Russ Poldrack is back! For our eleventh episode, we sat down with Dr. Poldrack to discuss his book, The New Mind Readers: What Neuroimaging Can and Cannot Reveal about Our Thoughts. Our conversation addresses a number of the most pressing questions in psychology and neuroscience today. Why can we de-code some cognitive functions in the brain, but not others? How might we use neuroimaging to guide personalized medicine? What can we do to ensure our science is conducted in the most reproducible and rigorous ways? And is it really necessary to study the brain in order to understand human behavior?