Ribeiro CV, Rocha BFB, Moreira DS, Peruhype-Magalhães V, Murta SMF. Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony. Parasit Vectors. 2019 Jan 25; 12(1):60. PMID: 30683152.
Fonseca MS, Comini MA, Resende BV, Santi AM, Zoboli AP, Moreira DS, Murta SM. Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony. Exp Parasitol. 2017 Apr; 175:36-43. PMID: 28167207.
Moreira DS, Murta SM. Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype. Parasit Vectors. 2016 12 13; 9(1):641. PMID: 27964761.
Elias PR, Coelho GS, Xavier VF, Sales Junior PA, Romanha AJ, Murta SM, Carneiro CM, Camilo NS, Hilário FF, Taylor JG. Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity. Molecules. 2016 Oct 10; 21(10). PMID: 27735872.
Dos Santos PF, Moreira DS, Baba EH, Volpe CMO, Ruiz JC, Romanha AJ, Murta SMF. Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Exp Parasitol. 2016 Nov; 170:1-9. PMID: 27567984.
Andrade JM, Baba EH, Machado-de-Avila RA, Chavez-Olortegui C, Demicheli CP, Frézard F, Monte-Neto RL, Murta SM. Silver and Nitrate Oppositely Modulate Antimony Susceptibility through Aquaglyceroporin 1 in Leishmania (Viannia) Species. Antimicrob Agents Chemother. 2016 08; 60(8):4482-9. PMID: 27161624.
de Souza Moreira D, Ferreira RF, Murta SM. Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines. Exp Parasitol. 2016 Jan; 160:60-6. PMID: 26689884.
Gonçalves VN, Cantrell CL, Wedge DE, Ferreira MC, Soares MA, Jacob MR, Oliveira FS, Galante D, Rodrigues F, Alves TM, Zani CL, Junior PA, Murta S, Romanha AJ, Barbosa EC, Kroon EG, Oliveira JG, Gomez-Silva B, Galetovic A, Rosa CA, Rosa LH. Fungi associated with rocks of the Atacama Desert: taxonomy, distribution, diversity, ecology and bioprospection for bioactive compounds. Environ Microbiol. 2016 Jan; 18(1):232-45. PMID: 26235221.
Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC. Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain. Eur J Med Chem. 2015 Aug 28; 101:818-35. PMID: 26231082.
Moreira Dde S, Pescher P, Laurent C, Lenormand P, Späth GF, Murta SM. Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology. Proteomics. 2015 Sep; 15(17):2999-3019. PMID: 25959087.
Lavorato SN, Sales Júnior PA, Murta SM, Romanha AJ, Alves RJ. In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures. Mem Inst Oswaldo Cruz. 2015 Jun; 110(4):566-8. PMID: 26061148.
de Carvalho CR, Vieira Mde L, Cantrell CL, Wedge DE, Alves TM, Zani CL, Pimenta RS, Sales Junior PA, Murta SM, Romanha AJ, Rosa CA, Rosa LH. Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus. Nat Prod Res. 2016; 30(4):478-81. PMID: 25812930.
Godinho VM, Gonçalves VN, Santiago IF, Figueredo HM, Vitoreli GA, Schaefer CE, Barbosa EC, Oliveira JG, Alves TM, Zani CL, Junior PA, Murta SM, Romanha AJ, Kroon EG, Cantrell CL, Wedge DE, Duke SO, Ali A, Rosa CA, Rosa LH. Diversity and bioprospection of fungal community present in oligotrophic soil of continental Antarctica. Extremophiles. 2015 May; 19(3):585-96. PMID: 25809294.
Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. PMID: 25712353.
Batista FA, Almeida GS, Seraphim TV, Silva KP, Murta SM, Barbosa LR, Borges JC. Identification of two p23 co-chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities. FEBS J. 2015 Jan; 282(2):388-406. PMID: 25369258.
Rêgo JV, Duarte AP, Liarte DB, de Carvalho Sousa F, Barreto HM, Bua J, Romanha AJ, Rádis-Baptista G, Murta SM. Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Exp Parasitol. 2015 Jan; 148:73-80. PMID: 25450774.
