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The NCVPS Super Student Award is for students who have gone above and beyond the course requirements and as a result have enriched the content, class dynamic, their own learning, their classmates' learning, and even their teacher's learning.
Meet Nicholas
"My experience with NCVPS has been wonderful. It allowed me to work at my own pace and get help if I needed it easily. Taking courses through NCVPS has advanced my education because it allowed me to take the same advanced courses that I would take at a public school without actually going to one." –Nicholas H.
"Nicholas was one of my star students for Fall. As a homebound student dealing with health issues, Nicholas could have put school last or done much less and it would have been understandable. Instead, even though he had to work around treatments in which he would fall behind and then have to catch up, Nicholas still managed to complete everything in the course, on time, with a 96! He was always pleasant and positive, and did amazing work!" –Susan Hudgins, NCVPS Honors English Instructor
Advice for Online Students
My advice to other students would be to not get stressed out if you do not understand something. The teachers in NCVPS are very helpful, and you can also get great help through the peer tutoring center.
The Internet
One of my favorite internet sites is Youtube where I watch daily vloggers who film their everyday lives. Roman Atwood is a very interesting YouTuber who will raise your spirits and always reminds you to smile.
Gadgets and Things
I have always been very into technology and love Apple products such as Macbooks, iPhones, iPads, and Apple Watches.
The Future Nicholas
My future plans in the next ten years are to have successfully finished college and to start a career in finance or medicine. I would also like to travel more.
Random Nicholas
I have a 200-gallon tank with beautiful and colorful African Cichlids.
Favorite Book
One of my favorite books is 1984 by George Orwell. I prefer ebooks because it easily saves your page where a bookmark may fall out of a regular book.
Favorite Music
Shape of You by Ed Sheeran.
Favorite Show
Hawaii 5-0.
Favorite Travels
My family on my Dad's side is originally from Germany so we visit every so often and it is very fun.
Nicholas' Goals
My goals this year is to get good grades as I did last semester and to impress my teachers by working very hard to complete all assignments.
Nicholas' Work


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Сайт поиска работы №1 в Украине
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Satisfied employees & satisfied customers. That's what we believe in. This means not only that the primary conditions of working at E-sites are good. We also try to facilitate and invest in what you find is important as an employee.
E-sites has an entrepreneurial work culture. You will get the opportunity to cooperate with our Dutch team in a way that you can get the best out of yourself. We offer a professional working environment. We like to give you a lot of freedom, confidence and responsibility, so that we will experience your strengths. With plenty of relaxation and cosiness we promise you that you have a great time at E-sites.
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subset: commoncrawl


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Last fall, the AT&T Performing Arts Center opened in the 19-block Dallas Arts District—the largest urban arts and design district in the US. The $354 million Center was funded by a boom of philanthropic dollars, with a record 133 donations of $1 million and more, and its completion represents the culmination of a 30-year vision set forth by the city to create a globally plugged-in metropolis with a cultural milieu on par with the best in the country.
For corporate groups, this pumped up interest in art and design sweeping through Dallas is delivering a new sense of international style and all sorts of sophisticated venues.
The new facilities at the Performing Arts Center include the glass-wrapped Winspear Opera House, seating up to 2,300, the über modernist Dee & Charles Wyly Theater seating 600, and the Nasher Sculpture Garden. They were designed by architects Sir Norman Foster, Rem Koolhaas and Renzo Piano, respectively. In case you're not familiar with those names, they represent the absolute cream of the architecture world, where their buildings are considered art as much as what goes on inside.
The Arts District is located within minutes of the Dallas Convention Center and downtown business hotels.
"What's really amazing is that the AT&T Performing Arts Center is the most significant new performing arts complex to be built since New York's Lincoln Center," says Phillip Jones, president/CEO of the Dallas CVB. "The acoustics of the Opera House alone are amazing—everything that's been built is very state-of-the-art. These new facilities are great venues for groups."
The local DMCs concur, con brio.
"With all these new facilities, we're seeing more versatility than ever as a DMC," says Kaye Burkhardt, president of Dallas Fan Fares DMC. "We can obtain tickets for small groups or buy out a facility for massive conventions. What's so nice is that there are so many different options depending on a group's taste—opera, symphony, museums, outdoor sculptures. We really do have something for everyone."
Beverly Brin, GM of Ultimate Ventures DMC, says of the Opera House, "It's very classy, upscale and modern. The entire complex is just beautiful. The Winspear lobby has huge glass windows that roll up like a garage door extending the lobby into the park, which makes it a very unique space for groups. Even just the inside makes a great reception for 1,000 people."
Brin adds that the Wyly Theater has a rooftop terrace that's completely open and can accommodate 200 people for a reception or 120 for a sit-down. "The views of the city and park below are amazing."
Bitsy Burns-Matthes is director of operations for Southwest Veterinary Symposium, who has planned several trips to Dallas and Fort Worth over the last few years.
"One of many highlights was the King Tut exhibit at the Dallas Museum of Art in October of 2008. We took 60 people and they loved it—the museum always has great exhibits," she says. At the time, the traveling exhibit brought about one million visitors to Dallas before making two other US stops. It's now permanently installed in Cairo. "The fact that Dallas is able to attract the very top art collections in the world really says something about the city's art scene."
Burns-Matthes also brought her group to the Texas State Fair last fall and ran shuttle services back and forth to the hotels. Close to downtown and near the Cotton Bowl, Fair Park is a National Historic Landmark with the largest collection of 1930s Art Deco buildings in the United States. It has nearly 300 acres of park space and eight museums.
"It's great because people are on their own, they can do their own thing and there's plenty to do there," she explains. Popular spots for groups include the African American Museum, with the largest collection of African American folk art in the country, and the Women's Museum, which serves as the nation's only comprehensive women's history museum.
Kaye Burkhardt says, "In the middle of a bad economy, Dallas has opened great restaurants and a wonderful arts district; the city is open for business and our future is bright. Dallas is like Grandma's house, it has always been a staple but now it's been refreshed and renovated and it feels brand new and wonderful. This past summer we had 31 buses do a dinearound at 31 venues in Dallas—it was great! There's really so much diversity that it was hard to narrow down the choices."
She especially recommends Victory Park, just northwest of downtown, for her more cosmopolitan groups. "This is a new, trendy area of Dallas with hip restaurants, boutiques and shopping. One of the things we do in this area is buy out an art gallery for the evening and have a wine and cheese reception. It's a great way to combine art, food and business." She adds, "The Ghostbar in the W Dallas – Victory is a great place to go for a drink—it always draws a good crowd."
Beverly Brin brings groups together at Trece Mexican Kitchen & Tequila Lounge. Located in the trendy Knox-Henderson neighborhood minutes north of downtown, Trece has become the place locals go to see and be seen. The restaurant serves up old favorites and new specialties born of a love for Mexican cuisine and tequila. The VIP Wine Room seats 20; buyouts can host up to 350.
"One of the more unique things we do for smaller groups, about 20-30 people," says Burkhardt, "is have a popular local chef like Kent Rathbun give a cooking demonstration and then serve dinner right in his own home. It's always a success—a very intimate and casual experience that stays with the group."
Brin is all over that too. She says, "Kent Rathbun's restaurant Abacus is close to downtown and is great for groups of 40-45 in the private room."
Wolfgang Puck Catering's new restaurant Five Sixty is also getting gobs of buzz. Burkhardt says, "The restaurant is recognizable because it's from the opening scene of the TV show Dallas—it's a landmark on the skyline." The restaurant is located atop Reunion Tower and has floor-to-ceiling glass windows offering 360° views of Dallas. Brin notes that the modern American/Asian restaurant can fit about 100 for a buyout.
Brin says Puck also caters events held at Union Station, which was originally a grand railroad station built in 1916. "It's been completely refurbished and can accommodate about 1,000 people for receptions with food stations. It's a great place with lounges, bars and incredible balcony with amazing views of the city." Union Station is connected to the 1,122-room, 4-diamond Hyatt Regency Dallas.
Part of Starwood Hotels' Luxury Collection, The Joule, Dallas ushered in the designer streak in downtown Dallas in June 2008. The 129-room property is part contemporary art museum/part biz hotel, with a Charlie Palmer restaurant to seal the deal.
"We're booking two corporate groups there," notes Burkhardt. "This hotel used to be a bank and it's been renovated to create a trendy new accommodation…. There's a rooftop pool that jets out over Main Street. It hangs out over the building and while you're swimming you can see the hustle and bustle on the street below." Meeting capacity is 2,300 sf.
The 152-room Hotel ZaZa Dallas in Uptown Dallas north of downtown, features 4,000 sf of function space, and "attracts Hollywood stars and chic and sophisticated travelers. It's very distinct—the lobby has a bed in it," says Burkhardt. "A big draw is the Dragonfly restaurant, it's popular with both guests and locals." Indoor/outdoor space is 5,800 sf.
Another design darling of Dallas, The Stoneleigh Hotel & Spa is a historic Art Deco-era beauty also located in Uptown. The 170-room property wrapped a $38 million renovation this year and the result is a stunner. Lots of crimson and oodles of chrome and new vintage-style design pieces make the rooms feel like a Fred & Ginger Hollywood set. We love Bolla Bar's plush pink banquette rising to the ceiling. Group space is 6,000 sf.
The 1,606-room Hilton Anatole is situated just outside downtown with 342,000 sf of group space. This place is full of surprises. Besides the big gymnasium, there's a gorgeous mix of sculpture including 17th century Buddhas, life-size elephants and jade horses in the "Art Collection of Hilton Anatole." Love the cheeky new Gossip Bar and the 27th floor Nana restaurant for power dinners with its sweeping "Master of the Universe" views.
And in December, the 1,840-room Sheraton Dallas Hotel reopened next to the Arts District after a comprehensive $90 million renovation. There are 220 suites, over 230,000 sf of meeting space and the much heralded Link@Sheraton lobby biz lounge. For sport fans, the new high-tech $3.5-million Draft Media Sports Lounge features 21 flat screens and international draft brews. Stay tuned for our "On Location" story later this year.


