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I don't think any organisation was putting all their eggs in Shohei Ohtani's basket, but it is understood that all 30 MLB organisations had answered the questionnaire circulated asking them why they would be the best fit for the Japanese two-way sensation, thus suggesting they all at least had an interest of at least $20 million to pay the posting fee to the Nippon Ham Fighters.
Ohtani was officially posted on the first of the month (December), starting the clock for him to sign a deal to join the Majors – a minor league deal at that. With all teams submitting their completed questionnaires, they had in essence all bought a ticket for the raffle; less than 48 hours later, half of the MLB teams have seen their dreams shattered (whether realistic or not) as Ohtani's representatives, CAA, began telling clubs he would not be joining their ball club. The clubs yet to announce if they are still in the running, or are being reported as 'having a chance', will be given a chance to meet directly with Ohtani to persuade him to join; the rumour-mill seems to be suggesting there is a 'West-coast' feel surrounding Ohtani's outlook.
There will no doubt be more teams to drop out of the sweepstakes, but at least the teams already told 'thanks, but no thanks' can begin planning for 2018 without finding a way to squeeze in the superstar. We look at potential reasons why some clubs were given the cold shoulder, and where they'll turn next.
New York Yankees
No doubt the biggest shock to come out of the early Ohtani news was that the Yankees were not even going to get a seat at the table with the superstar to try and persuade him to play in the Bronx. One of the early favourites, East Atlantic Look even tipped him to land there, Brian Cashman came out to publicly say that though their presentation was well received with 'outstanding feedback', they wouldn't be moving further. Whilst the Pinstripes no doubt had a great season in 2017, and will be projected to emulate that if not improve upon that in 2018, it's hard not to feel that their lack of urgency appointing a manager may have hampered their chances when it comes to attracting the Japanese superstar – it's hard to say 'yes' to somewhere when you don't know who you'll be playing for? Couple that with Ohtani's 'West-coast dream' and even thought the Yankees traded for more money in their international spending pool, ultimately their postcode didn't fit.
Without Ohtani to add to the rotation, and contact having been made with New York legend CC Sabathia about returning, there is a feeling that the Yanks may be shaping up to head into 2018 with a familiar feel to last time around. With Masahiro Tanaka committing (unexpectedly after his '17 post-season), and CC possibly returning, the Yankees rotation could well be identical to how it finished. Finding a Designated Hitter should be top of the new boss' 'to-do list'; Jacob Ellsbury is being projected as their starter at present. Ellsbury won't excite many having declined significantly (most notably in durability) in recent years, and it may be best for the Yankees to cash in for some prospects whilst they can, meaning they need a DH. With limited explicit DH's on the Free Agent market, picking up a bat like J.D. Martinez or Carlos Santana and splitting their time between DH and the OF/1B respectively wouldn't be the worst move. Left field call? Sign Jonathan Lucroy (a year removed from batting .292) as a back-up catcher who can share time behind the plate and as a DH with Gary Sanchez – we're still less than convinced by his work behind the plate but his power cannot be knocked, DH would suit him perfectly but at 25 will he want pigeon-holed? We're not convinced that Austin Romine is the best back-up – an average bat and poor arm – trading him away and freeing up a back-up place would be fairly forward thinking – Lucroy would be guaranteed near 500 PAs if fit and Sanchez would be able to play every game. Hey, maybe train him into a 1B over the next couple of Spring Training sessions and then get a full-time catcher for 2020?
Boston Red Sox
Dave Dombrowski announced early that the Red Sox had 'not been invited to make an in-person presentation' – sucks, right? At least they weren't the only 'big dog' to fall at the first hurdle. Boston may feel as though their small (in comparison) international signing pool was a factor, though some teams still in the mix have comparable amounts and less so the geographical excuse is likely more suitable. The Rox thought they were in-play on Ohtani having housed some Japanese stars in the past, and no doubt would have mentioned their need for a DH bat as well as a back of the rotation guy. Maybe Ohtani knows imself that his arm is what will earn him the big money and that top of the rotation is more important to him than originally thought.
The Rox still need a big bat, and having now missed out on Ohtani and likely out the race for Stanton, attention will turn to the Free Agent market and trades. Still a big player on Martinez, there is talk that the Red Sox could make a play for Eric Hosmer, though there is one 'big bat' there and one on-base guy – Boston need the former. It's getting to the stage that Boston may be beginning to regret not listening to David Ortiz and taking a bolder line on Edwin Encarnacion in last year's FA market, especially considering the contract he ultimately signed. They likely have to give up too much for him in a trade to make it worthwhile now, but unable to afford to wait it out until the 2018 FA class for a bat, the Rox will need to act fast to have a chance in 2017 – is there pursuit of Jose Abreu the answer? I'd give up the pick and get some pop back to Fenway Park; sign Martinez to a multi-year, line Scott Boras' pockets and contend properly in 2018.
Minnesota Twins
The Twins were getting a lot of airtime as sleepers on Ohtani; a smaller franchise on the back of a postseason with some good assets but where he would still be undoubtedly the 'big fish'. It's hard to know explicitly why certain teams were shooed out, but maybe Ohtani feels the Twins will be nearer their 100-loss season of 2016 than the 2017 Wild-Card heroes. This will be the first off-season that the new Twins Front Office have to build their 'own' team – there have already been some backroom staff changes, but don't expect anything too major to happen on the front benches, especially after Paul Molitor was named American League Manager of the Year for 2017.
Expect the Twins to dip into the FA market for a starting pitcher and a big bat – keeping as much of the 2017 core together as possible will be key, but additions for those lost too free agency/non-tendered is always important. Likely to be priced out of many of the big names, the Twins could do worse than offering multi-year deals to Michael Pinada who will be back after Tommy-John surgery, likely lowering his expectancy of potential earnings. As for a bat, a lot depends on their arbitration feelings towards Eduardo Escobar and Ehire Adrianza – a utility infielder could be needed as cover or alongside Brian Dozier – Ryan Goins on a very cheap deal now Toronto Blue Jays have non-tendered him? Otherwise it could be a case of risk-taking for the Twins – Alex Avila depending on price could be a bounce-back candidate.
Washington Nationals
Did they need him? Were they just in it on the off chance? With two of the best pitchers in baseball leading the rotation, and not bad depth behind him, the Nationals probably didn't need to go in too hard on Ohtani. Couple that with a lack of DH to offer at-bats, and a pretty stacked outfield with MVP calibre players, the Nationals are likely one of a few clubs that are not too sorry to miss out on him. Had they landed him, it may have been a case of seeing how he does and how good he really is before the 2018 free agency and Bryce Harper hitting the market – I'd be amazed if 'the opportunity to play alongside Harper and behind the best starters in the Majors' wasn't in the original submission, but it may have just been filling lines. Anyway, the Nationals have the capital to just pay big on Ohtani in a couple of years if they want him and he is proven by that stage, around the time they'll need new starters…
Oakland A's
I only put them here as the A's are seemingly the only west-coast side to be ruled out explicitly at the early stage. Not sure they were ever a realistic candidate, but there were hypothetical (more 'imagine if…') scenarios bounced around saying that Ohtani may have an obscure affiliation to somewhere rouge due to a random link – I'm not sure how big Moneyball is in Japan.
These aren't the only teams to miss out on the face-to-face meet – the so called 'Round 2' – and in the end 29 teams will fall short, of those still left in the hat, west-coast clubs are being tipped, leading many to think that LA Dodgers or San Francisco Giants are the favourites – can San Fran really land both 'big names' of the off-season in Ohtani and Giancarlo Stanton? San Diego Padres are the big sleepers on this – there's a long way to go in this one, but it's certainly got everyone fixated. Baseball's answer to X Factor, something whoever lands him certainly hopes Ohtani has.
Hold tight, James Dawne.


