This work is about a project of institutional development, come back specifically
toward implantation of the Ambient Monitoring in Health (VAS) in the Natal city.
Breaking of the necessity of a structure in the sector health, in special in the Natal
city that answers to the problematic increasing constant and of the ambient
questions that influence in the health human being. In thi;context, the interference
in the health human being requires of the sector health, the estruturacao of services
that they contemplate a set of activities capable to know and to intervene in
opportune time, on conditionals determinative factors of the related process healthillness
to the environment, that they provoke changes in the morbid-mortality profile,
the short one, medium and long run. The methodology consisted of the happened
institutional document analysis of public institutions that had contributed to subsidize
the project of implantation of the VAS. This project is constituted by basic stages
that they contemplate: qualification technique; revision of the organization chart of
the Monitoring in Native Health/SMS; area organization estruturacao and intersetorial
joint effert that could be developed simultaneously or not. As end item change in the
profile of morbid-mortality for damage related to the natural environment, more
specifically expects, air, ground, water, accidents with dangerous products and
disasters.


The national program for the development of open-cycle MHD power generation is directed toward a demonstration of the commercial applicability of the technology by means of the operation of an Engineering Demonstration Plant on an electric utility line. In order to provide the engineering information necessary for the successful design, construction, and operation of the Engineering Demonstration Plant, components will be tested in an integrated system to obtain long-duration operation of an open-cycle MHD system using a Component Development Integration Facility (CDIF). Argonne National Laboratory (ANL) has responsibility to prepare a conceptual design of a coal-fired open-cycle MHD CDIF for siting at Butte, Montana. To assist ANL in the implementation of this effort, BCL has conducted a 3-month program to provide the conceptual design of the Instrumented Test Section (ITS) which will be used in the evaluation of the performance of selected 25 MW thermal coal-fired MHD combustors. Results of this study are presented.


An ASIC CMOS image Active Pixel Sensor (APS) with combined linear and logarithmic modes of operation is presented. The chip consists of a 64 x 64 pixel array, together with its digital control and timing circuits. Test structures including individual photodiodes and pixels are also integrated for characterization purpose. The chip features selectable linear and logarithmic modes of operation, digitally controlled integration time, and correlated double sampling (CDS) circuit for readout. The chip was designed and fabricated using a 0.6 μm CMOS process. The experimental results obtainedfrom the chip are presented in this paper.


well-established U37 0 based on long-chain unsaturated ketones synthesized by haptophyte algae and the newly proposed TEX86 derived from the membrane lipids of Crenarchaeota. Comparison of NIOP905 and 74KL core top data with present-day SST (0-10 m) values indicates that both proxies yield temperatures similar to local annual mean SSTs. However, TEX86 and U37 0 SST down-core records derived from the same cores differ in magnitude and phasing. The alkenone SST record of NIOP905 shows small changes in SST (� 0.5� C) over the last 23 kyr, while that of core 74KL shows a � 2� C increase from the Last Glacial Maximum (LGM) (23- 19 calendar (cal) kyr B.P.) through the Holocene (the last 11.5 cal kyr B.P.) synchronous with changes in the Northern Hemisphere. In contrast, the TEX86 records of both cores show a large increase in SST from 22� -23� C in the LGM to 28� -30� C during Termination I (19-11.5 cal kyr B.P.), decreasing to present-day annual means of � 26� C. A cold phase between 14.5 and 12 cal kyr B.P. that may correspond to the Antarctic cold reversal is also observed. This implies a Southern Hemisphere control on tropical SST reconstructed by the TEX86, possibly related to SW monsoon. Our results suggest that the application of both TEX86 and U37 0 give different but complementary information on SST developments in past marine environments.


In this paper the authors compare methods used for piezoresistive microcantilevers actuation for the atomic force microscopy (AFM) imaging in the dynamic shear force mode. The piezoresistive detection is an attractive technique comparing the optical beam detection of deflection. The principal advantage is that no external alignment of optical source and detector are needed. When the microcantilever is deflected, the stress is transferred into a change of resistivity of piezoresistors. The integration of piezoresistive read-out provides a promising solution in realizing a compact non-contact AFM. Resolution of piezoresistive read-out is limited by three main noise sources: Johnson, 1/f and thermomechanical noise. In the dynamic shear force mode measurement the method used for cantilever actuation will also affect the recorded noise in the piezoresistive detection circuit. This is the result of a crosstalk between an aluminium path (current loop used for actuation) and piezoresistors located near the base of the beam. In this paper authors described an elaborated in ITE (Institute of Electron Technology) technology of fabrication cantilevers with piezoresistive detection of deflection and compared efficiency of two methods used for cantilever actuation.


Unbalance voltage supply in induction motor is a crucial problem. This paper proposes an original system to detect an unbalance voltage condition in induction motor using Support Vector Machine (SVM). Induction motor current, as a signal due to the unbalance voltage supply in three-phase induction motor, is recorded in lab bench. The features of recorded signals are extracted by wavelet transform and Principal Component Analysis algorithm. Then, the quality of detection is classified by SVM, and the average result of detection is 86%.


The invention discloses a candle with a color flame and manufacturing method thereof. The candle with the color flame disclosed by the invention comprises a candle body and a candlewick, wherein the candle body contains a main burning agent, an optional high fatty acyl amide, an optional higher fatty acid triglyceride and an optional color former; the candlewick is treated by the color former and thereby contains the color former; the candlewick is longer than the candle body; and the part, which is extended out of the candle body, of the candlewick is impregnated with molten candle body mixture and thereby contains the candle body mixture. The candle with the color flame is easy to light; and after the candle is lighted, the flame is big and colorful, the candlewick does not separate (scatter) and is attractive, the color of the candlewick is consistent with that of the candle body, black smoke is not given off, and when stored, the candle does not go mouldy.


Fostemsavir, a prodrug of human immunodeficiency virus attachment inhibitor temsavir (TMR), is in phase III development in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type I (HIV‐1) infection in heavily treatment‐experienced adults with multidrug‐resistant HIV‐1 infection for whom it is otherwise not possible to construct a suppressive antiviral regimen due to resistance, intolerance, or safety considerations. The proarrhythmic potential of fostemsavir was studied in a thorough QT study and exposure–response modeling was performed at therapeutic and supratherapeutic concentrations of TMR. Fostemsavir 1,200 mg b.i.d. did not result in a clinically meaningful change from placebo in baseline‐adjusted Fridericia‐corrected QTc (ddQTcF); however, at a supratherapeutic dose of 2,400 mg b.i.d., the upper bound of the two‐sided 90% confidence interval (CI) of ddQTcF was 13.2 msec, exceeding the clinically important 10 msec threshold. A linear model of ddQTcF as a function of TMR plasma concentrations described these observations. Based on simulations with this model, TMR concentrations up to 7,500 ng/mL are expected to have an upper 90% CI bound for QTcF ≤ 10 msec. This concentration is 4.2‐fold higher than the geometric mean TMR peak plasma concentration (Cmax) of 1,770 ng/mL in heavily treatment‐experienced HIV‐1 infected patients administered fostemsavir 600 mg b.i.d. in the phase III BRIGHTE study (NCT02362503).


The purpose of this study was to propose repair techniques of Jungmyungjeon in Jeong-dong through analyzing on the buildings which are recently enforced. I am going to do the most suitable work through making the counterproposals to analyze facts and techniques in the process of construction.


The article is devoted to identifying the "weaknesses" of J. Chan's model of social cohesion theoretical conceptualization and empirical measurement and outlining promising areas for its adaptation to the Ukrainian context. It's summarized the necessity of refining the definition of social cohesion from the standpoint of social dynamics, supplementing the subjective component of the model with "value" indicators, diversification with projective issues in order to avoid the "spiral of silence" and Lapierre's paradox.


Root canal treatment is said to be completely successful when the tooth is restored and comes back to normal function. A more complex restoration is required after endodontic treatment when compared to normal tooth restoration, because of factors such as extensive caries, post-treatment root canal dentin and even the economics condition of the patient. With the availability of newer high strength materials like lithium disilicate dentists are now able to offer better esthetics and high strength restoration which withstands heavy occlusal forces with even thin layers. Thus, the aim of this case series is to summarize the recent advances of post endodontic restorations, various new materials their indications depending on the remaining tooth structure and the teeth that needs to be restored.


Hydrodynamics of plasma in the random magnetic field is considered, which is characterized by the second moment of magnetic induction. Equations of ideal magnetic hydrodynamics in such field are received for an adiabatic process. It is shown that in Euler Equation a new variable is second moment of magnetic induction enters, for which is received time Equation on the basis of Maxwell Equations in the magnetohydrodynamic approximation. The one dimension plane waves in this system are studied and the values of their phase velocities are received.


To extend the LHC physics program, it is foreseen to operate the LHC in the future with an unprecedented high luminosity. To maintain the experiment's physics potential in such harsh environment, the detector will need to be upgraded. At the same time the detector acceptance will be extended and new features such as a L1 track trigger will be implemented. Simulation studies evaluated the performance of the new, proposed detector components in comparison to the present detector with the expected aging after 1000 fb−1. The impact of the expected Phase II performance on representative physics channels is studied. The sensitivity to find new physics beyond the SM is significantly improved and will allow to extend the SUSY reach, search for dark matter and exotic long-lived signatures. Precision Higgs and standard model measurements will gain substantially due to the improved performance.


Summary During the water‑soaking process to remove arsenic from dried Hijiki at 30℃ some other beneficial elements are also lost. During this process the amounts of calcium iron magnesium and zinc released into water were 49 % 32 % 77 % and 70 % of those originally present respectively. Thus water‑soaking for longer than 30 min at room temperature is recommended to eliminate arsenic from Hijiki but it should be cooked together with other materials such as soybeans carrot etc to supply the lost beneficial elements.


