If you're looking for a new job, it's tempting to stay behind a computer, scouring job boards and other sites. In reality, the best thing for your career might be to get out and get around town, or better yet, nearby towns as well. You may find companies nearby with openings that you can research and apply for.
I actually used to do this a lot when I hated my old job, but it's good advice for anyone looking to make a good career move. Hop in the car, or get on the subway or bus, and ride around to the business parks or parts of town you don't often explore (but are accessible to you.) Start in nearby locations that are easy commutes, or places you'd love to work. Look around at the tops of those buildings, or on the front (or better yet, in Google while you're there) to find out what businesses are located there. Take some notes.
Then, expand your search out a bit. Maybe visit the next town over, or head out further on your closest train line. Do the same thing, and do a little exploring. Getting out of the house and out from behind a computer screen will do your mind some good, and with luck you'll come back with tons of candidate companies you can look up, read all about, and best of all, check for available openings you can apply to. Then it's all about getting in touch with the right people, sending in your resume, and waiting for the call.
Glassdoor mentions this tip in passing in the post below, which is packed with other suggestions if your tried and true job search tips have failed so far. Check it out.
Used to do this myself. Always worked. Pick up local papers, see something in their job ads that probably didn't make it to the jobnetwork providers or whatever was around before Seek in those days.
Next town over, only takes a few days to know if there's anything there. Took a couple weeks to go to The City.