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The gangland murder of this seemingly blameless Assistant State's Attorney outraged the public and generated criticism of law enforcement and the notorious gangs fighting in the Beer Wars (Illinois Crime Survey p.825-841). The case signified to the public and the press the inability of the courts and prosecutors to control the violence generated by organized crime, as rival factions sought to control the illegal supply of alcohol and other activities.
The results of the investigations into organized gambling are described in detail in The 1929 Illinois Crime Survey. The Report exposed the enormous profits and corruption of the police and other government officials. The Chief of Police himself, Charles C. Healey, was tried and a number of other high profile investigations took place as result of this investigative report.
The Beers Wars were a particularly violent series of killings in connection with the rivalry between gangs (Illinois Crime Survey p.921-931). Bombings and the terrorism of organized crime did not start with the Beer Wars, however (Illinois Crime Survey p.933-975).
Part III of the 1929 Illinois Crime Survey, is a detailed account of the history of organized crime in Chicago and an analysis of several aspects of the industry and its economic hold on the city (JCLC p.493-496).
Al Capone was not the first, or even the most powerful, organized crime boss in Chicago. Mont Tennes established his enormously profitable empire of gambling rings after the turn of the century. Tennes and some of his cohorts were prosecuted but not convicted. Tennes was followed by other organized crime figures, including Al Capone a relative latecomer (Illinois Crime Survey p.907-919 and Illinois Crime Survey p.977-997).
The association between organized crime and the police, the state prosecutors, and the courts was a frequent source of investigation, with some periods being characterized by more corruption than others (Illinois Crime Survey p.999-1021).
The culture of gangs and the symbolism associated with their control of political and economic institutions is analyzed and detailed in the 1929 Illinois Crime Survey (Illinois Crime Survey p.1023-1087).


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- La Compagnie des Ballets de Monte Carlo
- Monaco Dance Forum
- Académie Princesse Grace
- Season 2019-2020
- Never scene
- Group
Artistic staff
Artistic staff
Principal Ballet Master
Bernice Coppieters
Belgium, born in Termonde, on November 16th, 1970.
1980 Bernice Coppieters studied dance at the Antwerp Institute of Ballet.
1988 She joined the Juilliard School of New York winning the Prix de Lausanne in the same year.
1988 She entered the Royal Ballet of Flanders where she was made soloist.
1991-2012 She joined The Ballets de Monte-Carlo directed by Jean-Christophe Maillot. The meeting marked the start of an partnership that has lasted for over 20 years. Bernice Coppieters has inspired Jean-Christophe Maillot to create his most memorable characters in ballets: Juliet in Romeo and Juliet, the Fairy Godmother and Wicked Stepmother Cinderella, Meier in the Drosselmeier couple in Casse-noisette Circus, Beauty in La Belle, Titania in Le Songe, Death in Faust, Princess Sheherazade in Sheherazade, Her Majesty the Night in LAC.
She has also performed major roles in the ballets Concert d'anges, Dov'è la Luna, Duo d'anges, Home, Sweet Home, Thème et Quatre Variations, Ubuhuha, Vers un pays Sage, In Volo, l'Île, Opus 40, OEil pour oeil, Entrelacs, D'une rive à l'autre, Altro Canto I et II, Fauves (with Gil Roman), Men's Dance for Women, Daphnis et Chloé. Bernice Coppieters has also danced the lead roles in Sheherazade, Les Sylphides, The Firebird, Petrouchka, L'Après-midi d'un Faune as well as the repertoire of George Balanchine (Agon, The four Temperaments, The prodigal Son, La Valse, Serenade, Violin Concerto, Who cares ?, Theme and Variations). She has also worked with many modern choreographers whose pieces have become part of the repertoire of the Ballets de Monte-Carlo, or who, as guest choreographers, have created roles for her: Duende by Nacho Duato, In the Middle... Somewhat Elevated, Approximate Sonata, The Vile Parody of Address and The Second Detail by William Forsythe, Watching Waters by Renato Zanella, Return to a Strange Land, Bella Figura, Sechs Tänze, No More Play and Silent Cries by Jiří Kylián, and pieces by Karole Armitage, Lucinda Childs (The Chairman Dances), Twyla Tharp, Kevin O'Day, Angelin Preljocaj, Uwe Sholz, Jacopo Godani, Sidi Larbi Cherkaoui (In memoriam, Mea Culpa), Johan Inger, Alonzo King, Marco Goecke, and Maurice Béjart who gave her the honour of dancing his Boléro.
In recent years, she has worked for Jean-Christophe Maillot on several of his major productions for large companies such as the Royal Swedish Ballet, the Essen Ballet, the Vienna State Opera Ballet, the Korea National Ballet, the Pacific Northwest Ballet, the National Theatre of Prague, the Atlanta Ballet Company.
2015 Bernice Coppieters is Principal Ballet Master.
Ballet Mistress
Giovanna LORENZONI
Giovanna Lorenzoni is a graduate of the Rome Academy of Dance, and winner of the 1st prize in the "Nati per la Danza" and Positano Prize.
She joined the London Festival Ballet (now the English National Ballet) in 1983. During her five years these she acquired an extensive experience of the classical repertoire and danced numerous major rôles, including, The Prayer in Coppelia, with Rudolph Nureyev. She also danced the repertoires of the Ballets Russes, Balanchine, Roland Petit, Christopher Bruce and Michaël Clark. After a brief period with the Europa Ballet where she worked with Maurice Béjart, Jorge Donn and Kevin Haigen, she was engaged by the Ballets de Monte-Carlo where she further extended her experience of the Ballets Russes, Balanchine and Jiri Kylian… (she danced La Nuit transfigurée for example) as well as working with numerous guest choreographers. She has been working as artistic assistant to Jean-Christophe Maillot since 1995 with Theme and Four Variations, Home Sweet Home, Dov'è la Luna, Ubuhuha et Concert d'Anges, Vers un Pays Sage, Romeo and Juliet, In Volo, Recto Verso, l'Ile, Cinderella, Opus 40 and Entrelacs, pieces which she restaged for other companies.
Ballet Master
Asier URIAGEREKA
Spanish. Born in 1975, he studied ballet in Bilbao and then at the Royal Ballet School after having been arwarded the Prix de Lausanne in 1993.
From 1994 to 1999, he danced as a Principal dancer at the Birmingham Royal Ballet.
In 2001, he joined les Ballets de Monte-Carlo where he has danced major roles in Jean-Christophe Maillot's productions such as Romeo and Tybalt in Romeo and Juliet, the Prince in Cinderella and La Belle, Adam in Œil pour Œil, Faust in Faust, Demetrious et Oberon in Songe. He also danced in Opus 40, Dov'è la Luna, Men's Dance, Les Noces, D'une Rive à l'Autre, Altro Canto, Shéhérazade, Choré, LAC.
He also worked with choreographers : Jiri Kylian, William Forsythe, Sidi Larbi Cherkaoui, Marie Chouinard, Emio Greco, Twyla Tharp, Giacopo Godani, Johan Inger, Lightfoot & Leon, Nacho Duato, Shen Wei, Nicolo Fonte, Jeroën Verbruggen…
In 2014, he re-staged Romeo and Juliet by Jean-Christophe Maillot for the Atlanta Ballet and in 2015 for the Nothern Ballet.
In 2014, he obtained the diploma of Pilates Instructor Training. He is currently Pilates teacher at the Princess Grace Academy. And he is répétiteur at Les Ballets de Monte-Carlo.
Gaëtan MORLOTTI
1976 Gaëtan Morlotti studies dance in Ajaccio with Patricia Portal-Gozzi. In 1980 he continues the training in Paris with Solange Golovine et Félix Malinowski. 1982 enters the Conservatoire National Supérieur de Paris and trains with Serge Golovine.
1986 joins Les Ballets de Monte-Carlo, a newly created company by H.R.H Princess of Hanover directed by Pierre Lacotte et Ghyslaine Thesmar. He performs the Ballets Russes repertoire (Le Prince Igor, Le Fils prodigue, Shéhérazade…) and the choreographies of Pierre Lacotte. Also performs the creations of guest choreographers like Denis Wayne and particularly Le Mandarin Merveilleux of Jean-Christophe Maillot invited in1987. The encounter between the two artists creates a mutual impact that marks the beginning of the collaboration lasting since 25 years.
1988 He follows Jean-Christophe Maillot to the Ballet du Grand Théâtre de Tours where he performs his choreographies : Cliché I, Cliché II, Cliché III, Thème et quatre variations, Le Jardin jeux d'amour, Lundi matin 11 heures, Le Voyage d'hiver, Du haut de..., Ubuhuha, After All, Naranjas e citrons (in collaboration with Ramon Oller), Lueur d'amour, Casse-Noisette Circus. In the frames of the Festival "Le Chorégraphique" created by Jean-Christophe Maillot à Tours, he collaborates amongst others with Christine Bastin, Jean Gaudin et Ramon Oller.
1993 Returns to Monaco where Jean-Christophe Maillot is appointed Choreographer-Director of Les Ballets de Monte-Carlo. He will perform the major roles of Jean-Christophe Maillot's ballets that are mainly created for him: Home sweet Home, Dov'è la luna, Vers un pays sage, Concert d'Anges, Roméo et Juliette, Duo d'Anges, In Volo, Recto Verso, l'Ile, Cendrillon, Opus 40, Entrelacs, Œil pour Œil, La Belle, D'une Rive à l'Autre, Noces, Miniatures, Le Songe, Faust, Altro Canto II, Fauves, Norma mise en scène pour l'Opéra de Monte-Carlo, Shéhérazade, Daphnis et Chloé, Opus 50, Lac, Choré.
He collaborates with great number of contemporary choreographers invited to create for Les Ballets de Monte-Carlo and most of them for Gaëtan Morlotti: -Chris Haring – Sacre The Rite Thing / Maurice Béjart - Le Sacre Du Printemps, Boléro / Jiri Kylian - Bella Figura, Sechs Tänze, Return To A Strange Land - Svadebka (Les Noces) / Millicent Hodson - Le Sacre Du Printemps / Johan Inger - Walking Mad / S.L. Cherkaoui - Mea Culpa / Lionel Hoche - Balistik - Petite Pièce d'Extérieur, Hiatus / Jacopo Godani - Beyonders - Getting Started / Lucinda Childs - The Chairman Dances / Itzik Galili - Blue Grass / Kevin O'Day - The Time It Takes / Marcia Barcellos - Very Small Creatures / Lucinda Childs - Concerto / Serge Bennathan - Image D'une Traversée / William Forsythe - The Vile Parody Of Address / Nacho Duato - Duende / Angelin Preljocaj - Le Spectre De La Rose / John Neumeier - Petrouchka / Karole Armitage - I Had A Dream / Bertrand D'- Dichter Liebe
2002 In the frames of Monaco Dance Forum Gaëtan Morlotti starts very productive choreographic life. Le Spectre éléctrique is his first performance realised with DJ Spooky. In 2006 collaborates with the painter Ernest Pignon-Ernest for the itinerary in the city of Brest in homage to Jean Genet. 2007 Creates the choreography Mu for the School of Rosella Hightower in Cannes and assists Jean-Christophe Maillot for the conception of the Jeux des Petits Etats d'Europe opening ceremony in Monaco. 2009 Creates in the frames of the Centenary of the Ballets Russes a Hommage à l'Après-Midi d'un Faune and participates many times with his choreographies within the festival Printemps des Arts in Monaco. For les Ballets de Monte-Carlo and in the frames of the Young Choreographers evenings he creates: Entre temps, Les Echevelés, Des-compositions 2012. Forms also the group " Small Bang" with whom he creates several performances, notably Variations pour les colonnes presented at the Monaco Dance Forum.
Since 2010 Gaëtan Morlotti is leading the pedagogical projects and works with students in the collaboration with the National Education of Monaco.


