There are two principal reasons for compacting highway subgrades and fills. One of these is to improve subgrade strength, thereby permit ting an economical pavement design to support the required wheel loads. The other purpose is to create a fill of low compressibility, thereby minimizing settlements of the roadway. Although high strength and low compressibility are always in the pavement designer's mind, it is seldom if ever that subgrade specifications are written directly around these two properties. Customary practice is to specify a certain density or a certain percentage of an arbitrary maximum density as a means of securing adequate compaction. This is done on the assumption that the sought-for strength and compressibility characteristics will be obtained if this minimum density is achieved. The validity of this assumption is open to question. The terms "inspection" and "control" are frequently grouped to gether when applied to those activities that are undertaken to insure that specifications are met on a soil compaction job. The two terms are not synonymous, of course. "Inspection" in this case tends to be asso ciated largely with the density tests that are performed after compaction is complete to determine whether the finished product meets specifica tions. "Control," on the other hand, includes a variety of efforts, not limited to soil tests, that are made while compaction is in progress to help bring about its efficient and successful completion. Adequate performance of inspection, in the limited sense just mentioned, requires mainly a knowledge and command of field testing techniques. The performance of control duties, on the other hand, requires not only a knowledge of field and laboratory testing techniques but also a capacity


Current state-of-the-art document classification methods based on attention mechanisms on document structures have been shown to perform well due to their ability to attend differentially to more and less important parts of the document when constructing the representation. While these models perform well on flat classification tasks, to our knowledge not much research has been done on hierarchical classification tasks. In this paper, we propose a few variations of the Hierarchical Attention Network (HAN) that directly incorporate the pre-defined hierarchical structure of the output label space into the network structure, via the use of hierarchical output layers representing different levels of the output label's hierarchy. We present an evaluation of this model using the task of classifying Shopify app descriptions to a hierarchically-structured app category labels, and we demonstrate that by incorporating hierarchical structure of the labels into the design of the network, the model was able to outperform the baseline by a substantial margin. Additionally, we compare the classification performance of all the proposed variations.


This study aims to determine what factors can affect the Quality of Information Technology Audit. In this paper will describe various studies related to IT Audit, Role of IT Audit, IT Audit Report content and IT Audit Quality. The results are known what factors can affect the Quality of IT Audit and the implications for knowing these factors


Disclosed is a method for processing a terminal trigger message, which comprises: a mobility management entity (MME) or serving GPRS support node (SGSN) removing a corresponding terminal trigger message after deactivating an idle-state signaling reduction (ISR) function. Also disclosed are a system for processing a terminal trigger message and a related network element. In the present invention, since the MME or SGSN can rapidly remove a corresponding terminal trigger message after deactivating the ISR function, the waste of network storage resources is avoided.


The first part of this contribution deals with the relationships between, physics and biology, and with contents of biophysical and biochemical research. In the second part, some biochemical problems of potential interest to the physicists are treated in more detail (energetic metabolisms, structure of globular proteins).


In this paper, a new method for eye gaze tracking is proposed under natural head movement. In this method, pixel-pattern-based texture feature (PPBTF) is proposed to calculate the infrared eye features according to the characteristic of the infrared eye, and a new binocular vision approach is adopted to detect the space coordinate of the eye. The combined features of space coordinates and PPBTF features of the eyes are fed into support vector regression (SVR) to match the gaze mapping function, in the hope of tracking gaze direction under natural head movement. The experimental results prove that the proposed method can determine the gaze direction accurately.


Large non-aldehydic 1H hyperfine couplings in the radical cations of four carbonyl compounds are assigned to long-range hyperfine interactions relayed through a trans(W-plan) arrangement of C–C and C–H σ bonds; for example, the two strongly coupled hydrogens in the cyclohexanone radical cation are identified by deuterium substitution as the 'δ' equatorial pair at C-3 and C-5 rather than the 'γ' equatorial pair at C-2 and C-6 assigned previously.


How do neuronal populations encode time-dependent stimuli in their population firing rate? To address this question, I consider the quasi-renewal equation and the event-based expansion, two theoretical approximations proposed recently, and test these against peri-stimulus time histograms from L2-3 pyramidal cells in vitro. Parameters are optimized by gradient descent to best match the firing rate output given the current input. The fitting method can estimate single-neuron parameters that are normally obtained either with intracellular recordings or with individual spike trains. I find that quasi-renewal theory predicts the adapting firing rate with good precision but not the event-based expansion. Quasi-renewal predictions are equal in quality with state-of-the-art spike timing prediction methods, and does so without resorting to the indiviual spike times or the membrane potential responses.


The gastro-omental flap consists of a patch taken from the greater curvature of the stomach and the bordering omentum. It is based on the right gastro epiploic vessels and is used as a free flap for intraoral reconstruction after resection of oral carcinoma. Twenty patients underwent gastro-omental flap. The operative technique is described. The evaluation consisted in questioning, chemism on the salivary flow and biopsies. There is no morbidity related with the donor site. The gastro-omental flap avoids post irradiation xerostomia. Oral irritation and bleeding of the flap may occur.


The invention provides a kind of dendrimer and a kind of organic light-emitting device comprising the organic layer with this dendrimer.


A digital twin is much as it sounds: a digital representation of a specific asset in the field, including current and past configuration states, considering serialized parts, software versions, options, and variants. Condition data is also represented including sensor readings, alerts, and operating environments. A digital twin has significant implications for service, operations, analysis, design, etc. especially when visualized as a Computer Aided Design (CAD)‐sourced graphic in 3D virtual or augmented reality. Using this immersive and real‐time information, engineers can inspect and verify the asset being serviced, designed or operated to get precise product information. However, the digital twin does not spring into life fully formed straight from the CAD model. It requires an informed system engineering approach to ensure that the integration between physical and digital is fit for purpose. Model‐Based Systems Engineering (MBSE) models can be used in conjunction with the digital twin to improve operational models, predict and analyze faults, perform best‐fit analysis and eliminate inappropriate system configurations, etc. This paper will look at various aspects of the digital twin and how it can be used in conjunction with MBSE.


Abstract Life in the short-term future will be revolutionized by the growing e ffect of multidisciplinary technology across all ...


Spectrophotometric distance moduli to ~16000 stars in the Milky Way southern hemisphere calculated from spectroscopic stellar parameters as determined by the RAVE spectroscopic survey using the 6dF instrument at the AAO.


[Extract] Barry asked me to provide you all with a personal viewpoint on the need for teachers to understand the important perspectives from which students of different backgrounds view their social world. As a Torres Strait Islander, and as a person indigenous to Australia, this no doubt points to my experience as a member of a group of colonized people on a very small island in a remote part of Australia who was educated formally through a system provided by those from the West. Although we are relatively small in numbers, we are many. Our experiences and perspectives come from many changing encounters with the outside world. So how do I do this? How can I put pen to paper without omitting somebody or something? I could perhaps universalize things into a science, say like in sociology or anthropology, and refer them to you in abstract terms according to the colonial order of things - but I'm not content with drawing analogies to already-formed concepts from the West.


ABSTRACT Objectives Using Terror Management Theory and Social Identity Theory as frameworks, we examined whether the relationship of aging anxiety to compassion for and emotional distance from older adults was mediated by ageist attitudes and whether an older adult's health condition moderated these relationships. Method Using an experimental design, 292 middle-aged adults (40–55 years) were assigned to read a description of an older adult with Alzheimer's Disease (AD), prostate cancer, or who was healthy. Results The relationship of aging anxiety to compassion was mediated by ageist attitudes in both the AD and prostate cancer conditions. More ageist attitudes related to less compassion more strongly for unhealthy older adult conditions than for the healthy older adult condition as well as for the AD condition compared to the cancer condition. Ageist attitudes related to more emotional distance from the older adult with AD than the older adult with cancer. Discussion Older adults with AD may evoke a stronger relationship of ageist attitudes with emotions toward older adults. These findings extend previous research by examining middle-aged participants, a population often serving as caregivers to their aging relatives.


The physical properties of four evaporitic rocks, anhydrite, gypsum, potash and rock salt, were investigated. Their respective specific gravities and dry densities show little variation and all four rock types have low porosity values. Anhydrite is by far the strongest material both in unconfined compression and in tension, followed by gypsum, potash and rock salt, in that order. The hardness values of these four rock types follow the same order as the strength values, to which they have a highly significant relationship. All four rock types exhibit some amount of plastic deformation prior to failure, anhydrite the least whilst rock salt shows the most. The value of Young's modulus tends to increase as the value of density, strength and hardness increases. Incremental creep tests indicate that rock salt suffers appreciable creep before failure, as does potash. Gypsum undergoes much more creep before failure than does anhydrite.


Successful Treatment of Severe Nummular Eczema of Fingers with Coix-seed Reactive Derivatives (CRD): A Case Report Nobutaka SUZUKI, Shintaro HASHIMOTO, Hoko KYO, Kazuo UEBABA 1 Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science 2 Daimyomachi skin Clinic 3 Urata Clinic, Hospy Medical Association 4 Teikyo Heisei University In this report, we presented the case of a 52-year-old woman who developed intractable nummular eczema of fingers for over 5 years. Coix-seed Reactive Derivatives(CRD) was administrated orally 2.2 g twice a day for 6 months. The lesions cured markedly within one month. Although CRD intake seemed to be effective in this case, further studies are needed to define the optimal dose of this food.


The heat equation in a solid body with radiation boundary conditions and periodic heating at the boundary- modeling a rotating asteroid- is shown to have a unique time-periodic solution and it is globally attracting.We find approximations to this solution for various cases relevant to the possible existence of ice the asteroid belt.


