The objective of the method was to develop a simple, rapid, sensitive, precise, accurate and validated Ultra Performance Liquid Chromatographic (UPLC) method for the simultaneous estimation of Sofosbuvir and Velpatasvir in tablet dosage form. Chromatographic separation was achieved on an acquity UPLC HSS C18, 2.1 × 100 mm, 1.8μ column with a mobile phase composed of orthophosphoric acid buffer and acetonitrile in the ratio of 45:55 at a flow rate of 0.2 ml/min and 1 μl injection volume. The effluents were detected at a wavelength of 250 nm using TUV detector. The retention times of Sofosbuvir and Velpatasvir were found to be 1.425 and 1.767 min respectively. The method was validated with respect to specificity, accuracy, linearity, precision, robustness. The correlation coefficient for Sofosbuvir and Velpatasvir were found to be 0.9992 and 0.9995 respectively. Recovery of Sofosbuvir and Velpatasvir in formulation was found to be 99.48% and 99.6% respectively. Due to simplicity, high precision and rapidness the method can be successfully applied for simultaneous estimation of Sofosbuvir and Velpatasvir in combined dosage form. INTRODUCTION: Sofosbuvir (SBR), chemically Isopropyl (2S) -2 -[[[(2R, 3R, 4R, 5R)-5-(2, 4dioxopyrimidin -1 -yl) -4-fluoro -3-hydroxy -4methyltetrahydrofuran -2 -yl] methoxy-phenoxy phosphoryl]amino] propanoate is a nucleotide prodrug that potently inhibits genotype 1 to 6 hepatitis c virus (HCV) RNA replicons in-vitro and has demonstrated high sustained virologic response (SVR) rates 1, 2, 3 . The structure of Sofosbuvir was shown in Fig. 1. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.9(11).4764-69 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.9(11).4764-69 Velpatasvir is a novel HCV non-structural protein 5A (NS5A) inhibitor that is being developed in combination with Sofosbuvir and other direct acting antivirals for the treatment of HCV infection. The chemical name of Velpatasvir is Methyl {(1R)-2[(2S,4S) -2-(5 -{2-[(2S, 5S) -1-{(2S)-2-[(methoxy carbonyl) amino] -3 -methylbutanoyl} -5-methyl pyrrolidin-2-yl] -1, 11 -dihydro [2] benzopyrano [4',3':6,7] naphtha [1,2-d] imidazol-9-yl} -1Himidazol-2-yl)-4(methoxymethyl) pyrrolidin-1-yl]2-oxo-1-phenylethyl}carbamate 4 . The structure of Velpatasvir was shown in Fig. 2. Due to the additive antiviral interaction and lack of crossresistance observed in-vitro between Sofosbuvir and Velpatasvir, the administration of these two drugs as a film-coated tablet is expected to provide significant antiviral activity and a favourable resistance profile.


Over the years, SB research group has carried out investigations at two Romans archaeological sites with thermal baths; in Serbia in 2013 and more recently the Laško area in Slovenia. In both cases we found the positioning of the Roman baths is to be much more than a purely random act. It is believed that empirical knowledge of thermal waters (orgininating from the Etruscans) was utilised by the soothsayers of the Roman Empire, the augers, to locate the baths to obtain the maximum benefit from there natural wellbeing properties. Using advanced devices we added weight to this hypothesis through use of archaeoacoustic methodology.


In this paper, for continuous, linearly-controllable quadratic control systems with a single input, an explicit, constructive method is proposed for studying their Brunovsky forms, initially studied in (W. Kang and A. J. Krener, Extended quadratic controller normal form and dynamic state feedback linearization of nonlinear systems, SIAM Journal on Control and Optimization, 30:1319- 1337, 1992). In this approach, the computation of Brunovsky forms and transformation matrices and the proof of their existence and uniqueness are carried out simultaneously. In addition, it is shown that quadratic transformations in the aforementioned paper can be simplified to prevent multiplicity in Brunovsky forms. This method is extended for studying discrete quadratic systems. Finally, computation algorithms for both continuous and discrete systems are summarized, and examples demonstrated.


Acknowledgments Introduction List of Abbreviations Part I. The Roots of Sectarianism 1. Governance 2. The Long Shadow of the Iranian Revolution Part II. Bahrain 3. Debating Participation: The Bahraini Shia and Regional Influences 4. Sectarian Balancing: The Bahraini Sunnis and a Polarized Parliament 5. Into the Abyss: The Pearl Roundabout Uprising and Its Aftermath Part III. Saudi Arabia 6. Loyalties Under Fire: The Saudi Shia in the Shadow of Iraq 7. Under Siege: The Salafi and Regime Countermobilization 8. Waving Uthman's Shirt: Saudi Arabia's Sectarian Spring Part IV. Kuwait 9. Renegotiating a Ruling Bargain: The Kuwaiti Shia 10. Tilting Toward Repression: The Sunni Opposition and the Kuwaiti Regime 11. A Balancing Act Goes Awry: Sectarianism and Kuwait's Mass Protests Conclusion Notes Bibliography Index


The present invention discloses a touch display panel, touch display device includes a TFT array substrate and the color filter substrate disposed opposite; the TFT array substrate comprising: a plurality of touch drive lines; a plurality of touch sensing lines; a plurality a touch TFT, the source and drain of the TFT touch in a touch driving line connected to the electrically and touch the other of the source and drain of the TFT in touch with the sensing line is electrically connected; the color filter substrate comprising: a color filter disposed on the substrate facing the plurality of conductive pillars on a surface of the TFT array substrate, and the conductive pillar TFT provided corresponding to the touch, the control TFT touch-channel current. The present invention discloses a touch panel display, the touch display of a TFT array device compatible with existing pixel array structure and process, no additional process steps; Further, without waiting for detection, power consumption is small.


BACKGROUND: The cleft lip (CL) and palate are common orofacial congenital abnormalities observed in Indian population. Various predisposing factors contribute to this condition. PURPOSE: The purpose is to assess the most common type of CL and palate and to study predisposing factors associated with its development. MATERIAL AND METHODS: This cross-sectional prospective study was carried in 80 patients with CL and palate. A detailed history was recorded in predesigned pro forma. The occurrence of different types of CL and palate with predisposing factors were assessed. RESULTS: Out of 80 patients, 18.8% of patients had only CL, 46.2% had unilateral CL with palate (UCLP), and 35% had a bilateral CL with palate (BCLP). CL and palate were observed more in males. The left side of the lip was more affected than the right side. Low socioeconomic status patients had more incidences. Advanced maternal age, more than 35 years, was the most common predisposing factor 62.5%. Consanguineous marriage of parents was the second-most predisposing factor observed in 40% of cases. Breastfeeding habit was observed in 73.3% of CL patients, 25% in UCLP patients, and 17.2% in BCLP patients. CONCLUSIONS: Males were more commonly affected by CL and palate with the left side predominance. Advanced maternal age above 35 years was the most predisposing factor followed by consanguineous marriage of the parents.


The role and significance of background music and sound commentary in multimedia system is described in this paper,a dualslider volume control to realize background music and sound commentary of multimedia is introduced in detail,comparing with some usual voice control method,it is easy to control sound,and,its interface is simple.


Replicative senescence of cells in culture is associated with highly reproducible DNA methylation (DNAm) changes at specific sites in the genome. Thus far, it is largely unclear if these epigenetic modifications are directly regulated, or if they are randomly evoked by other chromatin changes during long-term culture. We have identified CG dinucleotides (CpGs) that become continuously hyper- or hypo-methylated in the course of culture expansion of mesenchymal stem cells (MSCs) and other cell types. These modifications provide a biomarker for replicative senescence and correlate with the number of passages in vitro. During reprogramming into induced pluripotent stem cells (iPSCs) senescence-associated DNAm is reversed simultaneously with pluripotency-associated DNAm changes. Bisulfite barcoded amplicon sequencing (BBA-seq) demonstrated that upon passaging the DNAm patterns of neighboring CpGs become more complex without evidence of continuous pattern development. Notably, BBA-seq of hairpin-linked DNA molecules demonstrated that many CpG dyads are methylated only on the forward or the reverse strand. This hemimethylation was conserved over many passages, indicating that it was not due to insufficient maintenance of DNAm patterns. Circularized chromatin conformation capture (4C) of senescence-associated CpGs revealed reproducible changes during senescence without evidence for preferential interaction between CpGs that become either hyper- or hypomethylated. Taken together, senescence-associated DNAm fluctuates stochastically at specific sites in the genome. Strand-specific DNAm and reproducible changes in 4C indicate that epigenetic modifications of these CG dyads are not regulated in a targeted manner but rather caused by passage-specific higher order chromatin conformation states.


Molecular beam epitaxy (MBE) at high growth rate more than twice compared with the conventional rate was investigated for ZnSe layers and related laser structures by using polycrystalline compounds as source materials. A clearly-streaked (2 x 1) pattern indicating Se-stabilized surface was observed by reflection of high-energy electron diffraction during the growth of ZnSe:N layers at 260 - 360 degrees Celsius with around 2 micrometer/h. Full width at half-maximum of double crystal x-ray rocking curve was as narrow as 85 arc sec for a 6.5- micrometer-thick layer with mirror-like surface morphology. ZnCdSe/ZnSSe/ZnMgSSe separate confinement heterostructure lasers operated at room temperature were obtained with a time required to grow of 80 min. II-VI layers grown by the rapid compound-source (CS) MBE had high crystalline quality comparable to that of the layers grown at the conventional growth rate. CSMBE has the surface migration enhancement effect at the growth front due to high kinetic energy of source molecules. The CSMBE technique solved the problem of low productivity for the conventional II-VI MBE growth.


