At the end of the 20th century cancer emerged as the second leading cause of death in the USA, exceeded only by cardiovascular disease. Taking into account the emotional and psychological trauma associated with the disease, and the fact that treatment is often as harsh as the disease itself, cancer may be second to none in terms of suffering experienced by those affected. 1 Conventional cancer therapy is designed to reduce the tumour burden locally by means of surgical excision and irradiation, and to eradicate primary and metastatic cancer cells by means of systemic chemotherapy. Because of the significant side-effects of such invasive methods, the emotional trauma of the diagnosis is often magnified by the physical trauma of these interventions. Oncology is therefore a specialty practice in which complementary and alternative approaches may be synergistically employed to reduce the sequelae of the disease itself and to limit the toxicity of disease management. 1 Mind-body medicine, a major area of complementary and alternative medicine (CAM), focuses on the interactions among the brain, mind, body and behaviour and on the powerful ways in which emotional, mental, social, spiritual and behavioural factors can directly affect health. 2


My paper discusses my drawings, paintings, and installations from the first decade of the 2000s, which have grown out of my experience of motherhood as a daughter, being pregnant, and mothering in the postnatal phase. The paper focuses on representation of these experiences in my art making, with specific reference to the nonfigurative expression of my works—that is to say, maternal mothered bodies, including mine, my mother's, as well as my daughter's, are absent in my emotive expression.


He was going … they … gave him the last rites, but then ten minutes later, they came along and resuscitated him, I mean, that's the trouble with hospitals, no liaison.

Alan Bennett, eavesdropping on two northern women, captures the results of a team not working together.1 It could have happened anywhere. Many of us have found that the theoretical elements of interprofessional collaboration are often not achieved in practice.2 Enhanced collaboration needs to be meaningful and effective for patients and their carers.3 Effective teamwork that puts patients' needs at the centre of the care delivered is an essential constituent of future health and social care services.45 It needs …


As a quickly effective measure of modernization forestation,Aerial-seeding forestation in Kubuqi Desert has been an important measure of vegetation restoration and reconstruction in Ordos.Through long term practice,Aerial-seeding forestation has proved:(1) Through Aerial-seeding experimental comparison by setting different size Gordejevii Barrier at Mu Us sandy land,Aerial-seeding species of seedling rate that averagely has a more percentage of 8.9 to 30.2 than other's and 36.5 to 37.1 percentage than CK area has a setting size of gordejevii Barrier that is the even spread type is apart from the 4 metre row or column type checkerboard and erection type to be apart from 6 metre row or column type checkerboard,and its seedling rate is 45.6% and 46.2%.(2) The primed and pelleted seeds treatment of Aerial-seeding seeds have following benefits: increasing the amount of Aerial-seeding seeds' falling,totally with a more percentage of 59 to 86 per area than CK's on average;in the seedling rate.the primed and pelleted seeds with a additional percentage of 13.02;after 15 days of the primed and pelleted seeds' sowing,its root on average is longer than naked seeds by 11.93mm;side number on average is more than naked seeds by 0.9twip/plant,ground path is longer than naked seeds by 0.29mm,and young plant of high is longer than naked seeds by 3.24mm.(3) The condition of environment,preservation young plant is six to eight times than contradistinguish by different seed treat in Kubuqi Desert.


Objective To assess the effect of recombinant human growth hormone (rhGH) on left ventricular function in the treatment of patients with idiopathic dilated cardiomyopathy (IDCM) by randomized, double blind, placebo study. Methods Fifteen patients with IDCM were studied at base line and after three months therapy either with rhGH ( n =10, 4.5 IU QOD, i.m.) or placebo ( n =5). Routine therapy for heart failure was continued. Cardiac function was assessed with two dimensional echocardiography and exercise capacity tesing. Results rhGH improved left ventricular systolic function, left ventricular ejection fraction (LVEF) significantly increased from 27.7±7.0 to 39.7±8.5% (P0 01), left ventricular end systolic dimension decreased from 58.2±7.7 to 54.5±9.2 mm (P0.01). rhGH also improved exercise capacity duration time with significantly increase from 236 3±87 2 to 350 9±102 1 seconds (P0 01). Conclusion rhGH administered for three months to patients with IDCM reduces LV end systolic dimension and improved LV systolic function and exercise tolerance with no adverse events, which need to discontinue the pilot study.


G. Bigras, J. Wilson, L. Russell, G. Johnson, D. Morel and M. Saddik
Interobserver concordance in the assessment of features used for the diagnosis of cervical atypical squamous cells and squamous intraepithelial lesions (ASC‐US, ASC‐H, LSIL and HSIL)


Instituto de Astrof´isica de Andaluc´ia (CSIC), Apartado 3004, 18080 Granada, SpainThe dates of receipt and acceptance should be inserted laterKey words methods: data correction – stars: oscillationsIn Helio- and asteroseismology, it is important to have continuous, uninterrupted, data sets. However, seismic observationsusually contain gaps and we need to take them into account. In particular, if the gaps are not randomly distributed, theywill produce a peak and a series of harmonics in the periodogram that will destroy the stellar information. An interpolationof the data can be good solution for this problem. In this paper we have studied an interpolation method based on theso-called 'inpainting' algorithms. To check the algorithm, we used both VIRGO and CoRoT satellite data to which weapplied a realistic artificial window of a real CoRoT observi ng run to introduce gaps. Next we compared the results withthe original, non-windowed data. Therefore, we were able tooptimize the algorithm by minimizing the difference betweenthe power spectrum density of the data with gaps and the complete time series. In general, we find that the power spectrumof the inpainted time series is very similar to the original, unperturbed one. Seismic inferences obtained after interpolatingthe data are the same as in the original case.


This paper describes the life cycle of a high level cut-off cyclonic vortex that affected southern South America between 26 March and 2 April 2007, and explores the relationship between the evolution stages of the system and the rainfall over central Argentina. The possibility of other processes contributing to rainfall is also analyzed. The most relevant characteristics of this system were its length and slow displacement: from its development to decay it moved only 780 km. During its segregation and mature stages, it remained stationary for over 56 hours along the coast of central Chile. This latter feature favored the establishment of a low pressure system in the northwest of Argentina and the persistence of a northerly low level jet, from the center of Bolivia to the north of Argentina. The air mass with tropical characteristics driven by this system and the low-level convergence contributed to the development of convection. Accumulated rainfall during those stages, in some regions of central eastern Argentina was above 300 mm, producing significant flooding in the region. During the decay phase (96 hours duration), the system weakened as it moved eastward and precipitation affected the provinces of central-western Argentina, where the 48 h rain was twice the monthly average for March.


The Box Hill episode in Emma is significant to understand Jane Austen's thoughts about an ideal community. As an opposing example of the harmonious society shown in Highbury, Box Hill symbolizes chaos and conflict. The climax of the episode is at the moment of Emma's insulting the poor spinster, Miss Bates. Emma's snub upon Miss Bates brings up a question of class distinction. The class system in the community cannot ignore or exclude the rising power, represented by the Coles. On the other hand, it is not wholly based upon money, represented by Miss Bates, who has connections and is on visiting terms with them. With the issue of class distinction, Miss Bates is an interesting figure, who takes a complex role. Her monologues look tedious or irksome, but they prove to be realistic and an impressive creation of the character, and they make the community a whole. Emma realizes what she has to overcome and correct. Consequently, the Box Hill episode plays a decisive role, both for the climax of the novel and for the agreeable conclusion.


The forewing of a termite from Early Miocene lake sediments in Otago, southern New Zealand is figured and described. It exhibits the generic characters of the damp‐wood termite Stolotermes Hägen, but differs from forewings of the known species in size and venation pattern and is described as Stolotermes kupe sp. nov. S. hupe represents the first confident record of fossil Stolotermitidae and extends the fossil record of the family back to the Early Miocene. It also is the first direct evidence of fossil Isoptera from New Zealand, though silicified termite faecal pellets, referable to Kalotermes brauni, have been previously described. S. kupe indicates that Stolotermitidae has been present in the Australasian region since at least the Early Miocene.


This study investigates the output synchronisation of a heterogeneous network of agents affected by parameter perturbations. The authors use the output regulation theory to solve this problem. The main result is the construction of the reference generators and the robust regulators, which can guarantee the outputs of the non-identical agents track the output of the leader. The designed method includes two steps, which can be seen as a kind of separation principle. Firstly, the outputs of a network of local identical reference generators are forced to asymptotically follow the output of the leader. Secondly, under the control of an individual regulator, the output of each agent is forced to track the output of the corresponding local reference generator, via robust output regulation theory.


Abstract During a monitoring programme the diet composition of Asplanchna priodonta was studied. Samples were collected every month from the deepest part of the Dobczycki dam reservoir (Southern Poland). The diet of A. priodonta, which included colonial cyanobacteria, diatoms, dinoflagelates and protozoa, indicated that it is both a grazer and a predator. These results support the hypothesis that A. priodonta is an opportunistic feeder. Additionally these results include the first observations of the protozoan Tintinnopsis sp. as a food source of Asplanchna.


Background: The genus Variovorax sp. PAMC28711 is a cold-adapted microorganism, isolated from Antarctica lichen Himantormia. The complete genomes of six Variovorax species were analyzed and compared along with the strain PAMC28711. The genomic information was collected from NCBI as well as PATRIC databases. Likewise, CAZyme annotation (dbCAN2 Meta server) was performed in order to predict the CAZyme family responsible for trehalose synthesis and trehalose degradation enzymes. The trehalose metabolic pathway was analyzed via the KEGG database. Bioinformatics tools such as OrthoANI software were used to analyze similar genes in different strains under the same genus. Likewise, MEGA X was used for evolutionary and conserved genes.Results: The complete genome of genus V. sp. PAMC28711 was found to comprise CAZyme families GH (10), GT (9), CB (1), AA5 (1), and CE (1). The three trehalose synthetic pathways (OtsA/OtsB, TS, and TreY/TreZ) and trehalose degradation pathway (TreF) were identified only in V. sp. PAMC28711 among the different strains of Variovorax studied, whereas one to two pathways of trehalose biosynthesis, but not trehalose degradation pathways are involved in other Variovorax strains. The strain PAMC28711 comprises of cytoplasmic trehalase (TreF) as a trehalose degrading enzyme that belongs to the CAZyme family GH37, which is not identified in other strains of Variovorax.Conclusions: To date, although the genus V. sp. PAMC28711 has not been reported to exhibit CAZyme activities such as trehalase, and no microorganism expressed different virulence factors, the results based on PATRIC database showed that the strain carried a few virulence genes. Further, this study provides additional information regarding trehalase as one of the factors facilitating bacterial survival under extreme environments and this enzyme has showed potential application in biotechnology fields.