Presence of photonic band-gap (PBG) in an all-solid microstructured optical fiber (MOF), made of two fabrication compatible chalcogenide (Ch) glasses is theoretically investigated for potential application in the functional mid-infrared (IR) wavelength range. Cross-section of the MOF is formed by assuming periodically arranged wavelength scale circular air holes in a hexagonal pattern embedded in a uniform matrix. One type of Ch-glass is considered as the background material whereas another type of Ch-glass is assumed to fill the air holes. The relative index contrast between these two Ch-glasses is ~ 24%, for which PBG appears only for a suitable range of non-zero longitudinal wave vector. We have studied the scalability of this PBG by varying the lattice parameter of MOF and optimized the cross-section to attain the PBG at ~ 2 μm wavelength. Then by utilizing the thermo-optic properties of the glasses, the effect of external temperature (T) on the PBG is studied, and finally we have proposed a T-tunable wavelength filter/sensor at mid-IR wavelength with tuning sensitivity as high as ~ 140 pm/°C.


Heavy metal contents of farmland soils under permanent irrigation from polluted river water affect seriously the quality of farmland environment and food safety.In this paper,with Tianjin urban fringe zone(Wuqing County) as the case study,where the farmland was irrigated permanently using polluted river water,the spatial variation and distribution correlations of five heavy metals in farmland soils,including Cu,Zn,Pb,As and Hg are computed and analyzed based on geostatistics and ArcGIS techniques.The optimal spatial interpolation models of the soil heavy metals are discovered by means of the comparison analysis among the different interpolation methods,such as kriging and other certainty spatial interpolation methods.Then the distributions of the five soil heavy metal contents are mapped by using the optimal spatial interpolation models.The results show that the high values of the five heavy metal contents are located in the northern area of our research region,and Cu content in farmland soils decreases gradually with the irrigation distances along the sides of the Beijing sewage river.The contents of the soil Pb and Hg have high value centers in northern and southeastern area of this region.The high value centers of the soil Zn and As content are distributed just like some island shapes located in this region.Comparing with other towns,the administrative region of Dashahe town is the most serious polluted area in soil heavy metals,and here is the irrigated center using the polluted river water too.


An incalculable leaf classes are accessible all around towards oversee gigantic substance and the advancement of quick and compelling classification strategies has transformed into a region of effective look. Herbs and shrubs are essential for environment, precise recognition and characterization that winds up essential phenomena. Characterization methodology is conveyed out through number of sub systems. A recognizable proof on categorization subject is overseen by measuring information on one kind of classes. For this framework an initial database of petiole picture is made which includes pictures of a test petiole and proportionate herb data. Basic similar feature extractions are removed utilizing picture preparing strategies. The highlights must be steady so as to make the recognizable proof framework vigorous.Accordingly the herb/shrubs perceived utilizing deep learning techniques. Study of different kinds of leafs and their recognition is done in this paper.


The bibliography published in this book was first prepared in order to be distributed among the participants of the Symposium on Jacob of Edessa, held at Leiden University in April 1997. In most sections, bibliographical references are listed under three rubrics, marked by the letters [a], [b], and [c]. These rubrics should be understood as follows: [a] = editions and translations [b] = studies [c] = references (that is, books or articles in which Jacob?s works are discussed or referred to in a larger context). The book discusses Jacob?s biography as well as his position in early Islamic Edessa, and gives a full picture of the various aspects of Jacob of Edessa?s life and work as a scholar and clergyman.Keywords: early Islamic Edessa; Jacob of Edessa


The EU is actively pursuing Deep and Comprehensive Free Trade Agreements (DCFTAs) as part of its trade and aid relations with former colonies in North Africa. Utilizing the discourse of pro-poor business growth and win-win free trade, the EU insists that North African countries must acquiesce to DCFTA liberalization to achieve sustainable development. This article critiques the paternalism of EU actors amidst their focus on completing these controversial DCFTAs. Drawing upon Nkrumah's and Fanon's articulation of the concept of neocolonialism, it argues that the EU is cementing colonial-style patterns of production via iniquitous trade and aid arrangements. Moreover, the article illustrates that EU elites in their justification of the DCFTAs are replicating the colonial-era discourse surrounding Eurafrica and the alleged economic "complementarity" and inevitable "interdependence" of the European and African continents: an amnesiac Europe thus simultaneously draws upon European colonial imaginaries in the justification of neocolonial DCFTAs while downplaying, and forgetting, the regressive legacies of colonial trade relations. The article also demonstrates how certain North African campaigners are already drawing attention to the neocolonial contours of the DCFTAs in order to delegitimise these free trade vehicles vis-à-vis North African and European public opinion.


An all-optical device in which a nonlinear etalon is operated stably as a triode switch at a high on-off ratio is discussed. A nonlinear etalon is sandwiched between two quarter-pitch GRIN (graded index) lenses. Detuning is adjusted by using the position-to-angle conversion feature of the lens. Two orthogonally polarized beams are used to obtain a high on-off ratio ( approximately 10:1) even for a weak signal beam by completely separating a control beam from an output beam.<<ETX>>


This article is devoted to the issues of mutual influence of the processes of implementation of the concept of «green» economy and the index of human capital development in the world economy. The problems of the ecological crisis of 2021, the search for reduction of energy, material and other types of resources, taking into account the development of a «green» economy and environmental improvement, are outlined.The authors present the main approaches and directions of high–quality training of personnel and the search for ways of its development, based on the system of increasing human capital, identifying new directions for the use of existing resources by employees, including digital ones, adaptation to technology, taking into account the new «green» course of development of the world economy.


Cefpirome, which is a fourth-generation cephalosporin, was analyzed for the first time at a glassy carbon electrode using differential pulse voltammetry in this novel method. Different experimental conditions were optimized, such as pH and electrolyte type, to achieve a high peak current. Under the optimum conditions, the oxidation of cefpirome exhibited diffusion-controlled process depending on pH. Cefpirome was electrochemically determined at the linear range between 2-200 µM, and the detection limit was found as 0.167 µM in pH 4.7 acetate buffer solution. Analysis results showed that the proposed electrochemical method could be used for the determination of cefpirome in human urine samples. A linear relationship has been obtained in the concentration range of 2-10 µM. At the same time, the detection limit was found as 0.101 µM for cefpirome in human urine. Moreover, to check the selectivity of the proposed method, the effect of some interference species, including ascorbic acid, uric acid, dopamine, glucose, Na + , K + , Ca +2 , NO 3-, have also been investigated. As a result, a simple, sensitive, reproducible, no time-consuming, and more environmentally friendly method was developed when compared to the literature studies.


The demand for renewable energy sources has grown in recent years in function of the economic growth of the country and technological advance in the Brazilian agricultural sector contributed to increased electricity use in various agricultural activities. One of barriers that significantly decrease the income of the family farmers in Irrigated Perimeters is the electricity expense used to activate irrigation systems, which can reach up to 35% of total production costs. Based on this problem, the present study sought to assess the economic viability and estimate biogas production as an alternative source for electricity generation to be used in the irrigation district. The RETScreen® software was used for analysis of economic viability and production estimates, and the main indicators of economic viability were payback period and the internal rate of return. The study indicated that utilization of biogas generated from plant and animal residues is an economically viable source for electricity generation. However, the greater the quantity of plant matter and bovine dejections available, greater is electricity generation and consequently the generation system is more economically viability.


This work consists in a work about the internet of things, a new and promising area of
research, it starts with a brief history and evolution of the internet towards ubiquity.
This work also addresses the definition of the internet of things, its operation and
connectivity, as well as presents their most promising technologies, challenges and
future


Text Summarization is the process of creating a condensed form of text document which maintains significant information and general meaning of source text. Automatic text summarization becomes an important way of finding relevant information precisely in large text in a short time with little efforts. Text summarization approaches are classified into two categories: extractive and abstractive. This paper presents the comprehensive survey of both the approaches in text summarization.


Pulmonary veno-occlusive disease (PVOD) is an uncommon cause of pulmonary hypertension (PH) and has poor prognosis. There are several case reports of PVOD developing after hematopoietic stem cell transplantation, but there are only a few cases reported of development after chemotherapy. We present here a boy with Burkitt's lymphoma complicated with fatal PVOD, which developed after complete remission of lymphoma following six courses of aggressive combination chemotherapy.


The present invention relates to a device for remote handling machinery, consisting of: fixing adapted for fastening to the fingers (F, F a fastening strap which is connected to said bracket for holding it on the fingers (F, F a wireless transmitter / supply unit connected to said mount; and a control unit connected to said holder and consisting of a switch adapted to control the thumb of operator's hand to generate a request signal to movement of lifting machinery.


Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) are found in both pre-capillary pulmonary hypertension (PH), including pulmonary arterial hypertension, PH associated with hypoxia/lung disease and chronic thromboembolic pulmonary hypertension, and post-capillary PH associated with left heart disease. We asked the question of whether NT-proBNP concentrations differ among these PH subtypes.

 Based on right heart catheterization (RHC) data collected at our institution between Jan. 2019 and Dec. 2021, 146 patients were classified as no PH, pre-capillary PH, isolated post-capillary PH (iPC-PH) or combined pre- and post-capillary PH (cPC-PH) according to the 2022 ESC/ERS guidelines (GL). NT-proBNP values were compared across PH groups by Kruskal-Wallis test with Bonferroni correction. The characteristics of subjects with pre-capillary PH and NT-proBNP ≤ or >1.100 pg/mL, a cut-off for severity proposed by the 2022 GL, were compared by chi-square test, T-test, or Mann-Whitney test, as appropriate. We also applied the hemodynamic definitions of the 2018 6th World Symposium on PH (6WSPH) and of the 2015 GL, examined the differences in the distribution of PH groups with the McNemar test, and reassessed NT-proBNP concentrations.

