Introduction
 Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Treatment options include surgery, radioiodine & hormonal therapy. Radioiodine therapy (RAI) is often used after surgery with the purpose of ablation of residual thyroid tissue, adjuvant therapy or clinically evident metastatic disease. However, the use of RAI carries a risk of secondary malignancies, such as leukemias.
 The 10-yr survival rate of patients with DTC > 90%. However, several studies showed those patients may be at risk for secondary cancers.
 Therapy related myeloid neoplasm (tMN) can develop after RAI exposure.
 The relationship between thyroid and myeloid neoplasm (MN) may not be fully explained by exposure to RAI.
 In this retrospective study, we investigated the association between MN & DTC.
 Methods
 This study included patients >18years with DTC and either MN ((Acute Myeloid Leukemia (AML), Myelodysplastic syndrome (MDS), Chronic myelomonocytic leukemia (CMML), or Myeloproliferative Neoplasms (MPN) who had been diagnosed and/or treated at UTMD Anderson Cancer Center from 1/2012-12/2020
 Descriptive statistics were performed to define the demographic, clinical and biological characteristics of the patients included in the study.
 Results
 Fifty-four pts had both DTC and MN. The median age was 52 yrs (18-77). Most of the patients were white 41/54 (75.9%) with equal sex distribution and of the papillary subtype of DTC 48 (88.8%). DTC stages were I (15(42.86%), II -15 (42.86%) III & IV- 5 cases (14.29%). Of the MN patients, AML/MDS cases were 30 (56.36%), while MPNs cases were 24(43.64%). Majority were CML 13/24 (54%) (p =0.01). The most common cytogenetics karyotypes detected were diploid in 17 (30.91%) followed by complex in 8 patients (14.55%). The most frequent positive mutation was FLT3 in 6 cases (10%) followed by TP53 and ASXL1 with 5 (9.26%) patients respectively. While the mutation panel were negative in 16 patients (29.63%).
 RAI was used in 42(76.36%) patients, with a median dose 142 mCi (75-290). Thirty patients (70%) of those treated with RAI developed therapy related MN, while 12 patients had MN earlier occurred first in 34 patients (61.82%) (proceeded AML/MDS in 23 (74.19%) and 11(45.83%) (P= 0.005) in cases of MPNs. The median time lapse from developing thyroid to myeloid cancer was 4 years. Thyroid cancer proceeded AML or MDS by 2.5 years, while thyroid cancer happened around the same year (0.09) with MPNs (p= 0.04) Table 1
 A hypomethylating agent (HMA) based therapy for myeloid neoplasm was the most commonly used in 15 (42.86%), other therapies included cytarabine (5), cladribine (4) & fludarabine (3) based .37 pts (67.27 %) achieved complete remission, while 18 (32.73%) underwent stem cell transplantation.
 Overall survival showed that 40 (74%) were still alive. Therapy related AML/MDS Overall survival were inferior to non-therapy related patient (p= 0.29) figure 1. Patients who had 3 or 4 types of cancer to the group who had only thyroid and myeloid cancer showed increase risk of death with a hazard ratio of 1.72 (0.62-4.77 however this was not statistically significant also (p= 0.30).
 Conclusion
 In our cohort patients who were exposed to Radioiodine (RAI) had developed therapy related myeloid neoplasm (t-MN) AML/MDS even with doses < 100 mCi. Median to develop neoplasm (t-MN) were 4 years, complex cytogenetics is frequent. No statistically significant difference in survival between therapy related and none therapy related group. DTC did occur with MPNs as well with CML most frequent subtype. Prospective studies need to be done to further elucidate the relationship between DTC & MPN.
 Figure 1 Figure 1.

 Pemmaraju: ASCO Leukemia Advisory Panel: Membership on an entity's Board of Directors or advisory committees; Affymetrix: Consultancy, Research Funding; ASH Communications Committee: Membership on an entity's Board of Directors or advisory committees; Cellectis S.A. ADR: Other, Research Funding; CareDx, Inc.: Consultancy; LFB Biotechnologies: Consultancy; MustangBio: Consultancy, Other; Plexxicon: Other, Research Funding; Aptitude Health: Consultancy; Stemline Therapeutics, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other, Research Funding; Abbvie Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other, Research Funding; Protagonist Therapeutics, Inc.: Consultancy; Incyte: Consultancy; Sager Strong Foundation: Other; Daiichi Sankyo, Inc.: Other, Research Funding; HemOnc Times/Oncology Times: Membership on an entity's Board of Directors or advisory committees; Celgene Corporation: Consultancy; Samus: Other, Research Funding; Novartis Pharmaceuticals: Consultancy, Other: Research Support, Research Funding; Springer Science + Business Media: Other; Dan's House of Hope: Membership on an entity's Board of Directors or advisory committees; DAVA Oncology: Consultancy; Roche Diagnostics: Consultancy; Clearview Healthcare Partners: Consultancy; Blueprint Medicines: Consultancy; Bristol-Myers Squibb Co.: Consultancy; ImmunoGen, Inc: Consultancy; Pacylex Pharmaceuticals: Consultancy. Sasaki: Novartis: Consultancy, Research Funding; Pfizer: Membership on an entity's Board of Directors or advisory committees; Daiichi-Sankyo: Membership on an entity's Board of Directors or advisory committees. Verstovsek: Promedior: Research Funding; PharmaEssentia: Research Funding; NS Pharma: Research Funding; Ital Pharma: Research Funding; Incyte Corporation: Consultancy, Research Funding; Gilead: Research Funding; Genentech: Research Funding; CTI BioPharma: Research Funding; Celgene: Consultancy, Research Funding; Blueprint Medicines Corp: Research Funding; AstraZeneca: Research Funding; Protagonist Therapeutics: Research Funding; Roche: Research Funding; Novartis: Consultancy, Research Funding; Sierra Oncology: Consultancy, Research Funding; Constellation: Consultancy; Pragmatist: Consultancy.


Objective To investigate and summarize the reason and treatment of early portal vein thrombosis(PVT) after orthotopic liver transplantation(OLT).Methods A retrospective study was performed on etiology,prognosis and treatment in 3 cases of early PVT after OLT.Results One case did not avoid the graft loss and undergo retransplantation after failure of surgical thrombectomy and anticoagulant therapy.One patient died of serious pulmonary fungal infection and multiple organ failure on 35th day following retransplantation.Benefiting from close monitoring with color Doppler ultrasonography(CDUS),one case was treated successfully with prompt thrombectomy and anticoagulant therapy.Conclusion Early PVT after OLT is a life threatening complication associated with a high rate of graft loss and patient death.The key points of preventing early PVT after OLT include enough portal blood flow,decreasing portacaval shunt and early anticoagulant treatment after operation.Monitoring portal venous dynamics with CDUS and promptly surgical therapy are essential to improve prognosis of early PVT following OLT.


PURPOSE: To obtain a high-molecular weight polyimide comprising a specified structural unit in a manner in which side reaction can be prevented by reacting 3,3',4,4'-benzophenonetetracarboxylic dianhydride with an equimolar amount of 2,4- and/or 2,6-tolylene diisocyanates and a polymerization accelerator. CONSTITUTION: 3,3',4,4'-Benzophenonetetracarboxylic dianhydride is reacted with an equimolar amount of 2,4- and/or 2,6-tolylene diisocyanates and a polymerization accelerator (e.g. sodium methylate) to obtain the polyimide comprising a structural unit represented by formula I (wherein n is 1 or greater; and R is a group of formula II or III). COPYRIGHT: (C)1990,JPO


To tackle characteristics of nonlinear and low accuracy for traditional reliability assessment,a novel machine tool reliability assessment method based on Bootstrap and Support Vector Machines(SVM) was proposed.The reliability assessment models for point estimation and confidence interval were respectively set up under the condition of the small sample.A sequence diagram of unified modeling language was adopted to describe the entire process of machine tool reliability assessment.A case was implemented by simulation analysis to validate the method.It suggested that the nonlinear and low accuracy encountered in classic machine tool reliability assessment might be solved by using the proposed method when only small sample was obtained.


The pretreatment of copper anode slime for concentrating gold and silver was studied. The leaching rate of copper is 90% after the sulfuric acid leaching when leaching temperature is 353 K,n(H2SO4):n(Cu) is 1.5,liquid-solid ratio is 3:1 and reaction time is 1.5 h. Then the decopper anode slime is milled with sodium carbonate and leached by nitric acid solution. The leaching rate of lead is 69.5% when the milling conditions are as follows:milling time is 3 h,n(Na2CO3):n(Pb) is 2.5,liquid-solid ratio is 2:1,ball-to-powder mass ratio is 8:1 and the leaching conditions are as follows:n(HNO3):n(Pb) is 6.0,leaching time is 0.5 h and leaching temperature is 296 K. After the pretreatment process,the results show that the contents of gold and silver increase from 0.152% and 7.81% to 0.31% and 13.7%,respectively. The amount of anode slime is reduced by half,the production capacity of rotary kiln is enhanced greatly and the emission of SO2 is decreased.


A compact triple-band PIFA antenna is proposed in this paper for implantable biomedical applications covering industrial, science and medical (ISM) band 915 MHz, wireless medical telemetry service (WMTS) band 1.43 GHz and ISM band 2.45 GHz. In a single layer and one slotted structure, the triple band has been obtained by the reflection of tank circuit concept. The magnitude of the reflection coefficient are −31.4, −16.9 and −30.4 dB and the peak gains of the antenna are −19.9, −22.2, and −12.8 dB at 915 MHz, 1.43 GHz and 2.45 GHz, respectively. It covers 68.2% of 915 MHz band, 42.8% of 1.43 GHz band and 62.5% of 2.45 GHz band. The antenna has been designed on a low cost FR-4 substrate and encapsulated by 0.5 mm thick Teflon layer to ensure bio-compatibility. The maximum SAR value has been calculated using CST voxel model and thus the maximum input power is obtained to ensure the safety level. The proposed antenna is compact in dimension consisting 10 mm × 10 mm × 1.5 mm while maintains its performance and simplicity.


