The FTSE 100 was stuck in the red following the High Court’s decision that Parliament must vote on whether the UK government can trigger Article 50 and start the process of leaving the EU.
The FTSE 250 climbed 0.7% to 17,581 as sterling rallied over 1% against both the US dollar and euro in response to the news.
Inflation is expected to reach 2.7% next year, up from 1%, according to the Bank of England. Economic growth forecasts have been raised from 0.8% to 1.4% for next year.
West Texas Intermediate (WTI) crude oil slumped 1.5% to $44.64 and Brent crude oil fell 1.2% to $46.28 per barrel, respectively.
Gold cheapened 0.6% to $1,298 per ounce and copper rose 0.7% to $4,938 per tonne.
Non-farm business sector labour productivity rose by 3.1% annual rate during the third quarter of 2016, according to the US Bureau of Labor Statistics.
Supermarket Morrisons (MRW) made fresh gains on its fourth consecutive quarter of growth, which was helped by its biggest ever Halloween.
Randgold Resources (RRS) disappointed investors as its latest results failed to meet expectations, although the company did show some signs of recovery after a difficult second quarter.
Satellites operator Inmarsat (ISAT) was among the biggest risers as the stock jumped 10.3% to 805.5p on impressive third quarter results. The group reported an increase in revenue following strong performances in the government and aviation divisions, but a drop in pre-tax profit.
Shares in insurer Esure (ESUR) plummeted 26% to 196p, as the market priced in the demerger of its Gocompare.com (GOCO) business, which was spun-out into a separate quoted company.
Sugar maker Tate & Lyle (TATE) sweetened 3.8% as adjusted full-year pre-tax profit is expected to be higher than anticipated due to a strong first-half performance.
Retail bank Shawbrook (SHAW) reported new loans increased by 23% to £1.5bn in the third quarter.
Kitchen supplier Howden Joinery (HWDN) slumped 5.7% despite its total revenue rising by 4.1% in the second half to 29 October in tougher conditions and softer trading.
Engineering recruitment agency Gattaca (GATC) reported a slowdown in trading in the UK with group NFI in the first quarter of 2017 forecast to be 3% lower compared to the first quarter of 2016. Shares fell 14.5% to 292p.
Shares in digital distribution services provider Zoo Digital (ZOO) soared 12.5% on strong interim results, which revealed pre-tax profit more than doubled from $0.3m to $0.7m.
Sirius Minerals (SXX) raised £370m through a firm placing in connection with its stage one financing requirements to begin construction of its North Yorkshire polyhalite project.
Gold miner Xtract Resources (XTR) hit the skids after securing expensive-looking new funding arrangements, including a new shares subscription and an equity swap deal.
Energy firm Plutus Powergen (PPG) was in demand after securing its first UK power generation site in the UK. The deal sparked an 8% rally in the share price to 1.62p.