Mayfair and 13 other residential and minor roads will be repaired in October.
A badly-worn and potholed road in Tilehurst is to close for up to two weeks for repairs and resurfacing.
Mayfair will be shut from its junctions at Halls Road and Park Lane from Monday, October 15, while works are carried out.
The road is regularly cited as one of the worst potholed roads in Reading by readers of getreading.
Drivers have had to contend with cracks, potholes and an uneven road surface as a result of the road dressing lifting from the concrete layer underneath.
In March this year, Reading Borough Council revealed the road would be fixed with £66,975 left over from its successful bid for the government's Pothole Action Fund.
Road crews will be in 13 other locations over the next two weeks to resurface residential and minor roads. Temporary road restrictions will be in place while the work is carried out.
Work starts on Thursday, October 4 and should be finished by Sunday, October 7, weather permitting, on the roads in Southcote, Whitley, Emmer Green and Coley.
The work on the minor roads follows the resurfacing of 12 sections of main road over the summer.
Cllr Tony Page, lead councillor for strategic environment, planning and transport, said: “Main roads obviously bear the brunt of the volume of traffic using roads in Reading, but there is also a need to repair residential streets showing the worst damage.
“Local residential streets and minor roads will be the next to benefit from the Council’s annual resurfacing programme.