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Back to Syllabi Back to Review 2016 "Home"
Seminar In Studio Design: Syllabus
MCO:5455 – CRN:45278, Purchase College Fall '16
Room #MUS-1045 Mondays 4:30-6:20
Instructor: Peter Denenberg
email@example.com / 914.251.7933
Course Description
Seminar in Studio Design explores the nitty gritty involved in setting up a modern project / recording studio. In-class demonstration / discussion on analog signal routing and systems design, how to read block diagrams. Basic room acoustics & design are covered, how to "float a room", a/c systems, diffusion, near and far field monitoring, construction resources are discussed. How to function in a "less than perfect" control room, moving things around to work better in any given space, guerilla acoustic treatments, choosing an equipment list to design project studios based on project specific goals and user budgets explored.
Recommended Reading:
The Studio Builder's Handbook: How to Improve the Sound of Your Studio on Any Budget
by Bobby Owsinski (Author), Dennis Moody (Author)
This subject requires all students to have access to a digital audio workstation (DAW). The recommended DAW is ProTools 12. The following DAWs may also be used, though only limited support and instruction will be provided: Logic (Pro or Express), Cubase, Reaper, Digital Performer, Sonar, or FL Studio, Ableton Live. The Purchase library has ProTools installed on several computers and these can be used for classwork.
As a result of meeting this course's requirements students will be able to; Budget for and assemble an intelligent project studio. Be better equipped to run a multi-microphone ensemble session and successfully manage and record their own sessions.
Attendance Policy
Students are expected to meet all attendance and participation requirements in music classes. Unexcused absences, tardiness, or lack of preparation for class will not be accepted; students are allowed two excused absences (with prior permission only), three unexcused absences in any course earn a student a failing grade for that course. Two late arrivals equal one absence.
Course Grading
Grades based on attendance 50%, class participation and homework 50%
In order to receive an A on an individual writing assignment, students must submit complete, thoughtful answers that are grammatically correct, and that demonstrate good academic writing style. They must be turned in on the stated due date to receive full credit — no exceptions.
Academic Honesty
In this and all of my classes, every student must be aware of and adhere to the college's policy on academic honesty. See the Student Handbook and other college publications for the policy http://www.purchase.edu/coursecatalog/2008-10/AcademicPolicies/General/Integrity.aspx
Academic Progress within the Major- Conservatory of Music Policy
A grade of "C" or better must be obtained for all core music classes within a major. Core classes are any music courses that appear on the 8 Semester Plan for graduation. A C- or below constitutes failure to progress academically and is grounds for dismissal from the major. Once the Conservatory is notified as to a student's standing he or she will meet with the BOS area head. A letter will follow from the Director's office informing the student that due to "poor academic progress" he or she will be counseled into another in the program of study.
Professional Standards – School of the Arts
Breaches of professional conduct are grounds for dismissal or probation depending on the severity of the infringement. Examples of poor professional conduct include, but are not limited to, poor treatment of facilities and studios, lack of preparation for rehearsals and/or lessons, disrespectful/disruptive behavior directed toward peers, faculty, administration and staff. The Conservatory of Music follows the SOA procedures for due process for any possible infractions.

subset: commoncrawl


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text: The Knudsen Vineyards 2013 Pinot Noir is a beautiful, light-red ruby color, is medium bodied and exhibits energetic red fruit aromas with a subtle hint of wet stone. It's wonderfully balanced acidity and robust mid-palate mouth feel lead toward an unusualy long finish. It superbly showcases the nuance, depth and complexity of the fruit from Knudsen Vineyards.


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Blue Ridge Community and Technical College 400 West Stephen Street Martinsburg, WV 25401 Phone: (304) 260-4380
General Information About Blue Ridge Community and Technical College
Blue Ridge Community and Technical College is dedicated to providing a diverse student population with collaborative programs and support services to improve the quality of life and promote economic development in its service area. Its quality academic programs are learner centered and focus on career entry, university transfer, developmental education, and workforce development.
Institutional statistical data was gathered from the U.S. Department of Education - Institute of Education Sciences, National Center for Education Statistics, 2009-2010.
Institution Type
- 2-year, Public
Special Learning Opportunities
- Distance learning opportunities
- Weekend/evening college
Student Services
- General Education Courses
- Career Services available upon completion
Credit Accepted
- Dual credit
- Credit for life experiences
- Advanced placement (AP) credits
- The acceptance of credits for work experience or military experience are subject to review by the school and cannot be guaranteed.
Religious Affiliation
- Not applicable
Federal Aid
- Eligible students may receive Pell Grants and other federal aid (e.g. Direct Loans).
Degrees/Certificates offered
- 1-2 years certificate
- Associate's degree
Campus Setting
- City: Small
Disability Services Student
- 3% or Less
Admission Total Applicants Full Time Retention Rate 55%
Student Demographics Total Enrolled 3,677 Native American 19.0 Asian 57.0 African American 337.0 Hispanic 133.0 Enrolled FullTime Undergraduates 1,049 Enrolled FullTime Graduates