AIM: To analyze the frequency of milk consumption and subjective symptoms of intolerance to dairy products in the population of three- to six-year-old girls (born and resident in Samara) based on the genotype of the lactase gene.
MATERIALS AND METHODS: We included 103 preschool girls ranging three to six years of age. Parents were questioned about the frequency of milk consumption by the child (per week), as well as the presence of gastrointestinal symptoms in their children (abdominal pain, bloating, flatulence and diarrhea) and the suspected association of symptoms with milk consumption (according to the parents). Buccal samples were taken from all girls to determine the polymorphism of the lactase genes (determination of C/T-13910 variant of the MCM6 gene).
RESULTS: A significant relationship between the frequency of milk consumption and the variant of the polymorphic locus of the lactase gene, MCM6 [C 13910T; which affects the expression of the lactase gene (LCT)] has not been established. There is no correlation in the enlarged gradation of frequent milk consumption (47 times a week) and rare milk consumption (23 times a week or less): of 53 girls with the CC genotype 27 (51%) often drink milk, 26 (49%) rarely drink milk; of 39 girls with CT genotype 23 (59%) often consume milk, 16 (41%) rarely consume milk; of 11 girls with the TT genotype, 8 (73%) often consume milk, 3 (27%) rarely consume milk (c2 1.94, p = 0.379). There was no significant relationship between the frequency of milk consumption, subjective symptoms of lactose intolerance (abdominal pain, bloating, flatulence and diarrhea) and the genotype; these symptoms were found only in four girls carrying the C allele (CC and CT genotypes) though not detected in girls with TT genotype.
CONCLUSION: In girls of 36 years old, there is no relationship between the frequency of milk consumption, subjective symptoms of lactose intolerance and genotype of lactase gene.


Granular materials, such as sand, biomass particles, and pharmaceutical pills, are widespread in nature, industrial systems, and our daily life. Fundamentally, the bulk mechanical behavior of such materials is governed by the physical and morphological features of and the interactions among constituent particles at the microscopic scale. From a modeling standpoint, the particle-based discrete element method (DEM) has emerged as the most prevalent numerical tool to model and study the behavior of granular materials and the systems they form. A critical step towards an accurate and predictive DEM model is to incorporate those physical and morphological features (e.g., particle size, shape, and deformability) pertaining to the constituent particles. The main objective of this dissertation is to approach an accurate characterization and modeling of the gradingand shape-dependent behavior of granular materials by developing DEM models that incorporate realistic physical and morphological features of granular particles. Revolving around this objective, three studies are presented: image-based particle reconstruction and morphology characterization, grading and shape-dependent shearing behavior of rigid-particle systems, and granular flow of deformable irregular particles. The first study presents a machine learning and level-set based framework to reconstruct granular particles and to characterize particle morphology from X-ray computed tomography (X-ray CT) imaging of realistic granular materials. Images containing detailed microstructure information of a granular material are obtained using the X-ray CT technique. Approaches such as the watershed method in two dimensions (2D) and the combined machine learning and level set method in three dimensions (3D) are then utilized and


Emeritus Professor of ETH Zurich, where he had come after a life full of academic responsibilities at home, Switzerland, in Canada, and at well-known international forums and prestigious research centers. And also full of senior intellectual production, dissolving permanently the boundaries of knowledge in his concern for the various branches of learning and his wise indistinct heterodoxy. Carouge, the High Middle Ages, Canaletto and Venice, the temple of Solomon, the Jeffersonian grid, the territory palimpsest, St. Petersburg and Washington, the hypercity ... you could say that nothing in this world was alien for him, and all his teachings shone like in the hands of the best specialist. His production did not cease in recent years, during which he could also experience the satisfaction of seeing how important compendiums devoted to his work were published in different countries and different languages.


ABSTRACT Introduction Pathogenic mutations of the abundant leucine-rich repeat kinase 2 gene support the onset of familial and sporadic forms of Parkinson's disease. These genetic variants catalyze kinase activity by substrate phosphorylation. They promote the nigrostriatal neurodegenerative process, i.e. characterized by Lewy body formation. Areas covered This narrative review discusses leucine-rich repeat kinase 2 inhibitors as therapeutic concept for beneficial disease modification following a literature search. Expert opinion Leucine-rich repeat kinase 2 gene function contributes to the onset of microglia inflammation, cellular, and mitochondrial dysfunction. Leucine-rich repeat kinase 2 inhibition with oral application of DNL151, respectively DNL201, and intrathecal administration of the antisense oligonucleotide BIIB094 in a single and multiple ascending dose study was safe and well tolerated. Approval of Leucine-rich repeat kinase 2 inhibitors in case of positive clinical study outcomes will introduce personalized medicine for beneficial modification of progression as the most unmet need for treatment of patients with Parkinson's disease. In addition to the currently, preponderantly performed clinical rating with established scales, further clinical trial endpoints, such as dosing of dopamine substitution, may be considered in study designs to demonstrate therapeutic effects on the progression of Parkinson's disease. Plain Language Summary Certain mutations of the abundant leucine-rich repeat kinase 2 gene contribute to the onset of inherited and sporadic forms of idiopathic Parkinson's disease. These genetic variants enhance the gene related kinase activity and promote nigrostriatal neurodegeneration with features like inflammation of microglia, cellular, and mitochondrial dysfunction. Inhibition of leucine-rich repeat kinase 2 activity was efficacious, safe, and well tolerated in experimental investigations and in the still ongoing clinical study program. Approval of this therapeutic concept after future positive clinical study outcomes is the introduction of personalized medicine based on molecular mechanisms and targets in Parkinson's disease. Beneficial modification of progression is the most unmet need for the therapy of patients with Parkinson's disease.


ABSTRACT The Acinetobacter baumannii clonal complex 113/79 (CC113/79) and class 2 integrons predominate in Latin America; a relationship between these characteristics was explored. The presence of integrases was determined in successive hospital Acinetobacter isolates (163 A. baumannii isolates and 72 Acinetobacter nosocomialis isolates). Most isolates had integrons, but class 1 and 2 integrons were present significantly more often in CC109/1 and CC113/79, respectively. The high prevalence of CC113/79 in Latin America may account for the predominance of class 2 integrons.


This study was conducted to determine the density index of phytoplankton and Aedes albopictus larvae found in breeding sites. The object of research was phytoplankton and Aedes albopictus larvae taken at Syiah Kuala District, Banda Aceh. Data was collected in December 2014 and January 2015. This study used a descriptive exploratory design. The research parameters are the type and density of phytoplankton found in various breeding places found at the study site. Data on the density of Aedes albopictus larvae was analyzed using the House and Container Index, and Density Index. This study found 15 species of phytoplankton with the larvae density index was 203 ind/L and phytoplankton density index was 649 ind/L.


This study explores the potential contribution to economic and cultural sustainability of fostering wine tourism activity in a Mediterranean mature mass tourism destination like the Balearic Islands. A causal model was designed linking winery visitors' satisfaction with both the local wines and the visit to the winery and future purchasing intentions as well as the interest in the destination cultural offer, global satisfaction with the trip, and image of the destination. Field research was carried out within the wineries where a questionnaire was administered personally to a sample of 200 winery visitors. The managers of the wineries were contacted previously to ensure their cooperation in the research. The statistical method used for the analysis of the exploratory causal model was the Partial Least Squares (PLS) regression. Results indicate that there is a great growth potential for wine tourism activity in the islands with important positive externalities on gastronomic tourism and the overall image of the Islands. Results show that wine tourism might boost the sales and exports of wine in the medium and long term. Finally, it can be concluded that there are important synergies between rural tourism, mass tourism, and wine tourism in the islands which are still not sufficiently optimized, and that greater support to wine tourism development could contribute not only to a more sustainable rural development but also to a more sustainable tourist activity overall within a more diversified economy.


A revised version of a talk given at the Management Science Conference in Mexico City, January 1970, sponsored by TIMS and the Department of Commerce.


Background and Objective: Maxillary sinus gradually extends laterally and inferiorly during pneumatization, and lamina dura of molar and premolar teeth can make a part of sinus floor. Knowledge about this anatomic relationship is essential to prevent complications paticularly iatrogenic perforation of sinus floor. Limitations of periapical and panoramic radiographs to visualization of this relationship led to the usage of cone-beam computed tomography (CBCT). This study was aimed to evaluate the vertical and horizontal relationship between roots of maxillary molars and sinus floor in CBCT images. Methods: In this descriptive cross sectional study, ninety-five samples were selected of patients in Department of oral and maxillofacial radiology in Tabriz, Iran using simple randomization. Mean age of patients was 32.5 years old. Images were made by VGi cone beam Newtom and reconstructed by NNT viewer version 2.17. The vertical and horizontal relationship between roots of 139 maxillary first and 126 second molar teeth and floor of sinus evaluated. Results: Type 2 was the most common relationship among the first and second molars, vertically (the inferior wall of the sinus located below the level connecting the buccal and palatal root apices,without an apical protrusion) and horizontally (the alveolar recess of the inferior wall of the sinus located between the buccal and palatal roots). There was a significant relationship between the type of tooth and sinus floor (P<0.05). Conclusion: Most of the maxillary molar roots were in contact with sinus floor and sinus floor was extended mostly between buccal and palatal roots vertically and horizontally, respectively. Attention to sinus involvement possibility during interventions in maxillary molar region is important.


The present invention is from about 3: 2: 1 of methane, the bimolecular dehydration of methanol produced from the resultant mixture of hydrogen and carbon dioxide by the reforming of water and carbon dioxide, a method of forming dimethyl ether. Next use of water obtained in the dehydration of methanol in the re modification, the overall ratio of carbon dioxide relative to methane is about 1: to produce dimethyl ether is three.


