Take advantage of the larger brain size of the rat coupled with its richer behavioral profile. Unlike BAC models, our rats express cre recombinase off of the endogenous promoters, so you don’t have to worry about ectopic expression or random integration and potential gene disruption.
Our tdTomato reporter rat possesses the fluorophore tdTomato, sitting behind a floxed stop codon in the Rosa26 locus. Simply introduce Cre- recombinase through viral transduction or by crossing with one of our Cre- driver rats, and observe tdTomato fluorescence anywhere Cre- is expressed.
Horizon has generated two opsin lines to help you simplify your optogenetics experiments by eliminating the need for viral transduction. Possessing either Channelrhodopsin (excitatory) or Halorhodopsin (inhibitory) behind a floxed stop codon, simply breed with our Cre- driver rats to get neuronal subtype-specific expression of your opsin of choice.