Some basic concepts of the interval-valued propositional logic system are introduced.The probability measure and the probability space are expanded to the interval-valued.On this basis,the finite interval-valued measure is defined,and the concept of the infinite product is given on the interval-valued probability space.The concept of the ā-truth degrees is introduced in the Lukasiewicz interval-valued propositional logic system,interval-valued truth degree reasoning rules are discussed,and its properties are proved.


An international workshop on the theme 'From Bench to Bedside: Translational Neuroscience Research in Healthy Brain Aging and Neurological Disorders' was held at the University of Sri Jayewardenepura (USJP) from December 14-20, 2015, with the participation of Honorable Minister of Nutrition and Indigenous Medicine, Dr. Rajitha Senaratne and Honorable Minister of Primary Industries, Daya Gamage (fig. (fig.1,1, ,2).2). About 32 faculty of internationally acclaimed academic repute and clinicians representing renowned institutions of higher learning participated from Australia (3), China (11), India (8) (Centre for DNA Fingerprinting and Diagnostics-2, Centre for Neuroscience, Indian Institute of Science-1, CSIR-Institute of Genomics and Integrative Biology-1, Jagadguru Sri Shivarathreeswara University-1, National Institute of Mental Health and Neuro Sciences-1, Panjab University-1, Post Graduate Institute of Medical Education and Research-1), Japan (1), Malaysia (2), Netherlands (1), Singapore (1), Thailand (1), UK (1), USA (3) and participants for the workshop included 11 international faculty from Asia Pacific Region (China (1), India (4), Iran (3), Nepal (1), Pakistan (1), Thailand (1)) while 35 participants were there from Sri Lanka. The aim of the meeting was to support a transition of the current research culture in the region from descriptive to innovative multidisciplinary research by providing exposure to cutting edge technology. This workshop was a joint venture with the International Brain Research Organization (IBRO) through the Asia Pacific Regional Committee (APRC). Participants of the workshop included graduates, postgraduates, scientists, academics and industrialists (fig. (fig.3).3). Lectures covered 5 main areas (molecular diagnostics of neurodegenerative, neuromuscular diseases and stroke, neuropathology, proteomics, cell culture techniques, mind relaxation and natural products in healthy brain aging) and hands-on training in proteomics, nanotechnology, cell culture techniques and molecular genetics including PCR, RT-PCR, TP-PCR, MLPA, mass spectrometry, brain cancer and ayurgenomics related information. Five symposia were organized with over 100 participants: (a) symposium on the use of natural products unique to Sri Lanka to foster healthy brain aging to bridge industry and academia in private-public partnerships through medicinal plants unique to Sri Lanka, (b) symposium on Parkinson's disease and movement disorders by the International Parkinson's and Movement Disorders Society to bridge the gap between neuroscientists and clinicians, (c) symposium by the European Graduate School of Neuroscience (EURON) to facilitate double doctorate opportunities in neuroscience between EURON and USJP, (d) symposium by the Chinese Neuroscience Society, being the first joint symposium between China and Sri Lanka and (e) symposium on mindfulness and mind relaxation in healthy brain aging.


An anthology of critical commentaries selected from the classical period to the late modern. It explores some of the central and emerging themes, issues and debates within Art History as an increasingly expansive and globalised discipline. It features an international range of contributors , including art historians, artists, curators and gallerists.


Flow-based video frame interpolation approaches typically adopt forward or backward warping to approximate the intermediate frames. And a synthesis network is used to refine the interpolation results. Optical flows indicate motion between two input frames, but both forward and backward warping only utilize the first frame. In this work, we propose bilateral warping to make full use of optical flows. Specifically, the proposed bilateral warping yields intermediate candidates from not only the first frame but also the second frame. Our model first applies bilateral warping on the input frames and contextual features. Then, we add skip connections from the input frames and contextual features to the synthesis network. Finally, the synthesis network generates the interpolation results by integrating the original and warped representations. The experimental results on a wide variety of datasets demonstrate the superiority of the proposed approach over the state-of-the-art video frame interpolation methods.


This paper presents a simple and nonintrusive method to identify and compensate for current measurement errors in interior permanent magnet synchronous motor (IPMSM) drives. Each IPMSM has a distinct steady-state short-circuit current characteristic. By controlling the motor to operate at its steady-state short-circuit current during coasting down, the inverter can be used to smoothly switch the IPMSM into three-phase short-circuit state. Then the d-q axis measured currents are compared with the true short-circuit characteristic of the IPMSM. The distortion pattern in the d-q axis currents contains all the needed information to correct for current sensor errors in IPMSM drives. For a three-phase motor, the proposed method can correct for single-current-sensor error or dual-current-sensor error with good accuracy. The effectiveness of the method is validated by both simulation and experiment.


Calcium phosphates are the main mineral component of vertebrate bones and teeth. Studying calcium phosphate nucleation can improve our understanding of physiological and pathological biomineralization events, and could therefore assist the design of superior biomaterials, e.g., in bone repair applications. It has been suggested that calcium phosphate crystallization proceeds along non-classical crystallization pathways [1]. The latter assume that free ions in solution are in equilibrium with larger solute species dubbed prenucleation species (PNS). These clusters tend to aggregate with time, leading to the nucleation of an amorphous phase that later transforms into a crystalline phase, such as hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) in case of bone mineralization [2]. However, little is known about PNS because of their nanometric size, their highly dynamic behavior and their short life-time [3]. In this work, we use both, liquid and solid-state NMR, in a time-resolved manner to highlight dynamics (PNS formation and aggregation rate, phosphate chemical exchange) and structural (size, chemical composition) details regarding PNS. We demonstrate that in SBF (simulated body fluid, a (meta)stable solution that mimics human blood plasma) free phosphates reach a full conversion into PNS after >15 hours, questioning the "stability" of SBF. 31 P diffusion ordered spectroscopy (DOSY) experiments and cryo-TEM observations revealed species of 2 nm in size that tends to aggregate into supramolecular structure of several hundreds of nm. Furthermore, we show through calcium ion and pH potentiometry that prenucleation clusters display a chemical composition close to calcium triphosphate units. We also performed 31 P MAS DNP


Local magnetic properties around a nonmagnetic impurity are investigated in high-Tc cuprate superconductors. We consider a model two-dimensional dx2−y2-wave superconductor with strong antiferromagnetic (AF) spin fluctuations and calculate the spin susceptibility around the impurity. We show that the uniform susceptibility (χ(0)), which is usually suppressed in spin-singlet superconductivity, is enhanced at low temperatures around the impurity when the impurity scattering is in the unitarity limit. This anomalous behavior is more remarkable when the impurity potential is extended spatially and the AF spin fluctuations are stronger. As the origin of this phenomenon, we point out the importance of (1) a low-energy bound state around the impurity and (2) a mode-mode coupling effect which connects the AF spin fluctuations with χ(0). Our results can explain the anomalous temperature dependence of the Knight shift on Li which was recently observed in YBa2(Cu1−xLix)3O6+y. Typeset using REVTEX 1


CACI has developed and delivered systems for document exploitation and processing to Government customers around the world. Many of these systems include advanced language processing capabilities in order to enable rapid triage of vast collections of foreign language documents, separating the content that requires immediate human attention from the less immediately pressing material. AppTek provides key patent-pending Machine Translation technology for this critical process, rendering material in Arabic, Farsi and other languages into an English rendition that enables both further automated processing and rapid review by monolingual analysts, to identify the documents that require immediate linguist attention. Both CACI and AppTek have been working with customers to develop capabilities that enable them, the users, to be the ones in command of making their systems learn and continuously improve. We will describe how we put this critical user requirement into the systems and the key role that the user's involvement played in this. We will also discuss some of the key components of the system and what the customer-centric evolution of the system will be, including our document translation workflow, the machine translation technology within it, and our approaches to supporting the technology and sustaining its success designed around adapting to user needs.


Computer modelling of the acoustic characteristics of signals of direct normal probe with phased array (PFR) in the cast iron with flake and globular graphite was performed. As a result the form of acoustic pulses of a longitudinal wave, depending on the passed by wave distance and the values of attenuation coefficient for different models of cast iron was calculated. The main modeled characteristics of the probe include the directivity characteristic and the change in the amplitude of the signal along the acoustic axis. It is shown that the difference in the PFR directivity characteristics for cast iron with flake graphite of different models and steel is due to two factors – significantly lower longitudinal wave velocities in cast iron compared to steel and a decrease in its operating frequency due to attenuation. In this case, for cast iron with globular graphite, a small change in the width of the diagrams is due only to the lower speed of longitudinal waves in cast iron compared to steel. For cast iron with flake graphite model 3, the phenomenon of nonlinear attenuation due to a decrease in the frequency of the maximum of the signal spectrum during the propagation of a longitudinal wave in cast iron with a corresponding decrease in the frequency – dependent attenuation coefficient is established. Evaluation of the nonlinearity of attenuation for cast iron with globular graphite showed that it is very small. The influence of calculation of initial signal delays on the velocity of longitudinal waves in steel on the directivity characteristics in cast iron, decreasing with increasing focus distance, is established. It is shown that for cast iron with flake graphite there are cases when the direction of transmitting of PFR in cast iron is practically absent.


In this paper we prove two asymptotic estimates for pairs of closed trajectories for open billiards similar to those established by Pollicott and Sharp (2006 Invent. Math. 163 10–24) for closed geodesics on negatively curved compact surfaces. The first of these estimates holds for general open billiards in any dimension. The more intricate second estimate is established for open billiards satisfying the so-called Dolgopyat type estimates. This class of billiards includes all open billiards in the plane and open billiards in (N ⩾ 3) satisfying some additional conditions.