 44 (30%) of patients did not have PH, 38 (26%) had pre-capillary PH, 18 (12%) had iPC-PH, and 46 (32%) had cPC-PH. NT-proBNP levels were progressively higher from pre-capillary PH to iPC-PH to cPC-PH (Figure). Interestingly, the 25th percentile of the cPC-PH group was 1.138 pg/mL, close to the 1.100 pg/mL cut-off. Compared with patients with pre-capillary PH and NT-proBNP ≤1.100 pg/mL, those with >1.100 pg/mL NT-proBNP had larger right ventricle basal diameter [50 (43-53) vs 43 (36-45) mm; p=0.02], lower TAPSE/sPAP ratio [0.21 (0.15-0.25) vs 0.35 (0.25-0.43), p=0.01], more often massive tricuspid regurgitation (83% vs 20%, p<0.001), higher pulmonary vascular resistance [9.5 (7.6-15.1) vs 5.7 (2.7-7.8) WU; p=0.004], and lower stroke volume index [28 (17-32) vs 36 (32-50) mL/m2; p=0.002]. The proportion of no PH decreased and the one of cPC-PH increased when the 6WSPH or the 2015 GL criteria were used (p for trend <0.001). Nonetheless, the trend of NT-proBNP remained similar to that observed with the 2022 GL definitions (Figure).

 A gradient of NT-proBNP exists across PH groups, with the highest values being in cPC-PH. The concentrations of NT-proBNP in severe pre-capillary PH overlap with those in cPC-PH, indirectly confirming the validity of this biomarker to discriminate the severity of pre-capillary PH.


We consider the problem of detecting visual evoked potentials (VEPs). A matched subspace filter (MSF) is applied to the detection of the VEP and is demonstrated to perform better than a number of other evoked potential (EP) detectors. Unlike single-harmonic detectors, the MSF detector is suitable for detecting multi-harmonic VEPs. Moreover, the MSF is optimal in the uniformly most powerful (UMP) sense for multi-harmonic signals with unknown noise variance.


This paper deals with the ordering and transportation of raw materials in a building and decorative plate enterprise. Quantitative analysis and analytic hierarchy process and TOPSIS algorithm are used to analyze the relevant materials and information of each supplier[1]. The grey prediction model are used to comprehensively evaluate each supplier and transshipment, and the most economical raw material ordering plan and the transport plan with the least loss are worked out[2]. Research on this issue can improve the efficiency and quality of raw material decision-making of domestic manufacturing enterprises, improve the increasingly fierce market competition environment faced by manufacturing enterprises, and further promote economic development. 1. Background At present, with the rapid development of various manufacturing enterprises and increasingly fierce market competition, the raw material cost, transportation cost, storage cost and other expenses of enterprises are constantly increasing, and the potential economic pressure is also increasing. How to reduce all kinds of costs, choose appropriate suppliers and changers, and develop the most economical raw material ordering scheme and the least loss of transport scheme under the premise of ensuring the normal production of enterprises is an important topic for the development of each enterprise. 2. Modeling and solving of problem 1 2.1 Model preparation The first problem to be solved is the evaluation problem. First of all, the characteristics of the importance of enterprise production are obtained from the enterprise order and supplier order. The supply characteristics of the supplier are evaluated comprehensively from four aspects: the production and supply capacity of the supplier, the cooperative relationship between the supplier and the enterprise, the reputation of the supplier and the enterprise's choice of the materials to be supplied, and a supplier supply characteristic index evaluation system is established. Then the analytic hierarchy Process (AHP) was used to assign weights to each indicator. Finally, TOPSIS method was used to quantify the importance of each supplier to ensure the enterprise's production, and the quantified value of each supplier's supply characteristics was ranked from superior to inferior, and Journal of Electronics and Information Science (2021) 6: 49-53 Clausius Scientific Press, Canada DOI: 10.23977/jeis.2021.060207 ISSN 2371-9524


Summary: It has been claimed that in patients with Bartter's syndrome, enhanced prostaglandin synthesis causes the blunted vasopressor response to angiotensin II. The present study was undertaken to test this hypothesis by administering indomethacin to a patient with Bartter's syndrome. Indomethacin corrected the subnormal pressor response to angiotensin II and lowered plasma renin activity from 115 to 15 ng/ml/hr. This effect was associated with renal sodium retention and a 7% increase in body weight. In contrast, when indomethacin was given but the sodium retention prevented by concomitant administration of furosemide, the blunted vasopressor response to angiotensin II and the hyperreninemia were not corrected. It is concluded that the effectiveness of indomethacin to correct the hyperreninemia and the blunted vasopressor to angiotensin II in the present patient was due in large part to the ability of the drug to correct sodium balance rather than by inhibition of prostaglandin synthesis.Speculation: Overproduction of prostaglandins does not play a primary etiologic role in the pathogenesis of Bartter's syndrome.


The Cumulus Humilis Aerosol Processing Study (CHAPS) provided a unique opportunity to study aerosol and cloud processing. Clouds play an active role in the processing and cycling of atmospheric constituents. Gases and particles can partition to cloud droplets by absorption and condensation as well as activation and impact scavenging. The U.S. Department of Energy (DOE) G-1 aircraft was used as one of the main platforms in CHAPS. Flight tracks were designed and implemented to characterize freshly emitted aerosols at cloud top and cloud base as well as within the cloud, i.e., cumulus humilis (or fair-weather cumulus), in the vicinity of Oklahoma City. Measurements of interstitial aerosols and residuals of activated condensation cloud nuclei were conducted simultaneously. The interstitial aerosols were measured downstream of an isokinetic inlet, and the activated particles downstream of a counter-flow virtual impactor (CVI). The sampling line to the Aerodyne Aerosol Mass Spectrometer (AMS) was switched between the isokinetic inlet and the CVI to allow characterization of non-activated interstitial particles outside of clouds in contrast to particles activated in clouds. Trace gases including ozone, carbon monoxide, sulfur dioxide, and a series of volatile organic compounds (VOCs) were also measured, as were key meteorological state parameters including liquid water content, cloud drop size, and dew point. We will report on the CCN properties in cumulus humilis. Several approaches will be taken. The first is single-particle analysis of particles collected by the Time-Resolved Aerosol Sampler (TRAC) by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with energy disperse X-ray spectroscopy (EDX). Specifically, we examine differences between activated and interstitial ones, such as differences in chemical composition and morphology. The second analysis will link in situ measurements by AMS and PTRMS with the observations by TRAC. For instance, by comparing the characteristic m/z obtained by AMS and the CO or isoprene, one can gain more insight into the role of primary and secondary organic aerosols in CCN and background aerosols. Combined with observations of cloud properties, our goal is to provide an improved picture of CCN activation in cumulus humilis.


A novel non-rigid registration algorithm within multi-resolution block matching framework is presented for accurate and robust image registration in the presence of incomplete image information. After getting the deformation field computed from block-matching, we introduce robust and structure-adaptive normalized convolution in spatial regularization of deformation field. Unlike traditional framework of normalized convolution, in which the local deformation is modified through a projection onto a subspace, however, the applicability function of structure-adaptive normalized convolution based on an anisotropic Gaussian kernel is adapted to local linear or edge structures in the images to be registered. This leads to more samples of regions of homogeneity being gathered for the regularization of deformation field, which can reduce deformation diffusion across discontinuities. A robust signal certainty is also adapted to each displacement vector in the deformation field to measure its accuracy. The results show that the method is sufficiently accurate and robust to incomplete image information for multi-temporal non-rigid image registration.


The present invention discloses a modified polymer manufacturing methods to produce a plurality of modified polymer product. The method may include retrofit existing primary manifold is modified to include a manifold and at least one modified additive injection device. The method may further comprise the conversion of the existing secondary manifold injection line is modified to include an additive polymer solidifier and in contact with the secondary manifold. Remodeled polymer production device for producing a different polymer from the finished continuous polymerization reactor.


Spike Milligan's re-telling of "John Thomas and Lady Jane". When Lord Chatterley returns from war a broken man, he puts the pieces back together only to discover that one or two important ones will never work again. So his wife must take her secret stirrings and knicker elastic elsewhere.


By implementing III-V/Si hybrid growth technique, we demonstrate the first InAs quantum-dot micro-disk laser on SOI substrates. Threshold pμmp power as low as 0.39 mW were achieved with the Q factor of 3900. © 2019 The Author(s)


Im, pH 5-5). volume of liquid was 3 ml. The substrate was added after equilibration and readings were taken for at least 20 min. to obtain an estimate of the rate of CO production. Quantitative estimations of aspartic acid were made in a similar manner except that double-side-bulb manometers were used, the second side bulb containing 0-4 ml. of 2N-H,S04, which was added after completion of the reaction to expel any bound C00. Two controls were set up with the same system but with the aspartic acid-containing solution replaced by water. The first of these contained a paper soaked in KOH soln. in the centre well. The pressure change occurring in this manometer is due mainly to a change in vapour pressure resulting from the addition of the sulphuric acid (Peel, personal communication), and the pressure changes in the other manometers were corrected by subtracting this value. The corrected pressure change in the second control was then converted into a volume and subtracted from the experimental determinations.


The paper introduces Shikumen building is the typical residence form in Shanghai,and is also the important component of the city's landscape,explores the current hidden danger in fire-fighting in the Shikumen building group,and adopts some proper fire-fighting design for its protection and reconstruction planning,so as to solve the fire-fighting problems in the buildings' reconstruction.


It's easy to vibrate in the boring bar process,the damping system is allowed to reduce the influence.The damping system consist of damping alloy,damping block and damping fluid.The damping block's mass and installation,and viscosity and viscosity-temperature characteristics of damping fluid,the choice of different alloys will affect damping property of boring bar.The loss factor of the damping alloy as the study subject,it compares the harmonic response and the max value in the ANSYS WORKBENCH at different loss factors.The results obtained at present indicate that the vibration reduction is more ideal with the loss factor increases.


