This Project aims a social and productive integration of the women living in the traditional community of Monteiro District based on the retrieval and revitalization of sheep wool traditional techniques handling. Brazil colonization commencement place, historical Serra da Mantiqueira range was explored in multiple ways, and its consequence was native forests degradation and impoverishment of folk traditional knowledge. Shepherd husbandry reintroduction in this region associated to teaching shared with the School of Design from PUC-Rio allows to recognize, valorize and stimulate wool spinnery and dyeing artisan techniques for textile production. Here we'll show how the partnership between the community and PUC-Rio Design School is strengthening the local social-environmental retrieval boarded on sustainable development instruments.


This paper presents a novel phonocardiogram (PCG) signal compression method based on Wavelet transform. The proposed compression method uses energy based thresholding for retaining significant coefficients, uniform scalar zero zone quantizer (USZZQ) for quantizing the amplitudes of the significant coefficients and differencing coder for integer significance map (ISM). This method is tested using the PCG records taken from qdheart and eGeneralMedical databases. The performance of the compression method is assessed in terms of compression ratio (CR), percentage root mean square difference (PRD), Wavelet energy based diagnostic distortion (WEDD) measure and mean opinion score (MOS). The compression method is evaluated with PCG signals of more than 100 records with normal sounds, murmurs, stenosis, noise and other pathologies. High compression ratios with lower distortions are achieved with the proposed method.


Rat pituitary tissue was incubated in vitro and the release of ACTH was monitored by radioimmunoassay. The release of ACTH that occurred spontaneously from unstimulated tissue was uninfluenced by a 3-hr preincubation of the tissue in the absence of calcium. ACTH release stimulated by crude hypothalamic extracts, synthetic vasopressin, dibutyryl adenosine 3',5'- monophosphate (cyclic AMP) and theophylline was inhibited by incubating pituitary tissue in the absence of calcium. It is concluded that in vitro activation of ACTH release, but not spontaneous ACTH release, is a calcium-dependent phenomenon. If ACTH release is mediated by cyclic AMP, then calcium ion is required for the action of cyclic AMP and need not oppose its formation. (Endocrinology 87:426,1970


This work presents the relevance of the researches associated with the severity of gestosis (pre-eclampsia) in the pregnant women. The importance of the violation of the mechanisms of adaptation (the predominance of catatoxic adaptation programs above syntoxic) and the principles of formation of placental insufficiency are demonstrated. The number of specific pregnancy proteins, leading to insufficient activation of adaptation programs is reduced and activity of adrenal-reactive structures is increased. The purpose was to study psycho-neural and immunologic mechanisms of formation of pre-eclampsia. The authors carried laboratory and instrumental examination of 100 women of fertile age (80 with pre-eclampsia; 20 without pathology of pregnancy, which were the control group). Personal and reactive anxiety were examined and applied the techniques of catatimic experiences of images and etc. using imaginations by method of Ericksonian hypnosis. The indicators of systems coagulation-anticoagulative, oxidant and antioxidant activity, immune-suppression and immune-activation, sympathetic and parasympathetic systems were studied in detail. The significance of the decrease in the production of specific pregnancy proteins in the development of placental insufficiency, and catatoxic adaptation programs in the pre-eclampsia is proved. The authors established the importance of study psycho-neural and immunologic correlations, corresponding to the dynamics of adaptation programs.


Correction for 'Epitaxial growth of β-Ga2O3 (−201) thin film on four-fold symmetry CeO2 (001) substrate for heterogeneous integrations' by Xiao Tang et al., J. Mater. Chem. C, 2021, 9, 15868–15876, DOI: 10.1039/D1TC02852A.


Disagreements in cytologic interpretation can have several causes, including differences in diagnostic threshold and diagnostic accuracy. These can be distinguished by a combination of statistical analyses.


In 20th century's Chinese literature,the elegant literature once became an important constituent of populace energetic and cultural life because it deeply influenced the society and life.But after entering 1980s,along with the development of social economy,the economical globalization has caused the cultural globalization,the vulgar literature expands fast,the elegant literature withers suddenly,the vulgar culture,which crushes the elegant culture,resides in the mainstream status of Chinese literature.In this thesis,based on analyzing this change,the author posts the relationship between elegance and vulgar and advocates the literature view combining elegance and vulgar.


The first case of Kawasaki syndrome presenting as acute severe hepatitis with coagulopathy, in association with an acute Epstein-Barr virus infection is reported. This case supports the hypothesis that Epstein-Barr virus may play a role in the etiology of Kawasaki syndrome and serves as a reminder that a diagnosis of Kawasaki syndrome should be considered for a persistently febrile child, even in the face of an atypical presentation.


Tropical species are highly valued timber sources showing a large diversity of wood characteristics. Since there are major concerns regarding the sustainability of these tropical species in many tropical regions, knowledge of the variability in wood properties is therefore a valuable tool to design targeted exploitation and to enlarge the wood resources base, namely by identifying alternatives for CITES-listed species. In this study, 98 tropical wood species belonging to 73 genera from India, Mozambique, and East Timor were investigated regarding wood anatomy and physical properties. Numerical taxonomy, by means of cluster analysis and principal component analysis grouped species with anatomical and physical similarities from different geographical origins. In addition to wood density, ray and vessel characteristics as well as wood moisture and wood shrinkage properties explained the main variability of these species. The contribution of wood color patterns was highlighted as consistently separating the Mozambique woods. A distinct geographical pattern was not observed, reinforcing that species from India, Mozambique, and East Timor show similar anatomical and physical wood properties, which could be useful to increase timber trade diversity. The multivariate analysis showed that species from Mozambique, such as Morus mesozygia, and Millettia stuhlmannii and Swartzia madagascariensis, could be alternatives for the CITES-listed species Cedrela odorata and Dalbergia melanoxylon, respectively.


Arrays of optical antennas reflect and refract beams with angles that depend on the phase shift gradient along the surface with respect to the incident beam. These beams obey generalized Snell's laws with negative refraction and reflection over certain ranges of the angle of incidence, as well as modified critical angles for reflection and critical angles for reflection. When the phase gradient forms an angle with the plane of incidence, the refracted and reflected beams are no longer coplanar, giving rise to a three dimensional generalization of the above laws that allows unprecedented opportunities to manipulate beams and engineer wavefronts.


In the setting of cryptographic protocols, the corruption of a party has traditionally been viewed as a simple, uniform and atomic operation, where the adversary decides to get control over a party and this party immediately gets corrupted. In this paper, motivated by the fact that different players may require different resources to get corrupted, we put forth the notion of resource-based corruptions, where the adversary must invest some resources in order to corrupt a player.
 If the adversary has full information about the system configuration then resource-based corruptions would provide no fundamental difference from the standard corruption model. However, in a resource "anonymous" setting, in the sense that such configuration is hidden from the adversary, much is to be gained in terms of efficiency and security.
 We showcase the power of such hidden diversity in the context of secure multiparty computation (MPC) with resource-based corruptions and prove that anonymity it can effectively be used to circumvent known impossibility results. Specifically, if OPT is the corruption budget that violates the completeness of MPC (the case when half or more of the players are corrupted), we show that if hidden diversity is available, the completeness of MPC can be made to hold against an adversary with as much as a B ⋅ OPT budget, for any constant B>1. This result requires a suitable choice of parameters (in terms of number of players and their hardness to corrupt), which we provide and further prove other tight variants of the result when the said choice is not available. Regarding efficiency gains, we show that hidden diversity can be used to force the corruption threshold to drop from 1/2 to 1/3, in turn allowing the use of much more efficient (information-theoretic) MPC protocols.
 We achieve the above through a series of technical contributions: The modeling of the corruption process in the setting of cryptographic protocols through corruption oracles as well as the introduction of a notion of reduction to relate such oracles; the abstraction of the corruption game as a combinatorial problem and its analysis; and, importantly, the formulation of the notion of inversion effort preserving (IEP) functions which is a type of direct-sum property, and the property of hardness indistinguishability. While hardness indistinguishability enables the dissociation of parties' identities and the resources needed to corrupt them, IEP enables the discretization of adversarial work into corruption tokens, all of which may be of independent interest.


Objectives:Although metabolic syndrome is associated with increased sympathetic activity that chronically stimulates &bgr;-adrenoceptors, the &bgr;-adrenoceptor signaling pathway has been poorly studied in this situation. We studied the &bgr;-adrenoceptor signaling pathway in Zucker lean, obese, and obese diabetic rats. Design:Experimental, prospective study. Setting:University medical research laboratory. Subjects:Adult male Zucker lean (control), obese, and obese diabetic rats. Interventions:The effects of &bgr;-adrenoceptor stimulation were investigated in vitro in isolated left ventricular papillary muscles in control, obese, and obese diabetic rats. &bgr;1-, &bgr;2-, and &bgr;3-adrenoceptors and multidrug resistance-associated protein 4 were quantified by Western Blotting. Triglyceride, cholesterol, leptin, adiponectin, and C-peptide plasma concentrations were measured. Data are mean ± SD. Measurements and Main Results:Hyperlipidemia, high leptin, and C-peptide concentrations were observed in obese and obese diabetic strains, whereas hyperglycemia occurred only in the diabetic strain. The positive inotropic effect of isoproterenol was slightly reduced in obese rats (183% ± 11% of baseline; p = 0.003; n = 7) and markedly reduced in obese diabetic rats (137% ± 18% of baseline; p < 0.001; n = 10) when compared with control rats (210% ± 17% of baseline; n = 9). &bgr;1-adrenoceptors were down-regulated in obese (–41%; p = 0.02) and diabetic (–54%; p = 0.003) when compared with control rats, whereas &bgr;3-adrenoceptors and multidrug resistance-associated protein expression remained unchanged. Direct stimulation of adenylate cyclase with forskolin or administration of 3′,5′-cyclic adenosine monophosphate suggests that subtle impairments also occurred beside the down-regulation of &bgr;1-adrenoceptor. Conclusions:The positive inotropic effect of &bgr;-adrenoceptor stimulation is slightly decreased in Zucker obese rats and was more markedly decreased in Zucker diabetic rats. These decreases are mainly related to &bgr;1-adrenoceptor down-regulation.