1. In principle, empirical determination of effective temperature of a red giant star is possible if apparent angular diameter and apparent bolometric magnitude are known. The present situation is summarized in Fig. 1 in which empirical effective temperatures based on bolometric corrections, now well established (Johnson 1965), and available angular diameters are plotted against R-1 color indexes. Generally, the differences of the effective temperatures determined from angular diameters by different observers are several hundreds degrees for the same star and as large as 1000 °K for an extreme case (a Herculis A). Evidently, another argument should be required toj establish the effective temperature scale of red giant stars. For this purpose, one possibility could, be to apply model atmospheres. Although some difficulties are well known in this approach in cool stars, it can be shown that the present state of art is such that model atmosphere method can at least differentiate between models based on largely different effective temperatures if properly been applied to an analysis of observed spectral energy distributions. 2. The above noted possibility is examined by the use of grids of line-blanketed model atmospheres.*) In Fig. 2, the observed spectral energy distribution of a Tauri (K5111) is compared with the predicted ones from models.**) The model of Teff=3800 °K can be rejected, since the observed flux is too large near the flux peak around 0.8 p as compared with the predicted line-blanketed flux (stepwise solid line) and moreover exceeds the line-blocking-free continuum (thin continuous line) which is the maximum possible flux expected from this model. The model of Teff=4200 °K can also be rejected since the predicted flux is too large as compared with the observed


In this work, rutile-phase TiO2 nanoparticles (npTiO2) are embedded within a Spin-On Glass oxide matrix (using a simple and economic Sol-Gel method) and the final TiO2/SiO2 mixture is directly deposited on stripes of aluminum so that the electronic, physical, chemical and photocatalytic characteristics of the final dielectric structure are obtained and correlated when irradiated with UV-Vis light sources. The I-V characteristics of this simple structure present a reduction in its total resistance when irradiated with UV light (compared to dark conditions), thus revealing a very simple photoresistor with relatively-low quantum efficiency. Keywords-TiO2; nanoparticles; photoresistor; UV light; photogeneration; sol-gel processing; metal-semiconductor.


In recent years,many ads.with flower-vase-like female or good-mother-and-wife-like female images,sex implication and wulitou style in them which caused many controversies between profit and cultural duty.Dialectics say that the unity of opposites is the fundamental law of the universe.Thus profit and cultural duty of ads can be integrated.Two ways can help us reach the unity:the first one is market adjusting.The second one is macroscopic control


Summary Electron paramagnetic resonance (e.p.r.) studies of T(50G) of poly(phenylacetylene) have been carried out at X-band as a function of sp in probe size over a wide range of temperatures.It was found that T(50G) increased wit h increasing probe size.The polymer glass transition temperature T(g), determin ed from the break on the plot of ln T(R) versus 1/T for tempone in poly(phenylacetylene), was 296 K.The apparent activation enthalpy for the T(g) relaxation process increased with increasing probe size, while the segmental size of the polymer appea red to be independent of the nitroxide used, and has a range of 898-922 angstrom 3.The segmental volume measured by the spin probe technique is in excellen t agreement with the volume of 970 angstrom 3 of 10 repeat units on an average cha in based on number-average molecular weight of 960.Thus our results showed tha t there are 17-20 backbone atoms in the segment of poly(phenylacetylene).Assuming the polymer segment to be of spherical shape, the diameter of the sphere was fou nd to have a range of 11.7-12.4 angstrom.


This paper applies the stochastic frontiers model proposed by Battese and Coelli (1995) to simultaneously estimate the stochastic cost function and equation of inefficiency for 19 listed highway enterprises in China from 2001 to 2005. The major findings are as follows: The costal location provides a significant cost efficiency advantage than the inland. An increase in scale of the enterprise significantly improves cost efficiency, showing the scale of economy. The average cost efficiency scores are low but generally improving in the sample period.


Black for a Day takes on "white-to-Black" racial passing through five readings of first-hand accounts. While it would be simple enough to bring up such examples of passing as nothing more than farc...


This Article base the testing analyse introduces to bring the influence of disposal retarders in marshalling yard after the track of over loading hump rolling, and it also put forward that we should adapt this new change to alteration and amelioration the existence speed control equipments and operation mode.


Implantation of Ti and C into stainless steel discs of Types 304, 15-5 PH, Nitronic 60 and 440C has previously been reported to reduce wear depths by up to approx. 85% and friction by approx. 50% in unlubricated pin-on-disc tests. Our earlier studies relating microstructure to friction and wear results in Type 304 are first summarized: these indicate that the improvements in the surface mechanical properties are due to an amorphous surface layer, similar to the amorphous layer observed in pure Fe implanted with Ti and C. We have now examined the other three implanted steels and found similar amorphous layers. These results strongly suggest that the amorphous surface alloy is responsible for reduced friction and wear in all the steels. 6 figures.


BACKGROUND: Blood centers and hospital transfusion services are challenged with maintaining an adequate platelet (PLT) inventory to minimize the number of outdated units without risking a major shortage. A novel approach to inventory management was established at our institution through a collaboration between the Stanford University Medical Center (SUMC) Transfusion Service, the Stanford Blood Center (SBC), and the Department of Management Science and Engineering.


Abstract In their numerical analysis of convection driven by centrifugal buoyancy in a rotating cylindrical annulus Or and Busse (1987) found that sideband instabilities played an important role. These instabilities correspond to a finite value of the Floquet parameter d and have the tendency to modulate the periodic convection pattern. Since the Galerkin method is not suitable for the study of the convection flow as the sideband instabilities with their small Floquet wavenumber d grow to finite amplitudes, it was suggested (Busse, 1986) that amplitude equations for the principal modes are investigated to gain at least a qualitative understanding of the problem. The amplitude equations which retain interaction terms up to the cubic order of the amplitude appear to give a fairly accurate description of the symmetric convection columns (Busse and Or, 1986) and of the mean flow solution occurring at higher Rayleigh numbers (Lin et al., 1989). The plan was thus conceived to extend the analysis to the case of ...


Career planning is a long-term system project,which plays an irreplaceable role in enhancing the employment ability of college students and leading them to consider and plan their life goals.Beginning with the guiding role and practical significance of career planning,this paper introduced the implementing scheme and concrete steps of the guidance of career planning in colleges and universities under new situation.


In recent years, atom probe tomography (APT) has been increasingly used to study minerals, and in particular the mineral zircon. Zircon (ZrSiO4) is ideally suited for geochronology by utilising the U-Th-Pb isotope systems, and trace element compositions are also widely used to constrain petrogenetic processes. However, while standard geoanalytical techniques provide information at micrometer scale lengths, the unique combination of chemical/isotopic sensitivity and spatial resolution of APT allows compositional and textural measurements at the nanoscale. This interlaboratory study aims to define the reproducibility of APT data across research facilities and assess the role of different aspects of the atom probe workflow on reproducibility. This is essential to allow correct evaluation of APT results and full utilization of this emerging technique within the geoscience community. In this study, nine samples from the same homogeneous, GJ-1/87 zircon reference grain were sent to nine APT institutes in Germany, the UK, USA, Canada and Australia. After preparing the sample out of a selectioned slab, each institute conducted three different rounds of APT analyses: using (i) unconstrained analysis parameters, (ii) pre-defined analysis parameters, and (iii) interpreting and quantifying a provided dataset. Data such as the measured elemental composition, acquisition parameters, or mass spectrum peak identifications, were recorded and analyzed. We observe a significant variation in the measured composition across this interlaboratory study as well as the number of trace elements identified. These differences are thought to directly result from the user's choice of atom probe data analysis parameters. The type of instrument does not seem to be a critical factor. Consequently, comparison of absolute trace element concentrations on zircon using APT between laboratories is only valid if the same workflow has been ensured. https://doi.org/10.1016/j.chemgeo.2018.07.031 Received 20 October 2017; Received in revised form 27 June 2018; Accepted 26 July 2018 ⁎ Corresponding author at: School of Aerospace, Mechanical, Mechatronic Engineering, University of Sydney, NSW 2006, Australia. E-mail address: email@example.com (A. La Fontaine). Chemical Geology xxx (xxxx) xxx–xxx 0009-2541/ © 2018 Elsevier B.V. All rights reserved. Please cite this article as: Exertier, F., Chemical Geology (2018), https://doi.org/10.1016/j.chemgeo.2018.07.031


The invention provides an embedded combustion device of a boiler, which belongs to the technical field of boiler fuel equipment and is used for solving the problem that the thermal efficiency of the conventional boiler combustion device is not high. The embedded combustion device of the boiler comprises a combustion body I with a first combustion chamber, a combustion body II with a second combustion chamber and a combustion body III with a third combustion chamber, wherein the first combustion chamber is communicated with the second combustion chamber through a diversion pipe I; the second combustion chamber is communicated with the third combustion chamber through a diversion pipe II; the combustion body I is provided with a feeding hole of which the inner end is communicated with the first combustion chamber; the outer end of the feeding hole extends out of a boiler shell and is communicated with the outside of the boiler shell; the combustion body III is provided with a smoke outlet which is communicated with the third combustion chamber; the smoke outlet is provided with a draught fan which can be used for controlling flame to flow along the diversion pipe I and the diversion pipe II; and when the draught fan is started, the second combustion chamber can be used for performing cyclone dust removing on flame therein. The embedded combustion device has the advantages of complete combustion, high thermal efficiency and the like.


We study the stochastic dynamics of a renewable resource harvested by a monopolist facing a downward sloping demand curve. We introduce a framework where harvesting sequentially affects the resource's potential to regenerate, resulting in an endogenous ecological regime shift. In a multi-period setting, the firm's objective is to find the profit-maximizing harvesting policy while simultaneously detecting in the quickest time possible the change in regime. Solving analytically, we show that a negative regime shift induces an aggressive extraction behaviour due to shorter detection periods, creating a sense of urgency, and higher markup in prices. Precautionary behaviour can result due to decreasing resource rent. We study the probability of extinction and show the emergence of catastrophe risk which can be both reversible and irreversible.