Dr Rebecca CH Brown, PhD, Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK Prof Julian Savulescu, PhD, Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK; Biomedical Ethics Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia; Melbourne Law School, Melbourne University, Melbourne, VIC, Australia Dr Dominic Kelly, PhD, Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Department of Paediatrics, Oxford University Hospitals National Health Service Foundation Trust, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, Oxford, UK Prof Dominic Wilkinson, DPhil, Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK


The new, integrated pilot installation for the investigation of pressure membrane processes, concerning wastewaters has been presented. Its process parameters and main process modules (MF, UF, NF and RO) have been fully described and discussed from the point of view of different applications. Results of the influence of different flows on the process modules as well as the primary results of tannery wastewater purification have been given and discussed.


ABSTRACT Populism is receiving increasing attention and the intrinsic dependency of populism from liberal democracy is being scrutinised to find forms able to contain the populist rise, so far with limited success. Little consideration has been given to the implications that populism is a modern political category that could not emerge without liberal democratic regimes. This article analyses the entanglement between postcolonialism, democratic theory and populism in order to fill this research gap. It focuses on the notion of demagogic populism as a threat to democratic regimes that liberal theories are incapable of contrasting. It analyses in some detail the intercultural democratic discourse (IDD) of M. K. Gandhi, in order to understand to what extent it undermines the populist upsurge and contributes to structuring a substantive and intercultural alternative democratisation theory, with respect to liberal democracy. To cope with the extent of Gandhi's thought, after addressing some limits of liberal multiculturalism, the article focuses on four Gandhian categories: 'civilisation', 'duty', 'non-possession individualism' and 'spirituality'. As Gandhi engaged in the anti-colonial struggle and critical strategic dialogues in intra-civilisational contexts (tradition, religion, caste, modes of production, etc.), he advances a solid IDD, elaborating a groundbreaking vocabulary that includes ashram, satyagraha, swaraj and swadeshi.


Loss spectrum changes for optical fibers exposed to a hydrogen atmosphere in the 15-200\deg C temperature range are measured. Loss increase due to molecular hydrogen dissolved into fibers is investigated from the loss peak at 1.24 μm, and that due to hydroxyl group formation from the loss peak at 1.41 μm. The loss increase due to molecular hydrogen is fully explained by physical solubility theory and diffusion equation. The empirical formula for time, temperature, and hydrogen-pressure dependences of the loss increase due to hydroxyl group formation is evaluated from the experimental results. The loss increase at 1.3- and 1.5-μm wavelength band at room temperature are estimated.


Three sets of kinetic constants and activation energies for each stage of the synthesis reaction N-(adamantyl)acetamide by reacting with 1-bromoadamantane acetonitrile under the action of manganese complexes are found for solving inverse problems of multiparameter. The kinetic model that adequately describes the full-scale chemical experiments based on experimental data obtained at different temperatures, and the numerical determination of the limiting steps was сonstructed. It was established, the limiting step is the formation of 1-adamantyl cation. The calculations were made using mathematical instrument IAAS. The stages of the design and implementation of IAAS were considered. The main calculate units and their interaction were defined. The structure of a database of kinetic studies and tools parallelization of kinetic problems were describes.


In this paper, we consider a downlink communication system where unmanned aerial vehicle base stations (UBSs) assisted ground base stations (GBSs) to provide service, in which both the UBSs and the GBSs follow the independent Poison point process distributions. The air-to-ground channel model is adopted to describe the channel characteristic of UBS to the user equipment. We provide exact expressions for the association probabilities with the UBS/GBS. By applying stochastic geometry method, we derive the explicit expression of overall coverage probability. The simulation results show that the effect of UAV height on coverage probability is not linear. The flight altitude needs to be adjusted according to the base station deployment density to maximize overall coverage.


ii List of Tables v List of Figures vi Chapter One, Introduction 1 Geology/Geography 4 Environment 6 Area Prehistory 8 Chapter Two, Methods 12 Excavation 12 Debitage 16 Faunal Material and Non-Debitage Lithics 23 Multivariate Quantitative Analysis 23 Theoretical Discussion of Hearths 26 Chapter Three, Results 29 Hearth #2 30 Hearth #3 33 Hearth #4 37 Assessment of debitage from the three excavated hearths using the Towner and Warburton method 39 Feature Discreteness and Thermally Altered Rock 40 Face Cleaning 40 Hearth #2 Face Cleaning 41 Hearth #3 Face Cleaning 41


This paper uses nonlinear impulse response methodologies to analyse the relationship between the contemporaneous Nordic/Baltic electric spot prices and wind forecasts. The main objective of the analysis is step-ahead spot price movements from wind forecast information. Dynamic impulse response analysis is a technique for analysing the step-ahead characteristics of a nonparametric estimate of the one-step-ahead conditional density. From strictly stationary processes we build a bivariate price/wind semi-parametric density model. The model estimates report a significant negative non-linear covariance between spot prices and wind forecasts movements in the Nordic/Baltic electricity market. The impulse-response analysis shows that the stepahead contemporaneous co-variance between spot prices and wind forecasts are one important predictor for the spot price mean movements and volatilities. A dynamic nonlinear impulse-response analysis can therefore offer market participants access to dynamic step-ahead spot price mean and volatility strategies. Classification:


Inspired by the rise of Communicative Language Teaching, some scholars have vehemently rejected any use of L1 in L2 learning classes (e.g., Atkinson, 1987) while others have advocated the use of L1 as an efficient tool to facilitate communication (e.g., Nation, 2003). However, caution has been raised against the excessive use of L1 (Nation, 2001). This study was conducted to observe classroom dynamics in terms of the quantity of use of L1 in two randomly-selected pre-university English classes in Ahvaz, Iran. The objective was to seek both students and teachers' perceptions and attitudes towards the use of L1 in L2 classes. The classes were observed and video-taped for 6 sessions and the teachers and four high-achieving/low-achieving students were interviewed. The findings showed that an excessive use of Persian could have a de-motivating effect on students. Hence, the interviewed students voiced dissatisfaction with the untimely use and domination of L1 in L2 classes.


Introduction: Adverse health effects of air pollution on the respiratory system have drawn increasing public health concern worldwide. Previous studies report higher air pollutant exposures could l...


Evolutionary game theory has become a powerful framework to investigate the evolution of cooperation. Games such as the prisoner's dilemma or the snowdrift game are frequently used to model cooperation, and to study its emergence in the context of Darwinian evolution. Until recently, spatial structure was understood as one of the main mechanisms helping the sustainability of cooperation. However, recent results for the snowdrift game have cast serious doubts on the general applicability of this result. Here we show that cooperation may become the dominating strategy, both for the prisoner's dilemma and the snowdrift game, depending on the underlying network of contacts between individuals. By recasting the problem in the framework of graph theory, and associating to the network of contacts graphs of Small‐World and Scale‐Free type, we demonstrate that graphs exhibiting power‐law degree distributions resulting from the mechanisms of growth and preferential attachment provide excellent conditions for cooper...


: A model was proposed to predict separate thermal and mechanical effects of extrusion cooking on thiamin retention. Thermal effects were determined by heating small samples of wheat flour mixed with 0.30% (wt/ wt) thiamin hydrochloride isothermally at 140 °C, 151 °C, and 161 °C for different times. The calculated activation energy and rate constants at each temperature were 67.28 kJ/g mol and 0.00869/min, 0.0145/min, and 0.0224/min, respectively. The "extruder constant" was estimated as 27.7/rev, based on a matching-viscosity method. Wheat flour with 0.30% (wt/wt) thiamin was extruded at different screw speeds. Mechanical effects caused 89.7% to 94.4% of total thiamin loss. This research provides a generalized method to "fingerprint" the extrusion process.


The authors study the external surface of site-percolation clusters in three dimensions by Monte Carlo simulations on a simple cubic lattice at p=pc=0.3117. Their results show that for all cluster sizes, s, more than 99.8% of the occupied sites are on the external surface. The number of unoccupied boundary sites t is found to obey t/s=(1-pc)/pc+As- psi with psi =0.54=1- sigma , in agreement with the prediction of a scaling argument. The same argument also predicts psi =0.60 in two dimensions and it is confirmed. The relevance of these results to dynamical percolation growth models is discussed.


This demonstration introduces UbiComp attendees to a system for content annotation and open-air, social blogging on interactive, publicly situated, digital poster boards using public and personal devices. We describe our motivation, a scenario of use, our prototype, and an outline of the demonstration.


Abstract ONE of the main criteria of consumer acceptance of poultry meat is the tenderness of the product. Numerous factors have been investigated to determine their effect on tenderness. With the introduction of various frozen pre-cooked poultry products on the market, new questions have risen as to the factors contributing to the lack of tenderness in these products. The interval between slaughter and freezing has a marked influence on the tenderness of both chicken and turkey meat (Dawson et al., 1958; Klose et al., 1961). Carlin (1949) observed that freezing increased tenderness considerably in chickens that had been aged less than six hours. Birds that were aged 24 hours were not significantly affected by freezing. Dodge and Stadelman (1959) reported that age of bird, time of aging, class of poultry, temperature of the aging media, and the type of media in which the carcasses were aged all appeared to be important …


The focusing theorem fails for evaporating black holes because the null energy condition is violated by quantum effects. The quantum focusing conjecture is proposed so that it is satisfied even if the null energy condition is violated. The conjecture states that the derivative of the sum of the area of a cross-section of the null geodesic congruence and the entanglement entropy of matters outside it is non-increasing. Naively, it is expected that the quantum focusing conjecture is violated after the Page time as both the area of the horizon and the entanglement entropy of the Hawking radiation are decreasing. We calculate the entanglement entropy after the Page time by using the island rule, and find the following results: (i) the page time is given by an approximately null surface, (ii) the entanglement entropy is increasing along the outgoing null geodesic even after the Page time, and (iii) the quantum focusing conjecture is not violated.


