Me, Myself & I stars Bobby Moynihan in a comedy about the defining moments in one man's life over three distinct periods – as a 14-year-old in 1991, at age 40 in present day, and at age 65 in 2042. As a 14-year-old boy living in Chicago in 1991, Alex was on top of the world, inventing cool things and celebrating the Bulls' first championship, until his mom, Maggie, moved them to Los Angeles, the heart of Lakers country, and married a pilot, Ron. With his new stepbrother, Justin, Alex needed to reinvent himself in a new school, where he meets his dream girl, Nori Sterling. In 2017, 40-year-old Alex is an inventor/entrepreneur on top of the world until his wife leaves him and threatens to take their daughter, Abby, with her, sending him into a tailspin that requires the help of his best friend and business partner, Darryl, to get him back on track. In 2042 at 65, Alex is a highly successful businessman who, after suffering a minor heart attack, decides he's ready to reinvent himself once again. Alex announces he's retiring to his adult daughter, Abby, now the general manager of the Chicago Bulls, and he gets a surprise chance to reconnect with his childhood crush, Nori, who now goes by Eleanor. During these three pivotal periods, Alex always manages to find a way to move forward, handling key moments with determination, emotion, and humor.