The limited scope for extending the frontiers of demographic research is noted by the author who suggests some new perspectives on previous research in light of Indias specific needs as a developing country. (ANNOTATION)


The attosecond streaking technique is used for the characterization of isolated extreme ultraviolet (XUV) attosecond pulses. This type of measurement suffers from low photoelectron counts in the streaked spectrogram, and is thus susceptible to shot noise. For the retrieval of few- or mono-cycle attosecond pulses, high-intensity streaking laser fields are required, which cause the energy spectrum of above-threshold ionized (ATI) electrons to overlap with that of the streaked photoelectrons. It is found by using the principal component generalized projections algorithm that the XUV attosecond pulse can accurately be retrieved for simulated and experimental spectrograms with a peak value of 50 or more photoelectron counts. Also, the minimum streaking intensity is found to be more than 50 times smaller than that required by the classical streaking camera for retrieval of pulses with a spectral bandwidth supporting 90 as transform-limited pulse durations. Furthermore, spatial variation of the streaking laser intensity, collection angle of streaked electrons and time delay jitter between the XUV pulse and streaking field can degrade the quality of the streaked spectrogram. We find that even when the XUV and streaking laser focal spots are comparable in size, the streaking electrons are collected from a 4π solid angle, or the delay fluctuates by more than the attosecond pulse duration, the attosecond pulses can still be accurately retrieved. In order to explain the insusceptibility of the streaked spectrogram to these factors, the linearity of the streaked spectrogram with respect to the streaking field is derived under the saddle point approximation.


A development in laboratory bench-testing facilities for protective schemes is described. Test benches used at present contain linear inductors which have high X/R ratios so that offset transients associated with power systems may be simulated. However, owing to losses in the test network, these transients cannot be satisfactorily reproduced at large currents. It is shown here that by replacing the make switch in the conventional test bench with two inverse-parallel-connected thyristors, fired at carefully chosen intervals, it is possible to simulate transients on any system with acceptable accuracy. Details of the proposed test circuits are given, and both computed and experimentally obtained results are included to illustrate the negligible nature of the errors introduced. A method using the equipment for fusegear testing is also described.


This article analyzes the behavior of gender indicators on the economic, physical, and decision-making autonomy of Latin-American women, based on data compiled and published in 2020 by the Gender Equality Observatory of the United Nations Economic Commission for Latin America and the Caribbean (ECLAC), for 17 countries. Using the HJ-Biplot multivariate technique, it is concluded that the three evaluated areas interact with each other, in such a way that they cannot be interpreted in isolation because their relationships and interdependencies explain the differences in the participation of men and women in the socioeconomic and political environment of the nations in the region. Additionally, it is concluded that in countries such as Guatemala, Honduras, El Salvador, Bolivia, and Ecuador, greater public policy actions are required to seek the economic empowerment of women; while in Brazil, Mexico, and Colombia, laws are necessary to regulate violence against women. It is necessary to continue promoting gender equality in the region as a determinant factor in methodological frameworks and transformational policies to enable moving towards the construction of sustainable societies and economies.


The system is researched and developed in combination with the current development of computer technology, to meet the demands of the medium and small-sized enterprises for informatization of internal management. The system is constructed by use of JavaBean technology for JSP dynamic webpage making. It is designed in B/S development model, and adopts Tomcat as JSP server, and MyEclipse as the development environment, while DB 8.2 is used for the backend database. The major part of the system is constructed in the structure of customer end—middle layer (module layer) ---data base. The system administrator can increase, delete, revise and query the information, while the common users cannot take information retrieval. It has been proved by practice that the system developed corresponds to the demands of the enterprises for internal management and has a great application prospect.


Presentation on the 4th European Content Manager (Digital Library) Forum Workshop in Essen, 05.-06.09.2002. Some remarks on managing digital information objects in co-operative networks for academic e-publishing, like Hamburg University Press, German Academic Publishers (GAP) project and the European Figaro project.


A brilliant scholar, the librarian at one of England's most venerated cathedral libraries, once confessed to me that he had at times been his own charwoman and scrubbed the ancient floors. Such extension of accomplishment may seem somewhat incongruous. Yet is it so foreign to our own experience? What librarian has not dusted and mended and plated the good, bad, and indifferent among his voluminous possessions? Which of us has not left important duties to reveal the sequence of the alphabet to bewildered patrons struggling with the encyclopaedia or handbook of manufactures?


Purpose: Radiofrequency ablation (RFA) has been shown to elicit tumor-specific T-cell immune responses, but is not sufficient to prevent cancer progression. Here, we investigated immune-suppressive mechanisms limiting the efficacy of RFA. Experimental Design: We performed a retrospective case-controlled study on patients with synchronous colorectal cancer liver metastases who had received primary tumor resection with or without preoperative RFA for liver metastases. Tumor-infiltrating T cells and tumoral PD-L1 expression in human colorectal cancer tissues were analyzed by immunohistochemistry. T-cell immune responses and PD-1/PD-L1 expression were also characterized in an RFA mouse model. In addition, the combined effect of RAF and PD-1 blockade was evaluated in the mouse RFA model. Results: We found that RFA treatment of liver metastases increased not only T-cell infiltration, but also PD-L1 expression in primary human colorectal tumors. Using mouse tumor models, we demonstrated that RFA treatment of one tumor initially enhanced a strong T-cell–mediated immune response in tumor. Nevertheless, tumor quickly overcame the immune responses by inhibiting the function of CD8+ and CD4+ T cells, driving a shift to higher regulatory T-cell to Teff ratio, and upregulating PD-L1/PD-1 expression. Furthermore, we established that the combined therapy of RFA and anti–PD-1 antibodies significantly enhanced T-cell immune responses, resulting in stronger antitumor immunity and prolonged survival. Conclusions: The PD-L1–PD-1 axis plays a critical role in dampening RFA-induced antitumor immune responses, and this study provides a strong rationale for combining RFA and the PD-L1/PD-1 blockade in the clinical setting. Clin Cancer Res; 22(5); 1173–84. ©2016 AACR.


Ultrasonic velocity measurements have been made to obtain the dynamic elastic stiffnesses necessary to determine fully the elastic properties of a unidirectional glass‐reinforced epoxy‐fiber composite. In units of 106 psi, these stiffnesses are C11=6.01, C22=C33=2.58, C12=C13=0.70, C23=1.42, and C44=0.49, where the subscript 1 refers to the fiber direction. Since more velocities were measured than were necessary to obtain the five constants required by the symmetry of this composite, the extra measurements were used to check on the experimental method. Analysis shows the ultrasonic technique to be satisfactory for measurement of the elastic stiffnesses of a fiber composite. The experimental results are compared with the elastic constants predicted for this composite from expressions based upon several theoretical models. Good agreement is obtained when the theoretical calculations are made using the dynamic (as opposed to the static) modulus of the epoxy matrix.


The present invention relates to a novel method of copolymerizing ethylene copolymer product having improved properties such as higher crystallization start temperature. Preferably, the method comprises a first ethylene / α- olefin copolymer has a very high comonomer content and relatively high molecular weight along with having a narrow molecular weight distribution (NMWD) In the second ethylene / α- olefin copolymer is low comonomer the content of the air and the first molecular weight or more lower molecular weight and by using a catalyst of two or more species restricted geometry having different reactivity, which have a NMWD first ethylene / α- olefin with the homogeneous copolymer and one or homogeneous copolymer of claim 2 involves the copolymerization of ethylene / α- olefin copolymer. A first homogeneous copolymer produced with a second homogeneous copolymer produced makes the final polymer structure that combines a ratio appropriate Jungnang purpose. Or it may be polymerized a first copolymer and the second copolymer in a single reactor, or the polymerization may be those in the individual reactors operating in parallel or in series.


Magnolosides B and C. new phynylpropanoid glycosides have been isolated from the MeOH extract of (Magnolia)___- (obovata)___- Thunb. on the basis of spectroscopic data and chemical evidence. their structures have been established respectively as 3, 4-dihydroxy-β-phenyl-ethyl-o-α-L-rhamnopyranosyl-(1→2)-o-β-D-glucopyranosyl-(1→6)-3-O-caffeoyl-β-D-allopyranoside and 3, 4-dihydroxy-β-phynyl-ethyl-O-α-L-rhamnopyranosyl-(1→2)-O-[O-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1→6)]-3-O-cayyeoyl-β-D-allopyranoside.


When dealing with chronic pain, it is often not possible for clinicians to provide adequate answers to their patients about what might be wrong, and why they continue to have their pain. This has led to greater use of diagnostic "labels" for conditions such as fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, chronic Lyme disease, and many others. Assigning such "labels" to patients with chronic pain has far-reaching consequences for all stakeholders. The aim of this clinical commentary is to highlight some of the common threads among 4 particular conditions common to women—fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and chronic Lyme disease—when it comes to the underlying neurobiology and its consequences for the patient and treating clinicians. By taking a "big picture" view of pain as a multiple system output activated in response to threat, we discuss how the various output systems activated can lead to clusters of symptoms that may predispose patients to one or other of these 4 diagnostic conditions. There is now emerging evidence that during the biological response to threat, one output system may be more affected than the others and dominate the clinical picture, hence manifesting as a particular diagnostic condition. We propose that ultimately, these conditions essentially mean the same thing, that the patient has chronic pain, and we advocate for treatment of the patient, not the condition. The ability to look beyond the "label" and seeing the person in front of you is imperative when it comes to providing hope.


BACKGROUND: WBC reduction of blood components by filtration is widely practiced to decrease the incidence of alloimmunization. Freezing RBCs reduces the WBC load but is insufficient to achieve the currently recommended US limit of 5 × 106 cells per unit.


The choice of chromosome representation in genetic algorithms depends on the variables of the optimization problem being solved. If the variables are realvalued, the chromosomes can be represented as fixed-point integer values which enables the use of classical genetic operators defined for binary strings. Another possible chromosome representation is using floating-point numbers directly. In this case, genetic operators have to be defined additionaly. This paper presents a different approach: floating-point chromosome representation with traditional genetic operators. In order to achieve fine local tuning of the solutions, a mapping is defined which dynamically changes the operating scope of genetic operators.