Men of Late Antiquity, whether pagan or Christian, took it for granted that there existed a close relation between political and military success, on the one hand, and the proper worship of the gods (or God) on the other. There is, I believe, a distinction to be drawn, which the author of this book does not mention: whereas for pagans (e.g., Zosimus) the crucial thing was the punctilious performance of certain public rites irrespective of what people did or did not believe in their hearts, for Christians it was rather the adherence to a given doctrine, coupled with a virtuous life. Setting aside this difference, there can be no doubt that the Christianized Empire adopted a 'triumphalist' philosophy: the cross guaranteed victory. If things went wrong, blame was usually laid on the emperor, who bore a collective responsibility for his people.


Based on N-acyliminium species, two efficient and rapid approaches to diversify spirocyclic systems connected by two different carbon centers to the isoindole ring have been developed. The imide reduction and the tandem oxidative cleavage of olefin/formyl-amide equilibration were at first selected as the key steps for these strategies. Ultimately the intramolecular α-amidoalkylation reaction was achieved through the arylation of α-acetoxy lactams or α-hydroxy lactams using, respectively, a Lewis acid or a Brønsted acid depending on the nature of N-acyliminium precursors. The latter led, in addition to the spiro-6-membered aza-heterocycles, to the formation of scarce spiro-5-membered analogues which show promising inhibitory activities on human farnesyltransferase in the nanomolar range demonstrating improved IC50 values of up to 1.5 nM.


Acute fulminant myocarditis (AFM) is a relatively rare diagnosis characterized by heart failure preceded by symptoms of viral infection. Sometimes circulatory mechanical support is required for this catastrophic condition and mortality rate was still high. Adult respiratory distress syndrome (ARDS) was a rare complication of myocarditis in the literature. However, there was limited literature discussing AFM complicated with cardiac arrest and subsequent ARDS formation and the prognosis of extracorporeal membrane oxygenation (ECMO) treatment is unknown. Here we report a case of AFM suffering from cardiac arrest and ARDS formation and successfully treated by ECMO. This rare case reminds physicians that ARDS is still a possible but extremely rare complication of fulminant myocarditis, and ECMO is a lifesaving treatment not only for AFM with profound shock but also for possible ARDS formation.


This work investigates the influence of soil type on electrodialytic remediation (EDR) of lead (Pb). In electrokinetic soil remediation, it is well known that pH is a key factor and that carbonate ...


The KHAPE-HMQV protocol is a state-of-the-art highly efficient asymmetric password-authenticated key exchange protocol that provides several desirable security properties, but has the drawback of being vulnerable to quantum adversaries due to its reliance on discrete logarithm-based building blocks: solving a single discrete logarithm allows the attacker to perform an offline dictionary attack and recover the password. We show how to modify KHAPE-HMQV to make the protocol quantum-annoying : a classical adversary who has the additional ability to solve discrete logarithms can only break the protocol by solving a discrete logarithm for each guess of the password. While not fully resistant to attacks by quantum computers, a quantum-annoying protocol could offer some resistance to quantum adversaries for whom discrete logar-ithms are relatively expensive. Our modification to the protocol is small: encryption (using an ideal cipher) is added to one message. Our analysis uses the same ideal cipher model assumption as the original analysis of KHAPE, and quantum annoyingness is modelled using an extension of the generic group model which gives a classical adversary a discrete logarithm oracle.


Background
Rocky Mountain spotted fever (RMSF) is a deadly tickborne disease disproportionately affecting Arizona tribal communities. While the acute clinical effects of RMSF are well-documented, more complete understanding of the long-term health consequences is needed to provide guidance for providers and patients in highly impacted areas.

Methods
We performed a retrospective review of hospitalized RMSF cases from 2 tribal communities in Arizona during 2002-2017. Medical records from acute illness were abstracted for information on clinical presentation, treatment, and status at discharge. Surviving patients were interviewed about disease recovery, and patients reporting incomplete recovery were eligible for a neurologic examination.

Results
Eighty hospitalized cases of RMSF met our inclusion criteria and were reviewed. Of these, 17 (21%) resulted in a fatal outcome. Among surviving cases who were interviewed, most (62%) reported full recovery, 15 (38%) reported ongoing symptoms or reduced function following RMSF illness, and 9 (23%) had evidence of neurologic sequelae at the time of examination. Sequelae included impaired cognition, weakness, decreased deep tendon reflexes, seizures, and cranial nerve dysfunction. Longer hospitalization (25.5 days vs 6.2 days, P < .001), a higher degree of disability at discharge (median modified Rankin score 1 vs 0, P = .03), and delayed doxycycline administration (6.2 days vs 4.1 days, P = .12) were associated with long-term sequelae by logistic regression.

Conclusions
Although the etiology of sequelae is not able to be determined using this study design, life-altering sequelae were common among patients surviving severe RMSF illness. Delayed administration of the antibiotic doxycycline after day 5 was the strongest predictor of morbidity.


The paper presents results of research on neural network application in forecasting the tensile strength of two types of sutures. The preliminary research was conducted in order to establish the accuracy of the proposed method and will be used for formulating further research areas. The neural network enabled evaluation of suture material degradation after 3-to-6-days' exposure to Ringer's solution. The encountered problems regarding inaccuracies show that developing a single model for sutures may be difficult or impossible. Therefore future research should be conducted for a single type of sutures only and require applying additional parameters for the neural network.


Software testing is an effective means of improving the quality of software.With the expand of the scale of Web application software,the software testing technology research has become a hotspot.The concepts of software testing and the traditional software testing content and method has been introduced briefly in this paper.By comparing the traditional software and Web application software,Web application software testing content and method has been analysed specifically.This will contributes to the software testing technology research based on Web application.


Background Obsessive-compulsive disorder (OCD) is a heterogeneous condition with distinct subtypes. This study aims to compare the severity of obsession and working memory in children with obsessive compulsive disorder and healthy children. Materials and Methods: In this correlation-comparative study, 140 students (70 healthy and 70 with OCD, diagnosed according to Obsessive-Compulsive Inventory, child-version score) were selected through simple random sampling method in in Tehran, Iran, (2018-19).  The multistage cluster sampling method was applied. The subjects were selected after purposeful clinical evaluation and according to the qualifications of the study. Assessments were made using the Obsessive-Compulsive Inventory, child-version (OCI – CV), and the Working Memory Rating Scale (WMRS). Data were analyzed using SPSS software version 25.0. Results: A total of 80 girls and 60 boys with a mean age of 9 ±1.36 years were studied. The correlation between working memory and obsessive-compulsive disorder of girls and boys (r= -0.482; p =0.001) at the level of p Conclusion The findings showed that the working memory scores in both girls and boys increased by reducing the obsessive-compulsive disorder accompanied. Moreover, the working memory of the healthy group was higher than that of the patients.


This paper presents the development and application of a multilevel hierarchical control scheme to the problem of stabilization of a large-scale power system. The control strategy is based on decomposing the control signals into two components ; the first one balances the effect of interactions between the subsystems, while the second is a local controller for the decentralized subsystems. Then stabilization techniques for the design of the local controllers are proposed. The validity of the approach is illustrated through a three-plant electric power system.


? Abstract. In this paper we deene a special class of graph rewrite systems for program analysis: edge addition rewrite systems (Ears). Ears can be applied to distributive data-ow frameworks over nite lattices Hec77] RSH94], as well as many other program analysis problems. We also present some techniques for optimized evaluation of Ears. They show that Ears are very well suited for generating eecient program analyzers.


In the article the author considers the economic activity of linear Cossacks and its reflection in their spiritual culture (based on the example of beekeeping), presented in the archival and ethnographic data, scientific publications of the researchers of various periods (Pre- Revolutionary, Soviet, Post-Soviet). The attention has been drawn to the formation of the branch under the influence of climatic conditions that were new to Cossacks; integration of their experience into economic activity of the neighbouring peoples.


With a deep analysis on the impact of justice of strategic alliance on knowledge sharing,we found that distributive justice and procedural justice have indirect positive impact on knowledge sharing,and it was mediated by relational commitment.This conclusion discovered the relationship between alliance justice and knowledge sharing from a new vision,and it made a new contribution to the development of strategic alliance management.


Nitration of iodobenzene, o-iodotoluene, and p-iodotoluene in acetic anhydride results in reversible oxidation to aryliodine(III) compounds prior to the formation of the expected nitro derivatives. µ-Oxo-[nitrato(phenyl)iodine][phenyl(trifluoroacetato)iodine] has been isolated from nitration of iodobenzene and its crystal structure determined.


A multipoint liquid level sensor based on the RI modulation of macrobend polymer optical fiber (POF) couplers is proposed. By twinning two twisted POFs around a race-track column, a series of U-shaped sensing heads are achieved. The output power in the passive fiber declines in a step form while the sensing heads are immersed into liquid in turn. The introduction of UV optical cement in the gap between two POFs improves the side-coupling ratio, increasing the attenuation per step. For the measurement range of 100 cm, the resolution is 2 cm. The sensor can differentiate different liquids with low temperature dependence.


Decellularized tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications, and more recently decellularized organs have been utilized in the first stages of organ engineering. The protocols used to decellularize simple tissues versus intact organs differ greatly. Herein, the most commonly used decellularization methods for both surgical mesh materials and whole organs are described, with consideration given to how these different processes affect the extracellular matrix and the host response to the scaffold. J. Cell. Biochem. 113: 2217–2222, 2012. © 2012 Wiley Periodicals, Inc.


