Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on this kinase. BCK1 probably phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
"A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint."
Harrison J.C., Bardes E.S.G., Ohya Y., Lew D.J.
"A yeast MAPK cascade regulates pexophagy but not other autophagy pathways."
Manjithaya R., Jain S., Farre J.C., Subramani S.
"Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog."
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF THR-1119; ILE-1120; GLY-1146 AND ALA-1174.
"MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C."
Irie K., Takase M., Lee K.S., Levin D.E., Araki H., Matsumoto K., Oshima Y.
"Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae."
Chen Y., Feldman D.E., Deng C., Brown J.A., De Giacomo A.F., Gaw A.F., Shi G., Le Q.T., Brown J.M., Koong A.C.
"A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth."
Costigan C., Gehrung S., Snyder M.
"SLK1, a yeast homolog of MAP kinase activators, has a RAS/cAMP-independent role in nutrient sensing."
"The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae."
Claret S., Gatti X., Doignon F., Thoraval D., Crouzet M.
"Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast."
Narayanaswamy R., Moradi E.K., Niu W., Hart G.T., Davis M., McGary K.L., Ellington A.D., Marcotte E.M.
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407; SER-411; SER-491; SER-816; SER-1058 AND SER-1061, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747 AND SER-1058, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
M84389 Genomic DNA No translation available.
M88604 Genomic DNA Translation: AAA21179.1 Sequence problems.