Allogeneic stem-cell transplantation (SCT) with both myeloablative and reduced-intensity conditioning (RIC) is effective therapy in AML/MDS. However, the relative merits of each may differ in different settings. To define the role of dose-intensity we analyzed SCT outcomes of 112 consecutive patients (pts) with AML/MDS transplanted over a 5-year period. The median age was 50 years (18–70). Eighty-five patients had AML (39 secondary) and 17 had MDS (all with excess of blasts). Fifty-eight had active disease at SCT (>10% marrow blasts) and 54 were in remission. The donor was HLA-matched sibling (n=58), 1-ag mismatched related (n=6) and matched-unrelated (n=48). Forty-five pts met eligibility criteria for standard myeloablative conditioning and were given intravenous-busulfan (12.8 mg/kg) and cyclophosphamide (ivBuCy). Sixty-seven pts were considered non-eligible for standard myeloablation due to advanced age (over 55 years for sibling SCT or over 50 years for mismatched or unrelated SCT), extensive prior therapy, organ dysfunction, recent fungal infection or poor performance status. These pts were given RIC with fludarabine and intravenous-busulfan (6.4 mg/kg, FB2, n=41) or modified myeloablative regimen with fludarabine and myeloablative doses of intravenous-busulfan (12.8 mg/kg, FB4, n=26). The median age of this group was 55 years compared with 42 years in the first group, and a larger proportion had SCT from unrelated donors. With a median follow-up of 22 months (2-62), 63 pts are alive and 49 have died (34 relapse, 15 non-relapse causes). Overall survival (OS) at 2 years was 50%, 49%, and 47% after ivBuCy, FB4, and FB2, respectively (p=NS). Non-relapse mortality was higher after ivBuCy, 22% Vs 8% and 8%, respectively (p=0.05) although these patients were younger and in a better medical condition. This difference was related to higher risk of acute GVHD grade III-IV after ivBuCy while deaths due to organ toxicity were rare in all groups. Relapse rates were lower after ivBuCy but not reaching statistical significance. Active disease at SCT was the most significant predictor of reduced survival in multivariable analysis (HR 4.5, p=0.0001). SCT from unrelated donor and poor prognosis cytogenetics had borderline significance while advanced age and secondary disease had no prognostic significance. Myeloablative and RIC regimens had similar outcomes when leukemia was in remission at SCT with a trend for better outcome with RIC; estimated 2-year OS been 60%, 68% and 80% after ivBuCy, FB4, and FB2, respectively (p=NS). However patients with active disease could only be salvaged by myeloablative conditioning (classical or modified). Among the later group, OS was 45% and 39% after ivBuCy and FB4, respectively, but no FB2 recipient survived (p=0.02). These observations suggest that RIC is associated with favorable outcome and low toxicity in pts in remission at SCT and therefore can be further studied in prospective trials comparing it to myeloablative regimens even in pts eligible for the later. However, RIC is a poor option for pts with active disease. Those not eligible for standard myeloablation could still tolerate modified myeloablation and enjoy its merits. The modified myeloablative regimen has low toxicity and similar cytoreductive effect and therefore can be further studied in prospective studies comparing it to standard myeloablative regimens even in pts eligible for the later.


The article utilizes qualitative data from two Canadian case studies to address this issue. The two cases reveal that market-embracing austerity is driving the erosion of workplace participation, both in terms of the level of control workers exercise over their day-to-day task and representative security. The article is divided into four sections. The first provides a literature that begins with outlining the impact of austerity in the NPSS sector, followed by prospects for employee participation among the Canadian/Ontario NPSS organisations in this context, and research questions. The next section outlines the study's method, followed by the findings, discussion and concluding sections.


Interferon regulatory factor 2-binding protein 2 (587 aa, ~61 kDa) is encoded by the human IRF2BP2 gene. This protein plays a role in the negative regulation of interferon expression.


Risk allocation in contracts is an important issue for both economics and law. It questions the theoretical, methodological, and empirical foundations of economic and legal analysis. It also offers valuable ground for comparative legal-economic inquiry. The article aims at providing insights into that general approach, and proceeds with an articulation of theoretical and empirical analysis. The paper first offers a critical analysis of key economic hypotheses based on law, contract law, and legal institutions, notably the courts. It focuses on various components of the New Institutional Economics that deal with the notion of contractual incompleteness. The emphasis is put on two central issues: the contract-institution relationship, and the scope of incompleteness as a guide to empirical research into the economic dimensions of contract law. The second part of the article compares and evaluates the significance of the economic concept of incompleteness and the French legal notion of unpredictability (imprevision), which relates to the notion that the administrative courts have the power to rule on cases in which the occurrence of unforeseen events affects the contractual equilibrium as set up ex ante. The analysis then moves toward a search for a legal and empirical articulation of uncertainty in the future. The article argues that positive legal provisions in contract law enable co-contractors to set up a framework in which the consequences of unforeseen events can be addressed. Legal provisions such as those relating to conditional duties, aleatory contracts, force majeure, fortuitous events, price revisions, or hardship, are examples of tools that allow for a significant amount of predictability in contractual relations, particularly in long-term contracts. We then offer an empirical analysis of the specific legal notion of unpredictability (imprevision). Our analysis is based on legal data, namely decisions by the French State Council (Conseil d'Etat) that deal with a request for compensation by the State for the economic consequences of unforeseen events for suppliers. A descriptive statistical analysis is linked to a study of the legal instructions given by the State to its contracting officers. A comparison of price determination provisions under US and French public procurement law is then made.


Abstract: Interest group activation is examined comparatively in the context of the political processes of adoption of three major welfare reforms in the 1990s, respectively pension reform in Argentina and Mexico, and public health reform in Colombia, in order to assess the degree to which they followed democratic procedures. The events marking these processes are selected on the basis of six hypotheses: adoption resulted from the free interplay of parliamentary coalitions; societal interest groups influenced parliamentary debates; the Executive mediated between power groups rather than acted as a power group in its own right; international credit agencies have pressured debtor countries into carrying out the reforms; private health care providers, insurance, banking and pharmaceutical interests exerted pressures on government to carry out the reforms; and technocrats who launched the reforms were linked to private interests. The paper concludes that the political processes through which the three reforms were adopted have been fairly democratic, although the old corporatist systems in Argentina and Mexico, and the old exclusionary liberal party in Colombia were indispensable back-ups to ensure parliamentary support. The weakness of alternatives to the governmental projects, rather than stem from behind the scene maneuvering and pressuring by interest or power groups, are attributed to the weakness of opposition parties in countries that have barely begun to practice politics in multi-party systems. It also stems from the urgency, as perceived by the Executive branches and their allies, to demonstrate to the globalized world that their country is a safe place in which to invest.


Background: Cough is protective reflex caused by obstruction or irritation of airway. Many medication available for the treatment of dry cough. But it causes sedation and drowsiness in children. Considering the adverse effects produce by the medication, we consider this study as the ginger and honey is used in Indian family, and in Ayurveda ginger and honey is used for treatment of dry and productive cough. Methods: We include the patients who attended the pediatric OPD complaining dry cough. We design the questionnaire and for the measuring the severity of dry cough. We divide the patient into four groups received standard treatment and ginger and honey mixture. We compared the end result with standard treatment statistically by using unpaired student "t" test was used along with two-way analysis of variance (ANOVA) test. Results: We include 100 patient in this study. We got amazing result of this study ginger and honey required less time for recovery and also sedation and drowsiness not occurred in the ginger and honey group as compared to dextromethorphan (p value ˂0.005). Conclusions: After seeing above encouraging result, and along with advantage of natural product with no adverse we can advise the honey and ginger therapy for treatment of dry cough.


Visual data play a crucial role in modern society, and the rate at which images and videos are acquired, stored, and exchanged every day is rapidly increasing. Image compression is the key technology that enables storing and sharing of visual content in an efficient and cost-effective manner, by removing redundant and irrelevant information. On the other hand, image compression often introduces undesirable artifacts that reduce the perceived quality of the media. Subjective image quality assessment experiments allow for the collection of information on the visual quality of the media as perceived by human observers, and therefore quantifying the impact of such distortions. Nevertheless, the most commonly used subjective image quality assessment methodologies were designed to evaluate compressed images with visible distortions, and therefore are not accurate and reliable when evaluating images having higher visual qualities. In this paper, we present a dataset of compressed images with quality levels that range from high to nearly visually lossless, with associated quality scores in JND units. The images were subjectively evaluated by expert human observers, and the results were used to define the range from high to nearly visually lossless quality. The dataset is made publicly available to researchers, providing a valuable resource for the development of novel subjective quality assessment methodologies or compression methods that are more effective in this quality range.


Abstract Let | | be a discrete non-archimedean absolute value of a field K with valuation ring 𝒪, maximal ideal 𝓜 and residue field 𝔽 = 𝒪/𝓜. Let L be a simple finite extension of K generated by a root α of a monic irreducible polynomial F ∈ O[x]. Assume that F¯=ϕ¯l$\overline F = \overline \varphi ^l$ in 𝔽[x] for some monic polynomial φ ∈ O[x] whose reduction modulo 𝓜 is irreducible, the φ-Newton polygon Nφ¯(F)$N\overline \phi \left( F \right)$ has a single side of negative slope λ, and the residual polynomial Rλ(F )(y) has no multiple factors in 𝔽φ[y]. In this paper, we describe all absolute values of L extending | |. The problem is classical but our approach uses new ideas. Some useful remarks and computational examples are given to highlight some improvements due to our results.


