Papademetriou, M. and RICHARDS, J. and Correia, T. and Blasi, Anna and Murphy, D.G.M. and Lloyd-Fox, Sarah and Elwell, Clare and Johnson, Mark H. (2013) Cortical mapping of 3D optical topography in infants. In: Van Huffel, S. and Naulaers, G. and Caicedo, A. and Bruley, D.F. and Harrison, D.K. (eds.) Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology 789. New York, U.S.: Springer, pp. 455-461. ISBN 9781461474111.
Precise localisation of cortical activation in the early development of the infant brain remains unclear. It is challenging to co-register haemodynamic responses during functional activation in infants with the underlying anatomy of the brain. We used a multispectral imaging algorithm to reconstruct 3D optical topographic images of haemodynamic responses in an infant during voice processing. In this chapter, we present a method for co-registering 3D optical topography images reconstructed from functional activation data in infants onto anatomical brain images obtained from MRI structurals of the individual infants.