Epifanio de los Santos was appointed director of the Philippine National Museum in 1925.
de los Santos was considered one of the best Filipino writers in Spanish of his time. As a young man, he was the first Filipino to become a member of the Spanish Royal Academy of Language, Spanish Royal Academy of Literature and Spanish Royal Academy of History in Madrid and was touted as the "First Filipino Academician".
de los Santos was an associate editor of the revolutionary paper "La Independencia", writing under the pen name G. Solon. He also co-founded other newspapers like La Libertad, El Renaciemento, La Democracia, La Patria and Malaysia.
He was a man of many talents and has been described as a rare genius with his encyclopedic knowledge and talents.
De los Santos built one of the best and rare collections and libraries in the Philippines on Philippine literature, arts, music, politics and biographical and historical sketches of great and notable Filipinos.
Epifanio de los Santos Avenue (commonly known as EDSA), the main road through Metro Manila, was named in honour of him.