A method to enumerate self-avoiding convex polygons, which in theory will work for all dimensions, is presented. The generating series for polygons of dimensions 2 (already known) and 3 are given. They are both the quotients of two D-nite series, and it appears that this property might hold for higher dimensions.


The present invention has been aimed to install the vertical trench, and a slope of the trench to isolate the large device for the separation of small devices in one semiconductor chip together, and also to obtain this without the need for a complex and expensive process , by the semiconductor substrate 10 to form a resist pattern having a window of at least two types of different widths, selecting the irradiation angle of the ion beam is a fluorine ion narrow window (31 35) includes a substrate region between the no-pass, wide windows 36, 37 to pass by, and to impinge on the substrate, when the anisotropic etching of the substrate in the following a narrow window is etched perpendicular to the trench (51 55) between the substrate region is, a large window width is chant a infusion Are selectively etched by including a region having an ion gradient is a trench (56, 57).


OBJECTIVE
To analyse patients with cholesteatoma undergoing canal wall down mastoidectomy together with ossicular reconstruction with a titanium prosthesis, in order to identify factors associated with hearing outcomes.

STUDY DESIGN
Retrospective review of 97 cases undergoing single-stage surgical management.

METHODS
All patients underwent canal wall down mastoidectomy. Kurz titanium ossicular prostheses were used for ossicular chain reconstruction. Pre-operative and post-operative air conduction and bone conduction hearing thresholds were obtained at 500, 1000, 2000 and 3000 Hz.

RESULTS
The mean pure tone average improved from 46.02 ± 14.54 dB pre-operatively to 29.32 ± 14.64 dB post-operatively, for both total and partial ossicular replacement prosthesis groups combined. The mean air-bone gap improved from 30.38 ± 11.12 dB pre-operatively to 15.62 ± 9.65 dB post-operatively, for both groups combined.

CONCLUSION
Reconstruction with a titanium prosthesis offers good functional results when performed during canal wall down surgery for advanced cholesteatoma, as a single-stage procedure.


During a time of change in HE we need to make sure we are broadening access to knowledge, enabling global mobility, being competitive and embracing new technologies - how do we do this?


The photodissociation of HCl/MgO (001) is studied by classical molecular dynamics of a single adsorbate system including the substrate phonon modes. An important quantum effect is accounted for by taking the hydrogen coordinates and momenta in the initial state from a vibrational ground state wave function. In the angular distribution of the scattered photofragments characteristic structures due to rainbows, scattering shadow and resonances are found, that are already well described within the rigid surface approximation. The hydrogen kinetic energy release also shows a pronounced peak structure corresponding to different energy transfer mechanisms and is significantly affected by inclusion of energy transfer to the phonon modes. Due to multiple collisions with the surface and the chlorine, the hydrogen can lose more than 3.5 eV of its 4.7 eV excess energy. The angular resolved energy spectrum is explained by several types of trajectories connected with the above mechanisms. The results suggest further that the different mechanisms can be separated in an experiment.


This exploratory study aims to: 1) determine objectives, materials, methods, media and evaluation of history teaching in senior secondary schools; 2) identify factors that support and inhibit history teaching in senior secondary schools; 3) exploit the understanding of history teachers of senior secondary schools on history teaching models; and 4) establish a model for character education based-history learning. Research subjects are history teachers of senior secondary schools in Solo Raya. Data were collected using observation, interviews, document analysis, questionnaire and Focus Group Discussion techniques, and analyzed using the method of qualitative interactive model. The results showed that: 1) purpose of history teaching inculcate the spirit of nationalism, love of nation and homeland; materials in accordance with the Content Standards; lecture methods varies, power point media, film and Liquid Crystal Display, while the evaluation is still tend to focus on cognitive aspects; 2) supporting factor of history teaching is the development of innovative learning models, while the inhibiting factors are the lack number of BSE book and discrimination on the subjects; 3) majority of history teachers of senior secondary schools have understood the learning models, and 4) completion of the Critical, Creative, Chain and Character model (KKBB).


Patients with Diabetes Mellitus (DM) have accelerated atherosclerosis, which is the main essential factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the principal cause of morbidity and mortality in patients with DM. Both atherosclerosis and the increased risk of thrombotic vascular events may result from dyslipidaemia, endothelial dysfunction, platelet hyperreactivity, an impaired fibrinolytic balance, and abnormal blood flow. Platelets of DM patients are characterised by dysregulation of several signalling pathways causing increased adhesion, activation and aggregation. Platelet function of patients with DM is complicated by several mechanisms, such as hyperglycaemia, insulin deficiency and resistance, associated metabolic conditions, and cellular abnormalities. The present manuscript purposes to provide a review on the up-to-date status of data on platelet abnormalities that characterise patients with DM.


Wolbachia are widespread maternally-inherited bacteria suggested to play a role in arthropod host speciation through induction of cytoplasmic incompatibility, but this hypothesis remains controversial. Most studies addressing Wolbachia-induced incompatibilities concern closely-related populations, which are intrinsically compatible. Here, we used three populations of two genetically differentiated colour forms of the haplodiploid spider mite Tetranychus urticae to dissect the interaction between Wolbachia-induced and host-associated incompatibilities, and to assess their relative contribution to post-mating isolation. We found that these two sources of incompatibility act through different mechanisms in an additive fashion. Host-associated incompatibility contributes 1.5 times more than Wolbachia-induced incompatibility in reducing hybrid production, the former through an overproduction of haploid sons at the expense of diploid daugters (ca. 75% decrease) and the latter by increasing the embryonic mortality of daughters (by ca. 49%). Furthermore, regardless of cross direction, we observed nearcomplete F1 hybrid sterility and complete F2 hybrid breakdown between populations of the two forms, but that Wolbachia did not contribute to this outcome. This study identifies the mechanistic independence and additive nature of host-intrinsic and Wolbachia-induced sources of isolation. It suggests that Wolbachia could drive reproductive isolation in this system, thereby potentially affecting host differentiation and distribution in the field.


The various models of mentoring presented in the international literature can be placed into two main categories, namely, those based on behaviourism which support knowledge transmission, and those based on constructivism which support knowledge transformation. The model presented in this paper is based on constructivism and it has been developed as a supporting practice of adult educators. The two dimensions Group and Reflection are the pillars of the model, while its key components, which are at the same time developmental stages, are: Inspiration, Development, Empowerment, and Action.


Objective:To explore clinical curative effect of thrombolytic therapy in gerontal patients with acute myocardial infarction(AMI).Methods:64 cases of patients with AMI were divided into two groups according to age,older age-group(more than 70 years old,n=31) and control group(less than 70 years old,n=33).All patients were treated with urokinase 1.5 million units,and therapeutic effect and prognosis were analyzed between two groups.Results:There was no significant difference in curative effect and prognosis between groups: 26 cases eusemia(83.87%) and 5(16.13%) cases death in older age-group,29 cases eusemia(87.88%) and 4(12.12%) cases death in control group(P0.05).Conclusion:Thrombolytic therapy is safe and effective in over 70 years old patients with AMI too.


In the simulation the mixed Refrigerant cycle (MRC) to liquefy the natural gas, the calculation of property parameters of the natural gas and the mixed refrigerant (MR) is unavoidable and the solution of the state equation is a important. For the natural gas and MR in the process, the precise of the enthalpy and entropy of the two mixtures calculated by the LKP equation is high. In this paper, the solution method of the LKP equation is discussed, and a method with good convergence is designed. The relation between enthalpy and temperature, pressure, mole percentage of the natural gas and MR is calculated using LKP equation. The calculation method is also suit for other substances.


cabinet racks being closable, in particular metal cabinet comprising at least one of the bins that are separated from each other, are superposed and are each closed by an individual door (6), ventilation openings being provided at least in the doors. The ventilation apertures are arranged in two groups (8a, 8b) of holes or slots extending along the upper edge and the lower edge, over the entire width of each trap door (6).


A main reason for founding the European Union was to remove internal trade obstacles and to establish a Single Market within its borders. Along with the increasing integration of international markets, an ever-increasing diversification of firms in tandem with the development of multinational enterprises is observable. Legislative authorities of the European Union and its member states are faced with the challenge of ensuring that their corporate tax systems keep pace with this economic transformation of companies and markets. Hence, in order to meet the requirements of an integrated European market, in 2001 the European Commission proposed a switch from Separate Accounting to Formula Apportionment as the leading corporate income taxation system in the European Union. Basically, corporate income of multinational enterprises can be taxed according to these two different principles. At present Separate Accounting is applied at the international level, while some countries like the U.S., Canada, Germany and Switzerland use Formula Apportionment at the state or federal level. Under the current system of Separate Accounting each subsidiary of a multinational enterprise is treated as a separate entity subject to national tax law. For this reason multinationals have to value their intra-firm trade using internal transfer prices, which should meet an external standard of comparison, so-called arm's length prices. Because of the very nature of internal trade with firm-specific tangibles and intangibles evaluating adequate transfer prices proved difficult. Consequently, Separate Accounting was identified as one reason for manipulations in favor of profit shifting for tax saving purposes. That is why the European Commission regards the consolidation of profits including cross-border loss offset for calculating a multinational company's tax base as a more suitable approach in the economic union and advocates the Common Consolidated Corporate Tax Base (CCCTB). To allocate the consolidated tax base to the taxing countries a splitting mechanism is needed. Hence, the CCCTB proposal includes a system of Formula Apportionment. A formula apportions a share of the overall tax base depending on the multinational enterprise's geographical economic activity in the respective country. The European Commission favors a common three-factor apportionment formula containing assets, labor and sales to represent the production and consumption side. The European Commission's proposal has initiated a continuing politico-economic discussion about the efficiency and distributional consequences of the transition to Formula Apportionment in Europe.


