The CLARITY extension study: a two-year Phase III placebo-controlled study, following on from the CLARITY study to evaluate the safety and efficacy of cladribine over four years.
The ORACLE MS (Oral Cladribine in Early MS) study: a two-year Phase III placebo-controlled study to evaluate the efficacy and safety of cladribine as a monotherapy in patients at risk of developing MS because they have experienced a first clinical event suggestive of MS.
The ONWARD (Oral Cladribine Added ON To Interferon beta-1a in Patients With Active Relapsing Disease) study: a Phase II placebo-controlled study to evaluate the safety and tolerability of adding cladribine to interferon-beta therapy in RMS patients who have experienced breakthrough disease while on interferon-beta.
At the Joint ECTRIMS-ACTRIMS Meeting in October 2017, Czech investigators reported that cladribine has an effect on relapses comparable to Gilenya® (fingolimod), and an impact on MS-related disability similar to Gilenya and interferon-beta. They added that cladribine may be associated with superior recovery from disability relative to Gilenya, interferon-beta, and Tysabri® (natalizumab).