“The EPA FIFRA Scientific Advisory Panel will meet on December 2-5, 2014 to consider and review scientific issues related to “Integrated Bioactivity and Exposure Ranking: A Computational Approach for the Prioritization and Screening of Chemicals in the Endocrine Disruptor Screening Program.” The meeting will be held at the Environmental Protection Agency, Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA 22202.
3. The scientific support for the potential substitution of these HTS assays for some of the lower throughput assays that are currently part of EDSP screening.
This paper also describes new science for an integrated bioactivity and exposure ranking (IBER) approach to rank chemicals and prioritize further EDSP consideration. The IBER approach is demonstrated using estrogen and androgen receptor pathway, with mention of parallel efforts underway to develop similar models for the androgen receptor pathway.
All meeting materials (e.g., charge questions, background document, agenda, and all other EPA materials) are available in the e-docket, EPA-HQ-OPP-2014-0614 (http://www.regulations.gov).
This meeting will be accessible thru a live online webcast. The live webcast will enable interested persons to listen to the entire public meeting and to view the PowerPoint presentations displayed at the meeting. To participate in the live webcast, please click on the link below to access the webcast instructions. The webcast link will not be active until 15 minutes prior to the start of the meeting. You must use a PC and Internet Explorer as your browser. Link to Instructions: http://www.epa.gov/scipoly/sap/webcast.pdf. Please note that the webcast is a supplementary public process provided only for convenience. If difficulties arise resulting in webcasting outages, the meeting will continue as planned.