Abstract Electrical and ultrasonic borehole images along with sonic logs can be used to characterize fracture systems. For electrical imaging tools, algorithms exist to determine from Rm and Rxo the fracture aperture, fracture continuity, the frequency with which fractures intersect the borehole wall (fracture density) and, from these values, the fracture porosity of the formation. Electrical image methods, however, assume that all conductive fractures are open and can transmit fluids. In reality, the majority of fractured reservoirs flow hydrocarbons from only a few isolated fractures, or else from a specific fracture "set" or "system". The picture is further complicated by clay-filled fractures that are difficult to distinguish from open fractures on both electrical and acoustic images. Sonic Stoneley wave analysis from low frequency sonic logging modes provides a key analytical tool that is complimentary to the image logs. Stoneley waves are essentially insensitive to non-productive fractures. Open fractures that extend significant distances from the borehole are easily identifiable. Relative intensity and size of fracturing are also easily observed on the Stoneley analysis, though the vertical resolution of the Stoneley measurement is lower than that of the borehole imaging tools. The methodology is firstly to identify zones of open fractures on the Stoneley analysis, then evaluate the orientation and density of fractures using a higher resolution image log. Sonic cross-dipole measurements can locate vertical fractures and indicate tectonic stress imbalance direction. Examples from Indonesia are presented, in which sonic logs and borehole images combined have been used to characterize fractures in reservoir lithologies that include igneous and metamorphic basement, interbedded volcanics and volcaniclastics, and limestones. The conclusions are, in a number of these examples, supported by production tests.


The ferrielectric subphases of the liquid crystal MHPOBC [4-(1-methylheptyloxy-carbonyl) phenyl 4′-octyloxy- biphenyl 4-carboxylate] were examined by an optical retardation technique as functions of temperature, applied electric field, and cell thickness. We found that thinner cells exhibit more field-induced ferrielectric steps than do thicker cells. This appears to be a universal phenomenon for all ferrielectric subphases.


Fossil fuels are a major contributor to climate change, and as the demand for energy production increases, alternative sources (e.g., renewables) are becoming more attractive. Biofuels such as bioethanol reduce reliance on fossil fuels and can be compatible with the existing fleet of internal combustion engines. Incorporation of biofuels can reduce internal combustion engine (ICE) fleet carbon dioxide emissions. Bioethanol is typically produced via microbial fermentation of fermentable sugars, such as glucose, to ethanol. Traditional feedstocks (e.g., first-generation feedstock) include cereal grains, sugar cane, and sugar beets. However, due to concerns regarding food sustainability, lignocellulosic (second-generation) and algal biomass (third-generation) feedstocks have been investigated. Ethanol yield from fermentation is dependent on a multitude of factors. This review compares bioethanol production from a range of feedstocks, and elaborates on available technologies, including fermentation practices. The importance of maintaining nutrient homeostasis of yeast is also examined. The purpose of this review is to provide industrial producers and policy makers insight into available technologies, yields of bioethanol achieved by current manufacturing practices, and goals for future innovation.


Construction and healthy development of forestry cooperation organization is a burning question since collective forest tenure reform in China,and it is a game process substantially.A 2-phases game model between individual and colony was build to analyze game behavior in the construction and development process of forestry cooperation organization.The results showed that: since player's rationality is different,the external effects in forestry production are pronounced and the harvest takes a long term,the cooperation should be formed based on not only improving the long-term profit and raising the public awareness but ensuring the immediate profit.Besides,external effect is an important factor to influence the cooperation.The paper gives suggestions on the construction and development of forestry cooperation organization.The cooperative content and form should be diversified to ensure farmer's immediate profit,more precisely,training the large forestry and farming households to raise the management level,and giving more publicity to the long-term awareness so as to increase long-term benefit.We must face up to the phenomenon of hitchhike which is difficult to avoid.All measures to reduce risk will propitious to cooperation.During the beginning phase of cooperation,government is an driving force,and policy support and government supervision should be strengthened.


The design, fabrication, and characterization of a frequency-reconfigurable antenna for the United States Public Safety (PS) wireless communication applications are presented. This antenna is quad-band operating in the PS bands-220, 470, 800, and 4960 MHz. It is an electrically small antenna with calculated ka ~ 0.55 at 220 MHz. The antenna has two reconfigurable modes of operations. In mode 1, 220-, 470-, and 4960-MHz bands are excited. Mode 2 provides operation over 800- and 4960-MHz bands. This dynamic frequency reconfiguration is accomplished by two radio frequency microelectromechanical systems switches strategically located within the antenna architecture. The measured and simulated results for impedance and radiation characteristics agree well, where ~ 3%, 4%, 21%, and 17% fractional bandwidths have been measured in the four bands, respectively, while maintaining integrity of radiation pattern.


At the recent AusAID sponsored UN Strategy and Coordination Conference on the Regional Capacity to Protect, Prevent and Respond, the UN Secretary General's Special Representative on Responsibility to Protect (R2P), Edward Luck, noted that while the three pillars of R2P are becoming better known, 90% of the academic work is on pillar III (intervention), even though it is comparatively rare. In contrast we know much less about Pillar II: The Responsibility to Assist.


Proposes a learning-based spatio-temporal vehicle tracking and indexing framework.Intro-duces background subtraction method and SPCPE,it can obtain the Spatio-Temporal re-lation between objects.It also uses multimedia augmented transition network model,and multimedia input strings to index and model their spatio-temporal relations.


The three exploratory case studies discussed in this article were drawn from a Civic Corps project at a public regional university and reveal challenges and obstacles that can disrupt the academic careers of Black male collegians. These barriers include the following: (1) University structures and disciplinary hegemony can suppress the needs of first-generation Black students, preventing the university community, and higher education institutions in general, from "hearing" how we might support them and enable their success; (2) first-generation Black students might require legal services to address conditions off campus that could undermine their persistence and success; and (3) university structures can fail to recognize the dramatic achievements and abilities of Black students. This article highlights how these structural obstacles, which are compounded by cultural, racial, and economic conditions, can be remediated through civic engagement and service-learning, organized by mentors sensitive to the financial, legal, and social needs of young Black men. Building on the minor success of the Civic Corps project, this article hopes to seed more research and to improve institutions' ability to acknowledge the persistence of inequity and to provide Black students resources and access to programs that include civic engagement and service-learning.


We present a systematic study of the variations of the {sup 7}Li NMR properties versus magnetic defect concentration up to 0.83 mol% within the spinel structure of polycrystalline powder samples and a collection of small single crystals of LiV2O4 in the temperature range from 0.5 to 4.2 K. We also report static magnetization measurements and ac magnetic susceptibility measurements at 14 MHz on the samples at low temperatures. Both the NMR spectrum and nuclear spin-lattice relaxation rate are inhomogeneous in the presence of the magnetic defects. The NMR data for the powders are well explained by assuming that (i) there is a random distribution of magnetic point defects, (ii) the same heavy Fermi liquid is present in the samples containing the magnetic defects as in magnetically pure LiV2O4, and (iii) the influences of the magnetic defects and of the Fermi liquid on the magnetization and NMR properties are separable. In the single crystals, somewhat different behaviors are observed. Remarkably, the magnetic defects in the powder samples show evidence of spin freezing below T {approx} 1.0 K, whereas in the single crystals with similar magnetic defect concentration no spin freezing was found down to 0.5 K. Thus different types of magneticmore » defects and/or interactions between them appear to arise in the powders versus the crystals, possibly due to the substantially different synthesis conditions of the powders and crystals.« less


Calculation of equilibrium condensation sequence [1,2] suggests formation of hydrous phyllosilicates in the solar nebula at T < 400 K. Lewis [I] suggested that hydrous phyllosilicates that had formed from the equilibrium condensation of the solar nebula provided the original source of water in the region between Mars and Jupiter, including the asteroidal parent bodies of the meteorites. In a series of papers, Fegley and Prinn [3, 4, 5, 61 explored the kinetics of formation of hydrous phyllosilicates, and concluded that the time scale of formation of these minerals in the solar nebula is > 1017 s, which is >lo4 times the life time of the solar nebula. They have, thus, concluded that the hydrous minerals present in the planetary and asteroidal bodies had not formed by nebular condensation, but instead represent secondary alteration products of the anhydrous grains. The conclusion of Fegley and Prinn have inspired models of large scale aqueous alterations in the asteroidal parent bodies of the carbonaceous chondrites [7, 81 to account for the formation of the hydrous phyllosilicates that are commonly found in these meteorites, and are also inferred to be present in the parent bodies from their reflectance spectra. In this work, we present a critical evaluation of the works of Prinn and Fegley, and show that the available data on phyllosilicate reaction kinetics do not preclude the formation of these minerals within the life time of the solar nebula. The kinetics of formation of hydrous minerals in the solar nebula is also of great importance with regard to the question of water in the earth's mantle. If these had formed during nebular condensation, then they would have become a part of the mineralogy of the earth's mantle through the planetary accretion process, which have important ramifications in the understanding of many terrestrial processes. Fegley and Prinn [3, 4, 5, 61 considered the following reactions with regard to the formation of hydrous phyllosilicates in the solar nebula: (a) 4 Enstatite + 2 H 2 0 = Brucite + Talc, and (b) 2 Forsterite + 3 H 2 0 = Brucite + Serpentine. Using a simple collision theory (SCT) approach for the hydration of monomineralic grains, they derived an expression for the time scale (t) of formation of the phyllosilicates through interaction of the vapor phase in the solar nebula with monomineralic silicate grains as t .= toJexp(-QIRT), where Q is the activation energy of the hydration process, R is the gas constant, and &,, is the collision time constant which is related to the molecular number density and partial pressure of water vapor, and molecular weight of water. Using this formulation, we illustrate in Fig. 1 the time scale of formation of hydrous phyllosilicates as a function of the activation energy of the hydration process at a nebular condition of bars, 225 K. From indirect evidences, Fegley and Prinn concluded that the hydration processes represented by the reactions (a) and (b) are characterized by activation energies of 70 kJ/mol, which require time scale of formation of the hydrous phyllosilicates far in excess of the life time of the solar nebula (Fig. 1). Fegley and Prinn seemed to have been unaware of the work of Wegner and Ernst [9], who studied the kinetics of both forward and backward reactions of (b). Their experimentally determined activation energy for the hydration of olivine to brucite and serpentine is 25


Among translation issues, poetry translation is the most problematic area challenging both translators and authorities in the field of translation...


