AIM: Recently,it is widely accepted that atherosclerosis(AS) is an auto-immune related disease and the oxidized-low density lipoprotein(ox-LDL) is the most important AS-related antigen.In order to prevent immune injuries in AS and find new strategies to prevent AS,the immune tolerance of T cells to ox-LDL in vitro was induced in this study.METHODS: Human monocytes were separated from peripheral blood to induce dendritic cells(DCs).DCs were treated with LPS(30 μg/L),ox-LDL(10 mg/L) and LDL(10 mg/L) for 48 h.Then DCs were mixed with allogenic T lymphocytes to carry out mixed lymphocytes reaction(MLR).CTLA4Ig in different concentrations was added in the MLR of ox-LDL group.MTT method was used to assay the proliferation of T cells and expressed in stimulation index(IS).The CD25 expression and apoptosis of T cells in MLR were tested by flow cytometry.The excretion of IL-2,IFN-γ and IL-4 was assayed by ELISpot method.RESULTS: SI in ox-LDL group was higher than that in LDL group significantly(P0.05) and CTLA4Ig inhibited the SI in ox-LDL group with dose-dependent effect(P0.05,P0.01).CTLA4Ig decreased the CD25 expression(P0.05,P0.01) and induced apoptosis of T cells in MLR(P0.05,P0.01).CTLA4Ig decreased the ELISpot counts of IL-2 and IFN-γ(P0.01),while increased that of IL-4(P0.05).CONCLUSION: CTLA4Ig induces T cells tolerance to ox-LDL in vitro.CTLA4Ig inhibits T cells activation,promotes T cells apoptosis and Th1/Th2 immune deviation,which is the important mechanism in it′s induction of tolerance.


Starting from influencing factors of durability of the reinforced concrete structure,this paper analyzes the effects of the carbonization and corrosion of steel bar have on the durability of reinforced concrete structure,and lastly proposes to increase in the thickness of protective layer to improve the durability of concrete structure.


International and Russian legal definitions of a conception the right to work are considered. The researcher had substantiated a role of a labour contract as one of most consequential forms of a realization of the right to work. He names chief components inseparabled from a worthy realization of the right to work by means of a labour contract.


Amplification of picosecond pulses from an actively modelocked semiconductor diode laser in an erbium-doped fibre amplifier pumped at 532 nm is demonstrated. Peak emission was centred on 1.536µm and a saturated amplifier gain of 13dB yielded less than 10ps pulses with a peak power of 0.58 W at 600 MHz. Optimisation of the mode-locked oscillator allowed amplified peak pulse powers greater than 3W to be generated.


Online gambling is the result of combining gambling with the internet age.Compared with traditional gambling,online gambling exerts greater harm to society with wider subjects,more complex objects and more diverse criminal forms.Online gambling legislation in China still has its inadequacy.It is recommended to refine the classification and the scope of the gambling subjects,increase the statutory responsibility of internet gambling behavior,strictly prohibit the flows of gambling money,and improve the international cooperation in anti-gambling.


Elevator accidents are common. To ensure the safety of elevators, improve the efficiency of elevator maintenance and rescue personnel for the first time, this paper designs an elevator status acquisition terminal based on NB-IoT. STM32 is the core, and the elevator status signal is collected by installing sensors in the elevator car. After preprocessing, the collected elevator status information data is uploaded to the monitoring platform for monitoring through the NB-IoT module. In order not to be affected by the power failure, the system uses an uninterrupted power supply to ensure the normal collection of data.


Macroscopic and nanoscopic current−voltage measurements reveal asymmetries in the DC electrical conductivity through Langmuir−Blodgett multilayers and even monolayers of γ-(n-hexadecyl)quinolinum tricyanoquinodimethanide, C16H33Q-3CNQ (5). These asymmetries are due to a transition of the ground-state zwitterion to an excited-state conformer which is probably neutral. Unimolecular electrical rectification by monolayers of 5 is unequivocally confirmed.


The brachioradialis forearm flap provides an alternative of intraoral reconstruction between a thin, pliable fasciocutaneous flap and a bulky musculocutaneous flap. From April, 1995 to April, 1996, ten cases of advanced oral squamous cell carcinoma were reconstructed by this compound flap with good results. According to the position of the muscular portion, the clinical applications can be classified into three types: type Ⅰ, for tamponade of dead spaces; type Ⅱ, providing neck protection; and type Ⅲ, in lip reconstruction. The vascular anatomy of brachioradialis muscle was also noted. In 4 of our 10 cases, the largest perforators arose from the brachial artery or the bifurcation, and could not be included in the radial forearm flap. The proximal segment of muscle must be trimmed due to poor perfusion. The unreliability implies the brachioradialis may be a type Ⅳ rather than type Ⅴ muscle according to Mathes and Nahai's classification.


Education is of interest to many economists because of its perceived importance for a wide variety of economic issues. But like others in society, economists also have a personal interest in education -having been students and perhaps taught themselves, having had children who are students, and often having formed strong opinions about educational policy through their own experiences. This combined professional and personal interest in education undoubtedly has heightened the interest in school research and led to stronger reactions to the policy implications of that research.


A system dynamics model of water resources utilization in urban ecosystem was established.The relationships among water resources utilization,urban economic development,and pollutant emissions,etc in urban ecosystem-were analyzed.Taking Fushun for instance,four water resources utilization patterns in urban ecosystem were designed,and then the trends of water resources utilization in urban ecosystem were forecasted and analyzed during 2011-2020.The results show that the water resources system in urban ecosystem consisted of four subsystems,namely,water resources subsystem,population subsystem,economy subsystems and environment subsystem.The comprehensive development pattern can improve the utilization of water resources in Fushun city among the four,and in that case,the water resources factor,total population,the GDP of secondary industry,COD discharging will reach 1.042 2,2.16 million,123.46 billion Yuan,and 31 308 t,respectively.


Systemic therapy is the primary treatment for advanced thymic malignancies. However, there is an urgent need to improve clinical outcome. Personalized treatment based on predictive biomarkers is a potential approach to address this requirement. In this study, we aimed to show the correlation between drug sensitivity tests on CTCs‐derived organoids and clinical response in patients with thymic malignancies. This approach carries the potential to create personalized cancer avatars and improve treatment outcome for patients.


CPT violation has the potential to explain all three existing neutrino anomalies without enlarging the neutrino sector. CPT violation in the Dirac mass terms of the three neutrino flavors preserves on-shell Lorentz invariance, but generates independent masses for neutrinos and antineutrinos. This specific signature is strongly motivated by braneworld scenarios with extra dimensions, where neutrinos are the natural messengers for Standard Model physics of CPT violation in the bulk. A simple model of maximal CPT violation is sufficient to explain the existing neutrino data quite neatly, while making dramatic predictions for the KamLAND and MiniBooNE experiments. We obtain a promising and economical new mechanism for electroweak baryogenesis.


Summary and Conclusions The inhibitory effects of aspirin on platelet function persist during long-term administration. This drug would therefore appear to hold promise as an antithrombotic agent.


PURPOSE: A method and security system thereof are provided to improve the security and safety of data by protecting transmission data based on asymmetric keys. CONSTITUTION: A first security module provides a first public key to a second security module(503). The second security module provides a second public key by encoding the second public key based on the first public key(505). The second security module provides second verification data related to the second security module by encoding the second verification data based on the first public key to the first security module. The first security module acquire the second public key by decoding the encoded second public key based on a first private key(507). The first security module provides the first verification data related to the first security module by encoding the first verification data based on the second public key to the second security module(509).


Purpose: Resuscitation rooms in emergency department are places for time-critical tasks. This study aimed 1) to develop a resuscitation protocol for dyspneic patients and 2) to evaluate the effect of the resuscitation protocol for dyspneic patients in improving clinical performances. Methods: A panel of experts including emergency physicians and nurses developed a resuscitation protocol for dyspneic patients which included a list of critical interventions and time-limits. The resuscitation protocol was implemented in a emergency medical center for two months. Clinical performances of health care providers were compared by analyzing video-recorded clinical performances. Results: The resuscitation protocol consisted of four steps: Initial treatments within 5 minutes, main treatments within 15 minutes, diagnostic tests within 30 minutes, and disposition within 60 minutes. A total of 43dyspneic patients (23 patients experimental group, 20 patients control group) were included for the analysis of the clinical performance change. Clinical performance rates were improved significantly from control group (66.71%) to experimental group (82.41%) after implementing the resuscitation protocol (Z=-3.09, p=.004). Conclusion: The resuscitation protocol developed for dyspneic patients improved clinical performance rates of health care providers. Further development of clinical protocols for other emergent cases at resuscitation rooms are strongly recommended.


The purpose of this study is to investigate dimensional accuracy (Δd), surface roughness (Ra) and micro hardness (HV) of partial dentures (PD) prepared with synergic combination of fused deposition modelling (FDM) assisted chemical vapour smoothing (CVS) patterns and conventional dental casting (DC) from multi-factor optimization view point.,The master pattern for PD was prepared with acrylonitrile butadiene styrene (ABS) thermoplastic on FDM set-up (one of the low cost additive manufacturing process) followed by CVS process. The final PD as functional prototypes was casted with nickel–chromium-based (Ni-Cr) alloy by varying Ni% (Z). The other input parameters were powder to water ratio P/W (X) and pH value (Y) of water used.,The results of this study suggest that for controlling the Δd and Ra of the PD, most important factor is X, followed by Z. For hardness of PD, the most important factor is Z. But from overall optimization viewpoint, the best settings are X-100/12, Y-10 and Z-61% (in Ni-Cr alloy). Further, based upon X-bar chart (for HV), the FDM-assisted DC process used for preparation of PD is statistically controlled.,This study highlights that PD prepared with X-100/12, Y-10 and Z-61% gives overall better results from multi-factor optimization view point. Finally, X-bar chart has been plotted to understand the statistical nature of the synergic combination of FDM, CVS and DC.