IP trace back technique is an effective method to find either the attack origin or command-and-control (C&C) server on the Internet. The traditional ACO (ant colony optimization) constantly converged to a local minimum solution easily such that the global most portable of the final solution might be missed. Accordingly, the present study proposes a modified ACS (ant colony system) scheme designated as ACS-IPTBK to solve the IP trace back problem, predict both the most probable attack path and the computational resources needed in botnets. The ability of the ants to search all feasible attack paths is enhanced by means of a global heuristics. A series of ns2 simulations are performed to investigate the minimum resources required to successfully reconstruct the attack path. The convergence time for attack paths of different routing distances were investigated using a random graph generator based on Waxman's scheme. Overall, the results confirm that the proposed method provides an effective means of reconstructing the path between the attacker and the victim based on the incomplete routing information from the related ISPs.


Indian economy is witnessing an accelerating growth over a period of time. Success of high growth rate is attributable to rise in manufacturing industries, service sector industries and exports. However, for India to perpetually grow with a precedent rate and surpass its competitors like China considerable attention is required towards building large amount of capital, efficient utilisation of resources, increase in factor productivity, creation of more employment and most importantly building human resources(Bosworth, Collins, & Virmani, 2007).No nation can attain full economic and social development unless it recognises, taps and efficiently utilises its human resources. Human capital is a critical resource for the economic success of a nation and women comprises of half of that critical resource(Jackson, 2009).


Cloud computing is an Internet-based computing solution which provides the resources in an effective manner. A very serious issue in cloud computing is security which is a major obstacle for the adoption of cloud. The most important threats of cloud computing are identified and understood in this survey. This paper covers the information about the threats such as- Multitenancy, Availability, Loss of control, Loss of Data, outside attacks, DOS attacks, malicious insiders, etc. The solutions to overcome some of these threats have also been highlighted in this paper.


In response to the growing demand for X‐ray research, and to satisfy future needs for generating circularly polarized synchrotron radiation in the X‐ray region, a 3.5 T superconducting multipole with a periodic length of 6 cm was designed to produce horizontal linearly polarized, and circularly polarized light on a 1.5 GeV electron storage ring. Differently arranged excitation current loop for the same coil design switched between the operation of symmetric and asymmetric modes to creat the linearly and circularly polarized light, respectively. This study elucidates the design concepts of the superconducting multipole wiggler with symmetric and asymmetric operation modes. The design of the magnetic circuit and the field calculation are also discussed. Meanwhile, the spectra characteristics of the symmetric and asymmetric modes are calculated and presented in this article.


The aim of this study was to investigate the effects of maternal caffeine intake during pregnancy and lactation on the skin of rats and their offspring, as well as their relationship to maternal serum levels of cortisol. 24 adult Wistar rats were equally divided into four groups represented by the control and treated with caffeine at doses of 25, 50 and 100mg/kg. The groups received caffeine by orogastric tube during the entire pregnancy and lactation. The control received distilled water as placebo. Different types of hair follicles and the thickness of the epidermis were assessed and quantified. Immunohystochemistry technique using antibody anti-CDC47 was used to evaluate cellular proliferation of the epidermis and hair follicles of the mothers. Also in the mothers, serum levels of cortisol were measured by the chemiluminescence technique. Data were submitted to analysis of variance comparing mediums by Kruskall Wallis Test and SNK. In groups treated with caffeine 25 and 50mg/kg, both mothers and their Recebido em 20 de agosto de 2013 Aceito em 13 de março de 2015 *Autor para correspondência (corresponding author) E-mail: email@example.com


PROBLEM: Female sex hormones modulate a variety of humoral and cell‐mediated immunologic functions. In this study, the effects of estrogen, progesterone, and testosterone on the chemiluminescence (CL) response and phagocytic ability of male rat peritoneal macrophages (Mφ) were examined.


The European energy system is increasing its renewable share, primarily that of wind and solar photovoltaic energy. Going forward, the system will need better interconnections and storage integration to balance the mismatch between electricity demand and renewable generation. Europe has already a large capacity of pumped-hydro storage installed. Moreover, Li-Ion batteries are emerging as a promising cost-e ff ective storage option. Taking that into consideration, we analyze to which extent a highly renewable system benefits from an additional storage technology, named storage-X, in addition to pumped-hydro storage and batteries. In our analysis, we identify which characteristics of storage-X are required for it to play a prominent role in the system. For the study, we use an overnight capacity and dispatch-optimization model of a future decarbonized sector-coupled European energy system. In total, the system is optimized for 2,016 configurations of storage-X characteristics, including e ffi ciency and cost properties, to define the space of feasible configurations. By comparing this space with the characteristics of storage technologies currently under development (e.g., pumped thermal energy storage, compressed air energy storage, etc.), we learn that significant improvements are needed for them to become part of the optimal solutions. Reducing energy capacity cost, increasing discharge e ffi ciency, and reducing the cost of charging power capacity must be prioritized. As other sectors are electrified, the design space for storage-X shows similar characteristics. We find a potential system cost reduction of 10% with the best storage configuration. But for this to be realized, the storage is required to provide a high load coverage. Even in that case, renewable curtailment of 1% is still present in the optimal system.


An analysis based on the wavelet transform has been performed in order to identify families in the proper elements space of asteroids. This multi-scale analysis has been made on a set of 4100 proper element computed by a new second order fourth-degree secular perturbation theory (Milani and Kneževic, 1990, Cel. Mec., 4). A metric has been defined in the proper element space in order to give a dynamical definition of families. This metric is related to the incremental velocity needed for orbital change after the ejection from a fragmented parent body


Description Prevention of compulsive cocaine taking Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulnerability to drug addiction. However, the relevant circuits and underlying cellular processes remain elusive. Li et al. discovered a synaptic mechanism in mice that underlies the modulatory role of 5-HT in reducing the likelihood of transition to compulsion and eventually addiction (see the Perspective by Miyazaki and Miyazaki). Cocaine binds to 5-HT transporters to block 5-HT reuptake. The elevated extracellular 5-HT activates 5-HT1B receptors and causes presynaptic depression of a projection from the orbitofrontal cortex to the dorsal striatum. These changes reduce the likelihood of inducing postsynaptic potentiation at these synapses, which ultimately drives compulsion. —PRS Serotonin can prevent the development of compulsive cocaine seeking in mice. Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also boost extracellular serotonin (5-HT) by inhibiting reuptake. We used SERT Met172 knockin (SertKI) mice carrying a transporter that no longer binds cocaine to abolish 5-HT transients during drug self-administration. SertKI mice showed an enhanced transition to compulsion. Conversely, pharmacologically elevating 5-HT reversed the inherently high rate of compulsion transition with optogenetic dopamine self-stimulation. The bidirectional effect on behavior is explained by presynaptic depression of orbitofrontal cortex–to–dorsal striatum synapses induced by 5-HT via 5-HT1B receptors. Consequently, in projection-specific 5-HT1B receptor knockout mice, the fraction of individuals compulsively self-administering cocaine was elevated.


Photo shows three putti : a cook with a pot smoking hot from the fire; a chemist with a blowpipe; and a little Mars, polishing a helmet. (Source: Cole and Reed, Library of Congress, 1997)


Formation control strategies are fundamentally impacted by the sensing modalities present in the multi-robot team. Infinitesimal shape-similarity describes frameworks for which maintaining the relative angles between robots in formation also maintains the shape up to translation, rotation, and uniform scaling; however, ensuring invariance of the formation to these motions requires that the robots measure a sufficient number of angles, which means that the topology of the frame-work must be carefully designed. In this paper, we investigate the self-assembly of a class of infinitesimally shape-similar frameworks by robots equipped with bearing-only sensors. To accomplish self-assembly, we introduce a rank condition on the shape-similarity matrix for analyzing frameworks; we then use this rank condition to show that triangulations are infinitesimally shape-similar. A graph grammar is presented to assemble triangulations, and a controller is designed to achieve self-assembly of a team of differential-drive robots.


Present work reports the green synthesis of highly stable, non-toxic, environmental friendly, fluorescent carbon quantum dots (CQD) via simple synthetic route using the waste carbon paper as their precursor. The as-synthesized CQD were post-synthetically modified with (3-Aminopropyl)triethoxysilane (APTES) as a nitrogen source for amine functionalized CQD (NCQD) formation. When excited at wavelength λex = 350 nm, the maximum emission intensity of NCQD was observed at wavelength λem = 450 nm. The QDs show blue colored luminescence with significant photoluminescence quantum yield (∼5.1%). Transmission electron microscopy and Energy-dispersive x-ray spectroscopy data show their size about 4.8 nm and the presence of nitrogen in elemental composition respectively. XRD and selected area electron diffraction patterns reveal their amorphous nature. This NCQD based sensing probe selectivity displays the high sensitivity for trinitrotoluene (TNT) in 4.4 nM to the 26.4 μM range. The probe delivers a 7.4ppb detection limit at 1.3% relative standard deviation.


Because retail sales taxes generate substantial revenue for many local governments, public officials contemplating differential local option tax rates must carefully assess the potential impacts of such decisions on purchasing decisions. The authors use a unique pooled time series to examine these impacts and apply a methodology that permits an analysis of the effects on purchasing decisions of sales tax rate differences across numerous consumer goods. The results indicate that the response to sales tax rate differences depends on the general characteristics of the goods being purchased. A unique variable that controls for the distance to the next significant alternative for making a purchase also provides key insights. The observed significance for this variable and its interaction with tax rates has significant public policy implications.


