Ingelheim, Germany March 8, 2016 – Boehringer Ingelheim today announced the presentation of new post-hoc analyses that show the addition of SPIRIVA® (tiotropium) Respimat® to other asthma maintenance therapies helps improve lung function and asthma symptom control, while reducing asthma exacerbations (also known as flare-ups), independent of a patient’s subtype of allergic asthma.1,2,3 These data were presented at the 2016 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting in Los Angeles.
These analyses evaluated the safety and efficacy of adding SPIRIVA® Respimat® to other maintenance therapies compared to placebo across the broad range of asthma patients studied, regardless of the allergic (Immunoglobulin E or IgE) and inflammatory (eosinophilic) levels.
People living with allergic asthma – the most common form of the condition – experience inflammation and a tightening of the airways due to exposure to common allergens. These patients may need other inhaled options that complement their existing therapy.
The PrimoTinA-asthma® trials investigated SPIRIVA® Respimat® as an add-on therapy for adults with asthma who continued to have symptoms despite taking at least ICS/LABA therapy.
The MezzoTinA-asthma® trials investigated SPIRIVA® Respimat® as an add-on therapy for adults with asthma who continued to have symptoms despite taking at least moderate-dose ICS therapy.
Asthma is not solved. Almost 1 in 2 patients remain symptomatic despite their current maintenance therapies (usually ICS/LABA). These symptoms have a detrimental effect on their work, sleep, social life and intimate relationships. Additionally, symptoms increase their risk of potentially fatal asthma flare-ups in the next few weeks by up to six times.
1 Casale, Thomas B. et al. Tiotropium Respimat® Add-on to at Least Ics Therapy Demonstrates Reduced Risk of Severe Asthma Exacerbation and Asthma Worsening in Symptomatic Asthma, Independent of IgE or Blood Eosinophil Levels. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB214.
2 Vandewalker, Mark L. et al. Once-Daily Tiotropium Respimat® Add-on to at Least Ics Maintenance Therapy Demonstrates Improved Asthma Control in Patients with Symptomatic Asthma, Independent of Serum IgE or Blood Eosinophil Levels. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB210.
3 Tashkin, Donald P. et al. Once-Daily Tiotropium Respimat® Add-on to at Least Ics Maintenance Therapy Demonstrates Improved Lung Function in Patients with Symptomatic Asthma, Independent of Serum IgE or Blood Eosinophil Levels. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB213.
4 Boehringer Ingelheim. Data on file.
5 electronic Medicines Compendium (eMC) http://www. medicines.org.uk/emc/medicine/2317/SPC/Seretide.
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7 SPIRIVA® Respimat® SPC 09/2014.
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