Biotinylated Human CD84, His Tag, Avi Tag (CD4-H82E5) is expressed from human 293 cells (HEK293). It contains AA Lys 22 - Gly 225 (Accession # Q9UIB8-3).
The protein has a calculated MW of 26.5 kDa. The protein migrates as 40-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Biotinylated Human CD84, His Tag, Avi Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.
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(2) Tangye S.G., et al., 2002, Eur. J. Immunol. 32:1640-1649.
(3) Zaiss M., et al., 2003, Exp. Hematol. 31:798-805.