The study provides the information on exploring the concept of Physical Education is a Philosophy for healthy mankind. In order to carry out the study the project team collect data from related literature like books, magazines, journals and online resources. Results of our study revealed that the use of physical activities for the development of total health is not a new tradition. It has been there since antiquity, and has been transferred from one generation to other. In present world human being, no doubt has sort out different treatment to throw out serious development challenges. But due to the advancement there is an increase in the physical inactivity which also eventually leads to the inclination of mental challenges (psychological ailments) and medical elements like chronic non communicable diseases (diabetes, blood pressure, etc). Due to this physical inactivity serious threats have been make to health of the individuals especially in physical, mental, social and emotional aspects of the well being. The study throws light on the different dimensions of Physical Education namely Physical, Mental, Social and Emotional by elucidating their contribution in preparing the healthy citizens by emphasizing their vital role for the preparation of an individual for their lives and as a whole for mankind.


The role of microenvironmental interactions in lymphoma growth is increasingly being recognized but still poorly understood. In this issue of Blood , Rehm and colleagues used a mouse model of aggressive B-cell lymphoma to show that the chemokine receptor CCR7 plays a pivotal role in homing of tumor


The standpoint of academic circles about Zhang Xue-liang and His nonresistance policy in " 9.18 " is quite conflicting. There are four views: First, some believe that Zhang Xue-liang is just to faithfully carry out Jiang Jie-shi's policy. Second, others think that Jiang Jie-shi was a contriver of nonresistance policy, and Zhang just had carried out it. Third, the others think, though the nonresistance policy which Zhang Xue-liang had carried out included partial resistance, he should be blamed for the lost of Northeast. Last, people think that the nonresistance policy which Zhang Xue-liang had carried out in "9.18" is actually contained some of "resistance". About the question of who should undertake the responsibility in "The September 18th incident" ,the writer of this paper thinks that the Nanjing government who made the nonresistance policy should take on main responsibility, Zhang Xue-liang carried out the nonresistance policy, also should be responsible for it.


In this study, multilayer piezo stack transformers for switching mode power supply (SMPS) application were manufactured using 0.01Pb(Ni1/3Nb2/3)O3 - 0.08Pb(Mn1/3Nb2/3)O3 0.91Pb(Zr0.505Ti0.495)O3 (PNN-PMN-PZT) ceramics. The voltage ratio of a multilayer piezo stack transformer showed a maximum at the resonance frequency of the input and then increased with increasing load resistance. The eciency of the multilayer piezo stack transformer showed its highest value at around the matching load. The output power increased with increasing input voltage. The temperature of the multilayer piezo stack transformer increased with increasing output power and load resistance. The manufactured multilayer piezo stack transformer could be used up to 5 W at a resonance frequency of 70.25 kHz for SMPS application because the temperature rise from room temperature is believed to about 20 C and because the transformer is electrically stable. The newly-developed ring-dot-type step-down multilayer piezo stack transformer shows possible applications as SMPS for electronic power sources with excellent input-to-output properties.


Moringa Oleifera is one of the most useful tropical trees. Its leaves are extremely valuable source of nutrition for people of all ages. Nutritional analysis indicates that Moringa leaves contain affluence of essential, disease preventing nutrients. They even contain all of the essential amino acids, which is unusual for a plant source. The young leaves are edible and are commonly cooked and eaten like spinach or used to make soups and salads. They are an exceptionally good source of provitamin A, vitamins B, and C, minerals (in particularly iron), and the sulphur-containing amino acids methionine and cystine. The composition of the amino acids in the leaf protein is well balanced since the dried leaves are concentrated; they contain higher amounts of many of these nutrients. In this paper processing of fresh Moringa leaves into dry form for consumption purpose has been described.


In order to solve the problem in the image process researches,it is very important to find an efficient,biologic recognition related,and high-level semantic image classification method.By adopting the theories of biologic visual recognition and knowledge engineering combined with biologic characteristic(information,) and using minimum spanning tree as an image information construction tree,this paper pre-(sents) a sparse coding-based image semantic classifier (SCISC) model.The experimental result shows that this model has high accuracy in image classification.


See related article, pages 255–262

Endothelial cell protein C receptor (EPCR) is a type 1 transmembrane glycoprotein with homology to the major histocompatibility complex (MHC)-class 1/CD1 family of molecules.1 EPCR was isolated and cloned as an endothelial cell-specific, high selectivity and high affinity binding protein for protein C (PC) and activated PC (APC).1 EPCR binds PC on the endothelial surface and presents it to the thrombin:thrombomodulin (TM) complex for activation (Figure 1). Thrombin bound to TM proteolytically activates PC and generates APC which exerts independent anticoagulant and cellular activities.2 The APC anticoagulant pathway is mediated by proteolytic inactivation of blood coagulation Factors Va and VIIIa with the contribution of several cofactors, including protein S, high density lipoproteins, phosphatidylserine, cardiolipin, and glucosylceramide to name a few. The APC cellular pathway on endothelium requires EPCR and the protease activated receptor-1 (PAR-1)3 which mediates APC's cytoprotective effects, including alterations in gene expression profiles, antiapoptotic activity, antiinflammatory activity and protection of endothelial barriers4–10 (Figure 1). EPCR also regulates endogenous physiologic activation of PC by thrombin which is linked to PAR-1-dependent APC protective autocrine signaling in endothelium.11

Figure 1. EPCR binds protein C (PC) on endothelium and presents it to TM (thrombomodulin)-thrombin complex for activation by thrombin. Activated PC (APC) dissociates from EPCR and TM-thrombin complexes and inactivates coagulation factors Va and VIIIa into inactive forms Vi and VIIIi promoting anticoagulation. APC bound to EPCR activates the protease activated receptor-1 (PAR-1) which binds the Gq and Gi proteins to activate phosophlipase(s) (PLC) in SMCs and endothelium resulting in IP3 (inositol triphosphate)-mediated release of intracellular [Ca2+]i, activation of mitogen-activated …


The Aircraft Noise Reduction (ANR) sub-project is focused on the generation, development, and testing of component noise reduction technologies progressing toward the NASA far term noise goals while providing associated near and mid-term benefits. The ANR sub-project has efforts in airframe noise reduction, propulsion (including fan and core) noise reduction, acoustic liner technology, and propulsion airframe aeroacoustics for candidate conventional and unconventional aircraft configurations. The current suite of propulsion specific noise research areas is reviewed along with emerging facility and measurement capabilities. In the longer term, the changes in engine and aircraft configuration will influence the suite of technologies necessary to reduce noise in next generation systems.


This publication may be cited as: Berry, T-A. & Wairepo, D. (2015). Asbestos remediation in the cook islands: A long-term solution for making schools safer. In M. Panko & L. Kestle (Eds.). Building Today Saving Tomorrow: Sustainability In Construction And Deconstruction Conference Proceedings. (pp. 6-17). Auckland, New Zealand: Unitec Institute of Technology. Retrieved from: www.unitec.ac.nz/epress/


After the major fruit set period was completed, aqueous sprays of 1000 ppm dikegulac, 66 ppm ancymidol, 1000 ppm maleic hydrazide (MH), and 1 kg·ha−1 RSW 0411 were applied to processing tomato (Lycopersicon esculentum Mill) plants. Dikegulac, RSW 0411, and ancymidol visually reduced vegetative growth, whereas MH had no apparent influence. None of the compounds reduced the number of flower clusters or flowers per cluster on the late-season growth, but dikegulac and RSW 0411 did reduce the percentage of fruit set in the terminal regions. The partial reductions in late vegetative and/or reproductive growth from the chemical treatments did not enhance uniformity of fruit maturity. Only the dikegulac treatment decreased the yields and percentage of green fruit from the harvest. Chemical names used: 2,3:4,6-bis-O-(1-methylethylidene-d-l-xylo-2-hexulofuranosonic acid (dikegulac); α-cyclopropyl-α-(4-methoxyphenyl)-5-pyrimidinemethanol (ancymidol); 1,2-dihydro-3,6-pyridazinedione [maleic hydrazide (MH)]; and β-(cyclohexylmethylene-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol (RSW 0411).


Supersonic im~~inging jets produce a highly unsteady flowfield leading to a noisy environment with high dynamic pressure loads on nearby surfaces. In prior work, it was demonstrated that microjet injecti on along the circumference of the main jet nozzle directly into the shear layer of the main jet disrupts the feedback loop inherent in high-speed impinging jet flows, thereby significantly reducing the adverse effects produced. The microjet action was due t o steady blowing whose flow rate was either uniform along the circumference or varied using the eigenmode of the flow. While these methods yielded some successes, ulliform reduction of all operating conditions was not t o obtained. In this paper, pulsing microjet injection is chosen as a new control scheme to retain a uniform suppression of impinging jet noise. Through pulsing injection, a fairly good amount of noise reduction w ls achieved using 42% of the mass flow rate that led to the same level of noise reduction using steady microjet injection. As the duty cycle was increased, it was observed that the pulsed injection completely destroyed the distinct impinging tone for almost all heights.


This article deals with the major techniques in transplanting and maintaining big trees at various stages,including digging,packaging,transporting,downloading,and transplanting so as to improve their survival rate and later maintenance.