Market-based regulatory instruments hold the promise of correcting market failures at least cost. However, evidence on their efficacy remains scarce. We evaluate the European Union Emissions Trading Scheme (EU ETS) - the world's first and largest market-based climate policy. Using administrative data on almost 4,000 French manufacturing firms, we estimate that the EU ETS induced regulated firms to reduce carbon dioxide emissions by 8-12% compared to unregulated firms after the Pilot phase, a necessary condition for climate change mitigation. These reductions account for 26% of the concurrent decline in aggregate industrial emission in France. We do not estimate any negative effects on the scale of production; instead we find that firms reduced the emissions intensity of value added by making targeted investments. We find no evidence that firms outsourced production to unregulated firms or markets. Collectively, these findings suggest that the EU ETS induced global emissions reductions, a necessary and sufficient condition for mitigating climate change.


This study investigated the anti-inflammatory effects of wheat germ oil (WGO) on RAW 264.7 cells. It was shown that WGO had no cytotoxicity against the treated cells or negative effect on their proliferation. WGO suppressed nitric oxide (NO) secretion considerably and had inhibitory effects on the production of LPSinduced NO and pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β). In particular, the IL-6 and TNF α inhibition activities were over 90% at 100 μg/ml concentration of the oil. WGO also inhibited the LPSinduced expression of cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-kappa B (NF- κB), and reduced the expression of phosphorylated ERK and JNK. Moreover, the croton-oil induced edema in mouse ears was reduced by WGO, and no mortalities occurred in mice administered 5,000 mg/kg body weight of WGO over a 2-week observation period. In conclusion, these results provide evidence for the antiinflammatory effect of WGO that likely occurs via modulation of NF-κB and the JNK/ERK MAPK signaling pathway.


We present a systematic study to investigate the effects of nonframework cations and the role of phonon scattering mechanisms on the thermal transport properties of zeolite LTA, via experiment and semiempirical lattice dynamics calculations. Our study is motivated by the increasing interest in accurate measurements and mechanistic understanding of the thermal transport properties of zeolite materials. The presence of a nanostructured pore network, extra-framework cations, and tunable framework structure and composition confer interesting thermophysical properties to these materials, making them a good model system to investigate thermal transport in complex materials. Continuous films of zeolite LTA with different nonframework cations (Na+, K+, and Ca+2) were synthesized and characterized. The thermal conductivity was measured using the three-omega method over a wide range of temperature (150–450 K). These are the first thermal conductivity measurements performed on bulk LTA, so they are more accurate tha...


In the sensor substrate, and a method of manufacturing the display device having the same, the sensor substrate comprises a sensing transistor, and a switching transistor provided on the base board provided on the base substrate, said base substrate. The sensing transistor has a first gate electrode, the first gate electrode photoreaction pattern provided on a first source / first drain electrode spaced apart on said optical response pattern, between the first source electrode and the optical response pattern the first oxide comprises a second oxide semiconductor pattern interposed between the semiconductor pattern, and the first drain electrode and the optical response pattern interposed. And it said switching transistor includes a second gate electrode, wherein the third oxide semiconductor pattern, and wherein a second source / second drain electrodes spaced apart on the third oxide semiconductor pattern provided on the second gate electrode.


Sobrasada sobrasada pate low fat and its preparation process. The present invention relates to a light sobrassada pâte sobrassada having a fat content of about half a traditional sobrassada paste. Additionally, it is a product that provides about 50% fewer calories, besides having a reduced saturated fat and cholesterol for products of traditional composition content. Furthermore, the present invention also relates to the process for obtaining said sobrassada sobrassada pâte.


The history of the Section on Pathology and Physiology reveals changes of name and shifts of emphasis that reflect the developments in both sciences since 1859. The recognition of pathology as a specialty followed the development of microscopy, and the formal training of specialists in pathology began in 1886. The rapid developments of the past 50 years justify certain predictions as to the future. Laboratory tests, largely mechanized to increase accuracy and facilitate handling of results, will be adapted to extensive screening programs. Pathology, while maintaining its status as a basic science, will emphasize its application to patients in hospitals, and medical students will be more regularly assigned to clerkships in clinical pathology before beginning their regular ward service.


To obtain the quality of water more economically and flexibly, it improves the traditional node optimization layout method — dynamic proximity degree method from the perspective of unmanned ship. Based on considering the data correlation and time factors of the monitoring nodes, and considering the influence of the relative position relationship between the nodes on the length of the inspection path, a simple and efficient genetic algorithm is designed to further optimize the node selection with a faster convergence speed. The water quality monitoring experiment of lake in the university was carried out by an unmanned surface vehicle and MATLAB platform. The results show that the improved dynamic proximity algorithm retains the representativeness of the nodes to the water quality and greatly shorts the cruise path of the ship. In the optimization experiment of 14 nodes, compared with the traditional node selection method, the path length is shortened by 14.85% on average.


The corrosion behavior of Al-0.63Mg-0.28Si alloy under MgCl_2 solution drops with initial concentration of 0.05 mol/L~0.3 mol/L and volume of 6μL in the environment of relative humidity(RH) 75%and RH 33%were studied by using Kelvin Probe.In these two environments,because the water in the drop is evaporated,a thin MgCl_2 solution layer with a diameter of about 2.9~3.2μm forms on the alloy surface.As the open circuit potential(OCP) baseline keeps stable at -0.3~-0.5 V_(vs SHE),there exists potential noise that the OCP repeatedly exhibits a sudden decrease and then immediate recovery,which is associated with initiation and re-passivation of metastable pits with diameter less than 3μm.When the OCP baseline decreases slowly to -0.7~-0.8 V and keeps stable low,stable filiform-like corrosion occurs and develops.In the environment of RH 33%,only metastable pitting corrosion occurs within 24 h.In the environment of RH 75%,as the initial MgCl_2 concentration is 0.3 mol/L and 0.2 mol/L,the main corrosion form is metastable pitting corrosion.As the initial concentration is reduced to 0.1 mol/L,stable filiform-like corrosion always occurs on the drop edge and grows outward.As the initial concentration is further decreased to 0.05 mol/L,the likelihood of stable corrosion is lowered,and the main corrosion form is metastable pitting corrosion within 24 h.The number of metastable pits every unit time is increased with RH of the environment.Meanwhile,in environment of the same RH,it is increased with the decrease in initial concentration.


It is not only an effective way to attract social unused fund so as to push new countryside construction of Socialism,but also an important act by lottery market and giving play to second finance,which has character of Pareto Improvement.The problem is probed in the article.


The article discusses the technology of working with the voice of variety vocalists in the preparation of students in the field "Musical Variety Art". The author refers to such an important component of the singer's voice as timbre, shows how this quality of sound production is formed, gives examples of voices with different and recognizable timbres, and considers exercises for developing the timbre basis of the voice, strengthening it and developing its specificity. The author examines the key foundations that form the timbre color of the voice, i.e. breathing and the position of the larynx, and analyzes the process and the result of using technologies for working with voice. The article may be in demand by specialists - variety vocal teachers, as well as by those who are engaged in vocal training of actors.


Tethered trailer vehicle is a nonprofessional tractor that drags an unpowered vehicle with rope. In this paper, a nonlinear dynamic model of the tractor is developed. With the Dugoff's tire model. A new nonlinear tethered tractor-trailer model is created to simulate critical parameters. A trailer front-wheel steering feedback control strategy is derived in order to improve stability and trajectory tracking feature the comparison of the simulation results for tension of the traction rope, the trajectory following resistance, and the handling stability clearly demonstrates the efficacy of the proposed control strategy.


The following is excerpted from Finding the Hidden-Ball Trick: The Colorful History of Baseball's Oldest Ruse, by Bill Deane, scheduled to be published by Rowman & Littlefield in Spring 2015.Ifirst started "collecting" hidden-ball tricks in the 1980s. Employed as Senior Research Associate for the National Baseball Library from 1986-1994 and working on my own projects after hours, I spent hundreds of hours a year doing research for myself and others. Inevitably, I stumbled across interesting tidbits which had little or nothing to do with what I was working on, and I kept various lists based on these findings. Many of these feats, like three-pitch innings, and scoring from first base on a single, turned out to be not as uncommon as I thought. But the hidden-ball trick held up as a rare and remarkable event, roughly as uncommon as a no-hitter.My project blossomed thanks to the internet and considerable help from others. To date, I have documented 264 successful executions of the HBT in the major leagues.The New Dickson Baseball Dictionary defines the hidden-ball trick as "a time-honored legal ruse in which a baseman [I'd say "infielder"] conceals the ball and hopes that the baserunner believes it has been returned to the pitcher. When the runner steps off the base, he is summarily tagged out with the hidden ball."1 SABR member Eric Sallee gives a good explanation of what is required for the play to be successful, saying "the sun, the moon, and the stars all have to be in alignment in order for it to work:1. Play cannot be 'dead,' i.e., time is not 'out';2. The pitcher cannot be touching or straddling the pitching rubber;3. The umpire has to be alerted or paying attention;4. A bonehead runner must be willing to take a lead off a bag before the pitcher toes the slab; and5. The bonehead runner's teammates and base coaches all have to be asleep, as well."The hidden-ball trick is almost as old as baseball itself. It has been said to date back to Harry and George Wright of the 1869 Red Stockings, but 19th century baseball expert Peter Morris scoffs at the notion of that team resorting to such deceptive ruses. Another source credits National Association utilityman Tom Barlow with the innovation. The earliest HBT I have documented occurred on May 20, 1872, in a Philadelphia-Baltimore NA game; it was described as an "old trick" as early as 1876. In any case, it dates back more than 140 years, and has happened to end games and to complete triple plays. It once resulted in two arrests, another time cost a Hall of Famer a managing job, and it even happened in a World Series. With TV monitors in the clubhouses and professional coaches at the bases, the play was still pulled off twice in 2013.Following are accounts of 10 successful pre-1 920 executions of the hidden-ball trick:Date: June 17, 1884Teams: Buffalo Bisons vs. Chicago White Stockings (NL)Perpetrator: Buffalo first baseman Dan BrouthersVictim: Billy Sunday, ChicagoAccording to The Sporting Life, "Brouthers, in one of the games with Chicago last week, worked a very old trick on Sunday. The latter had made a good base hit and was safe on first. The guileless Daniel had thrown the ball back to [pitcher Billy] Serad (in his mind), when Sunday slipped off the bag. Dan jerked the ball from under his arm and touched him out before the Chicago right fielder knew what happened. Any player stupid enough to be caught in that manner deserves a fine."2 Buffalo won the game, 8- 7 in 10 innings. Brouthers was on his way to the Hall of Fame; Sunday was on his way to a long career as an evangelist.Date: September 28, 1893Teams: Pittsburgh Pirates vs. New York Giants (NL)Perpetrator: Pittsburgh first baseman Jake BeckleyVictim: John Montgomery Ward, New YorkAccording to the New York Sun, "It was in the ninth inning and Ward had made a single. Of course John was tickled to death and did not observe that the ball was passed to Beckley. …