ChatGPT has piqued the interest of many fields, particularly in the academic community. GPT-4, the latest version, starts supporting multimodal input and output. This study examines social media posts to analyze how the Chinese public perceives the potential of ChatGPT for educational and general purposes. The study also serves as the first effort to investigate the changes in public opinion since the release of GPT-4. According to the analysis results, prior to GPT-4, although some social media users believed that AI advancements would benefit education and society, some believed that advanced AI, such as ChatGPT, would make humans feel inferior and lead to problems such as cheating and a decline in moral principles, while the majority remain neutral. Interestingly, public attitudes have tended to shift in a positive direction since the release of GPT-4. We present a thorough analysis of the trending shift and a roadmap to ensure the ethical application of ChatGPT-like models in education and beyond.


Objective:To investigate the effect of melatonin on neonatal rat hypoxic-ischemic brain injury and nerve protection mechanism.Methods:One hundred and twenty 7-days-old wistar rats were randomly divided into 3 groups: control group(n=40),hypoxia-ischemic group(n=40) and MT-treated group(n=40).The hypoxia-ischemic brain damage(HIBD) model was established via Rice method.The rats in MT-treated group received a single dose of MT10mg/kg intra-peritoneally after hypoxia-ischemic brain injury and the rats in HIBD group received equal amount of normal saline intra-peritoneally.The brain tissue of rats in all experimental groups were harvested at 6,24,48 and 72h after surgery and the NF-κB expression in the hippocampus was measured by immunohistochemical technique.Results:Compared with control group,the level of NF-κB expression was increased significantly with duration of hypoxia-ischemic brain injury of rats in HIBD group(P0.01).Compared with hypoxia-ischemic group and the level of NF-κB expression in MT-treated group was decreased significantly at 24,48 and 72h(P0.01).Conclusion:The protective mechanism of MT may be related to the inhibition of persistent activation of NF-κB.


Abstract Optimization by definition is the action of making most effective or the best use of a resource or situation and that is required almost in every field of engineering. In this work, the optimization of Least Mean square (LMS) algorithm is carried out with the help of Particle Swarm Optimization (PSO) and Ant Colony Optimization (ACO). Efforts have been made to find out the advantages and disadvantages of combining gradient based (LMS) algorithm with Swarm Intelligence SI (ACO, PSO). This optimization of LMS algorithm will help us in further extending the uses of adaptive filtering to the system having multi-model error surface that is still a gray area of adaptive filtering. Because the available version of LMS algorithm that plays an important role in adaptive filtering is a gradient based algorithm, that get stuck at the local minima of system with multi-model error surface considering it global minima, resulting in an non-optimized convergence. By virtue of the proposed method we have got a profound solution for the problem associated with system with multimodal error surface. The results depict significant improvements in the performance and displayed fast convergence rate, rather stucking at local minima. Both the SI techniques displayed their own advantage and can be separately combined with LMS algorithm for adaptive filtering. This optimization of LMS algorithm will further help to resolve serious interference and noise issues and holds a very important application in the field of biomedical science.


The application of multispeed gearbox in pure electric drive gives a significant benefit in electric energy consumption saving. It is visible, especially in the case of city exploitation conditions of the electric vehicle. Independent on the kind of use multispeed transmission its application in pure electric drive required its automated operation, both for vehicle acceleration and deceleration. In the case of Automated Manual Transmission the disadvantage is interrupted driving torque during gear shifting. This negative feature can be removed thanks to the proper drive train structure. One of them is proposed dual motor - single shaft drive structure. It consists of two electric motors. One of them is connected to the multispeed transmission input while the second is connected to the multispeed transmission output shaft and then to the final drive. This way of electric motor arrangement in electric drive structure puts together the benefits of multi speed gearbox application as well as the possibility of vehicles propelling during gear shifting. Additionally, compared to the classic electric drive structure with multispeed transmission, each motor rated power can be limited because the total drive power is the sum of both the motor powers. It is resulting in motors current limitation thus the same the losses are also limited and the drive efficiency increase. It seems that the effect on energy saving can be greater when both motors cooperate together in the proper way. This cooperation depends on both motor torque distribution. The motor torque distribution must be done under best efficiency motor operation condition. In the paper the analyses of the torque distribution influence on efficiency and battery power for the proposed structure of electric drive was done. There was proposed the definition of torque distribution based on the required output torque demand. The factors allowing the evaluation of quality torque distribution have been proposed.


This paper presents results of a research project related to the development of alkali-activated geopolymers, synthesized from alumina-silicate minerals (fly ash and pumice) which are added to concrete. Alkali sources used in geopolymer synthesis were sodium hydroxide and sodium silicate solution. New materials were structurally characterized by Infra-Red spectroscopy (IR) and X-Ray Diffraction (XRD). Concretes obtained after geopolymers addition as Portland cement substitutes at 10%, 20% and 30%, were mechanically analysed by compression resistance at 7, 14, 28 and 90 drying days. Results were referred to standard (concrete of Portland cement) allows to know cementitious characteristics of geopolymers are lower than those for standard, but it keeps growing at longer drying time than Portland cement. By Electrochemical Impedance Spectroscopy (EIS) it is found that this new material shows high electrical resistance and have been proved as a protection agent against corrosion in reinforced concrete exhibiting anticorrosive properties higher than those showed by the conventional concrete mixture.


In the first number of Radiography Open, the article - Knowledge management: How to find the best knowledge sources was published (Nordsteien, 2014). Several free access research databases and resources were presented relating to evidence-based practice (Nortvedt et al., 2012) and the knowledge pyramid of Dicenso, Bayley and Haynes (2009). It is often possible to find a specific article by searching for the title in Google. To find any article on a topic, you will probably succeed by entering the subject in the search field of research databases. However, if the aim is to find all or the best information about a topic, you have to use advanced search techniques. Illustrating how to do a systematic literature search is the aim of this second brief article on knowledge management.


Part 1 Major chronic diseases: epidemiology aetiology and management paediatric asthma Type I diabetes juveline idiopathic arthritis cancer in children cardiovascular responsivity to stress and its impact on future cardiovascular disease in youth. Part 2 Related issues: family considerations stress and coping in children at risk for medical problems.


Audio music piracy has become a perennial problem in Nigeria. Though there are many studies on music piracy, studies have not examined piracy from the perspectives of pirates, musicians and producers. This study was conducted at Alaba International Market, Lagos, which is reputed as the hub of pirated products. Data were gathered via in-depth and focus group interviews. Findings show that piracy involves sourcing, separation, designing of packs and marketing. Owing to the cost of production, pirates provide upcoming artistes with publicity and reduce the cost of production. As a result, pirates see themselves as legitimate marketers and promoters. However, music idols perceive pirates as criminals, although they agree to have enjoyed their 'support' and assistance early in their career. Pirates and upcoming artistes enjoy symbiotic relationship. They use their network, which includes disc jockeys (DJs), and radio and television presenters to promote budding and high profile artistes. Pirates, as self-styled promoters have made themselves vital in the music industry. Despite the negative effects of theft of intellectual properties and drain on finances, both upcoming and popular artistes admitted that music pirates provide fame for a large number of artistes.


Nature‐driven designs for water crisis have shown much interest in energy‐efficient water treatment. This review discusses four different bioinspired systems, aquaporin membranes, mussel‐inspired amine‐based membranes, supramolecular architectures, and cactus/mangrove desalination. The authors have also delineated their contributions and mechanisms toward forming water pathways for effective desalination. The discussion is mainly channelized toward constructing generic approaches based on membranes with diverse shapes and dimensions, including hierarchically structured membranes. The separation properties of these bioinspired systems stem from their chemical and physical structures imparting selectivity in the separation of ions, pollutants, etc. Further, this review covers the practical methodologies for next‐generation energy‐efficient membranes and outlines the perspectives regarding the upcoming developments in water technology.


This study relates to the variability of wood density and compression strength parallel to grain within the stem of spruce trees (Picea abies /L./ Karst.). The sample tree originated from the Giant Mountains and was an adult autochtonous mountain spruce. The properties were analysed for wood that formed between 1850 and 1990 along (1) the north-south oriented radius and along (2) the stem height on test specimens with the following dimensions: 20×20×30 mm, prepared from logs taken from the stem base at distances of 2, 4, 6, 10, 14, 20, 22, 24 and 26 m. In individual sections, the properties of the samples oriented in the north or south direction did not differ, while the effect of different ages on the properties showed statistically significant differences at each orientation (p < 0.05). Along the radius, the properties showed an increasing trend in tree-rings that developed between 1850 and 1940 with a slight decrease in the following years. The coefficient of variation in various decades was 1–7 % (wood density) and 3–15 % (wood compression strength). Along the stem height, the properties gradually increased to a height of 20 m, while the increase in values was more pronounced in the 22–26 m interval. The variability of the wood properties along the stem height corresponded to the variability of the properties along the stem radius. A linear dependence between wood strength and density was demonstrated. Compared to what had been previously written, wood density showed a greater impact, probably due to the biomechanical optimization of the stem with regard to mechanical wind and snow loads in the mountains.


The confining stresses in a concrete column confined with fibre-reinforced polymer (FRP) are uniform across the section and isotropic only when the column is under concentric loading and circular in shape. If the column is under eccentric loading or non-circular in shape, the confining stresses in the column become non-uniform and anisotropic. However, without knowing the confining stresses, it is impossible to predict the structural behaviour of confined concrete columns. To overcome this difficulty, a new finite-element (FE) method was developed based on the most up-to-date lateral strain–axial strain and axial stress–strain constitutive models of concrete. This paper reports on using the method to analyse circular concrete columns confined by FRP under eccentric loading. It was found that, under eccentric loading, the confining stresses are generally smaller at larger eccentricity. Overall, good agreement between the theoretical results and published experimental data was achieved. In theory, the FE me...