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24Mar 14
Chicken Bacon Bites
Just a quick note: I've been making rolling changes to the recipe based on errors that people have found. Fixed one thing, broke another (missing pineapple juice)… Should be good to go now.
Just a quick note: I've been making rolling changes to the recipe based on errors that people have found. Fixed one thing, broke another (missing pineapple juice)… Should be good to go now.
Where ya been???
Also you said to have published this on march 25 but today is the 24th my good friend
Not gonna lie…I'm leaking clear stuff over here.
As much as I like bacon man, you have 45kg down there. Fucking great recipe though.
I used to make these with just pineapples no chicken, this looks much more better.
this is great ! for any occasion ! yust finish watching with my mom and she got motivated! <3
That ending! Nice job, I really liked the "top gear" style "some say, it might melt your brain"beginning 🙂
Where'd that pineapple juice come from?
How about some bbq or hot sauce on the side for dipping pleasure
Amra, 450g is not 45kg.
"Combine the chicken with the pineapple juice"
You never told me there was pineapple juice? How much pineapple juice? How can I enjoy Odin's savory delights without knowing how much pineapple juice to use?!
It says as the last ingredient, 1 cup of pineapple juice! 🙂
Where have you been! We've gone through the cookbook and all the recipes on the site and are now starving!
Looks awesome. Quick question: do you think those would be good eaten cold, too? I've got something coming up where I would have to prepare them the day before, keep them in the fridge and serve them cold the day after, and I won't have any way to reheat them.
Check it again, under the section in bold large font "Everything You Need" right most box, clearly says "Pineapple Juice: 1 cup"
This is kind of like a heart-stopping creation I made a while back. Wrapped sliced bites of a pineapple brat in bacon and dropped 'em in a deep fryer.
would want to use a substitute for the bacon, coz… gross.
How is this with other juices? Namely orange. I'm not a big pineapple fan but this sounds dope otherwise.
Sounds awesome!
Gross?! Bacon, gross?!? Um… right. *backs away slowly*
Actually I think I may make these for dinner tomorrow. I'd make them tonight but I've already got bbq pulled pork and mac n cheese.
Just made this and I figured I'd immediately share the love it received by everyone. Damned good.
omg these look so good. Drools.
Will be making these this weekend 🙂
I made them last night for dinner. Wish I'd taken a pic, they came out so pretty. And yummy! One tip, though. Use thin sliced bacon to wrap your chicken pieces. I used thick sliced and the bacon kind of overwhelmed everything else.
I have tried this recipe with quail, and it worked wonderfully. Also, people are always impressed with substitutes to chicken (as if it makes anything more difficult).
So awesome, made 'em tonight and they came out great. Drizzled the drippings on my pasta salad, so good.
These are delicious! Here are my tips.
1. If you don't have pineapple juice, mix some lemon juice with water and add some sugar in till it doesn't taste too sour.
2. If you don't have tooth picks, just try to place them seam-side down, so they stay put.
3. PAY attention to the cooking picture, that wire rack is a must, or else they will get soggy bottoms.
I made these last night and they were very delicious. Thank you!
I used cheap fatty bacon which fell apart, making wrapping the chicken slightly difficult.
Just had these for dinner – they were AMAZING. They did blow our faces off tho – if you're not so keen on the spicy I'd recommend dialing back the chilli powder
I would suggest one small change if you're still updating this. Add 1 Tbsp table salt (2 if kosher) to the pineapple juice & stir to dissolve. This turns the juice into a brine and makes the chicken juicier & more tender when you cook it.
How spicy does the chili powder make these?
I'm wanting to make them and my girlfriend is EXTREMELY sensitive to spicy foods. I would assume the brown sugar nullifies a lot of the spiciness, but I also love spicy foods and have trouble recognizing when something might be too spicy for someone who doesn't.
Hate to say this, but the images seem broken
40 minutes is way too long, unless you like your chicken drier than Arica (Chile). You're making chicken, not baking a cake.
I use 1 or 2 teaspoons of the chili powder when I make them for gaming group, since a couple of folks can't handle spicy. You can taste the chili powder at that point, but there's no burn at all. I kick it up when I make them at home, we LIKE spicy.
Holy guacamole! I just made these for my family for dinner, and everyone loved them!
Just wondering if these would be suitable to freeze? I'd love to be able to get them all set up and then pop em in the freezer to cook later
Thank you!
Stoked to try these!
You should totally do some buffalo chicken bites or stuffed jalapenos next! Spice things up a bit.
Just made these. Had a bit of bacon left over so I combined it with the left over pineapple juice and the brown sugar/chili mixture and threw it in a frying pan and fried it. It was a good snack while the rest of it cooked. 😀
Dude…. FYI, WE MISS YOU!
I love your comic (and cookbook). Are you going to make another book?
While the recipe is awesome, and I'm gonna try it soon, is there a sub I can put in instead of pineapple juice? (I'm kiiiinda allergic ^^;;)
Also, you spelled MacGyver wrong. There's no "u" in MacGyver, only a "y," as in "why not?".
You have an amazing skill. It was deelish!
This is how you get people to cook. Bought the book just to support.
[…] to do a recipe from http://www.cookingcomically.com. Specifically, he begged me to review this recipe of Chicken Bacon Bites aka Heaven on a stick. Personally, I'm a little wary, as I'm not a fan of pineapple, but chicken and bacon […]
Hi there! Your recipies are real good/funny/tasty/badass and I have been a viewer for about a 2 years and enjoyed it every strip. I still check for your recipes every two days to see if there is a new one. I am just wondering if you will ever really come back/do more since you stopped after March last year?
PS Screw the chumps up there telling you your shits not the most mindblowing food since Nutella Sandwiches.
Friggin' awesome! Tried this, -felt my penis move! It was that great!!
1 year without a new recipe….. everithing is ok?
Come back.. Post more of these, this concept is absolutely awesome.
I made these with mango juice rather than pineapple juice (because it's what I had on hand) and it's amazing!
WAAAAAY to much chilli powder otherwise awesome
Over a year since your last post. Hope everything is ok and you start putting up more fun stuff to do in the kitchen.
Too much chili powder? I add a little more!
I was somewhat forced to use turkey as a substitute for the chicken, but it was just as awesome.


text:
Last week a friend sent me this:
Best-seller Success Stories that Started Out as Self-Published Books
I have been stressed over sending query letters and having to justify why publishers should even read Heartshire High in the first place. I am not great at 'shameless' self promotion, and so I wonder if I'm losing out because I cannot promote myself Kardashian style....
My initial reaction to the idea of self publishing was NO WAY! How on earth can I publish a book myself and finish high school? I could imagine my dad going mad, wondering why I wasn't studying, or why I was on Amazon all night long (formatting not shopping!), or dropping out of school to write (eeerr.... not yet), but the idea has stuck in my head, partly because of these sentences:
"Stephen King wrote his first novel, "Carrie," and it was rejected 30 times. Rejections were so devastating that he threw the manuscript in the trash. "Chicken Soup for the Soul" was rejected 140 times. Margaret Mitchell's "Gone With The Wind" was rejected by 38 publishers (and she did give a damn). James Joyce's "Dubliner" was rejected 18 times and took nine years before it reached publication."
If these extremely successful writers have been rejected so often, what hope do I have? I know in my heart that Heartshire High is an amazing book, and that teenagers all over the world will love it (not to mention adults too!). But can I really wait nine years to publish it? Or get rejected 140 times???? - this is my worst nightmare.
Maybe I should publish the novel myself?
I wonder how difficult it is? Could I possibly do it in one summer? It would be a challenge but I'm sure it's doable...or is it mission impossible? Should I keep submitting the manuscript to publishers to speed the 30 odd rejections up!!?
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About Charlotte
I'm a high school senior who loves to read, write, read about writing, and write about reading. My first novel, Heartshire High, is out now!
March 2018