Urban planners face an affordable housing crisis compounded by federal programs that eliminated subsidized housing. Prior work indicates profit-making motivations and race influenced housing removal but overlooks planning efforts to rebuild affordable housing. This paper explores the neighborhood factors affecting the redevelopment of subsidized housing under the Housing Opportunities for People Everywhere (HOPE VI) program, using multivariate regression analysis of U.S. Department of Housing and Urban Development (HUD) and Census data. Findings show housing market indicators, racial composition, and poverty rates do not predict the mix of rebuilt units, which suggests opportunities for planning to promote affordable housing goals in public–private development projects.


a system of quasi-free public schools such as exists in the United States, the entire society must bear nearly all the total cost of education rather than solely the individual receiving the education. Education has become one of the largest items in the public budget. As society has made increased investments in education, the public has exhibited a growing demand for schools to be accountable. Yet, in the past, educators have relied primarily on nonquantifiable justifications when attempting to justify the return on increased investments in education compared to the return from other forms of public or private investments. Extended qualitative discussion of the social value of education is no longer acceptable. The traditional "educated-citizenry" justification for additional expenditures is clearly insufficient. Noneconomists, particularly decision makers in the various hierarchies of government responsible for educational policy, must be provided with quantitative data and procedures to help them measure and assess the possible economic benefits of any additional "real" investments (i.e., beyond inflation) in education. A more explicit economic technique of expressing accountability is being demanded. As a procedure utilized by many corporation managers to express their accountability to owners and stockholders, cost-benefit analysis is presented as a technique that is equally applicable to educators attempting to account to taxpayers for the effective use of public funds. Prest and Turvey define cost-benefit analysis as a practical way of assessing the desirability of projects, where it is important to take a long view (in the sense of looking at repercussions in the distant as well as the near future) and a wide view (in the sense of allowing for the consideration of side effects of many kinds on many persons, in-


Image inpainting is a hot research topic via deep learned features that can generate more reasonable structures and textures compared with traditional inpainting methods. In this work, we propose a generative adversarial network with multi-scale and multi-connection structure for image inpainting. Specifically, the proposed network consists of an edge generation network and a multi-scale image completion network with multi-connection structure. Experimental results show that our method outperforms state-of-the-arts on both ICME 2019 Grand Challenge and Places2 dataset.


Abstract: The presence of benzodiazepine binding sites in rat vas deferens was detected using [3H]Ro 5‐4864 as a radioligand. The binding of [3H]Ro 5‐4864 to the mitochondrial sites is saturable, reversible, and temperature and time dependent. The association rate constant (k1) was 8.7 ± 0.7 × 107M−1 min−1, and the dissociation rate constant (k‐1) was 0.031 ± 0.003 min−1. The dissociation constant (KD) determined by saturation binding was 5.22 ± 0.56 nM. The density of binding was 4,926 ± 565 fmol/mg of protein. The Hill coefficient of binding was 0.99 ± 0.01, an indication that [3H]Ro 5‐4864 binds to a single site. The [3H]Ro 5‐4864 binding was inhibited competitively by Ro 5‐4864 and 2‐hydroxy‐5‐nitrobenzyl‐6‐thioguanosine and noncompetitively by PK 11195, nitrendipine, α,β‐methylene‐ATP, and carboxyatractyloside and was not affected by clonazepam, dicyclohexylcarbodiimide, or protoporphyrin IX. Our data indicate that [3H]Ro 5‐4864 binding sites are not identical to those labeled by PK 11195. These binding sites are modulated by the ADP/ATP mitochondrial carrier, and an interaction of dihydropyridines and [3H]Ro 5‐4864 binding sites in rat vas deferens is suggested.


1. One-parameter quntiztions (or q-anMogues) of the general linear group GL(n) are known in two wys. The standard one arises as dual tIopf algebr to the Drinfeld-Jimbo quantized enveloping algebra U(g(n)) nd is studied by many authors [5] [2] [6] [9] [8] [3]. The second one was defined by Dipper-Donkin [1]. One cn define the quantum determinant for both quntizations. It is centrM in the first case, but not in the latter case. We construct a two-prmeter quantiztion GL,(n) of GL(n) depending on two units , in the base ring. The above known q-analogues are obtained as special cases by taking (q, q) nd (1, q) as (, ) respectively. Further, we construct two-parameter quantized enveloping algebra U, associated with GL,(n). The Drinfeld-Jimbo algebra U(g(n)) is obtMned s a quotient Hopf algebr of U,. 2. We work over a commutative ring k. Let nd be two units in k. Let M, be the k-algebra defined by n generators x (1i, ]_n) and the following relations" (2. 1) zx---xx (2. 2) xx,=x,x (2.3) xx=o-xx,


With the aid of the integral transformation,the symplectic system is introduced into the problem of two-dimensional thermo-viscoelasticity and the dual equations of the fundamental problem are constructed.All solutions of Saint-Venant problems can be obtained directly via zero eigenvalue eigensolutions,which satisfy the conjugated relationships of the symplectic orthogonality.Meanwhile,an effective method for boundary problems is provided by the technologies of variable substitution and eigensolution expansion.Numerical examples show that the symplectic method is effective for some typical boundary problems with creep and relaxation characteristics of thermo-viscoelasticity.


For readers with a special interest in the development and history of popular Catholicism, Carroll includes much that is interesting and informative. On the whole however, this is a book for psychoanalysts, or at least for those with a taste for psychoanalytic argument. Those less psyc'hoanalytically-minded may remain unconvinced. That infants for example, German or otherwise, take any special interest in their faeces is not a universally accepted assumption. Those who question the plausibility of the premises will find it extremely difficult to accept any conclusions, however ingenious, that may follow from them. This would seem to be a general occupational hazard for the psychoanalyst.


Large amounts of data are only available in textual form. However, due to the semistructured nature of text and the impressive flexibility and complexity of natural language the development of automatic methods for text analysis is a challenging task. The presented work is centered around a framework for analyzing document (collections) that takes the whole document analysis process into account. Central to this framework is the idea that most analysis tasks do not require a full text understanding. Instead, one or several semantic aspects of the text (called quasi-semantic properties) can be identified that are relevant for answering the analysis task. This permits to targetly search for combinations of (measurable) text features that are able to approximate the specific semantic aspect. Those approximations are then used to solve the analysis task computationally or to support the analysis of a document (collection) visually. The thesis discusses the above mentioned framework theoretically and presents concrete application examples in four different domains: literature analysis, readability analysis, the extraction of discriminating and overlap terms, and finally sentiment and opinion analysis. Thereby, the advantages of working with the above mentioned framework are shown. A focus is put on showing where and how visualization techniques can provide valuable support in the document analysis process. Novel visualizations are introduced and common ones are evaluated for their suitability in this context. Furthermore, several examples are given how good approximations of semantic aspects of a document can be found and how given measures can be evaluated and improved. Figure 1: Graphical summary, showing frequent terms of the dissertation. The image was generated with the tool Wordle (www.wordle.net).


A compact aircraft lidar using a Nd:YAG pulsed laser, fiber coupled telescope, and three-channel receiver was flown in the Norfolk-Virginia Beach and California Central Valley regions to show lidar can reveal complex regional aerosol distributions.


The first (Phase I) joint US-USSR test of US electrode materials was carried out in Moscow between September 25 and October 8, 1975 in the Soviet U-02 MHD facility. The test procedure was designed to test five different zirconia based materials and the cathode and anode electrode wall modules under MHD operating conditions. The materials which were selected were 88ZrO/sub 2/-12Y/sub 2/O/sub 3/, 82ZrO/sub 2/-18CeO/sub 2/, 50ZrO/sub 2/-50CeO/sub 2/, 25ZrO/sub 2/-75CeO/sub 2/ and 20ZrO/sub 2/-78CeO/sub 2/-2Ta/sub 2/O/sub 5/. Each of the five electrode materials had four different current densities established between the anode and cathode during the experiment which lasted a total of 127 hours; 100 hours under MHD power operational conditions. There were also extensive tests made on the modules before their shipment to the USSR and after their installation into the U-02 channel but before the start of the 1st phase. All except six electrode pairs performed satisfactorily during the entire test. These were the pairs which were designated to carry maximum or near maximum current density. Five pairs failed early in the life test and the sixth pair failed in the last several hours. Failure was not due to the electrode materials, however, but due to lead-outmore » melting caused by joule heating in the platinum wires. The U-02 facility is fully described and the operational parameters are given for each phase of the test. The electrode and insulating walls are described and the appropriate parameters that are used to predict the performance of the module are given. (WHK)« less


The anaerobic granular sludge is combined with aerobic activated sludge as seeding sludge and after 95 days arobic granular sludge is successfully cultivated in SBR reactor by preaeration and adjusting influent loading with monosodium glutamate wastewater. The colour of particle presents yellow and the outline is neatly observed with its average particle size about 0. 5 mm. In mature cultivation period,the average removal rate of COD and nirogen can reach 91. 8% and 96. 6% respectively,parameter of SVI is maintained at about 20 mL /g and the concentration of sludge reaches about 8 000 mg /L.


The aim of this study was to examine job satisfaction among private and public banking sector in Punjab Pakistan and how different factors affect the job satisfaction. This research explained the factors which create the job satisfaction. These factors are supervision, job security, promotional opportunities, relationship with co-workers and pay. The result of the study shows that most of the employees in banking sector are satisfied with their job. Positive correlation was found between job satisfaction and job security, good supervision, promotional opportunities, pay and relationship with co-worker. Furthermore, Independent T-test was used to see the job satisfaction between employees of public and private sector. There was no significant difference of satisfaction between Public Sector employees and private sector employee in banking sector.


ABSTRACT Reductions to 2, 5, and 42% of the wild-type transformation efficiency were found when Agrobacterium mutants carrying transposon insertions in virD2, virC2, and virE2, respectively, were used to transform Aspergillus awamori. The structures of the T-DNAs integrated into the host genome by these mutants were analyzed by Southern and sequence analyses. The T-DNAs of transformants obtained with the virE2 mutant had left-border truncations, whereas those obtained with the virD2 mutant had truncated right ends. From this analysis, it was concluded that the virulence proteins VirD2 and VirE2 are required for full-length T-DNA integration and that these proteins play a role in protecting the right and left T-DNA borders, respectively. Multicopy and truncated T-DNA structures were detected in the majority of the transformants obtained with the virC2 mutant, indicating that VirC2 plays a role in correct T-DNA processing and is required for single-copy T-DNA integration.