In the view of modernity,literary thoughts are responses to modernity from eiterature.Different responses form different eiterary thoughts.This thesis regards Romanticism as "the first animadverting on the modernity".SHEN Congwen's literary works should belong to Romanticism.After making the initial analysis of the differences between Western Romanticism and SHEN Congwen's Romanticism,this thesis points out that SHEN Congwen's works differ from Western Romanticism.The latter chases transcendency,and has aristocratic spirit and mysticism,the former has their unique features: caring about reality,commonality manner,and rational abstinence.


Background Data on peptic ulcers in childhood are insufficient. The aim of this study is to define the frequency and characteristics of peptic ulcer disease (PUD) in children and to compare with PUD due to H.pylori infection and the others. Methods Pediatric patients that underwent upper gastrointestinal endoscopy between July 2008 and July 2019 were examined. Age, gender, clinical presentation, location of peptic ulcer (PU), presence of H.pylori histopathologically and hemoglobine values were recorded for each paient with PUD from the hospital file records. Patients were divided into two groups as patients with PUD associated H.pylori and patients with PUD associated with other etiologies. Then two groups were compared. Results Sixty (0.98%) of 6216 patients were diagnosed with PUD. Sixty patients comprised 32 (53.3%) male and 28 (46.6%) female with a mean age of 10.59±4.89 years. The most common complaint was abdominal pain (n=40; %60.6). H.pylori was detected in 12 (20%) of 60 patients histopathologically. There was no difference between two groups for age, gender, clinical presentation, anemia or location of PU. Conclusion PUD is a rare disorder in childhood. There is no difference between H.pylori related PUD and the others for clinical presentation, anemia or location of PU. For the discrimination of two groups, biopsy should be taken in all patients.


We present the first demonstration of pL-scale analyte index sensing based on surface phonon polaritons in the midinfrared, which are excited at the silicon carbide/analyte interface in the Otto configuration. Attenuated total reflectance measurements reveal analyte index specificity through a double-scan of wavelength and incidence angle for analyte volumes as small as 100 pL. Midinfrared sensing tuned to surface phonon polariton resonance paves the way for index sensing of analytes beyond current volume−resolution limits.


Hereditary persistence of fetal hemoglobin (HPFH) is a genetically heterogeneous and clinically benign condition characterized by persistent expression of fetal hemoglobin (Hb F) into adulthood. In the G, + type. no major deletions in the globin gene cluster occur; adult heterozygotes produce approximately 20% Hb F. which results from overproduction of chains. with no apparent increase in production from the adjacent gene. We have recently described a point mutation 202 base pairs 5' to the cap site of the gene in an individual with G.. fl+ HPFH. This mutation abolishes a normal Apal restriction endonuclease site. and thus can be detected by blotting of genomic DNA. We present here further data on the Apal mutation: (1 ) It occurs in six of seven families with HPFH. (2) In three families. detailed haplotype analysis using 1 1 polymorphic


In this article, I explore the dualism of visible–invisible (henceforth referred to as in/visibility) as a spectrum while utilizing autoethnographic accounts to contextualize my personal experiences traveling through liminal identity spaces. I embrace my in/visible identities as a queer woman in a society entrenched in heteronormativity, a disabled individual whose disability is not always visible, and an assistant professor who carefully navigated her academic career beginning as a non-tenure-track faculty member. Specifically, I explore the various considerations necessary in choosing to disclose (or not disclose) marginalized identities as navigating the gray space between visible and not and how these actions align with the spectrum of dis/comfort. I traverse topics such as how in/visibility can be harmful and powerful, what the ethical considerations are in crossing the border into in/visibility, and finally, how the act of border crossing via self-disclosure, along with engaging in perceived deficits, may at times be strategic. My work is primarily influenced by Anzaldúa's notions of border crossing, nepantla, and New Mestizas.


Scattering dynamics are examined for Gaussian and non-Gaussian wave packets with identical momentum densities. Average arrival time delays, dwell times, and phase time delays are calculated for wave packets scattering from a square barrier, and it is shown that the non-Gaussian wave packets exhibit different average arrival time delays than the Gaussian wave packets. These differences result from the non-linear terms in the momentum wave function phase of the non-Gaussian wave packets, which alters the self-interaction times of the wave packets. Control of the average arrival time delay can be achieved through adjustment of the momentum wave function phase, independent of wave packet energy and momentum density.


The estimation of software effort is an essential and crucial activity for the software development life cycle. It is a problem that often appears on the project of making a software. A poor estimate will result in a worse project management. Several software cost estimation models have been introduced to resolve this problem. Constructive Cost Model II (COCOMO II Model) is a most considerable and broadly used model in cost estimation. To estimate the cost of a software project, COCOMO II model uses cost drivers, scale factors and line of code. However, the model is still lacking in terms of accuracy. In this study, we investigate the influence of components and attributes to achieve new better accuracy improvement on COCOMO II model. We introduced the use of Particle Swarm Optimization (PSO) algorithm in optimizing the COCOMO II model parameters. The proposed method is applied on Turkish Software Industry dataset. The method achieves well result and deals proficient with inexplicit data input and further improve a reliability of the estimation method. The optimized MMRE result is 34.1939%. It can reduce 698.9461% and 104.876% errors from the basic COCOMO II model and Tabu Search coefficient significantly.


The dependence of specific luminescence on the stopping power of /sup 16/ O ions in thin-film plastic scintillator has been determined over a range of incident ion energies which bracket the maximum stopping power. The suggested double-valued dependence of specific luminescence has been confirmed. The pronounced drop in specific luminescence near maximum stopping power is undertood in terms of electron pickup by the slowing ion. (auth)


Language, Space and Power: A Critical Look at Bilingual Education. S. Hadi-Tabassum. Clevedon: Multilingual Matters. 2006. Pp. 1+295. ISBN 1-85359-878-X (pbk): $39.96. ISBN 1-85359-879-8 (hbk): $99.96.


Particulate material is supported in a fluid medium by means of an ultrasonic standing wave while a reaction is effected or controlled involving the material so supported, for example with the fluid medium or other material contained in the medium. In a preferred arrangement, the standing wave is established by opposed ultrasonic transducers producing convergent beams that compensate for attenuation of the ultrasonic energy in the fluid medium, and operating in the near field. The support provided by the standing wave is able to avoid settling of the particulate material in the medium and also agitates the material; both effects enhance the rate of chemical reaction and help to ensure that the particulate material is more uniformly exposed. The process has particular applications to biological reactions, such as fermentation, and to chromatography, as examples.


As in the three previous years, 1995 began with a mild, rainy winter. Budding occurred between 6 and 17 April, one week earlier than in previous years. There was frost at the end of April in the Marne and in mid-May in the Aube. After a short cold spell, end of flowering was excellent thanks to hot, summer weather conditions. July was particularly hot and stormy, accelerating the threat of mildew to an extent not seen since 1958. Care was needed to guard against rot and mildew. August was hot and the grapes ripened well. The harvest lasted from 18 September to 2 October. The juice showed an excellent alcohol/acid balance, reminiscent of 1988.


The local contribution to the action of the O(3) σ model in D = 2 or pure SU(2) gauge models in D ≧ 3 dimensions are expanded and integrated on the group. There results a field of variables j, a 3nj coefficient W({j}) with n ∞ and dynamical factors f(j, β). We prove that for the gauge models a local decomposition of W({j}) into a product of 3nj coefficients with n = 2D(D – 2) exists. We study generating functions for W({j}) or the 3nj coefficients and develop an algorithm for their computation. Some of these generating functions are explicitly calculated.


In higher vocational teaching of law logic and practical logic,the two questions of the difference between muster concept and non-muster concept and the extension relation of concept are main point and difficult point of concept.The key of distinguishing muster concept and non-muster concept is how to master the characteristic of the two concepts.The concrete methods include method of entirety and part,method of classifier measure word restricting etc. Therefore,it makes students improve the effect of using concept.


century to the present. The reputation of Norton Critical Editions is built on presenting works of literary interest in historical and aesthetic contexts. The literary possibilities of the Relacíon are nearly forgotten outside of brief mention in the introduction. Finally, the "Context" and "Criticism" materials have issues for classroom use. The intended audience seems to be advanced undergraduates in Latin American studies classes. The "Context" materials presume knowledge about Columbus's first expedition, the Aztec world, Cortés's ventures, and the leyenda negra. Additionally, the Oviedo y Valdés selections are Krieger's translation from We Came Naked and Barefoot, filled with square brackets insertions that make the text hard to follow, and the RiveraBarnes essay quotes Cabeza de Vaca in Spanish without English translations. From teaching many of these materials, I would say that presumption of historical or language background is not a safe bet. It is not even a safe bet for American literature teachers who want to expand the horizons of their classrooms, but who have been trained primarily in the Englishlanguage literatures of North America. I like the idea of a Norton Critical Edition of Cabeza de Vacas's Relacíon, but for now, I will stick with the broader introduction of Favata and Fernández for undergraduates and with Adorno and Pautz for graduate students with their rich historical and bibliographic materials.


There have been recent concerns about the propensity of calcium and vitamin D supplementation to cause cancer. In osteoporotic patients, this has led to increasing recommendations advocating the replacement of calcium supplementation with dietary or other means. Around the world, the problem of vitamin D deficiency remains, being a large contributor of rickets and osteomalacia in the developing world and osteoporosis in post-menopausal women and people dependent on long-term corticosteroid treatment. We review the alternatives of vitamin D supplementation through dietary, other natural supplements as well as sunlight therapy, in an evidence-based manner. We will also review the safety aspect of each modality.


The marine water fish Dasyatiswalgacollected from Ratnagiri district during the period of June 2018 to May 2019. After dissection their intestinal passage was examined for tapeworm parasite.The genus Uncibilocularis was established by Southwell (1925) with its type species U. trygonis (Shipley et Hornell 1906),the histopathological studies were carried out and observation clearly shows that the parasite, UncibilocularisdasyatisiiSp.Nov. was approaching to the intestinal villi, embedded in the fibroblast cell and is attached to the intestinal villi. Thehistopathological studies of tapeworm UncibilocularisdasyatisiiSp.Nov. Have been studied to find the pathological changes and extendof damage of the intestinal layers of Dasyatiswalga.