Many modern software models and notations are graph based. UML 2 activities are important notations for modeling different types of behavior and system properties. In the UML 2 specification it is suggested that some forms of activity types are based on Petri net formalisms. Ideally the mapping of UML activities into Petri nets should be bi-directional. The bi-directional mapping needs to be simplified and operational. Model-to-Model mapping in theory offers the advantage of fully operational bi-directional mapping between different models or formalisms that share some common properties. However in reality this is not easily achievable because not all the transformations are similar. Previous work was presented where it was shown how Triple Graph Grammars are useful to achieve this mapping. UML 2 activities have some common properties with Petri nets. There are exceptions which require some special attention. In this paper a simple condensed rule based solution for complete bi-directional mapping or transforming UML 2 activities into Petri nets is presented. The solution should be operational, and can be represented using different notations. A practical example is used to illustrate the bi-directional transformation possibility and conclusions are explained. Keywords— UML 2, Activity diagrams, Petri nets, Bi-directional transformation, Triple graph grammars


Objective:To investigate the effect of microencapsulation of protein drugs-loaded dextran nanoparticles into poly(D,L-lactic-co -glycolic acid)(PLGA) microspheres on integrity of protein drugs,and improvement of release profiles of protein drugs in vitro.Methods:Bovine serum albumin(BSA)-loaded dextran nanoparticles were prepared by the method of freezing-induced phase separation,then the protein-loaded dextran nanoparticles were microencapsulated into PLGA microspheres by solid-in-oil-in-water(S/O/W) multiple emulsion technique.The samples were characterized by size exclusion HPLC(SEC-HPLC) and Fourier-transform infrared spectroscopy(FTIR).In vitro release profiles of the samples were also detected.Results:The integrity of BSA was protected perfectly by this method and the release behavior of the microspheres were improved.Conclusions:This method is a effective technique for protein-controlled release.


Amino acid analysis is a strong tool for the analysis of protein primary structure and plays an important role in the qualitycontrolofrecombinantprotein biologics. Its main application includes the analysis of amino acid content and component, precise quantitative determination of protein and calculation of extinction coefficient,which provides a basis for structure identification and function study of recombinant proteins. This paper reviews the application of amino acid analysis in quality control of recombinant protein biologics.


In cities with serious air pollution, travel time and health damage significantly affect route choice by travelers (e.g., motorcycle and scooter drivers). Consequently, the classical Braess paradox is no longer realistic because it only considers the traveler's value of time (VOT). In the current study, we describe a new transportation network paradox that considers both the VOT and the traveler's perception of pollution damage. To examine the conditions that create the new paradox, we developed a novel method to compute a total comprehensive cost that combines the VOT with health damage. We analyzed the conditions for the new paradox and the system's performance using a user equilibrium model and system optimization. Furthermore, an improved model is used to analyze how different transport modes influence the Braess paradox. We found that whether the new paradox occurs and the potential improvement of the system's performance depend on whether the total travel demand falls within critical ranges. The bounds of these ranges depend on the values of the parameters in the function that describes the health damage and the link travel time function. In addition, high health damage significantly affects route choices and traffic flow distribution. This paper presents a new perspective for decision-making by transportation planners and for route choices in cities with serious air pollution.


In this paper we study experimentally the dynamics of a non linear system: a spring pendulum coupled to an oscillator. The system was tested using a hybrid technique called Real Time Dynamic Substructuring (RTDS)[1, 2]. RTDS is a testing technique that involves splitting the system under study into two subsystems: one will be physically tested (physical substructure) and the other will be simulated in the computer (numerical model). These substructures interact in real time through a set of transfer systems. RTDS is a very powerful experimental methodology that not only allows full scale and real time testing but also real‐time bifurcation tracking in complex engineering systems [3, 4]. In our hybrid experiment the spring pendulum is taken to be the physical substructure while oscillator is the simulated numerical model. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


Heating furnace has played a very important role in the iron and steel enterprises. Due to the complex environmental interference, it is difficult to measure parameters, and this has influenced the accuracy and stability of the control system deeply, at the same time, there may be some potential security risks. In this paper, a hybrid intelligent pre-processing system of process parameters is proposed for furnace control. The system consists of several steps: the prediction of some parameters by self-adaption or fuzzy neural network, the parameter filtering, the parameter estimation in the way of production rule, the abnormal parameters modification with case-based reasoning, eta. This system could make the furnace control become accuracy and stability, and eliminate potential security risks. This proposed intelligent pre-processing system has been successfully applied by a steel enterprise in Gansu Province, China, and achieved good results. The system has a good prospect of application and extension in other similar industrial processes.


Network calculus is a new quantitative analysis tool for obtaining deterministic bounds on network performance. This paper summarizes some results of network calculus and presents a framework of generalized processor sharing based on leaky bucket regulator. It derives the bounds on queue size, delay and effective bandwidth by network calculus. Examples and results are presented to demonstrate the practicability and validity of the approach, which is practical and well suited for analyzing performance bounds in guaranteed service networks.


In the present paper it was carried out an investigation of influence of meliorative application of fertilizers on grain yield, mass of hectoliter and 1000 kernel weight in some varieties of spring wheat, spring barley and spring oat, grown on acid soil. Small grains demonstrated different reaction on increased acidity of soil. Oat varieties were significantly more tolerant and achieved acceptable grain yield compared to spring barley and wheat varieties, that on such soil could be grown only with previous liming. Meliorative application of fertilizers increased the grain yield of wheat by 2.7 times, in barley by near 4 times and in oat by about 2.5 times in average for all varieties and treatments. The best results were achieved by joint application of NPK, lime and manure.


Objective: To investigate the causative factors and complications attributable to obesity in children living in Jeddah, Saudi Arabia. Methods: This is a retrospective study encompassing a sample size of 151 children and adolescents between the ages of 4 and 20 years. Data was collected through reviewing medical records, medical files on the hospital electronic system and clinical interviews conducted with legal guardians. Date of study was from January to June 2018, and was carried in Jeddah, western region, Saudi Arabia. Results: Data was entered, coded, cleaned and analyzed using statistical package for social science (IBM SPSS), version 22. The analysis was done by assessing the significance of various risk factors and sequelae in their contribution to paediatric obesity by one-way ANOVA for nominal variables of more than two categories and Independent sample t-test for the nominal variables with two categories. The sample was 47% of the male gender whereas females made for the remaining 53%. The causation of obesity was distributed among the following factors: an unhealthy diet, a sedentary lifestyle, medications such as glucocorticoids, and Complications attributed to obesity included gastro-oesophageal reflux, hypertension, precocious puberty, sleep apnoea, psychological disturbances and fatty liver diseases. Conclusion: Environmental factors were found to be the most predominant cause, where the majority of children were found to be leading a sedentary lifestyle, following an unhealthy diet, and skipping meals. The most recurring complications involved psychosocial and behavioural abnormalities, and among the medical consequences, gastro-oesophageal reflux and obstructive sleep apnoea were the most prevalent. (www.actabiomedica.it)


The purpose of the study is to describe how Swedish municipalities recruit the current labour market in response to immigration movement. Data from Swedish Immigration Agency (Migrationsverket, 2017) from 2013 to October 2017 show the highest number of asylum applicant was in 2015 with 162.877 applicants. However, in October 2017, Swedish Public Employment Service (Arbetsförmedlingen) revealed the new data from August 2017 which said that Swedish unemployment rate decreases from 7.6% to 7.4% compared to the same month last year. The rise of labour force occurs in many countries. Thus, the Swedish strategies in handling the problem may contribute as a references in the recruitment process and employee distribution strategy. The study used qualitative method based on in-depth interview were conducted with thirteen (13) Human Resource (HR) managers and specialist from ten (10) municipalities in Sweden as the data collection method. The perspective of translation concept is used as the analytical basis. The research found that the labour market in Sweden experience lack of employee, and high disparity in the unemployment rate between native-born and foreign-background. In order to cope with this situation, municipalities implement different strategies and programs such as "move a friend" program, re-employed retired staff, collaboration with other organisation (Arbetsförmedlingen and Mittliv) for staff level and talent pool management in the managerial level. The research also revealed that in order to open more opportunity for the foreignbackground applicants, municipalities apply competence-based recruitment system that focuses on the candidate's personal competencies rather than education qualification or background. Keyword— immigration, diversity, lack of employees, public


The invention relates to a device for processing containers, in particular for printing on containers. The device comprises at least one rotor (1), which has a plurality of processing positions (3) on the rotor circumference thereof and can be driven such as to revolve around a vertical rotor axis or machine axis in a direction of rotation of the rotor, and comprises at least one extractor device (6) for extracting foreign materials or contaminants that accumulate during processing, wherein said extractor device extends in the direction of rotation of the rotor at least over a part of the rotor circumference and laterally surrounds the rotor (1).


Abstract In this article, we propose new parallel algorithms for the construction and 2:1 balance refinement of large linear octrees on distributed memory machines. Such octrees are used in many problems in computational science and engineering, e.g., object representation, image analysis, unstructured meshing, finite elements, adaptive mesh refinement, and N-body simulations. Fixed-size scalability and isogranular analysis of the algorithms using an MPI-based parallel implementation was performed on a variety of input data and demonstrated good scalability for different processor counts (1 to 1024 processors) on the Pittsburgh Supercomputing Center's TCS-1 AlphaServer. The results are consistent for different data distributions. Octrees with over a billion octants were constructed and balanced in less than a minute on 1024 processors. Like other existing algorithms for constructing and balancing octrees, our algorithms have ϑ (N log N) work and ϑ (N) storage complexity. Under reasonable assumptions on the distribution of octants and the work per octant, the parallel time complexity is ϑ (N/n p log np log(N/n p ) + n p log n p ), where N is the size of the final linear octree and n p is the number of processors. Abstract. In this article, we propose new parallel algorithms for the construction and 2:1 balance refinement of large linear octrees on distributed memory machines. Such octrees are used in many problems in computational science and engineering, e.g., object representation, image analysis, unstructured meshing, finite elements, adaptive mesh refinement, and N-body simulations. Fixed-size scalability and isogranular analysis of the algorithms using an MPI-based parallel implementation was performed on a variety of input data and demonstrated good scalability for different processor counts (1 to 1024 processors) on the Pittsburgh Supercomputing Center's TCS-1 AlphaServer. The results are consistent for different data distributions. Octrees with over a billion octants were constructed and balanced in less than a minute on 1024 processors. Like other existing algorithms for constructing and balancing octrees, our algorithms have O ( N log N ) work and O ( N ) storage complexity. Under reasonable assumptions on the distribution of octants and the work per octant, the parallel time complexity is O ( Nn p log( Nn p ) + n p log n p ), where N is the size of the final linear octree and n p is the number of processors.


