After shutting down Opera then reopen same day no reboot or next day after computer reboot Opera has lost it setting.
Why Opera not saving setting?
Here Opera keeps its settings. Check if there isn't anything avoiding Opera to save them or even reverting them back.
CCleaner might be the culprit. Are you using its latest version?
Check if there isn't anything avoiding Opera - Hard to see any software bugging Opera.
Just unstalled CCleaner Have now reinstall, I hope this has fixed.
Just got to reboot computer finger crossed.