My project aims to improve counseling of Lynch syndrome patients by assessing the impact of mismatch repair gene mutations in the context of the human non-diseased or patient genome. I am using human iPS cells where mutations are introduced through oligonucleotide-directed gene modification or oligonucleotide-templated site-specific-nuclease-induced DSB repair.
I obtained my BSc and MSc degrees in Life Science and Technology in Leiden and Delft before starting my PhD in the Te Riele group in 2011.