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The iconic French newspaper Le Monde is about to begin a new chapter of its complicated history. Last September, what remains France's most influential paper changed hands (see previous Monday Note Le Monde's escape velocity and story in NY Times' DealBook).
Le Monde is now owned by a triumvirate: Xavier Niel, a telecom entrepreneur, provided the bulk of the €110m ($130m) injected in the venture; Matthieu Pigasse, head of Lazard France, and Pierre Bergé, co-founder of Yves Saint-Laurent fashion house. Now, as the paper prepares to replace its editor, the new owners' turnaround operation faces tough challenges.
But, before we continue, a disclosure that might influence the way you read this column:
Over the last few days, I have been on the receiving end of feelers from both insiders and outsiders: they wanted to gauge my interest in Le Monde's editor job. (None of these informal conversations directly involved the owners.) For reasons I'll discuss towards the end of this note, I made it clear I wasn't interested. Frédéric Filloux
French unions and government have killed their print media. The government almost edits the papers; it controls far too much. People will eventually realize they need a democracy without the enarques running everything.
I agree with you for the "Parisien" I don't miss its news on Twitter
I didn't find that "Bakchich" was worth reading, I tried sometimes but had the impression that it works more with rumors
Mediapart is a lefty media, and the Bettencourt subject is a non-event, just covered to destabilize the government when it was trying to reform retirement
I find La Tribune and the Echos fairly informative, I rarely read Le Monde, except its foreign policies analyses
"French press has lot of default, principal is too much editors, writing articles not for readers, but for them."
yes, they want to make a style exercice
Fortunately we have internet, and we can cross the news fom all over the planet now
French press has lot of default, principal is too much editors, writing articles not for readers, but for them. They missed internet, running to come back, only few with success. Modernization takes time.Using internet need strategy. You have to bring high quality content, not the same as our competitors, and find business with this content. You can have a look about Web Tv www.labourseetlavie.com as example. The editor Didier Testot produced more than 600 videos (interviews with ceo, assets managers..debate) not with a big team, not with a lot of money, but with lot of ideas and a brand strategy. Internet give this opportunity.
I don't understand why Le Parisien doesn't get more national and international respect and why everyone kowtows to Le Monde. I don't think I've ever read a controversial (to the French intellectual establishment) statement in Le Monde.
Le Parisien actually does investigative journalism and annoys the big guys. It's often the first to report some story that the newspapers all take up. It broke the Clearstream affair, the Péchenard affair, the famous "pauv' con" video of Sarkozy and so many others. Just a couple of weeks ago it reported that the government was planning to sell car registration records to the highest bidder.
In September Rue89, the blog of French journalists off-duty, wrote in relation to a possible purchase of Le Parisien by Dassault (which luckily didn't happen), "The Parisien at the moment shows its independence of political power, bringing out scoops on the left and the right." [Reste que Le Parisien-Aujourd'hui en France fait pour l'instant preuve d'indépendance vis-à-vis du pouvoir politique, sortant des scoops sur la gauche ou sur la droite]
Le Monde, I read it only to see what idées reçues are coming in and out of style.


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Contact Us
Dan Hebert, Editorial Team
E: email@example.com
Dan Hebert is a Contributing Editor for Control and Control Design magazines. He began his career at Putman Media as a Field Editor in 1995 and joined the company on a full-time basis in 2000.
Mr. Hebert has 25 years of experience in the process control industries. He worked for 22 years as an end user at a process plant, as a systems integrator, as an employee of a skid builder, and as an employee of a major engineering and construction firm. His employment duties included plant operations, control systems programming, detailed design, project management, line management, and sales. Hebert has a PE in Control Systems and is a patent holder for a closed-loop control system. He holds a BSEE and an MBA and is a member of ISA and of Eta Kappa Nu, the engineering honor society.


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Great Britain signed a new defense treaty with Ukraine to help fight against aggression of the Russian Federation, stated Defense Secretary of GB Michael Fallon, reports Telegraph.
According to Fallon, the treaty presupposes that British troops will take part in mutual military trainings with Ukrainian Armed Forces.
Moreover, Fallon noted that the countries will also cooperate in exchange programs in the fields of military intelligence and expertise.


text: The Teenage Mutant Ninja Turtles have been a favorite of mine since the 1980s. Beyond watching the cartoons and movies, I was able to bring them to life in a major theme park during the early 90s. For this project, I was asked to create a little art for a new Turtle fan's birthday. The media is acrylic on connected 12" X 12" canvases.


text: Hello, welcome to my new blog and website. I previously used anthonytavisfolkart.blogspot.com as my blog, and it still exists, however, I'm not sure what I'm going to do with it yet. This is the inaugural new blog post and I want to tell you what I'll be serving up here. I am a people person by nature. The fun part about being an artist, and doing all these art festivals is that I get to meet some really amazing people and go to some interesting places along the way. I will be sharing those experiences, past and present here with you my readers. I will also post information on what I'm working on and what events I will be participating in in the future. In regards to making my art available for purchase online, that is coming soon! (I have some things to iron out before I go live with that). I encourage my readers to subscribe, and comment as often as you like. Thank you all visiting AnthonyTavis.com.


text: Our specialist neuro-physiotherapists are trained in the management and care of a range of conditions such as stroke, multiple sclerosis, Parkinson's disease and head injury. Patients suffering day to day difficulties due to loss of movement, sensation, balance or co-ordination will benefit enormously. Treatment involves a programme of exercises, on-going rehabilitation and advice in the clinic, at home or in a nursing home and includes help and advice for carers/relatives.


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BIRMINGHAM gangsters are training killer pit bull terriers to use as weapons, instead of knives and guns, RSPCA officers believe.
They revealed their fear as they swooped on homes and seized three dogs, thought to be pit bulls, suspected of being trained for fighting.
A man and a woman were arrested by police during yesterday's joint operation by the RSPCA Special Operations Unit and West Midlands Police.
The raided homes in Kennet Grove, Chelmsley Wood and Holly Road, Handsworth, though there is no suggestion the occupants there have gangster links. But the RSPCA believes gang members and robbers in the city may be ditching guns and knives in favour of dogs who they are training to attack, maim and kill.
Chris Heyworth, from the RSPCA Special Operations Unit, said the trend towards pit bull terriers being trained by robbers may be linked to rap stars using them in videos.
He said the animals were being used as weapons and seen as a status symbol.
"If someone is stopped on the street and found to be carrying a gun, they will be arrested immediately, but it's not an offence to have a dog with them.
"Yet these dogs are trained to attack on a trigger word and can kill, just the same as a gun.
"They are being used as weapons and are quite an effective weapon."
His colleague Ian Briggs also revealed there is a "particular problem" in Birmingham with organised dog fights.
He said: "We have major concerns about dog fighting in the West Midlands.
"Nationally we've had lots of reports of dog fighting but there seems to be a particular problem in Birmingham with fights on park land and also organised dog fighting in buildings.
"It's a major problem at the moment. An organised dog fight can last for two hours after which one or both dogs can die.
"Dogs can go from one fight to the next and we've seen evidence of people gluing wounds, stapling them and stitching them up themselves. It's a wretched life for these animals."
At the house in Kennet Grove, two young dogs, thought to be pit bulls were found in a back garden.
The dogs, aged between six and 12 months old, bore scars RSPCA officers feared had been inflicted during savage fights.
Police also seized what is believed to be crack cocaine and hundreds of pounds in cash, together with a stash of photographs featuring dogs suspected of being used for fighting.
A man was arrested on suspicion of using the animals for dog fighting.
Police and RSPCA officers also searched a second house in Holly Road, where another suspected pit bull was seized and a woman arrested under the Dangerous Dogs Act.
Sgt Rachel Jones, of Chelmsley Wood police, said the operation followed tip-offs from the public.
"Members of the community were concerned about the welfare of these dogs and we've acted on their information."
A West Midlands Police spokesman said the breed of the the animals is being determined, but they are believed to come under the Dangerous Dogs Act.
A man, aged 27 and a woman in her 20s, are helping with inquiries.


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9: Using Meditation to Overcome the Trauma of Pregnancy/
"The midwives wanted to send me home with some Panadol, giving me the instructions to return in two days when the contractions were more serious - the baby was out in six hours" - Maria Phillips.
In this episode Maria Phillips joins the podcast and discusses how guided meditation, mindfulness and education helps with having a 'Calm Birth' . These lessons are then applied to the wider context of every day life and other traumatic events.
The episode ends with a Q&A session with listener questions for Zachary.
Related resources:
What to Buy When You're Expecting – a Comprehensive List of Items and Helpful Resources for Expecting Parents (blog)
The Joys and Challenges of Parenthood (podcast)
Having a Child Isn't as Bad as Everyone Says It's Going to Be (blog)
Advice to Expecting Parents from a New Father (video)Info on 'Calm Birth' can be found here
Support The Reality Check Podcast on Patreon
Check out my Blog | Videos | Books


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This course provides you with the concepts and skills to use HTML and HTML5 effectively. You get hands-on practice working with basic through advanced techniques to get the most out of your experience. You will learn the basics of coding for web design, beginning with HTML and advancing to more complex HMTL5 and CSS and Scripting fundamentals.
This course is intended for students wishing to learn HTML,CSS and Scripting.
Upon completion of this course, students will be able to:
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• Design elements- color, background, and page layout
• Understand the basics of graphic
• Understand the basics of CSS & Scripting
• Upload to a live site.
Students must have a good working knowledge of computers, operating systems, using a mouse, keyboard, standard menus and commands. Students must be able to open, save, and close applications, files, as well as navigate to other folders.
At Life Way Tech India, we provide an excellent and high quality Training. We have a team of highly skilled professionals to equip you and build a strong foundation. The curriculum can be customized as per individual's need.
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Sudents. Know more about Life Way Tech India Training admission process please call @ +91-9001627655.


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Product QuestionsNo questions yet. Be the first to ask the question!


