Tahamtan, M., Shamsizadeh, A., Allahtavakoli, M., Nami, M., Mohammadi, N., Hassanshahi, G. (2017). Differential Expression of CXCL1, CXCL10, and CXCL12 in Response to Cerebral Ischemic Postconditioning in Rat Brain. Journal of Advanced Medical Sciences and Applied Technologies, 3(4), 197-204.
Mahshid Tahamtan; Ali Shamsizadeh; Mohammad Allahtavakoli; Mohammad Nami; Neda Mohammadi; Gholamhossein Hassanshahi. "Differential Expression of CXCL1, CXCL10, and CXCL12 in Response to Cerebral Ischemic Postconditioning in Rat Brain". Journal of Advanced Medical Sciences and Applied Technologies, 3, 4, 2017, 197-204.
Tahamtan, M., Shamsizadeh, A., Allahtavakoli, M., Nami, M., Mohammadi, N., Hassanshahi, G. (2017). 'Differential Expression of CXCL1, CXCL10, and CXCL12 in Response to Cerebral Ischemic Postconditioning in Rat Brain', Journal of Advanced Medical Sciences and Applied Technologies, 3(4), pp. 197-204.
Tahamtan, M., Shamsizadeh, A., Allahtavakoli, M., Nami, M., Mohammadi, N., Hassanshahi, G. Differential Expression of CXCL1, CXCL10, and CXCL12 in Response to Cerebral Ischemic Postconditioning in Rat Brain. Journal of Advanced Medical Sciences and Applied Technologies, 2017; 3(4): 197-204.
1Physiology Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Objectives: Cerebral ischemic preconditioning lessens stroke-induced injuries, but it is clinically feasible only when the occurrence of stroke is predictable. Reperfusion plays a critical role against cerebral injury after stroke; we tested the hypothesis that interrupting ischemia during early reperfusion, i.e. Postconditioning (POCO) affects CXC chemokine expression and further reduce inflammation in rat model of ischemia/reperfusion. Materials & Methods: Adult male Wistar rats (250-300 g) were used in this experiment. Using 4-vessel occlusion method, global cerebral ischemia was induced and POCO was performed by applying 3 cycles of 15-s/15-s reperfusion/reocclusion after a 45-s reperfusion (POCO-45-15/15). Western blotting analysis was used to investigate CXCL1, CXCL10 and CXCL12 expression 24 h, 48 h and one week after ischemic postconditioning (iPOCO).Results: Based on the results, iPOCO attenuates the expression of inflammatory chemokines CXCL1 and CXCL10 in hippocampus area of postconditioned rats, while the CXCL12 was not affected by iPOCO.Conclusion: Current findings may support chemokines role in iPOCO via reduction of inflammation. Also there could be a link between postconditioning, stress and inflammation through chemokines.
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