Herein, an improved thermal‐mechanical coupled analysis is used to increase the calculation efficiency of the detailed laser melting deposition (LMD) process. By optimizing the loading process of the laser heat source and lumping several deposited layers into an equivalent numerical layer, the efficiency is significantly improved. The calculation time is saved by 85% when lumping six layers. Compared with the experimental data, the minimum deviation of predicted maximum distortion reaches 3.2% when lumping four layers. A multiscale method is proposed to predict the distortion result of the large‐sized part efficiently. In this method, the optimal heights of equivalent numerical layers are explored. The comparisons with the experimental result show that the optimal heights of equivalent numerical layers are 1 and 1.5 mm in view of accuracy and efficiency. Based on the multiscale method, the residual distortion of the substrate after depositing a large‐sized eight‐layer line deposition structure is accurately predicted. The deviations of the maximum distortion predicted by the improved thermal‐mechanical coupled simulation and the multiscale method are 3.26% and 6.12%, respectively. Moreover, the calculation time of the latter is 98.8% less than that of the former.


Introduction: The oxygenation index (OI) is a new indicator whose predictive value has not been studied in adults. Objectives: To determine the usefulness of the oxygenation index as a marker of mortality in adult patients with acute respiratory distress syndrome (ARDS). Methods: An analytical and longitudinal study in patients who met the diagnostic criteria for ARDS with settling time less than 36 hours is presented. Oxygenation calculations were performed within 24 hours, with consecutive samples at 48 and 72 hours. Results: The average age in the group of survivors was 35,6 years old vs. 53,5 years in non-survivors. The average rate of oxygenation in the first 24 hours in the group of survivors was 11, whereas in non-survivors of 23,7. 48 hours measure had an average of 7,4 in survivors and 17,1 in non-survivors; also, in 72 hours measure an average of 9.5 in the group of survivors was obtained vs. 18,8 in non-survivors. Conclusions: The oxygenation index is useful as a marker of mortality in adults in the early acute phase of ARDS when compared with other parameters of oxygenation.


With the disclosure of some criminal false judgments, flexible verdicts have gradually captured public attentions recently. The basic characteristics of this kind of verdicts are "presumed guilty until proven innocent" and "imposing a lenient sentence if be presumed guilty", which also mean that courts will make a guilty verdict and impose a lenient sentence although the standards of guilty verdicts are not yet satisfied. In terms of the judicial system and judicial procedure, the reasons for this kind of verdicts are complex. Under the influence of them, Chinese courts can't become the vindicator of justice, but only to survive by compromise due to the judicial idea of realism. However, after the disclosure of many "cases in which people were unjustly, falsely or wrongly charged", courts often become the victims of system. So long as this kind of judicial manner still exists, judicial credibility of courts will never be established and the criminal judicial system won't have any substantial change definitely.


The process of functional correlation in a research project ensures the balance and interdependence among the management process variables (purpose – objectives – activities associated to objectives - resources), allowing the achievement of efficient scientific research in the domain of sports organization management.


Library guide to assist in finding resources on a specific research topic. Guide includes how to create an annotated bibliography, and links to books, articles, films on aging, and more. Home page.


Abstract : A combination of findings on post earthquake public behavior suggests that persons who are outside a certain perimeter following a disaster are given less assistance by disaster agencies and are not defined by others as 'victims' while often experiencing what they themselves consider to be severe emotional damage.


This paper considers the views of Origen's position on apocatastasis in the ancient philosophy and Christian theology. Briefly maps the features of the doctrine of posthumous incarnation of Origen in the West and East. Analyzed. It concludes that Origen brings together Eastern and Western tradition in the study of postmortem human incarnation, while postulating the unity and posthumous embodied in the Universal Resurrection (ie, pure Christian doctrine) and the possibility of posthumous incarnations, and reincarnation is not Vedic, and reincarnation of a diverse world by the entire set of living in his shower.


The increasing energy demand has enhanced the use of renewable energy as the source of fossil fuel cannot meet up this demand. The photovoltaic cell converts sunlight to electricity without any pollutant emission. A complete analysis on Photo Voltaic system is required to get the maximum output. But because of some external and internal factors, the generation of maximum output power is disrupted. Shading, temperature, irradiance as external factors and series and parallel resistance as internal factors change the maximum power point of a Photo Voltaic system. In this research, the generalized model for Photo Voltaic system was implemented in MATLAB interface. According to the change of the values of irradiance, shading, temperature, series and parallel resistance. The I-V and P-V characteristics are analyzed for the best case. On the basis of the analysis, effective Photo Voltaic system is built which gives approximately 5000W output by using the best values for the above mentioned factors. The proposed system is built to serve the purpose of an industry.


Abstract In Monolingualism of the Other (Stanford, CA: Stanford U P, 1998), Jacques Derrida declares: "I have only one language—it is not mine" (Je n'ai qu'une langue, ce n'est pas la mienne). This statement is a near impossible postulation, for how can one speak a language that one does not possess? This essay analyses the antinomy of "I have only one language—it is not mine," and Derrida's monolingualism in conjunction with Abdelkebir Khatibi's bilingualism; Khatibi is also revealed as the titular Other. For, as this essay will show, Derrida's postulation is heavily dependent on Khatibi's Du Bilinguism, as well as on some of his earlier writings.


SYNOPSIS: Ground improvement techniques were used to meet the design requirements for a beach resort complex at Half Moon Bay on the Arabian Gulf. Extensive site exploration revealed upper layers consisting of loose to medium fine sand, having variable silt content. The original specification called for filling and ground improvement using Dynamic Compaction to achieve 100kN/m2 surface bearing capacity and 50% relative density at a depth of 10m. Com (DC} subsequent field testing, using full scale loading tests as well as CPT and tests, proved that it was possible to these requirements over most areas using dynamic compaction, however it was not suitable in a other areas where gro.und response to was poor. Those areas contained silty layers and showed signs of rapid pore pressure build up under dynamic compaction, while dissipation was slow and penetration resistance remained poor. There fore, it was decided to use pre-loading in those areas. Further testing and instrumentation showed that pre-loading was acbieving the required ground improvement.


In the current fierce international environment, Own brand has embodied a country's economic strength. It is hard to achieve leapfrog development for the own brand relying on traditional maintaining innovation. The article expects from the effective combination of technology and market on disruptive innovation to explore the new leap-forward developing path. Further analyzing from the theoretical and actual case; draw the conclusion that the disruptive innovation integrating with disruptive technology and the Blue Ocean market strategies is the effective path selection for the development of independent brands by leaps and bounds.


The prevalence of occupational health and safety (OHS) risks among mining firms points to inadequate corporate governance (CG) mechanisms (Baxter, 2016). The purpose of this study is to bridge the existing research gap by examining the impact of women on corporate boards and managerial ownership (MO) on occupational health safety risk management performance incorporating firm size moderating variables panel data from the Johannesburg Securities Exchange (JSE) of thirty (30) purposively sampled mining firms for the period 2002–2018. To the best of our knowledge, the study is one of the first pragmatic investigations of the impact of women on corporate boards, and managerial ownership on OHS risk management performance in the South African mining sector. A multivariate regression analysis based on quantitative secondary panel data confirmed a positive impact of managerial ownership, and board gender diversity on the OHS risk management performance of mining firms in South Africa. The study has practical implications for the existing body of knowledge, academics, regulators as well as mining firms' corporate governance bodies in South Africa, which recommend that current regulatory bodies need to implement effective and sound strategies that may considerably improve the mitigation of OHS risks to attain the "zero harm" milestone by December 2024.


Background Given the data on efficacy and safety of biologic treatment in rheumatoid arthritis (RA), more and more patients older than 65 years are starting these drugs. Objectives This study aims to evaluate safety and efficacy of biologics in elderly patients. Methods: four-hundred and thirteen patients with RA were enrolled and divided in two group, i.e. older or younger than 65 years old. Data on disease characteristics, treatment and adverse reactions were collected. In addition, comorbidities were evaluated by the Rheumatic Disease Comorbidity index (RDCI). Results Seventy-seven patients were male and 87 were older than 65 years. The elderly patients had a higher RDCI as compared to those younger than 65 years (1.0 ± 3.0 vs. 0.0 ± 10 respectively, p<0.001). Mean DAS28 at the beginning of biologic treatment was 4.46 ± 1.16. Most of patients started etanercept (41.4%) or adalimumab (26.9%) and 37.1% were on monotherapy. None of these variables were statistically different between age groups. The figure shows the differences in retention rate of first biologic at 60 months in the two groups that was found to be significantly higher in older than younger patients (43.3 vs. 48.5, p=0.023). This result was confirmed also after correcting for comorbidities as defined by RDCI (p=0.014). On the contrary, no differences were found in retention rate on any biologic (i.e. not only first line) between age groups (p=0.509). The main reason for biologic treatment discontinuation was inefficacy in both groups (74.7% in <65 years old and 58.6% in ≥65years old, p=0.161). The most common side effects in elderly patients were hematological complications (30.4%) while in younger patients muco-cutaneous (32.4%) adverse reactions. Infections were a reason for discontinuation in 17.4% in old patients and 20.6% in younger ones (p=1.000). Conclusion RA patients aged over 65 years have been found to have even a better retention rate at first biologic than youngers one, probably because of less strict targets in disease control and a more frequent follow up. In addition, safety has been found to be as good as in younger patients. Comorbidities do not seem to affect retention rate.Figure 1 Disclosure of Interests Cristian Caimmi: None declared, Federica Martinis: None declared, Ilaria Montanari: None declared, Alice Dellaidotti: None declared, Elena Fracassi Speakers bureau: Novartis, Ombretta Viapiana Speakers bureau: Novartis, Abbvie, Eli-Lilly, Sanofi Genzyme, Domenico Biasi: None declared, Maurizio Rossini: None declared, Antonio Carletto Speakers bureau: Roche, Novartis, MSD, Abbvie, Bristol, Jannsen, Celgene, Pfizer


