A PK/TE model was established via simultaneous fitting of total CNTO-X, total IL-6 and free IL-6 profiles following a low dose of CNTO-X. The model well captured the observed data and provided estimation of key model parameters with good precision. The PK/TE model was used to predict free IL-6 profiles at higher CNTO-X doses, where accurate determination of free IL-6 became technically too difficult. The measured free IL-6 levels from the low dose groups and PK/TE modelpredicted free IL-6 levels from the high dose groups were used to drive the TE/PD model. The indirect response TE/PD model well captured both CRP elevation and CRP lowering in response to free IL-6 level changes from baseline with a simple linear stimulation function. Conclusion Our results suggest that an integrated bioanalytical and PK/TE/PD modeling approach may be useful to predict efficacious doses and duration of action for mAbs targeting rapid turnover soluble ligands. This proposed theoretical framework may be broadly applicable to the development of mAbs against rapid turnover soluble targets. Encore presentation-- first presented at the ACCP Annual Meeting, Sept 22-24, 2013.


The functions of many eukaryotic genes are still poorly understood. We developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Module Association Determination (G-MAD) allows the annotation of gene function. Second, Module-Module Association Determination (M-MAD) allows predicting connectivity among modules. We applied the GeneBridge tools to large-scale multi-species expression compendia—1,700 datasets with over 300,000 samples from human, mouse, rat, fly, worm, and yeast—collected in this study. Unlike most existing bioinformatics tools, GeneBridge exploits both positive and negative gene/module-module associations. We constructed association networks, such as those bridging mitochondria and proteasome, mitochondria and histone demethylation, as well as ribosomes and lipid biosynthesis. The GeneBridge tools together with the expression compendia are available at systems-genetics.org, to facilitate the identification of connections linking genes, modules, phenotypes, and diseases.


Nowadays, hospital wastes are dangerous for human health in developing countries. Construction waste is becoming a serious environmental problem in many large cities in the world (Chen et al., 2002). Hospital wastes because of its production nature usually have high potential to damage environment. Minimization in production process of hospital wastes can decrease wastes and it has economical profits. Goal of this study to find methods to minimize the special hospital wastes, therefore we introduce different part of a pilot hospital (Akbar Abadi hospital) and checking statics status produce and segregation stages for special wastes. After doing research, biochemical laboratory part because of having sn and solphore compounds in wastes of consumed kit is important part of hospital for minimize special hospital wastes. By changing technology and usage of new equipment (Ecom and Auto analyzer) in biochemical laboratory producing special wastes caused by using kit like sugar, cholesterol, Triglyceride, Ore, Uric acid, SGOT-SGPT-ALKP, Calcium and Phosphorus ,can be minimize equal to 55 and 83 liters wastes in a year. In hormonology laboratory with use of automatic washer, amount of produce wastes equal to 19,800gr in year.


This study examined the factors influencing the intention of agribusinesses to start up dairy related business in Pakistan. Using both the "Entrepreneurial Event Model" and "Determinants of Entrepreneurial Intentions" model, an integrative model is proposed and tested using survey data collected from 174 entrepreneurs in Pakistan's dairy industry. Results of partial least square structural equation modelling show entrepreneurial intentions are positively influenced by perceived desirability, perceived feasibility, perceived readiness, triggering event, and individual's conviction. However, the effects of perceived feasibility and conviction were found more significant and substantially related to intentions. Theoretical and practical implications of these findings are discussed in the context of agricultural industries in developing countries like Pakistan's dairy industry.


The invention relates to a single-shoe manufacturing method, which comprises the following steps of: (1) putting a steel band on a rolling machine, rolling the steel band until the section of the steel band is U-shaped through rollers of dozens of molding dies, and screwing the rolled material with the U-shaped section into a helix; and (2), putting the treated helical material with the U-shaped section on a cutting machine for cutting section by section, wherein the cutting mode is that the helical material is cut at every circle sequentially. According to the single-shoe manufacturing method, the problems of unstable size, time consumption and the like caused by the conventional method for producing early profile of a single shoe are solved; the process of rolling and rotating and the process of cutting are separated, so that the size consistency and the qualified rate of a C-shaped profile are improved; the cost and the maintenance cost of the die are reduced; and the working efficiency is greatly improved.


over its inner surface, we can feel no surprise that such great talents should have been devoted to investigate the curious properties of the one, or that the structure of the other should have been examined with so much assiduity. The keenness of inquiry manifested by the cultivators of anatomy, in observing the most minute parts that have escaped the notice of their predecessors, shows that any addition to the common stock of our information on this subject will be gratifying to a certain portion of the members of this Society, and probably not uninteresting to the Society at large. It is not my object, in the present paper, to examine either the first effect of the cornea in rendering the rays of light convergent, or the power of the crystalline lens in finally bringing them to a focus on the retina. It is not my intention to investigate whether the adaptation of the eye to different distances is effected bv alteration of the form of the lens from its own muscular structure, or by alteration of its place, from the agency of other muscles. Nor do I mean to consider either the involuntary motions of the iris dependent on the quantity of light present, or that voluntary contraction of it by which we adapt the aperture of the pupil for distinct vision at diffeient distances, limiting thereby, what in optics is termed the spherical aberration ot the lens. The subject of my inquiry relates solely to the course by which impressions from images perfectly formed are conveyed to the sensorium, and to that structure and distribution of the optic nerves on which the


The author makes an attempt to call the attention of city philosophical society to the subject of place and role of philosophy in modern global world. Paradoxicality of modern situation is that nobody challenges against fundamental role of philosophy in education and upbringing of the younger generation, but Russian state educational policy brings this role to nothing. In author's opinion society's requirement in philosophy stands among main vital requirements


This paper makes an analysis of social background from the economical, cultural and hi-tech perspective, against which technical secondary schools have been promoted to high vocational schools. The new situation has put forward new demands on vocational education through the comprehensive and profound impacts of the transformation from planned economy to market economy on the admission system, training goals and specialties; through the impacts of the changes in cultural concepts and environment on removing traditional cultural views and on school administrative modes; and through the impact of the fast development of science and technology on the life-long vocational education.


The present review is an attempt to characterize the principles of both onset and development of the systemic antitumor immune response triggered by in situ vaccination, which is a new trend in anticancer immunotherapy. Modern methods of cancer immunotherapy usually require the presence of a specific target antigen. The in situ vaccination approach does not need a specific antigen. The determinants necessary for the formation of the immune response are all present at the vaccination site, as tumor cells are lysed by cells of innate immunity, infiltrating the tumor and activated by the treatments. The first part of the review is a compilation of the literature data on causes, circumstances, and factors determining the presence in the local tumor node of the totality of tumor antigens essential for the development of the adaptive antitumor immune response. The second part of the review analyzes possible events of antitumor immune response development due to in situ vaccination using ligand-receptor interaction and antigen-presenting cells activation, based on the data structuring performed previously


(1999) Arch Intern Med 159, 1710. George MR, O'Dowd LC, Martin I . , et al. . A comprehensive educational program improves clinical outcome measures in inner-city patients with asthma. . Aug 9/23; . : . –6 .

[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4]

 QUESTION: Does a comprehensive educational programme improve outpatient follow up and decrease subsequent hospital admissions in inner city patients with acute asthma?

Randomised (allocation concealed), unblinded, controlled trial with 6 months of follow up.

A university hospital in Philadelphia, Pennsylvania, USA.

77 patients between 18 and 45 years of age (mean age 29 y, 79% women) who were admitted from the emergency department (ED) with acute asthma and who lived in the inner city. Exclusion criteria were comorbid disease, inability to speak English, lack of telephone access, or pregnancy. Follow up was 100%.

44 patients were allocated to an educational programme including inpatient asthma education by an asthma nurse specialist, bedside spirometry, discharge planning assistance, a telephone call 24 hours after discharge, and scheduled outpatient follow up within 1 week of discharge (intervention group). 33 …

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In Understanding and Treating Fear of Pain, the authors identify and discuss how pain-related fear and anxiety can lead to chronic pain even after healing of tissue damage has occurred. This fear can produce avoidance behaviour that, over time, leads to deconditioning, decreased mobility, further pain experiences, negative expectancies, and reinforced avoidance. This information is crucial to our measurement and management of ongoing pain-related disability, especially when objective findings do not support the disability observed. This book is well organized, with 15 chapters divided into 4 major sections.

Section 1 (Chapters 1–7) examines theoretical foundations and empirical findings on fear avoidance and its relation to chronic pain. An overview of models was used to explain chronic pain and fear and anxiety are identified as the major factors leading to avoidance behaviour. The authors suggest that anxiety precipitates cognitive scanning of symptoms, which leads to increased physiologic autonomic arousal, motivating individuals to prevent painful or perceived painful situations. These factors may explain the maintenance of disability in chronic pain after tissue healing has occurred.

Arguments are presented to suggest that pain-related fear and subsequent avoidance are conditioned phenomena or learned behaviours. A behavioural analysis of pain-related fear identifies primary (fear of pain) and secondary (social and emotional) factors that influence behaviour. These behaviours, in turn, have consequences for the client, including reduced responsibilities, a diminished sense of achievement, disturbed social relations, and discouragement of social contacts.

The concept of hypervigilance is used to explain high symptom reporting when symptoms are medically unexplained. The hypervigilant person constantly scans their body looking for pain and may misinterpret normal somatic sensations as pathological. Hypervigilance appears to be related to high anxiety and other emotional factors, including negative affectivity and catastrophizing. High levels of anxiety sensitivity may lead individuals to interpret normal somatic sensations as harmful.