Tessarollo NG, Andrade JM, Moreira DS, Murta SM. Functional analysis of iron superoxide dismutase-A in wild-type and antimony-resistant Leishmania braziliensis and Leishmania infantum lines. Parasitol Int. 2015 Apr; 64(2):125-9. PMID: 25449290.
Stoco PH, Wagner G, Talavera-Lopez C, Gerber A, Zaha A, Thompson CE, Bartholomeu DC, Lückemeyer DD, Bahia D, Loreto E, Prestes EB, Lima FM, Rodrigues-Luiz G, Vallejo GA, Filho JF, Schenkman S, Monteiro KM, Tyler KM, de Almeida LG, Ortiz MF, Chiurillo MA, de Moraes MH, Cunha Ode L, Mendonça-Neto R, Silva R, Teixeira SM, Murta SM, Sincero TC, Mendes TA, Urmenyi TP, Silva VG, DaRocha WD, Andersson B, Romanha AJ, Steindel M, de Vasconcelos AT, Grisard EC. Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli. PLoS Negl Trop Dis. 2014 Sep; 8(9):e3176. PMID: 25233456.
Andrade JM, Murta SM. Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasit Vectors. 2014 Aug 29; 7:406. PMID: 25174795.
Moreira DS, Monte Neto RL, Andrade JM, Santi AM, Reis PG, Frézard F, Murta SM. Molecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony. Int J Parasitol Drugs Drug Resist. 2013 Dec; 3:143-53. PMID: 24533304.
Matrangolo FS, Liarte DB, Andrade LC, de Melo MF, Andrade JM, Ferreira RF, Santiago AS, Pirovani CP, Silva-Pereira RA, Murta SM. Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines. Mol Biochem Parasitol. 2013 Aug; 190(2):63-75. PMID: 23831370.
Seraphim TV, Alves MM, Silva IM, Gomes FE, Silva KP, Murta SM, Barbosa LR, Borges JC. Low resolution structural studies indicate that the activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis has an elongated shape which allows its interaction with both N- and M-domains of Hsp90. PLoS One. 2013; 8(6):e66822. PMID: 23826147.
dos Santos PF, Ruiz JC, Soares RP, Moreira DS, Rezende AM, Folador EL, Oliveira G, Romanha AJ, Murta SM. Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi. Parasit Vectors. 2012 Aug 07; 5:161. PMID: 22871258.
Soares RP, Torrecilhas AC, Assis RR, Rocha MN, Moura e Castro FA, Freitas GF, Murta SM, Santos SL, Marques AF, Almeida IC, Romanha AJ. Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of a-galactosyl residues. Am J Trop Med Hyg. 2012 Jul; 87(1):87-96. PMID: 22764297.
Nogueira FB, Rodrigues JF, Correa MM, Ruiz JC, Romanha AJ, Murta SM. The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide. Mem Inst Oswaldo Cruz. 2012 Jun; 107(4):494-502. PMID: 22666860.
Lye LF, Owens K, Shi H, Murta SM, Vieira AC, Turco SJ, Tschudi C, Ullu E, Beverley SM. Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS Pathog. 2010 Oct 28; 6(10):e1001161. PMID: 21060810.
Jannotti-Passos LK, Ruiz JC, Caldeira RL, Murta SM, Coelho PM, Carvalho OS. Phylogenetic analysis of Biomphalaria tenagophila (Orbigny, 1835) (Mollusca: Gastropoda). Mem Inst Oswaldo Cruz. 2010 Jul; 105(4):504-11. PMID: 20721500.
Liarte DB, Murta SM. Selection and phenotype characterization of potassium antimony tartrate-resistant populations of four New World Leishmania species. Parasitol Res. 2010 Jun; 107(1):205-12. PMID: 20372925.
Aguirre KL, Alves JB, Silva GA, Cardoso JE, Murta SM, Ferreira AJ. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 2009 Aug; 104(5):715-9. PMID: 19820831.