The invention relates to a preparation method of composite oxide of cerium oxide and tin oxide, which is characterized in that cerium rare earth sol and tin sol are precipitated by alkali liquid, and the composite oxide is prepared by calcining, ball-milling, drying and airflow crushing precipitate. The obtained composite oxide is nanocrystalline cerium-tin compound which has the average agglomerated particles of 100-200nm. The preparation method leads particle agglomeration to be effectively dispersed, and the obtained cerium-tin compound has small grain size and environment-friendly technique, so that the problem of organic wastewater caused by preparation of nano powder can be solved, the technique preparation window is enlarged, and large-scale production can be easily realized.


Evidence is limited for many prenatal care delivery elements, including visit frequency, routine pregnancy assessments, and telemedicine. OBJECTIVE: To perform a literature review of key aspects of prenatal care delivery to inform new guidelines. DATA SOURCES: A comprehensive review of Ovid MEDLINE, Elsevier's Scopus, Google Scholar, and ClinicalTrials.gov. METHODS OF STUDY SELECTION: We included studies addressing components of prenatal care delivery (visit frequency, routine pregnancy assessments, and telemedicine) that assessed maternal and neonatal health outcomes, patient experience, or care utilization in pregnant individuals with and without medical conditions. Quality was assessed using the RAND/UCLA Appropriateness Methodology approach. Articles were independently reviewed by at least two members of the study team for inclusion and data abstraction. TABULATION, INTEGRATION, AND RESULTS: Of the 4,105 published abstracts identified, 53 studies met inclusion criteria, totaling 140,150 participants. There were no differences in maternal and neonatal outcomes among patients without medical conditions with reduced visit frequency schedules. For patients at risk of preterm birth, increased visit frequency with enhanced prenatal services was inconsistently associated with improved outcomes. Home monitoring of blood pressure and weight was feasible, but home monitoring of fetal heart tones and fundal height were not assessed. More frequent weight measurement did not lower rates of excessive weight gain. Home monitoring of blood pressure for individuals with medical conditions was feasible, accurate, and associated with lower clinic utilization. There were no differences in health outcomes for patients without medical conditions who received telemedicine visits for routine prenatal care, and patients had decreased care utilization. Telemedicine was a successful strategy for consultations among individuals with medical conditions; resulted in improved outcomes for patients with depression, diabetes, and hypertension; and had inconsistent results for patients with obesity and those at risk of preterm birth. CONCLUSION: Existing evidence for many components of prenatal care delivery, including visit frequency, routine pregnancy assessments, and telemedicine, is limited.


Article is devoted to the discussion between continental and analytical philosophy, concerning the defi nition of the essence of analytical philosophy, its sources and founding fathers, change in its installations, the positions of contemporary followers, as frameworks of analytical philosophy. The matters for dispute are, most importantly, philosophical logic, methods of analysis, philosophy of language, acceptability of its methodological installations in theory and in practice. Refs 27.


The unique photoelectric properties of phosphorene typically include anisotropy, hence the nondestructive and rapid identification of its crystal orientation is a key point to the investigation and application of phosphorene. Currently, the orientation identification by analyzing the Ag1 mode based on parallel-polarized Raman has severe requirements for the applicable Raman system. Therefore, it is necessary to develop a more general, convenient, and accurate method for determining the crystal orientation of phosphorene. In this paper, a method of orientation identification was proposed by using a Raman system without an analyzer and quantifying the correlation between the intensities of Ag1 and Ag2 modes with the change of the incident polarization direction. By using mechanically peeled phosphorene as specimens, Raman measurements were carried out under the Raman configurations of both parallel polarization and with no analyzer. The results show that the crystal orientation of phosphorene can be accurately identified by quantifying the Raman intensities of both Ag1 and Ag2 modes using the Raman system without an analyzer.


Much work has been undertaken and published on ionospheric modeling for Wide Area DGPS (WADGPS) systems such as the FAA-sponsored Wide Area Augmentation System (WAAS). In mid-latitude regions, typical spatial and temporal variations in ionospheric delay tend to be minimal, and proposed ionospheric models can be broadcast as a set of grid node values along with associated error bounds. Outside of these nominally "quiet" regions however, specifically in the equatorial and auroral zones, the ionosphere is considerably more active, with greater variability both in time and space. Scintillation effects caused by rapid fluctuations in ionization are more prevalent in these zones, and as such, the mitigation of ionospheric delay effects in any WADGPS system which seeks to cover the low or high latitudes may require a more sophisticated modeling process than that for mid-latitude regions. As part of research being carried out at the University of New Brunswick on propagation media effects on WAAS, we are examining the requirements for extending and augmenting the WAAS ionospheric modelling approach to cover Canadian airspace. This work involves identifying and evaluating particular algorithms for the creation of ionospheric delay values and associated error bounds in geographical areas in, and close to, the active auroral zone. In this paper we will identify the specific problems that are associated with ionospheric modelling at high latitudes and over the range of solar activity intensities. Proposed augmentations to be considered include dynamic shell height modelling to enable better performance during auroral storms, and denser grid spacing to take account of larger spatial gradients in the auroral zone. An analysis of grid point availability is presented, showing the limited coverage afforded in northern Canada by the current reference receiver networks. INTRODUCTION As part of a study for the investigation of atmospheric effects on the use of WAAS in Canadian airspace, the University of New Brunswick is currently researching the suitability of the currently proposed ionospheric modeling scheme. Presented here are initial results of these analyses. IONOSPHERIC MITIGATION TECHNIQUES IN WAAS The ionospheric modeling scheme proposed for use in the Wide Area Augmentation System has been described extensively elsewhere [see, for example, Van Dierendonck and Enge , 1994; Conker et al , 1995; and Chao et al, 1996] and so only a brief outline is provided here. It will however, be useful to describe the current proposals as outlined by the FAA [1997], touching specifically on the limitations encountered at northern latitudes. In the WAAS scheme, a network of constantly observing GPS receivers at precisely known locations send dual frequency carrier phase and pseudorange observations back to one or more central processing facilities. There, estimates of the delay imparted by the ionosphere along the line of sight from each receiver to each satellite observed are calculated. Interpolation of these measurements to a pre-defined set of grid nodes (ionospheric grid points (IGPs)), at a designated height of 350km, provides a series of ionospheric delay estimates which may be transmitted to users equipped with suitably modified single frequency GPS receivers. The intersection of the line of sight from receiver to satellite and the shell defined by the IGPs is known as an ionospheric pierce point (IPP). The user is then required to interpolate the grid node delays to the location of his IPPs. These estimates can then be used to correct for ionospheric delay. Estimated along with the grid delays is a bound on the residual error of the vertical ionospheric delay at each IGP. These grid ionospheric vertical error (GIVE) values are used to compute the user ionospheric vertical error (UIVE), the corresponding bound on the user-computed vertical ionospheric delay error. The grid spacing currently proposed for WAAS calls for a five degree grid at mid latitudes, expanding to a ten degree node separation beyond 55 degrees north. Beyond 75 degrees, there are only four IGPs, located at 85 degrees latitude and spaced 90 degrees in longitude [ FAA, 1997]. The original rationale behind increasing the grid spacing at northern latitudes was due to the general decrease in longitude spacing as latitude increases. Figure 1 illustrates the proposed grid node locations over Canada and nearby areas.


By analyzing the current status of application of shunting safety protection system and corresponding technologies in China Railways, it is proposed to take various measures to establish a continuous control system to improve storage of rolling-stocks, precisely identify train length, consummate series of functions like recording, analyzing, review, remote monitoring, etc, thus the design thoughts and technological realization measure on shunting safety protection system are formed.


Generally textile effluents are highly coloured, contain non-biodegradable compounds and they have high content of solid wastes, comprising fibres and paper wastes. The discharge of such effluents in the environment is worrying for both toxicological and esthetical reasons. The aim of the present work is to study the performances of the combining microfiltration-adsorption process for the treatment of coloured waters. Methylene Blue (MB) was used as model compound. The effects of significant operating parameters such as transmembrane pressure (TMP) and bentonite concentration on the process performance characterized by flux and rejection factor were investigated. Experiments carried out with Methylene Blue solutions confirmed the potential of this combined process for the treatment of dyed waters.


SUMMARY Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.


The neutron flux in a nuclear reactor considered as a one-region, bare and homogeneous system with no delayed neutrons is described by a semilinear parabolic equation in a cylindrical region. A generalization of this equation subject to the first initial boundary condition in a region which can be noncylindrical is studied. Global existence of maximal and minimal solutions is established by using iteration schemes of the chord type, which give respectively one monotone nonincreasing sequence of upper bounds and one monotone nondecreasing sequence of lower bounds. Conditions under which uniqueness of the solution occurs are also given. With this, the above two sequences are shown respectively to converge uniformly and geometrically to the solution. It is also proved that the iteration scheme of the Picard type gives an alternating sequence consisting of two monotone subsequences of upper and lower bounds. This sequence is shown to converge uniformly and geometrically to the solution. Finally, the quasiline...


