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The procedure can be a bit hit and miss, reaching some cells but not others. Even when Crispr gets where it is needed, the edits can differ from cell to cell, for example mending two copies of a mutated gene in one cell, but only one copy in another. For some genetic diseases this may not matter, but it may if a single mutated gene causes the disorder. Another common problem happens when edits are made at the wrong place in the genome. There can be hundreds of these "off-target" edits that can be dangerous if they disrupt healthy genes or crucial regulatory DNA.
Another controversial milestone is applying this technology in embryos with the added advantage that any edits will be passed on to future offspring [together with any undesirable off-target effects]. This is not science fiction, I repeat. In 2017, Nature published research relating to gene editing in embryos made with the sperm of a man who inherited a heart condition known as hypertrophic cardiomyopathy.4 When the scientists made embryos with the man's sperm and healthy eggs from donors, they found that, as expected, about 50% of embryos carried the mutant gene. If the affected embryos were implanted into women and carried to term, the resulting children would inherit the heart condition. The researchers describe how gene editing, when performed early enough, at the same time as fertilisation, 42 out of 58 embryos, or 72%, were found to be free of the disease-causing mutation. Also in 2017, a similar technology, base editing, has been used to fix defective β-thalassaemia genes in human embryos.5 Base editing, differs from gene editing in that it does not cut the double helix, but instead uses enzymes to precisely rearrange some of the atoms in one of the four bases that make up DNA or RNA, converting the base into a different one without altering the bases around it.
I know that discussing ethical issues merits more than a few words but let us consider the fact that today, people who carry certain genetic diseases prefer to opt for IVF and have their embryos screened for harmful mutations. If mutations are detected, these embryos are wasted. In specific scenarios, gene editing can help increase the number of embryos for implantation since this technology can eliminate such mutations.
The ramifications arising from such technology are infinite, including gene drives. Engineered gene drives have the power to propagate particular genes through an entire population of organisms, e.g. by implanting a fertility-reducing gene in malaria-carrying mosquitoes with a view to eradicate malaria. But still, this technology is controversial because it can have massive unintended ecological consequences.
- Qasim W, Zhan H, Samarasinghe S, et al. Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Sci Transl Med 2017;9(374).
- Tebas P, Stein D, Tang WW, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med 2014;370(10):901-10.
- Amoasii L, Long C, Li H, et al. Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy. Sci Transl Med 2017;9(418).
- Ma H, Marti-Gutierrez N, Park SW, et al. Correction of a pathogenic gene mutation in human embryos. Nature 2017;548(7668):413-419.
5. Liang P, Ding C, Sun H, et al. Correction of β-thalassemia mutant by base editor in human embryos. Protein Cell 2017;8(11):811-822.


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Inaugural Mini-Series ~ Episode II: "Excelling at Customer Service — A 1/2 Pint of Ideas"
Customer Service Award for Episode II: Equinox Brewing of Fort Collins
Information saturation is a wonderful thing. Beer enthusiasts are traveling around drinking all varieties of beer to not only enjoy a good lager or ale, but to also be educated about what different breweries are doing with both common styles and crafty brews. In every glass of beer there's a lesson, a story, a detail that's important and that will positively affect the tasting experience. This information might range from an ingredient list to IBUs or ABV to the genesis of the beer's name to the specific stylistic approach of the brewer.
My tasting days began in wineries, and as we traveled the Central Coast of California in June, I was reminded that nearly every winery offers a tasting sheet that explains the many elements of each wine to the customer. And while a few breweries offer similar detail, (like Elevation Beer Company of Poncha Springs) many do not. I wonder why.
In lieu of a tasting sheet, some breweries have highly trained bartenders and servers who can be quite helpful when you have questions (like Grimm Brother's Brewhouse of Loveland). I am always surprised though when we come across someone pulling the tap handle who doesn't know the main hop or malt profile in a beer, let alone the intricacies of the particular style.
So what can breweries do to answer the call for information saturation? 1) Offer a detailed tasting sheet/notes for their regular beers with a secondary temporary sheet for seasonal, specialty or pilot beers, and 2) spend a bit of time training staff about the house beer and encourage staff to continually expand their knowledge about what's on tap.
Beer might be the great social elixir, the foundational community builder, the tastiest drink on the planet, but it is also a product being sold in a highly competitive market. Customers need information to know what they're going to buy and why they want to come back and drink some more of it.
Explanation of Customer Service Posts: At Colorado Brewery Days we strive to remain positive in our writing about beer and breweries. Our goal is not to offer criticisms on beer, but to advocate for the craft beer scene, particularly in Colorado. After visiting just about every brewery operation in the state, (and several more all over the country and world), we felt that we might be able to provide some ideas for breweries to increase their success as a small business. We will never point out a brewery that doesn't do things quite as well as they might, but we always provide an example of a brewery achieving a high level of customer service in a particular area (presented in our weekly award). Please let us know if you have questions or if we can help brainstorm additional ideas or advice.

subset: commoncrawl


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Last week I answered a common question I get from clients, "Can we sell unsold silent auction items before or after the live auction?" My answer was "NO!" However that leaves us with a conundrum: what can we do with unsold live auction items??
Lots of things!
- Remove minimum bids: You can decide at a certain point in the night that any silent auction items that have not been bid on, no longer have a minimum bid. It may be that for some of those more quirky donations, the valued minimum bid may have been too high to entice any bidders. If your concern is just getting those items out of your hands that night, this is the best option.
- FIRE SALE: Hosting an online fire sale on your organization's auction site after the auction is a great way to manage any items that did not sell. This works with organizations that opt to use mobile bidding software. Companies like BidPal will work with you to create a specific auction site where people can register for the event, get updates and bid on items before or after the auction (if you choose to make it available). You will most likely get more revenue from this than you would with our option #1.
- Sell the items at an external site (like ebay or craigslist). This takes more effort, but it opens up your bidding audience to people looking for those specific items. I wouldn't take the time to do this with all the items, but if you have anything that is of higher value, but requires the bidding of specific tastes (art, jewelry, furniture, sports memorabilia, etc), this would be worth your time to try to reach those people for the sake of your organization.
If you have questions about your silent auction, I can work with you to answer those as well as things related to your live auction.


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If you're a follower of Christ and are wanting to take your relationship with Christ to the next level - this is the message for you. The first step? Surrendering control. It's one thing to bring Him the broken things, but he wants us to give up control of the good things too. We can trust His dreams over our own!
"Then Jesus went to work on his disciples. "Anyone who intends to come with me has to let me lead. You're not in the driver's seat; I am. Don't run from suffering; embrace it. Follow me and I'll show you how. Self-help is no help at all. Self-sacrifice is the way, my way, to finding yourself, your true self." Matthew 16:24-25Read More