The Hedgehog network includes canonical and noncanonical signaling modules important for development, homeostasis, and disease. Members of the conserved Hedgehog (Hh) family of secreted proteins play fundamental roles during embryonic development and homeostasis of adult tissues. Hh signal transduction uses an unusual derepression mechanism, in which Hh binding to its receptor component Patched (Ptc) inhibits the capacity of Ptc to repress the heterotrimeric guanine nucleotide–binding protein–coupled receptor Smoothened (Smo). Activation of Smo is accomplished through phosphorylation and subcellular translocation from intracellular vesicles to the plasma membrane and, in vertebrates, also to the primary cilium. This Review focuses primarily on the signaling modules that are set in motion by binding of Hh to Ptc: the "canonical" pathway through which Smo promotes activation of the Gli family of transcription factors, the noncanonical type I pathway in which Ptc modulates cell proliferation and survival independently of Smo, and the noncanonical type II pathway by which Smo regulates the actin cytoskeleton through G inhibitory proteins and small guanosine triphosphatases. Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic and adult structures, and disruption of Hh signaling pathways results in various human diseases. Here, we provide a comprehensive review of the signaling pathways regulated by Hh, consolidating data from a diverse array of organisms in a variety of scientific disciplines. Similar to the elucidation of many other signaling pathways, our knowledge of Hh signaling developed in a sequential manner centered on its earliest discoveries. Thus, our knowledge of Hh signaling has for the most part focused on elucidating the mechanism by which Hh regulates the Gli family of transcription factors, the so-called "canonical" Hh signaling pathway. However, in the past few years, numerous studies have shown that Hh proteins can also signal through Gli-independent mechanisms collectively referred to as "noncanonical" signaling pathways. Noncanonical Hh signaling is itself subdivided into two distinct signaling modules: (i) those not requiring Smoothened (Smo) and (ii) those downstream of Smo that do not require Gli transcription factors. Thus, Hh signaling is now proposed to occur through a variety of distinct context-dependent signaling modules that have the ability to crosstalk with one another to form an interacting, dynamic Hh signaling network.


Developing appropriate programs for students with autism has been an increasingly complex task for parents, schools, and other stakeholders. Parents of students with autism have challenged the appropriateness of proposed school district programs, and these disputes represent the fastest growing and most expensive area of litigation in special education. In this article, 68 hearings and cases were reviewed. The article discusses the outcomes of administrative and judicial decisions related to appropriate programs for children with autism. Three primary factors were identified: Individualized education program (IEP) goals must be matched to evaluation data, IEP team members must be qualified to develop programs, and the methodology selected must be able to assist the students in achieving identified IEP goals. Implications for school teams are discussed.


Eu2+ doped alkaline earth metals such as strontium aluminate, calcium aluminate and barium aluminate prepared by using modified combustion synthesis method at 600°c with Urea as fuel. Crystal structure is determined by using XRD and the sample confirmation by using the FTIR. The effect of the host material on the photoluminescence (PL) and phosphorescence properties were studied by using the Hitachi F-7000 spectrofluorimeter equipped with a 450W Xenon lamp, in the range 200-650 nm. The emission spectra of Eu2+ range from 450 to 500nm in the Blue to aqua region and the transition 4f7-4f6 5d1. The observed emission in CaAl2O4 is 440nm.


The analysis of the research studies of the physical health of students gives disappointing data of systematic and sharp decline in the level of physical development and health of young people from year to year. According to the experts, one of the reasons for the current situation is the lack of the necessary level of motivation and interest in physical culture and sports among students. To solve this problem, the authors propose to use the system of exercises named Hot Iron. It is revealed that trainings according to this system have a positive effect both on the level of physical development of students and their level of motivation for regular and proper exercises.


The recent discovery of specialized sensory neurons that bind peptides in an MHC-like fashion has revealed the long-sought odorants used to recognize the MHC genotype and phenotype of other individuals. The odorants are the same MHC peptides used during immune recognition, which provides the molecular logic linking selection acting on MHC-mediated behaviors with selection acting on immune recognition; both processes influence the evolving peptide binding properties of MHC molecules. The primary function of these chemosensory mechanisms for detecting MHC-mediated odors appears to be mating preferences (observed in humans and many vertebrates) that preferentially produce offspring more resistant to both infectious and genetic disease. Recent experiments are beginning to discriminate the relative importance of these different disease-reducing mechanisms. Introduction MHC-mediated mating preferences were discovered 30 years ago in mice [1]. Since then, experiments have demonstrated that MHC-associated odors can be detected by mice, rats, salmon, sticklebacks and humans. MHC-mediated mating preferences have also been documented in 11 additional species (including humans), spanning most vertebrate taxa (mammals, birds, fish and reptiles). In addition, it is known that mating preferences can be reversed by cross-fostering, which makes familial imprinting the behavioral counterpart to thymic education (see glossary). A variety of other MHC-influenced behaviors have been documented, including kin recognition during cooperative behavior and pregnancy block induced after male territory takeovers (Bruce effect) [2 ]. These data suggest that MHC-mediated mating preferences (and related behaviors) are a general trait found in vertebrates [3 ], despite the failure to find such behavior in a few studies [2 ]. The apparent function of MHC-mediated mating preferences is to reduce disease in progeny by preferentially producing pathogen-resistant MHC genotypes and/or by using the MHC as a marker of relatedness to avoid inbreeding. This is a remarkable biological story about immune recognition genes that also influence complex behaviors in order to reduce disease in progeny; why then is this story often missing in immunology textbooks? One reason is that the mechanism of how individuals detect the MHC genotype in themselves and in others had remained elusive. However, the recent demonstration that MHC peptides (see glossary) are the neuron-activating chemosignals has removed a major barrier to linking MHC genes with their associated behaviors. In this article, we review the experiments that led to the discovery of these sensory neurons, our current mechan-istic understanding of how the MHC genotype and phenotype of an individual is detected by the olfactory system, …


To analyze the real-time status of the pumping unit by virtue of its motor electrical information, accurate data analysis was generally required, coupled with a higher sampling frequency. This leads to a higher demand of the hardware and software configuration, especially for on-line analysis. Continuous high-speed sampling brings a large number of data-processing tasks, which makes the computer¿s resources lacked. By selecting appropriate schemes of intermittent high-speed data acquisition with an eye to the actual signal characteristics, the awkward situation maybe changed. Considering the problem of data-processing during data acquisition, one fitting-first HHT signals splitting method is proposed. It can provide a more feasible idea to improve the analysis precision of the motor electrical information.


Background: A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use.


What is International History? P.Finney Diplomacy and Decision-Makers T.Otte Economics B.Cumings Strategy and Warfare J.Ferris Ideology N.Gould-Davies Intelligence P.Jackson & L.Scott Propaganda, Communications and Opinion S.Carruthers Non-State Actors J.Suri Imperialism and Post-Colonialism M.Bradley Culture A.Rotter Gender G.Sluga Systems and IR Models C.Elman & M.F.Elman Global History A.Iriye Index


The receiving antenna effective temperature which is caused by the microwave noise sources of the inverse radiation are simulated in CST based on FIT(finite integration technique).According to the simplified model,the effect of the noise temperature,the calibration metal shield and the location of the receiving antenna are analyzed in detail.The calibration source of the microwave radiometer is mostly made by RAM(Radio Absorb Material) with high RL(Return Loss).Under this condition,the received brightness temperature is composed of two parts.One is from calibration source which is reflected by metal shield,the other is from inverse radiation thermal noise which is penetrated antenna aperture and reflected by the calibration source then received by the antenna.The coherent addition on the inverse radiation thermal noise which is directly reflected by the receiving antenna and reflected by the calibration source is considered in this simplified model.However,the effective of the metal shield and the coupling between the shield and the antenna are considered moreover in FIT.According this simulation,about the 1K antenna temperature is attributed to the inverse radiation thermal noise temperature 400 K.


This Report is the second part of a project that aimed to explore the feasibility of a restorative justice service in the context of work-related deaths in Victoria. It presents the responses received from interviewees representing key stakeholder groups, and makes a set of recommendations, based on the findings of this consultation process.


After showing how the UPQC is able to-compensate for network voltage variations through different operating strategies, one such strategy is proposed whose aim is to limit the total losses of the device. An estimate was made of the extent of the losses of converters as a function of the DC section voltage and of the maximum injectable voltage from the injection transformer and, subsequently, with reference to a specific case, the optimal values for the design of the device are defined. A procedure is proposed, based on simulation of the behaviour of converters, in order to calculate the operating losses of inverters controlled in accordance with the two different PWM techniques used in controlling valves of the device in question.


We discuss the analysis of real and simulated line spectra using a genetic forward modelling technique. We show that this Genetic Algorithm (GA) based tech- nique experiences none of the user bias or systematic prob- lems that arise when faced with poorly sampled or noisy data. An important feature of this technique is the ease with which rigid a priori constraints can be applied to the data. These constraints make the GA decomposition much more accurate and stable, especially at the limit of instrumental resolution, than decomposition algorithms commonly in use.