Prunus cerasus L (Sour cherries) contain diverse secondary metabolites which exhibit various biological activities, including anticancer, antioxidant, and anti-inflammatory properties. The present study aimed to determine the anticancer efficacy of four compounds, quercetin, daidzin, rutin, and chlorogenic acid, isolated from Prunus cerasus fruit. The antiproliferative activity of four cherry isolates was determined against five different cancer cell lines (NCI-H322, A549, THP-1, MCF-7, and PC-3) by Tetrazolium bromide assay, followed by apoptosis Cell cycle analyses, mitochondrial membrane potential, cell migration test, and in vivo Ehrlich Ascites Carcinoma studies using potent bioactive lead. The cytotoxicity profile of the four molecules demonstrated that quercetin induced significant cell growth inhibition in all cancer cell lines with paramount 79% cytotoxicity against NCI-H322 lung cancer cells (IC50 value 24μM). Incubation of NCI-H322 cells with quercetin showed a concentration-dependent increase in hypo-diploid sub G0/G1 DNA fraction, exhibited consequential changes in nuclear morphology, and caused mitochondrial transmembrane potential loss of 60.3% augmented at 30 µM. Pertaining to in vivo potency, quercetin manifested 89% tumor inhibition at 50 mg/kg body weight in EAC-bearing mice. The current studies raise the potential usefulness of quercetin in chemoprevention against lung cancer cells and support its empirical use as a promising nutraceutical agent.


Anglican Communion. Bishop Christopher Hill and Dr Mary Tanner contribute strong pieces on ARCIC and the influence of its ecclesiology on The Windsor Report 2004. Bishop Andrew Burnham, one of what are affectionately known as 'the flying bishops,' pleads for recognition of the priesthood of Evangelical clergy by Anglo-Catholics. Mary Tanner perceptively says that the rumbling crisis within the Anglican Communion has come at the wrong time for two reasons: theological change is being made to happen at the same time as institutional change. The Anglican world can only hold itself responsible because so little of the implications of Lambeth 1998 were addressed postLambeth ahead of the consecration of Gene Robinson in 2003. I suspect that Anglicans emerge as an odd bunch. The voices are overwhelmingly English. There is neither sight nor sound of an African or Asian Member of SSC. The emphasis is very ecclesial. Only twice is the Inter Faith reality mentioned, though in each case in a confident and sensitive Christian way. The argument for a universal primacy in the person of the bishop of Rome for both Anglicans and Roman Catholics is addressed to a captive audience. I think it has much less general appeal than we are led to believe. Professors David Browne and Ann Loades of Durham teach us to learn again from the arts in a variety of media. The outstanding contribution remains that of the archbishop of Canterbury. In being theological it is properly christological. An optimist in a barren land, he can still adapt the motto of the Anglican Communion, The truth will set you free, to speak of: 'the truth that makes us happy' (p. 11). What a man! The book contains some minor typographical errors. The original Greek words are consistently accented incorrectly. All in all, it is a fascinating and upbeat read. ✠ MICHAEL JACKSON Fivemiletown, Co. Tyrone Sweet and Blessed Country: The Christian Hope for Heaven. By John Saward, New York: OUP, 2005. Pp. 210. Price $22.00. ISBN 0-19-928009-6.


The feasibility of using modern convolutional neural networks solutions in the field of terahertz (THz) imaging was discussed. Characteristics of the 0.14 THz postal scanner for the concealed items detection was described. The methodology for image recognition from the THz postal scanner application was considered. The application of the architectures from the Tensorflow Object Detection library to an instance segmentation and object detection problems of the concealed items was described.


In a real plate heat exchanger (PHX), heat transfer from the hot to the cold fluid is a conjugate problem, in which longitudinal heat conduction (LHC) along the walls plays some role. Large-scale LHC is always detrimental to the exchanger's effectiveness. On the contrary, if significant non-uniformities exist in the distribution of either convective heat transfer coefficient, small-scale LHC may actually enhance the performance of a PHX by improving the thermal coupling between high heat transfer spots located on the opposite sides of the dividing wall.


Strategic management accounting doesn't transform the quality and function of traditional management accounting.It gives full play in all processes of business management.So it is the development of the traditional management accounting instead of a branch.Strategic management accounting pays attention to the analysis of competitors and influence of condition's change.It has an allaround characteristics also.These feature make the strategic management accounting,meet the objective needs in the new economic situation.So it becomes the direction of the management accounting.


Fore skin samples were collected after surgical excision from boys below 7 years of age from Deccan Medical College –Hyderabad, in cold saline (4 0 C) in sterile containers. These skin samples were cut into small pieces and incubated in trypsinised phosphate buffer saline (PBS) overnight to dissociate epidermis from the dermis. The epidermal layer which got detached was lifted and taken for preparing the cell suspension. Viability of cells was 88% with PI staining. About 50 µl of cell suspension was aliquoted into vials (10 5 cells/per vial ) and incubated with 2 µl of the antibodies. Various biomarkers of stem cells such as CD34 – one of the marker's of skin stem cell, CD 49f & CD29 - common stem cell markers, CD45 Lymphocytic marker, CD90 (Thy-1) skin stem cell marker and CD105 endothelial marker and CD56 (NCAM) neural adherent marker were used . Using these cell surface markers of stem cells, cytometry was performed on a FACS Calibur with sorter (BD Biosciences). These immunophenotypic markers with Cellquest software expressed the stem cells characteristics. FACS analyses gave different profiles of stem cells /progenitors of mesenchymal, hematopoietic and neural progenitors. These expressed profiles indicated that its progenitor might have the multipotent and or pluripotent character. By using embryonic markers, we could select a population of stem cells to give multipotent or pluripotent cells that could have the capacity to regenerate skin cells for application in burn cases, wounds, deep burns and non-healing wounds. In conclusion, we present here for the first time the isolation of pluripotent / multipotent skin stem cells from human foreskin biopsy samples and its potential applications for various applications.


Eggs and larvae of the white croaker, Genyonemus lineatus, were collected near the San Onofre Nuclear Generating Station in 1978 and 1979. A developmental series based on 59 eggs and 1681ar vae and early juveniles was assembled. Live G. lineatus eggs are pelagic, transparent, and spherical, averaging 0.85 mm in diameter with a single oil droplet of 0.23 mm. Preserved, newly hatched larvae average 1.57 mm SL and are not well developed. Larval development is a gradual process. Notochord flexion begins at ca. 5.4 mm SL and is complete by ca. 6.4 mm SL. Dorsal and anal fin anlagen appear at ca. 5 mm SL and the full complement of rays is present in each fin by ca. 8.2 mm SL. Pelvic differentiation begins at ca. 5.3 mm SL and is finished by ca. 8.6 mm SL. Pectoral rays begin to develop at ca. 7.8 mm SL and all are present by ca. 13 mm SL. Larval pigmentation is largely restricted to the dorsum at hatching, but migrates to the ventral midline during early development. Melanophores are restricted to the ventrum and gut through much of the subsequent larval period. A barred pattern develops during transition to the juvenile stage. Genyonemuslineatus larvae are distinguishable from similar cooccurring species by the presence of a nape melanophore and larger melanophores in the midventral trunk series at myomeres 9-lD and 16-18. The sciaenid genus, Genyonemus, is represented by a single species, G. lineatus (Ayres), the white croaker. It occurs along the west coast of North America from central Baja California to south ern British Columbia (Miller and Lea 1972), although its numbers are reduced north of San Francisco, Calif. (Frey 1971). In southern Cali fornia the white croaker is a common inshore species of modest sport and commercial value (Skogsberg 1939; Frey 1971). Its larvae rank sec ond in abundance only to those of the northern anchovy, Engraulis mordax, among the inshore ichthyoplankters off San Onofre, Calif. (Walker


ORGANIZATIONAL COMMUNICATION IN PUBLIC INSTITUTIONS AS STIMULUS FOR INTEGRATION AND PROFESSIONAL PRACTICE: THE CASE OF THE COMMUNICATION CABINET IN THE DEPARTMENT OF JOURNALISM II IN THE UNIVERSITY OF SEVILLE (SPAIN) In the current organizations, both public and deprived, the department of communication has a special relevancy, so much it is so there becomes necessary a strategic transverse planning and a complete reconsideration of the social projection of the entity and his responsibilities and perspectives of future. The creation of an office of communication in a university journalism department is a good stimulus for the integration of all his members as to facilitate the incipient development of the journalistic profession in the pupils. Likewise, the strategic situation of this new qualified, inserted issuer in a group of educational journalists, increases the possibilities of theoretical practical learning of the gone away futures. The activity of a university department cannot limit to academic, investigative and bureaucratic matters. In spite of being very important and even essential all of them, it is necessary to rethink and to apply technologies that stimulate the intercommunication between the collective subject, at the time that they are useful to grant a bigger prominence to the paper of the representatives of the pupils in the department. So this is an initiative that it tries to improve the communication so much internal as day pupil of the Department of Journalism II of the University of Seville. At the same time, the project seeks to promote the participation of the students in a practical activity related directly to his future professional labor, following like that the pedagogic trend of the offer of Degree realized by the La comunicación organizacional en instituciones públicas... Ramón Reig


Objective To explore the distinguish method of EMA and PCNA in the renal cell carcinoma.Methods Detected EMA and PCNA of 82 cases in the renal carcinoma by immunohistochemical method,compared the positive expression between EMA and PCNA,and the relationship with the different pathological type of renal cell carcinoma.Results The positive expression of EMA in the renal cell carcinoma was 75.60%(62/82),mainly located in the cytoplasm and cytomembrane.The survival rate of 62 cases with positive expression of EMA was 71.42% which was higher than 20 cases with negative expression(28.57%)(χ2=4.32,P0.05).The positive expression of PCNA in the renal cell carcinoma was 78.05%(64/82),mainly located in the caryon.The survival rate of them was 71.42% which was lower than 18 cases with negative expression(72.85%)(χ2=3.76,P0.05).In the different pathological type of carcinoma,the positive expression of EMA in the typeⅠwere higher than that of the type Ⅱ and Ⅲ,the positive expression of EMA in the typeⅡwere higher than that of the type Ⅲ(χ2=4.77,9.12,9.98,P0.05).The positive expression of PCNA in the typeⅠwere lower than that of the type Ⅱ and Ⅲ,the positive expression of PCNA in the typeⅡwere lower than that of the type Ⅲ(χ2=3.86,8.42,7.95,P0.05).The other comparisons had no statistically significant difference(χ2=0.58,2.39,16.94,0.71,8.04,3.01,P0.05).Conclusions EMA and PCNA would indicate the grade malignancy and the prognosis of renal carcinoma to a certain extent.It would be used to distinguish differentiated carcinoma.