In this paper, we report the potential of the doping-less (DL) double gate field effect transistor (DL-DGFET), for ultra low power (ULP) subthreshold logic applications. We demonstrated that the proposed DL-DGFET do not require any doping from source to drain region and it can perform significantly better than highly doped junctionless (JL) and abrupt S/D inversion-mode (IM) DGFETs. The DL-DGFET achieves 1.8X and 2.75X cutoff frequency (fT), 1.7X and 3X maximum frequency of oscillation (fMAX) along with 10.5 and 18.6 dB improvement in intrinsic voltage gain (AVO) in comparison to conventional JL and non-underlap FETs, respectively. Simulation results revealed that the DL-DGFET alleviates the inherent trade-off between gain and bandwidth of nanodevices by 6X improvement in gain frequency product (GFP) over highly doped JL-DGFET due to significant reduction in parasitic capacitances.


The smallholder irrigation sector in Kenya is considered inadequately developed. The study views unawareness of critical success factors in the smallholder irrigation sector as contributing to poor performance of smallholder irrigation projects. Consequently, the study investigated influence of farmer capacity building in institutional linkages on performance of smallholder irrigation projects in Migori County, Kenya. The study embraced a pragmatic view of philosophy, and used cross sectional and correlation research design. The target population was 2815, and comprised farmers drawn from fifteen smallholder irrigation projects that receive water from River Kuja through Lower Kuja Project. The sample size was 341. The study used systematic random sampling procedure to draw the sample, and collected data using questionnaire. Data was analysed using descriptive and inferential statistics. The study established that farmer capacity building in institutional linkages has a significant influence on performance of smallholder irrigation projects (r = 0.803, R2 = 0.645, F (5, 331) = 120.254 and p < 0.000 < 0.05). Thus, the study recommends that Migori County Government come up with policies that link smallholder irrigation projects in Lower Kuja Project to institutions that provide land ploughing services, certified seeds and fertilisers, control of crop pests and diseases, transportation of farm produce and marketing of farm produce.


To evaluate whether infants with complex congenital heart disease (CCHD) have an increased risk of impaired quality of motor behavior and delayed motor milestones.


The higher occupation education initiated skills teaching to cultivate high-quality skilled talents,whose teaching process was to promote the combination of theoretical teaching and practical teaching.In such a combination process,how to make the teaching was not only simple theory and practice—learning theory practice,but also the embodiment of both a organic combination,in learning to operate in expression,communication,and there were new ideas and new understanding of the generation to enrich personal experience and participate in the operation,decision-making,and seek common zoned in order to improve the ability to change the status quo and further confidence.A useful attempt during the participating teaching method was provided,taking Fluid Transport courses teaching as an example.


The Coming AUTH project is about the enrichment and deduplication of authority data in SBN catalogue; the project will have both a professional procedure and a social one. Thanks to the cooperation between ICCU and AIB Lazio, the first one involves young professionals, and the choice of the data to be enriched will be decided later on.

The second one will take advantage of services like Wikimedia Mix'n'match, and will be open to everyone; anyone could register and then try to match the names of different entities.In doing so, we will be able not only to clean and enrich the authority data, but also to improve the visibility of the SBN catalogue and the participation of users to its improvement.


The issue of teaching pronunciation has been severely neglected after the first year of most university foreign language (FL) courses. Moreover, research examining factors affecting the acquisition of the second language (L2) phonological system has been, in general, very scarce. In the present study I examine the acquisition of a nonnative phonological system by adult language learners studying Spanish at Indiana University, Bloomington. The objective of the study was to determine the success of supplementing intermediate Spanish courses with formal instruction in pronunciation. The instruction provided a multimodal methodology aimed to account specifically for individual differences and learning style variation. Variables such as field independence (FI), as measured by the Group Embedded Figures Test (Witkin, Oltman, Raskin, & Karp, 1971), and subject attitude or concern for pronunciation accuracy were examined in relation to improvement in pronunciation. The findings revealed that neither FI, nor subject concern for pronunciation accuracy, were significant predictors of improvement in pronunciation. In contrast, the multimodal methodology resulted in significant improvement of target language pronunciation for the subjects in the experimental group. The article ends with a classroom model of pronunciation instruction designed to enable teachers to incorporate this multimodal method into most second language (L2) curricula. There are also observations about pronunciation errors as they relate to contrastive analysis theory and several suggestions for future research.


William Faulkner is one of the greatest American novelists of the twentieth_century. "A Rose for Emily" is the masterpiece of his short fiction. The paper analyses the causes of Emily's tragedy with particular interest in family background,social factors and the heroine's personality, pointing out the theme is to portray "the conflict between God and Satan" in the human heart.


Introductory Remarks R.M. Zaner. Pertinent Roles and Experiences of All Authors. Ethics Talk Talking Ethics: An Example of Clinical Ethics Consultation M.J. Bliton. Health Care Ethics Consultation: 'Training in Virtue' F. Baylis. Ethics Consultant: Problem Solver or Spiritual Counselor? T. Tomlinson. Anatomy of a Clinical Ethics Consultation B. Hoffmaster. Strange, But Not Stranger: The Peculiar Visage of Philosophy in Clinical Ethics Consultation M.J. Bliton, S.G. Finder. Afterword R.M. Zaner.


The time evolution of a wave packet injected into a semiconductor quantum ring is investigated in order to obtain the transmission and reflection probabilities. Within the effective-mass approximation, the time-dependent Schrödinger equation is solved for a system with nonzero width of the ring and leads and finite potential-barrier heights, where we include smooth lead-ring connections. In the absence of a magnetic field, an analysis of the projection of the wave function over the different subband states shows that when the injected wave packet is within a single subband, the junction can scatter this wave packet into different subbands but remarkably at the second junction the wave packet is scattered back into the subband state of the incoming wave packet. If a magnetic field is applied perpendicularly to the ring plane, transmission and reflection probabilities exhibit Aharonov-Bohm (cid:1) AB (cid:2) oscillations and the outgoing electrons may end up in different subband states from those of the incoming electrons. Localized impurities, placed in the ring arms, influence the AB oscillation period and amplitude. For a single impurity or potential barrier of sufficiently strong strength, the period of the AB oscillations is halved while for two impurities localized in diametrically opposite points of the ring, the original AB period is recovered. A theoretical investigation of the confined states and time evolution of wave packets in T wires is also made, where a comparison between this system and the lead-ring junction is drawn


In the literature on Dutch morphosyntactic microvariation, it is sometimes assumed that a subpart of Dutch dialects lack certain morphemes, because they have no direct phonetic exponent. More careful analyses, however, suggest that these dialects display so-called zero morphemes, whose presence is argued for either on paradigmatic or phonological ground. In this contribution, we present some examples of such morphemes in the verbal inflection and adjectival concord systems, and develop an analysis that, by exploiting the formal mechanism relating underlying and surface phonological representations provided by Turbidity Theory, allows for the formalization of various degrees of emptiness: morphosyntactic, phonological and phonetic. This, in turn, allows for the shifting of the burden of (some instances of) microvariation from morphosyntax to PF.


It is demonstrated that acetylcholine released from cholinergic interneurons modulates the excitability of neostriatal projection neurons. Physostigmine and neostigmine increase input resistance (R N) and enhance evoked discharge of spiny projection neurons in a manner similar to muscarine. Muscarinic R N increase occurs in the whole subthreshold voltage range (Ϫ100 to Ϫ45 mV), remains in the presence of TTX and Cd 2ϩ , and can be blocked by the relatively selective M 1,4 muscarinic receptor antagonist pirenzepine but not by M 2 or M 3 selective antagonists. Cs ϩ occludes muscarinic effects at potentials more negative than Ϫ80 mV. A Na ϩ reduction in the bath occludes muscarinic effects at potentials more positive than Ϫ70 mV. Thus, muscarinic effects involve different ionic conductances: inward rectifying and cationic. The relatively selective M 2 receptor antagonist AF-DX 116 does not block muscarinic effects on the projection neuron but, surprisingly, has the ability to mimic agonistic actions increasing R N and firing. Both effects are blocked by pirenzepine. HPLC measurements of acetylcho-line demonstrate that AF-DX 116 but not pirenzepine greatly increases endogenous acetylcholine release in brain slices. Therefore, the effects of the M 2 antagonist on the projection neurons were attributable to autoreceptor block on cholinergic interneurons. These experiments show distinct opposite functions of muscarinic M 1-and M 2-type receptors in neostriatal output, i.e., the firing of projection neurons. The results suggest that the use of more selective antimuscarinics may be more profitable for the treatment of motor deficits. Neostriatal cholinergic innervation participates in motor control by the basal ganglia receptors of the M 2 type may work as presynaptic autoreceptors that modif y the release of ACh from spontaneously firing cholinergic interneurons (Consolo et al. Despite these physiological actions, the effects of muscarinic receptor antagonists are not as reproducible as those of 3,4-dihydroxy-L-phenylalanine (L-DOPA) at the systemic level. Therefore, they do not constitute the treatment of choice for basal ganglia dysf unctions such as Parkinson's disease (Kopin, 1993; Riederer et al., 1993). Nevertheless, several muscarinic receptors have been cloned (M 1 –M 5), and relatively selective ligands are now accessible (Potter and Purkerson, 1995; C aulfield and Bird-sall, 1998). These ligands have not been thoroughly tested on striatal function or disease models. One reason for this is that antagonist selectivity is still weak (Caulfield and Birdsall, 1998). However, available evidence points toward an important functional segregation between M 1-and M 2-type receptors …


This book provides expert tactics to become and make the most of every swing trade. In Mastering the Trade, veteran trader and educator John Carter shares his hard-won five-point technique for successful swing trading. In addition, Carter helps you move to the next level of confidence by explaining how markets really work and detailing behind-the-scenes market mechanics.