Background The CHA2DS2-VASc score has been associated with the prognosis of cardiovascular diseases. This study aimed to explore the association between the CHA2DS2-VASc score and all-cause mortality in coronary care unit (CCU) patients. Methods The study was based on the Medical Information Mart for Intensive Care (MIMIC) III database. CCU patients were divided into two groups according to CHA2DS2-VASc score: 0-3 (low risk),4-9 (intermediate and high risk). The primary outcome was 30-day mortality, and the secondary endpoints included in-hospital, 1-year, and 5-year mortality. Propensity score matching (PSM) and sensitivity analyzes for the confounders were also performed. The restricted cubic splines flexibility model was used to demonstrate the relation between red blood cell volume distribution width (RDW), blood urea nitrogen (BUN), platelet, white blood cell (WBC), hemoglobin, phosphorus, glucose, potassium, sodium and 30-day mortality in the 0-3 score versus the 4-9 score groups after PSM. Results Among 4491 eligible patients, 988 patients with low CHA2DS2-VASc scores and 988 patients with intermediate and high CHA2DS2-VASc scores had similar propensity scores and were included in the analyzes. In the survival analysis, the patients with intermediate and high CHA2DS2-VASc scores were associated with higher 30-day mortality [hazard ratio (HR): 1.11; 95% confidence interval (CI), 1.02–1.20, P = .014], 1-year mortality [HR: 1.13; 95%CI, 1.06–1.19, P < .001], and 5-year mortality [HR: 1.13; 95%CI, 1.07–1.18, P < .001]. The interaction for 30-day mortality among subgroups was not significant between the 0-3 score versus the 4-9 score groups. The restricted cubic splines for 30-day mortality demonstrated an L-shaped trajectory for platelets and hemoglobin, a J-shaped trajectory for WBC, glucose and potassium, and a U-shaped trajectory for sodium, respectively (all nonlinear P <.001). Conclusions A high CHA2DS2-VASc score was an independent risk for 30-day, 1-year, and 5-year mortality for CCU patients.


Objective To investigate the homology of Ku80 gene in CNE, SPC-A1 and MCF-7 cell lines and discuss the relationship between mutations of this gene and the result of radiotherapy and chemotherapy for tumor cells. Methods Polymerase chain response and cloning and sequencing technique were to determine the sequence of Ku80 gene related with repair of DNA lesions in tumor cells, then their conservative changes, modulated and compared changes of the hydrophicity-hydrophobicity of that gene productions were analyzed. Results In CNE, SPG-A1 and MCF-7 cell lines, the homology of Ku80 gene were 99.95%, 99.5% and 99.7%, respectively, including transversion and transition, parts of which leading to after amino-acid with others and change the hydrophicity-hydrophobicity of these products. Mutations in SPC-A1 cell resulted in 150aa Ile→Val, 470aa Asp→Gly, 553aa Phe→Ile alterations and 570aa Gln→0 deletion and in MCF-7 cell, 209aa Lys→Glu, 231aa Leu→Arg and 297aa→Ser alterations, but this production in CNE cell was high-conservation. Conclusions The conservations of encoding regions of Ku80 gene in SPC-A1 and MCF-7 cell lines are lower than that in CNE cell line. Therefore, mutations may enhance both activity of reproductions and ability of repairing double strand breaks, and this is related to the outcome of radiotherapy and chemotherapy for human tumor.


Madelung deformity of the wrist is a rare disorder. This often presents with a short forearm. This entity is also known as mesomelic dwarfism of Leri and Weill. Female preponderance is noted and is autosomal dominant. This may be bilateral in 50-66% of patients. Clinical diagnosis is often suggested but radiological confirmation is essential. Pseudo Madelung deformity simulates Madelung deformity except in the former there is negative ulnar variance with the distal articular surface of the ulna articulating with the medial cortex of the distal radial metaphysis. It also includes 'reverse Madelung deformity'. Three major causes of deformity exist: 1. Idiopathic, 2. Hereditary, 3. Acquired. Radiologically, shortening and bowing of radius is noted with dysgenesis of the distal radial epiphysis. Subluxation of the distal ulna is noted as well as dislocation at the elbow. Surgical correction is the only treatment with genetic consultation to the parents.


The difficulties in relating any diffraction theory to the defect structure of 'real crystals' used in crystallography are discussed qualitatively and it is shown that most of these problems become less severe in structure factor measurements by means of γ-ray diffractometry. Probably more direct information on the defect structure of the samples used in accurate diffraction experiments is needed in order to improve the situation. At present and probably for the near future it seems best to design experiments where extinction is only of the order of 10% or less.


A brief introduction of the historical development and the basic physical conditions of the hit theory, which gives new ways in the field of the analysis of the radiation effect and the metabolism of the cells is presented. The extension of the hit theory by means of reaction kinetics is discussed together along with tissue respiration. The treatment of time dependence as a model of biological recovery is introduced by the example of luminating bacteria. Some new results of studies about radio-chemical separation and combination processes of amino acids and electron resonance spectra following x-irradiation of fibro-proteins are presented. Most of the experiments mentioned were performed in the Max-Planck-Institute for Biophysics. (auth)


The complex production of translation and editorial intermediation is a timeless, often contentious issue. In the seventeenth century, Abraham Cowley and John Dryden dominated a debate that centred on fidelity to authorial copy. The widowed, self-supporting Aphra Behn, who translated from French in the late seventeenth century to earn an income, acknowledged this debate and indicated her preference for Dryden's translation practice of latitude in her epistolary dedication in the preliminary matter of Agnes de Castro: or, The Force of Generous Love (1688), which was originally written by Jean-Baptiste de Brilhac and entitled Agn es de Castro, Nouvelle Portugaise (1688). Behn wrote: ' 'Twas a Lady that writ the Original, and, I hope, I have not taken off from the Lustre of her admirable Piece by putting it into our Language '. Behn's latitude respected authorial intention but adapted the text when literal translation proved difficult. This paper dips below the discursive surface to provide a new way of analysing Behn's work. Comparing de Brilhac's original with Behn's translation reveals the latter's editorial intermediation. Behn used stagecraft techniques to create the narrative scene, paratextual asides to establish her authorial voice and editorial intermediation, and editorial techniques such as italicisation and capitalisation to further this intermediation and transmit meaning. Admittedly, Behn's practice often deviated from theory; nevertheless, such analysis reveals her editorial humanity.


ABSTRACT Collaborative skills that promote cross-functional dynamics, boundary spanning, and inter-firm cooperation are essential to every marketing manager. Most courses in the business curricula do not address the development of relational skills and competencies that support the ability to cooperate and reconcile diverse interests and objectives as needed in real world practice. I propose that we revise the fundamentals of our educational models to support the development of collaborative, cooperative and relational competencies in our business graduates. A "values" driven perspective is a must. It entails understanding, examining, reflecting, externalizing, discovering, accepting and challenging about our past experiences and beliefs as we refresh our perspective about things, people, situations, and options. New dimensions a business curricula that sustains a "values" driven perspective must include are: (1) Design curriculum from a systems thinking perspective, (2) Develop leadership potential and management capabilities, (3) Nurture and rehearse the use of different types of intelligences, (4) Foster deep approaches to learning when validating educational goals and academic achievement, and (5) Incorporate value driven decision-making and a sense of spirituality.


Objectives. To improve the outcomes of surgical treatment in patients with chronic posttraumatic arteriovenous vascular lesions (PAVL) on the basis of etiology and pathogenesis of the condition studying. Methods. 18 patients with PAVL were examined for the period from 2005 to 2009; 16 of them were males, 2 females; aged 25-59 years, 50% of the subjects were aged 25-40 years. The systemic hemodynamic changes according to echocardiography data before and after surgery were analyzed in 2 patients with PAVL of the femoral, posterior tibial vessels. Results. Mainly the damage of the lower extremities arteries (in 10 patients) were observed; 8 of them (66, 7%) needed reoperation, the duration of disease ranged from 3 months to 36 years. In this group ligation of the arteriovenous fistula was conducted in 2 patients, end-to-end arterial anastomosis in 1, lateral suture of artery in 1 patient, artery replacement with explants in 3; endovascular embolization in 1, stent-grafting of arteriovenous arteriovenous fistula with following surgical removal of pseudoaneurysm 1. Conclusions. The outcome of surgical treatment depends on the timeliness of special surgery done. Radical reconstructive surgery in patients with PAVL contributes to normalization of the general hemodynamic in early postoperative period. Combined use of surgical and endovascular methods allow decreasing considerably the intraoperative hemorrhage risk and surgical trauma in patients with chronic PAVL.


Objective To evaluate the safety and immunogenicity of domestic split influenza virus vaccine which advanced in 2007 by Shanghai Institute of Biological Products. Methods A random study was carried out in Sheyang County,Jiangsu Province and 500 subjects were selected. Results After immunization,the systemic and local reaction rates of domestic split influenza vaccine were 1.5% and 4.67%,respectively. The seroconversion rates of antibodies HI titers of H1N1,H3N2,and B were 99.13%,99.13%,and 100%,respectively. Antibodies HI titers rose four-fold,which were more than 78% in all groups except the group aged between 13 and 17 years of H3N2 (52.83%). The HI geometric mean titers (GMT) were all increased 3.9 folds in all groups. Conclusions Clinical trial indicates that the safety of split influenza virus vaccine has reached a satisfactory level.