Cilostazol is an inhibitor of phosphodiesterase type III that possesses both antiplatelet and vasodilator effects. The present study aimed to determine the vasodilator effect of cilostazol in eNOS deficient (eNOS−/−) mice. Mouse aorta was contracted with sub‐maximal concentration of phenylephrine and concentration‐dependent relaxations to cilostazol (10−8–10−5 mol/L) were obtained in aortic rings, isolated from wild type and eNOS−/− mice. As previously reported, in aortas of wild type mice with intact endothelium, relaxations to cilostazol were significantly augmented as compared to aortas without endothelium. Surprisingly, genetic inactivation of eNOS significantly enhanced relaxations to cilostazol suggesting that chronic loss of nitric oxide may unmask compensatory vasodilator mechanisms significantly enhanced by the treatment with cilostazol. The augmentation of relaxations to cilostazol in aortas of eNOS−/− mice was endothelium independent and not inhibited by indomethacin, a cyclooxygenase inhibitor. Our findings support the view that patients suffering from vascular endothelial dysfunction induced by reduced availability of nitric oxide, may exhibit enhanced vasodilator reactivity to cilostazol.


The following paper is about the influence Pope John Paul II. had on domestic political occasions in Poland, particularly between 1980 and 1983. His first journey to Poland was a significant impulse for further events relating to the end of the Cold War. He supported the union Solidarnośc and when the law of war was declared in December 1981 he asked Jaruzelski to quit it. John Pauls second visit in 1983 brought political stability back again and soon after the law of war was stopped.


This article deals with self-setting and injectable calcium phosphate cements (CPC) for the application as bone replacement materials. Currently available cements are only indicated for non-load bearing applications. A broadening of the indication for which the cements can be used to load-bearing defects, e.g. in vertebroplasty, would require materials with higher strength and sufficient injectable properties. The article reviews current developments in the field of calcium phosphate cements. The main foci are the reactivity of calcium phosphate compounds in self-setting cement formulations, the rheological properties of the cement pastes for a minimal-invasive application and the mechanical performance of the hardened cement matrix, which is crucial for a broadening of the indication to low-load bearing defects. Literatur [1] Aaboe M., Pinholt E. M., Hjortinghansen E.: Healing of experimentally created defects – a review, Brit. J. Oral Maxillofac. Surg. 33 (5): 312–318, 1995. [2] Hench L. L., Andersson Ö.: Bioactive glasses, An introduction to bioceramics, Hench LL, Wilson J (ed.), Singapore: World Scientific, 1993. [3] Kay J. F.: Bioactive surface coatings for hard tissue biomaterials, CRC Handbook of Bioactive Ceramics 2: 111–122, 1990. [4] Schmitz J. P., Hollinger J. O., Milam S. B.: Reconstruction of bone using calcium phosphate bone cements: a critical review, J. Oral Maxillofac. Surg. 57(9): 1122–1126, 1999. [5] Hench L. L.: Ceramics, glasses, and composites in medicine, Med. Instrum. 7(2): 136–144, 1973. [6] Zitzmann N. U., Rateitschak-Pluss E., Marinello C. P.: Treatment of angular bone defects with a composite bone grafting material in combination with a collagen membrane, J. Periodont. 74 (5): 687–694, 2003. [7] Ramshaw J. A. M., Werkmeister J. A., Peters D. E.: Collagen as a biomaterial, Current perspectives on implantable devices 1990, 2, Williams D.F. (ed.), London: Jai Press Ltd., 151–220. [8] Vert M., Li S. M., Spenlehauer G., Guerin P.: Bioresorbability and biocompatibility of aliphatic polyesters, J. Mater. Sci.: Mater. Med. 3, 432–446, 1992. [9] Gross K. A., Berndt C. C.: Biomedical application of apatites, Phosphates: Geochemical, Geobiological, and Materials Importance Reviews In Mineralogy & Geochemistry 48: 631– 672, 2002. [10] Hench L. L.: Bioceramics, J. Am. Ceram. Soc. 81 (7): 1705–1728, 1998. [11] Elliott J. C.: Structure and chemistry of the apatites and other calcium orthophosphates, Amsterdam London New York Tokyo: Elsevier, 1994. [12] Epple M., Dorozhkin S. V.: Biological and medical significance of calcium phosphates, Angew. Chem. Int. Ed. 41: 3130– 3146, 2002. [13] LeGeros R. Z.: Calcium phosphates in oral biology and medicine, Karger, Basel, 1991. [14] Ravaglioli A., Krajewki A.: Bioceramics Materials, properties, applications, Chapman & Hall, London 1992. ARBEITEN ORIGINAL U. Gbureck: Mechanische und rheologische Eigenschaften mineralischer Knochenzemente Priv.-Doz. Dr. rer. nat. Uwe Gbureck Korresponzanschrift: Priv.-Doz. Dr. rer. nat.


Data visualisations help us process large volumes of complex data faster. The goal of this thesis is to implement visualizer plugins into the Linked Pipes Visualization Assistant – a platform for visualising graph data published in the RDF format. The Assistant automatically analyses data sources and matches them against available visualizers to create interactive views. All visualizers allow configuring the visualisation, saving the configuration and publishing created views. The first group of visualizers works with time-oriented data, viewing instants and intervals on a timeline chart. The second group of visualizers views map-oriented data on the Google Maps. Resources with coordinates are visualised using markers, while resources with coordinates and quantifiers are shown as circles (the circle radius corresponds to the quantifier).


With 21th century coming,the external environment of the enterprise requires the enterprise to improve its adaptability and strengthen its competitive advantage by effective knowledge innovation. Cluster is useful to improve its members' ability of knowledge innovation. It analyzes the promotional effect of cluster to the knowledge innovation. Then it puts forward some policy suggests for developing China's cluster economy.


This paper addresses the integration of pedagogy and technology in science teaching. For a teacher to grow professionally continuous effort is required.  To prepare students for the science and technology for the future, the current science education reforms ask science teachers to integrate technology and inquiry-based teaching into their instruction. Good teaching starts with reasoning and continues with imparting and involving. To make effective pedagogical decisions regarding what to teach and how to teach it, teachers should develop both their Pedagogical Content Knowledge (PCK) and pedagogical reasoning skills. Here the role of science education, the aim of science education, purpose of science education, changing trends in science education, meeting the changing needs in science education, role of Information and Communication Technology (ICT) in transforming teaching and learning, the link between ICT and pedagogy has been discussed. At the conclusion it states that though integration of technology and pedagogy is essential for better science teaching but a balance between pedagogy and technology is required to avail the greatest benefit.


The monumental production by the French painter George Desvallieres (1861-1950) has long been misunderstood, as shown by the absence so far of a comprehensive review. Therefore, not only the compilation of a real catalogue became inevitable and necessary, but above all putting the artist's monumental and decorative works into the context of his and the historical, artistic and religious events of his time. By the 1890s, Desvallieres turned to monumental decorative panels with an iconography that was until 1914 limited to secular themes. His production takes a very different scale after the Great War. His son's death in battle, in 1915, and the vow the artist took in the trenches in 1916 to devote himself exclusively to religious paintings are historical and iconographic markers of the second part of his career. The years 1918-1950 will be those of his greatest achievements in monumental works: fresco paintings, marouflages, stained glass and tapestries, as well as monumental votive offerings are all media he is exploiting to paint a mysticism of the Great War where the Poilu , the French soldier, and the nurse are jointly depicted with great religious figures. The creation with Maurice Denis of the Ateliers d'Art sacre , the Sacred Art Workshops in 1919, demonstrates the important role the two artists assigned to the decorative arts. Desvallieres promotes its development at the Salon d'Automne , which he presides from 1935 onwards, as well in juries and exhibitions in France and abroad. The study of large decorative ensembles of the artist is a valuable addition to the research on decorative arts of the first half of the Twentieth Century and contributes to the First World War Studies as we are approaching the upcoming centennial anniversary.


The minimum cut criterion favors cutting small sets of isolated nodes in the graph,this paper propose a parametric minimum cut method to avoid it.Image segmentation based on graph method is not efficient when the number of the nodes is huge.This paper presents a novel graph-based SAR image region segmentation method with split-merge algorithm.The proposed method has two advantages,one is containing global information by using parametric minimum cut criterion to merge regions and the other one is greatly reducing nodes of the graph by using regions as nodes to create the graph.When splitting a SAR image into many regions according to its gray value,this paper gives a new homogeneity measurement of region to restrain speckle.The experiment results show the effectiveness of the approach.


In this work the electrical activity in brain or known as electroencephalogram (EEG) signal is being analyzed to study the various effects of sound on the human brain activity. The effect is in the form of variation in either frequency or in the power of different EEG bands. A biological EEG signal stimulated by Music listening reflects the state of mind, impacts the analytical brain and the subjective-artistic brain. A two channel EEG acquisition unit is being used to extract brain signal with high transfer rate as well as good SNR. This paper focused on three types of brain waves which are theta (4-7 Hz), alpha (8-12 Hz) and beta wave (13-30 Hz). The analysis is carried out using Power Spectral density (PSD), Correlation co-efficient analysis. The outcome of this research depicted that high amplitude Alpha and low amplitude Beta wave and low amplitude Alpha and high amplitude Beta wave is associated with melody and rock music respectively meanwhile theta has no effect. High power of alpha waves and low power of beta waves that obtained during low levels of sound (Melody) indicate that subjects were in relaxed state. When subjects exposed to high level of sound (Rock), beta waves power increased indicating subjects in disturbed state. Meanwhile, the decrease of alpha wave magnitude showed that subjects in tense. Thus the subject's executional attention level is determined by analyzing the different components of EEG signal.


Role-based collaboration (RBC) is an emerging technology. Role-based approaches may significantly change and improve the infrastructure of management, organization, collaboration, and system development. This is the fourth year to organize a special session for RBC. The past special sessions were for IEEE International Conferences on Systems, Man and Cybernetics (SMC) (2003: Washington D.C., USA; 2004: The Netherlands; and 2005: Hawaii, USA). The successfulness encourages the continuing efforts. Role concepts have been applied widely in behavioral science, management, sociology, and psychology for many years. Roles are very useful in modeling the authority, responsibility, functions and interactions associated with manager positions within organizations.


We considered nutrition factor (nutrition structure, food safety in conjunction with working conditions and the actual nutrition of metallurgical workers – PJSC «Magnitogorsk Iron and Steel Works») and its place in the structure development of occupational morbidity of metallurgical workers. The irrational nature of workers' nutrition has been established with a predominant intake of saturated fats, sodium chloride, inadequate intake of a number of vitamins (A, D, folic acid) and bioelements (calcium). Hygienic recommendations on the correction of the nutritional structure depending on the identified deviations and its prevention measures are substantiated.


