Summary of cholesterol management recommendations from the AHA ADA cardiovascular disease (CVD) prevention in type 2 diabetes guidelines.
Exploring DPP-4 CV safety in SAVOR-TIMI 53 and EXAMINE, CV outcomes in Look AHEAD, relationship between gastric bypass and A1C and cardiometabolic risk factors, metabolic effects of bariatric surgery and medical therapy in STAMPEDE, statin use and diabetes risk, severe hypoglycemia and CVD disease risk.
Ikramuddin S, Korner J, Lee W-J, et al. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia. JAMA. 2013;309(21):2240-2249.
Rautio N, Jokelainen J, Oksa H, et al. Do statins interfere with lifestyle intervention in the prevention of diabetes in primary healthcare? One-year follow-up of the FIN-D2D project. BMJ Open. 2012;2(5). pii: e001472. doi: 10.1136/bmjopen-2012-001472. Treatment with statins has been linked to an increased risk for type 2 diabetes in several post-hoc evaluations of previous completed trials, leading to controversy regarding the risk/benefit profile of statin therapy for primary prevention in patients who are at low risk for developing cardiovascular (CV) events.
Peter Libby, MD, on New JUPITER Analysis: "These Data Put Diabetes Risk from Statin Therapy in Perspective" NDEI.org expert commentary explores statins and diabetes risk September 18, 2012: NDEI.org, the official website of The National Diabetes Education Initiative® (NDEI®) published expert commentary from Peter Libby, MD, on a new analysis of the landmark JUPITER primary prevention trial demonstrating that the cardiovascular and mortality benefits conferred by statin therapy outweigh the risk for developing diabetes among patients at low risk for cardiovascular disease (CVD).
Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308(6):581-590. Carnethon and colleagues analyzed data from five clinical trials to compare mortality rates among subjects who were normal weight with subjects who were overweight/obese at the time of incident adult-onset diabetes.