Ovaj enzim je protohemoprotein. Kod sisara, enzim je lociran u jetri.
↑ Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iizuka, T., Ishimura, Y., Nozawa, T. and Hatano, M. (1983). "Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms". J. Biol. Chem. 258: 2519–2525. PMID 6600455.
↑ Ren, S., Liu, H., Licad, E. and Correia, M.A. (1996). "Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme". Arch. Biochem. Biophys. 333: 96–102. PMID 8806758.
↑ Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K. and Wiseman, J.S. (1993). "Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase". J. Biol. Chem. 268: 17781–17786. PMID 8349662.
↑ Dang, Y., Dale, W.E. and Brown, O.R. (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway". Free Radic. Biol. Med. 28: 615–624. PMID 10719243.
↑ Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). "Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase". J. Biol. Chem. 278: 29525–29531. PMID 12766158.
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