My lab studies the cytoskeleton, particularly how motile cells use actin polymerization to propel themselves forward. This process is responsible for correct development of multicellular organisms; for wound healing; for proper function of the immune system; and for remodeling and regeneration in the nervous system. Loss of regulation of this process contributes to invasion and metastasis of cancerous cells. We ask: (1) What structures drive cell movement and how do cells construct them? (2) How do molecular assemblies generate the force required to deform cell membranes? (3) How does intracellular signaling control the assembly and function of these macromolecular machines?