In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close of business on 4 October 2018, being the last business day prior to the date of this announcement, it had 922,079,745 ordinary shares of 5 pence each in issue and admitted to trading on the main market of the London Stock Exchange. Shire holds 7,357,283 ordinary shares in treasury. Accordingly, the total number of voting rights in Shire is 914,722,462. The International Securities Identification Number (“ISIN”) for Shire’s ordinary shares is JE00B2QKY057.