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Zion Narrows is a canyoneering adventure that will require 8 to 12 hours to complete for experienced hikers. The less experienced, high water (above 50 cfs) or muddy water conditions will require additional time. The total route is 16 miles long. This route is commonly done as a two day backpack, which allows more time to explore and admire the scenery. A car shuttle is required for this adventure. Trailhead shuttle information is available.
Zion Narrows is rated 1C IV using the Canyon Rating System. You will need a Zion backcountry permit for this canyon. Zion Narrows has a high flash flood danger, check the weather report at the Visitor Center when you pick up your permit.
You will need a hiking staff or trekking poles to provide sure footing during the miles of river hiking. An old pair of ski poles also work great. You will want to pack everything that is to stay dry into drybags. Visit my gear suggestions for the proper footwear and clothing, this is not a technical canyon so many of the items in the gear section are not required but are still worth reading about to gather ideas for enjoyable wet canyoneering.
Zion Narrows
requires many miles of wading with depths up to chest deep combined with a couple of
possible short swims. If required, the swimming is never further than 10 to 15 feet. The
water is cold and a hot day is suggested. Everyone will want to carry a warm, dry fleece
to put on if they become chilled or at the canyon end so toss one into your drybag.
The following is a list of campsites and size:
Campsite #1 - 4 People
Human Waste Disposal:
The National Park Service has introduced a human waste disposal program for overnight users in the Narrows. An environmentally friendly human waste disposal bag, complete with use and disposal instructions, will be provided to all party members with every Narrows overnight permit. The bag is called Restop 2. It is a lightweight, sanitary way to pack out waste. The bag within a bag design and ziplock closure securely contains waste and odor, while the special blend of polymers instantly breaks down waste and turns it into a deodorized gel. The contents of the bag are safe for landfills and may be deposited in the trash. Use of this waste disposal system is strongly encouraged as a means for protecting the Virgin River.
From the East Entrance of Zion National Park, drive east 2.4 miles on highway 9. Turn left (north) at the signed "North Fork" junction. Drive 18 miles north (The first 5.5 miles of road are paved) until you encounter a wooden bridge that crosses the North Fork of the Virgin River. Just beyond the bridge turn left on a smaller dirt road and follow it for 0.5 miles to a gate that allows access to Chamberlain's Ranch. Continue through the gate and follow the dirt road for an additional 0.5 miles to the trailhead. The trailhead is identified as where the road crosses the river with a sign and trail register. Please close all gates behind you and remember that you are on private property so show the proper respect.
Any vehicle can be driven to the trailhead with no problems during dry conditions. This road becomes impassable to all vehicles (including four wheel drive) during wet conditions.
From the Upper Trailhead (N37° 23' 06", W112° 50' 20") follow the dirt road across the stream. After hiking down the road for 1 1/2 miles past irrigated pastures you will encounter the rustic Bulloch Cabin.
Just keep hiking downstream and you will not get lost. The canyon will begin to slot up and 5 miles from the trailhead you will encounter Simon Gulch (N37° 22' 16", W112° 54' 45") entering on the right (LDC). 1 1/2 miles below Simon Gulch you will reach a 12-foot waterfall. The waterfall is bypassed using an obvious route to the left (LDC).
8 miles from the trailhead Deep Creek (N37° 21' 33", W112° 57' 06") joins from the right (LDC) with the North Fork and the water volume more than doubles. This is the half-way point mileage wise of your trek but not time wise. 1 1/2 miles below the Deep Creek junction the notorious Kolob Creek (N37° 20' 57", W112° 57' 03") enters on the right (LDC). Just after leaving Kolob Creek and you will have reached the half-way point time wise in your adventure. 1 1/4 miles below Kolob Creek you will meet Goose Creek (N37° 20' 18", W112° 57' 26") entering from the right (LDC). Each of these side canyons add to the water volume in the Virgin River.
3/4 miles below the Goose Creek junction you will enjoy seeing Big Springs (N37° 19' 52", W112° 57' 25") spouting from the canyon wall. There is a small amount of poison ivy in the canyon between Goose Creek and Big Springs so use caution. No camping is allowed below Big Springs. The next 2 miles to the junction with Orderville Gulch (N37° 18' 28", W112° 56' 48") is the narrowest portion of "The Narrows".
At the Orderville Gulch junction you should begin meeting a flock of tourists who have hiked up canyon from the Temple of the Sinawava. It is at this point in the route where you might possibly encounter the scariest item on your adventure and that would be middle aged European men with beer guts hiking in Speedo swimming suits. Do not look directly at them or you could go blind. You have been warned. 1 1/4 miles below the junction with Orderville Gulch you will notice Mystery Falls (N37° 17' 57", W112° 56' 40") exiting from the hanging Mystery Canyon and flowing down the left side (LDC) canyon wall. At this point the flock of tourists hiking up from the bottom has now turned into a thundering herd. 1 1/4 miles below Mystery Falls you will reach the Temple of the Sinawava (N37° 17' 07", W112° 56' 52") and the shuttle bus. Ride the shuttle bus back to the Lower Trailhead and your waiting vehicle at the Zion Canyon Visitor Center.
[ Homepage ] [ Introduction ] [ Warning ] [ Ratings ] [ Ethics ] [ Feedback ] [ Updates ]
© Copyright 2002-, Climb-Utah.com


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The topic of executive compensation has once again hit the front pages, and with more heat than light. Adding fuel to the fire is the return of profitability of major banks, whose lavish pay scales at the top make ordinary people (and not a few professors) drool with envy. So we face this challenge. How exactly can regulators constrain pay without wrecking the entire financial sector?
I suspect that no collective mandate can do the job, either by controlling the mix of present and deferred benefits, or by imposing hard wage caps. Economist turned populist Ben Bernanke has a better idea. He thinks he can remove one set of imperfections from the executive compensation market without creating a second set. I have already expressed my doubt on this score. Alas, it is time to do it again.
Start with Bernanke's critique: "Compensation practices at some banking organizations have led to misaligned incentives and excessive risk-taking, contributing to bank losses and financial instability." Then comes the punch line: "The Federal Reserve is working to ensure that compensation packages appropriately tie rewards to longer-term performance and do not create undue risk for the firm or the financial system."
The first sentence has some truth; the second is the pie-in-the-sky. Wherein lies the disconnect? Start with the innocent word, "some." Some lies somewhere between all and none. That covers a lot of territory, but it does answer two pesky questions: How many banks? And which ones? Answering the first question gives some hint as to whether it pays for the Federal Reserve to gear up its oversight campaign. If some means two or three, Bernanke and company are on a fool's errand. Yet if the number of badly run banks is 10 or 12 , the "which" question comes to the fore. Who in government has reliable and timely information to distinguish banks with defective compensation programs that worked from those with sound executive compensation programs that were overwhelmed by external events? Probably no one.
The requisite information is hard to gather, especially at a distance. Past track record won't tell a lot, especially if the management team has turned over in the interim. Poring over quarterly reports just places a premium on stale information of no relevance in evaluating an individual employee's future performance. Bernanke's fledgling bureaucrats have only a snowball's chance in hell of isolating either delinquent firms or incompetent employees.
Just for fun, now suppose that the Fed's sleuths find the true offenders. Now how do they "ensure" that appropriate compensation programs are in place? First, do the Fed's operatives even know what an appropriate compensation program for key employees looks like? This is a tall order with many moving parts. The common suggestion, that the firm defer payment to see how the employee's early bets turn out, won't do the job. If the deferred payments are fixed, they won't vary with future performance, so why wait? And if they do vary, they could rise or fall on the backs of others long after their departure. How can any regulator divine the right mix?
You do the math: at present 28 banks are in line for a Fed redo, with, say, 100 top employees each. Can the Fed oversee 2,800 multi-year compensation packages in a timely and accurate fashion, when its own intervention is likely to increase corporate uncertainty and turnover? Yet Bernanke speaks only of regulatory success, never regulatory error, which could bring down the institutions he is supposed to save.
For his part, Ken Feinberg, the TARP czar, has the 175 top employees at the seven large TARP corporations in his crosshairs. The public wants a strong say in the operation of large firms rescued with tax dollars. Yet just how should this government investor behave in face of an acute conflict of interest? If Feinberg cares about the share value of a firm in which the U.S. has taken an equity stake, he should behave like a prudent investor. His proper course of action is to acquiesce in any and all lavish compensation packages that he believes will maximize shareholder value. If he cares about political blowback, he must defuse the populist outcry that those hefty compensation packages generate. Well, which is it? Feinberg can't do both at the same time. Rather than try, he should seek to minimize his role, not flex his muscles.
It is not exactly news that no one thinks it is a good idea in principle to let unsuccessful executives reap huge rewards from the companies that they have failed. Unfortunately, the hard matters deal with means, not ends. On those Mssrs. Bernanke and Feinberg sound adamant but clueless. Perhaps it's because politically they are in an enviable position. If the regulated firms mend, our regulators take the credit. If they fail, it proves that additional powers are needed.
To this libertarian, this blind faith flies in the face of experience. The operative norm should be that businesses are imperfect and governments are worse. Accordingly, the lesser (and cheaper) evil is for government to let firms set compensation levels. It is better for our high-profile experts to do nothing than to do something dumb. So into today's political climate, expect something dumb.
Richard A. Epstein is the James Parker Hall distinguished service professor of law, the University of Chicago; the Peter and Kirsten Bedford senior fellow, the Hoover Institution; and a visiting professor at New York University School of Law. He writes a weekly column for Forbes.com.
Read more Forbes Opinions here.