Prior to the 1860s, midwives were the primary birth attendants in much of North America and Europe. With the ascendance oftechnology and the professionalization of modern medicine, midwives were removed from the mainstream and subject to prosecution for practicing medicine without a license. By the 1950s, midwifery had all but disappeared in Ontario. In the 1970s, the practise of midwifery began to emerge again as consumer demand increased drarnatically (see Bourgeault; Bourgeault, Benoit and Davis-Floyd). Influenced by the feminist movement, calling attention to "colonized wombs" and the marginalization of female professions, the new consumers of midwifery services believed that pregnancyand birth were normal, healthy family events and that pregnant women themselves should be the primary decision makers about the health care they receive (Pate1 and AlJazairi 51). During this time, midwifery practise enjoyed an alegal status as authorities aid little attention to the growing movement.' By the 1980s, midwifery could no longer be ignored. Two factors led to discussions of public provision. First, the death of a Toronto infant less than 48 hours after a midwife-attended birth spawned a flurry of attention to the practise. Second, a burgeoning crisis in obstetric care was becoming increasingly apparent. The nature of the crisis was twofold. First, fewer physicians were available to deliver babies. On the one hand, the number of obstetricians was declining rapidly with retirements and low enrolment rates. O n the other hand, fewer family physicians were willing to delivery babies (see Kaczorowski and Levitt). Second, spiralling healthcare costs were becoming a key concern for policy makers (see York; Rachlis and Kushner). Vicki Van Wagner notes,


arthropathy than the children, which may be another reason for their lower response. The bleeding response was rated as good in 71% of patients with mild bleeds and in 42% of those with moderate bleeds. Overall, in 97% of bleeding episodes the event stopped with only two doses of rFVIIa (average 1.5 doses). In the 29 joint bleeds, pain and tenderness disappeared and joint mobility improved after the first dose of rFVIIa in 18 cases (62%). The remaining haemarthroses responded to a second dose. In all three reported haematomas, the pain disappeared and haematoma size diminished after two doses of rFVIIa. It was noted that the response to rFVIIa varied in the three patients with oral bleeding. In one case, arrest of bleeding was achieved with the first dose of rFVIIa, whereas a second dose of rFVIIa was required for the second case, and the remaining patient started to re-bleed within 24 h, despite attaining full haemostasis initially. No adverse events were reported during the administration of rFVIIa in this patient cohort. The recent literature contains a number of reports of the use of a higher and single dose of rFVIIa to achieve bleeding control in haemophilia patients with inhibitors. Overall, these studies demonstrate that a single dose of rFVIIa 270 lg kg optimizes on-demand treatment by offering the same level of efficacy and safety as dosing schedules of rFVIIa 90 lg kg given every 2–3 h [4,5]. The results of this study support the view that a single high dose of rFVIIa offers a viable and effective alternative to standard dosing without altering the safety profile. Although this was a small study which used single doses of rFVIIa that are lower than those recently shown to be both effective and well tolerated by adults and children with haemophilia with inhibitors, it highlights the importance of optimizing the dose regimen according to local resources and patient characteristics, such as age, with the possibility of reducing the cost of the treatment.


Following the Mexican victory at Puebla on May 5, 1862, Mexicans in California formed patriotic assemblies, juntas patrioticas , to provide support to Mexico9s defense against the French intervention. Between 1863 and 1866, eight women9s organizations, juntas patrioticas de senoras , were formed. Their leadership, rhetoric, fund-raising, and extension to other causes indicate that Latinas in California were significantly informed, politicized, and independent.


The emotionally shattering events of September 11, the human tragedies of war, the race for the first human clone, the environment, the teaching of homosexuality in the school's sexual health education curriculum, ......the list of potential controversial issues to be explored in our classrooms can go on. The issue of whether schools should include controversial curriculum content has been the centre of much dissension and has raised many questions; Should schools be offering politically oriented content in its curriculum? Should schools be responding to wider societal issues? How should teachers handle discussions about controversial issues? What is the teachers' role in the classroom? This paper explores some of the debates surrounding the nature and place of controversial issues in the school curriculum. It opens the terrain for discussing the relevance and important contribution controversial issues can have to student learning. In support of the inclusion of controversy in the school curriculum, this paper presents ways of exploring and handling controversial issues through English Literature studies. Essentially this paper is a provocation which aims to challenge the increasing attitude of dissension towards controversy in schools and present constructive solutions. Introduction We have reached an era in schools in which an increasingly number of societal and world events are exerting a stronger influence on schools and their curriculum decision-making. Textbooks are no longer the primary resource in the classroom and the teacher's role is constantly being redefined. Classrooms have become places where teachers are required to deal, not only with matters of fact, but also with a wide range of student opinions, attitudes, values and beliefs. Increasingly, teachers have also had to deal with morality and ethical issues in class, conflicting definitions, public debate and action (Brinkley, 1999). Dealing effectively with the changing social forces has represented a dramatic shift in education with far-reaching implications. The most obvious has been the cause of an 'overcrowded curriculum' (McGee, 1997) or what William Doll (1996: 125-126) refers to as the 'curriculum bulge': In an era in which curriculum, particularly in the public schools, is already overloaded and in which thorough teaching of fundamental subject matter has been a priority, new demands for addition of subjects are cropping up everywhere. Today society expects that schools will teach AIDS prevention, improve the quality of sex education, warn against unwise use of drugs and alcohol, counsel against suicide, control violent behaviour and on and on. The consequence is a bulge in the curriculum that makes the responsibilities of teachers and administrators so heavy that the fundamental original work of the schools is done poorly.


This text will introduce the transformation of the frequency-speed control system for the grain slag dehydrator in the NO.3 blast furnace.The accessorial dynamic braking unit successfully prevented the frequent-happened dc-bus overvoltage fault and kept the stability of the system.


In real decision-making system, people often face huge amounts of data. So knowledge reduction is important. There are a lot of methods to computing the minimal reducts in complete information systems. But for incomplete information systems, the research of this aspect is few and difficult. Incomplete data sets may be transformed into complete data sets by similarity measures or by removing objects with unknown values before handling with them. But it is only by what to be supposed, and may not accord with the fact. So it is necessary to find reducts directly from incomplete data sets without guessing unknown attribute values. A theorem is proved on the basis of defined binary matrix and asymmetry relation, and a genetic algorithm based on this theorem is proposed for finding the minimal reducts from incomplete information systems. The experimental studies indicate that the genetic algorithm have good performance.


The invention belongs to the technical field of a power system, and particularly discloses a method for online measurement of short-circuit loss and open-circuit loss of a transformer. The method is based on the measurement principle that firstly short-circuit impedance of the transformer is calculated by utilizing the voltage and the current of the primary side and secondary side of the transformer, and then the short-circuit loss and open-circuit loss is calculated by utilizing the short-circuit impedance. According the property that the primary side voltage during normal operation of the transformer almost does not change with loads, an ideal AC constant-voltage source is used to substitute the primary side voltage of the transformer. Then a data collection device is adopted to collect a primary side current signal and secondary side voltage and current signals of the transformer; and the collected voltage and current signals as well as the constant-voltage source signals are processed by certain numerical calculation, and linear fitting is used to achieve the online short-circuit impedance measurement. Finally, the short-circuit loss and open-circuit loss of the transformer are calculated by utilizing the measured short-circuit impedance. The measurement method can save a great amount of manpower and material resources, and does not affect the continuity of power supply.


Due to overshadow and channel fading, many mobile users are unable to receive the signal transmitted from satellite directly. Hence, some relay stations should be set to help this type of users to receive signals reliably. In this paper, we present a novel cognitive hybrid satellite-terrestrial model, where two cognitive relays forward their received signal for a mobile user successively. Furthermore, we address its achievable rate maximization. We first convert the co-channel interference threshold into transmit power constraints, and then formulate the maximization of the achievable rate as an optimization problem. Based on Karush–Kuhn–Tucker conditions, the optimization problem is decomposed into four cases, each of which is solved in closed form. Simulation study with different system settings is presented, and the efficiency of the proposed power allocation scheme is shown.


As shown in the geological map in the Japanese text the Tetori series in the surveyed area is faulted and thiust at some places, and intruded by granitic rocks at others., Its base is unknown because of the igneous intrusion into the basal part., The series may be divisible into six formations in descending order as follows : f) Ogamigo upper Cyrena and Plant bearing formation e) Okurodani sandstone and conglomerate formation d) Otaniyama upper Perisphinctes bearing formation c) Mitarashi middle Cyrena and Plant bearing formation b) Nonomata lower Perisphinctes bearing formation a) Ushimaru lower Cyrena and Plant bearing formation The occurrences of Perisphinctids and other marine shells in the two formations are discoveries made by the present research., These marine formations alternate with the non-marine ones and the latter yield plant fossils., Formarly OISHI claimed that the plant beds indicate one definite horizon in the Tetori series, but in fact they are distributed in various horizons from top to base as KOBAYASHI has already pointed out., As the opinion that the Jurassic period was a time of tranquility insofar as volcanism is concerned has been current among the Japanese geologists, the find of acidic tufflayers in the Ushimaru and Mitarashi formations are facts hitherto unknown.,


Issues relevant to the current management of female infertility include the aging female infertile population and the obesity epidemic. Diagnosis is straightforward when causes are severe and laparoscopy is still the preferred method for assessing for tubal factor infertility and endometriosis. Laparoscopy can be timed to take advantage of the spontaneous pregnancy rate that exists mainly in unexplained infertility. IVF remains the dominant treatment, although traditional measures still have a major role. Internationally, IVF opportunities are limited in view of cost. The New Zealand system offers a prioritization system that enables public access to IVF for couples most in need and for those most likely to benefit.


Localized electronic charges in disordered solids can be described in terms of ions. The transfer of charge to and from electrodes corresponds then, to the oxidation/ reduction of molecular species. The study of these charge injecting redox processes forms a fundamental and growing segment of electrochemical research. The theoretical bases for these studies are deceptively concise and are briefly reviewed. The experimental predictions resulting from these foundations focus on the current-voltage relationships and on the frequency/time dependence of the interfacial impedance. The bulk of the substantiating evidence comes from the redox of active species in solution. New theoretical and experimental results relating to active species which are rigidly anchored to the electrode are presented. These results are compared to unpublished data on the electrode/organic photoconductor interface.


In this paper, a novel non-uniform stretching method of linear sparse array antenna design is proposed. This method is developed by applying new approach of inter-element spacing stretching strategy based on Chebyshev polynomial technique. The performance of proposed method is compared to full array antenna configuration with half-wavelength spacing. The simulation result shown the stretching-Chebyshev method has improved sidelobes level (SLL) compared to full array configuration with significant reduced number of array elements.