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- puntos de vista: 27748
- gustos: 60
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GAMSTOP – is also now live and lets you put controls in place to restrict your online gambling activities. You will be prevented from using gambling websites and apps run by companies licensed in Great Britain, for a period of your choosing. ? 18+ Only


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A public swimming pool in New York City has reinstated sex-segregated swimming hours at the request of the local Hasidic Jewish community.
The pool, located on Bedford Avenue in Brooklyn, had hosted sex-segregated hours for two decades until, according to the Forward, administrators had intended to suspend the practice after the New York City Commission on Human Rights warned that it violated city law.
"It is a question do we believe in equality or not?" Rabbi David Niederman told the Forward. "Is our interest to ensure that every citizen should have the opportunity?"
Niederman, who represents the United Jewish Organizations of Williamsburg, argued that Hasidic women would be particularly harmed by the pool's decision to end the practice.
"Women are more homebound….Especially women who have a lot of children, that type of exercise [swimming] is very healthy for them. Depriving that…it hurts," he said.
But Hasidic women already have private, sex-segregated swimming options in Brooklyn. The Boro Park Y and Shorefront Y both offer women-only swimming hours. It's not clear why Hasidic women apparently prefer the public pool to these options, but their ability to swim in a manner that conforms to their religious practice is not actually dependent upon a public facility's decision to accommodate them.
This also isn't the first time the Hasidic community has asked the Bedford Avenue pool to accommodate them in ways that may violate the First Amendment. The Forward also reported that in 2013, community leaders asked the pool to hire female lifeguards to work exclusively during women-only swimming hours. That's an obvious violation of federal and state anti-discrimination law, and the pool rightly refused to accommodate the request at the time.
Agudath Israel's Rabbi Avi Shafran disagreed with ending the religious accommodation at this public facility.
"Rescinding the special sex-segregated hours would be the equivalent of a sign saying, 'No people with traditional values allowed," he wrote in an email to the Forward. "The classical concept of modesty that is embraced by many citizens may have its roots in religious systems. But reasonable accommodation of the needs of such New Yorkers is not an endorsement of any religion."
Shafran's argument — that people of faith are entitled to certain reasonable accommodations ---is technically true. It simply doesn't apply in this case. After all, it is not reasonable or appropriate to ask a public entity to ban taxpaying citizens from using a public pool at certain hours on account of their sex purely to accommodate one religious group. It is particularly egregious to make this request when sex-segregated options already exist.
Pluralism, as defined by the U.S. Constitution and interpreted by the courts, asks us to accommodate certain beliefs – as long as there is no third-party harm. But there is a significant difference between respecting a person's right to swim only with other self-identified women, and forcing others to observe the same religiously-motivated practice.
"There is no just way to tell a sweaty Brooklynite on a Sunday afternoon that he should be ejected onto Bedford Avenue because one religious group doesn't want him in the pool," The New York Times editorial board wrote yesterday. "Let those who cannot abide public, secular rules at a public, secular pool find their own private place to swim when and with whom they see fit."
Sex-segregation at public pools forces non-Hasidic residents to abide by the dictates of a faith that is not their own. It's time for the Bedford Avenue pool to desegregate.
Follow Sarah Jones online at @onesarahjones


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Samuel Leung earned his Doctor of Osteopathic Medicine degree from the New York Institute of Technology College of Osteopathic Medicine in Old Westbury, New York. He served his internship and residency at Clarion Hospital in Clarion, Pennsylvania.
Dr. Leung is dedicated to caring for each patient as a whole person: mind, body and spirit. Outside the office, he enjoys calligraphy, drawing and painting.
Asante's online provider directory, ("Find A Doctor"), is provided for reference purposes only. Providers are responsible for the accuracy of the information submitted. As such, Asante cannot guarantee that the physician information presented is complete or accurate. Asante recommends that you contact your healthcare provider directly for the most accurate and up-to-date information.
Providers who would like to report inaccurate information on their profile may contact email@example.com, information will be routed to the appropriate Hospital credentialing staff.
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Lesson contents in April, 2019
【1】Short experience class for foreign tourists....1 kind of "Nerikiri"Wagashi.
....2 pieces
1 to eat
1 to go (with plastic container)
at the normal temperature...good till 2 days after.(freezing O.K.)
【2】Standard class for foreign resident and Japanese・・・2 kinds of wagashi, "Uirou" and "Konashi"
Kabuto(Samurai warrior helmet)....2 pieces ("Uirou Wagashi")
at the normal temperature...good till 2 days after.
Koinobori(Carp-shaped streamer)....1 piece each color ("Konashi Wagashi")
at the normal temperature...good till 2 days after.(freezing O.K.)
Plastic containers, box, and plastic bag to go.
Wagashi are fresh sweets.After you take back,please keep them at a cool place with no direct sunlight.
If you don't eat soon, we recommend you to freeze "Bara" and "Koinobori".You can eat in a good taste by defrosting from 2 to 3 hours before eating at the normal temperature.
After making Wagashi,we make Matcha green tea and eat one of Wagashi. Lecture and questions.
If you are a vegetarian or have any allergy, please check the ingredients. If you want to make without some ingredients, ask us on the email. We might change the recipe.
Bara(Rose)...white kidney beans, sugar, starch syrup, Shiratama rice powder, potato starch, azuki beans, food coloring(cochineal extract...insect direved)
Kabuto...Joyo rice powder, Mochi rice powder, sugar, white kidney beans, Kuzu starch, potato starch, orange peel
Koinobori...white kidney beans, sugar,weak flour, Shiratama rice powder, Azuki beans, potato starch, food coloring(gardenia blue...plant derived(includes lactose,soybean), cochineal extract...insect derived)


text: Finding the Best Makeup for Acne Prone Skin Acne Recommended: Use a voucher code MAS5385 to save an extra 5% when shopping for supplements on iHerb. There's nothing more embarrassing than a breakout before an important date or a job interview. Luckily, you can use modern-day makeup to cover a good portion of your blemishes. It takes a little bit of experience, but there's no reason why you can't glam it up for a fancy event. Of course, there's always the danger of making your acne worse which is why you have to be careful. Choose the right products and exercise a little self-restraint. With proper planning and solid techniques, you'll be able to hide your acne while preventing future outbreaks. Here are some handy tips when it comes to finding and applying the right makeup for your acne prone skin. The Right Facial Foundation A lot of women immediately reach for a liquid foundation because it provides the most coverage. Just keep in mind that liquid foundations have a tendency to clog pores and get mixed up with oil and dead skin cells. It's also essential that you find the right color to match the tone of your skin. It takes a bit of work in research to find the perfect color, but it's well worth it in the end. You can have your skin professionally matched by a specialist, or you can do it by yourself quite easily. You can also ask for samples to do a bit of experimentation. In general, try to pick three colors that you think fit the best and then try them all at home. Do it in different lighting and see what happens if you mix them together. Choose Mineral Makeup Rather than going with a liquid foundation, acne prone skin works better with mineral makeup. It's lighter and has less of a chance of clogging. Something like Almay Pure Blends Mineral Foundation is affordable and applies easily. This way you can also use a brush that is less likely to aggravate your skin and cause future breakouts. It's also easier to fix up minor mistakes when using mineral makeup. Good Techniques Applying makeup isn't just about rubbing something all over your face, you have to use care and proper technique. For acne prone skin, a gentle dabbing motion is more effective than circular rubbing. Most importantly, make sure that any tool that you use is cleaned properly beforehand. You don't want to be spreading bacteria all over your face, and this applies for your hands as well. And if you're in the process of experimenting, make sure to give your skin a break so that you don't spend the entire day with different types of makeup on your face. Acne Concealers After you have a good foundation, you can also apply an acne concealer to further hide the problem. Your concealer should match the tone of your foundation which hopefully matches your face as well. In order to give yourself an extra boost of treatment, you can find medicated product that conceals as well. Neutrogena happens to have a great one that works well to prevent acne and blackheads. Just be careful because you don't want to overload your face with chemicals if you're also using a medicated cleanser and topical cream. Maintain Good Skin Habits You have to remember that finding the right makeup isn't a cure for your acne. Some women think they found a great combination to hide their flaws and unfortunately don't work on prevention. Just because you can hide your acne today doesn't give you free license to do whatever you want with your skin. Make sure you maintain good habits and always wash off your makeup thoroughly before you go to bed at night. Having a great skin isn't just about vanity, it's about getting your self-confidence. Finding good makeup gives you a bit of leeway and this can give you the time you need to explore other acne treatment options. Leave a Reply Cancel Reply Your email address will not be published.CommentName* Email* Website Save my name, email, and website in this browser for the next time I comment.


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Over the years, Dewulf has made dozens of harvesters that fit the specific needs of its customers. Based on years' experience in the manufacture of carrot and potato harvesters, Dewulf can offer harvester technology that is adapted to your specific crop.
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Ph 08 8578 1037 Fax 08 85781258


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Posts tagged 'tech talk'
Free Pizza. Free Inspiration. And Some Startup Chatter.
Innovation Park at Notre Dame (1400 E. Angela Blvd) is hosting Tech Talk: How Tech, Art & Design Create Great Startups on Thursday, January 24th at 6pm. Co-Founder Moses Lee will share his experience of bringing Seelio "to life using innovative technologies and human-centered art and design principles." Seelio is a venture-backed tech startup that "is a stage for college students to distinguish themselves and connect with companies." This event is free and the organizers are providing free pizza, t-shirts and a plethora of "cool swag." Need more reasons to go? I bet you'll be INSPIRED! If you're planning to go, help the organizers by RSVPing: http://techtalk1.wufoo.com/forms/tech-talk-rsvp/


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about six years ago
Pictured left to right: kneeling Justin Harvey, Miles Nielson. Standing Zach Ballinger, Jason Pokalsey, Roy Butts, Trenton Chepan, Head Coach Nate Graham. Not pictured Matt Simpson.
Central A & M Football team has concluded their 2013 football season.
Each week of the season, a player who stood out for their hard work and dedication was recognized as being Player of the game.
Week one award went to Trenton Chepan, week two and week seven was Roy Butts, week three and week eight went to Jason Pokalsey, week four Zach Ballinger, week five was Justin Harvey, Miles Nielson receiving the award for week six, and week nine went to Matt Simpson.
Central A & M Head Football Coach Nate Graham tells Regional Radio despite the down season as they finished with a 1-8 recod, he is very proud of his team:
[audio:grahamproud103013.mp3]comment here[/audio]
2019 Taylorville Daily News,
Miller Media Group
Built on Envisionwise Technology. Administrator Login