Quaresma PF, Murta SM, Ferreira Ede C, da Rocha-Lima AC, Xavier AA, Gontijo CM. Molecular diagnosis of canine visceral leishmaniasis: identification of Leishmania species by PCR-RFLP and quantification of parasite DNA by real-time PCR. Acta Trop. 2009 Sep; 111(3):289-94. PMID: 19467216.
Madeira da Silva L, Owens KL, Murta SM, Beverley SM. Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7583-8. PMID: 19383793.
Vickers TJ, Murta SM, Mandell MA, Beverley SM. The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major. Mol Biochem Parasitol. 2009 Aug; 166(2):142-52. PMID: 19450731.
Campos FM, Liarte DB, Mortara RA, Romanha AJ, Murta SM. Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi. Acta Trop. 2009 Jul; 111(1):56-63. PMID: 19426664.
Murta SM, Vickers TJ, Scott DA, Beverley SM. Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major. Mol Microbiol. 2009 Mar; 71(6):1386-401. PMID: 19183277.
Liarte DB, Murta SM, Steindel M, Romanha AJ. Trypanosoma cruzi: multiplex PCR to detect and classify strains according to groups I and II. Exp Parasitol. 2009 Dec; 123(4):283-91. PMID: 19133262.
Nogueira FB, Ruiz JC, Robello C, Romanha AJ, Murta SM. Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Parasitol Res. 2009 Mar; 104(4):835-44. PMID: 19018566.
Andrade HM, Murta SM, Chapeaurouge A, Perales J, Nirdé P, Romanha AJ. Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole. J Proteome Res. 2008 Jun; 7(6):2357-67. PMID: 18435557.
Murta SM, Nogueira FB, Dos Santos PF, Campos FM, Volpe C, Liarte DB, Nirdé P, Probst CM, Krieger MA, Goldenberg S, Romanha AJ. Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Acta Trop. 2008 Jul; 107(1):59-65. PMID: 18501872.
Jannotti-Passos LK, Andrade HM, Caldeira RL, Romanha AJ, Murta SM, Chapeaurouge DA, Perales J, Coelho PM, Carvalho OS. Proteome analysis of the cardiac and pericardial tissue of Biomphalaria tenagophila populations susceptible and resistant to Schistosoma mansoni infection. Acta Trop. 2008 Mar; 105(3):229-34. PMID: 18262165.
Steindel M, Kramer Pacheco L, Scholl D, Soares M, de Moraes MH, Eger I, Kosmann C, Sincero TC, Stoco PH, Murta SM, de Carvalho-Pinto CJ, Grisard EC. Characterization of Trypanosoma cruzi isolated from humans, vectors, and animal reservoirs following an outbreak of acute human Chagas disease in Santa Catarina State, Brazil. Diagn Microbiol Infect Dis. 2008 Jan; 60(1):25-32. PMID: 17889480.
Rego JV, Murta SM, Nirdé P, Nogueira FB, de Andrade HM, Romanha AJ. Trypanosoma cruzi: characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations. Exp Parasitol. 2008 Jan; 118(1):111-7. PMID: 17678649.
Nogueira FB, Krieger MA, Nirdé P, Goldenberg S, Romanha AJ, Murta SM. Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole. Acta Trop. 2006 Nov; 100(1-2):119-32. PMID: 17113553.
Murta SM, Krieger MA, Montenegro LR, Campos FF, Probst CM, Avila AR, Muto NH, de Oliveira RC, Nunes LR, Nirdé P, Bruna-Romero O, Goldenberg S, Romanha AJ. Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi. Mol Biochem Parasitol. 2006 Apr; 146(2):151-62. PMID: 16442642.
Veloso VM, Romanha AJ, Lana M, Murta SM, Carneiro CM, Alves CF, Borges EC, Tafuri WL, Machado-Coelho GL, Chiari E, Bahia MT. Influence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite. Parasitol Res. 2005 Aug; 96(6):382-9. PMID: 15940522.
Anacleto C, Abdo MC, Ferreira AV, Murta SM, Romanha AJ, Fernandes AP, Moreira ES. Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line. Parasitol Res. 2003 Jun; 90(2):110-8. PMID: 12756544.