Summary

A slightly modified critical-state model was formulated in order to account for the volume-change behaviour at yield and failure observed in triaxial tests on unsaturated soils. Model parameters were specified for two soils (a sandy loam and a loam), each at three different soil-moisture contents. Maximum shear strain was integrated numerically for 36 cylindrical load paths with constant confining pressure (type I) or constant mean normal stress (type II). Predicted stress-strain relationships for load paths bringing soils from a normally-consolidated to a critical state were compared with stress-strain relationships observed for identical load paths in triaxial tests of the lubricated ends variety.

The agreement between predicted and observed maximum shear strain depended on type of load path and soil-moisture content. The model failed to predict maximum shear strain at stress states close to critical. The absolute difference between observed and predicted strain was on average ≤0.05 for deviatoric stresses smaller than 90% of the critical-state values. The comparable maximum differences were 0.11 and 0.07 for load-path types I and II, respectively. The largest differences were found for the largest soil-moisture contents. The type of load path had a considerable effect on sample distortion, type I giving rise to larger (predicted and observed) maximum shear strain at common stress states.


INTRODUCTION Since the advent of population genetics and the introduction of the coefficient of inbreeding (Wright 1922, 1923), pure breeds of livestock were regularly submitted to genetic analyses regarding their inbreeding and effective size. Lush (1946) published the first summary of the results of such studies carried out in cattle, pig and horse breeds. Artificial insemination by a limited number of sires of superior genetic merit and selection for progeny test of young bulls out of a small number of sires can turn a large population into a population with a rather small effective size. Inbreeding appears therefore as a corollary of genetic improvement and is an increasing concern in several cattle breeds (Boichard et al. 1996, Young and Seykora 1996, Smith et al. 1998, Hanset 2000, Weigel and Lin 2000).


Brake discs are one of the important auto parts in the motorcycle industry which directly effect life safety. As a result, this research aims to test the performance of brake disc in order to study how the physical shapes of the brake disc affect braking. The braking performance tester was designed and created in the single dynamometer which was referring to the testing state of JASO T204:2001 standard, this tester focused on testing the 3 different types of brake disc i.e. normal type, grooving type and perforated type. The tested temperature was at normal state (60°C - 80°C) and at high state (more than 100°C). The result revealed that at normal temperature, the braking performance of the three brake discs (normal type, grooving type, and perforated type) was at 7.29, 9.10 and 9.50 m/sec 2 per 1 m 2 of contact areas respectively. However, the brake performance at high temperature was at 7.21, 9.03 and 9.46 m/sec 2 per 1 m 2 of contact areas respectively. This meant that the most efficient brake disc at normal temperature was perforated type which was 30.32% better than normal type. Furthermore, the perforated type was the highest performing brake disc at high temperatures, which was better than the normal type by 31.21%.


To clarify the characteristics of winter lightning on the Japan Sea coast in the Tohoku region including Niigata Prefecture and the aspects of damage to building equipment, electrical equipment, communication equipment, and so forth, research activities including an on-site survey of lightning damage have been conducted. In this paper, the results of investigating damage due to winter lightning in the Tohoku region are described.


Objective To investigate the effects of needle bevel down on relieving pain resulting from intravenous transfusion of acanthopanax senticosus.Methods Forty patients with transfusion of acanthopanax senticosus via peripheral veins in the neurolgoy department were randomly divided into experimental group and control group in even.After the successful venipuncture with needle bevel up in the experimental group,the needle handle was rotated 180 degree gently and slowly with bevel down and the right wing of needle handle was rotated to left side.Routine method was applied in the control group with needle beval up during veinpuncture and anchor.Results The pain score in the experimental group and the control group was(2.20±0.27) and(3.95±0.30) respectively,and there was significant difference between two groups(P0.05).Patient satisfaction score in the experimental group and control group was(24.03±3.90) and(12.61±5.20) respectively and there was also significant difference(P0.05).Conclusion Needle bevel down can effectively relive the pain resulting from intravenous transfusion of acanthopanax senticosus.


In this extended abstract we describe how CC/PP, a framework for describing user preferences and device capabilities, can be extended to support general contextual information. Whilst there has been some concern for privacy issues in the intended uses of CC/PP, this more general use increases the need for protecting sensitive contextual information. We describe how an additional privacy profile can be used together with P3P, to determine what information is revealed.


Much research has been dedicated to the interaction between flow and vegetation,
however, this knowledge is only to a limited extend incorporated in models that are being used for river management practices. This may be partly due to the unknown reliability of the developed flow formulas. This contribution evaluates five different flow formulas derived for submerged vegetation: Klopstra et al. (1997); Stone and Shen (2002); Baptist et al. (2007); Huthoff et al. (2007); and Yang and Choi (2010). Each of these models is based on measurable vegetation characteristics to account for flow resistance by the vegetation. The evaluation of the flow formulas is based on the agreement with experimental data from literature, on their behaviour with respect to submergence ratio and
on predicted water levels for different vegetation types. All models showed reasonable correlation to experimental data for rigid and flexible vegetation, however, average relative deviations were quite significant in the range of 24 to 43%. Some models showed unexpected behaviour in the ratio of the flow velocities in the surface and vegetation layer and deduced roughness parameters
as function of submergence ratio. Predicted water levels for a given velocity varied up to several meters for some vegetation types. This shows that a particular choice for a model may have huge consequences when being used to predict water levels during flood conditions. The flow formulas proposed by Klopstra et al. (1997) and Yang and Choi (2010) show the best fit to experimental data and also show consistent physical behaviour


Worldwide, networked computers provide extensive resources for family communication scholars extending well beyond the obvious, digital library files of published research. The purpose of this article is not to review all possible Web-based resources. Instead, I will provide an organizational schema for such information and then review exemplar and important sites within these categories. I will employ the traditional criteria used in evaluating print information and for reviewing Web sites, with additional consideration given to the unique dynamics of Web-based publishing.1 To develop my employed schema, I conducted an extensive search of Internet files using customized search utility software. I limited my search using the single, inclusive term family communication and then correlated the custom search results to general search results obtained through multiple popular search engines including AskJeeves (http://aj.com), AltaVista (http://www.altavista.com), DOGPILE (http://www.dogpile.com), and Mamma (http://www.mamma.com). Keyword searches of these merged listings suggested the following four broad categories of Web sites: individual family, commercial, nonprofit, and government.


In this work we formulate and study a Travelling Salesman Problem (TSP) for a scenario in which two different vehicles cooperate so as to perform a desired task in an optimal way. In particular we consider the problem where a fast vehicle with a short operative range has to be coordinated with a carrier vehicle, typically slower but with virtually infinite operativity range, in order to visit in the shortest time a given collection of points.


Automated detection of EVs from smart meter data can provide important insights for DSOs about spatiotemporal EV charging patterns. However, smart meters typically provide only hourly measurements of consumption while most load disaggregation techniques require at least minute level data. We use machine and deep learning methods to detect EV signatures in hourly smart meter data. Models are trained and evaluated on labelled data, before being tested on unlabelled field data. While balanced models catch about 75% of EVs at false positive rates of 35%, tuned models detect up to 90% of EVs with 10% false positives. When using models to detect EVs on unlabelled Norwegian smart meter data, detections are in line with EV fractions from the national registry as well as expected spatiotemporal patterns. However, models may be confused by baseline consumption patterns. Collection and inclusion of labelled EVs is therefore the next step.


Department of Energy, nor any of their employees, nor any of their contractors, subcontractors, or their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product or process disclosed or represents that its use would not infringe privately owned rights. 2 Acknowledgments An earlier version of this paper appeared as an Energy Lab Working Paper (75-009WP). Since then, the storage algorithm has been changed substantially, time-dependent generators have been included, and frequency and duration techniques have been incorporated. The impetus for changing the storage algorithm came from a discussion with Jacob Zahari of Tel Aviv University. Others who have contributed in one way or another to this paper are: Moriarty and Richard Tabors who are now or who have recently been at MIT,