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Muddy Paws Cheesecake is served in some of the Twin Cities best establishments. Please visit them and don't forget to order dessert!
Or feel free to stop by our bakery for cheesecake to go! Just added to list below: Prairie Dog Sausage is now carrying our cheesecake!
Lindey's Prime Steak House3600 North Snelling Avenue
Arden Hills, MN 55112
(651) 633-9813
Birch's On The Lake1310 W Wayzata Blvd,
Long Lake, MN 55356
Gingko Coffeehouse721 Snelling Ave North
St. Paul, MN 55104
(651) 645-2647
Go there for the cheesecake stay for the coffee & live music!


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Mobile apps are growing exponentially ever since their inception. The market for mobile apps is at an inflection point with 31B apps downloaded last year and projected to more than double by 2016. The potential for any developer, big or small, to capture mindshare and marketshare and generate big revenues is huge. Learn how from this infographic by Schools.com
Infographic Credit: Schools.com


text: Straight teeth are important to orthodontic health, by themselves, they don't always produce a Hollywood smile. Some patients develop "black triangles" – small voids between teeth at the gum line. (Orthodontists call these spaces "open gingival embrasures") While open embrasures aren't harmful, some patients think the spaces diminish their appearance. Several different conditions can cause this visual. What causes black triangles? Orthodontic treatment. Patients with … [Read more...]


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"We do not inherit the earth from our parents, we borrow it from our children."
- Wendell Berry
I think we all agree that Earth Day should really be every day, even though tomorrow is the official day. I am very grateful to be raising two righteous, nature-loving, earth-protecting girls. The other day we were on our way to school when we noticed our neighborhood "Bee Tree" (as we call it) had been filled with foam. There were hundreds of dead bees oozing out of the tree and the girls and I were horrified. R is a budding scientist so the impact of this bee massacre really shook her. She felt compelled to say something so she wrote a letter to our neighbors:
Proud Mom.
Here are 5 ways to celebrate Earth Day in addition to art making:
1. Skip the car. Walk, bike, or use public transit.
2. Skip the meat. Even eating a vegetarian diet 1x per week reduces the impact of climate change, rain forest destruction, pollution, and greenhouse gas emission.
3. BYO drink and food containers and shopping bags.
4. Donate:
Wildlife Conservation Network
Sierra Club
The World Land Trust
Environmental Defense Fund
Earth Justice
5. Go paperless. Set up online bill pay for all your accounts.
We are big fans of using recycled materials in our art making. If you are looking for some great up-cycled art projects here are some really fun ones that you can find on our site:
Penguins, Egg Carton Wreath, Jelly Fish, Cardboard House, Cardboard Bird and Cars
Every good celebration calls for some pomp and flair and Earth Day is no exception.
Bring on the Muffin Tin Print... Urfs (as H calls them).
- metal muffin tin
- acrylic or tempera paint (turquoise, spring green, yellow, cobalt blue) + paint brush
- thick white paper
- rainbow string
- wooden beads
- hot glue gun
- scissors
- turquoise bendy wire
- wooden beads
- hot glue gun


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APECS Foundation, a new nonprofit organization dedicated to hunting, outdoor and agricultural heritage, has slated its first fundraiser at 5 p.m. June 7 at the Red Bluff Community Center, 1500 South Jackson St.
The organization goes by APECS for short, but stands for Agricultural Preservation Environmental Conservation Sportsmen Foundation. It is a 501(c)3 nonprofit organization.
The evening includes food, games, drawings, and live and silent auctions.
Tickets are $100 or $150 for a couple. Seating is limited. Ticket information is available from Brian Riley, 529-9435.
Information about the organization is available at www.apecsfoundation.org
A flier states the organization is "… committed to advocating on behalf of our outdoor traditions and protecting our agricultural heritage, all while continuing to promote recreation, conservation, wildlife management, and sustainable natural resource utilization."
A press release states environmental special interest groups in urban California "have effectively branded all farmers, ranchers and outdoorsmen as ones who do not care about protecting the land, the wildlife or the heritage of respect for the environment that runs deep in the culture of rural America."


text: This my friends is what a primitive lake looks like in the Desolation Wilderness up close! We would follow this lakes rocky shores that would take us up onto a small peninsula where we would have dinner at. There are some nice views of Pyramid Peak off in the distance and like many of the lakes located here the water is crystal clear as well as pristine.


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CLAREMONT, CA. – Tuesday night did not end in the Pomona-Pitzer Women's Volleyball Team's favor as the Sagehens fell to cross-street rival No. 2 Claremont-Mudd-Scripps 3-0 (25-20, 25-17, 25-14). The Sagehens put up a tough fight in each set, but the Athenas prevailed due to their tenacious defense above the net as they recorded 14 assisted blocks and two solo blocks. Julia Zwaal led the team with 13 kills and reached 14 digs while Adrienne Tong delivered 23 assists and 10 digs.
Season Impact: With the loss, the Sagehens are now 8-12 overall and 5-3 in the SCIAC.
The Sagehens looked to give the Athenas a tough battle in the early going. Trailing 7-3, Julia Zwaal crushed a spike and followed with two straight service aces to bring the Sagehens within one. After the Athenas rallied to extend the lead 14-9, the Sagehens battled back, scoring off a CMS handling error and a kill by Isabel Kelly. However, CMS managed to pull away and a kill by Jackie Jones off a toss by Phoebe Madsen sealed the set 25-20.
The two teams battled back and forth to start the second set, but with the score tied 5-5, the Athenas pulled for the lead after scoring three straight. Behind 13-7, Pomona-Pitzer responded with a 3-0 run when an attacking error by CMS and two straight kills by Zwaal brought the deficit to 13-10. Unfortunately, CMS found more firepower and unleashed a 4-0 run to extend the lead 18-11. The Athenas never looked back to take the set 25-17.
Things looked more optimistic for the Sagehens in the third set when they broke out for the lead after trading points early in the set. Trailing 11-9, the Sagehens took advantage of an attacking error by CMS and followed with a spike from Zwaal. They took the lead after another attacking error by the Athenas. However, the Athenas' offense came to life once more, breaking out with a giant 10-0 scoring spree. They closed out the set 25-14.
Up Next: The Sagehens will host University of Redlands on Friday, October 12 at 7:00 p.m.


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Cree's quarterly results beat Wall Street forecasts
LED lighting company Cree posted quarterly results that easily exceeded analysts' expectations, but its revenue continued to decline.
Cree shares rose in after-hours trading Tuesday.
CEO Chuck Swoboda also told analysts during a conference call that the company is gearing up to produce exterior automotive lights, such as headlights, tail lights and turning signals. The Durham-based company expects to make its first LED light for the automotive market available by the end of June.
Cree has been a supplier to auto manufacturers for more than two decades – most notably, its LEDs are used to illuminate car dashboards – but up to now it hasn't made complete lighting products for the industry.
Swoboda said in an interview that LED tail lights and daytime running lights already are a small but growing part of the automotive market, and LED headlights are also starting to make inroads.
The company reported that revenue for its fiscal second quarter totaled $347 million, down 12 percent from $394 million a year ago. But revenue was ahead of the $326.3 million anticipated by analysts surveyed by Bloomberg News.
Cree suffered a sales shortfall last spring when its conversion to a new software system disrupted its customer service, and the company said at that time that rebuilding its sales would take time.
Cree sells LED light bulbs and indoor and outdoor LED lighting fixtures, as well as components other companies use in LED lights. Its LEDs also are used to illuminate mobile phones, TVs, electronic signs and other products.
Adjusted net income for the latest quarter totaled $30 million, or 30 cents per share, versus the 11 cents per share projected by analysts.
Cree announced last month that its revenue and net income would be boosted by a settlement of its patent infringement and false advertising complaints against a major competitor, Feit Electric, and its Taiwanese supplier.
"We made progress in fiscal Q2, as commercial lighting revenue increased several percent sequentially, due to increased demand across several product categories," CEO Chuck Swoboda told analysts during a conference call.
He also said that although consumer lighting revenue declined in the quarter, margins improved.
"Consumer feedback on our new LED bulbs has been positive, and our premium strategy has helped us improve profitability in this product line," he said. "While our products are priced higher than the competition, they perform better and last more than twice as long, which is the point of switching to LEDs in the first place and drives our overall brand positioning."
Cree reported its quarterly results after the markets closed Tuesday. Earlier in the day its shares closed at $27.41, down 8 cents. The shares hit their 52-week high of $32.92 last March.
David Ranii: 919-829-4877, @dranii