Otherwise: A sort of introduction. 1. Imaginary Worlds 2. Popular culture and the internal other 3. The monstrous human races 4. The monstrous human races of America 5. A monstrous idiom: articulation 6. A monstrous idiom: punctuation 7. Eurocentrism and Ethnocentrism 8. The elementary structures of alterity.


: Portunids are decapod crustaceans of high economic importance. Seasonal variation in macronutrient and micronutrients contents of Callinectes amnicola from three interconnecting lagoons were investigated using standard methods. The percentages of protein and moisture contents in the flesh were higher than that of the shell, while higher ash and nitrogen free extract were obtained in the shell. Crude fibres was not detected in flesh of C. amnicola but detected in shells with values ranging from 0.30 ±0.72 % ( C. amnicola from Lagos Lagoon) to 0.55 ±2.15 % ( C. amnicola from Badagry Lagoon). There were statistical differences (P ˂ 0.05) in crude fibre and carbohydrate levels of the crab shell during wet and dry seasons while significant difference exist in protein level only in wet season. Protein showed negative correlations with all the minerals in crabs from Badagry and Epe Lagoons but positive correlation with all examined minerals in Lagos Lagoon crabs. The study demonstrated that Callinectes amnicola is rich in macro-micronutrients and characterized by low lipid content (< 3%). The nutrient biochemical constituents in the crab species vary with season.


This paper used the cointegration method and the stochastic frontier production function to measure industrial capacity utilization of China's 30 provinces in 2001—2011,and empirically decomposed the effects of different factors on the capacity utilization.The study found as follows.First,the two methods of the regional industrial capacity utilization are basically identical.Second,the change of capacity utilization shows obvious economic cycle characteristics.Third,the capacity utilization of the eastern region is lower than the central and western regions.Fourth,China's risk of excess capacity is spreading from the local to the country.After examining regional inventory as well as economic benefit index,30 provinces could be divided into three types which are certainty excess,possibility excess and underlying excess risk.


Automatic Image Annotation (AIA) is an eective technology to improve the performance of images retrieval from large image collections by text queries. In this paper, we propose a novel AIA scheme based on nding the most similar images using a distance metric and then transferring the annotation to the query image. The proposed method can eectively deal with the problem of nding the resulting annotation length. We propose an iterative renement optimization algorithm to nd the best parameters for the annotator. We evaluate the proposed method on two similarity criteria, Minkowski distance and Jensen-Shannon divergence. The proposed solution outperforms the current state-of-the-art methods and could be treated as a new baseline for other automatic image annotation methods.


The paper situation,fund paper amount,author professional title and school background of Journal Zhengzhou Institute Aeronautical Industury Manegement(Socical Science Edition) are counted on the basis of academic papers published on the during 2005~2008.The results show that economic and management paper,teaching paper are the most.Except the art and other column,history and philosophy paper were the least;fund paper increasing each year;post-graduate writers and intermediate title writers were the core author group.At last the reasons resulted in the state are analyzed and countermeasures are proposed.


The rigorous version of the result that unifies Maxwell-Boltzmann, Bose-Einstein statistics and Zipf-Mandelbrot Law is presented in the paper. Additionally, the Fluctuation theorem is included. Both results are set in the rigorous probabilistic framework. The system under consideration is composed of fixed number of particles and energy smaller than some prescribed value. The particles are redistributed on fixed number of energy levels and are indistinguishable within one level. Further, the degenerations of energy levels are included and their number increases as the number of particles increase. The three distribution mentioned in the title corresponds to the three asymptotic cases of rate of increases of degenerations as a function of particles. When we take a thermodynamic limit for three cases we basically obtain the Law of Large Numbers and the obtained three means are our distributions. The fluctuations, i.e. the deviation from the mean turns out depends on the Entropy of the system. When its maximum is in inside of the domain we get Gaussian distribution. When it is on the boundary we get discrete distribution in the direction orthogonal to the boundary on which maximum is situated and Gaussian in other directions. The proof is similar for both results. The main part are the properties and asymptotic behavior of Entropy. Due to this we can optimize it and therefore apply probabilistic results which underlying assumptions overlap with ours and eventually get the desired results.


This paper reports on a project started November 1999, which aims at understanding the storytelling structuring processes put into action by children at primary education level. The ultimate goal of this study is to draft a script for a computer tool to support story telling. For this purpose it identifies narrative scheme as the main organizing paradigm of human thinking and the ubiquity of the products of narrative schemes for human life. It then considers the importance of the development of children's narrative competences and the role of narrative, particularly storytelling, for the development of literacy and imagination in the processes of learning and school performance. A brief analysis of research within storytelling software development leads to the conclusion that there is need for greater investment in this area. Finally, the paper describes the various research stages, emphasizing V. Propp's contribution toward story analysis and the need to include children in technology design. (Contains 48 references.)


The objective of this paper is to investigate a new design of an inductive sensor, and its application for measuring tangential displacement. The sensor consists of one stationary inductor and a movable ferrite plate relative to the inductor. Tangential displacement can be measured as a change in the overlapping area between the inductor and the ferrite plate, while their normal distance is constant. The inductance of the inductor changes, so does the resonant frequency of the antenna-sensor system when the ferrite plate moves in one - x axis direction with respect to the stationary inductor. The operating principle of the sensor is tested using the fabricated prototype. The resonant frequency of the system is wirelessly measured. The obtained sensitivity of the planar tangential inductive displacement sensor is 2.44 MHz/mm.


A new electromechanical power-splitting full-hybrid transmission with two shifting elements, namely a four-shaft planetary gear and an electronic continuously variable transmission, is introduced in this paper. This transmission was developed with the aim of combining all the advantages of an internal combustion engine and two electric motors in an optimal way so as to improve the power performance and the fuel economy. The architecture and analogy of the four-shaft planetary gear are analysed, a control strategy is designed, and the engine management system and hybrid control system are calibrated. To evaluate the performance, the control strategy and the calibrated results, nine tests were performed as per the New European Driving Cycle under various initial conditions, different maps and different thresholds. The test results indicate that a four-shaft planetary gear, electronic continuously variable transmission hybrid electric vehicle can realize good fuel economy and good emissions performance except for nitrogen oxide emissions. The best fuel consumption obtained was 5.4 l/100 km. The amount of nitrogen oxide emissions needs to be decreased by optimizing the control strategy of the hybrid control system and calibration of the engine management system in future research.


Archaeology of Intangible Heritage. By Francisco Vaz da Silva. International Folkloristics, Vol. 4. New York: Peter Lang, 2008. 191 pp. In this densely argued book, Francisco Vaz da Silva invites us to uncover die root meanings of the metaphors commonly used in our cultures and, in so doing, recover the lost connections to our "intangible heritage." Although the book's title appears to be paradoxical, since archaeology should deal with "tangible" artifacts, the author competently applies archaeological methodology to investigate the "intangible," conceptual dimension of familiar metaphors and imagery that we regularly use without acknowledging their cosmic connotations. In so doing, Vaz da Silva asks questions that might sound relatively childlike, such as "why should horns and cuckoos be the attributes of the unhappy husband?" (7). Yet his answers to such questions are sophisticatedly formed through careful analysis and examination of key literary works, documents, popular religious texts, and ritual practices from the classical period to contemporary folk beliefs, in Europe as well as in Melanesia. This highly impressive assortment of primary sources, along with Vaz da Suva's archaeological approach to the concepts, helps restore back from oblivion the mythical meanings of otherwise apparently trivial metaphors. This book is divided into three parts. The first part, "Physiology," begins by investigating the notion of the transmissible sexual horns and thereby introduces the reader to the world of esoteric folklores and folk practices. Vaz da Silva focuses in particular on the human body, sexuality, and gender relations in all their grotesque details. The chapters abound with tales of bodily fluids and secretions, drawn widely from sources across time and space. Through such an archaeological project, the reader is brought face to face with a folk theory of anatomy and the gender hierarchy inherent in such a theory. Vaz da Silva convincingly takes the reader on a trip from specific cultural beliefs and practices to a universal folk frame of reference that struggles to explain human existence and connect various observable phenomena under a single, coherent worldview Semen, milk, and menstruation become linked to the wider world of seasons, plants, and animals. This interconnected worldview is precisely what we have lost as metaphors seep into general usage and are reduced to words without meaning. The second part, aptly named "Metaphysics," moves on from the physicality of the first part to the realm beyond the physical. Vaz da Silva takes off from the folk worldview at the end of part one to explore female dominance of the cycle of life and men's struggles to define their existence and superiority within this cycle. The cycle of life then becomes another step in Vaz da Suva's argument to propose that the key characteristic of folk worldview is the cyclical cosmos. The folkloric world that Vaz da Silva describes has no beginning and end. …


PURPOSE: A continuous incinerating boiler using RDF(refuse derived fuel) as solid fuel is provided to reduce discharge of harmful material among exhaust gas by burning gas completely with vortex of the second combustion chamber and supplying air to the combustion chamber sufficiently. CONSTITUTION: A continuous incinerating boil includes a raw material input hopper(18) and a transfer screw having a horizontal RDF supply screw(19) and a vertical RDF supply screw(20). RDF is supplied continuously by the transfer screw and the raw material input hopper, and high temperature air is supplied to the inner periphery of a middle air shutoff cylinder(3) between a first combustion chamber cylinder(5) and a second upper combustion chamber cylinder(4) by a blower(14) to form the vortex. Air is supplied continuously to the solid fuel by a combustion air supply unit, and incomplete combustion gas is moved up along the inner periphery of the first combustion chamber cylinder. Air is incinerated completely at 1100 to 1300 deg.C by receiving air between the first combustion chamber cylinder and the second upper combustion chamber cylinder.