The second section (Chapters 8–11) examines assessment. Assessment of fear-avoidance beliefs should encompass the object of fear and how it interrupts the individual's identity. This information can then be used to educate the person with chronic pain.

Fear and anxiety related to pain must be examined using motor, physiological, and cognitive activity measures. Cognitive activity is measured with self-report questionnaires, such as the Fear-Avoidance Beliefs Questionnaire (FABQ), the Fear of Pain Questionnaire-III (FPQ-III), the Pain Anxiety Symptoms Scale (PASS), and the Tampa Scale of Kinesiophobia (TSK). Physiologic measures may include electromyographs (EMG) and cardiovascular tests, as well as electroencephalographs (EEG). Motor measures include assessing facial features and measuring physical impairment/disability, as in functional capacity evaluations (FCE).

Much of the research suggests that fear avoidance is the strongest predictor of disability and function, stronger than intensity of pain. Early identification of fear and anxiety is important for treatment, because at-risk patients will likely not improve with medical care and/or physical therapy.

Patient–therapist relationships are crucial in working with fearful-avoidant clients, as these patients are trying to find biomedical answers and may not be open to treatment based on a bio-psychosocial approach. A goal of treatment is to educate and to encourage a change of belief "that all pain means harm." Collaborative goal setting, highlighting client self-efficacy, and practising empathy in difficult situations are identified as key to building a strong therapeutic relationship.

The third section (Chapters 12–14) discusses treatment. In the primary-care setting, assessing and treating psychosocial factors may be difficult. Many primary practitioners, including physical therapists, hold and encourage fear-avoidance behaviour. Furthermore, the research suggested that the more we approach pain from a biomechanical perspective, the more likely we are to encourage rest. Methods suggested as helpful in the primary-care setting are explaining examination findings and encouraging resumption of regular activity as soon as possible. Education on hurt versus harm is also advocated.

Cognitive-behavioural therapy (CBT) for treatment of fear and avoidance is identified as helpful. The authors suggest that CBT may not treat pain directly but can reduce the fear, anxiety, and depression associated with chronic pain.

The most promising aspect of treatment presented is in vivo exposure, a technique to produce systematic disconfirmations between expectations of pain and harm. The premise of exposure therapy is that persons with chronic pain tend to overestimate how intense their pain will be with action but, after being exposed, will correctly match predictions with actual experience. Research on in vivo exposure has been very supportive of this form of treatment.

Chapter 15, which constitutes the final section of the book, addresses future challenges and research directions. Some interesting ideas are discussed, including the question of whether or not there is a genetic predisposition to chronic pain. For example, anxiety may be a heritable trait causing dysregulations of serotinergic or gabanergic systems.

Understanding and Treating Fear of Pain presents a new understanding of chronic pain and promising new treatment approaches and would benefit those working in primary-care or chronic pain settings.


It is very difficult to estimate the relative arrival delay of the eigenrays for an unknown source in shallow water. The effects of a source position changing in the neighborhood and sound speed profile perturbation on arrival time of eigenvays are similar. In this paper, we present a robust localization method based on the auto-correlation function of wide-band signal of single hydrophone. By designing neighboring location constraints, a weighting function is constructed to change the peak cross-interference of the auto-correlation function to useful information that is conducible to the improving of targeting performance. In this method there is no need to estimate the relative arrival delay of the eigenray. Computer simulation shows that the robust method can achieve better localization performance, and even has tolerences of environment mismatch and searching grid mismatch. The performance of the robust method is validated through the broad-band data collected on a vertical line array during the Shallow Water 2006 experiments.


This paper presents a dynamic routing method for shortest path planning and conflict prevention of AGV system, and then illustrates the principle and implementation of this method. It gives a way to schedule a shortest and conflict-free route by utilizing Dijkstra algorithm and the Dynamic Time-Window Method, and comes to the conclusion by experiments that the combination of these algorithms will solve the routing problem of small-sized multi-AGV system to a large extent.


Abstract : The purpose of this study is to evaluate the influence of U. S. Naval leaders on American foreign policy and strategy in China during the Civil War, 1945-1950. Various stages of American foreign policy toward China helped the Nationalists re-occupy the country after Japan's surrender; the U. S. tried to mediate the Nationalist/Communist Civil War; the adoption of a non-involvement policy in the conflict; and then, after the Nationalists fled to Taiwan, Americans were divided over the issue of aid to the Taipei regime. Though postwar chiefs of naval operations were fearful of war with Russia they realized that a Communist victory in the Civil War would improve the geopolitical position of Russia. By contrast, U. S. Naval commanders in China favored large scale American aid to the Nationalists. (Author)


At temperatures below −40 °C the proton magnetic resonance of α,α,2,4,6-pentachlorotoluene in toluene-d8 or methylcyclohexane is an ABX spectrum where X is the methine proton. The C—H bond of the dichloromethyl group lies in the plane of the ring and its proton couples to one ring proton only. As the temperature increases the mean lifetime before interconversion of the "mirror image" isomers decreases and at 70 °C the proton spectrum is A2X. A density matrix formalism is used to calculate the line shape as a function of the lifetime before exchange. The free energy barrier to rotation of the dichloromethyl group is 15.0 ± 0.1 kcal/mole in both solvents. In toluene-d8 the entropy of activation is near zero. The high energy transition state is very likely one in which the C—Cl bonds of the ring and the dichloromethyl groups are eclipsed.


Background: Ewing Sarcoma (ES) is a primitive sarcoma defined by EWSR1–ETS fusions as the primary driver alteration. To expand our understanding of the genetic and molecular characterization of ES, we conducted a comprehensive analysis of clinical genomic profiling data on tumors from 113 patients using the MSK-IMPACT platform (Integrated Mutation Profiling of Actionable Cancer Targets). Methods: The dataset consisted of ES patients prospectively tested with the FDA-cleared MSK-IMPACT large panel, hybrid capture-based NGS assay. To assess the functional significance of ERF loss, we generated ES cell lines with increased expression of ERF as well as lines with knockdown of ERF. We assessed cell viability, clonogenic growth, and motility and performed transcriptomic and epigenetic analyses. Finally, we validated our findings in vivo using cell line xenografts. Results: Unlike previous ES genomic cohorts, ours included more adult patients (>18 years of age) and more patients with advanced stage at presentation. TP53, STAG2, and CDKN2A were the most common alterations and were associated with worse overall survival at 5-years. Notably, 3% had activating FGFR1 alterations (1 amplification and 2 hotspot activating kinase domain mutations). Mining data generated using a targeted RNAseq assay that includes FGFR1 based on the Archer Anchored Multiplex PCR technology, FGFR1 was highly expressed in the ES cohort (N=42). The 2 patients with activating FGFR1 mutations had relatively high expression of FGFR1. The second novel subset of patients in our cohort were defined by recurrent secondary alterations in ERF, which encodes an ETS domain transcriptional repressor, in 7% of patients (5 truncating mutations, 1 deep deletion, 2 missense mutations). ERF alterations were non-overlapping with STAG2 alterations, suggesting a potentially important biologic role in ES. As the functional significance of FGFR1 mutation in ES has been previously studied, we focused our functional studies on the role of ERF status in ES. In vitro, increased expression of ERF decreased tumor cell growth, colony formation, and motility in two ES cell lines, while ERF loss induced cellular proliferation and clonogenic growth. Transcriptomic analysis of cell lines with ERF loss revealed increased expression of genes and pathways associated with aggressive tumor biology, and epigenetic, chromatin-based studies revealed that ERF competes with EWSR1-FLI1 at ETS binding sites. Conclusion: Our study reveals a previously unexplored role of ERF loss-of-function in ES. Older age in our cohort, and a higher proportion of patients with advanced disease at presentation, could potentially explain the finding of ERF alterations which were associated with aggressive tumor biology in our preclinical studies. Our functional analyses of how ERF modulates EWSR1-FLI1 oncogenicity may open a new window into the pathobiology of ES. Moreover, our data suggest that 3% of ES patients harbor activating FGFR1 mutations, the first targetable kinase alteration in this sarcoma.
 Citation Format: Arielle Elkrief, Koichi Ogura, Anita S. Bowman, Richard P. Koche, Ryma Benayed, Audrey Mauguen, Marissa S. Mattar, Inna Khodos, Elisa de Stanchina, Paul A. Meyers, John H. Healey, William D. Tap, Neerav Shukla, Meera Hameed, Ahmet Zehir, Charles Sawyers, Rohit Bose, Emily Slotkin, Marc Ladanyi. Prospective clinical genomic profiling of ewing sarcoma: ERF and FGFR1 mutations as recurrent secondary alterations of potential biological and therapeutic relevance [abstract]. In: Proceedings of the AACR Special Conference: Sarcomas; 2022 May 9-12; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(18_Suppl):Abstract nr B023.


In a context that sums up the syntagm of the survey, the place of Ortigia, an historical archive of building and summation of harmonious sensory effects, should be seen as an urban aggregation without boundaries, substantially not enclosed by the skyline and open to a rapport with the sea. The methodological approach of the study undertaken tackles the issue of managing information that is highly interrelated, referring to the entire monumental unicum , by means of recognition of the parts, at times also fragmentary. The research is articulated within a coherent frame of interactive readings, the outcome of responsible working choices of surveying and graphic rendering, always verifiable and adaptable to the specific qualities of the site. In this paper, the results related to a place of particular fascination and importance, namely the Cathedral square of Ortigia, are reported.


COPYRIGHT © 2023 Durcan and Axtman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: The next generation of tools and technologies for studying human neurons in a dish


Sub Saharan African economies are increasingly dependent on small businesses in the informal sector. Subsequently, there are many institutions established with the aim to support small businesses a ...