The commenter establishes the stability in the sense of Lyapunov of the adaptive motion controller for robot manipulators reported by J. Slotine and W. Li (ibid., vol.33, p.995-1003, Nov. 1988). >


For a long time it has been known that the solar–system abundances of elements heavier than iron have been produced by neutron–capture reactions (Burbidge et al., 1957). Neutron–induced nucleosynthesis is also of relevance for abundances of isotopes lighter than iron (especially for neutron–rich isotopes), even though the bulk of these elements has been synthesized by charged–particle induced reactions. There are three main sites for nucleosynthesis: (i) primordial nucleosynthesis forming the light elements H, He and Li in the Big Bang, (ii) interstellar nucleosynthesis creating the elements Li, Be and B and finally (iii) stellar nucleosynthesis being responsible for the creation of all the elements from C to U. In these astrophysical scenarios neutron– induced reactions play a role in primordial nucleosynthesis in the early universe, in the s–process occurring in Red Giants, and in the α–rich freeze–out (α–process) and r–process thought to take place in supernovae of type II. In the early universe the neutrons are formed through the hadronization of the quark–gluon plasma. However, these neutrons decay soon due to their mean lifetime of about 15 minutes. In Red Giants neutrons are formed in helium burning through the reactions 22Ne(α,n)25Mg and 13C(α,n)16O. The above astrophysical sites and their relevance for neutron–induced nucleosynthesis will be discussed in Sect. 2. The experimental methods and measurements at thermal (kBT = 25.3meV) and thermonuclear energies (kBT ≈ 1 keV–1MeV) are presented in Sect. 3. In that section, we focus on neutron radiative capture, even though (n,p) and (n,α) reactions also play an important role in reaction networks up to A ≈ 40. For the experimental detection of the reaction events mainly two sig-


Portable digital cameras are being used widely by students and professionals in different fields as a practical way to digitize documents. Tools such as PhotoDoc enable the batch processing of such documents, performing automatic border removal and perspective correction. A PhotoDoc processed document and a scanned one look very similar to the human eye if both are in true color. However, if one tries to automatically binarize a batch of documents digitized from portable cameras compared to scanners, they have different features. The knowledge of their source is fundamental for successful processing. This paper presents a classification strategy to distinguish between scanned and photographed documents. Over 16,000 documents were tested with a correct classification rate of over 99.96%.


This paper explores the effects of transport costs, tariffs, and foreign wage rates on the domestic economy in the presence of reverse imports, with special emphasis on inter-firm cost asymmetry in an international oligopoly model. To serve the domestic market, a foreign firm produces in the foreign country, while two domestic firms produce either at home or abroad. Surprisingly, an increase in the foreign wage rate may increase the profits of a firm producing in the foreign country. Even if all firms produce in the foreign country, an increase in the foreign wage rate may improve domestic welfare.


In this article, we attempt to reconcile the linguistic hypothesis that speech involves an underlying sequencing of abstract, discrete, context-independent units, with the empirical observation of continuous, context-dependent interleaving of articulatory movements. To this end, we first review a previously proposed task-dynamic model for the coordination and control of the speech articulators. We then describe an extension of this model in which invariant speech units (gestural primitives) are identified with context-independent sets of parameters in a dynamical system having two functionally distinct but interacting levels. The intergestural level is defined according to a set of activation coordinates; the interarticulator level is defined according to both model articulator and tractvariable coordinates. In the framework of this extended model, coproduction effects in speech are described in terms of the blending dynamics defined among a set of temporally overlapping active units; the relative timing ...


Bartonella henselae infective endocarditis complicated by glomerulonephritis is a rare diagnosis and requires a broad range differential diagnosis. ANCA PR-3 (Antineutrophil cytoplasmic antibodies directed to proteinase-3) is a frequent finding in this clinical setting. We report a patient with PR3-ANCA positive crescentic glomerulonephritis associated with Bartonella henselae infective endocarditis. Antibiotics and corticosteroids after achieving septic control resulted in partial renal recovery. This case underlines the need to exclude ANCA vasculitis in the setting of crescentic glomerulonephritis associated with infective endocarditis and emphasizes the potential role of immunosuppressive therapy after control of infection.


Highly specific effects are shown by different salts on the title reaction. Some salts increase the rate by a factor between ca. two and four, whereas for others the increase is between 30 and over a 1000 times. This is attributed to the formation of highly reactive ion pairs (or triplets), whose formation constants have been evaluated, in some cases, from the kinetic data at constant ionic strength. These ion pairs involve essentially the CrII reactant, and their high reactivity is related to the rate of formation of the precursor complex and/or to the rate of electron transfer within the precursor complex.


6035 Background: Patient transitions during the early phases of cancer care from initial diagnosis through oncology consultation are often poorly coordinated resulting in unmet need, poor continuity, and resultant distress. It has been proposed that better coordination of care during this period would improve the care experience from the patient's perspective. We designed a randomized trial to test a community based nursing lead coordination of care intervention in newly diagnosed breast and colorectal cancer patients. Methods: Cluster randomized control trial in 193 newly diagnosed breast and colorectal cancer patients enrolled through surgical practices within 7 days of cancer surgery in Toronto, Canada. Surgical practices were randomized between a standardized nursing intervention and a control group involving usual care practices. The intervention consisted of a standardized in person supportive care assessment with ongoing supportive care by telephone or in person that included linkage to community s...


ABSTRACT The Christmas tree industry in Norway is increasing and Abies lasiocarpa is, together with Abies nordmanniana, the most common exotic species for Christmas tree production. A. lasiocarpa today constitutes ca. 50% of the fir sold in Norway, and there is high demand for sufficient supply of high-quality seed and knowledge of seed sources with a potential for high Christmas tree quality. Two experimental plots were established to identify seed sources with potentially high survival and satisfactory Christmas tree quality. The high variation in traits on the two sites indicates promising possibilities for further selection of A. lasiocarpa clones for growing Christmas trees in Norway. Selection for late bud break to avoid spring frost is important. Pathogens were not found in any of the studied trials, but are an important factor to consider when selecting seed sources for Christmas trees. Due to the early bud break of this species, it is also of high importance to choose planting sites with minimal risks for spring frost. Good localities are slopes where the frost drains away during cold nights. In eastern Norway, A. lasiocarpa should be used with care in districts and sites where spring frost is commonly occurring.


Background: Pheochromocytoma is a rare adrenaline-producing tumour that arises from adrenal gland. The number of cases are increasing globally each year. Pheochrmocytomas release a hormone called adrenaline which can cause severe health problems such as hypertension (high blood pressure), heart attack, and stroke. They might lead to death if not diagnosed early. Diagnosis of pheochromocytomas can be performed by different biochemical tests like catecholamines, metanephrines, chromogranin A ...etc. Objective: To determine the efficacy of plasma free metanephrines measurements for inclusion and confirmation of pheochromocytoma. Methods: Multiple electronic searches were carried out to determine studies in the English-language. Databases used for this purpose were CINHAL, AMED, MEDLINE, PubMed, ScienceDirect, Google scholar and the Cochrane library. To identify relevant articles, various key terms were used. The articles obtained were published during or after 2005. Moreover, inclusion and exclusion criteria were applied while performing this search. The intervention was plasma free metanephrines and comparison with other biochemical test such as plasma or urinary catecholamines, urinary metanephrines, chromogranin A and deconjugated plasma metanephrines. Results: From forty-four studies, only seven studies corresponded with inclusion and exclusion criteria. The main results of four studies showed that plasma free metanephrines were highly efficient in the diagnosis of pheochrmocytoma compared to plasma catecholamines, epinephrines, urine metanephrines and plasma deconjugated metanephrines. The remaining three studies were displayed totally different findings. Urinary metanephrine, chromogranin A and urinary catecholamines demonstrated high sensitivities and specificities compared to plasma free metanephrines. Certain procedures like fast, abstinence from drugs; supine position should be followed by participants before and during blood and urine collection. Conclusion: Plasma free metanephrines measurements are preferable (superior) in the diagnosis of pheochromocytoma. However, patients need to fast, abstinence from drugs, avoid caffeinated and decaffeinated beverages and blood should be collected in the supine position. Introduction Pheochromocytoma is a rare adrenaline-producing tumor that arises from adrenal gland. Each year about 1,000 new cases are identified in the United States. It causes less than 0.2 % of cases of high blood pressure (hypertension). The growth of pheochromocytomas takes place within the center portion of the adrenal gland called adrenal www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.39


Abstract Background. Some patients presenting with nonshockable cardiac arrest rhythms will subsequently manifest ventricular fibrillation. Their prognosis remains poor despite transition to a shockable rhythm. Quantitative waveform measures assess the electrophysiologic status of the fibrillating heart and predict outcome. Objective. To use waveform measures to compare those who presented initially with ventricular fibrillation (primary group) with those who manifested ventricular fibrillation after initially presenting with a nonshockable arrest rhythm (secondary group). Methods. We conducted an observational study using a convenience sample to compare waveform measures of amplitude spectrum area (AMSA), cardioversion output predictor (COP), and detrended fluctuation analysis (DFA) prior to initial shock between the primary (n = 178) and secondary (n = 28) groups. We produced a primary group matched to the secondary group based on the average waveform values to evaluate the observed versus expected outcomes in the secondary group. Results. Survival was 42% in the primary group and 0% in the secondary group. There was a trend toward more favorable waveform values in the primary compared with the secondary group (9.48 versus 9.29, p = 0.10 for AMSA; 13.75 versus 14.12, p = 0.003 for COP; and 0.36 versus 0.44, p = 0.09 for DFA). The restricted, matched primary group experienced a survival of 37%, compared with 0% for the secondary group. Conclusions. Taken together, the findings suggest that the electrophysiologic status of the heart may be suitable for resuscitation in at least some secondary ventricular fibrillation cases and that other pathophysiology may contribute substantially to the poor prognosis. Alternately, waveform measures may not predict clinical outcomes in secondary ventricular fibrillation.


