The rapid pace of evolution in domino/cascade-based transformations has revolutionized the practice of chemical synthesis for the creation of natural products, designed molecules, and pharmaceuticals. Highlighting the current state of the art by teaching the skills and providing the tools needed for success, these two volumes, written by 60 experts, aim to communicate the power, artistry, and challenge of domino chemistry, while also demarcating frontiers for future developments.
The volumes are organized by the core type of reaction used to initiate the domino event; Volume 1 covers polyene/cation-π cyclizations, the synthesis of polyether natural products by polyepoxide ring-opening, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.
Volume 2 focuses on pericyclic reactions, for example, Diels–Alder, sigmatropic shifts, and ene reactions. Alkylative dearomatization reactions, additions to non-activated alkenes (e.g., halocyclizations), activated alkenes (e.g., Michael reactions, enamine/enol ether reactions), and to C=O and C=N bonds are also covered in this volume.
Together they provide an effective way to compare and contrast approaches in domino chemistry. Using representative examples along with experimental procedures for processes with high generality, key lessons can be imparted effectively for developing even more powerful domino approaches.