Abstract : The levels of pesticides (Aldrin and Dieldrin) measured in flesh (edible portion) of fish caught from Lake Ladora during June 1973 to January 1975 had not exceeded 0.1PPM. During March 1975, six largemouth bass were harvested from Lake Ladora and sent to Dugway for pesticide analysis. The levels of dieldrin in these fish are higher than those previously reported for Lake Ladora and according to the World Health Organization (WHO) recommendations are potentially harmful. Monitoring of the aldrin and dieldrin levels in fish from Lake Ladora will continue on a quarterly basis or more frequently if deemed necessary.


Saharan tourism in Algeria is promising and can give a boost to the country's tourism and the economic sector. The aim of this study is to measure the tourist appeal of Biskra through its natural and cultural assets. We will try to identify its potential and constraints in order to promote local tourism while taking into account the specificities of our territory. This study will focus on the Biskra province, which is one of the Saharan Algerian cities. It is located in the loop of oases, connecting the north and the south of the country. It is famous for its palm trees, dates (Deglet Nour) and its traditional architecture. Within the framework of spatial planning and tourism development our research theme will focus on the enhancement of local assets in order to promote the tourism sector so that it is equitable and sustainable while respecting moral and cultural integrity of the region. To do so, we opted for a theoretical and analytical approach by consulting a set of bibliographic references, interviewing local officials and conducting field visits. Driven by SWOT analysis (Strengths – Weaknesses – Opportunities – Threats), which is a diagnostic and decision support tool. The results show that our study area is rich in natural and cultural potential. Nevertheless, the development of tourism is lagging behind and it is therefore necessary to seek the tourism model adapted to the specificities of the region and the capacities to be developed to achieve the objectives defined by the SDAT 2030 (Master Plan for Tourism Development).


·A special class of sequences having no adjacent repeated subse quences is discussed. It is shown that "repeat-free" sequences of three symbols having arbitrary length exist. Mo~eover, the exponential growth of the number of such sequences with their length is established.


Trilaurylamine nitrate diluted in dodecane is considered as an extracting agent for plutonium. The use of this solvent is proposed for a tail- end plutonium recovery from irradiated uranium solutions that have already been purified by one or more TBP cycles. Mention is made of general properties of the solvent. The study of the stripping of plutonium is emphasized. The first choice stripping solution is a mixture of sulfuric and nitric acid that gives a final concentrated and purified Pu/sup 4+/ solution. Some alternative purification flowsheets are given. They show that a decontamination factor of 10/ sup 4/ can be attained for Nb- Zr and uranium. Kinetics of the extraction and radiolytic degradation of the solvent are discussed. (auth)


According to the present situation of China's stationary pollution source of flue gas of low concentration of SO2 emissions,and combined with the technical needs of environmental monitoring work; the performance and application of 3 kinds of portable SO2 flue gas analyzer of the the applications at home more by non-dispersive infrared method( a kind of imported analyzer,two kinds of domestic analyzer) have been tested and researched.The test results show that: the basic performance of domestic NDIR portable gas analyzers which measure SO2 in flue gas has been gradually approaching the similar equipment that made in foreign countries,and adapting to China's national condition demand better than the import equipment in the product structure and expanded function.But the domestic equipment needs to be further improved in the rationality of structure,as well as the convenient and ease of use,the stability of product quality,and other aspects.Therefore,in order to promote the performance of the domestic portable flue gas SO2 analyzer,it should be implemented as soon as possible in the technical standards,application specifications and other relevant laws and regulations.


A new formula is derived that generalizes an earlier result for the infinite integral over three spherical Bessel functions. The analytical result involves a finite sum over associated Legendre functions, Pml(x) of degree l and order m. The sum allows for the values of |m| that are greater than l. A generalization for the associated Legendre functions to allow for any rational m for a specific l is also shown.


The article is devoted to the problem of modernization of the Russian society, which is central from a practical and theoretical point of view for the existence of the Russian state. It is connected with the nature of the culture of Russian civilization, with the sociocultural type of personality and society that requires its reformatting. These are both traditional mechanisms involved in the reproduction of Russian society and innovative development factors. The focus is on the modern civilizational Challenge, which has stretched over several decades. Even such a grandiose transformation as the deconstruction of the USSR did not lead to the Answer to the Challenge. A closed, authoritarian type of Russian society with a two-dimensional traditional cultural code can be modernized only by using an external factor as a transformation lever. The article describes the specifics of Russian civilization in connection with the peculiarities of modernization at the stage of transition to post-industrial society. This transition included a crisis of a two-dimensional sociocultural code reflected in Soviet ideology and social practice, overcoming the closure of the country, and using the social and technological innovations of the West. The two-dimensional code did not provide restructuring and transition to post-industrial civilization by borrowing technological and social innovation. Modern ontology of sociality is constructed by synergy of media interactions. Media is a word and deed that designs and formats social reality. At present, the humanities can be anthropologically effective if they turn into media design that designs and formats social reality. The creators of social and anthropological design are social energy actors — scientists, proactive subcultures. The traditional national sociocode is gradually transformed under the influence of globalization, adapted to it, or aggressively extremist enters the fight against postmodernization (fundamentalist extremism). The postmodernization of the Russian society includes its diversification, also manifests itself in a multiplicity of intents into the future. The two-dimensional code of negative identity is overcome, according to the laws of synergy, through chaos and new sociality will be formed either spontaneously or by the method of managed chaos, if domestic managers, who still keep the Russian society in a state of sluggish stagnation, are ripe for it. However, the principle of bifurcation reminds us that the future is ambiguous. Without mastering the art of managed chaos, one cannot take a productive step in social governance and development.


hypothesis. The latter is a standard part of the tool-kit of labour economics. The standard form of the hypothesis states that a firm's output is a rising function of its 'effective labour force' which is the number of employees multipled by their average productivity; and that the latter is a rising function of the real wage rate. It is this assumed relationship between wages and productivity which is important. Solow loosely rationalises it on the grounds that higher wages increase employees' sense of fair treatment which, in turn, raises their morale; and increased morale is assumed to lead to increased productivity. It is then easy to show (Malcomson, 1981) that the firm's optimal policy is to set the wage at the level at which its elasticity of productivity with respect to the wage equals unity. This is the 'efficiency wage' in the sens- that it minimises labour costs per unit of effective labour. There is an associated equilibrium employment level which is inversely related to the efficiency wage. The important point is that the 'efficiency wage' is determined by the productivity function and is, in a wide range of circumstances, invariant to the balance of supply and demand in the labour market. The efficiency wage model can therefore reconcile rational behaviour by firms with the coexistence of fixed wages and involuntary unemployment. In


Outlines a practical method of therapy for developing the skills needed to enrich personal relationships and avoid problems that commonly occur.


The increased number of younger children in early years settings has brought to the fore the realisation that two-year-olds have their own unique set of needs. This is especially true when dealing with feelings.


Summary The chemical composition and antimicrobial activity of the essential oil of Mentha pulegium L., was investigated. Analysis of essential oil using gas chromatography(mass spectrometry (GC(MS) revealed at least 15 components. The chemical composition showed some similarity with essential oil of M. pulegium from other regions. It was found that pulegone was the major component with 69.22% of the essential oil and menton accounting for 18.98%. The antimicrobial activity of essential oil was then evaluated against four bacteria important in food industry. According to the results, essential oil from M. pulegium showed its highest antibacterial activity on S. mutans followed by K. oxytoca , P. aeruginosa and E. coli . According to our literature survey, this is the first report on the quantitative composition and antibacterial activity of the essential oil from Mentha pulegium L. grown in Gilan, a northern province of Iran.


A rocket borne spectrometer system sensitive to 6–80 keV photons is described. The system includes a shutter‐collimator that makes it possible to measure the contribution to the background due to charged particle interactions in the mass of the rocket payload. Also described is a detector rotation mechanism that allows the look angle of the detector with respect to the rocket axis to be changed during flight.


I wish to express my deepest gratitude to the members of this, one of the most important sections of the American Medical Association, for having chosen me as their chairman. This honor comes to but few of us in a lifetime, and when I was selected I could not but feel that the honor carried with it a great responsibility. In accepting the position, it will probably be remembered, I said: "The success of a year's work would not be accomplished by the chairman but by the work of each individual member." In looking over the program one must be impressed by the wealth of subjects to be discussed, as well as the names of the authors of the papers. This certainly should convince us that we are to enjoy a treat seldom offered in bodies of this character. Should I attempt to add anything of a scientific nature, I


The invention discloses an enzymatic pretreatment process for improving milling characteristic of brown rice. In the enzymatic pretreatment process, before milling of the brown rice, food-grade cellulase solution with certain volume, mass, concentration and pH value is sprayed at certain temperature at intervals according to certain single additive amount so that the water content of brown rice reaches milling requirement, cortical cellulose is partly degraded, and the cortical strength of rice kernels is lowered, thereby further reducing the grinding force needed for milling, decreasing broken rice generated during the milling process and lowering milling energy consumption. The enzymatic pretreatment process has no toxic side effects and is beneficial to the improvement of the economic benefit of rice processing enterprisers.


The Chemical Valley in France, a territory composed of various industrial platforms, is facing sustainability challenges. These business parks are located in the vicinity of strategic resources (water networks, pipeline networks). Their organisation allows the pooling of services, equipment and resources. Industrial ecology reveals existing and potential industrial synergies. Environmental management services within companies include facility and employee safety, waste management and effluent treatment; however, they do not develop local trade. The aim of the research conducted on an industrial consortium is to create and strengthen synergies between willing industrial entrepreneurs by testing various decision support tools. The proposed methodology in industrial ecology consists in identifying the various flows, defining collective action strategies, then comparing synergy scenarios using a multi-criteria analysis (acid-base exchange, wastewater sludge valorisation).