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November 25, 2015
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Grace Constable
"Pass the mashed potatoes please," I shout from across the long, mahogany table set for twenty, yet meant for twelve. Half of us are seated on Aunt Kath's nice cushioned, wooden chairs, and the other half sit on the old, white folding chairs that Uncle Jeff found in the basement. Aunt Denine passes the potatoes to Pop Pop, who passes them to Uncle Jeff, and from there they're passed down the table by a few more cousins before making their way to me. I scoop three big spoonfuls onto Aunt Kath's good white china, for they are the only Thanksgiving food I particularly like. But I am not the only one with peculiar eating habits. I look around and notice the food patterns throughout the table. Cranberries and spinach only inhabit the plates belonging to the adults, while the children's plates lack vegetables of any kind. My brother Gedd's plate is piled high with turkey, and turkey only. Pop Pop's plate is full of virtually every food that has been cooked for the occasion, while Uncle Jeff's is already scraped clean.
Conversation is its own tradition at our Thanksgiving table. Every year I can count on my cousin Lily telling a funny story about my Aunt Kiki, Pop Pop not being able to hear anything that is going on and shouting nonsense, my cousin Austin enlightening us on the sports highlights of the week, and Uncle Rick playing us his new favorite song on Uncle Jeff's guitar. Dinner is full of laughter; it's the night of the year that I feel the happiest.
I notice other patterns throughout this complicated web of such different individuals I call my family. There is a distinct line down the center of the table that separates the old and the new. On the left, the older generation discusses stories and events that us teenagers are too young to remember. And on the right, half the teens discuss recent gossip at our various schools, while the other half opts out on conversation altogether in favor of their cell phones.
All around me are the faces of the people I feel closest to. It seems silly to think that this is one of the few times of year that I see these people I love the most. What's even more strange is that the very thing bringing us together is food. We share a smile over Aunt Kath's famous stuffing. We laugh together at how Aunt Kristen continues to burn the pecan pie year after year. But best of all, this meal brings us together to remember the people who used to sit and laugh and smile at this very table right beside us. It unites us in a feeling of overwhelming love as we cherish memories that we will share for the rest of our lives. And as I look around at each smiling face, I realize that each and every person at this table means something different to me, and I'm grateful that we have this day to remind me what I have to be thankful for.


text:
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Western Europe Printer Market Shares, 2018: Single-Function Printers Declining
By: Julio VialQuarterly Research Manager, European Quarterly Printer Market Tracker
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"IDC expects single-function printers to shift to higher-speed segments at the expense of lower-speed segments. This will further cannibalize printers," said Julio Vial, research manager, IDC IPDS Group.
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List of Tables
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text:
Needlepoint canvas is a mesh of horizontal (warp) and vertical (weft) threads. There are several types of needlepoint canvases and the most basic feature that distinguishes one type from another is the manner in which the canvas is woven.
- Mono or single canvas. This type of canvas has single vertical and horizontal threads that are simply woven but not interlocked. In other words, the warp and weft threads alternate in lying under and over one another. Any project in mono canvas should be worked in a stretcher frame, as this type of canvas has the tendency to distort. An advantageous feature is that even if the stitched piece is distorted, it can be blocked back into shape since the canvas threads can move. Mono canvas ravels and you need to stabilize the edges.
- Interlock canvas. This type of canvas seems in appearance like mono canvas, though each intersection consists of two thinner weft threads and one thicker warp thread. However, interlock canvas is a more stable mesh than mono. This happens because of the two horizontal (weft) threads: the one goes over the warp thread while the other goes under. The drawback of this canvas is that due to the locked intersections it is more difficult to bring a distorted stitched piece back to shape. Interlock canvas does not ravel easily.
- Double or Penelope canvas. This type of canvas is made up of pairs of vertical and horizontal threads. An advantageous feature is that this canvas type, allows the stitcher to either stitch over sinlge threads for finer stitching or over pairs of threads when no detail is needed. The first type of needlework is called petit point. If the stitcher uses all holes then the mesh count increases. That is why penelope canvas is sometimes labelled with two numbers- e.g 14/28. The threads of Penelope canvas are not intelocked because they are woven like mono canvas with one thread over and one under.
There are are other canvases too, but all of them are woven in one of these three ways. For example solk gauze and garment canvas are types of interlock canvas.


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Today is the first day of rehearsal for our Midsummer of Love! We're diving into design presentations and learning the basic moves of our Bergomask. We're soaking in Strawberry Hill with all of our senses - so that we can share some magic there with you this summer!
We need a bit of pixie dust from your pockets to tickle our wings. Kick us just $5 or $50 and we will spin it into gold (and glitter too perhaps). Please join us on Kickstarter and join the ranks of the esteemed foundations who believe in our work and who join us in creative risk-taking.
We are so immensely grateful for the support we receive from each and every one of our community members - - - from our loyal family of patrons to those just discovering We Players, as well as the local and national organizations that are committed to funding innovative work that enlivens and inspires.
Such forward-thinking institutions as the National Endowment for the Arts, the Kenneth Rainin Foundation, and the San Francisco Arts Commission were the pillars of support of our recent BEOWULF. These organizations know that risky, brave, new work and cross-discipline collaboration is necessary for challenging and shaping our cultural landscape.
We are honored to add our name to the list of arts organizations to which the NEA has granted funding, totaling over five billion dollars in its fifty-two years. The Rainin Foundation, based locally in the Bay Area, provides space and funds to companies that they feel "push the boundaries of creative expression". Our friends at the the San Francisco Arts Commission believe in the creation and strengthening of community through an investment in the arts. We believe in art, now more than ever, that delves and questions and pokes and prods, that leaves us unsettled. Thank you to those individuals and organizations that continue to take risks with us!
We expect our upcoming Midsummer of Love will be a wild and wondrous mix of joyous delight and provocative edge-testing. We hope you'll join us for a romp in the woods this summer.
We Players was recently recognized by Backstage.com as one of seven companies around the globe producing groundbreaking immersive theatre. We Players was featured in American Theatre Magazine's cover story on immersive theatre and was honored by San Francisco Magazine with the "Best of the Bay" pick for their unique site-specific performance work noting, "We Players didn't just break the fourth wall, it toppled the whole playhouse." We Players has received several "Best of Bay" awards from SF Weekly, including this mention in their 2015 award: "We Players actors have the ability to draw power out of their surroundings, channeling it into spectacular, immersive experiences for audience members unlike anything you'll see on Broadway."
We Players creates site-integrated performances that transform public spaces into realms of participatory theatre in an effort to engage with history and the environment, build community, and activate personal relationships with place. Our work inspires, awakens the senses, and connects people with each other and the landscape. We Players is a Bay Area arts non-profit founded in 2000 at Stanford University by Ava Roy. For more information about We Players, please visit www.weplayers.org.