The $p$-adic Littlewood conjecture (PLC) states that $\liminf_{q\to\infty} q\cdot |q|_p \cdot ||qx|| = 0$ for every prime $p$ and every real $x$. Let $w_{CF}(x)$ be an infinite word composed of the continued fraction expansion of $x$ and let $\mathrm{T}$ be the standard left shift map. Assuming that $x$ is a counterexample to PLC we get several restrictions on limit elements of the sequence $\{\mathrm{T}^n w_{CF}(x)\}_{n\in\mathbb{N}}$. As a consequence we show that for any such limit element $w$ we must have $\lim_{n\to\infty} P(w,n) - n = \infty$ where $P(w,n)$ is a word complexity of $w$. We also show that $w$ can not be among a certain collection of recursively constructed words.


P leural ultrasound is a well-established modality for ruling out pneumothorax,1,2 including postbronchoscopy pneumothorax.3–5 Currently, some bronchoscopists use pleural ultrasound to assess for postbronchoscopy pneumothorax in lung transplant recipients, but the accuracy of this approach has not been well studied. One study demonstrated a pleural ultrasound examination 2 hours postbronchoscopy can rule out pneumothorax in lung transplant recipients; however, waiting 2 hours postbronchoscopy limits the practicality of implementing this study's approach.6 To determine whether an immediate postbronchoscopy pleural ultrasound examination can accurately rule out pneumothorax in lung transplant recipients in a clinical practice setting, we reviewed pleural ultrasound examinations of lung transplant recipients postbronchoscopy at our institution.


This work deals with exact soliton solutions of the nonlinear long-short wave interaction system, utilizing two analytical methods. The system of coupled long-short wave interaction equations is studied by two analytical methods, namely, the generalized tan ( ϕ/ 2)-expansion method and He's semi-inverse variational method, based upon the integration tools. Moreover, in this paper, we generalize two aforementioned methods which give new soliton wave solutions. Abundant exact traveling wave solutions including solitons, kink, periodic and rational solutions have been found. These solutions might play an important role in engineering and physics fields. By using these methods, exact solutions including the hyperbolic function solution, traveling wave solution, soliton solution, rational function solution, and periodic wave solution of this equation have been obtained. In addition, by using Matlab, some graphical simulations were done to see the behavior of these solutions.


The key processing for obtaining high quality investment casting of titanium alloys is of obtaining high quality ceramic shells. This paper is a research on properties of face coating materials, the materials employed include Y/Y, ZY/ZY and TJ/ZC. Properties of ceramic shells tested in this paper contain TG/DTA testing, strength testing and thermal expansion testing. The experiment demonstrates that TJ/ZC face coating material is an ideal face coating material for investment casting of titanium alloys.


A study on the effect of the substitution of fishmeal by Lima bean flour was conducted between March and May 2018 within the AIO ICG of the Batié District, with the global objective of contributing to the development of alternative sources of animal protein. Specifically, the aim of the study was to evaluate the effect of the substitution of fishmeal by Lima bean flour on the growth performance, survival and feed cost of Clarias gariepinus. For this purpose, 300 fry of Clarias gariepinus with an average weight of 3 ± 1.41g were divided into five batches and fed three times a day with rations corresponding to 5% of their ichthyo biomass. The rations R0, R25 R50, R75 and R100 respectively corresponded to the substitution rates of 0, 25, 50, 75 and 100% of fish meal by that of Lima bean. The physic-chemical characteristics of the water (pH, temperature, dissolved oxygen, nitrites and nitrates) were measured daily. The following results were obtained: The highest weight gains were obtained with the rations R25 (20.56 ± 0.40 g), R50 (20.64 ± 0.32 g), R75 (20.98 ± 0.46 g) and the lowest with the ration R100 (16.21 ± 0.28 g). For this average daily gain, the highest values were 0.36 ± 0.02 g; 0.37 ± 0.01 g, 0.38 ± 0.01 g respectively for the R0, R50 and R75 rations and the lowest with R100 (0.29 ± 0.01 g). The highest value of the specific growth rate (2.47 ± 0.07%) was obtained with the ration R0 and the lowest (1.61%) with the ration R100. The consumption index reached its highest and lowest values with the rations R100 (4.74 ± 0.42) and R50 (3.57 ± 0.43) respectively, compared to the value of the ration R0 (3.31 ± 0.37) for this parameter. Concerning the condition factor K, the highest value was recorded with the R50 diet (1.11 ± 0.49) while the lowest value was obtained with the R75 diet (0.95 ± 0.45). The cost of producing one kilogram of food was higher with the R25 ration (504.59 FCFA) and lower with the R100 ration (443.20 FCFA). This study found that incorporating 75% Lima bean flour into the feed increases the growth performance of Clarias gariepinus fry and reduces the cost of food production.


The present invention, pomegranate, phytoncide extract, ocher and pro liquid permeability of a composition comprising a material that is selected for more than three species from the group consisting of u extract disposable absorbent article the topsheet or the absorbent for the disposable absorbent article containing the functional substance by coating or immersion in the pad as well as to improve the feel and prevents skin problems, the present invention relates to a disposable absorbent article to enhance the antibacterial and deodorant effect. Disposable absorbent products, pomegranates, Phytoncide, ocher, propolis


According to the method of NY/T 148-1990,the goal of adding the activated charcoal is to reduce the color which leaching the soil' organic matter have some effection to phosphorus,but has limited the soil effective phosphorus batch determination.So we carried on the experiment under the no-activated charcoal condition to determine the soil effective phosphorus.The results indicated that,did not add the activated charcoal,the organic has nearly no effection to the determination of the phosphorus of soil;Two kinds of determination methods mean value in erroneous scope,but the improvement method is more approach to the NY/T 148-1990 standard value,measured the value separate leave lowly,stability strongly,also the determination speed quickly,the result high accurately,and the cost lowly.


In the present study an attempt is made to shed light on the problem of the role of one metalinguistic ability, namely, word-referent differentiation, in the development of conscious awareness in a child's thinking. Thus far, most investigations on the emergence and development of metalinguistic abilities in children are descriptive in nature, dealing with when and how these abilities emerge and develop. Few studies have been directly concerned with the problem of why a particular aspect of language is brought into consciousness whereas others are not [1]. One investigator who stresses the role of metalinguistic abilities in children's cognitive development is Donaldson [2], who suggests that the consequence of the development of metalinguistic abilities is the development of awareness in thinking.


The invention relates to drug application of a levo (R) salbutamol preparation in treatment of skin tissue injury, ulcer, suppuration, delayed union and other diseases caused by wound, bedsore, tumor, diabetes or concurrent infection and the like. The invention relates to application of levo (R) salbutamol medicated salt to preparation of preparations for skin mucosa surfaces. The invention also relates to combined preparations of levo (R) salbutamol with hormones, antibiotics and anti-inflammatory drugs.


Activating transcription factor 3 (ATF3) is a widely used marker of damaged primary sensory neurons that is induced in essentially all dorsal root ganglion (DRG) neurons by spinal nerve axotomy. Whether such injuries induce its expression in neurons of adjacent DRGs remains unknown. Following L5 spinal nerve ligation, experimental but not sham‐operated rats develop thermal and mechanical hypersensitivity. In the L4 DRG, 11–12% of neurons were ATF3 positive by 1 day post‐surgery, and numbers remain unchanged at 2 weeks. Importantly, sham exposure of the L5 spinal nerve produced a nearly identical number of ATF3‐positive neurons in the L4 DRG and also a substantial increase in the L5 DRG, with a similar time‐course to experimental animals. There was no correlation between behaviour and magnitude of ATF3 expression. Co‐localization studies with the DRG injury markers galanin, neuropeptide Y and nitric oxide synthase (NOS) showed that approximately 75, 50 and 25%, respectively, of L4 ATF3‐positive neurons co‐expressed these markers after L5 transection or sham surgery. Additionally, increases in galanin and NOS were seen in ATF3‐negative neurons in L4. Our results strongly suggest that the surgical exposure of spinal nerves induces ATF3 in the L4–5 DRG, irrespective of whether the L5 nerve is subsequently cut. This probably reflects minor damage to the neurons or their axons but nevertheless is sufficient to induce phenotypic plasticity. Caution is therefore warranted when interpreting the phenotypic plasticity of DRG neurons in adjacent ganglia in the absence of positive evidence that they are not damaged.


Patients with ulcer, hyperacid and normal acid gastritis were given nitrogen silicate mineral water from Annensk thermal springs. The water was found to inhibit acid-pepsin-forming function and to improve gastric motility and evacuation. Acceptable fluoride concentration and not a single case of the disease aggravation make the above mineral water suitable for rehabilitation of patients with ulcer and gastritis.


At present,prison remoulding work needs urgently a criminal judicature talents' team with high comprehensive quality and practical ability.It is the need of constructing modern civilized prison,of preventing crimes and maintaining social stability,of inproving our legal construction to foster professional talents through colleges,to develop criminal judicature undegraduate courses education and to foster overall ability talents of law enforcement management and education.


This community service is useful for helping residents of Kampung Bekelir who want to have additional income through a culinary business which is also an attraction in Tangerang City as well as in Kampung Bekelir which already has several culinary establishments that are already operating. This pecak lele training teaches the community in the process of making and can try it directly so as to produce a typical pecak lele creation that is different from the existing pecak lele. Counseling on how to make standard menus so as to help the community in making the pecak lele culinary business in Bekelir village. The community will also make healthy catfish halibut according to current trends with the addition of ginger and pure coconut milk in the manufacture.