Nowadays LADAR system set on practical moving platform is purposed to detect real-time velocity as well as precise distance and direction evaluation for safe landing or obstacles avoiding. On account of narrow band, brief algorithm, non-modulated CW Doppler LADAR based on optical heterodyne principle could acquire the velocity of multiple targets with high frame frequency, high SNR ratio while no velocity ambiguity. In this paper, a non-modulated 1064nm CW Doppler fiber LADAR system with high frame frequency as well as high velocity precision is proposed. The experimental result of the system shows a velocity precision of 6.65mm/s, and a velocity detection frame frequency of 20FPS, which essentially meet the practical demands.


This brief presents theoretical guarantees for stability and performance for the singular value decomposition (SVD) system with subsystems that are linear and first order. The SVD system reduces the dimension of the control input. It is used to meet the rank-one input constraint imposed by the row-column structure. The row-column structure reduces the number of inputs required to control mn subsystems to m + n. Although the subsystems are linear and first order, they can be dynamically coupled and are coupled nonlinearly by the SVD of the control input. Thus, the entire system is of order mn and nonlinear. Lyapunov stability and performance analysis demonstrates the effect of the SVD dimension reduction through comparisons to a system with full-rank inputs. The analysis also provides convenient methods for control design. Simulation examples demonstrate the use of the SVD system, theoretical results, and the SVD system's robustness with respect to noise and nonlinearities.


The solar system which had a beginning, 4.6 billion years ago is discussed. The atoms that make up the solar system are much older than that, however: they were also part of the universe that existed before the solar system formed. The presence and location of the atoms of silicon, iron, calcium, that make up the Earth and other planets before there was a solar system is questioned. Astronomical it is shown that they existed in tiny dust grains which, along with molecules of gas, wandered about in the vast reaches of space between the stars of our galaxy. The solar system was formed when one particular cloud of interstellar dust and gas became dense enough to be gravitationally unstable: the gravitational pull that dust grains and gas molecules exerted on one another caused the cloud to collapse.


In order to keep up with the changing economic environment, graduates from business schools must be prepared to face different challenges. In fact, it is the educational system that must be configured properly, so it can create student competencies in a dynamic way. A research has already been conducted on the subject of dimensions in education for international business, and identified the most important ones (Tartavulea et all, 2012). The purpose of this article is to analyze some of the informatics solutions for business simulation and compare their mechanisms and results in terms of student satisfaction regarding the preparation for the labor market. As the economic environment is becoming more complicated in terms of financial markets and products diversification, the new comers in the labor field must have the knowledge to understand the mechanisms of the market and the skills necessary to keep businesses on top of the wave.


Knowing and understanding the new middle school "P.E. and Health curriculum is the first step to Implement it. The essence of the old curriculum is "Knowledge", while the essence of the new curriculum is "Experience". The "experience"curriculum lays emphasis more on the process (especially the ability ,attitude and value during the process of presenting knowledge through direct experience and direct knowing )than on the transmission of knowledge . The teaching distinction between the old and new curriculum is the change of the learning mode, so it is necessary to construct the microstructure of the new curriculum.


&dquo;The third chapter further describes such an exercise, with reference to a very simple example. In order to demonstrate the possibility of using cross-impact analysis as a way of relating intuitive information of a global nature to a model of a subsystem of social reality, the exercise is pursued so as to link the results of the cross-impact analysis to an econometric model. &dquo;A [25-item] list of references to other publications dealing with cross-impact analysis is also provided.&dquo;


Abstract: Over a nine‐year period, 1,223 patients with cerebrovascular accidents were admitted to Montebello State Hospital, a chronic disease institution.


A perspective on large marine ecosystems food chain dynamics on the northeast continental shelf of the United States - the shelf-edge exchange programme warm-temperate food chains of the southeast shelf ecosystem coastal-shelf food chains of the eastern Bering Sea spatial/temporal scales of secondary production in the California current the status of main species of fish in the variable ecosystems of the Barents Sea global epidemic of noxious phytoplankton blooms and food chain consequences biomass, yield models and food chain theory on the causes for variability of fish populations - the linkage between large and small scales empirical versus theoretical - a critical review of fisheries yield models for large marine ecosystems Part contents.


A physician in clinical practice does not usually order patients with PsA, and their presence has been linked to autoantibody testing to aid subsequent diagnosis or for disease activity. These studies suggest that proteins in the monitoring disease activity in patients with psoriasis or psoriatic arthritis (PsA), although a variety of autoantibodies are present in these patients. Our understanding of autoantibodies in psoriasis and PsA is limited.


Objective:To explore the efficiency and safety of hypoxia-limit light programme in avoiding the retinopathy of prematurity(ROP) of very low birth weight infants(VLBWIs).Methods: Forty VLBWIs were randomly divided into hypoxia limited light group(Group II) and routinely oxygenated group(Group III) with 20 cases in each group.Other fifteen VLBWIs who did not need any oxygen or hypoxia therapy for less than five days were considered as the control group(Group I).All VLBWIs accepted eyeground examinations at the rectified age of 33,34,35 and 36 gestational weeks.According to the results of ROP,kept these eyeground examinations up to the retinal capillaries were mature,recording the visit sight,the occurrence of brain palsy(BP) and branch-pulmorary dysplasia(BPD) and so on.Results:The occurrence of ROP in group III amounted to 40%,showing significantly higher than those in group I and group II.The time that VLBWIs suffered from ROP were between 34 to 36 gestational weeks,the average time was 35.5 gestational weeks.The birth weight,gestational age,time of hospitalization and sepsis were related to ROP.Apart from these risk facts,the occurences of ROP in group I were relative to one-minute Apgar grade and the blood pressure and that in group II to BE-10.With logistic comprehensive analysis,only low birth weight and gestational age were found to be the major causes of ROP(P0.05).Forty cases of these VLBWIs followed for 10~16 monthes showed that the sight abnormality and BPDs amounted to 50% and 25% respectively in group III,which were significant higher than these in group I and group II(P0.05).But there was no significant difference in occurence of BP as a whole(P0.05).Conclusion:The application of hypoxia-limited light programme is a valid and safety therapy.It would be able to avoid ROP and decrease the occurrence of BPD,but couldn't increase the occurence of BP.


Three decades ago, large ICF lasers that occupied entire buildings were used as the energy sources to drive the first X-ray lasers. Today X-ray lasers are tabletop, spatially coherent, high-repetition rate lasers that enable many of the standard optical techniques such as interferometry to be extended to the soft X-ray regime between wavelengths of 10 and 50 nm. Over the last decade X-ray laser performance has been improved by the use of the grazing incidence geometry, diode-pumped solid-state lasers, and seeding techniques. The dominant X-ray laser schemes are the monopole collisional excitation lasers either driven by chirped pulse amplification (CPA) laser systems or capillary discharge. The CPA systems drive lasing in neon-like or nickel-like ions, typically in the 10 – 30 nm range, while the capillary system works best for neon-like argon at 46.9 nm. Most researchers use nickel-like ion lasers near 14 nm because they are well matched to the Mo:Si multilayer mirrors that have peak reflectivity near 13 nm and are used in many applications. As a result, the last decade has seen the birth of the X-ray free electron laser (XFEL) that can reach wavelengths down to 0.15 nm and the inner-shell Ne laser at 1.46 nm.


We use the statistical model of Zhang et al. to calculate parton distributions in hadrons. The model does reasonably well in predicting the distributions of partons in the proton, including the (d ‐ ū) excess in the proton sea. We extend the model to calculate quark and gluon distributions in the pion, kaon, and the pentaquark. The hadrons are described in terms of quark and gluon Fock states. Detailed balance between each pair of states is assumed, from which the coefficients of the Fock state expansion are determined. The parton distribution functions are found in the hadron rest frame from a Monte Carlo calculation. The results are evolved to appropriate QCD scales for comparison with experiment. Despite its simplicity, the model is in good agreement with the experimentally measured distributions of partons in the pion and kaon. This project has included significant participation by undergraduates at Seattle University, made possible by support from the Research in Undergraduate Institutions Program o...


the purpose of the study was to compare the performance of boys and girls in home economics at grade five school levelat Mandanga Primary school in Mongu district of Western Province in Zambia. The research instruments used in this research included classroom observations, focused groups and semi-structured interviews. Data collected was analysed inductive approach using constant comparative data analysis. The study has revealed that there was balance on the gender performance of Home Economics among the grade five classes at Mandanga Primary School in Mongu district of Western Province in Zambia.


The Short Message Service (SMS) is one of very popular kind of superior and well-tried services with a global availability in GSM networks. This paper deals with an SMS security for mobile communication. The transmission of an SMS in GSM network is not secure; therefore it is desirable to secure SMS by additional encryption. A proposed approach, based on encryption and digital signature efficiently embeds the confidentiality, integrity, authentication, and non-repudiation in the SMS messages. In the next part, there is the description of design and implementation of the application, which encrypts SMS by DES, Triple DES, AES and Blowfish algorithms and finally signs SMS by DSA or RSA algorithm respectively. At the end, we described attacks on secured SMS and future extension of the application.


Inter-cell interference is a major issue in OFDMA networks. One approach to reduce the amount of interference is to use beam forming antennas. Further interference mitigation is achieved if neighbor base stations coordinate the directions of their beams. This paper presents a novel distributed interference coordination algorithm using main-lobe steering beam formers. Our algorithm does not require any explicit signaling between base stations. Also, it does not require any additional channel measurements to be signaled to the base stations besides those already performed for basic operation. Our evaluations show that significant performance gains can be achieved even with non-greedy traffic. Index Terms – Interference coordination, beam forming antennas, COMP


This study investigates two vocabulary exercises where the participant students receive an assigned set of words to put into sentences, one being a more traditional written exercise, the other bein ...


