Today we are discussing the epidemic rise of autoimmune disease, what this means for the autoimmune patient, and significant associations between autoimmune disease and the gastrointestinal tract. The information regarding this association is increasing at a fast rate and today we will be discussing some of this information.
1. Role of MAIT cells in the immunopathogenesis of inflammatory diseases: New players in old game.
2. Severe intestinal dysbiosis is prevalent in primary Sjögren’s syndrome and is associated with systemic disease activity.
Mandl T, Marsal J, Olsson P, Ohlsson B, Andréasson K.
Arthritis Res Ther. 2017 Oct 24;19(1):237. doi: 10.1186/s13075-017-1446-2.
3. Nature, nurture, and microbes: The development of multiple sclerosis.
Acta Neurol Scand. 2017 Nov;136 Suppl 201:22-25. doi: 10.1111/ane.12843. Review.
4. Mesenchymal stromal cells modulate gut inflammation in experimental colitis.
de Aguiar CF, Castoldi A, Andrade-Oliveira V, Ignacio A, da Cunha FF, Felizardo RJF, Bassi ÊJ, Câmara NOS, de Almeida DC.
5. Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation.
Wang X, Ni L, Chang D, Lu H, Jiang Y, Kim BS, Wang A, Liu X, Zhong B, Yang X, Dong C.
EBioMedicine. 2017 Nov;25:165-174. doi: 10.1016/j.ebiom.2017.10.010. Epub 2017 Oct 12.
6. The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists.
Lerner A, Neidhöfer S, Matthias T.
Microorganisms. 2017 Oct 12;5(4). pii: E66. doi: 10.3390/microorganisms5040066. Review.
7. Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.
Rouxel O, Da Silva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.
Nat Immunol. 2017 Dec;18(12):1321-1331. doi: 10.1038/ni.3854. Epub 2017 Oct 9.
8. Context-specific effects of genetic variants associated with autoimmune disease.
Hum Mol Genet. 2017 Oct 1;26(R2):R185-R192. doi: 10.1093/hmg/ddx254.
9. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37.
Conti P, Caraffa A, Ronconi G, Kritas SK, Mastrangelo F, Tettamanti L, Theoharides TC.
Eur J Pharmacol. 2017 Sep 29;818:294-299. doi: 10.1016/j.ejphar.2017.09.044. [Epub ahead of print] Review.
10. Gut Microbiota, Immune System, and Bone.
Calcif Tissue Int. 2017 Sep 30. doi: 10.1007/s00223-017-0331-y. [Epub ahead of print] Review.
11. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression.
Wang Y, Mumm JB, Herbst R, Kolbeck R, Wang Y.
J Immunol. 2017 Nov 1;199(9):3316-3325. doi: 10.4049/jimmunol.1700152. Epub 2017 Sep 22.
12. Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine.
Nakamura YK, Janowitz C, Metea C, Asquith M, Karstens L, Rosenbaum JT, Lin P.
Sci Rep. 2017 Sep 18;7(1):11745. doi: 10.1038/s41598-017-12163-3.
13. Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation.
Sheng L, Jena PK, Hu Y, Liu HX, Nagar N, Kalanetra KM, French SW, French SW, Mills DA, Wan YY.
J Pathol. 2017 Dec;243(4):431-441. doi: 10.1002/path.4983. Epub 2017 Nov 1.
14. The silent enemy: Celiac disease goes viral.
Reale A, Trevisan M, Alvisi G, Palù G.