Pick up where Serious Sam: Second Encounter left off, Sam has rocketed off towards the conquered planet of Sirius, the new home of the notorious Mental. While en route, the Great Wizards Council of the nearly eradicated Sirian civilization telephatically contacts Sam to aid him in his quest to destroy Mental and help restore sirius.
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Serious Sam 2 has been added to Game-Debate but does not currently have the Serious Sam 2 system requirements.