Purpose To investigate the association between selfreported exposure to disturbing noise and risk of long-term sickness absence (LTSA) for more than two consecutive weeks among office workers. Methods LTSA was measured using register data that were linked to survey data from 2,883 office workers aged 18–59 who were surveyed in 2005 on exposure to disturbing noise. The risk of LTSA was investigated using Cox proportional hazards model. Results Of the study population, 4.4 % had LTSA in the 1-year follow-up period. Compared to office workers who were ‘rarely or never’ exposed to disturbing noise at work, office workers who reported being ‘frequently’ exposed to disturbing noise had a significantly increased estimated risk of LTSA when adjusting for age, gender, smoking status, and managerial position (HR = 1.90; 95 % CI, 1.12–3.22). After additional adjustment for psychosocial work conditions, the estimated risk of LTSA for office workers who were frequently exposed to disturbing noise became marginally insignificant (HR = 1.73; 95 % CI, 0.99–3.01). A subgroup analysis showed that women who reported being frequently exposed to disturbing noise had a significantly increased estimated risk of LTSA (HR = 1.94; 95 % CI, 1.04–3.64), whereas the corresponding risk for men was insignificant (HR = 1.28; 95 % CI, 0.37–4.41). Conclusions This study indicates that frequent selfreported exposure to disturbing noise at work is associated with increased risk of LTSA among office workers and that this association may be stronger for women than for men.