‘Monseur Beodoes’ has not been identified. The reference may be to the poet and physician Thomas Lovell Beddoes, whose father, the physician Thomas Beddoes, had been a close friend of the Wedgwood and Darwin families (B. Wedgwood and Wedgwood 1980). ‘Beddoes’ was, however, a fairly common name in early-nineteenth-century Shropshire.
CD refers to two or more of his sisters, Marianne, Caroline Sarah, Susan Elizabeth, and Emily Catherine Darwin, and to his father, Robert Waring Darwin.
The form of the signature is unexplained. CD had previously attended a school run by George Augustus Case in Shrewsbury (Autobiography, p. 22 and n. 1).
CD possibly refers to William Bayley, of the banking firm Rocke, Eyton, Campbell, Leighton and Bayley in Market Square, Shrewsbury, who had been instructed to act in a financial transaction on Robert Waring Darwin’s behalf in January 1820 (DAR 227.6: 339 and 340, Commercial directory for Shropshire). CD’s sister Emily Catherine wrote in her letter of 15 January  that a Major Bayley desired ‘most particularly’ to be remembered to CD (Correspondence vol. 1).
"Monseur Beodoes" is inquisitive and impertinent; Mr Bayly "was formerly a devlish boor". Asks who his sisters have been talking about.