Normal serum urate levels are usually achieved in 1 to 3 weeksThe upper limit of normal is about 7 mg/dL for men and postmenopausal women and 6 mg/dL for premenopausal womenToo much reliance should not be placed on a single serum uric acid determination sincefor technical reasonsestimation of uric acid may be difficultBy selecting the appropriate dosage andin certain patientsusing uricosuric agents concurrentlyit is possible to reduce serum uric acid to normal orif desiredto as low as 2 to 3 mg/dL and keep it there indefinitely.
Bone marrow depression has been reported in patients receiving Zyloprimmost of whom received concomitant drugs with the potential for causing this reactionThis has occurred as early as 6 weeks to as long as 6 years after the initiation of therapy of ZyloprimRarelya patient may develop varying degrees of bone marrow depressionaffecting one or more cell lineswhile receiving Zyloprim alone.
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