HE SERINE PROTEASE thrombin interacts with a T variety of substrates and as a consequence is involved in a number of physiologic processes. Fibrinogen is a particularly interesting substrate of thrombin for a number of reasons. First, thrombin cleaves not just one but four peptide bonds in fibrinogen, apparently in four successive steps. As a result ofthese proteolytic cleavages, the soluble fibrinogen molecules are converted into an insoluble fibrous polymer. In addition, the affinity of the enzyme for the final product, fibrin, is similar to that for the substrate, fibrinogen. Active thrombin is thus bound by the fibrin clot in a form largely resistant to inactivation by thrombin inhibitors, a situation that has important clinical consequences and complicates clinical anticoagulant therapy. This review focuses on the specific sequences of fibrinogen and fibrin that interact with thrombin. As illustrated in recent x-ray crystal structures of thrombin, the thrombin active site can be considered as two separate domains: a catalytic site that includes the Asp-His-Ser catalytic residues, the specificity pocket and an apolar pocket; and an extended fibrinogen recognition site (FRS). '3' The fibrin(ogen) regions responsible for binding to the catalytic site and the FRS will be examined and the properties of fibrin-bound thrombin discussed.


The state of central sensitization induced by the intradermic injection of capsaicin leads to structured (non‐random) changes in functional connectivity between dorsal horn neuronal populations distributed along the spinal lumbar segments in anaesthetized cats. The capsaicin‐induced changes in neuronal connectivity and the concurrent increase in secondary hyperalgesia are transiently reversed by the systemic administration of small doses of lidocaine, a clinically effective procedure to treat neuropathic pain. The effects of both capsaicin and lidocaine are greatly attenuated in spinalized preparations, showing that supraspinal influences play a significant role in the shaping of nociceptive‐induced changes in dorsal horn functional neuronal connectivity. We conclude that changes in functional connectivity between segmental populations of dorsal horn neurones induced by capsaicin and lidocaine result from a cooperative adaptive interaction between supraspinal and spinal neuronal networks, a process that may have a relevant role in the pathogenesis of chronic pain and analgesia.


Abstract: Can a library support an overseas program with a full-time librarian position? Can this position provide distant services successfully through e-learning techniques, social media and othe...


Shock wave propagation in a multiphase suspension is studied experimentally. Particle suspensions are used as a means of obtaining a system in which there is limited initial interparticle contacts with a large degree of parametric variability. Suspensions were created in ethylene glycol at several volume fractions (41%, 48%, and 54%) of silicon carbide particles. Plate impact experiments are conducted to obtain the shock Hugoniots of the various suspensions at particle velocities in the range of 200–900 m/s. Transitions are shown to exist in the Us-up Hugoniots of the suspensions. In situ longitudinal and lateral stress measurements are made in the 48% suspension at two different impact velocities demonstrating a deviatoric stress component to the stress state in the suspension. The results are discussed in terms of the development of extensive interparticle contacts in a mechanism analogous to classical shear thickening in dense suspensions.


The current trial was conducted to determine the chemical composition, potential nutritive value and methane production of oak tree leaves and nuts used in small ruminant animals. The chemical composition, metabolisable energy (ME) and in vitro organic matter digestibility (IVOMD) of oak tree leaves was significantly different from that of oak nuts (P<0.001). Except for dry matter (DM) and ether extract (EE), the crude ash (CA), crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF) and condensed tannin (CT) contents of oak leaves were significantly higher than those of oak nuts. On the other hand, oil content of leaves and nuts were similar. Although CP, CA and CT contents of leaves were 9.17, 5.58 and 9.22% of DM respectively, NDF and ADF contents of leaves were 45.13 and 41.18% of DM respectively. Gas production, methane production, IVOMD and ME contents of oak nuts were significantly higher than those of leaves (P<0.001). The gas production, methane production, ME and IVOMD of leaves were 27.47, 3.14 ml, 6.65 MJ/kg DM and %47.05 of DM respectively whereas the gas production, methane production, ME and IVOMD of nuts were 66.44 ml, 11.64 ml, 12.45 MJ/kg DM and 77.40% of DM respectively. In conclusion, oak trees from Quercus coccifera will provide nut with quite digestible and high ME for small ruminant animals. Oak leaves from Quercus coccifera can be used to decrease the methane emission since it has a moderate methane reduction potential. However further investigations are required to determine methane reduction potential of oak leaves in vivo animal experiments.


In this study, to determine the effect of career counseling programs on career attitude maturity of dance students, career counseling programs were provided to students as a career research process which enables them to establish their own identities and self-esteem, and helps them better understand personality, career fit, capability, talent, potential and interest. Through this, the study aims to identify the effect the counseling has on the career attitude maturity of their approach to career, which is the capability to effectively select a career with due consideration given to her capability and reality, as well as the effect on the factors that consist the career attitude maturity of approach to career, which are decisivenes,s goal orientation, confidence, preparation, and independence. By examining career counseling services offered at universities and their effect on the career attitude maturity of students towards careers through this study, we can se ethe need for continuous development of systematic and concrete career counseling programs, and the need for training career masters who can run these programs effectively. It also aims to contribute to progress in dance education to help students realize their dreams and establish a framework to envision a more stable future.


A method is described for manufacturing a magnetic sensor module having magnetic sensor elements monolithically integrated at a semiconductor chip (110) which comprises an integrated circuit. The described method comprises providing a composite semiconductor arrangement (105) comprising (i) the semiconductor chip (110), (ii) contact elements (112) for the integrated circuit, which are formed on the semiconductor chip (110), and (iii) a dielectric layer (120) formed over the semiconductor chip (110) and over the contact elements (112); forming a magnetic sensor layer providing the material for the magnetic sensor elements monolithically over the dielectric layer (120); exposing the contact elements (112) by removing a part of the dielectric layer (120) which part is located above the contact elements (112); and forming an electric conductive protection layer over either the formed magnetic sensor layer or the exposed contact elements (112). It is further described a magnetic sensor module which is manufactured by the above described method.


Rationale: Despite the approval of antiangiogenic therapy for high grade glioma (HGG) patients, survival benefits are still limited. New treatment plans have always been developed to improve the survival. Patient concerns: A 26-year-old woman was admitted to our hospital for distending pain of head and eye. Diagnoses: Resonance imaging (MRI) revealed a large spherical heterogeneously enhancing, mixed cystic and solid mass in the right frontal region, and the midline shifted. Intervention: The patient received apatinib therapy for positive vascular endothelial growth factor. Outcomes: A partial response was observed after 4 weeks and remains sustained until now. Lessons: It suggests that apatinib might be a feasible option for the treatment in advanced HGG patients or patients with poor physical condition.


[Abstract] A particularly powerful culture method for the retina is the explant assay, which consists in culturing a small piece of retina on an organotypic filter. Retinal explants can be prepared any time between embryonic day 13 (E13) and postnatal day 4 (P4). Although retinal ganglion cells tend to degenerate shortly after they are generated in explants, and photoreceptor cells do not grow extended outer segments, the explants will develop very similarly to a retina in vivo and generate all the different retinal cell types that will migrate to the appropriate layer. The retinal explant culture assay is particularly useful in cases where a mouse mutant is embryonic lethal and its retinal development cannot be studied in vivo. Because retinal explants can be prepared from embryonic animals and electroporated or infected with viral vectors, it is also a useful approach for the study of gene function at embryonic stages. Here, we present a retinal explant culture method that we have used extensively in various publications (Kechad et al. 1. Animals We typically use retinas from albino Sprague Dawley rats or mice. Explants can be prepared from animals aged between embryonic day 12 to post-natal day 4.


Paine (1988) has written a persuasive evaluation of food web research. While his criticisms may be muted and focus on his work, they cast doubt on all papers analyzing previously published food web data, including many of our papers. The criticisms are telling because they are thoughtful and because Paine has written for so long and so effectively about food webs. Do Paine's comments indicate serious flaws in our studies of food webs? We feel the answer is yes: that analyses of previously published food webs have many limitations. However, neither of us has published a primary paper analyzing existing food web data since Pimm (1980a). What we have attempted to do since then is to address many of the issues Paine has raised. What we shall attempt here is, first, the placement of studies of existing food web data into a historical perspective. Then we shall review subsequent work, using both data collected expressly to test food web theories and experiments. Where we disagree with Paine is in our assessment of the health of food web research. Like the argument over whether a glass is half empty or half full, we agree with Paine's observations, but draw from them much more optimistic conclusions.


In the synchronous discrete model, the average memory capacity of bidirectional associative memories (BAMs) is compared with that of Hopfield memories, by means of a calculation of the percentage of good recall for 100 random BAMs of dimension 64×64, for different numbers of stored vectors. The memory capacity is found to be much smaller than the Kosko upper bound, which is the lesser of the two dimensions of the BAM. On the average, a 64×64 BAM has about 68 % of the capacity of the corresponding Hopfield memory with the same number of neurons. Orthonormal coding of the BAM Increases the effective storage capacity by only 25 %. The memory capacity limitations are due to spurious stable states, which arise in BAMs in much the same way as in Hopfleld memories. Occurrence of spurious stable states can be avoided by replacing the thresholding in the backlayer of the BAM by another nonlinear process, here called "Dominant Label Selection" (DLS). The simplest DLS is the winner-take-all net, which gives a fault-sensitive memory. Fault tolerance can be improved by the use of an orthogonal or unitary transformation. An optical application of the latter is a Fourier transform, which is implemented simply by a lens.


