Product Overview: This product was highly purified from Clostridium perfringens, strain NCTC8239. The molecular weight is 35 kD. The cytotoxic activity was examined by using Vero cells. The surviving fraction of the cells exposed to 1 ug/ml of CPE for 30 min was less than 40%.
Description: Clostridium perfringens enterotoxin (CPE) is a protein toxin produced by Gram-positive bacteria,C. perfringens. CPE destroys cell membrane structure of animals by its phospholipase activity after binding to the membrane of Claudin family proteins, which are components of tight junction of epithelial cell membrane. CPE binds to Claudins 3, 4, 6, 7, 8 and 14, but not to Claudins 1, 2, 5 and 10.