text:
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We will everytime try to help you with your problems with system on our forums.
Tell us your ideas for possible improvements or suggestions for new functionalities! What do you miss and what would you like to see.
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text:
ATHENS (Reuters) - Greece's primary budget surplus has exceeded expectations and will allow the government to boost social spending on austerity-hit citizens, Prime Minister Antonis Samaras told a newspaper.
The primary budget surplus for 2013, which excludes interest payments and other one-off items, has come in at over 1.5 billion euros ($2.1 billion), much higher than initial estimates and targets set by the debt-laden country's international lenders, the European Union and the International Monetary Fund.
"The primary budget surplus is much higher than we had initially estimated ... I am telling you now that it exceeds 1.5 billion euros, three times as big as we initially calculated," Samaras said in an interview published in Sunday's edition of To Vima, which hit newsstands on Saturday evening.
A primary surplus is a key condition set by the lenders to grant the country the additional debt relief it needs to make it sustainable. Under the terms of its 240 billion euro bailout, Greece was supposed to reach a surplus this year.
But Athens says it reached a surplus as early as 2013, one year ahead of schedule. Back in October, the government estimated the full-year 2013 surplus at 344 million euros.
Samaras reiterated on Saturday he would use that surplus to alleviate the plight of those hurt by austerity. "This means that we will refund a very large amount to society this year, for example to low-income pensioners and law enforcement officials," he told the newspaper.
The bailout's terms allow Athens to retain and spend as it wishes 70 percent of any excess primary surplus above its targets.
Samaras' fragile coalition government is trailing the anti-bailout leftist Syriza party in the polls and faces crucial, twin municipal and European elections in May. A bad showing in the vote could destabilize his government, which has a paper-thin three-seat majority in parliament.
But EU officials warned last week that any estimate about the size of the expected surplus is premature until April, when the EU's statistics agency Eurostat will officially sign off on the country's budget figures.
"It is very astonishing to have an opinion on the surplus that early in the year," a senior EU official told reporters on condition of anonymity.
($1 = 0.7307 euros)
Reporting by Harry Papachristou and Martin Santa; Editing by Kevin Liffey and David Evans


text:
Release Date: 2013 |
Nooooooooo loooooooooove
Album Rating: 4.0Album sucks now.
Digging: Cradle of Filth - Cruelty and the Beast - Re-Mistressed
Album Rating: 3.5gota check
Album Rating: 4.0Sonic you'll dig this hard.
Album Rating: 4.0This is borderline 4.5 for me whereas Macabre Eternal is like low 3.5. Just my opinion though.
Album Rating: 4.0Skele just ruined this album for me
"A band held in as high regard as Autopsy should be a band that rarely slip up in their musical career."
Album Rating: 3.5dunno if you were going for a mindfuck for the opening line skele but it worked
Skele you have 2 reviews right now to each other on the front page; what the fuck?
You should have your reviews make more sense in the future then
Album Rating: 3.5how about stop whining like a bitch
Skele why'd you delete your comment =[
dude what is everyone freaking out about, the fact that he left out an s at the end of slip?
album rules, fuck comments saying anything else
^ hmmmm
Digging: Bladee - Working On Dying
this review is a sea of bad metaphors dried overused
but its not worthy of 7 negs :/
lol another thread to ruin
defile em all
artwork sucks
it's ok
all that matters are the riffs m/ for real gota dl this
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


text:
How incredibly unfit this woman is for the most stressful job in the world.Hillary Clinton 9/11 NYC pic.twitter.com/q9YnsjTxss— Zdenek Gazda (@zgazda66) September 11, 2016
This is Hillary Clinton leaving her daughter Chelsea's apartment a little over an hour ago. My God, she can't even get into a car without falling flat on her face. She claims she "overheated." On a breezy, 83 degree day. I guess she hit her head a little too hard breaking that glass ceiling.
She can't even stand up on her own two feet even with the Secret Service closing ranks around her. How the fuck is she going to stand up for your or this country's best interests?
(Update: An anal ex-reader grasping at straws informs me Clinton was leaving the 9-11 memorial service, not her daughter's apartment. Which totally changes everything and therefore makes her fit to be President.)


text:
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Here we are again, and good morning! Everyone ready to dive back into the work week, full of ideas and bristling with competence?
Good lord, I hope not. I'd be ashamed of you, I really would.
I prefer to imagine you facing Monday morning just as I do: through eyes narrowed by suspicion and learned mistrust, sidling up to each task with perfect awareness of how horribly it can go wrong and absolute willingness to abdicate all of your adult responsibilities for the warm embrace of your bed.
In fact, you've probably guessed that I scheduled these posts ahead of time; as I've mentioned before, I greet each new day like a vampire with a paper route – complete with hissing and snarling – and generally will just read in bed until something really urgent forces me to get up (generally it's the bladder).
You see? You know me so well already that I hesitate to mention this trifle, but it is on The List and… well… I suppose it's important that you understand just how different we really are, you and I.
Now, you've probably looked over that list and said to yourself, "yeah, fine, I've not had these exact arguments, but the fundamental principle is the same." I must correct this assumption, dear reader; you have, I'm sure, gotten into it once or twice with your significant other and been unable, once the dust had settled and doors repaired, to justify the precise escalation of events. That's fine – normal even! – but unless you've ended a grocery trip by chucking a cooking pot at your husband (dented it forever, too) then you're not really playing on the same field, are you?
Aaaand now you're sitting back and thinking to yourself "I've been following the rants of a lunatic all along!" Please, don't click away or unsubscribe just yet. Because this is about avocados.
ME: Did you get the avocados?
HIM: Yep (holds out bag)
ME: … what the shit is this?
HIM: Avocados?
ME: They're bright green.
HIM: Yeah. I had to hunt for them, too.
ME: I needed avocados to make guacamole. Tonight.
HIM: Right. Did I not get enough? I thought three would be enough.
ME: These are bright green and rock hard.
HIM: They're the best I could find! Most of the ones in the store were darker and kind of soft!
ME: (pained whimper)
HIM: They'd have been all mushy!
Here followed a free exchange of information and opinions, in which my "it's common fucking sense!" was pitted against his "then why didn't you go get them???"
It was, without exaggeration, one of the most epic fights of our entire marriage.
We were asked once, in a sharing sort of moment, what it is we fight about most. Now, everyone else fights about money but that's not for us: we've got the money we've got, and the bills we've got, and we're pretty much in that boat together no matter what, so arguing about money is sort of foreign to us. Other couples have told us that they argue about each other's annoying habits, but we're far too interested in laughing at those to ever build up any steam over them. No, we had to go all out over avocados.
Beat that.
Oh, and after all these years?
ME: And after all that, you still can't pick out a good avocado!
HIM: I know what I'm looking for now, though. They need to be really dark, wrinkly, and soft.
ME: (clenching)
HIM: And, if all else fails, I get an ugly avocado, and an uglier avocado, and…
ME: (laughing)


