實際研究例如 Kimko, H. C., Reele, S. S., Holford, N. H., & Peck, C. C. (2000). Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model. Clinical Pharmacology & Therapeutics, 68(5), 568-577.