Dylan Larkin and Andreas Athanasiou scored two goals each for the Red Wings, who rallied from a 4-1 third-period deficit to tie it.
However, Erik Gustafsson found Kane alone to the right of the net in overtime, and the Chicago star beat goalie Jonathan Bernier for his 38th goal of the season.
CALGARY, Alberta (AP) — Austin Czarnik and Johnny Gaudreau scored 29 seconds apart in the third period to lead Calgary.
Mikael Backlund and Travis Hamonic also scored as Calgary won its third straight after a four-game skid. Mike Smith stopped 17 shots.
Casey Cizikas and Anders Lee scored for the Islanders, who had tied it earlier in the third after trailing 2-0 following one period. Thomas Greiss finished with 28 saves in New York's third regulation loss in 16 games.
LAS VEGAS (AP) — David Backes scored in the sixth round of a shootout to lift Bostontp its season-high seventh straight victory.
Jake DeBrusk and Brad Marchand scored in regulation as the Bruins improved to 8-1-1 in the last 10 on the road — including wins in the first four games of a western trip. The win streak is their longest since a 12-game run in 2014. Jaroslav Halak stopped 31 shots.
The Bruins, who are 9-0-3 in their last 12 overall, haven't lost in regulation since a 3-2 setback to the New York Rangers on Jan. 19.
Reilly Smith and Nate Schmidt scored for Vegas, while Marc-Andre Fleury finished with 25 saves. Fleury has lost four in a row and seven of his last nine starts. He has allowed 19 goals in last five starts, and 28 in the nine-game span.
DENVER (AP) — Nathan MacKinnon and Matt Calvert scored 11 seconds apart in the third period, Semyon Varlamov made 26 saves in another strong performance and Colorado won two in a row for the first time since late November.
Carl Soderberg, Mikko Rantanen, Tyson Jost, Gabriel Landeskog and A.J. Greer also scored for the Avalanche. In addition, MacKinnon's power-play goal snapped an 0-for-29 dry spell on the man advantage.
The only score Varlamov allowed was to Kyle Connor with Colorado staked to a 4-0 lead.