Sitagliptin (Januvia®) is unlikely to interact with most other medications. In fact, there is only one known drug interaction with sitagliptin. Taking sitagliptin and digoxin (Digitek®, Lanoxin®) together can slightly increase the level of digoxin in your blood. As a result. your healthcare provider should monitor your digoxin levels when starting or stopping sitagliptin.
It is possible that not all drug interactions with sitagliptin are known at this time. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.