In most of the complex Finite Element (FE) Modelling analyses sub-components if included in the global model of structure may cause extremely large problem size. This would not render themselves to a cost-effective analysis solutions. This is due to modelling efforts, post-analysis processing efforts & time factor involved. A rational yet costeffective approach is to go for an application of concept of sub-structuring for design of local regions e.g. floor slabs as presented in this paper. The extent of the sub-structure could be limited adequately beyond the region of interest. INTRODUCTION Internal Structures (IS) of Reactor Buildings of Nuclear Power plants are complex Reinforced Concrete (RC) structures in terms of structural analysis, design & construction. Structural analysis is carried out on a Global Finite element model. In the global model representation of floor in its finer form to model local areas, cut-outs etc is not necessary, since focus is on the design of walls. As far as the design of floors is concerned, element results for some floor regions in the global model can not be used because coarse meshing has represented the floor. Due to large size of mathematical problem, the concept of sub-structuring is employed which is rational. This paper illustrates the application of sub-structuring in the complex environment to analyse & design of floor slabs. STRUCTURAL ARRANGEMENT The IS of Reactor building comprises of RC floors, RC walls, RC & structural steel columns. A typical floor considered in the paper is a reinforced concrete floor. General slab thickness about 1000 mm. Floor is constructed with concrete mix with heavy density aggregate as a radiation-shielding requirement. The floor slab is constructed integrally with RC wall beam-arrangement. The floor has circular periphery around; the floor has cut-outs as operational requirement of the plant. The whole structure is supported on a common mat foundation. NEED OF SUB-STRUCTURING AND MODEL ADOPTED Being a part of a complex three-dimensional Internal Structure (IS) consisting primarily of RC walls, RC floor slabs, and columns of RC & steel; modelling of the structure is an appreciably complex job. (Refer Fig. 1). The structural geometry is symmetric about the East-West centre-line. As such North half of the structure is modelled & analysed with appropriate boundary conditions on EW symmetry plane depending upon the loading layout either symmetric or antsymmetric. A general refinement of the global model would end up into an un-manageable analytical model in terms of computer memory, time etc. Further it is computationally intensive work due to a variety of loading types, load combinations, scrutiny for critical combinations & finally the element-wise reinforcement design. As far as design of floors is concerned, it was contemplated that element results of global model would not provide reasonably accurate information like membrane forces, bending moments, and out of plane & in plane shear forces for design of floors. As such it was considered to adopt sub,structuring approach for the floor. In the domain of sub-structure; along with the floor of interest, its connecting walls above & below are included up to next floor levels above & below but excluding those floors (Refer Fig.2). The element regions of the floor are subdivided, forming a finer mesh. For enhanced accuracy, isoparametric 8-node shell element is used for discretising the sub-structure. This element provides benefit of calculations of transverse shear forces as well as it accounts for shear deflections. Sets of displacement boundary conditions are specified at nodes common between sub-structure & global model depending upon the nature of the load as described in next paragraph. Types Of Loading The structural analyses for global model & sub-structure are carried out for loading like self weight of structure, floor live loads during normal operating conditions as well as during erection & shut-down conditions, hydrostatic loading, equipment loads (Ro), operating temperature (To), accident pressure (Pa), accident temperature (Ta), seismic loading like SSE & OBE along NS, EW &Vertical directions. Global Model Structural analysis of the global three-dimensional model of Intemal Structure is carried out wherein the floor slabs, walls, columns are included in the model (Refer Fig.l). The quadrilateral shell element & three-dimensional elastic beam element used are used for the design of walls & columns of the structure. The floor slabs are modelled coarsely to represent essentially their in-plane rigidity. For this reason, these results obtained for floor slabs can not be used for design of floors. Procedure adopted, for global analysis is outlined as under; • Structure as a whole being symmetric, half structure is discretised, with nodes on symmetry plane appropriately restrained depending upon symmetry or anti-symmetry of loads. • Nodes at junction with mat foundation are fixed in all six Degrees Of Freedom (DOF). • FE analysis of the entire structural system (global model) is carried out for the load cases individually. • Displacement results of global model after analysis are extracted for the nodes defining the boundaries (to be applied on the substructure defined below). These displacements would serve as boundary displacements for sub-structure described below.


In the early 1980s, a new type of polyamine toxins was found in the venom of several orb-web spiders. Joro spider toxins (JSTXs) in the venom of Nephila clavata and Nephila spider toxins (NSTXs) derived from Nephila maculata blocked postsynaptic glutamate receptors in the invertebrate and vertebrate nervous system. Subsequently, chemical characterization and synthesis of JSTXs and NSTXs were carried out. These toxins and a synthetic analog, 1-naphthylacetylated spermine (Naspm), effectively suppressed glutamate channel responses of AMPA/KA type in mammalian central neurons. By use of recombinant subunit receptors expressed in Xenopus oocytes, JSTX was found to cause subunit specific block of the Ca2+-permeable AMPA receptors. This specific nature of JSTX was utilized to identify Ca2+-permeable AMPA receptors in various neurons and glial cells. The JSTXs strongly suppressed excitatory postsynaptic currents (EPSCs) in the hippocampal CA1 neurons after transient brain ischemia. The results indicate that JSTXs are effective at blocking abnormal EPSCs that may induce Ca2+ accumulation leading to delayed neuronal death after transient ischemic insult. Recent evidence shows that Ca2+-permeable AMPA receptors are involved in a variety of nervous diseases including amyotrophic lateral sclerosis (ALS) and allodynia. The JSTXs are potentially useful to understand pathogenesis of these diseases.


Abstract How is the craft history of ordinary woodcarvers different from the political and economic history of elites and literati? This article tells a transnational history of Ningbo miniature whitewood figurines that were first collected by Western travelers as souvenirs from the 1870s to 1940s and then shipped to the West as export craft from the 1950s to 1980s. The examination of the makers, buyers, and collectors of these figurines reveals a dialectic process between carving and collecting. Focusing on both the making and circulation of these figurines, the article uncovers a new layer in modern Chinese history: with the political regime changing from the imperial state to socialist state, the carving and business practices of local artisans continued at its own rhythm. Less than three and a half inches tall, Ningbo whitewood figurines represent a miniature China carved and consumed on a global scale during the long twentieth century.


Background: The study of diaphragm is considered a key point in the evaluation of COPD patients. Ultrasonography can be used for assessment of the site, structure and the motion of the diaphragm, assessment of excursion and thickness and diagnosis of paralyzed diaphragm. Subjects and methods: We conducted our work on 50 subjects, 40 COPD cases and 10 age and gender matched healthy control persons. They exposed to thorough history assessment, general and local chest examination, spirometric measurements (pre-and post-bronchodilators) including FEV1, FVC, FEV1/FVC, MVV, MIP and MEP then chest ultrasonography at different lung volumes was done. Results: MIP and MEP are decreased in COPD patients than control and with increasing grade of severity of the disease. Also, diaphragmatic thickness at different lung volumes (TDRV, TDFRC and TDTLC), diaphragmatic thickenings and excursion all are decreased in COPD than control. Highly significant positive correlation was found between diaphragmatic thickness at different lung volumes (TDRV, TDFRC and TDTLC), diaphragmatic thickenings and excursion with the spirometric finding as FEV1, MIP and MEP. Conclusion: US, MIP and MEP are non-invasive accurate methods in assessment of diaphragmatic function.


Abstract Endothelial cell tumors are the most common soft tissue tumors in infants. Tumor forming endothelial (EOMA) cells are able to escape cell death fate despite excessive nuclear oxidant burden. Our previous work recognized peri-nuclear Nox-4 as a key contributor to EOMA growth. The objective of this work was to characterize the mechanisms by which EOMA cells evade oxidant toxicity and thrive. In EOMA, compared to that in the cytosol, nuclear GSSG/GSH ratio was five-fold higher. Compared to those in healthy murine arterial endothelial cells (MAE), GSSG/GSH was over twice in EOMA in a situation. Multidrug resistance-associated protein-1 (MRP-1), an active GSSG efflux mechanism, showed two-fold increased activity in EOMA compared to MAE. Hyperactive YB-1 and Ape/Ref-1 were responsible for high MRP-1 expression in EOMA. Proximity ligand assay demonstrated MRP-1 and YB-1 binding. Such binding enabled the nuclear targeting of MRP-1 in EOMA in a leptomycin-B sensitive manner. MRP-1 inhibition as well as knockdown trapped nuclear GSSG causing cell death of EOMA. Disulfide loading of cells by inhibition of GSSG reductase (bischoloronitrosourea) or thioredoxin reductase (auranofin) was effective in causing EOMA death as well. In sum, EOMA cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells making it a potential target for EOMA therapeutics.


High density polyethylene (HDPE)/nylon6 (PA6) blends were prepared by means of melt extrusion and using ethylene – octane copolymer graft maleic anhydride (POE-g-MAH) as a reactive compatibilizer. Phase morphology, rheological and thermoresponsive shape memory properties of the blends had been studied. The results showed that addition of POE-g-MAH could increase compatibility and phase-interfacial adhesion between HDPE and PA6, decrease the temperature sensitivity of the melt, improve the shape memory property and processability of HDPE/PA6 blends. The shape recovery rate of HDPE/PA6/POE-g-MAH (80/20/10) blend is 96.5% when the stretch ratio is 75% and optimal shape recovery response temperature is 135°C.


Speculative realism's and object oriented ontology's [here we will mainly refer to Graham Harman's] projects are caught in a performative contradiction. They intend to reach a zero-person perspective ("the essence or intrinsic nature of any entity apart from any access we might have to it" (2005, p.253), but at least the author is anything but a person; they are dealing with the objects' essence, but the essence is always receding, and they do not want to stick to a form of negative ontology. Of course, Graham Harman is aware of this contradiction, and calls for oblique accesses to the objects' essence. However, we would like to examine the various performative strategies to sidestep this contradiction. 1/ One possibility would be to try to speak from the object, independently of human perception or frames. It is partly what Francis Ponge tries to accomplish in The Voice of Things. However, as Derrida clearly demonstrated, Ponge's texts are signed up, and if each text is singular, the singularity rather lies in Ponge than in the object itself. 2/ A second possibility, praised by Harman, is Alphonso Lingis's "carnal phenomenology", with whom we "encounter the lascivious warmth of the sun and air and the mastery of strange flashes at midnight" (Harman, 2005, p.2). This strategy appeals to how we contact the sensual world, the allures, and is therefore more adapted for sensual objects. However, of course, with Lingis human affectivity is central to the research endeavour. 3/ A third possibility might be indicated by Matthieu Brosseau's poetry. This French poet writes from the "central animal", and the "caction", "the conscience of the possibility of intertwining sutures, those which tie the acting silence with the holed absence of the passived self." Self is rendered passive to let "him as an object" write. However the perspective is of somewhere between the first and he third person, not the zero-person Harman is referring to. 4/ A fourth possibility would be Latour (2013)'s. By multiplying the modes of existence through which the object is described, each social-relational perspective is relativized. However, the objects is known through its effects inside the various modes' realms, not per se. The aim of this proposal is to propose a close look at Graham Harman's own strategy, in regard to the ones listed above. We will draw on his text about the Dutch East India Company (VOC) (Harman, 2016), which represents one of his very rare example of actually studying an object. He makes many moves in search of a zero-person perspective. For instance, he takes an object he has personally no direct contact with (the organization died more than 120 years ago). He did not really choose the object, the object was given to him by a text from Leibniz. In his depiction, he shows no personal affects or personal perspective. The human beings' actions, up to those of Governor-General Coen are deemphasized, in favor of the context and of symbioses, etc. But do we have a zero-person perspective on the object, or rather an author defending a very personal theory?


