See Ioannidis at MSU for video discussion of related topics with the leading researcher in this area, and also Medical Science? Is Science Self-Correcting?
Abstract: Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B)/year spent on preclinical research that is not reproducible—in the United States alone. We outline a framework for solutions and a plan for long-term improvements in reproducibility rates that will help to accelerate the discovery of life-saving therapies and cures.
Authors "raise an eyebrow" at the 300+ factors alleged (cumulatively by many researchers) to contribute to stock returns. Apparently influenced, possibly inspired, by medical reproducibility questions.