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CREDITS: Many thanks to Ryan Niemeyer for his review and feedback on this article.
One of the more valuable JavaScript concepts I learned after starting work with the awesome folks at appendTo last year was the idea of using mixins for common functionality that you want to share across multiple objects/modules in your code. It was so valuable in fact that I'm a little embarassed that it has taken me this long to share the idea (not that it's a new concept in general), because I've been surprised at the relatively few number of people I've encountered since that were aware of the technique. So I decided that I needed to write about it.
What is a mixin?
In object-oriented programming languages, a mixin is a class which contains a combination of methods from other classes. How such combination is done depends on the language, but it is not by inheritance. ...A mixin can also be viewed as an interface with implemented methods. When a class includes a mixin, the class implements the interface and includes, rather than inherits, all the mixin's attributes (fields, properties) and methods.
This is helpful for understanding the intent of a mixin, but the application is slightly different in the context of JavaScript of course, it being a dynamically typed, interpreted language. In this context, mixins allow the developer to dynamically add functionality, defined in a single place (this is where the DRY part comes in), to other modules within your code.
This is probably most effectively understood with a good example...
Something simple
I'll start with a very basic example, and then we'll take a look at something a bit more practical to help illustrate how mixins work.
Let's say you want to be able to log messages to the browser console, but only if/when the console object is actually available (so your app doesn't throw JS errors on older browsers that don't expose a console object), but you don't want to have a bunch of
if checks scattered everywhere you want to write stuff to the console in your code. So let's create a simple mixin with a single
log function.
(function () {
var Logger = {
log: function (message) {
if (window.console && typeof console.log === "function") {
return Logger;
Now let's create an object that will need to be able to log stuff to the console, and use our the
log function from our mixin to handle it:
(function (_, Logger) {
var MyObject = function () {
this.doSomething = function () {
this.log("My Object is doing something!");
// This copies the members of the `Logger` object onto the prototype of `MyObject`
_.extend(MyObject.prototype, Logger);
return MyObject;
}(underscore, Logger));
Now, when we create a new instance of
var obj = new MyObject();
This instance has a function on it called
log that was copied on to it from our mixin, which we can call from inside the
doSomething function:
// "My Object is doing something!"
Hopefully that makes sense...now let's take a look at something a bit more practical...
A reusable AJAX call
One area that a lot of code-bases that I've worked with could benefit from some reusable code is with AJAX calls. I've seen a LOT of applications that have something very much like this, sprinkled around in dozens of places in their code (THIS is what we want to fix):
url: "http://example.com/foo",
type: "get",
contentType: "application/json; charset=utf-8"
.done(function (data) {
// ...
.fail(function () {
// ...
Lets take a look at how we can fix that by creating a mixin that we can use in all of our objects that need to be able to make AJAX calls to the server.
Define it in one place
So, let's create our mixin: an object that has a function to take the appropriate parameters and executes an AJAX call:
(function (_, $) {
var Requester = {
_mapRequestData: function (request) {
var mappedRequest = {};
_.each(request, function (value, key) {
mappedRequest[key] = this._executeOptions[key](value, this);
}, this);
return mappedRequest;
_executeOptions: {
url: function (target, context) {
return target;
type: function (target, context) {
return target;
contentType: function (target, context) {
return target;
context: function (target, context) {
return target;
data: function (target, context) {
if (context[target]) {
return context[target];
} else {
return target;
dataType: function (target, context) {
return target;
done: function (target, context) {
return context[target];
fail: function (target, context) {
return context[target];
execute: function (options) {
var self = this;
if (!options && !options.url) {
options = this._mapRequestData(options);
var request = $.ajax({
url: options.url,
type: options.type || "get",
contentType: options.contentType || "application/json; charset=utf-8",
data: options.data || {},
context: options.context || self
if (options.done) {
request.done(options.done.bind(options.context || self));
if (options.fail) {
request.done(options.fail.bind(options.context || self));
if (options.always) {
request.done(options.always.bind(options.context || self));
return request;
return Requester;
}(underscore, jquery));
OK, so there we have a nice, self-contained module that returns an object literal called
Requester that we can now mixin to any other module in which we need to make AJAX calls. So now lets take a look at how we would do that.
Dependencies and inner-workings
Before we get into that, real quick, lets talk about dependencies, and the inner-workings of how this works...
You could do this yourself, but I've never been a big fan of reinventing wheels. I typically try to take advantage of the hard work of others when they've been so generous as to share that work with us. There are basically two libraries that I use to handle mixin functionality, and this has never really been a problem for me, because I honestly can't remember a project that I've worked on that didn't have at least one of these libraries (if not both) available: jQuery and underscore.js. Both of these libraries provide an
extend function that provides, effectively, the same functionality, though the syntax between the two differs slightly, so I'll provide examples of how to use this mixin with each of those functions.
What the extend function is going to do for us, is copy all of the functionality from a source object, to a destination object, attributes, functions, etc.
The underscore.js documentation describes it like this:
_.extend(destination, *sources)
Copy all of the properties in the source objects over to the destination object, and return the destination object. It's in-order, so the last source will override properties of the same name in previous arguments.
And the jQuery documentation is similar:
jQuery.extend( target [, object1 ] [, objectN ] )
Description: Merge the contents of two or more objects together into the first object.
The difference between the functionality of the two should be more obvious when you see the difference in usage syntax below.
OK, so lets take a look at how we would use these functions to pull our
Requester mixin into another object/module.
Mixin it up
Lets say we have a view object that will be responsible for updating DOM elements with the result of an AJAX call to the server. Here's how we would define that view, using the
Requester mixin we've already defined:
(function (_, $, Requester) {
// constructor function
var SomeView = function () {};
_.extend(SomeView.prototype, {
requests: {
getSomeData: {
url: "http://example.com/foo",
getSomeData: function () {
// this `execute` function is mixed-in from our `Requester`
onGetSomeDataDone: function (data) {
// Update the appropriate DOM elements with the returned `data`
onGetSomeDataFail: function (err) {
// Something went wrong...do something to indicate so to the user
// extend SomeView with our Requester mixin
_.extend(SomeView.prototype, Requester);
return SomeView;
}(underscore, jquery, Requester));
OK, so, lets take a little closer look at what's going on here...
First of all, notice how/where we're mixing in our
_.extend(SomeView.prototype, Requester);
Here's how you would do the same thing with jQuery instead:
$.extend({}, SomeView.prototype, Requester);
Recall what the documentation said about the
extend function. This call is literally adding the
execute function we defined in
Requester to the
SomeView object. So when we create an instance of
SomeView, it has the
execute function on it, just as if it were originally defined within
SomeView itself.
Also notice that the
execute function accepts an object that it uses in its execution of the
$.ajax call. This gives us a nice, clean way to pre-define the options we want to use for that call on the
requests property of our object, just as we did in
requests: {
getSomeData: {
url: "http://example.com/foo"
With all of that in place, now all we have to do is pass the
getSomeData request definition in to the
execute function, and our request will be submitted to the server.
Also notice that the execute function returns something. As of version 1.5, jQuery now returns a Deferred object from the execution of the
$.ajax function. The
Deferred is an implementation of the Promise pattern and provides a chainable object that allows us to attach callback functions to the execution of our
$.ajax request. This allows us to handle the results of the request in a clean, elegant and readable manner:
This gets the repetitive, boilerplate code out of the way, and still clearly shows the intent of the code.
The benefits
You might be asking yourself why this is such a big deal, so in case you are struggling to see the advantages of this approach to reusable JavaScript code, allow me to point out some of them here for you.
Reuse, elimination of boilerplate code
Notice that we no longer need to explicitly write out the repetitive calls to the
$.ajax function. It's now defined in one place, and we've effectively encapsulated the parts that vary as we should be doing. Now all we have to do is mix
Requester in to our object, and call
this.execute with the appropriate request definition, and we're done.
Flexibility and default values
You might've noticed that in our mixin, inside the
execute the function, when we call
$.ajax, when we're passing our options to it, note how we're doing so:
url: options.url,
type: options.type || "get",
data: options.data || {},
dataType: options.dataType || "json",
contentType: options.contentType || "application/json; charset=utf-8"
Take a look at the
contentType option for example. Notice that we're saying: "use the contentType that's defined on the
options passed in if it's defined, but if not, we'll go ahead and use
application/json; charset=utf-8 by default if it's not defined."
Now, notice how this allowed us to define our
getSomeData request with only a URL:
getSomeData: {
url: "http://example.com/foo"
We can do this because our mixin is assuming that if we don't define a
type on our request, it will automatically assume we're executing a
GET request, with a
dataType of
json and a
contentType of
application/json; charset=utf-8.
This same functionality allows us to easily override any of these defaults when a request needs to. Say you had a request where you were POSTing form data with the request instead of a JSON object, and were expecting XML back from the server instead of JSON (heaven forbid...). You could define your request to override the defaults like this:
getSomeOtherData: {
url: "http://example.com/bar",
type: "post",
dataType: "xml",
contentType: "application/x-www-form-urlencoded; charset=UTF-8"
Ultimately all of that is a significant win in our code.
Wrapping it up
After all of that, I hope you can see that the important takeaway from all of this is the high-level concept and benefits that JavaScript mixins can give you. It's not really about the AJAX, that's just the example use case. The possibilities are endless really. Any kind of code that would be common among many of the objects in your code would be a great use for a mixin. All of your objects need to be able to log messages? Create a logging mixin. Have a common messaging infrastructure that you use across your code? Wrap it up in a mixin and pull it in to the objects that need to use it.
Questions or comments? Know of a better way to do this? Let me know. Hopefully this was helpful to you.


