Nucyreta Tablet ER is used for moderate to severe pain.
Nucyreta 50mg Tablet ER decreases the perception of pain by blocking the transmission of pain signals to the brain.
The full name of your medicine is ‘NUCYRETA ER Tablets, 50mg extended release tablets’.
Tapentadol – the active substance in NUCYRETA– is a strong painkiller which belongs to the class of opioids. NUCYRETA is used in adults for the treatment of moderate to severe pain of recent onset that can only be adequately managed with an opioid painkiller.
• have a tendency to abuse medicines or if you are dependent on medicines, as NUCYRETA may lead to addiction. In this case, you should only take these tablets for short periods of time and under strict medical supervision.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Your doctor will tell you which medicines are safe to take with NUCYRETA ER 50.
• Your breathing may become dangerously slow or shallow (respiratory depression) if you are taking certain sleeping pills or tranquilizers (e.g. barbiturates, benzodiazepines), or pain relievers such as morphine and codeine (also as cough medicine) in combination with NUCYRETA ER 50.
If this happens tell your doctor.
• Your consciousness may be decreased, you may feel drowsier or feel you might faint, if you take NUCYRETAwith sedatives (such as benzodiazepines), antipsychotics (medicines that affect the state of mind or emotions), H1-antihistamines, opioids or alcohol. If this happens tell your doctor.
• If you are taking a type of medicine that affects serotonin levels (e.g. certain medicines to treat depression), speak to your doctor before taking NUCYRETA as there have been cases of “serotonin syndrome”.
Serotonin syndrome is a rare, but life-threatening condition. The signs include confusion, restlessness, fever, sweating, uncoordinated movement of arms, legs or eyes, uncontrollable jerking of muscles, muscle twitches and diarrhoea. Your doctor can advise you on this.
• NUCYRETA may not work as well if taken with opioid like medicines (e.g. those containing pentazocine, nalbuphine or buprenorphine).
Tell your doctor if you are currently being treated with one of these medicines.
Wort) that affects the enzymes required to remove NUCYRETA from the body, may affect how well NUCYRETA works or may cause side effects. The effects may occur especially when the other medication is started or stopped.
• NUCYRETAshould not be taken together with monoamine oxidase inhibitors (MAOIs – certain medicines for the treatment of depression).
Tell your doctor if you are taking or have taken MAO inhibitors during the last 14 days.
Please keep your doctor informed about all medicines you are taking.
Do not drink alcohol whilst you are taking NUCYRETA ER 50, because some side effects such as drowsiness may be increased. You can take NUCYRETA with or without food.
• if you become pregnant during treatment with NUCYRETA ER 50. Check with your doctor.
• if you are breast-feeding, as it may pass into the breast milk.
If you feel drowsy, dizzy, have blurred vision or a slow reaction time whilst taking NUCYRETA ER 50, then do not drive, use tools or machinery.
Any such effects are more likely to occur when you start taking NUCYRETA ER 50, when the dose of NUCYRETAis changed, or when you drink alcohol or take tranquilizers.
Please ask your doctor before driving a car or using machinery.
Your doctor will change the dose and time between doses of NUCYRETA according to your pain level and your needs. Generally, the lowest pain relieving dose should be taken.
Daily doses greater than 700 mg tapentadol on the first day of treatment and daily doses greater than 600 mg tapentadol on the following days of treatment are not recommended.
Your doctor may prescribe a different, more appropriate dose or timing of dosing, if this is necessary for you. If you feel that the effect of these tablets is too strong or weak, talk to your doctor or pharmacist.
Swallow the tablets with a glass of water. You may take the tablets either on an empty stomach or with food.
Do not take the tablets for longer than your doctor has told you.
In elderly patients (above 65 years) usually no dose adjustment is necessary. However, your doctor may adjust your dose or time between doses if required.
Do not take NUCYRETA if you have severe liver or kidney problems.
If you have moderate liver problems, your doctor will adjust your dose or time between doses.
If you have mild liver problems or mild to moderate kidney problems, a dose adjustment is not required.
NUCYRETA is not recommended for children and adolescents below the age of 18 years.
Taking too much NUCYRETA may be life-threatening.
If you forget to take the tablets, your pain is likely to return. Do not take a double dose to make up for a forgotten dose; simply continue taking the tablets as before.
If you interrupt or stop treatment too soon, your pain is likely to return.
If you wish to stop treatment, please tell your doctor first before stopping treatment.
Generally there will be no withdrawal effects when treatment is stopped.
However, on uncommon occasions, people who have been taking the tablets for some time may feel unwell if they suddenly stop taking them.
• increase in blood pressure, breathing or heart rate.
If you experience any of these complaints after stopping NUCYRETA ER 50, please contact your doctor.
Do not stop taking this medicine unless your doctor tells you to. If your doctor wants you to stop taking your tablets, he/she will tell you how to do this. This may include a gradual reduction of the dose.
• This medicine may cause allergic reactions including swelling beneath the skin, hives, and in severe cases difficulty breathing, a fall in blood pressure, collapse, or shock (rare). Symptoms may be wheeziness, difficulty breathing, swelling of the eyelids, face or lips, or rash or itching, which may cover your whole body.
• Another serious side effect is a condition where you breathe more slowly or weakly than expected (uncommon). It mostly occurs in elderly and weak patients.
If you are affected by these important side effects contact a doctor immediately.
• muscle cramps, feeling of weakness, tiredness or exhaustion (fatigue), feeling of body temperature change.
• feeling strange, drunk, irritable or relaxed.
• delayed emptying of the stomach (impaired gastric emptying).
In general, the likelihood of having suicidal thoughts and behaviour is increased in patients suffering from chronic pain. In addition, certain medicines for the treatment of depression (which have an impact on the neurotransmitter system in the brain) may increase this risk, especially at the beginning of treatment. Although tapentadol also affects neurotransmitters, data from human use of tapentadol do not provide evidence for an increased risk.
Ask your pharmacist how to throw away medicines you no longer use.
The active ingredient is tapentadol.
One (1) tablet contains 50 mg tapentadol (as hydrochloride).
One (1) tablet contains 100 mg tapentadol (as hydrochloride).
One (1) tablet contains 150 mg tapentadol (as hydrochloride).
One (1) tablet contains 200 mg tapentadol (as hydrochloride).
• Tablet core: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.
• Tablet coat: polyvinylalcohol, titanium dioxide (E 171), macrogol 3350, talc.
NUCYRETA tablets are white round shaped film-coated tablets, marked on both the sides.
NUCYRETA tablets are packed in blisters.