different degrees of arrhythmia using an in vitro experiment.

Methods
Healthy clean-grade male Sprague-Dawley rats, aged 2-3 months, weighing 300-400 g, were used in this study.The rats were sacrificed after anesthesia, and their hearts were rapidly excised.Sixteen Langendorff-perfused hearts were prepared and divided into 2 groups (n=8 each) by a random number table method: control group (group C) and hypothermic I/R group (group I/R). The hearts were made globally ischemic for 60 min followed by 30-min hypothermic (4 ℃)reperfusion to establish the model of hypothermic I/R injury.The occurrence and duration of arrhythmia and time of recovery of spontaneous heartbeat were recorded during reperfusion.The rats in group I/R were further divided into low-risk group (I/R-L group, ventricular arrhythmia score≤3 points) and high-risk group (I/R-H group, ventricular arrhythmia score>3 points) according to the arrhythmia score.Monophasic action potential amplitude (MAPA), monophasic action potential (MAP) duration at 50% and 90% repolarization (MAPD50 and MAPD90) and maximum ascending velocity (Vmax) of phase 0 in the endocardium, myocardium and epicardium of the left ventricular anterior wall were recorded at 30 min of equilibration (T0) and 15 and 30 min of reperfusion (T1, 2). The effective refractory period (ERP) and ventricular fibrillation threshold (VFT) of the left ventricle were measured by programmed electrical stimulation, and the ERP/MAPD90 ratio was calculated.

Results
Compared with the baseline at T0, MAPA in the three layers was significantly decreased, and MAPD50 and MAPD90 were prolonged at T1, 2 in I/R-L and I/R-H groups, and Vmax in the three layers was decreased at T1, 2 in I/R-H group (P<0.05). MAPD50 and MAPD90 in the three layers were significantly shorter at T2 than at T1 in I/R-L and I/R-H groups (P<0.05). Compared with group C, MAPD50, MAPD90 and ERP in the three layers were significantly prolonged at T1, 2, the ERP/MAPD90 ratio was decreased, and VFT was increased in I/R-L and I/R-H groups (P<0.05). Compared with I/R-L group, the duration of arrhythmia and MAPD90 and ERP in the three layers were significantly prolonged at T2, the ERP/MAPD90 ratio was decreased, and VFT was increased in group I/R-H (P<0.05).

Conclusion
Myocardial depolarization is inhibited, repolarization duration is prolonged, and electrophysiological stability is decreased after hypothermic I/R in the rats with arrhythmia, and the prolongation of myocardial repolarization and decrease in electrophysiological stability are more obvious in the rats at high risk of arrhythmia.

Key words:
Myocardial reperfusion injury; Hypothermia, induced; Arrhythmias, cardiac; Cardiac electrophysiology


Abstract New species and new records of the genus Anomotarus Chaudoir from Australia. 2nd supplement to the 'revisions of the species of the genus Anomotarus Chaudoir'. Three additional new species of the lebiine genus Anomotarus Chaudoir, subgenus Anomotarus, and one species of the subgenus Nototarus Chaudoir are described from Australia and Tasmania: Anomotarus (s. str.) moorei from Australian Capital Territory, A. (s. str.) kimberleyensis from far northern Western Australia, A. (s. str.) sericipennis from Tasmania, and A. (Nototarus) eyrensis from the Eyre Peninsula in south Australia. The new species are introduced in the most recent keys to the Australian species of the genus Anomotarus (s. l.). new records of some rare or recently described species of the subgenera Anomotarus s. str., Nototarus Chaudoir, and Amplitarus Baehr are communicated.


The improved screw for coupling the line connector to the spout - the whole assembly is disclosed. The present invention in various other applications that require fluid coupling or bag-may be used in the boxed-in. In one embodiment, the screw coupling can be achieved by matching the flexible tab and the internal thread of the line connector located on the spout. Deformation of tabs during screwing provides not tack to stabilize the assembly during screwing. Interaction of the structure near the deformable tabs and the screw end portion provides a self-locking of the assembly. Further, the tabs are located on the flange, and provides a compatibility of the line connector and the invention of the prior art.


Abstract
Soil crust decreases soil infiltration and prevents plant stablishment. Thus reduction of crust effects is a prominent way to avert desertification. This study was conducted to investigate the effect of polyacrylamide on emergence of Canola seedlings in a crusted soil and some physicochemical properties of soil such as pH, EC, SAR and bulk density in a field located in Date and Tropical Fruits Research Center of Ahwaz. Statistic design was RCBD with seven treatments (0, 5, 10, 15, 20, 25 and 30 kgha-1 of Polyacrylamide) wich solved in water with three replication. Similar plots with no plant were used to investigate the changes of some physicochemical properties of soil. Results indicated that all polyacrylamide treatments increase the canola seedling emergence significantly, so that seedling emergence was 3.5 times greater than control in 25 kgha-1 of polyacrylamide and had no effect on physicochemical properties of soil (except bulk density). All treatments of this polymer decreased soil bulk density in relation to control treatment significantly. Results showed that the most effective treatment of polyacrylamide was 25kgha-1.