The paper discusses characteristics of radiation, current distribution and excitation of the higher-order modes of the typical self-complementary spiral antennas. The investigated antennas are some of the leaky-wave antennas where the energy leaks during propagation through the spiral arms to produce radiated field. Radiation of the dominant first mode is formed in the specific area described as "the active region". This area depends on the rate of "wrap of the arms". The investigated log-spiral and spiral Archimedean antennas have expansion of the arms exponential and linear, respectively. Expansion of the arms is only the function of angle and therefore these antennas belong to the class of frequency independent antennas.


Indigenous Peoples are the fastest growing and youngest populations in Canada, yet face persistent housing crises across both urban and reserve settings. While Indigenous Peoples often move to cities in search of employment and education, they are overrepresented among the homeless population. This article, summarizing results from the author's doctoral dissertation, provides a review of housing transitions needs and barriers from the experiences and perspectives of 13 Indigenous Elders/traditional knowledge keepers and youth, employing a narrative inquiry methodology and traditional knowledges interpretive framework. The intersection of Indigenous culture, community, housing transition, supports, and barriers is presented, highlighting the narrative voices, experiences, and perspectives of community members and Elders. Implications for service providers, policy, and future directions are included in this work.


Objective To study the relationship between CT value of lung cancer with its differenciation,pathological type and lymph node metastasis.Methods CT value of 378 patients with lung cancers were measured,among which the CT value of different differenciation,different pathological types and different stage of lymph node metastasis were compared.Results The mean CT value of adenocarcinoma was(30.1±8.4)Hu,squamouse cell carcinoma was(39.2±4.2)Hu,small cell of lung cancer was(35.8±3.6)Hu and large cell of lung cancer was(36.4±3.2)Hu.There was obvious difference between CT value of adenocarcinoma and other types of lung cancer.For the same type of lung cancer,the lower of its CT value,the lower of differenciation and the more easely to have lymph node metastasis.Conclusion The CT value is of certain useful in judging the pathological type and lymph node metastasis of lung cancer.


The decision to stay in nursing has been challenged by the recent coronavirus disease 2019 (COVID‐19) pandemic. New nurses joined the workforce and provided care to patients with COVID‐19 although they received limited training, which could have influenced their intention to stay in nursing. We aimed in this study to examine the impact of caring for patients with COVID‐19 on career decisions, resilience, and perceived self‐efficacy among newly hired nurses in Jordan. It also tested the predictors of intentions to stay among new nurses.


The Fermi surface of the noncuprate superconductor Sr 2 RuO 4 has been studied in detail by two-dimensional angle resolved photoelectron spectroscopy (2D-ARPES) using a display-type electron spectrometer and a linearly polarized synchrotron radiation. The existence of the large Fermi surfaces agrees with previous band calculations and conventional ARPES measurements. From the comparison of the observed photoelectron intensity distribution of the Fermi surface with that of the simulation for atomic orbitals, the symmetry of the atomic orbitals composing the Fermi surfaces is revealed to be the d e ; d x y , d y z , d z x -like in contrast to the d x 2 - y 2 -like orbital in the cuprate high- T c super conductor. The possibility of the existence of the extended van-Hove singularity just below the Fermi level, which was suggested by recent conventional ARPES measurements, is also discussed.


We present a new method of measure of the roughness based on the analysis of the texture of speckle pattern on the surface. Images of speckle pattern over the surface are captured by means of a simple configuration using a laser, beam expander, and a camera charge coupled device (CCD). Using the properties of the normalized covariance function that we obtain from the image of the speckle through the inverse Fourier transform, we relate the values of the normalized covariance function. We compare the results obtained with the results obtained with a confocal microscope. This method can be considered as a noncontact surface profiling method and is easy to implement and can be used during the manufacturing process.


Abstract : In this discussion of the causes of the electrical charges in an aerosol are presented and many explanations no longer stand up under criticism today. A report is made on experiments which had as their purpose a survey of the electrical space charge density in different aerosols and the magnitudes of therapeutic aerosols.


We investigate the relationship between fiscal decentralization and income inequality using data from U.S. states over three and a half decades. Our study contributes to the literature in several ways in terms of empirical methodology and specification. First, we take into account integration and cointegration properties of the data and estimate the cointegrating relationship between fiscal decentralization and income inequality using Fully Modified Ordinary Least Squares, following Pedroni (2000). Second, we investigate the direction of the causality. Finally, and perhaps most importantly, we investigate if the relationship between fiscal decentralization and income inequality is conditional on income in each state. We find that fiscal decentralization does reduce income inequality, but only in rich states. We also find that causality runs from fiscal decentralization to income inequality, not the other way around.


The emission of charge carriers from the interface traps as a function of irradiation dose and bias voltage is investigated in terms of Poole–Frenkel effect (PFE) used by deep-level transient spectroscopy (DLTS). The electrical properties in lateral PNP (LPNP) transistors caused by Co60 gamma-ray radiation are measured in situ during irradiation, showing that the interface traps give the main contribution to the excess base current of LPNP transistors. Based on the DLTS results, with increasing irradiation dose, the density of the charged positive interface traps at a given bias voltage increases. This causes an increase in the electric-field strength in the space-charge region and a decrease in the activation energy of interface traps and an increase in the emission rate of charge carriers from the interface traps, showing a similar feature to the classical PFE. However, the charge sign of the interface traps changes from negative to positive, which is different to the classical PFE, and thus displays a new mode of PFE. In order to confirm this conclusion, various bias conditions are employed during DLTS measurements. With decreasing the reverse bias, the electric-field strength increases, leading to an obvious decrease in activation energy of the interface traps and increase in emission rate of charge carriers. Moreover, the interface traps are shown to be uniformly located at the Si/SiO2 interface, and the uniformly distributed interface traps give the new PFE mode, which is independent of the position in depletion layer.


In May 2011, the FDA approved two new protease inhibitors — boceprevir (Victrelis) and telaprevir (Incivek) — for treating patients with chronic


Abstract Henicocephaloides raunoi sp. nov. (Hemiptera: Heteroptera: Reduviidae: Physoderinae) is described based on a single male specimen from Eastern Madagascar, which is deposited in the collection of the Moravian Museum, Brno. The newly described species is illustrated and compared to Henicocephaloides fulvescens Villiers, 1962. A revised generic diagnosis is also provided.


Immediate implant placement into compromised sockets is challenging for clinicians. The 3-dimensional implant position, status of the buccal bone wall, and regeneration of the soft tissue contours all affect adequate esthetic and functional results. This clinical report presents a treatment protocol (a variation of the immediate dentoalveolar restoration concept) consisting of immediate implantation and the reconstruction of the buccal bone wall and gingival recession in a single procedure with a triple graft (cancellous and cortical bone and soft tissue graft). (J Prosthet Dent 2014;112:717-722)


A dynamic of a false vacuum decay is investigated at the end of inflation. It is shown that a creation of a new phase is mainly stimulated by temperature fluctuations. Colliding walls of O(3)-symmetrical bubbles interact weakly with surrounding that leads to large field fluctuations. INTRODUCTION An investigation of a temperature aspect of the Universe evolution and its influence a modern structure and distribution of a matter has a long history. Nevertheless the question on the temperature of the Universe at early stages of evolution is still opened. The evolution of the Universe in this case could be rather different from that with zero temperature [1]. Both cases suppose a presence of scalar field that cause an inflation-a necessary tool of modern scenarios of an evolution of early Universe. There are several ways to choose a Lagrangian of the scalar (inflaton) field. If it possesses more than one minimum the first order phase transitions could take place. This transition proceeds by a nucleation of an O(3)-symmetrical bubbles with true vacuum inside it in the heated Universe and O(4)-symmetrical bubbles in the case of zero temperature. Both sorts of the bubbles can produce particles and large scale fluctuations of the inflaton field during collisions of expanded bubbles. The difference in the original symmetries leads to a meaning difference in a destiny of the large fluctuations. The O(4)-symmetrical bubbles produce a discal matter distribution in an area of their collision. As it was shown in [2] black holes are not produced in this case if one neglects the radiation. The matter distribution after the temperature decay of the false vacuum is rather different as well. As it was shown in [3], there is a real possibility to form black holes during the bubble collision, a number of which is large enough to leave the observable effects. The aim of this paper is to investigate conditions of a dominance of the temperature decay at the end of inflation and the interaction of expanded bubbles with surroundings. DOMINANCE OF TEMPERATURE DECAYS It is well known , see for example [4], that a quantum evaporation of particles in a presence of a horizon could be responsible for the Universe heating 1


The main body of a book is listed in the analytical basis being in progress to the defect that network tradition invasion there exists in check technology,set forth analyse a technology by agreement,and apply the person arriving at invade check systematic design,shorten pattern matching time,The maximum field has been improved invade for detecting efficiency,invading the product inkstone hair checking theory studying and being related to having provided a reference.


The Public Choice criticism of democratic socialism by F. A. Hayek's Road to Serfdom (2007 [1944]) and John Jewkes's The New Ordeal by Planning (1968 [1948]) differs crucially from more recent Public Choice criticism of market socialism by Andrei Shleifer and Robert W. Vishny (1994) and deserves a restatement. Shleifer and Vishny show that market socialism will fail to properly incentive rationally utility-maximizing political actors, and that it will entail unacceptable economic inefficiencies. But Hayek and Jewkes go further and show that democracy as a political system and socialism as an economic system are fundamentally incompatible, making the system of democratic socialism logically incoherent. Democracy cannot fulfill for socialism what democratic socialists expect from it. Democratic socialism will fail, not because those in power will betray their trust or abuse their power, but because the fundamental institutional constraints of democracy are incompatible with socialist economics.