It is an optical navigation device that controls the brightness of an adjustable light source, and a method described in the same. Light from the light source is emitted to a surface and reflected by the surface to a sensor. The light that is received by the sensor is used to measure a movement of the optical navigation device relative to the surface. A photosensitive device also receives light from the light source. The brightness of the light source can be set to light according to the amount received at the light-sensitive device.


Performance management is an effective way to enhance the competitiveness of construction enterprises. This paper analyzed the significance and the problems of the current construction enterprise performance management, proposed a new performance management system which is people-oriented and relatively objective. This system includes some KPI which combined the conventional KPI and improved KPI, and establishes a cycled performance evaluation model. Finally through the comparison, it shows the new one is better than the old one in purpose, scientific and humanistic aspects. This paper maybe provide some help and suggests to performance management personnel in construction enterprise.


We test the hypothesis that, being clients not fully informed on the expected benefit from fulfilling the disputes and being incentives of lawyers not aligned to those of their clients, the demand for legal disputes in Italy is induced. This hypothesis finds empirical support for a sample of Italian legal districts.


Background Lesinurad (RDEA594) is a selective uric acid reabsorption inhibitor (SURI) investigated for treatment of gout in combination with xanthine oxidase inhibitors (XOI). Objectives Investigate efficacy as assessed by a composite endpoint of serum uric acid (sUA) target and no flares in gout patients with inadequate response to XOIs alone from three Phase 3 clinical trials examining treatment with lesinurad in combination with allopurinol (ALLO) or febuxostat (FBX). Methods CLEAR 1 (NCT01510158), CLEAR 2 (NCT01493531) and CRYSTAL (NCT01510769) were 12-month, randomized, double-blind, Phase III trials to evaluate lesinurad (LESU; 200 mg or 400 mg oral, qd) in combination with ALLO vs ALLO + placebo (PBO) (CLEAR 1 and 2) or in combination with FBX vs FBX+PBO (CRYSTAL). A post-hoc composite endpoint defined as the proportion of patients reaching target sUA level (<6 mg/dL in CLEAR 1 and CLEAR 2 and <5 mg/dL in CRYSTAL) and no gout flares was assessed monthly starting at month 7 (after flare prophylaxis was to be discontinued) in each study and in a pooled analysis. Results CLEAR 1 (N=603), CLEAR 2 (N=610), and CRYSTAL (N=324) patients, respectively, were primarily male (94.0%, 96.2%, and 95.4%); mean ± SD age was 51.9 ± 11.3, 51.2 ± 10.9, and 54.1 ± 11.0 years and duration since gout diagnosis was 11.8 ± 9.4, 11.5 ± 9.3, and 14.7 ± 10.9 years. Most CLEAR 1 and CLEAR 2 patients (90.5% and 84.1%) received ALLO 300 mg daily (range: 200–600 mg and 200–900 mg, respectively). For CLEAR 1 and CLEAR 2, LESU at both doses in combination with ALLO significantly increased proportions of patients achieving the composite endpoint (sUA target <6.0 mg/dL and no flares) vs ALLO+PBO at all visits, with approximately twice as many LESU patients achieving the composite endpoint (p<0.001). For CRYSTAL, LESU at both doses in combination with FBX increased proportions of patients achieving the composite endpoint (sUA target <5.0 mg/dL and no flares) vs FBX+PBO at all visits, with approximately 40% more LESU patients achieving the composite endpoint (p=0.374 to p=0.002). A pooled analysis of LESU at both doses in combination with ALLO or FBX significantly increased proportions of patients achieving the composite endpoint sUA target vs ALLO+PBO or FBX+PBO at all visits, with approximately twice as many LESU patients achieving the composite endpoint (p<0.001). Sensitivity analysis comparing gout flares requiring treatment (rather than all flares) and sustained achievement of composite endpoint were also carried out. Conclusions Significantly greater proportions of patients responded to the combination of lesinurad (200 or 400 mg) + XOI, with approximately twice as many achieving the composite endpoint of sUA target and no flares compared with patients treated with XOI+PBO. Combination therapy with lesinurad + XOI represents an option for gout patients who warrant additional therapy Acknowledgement Research sponsored by Ardea Biosciences/AstraZeneca. Editorial support was provided by PAREXEL and funded by AstraZeneca. Disclosure of Interest P. Khanna Grant/research support from: AstraZeneca, S. Baumgartner Employee of: Ardea Biosciences, Inc., a member of the AstraZeneca Group, J. Robinson Employee of: Ardea Biosciences, Inc., a member of the AstraZeneca Group, E. Tafesse Employee of: AstraZeneca, R. Morlock Employee of: Ardea Biosciences, Inc., a member of the AstraZeneca Group


In order to establish the energy conservation strategy in canning of acid food, the enery consumption of peach canning factory was monitored. The energy intensity was investigated and quantification of thermal and electrical energy was undertaken in individual operations. For processing of 1 kg raw peach, thermal energy 864 kcal and electrical energy 0.045 KWh was consumed in overall factory. From daily processing of 14 M/T peach, 2060 kg waste like seeds and 1510 kg low grade product were produced, and syrup of 6240 kg was prepared for filling in can. Enery intensive operations were lyepeeling(35%) and pasteurization(53%). Steam quality in the monitored factory was in the range of with no difference among processing lines and 23% of supplied thermal energy in pasteurization was utilized actually for heating food.


The surface structure of GaAs(001)-c(4 · 4) was investigated by synchrotron surface X-ray diffraction which is sensitive to both inplane and out-of-plane structures. The atomic coordinates and Debye–Waller factors for up to the sixth layer from the surface are given. The resultant atomic coordinates were compared with those given by a first-principles calculation. Among a variety of heterodimer models that were examined by theoretical calculation, our data fit best a three-heterodimer model where three Ga–As heterodimers are present in one unit cell. The preference for the formation of heterodimers is discussed in relationship to the transition process from the 2 · 4 to the c(4 · 4) structures. 2006 Elsevier B.V. All rights reserved.


Background: Increased c-Met activity has been implicated in numerous oncologic processes. However, its prevalence among different cancers, association with demographics and genetic aberrations, and implication in therapy resistance has not been fully described. Patients and Methods: Between May 2010 to November 2012, 3607 patients were referred to the investigational cancer therapeutics department at MD Anderson Cancer Center for consideration of a phase I protocol. Among these patients, 1115 underwent MET amplification testing via fluorescence in-situ hybridization and were included in this analysis. Copy numbers are expressed as a ratio to the centromeric gene CEP7 with amplification defined as MET/CEP7 ≥2 or >20 gene copies in >10% of nuclei. Patient demographic, histologic, and molecular characteristics were stratified based on MET amplification status. Among patients with MET amplification, 20 were treated on a phase I protocol and evaluated for therapy response. Responses were categorized by RECIST criteria with objective responses defined as stable disease lasting ≥6 months or any observed partial responses. Categorical variables were compared via Chi-Squared and Fisher Exact Tests, while continuous variables were compared via Student9s T-Test. Overall survival from the date of first consultation at our phase I clinic were compared via the Log-Rank test. Results: Twenty-nine (2.6%) patients exhibited MET amplification (median 3.48; range 2.05-16.14). Of these, 2 exhibited MET/CEP7 ratios 20 MET copies among >10% of nuclei. The highest prevalence was in tumors of adrenal (2 of 13; 15%) and renal (4 of 28; 14%) origins. Stratifying by MET amplification status, no differences were observed in demographic characteristics including age, ethnicity, or gender (all P>0.10). Amplified patients exhibited more organ systems involved with metastatic disease (median 3 vs. 4, P=0.0005). MET amplification was correlated with higher incidence of BRAF mutation, high-grade histology, and PTEN loss (all P Conclusions: Although caution must be stressed when interpreting these results, MET amplification exhibits an association with higher metastatic burden, specific molecular characteristics (BRAF mutation, PTEN loss), and high grade histology. Patients with MET amplification in this cohort exhibited a high response rate to VEGFR inhibitors while c-Met targeted agents showed little activity. Citation Format: Chad Tang, Denis Jardim, Debora Gagliato, Gerald Falchook, Kenneth Hess, Siqing Fu, Jennifer Wheler, Ralph Zinner, Aung Naing, Apostolia Tsimberidou, Funda Meric-Bernstam, David Hong. Analysis of 1115 patients tested for MET amplification and therapy response in the MD Anderson phase I clinic. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4424. doi:10.1158/1538-7445.AM2014-4424


A review of the fossil and subfossil avian record kept in Bulgaria is presented. The only collection of fossil birds in Bulgaria was established in the 1980s. 99.6% originates from 98 localities throughout Bulgaria. Foreign fossils originate from Azerbaijan, Greece, Hungary, Namibia and New Zealand. Bulgarian avian fossil and subfossil records in collections outside the country are found in museums in France, Germany, Poland and the United Kingdom. In August 2003 the collection numbered 13,848 bones, two casts and one eggshell representing 349 taxa. Taxonomic composition includes: 22 fossil species, one fossil subspecies, one subfossil species, one subfossil subspecies and at least 160 recent species. This collection became the largest avian palaeontological collection of the Balkan during the last 15 years.


Clients frequently present to primary and secondary services with drug and alcohol dependence problems, and it is important that clinicians can identify and accurately assess the problem and have an awareness of some of the pharmacological and psychosocial interventions available. This article focuses on three commonly misused substances: alcohol, opiates, and crack/cocaine, and considers the specific treatment options.


