Professor Murphy is an international leader in the field of cartilage biology with his focus on hypoxia and microRNA function in human cartilage. More recently he has developed genome editing approaches to investigate these issues.
His standing at the forefront of cartilage biology research is further evidenced by many speaker invitations at the premier research conferences in the world in his field (including Gordon Research Conferences and OARSI).
Within the UK, he was awarded the 2010 Michael Mason Prize - a most prestigious award bestowed by the British Society for Rheumatology, and selected by the esteemed Heberden Committee 'for excellence in clinical or scientific research in the field of Rheumatology'. Prof Murphy also presented his work at the opening plenary session of the society's Rheumatology 2010 conference attended by over 2,000 delegates.
Prof Murphy has served on the Experts research committee of the UK research council - Biotechnology and Biological Sciences Research Council (BBSRC) whose remit is to assess responsive mode funding applications.
He has also served on the committee of the British Society for Matrix Biology which promotes matrix biology research and organises an annual conference attended by top UK-based and international researchers. He currently serves on the Arthritis Research UK project funding committee.
Prof Murphy also serves as Director of Graduate Studies for the Kennedy Institute and chairs the Institute's Graduate Studies Committee..
miR-1247 functions by targeting cartilage transcription factor SOX9.
Hypoxia promotes the production and inhibits the destruction of human articular cartilage.
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).
The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13.
Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype.
CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.
Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype.
Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes.