e22500 Background: Oncologists are change agents to improve tobacco cessation among patients. As part of the National Cancer Institute Cancer Center Cessation Initiative, we established an electronic health record (EHR, Epic)-based "opt-out" approach to refer patients to tobacco treatment specialist without active involvement by oncologists. However, the role of oncologists in contributing to the "opt-out" approach to patients has not been explored. We tested the hypothesis that a multi-component educational program for oncologists would increase the proportion of patients who completed tobacco treatment appointments. Methods: As a quality improvement initiative, oncology providers at the Rochester Mayo Clinic Cancer Center were educated using a multimodal academic detailing approach with group and individual educational sessions. Its effectiveness was tested using a modified step-wedge implementation design. The primary outcomes were patient behaviors that could plausibly be changed by conversations with their provider: the rate at which cancer patients identified as current tobacco users scheduled an appointment in the Nicotine Dependence Center (NDC) (which required active patient involvement), and the rate at which patients scheduled for a NDC appointment completed their appointment. Comparisons were made before, during, and after the education period (from July through Dec 2019) and with a separate group of providers who did not complete education (results examined over a similar time period). Results: Education did not improve outcomes in providers who received education; indeed, the rate of appointment scheduling decreased, although this may reflect other concurrent changes in the referral process (Table). Outcomes were similar between providers who did and did not receive education. Conclusions: Tobacco cessation efforts should be routinely integrated into cancer care to improve outcomes. The "opt-out" program resulted in approximately 1 in 5 cancer patients being seen for tobacco use, but an academic detailing approach designed to equip oncology providers to encourage their patients to complete appointments was not effective. Other approaches are needed to increase the uptake of tobacco treatment in these patients. [Table: see text]


PURPOSE: To reduce a loss of an internal space and to reduce the cost by using a common-use output-side case and by using a group of input-side cases including a first and a second input-side case whose front and rear lengths are varied. CONSTITUTION: On a front wall 21, an output-side case 2 is installed which has a cylindrical section 22 which extends backwards from the front wall 21 and which is installed on the front wall 21 into one body with the front wall 21. On a rear wall, a group of input-side cases 3 including a first input side case and a second input-side case 5 is installed. In the output-side case 2, an output-shaft output-side bearing seating and at least two intermediate-shaft output side bearing seatings 11A, 12A are installed. The first input-side case has an input-shaft bearing seating 9A and one or more intermediate-shaft input- side bearing seatings 12B for supporting intermediate shafts 11, 12 at the input side. Meanwhile, the second input-side case 5 has the input-shaft bearing seating 9A and has the larger number of intermediate-shaft input-side bearing seatings 12B than the first case. By this, a productivity is increased and the size is reduced. COPYRIGHT: (C)1993,JPO&Japio


For each pair of integers g ≥ 2 and h ≥ 1, we explicitly construct infinitely many fiber sum and section sum indecomposable genus g surface bundles over genus h surfaces whose total spaces are pairwise homotopy inequivalent.


Tracheostomy is indicated for very‐low‐birth‐weight infants (VLBWIs) with prolonged respiratory problems during the perinatal period. The objective of this study is to clarify the epidemiology and risk factors in VLBWIs with tracheostomy after birth in Japan.


The present study was undertaken to record the winter bird species diversity from Gandheswari River bank of Bankura District of West Bengal, India with an eye to anthropogenic interventions that have altered the natural habitat to influence the avian diversity. In a modified point count method a total of 105 different bird species were identified from the present study location during the winter months (October – March) of two consecutive years 2011 – 2012 and 2012 – 2013 respectively. Among all the bird species recorded 20 were winter migrants while one was passage migrant and the rest were resident in nature. Anthropogenic interventions were observed to exert an overall negative influence on avian diversity from the present study location.


The ENVISAT satellite with its many sensors opens for new, interesting approaches of combined multi-sensor, multi-temporal monitoring. In this study, we have focused on monitoring of snow parameters in the snowmelt seasons of 2003 and 2004 (April-June) in South Norway. The sensors used in this study are ENVISAT MERIS and ASAR and Terra MODIS. The study is motivated by operational prospects for snow hydrology, meteorology and climate monitoring. We have developed a generic multi-sensor/multitemporal approach for monitoring of snow cover area (SCA), snow surface wetness (SSW) and snowmelt onset time (SOT). The objective is to analyse, on a daily basis, a time series of optical and SAR data together producing sensor-independent products. We have defined raster products for each variable and developed a prototype production line. The production line automatically performs data retrieval, pre-processing, parameter retrieval, data aggregation and product generation. A few algorithms for multi-sensor/time-series processing have been developed and are compared. One approach is to analyse each image individually and combine them into a day product. How each image contributes to the day products is controlled by a pixel-by-pixel confidence value that is computed for each image analysed. The confidence algorithm is able to take into account, e.g., information about observation geometry, probability of clouds, prior information about snow state and reliability of the classification. The time series of day products are then combined into a multi-sensor/multi-temporal product. The combination of products is done on a pixelby-pixel basis and controlled by each individual pixel's confidence and a decay function of time for the product. The "multi-product" should then represent the most likely status of the monitored variable.


The purpose of this study was to create an accurate and customizable tool to be used by dairy veterinary consultants to help their clients assess the economic effects of CM during the first 30 days of lactation (DIM), in order to better guide decision making and management interventions during the transition period.


The air2water model is a simple and efficient tool for modeling surface water temperature in lakes based solely on the air temperature. In this article, we propose to modify the air2water model in such a way that different parameters would be associated with lake stratification of cold waters than with lake stratification of warm waters. The situation of a mix of both cold water and warm water is also considered. The model is tested on 22 lowland Polish lakes against two classical air2water variants. As the new air2water model variant is slightly more complicated than the basic versions, we focus on the importance of the choice of the calibration method. Each variant of the air2water model is calibrated with eight different optimization methods, which are also compared on various benchmark problems. We show that the proposed variant is superior to the classical air2water models on about 90% of tested lakes, but only if the calibration approach is properly selected, which confirms the importance of the links between the model and appropriate optimization procedures. The proposed air2water variant performs well on various lowland lakes, with exception of large but shallow ones, probably due to the weak stratification of the shallow lakes.


Objective: To study the changes of bone metabolism in the underground coal miners.Methods: Calcaneal QUS of 140 underground coal miners were measured by UBIS 3000 QUS and the concentrations of urine deoxypyridinoline(DPD)were assayed by enzyme linked immunosorbent.The same methods were used to the surface coal miners.Results:The values of calcaneal BUA,SOS and STI in the underground coal miners were significantly lower than those of the surface coal miners(P0.01).Urine DPD concentrations of underground coal miners were significantly lower than those of the surface coal miners(P0.01).Conclusion:Underground coal miners suffered abnormality in bone metabolism because of lack of sunshine,hypoxia and toxic gas.


The excitation function of H Ly-alpha from the astrophysically important dissociation of electron-excited H2 over the range 10-700 eV has been measured. The analysis predicts the cross section to energies higher than the present experimental limit, and it is found that the predicted shape is in close agreement with measured results. At 6 eV the cross section is dominated by the electric dipole first Born component, while at 100 eV the electric dipole component constitutes 73 percent of the total H(2p) cross section. The cross sections of the H(2s) and H(1s) components are calculated. 36 refs.


Extant Archaeidae, also known as pelican or assassin spiders, have an Austral distribution (South Africa, Madagascar and Australia), but were present in Eurasia during the Mesozoic and Cenozoic, as attested by fossils from Cretaceous Burmese amber (Ross A. 2019. Burmese (Myanmar) amber checklist and bibliography 2018. Palaeoentomology 2(1): 22–84) and Eocene European ambers (Wunderlich J. 2004. Fossil spiders in amber and copal: conclusions, revisions, new taxa and family diagnoses of fossil and extant taxa. Hirschberg-Leutershausen: Ed. Joerg Wunderlich, 1893 p.). They have been known to occur in Oise amber (Ypresian, early Eocene, MP7), from northern France. However, they are not abundant in Oise amber, and have been the subject of few studies until now. Here, we describe the only well-preserved, almost complete, archaeid fossil specimen. This adult male is described as Myrmecarchaea antecessor sp. nov, based on the presence of unique morphological features. The elongate petiolus and extremely long legs are characteristic of the genus Myrmecarchaea from the Middle Eocene Baltic amber. However, unique traits such as the thick, stout petiolus and the extremely elongated, posteriorly tapering cephalothorax distinguish it from the other species of Myrmecarchaea. This specimen is of high interest, as besides being a new species, it is also the first documented adult male in the genus, allowing us to observe sexual characters for the first time. Furthermore, it is the first occurrence of this genus outside Baltic amber, showing affinities between Oise and Baltic ambers, which are, otherwise, very different in their faunistic compositions, and further extends the known past range of the archaeid spiders.


In 1989, V. Popa [17] first introduced the concept of rare continuity. In this paper, we have introduced a new class of functions termed as rarely μ -continuous functionswhich unifies different weak forms of rarely continuous functions and have investigated some of its properties.


Similarity metric and distance metric are widely used in many research areas and applications. In this paper, for a given similarity metric, we will introduce a family of distance metrics of Minkowski type. We will then show general solutions to construct normalized similarity metric and normalized distance metric from a similarity metric and a distance metric. Applying the general solutions to a given non-negative similarity metric and its induced family of distance metrics, we derive general normalized similarity metrics and normalized distance metrics. Finally we briefly discuss some of the applications of our general similarity and distance metric formulations.


This study uses survival analysis to estimate the lifetime of Swedish asphalt paved roads. The roads were separated by binder type, such as unmodified bitumen and polymer-modified bitumen (PMB). Road pavements with PMB were compared to equivalent roads with regard to annual average daily traffic, heavy vehicles, road type, road width, speed limit, construction year, region, bearing capacity, pavement type, stone size, and rut bottom distance. The analysis was based on almost 500,000 records of pavement maintenance and road condition measurements from the Swedish Transport Administration's Pavement Management System database, dating back as far as the 1970s. The results showed that PMB in the surface layer was expected to extend road lifetimes by 15% compared with bitumen. PMB in the underlying layer gave an 8% increase in life expectancy compared with unmodified bitumen. PMB in both layers gave a 24% increase in expected road lifetime compared with unmodified bitumen in both layers.


Dear Sir, The ABO blood group system, discovered more than a century ago, still often raises uncertainty among immunohaematologists during subtyping or detection of weak variants. A 1 and A 2 are the major subgroups of blood group A which are differentiated on the basis of reactivity of A 1 cells but not A 2 cells with anti-A 1 lectin (Dolichos biflorus). Routine subgrouping of all A and AB blood groups in India is limited to a few blood centres because of economic constraints and this subgrouping is usually performed only when there is a group discrepancy, a problem during compatibility testing or a history of a transfusion reaction. The role of subtyping group A is, however, critically important when it is being done for (A 2 -O) incompatible organ transplantation. There are a few studies on weak subgroups of the ABO system but the prevalence and occurrence of the "A-intermediate" (A int ) subgroup in India are underreported and have not been published in recent decades. We report here the case of A int subgroup encountered in two siblings during the pre-transplant work-up of an incompatible live donor liver transplant. A 34-year old female patient, resident in Kerala, was admitted to the Liver Transplant and Hepato-Biliary Department with features of acute on chronic liver disease due to Wilson's disease; a liver transplant was planned. Samples from the patient and two siblings were subjected to urgent blood grouping and subtyping in the Immunohaematology Laboratory of our Blood Bank. During blood grouping, forward grouping was done using gel technology (Diaclon, Diamed ID, Switzerland) while reverse grouping was performed using in-house prepared pooled A, B and O cells. All the laboratory techniques were carried out according to the manufacturer's instructions. Blood groups were interpreted based on the agglutination pattern with forward and reverse grouping. The recipient's blood group was O-positive and both siblings were A-positive. Considering the possibility of incompatible (A 2 -O) liver transplantation, the siblings were further subtyped using anti-A 1 lectin (Diamed AG, Cressier sur Morat, Switzerland) to classify them into A 1 or A 2 . Using a tube method with A 1 lectin, both siblings showed 12+ positive agglutination. A provisional report of A 1 subtype was given to both siblings. Due to the weak reaction with A 1 lectin, the sample was further tested by H lectin (Tulip Diagnostics, Goa, India) which gave a strong 4+ reaction favouring towards an A 2 subtype. Bearing in mind the possibility of false positive results, we checked the potency and specificity of the A 1 and H lectins using control A 1 , A 2 and O cells. The titres of A 1 lectin and H lectin were 1:16 with standard A 1 and O cells, respectively. Saliva inhibition studies performed on both the siblings showed the presence of A and H substances. The blood groups of both siblings were reported as A int and the previous reports of A 1 subtype were withdrawn. As the antigenicity of this subgroup was likely to be higher than that of A 2 , both the siblings were cancelled from the potential liver donor list. Blood samples from the patient's parents were also tested, given the possibility of A int in other family members. In this family, the parents' blood groups were A 1 and O group; A int was present only in the two siblings. A 1 and A 2 differ from each other both qualitatively and quantitatively, with A 1 cells carrying 8.1 to 11.7×10 antigenic sites as compared to 2.4 to 2.9×10 sites on A 2 red blood cells. The prevalences of A 1 , A 2 and weak subgroups in South India were recently reported to be 98.4%, 1.85% and 0.01%, respectively. There are reports of safe and successful liver transplants from A 2 blood group donors to O blood group recipients, without plasmapheresis or rejection. The role of subtyping the A blood group has gained importance since the beginning of ABO incompatible organ transplantation. There are, however, cases reports of accelerated acute rejection of A 2 renal allografts in O recipients which might have resulted from misapplication of the results of standard lectin agglutination to the transplant setting, highlighting the importance of subtyping the A group. More sophisticated methods of ABO phenotyping, such as erythrocyte flow cytometric analysis, have been suggested in the transplant setting. The existence of an additional subtype of A, which exhibited characteristics intermediate between A 1 and A 2 (A int ), was first recognised by Landsteiner and Levine. While Brain's classification was based on weaker reactions (+ or ++) with Dolichos, with H (Ulex) reactivity stronger than A 2 , the "A int " designated by


6‐Hydroxydopamine and its corresponding ortho‐ and para‐quinones were injected intraperitoneally into male Swiss‐Webster mice. Measurements made 72 h after injection showed that all three compounds caused a decrease in the uptake of [3H]norepinephrine into slices of mouse heart tissue in vitro, a decrease in the endogenous content of heart norepine‐phrine, and a disappearance of the adrenergic nerve plexus of the mouse iris as viewed by fluorescence histochemistry. These data suggest that both the ortho‐ and para‐quinones of 6‐hydroxydopamine are capable of producing a chemical sympathectomy similar to that caused by 6‐hydroxydopamine.


The article was aimed to conclude and analysis several common methods of Data Mining in the research of TCM,because we often need to face up to the questiones of data analysis and the basic analysis methods can hardly catch up with the development of science.It will be very helpful for us to grasp the ideas and methods of Data Mining which will probably do good to the TCM research.


Load imbalance among multi-cell has tremendous impact on the network performance. The previous researches on load balancing place focus on maximizing the load balancing index of the network and cannot always guarantee the best performance of network's key performance indicators (KPIs). In this paper, taking both the network resource limitation and users' data rate demand into account, we aim to simultaneously optimize both the load balancing index and network average load for quality-of-service (QoS) requirements services, while maximizing the network utility for other services. Moreover, we proposed a practical algorithm with low complexity. Comparing with the previous methods, simulation results show that the proposed method can achieve better network performances, such as lower new call blocking rate and higher network resource utilization. Index Terms—LTE, multi-cell, load balancing (LB), quality-of- service (QoS), multi-objective optimization problem


This paper deals with the stress singularity induced at the interface corner between the viscoelastic thin film and the elastic substrate as the film absorbs moisture from the ambient environment. The thin film is assumed to be a linear viscoelastic material and moisture effects are assumed to be analogous to thermal effects. The time-domain boundary element method is employed to investigate the behavior of interface stresses. The order of the singularity is obtained numerically for a given viscoelastic model. The numerical results exhibit the relaxation of interface stresses and large stress gradients are observed in the vicinity of the free surface. It is shown that the stress singularity factor is relaxed with time, while the order of the singularity increases with time for the viscoelastic model considered. Introduction Polymeric films such as polyimide are extensively used in electronic industry as dielectric insulating layers. Thin films deposited on a substrate absorb moisture from the ambient environment, which induces swelling strains into films. Polyimide films are extremely hygroscopic and absorb large quantities of water. In the presence of water, adhesion of polyimide to substrates such as glass and aluminum tends to fall off rapidly. It is well known that the interface of bonded quarter planes suffers from a stress system in the vicinity of the free surface under the external loading [1,2]. In such a region two interacting free surface effects occur, and singular interface stresses can be produced. Polymeric films in general exhibit time and moisture(or temperature)dependent properties and a time dependent stress analysis of the bi-material system is essential in understanding and predicting failure in such systems. The focus of this paper is to study the time dependent process of interface singular stresses developed in a viscoelastic thin film due to moisture sorption. The viscoelastic interface problems have been studied by several investigators. Weitsman[3] analyzed the mechanical behavior of an epoxy adhesive layer as the adhesive absorbs moisture from the ambient environment. Delale and Erdogan[4] presented the viscoelastic behavior of an adhesively bonded lap joint. Lee[5,6] performed the boundary element analysis of the stress singularity for the viscoelastic layer under transverse tensile strain. Because the order of the singularity is material-dependent, it tends to change with time in viscoelastic materials. In this study, the stress singularity at the interface corner between an elastic substrate and a viscoelastic film subjected to a uniform moisture ingression is investigated. The boundary element method(BEM) is employed to investigate the interface stresses in the viscoelastic thin film. Numerical results show that there is competition between the relaxation of the stress singularity factor and the increase of the order of the singularity. The Stress Singularity The order of the stress singularity at the interface corner between the substrate and the viscoelastic film can be determined using a method similar to that described in Ref.[2]. The substrate is assumed to be linear elastic. Fig.1 shows the region near the interface corner between perfectly bonded Key Engineering Materials Online: 2004-08-15 ISSN: 1662-9795, Vols. 270-273, pp 843-848 doi:10.4028/www.scientific.net/KEM.270-273.843 © 2004 Trans Tech Publications Ltd, Switzerland All rights reserved. No part of contents of this paper may be reproduced or transmitted in any form or by any means without the written permission of Trans Tech Publications Ltd, www.scientific.net. (Semanticscholar.org-13/03/20,17:38:00) Title of Publication (to be inserted by the publisher) viscoelastic and rigid quarter planes. The free surfaces are assumed to be traction-free and the ingression of moisture provides the only loading. Polyimide films used in electronic packages are extremely thin, with the thickness rarely exceeding m 50μ . For sufficiently thin film it is possible to neglect the moisture gradient through the thickness and consider the transient case of uniform moisture content ) t ( m ) t , ( m = x . It is further assumed that the film instantaneously acquires the saturation value at ambient humidity level, which can be expressed in terms of Heaviside unit step function as ) t ( H ) t ( m m∞ = . Here m∞ represents equilibrium moisture uptake. This simple moisture field is considered in order to allow the study to focus on the effects of viscoelastic behavior on the singular stress field. To simplify the problem, moisture effects are assumed to be analogous to thermal effects. In the following, a condition of plane strain is considered. A solution of 0 ) ; , ( 4 = ∇ t r θ φ (1) or, equivalently, 0 ) ; , ( 4 = ∇ ξ θ φ r (2) is to be found such that the normal stress, σ θθ , and shear stress, τ θ r ,vanish along 2 π θ = , further that the displacements are zero across the common interface line 0 = θ . In Eq. 2 , ξ is the reduced time defined as follows: ( ) λ λ χ ξ ξ d m t t m ) ( ) ( 0 ∫ = = (3) where χ m is the shift function, a function of moisture cycle. Under the constant moisture change ) t ( mH ∆ , the reduced time ξ of Eq. 3 becomes t m χ ξ = (4) The solution of this problem can be facilitated by the Laplace transform. With constant uniform moisture change ) t ( mH ∆ in the film, it is convenient to use the Laplace transform with respect to reduced time ξ , instead of real time t . Then, Eq. 2 can be rewritten as follows: 0 ) ; , ( * 4 = ∇ p r θ φ (5) where * φ denotes the Laplace transform of φ with respect to ξ and p is the transform parameter. Using a method similar to that described in Ref.[2], the transformed characteristic equation is obtained as follows: r θ Free Surface viscoelastic thin film elastic substrate Fig. 1. Region near interface corner between the viscoelastic film and the elastic substrate.       + −       − ) 1 ( ) ( 2 cos )) ( ) ( ( 2 1 2 2 1 2


A case of Bacteroides fragilis arthritis of the knee following intraarticular steroid therapy is described. Details of a literature review revealing 47 cases of arthritis due to nonsporeforming anaerobic bacteria are presented also. Features which, when present, suggest the possibility of anaerobic joint infection include foul-smelling pus, gas in a joint, and the unique morphology of many anaerobes on gram stain of pus. The sternoclavicular and sacroiliac joints are peculiarly susceptible to Bacteroides infections.


We present new results obtained from ESR experiments in the paramagnetic and magnetic ordered states of both crystallographic phases of the magnetic semiconductor GaCr4S8. We observe a critical behaviour typical of magnetic phase transitions, resulting in a shift and a broadening of the resonance line as well as a distortion of its shape. These features are discussed and related to the presence of magnetization fluctuations. J. Physique - LETTRES 44 (1983) L-393 - L-401


Objective: The aim of the study was to identify if arterial stiffness is influenced by the variability of 24 hour blood pressure. Design and method: 365 consecutive subjects (50.9% male) aged 47.51 ± 22.81 years were included in the study. Subjects were never treated before for hypertension. All subjects underwent 24 h-ABPM on a usual working day. Pulse wave velocity (PWV) was measured after 15 minutes of rest in the supine position. The subject was not speaking or sleeping in a quiet, semi-darkened, temperature-controlled laboratory. Participants had been advised to refrain from eating, smoking and drinking caffeine beverages and alcohol before measurement. PWV was calculated as the transit time of the arterial pulse along the carotid-femoral distance divided with the distance measured directly and modified according the guidelines. Results: The 24 h variability of systolic BP (24 h SD-SBP) was found 14.19 ± 3.76 mmHg, the 24 h variability of diastolic BP (24 h SD-DBP) was found 10.94 ± 2.30 mmHg and the 24 h variability of heart rate (24 h SD-HR) was found 10.26 ± 3.70. Carotid-femoral PWV was 8.98 ± 3.31m/sec. In the univariate analysis, carotid-femoral PWV was correlated with age, gender, hip measurement, 24 h average of SBP, 24 h average of DBP, LDL levels, e-GFR, 24 h SD-SBP, 24 h SD-DBP and 24 h SD-HR (p < 0.05 for all). However, in the multiple linear regression model, only age, e-GFR, 24 h average of SBP, 24 h average of DBP, 24 h SD-SBP and 24 h SD-DBP (p < 0.05 for all) remained significant predictors of carotid-femoral PWV, even after adjustment for other factors. Conclusions: The variability of systolic and diastolic 24 h blood pressure is an independent predictor of arterial stiffness, suggesting a role for increased variability in the pathophysiology of large arteries arteriosclerosis independent of age, gender, hip measurement, LDL levels, blood pressure levels recorded with the 24h-ABPM and kidney function.


Background: The prognosis of patients with T-cell large granular lymphocyte (LGL) leukemia is diverse, with some patients experiencing rapid progression of the disease while others surviving decades. Despite multiple case reports and a number of case series reported in literature, prognostic factors in this leukemia are unknown and no staging/prognostic system has been developed. Aim: To identify factors predicting the prognosis of patients with newly diagnosed T-cell LGL leukemia. Methods: We reviewed the presentation, laboratory data and the clinical course of patients with newly diagnosed T-cell LGL at seen at the Mayo Clinic, Rochester. T-cell LGL was diagnosed in patients with at least 2 of these criteria: morphological evidence of LGL leukemia on bone marrow biopsy or blood smear; LGL immunophenotype; evidence of clonal T-cell receptor gene rearrangements. Results: 286 patients seen at Mayo Clinic Rochester between 6/1986 and 5/2005 met diagnostic criteria (52% male, median age at presentation 64 years (range 27–88)). Lymphadenopathy, splenomegaly, and hepatomegaly were present in 9%, 4% and 1.5% of the patients respectively. Median hemoglobin was 11.7 g/dL (range 3.5 – 17.1). Median absolute neutrophil count (ANC) was 1.51 × 109/L (range 0.0 – 20 × 109/L) and median absolute lymphocyte count (ALC) was 2.2 × 109/L (range 0.1 – 24). Median LGL count on peripheral smear was 0.81 × 109/L (range 0.06–10.8 × 109/L). Cytogenetic studies were done for 122 patients, of which, only 9 were abnormal. 87 patients (29%) had associated autoimmune conditions: rheumatoid arthritis (n=29), Felty's syndrome (n=11), other connective tissue disorders (n=9)). Pure red cell aplasia, aplastic anemia, idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia were seen in 17, 5, 8, 1 patients respectively. Median follow up was 50 months (range 1–229) and estimated median survival was 74.3 months. In multivariate analysis, the only independent risk factors were: anemia (hemoglobin Conclusion: The prognosis of patients with newly diagnosed T-cell LGL is variable. The presence of anemia, severe neutropenia and lymphopenia are independent poor prognostic factors in T-cell LGL. Combining these factors allows the identification of patients at a high risk of death from the disease. Further studies are needed to prospectively validate these findings and establish if the high risk group would benefit from aggressive therapy.