We studied Niveoscincus microlepidotus and N. metallicus in a habitat mosaic of alpine woodland, sub-alpine heath, and boulder fields in southern Tasmania. Ten habitat variables were used in a Principle Components Analysis (PCA) to provide a quantitative definition of mi- crohabitat preferences, based on the use of basking sites. Discriminant function analysis of the PCA axes clearly separated the species on the PC 1 axis, which was based on vegetation and substrate characteristics. Niveoscincus microlepidotus is found in open situations, represented predominantly by boulder fields. Niveoscincus metallicus is strongly associated with relatively high, dense vege- tation, thick litter layers, and damp soils, characteristics that are most commonly found in alpine woodland.


Herniae involving only a portion of the circumference of the bowel, and usually spoken of as Littre's herniae, are of two forms: One is a diverticular hernia, a hernia where a diverticulum of the bowel forms the contents of the hernial sac; the other is the partial intestinal wall hernia, partial, lateral enterocele (enterocele partialis seu lateralis seu hemiperipherica), where only a segment of the free margin of the bowel forms the contents of the hernial sac. Partial intestinal wall herniae occur in two forms: The acute partial enterocele, where the hernia is of sudden origin and without adhesions; the chronic partial enterocele, where the hernia is of slow origin and usually with adhesions; that the acute form occurs is denied. Clinical experience alone can refute this denial, and the material is not lacking that will constitute the necessary burden of proof to establish the fact that acute partial enterocele


To compare the performance of third‐trimester screening, based on estimated fetal weight centile (EFWc) vs a combined model including maternal baseline characteristics, fetoplacental ultrasound and maternal biochemical markers, for the prediction of small‐for‐gestational‐age (SGA) neonates and late‐onset fetal growth restriction (FGR).


The study was designed to evaluated exocrine pancreatic enzyme replacement therapy in hyperglycemic male rats induced by alloxan. A total of forty five adult male rats were use in this study, hyperglycemia was induce in thirty rats by single intraperitoneal (i.p) injection of Alloxan 100mg/kg/B.W. and the experimental (45) distributed into three groups: the first group (15 animals) administered distilled water orally service as control group. The second group hyperglycemic groups (15 animals) was treated with exocrine pancreatic enzyme(EPE).The third group hyperglycemic group non treated with exocrine pancreatic enzyme(NEPE). Blood samples were take in days 20,40,60 of experiment for measurement the following parameters: Serum some biochemical parameters, tissue pancreatic activity.
The results showed that tissue orally gavages exocrine pancreatic enzyme(EPE) caused a significant elevation in tissue amylase activity in all treated group as compared to the control group. and significant increase in tissue amylase and decrease lipase and protease in concentration in EPE treated group as compared to the non-treated (NEPE) group. Also serum insulin concentration significant decrease and glucose showed a significant increase in EPE and NEPE groups when compared with the control group in after 20,40 and 60 day of experiment. The serum albumin showed significant decrease in all EPE groups when contrasted with the control group. And also The results illustrated that significant decrease in albumin concentration in all NEPE as compared to the control group. The Serum protein concentration was significant decrease in EPE and NEPE groups as compared to the control group in all experimental day. The results showed significant increase in serum cholesterol and triglyceride in EPE as compared to the NEPE . The results showed that PEP rats caused a significant decrease in serum high density lipoprotein (HDL)concentration as compared to the control group and significant decrease in HDL concentration in NEPE as compared to the control group. results showed that doses rats caused a significant(P


In this paper we study classes of projective, injective and flat modules over Banach algebras and introduce a numerical invariant for these modules. In particular we consider when the inclusion from a uniform algebra to the algebra of continuous functions on its Shilov boundary is a flat homomorphism.


The real stability radii for perturbed linear differential difference equations of the retarded type with a single delay are investigated. We present the corresponding readily computable formulae with respect to an arbitrary stability region in the complex plane. The results are further extended to the case of linear differential difference systems with multiple delays.


A novel technique which combines a speech waveform encoding process with multi-level modulation to realise a robust, spectrally efficient land mobile radio channel is described. The speech coding method is based upon a variant of adaptive bit allocation sub-band coding in which samples of the most energetic of eleven sub-bands are transmitted as discrete, multi-level symbols, together with some binary and additional multi-level symbols representing the overheads needed for reconstruction. Using this method, excellent audio quality has been achieved at symbol rates lower than 3 kS/sec under both simulated and real land mobile channel conditions. Description of how the method was used to provide a 4:1 spectrum efficiency over a 25 kHz spaced radio channel using TDMA in conjunction with multi-level (constant envelope) FSK, or more than 10:1 using linear modulation, are presented. At 4:1 with FM, the speech quality under strong signal conditions is very similar to standard FM and the coverage about 3 dB better for the same channel power.


Extraction of waterline in tidal flat has been one of the main concerns in the remote sensing of coastal region. This study aimed to define the spectral characteristics of turbid water near the shoreline and to find the appropriate spectrum to delineate the waterline at the inter-tidal flat in the western coast of Korean Peninsula. Spectral reflectance curves were obtained by the field measurements under the diverse condition of water depth and turbidity at the study area in Kyong-gi Bay. Spectroscopy measurements showed that reflectances of the exposed mudflat, shallow turbid water, and normal coastal water were significantly different by wavelength. Shallow water near the waterline showed diverse conditions of turbidity. Spectral reflectance tends to increase as turbidity increases, particularly at the visible and near infrared spectrum. At the middle infrared wavelength, tidal water showed very little reflectance regardless of the turbidity and water depth and was easily distinguished from the exposed tidal flat. The exact waterline between exposed tidal fiat and seawater should be extracted from the image data obtained at the middle infrared wavelength.


The prevalence of hypertension has increased throughout the year. Hypertension spreads widely because of the lack of knowledge and a healthy lifestyle. People's lifestyle which is more practical has an impact on the implementation of inappropriate hypertension diets and triggers various diseases. Based on this phenomenon, it is necessary to increase public knowledge about hypertension diets. The purpose of this activity was to provide counseling about a low-salt diet as an effort to increase knowledge of hypertension patients. The method was done by giving counseling about low salt diet through lectures to 30 hypertension patients who were routinely monitored at the Panti Rahayu Clinic. The pre test showed that almost all of the hypertension patients (80%) were in the poor category of knowledge. The post test showed that after being given counseling the knowledge of hypertension patients increased almost half (46%) were in the good category. Knowledge of hypertension patients increased after getting information through counseling activities about a low salt diet. Suggestions for clinics are expected to hold regular and periodic health education or promotion programs to provide information so as to increase the knowledge of hypertension patients.


This article discussed the calculation of the curvilinear integrals with respect to arc length in a plane.Firstly,from the definition of curvilinear C about parity function to coordinate axis,the definition of curvilinear C about parity function to any straight line was deduced.Also,the integral formula of parity function on arc length of curve symmetric to coordinate axis was extended to arc length of curve of any straight line in a plane.Meanwhile,the demonstration of that extension was presented.Secondly,on the basis of this function,the calculation problem of the curvilinear integrals with respect to arc length of a function on a closed curve arc was discussed.It is obvious that this formula greatly simplified the calculation process and had excellent practical value.


This letter demonstrates a scheme to characterize very precisely the field-dependent permittivity of nonlinear ferroelectric films using inhomogeneously tuned coplanar transmission lines. For the characterization, tunable coplanar waveguides on a screen-printed Ba0.6Sr0.4TiO3 (BST) thick film are realized and measured at radiofrequencies to determine the geometry-dependent tunability of the capacitance per unit length C'. To characterize the nonlinear tunability of the BST-thick film, these C'-values are compared with capacitance values simulated by the finite-difference time-domain method. Avoiding numerical instabilities of the iterative extraction procedure, the convergence of the extracted tunability is validated by three distinct geometries on the same BST substrate. The extracted tunability of the BST-thick film is 67% for an electric field-strength of 20V/mum. The precise knowledge of the field-dependent permittivity enables a distinct tunability optimization of frequency-agile radio frequency devices based on nonlinear ferroelectric films


The utility model relates to a water closet and particularly relates to a water closet provided with an automatic siphon valve device. According to the technical scheme of the utility model, the water closet provided with the automatic siphon valve device comprises a body and a closet basin arranged in the body. The closet basin is communicated with a sewage discharge pipeline through a siphon connecting pipeline. A blowoff valve is arranged between the siphon connecting pipeline and the sewage discharge pipeline. The blowoff valve comprises a value body, wherein the axial two ends of the valve body are respectively and hermetically connected with the siphon connecting pipeline and the sewage discharge pipeline. The valve body is provided with a connecting cavity used for communicating the siphon connecting pipeline with the sewage discharge pipeline, and an overturn valve plate used for closing or opening the connecting cavity. an overturn valve plate locking piece capable of being unlatched under the impact of the hydraulic pressure, and a resetting piece used for resetting the overturn valve plate without the presence of the hydraulic pressure, are arranged between the valve body and the overturn valve plate. Due to the adoption of the above technical scheme of the utility model, the water closet with the automatic siphon valve device is capable of improving the siphon effect, saving the water, lowering the requirement on the water pressure, deodorizing and reducing the noise during usage.


This paper probes into the present situation and the problems existing in E-reading room of university library,and expounds some measures for strengthening the management of E-reading room.


An automated method for sea route design based on electronic chart is developed to improve the security and reliability of planned sea route. First, the obstacle projection matrix is built based on the environmental information provided by electronic chart. Then a basic path is built quickly by using the adjacent relation among girds. Finally, elastic algorithm was used to optimize the basic path. And the safe shortest route is generated. Results from experiments demonstrate that the proposed method has advantages such as stability and efficiency and can be applied to route plan in large sea area and complicated sea condition.


