This report presents a cost analysis of large-scale Methanol production from natural gas. The process examined employs combined reforming for syngas generation similarly to the technologies developed by the following companies: Lurgi, Toyo, KBR, Johnson Matthey/Davy and Haldor-Topsoe. In this process, natural gas is converted into syngas in two steps: steam reforming and autothermal reforming. In the steam reformer, the natural gas reacts with steam and, in the secondary (autothermal) reformer, it reacts with oxygen. The syngas generated is then converted to Methanol. This study provides readers with key and hard-to-find information regarding a production process technology and its economics, such as a description of the manufacturing process and industrial site installations, plant construction cost breakdown, production cost breakdown, and raw materials consumption figures.