Key words: Polyacrylamide, Crust, Canola, Physicochemical characterestics


* Accepted for publication by Leonard Carmichael of the Editorial Board and received in the Editorial Office, October 22, 1935. 1 Presented in part at the spring meetings of the New York Branch of the American Psychological Association, April, 1935, under the title "The Visual Acuity of the Cat as a Function of Discrimination Distance." Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Brown University as one part of a thesis entitled "The Mechanism of Discrimination in the Cat."


A gas leak at a residence caused an explosion. It was hypothesized that the soil shrink/swell potential caused a break in the polyethylene (PE) gas pipe-coupler connection, which subsequently resulted in a leak and an explosion. However, this claim was without any scientific reasoning or engineering principles such as soil-structure interaction. Review of prior information indicated that sometime prior to the explosion a water line was installed below the PE gas pipeline and a BOMAG multipurpose compactor was used to compact the backfill in the water pipe trench. The waterline and PE gas pipeline were perpendicular to each other. Using finite element method (FEM) analysis of the soil-pipe system and the scientific method using site-specific soil, geophysical, and geotechnical data it was shown that the break in the PE pipeline and coupler was due to deformation (displacement) of the soils in the trench area, where the PE gas service line was present and not due to soil movement alone. This deformation is the result of external and applied loads from the BOMAG compactor in the static and dynamic compaction modes. A field re-creation of the construction sequence on a later date corroborated very similar pipe displacements as that predicted by the numerical modeling. This confirmed the results from numerical modeling and confirmed that the construction activities during the installation of water service and/or sewer lines underneath the gas line caused the gas line to sag and pull out at the adjacent pipe-coupler connection.


Abstract Background Continuous infusion and bolus schedules of flavopiridol in mantle cell lymphoma (MCL) have yielded disappointing results. However, a pharmacologically derived hybrid schedule of administration is effective in refractory, genetically high-risk chronic lymphocytic leukemia (CLL), though life-threatening tumor lysis syndrome (TLS) may occur in patients with very high lymphocyte counts. Because flavopiridol decreases cyclin D1 and Mcl-1 and induces apoptosis in MCL cells, is significantly toxic for cell lines derived from the activated B-cell–like type of diffuse large B-cell lymphoma (DLBCL; OCI-Ly3), and downregulates NF-κB, we investigated the hybrid schedule in MCL and DLBCL. Patients and Methods Flavopiridol was administered as a 30-minute bolus (mg/m 2 ) followed by a 4-hour continuous infusion (mg/m 2 ), weekly for 4 doses every 6 weeks. Separate escalation rules applied to cycle 1 week 1 (C1W1) and all other weeks of treatment. Dose levels on C1W1 were DL1: 25/25 (4 patients), DL2: 30/30 (10 patients), and DL3: 30/50 (6 patients). Dose escalation on subsequent weeks was not possible due to toxicity, and all patients received 30/50. All patients received TLS prophylaxis. Paired biopsy samples obtained before and after the first dose were analyzed for CDK targets. Results Patient (n = 20) characteristics: median age, 59 years (range, 24-80 years); male, 15 (75%); median prior regimens, 2 (range, 1-6). Ten patients had MCL, and 10 had DLBCL. Responses included partial response (PR) in 2 patients (1 MCL; 1 DLBCL; 10%), stable disease (SD) in 5 patients (25%), and progressive disease (PD) in 13 patients (65%). Dose-limiting toxicities (DLTs) included TLS and severe vomiting/diarrhea in 2 patients at DL3. The maximum tolerated dose (MTD) and phase II dose have not yet been defined. Other toxicities were grade 4 absolute neutrophil count (ANC; 10 patients) requiring prophylactic granulocyte colony-stimulating factor (G-CSF), TLS (1 patient), and bowel perforation (1 patient). Decreased Rb staining at the S807/811 phospho-site was noted in 8 of 9 paired samples analyzed (range, 20%-75%; P = .027) and at the S780 site in 7 of 8 paired samples (range, 38%-91%; P = .00016), suggestive of G1 CDK inhibition. In 1 sample in which p53 was detected, there was an increase post-treatment, suggestive of CDK9 inhibition. Conclusion The hybrid schedule of flavopiridol has modest activity in relapsed MCL and DLBCL. TLS occurred infrequently and was reversible. DLTs were TLS and gastrointestinal toxicity. Accrual continues. Analysis of cell cycle and transcriptional CDK targets is ongoing.