General Description: An electroresponsive drug delivery system that incorporates non-toxic, biodegradable FDA approved nanomaterials. Applying weak electric stimuli (0.5-1.5 V, 50-400 uA) to the nanocomposites can control the timing and quantity of drug release. This system demonstrated relatively high drug loading (>30%) and can release of both small molecules (molecular weight <500 amu) and macromolecules (molecular weights >3000 amu), hydrophilc as well as hydrophobic compounds. The conductive composition and the method of electric field-induced compound release is essential for programmed drug delivery.
Samanta, Devleena, Rohan Mehrotra, Katy Margulis, and Richard N. Zare. "On-demand electrically controlled drug release from resorbable nanocomposite films." Nanoscale 9, no. 42 (2017): 16429-16436.