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Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system and especially prominent in the human brain where it is the body's most prominent neurotransmitter, the brain's main excitatory neurotransmitter, and also the precursor for GABA, the brain's main inhibitory neurotransmitter.[1] Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Glutamate receptors are implicated in a number of neurological conditions. Their central role in excitotoxicity and prevalence in the central nervous system has been linked or speculated to be linked to many neurodegenerative diseases, and several other conditions have been further linked to glutamate receptor gene mutations or receptor autoantigen/antibody activity.
Glutamate (Glutamic acid) is the most prominent neurotransmitter in the body, and it is the main excitatory neurotransmitter,[1] being present in over 50% of nervous tissue.[2] Glutamate was initially discovered to be a neurotransmitter in insect studies in the early 1960s.
Glutamate is also used by the brain to synthesize GABA (γ-Aminobutyric acid), the main inhibitory neurotransmitter of the mammalian central nervous system, which plays a role in regulating neuronal excitability throughout the nervous system and is also directly responsible for the regulation of muscle tone in humans.[1][3]
Mammalian glutamate receptors are classified based on their pharmacology. However, glutamate receptors in other organisms have different pharmacology, and therefore these classifications do not hold. One of the major functions of glutamate receptors appears to be the modulation of synaptic plasticity, a property of the brain thought to be vital for memory and learning. Both metabotropic and ionotropic glutamate receptors have been shown to have an effect on synaptic plasticity.[4] An increase or decrease in the number of ionotropic glutamate receptors on a postsynaptic cell may lead to long-term potentiation or long-term depression of that cell, respectively.[5][6][7] Additionally, metabotropic glutamate receptors may modulate synaptic plasticity by regulating postsynaptic protein synthesis through second messenger systems.[8] Research shows that glutamate receptors are present in CNS glial cells as well as neurons.[9] These glutamate receptors are suggested to play a role in modulating gene expression in glial cells, both during the proliferation and differentiation of glial precursor cells in brain development and in mature glial cells.[10]
Glutamate receptors can be divided into two groups according to the mechanism by which their activation gives rise to a postsynaptic current.[11] Ionotropic glutamate receptors (iGluRs) form the ion channel pore that activates when glutamate binds to the receptor. Metabotropic glutamate receptors (mGluRs) indirectly activate ion channels on the plasma membrane through a signaling cascade that involves G proteins. Ionotropic receptors tend to be quicker in relaying information, but metabotropic ones are associated with a more prolonged stimulus. This is due to the usage of many different messengers to carry out the signal, but since there is a cascade, just one activation of a G-protein can lead to multiple activations. Glutamate receptors are usually not specifically geared towards glutamate exclusively as the ligand and sometimes even requires another agonist.
Of the many specific subtypes of glutamate receptors, it is customary to refer to primary subtypes by a chemical that binds to it more selectively than glutamate. The research, however, is ongoing, as subtypes are identified and chemical affinities measured. Several compounds are routinely used in glutamate receptor research and associated with receptor subtypes:
Due to the diversity of glutamate receptors, their subunits are encoded by numerous gene families. Sequence similarities between mammals show a common evolutionary origin for many mGluR and all iGluR genes.[13] Conservation of reading frames and splice sites of GluR genes between chimpanzees and humans is complete, suggesting no gross structural changes after humans diverged from the human-chimpanzee common ancestor. However, there is a possibility that two human-specific "fixed" amino acid substitutions, D71G in GRIN3A and R727H in GRIN3B, are specifically associated with human brain function.[14]
Mammalian ionotropic glutamate receptor subunits and their genes:[15][16]
Mammalian metabotropic glutamate receptors are all named mGluR# and are further broken down into three groups:
In other (non mammalian) organisms, the classification and subunit composition of glutamate receptors is different.
Glutamate receptors exist primarily in the central nervous system. These receptors can be found on the dendrites of postsynaptic cells and bind to glutamate released into the synaptic cleft by presynaptic cells. They are also present on both astrocytes and oligodendrocytes.[10] The glutamate binds to the extracellular portion of the receptor and provokes a response, but the various types of receptors can produce different responses.[11] Ionotropic and metabotropic glutamate receptors, with the exception of NMDA, are found on cultured glial cells, which can open in response to glutamate and cause cells to activate second messengers to regulate gene expression and release neuroactive compounds.[9] Furthermore, brain slices show glutamate receptors are ubiquitously expressed in both developing and mature astrocytes and oligodendrocytes in vivo. Because of this, glial glutamate receptors are thought to be vital for glial cell development.[10]
Ionotropic glutamate receptors, by definition, are ligand-gated nonselective cation channels that allow the flow of K+, Na+ and sometimes Ca2+ in response to glutamate binding. (In C. elegans and Drosophila, invertebrate-specific subunits enable the flow of negative chloride ions rather than cations.) Upon binding, the agonist will stimulate direct action of the central pore of the receptor, an ion channel, allowing ion flow and causing excitatory postsynaptic current (EPSC). This current is depolarizing and, if enough glutamate receptors are activated, may trigger an action potential in the postsynaptic neuron. All produce excitatory postsynaptic current, but the speed and duration of the current is different for each type. NMDA receptors have an internal binding site for an Mg2+ ion, creating a voltage-dependent block, which is removed by outward flow of positive current.[18] Since the block must be removed by outward current flow, NMDA receptors rely on the EPSC produced by AMPA receptors to open. NMDA receptors are permeable to Ca2+,[19] which is an important cation in the nervous system[20] and has been linked to gene regulation.[21] The flow of Ca2+ through NMDA receptors is thought to cause both long-term potentiation (LTP, of synapse efficacy) and long-term depression (LTD) by transducing signaling cascades and regulating gene expression.
Metabotropic glutamate receptors, which belong to
Neurodegenerative diseases suspected to have a link mediated (at least in part) through stimulation of glutamate receptors:[35][71]
Glutamate receptors have been discovered to have a role in the onset of epilepsy. NMDA and metabotropic types have been found to induce epileptic convulsions. Using rodent models, labs have found that the introduction of antagonists to these glutamate receptors helps counteract the epileptic symptoms.[69] Since glutamate is a ligand for ligand-gated ion channels, the binding of this neurotransmitter will open gates and increase sodium and calcium conductance. These ions play an integral part in the causes of seizures. Group 1 metabotropic glutamate receptors (mGlu1 and mGlu5) are the primary cause of seizing, so applying an antagonist to these receptors helps in preventing convulsions.[70]
[68] Furthermore, administration of noncompetitive NMDA receptor antagonists have been tested on rat models. Scientists proposed that specific antagonists can act on GABAergic interneurons, enhancing cortical inhibition and preventing excessive glutamatergic transmission associated with schizophrenia. These and other atypical antipsychotic drugs can be used together to inhibit excessive excitability in pyramidal cells, decreasing the symptoms of schizophrenia.[67].antipsychotics, a weak, nonselective NMDA receptor antagonist, was used as an add-on to clozapine therapy in a clinical trial. Refractory schizophrenia patients showed associated improvements in both negative and positive symptoms, underscoring the potential uses of GluR antagonists as Memantine Current research is targeting glutamate receptor antagonists as potential treatments for schizophrenia. [66]
In 1994, GluR3 was shown to act as an autoantigen in Rasmussen's encephalitis, leading to speculation that autoimmune activity might underlie the condition.[33]
Late onset neurological disorders, such as Parkinson's disease, may be partially due to glutamate binding NMDA and AMPA glutamate receptors.[37] In vitro spinal cord cultures with glutamate transport inhibitors led to degeneration of motor neurons, which was counteracted by some AMPA receptor antagonists such as GYKI 52466.[37] Research also suggests that the metabotropic glutamate receptor mGlu4 is directly involved in movement disorders associated with the basal ganglia through selectively modulating glutamate in the striatum.[63]
Inducing experimental autoimmune encephalomyelitis in animals as a model for multiple sclerosis(MS) has targeted some glutamate receptors as a pathway for potential therapeutic applications.[62] This research has found that a group of drugs interact with the NMDA, AMPA, and kainate glutamate receptor to control neurovascular permeability, inflammatory mediator synthesis, and resident glial cell functions including CNS myelination. Oligodendrocytes in the CNS myelinate axons; the myelination dysfunction in MS is partly due to the excitotoxicity of those cells. By regulating the drugs which interact with those glutamate receptors, regulating glutamate binding may be possible, and thereby reduce the levels of Ca2+ influx. The experiments showed improved oligodendrocyte survival, and remyelination increased. Furthermore, CNS inflammation, apoptosis, and axonal damage were reduced.[62]
During ischemia, the brain has been observed to have an unnaturally high concentration of extracellular glutamate.[60] This is linked to an inadequate supply of ATP, which drives the glutamate transport levels that keep the concentrations of glutamate in balance.[61] This usually leads to an excessive activation of glutamate receptors, which may lead to neuronal injury. After this overexposure, the postsynaptic terminals tend to keep glutamate around for long periods of time, which results in a difficulty in depolarization.[61] Antagonists for NMDA and AMPA receptors seem to have a large benefit, with more aid the sooner it is administered after onset of the neural ischemia.[37]
In addition to similar mechanisms causing Parkinson's disease with respect to NMDA or AMPA receptors, Huntington's disease was also proposed to exhibit metabolic and mitochondrial deficiency, which exposes striatal neurons to the over activation of NMDA receptors.[37] Using folic acid has been proposed as a possible treatment for Huntington's due to the inhibition it exhibits on homocysteine, which increases vulnerability of nerve cells to glutamate.[59] This could decrease the effect glutamate has on glutamate receptors and reduce cell response to a safer level, not reaching excitotoxicity.
In 2004, a specific genotype of human GluR6 was discovered to have a slight influence on the age of onset of Huntington's disease.[58]
Research is being done to address the possibility of using hyperglycemia and insulin to regulate these receptors and restore cognitive functions. Pancreatic islets regulating insulin and glucagon levels also express glutamate receptors.[27] Treating diabetes via glutamate receptor antagonists is possible, but not much research has been done. The difficulty of modifying peripheral GluR without having detrimental effects on the central nervous system, which is saturated with GluR, may be the cause of this.
Diabetes mellitus, an endocrine disorder, induces cognitive impairment and defects of long-term potential in the hippocampus, interfering with synaptic plasticity. Defects of long-term potential in the hippocampus are due to abnormal glutamate receptors, to be specific the malfunctioning NMDA glutamate receptors during early stages of the disease.[57]
Diabetes is a peculiar case because it is influenced by glutamate receptors present outside of the central nervous system, and it also influences glutamate receptors in the central nervous system.
A link between glutamate receptors and autism was also identified via the structural protein ProSAP1 SHANK2 and potentially ProSAP2 SHANK3. The study authors concluded that the study "illustrates the significant role glutamatergic systems play in autism" and "By comparing the data on ProSAP1/Shank2−/− mutants with ProSAP2/Shank3αβ−/− mice, we show that different abnormalities in synaptic glutamate receptor expression can cause alterations in social interactions and communication. Accordingly, we propose that appropriate therapies for autism spectrum disorders are to be carefully matched to the underlying synaptopathic phenotype."[48]
The etiology of autism may include excessive glutamatergic mechanisms. In small studies, memantine has been shown to significantly improve language function and social behavior in children with autism.[54][55] Research is underway on the effects of memantine in adults with autism spectrum disorders.[56]
A SciBX article in January 2012 commented that "UPenn and MIT teams have independently converged on mGluRs as players in ADHD and autism. The findings suggest agonizing mGluRs in patients with ADHD".[53]
Further mutations to four different metabotropic glutamate receptor genes were identified in a study of 1013 children with ADHD compared to 4105 controls with non-ADHD, replicated in a subsequent study of 2500 more patients. Deletions and duplications affected GRM1, GRM5, GRM7 and GRM8. The study concluded that "CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10−9)", "over 200 genes interacting with glutamate receptors [. .] were collectively affected by CNVs", "major hubs of the (affected genes') network include TNIK50, GNAQ51, and CALM", and "the fact that children with ADHD are more likely to have alterations in these genes reinforces previous evidence that the GRM pathway is important in ADHD".[47]
In 2006 the glutamate receptor subunit gene GRIN2B (responsible for key functions in memory and learning) was associated with ADHD.[50] This followed earlier studies showing a link between glutamate modulation and hyperactivity (2001),[51][51] and then between the SLC1A3 solute carrier gene-encoding part of the glutamate transporter process that mapped to a chromosome (5p12) noted in multiple ADHD genome scans.[52]
Hyperalgesia is directly involved with spinal NMDA receptors. Administered NMDA antagonists in a clinical setting produce significant side effects, although more research is being done in intrathecal administration.[37] Since spinal NMDA receptors link the area of pain to the brain's pain processing center, the thalamus, these glutamate receptors are a prime target for treatment. One proposed way to cope with the pain is subconsciously through the visualization technique.[49]
In most cases these are areas of ongoing research.
Glutamate receptors have been found to have an influence in ischemia/stroke, seizures, Parkinson's disease, Huntington's disease, and aching,[45] addiction[46] and an association with both ADHD[47] and autism.[48]
Excessive synaptic receptor stimulation by glutamate is directly related to a many conditions. Magnesium is one of many antagonists at the glutamate receptor, and magnesium deficiencies have demonstrated relationships with many glutamate receptor-related conditions.[44]
A number of diseases in humans have a proven association with genetic mutations of glutamate receptor genes, or autoantigen/antibody interactions with glutamate receptors or their genes. Glutamate receptors and impaired regulation (in particular, those resulting in excessive glutamate levels) are also one cause of excitotoxicity (described above), which itself has been implicated or associated with a number of specific neurodegenerative conditions where neural cell death or degradation within the brain occurs over time.[39][43]
Glutamate receptors' significance in excitotoxicity also links it to many neurogenerative diseases. Conditions such as exposure to excitotoxins, old age, congenital predisposition, and brain trauma can trigger glutamate receptor activation and ensuing excitotoxic neurodegeneration. This damage to the central nervous system propagates symptoms associated with a number of diseases.[43]
In the case of traumatic brain injury or cerebral ischemia (e.g., cerebral infarction or hemorrhage), acute neurodegeneration caused by excitotoxicity may spread to proximal neurons through two processes. Hypoxia and hypoglycemia trigger bioenergetic failure; mitochondria stop producing ATP energy. Na+/K+-ATPase can no longer maintain sodium/potassium ion concentration gradients across the plasma membrane. Glutamate transporters (EAATs), which use the Na+/K+ gradient, reverse glutamate transport (efflux) in affected neurons and astrocytes, and depolarization increases downstream synaptic release of glutamate.[41] In addition, cell death via lysis or apoptosis releases cytoplasmic glutamate outside of the ruptured cell.[42] These two forms of glutamate release cause a continual domino effect of excitotoxic cell death and further increased extracellular glutamate concentrations.
Glutamate excitotoxicity triggered by overstimulation of glutamate receptors also contributes to intracellular oxidative stress. Proximal glial cells use a cystine/glutamate antiporter (xCT) to transport cystine into the cell and glutamate out. Excessive extracellular glutamate concentrations reverse xCT, so glial cells no longer have enough cystine to synthesize glutathione (GSH), an antioxidant.[38] Lack of GSH leads to more reactive oxygen species (ROSs) that damage and kill the glial cell, which then cannot reuptake and process extracellular glutamate.[39] This is another positive feedback in glutamate excitotoxicity. In addition, increased Ca2+ concentrations activate nitric oxide synthase (NOS) and the over-synthesis of nitric oxide (NO). High NO concentration damages mitochondria, leading to more energy depletion, and adds oxidative stress to the neuron as NO is a ROS.[40]
High Ca2+ concentrations activate a cascade of cell degradation processes involving proteases, lipases, nitric oxide synthase, and a number of enzymes that damage cell structures often to the point of cell death.[36] Ingestion of or exposure to excitotoxins that act on glutamate receptors can induce excitotoxicity and cause toxic effects on the central nervous system.[37] This becomes a problem for cells, as it feeds into a cycle of positive feedback cell death.
Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through a process called excitotoxicity. Excessive glutamate, or excitotoxins acting on the same glutamate receptors, overactivate glutamate receptors (specifically NMDARs), causing high levels of calcium ions (Ca2+) to influx into the postsynaptic cell.[35]
Various neurological disorders are accompanied by antibody or autoantigen activity associated with glutamate receptors or their subunit genes (e.g. GluR3 in Rasmussen's encephalitis,[31] and GluR2 in nonfamilial olivopontocerebellar degeneration.[32] In 1994 GluR3 was shown to act as an autoantigen in Rasmussen's encephalitis, leading to speculation that autoimmune activity might underlie the condition.[33] Such findings "suggest" links between glutamate receptors and autoimmune interactions are possible and may be significant in some degenerative diseases,[32] however the exact role of such antibodies in disease manifestation is still not entirely known.[34]
Specific medical conditions and symptoms are discussed below.
Glutamate receptors are thought to be responsible for the reception and transduction of umami taste stimuli. Taste receptors of the T1R family, belonging to the same class of GPCR as metabotropic glutamate receptors are involved. Additionally, the mGluRs, as well as ionotropic glutamate receptors in neural cells, have been found in taste buds and may contribute to the umami taste.[25] Numerous ionotropic glutamate receptor subunits are expressed by heart tissue, but their specific function is still unknown. Western blots and northern blots confirmed the presence of iGluRs in cardiac tissue. Immunohistochemistry localized the iGluRs to cardiac nerve terminals, ganglia, conducting fibers, and some myocardiocytes.[26] Glutamate receptors are (as mentioned above) also expressed in pancreatic islet cells.[27] AMPA iGluRs modulate the secretion of insulin and glucagon in the pancreas, opening the possibility of treatment of diabetes via glutamate receptor antagonists.[28][29] Small unmyelinated sensory nerve terminals in the skin also express NMDA and non-NMDA receptors. Subcutaneous injections of receptor blockers in rats successfully analgesized skin from formalin-induced inflammation, raising possibilities of targeting peripheral glutamate receptors in the skin for pain treatment.[30]
Because of this, mGluRs can both increase or decrease the excitability of the postsynaptic cell, thereby causing a wide range of physiological effects.
[24] Glutamate binding to the extracellular region of an mGluR causes G proteins bound to the intracellular region to be phosphorylated, affecting multiple biochemical pathways and ion channels in the cell.[23] The transmembrane region consists of seven transmembrane domains and connects the extracellular region to the intracellular region where G protein coupling occurs.[22] binding from in the VFT module to the transmembrane region.ligand and a cysteine-rich domain that is thought to play a role in transmitting the conformational change induced by [23],glutamate The extracellular region is composed of a venus flytrap (VFT) module that binds [22]
Gabâ, Iran, Isfahan, Gaba Corporation, Makindye
Learning, Psychology, Consciousness, Thought, Attention
Peripheral nervous system, Spinal cord, Synapse, Central nervous system, Meninges
Memory, Glutamate, Ethanol, Xenon, Learning
Glutamate, Eglumegad, Ibotenic acid, GiG0 alpha subunits, Eglu
Gene, Adar, Public domain, Protein Data Bank, Ensembl
NMDA receptor, Psychology, Psychiatry, Basal ganglia, Obsessive–compulsive disorder
Glutamate, Ethanol, Ibotenic acid, Quisqualic acid, Evans blue


