Macrogol 3350 is a clinically proven treatment for constipation that is well tolerated in both adults and children. 1,2,3 Overall macrogol laxatives are more effective than lactulose in adults and are generally better tolerated.1 Most studies are of short duration, but evidence includes trials that have evaluated the use of macrogol laxatives for up to 12 months.
The use of macrogol laxatives in adults is considered a first step after bulking-forming agents (e.g. psyllium).
Macrogol laxatives are considered first line in children if simple lifestyle measures don't help.
1. Katelaris P, Naganathan V, Liu K, Krassas G, Gullotta J. Comparison of the effectiveness of polyethylene glycol with and without electrolytes in constipation: a systematic review and network meta-analysis. BMC Gastroenterol 2016; 16:42.
2. Krassas G, Gullotta J, Katelaris P, Naganathan V, Liu K, Cranswick N. Polyethylene glycols with or without electrolytes for constipation. in children: A network meta-analysis . GP16 Abstract 67. 2016.
3. Pare P, Fedorak RN. Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation. Can J Gastroenterol Hepatol 2014; 28(10):549-557.
4. Alper A, Pashankar DS. Polyethylene glycol: a game-changer laxative for children. J Pediatr Gastroenterol Nutr 2013; 57(2):134-140.