Abstract:This article focuses on how contemporary Dutch literature uses and produces images of and for Brussels. The stock of images the authors draw on consists of 'universal' images linked to urban literature on the one hand and specific images linked to Brussels in particular. Classic, modernist, and postmodernist urban images are all present in contemporary literature and are used in any combination. The stock of urban images and themes is increasingly being used in a conscious and creative way, to reflect upon the identity or identities of this city, rather than to preserve or establish them.


Aim: Arthroscopic visualization of the knee medial compartment can be challenging in tight knees and undesired chondral damage can occur during instrumentation in these cases. In order to achieve thorough examination of the medial meniscus and to avoid complications, pie crusting of medial collateral ligament (MCL) has been described, which provides opening of the medial joint space. However, concerns about over releasing and instability still remain. Moreover, the reliability and effectively of the piecrusting technique has not been studied widely. In this study, we aimed to investigate the advantages and possible complications of percutaneous releasing of medial collateral ligament in medial compartment arthroscopy. Material and Methods: A total of 320 arthroscopic surgeries performed between 2014 and 2017 were reviewed retrospectively and 28 patients who underwent partial meniscectomy or repair by pie crust technique were included in the study. Mean follow up was 18 (6-40) months. Patients were evaluated clinically with the Lysholm score and Tegner score. Additionally, joint balance, valgus instability, pain or tenderness at the MCL region and numbness at the medial side of the joint was noted. Results: On physical examination, during valgus stress at 30° of knee flexion, only one patient showed Grade 1 laxity; however, no patients had subjective valgus laxity at the final follow-up. Furthermore, there was no pain or tenderness over the MCL and there were no signs of saphenous nerve or vein injury in any of the patients. Conclusion: Pie-crusting of the medial collateral ligament is an effective and reliable technique which provides enough space for visualization and instrumentation of the medial compartment, particularly in tight knees.


Studies of public attitudes toward wolves tend to be descriptive in nature, and few sophisticated analyses of complex attitude patterns have been conducted. Drawing on findings from qualitative studies, the present study analyzed nationally representative survey data from Norway in order to probe the relationships between attitudes toward wolves and such factors as education, urban/rural place of residence, cultural capital, and various value orientations: environmental orientation, general political values, and trust in formal or informal information sources. Structural equation modeling confirmed that attitudes are embedded in more general cultural patterns. Although the cultural level is influenced by structural factors, effects of the background variables were reduced or disappeared in a model that included value orientations. This finding demonstrates that in order to access the level of meaning by means of survey methods, carefully constructed instruments and causal models must be employed.


A lipase from Aspergillus niger immobilized by adsorption on microporous, polypropylene hollow fibers was used to effect the hydrolysis of the glycerides of melted butterfat at 40°C and pH 7.0. Mcllvane buffer was pumped through the lumen and melted butterfat was pumped courrently through the shell side of a shell‐and‐tube reactor. Nonlinear regression methods were employed to determine the kinetic parameters of three nested rate expressions derived from a Ping Pong Bi Bi enzymatic mechanism coupled with three nested rate expressions for the thermal deactivation of the enzyme. For the reaction conditions used in this research, a four‐parameter rate expression (which includes a two‐parameter deactivation rate expression and a two‐parameter hydrolysis rate expression) is sufficient to model the overall release of free fatty acids from the triglycerides of butterfat as a function of space time and time elapsed after immobilization. At a space time of 3.7 h immediately after immobilization of lipase, 50% of the fatty acid residues esterified in the sn‐1,3 positions of the triglycerides can be released in the hollow‐fiber reactor.


Now that official Axis diplomats have been eliminated from Brazil following the Rio de Janeiro Conference, there remain three sources of possible subversive activities in that country: Axis nationals, Axis "racial comrades" of Brazilian citizenship, and general pro-fascist elements. In Southern Brazil, where 85% of the million Germanic settlers are Nazi sympathizers, is to be found the largest concentration of National Socialists in the world, outside Europe. Hitler's departing agents have left behind them a well-oiled machine, carefully trained to take over in case diplomatic relations were ever broken off. These states of Parana, Santa Catarina, and Rio Grande do Sul caused Brazil much anxiety during the first World War, but they had not then been systematically schooled in a technique of world-wide military domination which recent history has seen Axis sympathizers employing in Norway, Holland, France, and at Pearl Harbor. Wide rural areas and sizeable cities in South Brazil are German settled and controlled. Their key civic leaders-mayors and merchants, peasants, pastors and professional men-form possibly the major fifth-column organization remaining in South America's largest country. Some North Americans "discount" the potential danger of this area. There were North Americans, too, who spoke glibly of France's army as the greatest in the world and smiled at any suggestion that Pearl Harbor might be assaulted. The Brazilian settlements are not the only population centers for Axis propaganda and sabotage remaining in Latin America. Mexico's German groups have been skilfully drilled for Axis usefulness by a galaxy of Nazi agents during nine consecutive years. The pro-


Abstract The nucleoside triphosphate specificity of Escherichia coli succinic thiokinase (succinate:coenzyme A ligase (ADP), EC 220.127.116.11) was studied. The results showed that ATP, GTP and ITP (in decreasing order of effectiveness) were good substrates, while UTP and CTP were relatively ineffective. A nucleoside triphosphate ⇄ Pi exchange reaction stimulated by succinate and CoA was observed with each nucleoside triphosphate tested. A nucleoside diphosphate kinase activity of the enzyme was observed and found to be different from the ubiquitous nucleoside diphosphate kinase (ATP:nucleoside diphosphate phosphotransferase, EC 220.127.116.11) in its substrate specificity and its marked tendency to be stimulated by succinyl-CoA. Thus, with ATP as the phosphoryl group donor, GDP and IDP were good acceptors, UDP was a relatively poor acceptor, and CDP exhibited almost negligible activity in this respect. The nucleoside diphosphate kinase activity of succinic thiokinase was inhibited at ATP concentrations in excess of 0.5 mm. A comparison of the NDP-kinase to thiokinase activity ratio has revealed that the NDP-kinase activity does not represent a minor catalytic capability of the enzyme.


Objective To analyze the factors which influenced medication compliance of patients with chronic hepatitis B(CHB),so as to improve the treatment compliance of patients.Methods 32 patients with poor compliance were recruited as the observation group,32 patients with good compliance were selected as the control group.The multivariate logistic regression model was used to investigate the potential correlative factors that influenced the medication compliance of the case.Results Compared with poor medication compliance of patients,the good medication compliance of patients,who had family history of hepatitis B (OR 0.042,95% CI 0.005-0.333),learned more about the content of the antiviral treatment (OR 0.112,95% CI 0.014-0.872),and got more information from physicians (OR 0.142,95% CI 0.020-0.993),showed poor compliance risk reduction.Conclusions The patients who had family history of hepatitis B can gain more message from the relative experience of treatment.Their medication compliance were better.Future work should focus on health education to improve the compliance of patients receiving antiviral therapy.

Key words:
Chronic viral hepatitis B;  Antiviral therapy;  Treatment of cognition;  Compliance


In this paper the synthetic methods of alpha-aryl-beta-nitroalkyl phenyl phosphinothionates 4 which were unknown were studied in detail and it was found that only when using Lawesson's reagent (LR) as thionating agent these compounds were obtained in high yields. The configuration of 4 was determined through the analysis of high resolution H-1, (31)PNMR and X-ray diffraction. With the help of investigation of plausible mechanism, the stereochemistry of LR thionating the P=O group was studied. So far this is the first detailed report as to the mechanism and stereochemistry of sulfurization of compounds involving the P=O group with LR.


Integrated Marketing Communications are composed of ads, sales promotion, personal sale, direct sale and public relations. The main challenges in Integrated Marketing Communications are the recognition of communication means of mixed marketing, the advantages of International Advertising, the methods of determining promotional budgets, the steps in developing an effective communication of marketing. Integrated Marketing Communications are means with which the firms try to remind the consumers about their products and services. A very important challenge is the measurement of marketing's results and the analysis about what percent of these costs are reversed or have exceeded beyond the margin of spending. The firms have to invest more in Integrated Marketing Communications, where the importance of investments is seen from two points of view: the growth of profit and their role towards the public. International advertisements have a great impact in introducing the products and services in international markets. The costs of international ads have changed depending on the periods of economic development; the periods of global developments are associated with the increase of advertisements costs, while the periods of global recessions are associated with the decrease of these costs. In this paper it is explained how the importance of marketing's integrated communications affects the growth of sales and the connection with the public and the role of international ads in promoting new products in international markets. The first part of the paper is composed of reviewing the adequate literature and the second part has to do with the part of the study about Integrated Marketing Communications and international advertisements. Primarily data was realized through questionnaires, through direct contact with marketing managers, general managers, owners and directors of companies that have sufficient knowledge about their companies. DOI: 10.5901/ajis.2015.v4n1s2p115


Tracer atoms have been used to develop a quantitative method for the determination of the emulsifier content of latex films. A set of styre-acrylate latexes with different polymer rigidities have been prepared, containing sodium dodecyl sulfate with labeled sulfur. Investigation of the film formation from latexes by drying in air and by electrodeposition on a copper anode has shown that at a given emulsifier concentration in the latex, its contents in the film differ noticeably, depending on the method of preparation, and in the case of electrodeposition on the polymer properties. The structure of the electrophoretic film can be assessed from its emulsifier content.