Does increased dietary calcium or calcium supplementation (CaS) affect risk for fracture in participants > 50 years of age?
Included studies assessed dietary sources of calcium (milk, dairy products, dietary calcium intake from food, or hydroxyapatite) or CaS, alone or combined with other treatment (e.g., vitamin D), as long as the other treatment was given to both groups, in participants > 50 years of age. Exclusion criteria were major systemic pathology (e.g., renal failure or caancer). Primary outcome was fractures.
Published: Ann Intern Med. 2016;164(2):JC4.
Extracellular mild acidosis decreases the Ca2+ permeability of the human NMDA receptors.