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CANYON - Mildred May Leavitt, 93, of Canyon died Wednesday, June 26, 2013, in Amarillo.
Graveside services will be at 10 a.m. Saturday in Dreamland Cemetery. Memorial services will follow at 11 a.m. in Brooks Chapel in Canyon with David Crump, of Calvary Baptist Church, officiating. Burial will be in Dreamland Cemetery. Arrangements are by Brooks Funeral Directors of Canyon.
Mildred was born Mildred May Scott on Feb. 17, 1920, to Owen and Jewel Scott of Wynnwood, Okla. She and her parents moved to Canyon in June 1929, where they farmed near Happy. It was there that she met the love of her life, Roy Leavitt. They married on Aug. 3, 1940. He preceded her in death on July 30, 1985. Roy and Mildred moved to Dalhart in 1946 and resided there until 1968, when they moved back to Canyon. Mildred was loved by all who knew her. She loved her Lord and was an active member of Calvary Baptist Church in Canyon until her health prevented her from attending as much as she wished. A special part of her life was the Coffee Break Bible Class and the close-knit women of that class. She would want to thank all those who were so faithful to visit her at home and in the hospital.
She also was preceded in death by a brother, Owen William Scott of Beaumont, on May 16, 2011.
Survivors include a nephew, George White and wife Linda, her caregivers, of Amarillo; two nephews, Loyd Leavitt and wife Omega of Happy and David Leavitt and wife Judy of Tulia; two great-nephews, Todd and Troy White, both of Amarillo; a great-great-nephew, Brandon White; a sister-in-law, Odessa Leavitt of Happy; and many more nieces and nephews too numerous to mention; her dear friend whom she considered the sister she never had, Arzella Kinsey of Canyon; a dear cousin, Dorothy Bird of Amarillo; and numerous friends from throughout the United States.
The family wishes to thank the staffs of Baptist St. Anthony's Hospital and Hospice and Kindred Hospital for the love and care shown to Mildred. Also, sincere thanks to Dr. Salil Trehan for his wonderful compassionate care of Mrs. Leavitt. The family will be at 14411 Suzanna St. in Amarillo for those who wish to stop by.
Visitation will be from 6 to 8 p.m. today at the funeral home.
The family suggests memorials be to assist patients at Baptist St. Anthony's Hospice, in care of Don and Sybil Harrington Cancer Foundation, 1600 Wallace Blvd., Amarillo TX 79106; or a favorite charity.
Sign the online guest book at www.brooksfuneral.com.
Amarillo Globe-News, June 28, 2013


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Merhaba friends!
Given the reality of our short existence, especially nearing 30 years old with roughly 19,000 rotations around the sun left - if we are being specific, god willing - I thought it might be a good idea to consider dedicating my time to tasks I find most fulfilling while slowly phasing out the habits that no longer serve me positively. Since I was a child, writing has been a comfort to me, something I would return to over the years on lonely nights when the world was too overwhelming to bear, so I thought keeping a travel blog as a way to chronicle my memories of the road I've tucked safe away, would nicely pair both my passion for photography and my desire to write. If not for fear of age blurring the sharper details of life's memories, I would continue to procrastinate on blogging, but I've already wasted so much of my time cowering with anxiety over what I perceived to be a big scary world. As a former agoraphobic and socially anxious introvert, life has felt like a small speck gasping for air in a universe so overwhelmingly large I could only ever dream of having the courage to explore a tiny portion of it. Through little steps every day for decades, I've been able to gain the confidence in myself enough to explore beyond my own small experience. First by simply stepping foot out the front door, then within the confines of my own continent adventuring around North America, finally culminating in my very first trip overseas. With this growing trust in myself and the full confidence in the overpowering goodness of humanity, I intend to make each new day a wonderful journey and an opportunity to learn while hopefully sharing that learned experience with all the new friends I meet.
A few years back I discovered a passion for travel and promised to do so by any reasonable means. Working to expand my mind beyond my own limited perspective while opening my heart to the excitement of new cultures and places, is worth more to me than any last dollar I have to my name. When I was offered the opportunity to join a tourism conference in beautiful ancient Istanbul, I immediately jumped at the possibility of setting off on another adventure - though my body went into the standard response of fetal position panic mode. My highly sensitive easily overwhelmed friends among us can sympathize. I was feeling especially stressed with the media harping on how unsafe the country is due to it's proximity to Syria, targeting of westerners, and the heightened threat of terrorist attacks - the same threat really as in any large city of the world and with that same necessity to remain vigilant at all times. There was not one second I felt unsafe and it was something I was quick to learn within minutes of entering the city. The people I met were warm hearted and friendly, the food absolutely spectacular, and to walk in the steps of so much of civilization made for priceless memories worth conquering every fear for.
I've found the best way to combat anxiety is through preparation - so I set out an hour a day for four months to learn as much of the culture, language, and past I could before my first journey overseas - an easy task for someone that enjoys history.
The Republic of Turkey is a marvelous country rich in the history of humanity. In the Taurus mountains of western Turkey the rivers Tigris and Euphrates gave life to the fertile crescent where man learned to farm in the dawning of the agricultural age and where humans ultimately went from wanderers and nomads, to building large extravagant civilizations. Constantinople, of what is now present day Istanbul, was the capital of the Roman Empire from 330AD - 1204AD. Emperor Constantine found the strategic location better for trade and a safer place to defend the empire. He was the first emperor to protect religious freedom, which included the persecution of followers of Christianity. He is considered to have consolidated the religion and his influence helped build the first major thriving Christian city named in his honor. Ruled by the Romans and Ottomans for thousands of years you can still find the history of each civilization woven into the fabric of this magnificient modern metropolis. Istanbul is the largest city in Europe and the cultural, as well as financial, hub of Turkey with over 15 million people residing here. It is also the only city in the world divided on two continents, Europe and Asia, with the shores of the Bosphorus and a short (and inexpensive!) ferry ride in-between. Strategically, Turkey is incredibly important wedged between the Black Sea and Mediterranean Sea of which trade routes helped facilitate it's position of wealth for thousands of years.
On my first full day exploring the ancient cobblestone streets of Old City Sultanahmet, I spent the morning wandering alone finding myself lost in a maze of hotels, shops, and museums. Admittedly very trusting and naive, I learned rather slowly that if someone stops you on the street it is 100% a trap and they are trying to take you back to their shop to sell you things while serving you endless amounts of tea. This exceptionally polite vegetarian spent three hours in a fur and leather shop after I agreed to coffee offered by a kind stranger I met near the bazaar. On principle I am against the fur and leather industry, but keeping an open heart and mind, it was interesting to learn about the importance of the export and Turkish traditional craftsmanship. Meeting this man was my first opportunity to speak some of the Turkish I've been learning and I grateful to be able to pick up a few new words. I found a majority of people in Istanbul speak English but they truly seem to appreciate those who try to learn the language. A Turkish word is usually received with a big smile. I had a wonderful conversation with my new friend about following your passions, turkish culture, and the once thriving tourist destination.
Turkey is hurting badly from a declining tourism industry. Talking with the shopkeepers and the event leaders working in the tourism field, there are estimates of the formerly booming industry dropping by 75%, which I would imagine has a lot to do with the majority muslim population and a media with a set narrative of propaganda. Although I always felt very safe with police officers securing every street corner, I found the once crowded streets of Sultanahmet to be empty of many travelers. When asked to explain my reason for visiting, shopkeepers often thanked me for helping to bring awareness to the situation in the hopes of bringing back tourists to visit the beautiful country.
After the kind stranger coffee experience, I definitely needed a nap to help the jet lag before I had my first meeting with the other influencers, but I was struggling to find my way back to the hotel. Try as I may with two maps and screenshots of directions in hand, I truly have no sense of direction - but sometimes getting lost is quite an adventure itself and an opportunity to find comfort and familiarity in the chaos. I stopped to ask directions from a man on the street and upon realizing how very lost I was, he walked me the mile back to my hotel, in the opposite direction of where I imagined the hotel to be.
For my first few days in Istanbul I had a marvelous stay at the Sura Hotel in Sultanahmet on the Amber floor. The room was spectacular with intricate gold detail work, moody ambient lighting, and complete with a balcony to sit and listen in awe (while often weeping) as the call to prayer echoed from the nearby Blue Mosque. The amazing complimentary buffet for breakfast every morning lasted three hours with so much fresh food and Turkish delicacies to keep you fueled for a long day of exploring the historic locale, all of which were within walking distance. Hagia Sophia and the surrounding sites were only a 5 minute walk down the winding streets. The service was spectacular, everyone I met was so kind and accommodating to anything I may have needed. I loved the little touches in the room of fresh fruit, nuts, and Turkish delights that made me feel so welcomed. They even have an airport pickup service that I took full advantage of as I'm easy to get lost, which took the stress completely out of my arrival in Istanbul.
There was a cocktail party with influencer dinner in the lobby of the incredible Sura hotel on my second night where I was able to finally meet with the group organizing the event, Inflow Travel, as well as the other social media influencers flown in from all over the world to experience Turkey. I find these types of trips extremely valuable as they offer a lot of opportunity to not only learn a bit about the culture of the host country, but to learn from the vast amount of worldly knowledge of the other influencers. I was thankful to meet so many new inspiring friends while dining to incredible food and live music!
The next day we ventured out across the city back to Ataturk airport for a group breakfast courtesy of Do&Co - the catering company that provides meals to Turkish Airlines, who sponsored the trip. We also suited up in clean apparel and were taken on a tour of the facilities. It was interesting to see the production lines where the food was being prepared handmade from fresh ingredients, I was certainly given a different perspective while I enjoyed my meal on the plane ride home.
Later that evening, with my new friends Alvin and Henry we parted ways with the group during our down time to make our way to the Grand Bazaar. The intricate avenues of the Grand Bazaar, one of the largest and oldest covered markets in the world with roots in 1455AD, is definitely not for the socially anxious, extremely busy with people looking to get in a little shopping in. If you need it, you can find it at the Grand Bazaar. Usually I'm not one for large groups, especially packed elbow to elbow, but with the courage of my new friends and the heavenly smells of coffee and spices, I ventured into the chaos. I truly loved and embraced this new experience.
For 100 Turkish Lira (only $29 USD!!!) I was able to purchase many souvenirs for friends with tea, coffee, and Turkish delights to last me until my return. I have never seen so many lights and products on display. As you walk along, the shop keepers will yell out phrases in many languages in the hopes people will turn their heads enough to reveal what language to use to lure you in. Shop keepers in the city can be a bit aggressive, but I found myself laughing at the clever tactics they use to bring customers in.
These days the dollar is very strong against the Lira so it's an excellent time to visit for an inexpensive trip. I budgeted 300 Turkish Lira for spending money during my 6 day stay which ended up around $89 USD. I actually had a hard time finding enough things to spend it all on, everything is so inexpensive.
The market even opened up to side streets of endless shopping, sugary goodness, and coffee! If only I had a dozen more suitcases to bring all my treats home. I returned to Maine with two extra bags and 5 extra pounds of turkish treasures.
On our last day in Istanbul, we took a guided tour of Hagia Sophia, courtesy of Fest Travel, before stopping at the Topkapi Palace for lunch. Hagia Sophia, built in 537 AD, is a testament to the ever evolving nature of the region - a structure first built by the Romans as a Christian cathedral before being converted into a mosque after the Ottoman's conquered the city bringing with them the religion of Islam. Inside it was a marvel to crane my neck to witness so many relics from the past colorfully and intricately telling tales from long ago. I even got to pet the famous cat, Gli, who has made a home in the museum and crawls willingly into any open lap that becomes available.
As an added bonus, here is a sampling of the delicious food I was able to taste while touring the city. Being a vegetarian was a bit of a challenge, visiting the founding country of the kebob, but everyone was so kind and accommodating! The buffets were my favorite with so many varieties of fruits and cheeses and a vast spread of yogurts and breads. Breakfast was always a buffet lasting hours allowing me my fair share of the local flavor. For dessert, the Turks absolutely love their sweets. I'm more of a savory gal myself, but my sweet tooth definitely got it's fill of Turkish delights and baklava.
After our tours and lunch at the palace we packed up our possessions for an afternoon flight west for the second leg of our tour. Although we weren't able to tour a few places I would have wanted, luckily I get to return in April for a fresh perspective and warmer weather!
Stay tuned for Part Two of this Turkish adventure with a stay in the cave hotels of Cappadocia, Turkey!
Thank you so much for reading. Teşekkür ederim!
Interested in the preset used to edit the photos in this post? You can find a complimentary preset here!
Although this event was sponsored and organized by Inflow Travel & Turkish Airlines, all opinions remain entirely my own based upon my own personal experience.