In order to identify the risk of the letter and visit stability work, on the basis of summarizing the existing research methods, put forward a scheme for the monitoring and risk identification of the letter and visit information based on the big data of the Internet. Firstly, through real-time network crawler and other means to establish the labor relations field letter information monitoring data set, then based on data mining technology, relying on the network big data to carry out risk identification research on the letter and visit information, and finally based on the letter and visit information monitoring and risk identification results put forward a preventive mechanism.


With the rapid growth and enhanced aim of wind power,large scale development of wind power has become an inevitable trend.To guarantee the reliable and effective transmission of wind power,economic analysis is investigated based on the development conditions and transmission of wind power in our country.The selection of technical parameters and its impact on the economy are analyzed by the means of price competitiveness analysis for UHVDC transmission combined with wind and thermal power.It is shown that the wind power transmitted by UHVDC is economically feasible,and some related suggestions put forward.


ABSTRACT Foxtail (Alopecurus aequalis) and milk vetch (Astragalus sinicus) are typical winter weeds grown in single-cropping rice fields during the fallow season in central Japan. These winter weeds are generally incorporated into the soil as green manure during plowing, and before rice transplanting, to improve soil fertility and rice yield. To understand the carbon (C) decomposition and nitrogen (N) mineralization behavior of fallow weeds in organic rice farming, we carried out two experiments. Firstly, we examined the effect of adding 1% foxtail to soils that were sampled from fields that were farmed conventionally or organically for different durations (4–12 years). The results showed that net N mineralization of incorporated foxtail was not affected by the duration of organic farming, although the N mineralization of indigenous soil increased with organic farming duration. Secondly, 1% pulverized young and old foxtail (YF and OF; C/N ratios of 47.0 and 54.9, respectively), and milk vetch (YM and OM; C/N ratios of 13.0 and 14.6, respectively), were mixed with soil samples from fields that had been farmed organically for 15 years to determine the role of each plant. More than half of weed C was decomposed during 4 weeks of anaerobic incubation at 30°C. In addition, the net weed C decomposition potentials were significantly higher in YF and YM than those in OF and OM. The lower C/N ratio of milk vetch was contributed to a net N mineralization rate that was 8.4 times higher than that of foxtail. The percentage of N mineralized from milk vetch was significantly higher (about 2.3 times) than that from foxtail. Even though foxtail incorporation can contribute to the growth of organic rice as an N nutrient source, it should be noted that net N immobilization occurred for 2 weeks of incubation at 30°C, and sometimes extended to 4 weeks before net N mineralization became tangible. Considering this early net N immobilization following incorporation of foxtail, it is recommended to wait at least 4 weeks between the start of flooding after weed incorporation and transplanting rice to facilitate initial growth and avoid N exhaustion.


1MONG the Swedish poets usually associated with the 1940's Werner jt'_ Aspenstrom holds a central position; yet he is overshadowed in the popular mind by the two poets who are recognized as the leaders of the movement insofar as it can be called a movement: Erik Lindegren and Karl Vennberg. In the magazine called 40-tal (The Forties) he played an important part, and he was on the advisory board of Prisma, that magazine devoted to the arts and edited by Erik Lindegren which was so excellent that it could only keep going for three years in the cultural climate of Sweden.


This paper introduces some improvement measures of slurry pipe jacking construction.The practices show no accidents are occurred and 18 days ahead the anticipation date after improvement.


The importance of corn production to the midwestern United States cannot be overestimated. However, high production requires high nitrogen fertilization, which carries costs to environmental services such as water quality. Therefore, a trade-off exists between the production of corn yield and water quality. We used the Groundwater Vulnerability Assessment for Shallow depths and Crop Environment Resource Synthesis-Maize models to investigate the nature of this trade-off while testing the Simple Analytic Framework trade-offs featured in this Special Feature. First, we estimated the current levels of yield and water quality production in northeastern Iowa and southern Minnesota at the 1-square-kilometer, county, and regional scales. We then constructed an efficiency frontier from optimized nitrogen application patterns to maximize the production of both yield and water quality. Results highlight the context dependency of this trade-off, but show room for increasing the production of both services to the benefit of all stakeholders. We discuss these results in the context of spatial scale, biophysical limitations to the production of services, and stakeholder outcomes given disparate power balances and biophysical contexts.


Improving performance in detection systems is one important challenge in dealing with terrorism and insurgencies. Terrorist activities are based on covert operations and make use of deception to hide intent and possible detection before action occurs. The intelligence community and law enforcement personnel struggle to improve detection systems to counter activities of terrorists and insurgents across the world. In the decision sciences and learning disciplines, most notably in the cases of cyber threats and attacks, selection‐detection processes have been studied as part of an effort to increase the accumulated knowledge of how to detect those elements that belong to a distribution of interest (signal) when such elements are embedded in a larger population of elements that are not of interest (noise).


As Dr Messas et al point out in their letter about our article,1 surgeons should attempt to restore function when addressing mitral regurgitation. The mitral valve is complex, and more than 1 cause of mitral regurgitation can be present at any one time. Carpentier's classification was revolutionary because it was the first functional classification that truly allowed surgeons to identify and use repair techniques that would render the valve competent independently from the pathogenesis of the regurgitation.

Carpentier …


What did the Olympics tell us about ourselves, our society's values and its possibilities? in this new collection of critical reflections on the Games, contributors imaginatively address the reality of their impact. They question what the ceremonies and Team GB represented; explore the meanings and experience of 2012's summer of sport for both participants and spectators; and interrogate the organizers claims of economic regeneration, sustainability and boosting participation. This is an essential and exciting read for all who understand and appreciate that London 2012 meant something - but are unsure what. Contributors include world-class experts in Olympism, writers and journalists who reported on and were inspired by the Games, social and cultural critics, sports policy consultants and sport campaigners.


According to the requirements of test methodology in"GB / T 19826-2005 General specification and safety requirements for DC power supply equipment of power project",an evaluative parameter test system for DC power supply equipment of power project is designed,which consists of electrical parameter measuring and control instrument,program control resistive load,digital oscilloscope and supervisory computer.The supervisory carries out the control of DC power supply and battery test and issues the test report.The CS5460A is used to measure DC voltage and current.The load controller designed with UC3875 ZVS(Zero Voltage Switch) PWM realizes the program-controlled resistive load.The ripple is tested by the 20 MHz wideband digital oscilloscope with the isolated DC filter circuit.Practical results show the design efficient and reliable,meeting the test requirements.


In this contribution, a discretisation of the IBC EFIE is introduced that (i) yields the correct solution at arbitrarily small frequencies, (ii) requires for its solution a number of matrix vector products bounded as the frequency tends to zero and as the mesh density increases. The low frequency stabilisation is based on a projector-based discrete Helmholtz splitting, rescaling, and recombination that depends on the low frequency behaviour of both the EFIE operator and the surface impedance condition. The dense mesh stabilisation is a modifcation of the Perfect Electric Conductor operator preconditioning approach taking into account the effect on the singular value spectrum of the IBC term.


The aim is to look back at all the steps that led to the creation of the institutional and legal framework of the PPP. Suggestions and thoughts to make the PPP mode more orderly and beneficial for both sides Public - Private.


Abstract:Aḥmad Ibn ʿAjība (d. 1224/1809) was one of the most prominent Sufis who lived in Morocco during the 13th/18th century and transmitted the teachings of the school of Ibn ʿArabī (d. 638/1240), while being affiliated to the Shādhilī Darqawī Sufi order. His importance in Sufi scholarship is a reflection of the fact that he was an original thinker who contributed extensively to elucidating ambiguous Sufi concepts that were, by their very nature, enigmatic and only accessible through Sufi adepts. His primary area of expertise was Quranic esoteric hermeneutics because he was one of the few scholars who managed to convey theoretical concepts and esoteric theories of Quranic interpretation in a language that could be accessed by the general public, and to this end he penned an influential Quranic exegesis. One of these esoteric theories on which he wrote, and which is a central feature of Sufi thought and hermeneutics, is the concept of divine love.


A compact dual-passband three-dimensional (3D) frequency selective surface (FSS) is proposed based on multiple square coaxial waveguides (SCWs), which exhibits good angular stability and both-side fast roll-off characteristics. The unit cell of the proposed 3D FSS is composed of one parallel plate waveguide (PPW) propagation path and two SCW propagation paths. By etching a centered annular slot, each SCW path forms two identical short SCWs. Each short SCW inherently generates one square slot resonance. In each SCW path, on the account of electromagnetic coupling between two square slot resonators provided by two short SCWs, the square slot resonant mode will split into even-/odd-resonant modes. Accordingly, each SCW path can provide a flat second-order passband with two transmission poles. Due to the reflection and out of phase of electromagnetic waves, four transmission zeros located at both sides of the passbands are introduced for high frequency selectivity, realizing both-side fast roll-off performances. In order to explain the operating principle, the electric-field distributions at transmission-zero/pole frequencies are investigated. Finally, an FSS prototype is fabricated and measured, and the results exhibit good angular stability for both TE and TM polarizations under incident angles from 0° to 60°. In addition, the proposed 3D FSS
has a compact unit cell.