The pharmacy profession has advanced remarkably, however, pharmacists have yet to obtain provider status at the federal level. Establishing pharmacists as providers is imperative in light of the growing shortage of primary care providers and need to provide care for medically underserved populations. Academic reform, professional development and legislation have all contributed to the furtherment of provider status. Yet, the cornerstone to obtaining this status lies in imminent changes at the health care and interprofessional collegial levels in conjunction with professional perseverance and legislative action. These actions will help ensure pharmacists as integral partners on collaborative health care teams in clinical service provision for managing patients' chronic conditions and medications, to ultimately, improve access to quality care and patient health outcomes.


SAN (Storage Area Network) is being widely used as enterprise data storage for its advantage. Currently, the main product of SAN includes FC SAN and IP SAN. Building the FC SAN is a very high cost project and there are also interoperability problems. IP is not very suit for transferring storage I/O data. To overcome the shortcoming, a VIA-SAN is designed by using VIA protocol replace the IP protocol. The experiment and analysis indicate that the VIA is more excellent than IP in data transfer.


In this thesis, luminescent Ru(II) complexes that contain a metal-based receptor site for nucleophilic small molecules were studied, with emphasis on their potential utility as luminescent chemosensors. Two approaches to achieving small-molecule dependent luminescence were investigated: one exploited a metal-based lumophore (Part 1) and the other an organic-based lumophore (Part 2). In Part 1 of this thesis, molecular sensors based on the well-known [cz.s-Ru(bpy)2(LL')] lumophore were investigated. Complexes in which L'-L' is a hemilabile phosphine-ether ligand (POR) were shown to bind small-molecule analytes (e.g., water, acetonitrile, thiols, dimethylsulfoxide) via displacement of the labile ether moiety, which was readily monitored 1 3 1 1 via H and P{ H} NMR spectroscopy. The resulting changes in the coordination sphere of the metal caused the metal-to-ligand charge-transfer derived absorption and emission spectra to be shifted. For example, complex 1, [c/s-Ru(bpy)2(POMe-.P,0)] (POMe = 2-methoxyphenyldiphenylphosphine), yields orange luminescence at low temperatures when the ether is metalbound. In response to analytes, the emission of 1 changes colour as follows: yellow for acetonitrile, cherry red for triethylamine, poppy red for dimethylsulfoxide, brownish yellow for thiols. Thus, [cz's-Ru(bpy)2(POR)] complexes are potential candidates for development into sensory materials in multianalyte sensor applications, although their luminescence is limited to low temperatures. A side reaction encountered during the preparation of 1 was also studied. Specifically, the metal-bound ether in 1 was found to be prone to dealkylation by free phosphine-ether ligands to form phosphino-phenoxide complex 4, [cz's-Ru(bpy)2(Ph2PPhO-P,0)]. Similar P,t9-complexes with the ligands POEt (POEt = 2-ethoxyphenyldiphenylphosphine) and PC20Me (2-methoxyethyldiphenylphosphine) showed lower propensities toward ether dealkylation. The trend in reactivity was determined to be related to the electrophilicity of the ether's C a as well as resonance stabilization of 4. Changes in the ether substituent in the P,0-ligands were found to influence the reactivity of the [cw-Ru(bpy)2(POR)] complexes. The POEt complex, 2, showed reactivity


Objective To investigate the analgesic effect of parecoxib sodium and oxycodone for postoperative pain after total knee arthroplasty. Methods Sixty patients undergoing elective TKA were randomly divided into 2 groups( n =30 each) : parecoxib group( group A),parecoxib and oxycodone group( group B). All the patients were received parecoxib sodium for analgesia at the first 24h after surgery. From then on,if the visual analogue score( VAS) 5 the supplements( parecoxib sodium,oxycodone) would be infused in turn till the patient felt comfortable or the analgesic effect reached the clinical maximum. The VAS and Ramsay sedation score( RSS) were recorded at 24,32, 40,48,and 72 hours after surgery. Adverse effects related to analgesia and the maximum tolerable degree of passive exercise were investigated and compared between the two groups. Results Compared with group A,the resting and exercising VAS was decreased in group B at 24,32,40,48,and 72 hours after surgery,while the sedation score increased( P 0. 05). And the maximum tolerable degree of passive exercise was higher in group B at the 48 and 72 hours after surgery( P 0. 05). No serious adverse effects occurred between the two groups. Conclusions Intravenous injection of parecoxib sodium combined with oral oxycodone is consistent trend of multimodal analgesia. It can realize the basic goal of postoperative analgesia in patients undergoing total knee arthroplasty.


Intelligent methodologies provide a good basis for multi-model simulation. Small, specialised systems have a large number of feasible solutions, but developing truly adaptive, and still understandable, systems for highly complex systems require domain expertise and more compact approaches at the basic level. The nonlinear scaling approach extends the application areas of linear methodologies to nonlinear modelling and reduces the need for decomposition with local models. Fuzzy set systems provide a good basis for understandable models for decomposed systems. Data-based methodologies are suitable for developing these adaptive applications via the following steps: variable analysis, linear models and intelligent extensions. Complex problems are solved level by level to keep the domain expertise as an essential part of the solution.


Abstract Using data developed for, and presented to, the US District Court, this study evaluates the performance of women-, African-American-, and Hispanic-owned firms vis-à-vis firms owned by neither women nor minorities in three different South Florida markets: architecture, structural engineering, and civil engineering. After controlling for the influence of experience, size, and location, three of the most commonly used determinants of firms' earnings, the empirical results suggest that the three markets do not convert firms' characteristics into economic outcomes in the same manner for women and Hispanic owners as for owners who are neither women nor minorities.


There is much hope and hype surrounding the development of innovative technologies, but are we as motivated and effective in assessing the potential risks of these technologies? It is prudent to assess and mitigate risks prior to deploying a new product or process, but how often is a risk assessment performed when new functionality or changes are proposed? This paper describes a rapid, Agile approach for intermittent risk assessment and surveillance when there are substantial changes to systems and their context of use. Fault Tree Analysis and Failure Mode and Effect Analysis were used as models in a customized approach to assess for risk and potential hazards of added functionality and changes to mobile products after initial deployment. We also describe benefits and challenges. A rapid risk assessment could also be used as an initial assessment in situations where the software development cycle is not amenable to a more time-consuming approach to risk assessment. A lesson learned in preparing to rapidly assess for risks is to consider several or some combination of approaches.


The assignment of industry type at a location generally influenced by, the amount of flagship industry and the factors number of potential infrastructure existed at a location. A kind of factors that affected to determination of flagship industry, observed in this research namely production, export, infestation, labour and location quotient. Complexity conditions of decision-making that focuses on the number of flagship industry, and every type of industry affected by the dominant factors that impact on a site, provide a model that unite a kind of its factors. This paper will be presented a model that focused to assign priority development of flagship industries in an area, respect to affected factors with analytic hierarchy process (AHP). The model consists of nine types of flagship industries which potentially to be developed, and affected by a potential factor consists on the flagship industry. Results of the study showed, in order to determine an important flagship industry developed in the future, depend on the availability of LQ index and production, which required to be able to follow the needs of the development of the dynamics of the market competition in the future for seaweed commodity.


Several titration algorithms can be used to adjust insulin dose and attain blood glucose targets. We compared clinical outcomes using three initiation and titration algorithms for insulin glargine in insulin‐naive patients with type 2 diabetes mellitus (T2DM); focusing on those receiving both metformin and sulfonylurea (SU) at baseline.


Emerging role of circular RNAs (circRNAs) in various biological processes have advanced our knowledge of transcriptional and post-transcriptional gene regulation. To date, no research has been conducted to explore their roles in the rice- Xanthomonas oryzae pv. oryzae (Xoo) interaction. Therefore, we identified 3517 circRNAs from the highly virulent Xoo strain PXO99A-infected rice leaves using the ribosomal RNA (rRNA) depleted RNA-sequencing technique coupled with the CIRI2 and CIRCexplorer2 pipeline. Characterization analyses showed that these circRNAs were distributed across the whole genome of rice, and most circRNAs arised from exons (85.13 %), ranged from 200 bp to 1000 bp and were with a non-canonical GT/AG (including CT/AC equivalent) splicing signal. Functional annotation and enrichment analysis of the host genes that produced the DEcircRNAs suggested that these identified circRNAs might play an important role in reprogramming rice responses to PXO99A invasion, mainly by mediating photorespiration, chloroplast, peroxisome and diterpenoid biosynthesis. Moreover, 31 differentially expressed circRNAs (DEcircRNAs) were predicted to act as miRNA decoys in rice. The expression profile of 4 DEcircRNAs were validated by RT-qPCR with divergent primers, and the back-splicing sites of seven DEcircRNAs were verified by PCR analysis and Sanger sequencing. Collectively, these results inferred a potential functional role of circRNAs in the regulation of rice immunity and provide novel clues for revealing the molecular mechanisms of rice-PXO99A interaction.


The article considers the intertextual relations of Thomas Bernhard's novel "Proofread» («Korrektur», 1975) and essayistic cycle of Paul Valerie "Mr. Test» («Monsieur Teste», 1896-1946). Quoting the name of the character of the famous French writer of essays, poetry anticipated the principles of modernism and postmodernism, Bernhard leads to complicated interpretation of the text. The article reveals the implicit connection of all creativity of Bernhard with the poetics and poetology of Valerie. This view elected in the domestic literature on Bernhard first. Particular attention is paid to the structure of the dissociated subject theme of duality, philosophy, writing, poetics of space. Familiarity with the full version of Bernhard "cycle test" Paul Valery argued pointing out the autobiographical text - "Three Days" by Bernhard (Drei Tage), where the Austrian writer calls the book of Valerie as the most important in his library, he returns to it again and again. General principles of poetics by Bernhard and Valerie - linguistic skepticism, literary composition and fragmentation pattern of the world, intellectualism, philosophy, self-reflexive writing. The protagonist of the novel "Proof" Roythamer and character of Paul Valery "Mr. Test" created by modernist scenario "man without qualities". This character-test, by which the authors examine the most controversial topics for them: the boundaries of language, plausibility, literary fame, psychology, finalism, self-identity of the character. Key words: Thomas Bernhard, Paul Valerie, intertextuality, linguistic skepticism, modernism, novel about the artist.