, 2007). In fact, SK was suggested as spreading factor (Lahteenmaki et al., 2005) and the nephritis streptococci-associated protein (Johnston & Zabriskie, 1986). Palbociclib SK (414 amino acid residues) contains three structural domains (α, β and γ) that exhibit synergistic effects on Plg activation (Kunamneni et al., 2007).
and healthy carriers were identified (Tewodros et al., 1993). Surprisingly, results of this prior study showed an even distribution of the SKN variants among APSGN and non-APSGN isolates, indicating no correlation between sk allelic variations and the disease manifestation (Tewodros et al., 1993). In parallel, studies on strains isolated from aboriginal communities in Australia indicated no association of SKN alleles with APSGN (Haase et al., 1994). Using the same PCR/RFLP method and strains collected from two geographically distinct locations (Ethiopia and Sweden), the lack of correlation between disease manifestation and sk allelic variations for GCS/GGS (besides GAS) was also shown (Tewodros et al., 1996). Results of this preceding study identified other new sk variants (sk10-sk14) that (together with sk5) were proposed as unique alleles belonging to GCS/GGS strains (Tewodros et al., 1996).