The three mammalian Aurora kinases (A, B and C) play essential roles cell division, by regulating mitosis and the cell cycle. These are evolutionarily conserved serine/threonine protein kinases, sharing a high degree of sequence homology, but with quite different subcellular distributions and functions [4,6,10]. Aurora kinases A and B are widely expressed in dividing cells, whereas Aurora kinase C expression appears to be restricted to the testes [9,15]. Their importance in the mitotic cycle has driven the development of Aurora kinase inhibitors as therapeutic antimitotic agents for both adult and childhood malignancies.
Aurora kinase (Aur) family. Accessed on 25/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=557.