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Our site is responsively designed so you can always access your account and reference your information if needed on any mobile device. There are just a couple of things that may not work, primarily our drag and drop features.
There is certainly a long list of features on our development schedule for the coming year, including a mobile app! We cannot wait!


text: Schools full of smokers starting each day 5 December 2013 BHF Press Office Category: Survival and support New research has revealed that almost 600 under-16s take up smoking every day in the UK. A large-scale study has found that, amongst 11 to 15 year-olds, an estimated 463 children start smoking every day in England, 55 in Scotland, 30 in Wales and 19 in Northern Ireland. Starting smoking at a young age paves the way for serious health problems later in life. Smoking is a leading cause of cardiovascular disease, and smokers are almost twice as likely to have a heart attack compared with people who have never smoked. This is yet more evidence of the urgent need to wipe glitzy logos from cigarette packaging. Our Chief Executive, Simon Gillespie, said: "These shocking figures show that every day nearly 600 children - the equivalent of small school - start smoking in the UK. The clear lesson from this research is that we need to further our efforts to stop children becoming addicted to a lethal product. While the Government looks at whether to introduce standardised packaging, this is yet more evidence of the urgent need to wipe glitzy logos and attractive designs from cigarette packaging and help discourage children from this deadly habit." Read our policy on tobacco marketing


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Oxidised sterling silver cufflinks by Bridget Kennedy.
approx 13mm x 18mm.
The Pebbles Range was inspired by a walk along a pebble beach in Palawan, Philippines. At the end of the beach was a beautiful and cooling, freshwater waterfall, which fell into cascading waterholes, before merging with the saltwater of the ocean.
Please note, each piece is individually made and slight variations may occur.


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Ziggys Fresh is one of the oldest fruit market stores in Canberra and the longest running fruit and veg store right here at Belconnen Fresh Food Markets.
Family owned and operated since the business began, Ziggys continues to provide fresh, quality seasonal produce to market goers every week.
Ziggys is committed to providing the best customer service and if for any reason you are not completely satisfied with your purchase, Ziggys will happily replace your purchase for total satisfaction.
Please don't hesitate to contact Ziggys if you would like to enquire about bulk buying and catering options for large groups.