Objective:To observe the effect of needling different acupoints on the expressions of Kir2.1,Kir2.2mRNA in myocardial cells′transient IKir channel in the rat model of myocardial ischemia,the author designed the research to explore the mechanism about needling acupoints along meridians to treat myocardial ischemia on the level of genes.Methods:With random number table,60 healthy male SD rats were randomly divided into blank group,model group,Neiguan(PC6) point group,Lieque(LU7) point group and neither meridians nor points group(12 rats in each group).Except the blank group,the other four groups had subcutaneous multi-point injection of Isoproterenol Hydrochloride(85 mg/kg) to establish the rat model of myocardial ischemia;while the blank group were injected with normal saline at the same area.Then we gave the rats electro-acupuncture stimulation at the corresponding acupoints once a day.One week later,we detected the expression levels of Kir2.1 and Kir2.2mRNA of the left ventricular applying real-time fluorescence quantitative polymerase chain reaction(Real-timePCR).Results:Compared with the blank group,the expressions of Kir2.1 and Kir2.2mRNA in the model group,Neiguan(PC6) point group,Lieque(LU7) point group,and neither meridians nor points group were significantly reduced(P0.01 or P0.05).Compared with the model group,the Kir2.1 and Kir2.2mRNA expressions of Neiguan(PC6) point group and Lieque(LU7)point group were significantly increased(P0.01 or P0.05).Compared with Neiguan(PC6) point group,the Kir2.1 and Kir2.2mRNA expressions of Lieque(LU7) point group and neither meridians nor points group were significantly reduced(P0.01 or P0.05).Compared with Lieque(LU7) point groups,the Kir2.1 and Kir2.2mRNA expression of neither meridians nor points group was significantly reduced(P0.01 or P0.05).Conclusion:Needling acupoints along meridians can reverse the lower expressions of Kir2.1 and Kir2.2mRNA in the ischemic myocardial cells,which confirmed that needling Neiguan(PC6) along pericardium meridian has specific effects on anti-myocardial ischemia.


Modern reactive software systems turn fine-granular real-time notifications about processes in the physical world into information and knowledge to react in time. Push-based Event-based Systems (EBSs) complement pull-based architectures, such as Service-oriented Architectures (SOAs), and enable enterprises to react to meaningful events in a timely manner. Applications for algorithmic trading, energy-aware reactive data center management, or smart supply chain management are just three examples of reactive systems where information provided by heterogeneous data sources has to be interpreted and where false alarms, missed events or otherwise data of inadequate Quality of Information (QoI) carries a cost.

Whether the QoI of notifications is adequate depends on the purpose, the information is intended to be used for by each receiver. This purpose is application-specific and changes at runtime. Thus, the notion of QoI combines objectively measurable properties of a notification and their application-specific assessment that determines the Value of Information (VoI) for a receiver.
Receiving only data that conforms to their QoI requirements is crucial for reactive applications. Current support for QoI, however, is limited in terms of expressiveness and effectiveness.

In this dissertation, we introduce the concept of expectations, capabilities and feedback as a holistic concept to express, negotiate and enforce QoI requirements at runtime in push-based systems. Participants express requirements and define individual trade-offs between them as expectations; the ability of the system to support properties by adapting itself is captured by capabilities that include the individual costs of participants. Feedback to participants is a central component of our approach and is used to coordinate the adaptation of participants at runtime. We show that our approach is more expressive and supports a wider range of properties than current approaches; our approach actively enforces complex requirements about QoI in an effective way without deteriorating the system's performance.
The work presented in this dissertation contributes to the challenge of runtime QoI support in push-based architectures on a conceptual and practical level.

On the conceptual level, we contribute a generic and extensible model to express and manage requirements about arbitrary QoI properties, algorithms for negotiation and enforcing these requirements at runtime as well as a concept for effective runtime monitoring in a distributed and decentralized EBS. The conceptual part of this dissertation synthesizes and expands approaches devised in pull- and push-based systems as well as in economics into a novel concept to support QoI at runtime in reactive software systems.

On the practical level, we contribute a reference architecture for runtime support of QoI requirements, two prototypes built on a centralized and a decentralized Message-oriented Middleware (MOM), examples for existing applications enhanced with our approach as well as an extensive evaluation of our prototypes built on the industry-strength Apache ActiveMQ platform and the academic REconfigurable Dispatching System (REDS). The evaluation uses industry-strength benchmarks and systems to quantify the benefits and execution costs for participants. The practical part of this dissertation shows the practicability of our approach and quantifies the benefits of actively enforcing QoI requirements using feedback.


The main aim of this paper is to give an idea of how the organizations actually do strategic planning in Research and Development, by keeping in view the proper alignment of resources. In this paper various process of strategic management is being discussed for R and D. the paper highlights the R and D portfolio, technology road mapping to help integrate; monitor and shape R and D strategy in support of corporate strategy. The different point of opinions is discussed under the literature review. The different types of research are also being discussed. Also the impact of research and development strategy in the organizations is being highlighted with the steps of the planning.


Abstract. Land subsidence is a major threat for the livability of deltas worldwide. Mitigation of the negative impacts of subsidence, like increasing flooding risk, requires an assessment of the potential of the deltas' subsurfaces for subsidence. This enables the prediction of current and future subsidence and optimization of sustainable management strategies. In this paper we present a method to determine the amount of compaction within different Holocene deltaic peat sequences based on a case study from the Rhine-Meuse delta, the Netherlands, showing the potential of these sequences for subsidence due to peat compaction.


This study deals with designing and molecular docking a novel lead compound 1-
benzyl-3-benzoylurea and the substituted compounds as antiproliferative agents. The
objective of this study was predicting a more potent antiproliferative agent In order
to achieve the goal , the in-silica activity againts 1-UWH receptor was calculated by
Molegro Virtual Docker 5 and compared with Hydroxyurea as a reference compound.
The result showed that all lead and substituted compounds of 1-benzyl-3-benzoylurea
were more potent than Hydroxyurea. It is highly recommended that all lead and
substituted compounds of 1-benzyl-3-benzoylurea be synthesized further as
antiproliferative agents.


Purpose. Complex training involves the completion of a resistance exercise prior to a plyometric exercise. A classic example is to perform vertical jumps or depth jumps after the completion of a back squat exercise. The term 'complex training' is credited to Verkhoshansky et al. (1973). The present study was conducted to assess the outcome of complex training with low-intensity loading interval on certain physical variables among volleyball infants (10-12 ages). Methods. The sample was twelve volleyball girls at sport Aphrodite club. were classified by two group (experimental group ten girls and control group ten girls), the experimental group was participated in complex exercises to nine weeks , three time weekly, the control group participated in the traditional training. Results. Baseline results showed that: the experimental group had significantly higher than the control group in physical abilities and Significant improvements were observed in power and strength for the experimental group when comparative with the control group. Conclusions. complex exercises with low-intensity loading interval are safe and benefit for power & speed. Recent research suggests that it may be necessary to allow three or four minutes rest between the weight training and Plyometric conditions.


A reliable long-lead (5-15 days ahead) prediction of extreme precipitation cluster is vitally important for regional flooding forecasting. A significant research effort is to develop methods for making longlead flood forecasts using machine learning techniques,as current physics-based numerical simulation models can be extremely complex to account for compounding uncertainty in measurements and modeling. Accurate precipitation forecasts by numerical weather prediction models are limited to a few days lead-time, because non-linearity in the governing equations of the atmosphere creates a sensitive dependence on initial conditions. We design a novel Spatio-Temporal Convolutional Neural Network (ST-CNN) to fully utilize the spatial and temporal information and automatically learn underlying patterns of precipitation precursors from data for extreme precipitation cluster prediction. We validate the ST-CNN model using 62 years historical precipitation data collected in the State of Iowa, USA, from 1948-2010.


Sport tourism has been one of the fastest developing segments of a growing tourism industry, with sporting events comprising an important part of this growth (Ritchie et al., 2002). It is not surprising then that the prominence of sport-related tourism within the tourism industry has been accompanied by growing interest within academia (Gibson, 1998; Gammon & Robinson, 1997, 2003; Higham, 1999, Higham & Hinch, 2002, 2003; Hinch & Higham, 2001, 2003; Gibson, 2003, 2004; Weed, 2006). However, despite such interest, there has been a relative paucity of research undertaken to examine the profile of sport tourists as individuals who consume sport tourism experiences and products (Saayman et al., 2005; Hennessey et al., 2008). This paper addresses one category of sport tourism – that is, event sport tourism – and focuses on those event sport tourists who travel to watch a sporting event (Gibson, 1998, p. 45). In particular, it focuses on an increasingly significant segment of sport tourism – group sport tours, and identifies an equally significant segment of sport tourists – older or 'grey' sport tourists. The paper draws on related studies of sport tourists associated with the sport of rugby union – specifically those tourists, identified as travelling supporters of the New Zealand All Blacks and of the British Lions rugby union teams, who are both spectators and fans – to highlight the nature, characteristics and significance of such grey sport tourists. Our analysis has revealed that the All Black and British Lions sport tourist markets are largely homogeneous, yet have distinctive characteristics, being disproportionately representative of older, wealthier, highly qualified and educated, urbanized males. The paper concludes with suggestions for future research possibilities regarding related sport tourism events, sport tourists' motivations and social/leisure experiences; and also regarding sport spectatorship in New Zealand and beyond.