In UX designing, we sometimes propose a new concept product or service, focusing on user experience value. In this case, it is desirable to conduct concept evaluation at an early stage to confirm the direction of development. However, the method to reasonably conduct a concept test at a stage when the product or service is not concrete enough remains unclear. In this study, we analyzed the effect of results from the differences in the expressions of the following 3 concept sentences: (A) expression showing only the experience value; (B) expression with usage scene in addition to the experience value; and (C) expression with function in addition to the experience value. As a result, we found that A could reasonably evaluate "the degree of matching the needs" and "novelty", and that C could reasonably evaluate "sympathy". In this study, therefore, we suggest a two-stage concept test method in which we first present only the experience value to evaluate the degree of matching the needs and then present the usage scene to evaluate sympathy.


MOTIVATION AND OVERVIEW Formation estimation of a distributed spacecraft system requires data exchange between spacecraft via inter-spacecraft communication devices. When spacecraft sensor measurements are sampled and digitized, the corresponding measurement epochs are tagged. These streams of time-tagged data from formation members are collected and used in the formation estimator to reconstruct formation state variables [ 11. For example, the translational state propagation involves differencing and integrating inertial measurements obtained through inter-spacecraft communications. Since each spacecraft operates and processes data with independent internal clock, asynchronous clock error (i.e. epoch difference) between spacecraft causes the estimation error. Even if the transmitted data are broadcasted in regular time intervals and the data epoch is predicted based on the data reception time, complete elimination of clock errors is difficult. If the time errors are not properly compensated, the formation system will suffer performance


This paper analyzed the limitations of network attack classification research.Presented a classification system composed by four levels.The main structure contained attack view,defense view and third-party view.Proposed and compared three different methods to evaluate the results on the classification which took acceptability,completeness,exclusive,determinism and availability as the basic indexes.Described RDF used in the examples of the classification system.The result shows that this method is sound and effective for evaluation and visualization of attack classification research.


The invention provides a novel PVC (poly vinyl chloride)/CaCO3 composite material. According to the novel PVC/CaCO3 composite material, a twin-screw extruder is adopted for extruding and pelleting, an injection molding machine is used for injection molding, nano-calcium is used for filling, therefore, the stretching strength of the PVC can be increased by 19%, and the non-notch impact strength of the PVC can be increased over three times up to 40.05kJ/m2, and the notch impact strength of the PVC is increased by about 3 three times to reach 28.94kJ/m2; the composite material has the best compressive mechanical property, and the stretching strength, the impact strength and the bending strength of the composite material are relatively improved.


A disclosed sterilization composition containing cyazofamid and a strobilurin compound comprises a component A and a component B with a weight ratio of 1%-50%:1%-50%, wherein the active component A is cyazofamid, and the active component B is any one bactericides selected from azoxystrobin, kresoxim-methyl, ZJ0712 (2-[3-(2,5-diMethyl-phenoxymethyl)-phenyl]-3-methoxy-acrylic acid methyl ester), picoxystrobin and enestroburin. The composition provided by the invention is capable of controlling multiple crop diseases, has obvious synergic effect, is enlarged in sterilization spectrum, and has relatively high activity on downy mildew, peronophythora litchii Chen ex Ko et al., eqpidemic disease, anthracnose and powdery mildew; and the pesticide usage amount is reduced, the residual quantity of the pesticide on crops is reduced, and the environmental pollution is mitigated.


The following essay describes and compares Fisher's Randomization Test and Neyman's average treatment test, with the intention of concluding an easily understood blueprint for the comprehension of ...


We have utilized an acetylene gas sample to assess the performance of a newly constructed cavity ringdown laser absorption (CRDS) spectrometer at the Arkansas Center for Laser Applications and Science (ArCLAS). During this assessment process, four overtone combination bands were observed for the C2H2 species, three of which have not been previously reported in the literature. For two of these previously unreported bands, a total of 85 rovibrational transitions (over 40 in each band) have been assigned using ground state combination difference theory. The data have been fit to standard energy expressions, and a set of molecular constants for each overtone combination band have been obtained. Here we present a brief description of the ArCLAS CRDS instrument along with the complete rovibrational analysis of these two combination overtone bands. 2012 Elsevier Inc. All rights reserved.


Objectives To characterize the epidemiologic profiles of prediabetes mellitus (preDM), diabetes mellitus (DM), and hypertension (HTN) in Qataris using the nationally representative 2012 Qatar STEPwise Survey. Methods A secondary data analysis of a cross-sectional survey that included 2,497 Qatari nationals aged 18–64 years. Descriptive and analytical statistical analyses were conducted. Results Prevalence of preDM, DM, and HTN in Qataris aged 18–64 years was 11.9% (95% confidence interval [CI] 9.6%-14.7%), 10.4% (95% CI 8.4%-12.9%), and 32.9% (95% CI 30.4%-35.6%), respectively. Age was the common factor associated with the three conditions. Adjusted analyses showed that unhealthy diet (adjusted odds ratio (aOR) = 1.84, 95% CI 1.01–3.36) was significantly associated with preDM; that physical inactivity (aOR = 1.66, 95% CI 1.12–2.46), central obesity (aOR = 2.08, 95% CI 1.02–4.26), and HTN (aOR = 2.18, 95% CI 1.40–3.38) were significantly associated with DM; and that DM (aOR = 2.07, 95% CI 1.34–3.22) was significantly associated with HTN. Population attributable fraction of preDM associated with unhealthy diet was 7.7%; of DM associated with physical inactivity, central obesity, and HTN, respectively, was 14.9%, 39.8%, and 17.5%; and of HTN associated with DM was 3.0%. Conclusions One in five Qataris is living with either preDM or DM, and one in three is living with HTN, conditions that were found to be primarily driven by lifestyle factors. Prevention, control, and management of these conditions should be a national priority to reduce their disease burden and associated disease sequelae.


This thesis proposes an extended version of the Combinatory Categorial Grammar (CCG) formalism, with the following features: 1. grammars incorporate inheritance hierarchies of lexical types, defined over a simple, feature-based constraint language 2. CCG lexicons are, or at least can be, functions from forms to these lexical types This formalism, which I refer to as 'inheritance-driven' CCG (I-CCG), is conceptualised as a partially model-theoretic system, involving a distinction between category descriptions and their underlying category models, with these two notions being related by logical satisfaction. I argue that the I-CCG formalism retains all the advantages of both the core CCG framework and proposed generalisations involving such things as multiset categories, unary modalities or typed feature structures. In addition, I-CCG: 1. provides non-redundant lexicons for human languages 2. captures a range of well-known implicational word order universals in terms of an acquisition-based preference for shorter grammars This thesis proceeds as follows: Chapter 2 introduces the 'baseline' CCG formalism, which incorporates just the essential elements of category notation, without any of the proposed extensions. Chapter 3 reviews parts of the CCG literature dealing with linguistic competence in its most general sense, showing how the formalism predicts a number of language universals in terms of either its restricted generative capacity or the prioritisation of simpler lexicons. Chapter 4 analyses the first motivation for generalising the baseline category notation, demonstrating how certain fairly simple implicational word order universals are not formally predicted by baseline CCG, although they intuitively do involve considerations of grammatical economy. Chapter 5 examines the second motivation underlying many of the customised CCG category notations — to reduce lexical redundancy, thus allowing for the construction of lexicons which assign (each sense of) open class words and morphemes to no more than one lexical category, itself denoted by a non-composite lexical type.


The patterns of socio/political transformation that Iran went through in the 20 century generated episodes of great ideological divergence within Iran's shi'ite establishment. The current study seeks to shed light on an instance of textual exchange that took place in the earlier part of the century – in 1943 – but became the bedrock for subsequent discursive conflicts within shi'ism notably during and after the 1979 Islamic Revolution. Adopting the format of a dialogue and operating within the milieu of a shi'ite outlook, the authors of this exchange, Hakamizadeh and Khomeini, touched upon several social and political topics such as the God/human relation, the notion of Imamate, the institution of the clergy, the state, and the law. In this doctrinal dialogue, one writer, the excleric Hakamizadeh, set out to depict shi'ism as simply a persuasive system to deter the individual from harmful deeds. His critic, the cleric Khomeini, represents shi'ism as a divine regulatory system to codify the standard of not only ethics and manners but also the political


This work presents a new algorithm for improving the simulation accuracy of power supply induced jitter (PSIJ) in input/output buffer specification (IBIS) model. The improvement is realized by modifying the switching coefficient Ku and Kd as a function of both time and power rail voltage. The incorporation of time averaged effect of the power rail noise on buffer output switching edge during the time range of buffer propagation delay is the key element for the enhanced accuracy. In addition, implementation of the proposed algorithm in an open source spice simulator Ngspice is demonstrated. The accuracy of the proposed new algorithm is validated through transistor level circuit simulations.


Enforced retenion of mature eggs by Aedes aegypti (L.) tends to inhibit the initiatIOn of the subsequent vitellogenic cycle when these females take a 2nd blood meal. While normal blood-feeding occurred in these females, the time when maximum vitellogenic initiation occurred was distinctly delayed and depressed when compared to controls which had oviposited. Approximately 50% of the females which did not initiate vitellogenesis after the 2nd blood meal still developed their oocytes to a stage intermediate between the resting and mature stages. This may represent vitellogenesis, begun after blood feeding, but not completled because of hormone deficiency.


This paper presents the methods of compiling programs aimed at modernizing industrial enterprises of various purposes. These methods help to form the entire sum of all permissible alternative options of modernization programs at initial stages for their subsequent evaluation and comparison. The basis of the method is a ten-graph model that defines a number of options for implementing individual structural components of the modernization program, such as the range of products manufactured, the technological process of manufacturing primary components, the main equipment, the cutting tools and accessories, organization of the manufacturing process, enterprise staff, suppliers of materials and components, financing plans for the modernization program, and the parameters of external macro environment of the enterprise in question. A mathematical model used to form a multitude of alternative options of modernization programs, employing algorithms of searching into the graph depth and width, has been developed. The developed method may be employed to form options for the modernization of industrial enterprises of various purposes. Industrial testing of the developed method has demonstrated its efficiency and flexibility in solving various problems linked to modernization of industrial enterprises.