Objective: To compare the influence of haemodynamic and hormonic responses to induction and endotracheal intubation with propofol, thiopental and etomidate. Methods: 30 patients were divided randomly into three groups ( n =10). Anesthesia was induced with either propofol 2mg/kg ( groupⅠ), thiopental 5mg/kg ( groupⅡ) or etomidate 0.3mg/kg ( groupⅢ), together with fentanyl 3μg/kg and vecuronium 0.1mg/kg for endotracheal intubation. Results: The HR of group I was decreased (P0.05) after induction , the groups Ⅱ and III heart rate were increased significantly during the intubation, (P0.05 ). The MAP of group Ⅰ was decreased after induction, ( P0.05 ). The group Ⅱ MAP had decreased after induction and increased during and after 4min intubation, ( P0.05 ). The group Ⅲ MAP was increased during intubation, ( P0.05 ). In groups Ⅱ and Ⅲ, both cortisol and insulin were increased obviously after intubation for 4 min, (P0.05) In all the three groups, the blood sugar was not significantly increased after intubation, ( P0.05). Conclusion: Haemodynamic and hormonic responses are less in propofol group than in thiopental and etomidate group during induction and intubation and it is useful for anesthesia to do the induction with propofol.


In recent years, political journalists have taken seriously the notion that we have entered a new era of politics in which large numbers of young people, disaffected from the old mass media, have become far more susceptible to the internet and the new social media. We are supposedly witnessing a mass mobilisation of grassroots politics among the young. Kevin 07 and Obama 08 are said to have capitalised on this phenomenon and mastered its techniques for defining issues, generating support and raising vast sums of money.


Triple probes are often exposed to the outer layers of fusion devices as well as to other plasmas, mainly to make use of the better time resolution if compared with ramped single probes. But this type of probe puts its tips on fixed potentials with respect to the floating potential and, therefore, the evaluation of plasma parameters must rely on a certain functional structure of the underlying current-voltage characteristic. Furthermore, the interpretation of triple probe measurements is usually based on the assumption that all three tips are exposed to the same plasma. If this is not the case (as expected for strong gradients) or if the characteristics are distorted from the assumed form (as in strongly magnetized plasmas) the parameters derived are no longer what they are supposed to be. Several typical deviations from the simple interpretation of triple results are discussed, indicators for a malfunction are identified, and corrections are proposed, at least for some cases.


Summary The ability of essential and nonessential amino acids to stimulate the release of CCK was investigated in dogs using a bioassay procedure based on the perfusion of duodenojejunal Thiry-Vella loops and determining the increase of pancreatic protein response as well as the potentiation of pancreatic bicarbonate secretion induced by a background dose of secretin (0.2 units/kg/hr). All essential amino acids except threonine and all nonessential amino acids except cysteine and aspartic acid were effective in CCK release when perfused in equimolar concentration (50 mM) through the intestinal loop. The highest activity for release of CCK was exhibited by tryptophan and phenylalanine, which were also shown to release small amounts of secretin. The peak pancreatic protein response to tryptophan was 80% of the maximal response to exogenous CCK (25 units/kg/hr).


Ethylene-co-vinyl acetate copolymers are gel-free, randon copolyners postents from 40 to 80 percent. They are categorized as EE materials (ASTM D-2000) possesing up to 175°C, ozone, weathering and oil resistance. The promineoce of EVM as a molded part (gasket or seal) is increasing in the automotive/heavy truck industry. The first part of this treatise investgates the use of EVM for bonded piston seal automotive transmissions by evaluation in the latest generation of automatic transmission fluids. The second part deals with its use for a heavy duty gasket application for diesel enginse using oil formulated to PC 10 guidelines.


A multivariate cumulative sum (MCUSUM) control chart is one type of multivariate control chart for monitoring the mean vector. A multivariate normal distribution is an important assumption that is used to describe a behavior of a set of quality characteristics of interest. This research explores the sensitivity of ARLs and SDRLs when the MVN assumption is incorrect. ARLs and SDRLs for data from multivariate t, uniform, beta, and lognormal distributions are estimated and compared to ARLs and SDRLs under the MVN assumption. The ratios of SDRL/ARL are also computed to consider a relationship between ARL and SDRL. ______________________________


In recent years, there has been increasing public concern about the health implication of electromagnetic (EM) wave exposures due to the electronic sources.  For this reason, various public organizations in the world have been established safety guidelines. This paper focused on the investigation of Marmara University students' health effects that cause by the radio frequency (RF) sources. For the purpose of the assessment, electric field strength values are measured at 44 different location points of Marmara University in Goztepe Campus. In addition to the spot measurements, 24 hours measurement is also done to analyze the variation of electric field strength values. The results show that the measured electric field strength values are below the recommended international standard limits.


Once the spacecraft are launched, it is almost impossible to bring back and repair them again. At this point of view, the AIT (Assembly, Integration and Test) on the ground before launch is very important for all of space programs. Usually, it takes several years and more for thorough examinations because it totally depends on the complexity of the space program. In today"s environment, as demands of cost effective and reliable spacecraft increase, there have been a lot of researches supporting it. Removal of duplicated work, design of efficient test procedure and re-use of test equipments can be good examples. This paper is aimed at describing the recent trends and technologies about electrical ground support equipments in several advanced countries.


OBJECTIVE
Dentin hypersensitivity (DH) is characterized by a short, sharp pain in response to a thermal or tactile stimulus. The application of desensitizing agents such as GLUMA and laser is a non-invasive and safe approach to decrease sensitivity. The evidence for the efficacy of GLUMA desensitizer compared to laser desensitization in patients with DH was evaluated for 6 months.

DESIGN
In March 2022, an electronic search of PubMed, Scopus, and Web of Science databases was conducted. Articles published in English that compared GLUMA and laser in the treatment of DH with a follow-up of 6 months or more were included. Randomized, non-randomized controlled trials, and clinical trials were included. Risk of bias assessment tools developed by the Cochrane collaboration ROB 2 and ROBINS-I were used to assess the quality of studies. The GRADE assessment method was used to assess the certainty of evidence.

RESULTS
About 36 studies were identified in the search results. After applying the predefined eligibility criteria, eight studies with 205 participants and 894 sites were included in this review. Of the eight studies, four were judged to be at high risk of bias, three had some concerns, and one had a serious risk of bias. The certainty of the evidence was graded as low.

CONCLUSION
Based on limited evidence, GLUMA and laser appear to be equally effective in providing relief from DH. GLUMA showed an immediate effect and provided pain relief. Over the course of a week, laser showed long-term stable results. GLUMA is effective in providing immediate relief.


From box 2 folder 16 - Drafts and copies of statement of Reavis to Congress; biographies of congressmen involved in the hearings; cover letter from Rick Sherrow to Reavis enclosed with disk transcripts of hearings.


Objective To observe the efficacy of low energy He-Ne laser intravascular irradiation in the treatment of schizophreni a.Methods 90patients with the first episode sc hizophrenia were randomly divided i nto 2groups.The first one was He-Ne l aser intravascular irradiation gro up of 45patients.The other 45patients were treated as the contrast group.B oth groups tested the function of liv er and kidney,EKG,PT,APTT,TT,Fib,INR,BPRS,TESS before and after treatment.All the patients only too k risperidone.The first group was ir radiated every other day,60minutes each time.Ten times is a period.The e fficacy was divided into four levels.The data processing was t-test and Ridit analyzing.Results The pa-tients with the He-Ne laser intravascular irradiation BPRS marks decrea sed more(P0.05)rapidly than those without it and were in hospital for a shorter time (P0.05).Also the efficacy would be much better(P0.05).TESS masks and blood coagulation fu nction of the two groups make no difference before and after t he treatment.Conclusion The only problem for He-He laser intr avascular irradiation in the treatm ent of schizophrenia is to master the radic ation properly.The result is not onl y satisfying but also quite safe.


A parallel-plate waveguide filled with a homogeneous cold time-varying plasma is analyzed. A problem of excitation and propagation of the axially symmetric electromagnetic waves in such a waveguide is solved. To obtain a solution, the resolvent operator in the cylindrical coordinate system is built that allows an exact and explicit expression to be obtained for the electromagnetic field. Several examples of the step-type driving currents are considered. These results can be used for the validation and accuracy testing of FDTD and other numerical solutions to the transient problems.


As a result of manufacturing processes, real surfaces have roughness and surface curvature. The real contact occurs only over microscopic contacts, which are typically only a few percent of the apparent contact area. Because of the surface curvature of contacting bodies, the macrocontact area is formed, the area where microcontacts are distributed randomly. The heat flow must pass through the macrocontact and then microcontacts to transfer from one body to another. This phenomenon leads to a relatively high temperature drop across the interface. Thermal contact resistance (TCR) is a complex interdisciplinary problem, which includes geometrical, mechanical, and thermal analyses. Each part includes a micro and a macro scale sub-problem. Analytical, experimental, and numerical models have been developed to predict TCR since the 1930's. Through comparison with more than 400 experimental data points, it is shown that the existing models are applicable only to the limiting cases and none of them covers the general non-conforming rough contact. The objective of this study is to develop a compact analytical model for predicting TCR for the entire range of non-conforming contacts, i.e., from conforming rough to smooth sphere-flat in a vacuum. The contact mechanics of the joint must be known prior to solving the thermal problem. A new mechanical model is developed for spherical rough contacts. The deformation modes of the surface asperities and the bulk material of contacting bodies are assumed to be plastic and elastic, respectively. A closed set of governing relationships is derived. An algorithm and a computer code are developed to solve the relationships numerically. Applying Buckingham Pi theorem, the independent non-dimensional parameters that describe the contact problem are specified. A general pressure distribution is proposed that covers the entire spherical rough contacts, including the Hertzian smooth contact. Simple correlations are offered for the general pressure distribution and the radius of the macrocontact area, as functions of the non-dimensional parameters. These correlations are compared with experimental data collected by others and good agreement is observed. Also a criterion is offered to identify the flat surface, where the effect of surface curvature on the contact pressure is negligible. Thermal contact resistance is considered as the superposition of macro and micro thermal components. The flux tube geometry is chosen as the basic element in the thermal analysis of microcontacts. Simple expressions for determining TCR of non-conforming rough joints are