Previous work on 3D freehand photoacoustic imaging has focused on the development of specialized hardware or the use of tracking devices. In this work, we present a novel approach towards 3D volume compounding using an optical pattern attached to the skin. By design, the pattern allows context-aware calculation of the PA image pose in a pattern reference frame, enabling 3D reconstruction while also making the method robust against patient motion. Due to its easy handling optical pattern-enabled context-aware PA imaging could be a promising approach for 3D PA in a clinical environment.


We study numerically and experimentally the dynamics of an incoherently pumped passive optical fibre ring cavity. We show that the cavity exhibits a quasi-soliton turbulence dynamics, whose properties are controlled by the degree of coherence of the injected pump wave: as the coherence of the pump is degraded, the cavity exhibits a transition from the quasi-soliton turbulent regime toward the weakly nonlinear turbulent regime characterized by short-lived rogue wave events. This behavior is reminiscent of the corresponding dynamics obtained in the purely conservative (Hamiltonian) problem. Experimental results are reported by using a standard telecommunication optical fibre system.


Milicia excelsa (Moraceae) is used to treat mental illnesses, among other traditional uses in Africa, but no scientific supports for its use. Hence, this study investigated the antihypoxic potential of the ethanol leaf extract of Milicia excelsa in mice, as well as determined quantitatively the phytoconstituents present in the extract. Hypoxia was induced by sodium nitrite (360 mg/kg, i.p., a haemic hypoxic model) and sodium fluoride (150 mg/kg, i.p., a circulatory hypoxic model) in mice. The phytocompounds were estimated using standard methods. The extract at 500 and 1000 mg/kg, per oral significantly (p<0.05) prolonged the death latency in the haemic hypoxic mouse model while the extract at all the doses (250, 500 and 1000 mg/kg, p.o.) significantly (p<0.05) prolonged the death latency in the circulatory hypoxic mouse model suggesting antihypoxic effect. Total alkaloid was the most abundant of the phytochemicals assayed. This study therefore, concluded that the extract has an antihypoxic effect. The observed antihypoxic effect might be due to the abundance of total alkaloids which may either in synergy or additive with other plant secondary metabolites in the extract be responsible for the observed effect.


FROM time to time in post-mortem reports, a small tumour of the posterior pituitary stalk, called a choristoma, is an incidental finding. Looking through the reports of the Pathology Department of Queen's University, it was possible to find thirty cases of choristoma over the past twenty years. The tumour was first noticed by Boyce and Beadle in 1893, but was called "Choristoma" by Sternberg in 1921. It is also called a granular cell myoblastoma. Histologically, it is a collection of large granular cells, with peripheral nuclei and is now considered by most investigators to be of ectodermal neurogenic origin (Sternberg, 1921; Priesel, 1922; Simonds and Brandes, 1925). A small tumour about 1 mm. in diameter and often multiple, it is generally regarded as being benign, although malignant changes are described (Ross, Millar and Foote, 1952). Pituitary choristomata have no known function. MATERIAL AND METHODS. Tabulating the cause of death in the thirty cases of choristoma


This article provides documentation of the current military presence in U.S. secondary schools and groups that have mobilized to monitor or oppose this presence. This documentation provides the background for a narrative of a multiple-year effort the author engaged in to promote academic freedom for teachers and students and to provide high school students greater balance in the information they receive with regard to opting for military service. This narrative provides insights on the ways advocacy efforts build on previous efforts, the kinds of obstacles advocates encounter when working with school professionals, and strategies for effective activism and policy advocacy with regard to military presence in schools.


This paper is aimed at solving the problems that LBP feature contains outlier and the dimension of LBP fea- ture is too high, and a fast and effective face recognition algorithm based on Robust Local Binary Pattern is proposed. The main idea of RobustLBP is setting a Robust function on the basis of original LBP. First, it calculates the Maha- lanobis distance between the mean vector and every dimension as the argument of Robust function and estimates a set of important information by making Robust function convergence. Then, it obtains a transformation matrix which is used to reject outlier of original feature by using the information. Lastly, it compares the Chi-square distance among the features after reducing dimension in order to complete face recognition. Extensive experiments on FERET, CAS- PEAL-R1 and LFW face databases validate the effectiveness of face recognition.


Conception of the closed and opened systems is cons idered, the method of construction of their mathematical model as make-out point is gr ounded, in particular the linear case is enough grounded from the point of view of the dataware for calculation of make-out point, and developed DSS allows instantly to conduct this computation.


The accuracy of document clustering depends on the user's viewpoints. We make use of queries as the user's viewpoints to enhance cluster-based browsing for a large amount of search results, re ecting the user's interests. Here the queries are incrementally expanded in the process of cluster-based browsing. We present an application of the proposed method to an IR system on the WWW and evaluate its performance by basic experiments.


The title of this research is The Effectiveness Of Using Word Square Learning Method Toward English Learning Out come For 1 st Elementary Students At Narrative Qur'an School Lamongan. This research was designed in quasi experimental with the type of nonequivalent control group design. This design is for experimental group or a control group which is not chosen randomly. The sample of study was 20 students of experimental class and 20 students of control class. Data were collected from pre-Test and post-Test and the questions are 20 multiple choices and 5 essays.The aim of this research is to understand the effectiveness of using word square me thod toward English learning out come for 1 st elementary students at Narrative Qur'an Lamongan.It shows that word square me thod is effective toward English learning out come for 1 st Elementary students at Narrative Qur'an.


The weather environment can severely impact the performance of an overhead distribution system and an electric utility's operational ability. The likelihood of system failure increases due to enhanced line failure rates during bad weather periods. Reliability appraisals without incorporating weather conditions can be quite optimistic and affect planning and design decisions. Recognition of various weather contributions to the total system performance indices help to pinpoint situations where investment may provide maximum reliability improvement. An approach is presented to assess distribution system reliability in different weather conditions such as normal, adverse and extreme and illustrated using a practical distribution system. Reliability indices are evaluated in three different weather states and a series of sensitivity studies are presented. The effects of repair time and the frequency of major storm occurrences are illustrated.


Vibration reduction has been one of the main problems of double-drum vibratory roller which has two drive systems and two vibration systems.Traditional linear theory can not satisfactorily solve the problem of the machine.This paper did the industrial prototype vibration tests to study the dynamic characteristics of isolation system on tandem vibratory roller.In this paper,the tandem vibratory rollers isolation systems research focused on how to reduce the vibration in the rack through experimentation.The experimental results show that: the vibration of the tandem vibratory roller rack is a complex synthesis,which contains two frequency vibrations generated by the interaction,frame shimmy,and the lag damper vibration of the rack itself.In all the vibration components,the majority are two frequency vibrations generated by the interaction and frame shimmy.


PURPOSE
To describe medication adherence and persistence of HIV PrEP overall and compare between sex and age groups of commercially insured individuals in the United States.

METHODS
We conducted a national retrospective cohort study of the Merative MarketScan Claims Database from 2011 - 2019 to describe adherence and persistence of PrEP overall and compared between sex and age groups. High adherence was defined as >80% of proportion of days covered and persistence was measured in days from initiation to the first day of a 60-day treatment gap.

RESULTS
A total of 29,689 new PrEP users identified. Overall adherence was high (81.9%; 95% confidence interval [CI]: 81.5% - 82.3%). Females were more adherent than males (adjusted odds ratio [aOR] 1.87; 95% CI: 1.50-2.34), while those >45-years were less adherent than individuals <45-years (aOR 0.87: 95% CI: 0.81 - 0.93). More than half of individuals discontinued therapy within the first year (median 238.0 days; interquartile range 99.0-507.0 days). Females were less persistent than males (hazard ratio [HR] 1.49; 95% CI: 1.34-1.65), and people >45-years old were more persistent (i.e., lower risk of discontinuation) than those <45-years (HR 0.43; 95% CI: 0.33-0.55).

CONCLUSIONS
These findings show adherence to daily PrEP is high among commercially insured individuals but the majority still discontinue in the first year. Future research should investigate what factors influence PrEP discontinuation among this population and ways to reduce barriers to therapy maintenance to ensure the population-level benefits of PrEP treatment. This article is protected by copyright. All rights reserved.


Objective To investigate the effects of the left ventricular structure in the patients with hypertension and early glycol-metabolism disorder.Methods A total of 90 hypertension patients in stage II and 30 controls were observed,the hypertension subjects were divided into two groups according to 2hPG:essential hypertension(n =51 ) and hypertension with hyperglycemia(n =39).2h postprandial blood glucose(2h PC),blood pressure(BP ),inter-ventricular septum thickness (IVST),left ventricular posterior wall thickness(LVPWT),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)were measured.Left ventricular mass(LVM) and relative wall thickness(RWT) were calculated based on these parameters.2hPG and left ventricular structure were compared in each group.Results In 90 cases of grade two hypertension,the incidence of glucose metabolism abnormality was 43.33%(n =39).Compared with other two groups,2hPG and body mass index(BMI) in hypertension with hyperglycemia group were significantly higher,and the result had statistical difference(P 0.01).IVST,LVPWT,LVM and left ventricular mass index(LVMI) in essential hypertension group and hypertension with hyperglycemia group were obviously higher than that in the controls(P 0.01 ).IVST,LVPWT, LVM and LVMI in hypertension with hyperglycemia group were higher than that in the essential hypertension group(P 0.05),but there had no statistical differences.Conclusion Hypertension always complicated with glucose metabolism abnormality. Hypertension with hyperglycemia might accelerate and aggravate left ventricular remodeling.Early period of abnormal glycol-metabolism might be an important risk factor which affected left ventricular structure in hypertension cases.


This paper surveys the significant progress over the past couple of decades in the theory of stratified spaces through the application of controlled methods as well as through the application of intersection homology.


