Strain adaptation in the early life human microbiome – DalMUG – Dalhousie Microbiome User Group (DalMUG).
Vatanen et al., 2019. Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life, Nature Microbiology.
Tommi Vatanen and colleagues describe a well-sampled cohort of children from the DIABIMMUNE study that consists of 289 children who carry HLA haplotypes that confer an increased risk of autoimmune disorders. The researchers collected a longitudinal set of over 3000 stool samples through following the subjects from birth for three years from children in Finland, Estonia, and Russian Karelia.
In this publication, the authors focus on microbial strain diversity through two methods: single nucleotide polymorphism (SNP) tracking (using StrainPhlAn), and assembly-based strain tracking. Due to the longitudinal nature of the study, they were able to track genetic changes in microbes within an infant over time. Microbes that had the greatest genetic diversity included Haemophilus parainfluenzae and Faecalibacterium prausnitzii.
Through CRISPR array reconstruction, they also suggest that bacteriophages may be contributing to the observed genomic changes in Bacteroides spp., although more in-depth work is needed to confirm this mechanism.
We were satisfied overall with this publication that describes a cohort that will better delineate the link between early human gut microbiome development and host immunity.