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So you are finally making the trip to Buenos Aires and you want to really go all out for this trip. Luxury hotels may be your preference but there is also a wide assortment of penthouse rentals in Buenos Aires, Argentina that take luxury to a different level. One of the best ways to find a great deal is to do your research before making a commitment and check out the online forms of people who have previous experienced penthouse rentals in Buenos Aires.
As you do your research you will find there are a number of great online sites to rent apartments and penthouses in Buenos Aires. The prices will vary depending on the area in which you choose to stay. Palermo Hollywood, Palermo Soho and Recoleta are among the most popular areas for penthouse rentals in Buenos Aires, Argentina.
The Palermo Soho area is very artsy, whereas Palermo Hollywood is active with restaurants and bars. The neighborhood of Recoleta is comparable to the suburbs in that it is an exclusive well-established area with families. It is also a very safe area. Decided on the area that best fits your lifestyle so that you will enjoy your choice of penthouse rental in Buenos Aires.
Read: lugares turisticos en entre rios en invierno
What can you expect in terms of price? Prices will definitely run the gamut for a penthouse rental. Many owners will rent for only weeks or months at a time, and others may have a daily rate. For certain penthouse rentals in Buenos Aires are very high-end, very well appointed, and the amenities are incredible. If you are going with a group of people many of the penthouse rentals accommodate a group of people, which reduces the rate making the stay more affordable.
There are a couple of great places to search for penthouse rentals in Buenos Aires in order to compare prices. A few of the more user friendly sites include Buenos Aires Home and Business which features all areas, pictures, details and availability. There are many sites that offer the same services you just need to determine what you want to spend and be prepared to drop a deposit within 24-hours of making the reservation for your penthouse rental in Buenos Aires. Vacation Rental By Owner is also another great place that offers great penthouse rental deals with details being handled flawlessly. Just do your research and you will have the time of your life while in Buenos Aires.


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I guess Momma already told you about my new tooth! (See post below) That's our big news for today. Mommy said you were sad you weren't here.... Well, don't worry, it's still on it's way out and then I have the right one to work on. I'm sure you'll still be part of the experience! I tried to hold off as long as I could! Mommy said I've been a little fussy for a few days now.
Well, since I took such a big nap today, Mommy didn't get too many opportunities to take pictures. At least that's what she said, but you and I both know that means she only took 50 today instead of her usual 100! In this one she settled for pictures of the doggies since I was asleep: So, what did we do today? Well, after my morning nap we went to Target. I'm sure Momma would have taken pictures there except you know how focused she is when she's at Target! At Target we got a high chair for me! Momma says I'm too big for my bumbo and that we should have gotten it a long time ago, but I'm not sure how I feel about that.... I mean I like my bumbo. I can turn around and see what Baby and Lacy are doing.... I can reach for things next to me....
It's fun!
I guess I'll see how I like that high chair. I told Mommy that I want to wait until you get home though.
Of course I played today. Here are a few pictures of me playing in my room:
In this one I was trying to crawl under the stand that my humidifier sits on.
And in this one I found something that looked really fun but Mommy kept saying, "No no, Tucker." I'm not sure why she wouldn't let me play with these fun things?
Oh, and I started kissing my ottoman. I'm not sure why, I guess I just really like my chair and ottoman... Mommy would say, "Aaahhhh," and I would keep kissing it. Then I started kissing Mommy! She says I'm a sweet boy.Then Papa and Memaw got back from vacation earlier than expected so we didn't need to go let their doggies out, so this evening me and Mommy went to the park and walked with my friend Trey and his Mommy.
It was a busy day, and pretty eventful with my tooth cutting through! Mommy says you're coming home tomorrow! I can't wait! I miss you so much! Mommy tries to make the silly noises like you do, but it's just not the same. I love you, Daddy!


text:
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pilates, the workout intensity & the floating feeling
How great is it to know that exercise and physical fitness are finally becoming an important part of people's daily routine which influences them to take better care of themselves. It is a pleasure to share this desire for healthier life while teaching Pilates, which was created by the very insightful, Joseph Hubertus Pilates (commonly known and titled as Joseph Pilates) who understood the power of having great muscles
endurance, strength and flexibility in order to sustain the day to day strain that life places upon us. Of course, let's not forget the beauty and confidence that comes with it, as well as pride when wearing a beautifully fitting bikini or jeans that accentuate women's figure!
So, whether you are a sports fanatic who enjoys hard(core) workouts or just want to feel the connection of mind and body, the springs will surely make you feel your powerhouse and a great deal of "internal shower" ( rejuvenated blood circulation). And whichever class you choose, rest assured that you will experience the workout intensity as well as the lightness and floating feeling that comes with it! – Jeanique, Pilates Teacher at The Hundred Pilates Studio Dubai.
Jeanique Kalodjera is a former professional dancer, who moved all the way from Mauritius to Dubai nine years ago to perform with her dance troop at Jumeirah Beach Hotel, Burj Al Arab and Jumeirah Beach Club. After an injury, Jeanique discovered the Pilates Method and decided to take on the intensive 12 months program , to obtain a teacher training The Pilates Centerin Boulder, Colorado. After successfully graduating, Jeanique has been enjoying teaching people on how to be in control of their own body, and have a positive mind set in day to day life. To stay close to her artistic roots, Jeanique takes Ballet classes and incorporates Pilates techniques to perfect her moves.


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This Chewbacca has a good amount of gear, a great sculpt, and is friggin' Chewie. On the other hand, the face paint could be better-- you should still look this one up, though. Read on!
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text:
by S. Jae-Jones
Hardcover, 436 pages
Published February 7th 2017 by Thomas Dunne
Wintersong was one of my most anticipated books of the year so going in I had super high expectations which it did not meet. If I did not have those expectations my feelings might be a little different but honestly I can't say for sure. It was good but not great. I felt the story was lacking and the characters I didn't especially enjoy. Going into thinking there was going to be an epic love story only to have really a lack luster couple. I mean sure they were alright but nothing spectacular. It was enjoyable but still nothing really I would seek out again.
The Good:
I love the setting of the story and the fairy tale aspect. It sounded so awesome a story with a Labyrinth feel (such an awesome movie). The characters sounded promising a strong female protagonist fending for her family, and dark mysterous man who you can't help but swoon for, and supporting characters you love. Although they have some feels of this nothing ever really sparked. As I have said before the characters were ok. The Goblin King and Liesel's romance was very little and I never really felt they were right together. Then the supporting characters just didn't fit in as well.
Honestly the story I felt held so much promise it just couldn't hold its own. I could tell she was a Freshman writer. The story itself if a sequel came out I would give it another try although it wouldn't be a book I would actively seek out.
Overall it was just OK not a bad read just not as good as I was expecting. So that dimmed my rating
Top 3 Quotes (this book had a lot of really really good ones )
(These might include spoilers be warned)
"There is music in your soul. A wild and untamed sort
of music that speaks to me. It defies all the rules and laws you humans set upon it. It grows from inside you, and I have a wish to set that music free."
"You are a man with music in his soul. You are capricious, contrary, contradictory. You delight in childish games, and delight even more in winning. For a man of such intense piety, you are surprisingly petty. You are a gentleman, a virtuoso, a scholar, and a martyr, and of those masks, I like the martyr least of all. You are austere, you are pompous, you are pretentious, you are foolish."
"What is eternal life but a prolonged death."


