Two simple spectrophotometric methods have been developed for simultaneous estimation of meclizine hydrochloride and caffeine from tablet dosage form. Method I is an absorbance correction method in which absorbance is measured at two wavelengths, 288 nm at which meclizine hydrochloride has no absorbance and 236 nm at which both the drugs have considerable absorbance. Method II is simultaneous equation method which involves two wavelengths, 236 nm (for measurement of meclizine hydrochloride) and 273 nm (for measurement of caffeine). Both the methods were found linear between the range of 4-20 µg/ml for caffeine and 5-25 µg/ml for meclizine hydrochloride. The accuracy and precision were determined and found to comply with ICH guidelines. Both the methods showed good reproducibility and recovery with % RSD in the desired range. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of meclizine hydrochloride and caffeine in their combined tablet dosage form.
Meclizine hydrochloride, Caffeine, Absorbance correction method, Simultaneous equation method.