text:
Elderly Caretakers
Correct me if I'm wrong, but weren't the caretakers of the summer home James' Grandparents. I think I remember something about them being related. - Count Caterpie 2:13 11 October 2007 (UTC)
- "Nanny" and "Pop Pop" could take on multiple meanings...--Shiningpikablu252 01:20, 12 October 2007 (UTC)
I just watched the episode and I noticed that in one flashback of James' youth he is seen playing with a Weepinbell. Since the only thing known about his first Victreebel is that it evolved form a Weepinbell, couldn't it be possible it was just that same Weepinbell he was playing with as a kid? Which is something similar of what happened with Carnivine. I'm not saying it has to be the same, but I think it could be mentioned as a trivia.--CiaobyDany (talk) 19:15, 24 January 2014 (UTC)
- I've actually often thought along those same lines. In my personal opinion, it's certainly worth mentioning in Trivia at the very least. - unsigned comment from Missingno. Master (talk • contribs) 12:14, 4 April 2014 (UTC)


text:
There are several saints given prominent veneration at this mission.
High on the wall of the church is an oil painting of Saint Francisco Solano after whom the mission was named. Francisco Solano was born in Spain of noble parents in 1549. He joined the Franciscan order at the age of 20 and was ordained a priest at age 27. He spent his life as a missionary in Peru and Paraguay. He was noted as a preacher and an accomplished musician (he played the violin). Saint Francis Solano is known as the Apostle of South America. He was canonized in 1726.
There is a bulto (carved statue) of San Jose (Saint Joseph) on the right side of the altar in the chapel and a bulto of Our Lady of Sorrows on the left. There is a bas-relief image of San Juan Bautista on the tabernacle.