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In the past couple of years, the sheen has begun to come off the aid industry. Books such as Dead Aid have pointed out that aid, in general, doesn't tend to promote prosperity. Rather, it squeezes out private enterprise and so helps keep people in poverty. The aid industry also has another, much less-discussed, PR problem: its continued willingness to work with "scoundrels" despite the end of the Cold War. William Easterly has argued in a recent piece in the New York Review of Books that "the nations and organizations that donate and distribute aid do not care much about democracy and actively support dictators". He points out that dictators have received around a third of international aid expenditures since 1972. The proportion of aid received by democracies, meanwhile, has remained stuck at about one fifth.
Why? Well, there's an argument that supporting "effective" dictatorships works. Speaking on the World Service this week, best-selling author John Naisbitt mounted a robust defence of China's authoritarian "vertical democracy" (whatever the hell that is) that has "allowed China to change in 30 years from a nation of poverty and backwardness to become the third largest economy of the world". The £10 billion that has poured into increasingly authoritarian Rwanda since the genocide in 1994, meanwhile, has resulted in infrastructure that puts most other East African countries to shame.
This is, of course, a sham. There's nothing benign about any dictatorship. Easterly notes that that a new Human Rights Watch report has shown how aid money has been used by dictatorships to trample on dissent. One farmer told HRW that "[village] leaders have publicly declared that they will single out opposition members, and those identified as such will be denied…access to fertilizers, 'safety net' and even emergency aid".
But maybe that's a price worth paying? Well, that's not really true either. As Indian businessman Raghav Bahl has pointed out, the efficiency of dictatorships is generally a fiction. It takes half as much effort to create a unit of GCP in democratic India than it does in autocratic China. Or take Chicago, which was until recently a corrupt one party state (it's still very much a one party state, but corruption levels have fallen). In the 1990s, activities from union corruption to drug trafficking were uncovered in the City Hall that led to the conviction of 18 individuals.
How, then, could aid agencies change their policies to make a positive impact? It's clear that reducing, or indeed suspending, aid to dictatorships and directing it on democracies instead wouldn't be a bad start. At the moment, aid money is giving authoritarian leaders access to a revenue stream that is independent of tax returns (rather like petrol dollars). This gives them no incentive to invest in the capacity of the people that they represent. Cutting the money would provide a powerful incentive for governments to reform (or, depressingly, go cap in hand to the Chinese). In those countries where dictators cling to power, aid agencies could focus their money on local communities that have a democratic model of governance (whether that's formal or informal matters not).
That's not to say, however, that working at a more local level should only be the goal of aid agencies in the most authoritarian regimes. The LGiU would argue, and indeed this government seems to agree, that central government never really had the answers anyway. Functioning, well-organised local communities, not a powerful central state, is the vital pre-requisite for any meaningful improvement in people's health, well-being or educational attainment. Doubters are advised to consult the failure of the last government's well-intentioned, but ineffective, top down target-driven approach.
Local government is the only organisation that has the capacity, mandate and staying power to support the creation of healthy local communities. UK councils as politically diverse as Newham and Hammersmith & Fulham are succeeding in empowering residents to take their future in their own hands. Of course, aid agencies can't go around setting up levels of government in the developing world. They can, however, make local politicians their principal focus and help empower local people to hold them to account. With recent constitutional changes in Kenya that devolves power to localities, now might be the ideal time to strike.


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How do I register for a CAS Outreach online credit course?
OSU students must enroll on my.okstate.edu.
If you are not a currently enrolled OSU student, you must apply for admission before you can register for courses. Once you are accepted as an OSU student, go to the Okey page, to get your ID and create a password. After that, you can log in on my.okstate.edu and register for your online class.
How do I know I am registered for my online course?
Go to my.okstate.edu and check your schedule. We do not send emails or notify you in any other way. It is your responsibility to check this.
When will my online credit courses start and end?
All courses are concurrent with the standard OSU semester schedule unless otherwise noted. The website for the OSU Registrar lists dates and deadlines, including the deadlines for dropping a course, for the current semester.
How do I drop an online course?
After the close of the open enrollment period, you MUST notify the Registrar's office in writing to drop an online credit course.
Add and Drop actions for online course sections should be done through my.okstate.edu. Information regarding drop and add dates can be found at the Office of the Registrar.
What if I forgot to drop my online credit course until it was past the deadline?
OSU has a process you may follow. Complete a Petition to Drop a Course After the Deadline. Instructions are included. You will need to take the completed petition to your advisor as a first step. Your advisor will tell you what needs to be done next. Note: Simply forgetting the deadline is not considered an excuse. You must submit proof of extraordinary circumstances.
How much does an online credit course offered through CAS Outreach cost?
Students taking online courses at OSU are charged standard OSU tuition and fees, plus a $100/cr.hr. distance learning fee. Students who are only taking distance learning courses (no courses on campus) may not be charged some student activity fees equivalent to $30.70/cr.hr. Tuition is subject to change without notice.
How will I be billed for the course?
All courses are billed to your OSU Bursar account.
What if I get tuition waivers or have a scholarship? Will they pay for my online credit courses?
Most scholarship programs and waiver programs will pay for distance learning courses. To be sure, check with the financial aid office (405-744-6604).
If I drop a course after the final refund period, can I still get a refund?
As a general rule, NO. If you believe you have extraordinary circumstances, you may complete and file a Petition to Request a Refund After Deadline. You must submit proof of the extraordinary circumstances. Again, simply forgetting the deadline is not an acceptable reason for a refund.
What textbooks do I need?
Textbook information is detailed with the individual courses on the my.okstate.edu Self Service site. To be absolutely certain that the information and edition are correct, please check with CAS Outreach or the instructor if you are ordering books online from a commercial seller rather than using the OSU Bookstore.
Where can I get my books?
You may purchase textbooks from any bookstore or online textbook source. Feel free to go wherever you find the lowest prices. You can call the OSU Bookstore at 405-744-5237 (or 800-831-4698) and request books to be shipped to you. MUSI 2573, POLS 1113, SPAN 1115 and SPAN 1225 require purchase of an access code in addition to your text, or in place of a text. You may purchase it at the OSU bookstore, or directly from the publisher. Information about that is available at the textbooks links above.
If my course requires a proctor/testing center for exams, how do I find one?
First, you may not need a proctor. Please check the course syllabus.
Non-proctored or take-home exams are permitted at the discretion of the instructor. Non-proctored exams enable students to take the exam at a location and time of their convenience within the bounds of a specific postmark date or other specified time frame. Students are expected to conduct themselves in accordance with the Academic Integrity policy described in the University catalog.
Plan to take the exam during the time frame designated by the instructor. This time frame will be announced in the class materials.
The exam must be completed and submitted per instructor's instructions. Example: placed in the D2L dropbox, faxed, etc.
Proctored Exams
If you need a proctor or testing center, you MUST complete a Proctor Agreement Form and return it to our office. To determine who is qualified to act as a proctor, please read the Proctor Qualifications.
For courses requiring a testing center, you may use the University Assessment and Testing Office in the UAT Building at 1524 W. Admiral (charge is $20/exam). Call 405-744-6390 4-5 days before the exam to schedule an appointment or schedule online. The fee will be charged to your Bursar account. Off-campus students may use a testing center at any nearby college, university, community college or vocational-technical school. Fees vary from school to school. Feel free to find the center with the lowest fee in your area. Ask a representative at the testing center to complete the Proctor Agreement for you and return it to our office.
Due to limited availability of certified testing facilities, paper based exams are unable to be administered to students located internationally. Students should verify exam method in a course prior to enrolling, if international travel is required. Students located internationally during exam period(s) for an online administered exam (Brightspace) are required to use ProctorU or ProctorTrack, an online testing service. Students may contact the Outreach office before enrolling to determine if the course will require proctored paper exams. Co-workers, associates, friends, other students, family members and neighbors are not acceptable proctors, regardless of their education or corporate positions.
ProctorU is available to use as a proctor in addition to the option of going to a testing center. It is available only for exams that are administered online through D2L. ProctorU is a live online proctoring service that allows exam takers to complete their exams at home while still ensuring the integrity of the exam. Using almost any webcam and computer, you can take exams at home, at work, or anywhere you have internet access. To get a better understanding, watch the How It Works video. Check if your computer and internet connection meet all of the technical requirements to use ProctorU.
ProctorTrack could possibly be an option (check with your instructor). It is also available only for exams that are administered online through D2L. ProctorTrack is an automated remote proctoring solution.
All associated charges will be the responsibility of the student.
The completed Proctor Agreement form may be:
• Faxed to 405-744-6992
• Scanned and emailed to email@example.com.
• Mailed to A&S Outreach, 213 LSE, Stillwater OK 74078 (allow 10 working days to assure delivery)
If you have further questions about our policies or need help locating a suitable proctor please contact the Outreach Office at 405-744-5647 or email@example.com
How do I log in to my online credit course?
To log into Canvas courses, go to canvas.okstate.edu. Use your Okey ID and password to log in. If you are uncertain of your Okey ID or password, call the helpdesk at 405-744-4357. Or email email@example.com. It is important to turn on notifications within Canvas (instructions on ITLE's website) and to call 1 (855) 691-6198 with any questions 24/7.
213 Life Sciences East
Oklahoma State University
Stillwater, Oklahoma 74078


