Parmi les stations commerciales nationales disposant d'une fréquence à Saintes figurent notamment Nostalgie (88.7 FM), Europe 1 (89.4 FM), Fun Radio (92.9 FM), Virgin Radio (93.7 FM), NRJ (94.4 FM), Radio Nova (95.2 FM), RMC (98.1 FM) ou encore RTL (105.9 FM). 