Oxidative stress‐mediated LDL modification has a key role in initiation of the atherosclerotic process. Platelets produce reactive oxidant species (ROS) upon stimulation with agonist, but it is uncertain whether they are able to oxidatively modify LDL. Human platelets taken from healthy subjects were incubated with LDL, then stimulated with collagen. Compared with unstimulated platelets, collagen‐stimulated platelets induced LDL modification as shown by enhanced conjugated dienes and lysophosphatidylcho‐line formation, electrophoretic mobility, Apo B‐100 degradation, and monocyte LDL uptake. Activated platelets also induced a marked reduction of vitamin Ε contained in LDL. A significant inhibition of LDL oxidation was observed in platelets treated with arachi‐donyl trifluomethyl ketone (AACOCF3), an inhibitor of phospolipase A2. The experiments reported above were also conducted in patients with hereditary deficiency of gp91phox, the central core of NADPH oxidase, and in patients with hypercholesterolemia. Platelets from gp91 phox‐deficient patients produced a small amount of ROS and weakly modified LDL. Conversely, platelets from hypercholesterolemic patients showed enhanced ROS formation and oxidized LDL more than platelets from healthy subjects. This study provides evidence that platelets modify LDL via NADPH oxidase‐mediated oxidative stress, a phenomenon that could be dependent on arachidonic acid activation. This finding suggests a role for platelets in favoring LDL accumulation within atherosclerotic plaque.—Carnevale, R., Pignatelli, P., Lenti, L., Buchetti B., Sanguigni, V., Di Santo, S., Violi, F. LDL are oxidatively modified by platelets via GP91phox and accumulate in human monocytes. FASEB J. 21, 927–934 (2007)


In Todhunter's Compound Interest (4th edition, chapters 8 and 9) several methods are given for the approximate determination of the rate of interest involved in a given transaction. In these methods there is no adequate treatment of the errors contained in the results. No simple means are given whereby the computer can tell to how many significant figures the results can be trusted.


This paper discusses the rise and trends of Muslim/ Islamic feminism in the wake of application of Shariah in Northern Nigeria. It specifically studies the role of Hauwa Ibrahim in fighting for the rights of women in Shariah criminal cases and her approaches and strategies for winning the cases. It claims that though Hauwa Ibrahim's strategy does not overtly proclaim feministic approach, the feminist card had been played in the way she and her alliance had portrayed the cases. The claim of the feministic approach of Ibrahim is inferred from the analysis of criminal cases reported in Weimann article on Islamic Criminal Law in Northern Nigerian. The analysis elucidates and reveals that the number of female victims and the claim of women discrimination during the implementation of Shariah in Northern Nigeria are exaggerated.


Coscinium fenestratum (tree turmeric), family Menispermaceae, a critically indangered shrub, widely used in folk and ayurvedic systems of medicine. This review gives the detailed survey of the literature on chemistry and medicinal properties of Coscinium fenestratum. The chemical constituents reported from C.fenestratum belongs to different classes of alkaloids, some minor alkaloid as well as ceryl-alcohol, saponin, hentriacontane, sitosterol glucoside, palmitic acid, oleic acid isolated from stem and roots of this plant. Among these, berberine has been reported to be the major and active constituent having numerous biological activities. The remarkable medicinal properties reported are wound healing activity, antifungal, antibacterial, hypotensive, anti-hyperglycemic activity, anti proliferative, Antihepatotoxic, antipyretic, antiulcer, antioxidant, anticancer and neurotoxic activities.


Non-determinism Analysis in a Parallel-Functional Language.- Exploiting Implicit Parallelism in Functional Programs with SLAM.- Verifying Generic Erlang Client-Server Implementations.- The Design and Implementation of Glasgow Distributed Haskell.- Implementation Skeletons in Eden: Low-Effort Parallel Programming.- ObjectCurry:An Object-Oriented Extension of the Declarative Multi-Paradigm Language Curry.- Distributed Programming in Haskell with Ports.- The Dynamic Properties of Hume: A Functionally-Based Concurrent Language with Bounded Time and Space Behaviour.- A Usage Analysis with Bounded Usage Polymorphism and Subtyping.- Polygonizing Implicit Surfaces in a Purely Functional Way.- Freja, Hat and Hood - A Comparative Evaluation of Three Systems for Tracing and Debugging Lazy Functional Programs.- Porting the Clean Object I/O Library to Haskell.- Organizing Speculative Computations in Functional Systems.- Improving Cache Effectiveness through Array Data Layout Manipulation in SAC.- The Collective Semantics in Functional SPMD Programming.


The development of county-level hospitals in proverty-striken areas have to based on the guidance of scientific concept of development.All the medical workers should make their great efforts to find an effective way to improve the conditions of their hospitals on all sides.In the retrospective analysis of the development of people's hospitals in Tanchang,its experience,problems on the basis of the approaches to development,l have come to draw the conclusion about the reason why people's hospital of Tanchang county has developed so rapidly is that we havefollowed the laws of the scientific concept of development and practiced by ourselves.County-level hospitals in poverty-stricken areas must face the realism,try for development with scientific concept,pay close attention to the implementation of management,project,human resources development strategy and not to relax,can we achieve the sense of being true scientific development.


Given the enormous changes in physiology and neurobiology prevalent during adolescence, it is hardly surprising that this is also the time when metabolic control of diabetes is at its worst. Clinical teams are constantly looking for ways to improve diabetes control in youth and exploiting the perceived fascination of adolescents for new technology offers an attractive option. The management of type 1 diabetes has always been heavily influenced by new developments and this personal review, influenced by a long experience of working with adolescents, explores how some of the emerging technologies have been used in an attempt to influence diabetes control in this challenging age group. Copyright © 2012 John Wiley & Sons.


The study aims at understanding the role of DNA in biotechnology use in forensic sciences. Every organism has unique DNA sequences just like each individual has got unique finger print. In forensic science individuals are identified by scanning for 13 DNA regions, that vary from person to person and they use this information to create DNA profile or DNA fingerprint of that particular individual. There is very little possibility of another person having the same DNA profile or DNA fingerprint for this particular 13 DNA regions. At present identifying each individual belonging to same species is little bit less precise, but as the technology of DNA sequencing progresses, comparison of large part of genome or DNA fragment or even the whole genome will become feasible, easy and also precise in identifying individuals belonging to the same species.


Abstract. Barus J, Meithasari D, Lumbanraja J, Sudarsono H, Hidayat KF, Dermiyati. 2021. Soil mesofauna amount and diversity by returning fresh and compost of crops biomass waste in ultisols in-situ. Biodiversitas 21: 92-98. Newly added organic matter to the soil often has no significant effect on the physical and chemical properties of the soil. However, the addition of organic matter greatly affects the abundance and diversity of living organisms in the soil, because the addition of organic matter is one of the sources of food. The aim of this research was to study the impact of returning crop biomass waste in fresh or compost forms on the abundance and diversity of soil mesofauna. Three types of crop biomass residues (i.e. maize stover, rice straw, and soybean stover) were used at doses of 0, 2.5, 5.0, 7.5, and 10 t ha-1. Mesofauna observations were carried out three times, namely at two weeks after biomass waste application (before planting rice), at eight weeks (there were rice plants in the soil), and at fourteen weeks (after rice harvest). The soil sample for mesofauna observation was dry extracted using a Berlese funnel set up, and to calculate and identified using a binocular microscope. The result showed that the number and diversity of mesofauna in the addition of compost was higher than that of fresh biomass waste. Increasing the dose of biomass waste has an effect on increasing the number and diversity of soil mesofauna. The presence of rice plants in the soil at the time of observation also affected the abundance of soil mesofauna.


Abstract Under investigation in this article is a (2+1)-dimensional generalised variable-coefficient shallow water wave equation, which describes the interaction of the Riemann wave propagating along the y axis with a long-wave propagating along the x axis in a fluid, where x and y are the scaled space coordinates. Bilinear forms, Bäcklund transformation, Lax pair, and infinitely many conservation law are derived based on the binary Bell polynomials. Multi-soliton solutions are constructed via the Hirota method. Propagation and interaction of the solitons are illustrated graphically: (i) variable coefficients affect the shape of the multi-soliton interaction in the scaled space and time coordinates. (ii) Positions of the solitons depend on the sign of wave numbers after each interaction. (iii) Interaction of the solitons is elastic, i.e. the amplitude, velocity, and shape of each soliton remain invariant after each interaction except for a phase shift.


Class teaching authority (TA) refers to teachers' authority to choose, manage, and judge the factors which are concerned in the process of teaching. Under the influence of traditional Chinese hierarchical social class and feudal ruling ideology, teachers' behavior in China generally exhibits controlling and restraining. It is the common pursuit of feminism to care for the weaker groups and to realize equality of sexes. Therefore, from the perspective of liberation, feminism endeavors to liberate those who are suppressed in education and to raise their awareness of equality, hence, promote their self-consciousness in development. Following this principle, there are three ways to achieve the feminist TA: 1. Students should be empowered to share authority with teachers; 2. A learning community should be built; and 3. A caring relationship should be created between teachers and students.