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The EndoCinch endoluminal gastroplication surgery used to be a treatment option for gastroeophageal reflux disease (GERD). However, due to disappointing long-term success rates, this surgery is no longer used.
Today, other treatment options are available. These include prescription and over-the-counter (OTC) drugs along with surgical and nonsurgical procedures.
Gastroesophageal reflux disease (GERD) is the chronic form of acid reflux. This condition occurs when the contents of the stomach, including stomach acid, leak back into the esophagus.
Normally, stomach contents are kept in the stomach by a group of muscles called the lower esophageal sphincter (LES). When these muscles aren't functioning properly, digestive juices and stomach content can move back up into the esophagus.
When muscles in the LES aren't functioning properly and digestive juices and stomach acid move back up into the esophagus it may cause symptoms that include:
- burning sensation in the chest, or heartburn
- regurgitation
- sore throat
- sensation of a lump in the throat
- difficulty swallowing
- feeling of excessive fullness
Over time, GERD can damage the lining of the esophagus and lead to serious complications that include:
- severe chest pain
- narrowing of the esophagus
- bleeding in the esophagus
People with GERD will need continuous, long-term treatment. There are prescription and OTC drugs available.
Prescription medication, like proton-pump inhibitors (PPIs) and H-2 blockers include:
- dexlansoprazole (Dexilant, Kapidex)
- pantoprazole sodium (Protonix)
- lansoprazole (Prevacid)
OTC medications include:
- esomeprazole magnesium (Nexium)
- omeprazole (Prilosec)
- lansoprazole (Prevacid)
- cimetidine (Tagamet)
- famotidine (Pepcid)
- ranitidine (Zantac)
Also, Barrett's esophagus, a serious complication linked to an increased risk of esophageal cancer is usually treated with OTC antacids. If these don't work, your doctor may recommend other medications or surgery to help strengthen the LES.
Most people with GERD don't have fully functional LES muscles. Surgical and nonsurgical procedures are used to help strengthen or reinforce these muscles.
A surgery known as EndoCinch endoluminal gastroplication (ELGP) was a treatment option for GERD. ELGP was an outpatient procedure considered minimally invasive because it didn't require any incisions into the abdomen.
ELGP combined endoscopy with a suturing, or stitch, system to reinforce the LES. An experienced endoscopist typically performed this procedure.
The procedure
ELGP was performed under sedation and took less than two hours. It involved the following steps:
- An endoscopist inserted a tube down the throat to the muscles that connect the throat to the stomach.
- Using an endoscope, the endoscopist examined the inside of the esophagus and confirmed earlier findings.
- The esophagus was dilated, or expanded.
- The doctor used suction to capture a fold of tissue of the stomach.
- Using the EndoCinch device, which resembled a miniature sewing machine, the doctor stitched the fold of tissue just below the LES. Most people required two or more stitches to strengthen the LES and prevent backup of stomach acids into the esophagus.
- The device and tube were removed.
Most people who had this procedure returned home the same day and were able to resume normal activities within 24 hours.
Long-term outcomes
EndoCinch was thought to be a good option for people who don't respond well to drugs or aren't good candidates for Nissen fundoplication or other surgeries.
However, the
There are now other treatments for GERD that are considered more effective than the EndoCinch procedure. These include:
Nissen fundoplication
Today the standard surgery to treat GERD is called Nissen fundoplication. This is a laparoscopic procedure that involves making three or four small incisions in the stomach. Surgical instruments are inserted through the incisions, including a flexible tube with a small camera. Once the surgeon is able to see the area they will strengthen the LES by wrapping the upper stomach around it.
Stretta procedure
The Stretta procedure involves inserting a tube down the throat and inflating a balloon to the size of the patient's LES. Radio waves are then sent down the tube to provide a tightening effect to the LES. The tube also releases water to help prevent any heat damage inside the body.
The procedure takes about 60 minutes and requires sedation.
LINX reflux management system
The FDA approved LINX in March 2012 as a device for the treatment for GERD. It is a permanent implant that consists of a small, flexible band of beads. Each bead contains a magnet.
The band is placed around the outside of the esophagus. The magnetic attraction of the beads keeps the sphincter closed to prevent stomach contents from moving back into the esophagus. The beads temporarily separate when swallowing to allow food to pass through normally.


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A report from last week claimed Iran had 'joined' the Entertainment Software Rating Board. The ESRB, meanwhile, has no idea where that came from.
"We have not had any discussions with Iran about adopting our rating system," said Eliot Mizrachi, Assistant Director, Communications at the ESRB.
More questions were raised, however, when a second report released this morning detailed the symbols to be used for the Iranian ESRB program. The symbols were revealed as part of a ceremony held this past Saturday in Tehran.
"If we think a bit, we will find out that the major goal of computer games is to create heroes. And we can revive the culture of Persian championship with all its Iranian and Islamic elements through national computer games," said Mohammadreza Jafari-Jelveh, Iranian Deputy Culture Minister for Cinematic Affairs during the opening ceremony.
It should be noted that in the picture above, it clearly says ESRA, not ESRB. However, the two reports specifically stated this program was in conjunction with the Entertainment Software Rating Board.
ESRB symbols unveiled in Tehran (Tehran Times)


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Frequently Asked Questions (FAQs) on Drug-Medical Device Combination Products
Five (5) years, in line with product registration validity.
Yes, the endorsement letter issued by the NPRA will be valid from the date of issue until 5 years from product registration approval date.
Yes, endorsement letter is required. However, case-to-case basis can be considered if the performance of ancillary medical device is not affected by the drug component.
No. It is advised to list all the drug-medical device products which contain the same ancillary medical device, in one application form for endorsement letter of ancillary component.
It is not required for medical device-drug combination product registration, where the combination is packaged together in a single package, provided that the ancillary drug component is essentially the same as the registered product with a valid registration status with Drug Control Authority.
However, for medical device-drug combination product produced as a single entity, the endorsement letter is required. Example: An endorsement letter of ancillary paclitaxel is required for registration of coronary drug-coated balloon catheter, although the paclitaxel used has a valid registration status with Drug Control Authority for parenteral use.
Yes, it is required for both API and active biological substance
Fill in the application form for endorsement letter of ancillary component with check list of the relevant drug category (New Drug Product, Biologic, Generic) and submit manually to Centre for Product Registration, National Pharmaceutical Regulatory Agency.
You may apply for classification application or refer to definition of each category at available at here.
Endorsement letter of ancillary medical device component can be uploaded at part Product Validation item 18 of Quest 3+ system during product registration application.


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Khaab Khayaal Saraab
Working Area for http://iFaqeer.blogspot.com/ and http://WadiWallah.blogspot.com
ithnee qismath, aisee qismath pyaaray kis koe milthee hai
kay maanga khaab khayaal saraab aur paaya khaab khayaal saraab
-- Kashif Yaqoob
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Thursday, April 01, 2004The dreams of our elders:
Listening to America
Alternative MediaWhat The Other America is thinking and talking about:
Democracy Now!
with Amy Goodman
Your Call Radio
with Laura Flanders and Farai Chideya
Major Public Radio ShowsWhat thinking American is ... thinking about.
NPR News with Tony Cox
National/Coloured America (See this.)
The Brian Lehrer Show
New York
The Connection (Dick Gordon)
Forum (Michael Krasny)
San Francisco
C-SPANC-SPAN provides firsthand, unedited view of what four or five of the modern "Estates" of the establishment is talking about.
Listening to Dem Po' FolkAzad South Asia
Parent of This Blog
banaa kar faqeeron ka hum bhais, Ghalib...My "official" blog
Life, technology and getting by in Silicon Valley
Spider.tm blog
The View from Pakistan(i IT)
The Id of South Asia Urdu ke Naam
A collaborative blog dedicated to the language of Urdu


