These controls are used to activate or deactivate options. Use LMB to change their state. A tick is shown on checkboxes when the option is activated. Active status on toggle buttons is indicated either by color on the icon background, or a change in icon graphics.
To change many values at once on or off, you can press down LMB and drag over multiple buttons. This works for check boxes, toggles and to select a radio button value.
Radio buttons are used to choose one option from a selection of options. Active button is indicated by color on the icon background.
Use Ctrl-Wheel, while hovering with the mouse over radio buttons, to cycle between the options.