IoT system becomes a hot topic nowadays for smart home. IoT helps devices to communicate together without human intervention inside home, so it is offering many challenges. A new smart home IoT platform powered using electromagnetic energy harvesting is proposed in this paper. It contains a high gain transmitted antenna array and efficient circularly polarized array rectenna system to harvest enough power from any direction to increase lifetime of the batteries used in the IoT system. Optimized energy consumption, the software with adopting the Zigbee protocol of the sensor node, and a low-power microcontroller are used to operate in lower power modes. The proposed system has an 84.6-day lifetime which is approximately 10 times the lifetime for a similar system. On the other hand, the proposed power management circuit is operated at 0.3 V DC to boost the voltage to ~3.7 V from radio frequency energy harvesting and manage battery level to increase the battery lifetime. A predictive indoor environment monitoring system is designed based on a novel hybrid system to provide a nonstatic plan, approve energy consumption, and avoid failure of sensor nodes in a smart home.


Purpose – Care integration has been the hallmark of most proposed solutions to current and prospective challenges of health systems. However, it is an imprecise umbrella term encompassing heterogeneous models and little substantive knowledge exists on the basic mechanisms leading to positive outcomes. This study aims to address this gap by identifying the environmental conditions and the configurations of factors associated with service delivery success in integrated care initiatives.Design/methodology/approach – On the basis of an extensive literature review, an analytical framework aimed at structuring and interpreting the relations between contextual, cultural and organizational factors and the outcomes of integrated care initiatives is proposed. The framework is applied to four successful cases of care integration in the USA, Canada, Italy and Switzerland.Findings – The results suggest that positive outcomes mainly depend on the correct matching of macro‐level factors with a balanced mix of operating ...


The Z‐scheme photocatalytic system for water splitting based on semiconductors has exhibited great potential for H2 fuel production from renewable resources. In this work, we constructed g‐C3N4/Au/C‐TiO2 hollow spheres as an all‐solid‐state Z‐scheme photocatalytic system with Au nanoparticles as the electron mediator. The as‐synthesized g‐C3N4/Au/C‐TiO2 photocatalyst showed a remarkably enhanced photocatalytic H2 evolution rate under visible‐light irradiation (λ>420 nm), which was 86 and 42 times higher than those of pure C‐TiO2 and g‐C3N4, respectively. The enhancement of photocatalytic performance can be mainly attributed to the intentionally designed Z‐scheme system, which not only promoted the efficient transfer and separation of photogenerated electron–hole pairs, but also retained the strong redox ability of the charge carriers. In addition, the Z‐scheme system also achieved high visible‐light absorption and utilization owing to the surface plasmon resonance (SPR) effect of Au nanoparticles and hollow structures of C‐TiO2. All the factors synergistically promote the photocatalytic activity of the g‐C3N4/Au/C‐TiO2 hollow nanospheres, providing a promising method for the rational design of highly efficient visible‐light‐driven photocatalysts.


While much is known about process level control on N2O production by nitrification and denitrification, knowledge of the environmental controls responsible for site variation in annual N2O fluxes on ecosystem level is low. Our goal was to improve existing concepts of controls on N2O fluxes. We measured N2O emission weekly or biweekly during 1 year in 11 temperate forest ecosystems using closed chambers. We identified three types of forest with different temporal emission patterns: forest with seasonal, event‐based and background emission patterns. Comparison of annual data sets from literature showed that most temperate forests had low N2O emissions throughout the year (background emission pattern) with mean annual fluxes of 0.39 ±0.27 kg N ha−1 yr−1 (n = 21). Event‐based emission patterns were observed during frost/thaw periods and after rewetting. Highest fluxes up to 72 kg N ha−1 were emitted from a drained alder forest with organic soil in 46 weeks, followed by well drained tropical and temperate forests with seasonal emission patterns and fluxes between 2 − 6 (n = 3) and 1 − 5 kg N ha−1 yr−1 (n = 4), respectively. Seasonal emission patterns were explained by combined effect of high annual precipitations; broad leave trees; amount and structure of organic upper horizon; high mineral bulk densities; and plant community. These state variables reduce gas diffusivity so that oxygen demand by microorganism and roots exceeded oxygen supply during wet and warm periods (>10° C). The resultant upper mean level was about 100 μg N2O−N m−2 h−1 in both temperate and tropical forests. Annual N2O losses of the seasonal emission type were controlled by both duration and upper mean level of the periods with high emissions. We conclude that "short‐term controls" of climate determine the duration of high emissions, whereas "long‐term controls" by state variables determine the difference between background and seasonal emission types.


This exploratory paper aims to discuss how community is fostered in semi-public restrooms on a college campus. While previous research has been undertaken in similar semi-private environments, this paper differs by simultaneously offering the researchers' reflective insights in tandem with participants' input on the research question. We begin by unpacking the challenges around Participatory Design (PD) activities that are undertaken in sensitive and private interior environments. Gathering perceptions of these sensitive spaces required methods that allowed for both anonymity and a communal approach through the use of provocative and evocative probes such as comment boxes and graffiti wall posters. This paper not only catalogues the findings of this research but also documents the difficulties in utilizing a participant-led approach, gaining access to sites and participants, and countering our own biases throughout the study's construction. Through researcher accounts and participatory data analysis, the researchers offer a focused reflection on a possible new frontier for advancing PD methods in sensitive environments through playful probes. The contribution of this paper offers six lessons on the efficacy of using probes in semi-private environments, with playfulness as a primary driver of engaging participants.


Introduction : Aplastic anemia (AA) is a syndrome characterized by peripheral pancytopenia with hypocellular marrow. Acquired idiopathic aplastic anemia is the most common variety, and its treated with cyclosporine-A, or Antithymocytic globulin or with Bone marrow transplantation. Aim: Study of comparing response to treatment with CSA alone versus the combination of ATG + CSA in aplastic anemia patients. Materials and Methods : This study was a prospective randomized study, conducted after getting approval from Institution ethical committee and conducted over 18 months. All patients underwent a detailed clinical examination and laboratory investigations. Diagnosed patients of acquired idiopathic aplastic anemia without active infection, otherwise not eligible for bone marrow transplantation were recruited. Patients were randomized to receive either CSA alone or the combination of ATG and CSA according to their choice. Assessment of response to therapy was made at the end of 3 months. Observations and Results: After the diagnosis, 31 patients were enrolled. The age of the patients ranged from 10 to 65years. Male to female ratio was 1.8:1. The average duration of symptoms before presentation was 8 months. Almost all the patients were requiring regular component support with packed red cells and platelets before starting therapy. 20 patients were randomized to receive CSA. Out of 20, 3 patients were lost to follow up due to financial constraints and 1 patient discontinued therapy due to renal dysfunction, finally 16 patients were analyzed. In this group 9 out of 16 (56.5%) responded to treatment. 11 patients were assigned to ATG & CSA group. 3 patients died within two months of therapy, these were excluded from the study, and finally 8 patients were analyzed. In this group 5 out of 8 (62.5%) responded. Conclussion: CSA treatment is as efficacious as ATG+CSA combination therapy for acquired idiopathic aplastic anemia, otherwise not eligible for BMT from HLA-identical siblings.


Extracellular nucleotides and nucleosides are important signaling molecules in the lung. Nucleotide and nucleoside concentrations in alveolar lining fluid are controlled by a complex 26 network of surface ectonucleotidases. Previously, we demonstrated that influenza A/WSN/33 27 (H1N1) virus resulted in increased levels of the nucleotide ATP and the nucleoside adenosine in 28 bronchoalveolar lavage fluid (BALF) of wild-type (WT) C57BL/6 mice. Influenza-induced acute 29 lung injury (ALI) was highly attenuated in A 1 -adenosine receptor-knockout mice. Because AMP 30 hydrolysis by the ecto-5'-nucleotidase (CD73) plays a central role in and is rate-limiting for 31 generation of adenosine in the normal lung, we hypothesized that ALI would be attenuated in 32 C57BL/6-congenic CD73-knockout (CD73-KO) mice. Infection-induced hypoxemia, 33 bradycardia, viral replication, and bronchoconstriction were all moderately increased in CD73- KO mice relative to WT controls. However, post-infection weight loss, pulmonary edema, and 35 parenchymal dysfunction were not altered. Treatment of WT mice with the CD73 inhibitor 5'- 36 ( α , β -methylene) diphosphate (APCP) also had no effect on infection-induced pulmonary edema 37 but modestly attenuated hypoxemia. BALF from both CD73-KO mice and APCP-treated WT 38 mice contained more IL-6 and CXCL-10/IP-10, less CXCL-1/KC, and fewer neutrophils than 39 BALF from untreated WT controls. BALF from APCP-treated WT mice also contained less 40 alveolar macrophages and more TGF- β than untreated WT BALF. These results indicate that 41 CD73 is not necessary for development of ALI following influenza A virus infection, and 42 suggest that tissue non-specific alkaline phosphatase may be responsible for increased adenosine 43 generation in the infected lung. However, they do suggest that CD73 has a previously 44 unrecognized immunomodulatory role in influenza.


etica de las aleaciones de Fe80B10Si10 y Fe78B13Si9 es discutida. Descriptores: Cintas amorfas de FeBSi; aleaciones ferromagnblandas; ant ´ ermico. The thermal and magnetic properties of soft magnetic amorphous ribbons Fe80B10Si10 and Fe78B13Si9 were studied using differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA). The characterization of the crystallization kinetics via DSC is presented. The appearance of a two-stage crystallization process is observed. Changes in the magnetization state of the ribbons due to nanocrystallization processes were observed via TGA analysis. A comparison between thermal and magnetic properties allowed the determination of the primary crystallization temperature, Tp1, and of the amorphous Curie temperature, T H Curie;am, in these compounds. The influence of the amount of Boron on the thermal and magnetic stability of Fe80B10Si10 and Fe78B13Si9 alloys is discussed.


The optimum conditions of stereoptics in relation to man's capabilities of distance judgment are discussed in this paper. It is suggested that by using stereo-optical instrumentation combined with the apparent movement phenomenon, a better visual effect will be produced than by using the stereoptic effect alone.