The field of Artificial Intelligence (AI) is enjoying unprecedented success and is dramatically transforming the landscape of the financial services industry. However, there is a strong need to develop an accountability and explainability framework for AI in financial services, based on a risk-based assessment of appropriate explainability levels and techniques by use case and domain.This paper proposes a risk management framework for the implementation of AI in banking with consideration of explainability and outlines the implementation requirements to enable AI to achieve positive outcomes for financial institutions and the customers, markets and societies they serve. The work presents the evaluation of three algorithmic approaches (Neural Networks, Logistic Regression and Type 2 Fuzzy Logic with evolutionary optimisation) for nine banking use cases. We review the emerging regulatory and industry guidance on ethical and safe adoption of AI from key markets worldwide and compare leading AI explainability techniques.We will show that the Type-2 Fuzzy Logic models deliver very good performance which is comparable to or lagging marginally behind the Neural Network models in terms of accuracy, but outperform all models for explainability, thus they are recommended as a suitable machine learning approach for use cases in financial services from an explainability perspective. This research is important for several reasons: (i) there is limited knowledge and understanding of the potential for Type-2 Fuzzy Logic as a highly adaptable, high performing, explainable AI technique; (ii) there is limited cross discipline understanding between financial services and AI expertise and this work aims to bridge that gap; (iii) regulatory thinking is evolving with limited guidance worldwide and this work aims to support that thinking; (iv) it is important that banks retain customer trust and maintain market stability as adoption of AI increases.


In this study, we aim at investigating the role played by the metal surface as a possible dissipative channel in the photoisomerization process of azobenzene-derivative-based self-assembled monolayers (azo-SAMs). In particular we compare the cases of gold and platinum. We study the excitonic transfer phenomena of two azo-derivatives (both in trans and in cis conformation) chemisorbed on Au{111} and Pt{111} to the metal surfaces. The metal effects are evaluated within the local and nonlocal regimes, showing that nonlocality in the metal response plays an important role and nonlocal accounting quenching rates are one order of magnitude smaller than the corresponding local results. The couplings are stronger for Au{111} than for Pt{111}, but for both cases the energy transfer between the molecule and the metal turns out not to be able to suppress photoisomerization.


Introduction : Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with a very indolent clinical course and patients may survive for many decades. First-line treatment with purine analogues such as cladribine (Cld) is considered standard of care since it is very efficient and induces profound remissions. However, patients with HCL often relapse after purine analogues and repeated treatment may increase morbidity and mortality. Despite good clinical evidence of long term control of the disease by several mainly single center studies of patients treated with purine analogues, there is only one study analyzing mainly subcutaneous (sc) treated patients based on registry data. We therefore performed a pooled long-term follow-up analysis of our prospective multicenter studies treating patients with sc Cld focusing on survival, secondary malignancy and retreatment.
 Materials and Methods : The SAKK included patients treated for HCL in 4 studies between 1993 and 2005. Three studies focused on first-line regimens with sc Cld, whereas the fourth protocol focused on the effect of Rituximab monotherapy in patients pretreated with Cld. Classical morphologic, immunohistochemistry and flow cytometry criteria were used as inclusion criteria and response was assessed by established criteria. Treatment algorithms in the 4 studies were as follows: 1) 5 days of Cld 0.14mg/kg sc followed by max 2 cycles of 7 days of Cld 0.1mg/kg sc in case of minor response or no response (SAKK 32/93); 2) Single shot of Cld 0.25mg/kg sc followed by a maximum of 2 cycles of 0.14mg/kg sc for 5 day in case of minor response, no response or relapse (SAKK 32/95); 3) 5 consecutive days of Cld 0.14mg/kg sc versus the same dose in 5 weekly applications (SAKK 32/98); 4) Rituximab 375 mg/m2iv weekly for 4 weeks in relapsed patients (SAKK 31/98). SAKK 32/93 included 63, SAKK 32/95 74 and SAKK 32/98 100 patients. Of the 26 patients registered in 31/98 20 were already in SAKK 32/93, 32/95 and 32/98. Therefore, we also included the treatment information and follow-up data of these 20 patients. All patients were subject to life-long follow-up within the clinical trials. Further information including secondary malignancies and retreatments were obtained by sending out questionnaires to the treating physicians of the study patients. Of the 237 patients 4 patients were in two of the studies and 10 patients have been excluded because of non-classical HCL phenotype. Therefore, a total of 223 patients were included in the analysis. Overall survival and follow-up time were assessed by Kaplan-Meier and reverse Kaplan-Meier method, respectively.
 Results : The median age of patients at the time of diagnosis was 55 (range 21 to 96) years, 50 patients were female (22.4%) and 173 (77.6%) male. At the time of data analysis, the median follow-up time was 12.1 (95%-CI 10.0 to 14.0) years. A total of 129 (57.8%) patients had the last follow-up information more than two years prior to the data cut-off in May 2016, however, the available information of all patients was used for the sub-analyses including secondary malignancies or retreatment. By the cut-off date, 49 patients have died, 14 (28.6%) due to secondary malignancies and 7 (14.3%) due to HCL progression. Median overall survival from diagnosis was 31.6 (95%-CI 31.6 to 37.8) years. Retreatment was necessary in 53 (23.7%) patients after a mean of 6 (0.2 to 20.4) years and first retreatment was mainly Cld (64%), rituximab (19%) or Cld and rituximab (13%). 21 patients (9.4%) required more than one retreatment with a mean number of 1.57 (range 1 to 5) treatments. A total of 42 (18.8%) patients developed secondary malignancies with an average time to occurrence of 7.1 (range: 0.1 to 17.7) years. The majority of the secondary malignancies were of non-hematological origin (85.9%), most frequently skin cancer (31.0%), followed by prostate cancer (19.0%) and colorectal cancer (16.7%). Six patients (14.4%) developed hematological secondary malignancies with a predominance of B-lymphoid neoplasms.
 Conclusion : Long-term overall survival in HCL patients treated with sc Cld was excellent and comparable to studies using iv Cld. Despite the long follow-up, sc Cld had a curative potential and relapses requiring re-treatment were observed only in a minority of patients. Secondary malignancies were predominantly non-hematological. These data indicate that patients need to be followed carefully with a special focus on secondary malignancies.

 Chalandon: Roche: Membership on an entity's Board of Directors or advisory committees, Other: Travel costs.


ions are 0, 0, 0, 4, and 1 respectively. We are grateful to an anonymous reviewer for the suggestion of collapsing the two categories for purposes of statistical analysis. 8 For all the 75 instances of nouns denoting the meaning of 'abstractions' in the string of a bunch of NOUN, 44 instances are colored with negative evaluation while 30 with neutral meaning and only one instance of positive meaning. 9 We are grateful to an anonymous reviewer for drawing our attention to the use


This paper studied the outbreak physics of green tide algae based on its mechanism. This paper divided the green tide outbreak into four stages, i.e., the incipient stage, outbreak stage, maintenance stage and extinction stage, and combined the growth curves of the different growth stages of Enteromorpha based on the two main factors of temperature and illumination, according to the green tide biomass prediction equation, to achieve a comprehensive forecast of the final green tide biomass and to provide data support for green tide control and salvage.


A study was conducted in uniformly packed horizontal soil columns initially wetted to 0.075,0.184 and 0.280 cm3 cm−3 water contents. The columns were subjected to 0.5 and l°C cm−1 temperature gradients by maintaining differential temperature at the ends through the heat source and the sink. At all the water contents and boundary temperatures, the soil columns attained a steady temperature and water distribution within 3–4 hours and 150 hours, respectively. At 0.184 cm3 cm−3 initial water content, the reduction of, water in the first half (hot side) of the column and consequent increase in the second half (cool side) was greater than that in the columns with initial water contents of 0.075 and 0.280 cm3 cm−3. When the temperature gradient was increased from 0.5 to 1°C cm−1 the reduction of water in the first half and consequent increase in the second half of the column increased at all initial water contents. The net water flux was maximum in 0–36 hours interval, less in 36–76 hours interval and least in 76–150 hours interval at all the initial moisture and temperature gradients. Also, the flux was always maximum at 0.184 cm3 cm−3.


Transient absorption spectra for aluminium sulphonated phthalocyanine dyed into water-saturated cotton fabric and for powdered samples of titanium dioxide and cadmium sulphide have been obtained by the technique of diffuse reflectance laser flash photolysis.


The Pavilion is an alternative secondary school for disengaged young people within the Northern Metropolitan Region. The Pavilion has two mission statements drawn from the Universal Declaration of Human Rights. - Everyone has the right to education. - Education shall be directed to the full development of the human personality and to the strengthening of human rights and fundamental freedoms.


This study examined the effectiveness of using website in learning Arabic language for the purpose of tourism at the Department of General Studies at the College of Poly-Tech MARA, Kelantan Darul Naim. Descriptive study is used to describe briefly about the Arabic Language for Specific Purposes and analyze the effectiveness of website as a main tool in learning activities. This paper is done based on questionnaires and observation in class HFA-1023 (Bahasa Arab Asas Untuk Pelancongan dan Hospitaliti). A questionnaire was distributed to 43 students that have been registered for this course. The descriptive quantitative analysis was used to analyze the data by using SPSS. In general, the finding provides evidence that using website in learning the Arabic language for the purpose of tourism was efficient, and the researcher found that new technologies represent a valuable and effective support for students in learning language for specific purposes.


"Fat Lives: A Feminist Psychological Exploration." Irmgard Tischner. Routledge. October 2012. --- Within the context of the current 'obesity debate', this book investigates the embodied experience of 'being large' from a critical psychological perspective. Using poststructuralist and feminist theories, the author explores the discourses available to and used by self-designated 'fat' individuals, as well as the societal power relationships that are produced by these. Megan O'Branski finds this book is a concise, readable exploration of the intersections of multiple embodied subjectivities competing for the construction of the "ideal" feminine.