Objective To investigate the diagnostic value of alpha-fetoprotein(AFP),lectin-reactive alpha-fetoprotein(AFP-L3) and Golgi protein 73(GP73) to the diagnosis of primary hepatocellular carcinoma.Methods Serum AFP was detected by using electrochemiluminescence assay in 102 patients with primary hepatocellular carcinoma,79 patients with benign liver diseases and 31 healthy volunteers.AFP-L3 was detected by using affinitive centrifugal tube in patients with positive AFP(20 μg/L).GP73 was quantitatively analyzed by using ELISA.Results The sensitivities of AFP,AFP-L3 and GP73 were 51.96%,75.50% and 77.45%,and the specificities were 50.63%,93.67% and 71.95% respectively in the diagnosis of primary hepatocellular carcinoma.The sensitivity and specificity of the combined detection of three markers were 95.10% and 93.67% in the diagnosis of hepatocellular carcinoma.The positive rate of AFP-L3 was 96.23% in patients with AFP400 ng/mL,obviously higher than that in those with AFP≤400 ng/mL(53.06%)(P0.05),and there was no significant difference in the positive rate of GP73 between them(75.47% vs 75.51%)(P0.05).Conclusion The combined detection of AFP,AFP-L3 and GP73 can improve the sensitivity and specificity in the diagnosis of primary hepatocellular carcinoma.GP73 is superior to AFP in the early diagnosis of primary hepatocellular carcinoma.


The central goal of this study is to improve understanding of habitual exercise behaviour. First, personal values are linked to individual"s health-related motive orientations (HRMO), and may offer insights into how to promote better any health-related behaviour (e.g., healthy eating, regular exercise, or stress-relieving activities). Second, this paper addresses the effects of personal values on habitual exercise behaviour via two mediators, HRMO and attitude toward exercising, and may provide deeper understanding of the underlying motivations of individuals for regular exercise. Third, this study investigates the independent effects of HRMO on exercise behaviour via attitude toward exercising, checking also if these relationships are moderated by individual"s regulatory focus


MTA® is considered as the biomaterial of choice because of its excellent characteristics. Biodentine™ has been introduced into periapical surgery and has proven its efficacity in sealing root-end cavities. Despite of the desirable properties of BiodentineTM, there are limited published cases that described the use of BiodentineTM in periapical surgery.


The objective of this work is to analyze the atomization and evaporation characteristics of dimethyl ether(DME) fuel for the application of HCCI diesel engine. In order to investigate the spray behavior of DME fuel, the macroscopic and microscopic characteristics were investigated in terms of spray development, spray tip penetration, impingement time, SMD, and axial mean velocity under the various injection timing and ambient conditions. For the illumination of spray, the spray visualization system was composed of a Nd:YAG laser and an ICCD camera and laser-sheet method was used. The atomization characteristics of DME fuel are analyzed by using phase Doppler particle analyzer (PDPA) system It was reveal that the spray development of DME is slower and rapidly disappeared as elapsed time after start of injection at the same injection duration. The impingement timing of diesel fuel was fester than that of DME fuel. The comparison of spray atomization characteristics in both fuels shows that diesel fuel has a large SMD value that DME.


And the execution of the check data validity efficient, the encryption process and prevent leakage of the key material for, illegal use exclusion of content data, the use restriction of the content processing, application, efficiency of reproducing process of the compressed data for the content of the plurality of the data format for the purpose of . Section part by the contrast value checking value part and run the verification processing of the partial data corresponding to a contrast value check part checks the combination of the value part check value set verification part checking value verification check for performing on as to the data set in the content It performs a verify process for the entire data set. In addition, it stores the master key to generate individual keys necessary for encryption processing such as data in the storage unit, and generates the key, if necessary. In addition, the storage device the negative list in the header information of the content, and executes the list of references at the time of data processing used. In addition, the store data processing apparatus specific key and the system common key, and optionally uses the key based on the content use restriction. Furthermore, the connection block, and a plurality of content, at least the encryption process by the content of the block part on the encryption key K and Further, the content data compressed by the data compression program and the decompression processing program or a type of a combination, and reproducing apparatus is made possible is determined for possible expansion processing program applicable to the compressed content.


This case study determined the standard operating procedures of The Peninsula Manila in handling different kinds of threat and the preventive measures and training programs of its security and front office departments. Furthermore, it observed the security procedures being implemented in different facilities of the hotel and to evaluate if their security procedures conform to the general standards set by the hospitality industry. Descriptive-evaluative research was used in the study. Actual observations and interviews with the key informant on the security procedures being implemented in the different facilities of the hotel were done. Results of these procedures were compared to the standards set by the hospitality industry. Findings showed that The Peninsula Manila has a set of standard operating procedures in case different kinds of threat occur. The security and front office departments maintain preventive measures and training programs to keep safety of guests and employees. In fact, the security procedures being implemented in the main entrance, lobby, back-of-the-house hallways, parking lots, service entrance, and outside facilities obtained an excellent rating, for their security procedures exceed the set standards due to the installation of devices that tighten their security measures.


ANOTHER year has been recorded in the history of applied science—a year of increased usefulness almost everywhere, with new research opportunities in many lands and also new scientific trials, especially in Europe. In general, scientific investigation was more beneficial in 1939 than ever before in facilitating and safeguarding traffic along the highway of industrial progress. Even in the warring countries there were found many new technical facts in the side roads to conflict—bright shafts of research accomplishment that in part at least are more significant scientifically than merely as additions to the quivers of combat. In the countries at war the industrial research is, of course, directed by national interest. It is true nevertheless that some of the results of such intense investigation are of widespread permanent value. In the United States industrial research has a pleasant thoroughfare, along which it has kept advancing. The principal results of its progress ...


Proceeding from the considerations of the actual situation of an aluminum smelter,this paper analyzes the quality condition of the waste production water,discusses the new process combination for the waste production water treatment,and tries to blaze a new way for the treatment and recycling of the waste production water.


Abstract This study compared the efficiency of 100% rapid rescreening, 10% random rescreening and rescreening of smears selected on the basis of clinical criteria as methods of internal quality control of cervical smears classified as negative during routine screening and verified whether the results varies according to the adequacy of the sample and the woman's age group. This study included smears of women who were users of the National Health System in the city of Goiânia, capital of the state of Goias. Cytopathology was carried out at the Romulo Rocha Laboratory, School of Pharmacy, Federal University of Goias. Samples were collected using conventional cervical cancer screening techniques. A total of 5,530 smears classified as negative at routine screening were submitted to the 100% rapid rescreening method. In addition, smears were selected based on clinical criteria and were submitted to rescreening. Next, 10% of all negative smears were randomly selected and reviewed. Four cytologists alternated in carrying out the reviews, each sample being reviewed by two of the four.Concordant results were considered as the final diagnosis, while divergent diagnoses were analyzed by a third cytologist, the final diagnosis being defined in a consensus meeting. Cytologists were blinded at all stages and the results were classified according to the Bethesda nomenclature system. For statistical analysis, the variables were evaluated descriptively and were made using the chi-square test. The 100% rapid rescreening method identified 141 suspicious smears, of which 84 (59.6%) were considered positive in the final diagnosis. Of these, 36 (25.5%) were classified as atypical squamous cells of indeterminate significance (ASC-US), five (3.5%) as atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion (ASC-H), 34 (24.1%) as low-grade squamous intraepithelial lesion (LSIL), six (4.3%) as high-grade intraepithelial lesion (HSIL), and three (2.1%) as atypical glandular cells (AGC). Of the 84 suspect smears confirmed in the final diagnosis, 62 (73.8%) smears were classified as adequate and 22 (26.2%) as adequate but with some limitation, but it didn't observe significant difference with the woman's age. The rapid rescreening method classified 19 smears as inadequate, and inadequacy was confirmed in the final diagnosis in 16 (84.2%) of these cases. Of the 1,279 smears reviewed on the basis of clinical criteria, 24 were considered abnormal. Of these, 19 (79.2%) were confirmed positive in the final diagnosis, nine (47.3%) being classified as ASC-US, one (5.3%) ASC-H, eight (42.1%) LSIL and one (5.3%) HSIL. Of the 560 smears submitted to 10% random rescreening, 13 were considered abnormal, six (46.2%) of which were confirmed positive in the final diagnosis, four (30.8%) being classified as ASC-US, one (7.7%) LSIL and one (7.7%) HSIL. However, the 100% rapid rescreening method is a more effective option than 10% random rescreening based on clinical criteria for the detection of false-negatives results in cytopathology internal quality control. In addition, it should be noted that rapid rescreening performed better when the sample was classified as adequate for analysis, however no varies according to the woman's age group. Keywords: cervical cancer; quality control; rapid rescreening; false-negative.


Android apps are popular in our daily life, while the testing and maintenance of them is still an open challenge. Random-based testing tools are time-consuming and model-based testing tools are unrealistic to construct all functional behaviors precisely. Existing testing tools based on reinforcement learning not only have difficulty in understanding the business logic of an application, but also face the problem of state explosion during testing. In this paper, we propose SQDroid, a semantic-driven approach for Android apps based Q-learning. SQDroid encourages the Q-learning agent to prefer the actions with functional semantics through a dynamic semantic reward function, which is beneficial to the understand business logic of an app. A state clustering module, employed to compress the state space in Q-table, utilizes the widget attributes on GUI hierarchy to abstract a state. It can reduce the number of states in Q-table and avoid the execution of repetitive actions. We evaluate SQDroid on 48 open-source Android apps. The results show SQDroid outperforms the state-of-the-art model-based/search-based technique/reinforcement learning-based Stoat, Sapienz and Q-testing in terms of code coverage and fault revelation.