text: Cancer Lung Cancer Print What It Means If You Have Precancerous Cells By Lynne Eldridge, MD Updated September 26, 2019 Medically reviewed by Doru Paul, MD on November 04, 2019 More in Lung Cancer Non-Small Cell Small Cell Causes & Risk Factors Symptoms Treatment Diagnosis Living With Support & Coping In This Article Table of Contents Expand Definition Dysplasia Diagnosis Causes Precancerous Conditions Latency Period When Do Cells Become Cancerous? Symptoms Treatment Progression Terms Reducing Your Risk View All Back To Top The term "precancerous cells" can be scary, and it's important to begin talking about these cells by saying that not all precancerous cells turn into cancer. In fact, most do not. Precancerous cells are abnormal cells that are found on the continuum between normal cells and cancer cells, but unlike cancer cells, do not invade nearby tissues or spread to distant regions of the body. There are many potential causes of precancerous cells ranging from infection to chronic inflammation. Many people have heard of precancerous cells of the uterine cervix that are found during Pap smears, but precancerous cells may occur in nearly any region of the body: the bronchi, the skin, the breasts, the colon, and more. Let's begin by describing the characteristics of these cells are and how they differ from "normal" cells in our bodies. Definition Precancerous cells (also called premalignant cells) are defined as abnormal cells that could turn into cancerous cells but which by themselves are not invasive. The concept of precancerous cells is confusing because it isn't a black-and-white issue. In general, cells don't go from normal on day one, to premalignant on day two, and then on to cancer on day three. Sometimes precancerous cells progress to cancer, but more often they don't. They may stay the same—that is, remain abnormal but not invasive—or they may even become normal again. This last comment is something relatively new to cancer researchers. In the past, it was believed "the damage was done" when a cell was transformed to a precancerous state by carcinogens in the environment. We are now learning (in a field called epigenetics) that our cells are more resilient than that and factors in our environment (whether carcinogens, hormones or perhaps even stress) work together to determine what direction abnormal changes in a cell may go. It's important to emphasize again that cells that are precancerous are not cancer cells. This means that left alone, they're not invasive—that is, they will not spread to other regions of the body. They are simply abnormal cells that could, in time, undergo changes that would transform them into cancer cells. If precancerous cells are removed before they become cancerous, the condition should, theoretically, be 100 percent curable. That said, not all precancerous cells need to be immediately removed. Another point of confusion is that cancer cells and precancerous cells can co-exist. As an example, in some people diagnosed with breast cancer, there are other regions in the breasts and even in the tumor itself in which precancerous cells are found as well. In many tumors, both malignant and premalignant cells are found. Degrees of Dysplasia Changes The word dysplasia is often used synonymously with precancerous cells, yet there are a few differences. When doctors speak of dysplasia, they are speaking of abnormal cells that could become cancerous. But in some cases, the words severe dysplasia are used to describe cells that are already cancerous but contained within the tissues in which they began—something known as carcinoma-in-situ. Precancerous changes are usually described in degrees or levels of abnormalities. There are two primary ways that these are described: severity and grade. Severity Mild dysplasia: Mild dysplasia refers to cells that are just slightly abnormal. These cells do not usually progress to cancer.Moderate dysplasia: These cells are moderately abnormal and have a higher risk of developing into cancer.Severe dysplasia: This is the most extreme abnormality seen before a cell would be described as cancerous. Severe dysplasia is much more likely to progress to cancer. An example that might make this clearer is the cervical dysplasia found on some Pap smears. Cells that are mildly dysplastic rarely become cancerous. On the other hand, if left untreated, severe dysplasia found on a Pap smear will progress to cancer 30 percent to 50 percent of the time. There is confusion regarding where exactly to draw the line between severe dysplasia and carcinoma in situ. Carcinoma in situ is a term literally translated as "cancer in place." These are cancerous cells that have not yet broken through what is known as the basement membrane. Grades Another way to describe the severity of precancerous changes in cells is by grades. With cervical cells, these classifications are usually used when a biopsy is done after finding dysplasia on a pap smear. Low-grade dysplasia: Low-grade changes are unlikely to progress to cancer.High-grade dysplasia: Cells with high-grade dysplasia are much more likely to progress to cancer. An example of this would be low-grade dysplasia seen on a biopsy of the cervix. The likelihood of these changes progressing to cancer is fairly low. In contrast, high-grade colon dysplasia associated with colon polyps has a high risk of continuing on to become colon cancer. Diagnosis A physical exam or imaging studies may suggest that abnormal cells could be present, but a biopsy is necessary to make the diagnosis. After a section of tissue is removed, pathologists look at the cells under the microscope to look for signs that cells are precancerous or cancerous. Causes There are multiple factors that can cause cells to become precancerous, and these vary depending upon the particular type of cells involved. A simplistic way of understanding causes is to look at influences in the environment that might damage healthy cells, leading to changes in the cell's DNA, which can subsequently lead to abnormal growth and development. A few underlying processes that may cause abnormalities in cells (with a few examples to illustrate) include: Infection: While only 4 to 10 percent of cancers in the U.S. are related to infections, infections with viruses, bacteria, and parasites are responsible for roughly a fourth of cancers worldwide.Infection with the human papillomavirus (HPV) can cause inflammation, leading to precancerous cells in the cervix. HPV is also an important cause of dysplasia that precedes many head and neck cancers, such as tongue cancer and throat cancer. Most infections with HPV clear before any abnormal cell changes take place. If dysplasia develops, it may resolve on its own or with treatment, or progress to cervical cancer without treatment. Infection and subsequent inflammation with the bacteria Helicobacter pylori (H. pylori) can result in chronic atrophic gastritis, an inflammatory precancerous change in the lining of the stomach that can lead to stomach cancer.Chronic Inflammation: Chronic inflammation in tissue can lead to precancerous changes that may in turn progress to cancer. An example is in people who suffer from gastroesophageal reflux disease (GERD) for a prolonged period of time. Chronic inflammation of the esophagus by stomach acids can result in a condition known as Barrett's esophagus. Among people with Barrett's esophagus, approximately one percent per year will develop esophageal cancer. An important area of research is determining whether or not removing areas of high-grade dysplasia will decrease the risk of developing esophageal cancer.Another example is inflammation of the colon in people with inflammatory bowel disease (IBD). IBD can lead to polyps with colon dysplasia, which in turn can eventually lead to colon cancer.Chronic Irritation: Chronic irritation of the airways from tobacco smoke, air pollution, and some industrial chemicals can result in bronchial dysplasia (dysplasia of the bronchi). If this is detected early—during a bronchoscopy and a biopsy, for example—the precancerous cells may sometimes be treated with cryosurgery before they have the opportunity to progress to lung cancer. Types of Precancerous Conditions Cancers which begin in epithelial cells (roughly 85 percent of cancers) may have a precancerous state. This is in contrast to cancers which begin in mesothelial cells such as sarcomas. Some precancerous states were mentioned above, but include: Cervical intraepithelial neoplasia (CIN) - A precancerous state of cervical cancerBarrett's esophagus (abnormal esophageal cells which may go on to become esophageal cancer)Atypical lobular hyperplasia (which may develop into breast cancer)Adenomatous polyps in the colon (which may develop into colon cancer)Actinic keratoses (abnormal changes in the skin which may develop into squamous cell skin cancer)Dysplastic moles (which may develop into melanoma)Bronchial epithelial dysplasia (which may develop into lung cancer)Atrophic gastritis (precancerous changes in the stomach which may develop into gastric (stomach) cancerBowen's disease (precancerous changes that may occur on the vulva or penis) Again it's important to note that precancerous cells may or not may not go on to become cancerous cells. What Is a Latency Period? Discussing precancerous changes is a good opportunity to talk about another difficult-to-understand concept in the development of cancer: latency. The latency period is defined as the period of time between exposure to a cancer-causing substance (a carcinogen) and the later development of cancer. People are often surprised when they develop cancer many years after exposure to a carcinogen; for example, some people are perplexed when they develop lung cancer even when they'd quit smoking three decades earlier. When cells are first exposed to a carcinogen, the damage is done to the DNA in the cell. It's usually an accumulation of this damage (accumulation of mutations) over time that results in a cell becoming precancerous. Following that period, the cell may progress through stages of mild to moderate—and on to severe—dysplasia before finally becoming a cancer cell. The cell may also be exposed to an environment that inhibits its progression to cancer, or even reverts it to a normal cell (why a healthy diet and exercise are important even if you've been exposed to a carcinogen). This is a simplistic way of describing the process, and we are learning that it is much more complex than we once thought. But understanding the precancerous process does help explain the latency period we see with many cancers. When Do Cells Become Cancerous? The answer is that most of the time, we don't know how long it takes for precancerous cells to become cancerous. In addition, the answer certainly varies depending on the type of cell studied. As noted above, cervical cells with severe dysplasia progressed to cancer 30 to 50 percent of the time, but the time frame that this took to happen was variable. In one study looking at 115 people with dysplasia of the vocal cords, 15 went on to develop invasive cancer (one had mild dysplasia, one had moderate dysplasia, seven had severe dysplasia and 6 had carcinoma in situ). In 73 percent of these patients, their precancerous lesions became invasive cancer of the vocal cords within one year, with the remainder developing cancer years later. Are There Symptoms? Precancerous cells are often present without any symptoms. If symptoms are present, they will depend on the location of the precancerous changes. Precancerous changes in the cervix, for example, may cause the cells to slough more easily, resulting in abnormal uterine bleeding. Precancerous changes in the mouth may be visualized as white spots (leukoplakia). Precancerous changes in the digestive tract (such as the esophagus, stomach, or colon) may be seen on procedures such as upper GI endoscopy or colonoscopy. And in regions that are not visible to the naked eye, such as the tissue lining the airways, dysplasia is most often detected when a screening biopsy is done for another reason. Treatment The treatment of precancerous cells will again depend upon the location of the cells. Sometimes close monitoring is all that is recommended to see if the level of dysplasia progresses or resolves without treatment. Often the precancerous cells will be removed by a procedure such as cryotherapy (freezing the cells) or surgery to remove the region in which the abnormal cells are located. Even if the abnormal cells are removed, it's important to keep in mind that whatever caused the cells to become abnormal in the first place may affect other cells in the future, and careful monitoring over the long term is important. For example, if abnormal cervical cells are treated with cryotherapy, it will still be important to monitor for recurrent problems with Pap smears in the future. And if Barrett's esophagus is treated with cryotherapy, you will still need to have your esophagus monitored at intervals in the future. For some abnormalities, your doctor may recommend chemoprevention. This is the use of a medication that reduces the risk of cells' becoming abnormal in the future. An example of this is to treat an infection with the H. pylori bacteria in the stomach. Ridding the body of the bacteria appears to reduce precancerous cells and the development of stomach cancer. Researchers are looking at the use of several medications and vitamins to see if their use in former and current smokers will lower their risk of developing lung cancer in the future. A last and important point to make is a reminder that, in some cases, the progression of precancerous changes may be altered by our environment: the foods we eat, the exercise we get, and the lifestyle choices we make. A diet rich in foods containing certain vitamins, for example, may help the body clear the HPV virus more rapidly. Similarly, avoiding substances that may be responsible for precancerous changes (such as tobacco) may reduce the risk of precancerous cells progressing or the formation of further precancerous cells in the future. An example is the situation with smoking and cervical cancer. While smoking does not appear to cause cervical cancer, combining smoking with an HPV infection increases the chance that a cancer will develop. Precancerous Progression Terms There are many terms describing cells that make understanding this topic difficult, so an example might help make this understanding a little clearer. With squamous cell lung cancer, it appears that cells go through a certain progression before cancer develops. It begins with normal lung cells. The first change is hyperplasia, which is defined as cells that grow larger or faster than expected. For example, hyperplasia of the heart would be the term used to describe an enlarged heart. The second step is metaplasia when cells change to a type of cell not usually present. Metaplasia in the esophagus (which can be a precursor to esophageal cancer), for example, is when cells that look like those normally found in the small intestine are found in the esophagus. The third step is dysplasia, which is followed by carcinoma in situ and, finally, invasive squamous cell carcinoma. Reducing Your Risk It's never too late to adopt preventive practices—even if you've been diagnosed with cancer. People who have cancer can also benefit from learning about cancer risk reduction or the reduction of recurrence through diet and exercise. Take a moment to check out tips on reducing your risk of cancer, which can be helpful in reducing lung cancer and other cancers, as well as dietary superfoods which may help to lower your risk of either cancer or cancer recurrence. What is a colposcopy? Was this page helpful? Thanks for your feedback! Limiting processed foods and red meats can help ward off cancer risk. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Sign up and get your guide! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Chen, L., Shen, R., Ye, Y. et al. Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation. PLosOne. 2007. doi.org/10.1371/journal.pone.0000293 Keith, R. Lung cancer chemoprevention. Proceedings of the American Thoracic Society. 2012. 9(2):52-6. Rohde, M. et al. Aggressive elimination of precancerous lesions of the vocal cords to avoid risk of cancer. Danish Medical Journal. 2012. 59(5):A4399. Seo, J. et al. Eradication of Helicobacter pylori Reduces Metachronous Gastric Cancer after Endoscopic Resection of Early Gastric Cancer. Hepatogastroenterology. 2012. 60(125). Toll, A. et al. Prognostic significance of high-grade dysplasia in colorectal adenomas. Colorectal Disease. 2011. 14(4):370-3. Continue Reading