Strong patterns of concentration characterize the location decisions of development NGOs. Since current theories on non-profit location choice tend to neglect such tendencies, this article develops an evolutionary economic geography approach to non-profit organizations. It focuses on increasing returns to scale, labor mobility and path dependence and contextualizes those factors. A survey involving visual ranking methods of OECD-based development NGOs and structured field-level interviews with local NGOs in the Central African Republic and Tanzania provide original empirical data. Statistical methods are used to contrast the divergent experiences in the two countries. The article concludes that the increased interest of international NGOs in Tanzania and their continued lack of interest in the Central African Republic are self-perpetuating processes that explain the concentration of NGOs. This concentration may lead to increased efficiency, but reduces the equitable distribution of NGO aid and therefore has implications for the attainment of global poverty goals.


Snakebite is one of the common life-threatening medical emergencies, owing to the effects of the various toxins present in the venom and it is encountered in Indian population particularly in rural and farming areas. Cortical blindness following bites containing neurotoxin is a rare complication. Here we report the case of a patient with cortical blindness due to snake bite. Also we describe the clinical findings and imaging of a patient with hypoxic brain damage.


GaAs MOS capacitor with HfLaON as passivation layer and HfTiON as gate dielectric is fabricated and compared with its counterparts with LaON as passivation layer and no passivation layer. Results show that the sample exhibits better electrical properties: smaller hysteresis, higher k value (23.87), lower interface state density (9×10-5 cm-2 eV-1), lower leakage current (4.37×10-5 A/cm2 at Vfb+1V), smaller frequency dispersion and better high-field reliability. These should be ascribed to the capability of the passivation layer in suppressing the out-diffusion of Ga/As to the dielectric and in-diffusion of Hf/Ti/O to the substrate, thus reducing defective states to unpin the Fermi level at the dielectric/GaAs interface. Better passivation effect of HfLaON than LaON should be due to the reduced hygroscopicity of LaON by Hf incorporation.


This dissertation deals with the problem of recognizing a polyhedral object in two and three dimensions. We first consider different models for gathering information and state different assumptions that could be made about an unknown object to be recognized.
We then consider the problem of recognizing a convex polygon in 2D. We present an algorithm that takes at most 3n - 2 silhouette pictures to recognize a convex polygon with n sides. After establishing this we show that any algorithm will require at least 3n - 5 silhouette pictures in the worst case. We provide a scheme that recognizes a convex polygon in 2D using six nodules pictures.
We show that three x-ray histogram pictures are necessary and sufficient to recognize any polygon in 2D under a mild assumption. We present an algorithm that takes 2h + 6 nodules pictures to recognize polygons from certain class of nonconvex polygons in 2D, where h stands for the number of vertices of the convex hull of the object. After that we give a procedure that uses at most 3n + 6 nodules pictures and 6n finger probes to recognize objects from another class of nonconvex polygons in 2D.
We then consider the problem of recognizing a convex polyhedron in three dimensions. We develop an algorithm that uses at most 5f + v finger probes, where f and v stand for the number of faces (facets) and vertices of the polyhedron respectively. We provide another algorithm that takes at most 2v + f silhouette pictures for this problem. We show that four line drawings (photographs) are necessary and sufficient for the recognition of a convex polyhedron in 3D. In this work, we also compare and contrast these models in an attempt to develop a hierarchical ordering of models for gathering information.


The following essay was written in Stockholm, Sweden in the autumn of 2015 at Stockholm University. The purpose of this study is to explore the forms of multimodal communication that are used in th ...


There is general agreement that in pregnancy there are deviations in maternal acid-base state from what is regarded as normal in non-pregnant subjects. The description of acid-base changes which follows has been centred on labour, since it is at this time that the deviations are most marked. The experimental methods used have been described elsewhere (Fadl & Utting 1969a, b): arterialized venous blood was used throughout the investigation (Brooks & Wynn 1959) and results are presented only from women who were considered to have a normal labour. Except where otherwise stated, samples were taken in the time between uterine contractions. The results of the determinations of blood pH, Pco2 and base excess are shown in Table 1. It can be seen that in late pregnancy, in labour and immediately after delivery there is hypocapnia, metabolic acidosis and a slight rise in blood pH. The change in carbon dioxide tension can be regarded as primary and is due to active pulmonary hyperventilation which is probably hormone induced. The mean Pco2 is low in the last trimester of pregnancy but the standard deviation from the mean is no higher than it is in non-pregnant subjects; the mechanism controlling Pco2 functions with the same precision as it does in non-pregnant subjects but at a lower level. In the early first stage of labour the Pco2 is lower than it was in the last trimester and the tension remains much the same till the end of the first stage when it declines to reach its lowest level, a decrease which is statistically significant (P <001). During the second stage the Pco2 rises slightly. The form of analgesia used in the first stage of labour was found to have little effect on blood carbon dioxide tension (Fadl & Utting 1969a). There was little difference in the Pco2 of samples taken between and during uterine contractions at the end of the first stage of labour except in those patients who were using a self-administered analgesic apparatus (the Entonox). In these patients the Pco% between contractions was somewhat lower than in those not using the apparatus, and during contractions the Pco2 fell to very low levels (mean 24-4 mmHg, S.D. 4 0 mmHg). During the second stage the Pco. appears to rise as the patient makes expulsive efforts. The blood pH is highest at the end of the first stage of labour and the increase in blood pH between the beginning of the first stage and the second stage is statistically significant (P <001). In the second stage the blood pH declines somewhat. It is worth emphasizing that the blood pH in labour would be very high if it were not for the existence of the concomitant base deficit. The problem of the metabolic acidosis of pregnancy and labour is a perplexing one. The ultimate arbiter of acid-base state is the Henderson-Hasselbalch equation. The constancy of the composite constant pK1' in this equation has been questioned. An experimental determination of the constant in women in labour, however, showed no difference in the values obtained for the constant in blood taken from women at the end of the first stage of labour and blood taken from normal control subjects, the value obtained being 6-106 at 38°C in both cases (Fadl & Utting 1969b). This indicates that the maternal metabolic acidosis must be considered genuine and vindicates the use of such nomograms as those of Siggaard-Andersen (1962, 1963). The causes of metabolic acidosis are, first, gain of strong acid by the extracellular fluid and, secondly, loss of bicarbonate from it. The relevant possible causes of gain of strong acid are accumulation of the products of the incomplete metabolism of carbohydrate or of fat (giving a lactic or keto-acidosis respectively), and the accumulation of the inorganic acid products of normal metabolism (phosphate and sulphate) seen in azotmmic acidosis. Blood lactate and keto-acid concentrations were investigated using enzymatic methods (Boehringer, Mannheim). When control values obtained from non-pregnant subjects were compared with values obtained from women in labour no substantial increase in either lactate or keto-acids could be demonstrated. In the case of lactic acid concentrations in labour (27 cases) there was a slight increase in lactate in the second stage but the mean value in the second stage was only some 025 mEq/l above the control levels obtained from non-pregnant subjects. An increase in keto-acids (both hydroxybutyric and aceto-


The dynamic properties of five nutrient elements(N,P,K,Ca and Mg) and the interaction between various nutrient in leaves of Cinnamomun cassia plantation of 3 and 6 year-stand age were studied.The results showed that the concentration of five elements in leaves of Cinnamomun cassia were in the order of N KCaMgP,and the coefficient seasonally variability of Ca concentration was the biggest,followed by Mg and K,Mg and P were the smallest in leaves of Cinnamomun cassia.There were similar seasonal changes of nutrient elements concentration in leaves of Cinnamomun cassia plantation of 3 and 6 year-stand age,N was highest during bud flush(mid-March),and lowest in pre-dormancy(mid-December).P and K was lowest or lower during bud flush,and higher or highest during the first fast growing season(mid-June) or the second fast growing season(mid-September).Ca was lowest during the first fast growing season,and highest during pre-dormancy.Mg was lowest during bud flush,and highest during pre-dormancy.There was a significantly positive interaction between P and K in Cinnamomun cassia plantation,but significant antagonism between P and Ca.


The invention provides a surface sizing agent for corrugated paper as well as a preparation method and application thereof. The surface sizing agent for the corrugated paper comprises the following components in parts by weight: 100 parts of base stocks of the surface sizing agent for the corrugated paper and 5-10 parts of cationic additives, wherein the cationic additives are emulsified materials formed by stearic acids and cationic emulsifiers. The surface sizing agent for the corrugated paper is a high-performance environmental-friendly product which can meet the requirements for surface sizing of paper sheets; the product carries out the surface sizing on raw corrugated paper with starch together, thereby not only improving the Cobb value of the corrugated paper and accelerating the curing speed, but also greatly enhancing the surface ring crush strength of the corrugated paper and reducing the using amount of the starch; and in addition, the invention can be suitable for the needof the development of the high-strength corrugated paper.


Abstract : The objective of this project has been to retrieve useful seismic waveform data from an unwieldy format and create an easy-to-use data set for seismic research. The results are over 250 'event directories' for regional events in and near Iran. Each 'event directory' is a standalone data product including short-period seismic waveforms and CSS3.0 database tables containing the auxiliary information necessary and useful to read and interpret the waveforms. These data are available to interested researchers through an anonymous FTP account. The waveform data are from two seismic stations located in Iran and operating in the late 70's: The Iranian Long Period Array (ILPA), located near Tehran, and MMO, (Mashhad, Iran), located 800 km east of ILPA. Over 1700 phases were timed and identified on the ILPA and MAIO waveforms. This report focuses on how the data set was constructed and presents some analysis observations. An appendix lists the seismic bulletin summarizing all parameters related to each event. Information derived from this data set by researchers such as Sweeney, Baumgardt and Alexander and others, will certainly be critical to the understanding of propagation of regional seismic phases in and near Iran. Results based on the ILPA/MAIO should be part of the knowledge base currently being constructed by the DOE.


