The bacteria, Porphyromonas gingivalis, known as Pg, causes the gum infection chronic periodontitis, causing chronic inflammation and potential loss of teeth, reported CNN.
According to Zlokovic and his researchers, as the brain and its vessels deteriorate, toxic proteins and other harmful molecules make their way into active brain tissue, damaging areas of the brain that are essential for memory. They also discovered bacterial enzymes called gingipains that destroy brain cells were present, too.
However, there was also good news. They found toxins called gingipains produced by P. gingivalis in 96% of the samples and the bacterium itself in three samples. They also demonstrate the presence of P. gingivalis DNA in post-mortem Alzheimer's brain samples (both hippocampus and cerebral cortex) and in the CSF of living patients who are believed to have the disease as well.
Previous studies have established a link between periodontal disease and Alzheimer's, Lynch said.
"We know for sure that the blood brain barrier is contributing to the evolution of each of those diseases in different ways".
The researchers hope a drug that inhibits the spread of P. gingivalis in the brain could slow the symptoms of the neurodegenerative disorder. COR388 showed positive trends across several cognitive tests in patients suffering from AD, and Cortexyme plans to initiate a Phase 2 and 3 clinical trial of COR388 in mild to moderate AD in 2019.
The Washington post published a report about the study by researchers at the University of Louisville (USA), during which they had identified bacteria that can cause Alzheimer's disease. They used a compound that targeted the gingipains, which likely supply nutrients to the bacteria, to successfully kill off the bacteria, reducing neurodegeneration and the formation of beta-amyloid protein.
Laboratory tests indicated that gingipain enzymes may trigger tau tangles - knots of proteins within neurons that are thought to drive the damage caused by Alzheimer's.
The bacteria also increased production of amyloid beta, a component of the amyloid plaques commonly associated with Alzheimer's.
Antibiotics also worked similarly well, but less effectively.
The Alzheimer's Association says they are supporting multiple bills this session that will help the cause. "I'm much less convinced that [it] causes Alzheimer's disease", says neurobiologist Robert Moir of the Harvard University-affiliated Massachusetts General Hospital (MGH) in Boston, whose work suggests the β-amyloid protein that forms plaques in the brains of Alzheimer's patients is a protective response to microbial invaders.
BDA scientific adviser Professor Damien Walmsley said: "This study offers a welcome reminder that oral health can't remain an optional extra in our health service".
To explore whether the bacteria were causing disease, the team swabbed the gums of healthy mice with P. gingivalis every other day for 6 weeks to establish an infection. "Findings support the critical need for additional research with minority groups".
The family of a 3-year-old boy from North Carolina claimed that he was protected by a bear while missing for three days. The US Marine Corps also joined the search effort, Hughes said. "I want to thank all of the volunteers that came out".
The 2019 All-Star Game will take place at Spectrum Center in Charlotte, North Carolina, on February 17. The starters were determined by a combination of votes from fans, media and players .
Still, the trades are interesting because they signal Cincinnati is basically all-in for a longshot attempt at contending in 2019. That will leave many of Cincinnati's young pitchers to battle for the final rotation spot and provide depth in case of injury.
Residents are seen in an area next to a dam owned by Brazilian miner Vale SA that burst, in Brumadinho, Brazil January 25, 2019. The town is best known to tourists for Inhotim, an outdoor contemporary art museum, which was evacuated as a precaution.
Trump criticised the Democratic leader of the House Nancy Pelosi for withdrawing a previous invitation to deliver the address. Secret Service, questioning whether they could secure the speech given that they have been operating without funding.
It also makes these older devices a bargain, offering Samsung Galaxy Watch features at a more affordable price. Fortunately, the new update lets Gear S3 and Gear Sport users change the music directly via the smartwatch.
I think we had areas where were we did well and others in which they were better". The performance was good but they took advantage of all their chances'.
US Commerce Secretary Wilbur Ross said Monday that China's economy was more vulnerable to the fallout from the trade war. Trump wants to reduce the massive trade deficit with China. "I think there will be deal".