Japanese Encephalitis (JE) is a viral disease that infects humans and animals. JE causes inflammation of the membranes around the brain. It is transmitted to humans through bites from infected mosquitoes. This disease is mainly in rural and partially urban settings, with transmission often increasing during the rainy seasons, when large epidemics can occur. Signs and symptoms of JE are typically mild and include fever and headache. More severe symptoms of JE include rapid onset of high fever, headache, neck stiffness, disorientation, coma, seizures, spastic paralysis, and death. Those who survive may suffer permanent intellectual, behavioral, or neurological problems, such as paralysis, recurrent seizures, or the inability to speak. There is currently no cure for JE, but safe and effective vaccines are available to prevent JE.