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Milt Zaslow Award Honors Maryland History Day Winners in Cryptology
Mr. Milton Zaslow
The National Cryptologic Museum Foundation established the Milt Zaslow Award for Cryptology for the Maryland History Day Contest with the Maryland Humanities Council (MDHC). This annual statewide contest involves over 450 students, 85 judges, plus parents and teachers. The winners go on to represent Maryland at the National History Day contest in June.
During the contest, there are categories for Junior and Senior school participants. Judges have guidelines for a variety of subjects, including the Milt Zaslow Award for Cryptology that focuses on cryptologic topics.
During Milt's tenure as the Recognitions Committee chairman, he took great interest in the program and on several occasions served as a contest judge for cryptology. Milt was inducted into the NSA/CSS Cryptologic Hall of Honor in 2007. Read more about him HERE.
2016 Milt Zaslow Award Winners
Congratulations to the 2016 winners of the Milton Zaslow Award for Cryptology!
Ms. Kelly McGovern, Junior Level Award Winner, for her performance of "The Limping Lady: Virginia Hall, the Most Dangerous Allied Spy of World War II." Ms. McGovern is from Frederick County - Frederick Homeschoolers and her teacher is Ms. Christine Pritt.
Ms. Megan Tatum and Ms. Alice Walker, Senior Level Award Winners, for their performance of "Running Out of Time: The Forgotten Polish Exploration of Enigma." Ms. Tatum and Ms. Walker attend Poolesville High School in Montgomery County, MD. Their teacher is Mr. Daniel McKenna.
2015 Milt Zaslow Award Winners
CONGRATULATIONS to the following winners of the 2015 Milt Zaslow Award in Cryptology!
Senior Division: Students - Alan Gorny and Srinayan Nuvvala, Documentary - "Alan Turing: Codebreaker." From Howard High School in Howard County. Teachers - Danelle Brennan and Mary Curtin.
Junior Division: Student - Grady Fort, Created a Web site - "Alan Turing: An Enigma No More." From Southern Middle School in Calvert County. Teacher - Melissa Kallfelz.
2014 Milt Zaslow Award Winners
Senior Division: Mr. Jeremy Davis was selected as the winner for his presentation, The NSA Scandal. Mr. Davis attends Bohemia Manor High School in Cecil County and his teacher is Mr. Michael Means.
Junior Division: Ms. Carlie Domogauer and Ms. Kristen Tull were selected as the winners for their presentation, Women Spies. Ms. Domogauer and Ms. Tull attend Matapeake Middle School in Queen Anne's County and their teacher is Ms. Jillian Ferris.
2013 Milt Zaslow Award Winners
The 2013 Milt Zaslow Award Senior Division Winners were students from Polytechnic Institute in Baltimore, Maryland with their exhibit about "The Effect of the Navajo Code Talkers on U.S. - Native American Relations After WWII." Both the Senior and Junior winning exhibits were on display at the NCM for two weekends and the students were on hand to discuss their work and answer questions.
The 2013 Milt Zaslow Award Junior Division winners were students from Matapeake Middle School in Stevensville, Maryland. Their winning exhibit focused on the Navajo Code Talkers.
The ten-year grant was made possible by the generosity of the Foundation's general membership and the family of Mr. Zaslow who contributed to the Foundation's In Memoriam Program to commemorate Mr. Zaslow's many contributions to the field of cryptology. The Foundation decided that the most fitting memorial of all would be to establish a monetary award, the Milt Zaslow Award, honoring and encouraging Maryland History Day Contest participants who submit work focused on cryptology.