Optical rectification in organic crystals have proven to be an excellent material to achieve ultra-broad bandwidth THz radiation with high optical-to-THz conversion efficiency up to the percent level in simple collinear setups. However, so far, most results using organic crystals were restricted to low repetition rates, because of the generally accepted idea that these crystals have poor thermal properties. Only very recently the organic crystal HMQ-TMS was explored at MHz repetition rate showing mW-level THz average power [1] , [2] . Another promising crystal is BNA (N-benzyl2-methyl-4-nitroaniline), which has recently been used with a conversion efficiency of 0.8 % albeit at moderate repetition rate of 100 kHz [3] . Here, we demonstrate mW-class, high dynamic range, broadband THz generation in BNA crystal (Swiss Terahertz GmbH), driven by an ultrafast laser with MHz repetition rate. We obtain 490 µW of THz average power with a conversion efficiency of 5×10 -4 . To the best of our knowledge, this is the first time this material is investigated at high (MHz) repetition rate. To reach this efficiency, we use bursts of MHz-repetition rate driving pulses with variable duty cycle which can decouple the average power scaling from the pulse energy and allows us to disentangle the influence of average power, thermal effects, and peak intensity.


2566Background: Durvalumab is a human monoclonal antibody that binds to PD-L1 and blocks its interaction with PD-1 and CD80. The objectives of this analysis were to develop a population pharmacokinetics (PK) model of durvalumab, to quantitate the effect of patient/disease characteristics on PK, and to compare weight (WT)-based versus fixed dosing regimens. Methods: Data were pooled from two studies: Study 1108 (Phase 1/2; various tumor types) and ATLANTIC (Phase 2; NSCLC). A total of 1324 patients provided data following 0.1 to 20 mg/kg IV durvalumab. The population PK was performed using a non-linear mixed effects modeling approach in NONMEM software. The impact of demographics, clinical indices, and biomarkers on PK was explored. Results: Durvalumab PK was best described using a 2-compartment model with both linear and non-linear clearances. The mean (between-patient variability) linear clearance (CL) and central volume of distribution (V1) were 226 mL/day (~29%) and 3.51 L (~21%), respectively. Althoug...


This paper reports solubility measurements for unirradiated UO[sub 2] fuel at 2000, 2100, 2200, and 2300[degrees]C in initially oxygen-free Zircaloy-4 (Zr-4) and at 2100, 2200, and 2300[degrees]C in Zircaloy-4 with an initial 25 at.% oxygen content (Zr-4/25% oxygen); the latter alloy was used to represent the oxygen-saturated Zr-4 component of steam-oxidized cladding. The work was performed to determine the maximum extent of fuel dissolution that could occur at various temperatures during the high-temperature transient of a hypothetical reactor accident involving impaired cooling. These values could then be used to estimate the fractional release of the volatile fission product inventory, which, to a first approximation, would be proportional to the volume fraction of dissolved fuel.


The cell is the basic element of all organisms. Although it measures only a few micrometers in size, it has notable biological and organizational functions. The cell is a common examination topic in biology, biochemistry, and histology. This is because of its numerous organelles, cytoskeleton, and cell-cell contacts. This article discusses several topics related to cells, which are relevant for examinations.


The most recent upgrades of the electromagnetic (EM) physics "standard" and "low energy" sub-libraries of the general purpose Geant4 Monte Carlo simulation toolkit are described. These upgrades are relevant to different application domains including high energy physics, medical physics and space science. Validation results are presented and discussed.


This research is motivated by the emergence of the phenomenon of
competition among Internet cafes or Cybercafes. The development of an Internet cafe
is determined by the number of consumers who visit and use the Internet service at
the internet cafe. Consumer decision in choosing to use the services of an Internet
cafe is influenced by several factors, namely: the speed of access, the price per hour,
the completeness of existing support facilities, the professionalism of service
employees. In this study, authors tried to analyze the factors that influence consumer
decisions use the services of internet cafes, which includes variable access, price,
facilities, services, promotions.
This research was conducted using questionnaires to 100 people visitors
Internet cafes around Undip resurfacing obtained by using accidental sampling
technique. Then we performed an analysis of data obtained in the form of
quantitative and qualitative analysis. A quantitative analysis include validity and
reliability test, the classic assumption test, multiple regression analysis, Goodness of
Fit test through regression coefficient (R2), F test and t test Qualitative analysis is an
interpretation of the data obtained in this study, and results of data processing that
have been implemented with a description and explanation.
The results showed that all independent variables are tested has a positive
and significant impact on consumer decisions through F test and t test, whereas the
numbers Adjusted R Square of 0.537 indicates 53.7% customer satisfaction can be
influenced by service, location and internet cafes facilities, and the remaining 46.3%
is explained by other factors beyond this research.


Historical and recent advances of lanthanide mononuclear complexes, polynuclear clusters, coordination polymers (CPs) and metal–organic frameworks (MOFs) with temperature-dependent luminescence are reviewed for future thermo-sensitive paints.


Given the techno-scientific developments in the biomedical area, the human embryo was surrounded by different conceptions and interests. The objective of this paper is to outline an overview of existing conceptions of the human embryo, in the search of finding its moral statute. The different positions are based on scientific and philosophical arguments. The justifications for the consideration of the human embryo as a person are supported by the right to life and by moral values against the instrumentalization of the embryo. The opposite view claims that there are no ethical and metaphysical elements in the embryo and it cannot therefore be granted the status of human person to it. Despite irreconcilable conceptions, in the future these visions can be reinvented in a complex way in other socio-ecological contexts.


It is a brief summary of approximately 300 words. I t should include the research question, the rationale for the study, the hypothesis (if any), t he method and the main findings. Descriptions of the method may include the design, procedures, the sample and any instruments that will be used. Introduction: The main purpose of the introduction is to provide th necessary background or context for your research problem. How to frame the research pr oblem is perhaps the biggest problem in proposal writing. If the research problem is framed in the context of a general, rambling literature review, then the research question may appear trivial and uninte res ing. However, if the same question is placed in the context of a very focused and current r search area, its significance will become evident. Unfortunately, there are no hard and fast rules on how to frame your research question just as there is no prescription on how to write an interes ting and informative opening paragraph. A lot depends on your creativity, your ability to thi nk clearly and the depth of your understanding of problem areas. However, try to place your research question in the context of either a current "hot" area, or an older area that remains viable. Secondly, you ne ed to provide a brief but appropriate historical backdrop. Thirdly, provide the contempor ary context in which your proposed research question occupies the central stage. Final ly, identify "key players" and refer to the most relevant and representative publications. In s hort, try to paint your research question in broad brushes and at the same time bring out its si gnificance. The introduction typically begins with a general st atement of the problem area, with a focus on a specific research problem, to be followed by t he rational or justification for the proposed study. The introduction generally covers the follow ing elements: 1. State the research problem, which is often referred to as the purpose of the study. 2. Provide the context and set the stage for your rese a ch question in such a way as to show its necessity and importance. 3. Present the rationale of your proposed study and cl early indicate why it is worth doing. 4. Briefly describe the major issues and sub-problems to be addressed by your research. 5. Identify the key independent and dependent variable s of your experiment. Alternatively, specify the phenomenon you want to s tudy. 6. State your hypothesis or theory, if any. For explor at ry or phenomenological research, you may not have any hypotheses. (Please do not con fuse the hypothesis with the statistical null hypothesis.) 7. Set the delimitation or boundaries of your proposed r search in order to provide a clear focus. 8. Provide definitions of key concepts. (This is optio nal.) Literature Review: Sometimes the literature review is incorporated int o the introduction section. However, most professors prefer a separate section, which allows a more thorough review of the literature. The literature review serves several important func tions: 1. Ensures that you are not "reinventing the wheel". 2. Gives credits to those who have laid the groundwork f your research. 3. Demonstrates your knowledge of the research problem . 4. Demonstrates your understanding of the theoretical and research issues related to your research question. 5. Shows your ability to critically evaluate relevant literature information. 6. Indicates your ability to integrate and synthesize the existing literature. 7. Provides new theoretical insights or develops a new model as the conceptual framework for your research. 8. Convinces your reader that your proposed research w ill make a significant and substantial contribution to the literature (i.e., r esolving an important theoretical issue or filling a major gap in the literature). Most students' literature reviews suffer from the f ollowing problems: • Lacking organization and structure • Lacking focus, unity and coherence • Being repetitive and verbose • Failing to cite influential papers • Failing to keep up with recent developments • Failing to critically evaluate cited papers • Citing irrelevant or trivial references • Depending too much on secondary sources Your scholarship and research competence will be qu estioned if any of the above applies to your proposal. There are different ways to organize your literatur e review. Make use of subheadings to bring order and coherence to your review. For example, ha ving established the importance of your research area and its current state of development, you may devote several subsections on related issues as: theoretical models, measuring instruments, cross-cu ltural and gender differences, etc . It is also helpful to keep in mind that you are tel ling a story to an audience. Try to tell it in a stimulating and engaging manner. Do not bore them, because it may lead to rejection of your worthy proposal. (Remember: Professors and scientis ts are human beings too.)


2,3,6-Tri-O-benzyl-D-myo-inositol, which is a key intermediate of D-inositol 1,4,5-triphosphate, was synthesized from D-glucose without performing any optical resolution by utilizing C2 symmetry. Laminitol and mytilitol were also synthesized from D-glucose via the same key intermediate, 1D-(1,3/2,4)-tetra-O-benzyl-2-C-methyl-5-cyclohexene-1,2,3,4-tetrol.