Aim and Scope: This paper presents the material and results of clinical studies of herpesvirus infections, posing currently an urgent problem for both healthcare and society as a whole. Today, the state of chronic inflammation, responsible for the development of a number of pathological processes in human, attracts a great interest of researchers. Along with this, it is also worthwhile to pay attention to the indicator such as burden of the disease. Materials and Methods: Due to the severity of the disease and its long treatment period, it seems important to effectively treat patients with the task of reducing the burden of the disease. In terms of the economic burden, the proposed approach is less expensive. For parents, the burden of the disease on the proposed approach is less by 4.98 times compared with the traditional approach. For the state, the burden on the proposed approach is less by 5.71 times compared with the traditional approach. According to the proposed method, the period of full recovery was 2 months. Traditional method, at the same time, ensured only temporary improvement. Result and Discussion: The examined patients sought medical help with a large number of complaints and symptoms. Attention was paid to a decrease in the hemoglobin level in some patients. The majority of patients (71.7%) had degree 1 anemia; the second degree was diagnosed in 18.5% of children, and the third in 10.3% of the examined patients. Later, to verify the type of anemia, a comprehensive evaluation of the ferrokinetic indicators was carried out. Conclusion: The disease lasted for 1.5 years (18 months) until the proposed approach was applied.


One of the most inconvenient of Broad Area Semiconductor Lasers is the large amount of spatial modes involved in the output beam and the possible temporal unstabilization due to their interaction. This introduces strong difficulties in the output beam focalization in order to be coupled to fibers or other devices. One possibility to increase the output beam quality of these devices is a spatial modulation of the Gain/Loss and refraction index in the amplifying material that can improve the signal/noise ratio during beam propagation. We consider a static model that can be linearized for low intensities allowing an analytic treatment of the problem. An interesting and technologically useful effect is the simultaneous spatial filtering and focalization behind the material.


Papalia T, Greco R, Lofaro D, Maestripieri S, Mancuso D, Bonofiglio R. Impact of body mass index on graft loss in normal and overweight patients: retrospective analysis of 206 renal transplants.
Clin Transplant 2010: 24: E241–E246. © 2010 John Wiley & Sons A/S.


Nurses make up the largest segment of healthcare workforce and find themselves on the front lines of treating patients with various mental and physical ailments. Thus, it can be hard for them to cope with their personal health and life instances. Grit is the term given to a non-cognitive, positive personality trait which is based on a person's individual perseverance of effort combined with the passion for a particular long term goal or end state. Social Support refers to how individuals perceive friends, family members and others as sources available to provide overall support during times of need. The present study focuses on examining the relationship between grit and quality of life among nurses and also the mediating role of social support. A sample of 158 nurses was administered with the Short Grit Scale by Angela Duckworth (2009), Quality of Life Scale by Sharma and Nasreen (2014) and Multidimensional Scale of Perceived Social Support by Zimet, Dahlem, Zimet & Farley (1988). The relationships between grit, social support and quality of life were examined using correlation analysis and hierarchical regression analysis. A positive correlation of grit and social support with quality of life was revealed. Hierarchical regression analysis showed that grit and social support contributes in increasing the levels of quality of life among nurses. Social support was found partially mediating the link between grit and quality of life.


prosurvival properties [5]. Under these condi‐ tions, it is fair to conceive that all activated lymphomyeloid cells expressing the IL‐15R and exposed to GIFT15 would lose their capacity to trigger immune responses. In light of these results, we tested whether the expression of the fusokine could protect xenografted cells from rejection in immune competent animals. While mice lacking GIFT15 rejected all grafted cells, animals treated with the fusokine have toler‐ ated the xenograft [4]. These results suggest that GIFT15 can act as a suppressor agent of allograft rejection and allows for xenotransplant as well and may present an interesting tool for the treat‐ ment of autoimmune diseases. While studying the pharmacological properties of GIFT15 on unfractionated splenocytes in vitro, we observed that the fusokine had a remarkable and unprece‐ dented effect on naive B cells, converting them into suppressor cells of B‐cell ontogeny (h ereafter GIFT15 Bregs) [6].


It is found that the deviation of an effective potential from the quartic form is related to the metric and vector torsion dependencies of the effective potential in the vector torsion coupled conformally induced gravity.


Introduction: Recent trials using insertable cardiac monitors (ICMs) show high rates of atrial fibrillation (AF) in those at risk of developing AF based on demographics. Further identifying subsets who could benefit most from ICMs is desirable. We evaluated if the recently-developed HAVOC risk score which has predicted AF in cryptogenic stroke patients also predicts AF detection by ICMs in those without a recent stroke. Methods: Participants from the prospective REVEAL AF study, which reported frequent clinically unrecognized AF in patients at risk for AF (CHADS2 scores ≥3 or =2 with ≥1 additional risk factor), with ICM data and not on anti-arrhythmic drugs were included. Ischemic stroke <1 year ago excluded participation. HAVOC scores were calculated using points for hypertension (2), age ≥75 (2), valvular disease (2), vascular disease (1), obesity (1), congestive heart failure (4), and coronary artery disease (2). Prior stroke, an AF outcome, generally not a cause, is not included. Score classification ...


In order to look for a well-behaved counterpart to Dolbeault cohomology in D -complex geometry, we study the de Rham cohomology of an almost D -complex manifold and its subgroups made up of the classes admitting invariant, respectively anti-invariant, representatives with respect to the almost D -complex structure, miming the theory introduced by Li and Zhang (2009) in [20] for almost complex manifolds. In particular, we prove that, on a 4-dimensional D -complex nilmanifold, such subgroups provide a decomposition at the level of the real second de Rham cohomology group. Moreover, we study deformations of D -complex structures, showing in particular that admitting D - Kähler structures is not a stable property under small deformations. © 2012 Elsevier B.V. All rights reserved.


Heart failure remains the leading cause of mortality worldwide, largely due to the lack of regenerative capacity of mature cardiomyocytes. The advanced understanding of cardiac architecture and function is critical to uncover the underlying mechanism of cardiac morphogenesis and the remodeling process in response to myocardial infarction. Recent progress has demonstrated that zebrafish and neonatal mice have the capacity to restore cardiac function following the injury, laying the foundation to investigate the cues to structural and functional abnormalities. For this reason, we have developed a light-sheet fluorescence microscope along with the tailored computational methods to investigate the 3-dimensional (3D) architecture of the intact mouse heart, and 4D (3D spatial + 1D temporal) cardiac contractility in zebrafish larvae. This method provides us ~ 2 um isotropic spatial resolution across the atria and ventricles with minimal photo-damage and maximal penetration depth. In combination with established tissue clearing methods, we are able to investigate myocardial trabeculation and compaction in mouse hearts within the 2-minute laser scanning. To unravel the contractile dysfunction following the anticancer therapy, we have coupled our imaging system with retrospective synchronization algorithm for the 4D reconstruction of myocardial deformation from end-systole to end-diastole in zebrafish hearts. To further interpret the deluge of 3D and 4D images, we have also developed a machine learning-based platform for interactive image analysis. Collectively, our multi-scale imaging strategy provides an entry point to assess micro-architecture and cardiac contractile function in the entire heart without physical slicing, holding the great potential to uncover the process of cardiac morphogenesis and regeneration.


Ultrasonic wave of 19.5 kHz frequency oscillated with an ultrasonic transducer and amplified with a step type of horn was irradiated on metal surface in water to introduce compressive residual stress. Slight plastic deformation occurred at the surface region of pure metal such as Cu and compressive residual stress was introduced. It seemed that the plastically deformed depth from the surface corresponded approximately to the region where the compressive residual stress is extended from the surface. The higher compressive residual stress could be introduced into the surface of Cu-Zn brass and SUS304 stainless steel because work-hardening was simultaneously induced to those alloys. Furthermore, since martensitic transformation was induced by the plastic deformation in the case of SUS304, the lager compressive residual stress could be introduced more deeply into the surface region. The residual stress of SUS304 surface reached to the maximum value of 574 MPa by irradiating for 5 min and the stress extended to the depth of about 170μm from the surface.


Abstract : This thesis reviews our knowledge of power to date and places it into several conceptual categories by providing tentative answers to the following three questions: 1. Why are the dynamics of power necessarily an important part of managerial processes? 2. How do effective commanders acquire power? 3. How and for what purpose do effective commanders use power? The following are the key conclusions drawn from this literature review: 1. Commanders are dependent on subordinates and others to accomplish their tasks, and power is the fuel that generates their results. 2. Effective commanders are very sensitive to developing all their sources of power. 3. They use their power for the good of the whole organization rather than for personal aggrandizement. Originator supplied keywords include: Power bases; Personal power; Position power; Power motivation.


Trade secrets are commonly seen in business operation. They are important part of the intellectual property rights of enterprises and can bring great benefit. However, losses are often made through the trade secret revealed due to the lack of security-consciousness and security regulation. By analyzing the status and reasons of trade secret revelation in China, the paper discusses some effective ways to keep trade secrets among enterprises.


Previous studies on risk factors for resection and postoperative recurrence in Crohn's disease have given inconclusive results. The aim of this study was to assess the risk for resection and postoperative recurrence in the treatment of ileocaecal Crohn's disease and to define factors affecting the course of the disease.


We survey the basic principles behind the application of model checking to controller verification and synthesis. A promising development is the area of guided model checking, in which the state space search strategy of the model checking algorithm can be influenced to visit more interesting sets of states first. In particular, we discuss how model checking can be combined with heuristic cost functions to guide search strategies. Finally, we list a number of current research developments, especially in the area of reachability analysis for optimal control and related issues.


Investigations of quantitative and qualitative changes in protein synthesis in two winter wheat varieties have been made during the early stages of cold hardening. When labelling with 35S is made during the hardening treatment, the incorporation of the tracer into proteins is very low in both varieties. However, if labelling at 22 °C precedes hardening, the hardy variety, Kharkov, shows an increase in the incorporation of 35S into the total soluble proteins, and the rate of synthesis of both chloroplast and membrane proteins is maintained during the hardening process. In the less-hardy Selkirk, a very marked decrease in proteogenesis has been observed.Qualitative studies on the incorporation of 35S have not revealed any changes in specific chloroplast and membrane proteins during early stages of cold hardening of the two varieties of winter wheat.