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Porter, David, Faivre, Emilie, Flatt, Peter, Holscher, Christian and Gault, Victor (2012) Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. PEPTIDES, 35 (1). pp. 1-8. [Journal article]
Full text not available from this repository.
DOI: 10.1016/j.peptides.2012.03.014
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) improve markers of cognitive function in obesity-diabetes, however, both are rapidly degraded to their major metabolites, GLP-1(9-36)amide and GIP(3-42), respectively. Therefore, the present study investigated effects of GLP-1(9-36)amide and GIP(3-42) on locomotor activity, cognitive function and hippocampal synaptic plasticity in mice with diet-induced obesity and insulin resistance. High-fat fed Swiss TO mice treated with GLP-1(9-36)amide, GIP(3-42) or exendin(9-39)amide (twice-daily for 60 days) did not exhibit any changes in bodyweight, non-fasting plasma glucose and plasma insulin concentrations or glucose tolerance compared with high-fat saline controls. Similarly, locomotor and feeding activity, O-2 consumption, CO2 production, respiratory exchange ratio and energy expenditure were not altered by chronic treatment with incretin metabolites. Administration of the truncated metabolites did not alter general behavior in an open field test or learning and memory ability as recorded during an object recognition test. High-fat mice exhibited a significant impairment in hippocampal long-term potentiation (LTP) which was not affected by treatment with incretin metabolites. These data indicate that incretin metabolites do not influence locomotor activity, cognitive function and hippocampal synaptic plasticity when administered at pharmacological doses to mice fed a high-fat diet. (C) 2012 Elsevier Inc. All rights reserved.
|Item Type:
|Journal article
|Faculties and Schools:
|Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences
|Research Institutes and Groups:
|Biomedical Sciences Research Institute > Genomic Medicine
Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
|ID Code:
|Deposited By:
|Dr Nigel Irwin
|Deposited On:
|31 Jul 2012 09:22
|Last Modified:
|31 Jul 2012 09:22
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