Romanha AJ, Alves RO, Murta SM, Silva JS, Ropert C, Gazzinelli RT. Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure. J Infect Dis. 2002 Sep 15; 186(6):823-8. PMID: 12198617.
Machado EM, Fernandes AJ, Murta SM, Vitor RW, Camilo DJ, Pinheiro SW, Lopes ER, Adad SJ, Romanha AJ, Pinto Dias JC. A study of experimental reinfection by Trypanosoma cruzi in dogs. Am J Trop Med Hyg. 2001 Dec; 65(6):958-65. PMID: 11792006.
Murta SM, dos Santos WG, Anacleto C, Nirdé P, Moreira ES, Romanha AJ. Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes. Mol Biochem Parasitol. 2001 Oct; 117(2):223-8. PMID: 11606233.
Djikeng A, Ferreira L, D'Angelo M, Dolezal P, Lamb T, Murta S, Triggs V, Ulbert S, Villarino A, Renzi S, Ullu E, Tschudi C. Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Mol Biochem Parasitol. 2001 Mar; 113(1):109-15. PMID: 11254959.
Talvani A, Ribeiro CS, Aliberti JC, Michailowsky V, Santos PV, Murta SM, Romanha AJ, Almeida IC, Farber J, Lannes-Vieira J, Silva JS, Gazzinelli RT. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect. 2000 Jul; 2(8):851-66. PMID: 10962268.
Murta SM, Ropert C, Alves RO, Gazzinelli RT, Romanha AJ. In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population. Parasite Immunol. 1999 Oct; 21(10):535-44. PMID: 10610497.
Murta SM, Romanha AJ. Characterization of Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:177-80. PMID: 10677710.
Michailowsky V, Murta SM, Carvalho-Oliveira L, Pereira ME, Ferreira LR, Brener Z, Romanha AJ, Gazzinelli RT. Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi. Antimicrob Agents Chemother. 1998 Oct; 42(10):2549-56. PMID: 9756754.
Murta SM, Gazzinelli RT, Brener Z, Romanha AJ. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol Biochem Parasitol. 1998 Jun 01; 93(2):203-14. PMID: 9662705.
Murta SM, Romanha AJ. In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole. Parasitology. 1998 Feb; 116 ( Pt 2):165-71. PMID: 9509026.
Zani CL, Chiari E, Krettli AU, Murta SM, Cunningham ML, Fairlamb AH, Romanha AJ. Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones. Bioorg Med Chem. 1997 Dec; 5(12):2185-92. PMID: 9459016.
Fernandes CD, Murta SM, Cerávolo IP, Krug LP, Vidigal PG, Steindel M, Nardi N, Romanha AJ. Characterization of Trypanosoma cruzi strains isolated from chronic chagasic patients, triatomines and opossums naturally infected from the State of Rio Grande do Sul, Brazil. Mem Inst Oswaldo Cruz. 1997 May-Jun; 92(3):343-51. PMID: 9332599.
Steindel M, Toma HK, Ishida MM, Murta SM, de Carvalho Pinto CJ, Grisard EC, Schlemper BR, Ribeiro-Rodrigues R, Romanha AJ. Biological and isoenzymatic characterization of Trypanosoma cruzi strains isolated from sylvatic reservoirs and vectors from the state of Santa Catarina, Southern Brazil. Acta Trop. 1995 Dec; 60(3):167-77. PMID: 8907395.
Alves TM, Chaves PP, Santos LM, Nagem TJ, Murta SM, Ceravolo IP, Romanha AJ, Zani CL. A diterpene from Mikania obtusata active on Trypanosoma cruzi. Planta Med. 1995 Feb; 61(1):85-7. PMID: 7701002.
Steindel M, Dias Neto E, Pinto CJ, Grisard EC, Menezes CL, Murta SM, Simpson AJ, Romanha AJ. Randomly amplified polymorphic DNA (RAPD) and isoenzyme analysis of Trypanosoma rangeli strains. J Eukaryot Microbiol. 1994 May-Jun; 41(3):261-7. PMID: 8049688.