Recent studies have highlighted the need to improve our understanding of the relationship between glacial- 15 front bathymetry and oceanography in order to better predict the behaviour of tidewater glaciers. The 16 glaciomarine fjords of western Svalbard are strongly influenced by temperate Atlantic Water advected from the 17 West Spitsbergen Current. Marine terminating (tidewater) glaciers locally influence many Svalbard fjords 18 through fluxes of sediments, nutrients and freshwater, however their response to ocean warming and the 19 imprint left by their recent retreat on the seabed remains unresolved. Here we present glacial front data 20 collected by an autonomous underwater vehicle (AUV) from four tidewater glaciers; Fjortende Julibreen 21 (Krossfjorden), Conwaybreen, Kongsbreen and Kronebreen (Kongsfjorden). The seabed adjacent to the glacial 22 terminus has been mapped providing high-resolution bathymetry (0.5m-1.0m grid cell size), side-scan and 23 photographs with additional simultaneous oceanographic observations. The aim being to survey the glacial 24 front submarine landforms, to identify the water mass structure and to observe any melt water plume activity. 25 The bathymetry data displays a diverse assemblage of glacial landforms including numerous retreat moraines, 26 glacial lineations, crevasse-squeeze ridges and sediment debris flows reflecting the dynamic depositional 27 environment of the glacial front. The age of the features and the annual rate of retreat have been estimated 28 using satellite remote sensing imagery to digitise the glacial front positions over time. The glacial landforms 29 have been produced by the last few years of retreat as these glaciers gradually become land-terminating. The 30 AUV also observed in-situ subglacial meltwater plumes at the two most active glaciers (Kongsbreen and 31 Kronebreen) and an associated signature of warm Atlantic Water occurring at the glacier face. The presence of 32 relatively warm, oceanic waters enhances subsurface melting, accelerating the ablation rate, while fresh (melt) 33 water injection at depth influences local water mass structure and the wider fjord circulation. At the glacial 34 fronts of Kongsbreen and Kronebreen sedimentation from subglacial meltwater plumes dominate the ice- 35 proximal zone and settling from suspension is more prevalent away from the glacier. This study shows how 36 sensitive dynamic glaciomarine systems are to change in the local marine environment and how the use of 37 autonomous vehicles can greatly aid in the monitoring of glacial change by collecting simultaneous high- 38 resolution in-situ datasets where vessel based observations are lacking. 39


THE ECONOMIC CO-OPERATION ADMINISTRATION, in connection with its efforts to promote the exports of the Marshall Plan countries to the United States and thereby lessen their need for dollar aid, engaged a consultant to prepare an analysis of the financing of these exports. The Department of Commerce co-operated in this study through interviews of personnel in its I7 field offices with importers, bankers, warehousemen, foreign-trade zone authorities, factors, and dealers in foreign exchange to ascertain the methods of import trade financing currently utilized and to sample opinion concerning the adequacy of these methods. The principal results of this survey may be summarized as follows: I. The United States as an international finance center.-Although the dollar is today the world's leading international standard of account and medium of exchatnge, the American foreign trade financing market lacks the breadth, depth, and flexibility of the London market of pre-World War II days. There is less variety in the institutions engaged, and the instruments employed, in foreign trade financing. The devices currently employed were held, by the large majority of those interviewed, to be adequate for the financing of routine, standardized transactions. The financing of the novel transaction-the import business requiring medium-term capital, foreign area development, and the extension of American enterprise abroad-was less adequately met. 2. Dominance of the commercial bank.-Most of our import financing transactions are handled by commercial banks. The services which these banks render in this connection were widely regarded as satisfactory and their charges, interest and other, as reasonable. Many of these banks have well-staffed foreign trade departments, equipped to render service and advice to foreign traders. Some of those interviewed expressed the opinion that banks could place greater emphasis


In the single-arm, multicenter, phase II part of the CAVALLI trial, the researchers analyzed the efficacy of 800-mg venetoclax plus R-CHOP in all first-line DLBCL patients.


A number of photodetector assemblies were constructed and evaluated for their suitability in an optical fiber attenuation measurement system operating in a production environment. The assembly exhibiting the best compromise among the critical performance parameters utilized a PIN photodiode with an achromatic lens assembly. This compromise required a trade off between measurement accuracy and the overall versatility of the photodetection system.


Labor induction can be lengthy and expensive, a particular concern for hypertensive women in developing countries; hence, optimizing the efficiency of


A method (10) for reducing or eliminating the effects of proximate samples on the NMR measurement of the mass of a test sample in a NMR check weighing system (24) for samples on a production line. The test sample is in a container (22) on a production line with the plurality of proximate samples each also in a container (22) on the production line. Method (10) includes determining cross coupling weighing factors for a plurality of samples in proximity to the test sample, magnetic resonance measuring of the test sample and proximate samples, the step of magnetic resonance measuring of the test sample and proximate samples providing data representative of each measurement; and applying weighing factors to the data representative of each measurement compensating for the proximate sample effects. ® KIPO & WIPO 2007


A plane static problem of elasticity theory is considered for the case when the domain where solution is sought can be partitioned into arbitrary quadrangular elements. An approximation is constructed with the deformations constant within the element. When the domain is partitioned in quadrangular elements this is possible when two approximating functions are used for the shifts. The euations of the element rigidity are formulated on the basis of the quadratic approximation, the conditions are given when both rigidity variants coincide. The problem solution for the assumed approximation is reduced to the solution of the system of algebraic equations. The solvability of the equation of elements unification (join) is proved as well as the extremal property of the solution of the elements unification equation and, the solution convergence to the exact solution.


Interrupted time series analysis (ITSA) is a statistical procedure that evaluates whether an intervention causes a change in the intercept and/or slope of the time series. However, very little research has accessed causal learning in interrupted time series situations. We systematically investigated whether people are able to learn causal influences from a process akin to ITSA, and compared four different presentation formats of stimuli. We found that participants' judgments agreed with ITSA in cases in which the pre-intervention slope is zero or in the same direction as the changes in intercept or slope. However, participants had considerable difficulty controlling for pre-intervention slope when it is in the opposite direction of the changes in intercept or slope. The presentation formats didn't affect judgments in most cases, but did in one. We discuss these results in terms of two potential heuristics that people might use aside from a process akin to ITSA.


Background: Temporomandibular dysfunctions present a multifactorial etiopathogenesis that require a multidisciplinary approach in which the rehabilitation performed by physiotherapists assumes a role of primary importance. Despite the high number of publications, the studies observed purely in the physiotherapeutic field are in a very low percentage. Methods: To this end, a literature search was conducted on the Pubmed database, using three key words: "Mandibular temporal Joint rehabilitation", "Physical therapy temporomandibular", "Rocabado" and "Physical therapy". The total number of items identified is 1594, of which 40 were deemed relevant to the research through the review process.Results:After examining the selected studies, the most effective management of temporal mandibular dysfunctions appears to be the conservative approach that includes non-thrust joint mobilization and HVLA thrust manipulation to the TMJ and / or upper cervical articulations, and dry needling or acupuncture to the lateral pterygoid muscle and posterior periarticular connective tissue. Conclusion:Through such therapeutic modalities it is possible to have an impact on the anatomical structures directly connected to the etiology of the dysfunction.


Objective To observe the therapeutic effect of "Dong's Kaiwei Powder" on acupoints and pricking Sifeng(EX-UE 10) in the treatment of infantile anorexia.Methods 102 cases of infantile anorexia were treated with "Dong's Kaiwei Power"on acupoints and pricking sifeng points,with a course of one month.Results Among 102 cases,19 cases were cured,81 cases were markedly improved,2 cases failed,and the total effective rate was 98.04%.Conclusion "Dong's Kaiwei Powder" on acupoints and pricking Sifeng points is quite effective for infantile anorexia.


We compute the logarithmic corrections to the black-hole (BH) entropy product of ( and denote outer (event) horizon and inner (Cauchy) horizons) by using Cardy prescription. We particularly apply this formula for BTZ BH. We speculate that with the logarithmic corrections to the entropy product of when computed via Cardy formula the product should be neither mass independent (universal) nor be quantized.


Fifty-nine poems of Gao Gong were collected in his Miscellaneous Writings.Among them,the writing date or relevant historic events of 28pieces can be roughly determined.These poems reflect Gao Gong's psychological changes as an government official.


The conversion of a series of pharmaceutical compounds was examined with three variants of cytochrome P450BM3 fused to phosphite dehydrogenase (PTDH) to enable cofactor recycling. Conditions for enzyme production were optimized, and the purified PTDH–P450BM3 variants were tested against 32 commercial drugs by using rapid UPLC–MS analysis. The sets of mutations (R47L/F87V/L188Q and R47L/F87V/L188Q/E267V/G415S) improved conversion for all compounds, and a variety of products were detected. Product analysis showed that reaction types included C‐hydroxylation, N‐oxidation, demethylation, and aromatization. Interestingly, enzymatic aromatization could occur independent of the addition of reducing coenzyme. These results identified new conversions catalyzed by P450BM3 variants and showed that a small set of mutations in the oxygenase domain could broaden both substrate range and reaction type.


Vesicles, including nucleic acids and proteins, compositions for nucleic acid and A Sister proteins simultaneously delivered to a cell. Wherein the nucleic acid comprises at least one epitope A Sister protein antigenic protein or portion thereof shared by functionally encoding, composition, the nucleic acid and the A Sister protein in association with each other and the same vesicle. Preferred embodiment, the liposomes formed from liposome forming materials, in association with liposomes, a composition comprising a nucleic acid and A Sister proteins functionally encoding an antigenic protein. In this case, A Sister protein at least one epitope shared with antigenic protein. The compositions of the present invention is intended to be used as a vaccine, the composition of the non-follicular, or partially associated with nucleic acids and partially in comparison with a mixture of liposomes in association with A Sister protein, It provides improved immune response.


Because of its enigmatic character North Korea is known as the "hermit kingdom." There is little literature on North Korea's criminal...


Ordered Binary Decision Diagrams are a data structure for representation and manipulation of Boolean functions often applied in VLSI design. The choice of the variable ordering largely influences the size of these structures, size which may vary from polynomial to exponential in the number of variables. A genetic algorithm is applied to find a variable ordering that minimizes the size of ordered binary decision diagrams as a practical alternative to exact algorithms for variable ordering.


【Objective】 The research was conducted to explore the relationship between soil factors and arbuscular mycorrhizal and glomalin.【Method】 Six sampling plots were chosen on the Loess Plateau in Shaanxi.Soil sampling(5-30 cm depths) in the rhizosphere of Sophora davidii was collected using five points sampling method.The spatial distribution of mycorrhizae colonization,spore density and glomalin in the rhizosphere of S.davidii and their relationships with soil factors were investigated on the Loess Plateau.【Result】 AMF colonization was up to 74.42% on average,the spore density averaged 19.06 per gram soil and the regional difference was significant,but the rate of AMF colonization was not correlated significantly with the spore density.The mean of glomalin total was 2.32 mg/g,accounting for 36.46% of soil organic carbon.The distribution of spore density and glomalin presented spatial heterogeneity.Glomalin was related with soil organic carbon,available N and Olsen P(P0.01),and negatively correlated with pH.Meanwhile,it was remarkably correlated with soil enzyme activities.【Conclusion】 Our results showed that the soil factors were strongly correlated to AM fungi,and the AMF spore density and glomalin were useful indicators for the building and perfecting of index evaluation system.