Data mining techniques are implemented in many organizations as a standard procedure for analyzing the large volume of available data, extracting useful information and knowledge to support the major decision-making processes. Data mining can be applied to wide variety of applications in the educational sector for the purpose of improving the performance of students as well as the status of the educational institutions. Educational data mining is rapidly developing as a key technique in the analysis of data generated in the educational domain. The aim of this study presents an analysis of every semester results of UG degree students using data mining technique. The analysis work of this research is based on two models. Model A uses the dataset that contains all the student performance parameters and data mining classification techniques and generated the result based on Accuracy and Error Rate of the classifiers. Model B uses the dataset contains only statistically proved highly affected parameters on student performance and applied data mining techniques on this data sets and generate the results based on Accuracy and Error rate of the classifiers. This research work compare the result of both the model and check that which model is best. The comparison is done using the measurement of accuracy and measurements of Error Rate. This research work also shows that which algorithm is most suitable for predicting the performance of the students among the selected algorithms. The analysis work is done by considering various types of algorithm like decision tree algorithm, rule based algorithm, Bayesian algorithm and function based algorithms. This generic novel approach can be extended to other disciplines as well.


The invention discloses a method for measuring the storage depth of a digital storage oscillograph, which comprises the steps: a. the measured digital storage oscillograph is arranged on a base time threshold which is corresponding to the highest sampling rate in a real-time sampling state, the sparking way is arranged into single sparking; b. a measured signal is input to the measured digital storage oscillograph, and after the single sparking collection is over, according to the displayed time base and the occupied grid numbers of all waveforms on a screen, and according to the formula: the storage depth equals the time base multiplied by the occupied grid numbers of the waveforms multiplied by the highest sampling rate, the storage depth of the measured digital storage oscillograph is obtained. By using the time base threshold setting corresponding to the highest sampling rate in a real-time sampling state and the setting of single sparking, the method for measuring the storage depth of a digital storage oscillograph obtains a section of continuous waveform records, and the storage depth is obtained according to the time and the highest sampling rate of the waveform record, thus the users can choose a suitable digital storage oscillograph to measure signals according to the important technical target of the obtained storage depth of the digital oscillograph.


Purpose
The purpose of this paper is to analyse two questions. First, is there, and if so, how large is the price premium paid for a building exhibiting a cultural value? Second, are there any spillover effects of buildings with cultural values on sales prices of neighbouring houses?

Design/methodology/approach
Using a unique database of all buildings in the region of Halland, Sweden, combined with transaction data, hedonic models can be estimated, with spatially lagged variables describing proximity to three classes of culturally classified building – A, B and C – corresponding to building of national interest, building of regional interest and building of local interest. In addition, the authors also estimate models with a spatial specification on the error term, in an attempt to control for omitted variables.

Findings
The results indicate that cultural classification plays a role in determining the price of a property, with large effects (ranging between 36 and 60% price premiums) for the highest classification. In addition, the authors find evidence of a cultural externality, houses in the vicinity of building with high cultural value sell at a small, but statistically significant premium of 1%.

Originality/value
The cultural externality may be overlooked when it comes to valuation of cultural values in society, and therefore, it is likely that warranted protection acts to preserve cultural values in buildings become less than the social optimum. This paper suggests a new measure to cultural values contrasting previous research that rely on cultural preservation. This approach should limit problems with measurement errors that may lead to biased results.


The author examines the conflict in France between medical paternalism, which preserves the physician's right to withhold information about diagnosis or prognosis from persons who are seriously ill, and the growing support for active euthanasia among the public. Living will legislation was unequivocably rejected by the National Assembly in 1978, yet there is interest in the use of drugs for the relief of pain even if they hasten death, in services to relieve the loneliness of the dying, and in a new emphasis in medical education upon a relation of partnership between doctors and patients.


Machine downtime, whether planned or unplanned, is intuitively costly to manufacturing organisations, but is often very difficult to quantify. The available literature showed that costing processes are rarely undertaken within manufacturing organisations. Where cost analyses have been undertaken, they generally have only valued a small proportion of the affected costs, leading to an overly conservative estimate. This thesis aimed to develop a cost of downtime model, with particular emphasis on the application of the model to Australia Post's Flat Mail Optical Character Reader (FMOCR). The costing analysis determined a cost of downtime of $5,700,000 per annum, or an average cost of $138 per operational hour.

The second section of this work focused on the use of the cost of downtime to objectively determine areas of opportunity for cost reduction on the FMOCR. This was the first time within Post that maintenance costs were considered along side of downtime for determining machine performance. Because of this, the results of the analysis revealed areas which have historically not been targeted for cost reduction. Further exploratory work was undertaken on the Flats Lift Module (FLM) and Auto Induction Station (AIS) Deceleration Belts through the comparison of the results against two additional FMOCR analysis programs.

This research has demonstrated the development of a methodical and quantifiable cost of downtime for the FMOCR. This has been the first time that Post has endeavoured to examine the cost of downtime. It is also one of the very few methodologies for valuing downtime costs that has been proposed in literature. The work undertaken has also demonstrated how the cost of downtime can be incorporated into machine performance analysis with specific application to identifying high costs modules. The outcome of this report has both been the methodology for costing downtime, as well as a list of areas for cost reduction. In doing so, this thesis has outlined the two key deliverables presented at the outset of the research.


The importance of the mathematical notion of concavity in relation to thermodynamics is stressed and it is shown how it can be useful in increasing the enthusiasm of physics' students for their mathematics' courses.


During the 82nd cruise of RV Akademik M. A. Lavrentyev a multidisciplinary study of the ecosystems associated with hydrothermal vents and cold seeps in the Bering Sea was conducted. New data on the composition and structure of benthic communities of the Piip's Volcano are obtained. On the Koryak slope of the Bering Sea, a new cold seep region was discovered. Chemosynthesis-based communities on the Koryak slope are the northern-most of their kind in the Pacific, and the Koryak population of Calyptogena is the northern-most Recent population of pliocardiines in the World Ocean.


This paper proposes a method to automatically derive a reduced order model of the induction machine from the electromagnetic finite-element-analysis. The benefit is a consistent workflow between the detailed designing process of the electrical machine and system level modeling. The basis of the model structure are the differential equations of the induction machine in rotating d-q coordinates. The equations are combined with the nonlinear correlation between current and flux linkage. Therefore a current driven parameter study in the finite-element-analysis is performed. The voltage driven reduced order model is able to start the simulation in steady-state because an initialization process is implemented. The validation results show a good agreement between the reduced order model of the induction machine and the voltage driven finite-element-analysis.


Citizen participation is one of the core issues in democracy. Citizen participation is a necessary and sufficient condition of achieving a constitutional state. Only via citizen participation can people truly realize the highest pursue of constitutional value that people are the real masters of their own country. Concerning to the administrative law, participation rights of administrative counterpart are diffraction rights of citizen constitutional rights. Participation of administrative counterpart is not only the external dynamics of reinventing government, but also is the important content of government improvement of the operational system. Enhancing participation of administrative counterpart and achieving the administration democracy have been becoming the development trend of global public management reform in the new era. Constitutional engineering construction in our country shall keep pace with the times. Based on the relationship between participation rights of administrative counterpart and China constitutional construction, this paper explores careless mistakes. in Chinas participation rights of administrative counterpart and proposes that in constitutional norms, participation rights of administrative counterpart shall be clearly stated and its realization shall be guaranteed.


Everolimus (EVE), an inhibitor of mammalian target of rapamycin, is an emerging second‐line therapeutic option for hormone therapy‐resistant breast cancers. However, some patients do not respond to EVE, whereas in others it exacerbates the disease. Cellular inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that can promote cancer cell growth and apoptosis resistance. Although CIP2A is upregulated in hormone‐related cancers, such as breast cancer, little is known about potential anti‐tumor effects of downregulating CIP2A. As a model to study the resistance of breast cancer cells to hormone treatment, we previously established clones of long‐term estrogen depletion‐resistant MCF‐7 (LTED) cells. Here, we selected three clones highly responsive to EVE and three clones poorly responsive to EVE. When cells were treated with EVE, CIP2A mRNA expression was decreased in highly responsive EVE clones (DC‐cells) whereas it was increased in poorly responsive EVE clones (IC‐cells). Using Kaplan–Meier survival plots, we report that high expression of CIP2A was associated with significantly reduced overall survival in patients with luminal A breast cancer. In IC‐cells, cell growth was enhanced upon EVE treatment whereas an EVE range of 0.1–100 nm decreased growth in DC‐cells. The mRNA expression of genes involved in epithelial–mesenchymal transition (EMT) such as CDH1, CLDN3, and CK19 was significantly decreased in IC‐cells, but remained unchanged in DC‐cells. These findings highlight a relationship between CIP2A and EMT in the intrinsic resistance of hormone therapy‐resistant breast cancers to EVE.


A 34-year-old man presented with progressive visual loss, diplopia, headache, intermittent fever, and significant weight loss for 7 months. Physical examination revealed bilateral visual loss and exophthalmos with complete ophthalmoplegia. Imaging demonstrated pachymeningeal enhancement, soft tissue infiltration in the retro-orbital spaces and multiple organs including kidneys and abdominal aorta, and mixed osteosclerotic and osteolytic lesions in bilateral femoral heads1 (figure). Pathologic study of the retro-orbital lesion revealed foamy histiocytes negative for CD1a and S100,2 consistent with Erdheim-Chester disease (ECD). The patient was treated with IV methylprednisolone followed by cyclosporine with minimal benefit. Four months later, he died due to sudden unexplained death during sleep. An autopsy was not performed. ECD is a rare, non-Langerhans histiocytosis characterized by chronic histiocytic infiltration of multiple organs. Common manifestations include bone pain, diabetes insipidus, exophthalmos, and xanthelasma.1 The nervous system is affected in 25%–50% of patients and can be involved in the extra-axial and intra-axial compartments.1,2 Standard treatment has not been established.