KEARNEY, DIANN PICKARD. Factors that Influence Effective Veteran Teachers' Decisions to Remain in High-Poverty Elementary Schools. (Under the direction of Bonnie Fusarelli and Matt Militello, Co-Chairs.) The purpose of this expository case study is to determine what factors influence the decisions of effective veteran teachers to remain in high-poverty elementary schools in an urban school district. I wanted to explore why, given the high rate of growth and the high attrition rate in this school system, like other urban districts, effective veteran teachers identified stay at these more challenging schools. This study sought to identify the contributing factors and explore these factors as they relate to educational leaders who focus on teacher retention. Data gathered through interviews with the principals and 15 teachers of three high-poverty elementary schools indicate that school systems and principals should implement buildingand system-level changes to better retain effective veteran teachers at high-poverty schools. Factors that Influence Effective Veteran Teachers' Decisions to Remain in High-Poverty Elementary Schools


In the presence of fluoride ion, peror polyfluoroaromatic siloxanes C6F50Si(CH3)3 (l), (CH3)3SiOCdj4OSi(CH3)3 (2), 1-fluoro-2,3-bis((trimethylsilyl)oxy)benzene (3), and (CH3)3SiOC(CF&C84C(CF3)20Si(CH3)3 (4) are useful transfer reagents for the synthesis of monoand diethers. Siloxane 1 forms RPCF2Br (S), (RP)&F (61, RPCH20Rf (7), (RPhCHCWORd2 (8), (RP12SO (91, (RP)2CO (lo), C3NdORd3 (11), R P C W


NASA's Advanced Radioisotope Power Systems (RPS) development program is developing next generation radioisotope power conversion technologies that will enable future missions that have requirements that can not be met by either photovoltaic systems or by current Radioisotope Power System (RPS) technology. The Advanced Power Conversion Research and Technology project of the Advanced RPS development program is funding research and technology activities through the NASA Research Announcement (NRA) 02OSS-01, "Research Opportunities in Space Science 2002" entitled "Radioisotope Power Conversion Technology" (RPCT), 13 August 2002. The objective of the RPCT NRA is to advance the development of radioisotope power conversion technologies to provide significant improvements over the state-of-practice General Purpose Heat Source/Radioisotope Thermoelectric Generator by providing significantly higher efficiency to reduce the number of radioisotope fuel modules, and increase specific power (watts/kilogram). Other Advanced RPS goals include safety, long-life, reliability, scalability, multi-mission capability, resistance to radiation, and minimal interference with the scientific payload. These advances would enable a factor of 2 to 4 decrease in the amount of fuel required to generate electrical power. The RPCT NRA selected advanced RPS power conversion technology research and development proposals in the following three areas: innovative RPS power conversion research, RPS power conversion technology development in a nominal 100W e scale; and, milliwatt/multi-watt RPS (mWRPS) power conversion research. Ten RPCT NRA contracts were awarded in 2003 in the areas of Brayton, Stirling, thermoelectric (TE), and thermophotovoltaic (TPV) power conversion technologies. This paper will provide an overview of the RPCT NRA, and a brief summary of accomplishments over the first 18 months but focusing on advancements made over the last 6 months.


A gathering of dreams fictions of the divided mind fictions of history fictions of self?. Appendices: Langland and Deguileville - "Le Pelerinage de Jhesucrist" Piers Plowman and Saint Peter - B XV 195-212.


By now, almost everyone in computer graphics has read, seen, or experienced virtual worlds--"artificial realities" generated by computers which surround the user. Virtual.world systems are the focus of the media, grist for the TV mill, and everyone's pick as "The Big Idea of the 90s." But what does it all mean? Is virtual-worlds technology really that important? Panelists address the artificial reality controversy and suggest the filture of professional and personal computer use. Bob Jacobson I 'm Bob Jacobson and I 'm the chair of the panel. In my other life, I 'm the associate director of the Human Interface Technology Laboratory, part of the Washington Technology Centers at the University of Washington. Our job is to develop virtual technology, to find applications for it, and that is the job of all the other people you will hear today. There have been a couple of changes in the panel line-up. I think we have an amazingly exemplary panel. It keeps getting better. Nolan Bushnell could not be with us because he had to do some work elsewhere, and Tom Furness had the same situation. Our panel had the fortunate addition of Jaron Lanier and William Bricken. I think that you'll find this is an incredible group of people. We sat down last night, very anxious about how we would interact before you and within fifteen minutes we had a discussion going that lasted for nearly two hours: I hope we didn't talk ourselves out! I think you'll find that there is a lot of learning going


Urban villages, namely villages encircled by urban environments, are unique phenomena that proliferated during China's rapid urbanization process, as well as important development issues for many Chinese cities at present. This article focuses on two planning approaches for urban villages, dominated by the government's uniform and formal planning and villagers' spontaneous and informal planning practices, aiming to examine which planning approach is more conducive to urban village development. The two planning approaches for urban villages have simultaneously appeared in Hangzhou, a Chinese metropolis with a combination of high-speed economic growth, a unique geological environment, and a long cultural history, providing appropriate comparative study cases for this research. Two urban villages, Luojiazhuang and Yangjiapailou, located in plain and hilly areas in Hangzhou, respectively, and developed through the two planning approaches were selected as study cases. Primary data were collected based on field investigations, semi-structured interviews, and questionnaire surveys. The villagers' rental income, shopkeepers' business benefits, and tenants' residential satisfaction were investigated to compare the development of the two urban villages. Results indicate that compared with the formal planning-dominated approach, the informal planning-dominated approach achieves continuously rising rental income, more stable business benefits, and higher residential satisfaction, better suited to urban village development. This study contributes to coordinated urban–rural interaction in the urbanization process and enriches the formality–informality debates from a spatial planning perspective.


"disaster-sightseeing" he indulged in after the 1923 quake, we should also remember that, to use his own phrase, he was already a "master of funerals" long before this particular experience of death and disaster (having lost every last member of his immediate family in childhood). To use him as a representative example of a quake-affected or quake-traumatized author thus seems rather problematic. Also, although the urban environment may not have featured as prominently as in Asakusa kurenaidan in any of his later works, it would be a mistake to think that Kawabata ever returned to the kind of self-satisfi ed, navel-gazing inwardness of the Taisho naturalists and I-novelists. One might offer a late story such as "Kata ude" (One arm, 1964), for instance, as a remarkable example of how his fi ction can be both intensely subjective and intensely objective at the same time. Of course, none of this detracts in any way from my high estimation of Bates's achievement here. The Culture of the Quake is a seminal work that will help shape scholarly debate on this topic for a long time to come.


The restriction from system is a main restricting factor of Chinese urbanization intensivism. Therefore, to breakthrough old system restriction is a key factor of intensive urbanization. The author sums up, with the practice of Shunde city, some way, including to reform for residence registration; adjust strategic to rural economic structure, running mechanism and managing method; open up financing way of infrastructure through investment system reform; zoning adjustment and set up new social security adapting with marketing economy and urbanization.


This review provides a closer look at recent work in the field of fireworks
manufacture, which could see the replacement of micron-sized particles with their nano-scaled counterparts.
Moreover, we also discuss micron-sized particles as well as nanoparticles (NPs) from K, Fe,
Al, Ti, Ba, etc., that are produced in the atmosphere as a result of these fireworks. One of the possible
technological substitutes for fireworks is presented in detail, i.e., the use of ultrasonic spray pyrolysis
(USP) technology.

 We searched Google, Web of Science and PubMed for a literature survey of fireworks and
their products: firecrackers, micron-sized and nanoparticles. Moreover, we used some of our own
knowledge and experimental data to strengthen the possibility of simulating the synthesis of firework
products on the laboratory scale.

 The use of nano reactants and oxidisers has seen a substantial increase in the sound efficiency
and a decrease in the amount of chemicals used, making fireworks more eco-friendly. The
application of Al- and Ti-based nano flash powder in the size range from 35 nm to 50 μm resulted in
a significant improvement in the ignition properties of the fireworks. Under changing aerodynamic
conditions, it is difficult to collect them as samples for real-time monitoring, needed for their characterization
or the testing of their harmfulness under laboratory conditions. As a result, NPs below 100
nm in the surroundings could be easily inhaled into the lungs and cause more pulmonary and respiratory
problems than micron-sized particles. USP produces nanoparticles in the laboratory that could
replace the conventional micron-sized firecracker raw materials, or nanoparticles that are similar to
those formed by fireworks. It will also help to identify the physiochemical properties of the airborne
particulates in order to understand and evaluate their impact.

This review could be valuable for a controlled economic synthesis through USP, and in the use of
nanopowders in pyrotechnology that could reduce pollution to a great extent, thus contributing to the
growth and good practise of the fireworks industry. With respect to the USP synthesis, we have also
discussed in detail the physical (size, shape) and chemical (composition) characteristics of Al2O3 and
TiO2 NPs from different precursors and their temperature ranges. An in-depth explanation for a comparative
analysis for the formation mechanism of nanoparticles through both fireworks and USP is
presented in the final section.

 We can produce nanoparticles in the laboratory with ultrasonic spray pyrolysis that
have similar properties to those produced from fireworks and can then be used for further testing.


This paper describes how the need for a superior and durable concrete capable of resisting environmental distress resulted in the development of high performance concrete (HPC) for bridge decks. This paper focuses on the Washington State Department of Transportation (WSDOT) standard practice of using HPC for bridge decks.


Incontinence is one of the main reasons for institutionalisation into residential aged care. It is linked with increased falls, skin breakdown, depression, social isolation and impaired quality of life. Studies over the past decade have demonstrated poor‐quality incontinence care, which has led to ongoing development of best practice guidelines and educational resources. This study investigated current practices, and staff and resident experiences with continence assessment and management, in comparison with best practice guidelines.


This paper illustrates the sound vibration phenomenon of mono type TV set produced by spearker and suggests guidelines for reducing the noise induced by the sound vibrations. In order to illustrate the sound vibration phenomenon, the structural acoustic coupled analysis for the grill and cavity of speaker and structural analysis for main frame are performed. To veify the structural analysis results, experimental modal test is carried out. It is found that the acoustic excitation in the cavity is negligible and main sound vibrations occur near the bottom of TV set. An improved model is found by doing structural modifications based on structural analysis and sound vibration tests are performed to verify the validation of the improved model. The obtained results are applied to similar models and design guide lines for noise reduction are suggested.


This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. For more information, please contact email@example.com. Recommended Citation Clare, Susan Kay, "A Study of Student Clinicians' Behaviors in Response to Feedback from the Analysis of Behaviors of the Clinician (ABC) System" (1975). Dissertations and Theses. Paper 2260.


In 2021, Bank Indonesia launched the National Open API Payment Standard (SNAP) to facilitate interoperable data-access for Indonesia's digital payments sector. This article examines the lessons learned from the UK's experience in open payments to improve the regulatory and institutional framework of Indonesia's open banking regime. This article employs a comparative legal analysis of the UK's open banking regime and concludes that Indonesia's open banking regime could be improved by expanding the delivery of the Open API standards enabling interoperable data access for the entire financial services sector through an outcomes-based approach. Such expansion could be facilitated by encouraging collaboration between banks and fintechs and by creating an Open Banking App Store to increase user adoption, enhance product visibility, and widen access to digital financial services for Micro, Small, and Medium Enterprises (MSMEs)


The invention discloses a high-yield cultivation method for mulberries. The method comprises the following steps: selecting a mulberry land: after harvesting spring crops in autumn or early winter each year, deeply ploughing the land once in time; selecting mulberry saplings: selecting grafted mulberry saplings which are suitable for local planting, pure in variety and uniform in sizes and have the characteristics of thick and strong mulberry saplings, complete root systems, no plant diseases and insect pests, good leaf texture, high yield and high stress resistance; managing a mulberry garden: a, performing intertillage weeding; b, applying spring, summer, autumn and winter fertilizers to the mulberry garden, wherein while applying the spring fertilizer, disbudding, pinching and trimming are performed.


The properties of crude xylanase and ~-xylosidase produced by Aspergillus niger NRClD7 in shake culture were investigated. Maximal activity of the two enzymes were recorded at 60°C and pH 4.5 and 5.0 respectively. The P-xylosidase activity was more thermostable than xylanase activity. Factors affecting the enzymatic hydrolysis of hemicelluloses obtained from different agriculture wastes were also studied. The extent of enzymatic hydrolysis decreased with the increase of· the substrate concentrations whereas it increased with increasing the concentration of enzymes. Incremental addition of substrate improved the saccharification yield. Significant inhibition of the saccharifying activity of A. niger NRC lD7 hemicellulase was obtained with initial xylose concentrations of 4.0 % or higher. Calcium ions activated the saccharifying activity, while Hg2+ and Mn2+ inhibited the activity. EDTA, Mg2+ and Fe2+ did not significantly affect the saccharifying activity of the organism hemicellulase. RESUME Les proprietes de la xylanase et de la B-xylosidase brutes obtenues apartir de la culture de r Aspergillus niger NRC 107 ont ete etudiees. L'activite maximum des deux enzymes a ere enregistrer aune temperature de 60 °C et a des pH de 4.5 et de 5.0 respectivement. L'activite du B-xylosidase 'Etait plus thermostable que celIe de la xylanase. Les facteurs affectant l'hydrolyse enzymatique des hemicellulases obtenues apartir de differents residus de recoltes ont egalement ete etudies. L'importance de l'hydrolyse enzymatique a diminue avec l' augmentation des concentrations du substrat et a augmenre la concentration des enzymes. L' ajout du susbstrat additionnel a ameUore Ie rendement de la saccharification. Une inhibition significative de I'activite saccharifiante de I'hemicellulase du A. niger NRC 107 a ete obtenue avec des concentrations initiates de xylose de 4,0 % ou plus. Les ions AFRICAN JOURNAL OF AGRICULTIJRAL SCIENCES VOL. 20, No. (1).1993 de calcium ont active l'activitC saccharifiante, tandis que Ie Hg2+ et Ie Mz2+ 1'0nt inhibite. L 'EDTA, Ie Mg2+ et Ie Fe2+ n'ont pas considerablement affecte l'activitC saccharifiante de l'hemicellulase.


Comments made by American Civil Liberties Union American Library Association American-Arab Anti-Discrimination Committee Campaign for Accountability Citizens for Responsibility and Ethics Government Accountability Project National Security Archive National Security Counselors The Niskanen Center OpenTheGovernment.org TechFreedom to the Department of Homeland Security on the proposal to amend the regulations under the Freedom of Information Act.


Surface cracks with aspect ratio can occur in pipelines subjected to corrosion attacks. There are few studies on interaction relationship for double semi-elliptical surface cracks with such high aspect ratio. This paper attempts to develop a finite element method to determine on interaction of two semi-elliptical internal surface cracks with high aspect ratio by analyzing two key fracture mechanics parameters, i.e., the stress intensity factor and the-stress. The numerical results prove that the existing flaw-interaction criteria are too general to lose the worthy of application especially in pipeline engineering.


Power system operation is increasingly dependent on the intermittent behavior of renewable energy sources. It is well known, that weather forecasts become more exact the shorter they look into the future. Hence, actual power system states differ considerably from the day ahead planning. To ensure the secure operation under these circumstances, the much more exact forecasts of 1 to 4 hours ahead must be used to determine the system security and enable sophisticated measures to be taken to prevent the system from suffering events like blackouts.


This paper describes a recent system dynamics modeling project about new housing construction and transformation of outdated dwellings and the impact of both processes on a regional social housing market in the Netherlands. A team of seven stakeholders and experts participated in model construction. The model was constructed over a period of about one year and yielded several counter-intuitive insights. The housing allocation system proved to have far smaller effect than expected, while the proportion of new green-field construction to transformation (demolition and new construction within the city) has emerged as a crucial steering factor. The migration multiplier is a very important external parameter. In line with the recommendations of a recent survey of group model building projects, participants' insights and conclusions from both the project and the workshop have been evaluated. The evaluation is based on Ajzen's theory of planned behavior and focuses on the effect of group model building on attitudes, intentions and behavior.


According to the insufficiency of antifreeze methods of current unsaturated concrete,this paper proposed sodium sulfate surface erosion test method,analyzed the basic idea,test procedures,test results and characteristics of this method,provided strong basis for improving the durability of concrete structures.


Objective To identify the 2-monoacylglycerols isolated from the metabolites produced by marine Streptomyces sp.211726.Methods A white crystalline powder was obtained from the fermentation products of strain 211726.Their structures were identified by the physicochemical and spectral analyses.Results and Conclusion The 2-monoacylglycerols obtained consisted of three components,and identified as: 15-methyl hexadecanoic acid 2-acylglycerol(1),hexadecanoic acid 2-acylglycerol(2) and 12-methyl tetradecanoic acid 2-acylglycerol(3) with the ratio of about 6∶3∶1.Among them,compound 1 was a new compound.


Abstract The article presents the advantages of using databases for the organization of folklore materials found on the internet, such as folktale archives, motif databases and books. It explores examples of databases that already exist on the internet and contain folklore materials and examines the possibility of establishing an open system of folklore databases and other projects that enable the participation of folklorists from around the world.


Nowadays, Limited Natural resources and population Growth demanded a fundamental change in economic policy. This paper tried to assess the link between economic growth especially green growth and Trade policy in the form of economic openness. The Study conducted by using survey literature and empiric. The outcomes of theoretical study of literature and empirical finding using panel data showed a significant effect of openness trade policy on Green GDP growth of countries.


Preface The Microsoft Excel window Formulas and formats Cell references and names Using functions The decision functions Printing a worksheet Charts Modelling Goal seek and solver Working with lists Dates and times Report writing Appendix A: Microsoft Excel add-ins Appendix B: Answers to problems Index


This thesis examines how young people identify and affliate with particular club scenes and how these practices and processes relate to their transitions, identities and lifestyles. It aims to give a sense of the processes and the resources that are required to 'become' a clubber over time. The thesis engages with the recent attempts to reconcile the conceptual and empirical divisions between the two main approaches in the sociology of youth. It suggests that the work ofSchutz serves as a heuristic framework to conceptualise data, and when synthesised with other sympathetic conceptual frameworks, links disparate literature to allow for a better understanding of the role of knowledge in the transitions, identities and lifestyles of young people. This focus influenced my choice of method: the ethnographic techniques of participant observation and in-depth interviewing were employed to access participants' experiences and knowledge of becoming a c1ubber. The findings suggest that the process of becoming a clubber is a gendered, dialectical and transformational process: informed by the social heritage and locally situated experiences of clubbing participants. It is a process that manifests itself through embodied practices involving cultural knowledge and taste. Participants place one another on the basis of their participation in and identification with a clubbing lifestyle. These placements appear embedded in the social order: they call not only on old social markers but also on the increasing hierarchies of difference within and across social groups. Social competence, cultural knowledge and consumer activities are all implicated in the placement of others, and the construction of boundaries that clubbing collectives engage in. These are young people who can afford materially and socially to extend both their structural and cultural transitions. The social confidence and adept skills of exchange that 'proper' clubbers develop are resources that help them develop and create social and cultural capital of their own. Becoming a clubber requires competency, skills and dispositions: it is a process that transmits privilege and disadvantage.


The invention discloses a voice over long term evolution (VoLTE) based desktop sharing method and device. The method comprises steps of capturing a screen image, and acquiring first image information of the screen image and sending the first image information to an opposite terminal, wherein the first image information comprises parameter information of the screen image; and receiving second image information of the screen image returned from the opposite terminal, analyzing the second image information according to the parameter information, acquiring an operational order of the opposite terminal for the screen image and performing the operational order. Through adoption of the method, desktop sharing and remote control of the mobile terminal are realized, the practicability, flexibility and interest of a video call are enhanced, and the user experience is improved.


Previous research has drawn attention to the coexistence of paradoxical Chinese values in modern China, which might influence Chinese-Western business negotiations. In this study, we empirically investigate this phenomenon from the perspective of Western business negotiators. In two interview rounds, 17 seasoned Dutch negotiators were asked about their experiences when negotiating with Chinese business partners. The results confirm the coexistence of paradoxical Chinese values in business negotiations and identify four patterns in which traditional and modern values may occur: random, contextual, transitional, and simultaneous occurrence. On the basis of our findings, we argue that there is a need for Western negotiators to develop a deeper understanding of Chinese culture and paradoxical values from the Chinese worldview of Yin and Yang.


To overcome design and integration challenges of microgrids with the legacy grid, the future power grid needs careful application of information and communication technologies. Additionally, to meet local needs and for better control, decentralized microgrids may be a realistic solution with controls that integrate communication, smart metering, and cogeneration. The real time information processing capability leads to a robust, cost-effective, and scalable solution. Next, to establish an efficient transaction infrastructure which will be transparent for select data and information types, while simultaneously keeping users' information private, a blockchain-based mechanism may be an acceptable approach. In this paper, we review research efforts and protocol implementations in this area. We contend that most prior work has focused on market-making aspects without sufficient focus on control system engineering for user privacy and system security in diverse possible blockchain energy grid redesigns.


We show that the I magnitude of the tip of the first-ascent red giant branch (TRGB) of low-mass stars is a distance indicator for resolved galaxies with metal-poor ([Fe/H]<−0.7 dex) old populations, having a precision comparable to primary distance indicators such as Cepheids and RR Lyraes. A comparison of the distances to resolved galaxies based on the TRGB with those derived from Cepheids and RR Lyraes shows that they agree within ±0.1 mag. Advantages of the TRGB method are discussed


This study focuses on cognitive representations of one's own and others' dyadic relationships and tests the principle that there is a self-serving bias in the assessment of them. Not only do people believe they are superior to other individuals on many psychological dimensions, called egocentric bias, they also believe that their dyadic relationships with others are superior. Participants, called key persons, were brought into the laboratory, and instructed to select three family members and three friends that they know well, and who also know one another within groups but not across groups. After doing so, participants made ratings of their own and others' dyadic relationships. This study concluded that key persons believe that listening quality is increased when they are present within the dyad, both as a speaker and as a listener. From this, we indicate possible future directions of study, as well as potential explanations for such a phenomenon.


This series of articles presents Roads & Bridges' top 10 bridge projects for 2013. Included are brief descriptions of the projects, as well as the costs involved. The projects include: 1) Route 460 Connector Phase 1 Design-Build, Grassy Creek Bridge in Breaks, VA; 2) Foothills Parkway Bridge No. 2 in Great Smoky Mountains National Park, TN; 3) Alexander Hamilton Bridge Rehabilitation in Manhattan and Bronx, NY; 4) Monongahela River Bridge in Brownsville, PA; 5) Lowry Avenue Bridge in Minneapolis, MN; 6) Red Gate Road Bridge in St. Charles, IL; 7) 130th & Torrence Truss Bridge in Chicago, IL; 8) U.S. 1 (S.R. 5) Low-Level Bridge Replacements Design-Build in Jupiter, FL; 9) I-90 Over the Mississippi River in Dresbach, MN; and 10) Memorial Bridge Replacement Project in Portsmouth, NH and Kittery, ME.


Reducing the cost and time associated with developing and deploying new control systems is a challenge facing all industries that rely extensively on control technology. The automotive industry furnishes a prime example, especially for powertrain control development. Computer-aided control system design (CACSD), a topic discussed in some generality in Chapter 3, provides the enabling tools for meeting this challenge. (For another example of an important application domain for CACSD, see Chapter lion flight control.) This chapter discusses in detail the process of developing automotive powertrain controller software. Powertrain control systems can be highly complex, integrating a number of different subsystems: fuel injection, throttle control, idle speed control, vehicle speed control, engine torque management, emissions control, knock detection, electronic transmission control, on-board diagnostics, and numerous others. The overall design must satisfy constraints and criteria imposed by government (such as fuel economy standards and emission thresholds), the corporate environment (which may demand support for legacy systems in addition to cost minimization and rapid time to market), and consumer preferences. To address the complexity of powertrain controller development, Ford Motor Company employs a systems engineering process. The emphasis is on validation or verification of products of all intermediate development stages, on the widespread implementation of feedback mechanisms, and on the continuing availability of support from engineering analysis and design teams. A requirements-based and CACSD- enabled development process has been implemented which incorporates requirements capture; architecture design; control feature design, implementation, and verification; and software validation, verification, and integra tion. The chapter also highlights the role of effective project management in large-scale control system development. Project management metrics can be integrated within the development process, and in the case of Ford these helped justify the CACSD project investment. Statistical data demonstrating the improvement in control software quality due to automation supported by CACSD tools is included.


Microglial cells are monocytic lineage cells that reside in the CNS and have the capacity to become activated during various pathological conditions. Although it was demonstrated that activation of microglial cells could be achieved in vitro by the engagement of CD40-CD40L interactions in combination with proinflammatory cytokines, the exact factors that mediate activation of microglial cells in vivo during CNS autoimmunity are ill-defined. To investigate the role of CD40 in microglial cell activation during experimental autoimmune encephalomyelitis (EAE), we used bone marrow chimera mice that allowed us to distinguish microglial cells from peripheral macrophages and render microglial cells deficient in CD40. We found that the first step of microglial cell activation was CD40-independent and occurred during EAE onset. The first step of activation consisted of microglial cell proliferation and up-regulation of the activation markers MHC class II, CD40, and CD86. At the peak of disease, microglial cells underwent a second step of activation, which was characterized by a further enhancement in activation marker expression along with a reduction in proliferation. The second step of microglial cell activation was CD40-dependent and the failure of CD40-deficient microglial cells to achieve a full level of activation during EAE was correlated with reduced expansion of encephalitogenic T cells and leukocyte infiltration in the CNS, and amelioration of clinical symptoms. Thus, our findings demonstrate that CD40 expression on microglial cells is necessary to complete their activation process during EAE, which is important for disease progression.


A collaborative product development environment requires sharing of product information among its participants. Product knowledge models and international standards have been developed for product information sharing. However, their models have limitations in representing their semantics explicitly, so a computer can not understand their semantics properly. It results in lack of information sharing. Recently, ontology gets attentions for automatic knowledge sharing because it can specify the semantics explicitly and logically. In addition, ontology-related standard language, such as web ontology language (OWL), is also proposed. In this paper, we propose an architecture for an ontology-based product knowledge and a product web ontology language (POWL) based on OWL. The architecture consists of three-level ontologies; meta-, generic and particular product ontology. The meta-product ontology is derived from previous top-level ontologies such as SUMO, DOLCE and Guarino's ontology. The generic product ontology is developed to provide comprehensive knowledge primitives representing product knowledge. A particular product ontology specify knowledge about a specific product such as car, telephone, ship, etc., and it is defined based on the generic product ontology. Meanwhile, POWL has product knowledge primitives defined in the generic product ontology, and it can be transformed to OWL. So users can define the specific product knowledge based on POWL. We implement the tranformation logic with XSLT and demonstrate a POWL usage with an example.Copyright © 2007 by ASME


In this paper, the effect of estimation error on the performance of Sign non-parametric control chart is considered. A simulation program has been prepared that calculate ARLs and cumulative distribution functions in sign chart for Normal, Uniform, Laplace and Cauchy processes. The simulations results show effects of estimation error in heavy-tailed distributions is greater than lighttailed distributions. Also, the effect of sample size on the estimation error is considered. The results specify the heavy-tailed distributions need to more samples than light-tailed distributions.In this paper, the effect of estimation error on the performance of Sign nonparametric control chart is considered. A simulation program has been prepared that calculate ARLs and cumulative distribution functions in sign chart for Normal, Uniform, Laplace and Cauchy processes. The simulations results show effects of estimation error in heavy-tailed distributions is greater than light-tailed distributions. Also, the effect of sample size on the estimation error is considered. The results specify the heavy-tailed distributions need to more samples than light-tailed distributions.


The article presents the notions connected with socialisation of first year university students, their ability of adapting to new academic environment and opportunities of using ICT in this capacity.


Social media plays an important role in disaster risk reduction and management. This study brings text, emotion, and timeline analyses together to increase our understanding of online travel community members' emotional dynamics and meaningful themes of concerns during the early months of the COVID-19 pandemic. Qualitative data was collected from three online travel communities on Reddit. We found that, as the pandemic continued, Redditors' concerns shifted from context-related external issues to daily-life-related internal issues. Furthermore, group-based emotions formed by the virtual community evolved positively, which can be beneficial for restoring confidence in travel after the pandemic. After presenting the results, we discuss their theoretical and practical implications.


The paper introduces the main function,realization technique and application of administrative automatic system based on the B/S construction and operation flow technique in Guizhou Academy of Agricultural Sciences and discusses the guiding ideology,key technique and application effect in the system development.The system plays the important effect in realizing administration automation,sharing information resouces,building agricultural scientific research units with a resource-saving type and promoting the management effects.