Aim: The aim of this study is to investigate how an organization which is based on ethic and social responsibility works with segmentation, positioning and brand. Do their specific need of credibil ...


Although diffusion probabilistic vocoders WaveGrad and DiffWave can realize real-time high-fidelity speech synthesis with a simple loss function in training, all noise components with over the full range of noise levels are predicted by one model in all iterations. This paper proposes a simple but effective noise level-limited sub-modeling framework for diffusion probabilistic vocoders Sub-WaveGrad and Sub-DiffWave. In the proposed method, DiffWave conditioned on a continuous noise level like WaveGrad, and spectral enhancement post-filtering are also provided. The proposed Sub-WaveGrad and Sub-DiffWave models are realized using 10 sub-models. These models are separately trained with different noise level limits, and only necessary sub-models are used according to the noise schedule during inference. The results of experiments using a Japanese female speech corpus indicate that both the proposed Sub-WaveGrad and Sub-DiffWave outperform vanilla WaveGrad and DiffWave in terms of the model accuracy and synthesis quality while retaining the inference speed.


The ability to monitor cellular processes at high resolution using genetically encodable fluorescent protein tags and sensors has revolutionized life science research. In particular, several super-resolution imaging techniques take advantage of the phenomenon of stochastic fluorescent protein blinking. Here we present a method for measurement and analysis of the blinking behavior of red fluorescent proteins. This project contributes to the characterization of crucial photophysical parameters of fluorescent proteins used for super-resolution imaging techniques.


When do judges initiate public action outside the courtroom? What kinds of political activities do they engage in? What are the consequences of their interactions with social and political actors? This article investigates judges' efforts to influence law and policy as opinion leaders, protesters, and network builders. In light of recent devevelopments in Turkey, I argue that intrajudicial conflict, that is, the increasing salience of hitherto dormant tensions inside the judiciary, is the primary source of off-bench judicial mobilization. Participants in off-bench judicial mobilization seek to maintain, reform, or transform judicial institutions in ways that enhance their ideational and strategic goals.


Objective To explore the distribution of cytokeratin segment 1 9 (CYFRA21_1)and neuron-specific enolase (NSE )in the occupation crowd and the effect on the lung cancer screen and provide the clue for lung cancer screening in the large scale population. Methods CYFRA21_1 and NSER kits were used to test the serum from employees of the authority units,institutions and enterprises for health check in Guangming District between January and December 2014. Results The distribution was not normal for CYFRA21 _ 1 (D K-S =0.09,P <0.01)and NSE(D K-S =0.09,P <0.01)with the media of 1.92 ng/ml and 12.5 1 ng/ml, respectively for them.In the age subgroup,the distribution of all the subgroups of the NSE and CYFRA21_1 was not normal except the 5 1~60 age group of NSE (13.77±2.88 ng/ml).And the different distribution were statistics in the gender for the CYFRA21 _ 1 (Z = - 4.10,P < 0.01 )and NSE (Z = - 9.03,P < 0.01 ). 10.12% (234/231 1)and 9.26 %(214/231 1)of all participants had abnormal results for NSE and CYFRA21_1 and the proportion were 0.43% and 0.47% of them with the diagnosis of the relative cancer. Conclusion Although CYFRA21_1 and NSE are certified to be important biological markers in the diagnosis of lung cancer, it is also questionable for applying them for lung cancer screening in normal and high risk population because of their low specificity and large different expression in the population.


As Dr. Jackson 1 mentioned in his book on peroral endoscopy, the esophagus is surgically the most intolerant organ in the body. In cases of septic mediastinitis the general surgeon should be consulted, though unfortunately most cases are hopeless. Jackson further stated that a foreign body lodged in the esophagus may quickly prove fatal from hemorrhage, asphyxia or perforation and septic mediastinitis. I shall present six cases of mediastinitis following foreign body, as I trust they will bring about discussion. In two of the six cases I performed esophagoscopy when mediastinitis was already present ; both patients died. In two cases in which there was mediastinitis no endoscopic procedure was done; both patients died. In one case, the point of a safety-pin had perforated, but the pin was sufficiently close to the stomach so that it could be removed from below, which was done, with the earnest request that a gastrostomy


Now there exist three kinds of viewpoints on financial supervision. One thinks our country should relax financial supervision, other thinks that our country should strengthen financial supervision; the 3rd viewpoint thinks financial supervision should be flexible. This paper thinks the discrepancy of these viewpoints lies in the different object that they discuss. Actually these viewpoints are compatible.


The current study was carried out to assess the in vitro antioxidant properties of various extracts of stem and leaf parts of Pachygone ovata and to analyze its secondary metabolites. Hexane, petroleum ether, chloroform and ethanol were used as extraction solvents and are employed for phytochemical screening. Antioxidant assays were evaluated by assessing DPPH radical scavenging assay, nitric oxide radical inhibition activity and reducing power activity. Phytochemical analysis of the extracts of P. ovata indicated the presence of various types of compounds. Among the tested solvent extracts, hexane and chloroform reported maximum yield. In in vitro antioxidant activity, chloroform extract of stem, on DPPH and Nitric Oxide showed a greater scavenging effect as well as high reducing potential when compared to other solvent extracts. From this study, it can be concluded that the secondary metabolites and antioxidant nature of the compounds present in the plant material can be used to invent new drugs of antioxidant properties of natural origin.


The study presented in this paper analyzed four long-term pavement performance (LTPP) test sections located in the states of New York (NY) and California (CA). Two of them are flexible pavement sections, whereas the other two are composite pavement sections. Two levels of analysis—in-state analysis and cross-state analysis—were performed for these pavement sections to determine the impacts of traffic and climate conditions. The performance of the pavement sections was evaluated in respect of thermal cracking and rutting resistance. The in-state analysis focused on comparing the pavement sections located in the same state. The two pavement sections located in CA exhibited insignificant variation in thermal cracking, although one of them had an additional 1.5" (38 mm) dense-graded asphaltic concrete (AC) layer. On the other hand, the additional 1.5" (38 mm) AC layer resulted in a significant reduction in the rutting depth in one pavement section. The in-state analysis of the two pavement sections located in NY revealed that the 0.8" (20.4 mm) chip seal layer had significantly low resistance to thermal cracking and rutting. The cross-state analysis examined pavement sections of comparable structural capacities—two with low structural capacity, and two with high structural capacity. The performance comparison of the two pavement sections with low structural capacity revealed that the chip seal layer exhibited a significantly high rutting depth, i.e., low rutting resistance under high traffic loads in a freezing climate. On the contrary, the two pavement sections with high structural capacity showed relatively high rutting resistance in both warmer and freezing climates. Furthermore, this paper presents the pavement deterioration models for rutting and thermal cracking in the LTPP test sections. These models were developed using multiple linear regression considering the pavement service life (age), traffic load (average annual daily truck traffic, AADTT), and climate impact (freezing index, FI). The deterioration models had coefficients of determination (r2) in the range of 0.82–0.99 and standard errors varying from 0.01 to 9.92, which indicate that the models are reliable.


An assembling bridge inspection bar is provided to install and disassemble easily by assembling the inspection bar with a post, to cut down repairing cost by partly repairing and replacing the inspection bar, and to protect the post by surrounding the post with the inspection bar. An assembling bridge inspection bar(600) includes plural main frame parts(100) spaced from each other and arranged longitudinally to a post, a sub frame part(200) vertically combined with the main frame part arranged at both ends of the post, a couple of lower frame parts combined with the main frame parts at both lower parts of the post, an inspection path unit(400) combined with the main frame part and the sub frame part to form an inspection path at a side of the post, and an inspection stair(500). The main frame part includes an upper horizontal frame, a lower horizontal frame, a first vertical frame, a second vertical frame, a scaffold support bar and a support, and surrounds the post. Buffer members(170) are formed in contact portions of the upper or lower horizontal frame and the first or second vertical frame and the post to protect the post and to relieve shock.


This paper studies the unhealthy tendency in the contemporary literature circle such as subjectivism,secratianism,bureaucratism at the initial stage of establishment of People's Republic of China.It also analyses the reasons and the harm to the contemporary literature.


The article focuses on the specificity of the behavior of modern prosumers in the market for organic products as a determinant of sustainable consumption. The strengthening of the pro-consumer relationship is made possible thanks to ongoing technological changes, especially the development of the Internet. It is thanks to our online activities and the opinions of other Internet users that pro-consumer decisions concerning online purchases are shaped. The article presents the results of empirical studies conducted in 2020 on a sample of 664 respondents using a questionnaire, while the survey results were developed using SPSS Statistics. Findings of research showed the willingness of consumers for prosumption and kind of behaviors that were most often among the research group. In the course of research proceedings, it was possible to define factors that dispose declarative prosumers for the purchase of organic products. Conducted analyses also allowed for building the model of the influence of individual characteristics of respondents on the index of prosumption.


[Objective]To explore a new therapy for postoperative non-union of humerus shaft. [Method] Thirty-seven cases of non-union after internal fixation operations of humerus shaft fractures were treated with unilateral external fixators combined with bone graft. All cases were followed up for 2 years and the results were analyzed. [Result] All fractures knitted well and joint function resumed to normal. No complication was found. [Conclusion] Unilateral external fixator combined with bone graft is an effective therapy for postoperative non-union of humerus shaft fracture. Its clinical application is being expected.


Although there is a growing trend to use higher strength for concrete and steel in reinforced concrete structures due to the lightness and slenderness of these members together with the simplified arrangement of their reinforcement, there is still the necessity to inspect the reduction of ductility resulting from the gain in strength. Taking into account that this also concerns the design for torsion, this study intends to investigate the regulations related to the torsional minimum reinforcement ratio in view of the minimum ductility requirement with focus on Eurocode 2. To that goal, the relation between the torsional cracking moment and the ductile behavior is discussed for the beam reinforced with the minimum torsional reinforcement ratio to examine the eventual properness of the minimum torsional reinforcement ratio recommended by Eurocode 2. Moreover, a pure torsion test is performed on 18 beams made of 80 MPa concrete reinforced by high-strength bars with rectangular section and various test variables involving the minimum torsional reinforcement ratio, the transverse-to-longitudinal reinforcement ratio, and the total reinforcement ratio. As a result, for the high-strength concrete beams, the minimum torsional reinforcement ratio recommended by Eurocode 2 was insufficient to prevent the sudden loss of strength after the initiation of the torsional cracking. But with regard to the compatibility torsion of statically indeterminate structure, the adoption of the minimum torsional reinforcement ratio recommended by Eurocode 2 might secure enough deformability under displacement-controlled mode to allow the redistribution of the torsional moment.


Influence of four plant geometries and three nutrit ion doses on seed quality parameters during storage was studied using Sweet corn cultivar Madhuri in a Randomized bdesign with factorial concept. The analysis of bimonthly data on seed storage potential after six months ind icated significant influence of storage period on a ll the five seed quality parameters evaluated. The interaction effec ts between storage, plant geometry and nutrition do ses were also highly significant. Marked decline in germination percentage, seedling dimensions and corresponding vigour index was noticed over a period of six months. However, g ermination percentage did not go below 90 per cent which is much above the minimum seed certification standard of 80 per cent. The study also indicated that shoot length was the most sensitive seed quality parameter affected by ageing due to storage under ambient conditions. The study revealed that the superior combinations for yield a nd yield components also performed desirably for s quality attributes indicating better storage potential unde r ambient conditions. In this context, treatment c ombinations viz., 45 x 20 cm /120:60:45 NPK kg ha -1 , 60 x 15 cm / 150:75:45 NPK kg ha -1 , 60 x 20 cm / 120:60:45 NPK kg ha -1 , 60 x 20 cm / 150:75:45 NPK kg ha -1 performed better at the end of six months of stora ge in terms germination and


The "documentos" (p. 41-109) consist of the despatches, twenty-three in number, from King John III of Portugal to his ambassador at the French court, D. Antonio da Ataide


There is a contradict findings on the effect of placenta abruption on the risk of intrauterine growth restriction (IUGR). Therefore, the objective of present meta-analysis was to identify all the eligible studies to assess the effect of placenta abruption on the risk of IUGR. The major electronic databases, including PubMed, Scopus and Web of Science, were searched to identify relevant published studies. The literature search included 551 articles until January 2018 with 35,201 participants. In the end, a total of seven references were remained for this meta-analysis. Two independent authors reviewed the retrieved the studies and extracted data. I2 statistics was used to assess of heterogeneity. The random effects model was conducted to assess pooled effects size. the results of study showed that placenta abruption has a significant effect on the risk of IUGR based on odds ratio results (2.06; 95% confidence interval: 1.57, 2.55). The result reported of the measure of effect was homogeneous (I2 = 0.0%). we presented based on reports in epidemiological studies that placenta abruption is a risk factor for IUGR.


ABSTRACT This study is based on the opinions of selected Iraqi extension workers, regarding the type and amount of training they need, given their experience in the field. The Borich Needs Assessment Model was used for measuring training needs. The data were collected through questionnaires given to 300 respondents (agricultural workers) from January 15, 2016 to March 20, 2016. The results show that crop-planting courses have the greatest benefit. The greatest training need is skill and knowledge of teaching methods, while a moderately needed skill is the use of computer and information and communication technologies (ICT); management skills are the least needed training.


The paper presents the results of a series of monotonic and cyclic triaxial tests carried out to study the influence of the rate of strain and load cycles on the undrained shear strength of three undisturbed sensitive clays from eastern Canada. For structured clays (naturally overconsolidated), pore pressures generated at a given deviator are essentially independent of the strain rate, while the peak strength envelope is lowered as the strain rate is decreased. For destructured clay (normally consolidated), a lower strain rate results in an increase in pore pressure generation during shearing, due to the tendency of the clay skeleton to creep, while the peak strength envelope remains the same. Nevertheless, from a quantitative standpoint, the increase in shear strength caused by an increase in strain rate is similar for both structured and normally consolidated clay, and it is linear for at least five log cycles of strain rate.


Background: The purpose of this study was to investigate the specificity of metastatic mucinous colorectal cancer in terms of chemotherapy response and overall survival compared with non-mucinous colorectal adenocarcinoma.Methods: Twenty-nine mucinous-type and eighty-seven non-mucinous colorectal cancer patients were included after matching for age, sex and Duke's stage. Factors associated with chemotherapy response rate and overall survivals were evaluated by univariate Kaplan-Meier analyses or multivariate Cox regression model.Results: The overall response rates for mucinous and non-mucinous cancers were 33% and 58% (p=0.128), respectively. After adjusting for confounding factors, mucinous type was an independent factor to determine efficacy of chemotherapy (risk ratio, 0.15). The median overall survivals in mucinous and non-mucinous tumors were 8 months and 20 months, respectively (p=0.037). In multivariate analysis, mucinous histology was associated with poor prognosis (hazard ratio, 1.899, p=0.045). Conclusions: Metastatic mucinous colorectal cancers were less responsive to chemotherapy and had reduced survival in comparison to non-mucinous colorectal cancers.


Long-term, declining fertility is a reported trend in high-production dairy herds. Nutrition management is identified as a key area where improvement is required. Most published literature relating to nutrition management of dairy cow fertility examines energy and protein status and peri-parturient calcium (Ca) homeostasis availability. This paper examines the current understanding of Ca homeostasis relevant to improving performance in the high-production dairy herd. In particular, this article reviews Ca and vitamin D nutrition during lactation, for achieving health and productivity improvements in subsequent lactations, with specific reference to pasture-based dairy herds. Vitamin D metabolites are essential for increasing the proportion of absorbed Ca when dietary Ca concentration is low or when the requirement for Ca is high. Vitamin D metabolites stimulate the synthesis of the proteins that control active intestinal Ca absorption. This has particular relevance to cows that may not be able to replenish Ca reserves before parturition, which may be a common occurrence in current pasture-based dairy systems. It is possible that due to reductions in Ca reserves, the effectiveness of the cow to liberate sufficient Ca into plasma at parturition will be compromised as she faces subsequent lactations. This has significant implications for the ability of the cow to progress through transition in a healthy state, maintain an optimum energy balance during early lactation and subsequently conceive. Suboptimal nutritional management of Ca status through successive lactations may be shortening the productive life of the high-producing dairy cow.


The ancestral knowledge, are part of the development of an integral life, are in charge of transmitting through parents and grandparents. Childhood, which is always accompanied by adults, is an important stage to strengthen the psychic and emotional development through the learning of this knowledge, making reference to the enrichment of our culture. For this reason, the research project entitled "Rescue of ancestral knowledge of medicinal plants in the" La Luz "enclosure, canton Palenque" was developed, with the main objectives being the diagnosis of the current situation of ancestral knowledge of the "La Luz" enclosure. Make an inventory of the medicinal plants present and design an informative guide. The development of the present investigation was carried out in the aforementioned enclosure. The research project had the purpose of determining the types of medicinal plants and their use, as well as to make known the curative value of the medicinal plants found in the study area. This material will serve to socialize the community about the properties that medicinal plants have for human health, making this practice be maintained in some families from generation to generation. The methodology used for the development of this project was based on the collection of information registered and provided by the population of the enclosure, with which a diagnosis was generated, which resulted in: the majority of the knowledge of the use of medicinal plants is defined in people over 80 years of age, and that, in most respondents, it is the female gender that dominates the issue. Among the species recorded, aloe was the one that was named the most due to its various medicinal uses. The information provided was used to carry out the inventory and the informative guide.
Keywords: Information Guide, inventory, medicinal plants


The dynamic behavior of a fully stabilized superconducting composite is studied by observing terminal voltages V, temperatures T, and magnetic fields Hb as a function of transport currents I without an applied magnetic field. The current sharing in the resistive state of the composite is confirmed by measuring Hb in the vicinity of a composite in which superconducting filaments are arranged in a special configuration in a copper matrix. An observed I‐Hb diagram agreed well with that calculated from a fraction of the current sharing obtained from analyzing an observed I‐V diagram, under an assumption which regarded the composite as a parallel circuit composed of superconducting filaments and a copper matrix. In the resistive state, it was confirmed that the current in filaments exceeded the critical current of the bare filaments and the differential resistance of the composite was smaller than the resistance of the copper matrix.


Silybum marianum is the scientific name of milk thistle. For centuries, it is used to treat hepatitis, cirrhosis, jaundice, diabetes, and indigestion. The bioactive agents of milk thistle contain Apigenin, silybin, betaine, free fatty acids, silybin, silychristin, and silidianin. Objective: To determine the potential of Silybum marianum (milk thistle) in non-alcoholic fatty liver disease patients. Methods: It was a cross-sectional and experimental based study with NAFLD patients. A significant age range of 30 to 60 years was chosen for the 40 patients (20 men and 20 women). Screening period after liver biopsies (before and after the use of one capsule of S. marianum (Silymarin Standardize milk Thistle 300mg/day metabolic maintenance). Ultrasound technology assessed the liver condition at the start of the study and after the herbal 6-months therapy. Results: Out of 40 patients, 10 (25%) had hyperlipidemia and 5 (12.5%) were diabetics. The results of the 6-month therapy research study showed that the blood AST and ALT levels of NAFLD patients had significantly decreased. The average ALT and AST baseline concentrations were 85 and 65.9IU/ml, respectively. AST value (before and after therapy) showed a statistically significant difference in 80% of the NAFLD patients treated with S. marianum (32 out of 40; p=0.007). With a p-value of 0.05, alanine transaminase (ALT) normalization of disease severity was accomplished in 65% of patients (26 out of 40 patients). Conclusions: The therapy of NAFLD via S. marianum is successful in terms of biochemical improvement, especially when other medications have failed or when used in conjunction with other therapeutic techniques


By analyzing and comparing the monitoring data of the electromagnetic environments around four typical 110 kV transformer substations,we conclude that the power frequency electromagnetic field intensities are all far lower than the recommended limits(power frequency electric field intensity 4 kV/m and magnetic fiild intensity 0.1 mT) in the national standards.In addition,the shielding effect of the substation structures on power frequency electric field is remarkable.This study may provide a reference for planning and designing future transformer substation in city.


For the prevention of global warming and the improvement of quality of steel products, Kawasaki Steel has developed a regenerative burner and heating technologies by the use of regenerative heat exchanger system. A regenerative radiant tube burner was developed first. A direct-fired regenerative burner heating system was developed and applied to a reheating furnace for a wide flange beam mill, which was the first application for a large scale industrial furnace in the steel industry in Japan, and it has spread to reheating furnaces for hot strip mills, plate mills and seamless pipe mills. A non-oxidizing heating system using high temperature nitrogen jet, a ladle heating system synchronized with the steelmaking converter operation, and a rotary regenerator adopted heating system were also developed. These systems were applied to tundishs of continuous casting machines, to steelmaking converters and to continuous annealing lines respectively. Total energy saving of 733 924 GJ is achieved, that is equivalent to 94 513 t of CO 2 reduction a year, and improvement of steel product quality was achieved as well.


Spinal cord injury (SCI) is usually caused by a physical factor, especially like burs t fracture. Its primary phase involves displacement and physical accidents for the spinal cord, which have two factors of depth and speed of impact. In this phase, mos t damaged cells are oligodendrocytes in white matter. The secondary phase involves a cascade of cellular and molecular events that progresses rapidly and can cause neuroinflammation.in this phase, The leukocytes and microglians that are in injured region, accelerating the development of neuroinflammation by making unknown species of oxygen reactions. Our goal is to inves tigate the factors that reduce or improve neuroinflammation. Immunoglobulin G can decrease the activity of leukocytes and microglians and rate of neuroinflammation. Also, the use of useful antioxidants can be effective in reducing neuroinflammation. It seems that presence of immunoglobulin G with an antioxidant can reduce the amount of neuroinflammation caused by SCI seriously. For example, research has shown that combination of palmitoylethanolamid (an endogenouse lipid-neuroprotection) and luteolin (anti-oxidant) can reduce neuroinflammation.also,Ethanol is extracted from black chokeberry (Aronia melanocapa L.) has anti-inflammatory effects. Other s tudies have also shown that transplantation of bone marrow mesenchymal s tem cells (BMCs) and cerebral dopamine neurotrophic factor can inhibiting the process of neuroinflammation and decearse production of proinflammation.in addition,it can be effective in regenerating and repairing damaged neurons in SCI. Perhaps a combination of s tem cell transplantation and antioxidant effects can help to prevent the development of neuroinflammation and regeneration damaged neurons.


Problem based learning and teamwork activities often turn out to be the student's first point of contact with what Industry is really like and becomes a fundamental milestone in their learning throughout their degree course. The complete development of products and machines provides opportunities for active learning projects where students can apply computer aided design, engineering and manufacturing technologies, as well as the most advanced rapid prototyping technologies, so highly valued by Industry. We present complete product developments that have been undertaken by teams of students, as a way to the practical application of design and manufacturing concepts acquired in the subject "Design and Manufacture with Plastic Materials." This subject is taught in the 5th course at Universidad Politécnica de Madrid—U.P.M. as part of the Mechanical Engineering Degree. The use of the "Rapid Prototyping Technologies" available in the U.P.M.'s Product Development Laboratory, has enabled prototypes to be manufactured, which means the pre‐production stage has been attained. The use of these technologies for teaching purposes constitutes a whole new experience in the U.P.M. Important information for improvements has been obtained from students' surveys and the correspondence between students' dedication and the European Credits assigned to the subject is very satisfactory. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 661–668, 2010; View this article online at wileyonlinelibrary.com; DOI 10.1002/cae.20270


the absorption spectrum of antirachitic cholesterol. A monochromator with double spectral resolution was employed in conjunction with a photoelectric photometer. The presence of three absorption bands which disappear on irradiation is confirmed and the absorption curve for inactive cholesterol is found to be quite smooth. The photoelectric method, using mono-chromatic light, thus establishes our view that no change occurs during the measutement of absorption spectra by the photographic method, and our


Telepsychiatry is the use of telecommunications in remote assessing and treating psychiatric patients. This paper introduces the applications and progress of telepsychiatry in clinics, hospital emergency rooms, home-based assessment and treatment, and medical services for students. The applications of computer game and virtual reality in telepsychiatry is also presented. New initiatives of implementing telepsychiatry in the Mississippi Delta, USA is proposed and discussed. The new initiatives cover telepsychiatry services in mental health clinics, hospital emergency departments, tele-monitoring at home, and junior/senior high schools.


New data from two sites in the municipality of San Blas, Nayarit, indicate that the practice of pecking petroglyphs in West Mexico is older than it has been possible to establish in previous studies. Petroglyphs at the La Coba site appear firmly dated to the Los Cocos phase (A.D. 200-600), and petroglyphs at the El Conchal site seem attributable to the Early Ixtlan phase (300 B.C.-A.D. 200) occupation. Hypotheses are offered regarding stylistic evolution of the pecked designs and their interpretation.


In multirate processing, it is often necessary to understand how the statistical properties of signals (such as stationarity) are altered by passage through multirate systems. Some of these issues have been addressed previously by Sathe et al. (1993). For example, it has been shown that a necessary and sufficient condition for the output of an L-fold interpolation filter to be wide sense stationary (WSS) for all WSS inputs, is that the filter have an aliasfree (L) support. However, this result was established using conventional tools such as polyphase matrices, which resulted in a convoluted derivation which does not provide much insight. It also leaves many questions unanswered, since it does not generalize easily to the case of systems with vector inputs. This paper shows that problems of this nature can be addressed in an elegant and insightful manner by using bifrequency maps, and bispectra. In particular, we give a simpler proof of the above-mentioned result of Sathe et al., and generalize it to the case of vector systems.


This paper presents (i) an algorithm for the detection of unexpected stack voltage deviations in an Solid Oxide Fuel Cells (SOFC)-based power system with multiple stacks and (ii) its validation in a simulated online environment. The algorithm is based on recurrent neural networks (RNNs) and is validated by using operating data from the Wärtsilä WFC20 multi-stack SOFC system. The voltage deviation detection is based on statistical testing. Instead of a hardware implementation in the actual power plant, the algorithm is validated in a simulated online environment that provides data I/O communication based on the OPC (i.e. Object Linking and Embedding (OLE) for Process Control) protocol, which is also the technology utilized in the real hardware environment. The validation tests show that the RNN-based algorithm effectively detects unwanted stack voltage deviations and also that it is online-viable.


Vegetative stage is an essential element for plants that shoot harvested. At that stage, the growth regulator application can directly increase the production quantively accelerate the potential formation and growth of roots and shoots. Coconut water is one of a  natural sources of growth hormone that has a potency to increase the early growth of the tea plant. This experiment aimed to find out the response of tea plant growth on the lowlands after centering with coconut water application. This experiment was conducted in experimental garden of Faculty of Agriculture Unpad, Jatinangor, Sumedang at an altitude of 750 m above sea level and Inceptisol terrestrial soil. The experiment began in February 2016 until June 2016 using Split Plot Design, consisting of two factors and three replications. The main plot is a type of clone (K) which consists of two levels, namely: k1 = GMB 7, k2 = GMB 11. Sub plot is a coconut water concentration (A) consisting of five levels: a0 = coconut water application (control), a1 = coconut water concentration 25%, a2 = coconut water concentration 50%, a3 = coconut water 75% concentration, a4 = coconut water 100% concentration. The experimental results showed that coconut water had a significant effect on all treatments. The interaction of plant height variable at 14 WAC - 16 WAC (Week After Centering), canopy width at 12 WAC - 16 WAC and stem diameter at 14 WAC - 16 WAC and no significant effect on plant height at 2 WAC - 12 WAC, canopy width at 2 WAC - 10 WAC, and stem diameter at 2 WAC - 12 WAC, at 2 WAC - 12 WAC. In general, GMB 11 clone tea plant that applied 75% coconut water performed the best growth response on tea growth in the lowlands after centering.


: Currently research pays little attention on function coordination, structure order and dynamic feedback during evaluating the carrying capacity of resources and environment (CCRE). This paper based on the perspective of factor supply, establishes a CCRE ' s evaluation system which includes the development and utilization intensity, scale guarantee and potential improve-ment of resource factors, the pollution scale, pollution rate and pollution control capacity of environmental factors. We use resource supply and demand balance method as well as environmental capacity method to measure the carrying capacity index. Through carrying out the empirical analysis by Jiangsu Province, measuring and analyzing the degree of coordination development between resources and environment elements. We find that, (1) in terms of resources carrying capacity index, the cultivated land carrying capacity is 0.99, the rural and urban construction land is 1.22 and 1.96 respectively, the water resource is 1.24, the resource comprehensive carrying capacity is 1.25, and the population carrying capacity of resources ranges from 76.53 to 115.79 million people. (2) in terms of environmental carrying capacity index, from low to high is the soil environmental carrying index, atmospheric environmental carrying index and water environmental carrying index, the carrying index is 1.27, 2.68 and 5.20 respectively, and the environmental comprehensive carrying capacity is 2.95. (3) in terms of coordinated development, the average degree of coordination between resources and environmental factors is higher than 0.86, and the average degree of coordinated development is also higher than 7.3, however, there are also uncoordinated developments between individual elements in individual regions. We give suggestions from the aspects of resources, structure and technology based on the conclusion. Based on the dynamic concept of sustainable development, the idea and method of this research have a certain reference value, which conveying functional coordination, structure order, and dynamic feedback of land use planning objectives un-der the background of current supply-side reforms.