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Land Registries » Halton Land Registry (NO.20)
Halton Land Registry (NO.20) Land Registry Office
Contact Information
Halton Land Registry (NO.20)
2800 Highpoint Drive, 2nd floor
Phone: 905-864-3500
Fax: 905-864-3549
Title Searchers / Registry Agents that work out of this office:
40+ yrs title searching (residential & commercial) exp. for Ont. law firms, appraisers, surveyors, banks, individuals. Worked for Ministry of Government Services, Realty Services Branch, as Title Search Technician out of Queens Park Toronto. E&O INS
|Maria Title Searching Services
30+ years of experience. Quick, accurate detailed searches available at reasonable rates. E-mail and on-line searching is also available. Public Welcome - Paypal accepted.
|Monica Mitchell
40 years experience. RELIABLE, ACCURATE,INSURED. FULL SERVICE OFFICE: Titlesearching/Conveyancing./EReg/ Court Filings.
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Accurate and reliable Title Searcher, providing detailed and comprehensive searches, completed in a timely fashion. Serving the Legal Profession for 30 years. Fully Covered by Professional Liability Insurance
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Speedy Search and Registry is a leading Title Search Company providing fast affordable title searches across Canada. Property titles are emailed to you within minutes of your order.
CONTACT email@example.com for "METES & BOUNDS" SPECIALIST: INSURED & ACCURATE; FAST; DEPENDABLE; LONGTIME LOCAL MILTON "IN HOUSE" RESIDENT; OVER 35 YRS. EXPERIENCE!
|SUSAN LESTON / Leston Paralegal Services Limited
ACCURATE,DETAILED,RELIABLE. 35 years experience.Searches are detailed and easy to read.Environmental searches, problem solving. Fully insured, member of The Law Society of Upper Canada
|Lisa Leva Title Searching and Conveyancing
ACCURATE, RELIABLE, PROFESSIONAL Title Searcher with over 20 years experience. Providing a high quality standard of service for your real property search and registration needs at 7 LRO's. OAPSAR member, insured, references on request.
Are you a title searcher / registry agent that works out of this office? Click here to advertise with us.
More Information:Halton Municipalities
City of Burlington
Town of Halton Hills
Town of Milton
Town of Oakville


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Pyramids of life (Blouse)
" She gave no thoughts about naysayers. She considered glass ceilings as nothing but fiction. For her, power was the air she breathed. Her glow came not from any temporary feeling but from her undying confidence in herself. She had her eyes firmly set and what she desired was not money, not success. What she desired was to make the biggest difference – a positive difference through which she could touch lives like never before. She had built a pyramid of dreams, and as she conquered it one step at a time, she conquered her own pyramid of life as well!!â€
Description : This gorgeously simple blouse with pops of brightness at the neck is one that will go well with many beautiful sarees. Art does not have to be something that we admire from a distance. Especially in our culturally rich country, art has a place in most of the things that surround us and the clothes that we wear are the perfect platforms to showcase our very own identity through art. Indian art forms certainly have enough art forms that you can choose from to tell the world who you are. Among the best of such art forms is the art of embroidery. The art primarily involves making patterns on fabric by sewing using a needle and various types of threads or beads. Although embroidery has been a part of various cultures across the world, Indian embroidery has always been regarded to be very intricate and exquisite. Our country's history has shaped the development of embroidery. The art of embroidery is so evolved in our country that almost every state has its own special kind of embroidery today. Although the British rule did cause a setback to handicrafts in India, the resurrection of embroidery after Independence has been remarkable. Intricate embroidery from India is valued world over. Embroidery work on sarees and blouses is very popular and involves a process that consists of various stages. First, various types of popular Indian motifs and artistic designs are first created on paper. These designs are then traced onto the fabric and then the embroidery is done by expert artisans. The art of embroidery is passed down from generation to generation and the nuances of hand embroidery can hardly be matched by machines. Creating art on the canvas of fabrics is definitely something that has an innate beauty that adds a lot of value to apparel
- Dry clean


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Our Young generation, I am also including people who are in their mid 30s, is very cautions and most of the time certain about what they want to do and what they want to be. Some of them achieve very well, Kudos to those. Well, we all know the dictionary meaning and Wikipedia explanation of the word 'Work'. But what…Continue Reading→
Month: January 2016
Quite Messed up
One question always crossed my mind, Is it us who twist the cube or the cube twists us? 0Continue Reading→
Odd-Even review- Kudos to Arvind Kejriwal
Today was the litmus test of Odd-Even formula because people are back to work after new year celebration. In the morning, I saw some odd number cars many with CNG sticker but few were without that also. If consider that as exception, roads were comparatively less crowded. I saw some metro pictures on facebook where people were trying to show…Continue Reading→


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Our Motto will always be: "Do not take what you do not like to eat."
The Long Way to backpacking bliss……I learned how to not eat the hard way, which also seemed to involve carrying a rather large (and quaint) backpack, back in the day:
Like most backpackers, when I got into backpacking, I thought that eating freeze dried meals was the only way to go – they were light weight, they packed OK in the sense that one could grab a couple packages for a trip and be done, and were easy to make. Except for being very pricey, having little flavor and making one's stomach not feel so good. I started dreading dinner time – for some reason all the dinners started tasting the same. And cost wise, freeze dried was too expensive as I went out more often and was taking my son along with me.
So….I started cooking on the trail. And that was even worse! I hated having to carry multiple pans and then cleaning those pans, using so much fuel up to cook on windy nights. Spending an hour in the evening cooking and cleaning when I was tired was not fun. I also had become tied down to campsites that had an adequate water supply – so I could do dishes.
One day, about long many years ago, I saw mention of freezer bag cooking and I wondered how that would work for me – and for the most part I have never looked back. It is the best of both ways of cooking – it is fast, it can taste very good, you can have so much variety and it is affordable. The food is very packable – and can be a way to lighten your pack weight.
Best of all, it has made it so I can have what I want for dinner, and my sons can have what they like, and we eat at the same time. It simplified my outdoor life so that I can spend more time being out there. The amount of gear I carry for my kitchen is a shadow of what I used to carry.
In fall 2004, a hiking partner and I got to talking and realized we needed to broaden our food & meals on the trail, and come up with more recipes…and make them as gourmet as we could. At the time, if you did FBC, it was usually standards like mashed potatoes and stuffing. So, we started coming up with new recipes for our weekly hikes-and trail testing every one of them in the wilds. The rules were a stove, a tea kettle or small pot, a freezer bag with the food and a spoon. The recipes came fast. We opened our eyes and saw how many products could be used.
The Freezer Bag Cooking website evolved out of this in late 2004, and in late 2005 Kirk and I published the first version of our first cookbook, Freezer Bag Cooking: Trail Food Made Simple.
As the years have passed by and we got further into it, http://www.trailcooking.com was born. We realized that while we preferred FBC, that we could do even more on the trail – be it FBC meals, FBC hybrid meals, The Fauxbaker for making baked treats and gourmet one pot meals that didn't suck up fuel or require long cleanups. We invented the soft, ultra light freezer bag cozy and opened up our gear store online.
We hope you enjoy our blog and visit our websites for more information. See our "In The News" section for articles, magazines and books we have been featured in.
Kirk and I with our two youngest sons in summer of 2016:
Contact Info/Questions? Thoughts? Ideas?
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Nutritional Information:
All information on the website and in our books is our personal writing. We are not nutritionists nor are we professional chefs. In the past we have been asked about whether we would provide nutrition counts on recipes. For now we are not doing it as the software is not reliable in providing correct amounts. There are a number of free resources to determine calorie counts online if one wants to try it. Periodically when the stats are easy to run we do add them to a recipe – if Sarah has the time to add it.
On subjects such as low sodium diets and food allergies, we are presenting what has worked for us personally. As always, if you have dietary and health concerns, talk to your doctor first.
While no one we know has had any bad occurrences on the trail using freezer bags (ie. leakers, blowouts, etc) there is a small chance of it occurring. So make sure you pay attention, set the freezer bag in front of you as you pour the water, be careful when pouring the boiling water and don't do it in your lap.
Use common sense in cooking in the outdoors, just like you would at home. All sports run injury risks, and cooking has a multitude of chances of hurting yourself (hot stoves, water, knives, etc).
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A couple months back, I got the most awesome skein of handspun from inle_rah in a swap.
I promised myself I would use it strictly to knit stuff for myself, because I usually end up neglected
So far, I've knit an Urchin and a pair of Fetching from it, and I am wondering what to do with the little bit that's left over.
So here they are:
This is the original skein, by the way. Every inch of this yarn is just riveting.