Scrum describes a separation of roles; the product owner is accountable for achieving business objectives and the team for technical execution. A pragmatic and collegial relationship between a product owner and team can satisfy the definition of collaboration and honor roles while barely tapping or actually working against the potential of a project and its participants. This paper surveys literature to describe different forms of collaboration, to establish that deep, unbounded collaboration is at the heart of agile values, and that partnerships of high trust and shared risk lead to value and innovation. Finally, this paper incorporates a real- world example of a product owner who, while remaining accountable to the outcome, shared ownership over vision, priorities and execution with her scrum/XP development team.


To determine the possibility of using a mineral pigment based on the rutile form of titanium dioxide in the production of volume-colored ceramic brick in order to obtain lighter brick tones the studies are conducted. The previously studied low-melting clay of the Tyumen deposit was used as a basis. It was established that significant lightening of the brick does not occur even with the introduction of 8% of the specified pigment, although some lightening is appeared. In addition, with the pigment introduction, an increase in water absorption of bricks is observed, which leads to a decrease in the sample strength. Increasing the firing temperature to 950°C does not lead to an improvement in the quality characteristics of the samples, and even vice versa makes them worse. Thus, the use of a white pigment under investigation does not give a significant effect of lightening of ceramic red-burning clay.


The essay is to discuss the background of the purchase and bid of literature resources in university libraries,analyze the feasibility and superiority of implementing way of purchase bid.It also makes a study on the current situation and existing problem of purchase bid and its policies and countermeasures.


This paper presents the foundations of a method, that allows the modelling, design and control of complex systems, based on the agent paradigm. It allows to integrate in a single model, knowledge obtained from the different levels of observation of the system. An agentification strategy of the concept of organization is proposed. This method deals with a pratical issue: the difficulty to specify a system at a single level of observation. Applications related to biology and biological manufacturing systems are presented.


end. The art that the invention defined in the claims. The invention written after supplying paper, when it is always on the recording paper automatic feeding mechanism of the ink-jet printer capable of forming images of high resolution hameuroseo remove the paper support and the pick-up roller the printer is printing. I. Technical Solution invention to solve. The present invention is to provide a recording paper automatic feeding mechanism of the ink-jet printer which can improve the print quality and stabilize the conveying force of the recording paper. All. Solution subject matter of the invention. The present invention is an ink jet according to the recording paper automatic feeding mechanism of the printer, the reciprocating of the solenoid by rotating around the solenoid, and a projection when the hinge of the solenoid which end is projecting or insertion according to the supply if the drive voltage according to the signal of the control movement convert a rotational movement will be characterized in that it comprises a cam for pressing the other end of the front surface of the paper support. la. An important use of the invention. Inkjet printers.


A novel analytic solution to field distribution is used to calculate the intensity distribution for channel waveguides with a two-dimensional diffusion-type refractive index profile. Composition profiles for the waveguides are obtained by applying the two-dimensional diffusion theory to treat the case of isotropic sideways diffusion. The dependence of the field distributions on the width/depth ratio is studied as an aid to the design of modulators and switches for integrated optics.


We study the higher-order heat-type equation with first time and Mth spatial partial derivatives, M = 2, 3, …. We demonstrate that its exact solutions for M even can be constructed with the help of signed Lévy stable functions. For M odd the same role is played by a special generalization of the Airy Ai function that we introduce and study. This permits one to generate the exact and explicit heat kernels pertaining to these equations. We examine analytically and graphically the spatial and temporary evolution of particular solutions for simple initial conditions.


Today, blockchain uses a list of various blocks for storing a distributed flat of invariable information that informs of a set of replicated logical things in the Internet of Things (IoT). In the blockchain, a set of blocks includes various transactions containing a cryptographic hash value and a timestamp. Blockchain‐as‐a‐service (BaaS) as a new service in cloud providers presents an infrastructure for accessing users to execute, manage, and monitor blockchain applications without high secured infrastructure requirements. Recently, BaaS concepts widely have used the management of IoT applications in different layers such as network, data, control, and resource. This paper provides a systematic review of recent research studies in BaaS models. The main goal behind this review is to categorize the applied scenarios, trends, evaluated Quality of Service (QoS) factors, new challenges, and open directions on BaaS models in IoT management. To evaluate the existing research studies in this field, five analytical research questions are proposed to analyze the technical aspects of each study. The analytical results based on existing research questions specify that the BaaS models are applied to network layer to manage IoT environment more than other layers. Also, security and privacy are two important factors to evaluate the existing BaaS models in cloud‐edge IoT environments. Finally, the integration of BaaS models on IoT environments with interconnections of cloud‐edge computing and software defined networks creates great secure opportunities for smart environment applications to monitor, manage, and improve all the atomic services and resources.


ABSTRACT Iron deficiency is a serious nutritional disorder in aerobic rice, causing chlorosis, poor yields and reduced grain nutritional quality. The problem can be managed by complementing the use of Fe-efficient plant type with a suitable Fe management strategy. In the present paper, we report the effect of eight iron management practices to resolve the problem of iron (Fe) chlorosis through the use of an iron deficiency tolerant (IDTR) and iron deficiency susceptible (IDSR) rice genotype, i.e. Pusa 33 and ADT 39, respectively. Fe deficiency tolerance of these genotypes was related to the root release of PS which enabled a higher uptake of Fe in the IDTR than the IDSR under Fe deficiency. In general, IDTR performed better than the IDSR as evident from a significant increase in total iron, active iron, chlorophyll content and grain and straw yield. IDSR produced the highest grain and straw yield under slow iron release nano clay complex source. Grain Fe content of the IDTR and IDSR increased by 18.9 and 13.4%, respectively, under recommended dose of Fe. The results identified the most effective soil management strategies for the alleviating Fe deficiency chlorosis and improving Fe nutrition of both IDTR and IDSR genotypes.


Give the pupils something to do, not something to learn; and the doing is of such nature as to demand thinking; learning naturally results. John Dewey Teachers, as facilitators of learning, are constantly soul searching, looking for sound transaction styles that are known to raise teacher efficiency. Making classrooms spaces that are joyful, learner-centric and engaging requires enormous portions of ingenuity on the part of a teacher. 'Learning-by-Doing' is a psychologically robust way of learning. It not only etches lasting memory but also makes the process of learning a meaningful experience. Self-learning within groups instils lessons on collaborative and social discipline and thus prepares the learner to face adversity in preparation for life. An effective curriculum should provide for multiple intelligences to fruition, thus raising correlation between subjects, providing scope for every student to engage in the act of discovery. Unplugged education, outdoors education, learning through engagement are all hands-on strategies that are novel and significant in holding attention levels in an era that is overwhelmed by technology and digitisation. The 'STEAM Curriculum' holds great relevance in contemporary education and it stems from learning engagements advocated by this model, permitting multidisciplinary correlation and reflection on action. This paper provides the framework of a lesson that is transacted hands-on through inquiry and reflection. It provides a prospective teacher of this model with the syntax and the pathway of deliberation. This is a general prototype that bears a multidisciplinary essence and thus can be extrapolated in varied situations, levels and academic disciplines of learning.


Abstract. This study examines the response of Square Dome-shaped Kirigami (SDK) structures when used as a core in cladding systems under blast loading conditions. A numerical model of the SDK foldcore is developed on the commercially available software ABAQUS. The SDK foldcore made of an aluminium sheet is placed between two rigid plates. The model is put under a quasi-static compression test to simulate the crushing effect and the results are used to calibrate the simulation with the experimental data from the literature. To evaluate the blast resistance of the system, four different levels of blast loading conditions are applied to the top of the top plate using Trinitrotoluene (TNT) explosive, with a distance of 1500 mm from the centre of the top plate. The structural response of the SDK foldcore is then compared with that of a traditional Square Honey Comb (SHC) core under the same blast loading conditions. This study aims to evaluate the relative performance of the two different cores in terms of their ability to mitigate the effects of blast loading. The SDK foldcore demonstrated the capability to disperse blast energy over a wider area, thus decreasing the stress the cladding system experienced. The results of the study show that SDK foldcore provides a significant improvement in energy absorption, with a maximum reduction of 70% in the peak load transmitted compared to the case with no cladding. The peak load transmitted by the SDK foldcore is much more consistent than the SHC core, even under different blast loading conditions. This is due to its favourable plastic deformation, which prevents complete densification. These results suggest that the SDK folded structure has better performance in mitigating the effects of blast loading.


Summary Analyses of the urinary steroids of male neurotic- and manic-depressive patients revealed significant elevations of the 17-KGS, but not of the 17-KS or 17-OHCS. A statistically significant rank correlation was found to exist between the patients' clinical states and the amounts of 17-KGS they excreted. We are indebted to Prof. H. A. Harper, and CDR R. H. Watten, for advice in the design of this study; to Dr. Gerold Grodsky, for assistance in establishing the biochemical procedures and to Dr. E. L. Alpen, for aid in statistical evaluation.


It is of great significance to grasp and control the relationship between organizations and employees for the healthy development of an organization. This paper measured the closeness and distance of the employee–organization relationship. The results were based on an investigation of 554 employees. (1) The mean value of the employee–organization psychological distance (EOPD) was 3.51, indicating that the relationship between the employee and organization was not optimistic. (2) 48.79% of the 554 interviewees maintained "existence" relationships with their organizations, 28.13% of people maintained "exclude" relationships with their organizations, 20.44% had a "loyalty" relationship, while only 2.64% had an "integrated" relationship with their organization. (3) EOPD showed significant differences in terms of age, marital status, education, career, position and area of residence. (4) Detailed analysis was undertaken to explore the distribution characteristics of four relationships, and specific rules were found. Our research provided a new perspective and related references for the further study of organizational management.


Effectiveness of the fast swinging micro tip strake technique for controlling forebody vortex asymmetry at high angles of attack has been investigated and de veloped in low speed wind tunnel experiments on a slender body of revolution wi th pointed nose configuration. At high angles of attack ( α 25°),the new m ethod was effective in suppressing side force to zero level with only very smal l energy input, demonstrating the leveraging available through controlling the v ortex flow field at the point of instability. The cross plane flow field on the lee ward of the forebody were measured by seven hole probe, and the vorticity m ap and the total pressure coefficient contour map revealed the symmetric vortex state under the unsteady micro perturbation control.