To the Editor: In the early 1960s, a research team at the biophysics department of the Weizman Institute of Science, Rehovot, Israel, was determined to develop polypeptides able to elicit an immune response when injected into animals. To this end, they designed an immunogenic polypeptide of approximately 4000 Da (glatiramer acetate, copolymer 1, Copaxone) consisting of only 4 amino acids (alanine, glutamic acid, lysine, and tyrosine) and resembling the protein composition of myelin basic protein (MBP). MBP is the main protein component of the myelin sheath in the spinal cord and of white matter in the brain and represents one of several putative autoantigens in multiple sclerosis (MS). Several mammalian animal models have demonstrated that crude injections of myelincontaining tissue causes experimental allergic encephalitis (EAE), which closely mimics MS. Surprisingly, injection of glatiramer acetate (GA) suppressed rather than induced EAE in mammalians.1,2 A first prospective, double-blind, placebo-controlled clinical trial in MS patients conducted by Bornstein et al provided the first evidence of therapeutic effects of GA. Daily subcutaneous injections of 20 mg of GA for 2 years significantly reduced disease progression and frequency of relapse in MS patients.3 Large multicenter trials confirmed the initial observations made by Bornstein et al.4 In 1996, GA was eventually approved by the Food and Drug Administration (FDA) for the treatment of the relapsing-remitting form of MS. Today, Copaxone constitutes an important therapeutic tool in the treatment of MS and is characterized by a high safety profile and only minimal side effects such as irritation at injections sites and, rarely, transient vasomotor response. Extensive studies on the mechanisms of action of GA demonstrated that GA exerts its therapeutic effect by modulating the immune response at different levels of specificity. GA binds promiscuously and with high affinity to various class II major histocompatibility (MHC) molecules of murine and human origin, displacing antigens from the MHC antigenbinding site. This leads to the inhibition of various pathological effector functions.5 Furthermore, GA acts as a potent inducer of Th2/3 cells that secrete high amounts of regulatory substances such as interleukin-10 (IL-10) and transforming growth factor(TGF), but not Th1 inflammatory cytokines, thus deviating the immune response from a Th1to a Th2-biased cytokine profile.6 The Th1-mediated immunopathological nature of inflammatory bowel disease (IBD), in particular, Crohn's disease, prompted researchers to examine the effects of GA in IBD. Indeed, previous studies convincingly demonstrated that GA treatment ameliorates the various pathological manifestations of several IBD animal models including trinitrobenzene sulfonic acid–induced colitis and dextran sulfate sodium (DSS)–induced colitis, as well as a spontaneous model of colitis in C3H/HeJBir IL-10deficient mice.7,8 In these mouse models amelioration of clinical symptoms such as weight loss, intestinal bleeding and diarrhea was accompanied by reduced expression of proinflammatory cytokines such as tumor necrosis factor– and interferonand enhanced levels of regulatory anti-inflammatory TGFand IL-10. Recently, the finding of a direct association between the therapeutic effects of GA in IBD and its immunomodulatory effect in the injured colon was unveiled.9 In this study, naive mice were immunized by GA, leading to the generation of a Th2/3-subtype T-cell population that drastically suppressed disease manifestation on their adoptive transfer to mice with DSS-induced colitis. In contrast, adoptive transfer of control lysozyme-specific cells did not result in any beneficial effect on the disease. In addition, GA-specific shortterm T-cell lines were in the inner layer of the colon after intraperitoneal injection in colitis-induced mice and secreted the regulatory cytokine TGFin situ.9 Here, we report a 33-year-old male white patient who was diagnosed with the relapsing-remitting form of MS 7 years ago at age 26. One year later, in April 2001, Crohn's disease with mild to moderate ileocoecal involvement was diagnosed, and treatment with steroids and regular follow-up visits in our IBD outpatient clinic were initiated. In September 2001, daily injections of 20 mg of Copaxone were started for treatment of MS. Retrospectively, bowel symptoms such as abdominal pain, stool frequency, and intestinal bleeding were drastically reduced a few weeks after commencement of Copaxone treatment, and the patient achieved full remission of Crohn's disease without the need of any concomitant IBD treatment. In 2006, the Copaxone treatment was discontinued because of remittent exacerbations of the MS, and methotrexat treatment (10 mg/week) was started. Soon after the termination of Copaxone, bowel symptoms flared up again, and the patient complained of abdominal pain and increasing stool frequency with the addition of blood. Furthermore, ultrasonography revealed markedly enhanced disease activity in the terminal ileum (Fig. 1). After consultation with the neurologist in charge, we decided to reinitiate Copaxone treatment. Soon after, bowel symptoms alleviated, and the patient again achieved full remission of Thomas M. Gress and Martin Steinkamp shared last authorship. Copyright © 2008 Crohn's & Colitis Foundation of America, Inc. DOI 10.1002/ibd.20537 Published online 14 July 2008 in Wiley InterScience (www.interscience.wiley.com).


Open source software (OSS) creates the potential for the inclusion of large and diverse communities in every aspect of the software development and consumption life cycle. However, despite 6 years of effort by an ever growing research community, we still don't know exactly what we do and don't know about OSS, nor do we have a clear idea about the basis for our knowledge. This paper presents an analysis of 155 research artefacts in the area of open source software. The purpose of the study is to identify the kinds of open source project communities that have been researched, the kinds of research questions that have been asked, and the methodologies used by researchers. Emerging from the study is a clearer understanding of what we do and don't know about open source software, and recommendations for future research efforts


The information about the engineeringgeological conditions in the central part of St. Petersburg which are characterized by deep thickness of weak water saturated soil is given. Three buildings with large underground space constructed in St. Petersburg are considered as examples. The depth of each space exceeds 12 m and required the usage of modern and nonstandard construction and technological methods for protection of the ditch walls. The wall protection was done by sheet piles, by "Wall in ground" method, and "jet grouting". The soil excavation was carried out by traditional method or "Top–down" method. The basic constructive schemes and technological methods of ditch excavation, test results of deformation of the protection walls during excavation of the ditch and the settlements of the neighboring buildings are given. underground space in St. Petersburg are given in the present article. 2 FIVE LEVEL UNDERGROUND PARKING ON KOMENDANTSKAYA SQUARE In 2006 the company "GEOIZOL" made the project and started construction of the circular 5 level underground parking on Komendantskaya Square. The depth reached 19,5 m and the diameter 78 m. The general cross section is shown in Figure 1. The main problems which appeared during the construction were the absence of the experience in the construction of such types of buildings


Economic analysis of micro CHP cogeneration using a low-resolution data could raise several accuracy doubts, especially if the data input that's being dealt with is a household demand profile. Household demand profiles have been always showing dynamics that could be hidden within the low-resolution data. Such dynamics could significantly affect the output result of modeled simulation and consequently affect the overall economic analysis of the system. Modeling the dynamics of the demand profiles could enhance the economy-based decisions of the micro CHP system. Through out the paper, a mean was found to increase the data resolution of an electrical load profile through adding harmonics to the low-resolution load profile to simulate secondly measured electrical load profile. An economic analysis of micro-CHP cogeneration is discussed through comparing the effect of increasing the data resolution through harmonics addition versus using the mean value of the available data. The harmonics frequencies and amplitudes are extracted from any available load profile of one-day measurements, or could be estimated from the available load profile on the account of accuracy. Through this one-day accurate measurement, a noise profile is created and applied on the low-resolution load profiles. Such load profiles could be daily, monthly, yearly, or of a longer time frame. Only one condition applies, which is the noise profile extracted from certain system, must be applied to the same system. The algorithm of extracting the noise profiles and applying it to the low-resolution load profiles was developed on Matlab and tested on several load profiles of different sampling frequencies. The results show a noticeable increase in accuracy of the data in comparison to the used average values of the available data, which in turn affect the economics of the micro-CHP.


Background: Listeria monocytogenes is the causative agent of listeriosis, a highly fatal opportunistic food borne infection. Listeriolysin O is a major virulence factor in this bacterium, which is encoded by hlyA. The aim of the present study was to determine the relation of Listeria monocytogenes hlyA gene isolated from fresh cheese with habitual abortion in Marvdasht. Materials and methods: In this cross-sectional study, 428 fresh cheese samples from four geographical area of Marvdasht were collected, then cold enriched and cultured in Hicrome Listeria Agar and Palcam Agar. Specific biochemical and sugar fermentation tests were used for identification of probability bacteria. Finally, hlyA gene was determined by PCR method. Results: Of 428 samples, 56 (13.1%) L. monocytogenes were isolated, among which 91.7% were revealed to encode hlyA. Data analysis revealed significant association between months of sampling and isolated bacteria (p<0.004). Also, there was a significant association between bacteria and hly A gene with human abortion. Conclusion: Fresh cheese and unpasteurized milk contaminated with L.monocytogenesis can be one of the reasons of habitual abortion in Marvdasht. Therefore pregnant women and immunocompromised people are strongly recommended not to consume fresh cheese and unpasteurized milk.


Mercury (Hg) is a toxic pollutant and it can be strongly accumulated in the food chain, especially in Polar Regions. This paper presents a part of the work that has been on-going for 3-4 years in Ny-Alesund, Svalbard within the frame of an international collaboration. In Ny-Alesund in spring 2003, the atmospheric chemistry of mercury has been studied so as to better understand the formation of oxidized mercury species in the atmosphere that could be deposited onto snow surfaces. The role of snow as a potential source of mercury to the atmosphere or as a sink has also been approached to better understand the behavior of this metal. Chemical and biological processes seem to play a major role in Hg storage in snow. When melting, snow could be a major source of Hg into the various ecosystems and this toxin could therefore be accumulated into the food chain.


Abstract India has a huge potential for numerous crops production which are proficiently valued for small grower to the highest producers. Considering, the social and economic applicability, especially in case of productivity both in quality as well as the quantity. Multiple factors are stick with economically important crops, among all, plant viruses are predominant. Emphasising begomovirus has emerged as severe constraints of the production of many crops in tropical and sub-tropical regions. The largest genus Begomovirus are naturally transmitted by whiteflies (Bemisia tabaci) infecting a wide variety of crops with significant losses. This review stress on current status of begomoviruses infecting various crops varieties and approaches for its management. We focused on the pathogenesis, genetic flexibility and recombination of begomovirus responsible for the wide host range. The present study entails the view and understanding of different approaches for the begomovirus management which state knowledge about limiting the crop losses.


This article describes our experience in the implementation of Good Laboratory Practice (GLP) in a research group of the Department of Microbiology in the University of Barcelona (UB). Some issues relating to quality assurance in a research laboratory setting are reviewed, and several comments and suggestions arise from our experience in setting up GLP. Copyright © 2005 John Wiley & Sons, Ltd.


LiDAR (Light Detection and Ranging) is an active remote sensing technology which provides 3D information of the terrain and vegetation. LiDAR data with pulse density ~1 return per square meter is sufficient for forest inventory applications in general cases. It is also possible to assess vegetation height and density directly from LiDAR data. However, compared to optical or radar satellite data airborne LiDAR data is not efficient tool when high temporal resolution and very large area mapping is required. LiDAR-Assisted Multi-source Programme (LAMP) is a forest inventory methodology that integrates LiDAR data with satellite data and field data for estimating forest characteristics, such as biomass and carbon stocks for large areas. It takes advantage of LiDAR's high precision and satellite data's good temporal and spatial coverage. LAMP methodology was applied in three case studies in tropical countries, namely LAO PDR, Nepal and Ghana. Wall-to-wall LAMP biomass estimates were produced for a grid with a cell size of maximum 1 hectare and verified against field data. The case studies proofed that LAMP is a scal able, fast, robust and cost-efficient approach for estimating forest carbon and biomass. The achieved results indicated that LAMP methodology is a promising approach for achieving Tier 3 requirements of REDD+ in measuring, reporting and verification (MRV) at the national and sub-national scales. * Corresponding author. This is useful to know for communication with the appropriate person in cases with more than one author.


With the convenience to add or replace sensors, to maintain and extend, a new solution of wireless sensor network based bridge health monitoring system for long-span bridges was proposed, which includes advanced and low power-consumption sensors, wide-range short-distance wireless communication module, high-speed long-distance wireless communication module, efficient and practical management software. 433 MHz industrial wireless module was selected for short-distance wireless communication among nodes and between nodes and gateways. 3G WCDMA was chosen for long-distance wireless communication between gateways and the control centers. Whole process controlled management software was specially developed.


Observations of fecundity from the most recent Western horse mackerel spawning stock biomass survey suggest that the species is an indeterminate spawner and therefore the current model of fecundity, used in the calibration of the stock assessment, may be inappropriate. The stock is assessed by fitting a linked Separable and ADAPT VPA-based model to the catch-at-age data and to the egg production estimates. The assumption is made that egg production and spawning stock biomass are linked by a constant but unknown fecundity parameter, estimated within the model. In this study, the sensitivity of the model structure to alternative fecundity relationships is explored. The introduction of models linking biological indicators of fecundity, such as lipid content or feeding intensity during the spawning season is examined. The impact on the perception and management of this stock is evaluated within a simulation framework. Simulations suggest that care must be taken when incorporating time series of proxies when the underlying relationships with fecundity are poorly described, weak or based on few data.


4-Oxo-β-ionone was synthesized in one step efficiently fromβ-ionone with molecular oxygen by using N-hydroxyph-thalimide combined with Co(AcAc)_2,and it was characterized by ~1H-NMR,~(13)C-NMR,GC-MS,IR,and element analysis.


Abstract : This report summarizes the preliminery tests of valveless pulsejet engines for application as helicopter tip mounted power plants. These tests were conducted with 4 inch diameter and 5-1/2 inch diameter engines on the Cornell Aeronautical laboratory 10-foot rotor whirling arm test stand at tip speeds up to 600 fps. Major emphasis has been placed upon evaluating the effect of exhaust to inlet area ratio and fuel injecion system upon engine performance and stability over the test speed range. These tests have indicated that stable resonant operation could be sustaised throughout the 0-600 fps tip speed range. Available thrusts of up to 21% lbs. have been obtained with the 5-1/2 inch diameter engine with thrust specific fuel consumptions somewhat less than 7 lbs. fuel per hour per pound thrust at 600 fps tip speed.


WHEN your chairman, Mr. Jackson, asked me to supply a title for the Presidential Address, I could think of no name short enough and suitable for these random remarks, à bâtons rompus for half an hour. Professor Turner gave the Mathematical Association an account of some new methods in calculation, found successful for Halley's Comet; and Ray Lankester held forth in the afternoon on his perennial subject of the place of Greek in education, about which Turner has given you his say on a previous occasion. I must avow myself at the outset in complete disagreement with their opinion, as in Greek we come to the bedrock of all our knowledge in history, literature, science, and art. Greek is the lighthouse to guide us out of barbarism to the human ideal.


This study was carried out to investigate the effect of eating behavior, physical status and tendency of eating disorder on the right eating habit. The subjects of this study were 324 middle school students and 340 high school students in Osan city GyeongGi province. The average of weight and height in the middle and high school students were 48.7kg, 160.0cm and 56.8kg, 164.8cm respectively. In PIBW values, 92.9% of middle school students and 99.1% of high school students were almost close to the average. The 28.5% of high school and 21.5% of middle school students were aware of themselves as overweight. The risk of eating disorders in high school students(16.4%) were higher than that in middle school students(4.9%). Moreover, the risk of eating disorders in girls high school students(19.3%) was significantly higher than those of middle school students(5.2%) (p


ABSTRACT: This research is to investigate and evaluate the implementation of special autonomy as it is regulated in the act No. 11, 2006 on the Government of Aceh. Data far this research was gathered by library resources, such as primary, second, tertiary law resources. Field study by interviewing some parties who were related this research was done in order to support secondary resources. The research findings show that the special autonomy in Aceh did not effectively implementation yet, this factor was caused by procedures of implementation (peraturan pelaksanaan) was not fulfilled by the center government. Special Autonomy Implementation in Province Aceh based on the act Number 11 of 2006


Here, we describe an improved high‐speed CE (HSCE) system using a short capillary and translational spontaneous sample injection. Several important factors for consideration in system design as well as various factors influencing the performance of the HSCE system were investigated in detail. The performance of this HSCE system was demonstrated in electrophoretic separation of FITC‐labeled amino acids. Under optimized conditions, baseline separation of eight amino acids and FITC were achieved in 21 s with the plate heights ranging from 0.20 to 0.31 μm, corresponding to a separation rate up to 20 700 theoretical plates per second. The separation speed and efficiency of the optimized high‐speed CE system are comparable to or even better than those reported in microchip‐based CE systems.


BACKGROUND
The aim of this study was to measure the effect of simulating two different loads on maxillary incisors displaying eight morphological types of non-carious cervical lesions, unrestored and restored with an adhesive restoration, by quantifying the stress distributions generated using finite element analysis.

METHODS
Virtual models of maxillary incisors were generated using the CAD software (RhinoCeros). After composing virtual dental and supporting structures with and without non-carious cervical lesions, each model was meshed using a control mesh device (ANSYS Finite Element Analysis Software). All of the virtual models were subjected to two load types, oblique load and vertical load, to simulate occlusal forces of 100 N each. Comparisons were made between simulated teeth with non-carious cervical lesions, with and without composite resin restorations, and a simulated sound tooth. Data summarizing the stress distributions were obtained in MPa using von Mises criteria.

RESULTS
Oblique loading on simulated non-carious cervical lesions resulted in greater stress concentration compared with vertical loading, and non-carious cervical lesions with acute angles displayed higher stress concentrations at the depth of the lesion. Restoring the lesions with an adhesive restoration, such as composite resin, appeared to overcome this stress concentration.

CONCLUSIONS
Restoring NCCLs with adhesive restorative materials, such as a nanohybrid composite resin, appears to recover the biomechanical behaviour similar to sound teeth.


University managements have the responsibility to ensure that their employees' work-life balance is improved, not only for the mere compliance of laws and statutes but rather to mitigate the pitfalls of high turnover and high health care costs associated with work-family conflicts, which are proven to be financially disadvantageous over putting into place a healthy human resources recruitment and retention strategy. The present study investigates the influence of work life balance on employee performance in education sector of Pakistan. The study also investigates the moderating effect of transactional leadership on relationship between work life balance and employee performance. The study used sample of 150 respondents from eight universities of Islamabad and Rawalpindi. The regression and moderation analysis are performed by using the SPSS 22. The findings of study reveal the work life balance has significant positive effect on employee performance. The results also present that transactional leadership has significant moderating effect. The study recommends that management of universities should consider the effect of work life balance while making polices about leave and working load etc. The findings of study have important policy implications for policy makers and government to increase the employee performance. Keywords: Work Life, Performance, Pakistan, SPSS, Transactional


"The Enlightenment", a broad and complex phenomenon, is a vital part of the history of European culture. It shaped intellectual life from the middle of the 17th century until the early 19th century and in its shadows many intellectual battles are still being fought. The contributors to this original and provocative book subject both the Enlightenment and subsequent responses to it to critical scrutiny. Committed to an interdisciplinary approach, the contributors are drawn from a variety of disciplines - art history and theory, government, history, language and linguistics, literature, philosophy, sociology, music and economics. They present a distinctively broad and polemical view of the Enlightenment, enhanced by the imaginative use of a number of illustrations. The essays demonstrate the continuing importance of the Enlightenment to a range of current debates on such issues as human rights, nature, economics, and colonialism. They focus on England, Scotland, France and Germany, and their innovative approach does justice to the complexity of figures like Voltaire, Ferguson, Kant, Burke and Rousseau.