Wide bandgap semiconductors enable high voltage (10 kV and more) switches. As a consequence, new packaging solutions are required to prepare the ground for such devices. The metallized ceramic substrate is a well-known and established technology for voltages up to 3.3kV, but it exhibits some weaknesses at higher voltages: due to its manufacturing process, the profile of the metallization is sharp and induces a reinforcement of the electric field at the "triple point" area (where the ceramic, the conductor and the encapsulating material meet), which can lead to Partial Discharges (PD), eventually causing a failure of the module. In this paper, we present a new substrate structure, where the triple point is moved away to an area where the electric field is lower. In this structure, the ceramic is machined to form protrusions, and round-edge metallizations are brazed on top. The design of the substrate, based on finite-elements is described, and calculations show that a 1 mm-thick AlN layer should be sufficient to withstand 10 kV. The manufacturing process of this substrate is presented. The test results demonstrate the superiority of this new solution, with a partial discharge inception voltage increased by 38 %.


The Anglican Church has released a report into past cases of child sex abuse within the church in Australia. University of Sydney researchers examined 191 incidents involving 17 dioceses across the country between 1990 and 2008. The study shows boys aged between 10 and 15 were the most likely victims, while the average time it took for abuse to be reported to authorities was 23 years. The study was prepared by child sexual abuse experts, Emeritus Professor Kim Oates of the Medical Faculty of the University of Sydney and Professor Patrick Parkinson of the University of Sydney Faculty of Law.


Electrostatic doping is a promising method for separating the effects of carrier density and disorder in the cuprates. To this end, we have produced exfoliated micro-samples of underdoped Bi-2212 on SiO2/Si sub-strates. Using this method we reliably produce crystals on the order of hundreds of square microns and as thin as a few unit cells. We present the results of exten-sive atomic force, optical and polarized Raman microscopy studies of these samples. Taken together these results clearly demonstrate these thin crystals have the same properties as bulk Bi-2212.


Acylals (8) are produced by the reaction of benzaldehyde with methyl diphenylphosphinite (4a) and carboxylic acids. One diastereoisomer of (8) is formed almost exclusively under mild conditions; the reasons for this are discussed. α-(α-Acetoxybenzyloxy)benzyldiphenylphosphine oxide (8a) is relatively inert to methanol. Analogues of (8), the 3-acyloxy-1,3-diphenylpropylphosphine oxides (9), have been synthesised and used in assignment of structure to the acylals (8).


February 2017 • Volume 124 • Number 2 www.anesthesia-analgesia.org 375 Dural puncture epidural is a technique in which the dura is perforated with a spinal needle, but no intrathecal medication is given. In infographic, we describe a randomized controlled trial that compares dural puncture epidural technique to a combined spinal epidural and an epidural technique, comparing and contrasting efficacy of labor analgesia and side effect profile.1 RefeRence 1. Chau A, Bibbo C, Huang CC, Elterman KG, Capiello EC, Robinson JN, Tsen LC. Dural puncture epidural technique improves labor analgesia quality with fewer side effects compared with epidural and combined spinal epidural techniques: a randomized clinical trial. Anesth Analg. 2017;124:560–569.


Pulmonary artery banding (PAB) is a useful adjunct for surgeons palliating several congenital cardiac conditions such as multiple muscular ventricular septal defects (VSDs), VSD in the setting of congenital lesions being approached via a left thoracotomy, and other more complex congenital conditions. Whereas initial sizing technique has been explored by several groups, there comes a time that the PAB must be removed surgically even in the absence of requirements for additional procedures (eg, closure of a muscular VSD that was the original indication for PAB application). We present the use of a novel expanded poly-tetrafluoroethylene (ePTFE) graft (exGraft; PECA Labs) as the material for main PAB creation; this material is dilatable up to 250 % to 300 % of its original size without affecting physiologic microstructure; this allowed for the dilation of the main PAB and prevention of further surgery in a patient with coarctation of the aorta repaired via left thoracotomy and PAB placement for a VSD that subsequently closed. 1


This paper summarizes and analyzes the typical architecture and evolution of fault prediction and health management technology. We introduce and analyze fault detection, fault diagnosis, and fault prediction functions to explore the architecture of fault prediction and health management systems. This experiment studies the fault prediction method based on solder joint-built in self-test (SJ-BIST). According to the actual monitoring circuit experiments, we adjusted the temperature of the circuit board to 50℃, 100℃, and 150℃ for the circuit board heating treatment for 10 seconds, verified the effectiveness of the SJ-BIST method, and are in line with the law of linear change. The slope of the fitted curve is consistent with the analysis result.


The explosive growth of uploaded photos requires service providers to improve the overall efficiency for analyzing and manipulating uploaded photos. Seeing the needs, we investigate the feasibility to speed up photo-related analysis (e.g., face detection) by leveraging the observations from large-scale consumer photos. To deal with the huge computations of face detection on the large-scale photos, we aim to reduce search hypotheses (i.e., subwindows) for face detectors by thresholding (or ranking) on the confidence of hypothesis that indicates the possibility to be a face. Unlike the traditional sliding window which views all the hypotheses equally, prior knowledge of face sizes and locations in images is learned from the large-scale consumer photos, and used to model the confidence of each hypothesis. By thresholding on the ranked hypotheses, less likely hypotheses can be reduced for better efficiency. Our experiment demonstrates that 40% subwindows can be skipped while maintaining 95% face recall, compared to traditional sliding-window-based methods.


ABSTRACT This paper primarily covers the first phase of a project to demonstrate analytical methods in their ability to measure individual polynuclear aromatic hydrocarbons in typical petroleum oil...


The aim of this study was to test the effectiveness of the Sensibility Development Program against Cyberbullying in raising awareness around cyberbullying and reducing cyberbullying behaviors. The program specifically targeted adolescents who were at risk of exposure to cyberbullying behaviors. For this study, an experimental design with a control group was used (N = 18). The Cyberbullying Sensibility Scale (CBSS) was administered to the experimental and the control groups before and after the program. The experimental group also filled out the Cyberbullying Scale, which measured engagement with cyberbullying behaviors. Statistical analysis indicated that there was a significant difference between CBSS pre-and-post-test scores in the experimental group. No significant difference was found for the control group, suggesting that the program was effective in helping students develop a level of sensibility against cyberbullying. No significant difference was found between pre-and-post-tests with respect to students' engagement with cyberbullying behaviors. The implications for prevention and intervention programs were discussed.


BIM is not only a 3D model, it provides information about the physical and functional components of the structure to support its construction and management throughout its life cycle. VR is not only to provide immersive simulation, it can also be called an integrated collaborative design platform, which will completely change how architects use BIM Technology. The application of R technology in the field of architecture and BIM system will further visualize the causes and results of architectural design. Multi disciplines can also start to intervene from the beginning of design, integrate various factors in the design process for consideration, maximize the expression of design intent, and enable users to experience it personally.


The antenna chopper and data processing system of microwave spectroradiometer for atmospheric ozone monitoring at the frequency 110836 MHz are considered. It is realized fully digital real time postdetection signal processing at the sampling frequency up to 25 kHz for each of 32 spectroradiometer channels.


This study explores pre-service teachers' (referred to as student-teachers) notions of creativity in music, particularly in relation to the classroom. Seventeen student-teachers wishing to pursue a career in primary education were interviewed and completed questionnaires. In general terms, all participants talked about the high value of creative musical activities for primary age pupils as they recognized a wide range of benefits. However, the analysis revealed that some student-teachers held richer conceptions than others. Student-teachers holding richer conceptions: (a) provided more articulate and detailed answers, and were able to describe the creative process more accurately and comfortably; (b) had taught the lesson that they described and were more enthusiastic and keen to talk about it; and (c) tended to emphasize the learning that would take place during the creative process. These findings are discussed in terms of their practical educational implications in the primary music classroom and beyond.


Stabilization (control system design) is one of fundamental areas investigated in the system theory. In this paper is presented method based on metric equivalence. The special attention is devoted of the application this technique for design a controller law on two examples.


The sculpture from the 16th century of a naked woman on her deathbed, preserved at the church of Saint Denis in Amboise, is usually referred to in bibliography as "the drowned woman" and was attributedby local tradition to the Italian painter Primaticcio. This attribution has been challenged for a long time, but the circumstances surrounding the commission remained unknown. The history of this work, moved several times, was revealed by Alfred Gabeau at the end of the 19th century; it can now be completed and clarified by the study of documents and iconographic sources preserved in archives and libraries of France.The purpose of this article is to identify and to list the historical sources concerning this work, to take stock of its history and to place this funerary monument in its artistic context in order to better understand the circumstances of this important commission. The study confirms the identification of the recumbent effigy as a statue of Marie Gaudin, the widow of the rich financier Philibert Babou from Tours. Taking as an example the royal tombs at the basilica of Saint Denis, this commission demonstrates the practices and artistic strategies of the refined aristocracy of the Renaissance.


The Pherocon Ic trap captured the greatest number of Cydia caryana (Fitch) adult males and all trap designs appeared to represent population trends equally well. Pooled data from all trap height experiments indicate that traps placed 9.14 m above the orchard floor captured significantly more adult males than those placed at 4.57 m height. Horizontal placement of traps within the tree canopy indicated a significantly greater capture in the central portion of the canopy than at other locations. Correlations between the total capture of male adults and the rate of fruit infestation were not significant.


Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the PCSK9 gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals. Methods: We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR). Results: Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters. Conclusions: Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis.